title: [Pharmacological correction of central nervous system function in exposure to Coriolis acceleration].
abstract: Healthy volunteers with a low vestibular tolerance were exposed to Coriolis acceleration. Potassium orotate, pyracetame and riboxine were used as prophylactic measures against disorders in the function of the vestibular apparatus and higher compartments of the higher nervous system. The central nervous function was assessed with respect to the spectral power of electroencephalograms, short-term memory and mental performance. Potassium orotate given at a dose of 40 mg/kg body weight/day during 12-14 days as well as pyracetame given at a dose of 30 mg/kg body weight/day during 3 or 7 days increased significantly statokinetic tolerance and produced a protective effect on the central nervous function against Coriolis acceleration.
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects*; D003312:Coriolis Force; D004341:Drug Evaluation; D004569:Electroencephalography; D006801:Humans; D007290:Inosine Diphosphate / Q000627:therapeutic use; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008606:Mental Processes / Q000187:drug effects; D009041:Motion Sickness / Q000517:prevention & control; D009963:Orotic Acid / Q000627:therapeutic use; D010889:Piracetam / Q000627:therapeutic use; D012601:Scopolamine / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D009963:Orotic Acid; D007290:Inosine Diphosphate; D012601:Scopolamine; D010889:Piracetam
vernacular_title: K farmakologicheskoĭ korrektsii sostoianiia tsentral'noĭ nervnoĭ sistemy pri deĭstvii uskoreniia Koriolisa.