In vitro responses of bronchial spirals and parenchymal strips from healthy and heartworm-infected dogs.
Bronchial spirals and pulmonary parenchymal strips from control (noninfected) and Dirofilaria immitis-infected dogs were tested for isometric contractile response to histamine and carbamylcholine. Responses of bronchial spirals from control dogs and from D immitis-positive groups did not differ in responses to histamine or carbamylcholine. Parenchymal strips from D immitis-positive dogs showed greater response to histamine than did those from controls; responses to carbamylcholine did not differ.
D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000503:physiopathology; D002217:Carbachol / Q000494:pharmacology; D004184:Dirofilariasis / Q000503:physiopathology / Q000662:veterinary*; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D006632:Histamine / Q000494:pharmacology; D007537:Isometric Contraction / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000503:physiopathology; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology*
D006632:Histamine; D002217:Carbachol