title: Effect of indomethacin on the progesterone secretion of hysterectomized pseudopregnant rats.
abstract: The length of pseudopregnancy and the progesterone levels in rats pseudopregnant and hysterectomized on their 2nd day and injected daily with indomethacin (500 g/0.2 ml) from the 2nd to 10th day do not differ from those exhibited by oil treated rats. On the contrary, indomethacin treatment from 11th day on, results in both a lengthening of the diestrous phase and a delayed luteolysis. These findings point out to an extrauterine prostaglandin synthesis mechanism participating in the functional luteolysis in histerectomized pseudopregnant rats.
mesh_terms: D000818:Animals; D005260:Female; D007044:Hysterectomy; D007213:Indomethacin / Q000494:pharmacology*; D003341:Luteolysis; D011374:Progesterone / Q000378:metabolism*; D011555:Pseudopregnancy; D051381:Rats
chemical_list: D011374:Progesterone; D007213:Indomethacin