title: Osseointegration of titanium implants.
abstract: Forty-eight screws, six double cylindrical implants and six T-plates were inserted into the tibia or femur of 6 dogs. Two titanium screws were inserted into the proximal tibia of 5 patients to anchor a titanium mould. The implants were removed en bloc with adjacent bone tissue after 3 to 14 months. They were sectioned using a technique that allowed analysis of the intact tissue-to-metal specimens. Osseointegration, defined as a direct bone-to-implant contact without interposed soft tissue, was confirmed in all screw-shaped implants while the cylindres had only partial bone contact as did the T-plates. We conclude that osseointegrated implants may be applicable in joint reconstruction for arthrosis or rheumatoid arthritis.
mesh_terms: D000328:Adult; D000818:Animals; D001858:Bone Nails; D001860:Bone Plates; D001863:Bone Screws; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D019736:Prostheses and Implants; D013997:Time Factors; D014025:Titanium / Q000494:pharmacology*
chemical_list: D014025:Titanium