Bioassay for SF 86-327, a new antifungal agent.
A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.
D000935:Antifungal Agents / Q000097:blood*; D001681:Biological Assay / Q000379:methods; D006801:Humans; D007700:Kinetics; D009281:Naphthalenes / Q000097:blood*; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine