Effect of ethylene glycol on the phase transition kinetics of gluco- and galactocerebrosides.
The effect of different concentrations of ethylene glycol in water on the phase transition (metastable----stable state) of Gaucher's glucocerebroside, of bovine brain cerebroside type II (non hydroxy acyl chains only) and of N-palmitoylgalactocerebroside has been investigated. The phase transition and its kinetics were inferred from the thermograms at different heating and cooling rates and confirmed by FTIR spectra of the cerebrosides in the different states. The significance of the conformational differences of the glucose and of the galactose residues with respect to their solvation, and the subsequent effect on the intermolecular interactions and the phase transition is discussed.
D002152:Calorimetry, Differential Scanning; D002554:Cerebrosides; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000494:pharmacology*; D005699:Galactosylceramides; D005963:Glucosylceramides; D007700:Kinetics; D013055:Spectrophotometry, Infrared
D002554:Cerebrosides; D005026:Ethylene Glycols; D005699:Galactosylceramides; D005963:Glucosylceramides; D019855:Ethylene Glycol