title: Age difference in pharmacokinetics of an amoxycillin trihydrate-15% formulation administered intramuscularly to ruminants.
abstract: Intramuscular administration of an amoxycillin trihydrate-15% formulation to three groups of animals revealed in preruminant calves (age 3-4 weeks) significant higher plasma peak drug concentrations and shorter biological half-lives than in 5-month-old ruminant calves and dairy cows. Differences in pharmacokinetics were related to age-difference in drug absorption capability at the injection site regarding the formulation.
mesh_terms: D000367:Age Factors; D000658:Amoxicillin / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007700:Kinetics
chemical_list: D000658:Amoxicillin