5,7-Dihydroxytryptamine modifies excitability of rat dorsal raphe serotonergic neurons in vitro.
Activity of serotonergic dorsal raphe neurons was recorded intracellularly in a brainstem slice preparation from rats before and after local microperfusion of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT). The initial effect of the drug consisted of a transient hyperpolarization. Over 1-2 h after drug application there was a gradual decrease in efficacy of a hyperpolarizing current pulse to evoke a transient rectification. Also, action potentials in some cells failed to evoke a spike after-hyperpolarization. These effects are related to the neurodegenerative action of 5,7-DHT.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
D004102:Dihydroxytryptamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin