Colitis caused by non-steroidal anti-inflammatory drugs.
Four cases of acute proctocolitis associated with non-steroidal anti-inflammatory drug therapy are presented. The drugs implicated were flufenamic acid, mefenamic acid, naproxen and ibuprofen. After resolution of symptoms and signs of proctocolitis three of the four patients were subsequently rechallenged with the implicated drug: in each there was a rapid relapse.
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003092:Colitis / Q000139:chemically induced*; D005260:Female; D005439:Flufenamic Acid / Q000009:adverse effects; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D008528:Mefenamic Acid / Q000009:adverse effects; D009288:Naproxen / Q000009:adverse effects; D011350:Proctocolitis / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008528:Mefenamic Acid; D009288:Naproxen; D005439:Flufenamic Acid; D007052:Ibuprofen