Lipemic and lipoproteinemic effects of natural and synthetic androgens in humans.
Testosterone cypionate administration in weight-trained subjects reduced serum high-density lipoprotein cholesterol (HDL-C) levels without affecting the total cholesterol (Total-C)/HDL-C ratio. Nandrolone decanoate administration also reduced HDL-C levels, but elevated the Total-C/HDL-C ratio. These findings could not be attributed to changes in exercise patterns, dietary intake, or alcohol consumption. It is concluded that the synthetic androgen employed in this study produced a worsening of potential lipid-related risk factors for ischemic heart disease and that exogenous testosterone has a much less pronounced effect on such risk factors.
D000328:Adult; D000728:Androgens / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077603:Nandrolone Decanoate; D012715:Sesame Oil / Q000008:administration & dosage; D013739:Testosterone / Q000008:administration & dosage; D014280:Triglycerides / Q000097:blood; D014891:Weight Lifting
D000728:Androgens; D008076:Cholesterol, HDL; D008074:Lipoproteins; D014280:Triglycerides; D013739:Testosterone; D009277:Nandrolone; D012715:Sesame Oil; D002784:Cholesterol; D000077603:Nandrolone Decanoate