Decreased lipopolysaccharide content and enhanced susceptibility of leptospiras to serum leptospiricidal action and phagocytosis after treatment with diphenylamine.
Growth of leptospiras in the presence of diphenylamine (DPA) caused a decrease in the content of leptospiral lipopolysaccharide (LPS). In association with this decrease of LPS, leptospiras became susceptible to anti-leptospiral action of normal rabbit serum (NRS), leptospiricidal action of antibody and complement, and killing by phagocytes. DPA-treated leptospiras were eliminated rapidly from the blood of infected mice and could not grow in the animals.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D001770:Blood Bactericidal Activity; D004159:Diphenylamine / Q000494:pharmacology*; D007921:Leptospira interrogans / Q000032:analysis / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000032:analysis*; D051379:Mice; D010587:Phagocytosis; D014895:Weil Disease / Q000276:immunology
D000814:Aniline Compounds; D008070:Lipopolysaccharides; D004159:Diphenylamine