Conjunctival basophil hypersensitivity in the guinea pig.
We have induced a basophil hypersensitivity reaction in the upper tarsal conjunctiva of the guinea pig by methods that induce a comparable basophil hypersensitivity reaction in the flank. The inflammatory cell infiltrate in this reaction contained large numbers of basophils and eosinophils with accompanying neutrophils and monocytes. Ocular tissue can serve as a priming site for systemic immunization and also for elicitation of a secondary flare after challenge with antigen. Very few inflammatory cells were observed in the cutaneous epithelium of either primary or secondary flares. In contrast, the mucosal stroma and epithelium contained large numbers of inflammatory cells (basophils, eosinophils, and neutrophils), suggesting directed cellular movement onto the ocular surface. The lesion of ocular basophil hypersensitivity in the guinea pig has features in common with two human eye diseases, vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. We hypothesize that the acute basophil hypersensitivity reactions of the conjunctiva are transformed into chronic inflammatory and proliferative states in vernal conjunctivitis and giant papillary conjunctivitis.
D000818:Animals; D001491:Basophils / Q000276:immunology*; D003228:Conjunctiva / Q000276:immunology* / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006168:Guinea Pigs; D006433:Hemocyanins / Q000276:immunology; D006967:Hypersensitivity / Q000473:pathology; D012882:Skin Tests
D006433:Hemocyanins