Disturbances in hepatic heme metabolism in rats administered alkyl halides.
Liver tissue from rats administered 13 different alkyl halides and 4 other hepatotoxins were assayed for indices of hepatic heme synthesis. These included aminolevulinic acid (ALA)-dehydratase activity, porphyrin content, microsomal cytochrome P-450 and reduced glutathione content. Consistent decreases in ALA-dehydratase activity (14 of 17 compounds) and cytochrome P-450 content (14 of 17 compounds) were found. Significant changes in glutathione and porphyrin content also occurred after exposure to some compounds, but were not consistent. Alkyl halides are a class of toxicologically important compounds which have been found to exert an influence on hepatic heme synthesis.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis / Q000378:metabolism*; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D006846:Hydrocarbons, Halogenated; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D000623:Porphobilinogen Synthase; D005978:Glutathione