[Dependence of the specific activity of antistaphylococcal immunoglobulin on the degree of its fragmentation].
In vitro experiments have revealed no perceptible decrease in the content of antitoxic antibodies to alphastaphylolysin in the preparations of antistaphylococcal immunoglobulin, containing 13-50% of Fab-fragments. These data confirm the necessity of controlling the molecular composition of the preparations of antistaphylococcal IgG by physico-chemical methods with the aim to evaluate their quality, as the fragmented preparations are rapidly eliminated from a human body.
D000918:Antibody Specificity; D006460:Hemolysin Proteins / Q000032:analysis; D007140:Immunoglobulin Fab Fragments / Q000032:analysis / Q000276:immunology*; D007136:Immunoglobulins / Q000032:analysis / Q000276:immunology*; D013210:Staphylococcus / Q000276:immunology*; D013329:Structure-Activity Relationship
D006460:Hemolysin Proteins; D007140:Immunoglobulin Fab Fragments; D007136:Immunoglobulins; C006603:antistaphylolysin
Izuchenie zavisimosti spetsificheskoĭ aktivnosti antistafilokokkovogo immunoglobulina ot stepeni fragmentatsii.