Early sucrose-induced retinal vascular lesions in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY).
Retinal capillary basement membrane damage was demonstrated over a relatively short time period (two to three months) by feeding a diet containing high amounts of sucrose to spontaneously hypertensive rats (SHR) and their normotensive controls, Wistar Kyoto rats (WKY). Similar changes did not occur in SHR and WKY on a high starch diet. The early damage to the capillaries consisted of thickening of capillary basement membranes, loss of homogeneity, and inclusions containing debris. Previous studies on sucrose-induced eye lesions have reported chronic pathological changes only after prolonged periods of heavy sucrose ingestion, usually exceeding one year. Accordingly, the temporally foreshortened experimental pathogenesis offered by the SHR/WKY model allowed us to examine early changes in sucrose-induced vascular eye lesions.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D002196:Capillaries / Q000648:ultrastructure; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012164:Retinal Diseases / Q000209:etiology; D012171:Retinal Vessels / Q000648:ultrastructure*; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D013395:Sucrose; D013213:Starch