Acute leukemia with t(4;11) following treatment for breast cancer.
We report the case of a 51-year-old woman presenting t(4;11) acute undifferentiated leukemia 19 months after initiation of adjuvant radio-chemotherapy for a breast cancer. Morphology of the blasts was FAB L2 and cytochemical and immunological studies were in favor of an undifferentiated leukemia. A possible relationship between t(4;11) leukemia and exposure to carcinogens is discussed.
D000208:Acute Disease; D000230:Adenocarcinoma / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D008875:Middle Aged; D014178:Translocation, Genetic