title: Calmodulin in Zajdela hepatoma cell growth.
abstract: Calmodulin levels were measured in Zajdela hepatoma cells growing both in vivo and in culture, with respect to the distribution of the cells into G1 and S+G2 phases of the cell cycle and growth conditions. These levels, expressed on a per-microgram of protein basis, were significantly elevated at the G1-S boundary and maintained throughout the remainder of the cell cycle. This elevation of calmodulin took place independently of the culture conditions. Taken together with previous observations, these data suggest that a threshold concentration for calmodulin is required for progression through the cell cycle, DNA synthesis and cell division.
mesh_terms: D000818:Animals; D001769:Blood; D002147:Calmodulin / Q000378:metabolism*; D002453:Cell Cycle; D002478:Cells, Cultured; D007399:Interphase; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002147:Calmodulin