Barrel rotation and prostration by vasopressin and nicotine in the vestibular cerebellum.
The aim of this study was to determine whether the primary sites for the action of vasopressin and nicotine in producing barrel rotation and prostration in rats were located in the modular cerebellum, i.e., lobule X. When arginine vasopressin was administered into either the fourth ventricles or directly into the nodular cerebellum via chronically implanted cannulae, the rats displayed intermittent barrel rotation and clonic convulsions. The administration of nicotine into the same areas resulted in prostration, atonia and, occasionally, clonic convulsions. A few days after the nodular cerebellum was lesioned with kainic acid, the motor disturbances resulting from either agent were virtually abolished. Histologic studies revealed that kainic acid had destroyed Purkinje and other large neurons, but had left the granular neurons relatively intact. The administration of procaine into either the fourth ventricles or nodular cerebellum blocked the behavioral responses of either vasopressin or nicotine given into the fourth ventricles. It was concluded that the nodular cerebellum is a primary site for the motor disturbances produced by vasopressin and nicotine.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002531:Cerebellum / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D007608:Kainic Acid / Q000633:toxicity; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001127:Arginine Vasopressin; D009538:Nicotine; D007608:Kainic Acid