The effect of cholecystokinin, bombesin and calcitonin on food intake in virgin, lactating and postweaning female rats.
During lactation food intake increases greatly without an accompanying large increase in body weight; therefore, this physiological state is an excellent example of non-obese hyperphagia. In the present study, we found that cholecystokinin (CCK-8) decreased food intake in lactating and virgin female rats. However, female rats were more resistant to the effect of CCK on eating following weaning of the pups. Bombesin (BB) suppressed food intake in virgin female rats and in lactating rats during early and mid lactation. Rats were resistant to its satiating effect during late lactation and during the postweaning period. Calcitonin potently suppressed food intake in virgin, lactating and postweaning rats. The present findings suggest that CCK and bombesin decrease food intake more effectively in virgin female rats and during earlier phases of lactation than during late lactation or postweaning.
D000818:Animals; D001066:Appetite / Q000187:drug effects; D001839:Bombesin / Q000494:pharmacology*; D002116:Calcitonin / Q000494:pharmacology*; D002149:Energy Intake; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D007774:Lactation; D011247:Pregnancy; D051381:Rats; D012844:Sincalide / Q000494:pharmacology*; D014886:Weaning
D002116:Calcitonin; D012844:Sincalide; D001839:Bombesin