Myeloencephalopathy resembling Alexander's disease in a Scottish terrier dog.
Diffuse degenerative myeloencephalopathy resembling Alexander's disease in a tetraparetic 9-month-old Scottish terrier dog is described. There were widespread deposits of Rosenthal fibers throughout brain and spinal cord in subpial, subependymal, perivascular and white matter regions. A diffuse proliferation of pleomorphic astrocytes in the white matter and subependymal areas was also seen. Demyelination was not a salient feature of the disease.
D000818:Animals; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D013577:Syndrome