title: [Effect of pyrrolidone-2 on the cerebral circulation].
abstract: The ability of cyclic GABA derivative--pyrrolidone-2--to increase markedly cerebral blood flow both normally and in conditions of cerebral blood supply disturbances produced by unilateral 20-min ligation of a common carotid artery has been demonstrated. When pyrrolidone-2 administration accompanied bicuculline infusion (0.1 mg/kg) it did not provoke significant changes in the blood flow. Besides, bicuculline markedly weakened pyrrolidone-2 ability to relax the isolated grafts of cerebral arteries.
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D004347:Drug Interactions; D011760:Pyrrolidinones / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011760:Pyrrolidinones; C028537:2-pyrrolidone; D001640:Bicuculline
vernacular_title: Vliianie pirrolidona-2 na mozgovoe krovoobrashchenie.