Carcinogenesis by N2-[gamma-L(+)-glutamyl]-4-carboxyphenylhydrazine of Agaricus bisporus in mice.
N2-[gamma-L(+)-glutamyl]-4-carboxyphenylhydrazine (GCPH), an ingredient of the cultivated mushroom of commerce Agaricus bisporus (AB), was administered as 52 weekly intragastric instillations of 1.4 mg/g body weight to randomly bred Swiss mice. In comparison with the untreated controls, the subcutaneous tumor incidences rose from 0 to 26% in the males, while in the females the corresponding tumor incidences were 6 and 2%, respectively. Histopathologically the tumors were fibrosarcomas, fibromas and myxomas. The study is part of a long - range objective to reveal the biological effect of N-N-bond-containing hydrazines and related chemicals of AB.
D000818:Animals; D001487:Basidiomycota; D005260:Female; D005350:Fibroma / Q000139:chemically induced; D005354:Fibrosarcoma / Q000139:chemically induced; D005971:Glutamates / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009232:Myxoma / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010936:Plant Extracts / Q000633:toxicity*; D012737:Sex Factors
D005971:Glutamates; D010936:Plant Extracts; C018830:anthglutin