Retinoic acid and butylated hydroxyanisole inhibit promoter-enhanced transformation in vitro.
The inhibitory effects of some antipromoters were studied using a two-stage transformation assay system in vitro with 3-methylcholanthrene (3-MC)-initiation and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promotion in BALB 3T3 cells. Butylated hydroxyanisole (BHA), a phenolic antioxidant, inhibited TPA-enhanced transformation in a dose-dependent manner, but butylated hydroxytoluene (BHT) did not. Among the three antipromoters tested, retinoic acid (RA) was the most effective inhibitor.
D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D008748:Methylcholanthrene; D013755:Tetradecanoylphorbol Acetate; D014212:Tretinoin / Q000494:pharmacology*
D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D008748:Methylcholanthrene; D014212:Tretinoin; D013755:Tetradecanoylphorbol Acetate