[Effect of tomicide and the cell wall biopolymers of Streptococcus sp. Thom-1606 on mast cell degranulation].
The influence of tomicide and biopolymers obtained from the cell wall of Streptococcus sp. TOM-1606 on the degranulation of mast cells was studied. Among the biopolymers of the streptococcal cell-wall polysaccharide was shown to induce the highest destruction of mast cells (14.84 +/- 6.8%). The alteration of mast cells under the effect of peptidoglycan and teichoic acid was mildly positive (11.85 +/- 5.8% and 12.1 +/- 6.2%). At the same time the destruction induced by the complex of noninfectious allergen and the patient's serum was 33.2 +/- 3.8% respectively. Other preparations induced destruction on the level of spontaneous degranulation. The study of the action of the allergen-antibody complex in combination with tomicide and biopolymers obtained from the cell wall of Streptococcus sp. TOM-1606 revealed a decrease in the rate of mast cell degranulation almost to the background level (24.7 +/- 0.55% for the allergen-antibody complex and 8.4 +/- 4.2% to 11.8 +/- 5.3% for streptococcal biopolymers).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000936:Antigen-Antibody Complex / Q000276:immunology; D001430:Bacteriocins; D001704:Biopolymers; D002452:Cell Count / Q000187:drug effects; D002473:Cell Wall / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D051381:Rats; D013291:Streptococcus / Q000276:immunology / Q000472:pathogenicity*
D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex; D001430:Bacteriocins; D001704:Biopolymers; C026129:tomicide
Vliianie tomitsida i biopolimerov kletochnoĭ stenki Streptococcus sp. TOM-1606 na degranuliatsiiu tuchnykh kletok.