Influence of subinhibitory concentrations of clindamycin on opsonophagocytosis of Staphylococcus aureus, a protein-A-dependent process.
Incubation in subinhibitory concentrations of clindamycin enhanced the uptake of protein A-rich Staphylococcus aureus strains by polymorphonuclear leukocytes. This enhancement of uptake appeared to be due, in part, to a reduction in the amount of protein A at the bacterial cell surface by clindamycin.
D002981:Clindamycin / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D013205:Staphylococcal Protein A / Q000037:antagonists & inhibitors*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000276:immunology
D013205:Staphylococcal Protein A; D002981:Clindamycin