[Role of G0- and G1-splenocytes and antigen-binding lymphocytes in the production of antigen-dependent nonspecific immunoglobulins].
Immunization of irradiated and syngeneic splenocyte-treated CBA mice with bovine red blood cells stimulated the formation of both antigen-producing cells (APC) and antigen-dependent nonspecific immunoglobulin-producing cells (NIGPC). The injection of G0-cell-enriched, instead of normal, splenocytes (together with bovine RBC) to irradiated mice reduced by half the production of antigen-dependent NIGPC. Thus, it is evident, that some of them are formed from preexisting blast cells (G1). An additional removal of antigen-binding cells (ABC) from G0 lymphocyte population produced a still greater reduction in NIGPC formation (the increment was 92.3% lower than in the control). It is concluded that antigen-dependent NIGPC are formed both due to specific antigen-stimulation of G0 cells aid to nonspecific stimulation of blast cells with factors produced by antigen-stimulated T-cells.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D005260:Female; D007136:Immunoglobulins / Q000276:immunology*; D007399:Interphase; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology* / Q000276:immunology
D000941:Antigens; D007136:Immunoglobulins
Rol' G0- i G1-splenotsitov i antigen-sviazyvaiushchikh limfotsitov, produtsiruiushchikh antigenzavisimye nespetsificheskie immunoglobuliny.