Prognostic implications of the motor symptoms of Parkinson's disease with respect to clinical, computertomographic and psychometric parameters.
Forty-four Parkinson patients (19 patients of the rigid-akinetic type, 13, of the rigid-akinetic-tremor type, and 12, of the tremor type) were included in a study in order to analyse correlations of the expression of the motor symptoms tremor, rigidity, akinesia, with other clinical parameters, computertomographic aspect of brain atrophy and psychometrically assessed cognitive parameters. Rigidity and akinesia are significantly positively correlated with the severity of motor dysability, stage of the disease, and brain atrophy, as is akinesia with a history of pharmacotoxic psychosis. Tremor is significantly negatively correlated with motor dysability, stage of the disease, and history of pharmacotoxic psychosis. Akinesia is correlated with visuomotor dysfunction (tested with Bender Gestalt Test) and rigidity with the depression score (Zung scale). The tremor type is favorable, the rigid-akinetic type unfavorable with respect to motor disability and psychosis.
D000328:Adult; D000368:Aged; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000473:pathology*; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D009127:Muscle Rigidity / Q000503:physiopathology; D010300:Parkinson Disease / Q000145:classification / Q000503:physiopathology*; D011379:Prognosis; D011594:Psychometrics; D014057:Tomography, X-Ray Computed; D014202:Tremor / Q000503:physiopathology