Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.
Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D003001:Cloning, Molecular; D005814:Genes, Viral; D051379:Mice; D008810:Mice, Inbred C57BL; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010954:Plasmacytoma / Q000235:genetics*; D051381:Rats; D013945:Thymoma / Q000235:genetics* / Q000382:microbiology; D013953:Thymus Neoplasms / Q000235:genetics* / Q000382:microbiology; D014158:Transcription, Genetic; D014178:Translocation, Genetic