Cellular location of 'liver-specific' antigen F.
Three mouse monoclonal antibodies against Type 1 murine 'liver-specific' antigen F and one rat monoclonal antibody against human antigen F were produced. These monoclonals recognize antigenic determinants common to Type 1 and Type 2 mouse and human antigen F. By immunolabelling with beta-galactosidase, antigen F could be demonstrated in the cytoplasm of hepatocytes, tubules of the kidney, and perikarya of neurons of the central nervous system. F antigens isolated from liver, kidney, and brain all have molecular weights of around 40,000.
D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D007519:Isoantigens / Q000032:analysis* / Q000276:immunology / Q000502:physiology; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D007519:Isoantigens; C030497:liver specific F antigen