Prevention of ammonia-induced brain edema in dogs infused with a branched-chain amino acid solution.
Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier resulted in a marked rise in intracranial pressure (ICP). The preventive effect of a branched-chain amino acid (BCAA) solution on ammonia-induced brain edema was tested by measuring ICP and brain water content. The BCAA solution apparently prevented ammonia-induced brain edema, indicating that BCAA accelerated ammonia detoxification in the brain.
D000085:Acetates / Q000037:antagonists & inhibitors / Q000378:metabolism; D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D000818:Animals; D001929:Brain Edema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004285:Dogs
D000085:Acetates; D000597:Amino Acids, Branched-Chain; C018824:ammonium acetate