The effect of carbohydrate overfeeding on blood pressure in the pregnant, spontaneously hypertensive rat.
Carbohydrate overfeeding increases blood pressure in the spontaneously hypertensive rat. This study was undertaken to determine if dietary carbohydrate supplementation throughout pregnancy could prevent the normal fall in blood pressure during the last week of gestation. Systolic blood pressure in the control-fed pregnant rats decreased progressively during the last week and was in the normotensive range by term; that of the carbohydrate-supplemented, pregnant rats remained high and was not significantly lower than that of nonpregnant rats at any time. At term, daily urinary norepinephrine excretion, but not epinephrine excretion, by the carbohydrate-supplemented pregnant rats was twice that of control-fed nonpregnant and pregnant rats, suggesting that the hypertension was due to increased sympathetic nervous activity. Carbohydrate supplementation had no effect on blood pressure or catecholamine excretion in pregnant, normotensive Wistar-Kyoto rats. There were no differences in litter size or mean birth weight between diet treatment groups of either strain.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004195:Disease Models, Animal; D004231:Diuresis; D004326:Drinking; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY
D004040:Dietary Carbohydrates