Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital.
Ornithine decarboxylase (ODC) activity and DNA synthesis were measured in the forestomach, urinary bladder and liver of rats given diet containing 2% butylated hydroxyanisole (BHA), 5% sodium saccharin (SS) or 0.05% phenobarbital (PB) for 21 weeks. ODC activity was not increased significantly in any of these organs in any of the groups, but the labeling index (LI) of the forestomach epithelium was increased by BHA and PB, and that of the urinary bladder epithelium by SS. PB did not increase the LI of the liver. These results do not indicate any relation between the effects of promoters, and the ODC activity or DNA synthesis in non-initiated target organs.
D000818:Animals; D002083:Butylated Hydroxyanisole / Q000633:toxicity*; D004247:DNA / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D010634:Phenobarbital / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012439:Saccharin / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects
D002083:Butylated Hydroxyanisole; D004247:DNA; D009955:Ornithine Decarboxylase; D012439:Saccharin; D010634:Phenobarbital