title: Increased 2nd trimester hemoglobin concentration in pregnancies later complicated by hypertension and growth retardation. Early evidence of a reduced plasma volume.
abstract: Second-trimester hemoglobin (Hb) concentration was measured in 1535 pregnancies. Mean Hb concentration was significantly increased in women who developed pregnancy-induced hypertension (PIH) in the last trimester before the 37th week (p less than 0.01). A similar trend was also observed in nulliparous women who gave birth to infants with a birthweight below the 10th percentile, especially in smokers. The highest Hb concentrations were found in women with both PIH and intra-uterine growth retardation (IUGR). These findings are in agreement with previous observations in smaller studies and indicate that a reduced plasma volume may already be present in the second trimester, before PIH and/or IUGR appear.
mesh_terms: D001810:Blood Volume; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood*; D006454:Hemoglobins / Q000032:analysis* / Q000502:physiology; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000503:physiopathology; D011263:Pregnancy Trimester, Third; D012907:Smoking
chemical_list: D006454:Hemoglobins