title: The use of hydroxocobalamin in the Schilling test.
abstract: Hydroxocobalamin and cyanocobalamin have been compared as the 'flushing dose' in the Schilling test. In healthy, haematologically normal subjects excretion of the test dose was greater following a hydroxocobalamin flushing dose than following a cyanocobalamin flushing dose, and to a lesser extent this was also true in patients requiring investigation. There were occasional discrepant results, but in general it appears that, although reference values differ, hydroxocobalamin is a suitable replacement for cyanocobalamin in the Schilling test.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004341:Drug Evaluation; D005215:Fasting; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012546:Schilling Test / Q000379:methods*; D014805:Vitamin B 12 / Q000032:analysis; D014806:Vitamin B 12 Deficiency / Q000175:diagnosis / Q000378:metabolism
chemical_list: D014805:Vitamin B 12; D006879:Hydroxocobalamin