title: A new location for the human adenine phosphoribosyltransferase gene (APRT) distal to the haptoglobin (HP) and fra(16)(q23)(FRA16D) loci.
abstract: The human adenine phosphoribosyltransferase gene (APRT) was mapped with respect to the haptoglobin gene (HP) and the fragile site at 16q23.2 (FRA16D). A subclone of APRT and a cDNA clone of HP were used for molecular hybridization to DNA from mouse-human hybrid cell lines containing specific chromosome 16 translocations. The APRT subclone was used for in situ hybridization to chromosomes expressing FRA16D. APRT was found to be distal to HP and FRA16D and was localized at 16q24, making the gene order cen-FRA16B-HP-FRA16D-APRT-qter.
mesh_terms: D000228:Adenine Phosphoribosyltransferase / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization; D010430:Pentosyltransferases / Q000235:genetics*
chemical_list: D006242:Haptoglobins; D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase