Ketoconazole in experimental vaginal candidosis in rats.
Rats in pseudoestrous were treated subcutaneously with ketoconazole at 25 mg/kg twice a day. In both uninfected and infected rats ketoconazole inhibited the cornification of the vaginal epithelium. Thus, ketoconazole, in addition to having an antifungal effect, may aid in the removal of candida by inhibiting the epithelial conditions suitable for hyphal invasion.
D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000473:pathology; D004967:Estrogens / Q000378:metabolism; D005260:Female; D007654:Ketoconazole / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014621:Vagina / Q000187:drug effects
D004967:Estrogens; D007654:Ketoconazole