Effects of O,O,O-tri-n-alkyl phosphorothioates on acetaminophen-induced hepatotoxicity in rats.
Four homologous O,O,O-tri-n-alkyl phosphorothioates were tested to prevent liver damage induced by acetaminophen in fed and starved rats. In fed rats, trimethyl, triethyl and tri-n-propyl esters prevented effectively the increase of serum transaminase activities. In starved rats, however, tri-n-propyl ester became ineffective and tri-n-butyl ester showed a slightly protective effect.
D000082:Acetaminophen / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D008297:Male; D063086:Organothiophosphates / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D000637:Transaminases / Q000097:blood
D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D000082:Acetaminophen; D000637:Transaminases