The effect of a corticosteroid on the absorption of 131I-albumin from rabbit knee joint.
The disappearance rate of 131I-albumin from the knee joint in six rabbits was measured before and after intraarticular injection of 7.5 mg triamcinolonhexacetonide (Lederspan). A significant decrease in the synovial permeability was demonstrated after injection of triamcinolonhexacetonide (average 64 percent). It is concluded that this demonstrates that corticosteroids have a direct effect on the synovial membrane, which may be an important mechanism whereby they exert their therapeutic effect upon joints.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D007596:Joints / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism*; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D012711:Serum Albumin, Radio-Iodinated; D014222:Triamcinolone Acetonide