Relationship of HLA protein display to activation of 2-5A synthetase in HBe antigen or anti-HBe positive chronic HBV infection.
In this study we have examined the density of HLA class I protein display on the hepatocytes of patients with HBe antigen (HBeAg) or anti-HBe (HBeAb) positive chronic hepatitis B virus (HBV) infection and related this to the level of interferon activation of these cells determined by measuring hepatic oligo 2-5A synthetase activity. In HBeAg positive patients the density of HLA class I (HLA-I) protein was not significantly increased above that found in uninfected liver, but levels of 2-5A synthetase were twice normal. In anti-HBe positive patients, HLA-I density was markedly increased in the presence of normal 2-5A synthetase activity. These data are consistent with type I (alpha or beta) interferon activation of the hepatocytes in HBeAg positive patients and type II (gamma) interferon activity in anti-HBe positive subjects.
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D002908:Chronic Disease; D006680:HLA Antigens / Q000032:analysis*; D006509:Hepatitis B / Q000201:enzymology / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000276:immunology; D011506:Proteins / Q000032:analysis*
D006680:HLA Antigens; D006510:Hepatitis B Antibodies; D006513:Hepatitis B e Antigens; D011506:Proteins; D015088:2',5'-Oligoadenylate Synthetase