Properties of microcytic caprine carrier red blood cells: their preparation and in vivo survival.
Dialysis encapsulation was used to prepare caprine-carrier RBC. Optimal conditions for encapsulation are described in which 23% of added [14C]sucrose was entrapped. Carrier RBC were stable in vitro releasing only 5% of entrapped substance in 24 hour. Injected-carrier RBC circulated with a 47-day half-life. Although markedly smaller in size (10 fl vs 15 fl), caprine-carrier RBC were morphologically identical to normal RBC.
D000818:Animals; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000502:physiology* / Q000648:ultrastructure; D006041:Goats / Q000097:blood*; D006207:Half-Life; D008855:Microscopy, Electron, Scanning; D009996:Osmotic Fragility; D012044:Regression Analysis