Corneal endothelial cell damage associated with intraocular gas tamponade during pars plana vitrectomy.
A prospective study was conducted of corneal endothelial damage associated with intraocular gas tamponade during pars plana vitrectomy performed in 44 patients. In addition to vitrectomy or combined vitrectomy-lensectomy, 25 patients (the gas-treated group) underwent intraocular gas tamponade, which was not performed in 19 patients (the control group). The central corneal endothelium was examined with a specular microscope preoperatively and 3 months postoperatively. Endothelial changes were quantitated by computerized morphometric analysis of individual cells. A total of 20 eyes were phakic after vitrectomy, 13 eyes in the gas-treated group and 7 eyes in the control group. The mean endothelial cell loss for the gas-treated group (1.9%) did not differ significantly from that for the control group (1.8%). Twenty-four eyes were aphakic after vitrectomy, 12 eyes in the gas-treated group and 12 eyes in the control group. The gas-treated group had a significantly greater cell loss (28.3%) than those in the control group (16.3%).
D000388:Air; D002452:Cell Count / Q000187:drug effects; D003315:Cornea / Q000187:drug effects / Q000473:pathology*; D048909:Diabetes Complications; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D005123:Eye; D005128:Eye Diseases / Q000601:surgery; D005459:Fluorides / Q000009:adverse effects*; D006470:Hemorrhage / Q000601:surgery; D006801:Humans; D007267:Injections; D007431:Intraoperative Complications; D013459:Sulfur Hexafluoride / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014821:Vitrectomy / Q000009:adverse effects*; D014822:Vitreous Body
D005459:Fluorides; D013459:Sulfur Hexafluoride