Antitumour activity of 1-naphthol against L1210 leukaemia in vivo and Ehrlich ascites tumour cells in vivo and in vitro.
1-Naphthol inhibited ascitic fluid formation in mice infected intraperitoneally with either L1210 leukaemia or Ehrlich ascites tumour cells (EATC). A significant increase in life span was observed in EATC but not in L1210 bearing mice dosed with 1-naphthol (50-60 mg/kg). 1-Naphthol caused a concentration-dependent toxicity to EATC in vitro.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009284:Naphthols / Q000494:pharmacology / Q000627:therapeutic use*
D009284:Naphthols; C029350:1-naphthol