Experimental study of vascularized tibiofibula graft in inbred rats: a preliminary report.
An experimental study of vascularized tibiofibula grafts in inbred rats was performed. Roentgenologic and histologic changes of the grafted bone in the first seven postoperative weeks were especially investigated. After preliminary experiments on the vascular anatomy of the lower limbs of rats, tibiofibular vascularized grafts with femoral artery and vein were utilized in Fischer strain F-344 rats. The rate of bony union in the vascularized graft group was superior to that in the nonvascularized control groups. Fluorochrome-labeling studies of the grafted bone at the mid-diaphysis showed active periosteal new bone formation, following the vascularized graft. In contrast, normal tibial bone growth at the mid-diaphysis was mainly endosteal. However, both vascularized graft and normal bone demonstrated evidence of a "drift phenomenon" in the direction of growth. Since the life cycle of the rat is very short, compared with other laboratory animals, this experimental model may be useful in investigating the postoperative course of vascularized bone grafts with a short follow-up period.
D000818:Animals; D001158:Arteries / Q000601:surgery; D005360:Fibula / Q000098:blood supply / Q000473:pathology / Q000637:transplantation*; D006984:Hypertrophy; D008866:Microsurgery / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D013977:Tibia / Q000098:blood supply / Q000473:pathology / Q000637:transplantation*; D014945:Wound Healing