title: The virgin, modified, human, umbilical vein graft: morphologic characteristics and mechanical properties.
abstract: The authors used macrophotography, endoscopy, roentgenography, light microscopy, and transmission and scanning electron microscopy to assess the morphologic characteristics of 37 virgin, human, umbilical vein grafts. The specimens showed deep longitudinal folds (22%) and multiple transverse folds of the intimal surface (27%), irregularity of wall thickness (41%) and intimal breakdown exposing thrombogenic layers of the vein wall to blood (19%). The mechanical properties also studied were dynamic compliance, Young's modulus, breaking strength and breaking strain. The mean dynamic compliance was 6.44 X 10(-4) mm Hg-1 (SD = 2.02 X 10(-4) mm Hg-1, i.e., 31%), which is in agreement with results of others. The specimens showed great variability in Young's modulus, breaking strength and breaking strain. The structural deficiencies and variable mechanical properties of human umbilical vein grafts require investigation to determine their effect on patency rates due to increased thrombogenicity and thus to establish whether there are potential hazards associated with their use.
mesh_terms: D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D003187:Compliance; D006801:Humans; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011475:Prosthesis Failure; D011673:Pulsatile Flow; D013314:Stress, Mechanical; D014471:Umbilical Veins