The behavior of juvenile Fasciola hepatica.
The behavioral repertoire of the infective stage of Fasciola hepatica was qualitatively characterized. During activation, a primary activity was the emptying of the ceca by peristaltic-like contractions. Emergence behavior comprised coordinated patterns of body movement and sucker activity specifically directed at disruption of the ventral plug. The stimulus specificity of the emergence response for glycine-conjugated cholic acid and the log dose-effect relationship of this response with glycocholic acid suggested a receptor-mediated sensory recognition. Extracts from the duodenum (departure organ) and the liver (arrival site) significantly affected the rate of locomotion and the orientation of the migratory stage. The evidence for orientation in the migrating stages is unequivocal, but the mechanisms by which they orient are unclear.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D004386:Duodenum; D005210:Fasciola hepatica / Q000187:drug effects / Q000502:physiology*; D006000:Glycocholic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008099:Liver; D009068:Movement / Q000187:drug effects; D009949:Orientation; D012701:Serotonin / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology
D001647:Bile Acids and Salts; D014020:Tissue Extracts; D012701:Serotonin; D006000:Glycocholic Acid