The effect of topical cyclosporin A on the rabbit cornea. A clinical and electron microscopic study.
To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.
D000818:Animals; D002368:Castor Oil; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D065306:Corneal Injuries; D003524:Cyclosporins / Q000494:pharmacology* / Q000627:therapeutic use; D000431:Ethanol; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D012997:Solvents; D014945:Wound Healing / Q000187:drug effects; D014949:Wounds, Nonpenetrating / Q000188:drug therapy
D003524:Cyclosporins; D012997:Solvents; D000431:Ethanol; D002368:Castor Oil