title: Ultrastructural appearances of preneoplastic liver nodules induced through sequential treatment in rats.
abstract: The ultrastructural appearances of preneoplastic liver nodules induced in male Wistar rats through sequential treatment with diethylnitrosamine (DENA) and 2-acetylaminofluorene (2-AAF) followed by partial hepatectomy were investigated. Although separately non-specific, the lesions reported represented altogether a fairly characteristic pattern consistent with previous observations in tumors and in preneoplastic nodules induced by long-term treatment with single carcinogens. Such data support the view that sequential treatment followed by partial hepatectomy is a reliable method to study early phenotypic changes in hepatocarcinogenesis. Such treatment is also advisable because it requires only a short period of latency in comparison to other in vivo screening tests of potential carcinogens.
mesh_terms: D015073:2-Acetylaminofluorene; D000818:Animals; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine; D006498:Hepatectomy; D008113:Liver Neoplasms / Q000139:chemically induced / Q000648:ultrastructure*; D008297:Male; D008722:Methods; D008854:Microscopy, Electron; D010641:Phenotype; D011230:Precancerous Conditions / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004052:Diethylnitrosamine; D015073:2-Acetylaminofluorene