title: Staphylococcus epidermidis ventriculitis treated with vancomycin and rifampin.
abstract: Two cases of ventriculitis with Staphylococcus epidermidis that failed on therapy with an antistaphylococcal penicillin are presented. Both infections responded to a combination of intravenous and intraventricular vancomycin and rifampin. Vancomycin and rifampin represent an important antibiotic regimen for the management of resistant infections of the central nervous system, especially with those due to S. epidermidis or methicillin-resistant Staphylococcus aureus.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002552:Cerebral Ventricles; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D002648:Child; D006259:Craniocerebral Trauma / Q000150:complications; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007276:Injections, Intraventricular; D008297:Male; D012293:Rifampin / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D012293:Rifampin