Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor.
cDNAs encoding the mouse insulin-like growth factor II (IGF-II) precursor have been isolated from a placental library and sequenced. Mouse prepro-IGF-II is predicted to be 180 amino acids and has 84% and 97% identity with human and rat IGF-II precursors, respectively. There are two prepro-IGF-II transcripts in mouse placenta; the major transcript is 3850 bases and the minor one is 4800 bases. Prepro-IGF-II mRNA cannot be detected in adult mouse liver, but it is readily detected in adult human liver, indicating that there are differences in the regulation of expression of the IGF-II gene in the liver of adult mice and human beings.
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D010920:Placenta; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013002:Somatomedins / Q000235:genetics*
D011498:Protein Precursors; D013002:Somatomedins; D007335:Insulin-Like Growth Factor II; D004247:DNA