title: The changes in the intervertebral disc after chemonucleolysis demonstrated by magnetic resonance imaging.
abstract: Magnetic resonance imaging (MRI) of the spine produces images which reflect the chemical composition of the intervertebral disc. We have conducted a prospective study of the serial changes in the MRI appearance of the intervertebral disc after chemonucleolysis with the enzyme chymopapain. Fourteen patients were studied after single-level chemonucleolysis and the results compared with a control group of 17 discs in six patients who had diagnostic discography without enzyme insertion. A consistent pattern of gradual loss of signal from the nucleus pulposus culminating in complete loss of nuclear signal was seen in all cases after chemonucleolysis. Chymopapain therefore produced MRI changes analogous with premature gross disc degeneration. The rate at which this occurred varied; complete loss of signal took at least six weeks. Transitory minor end-plate changes were present in five patients, probably representing a mild chemical discitis. No similar changes were seen in the discography group.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002917:Chymopapain / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D007404:Intervertebral Disc Chemolysis; D007405:Intervertebral Disc Displacement / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011446:Prospective Studies; D012585:Sciatica / Q000209:etiology; D013997:Time Factors
chemical_list: D002917:Chymopapain