title: Irrigating solutions used in arthroscopy and their effect on articular cartilage. An in vivo study.
abstract: The effect of arthroscopic irrigating solutions on articular cartilage was determined by the use of an animal model. Rabbit knee joints were irrigated continuously for two hours with either normal saline, Ringer's lactate, or sterile water. Subsequently, the rate of incorporation of 35SO4 by articular cartilage was used to measure the effect of the irrigants on chondrocyte metabolism. In addition, the irrigated groups were compared to an unirrigated control group. There was no significant difference in 35SO4 incorporation between the groups. This suggested that none of the irrigating solutions used in this study adversely affected articular cartilage function. On the basis of these findings, it appears that normal saline, Ringer's lactate, and sterile water can be safely used as irrigating solutions during most arthroscopic procedures.
mesh_terms: D000818:Animals; D001182:Arthroscopy; D002358:Cartilage, Articular / Q000187:drug effects*; D007552:Isotonic Solutions; D011509:Proteoglycans / Q000096:biosynthesis; D011817:Rabbits; D000077325:Ringer's Lactate; D012965:Sodium Chloride; D013431:Sulfates; D013462:Sulfur Radioisotopes; D007507:Therapeutic Irrigation; D013997:Time Factors
chemical_list: D007552:Isotonic Solutions; D011509:Proteoglycans; D000077325:Ringer's Lactate; D013431:Sulfates; D013462:Sulfur Radioisotopes; D012965:Sodium Chloride