Antihypertensive activity of arylidenaminoguanidine derivatives.
The synthesis of new benzylidenaminoguanidine compounds is described. Some of these compounds were tested for antihypertensive activity in conscious unrestrained spontaneously hypertensive rats. The compounds examined possess a significant antihypertensive activity, qualitatively different from that of clonidine. For the tested compounds, the absence of the transient rise in blood pressure, which appears immediately after administration of clonidine-like drugs, is noteworthy.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D001597:Benzylidene Compounds; D006146:Guanidines