[Macro- and microhemodynamics and transcapillary fluid exchange in skeletal muscle and the intestines after intra-arterial injection of obsidan and corinfar].
In the cat autoperfused and hemodynamically isolated m. gastrocnemius and small intestine, i.a. infusion of corinphare enlarged arterial vessels in both organs, increased venous outflow in the muscle and altered it in the intestine, decreased pre- and postcapillary resistance as well as hydrostatic pressure in both organs which led to absorption of fluid from the interstitium and increased the capillary filtration coefficient (CFC). Administration of obsidan into the skeletal muscle vascular bed induced a decrease of the perfusion pressure and precapillary resistance whereas its infusion into the intestine entailed both analogous and contrary changes of these parameters. Obsidan reduced venous outflow, increased the CFC, postcapillary resistance and capillary hydrostatic pressure, thus entailing a fluid filtration into the interstitial space.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects; D002415:Cats; D006439:Hemodynamics / Q000187:drug effects; D006874:Hydrostatic Pressure; D007269:Injections, Intra-Arterial; D007421:Intestine, Small / Q000098:blood supply*; D009132:Muscles / Q000098:blood supply*; D009543:Nifedipine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D011433:Propranolol; D009543:Nifedipine
Makro- i mikrogemodinamika, transkapilliarnyĭ obmen zhidkosti v skeletnoĭ myshtse i kishechnike pri vnutriarterial'nom vvedenii obzidana i korinfara.