Olfactory bulbectomy protects against pilocarpine-induced motor limbic seizures in rats.
Systemic injection of pilocarpine (380 mg/kg) results in the development of motor limbic seizures in rats. Olfactory bulbectomy performed 7 days prior to pilocarpine administration has a strong protective effect against the seizures. Neuropathological changes which normally occur in this seizure model do not develop in the brains of bulbectomized animals.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology; D007274:Injections, Intraperitoneal; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009046:Motor Neurons / Q000187:drug effects / Q000503:physiopathology; D009830:Olfactory Bulb / Q000503:physiopathology* / Q000601:surgery; D010862:Pilocarpine; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D010862:Pilocarpine