Antigenic variation among human strains of influenza C virus detected with monoclonal antibodies to gp88 glycoprotein.
Antigenic variation among influenza C virus strains was investigated with monoclonal antibodies against gp88 glycoprotein. Seven monoclonal antibodies obtained were tentatively classified into two groups, A and B. The group A antibodies had hemagglutination inhibition (HI), hemolysis inhibition and neutralization activities whereas the group B antibodies possessed none of them. A comparison of antigenicity among 15 human strains with these antibodies in radioimmunoprecipitation and HI tests showed that the regions recognized by the group A antibodies undergo considerable changes, whereas those by group B are conserved among the strains.
D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D003429:Cross Reactions; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics*; D006385:Hemagglutination Inhibition Tests; D006461:Hemolysis; D006801:Humans; D009982:Gammainfluenzavirus / Q000235:genetics* / Q000276:immunology; D009500:Neutralization Tests; D009975:Orthomyxoviridae / Q000235:genetics*; D013045:Species Specificity; D014764:Viral Proteins
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D006023:Glycoproteins; D014764:Viral Proteins; C045555:gp88 protein, Influenzavirus C