title: Postclotting fates of thrombin.
abstract: During the clotting of blood, prothrombin is virtually all converted to thrombin. By contrast, Factor X is not. Large quantities of thrombin are inhibited by plasma and platelet AT III (heparin cofactor I), by heparin cofactor II, and by fibrin. Lesser quantities function in various reactions in which thrombin specificity is modified for greater effectiveness. Some thrombin binds to platelets as well as blood vessel endothelial cells, but the latter facts were not included herein.
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation; D005170:Factor X / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D015844:Heparin Cofactor II; D006801:Humans; D011516:Prothrombin / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D015844:Heparin Cofactor II; D000990:Antithrombin III; D011516:Prothrombin; D005170:Factor X; D013917:Thrombin