[Drug allergy to antibiotics in newborn and nursing infants].
A total of 3890 medical histories of women in childbirth in one of the maternity hospitals of Novosibirsk in 1984 were analyzed for comparison of the relative frequency of drug therapy and allergy to the drugs used during pregnancy and after delivery. The risk of drug allergy in the women treated with drugs during pregnancy increased 3 times and amounted to 3.5 per cent against that in the pregnant women not treated with drugs. In addition, 62 newborns, 28 infants and 90 mothers were examined for antibiotic allergy (860 examinations) with the use of a modified thermistographic unit. It was shown that sensitization was more frequent in the infants of the women with allergy in the anamneses and treated with antibiotics during pregnancy or after delivery (75 per cent of the cases). Latent sensitization of the mothers also played a significant role in development of antibiotic allergy in the newborns and infants (40 per cent of the cases). Possible sensitization of these infants through milk of the women treated with antibiotics during pregnancy or nursing was shown.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000906:Antibodies / Q000032:analysis; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization; D007159:Immunologic Tests; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000187:drug effects / Q000276:immunology; D011247:Pregnancy; D012306:Risk; D012882:Skin Tests
D000900:Anti-Bacterial Agents; D000906:Antibodies
Lekarstvennaia allergiia k antibiotikam u novorozhdennykh i deteĭ grudnogo vozrasta.