Magnetic resonance appearance of the kidneys in paroxysmal nocturnal hemoglobinuria.
A diagnosis of paroxysmal nocturnal hemoglobinuria may be suggested with magnetic resonance imaging, based on the massive renal cortical hemosiderosis that occurs in this disease. A diffuse bilateral depression of renal cortical signal intensity will be observed that is caused mainly by a shortening of the T2 relaxation time of renal cortical protons by the paramagnetic effect of the locally increased ferric ion concentration in the proximal convoluted tubule.
D000328:Adult; D006457:Hemoglobinuria, Paroxysmal / Q000473:pathology*; D006486:Hemosiderosis / Q000209:etiology; D006801:Humans; D007672:Kidney Cortex / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male