Partial muscle carnitine palmitoyltransferase-A deficiency. Rhabdomyolysis associated with transiently decreased muscle carnitine content after ibuprofen therapy.
After initiation of ibuprofen therapy, a 45-year-old woman developed muscle weakness and tenderness with rhabdomyolysis, culminating in respiratory failure. A muscle biopsy specimen showed a vacuolar myopathy, and markedly decreased muscle carnitine content and carnitine palmitoyltransferase activity. Following recovery, muscle carnitine content was normal but carnitine palmitoyltransferase activity was still abnormally low. The ratio of palmitoyl-coenzyme A plus carnitine to palmitoylcarnitine oxidation by muscle mitochondria isolated from the patient was markedly decreased. We conclude that transiently decreased muscle carnitine content interacted with partial deficiency of carnitine palmitoyltransferase-A to produce rhabdomyolysis and respiratory failure and that ibuprofen may have precipitated the clinical event.
D000217:Acyltransferases / Q000172:deficiency*; D002331:Carnitine / Q000172:deficiency*; D002334:Carnitine O-Palmitoyltransferase / Q000172:deficiency*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D050356:Lipid Metabolism; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism; D009132:Muscles / Q000201:enzymology* / Q000378:metabolism; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000209:etiology* / Q000378:metabolism
D005227:Fatty Acids; D000217:Acyltransferases; D002334:Carnitine O-Palmitoyltransferase; D002331:Carnitine; D007052:Ibuprofen