The nicotinic-induced release of endogenous dopamine from rat striatal slices from animals chronically exposed to dimethylphenylpiperazinium (DMPP).
The effect of the nicotinic agonist, dimethylphenylpiperazinium (DMPP), to release endogenous dopamine (DA) from striatal slices obtained from animals chronically treated with the nicotinic agonist for 7 or 14 days was determined. Endogenous DA was measured by high pressure liquid chromatography coupled to electrochemical detection. There was no difference in the DMPP concentration-effect curve for DA release from slices obtained from untreated rats or rats treated with saline. Treatment with DMPP for 7 days did not change the DMPP concentration-effect curve when compared to saline treatment. In contrast, treatment of rats with DMPP for 14 days resulted in a significant attenuation of the DMPP-induced release of DA. These studies support the hypothesis that chronic treatment with nicotinic agonists results in a functional uncoupling of cholinergic nicotinic receptors facilitating DA release in the striatum.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D010879:Piperazines; D011978:Receptors, Nicotinic; D004246:Dimethylphenylpiperazinium Iodide; D004298:Dopamine