title: Syn/anti isomerization of cefuroxime by ultraviolet light.
abstract: Cefuroxime, like all the oximino cephalosporins on the market, has the methoxyimino group in the syn (Z) configuration. By U.V. light irradiation of cefuroxime, a syn/anti isomerization occurs until equilibration of the two isomers is reached. Measurement of the 1H-N.M.R. chemical shift differences of the two isomers allows the assignment of methoxyimine stereochemistry.
mesh_terms: D002444:Cefuroxime / Q000032:analysis / Q000528:radiation effects*; D002511:Cephalosporins / Q000528:radiation effects*; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D010777:Photochemistry; D013237:Stereoisomerism; D014466:Ultraviolet Rays
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime