Oxyntic mucosa histology in omeprazole-treated patients suffering from duodenal ulcer or Zollinger-Ellison syndrome.
Endoscopic biopsies were taken from the oxyntic mucosa in patients with duodenal ulcer (DU) before and after 4 weeks of treatment with omeprazole. Biopsies were also obtained from Zollinger-Ellison (ZE) patients before and during treatment with omeprazole; these patients had previously failed to respond to other therapies aiming at reducing gastric acid secretion. Healthy volunteers served as controls. Light-microscopic studies of biopsy sections revealed superficial gastritis in most of the patients. Endocrine cell volume density (that is, the percentage of mucosal volume occupied by endocrine cells) was 0.3% in the DU patients and 0.7% in the ZE patients before omeprazole treatment. No significant change occurred during omeprazole treatment, which in the ZE patients continued for up to 21 months. In the controls, 0.3% of the mucosal volume was occupied by endocrine cells. Parietal cell volume density was about 15% in both the DU patients and in the controls; in the ZE patients, slightly but not significantly higher values were recorded. No significant change was observed during omeprazole treatment.
D000328:Adult; D001706:Biopsy; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010295:Parietal Cells, Gastric / Q000473:pathology*; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy*
D009853:Omeprazole