Serum progesterone levels following vaginal administration of progesterone during the luteal phase.
We measured serum progesterone (P) levels after administration of 400 mg P vaginal suppositories to women during the luteal phase of the menstrual cycle. Blood samples were obtained before suppository insertion and at five intervals up to 8 hours after insertion. On the first day of treatment with P suppositories, there was a substantial elevation in serum P above baseline after insertion. However, on subsequent days of administration a smaller increment in serum P was observed. In 4 women studied on days 1 and 8 of the same treatment cycle in the luteal phase, a smaller rise in serum P following suppository administration on day 8, compared with day 1, was found. Overall, a highly significant negative correlation between change in serum P from baseline and duration of vaginal suppository treatment was found. This observation does not appear to be related to the achievement of a pharmacokinetic steady state. Possible mechanisms for this observation are discussed.
D000282:Administration, Intravaginal; D000328:Adult; D005260:Female; D006801:Humans; D008183:Luteal Phase; D011293:Premenstrual Syndrome / Q000188:drug therapy; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D011374:Progesterone