Effects of intraperitoneal carbon disulfide on sensory-evoked potentials of Fischer-344 rats.
Sensory-evoked potentials (EPs) were studied in male Fischer-344 rats to characterize the electrophysiologic concomitants of carbon disulfide (CS2) neurotoxicity. Behavioral measures also studied were forelimb and hindlimb grip strengths and performance of a conditioned avoidance response task. CS2 (172, 286, and 400 mg/kg) administered intraperitoneally five days per week for eleven weeks caused a decrease in grip strength, interfered with escape from shock, and disturbed visual and auditory EPs. Latency of the fifth but not the first component of the brainstem auditory-evoked response was prolonged, indicating an effect on central auditory tract conduction. Conduction velocity in the ventral caudal nerve and latencies of somatosensory EP components were unaffected.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002246:Carbon Disulfide / Q000008:administration & dosage / Q000633:toxicity*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002246:Carbon Disulfide