Release of cytolytic factor(s) by murine macrophages in vitro on treatment with cis-platin.
Supernatants collected from macrophage monolayers treated with cis-Platin lyse the tumor cells in vitro. In addition the cis-Platin treated macrophages are observed to show increased binding of tumor cells and also have a cytostatic effect on them. It is proposed that cis-Platin treatment of macrophages results in the release of cytolytic factor(s) with potent capacity to lyse the tumor cells in vitro.
D000818:Animals; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D003601:Cytotoxicity Tests, Immunologic; D003603:Cytotoxins / Q000276:immunology*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains
D003603:Cytotoxins; D002945:Cisplatin