The pathogenesis of hyperlipoproteinaemia.
The hyperlipoproteinaemias are among the most commonly encountered metabolic derangements seen in clinical practice, and are important because of their frequent association with atherosclerotic vascular disease. Although their underlying biochemical defects are not yet completely elucidated, sufficient comprehension of normal lipoprotein metabolism has now been acquired to permit us to ascribe mechanisms to these clinical conditions as we know them. This article briefly summarises the plasma lipoprotein transport system and classifies the major primary lipoprotein disorders according to current understanding of the pathological changes responsible for their presentation.
D006801:Humans; D008072:Hyperlipoproteinemia Type I / Q000378:metabolism; D006938:Hyperlipoproteinemia Type II / Q000378:metabolism; D006952:Hyperlipoproteinemia Type III / Q000378:metabolism; D006954:Hyperlipoproteinemia Type V / Q000378:metabolism; D006951:Hyperlipoproteinemias / Q000145:classification / Q000209:etiology* / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D011973:Receptors, LDL