Arginine vasopressin innoculates against age-related increases in sodium-dependent high affinity choline uptake and discrepancies in the content of temporal memory.
Systemic injections of arginine vasopressin (AVP, 0.08 pressor units/kg i.p.) to mature rats (10-13 months) trained on a positively reinforced timing task prevented the age-related discrepancies in the content of temporal memory and the increases in sodium-dependent high affinity choline uptake (SDHCU) in the frontal cortex observed in control rats when the rats became aged (27-30 months). AVP administration had no effect on muscarinic receptor density as measured by [3H]quinuclidinyl benzilate (QNB) binding or on choline acetyltransferase (ChAT) levels in either the hippocampus or the frontal cortex.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects; D002794:Choline / Q000378:metabolism*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D012964:Sodium / Q000502:physiology*
D001127:Arginine Vasopressin; D012964:Sodium; D002794:Choline