The effect of ethanol and sex on radial arm maze performance in rats.
A daily dose of 1.5 g/kg of ethanol interfered with radial arm maze performance in rats. Ethanol inhibited the acquisition of a new win-shift response to obtain a food reward, especially when a previously learned response was present. This effect was greater in females than in males. Ethanol appears to suppress flexibility in the development of optimal performance of goal-directed behavior.
D000818:Animals; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D007858:Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D012727:Sex Characteristics
D000431:Ethanol