[Megakaryocytopoiesis studied in a mathematical model. 2. Regulation of cell differentiation following damage to part of the proliferating bone marrow pool by hydroxyurea].
Analysis of the earlier obtained data on the effect of hydroxyurea on megakaryocytopoiesis by a simulation model has shown that differentiation of proliferating precursors of the megakaryocytes depends on their amount in bone marrow; the time of their involvement in the proliferating pool increases if the number of proliferating cells decreases. Within 24 h after the treatment with hydroxyurea (900 mg/kg), the transit time for the mouse megakaryocytes is reduced by about 14 h due to acceleration of the latest developmental stages. A hypothesis is put forward which accounts for correlation between the duration of proliferative period and the volume and maturation time of megakaryocytes.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002452:Cell Count / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D006918:Hydroxyurea / Q000494:pharmacology*; D008433:Mathematics; D008533:Megakaryocytes / Q000187:drug effects*; D051379:Mice; D008954:Models, Biological; D013997:Time Factors
D006918:Hydroxyurea
Izuchenie megakariotsitopoéza s pomoshch'iu matematicheskoĭ modeli. 2. Reguliatsiia differentsirovki kletok posle porazheniia chasti proliferiruiushchego pula kostnogo mozga oksimochevinoĭ.