Comparison in rabbits of chole-scintigraphic properties of several 99mTc-IDA derivatives.
Pathways and kinetics of excretion were compared to four 99mTc-IDA derivatives in healthy rabbits of both sexes. Assessment of differences between the compounds was based upon: plasma clearance, characteristics of time-activity curves measured scintigraphically over the liver (time of the peak Tmax; time for decline of activity to half the peak value-T50%), and hepatocytic mean transit time (MTT) as derived after deconvolution of the hepatic time-activity curve. Hepatocyte transit time was short and similar to 99mTc-complexes of Mebrofenin, 2,4-diethyl IDA (HEPIDA) and 3-iodo-2,6-diethylphenylcarbamoylmethyliminodiacetic acid (JODIDA); it was evidently longer for 99mTc-p-butyl-IDA (BIDA). 99mTc-HEPIDA displayed significant urinary elimination; the remaining three compounds were excreted practically completely via the biliary route. It is concluded that optimal parameters were displayed by 99mTc-Mebrofenin and 99mTc-JODIDA.
D000814:Aniline Compounds; D000818:Animals; D001646:Bile / Q000378:metabolism; D001652:Bile Ducts / Q000000981:diagnostic imaging*; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging*; D005998:Glycine; D007098:Imino Acids; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D012737:Sex Factors; D013667:Technetium / Q000378:metabolism; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; C051086:technetium Tc 99m 2,6-diethyl-3-iodo-HIDA; D013667:Technetium; C034837:technetium Tc 99m mebrofenin; D005998:Glycine