Vitamin A can prevent genetic damage induced by benzo(a)pyrene to the bone marrow cells of mice.
Vitamin A and its analogues are now known to be of help in the prevention of cancer. One of the mechanisms by which cancer can occur is due to the damage to DNA. Hence, we have investigated the effect of vitamin A on genetic damage induced by benzo(a)pyrene, a known mutagen and co-carcinogen, to the bone marrow cells of mice. The results suggest that vitamin A can prevent genetic damage caused by benzo(a)pyrene.
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D001854:Bone Marrow Cells; D002455:Cell Division; D051379:Mice; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D001564:Benzo(a)pyrene