Evaluation of effect of host immunity on growth of androgen-dependent Shionogi carcinoma 115 in the mouse.
Experiments were carried out to examine the role of the host defence mechanism in the proliferation of androgen-dependent Shionogi carcinoma 115 in the DS mouse. Stimulation of tumor growth by dexamethasone was synergistic with androgen action. Enhanced host immunity caused by bacterial infection resulted in remarkable inhibition of tumor growth. Not only androgen but also the host defence mechanism is one of the major factors that determine overall growth rate of the androgen-dependent tumor in this strain of mice.
D000728:Androgens / Q000502:physiology*; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent / Q000276:immunology* / Q000473:pathology; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D003907:Dexamethasone