Negative feedback inhibition of pancreatic exocrine secretion in humans.
The evidence is quite solid that a feedback inhibition system of the pancreatic exocrine secretion exists in a number of animal species. Whether or not such a regulatory system is operative in man remains controversial. Studies in normal human subjects which have been interpreted as evidence that such a regulatory system is not present in man suffer from serious flaws in experimental design, such as the inability to completely divert pancreatic enzymes (chymotrypsin, elastase) as important principles in this control mechanism. Studies in both normal human subjects and patients with chronic pancreatitis will be reviewed.
D002766:Cholecystokinin / Q000097:blood; D004386:Duodenum / Q000201:enzymology; D006706:Homeostasis; D006801:Humans; D010182:Pancreatic Diseases / Q000503:physiopathology; D010189:Pancreatic Juice / Q000201:enzymology / Q000378:metabolism*; D012016:Reference Values; D014357:Trypsin / Q000378:metabolism*
D002766:Cholecystokinin; D014357:Trypsin