Orosomucoid as the accelerator of hepatic fibrosis.
The administration of orosomucoid to rats with chronic liver injury accelerated hepatic fibrosis. An increase of hepatic fibres was seen histologically and the content of hydroxyproline in the liver collagen fraction increased. Moreover, the incorporation of 3H-proline into the collagen fraction of injured liver was increased by the administration of orosomucoid.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D005355:Fibrosis; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D009961:Orosomucoid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009961:Orosomucoid; D003094:Collagen; D006909:Hydroxyproline