Short-term effect of malathion on rats' blood glucose and on glucose utilization by mammalian cells in vitro.
Blood glucose increased in rats treated with a single ip dose of malathion (650 mg/kg). This effect was observed in the first hour of treatment, reached a 2.2-fold peak after 2 hr, and decreased after 4 hr. Malathion (20 micrograms/ml) caused a decrease of glucose utilization in IB-RS-2 cells treated for 8 hr. This effect was observed as early as 30 min after treatment and was time-dependent.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D013997:Time Factors
D001786:Blood Glucose; D005947:Glucose; D008294:Malathion