DNA-mediated transfer of a human gene required for low-density lipoprotein receptor expression and for multiple Golgi processing pathways.
Transfection of a hamster cell mutant with human DNA corrected both the low-density lipoprotein receptor-deficient phenotype and the multiple glycosylation defects of the cells. Independently transfected colonies contained a small set of common human DNA fragments. These fragments may correspond to the human analog of a single gene required for several different Golgi processing pathways.
D000818:Animals; D001483:Base Sequence; D006224:Cricetinae; D004247:DNA / Q000378:metabolism*; D005786:Gene Expression Regulation; D005796:Genes; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D009154:Mutation; D011973:Receptors, LDL / Q000235:genetics*; D014162:Transfection
D011973:Receptors, LDL; D004247:DNA