Beneficial effect of taurine in rabbits with chronic congestive heart failure.
To examine the effect of daily treatment with taurine on improving the status of congestive heart failure (CHF), we used rabbits with artificially induced aortic regurgitation. Ten rabbits were treated daily with taurine (100 mg/kg by mouth) and eight with guanidinoethyl sulfonate (GES) (100 mg/kg by mouth) immediately after induction of aortic regurgitation. The cumulative mortality rate at 8 weeks in the taurine-treated CHF group was 10% (1 of 10) compared with 53% (16 of 30) in the nontreated CHF group and 75% (6 of 8) in the GES-treated CHF group (p less than 0.05). Although cardiac function (max dP/dt) in CHF rabbits was significantly decreased (p less than 0.001), taurine-treated CHF rabbits maintained the same values as control rabbits. Taurine content of the left ventricular tissue of the CHF rabbits was significantly increased (p less than 0.01). Administration of taurine and GES to control rabbits for 8 weeks affected neither the hemodynamics nor the taurine content of the heart. It was concluded that taurine slowed the rapid progression of heart failure and consequently prolonged life expectancy.
D000818:Animals; D001022:Aortic Valve Insufficiency / Q000150:complications; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D006439:Hemodynamics / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D011817:Rabbits; D013654:Taurine / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use*; D013997:Time Factors
D013654:Taurine; C009558:taurocyamine; D002118:Calcium