Stimulation of exocrine pancreatic secretion by met-enkephalin.
The effect of met-enkephalin on pure exocrine pancreatic secretion was studied in five subjects with external transduodenal drainage of the main pancreatic duct carried out after biliary tract surgery. Intravenous infusion of a low dose of met-enkephalin (0.15 micrograms/kg/h) during submaximal pancreatic stimulation with secretin (25 ng/kg/h) and cerulein (10 ng/kg/h) significantly increased pancreatic outputs. Bicarbonate secretion increased 50% above control values, a more marked effect than the increase in enzyme secretion (maximal rise averaged 22%). The effect of the peptide was rapid, persisted for the duration of met-enkephalin infusion and then tended gradually to diminish.
D001639:Bicarbonates / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D001639:Bicarbonates; D011506:Proteins; D004744:Enkephalin, Methionine