[Effect of amphotericin B on the sterol composition of Kluyveromyces bulgaricus and Kluyveromyces lactis].
The degree of sensitivity of the yeasts Kluyveromyces bulgaricus and K. lactis to amphotericin B is linked to a difference in the sterol composition of their membranes. No direct proportionality was found between sensitivity and the quantity of sterols present. At sublethal doses, amphotericin B perturbed sterol synthesis, resulting in ergosterol precursor accumulation. An ergosterol pathway is proposed for Kluyveromyces.
D000666:Amphotericin B / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D007716:Kluyveromyces / Q000187:drug effects / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D004718:Saccharomycetales / Q000378:metabolism*; D013045:Species Specificity; D013261:Sterols / Q000302:isolation & purification / Q000378:metabolism*
D008563:Membrane Lipids; D013261:Sterols; D000666:Amphotericin B
Action de l'amphotéricine B sur la composition en stérols de Kluyveromyces bulgaricus et Kluyveromyces lactis.