[Increase in the damaging effect of free fatty acids on brain synaptosomes induced by vitamin E deficiency].
Using fluorescent probes it has been shown that free fatty acids cause depolarization of synaptosomes isolated from the rat brain. At the same time free fatty acids stimulated 45Ca2+ transport into synaptosomes. It has been demonstrated that synaptosomes isolated from the brain of E-deficient rats were more sensitive to the action of free fatty acids. Depolarization of synaptosomes isolated from the brain of both control and E-deficient rats were reduced by the addition of exogenous alpha-tocopherol.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000633:toxicity*; D066298:In Vitro Techniques; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*; D014811:Vitamin E Deficiency / Q000150:complications*
D005230:Fatty Acids, Nonesterified
Usilenie povrezhdaiushchego deĭstviia svobodnykh zhirnykh kislot na sinaptosomy mozga pri defitsite vitamina E.