Biochemical changes in subacute mycotoxicosis induced by T-2 toxin in rats.
The intragastric administration to male Wistar rats of T-2 toxin at 1-1.3 mg/kg body weight for 7 days caused a sharp decrease in the liver activity of lysosomal enzymes: beta-galactosidase, beta-N-acetylglucosaminidase, alpha-mannosidase, cathepsins A, B, C and D and in the activity of enzymes of the 1st phase of metabolism of xenobiotics--aniline hydroxylase and carboxylesterase, as well as in the cytochrome P-450 level. At the same time, the subacute toxic effect of T-2 toxin was manifested in a significant increase in the activity of epoxide hydrolase and an enzyme of the 2nd phase of metabolism of xenobiotics--UDP-glucuronosyltransferase. A possible mechanism of the observed enzymological changes is discussed.
D000818:Animals; D005978:Glutathione / Q000378:metabolism; D008297:Male; D009145:Mushroom Poisoning / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000008:administration & dosage; D013270:Stomach; D013605:T-2 Toxin / Q000008:administration & dosage
D012717:Sesquiterpenes; D005978:Glutathione; D013605:T-2 Toxin