DSP-4 treatment accelerates kindling.
Norepinephrine depletion of the central nervous system by peripheral N-(2-chloroethyl)-N-ethyl bromobenzylamine administration accelerates the development of seizures kindled by repeated stimulation of the amygdala. These data, in conjunction with previous 6-hydroxydopamine data, demonstrate the robustness of this phenomenon and emphasize the importance of noradrenergic innervation originating from the locus ceruleus in the suppression of seizure development.
D000200:Action Potentials / Q000187:drug effects; D000679:Amygdala / Q000187:drug effects; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013687:Telencephalon / Q000187:drug effects* / Q000378:metabolism
D001596:Benzylamines; C012102:DSP 4; D009638:Norepinephrine