title: Basal N-nitrosoproline formation and excretion in the ferret.
abstract: Quantitative balance studies indicated that ferrets (Mustela putorius furo) on purified diets excreted approximately four times more N-nitrosoproline than they ingested. This basal N-nitrosoproline excretion was not dependent on dietary nitrate intake, as high levels of dietary [15N]nitrate did not result in the incorporation of 15N into the excreted N-nitrosoproline. This indicates that there are at least two sources of endogenous N-nitrosoproline formation, one linked to dietary nitrate and one independent of dietary nitrate. The latter may result from an intermediate in the endogenous synthesis of nitrate.
mesh_terms: D000818:Animals; D004032:Diet; D005289:Ferrets; D008297:Male; D009566:Nitrates / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism* / Q000652:urine
chemical_list: D009566:Nitrates; D009602:Nitrosamines; C010259:nitrosoproline