title: Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus.
abstract: The nucleotide sequence of the gene encoding the matrix (M) protein of the Beaudette C strain of Newcastle disease virus (NDV) has been determined from overlapping cDNA clones. Control sequences typical of paramyxovirus mRNA start and polyadenylation signals have been identified. Assuming that the M gene starts and finishes at these sequences, the M gene is 1241 nucleotides long and encodes one long open reading frame of 364 amino acids, corresponding to a polypeptide of molecular weight 39605, in good agreement with estimates from SDS gels. The M protein has an amino acid sequence that is both hydrophobic and highly basic. The NDV M protein has sequence homologies to the M proteins of Sendai, measles, canine distemper and respiratory syncytial viruses.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000378:metabolism; D005796:Genes; D005814:Genes, Viral; D009522:Newcastle disease virus / Q000235:genetics*; D013045:Species Specificity; D014763:Viral Matrix Proteins; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D014763:Viral Matrix Proteins; D014764:Viral Proteins; D004247:DNA