Efficacy of toltrazuril against intestinal and hepatic coccidiosis in rabbits.
The anticoccidial effect of toltrazuril (Bay Vi 9142) against Eimeria flavescens, E. intestinalis, E. magna, E. perforans and E. stiedai was tested in experimentally-infected rabbits. Continuous administration of 10-15 p.p.m. of the drug in the drinking water was highly effective in reducing oocyst output of all five species and in preventing clinical signs and macroscopic lesions. Sporulation of excreted oocysts was not affected. After 5 weeks of medication, no negative influence was noted on zootechnic performance of growing healthy rabbits. Medication of rabbits with 25 p.p.m. only during schizogony or gamogony (2 days of treatment, repeated after 5 days) quickly reduced clinical signs and oocyst output. When administered during late schizogony or gamogony, toltrazuril allowed development of immunity against reinfection with homologous species.
D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004539:Eimeria / Q000187:drug effects; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D011817:Rabbits; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*
D014227:Triazines; C036670:toltrazuril