Temporal profile of tissue levels of dopamine and its metabolites, HVA and DOPAC following focal cerebral ischaemia in anaesthetized primates.
Occlusion of the middle cerebral artery produced ischaemia and consequent changes in basal ganglia in the primate model of stroke within 0.5 h. Dopamine content was decreased in the right basal ganglia from 0.5 h up to 12 h after occlusion. Homovanillic acid content of the right basal ganglia increased initially at 0.5 h but, was decreased at 12 h. The DOPAC content was increased at 2 h after occlusion in the right basal ganglia, but was decreased significantly at 12 h. In the substantia nigra, there was a significant reduction in the DA content in the right side at 12 h. Minimal changes were observed in the DOPAC and HVA content in the right substantia nigra at 2 h and 4 h, respectively. At other time periods there was no significant change in the content of HVA and DOPAC in substantia nigra.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000098:blood supply / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D008255:Macaca radiata; D008297:Male; D013378:Substantia Nigra / Q000378:metabolism; D013702:Temporal Lobe / Q000098:blood supply / Q000378:metabolism; D014018:Tissue Distribution
D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid