Relationships between the levels of binding to DNA and the carcinogenic potencies in rat nasal mucosa for three alkylating agents.
Three direct-acting carcinogens, beta-propiolactone (BPL), methylmethane sulfonate (MMS), and dimethylcarbamyl chloride (DMCC), were evaluated for their carcinogenic potencies in the nasal mucosa of rats and for their abilities to bind in vivo to rat nasal mucosal DNA. The relative carcinogenic potencies of BPL and MMS corresponded well with their overall levels of binding to nasal mucosal DNA. DMCC, however, the most potent carcinogen of the three compounds, produced the lowest level of binding to nasal mucosal DNA. These results indicate that the DNA adducts formed by DMCC in rat nasal mucosa DNA are more readily expressed as cancer than those formed by BPL or MMS.
D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D002219:Carbamates / Q000378:metabolism / Q000633:toxicity*; D002273:Carcinogens; D004247:DNA / Q000378:metabolism*; D007783:Lactones / Q000633:toxicity*; D008297:Male; D008741:Methyl Methanesulfonate / Q000378:metabolism / Q000633:toxicity*; D009297:Nasal Mucosa / Q000378:metabolism*; D009669:Nose Neoplasms / Q000139:chemically induced*; D011420:Propiolactone / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000477:Alkylating Agents; D002219:Carbamates; D002273:Carcinogens; D007783:Lactones; C001036:dimethylcarbamyl chloride; D011420:Propiolactone; D004247:DNA; D008741:Methyl Methanesulfonate