Metyrapone-induced thermogenesis in cold- and heat-acclimated rats.
Metyrapone caused significant increase of VO2 in cold-acclimated rats, but not in warm controls and heat-acclimated rats. Plasma FFA decreased, while plasma glycerol increased in all groups. Glycerol increase was less in heat-acclimated rats than in other groups. FFA/glycerol molar ratio decreased most in cold-acclimated rats.
D000064:Acclimatization; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006358:Hot Temperature; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D005990:Glycerol; D008797:Metyrapone