A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.
We have used multilocus analysis to exclude the cystic fibrosis locus from six polymorphic DNA markers covering most of chromosome 19. A substantial increase in the confidence for exclusion was obtained using the computer programme LINKAGE compared to analysis of pairwise lod scores. A structured approach to the analysis of linkage to autosomal recessive inherited diseases where the biochemical defect is not known is described.
D002648:Child; D002888:Chromosomes, Human, Pair 19; D003550:Cystic Fibrosis / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D009693:Nucleic Acid Hybridization; D012984:Software