Effect of distal enterectomy on cholesterol and bile salt levels in the rat.
The effect of 50% or 80% distal enteroctomy on cholesterol and bile salt levels in male Wistar rats have been investigated. Short time measurements showed that serum cholesterol levels were maximal after 20 days from 50% intestinal resection and after 10 days from 80% intestinal resection. This increase was maintained in 50% resected rats 1 and 5 months after operation, whilts in 80% resected group the values became normal. Portal blood and bile cholesterol levels remain almost normal except 5 months after 50% intestinal resection. Bile salt concentration and bile salt output in the bile decrease after 1 and 5 months from 50% intestinal resection and after 1 month from 80% intestinal resection. These results together with data of fecal loss of bile salts indicate that in 50% resected rats new steady states have been reached, with low levels of bile salts in the bile. One month after 80% resection the fecal loss of bile salts was so high that the conversion of cholesterol into bile salts was increased. After 5 months from 80% resection values in serum and bile were almost normal suggesting either an increase in extrahepatic cholesterol synthesis or a partial prevention of fecal loss that can be explained by the observed caecal enlargement.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D007421:Intestine, Small / Q000601:surgery*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001647:Bile Acids and Salts; D002784:Cholesterol