Thromboembolic prophylaxis in hip fracture.
The effect of either heparin-dihydergot or heparin-acenocoumarin on the incidence of deep-vein thrombosis in the legs was studied in 181 women undergoing Ender nailing for intertrochanteric fracture of the femur. All the patients were screened with the 125-I-fibrinogen uptake test, confirmed by a bilateral ascending venogram. Deep-vein thrombosis developed in 40 per cent of the heparin-dihydergot group and in 61 per cent of the heparin-acenocoumarin group (p less than 0.015).
D000074:Acenocoumarol / Q000008:administration & dosage; D000368:Aged; D000369:Aged, 80 and over; D001858:Bone Nails; D004087:Dihydroergotamine / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005340:Fibrinogen; D006493:Heparin / Q000008:administration & dosage; D006620:Hip Fractures / Q000150:complications* / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes; D007482:Iothalamate Meglumine; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D011897:Random Allocation; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000517:prevention & control; D013997:Time Factors
D007457:Iodine Radioisotopes; D004087:Dihydroergotamine; D005340:Fibrinogen; D006493:Heparin; D000074:Acenocoumarol; D007482:Iothalamate Meglumine