Effects of scopolamine on components of delayed response performance in the rat.
The effects of scopolamine and methyl scopolamine on working memory processes were investigated in a paired trial, go-no go delayed response procedure in which rats initiated their own trials. Drug effects were examined concurrently on performance at three delays--no, 0, and 2.5 sec. Scopolamine disrupted no-delay (discrimination) performance in a dose-related manner. Scopolamine also progressively reduced performance at 0-delay and 2.5 sec delay more than at no-delay, but only at the highest administered dose (0.5 mg/kg). Scopolamine affected sensitivity, but not response bias. Although both scopolamine and methyl scopolamine reduced the probability of trial initiation, only scopolamine disrupted accuracy of performance on the initiated trials.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D019832:N-Methylscopolamine; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology; D012153:Retention, Psychology / Q000187:drug effects; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology*; D012602:Scopolamine Derivatives / Q000494:pharmacology
D012602:Scopolamine Derivatives; D012601:Scopolamine; D019832:N-Methylscopolamine