Scanning electron microscopic study of precancerous and cancerous pancreatic lesions induced by N-nitrosobis (2-oxopropyl) amine in Syrian golden hamsters.
Sequential alteration of Syrian golden hamster pancreatic ducts and ductules was investigated by scanning electron microscope during and subsequent to 10 weekly subcutaneous injections of N-nitrosobis (2-oxopropyl) amine (BOP). By examining surface morphology of ductal cells and resin casts of the secretory branches arising from the common duct, a series of lesions ranging from slight derangement of the luminal dimensions and loss of cilia to marked projections of "finger-like" processes accompanied by pleomorphism at the cellular and microvilli levels and increase in numbers of goblet cells could be established. A ductal histogenesis is proposed on the basis of the present scanning electron microscopic and earlier light microscopic findings.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D006965:Hyperplasia; D008647:Mesocricetus; D009602:Nitrosamines; D010183:Pancreatic Ducts / Q000648:ultrastructure*; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000648:ultrastructure*
D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine