[Abnormal effect of nitrosation inhibitors in human gastric juice].
The paper discusses the effect of vitamins C and E and Plantaglucide on nitroso compounds yield in the course of nitrosation of amines in human gastric juice. The study group included 56 subjects. The above drugs capable of inhibiting in vitro nitrosation produced an anomalous effect in gastric juice of some subjects, i.e. potentiated nitroso compounds yield in nitrosation of amines by sodium nitrite. The said action of vitamins C and E was apparent in dimethylamine and amidopyrine nitrosation but it was not in morpholine nitrosation. Sharply increased levels in nitroso compounds were observed in some mice fed precursors of nitroso compounds in combination with vitamin C and Plantaglucide. These data point to an anomalous effect of the drugs on the body.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003864:Depression, Chemical; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009573:Nitrites; D009602:Nitrosamines / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology; D011620:Psyllium / Q000494:pharmacology*; D012977:Sodium Nitrite; D014810:Vitamin E / Q000494:pharmacology*
D009573:Nitrites; D009602:Nitrosamines; D010936:Plant Extracts; D014810:Vitamin E; D011620:Psyllium; D012977:Sodium Nitrite; D001205:Ascorbic Acid
Anomal'nyĭ éffekt ingibitorov nitrozirovaniia pri deĭstvii ikh v srede zheludochnogo soka liudeĭ.