title: Elevated temperature produces cystine depletion in cystinotic fibroblasts.
abstract: Increasing the incubation temperature of cystinotic fibroblasts to 40 or 43 degrees C produces a 70-80% decrease in lysosomal cystine content within 24-48 h. This effect is probably mediated by an altered substrate affinity for another lysosomal transport protein.
mesh_terms: D002478:Cells, Cultured; D003540:Cystathionine / Q000378:metabolism; D003553:Cystine / Q000378:metabolism*; D003554:Cystinosis / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008715:Methionine / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D013696:Temperature
chemical_list: D003540:Cystathionine; D003553:Cystine; D008715:Methionine