Induction of sperm abnormalities in mice by quercetin.
Sperm abnormalities in mice induced by IP injection of quercetin at total cumulative doses of 16, 32, 80, and 160 mg/kg b. wt. administered fractionally on 5 successive days were quantitated by assessing the percent of sperm with abnormal heads or tails. Five weeks after the final injection a maximum of 14.8% abnormal sperm were observed with a total quercetin dose of 80 mg/kg b. wt. compared to the spontaneous control of 0.98%. Concomittantly, a 32.1% reduction in testicular weight occurred compared to control mice which was coincident with a reduction in sperm count of 28%.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011794:Quercetin / Q000633:toxicity*; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*
D005419:Flavonoids; D011794:Quercetin