Blood dapsone levels in leprosy patients treated with acedapsone.
The metabolism of the repository drug acedapsone (DADDS,4,4'-diacetyldiaminodiphenyl sulfone) was studied in 15 individuals receiving 225 mg of DADDS, intramuscularly for a period of 75 days. Plasma levels of DDS were determined on the 2nd, 7th, 15th, 30th, 60th and 75th day after administration of the drug by spectrophoto-fluorometric technique. The mean peak levels of DDS (85.36 ng/ml) were noticed on 7th day followed by a gradual decrease in DDS concentration. The mean half-life level (44.53 ng/ml) of DDS were observed around the 15th day. The mean DDS level for the entire period of observation after one dose was 41.95 ng/ml. On the 75th day, the DDS level reached the minimum value of 14.76 ng/ml which was still about 5 times more than the minimal inhibitory concentration (MIC) level of DDS against M. leprae (3 ng/ml). The results are discussed.
D000072:Acedapsone / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D000328:Adult; D000818:Animals; D003622:Dapsone / Q000031:analogs & derivatives* / Q000097:blood* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007918:Leprosy / Q000097:blood* / Q000188:drug therapy; D051379:Mice; D013997:Time Factors
D000072:Acedapsone; D003622:Dapsone