Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome.
We describe a patient with idiopathic hypereosinophilic syndrome (IHS) having PAF-acether activity corresponding to 4 X 10(-11) M/10(6) eosinophils as determined by standard aggregation curves prepared with purified PAF-acether. These data suggest that the increased PAF-acether content in patients with IHS may play a role in the development of thrombotic phenomena through platelet activation.
D000328:Adult; D004802:Eosinophilia / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D010972:Platelet Activating Factor / Q000378:metabolism*; D013577:Syndrome; D013927:Thrombosis / Q000209:etiology
D010972:Platelet Activating Factor