Beneficial effects of polyunsaturated fatty acids in partially nephrectomized rats.
Evening primrose oil, safflower oil, and salmon oil, all with high polyunsaturated fatty acid content, were fed to partially nephrectomized rats; the effects were compared to those of feeding beef tallow. All three oils had favorable effects on progression of renal failure, salmon oil on kidney histology as well. The changes induced in platelet production of thromboxane A2, and in the renal production of various eicosanoids may explain the protective role of these oils.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D008055:Lipids / Q000097:blood; D009392:Nephrectomy; D011507:Proteinuria / Q000178:diet therapy; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D003404:Creatinine