[Autoimmunity to collagen, experimental arthritis and rheumatic disease].
Auto-immunity to type II collagen is now recognised as a good experimental model of arthritis. The possibility of a post-immunization treatment with collagen to suppress or abrogate the arthritic response is particularly interesting in the therapeutical trends suggested by such a possibility. In human pathology, if the pathogenic role of anti-native collagen type II auto-antibodies is well demonstrated in relapsing polychondritis, in the contrary, this hypothesis does not seem relevant to rheumatoid arthritis. In this disease, the role of the auto-immunity to native collagen appears secondary.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D003094:Collagen / Q000276:immunology* / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D010007:Osteochondritis / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D003094:Collagen
Auto-immunité anti-collagène, arthrite expérimentale et maladie rhumatoïde.