Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.
BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.
D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D004224:Diterpenes; D046934:Ginkgolides; D006168:Guinea Pigs; D007783:Lactones; D010936:Plant Extracts / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011433:Propranolol / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D013921:Thrombocytopenia / Q000139:chemically induced
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D011433:Propranolol; C045856:ginkgolide B; D011738:Pyrilamine