Comparative physiological disposition of two nitrofuran anti-microbial agents.
The physiological disposition of two nitrofuran derivatives used as antimicrobial agents for the treatment of acute infectious diarrhoea was evaluated in humans and animals. Upon administration of a single oral dose (600 mg) of nifurzide or nifuroxazide, no unchanged parent drug was detected in human blood or urine. In rats given 14C-nifurzide and 14C-nifuroxazide at a dose of 10 mg kg-1, 5 per cent and 17 per cent of the dose of nifurzide and nifuroxazide, respectively, were excreted in urine over a 48-hour period. None of this radioactivity was present as unchanged drug, indicating that renal excretion of both drugs occurs as metabolites. In the faeces 20 per cent of the radioactivity recovered was associated with unchanged nifuroxazide as compared with 100 per cent for nifurzide. Whole body autoradiography using rats showed that after oral administration of 14C-nifurzide and 14C-nifuroxazide, most of the radioactivity remained in the gastrointestinal lumen.
D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001646:Bile / Q000032:analysis; D005243:Feces / Q000032:analysis; D006801:Humans; D062385:Hydroxybenzoates / Q000378:metabolism* / Q000652:urine; D008297:Male; D009581:Nitrofurans / Q000378:metabolism* / Q000652:urine; D051381:Rats; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D062385:Hydroxybenzoates; D009581:Nitrofurans; C013150:nifuroxazide; C029924:nifurzide