[S phase fraction and immunohistologic demonstration of the epithelial marker MAM-6 in orofacial tumors].
Tissue samples of 9 leukoplakias, 19 oral squamous cell carcinomas, 9 basaliomas and 6 specimens of normal oral mucosa were labeled with 3H-thymidine using an in vitro technique; the size of the S-phase fraction was determined histoautoradiographically. Whereas leukoplakias (with or without dysplasia) showed an homogeneous growth pattern, carcinomas and basaliomas demonstrated significantly higher proliferative activity in the tumor periphery. In the basaliomas the pallisade cells showed significantly higher indices than the polygonal cells. The proliferative potential of the oral squamous cell carcinomas is high compared to other neoplasias and depends on the grade and type of growth. The epithelial marker MAM-6 detected immunohistologically on the same tissue, showed a stronger expression in oral carcinomas than in leukoplakias. A direct relationship between the intensity of antigen expression and the proliferative behaviour (size of the S-phase fraction) was not detectable.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D002280:Basal Cell Carcinoma / Q000032:analysis / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000473:pathology; D002455:Cell Division; D005153:Facial Neoplasms / Q000032:analysis* / Q000473:pathology; D005260:Female; D006801:Humans; D007399:Interphase; D007700:Kinetics; D007972:Leukoplakia, Oral / Q000032:analysis / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000032:analysis* / Q000473:pathology; D018396:Mucin-1
D008565:Membrane Proteins; D018396:Mucin-1
S-Phasenfraktion und immunhistologischer Nachweis des Epithelmarkers MAM-6 in orofazialen Tumoren.