Changes in gastric mucosal blood flow in patients with duodenal ulcer following proximal selective vagotomy (PSV).
Pentagastrin-stimulated mucosal blood flow and acid secretion were studied in duodenal ulcer patients by means of the 99mTc-4-methylaminophenazone clearance method in the active and inactive phases of the disease, and before and after proximal selective vagotomy. The results suggest that the mucosal blood flow--acid secretion ratio in the patients differs from that found in normosecretory subjects. In duodenal ulcer patients in the inactive phase, the secretory capacity of the gastric mucosa was found to be significantly elevated as compared with the mucosal blood flow. In the active phase of the disease the mucosal blood flow increased in parallel with acid secretion. Following proximal selective vagotomy the normal blood flow-secretion ratio was restored. Comparison of the pre- and postoperative gastric mucosal blood flow and secretion values via the 99mTc-methylaminophenazone clearance technique proved useful for the evaluation of the effectiveness of vagotomy.
D000328:Adult; D004177:Dipyrone / Q000031:analogs & derivatives; D004381:Duodenal Ulcer / Q000503:physiopathology / Q000601:surgery*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply*; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010418:Pentagastrin; D047069:Pyrazolones; D012039:Regional Blood Flow; D013667:Technetium; D014629:Vagotomy, Proximal Gastric
D015609:Organotechnetium Compounds; D047069:Pyrazolones; C034867:technetium Tc 99m-4-methylaminophenazone; D004177:Dipyrone; D013667:Technetium; D010418:Pentagastrin