Acute thrombogenicity of a compliant polyurethane urea graft compared with polytetrafluoroethylene: an experimental study in sheep.
The acute thrombogenicity of a new polyurethane urea graft has been compared with polytetrafluoroethylene (PTFE) grafts using labelled homologous platelets in the carotid arteries of sheep in a low-flow model. There was no difference in patency. Thrombus weight and thrombus free surface were the same in both types of graft after 4 h. The accumulation of homologous 32P platelets was measured at the 2 anastomoses and at a midgraft position. At no point was there any statistically significant difference between the 2 grafts, but the activity was always somewhat higher in the polyurethane grafts. Although more compliant, in this study polyurethane urea grafts behaved much like PTFE ones.
D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis / Q000295:instrumentation*; D003187:Compliance; D010974:Platelet Aggregation; D011138:Polytetrafluoroethylene; D011140:Polyurethanes; D012756:Sheep; D013927:Thrombosis / Q000209:etiology*
D001672:Biocompatible Materials; D011140:Polyurethanes; D011138:Polytetrafluoroethylene