On the interrelations of immune and mediator receptors of mice lymphocytes.
It was shown that the blockade of M-cholinereceptors, of B-lymphocytes in the spleen of mice of the BALB/c line immune to sheep erythrocytes, by parasympatholytics 3H-Quinuclidinyl benzilate, etc., markedly inhibits the rosette-formation with the specific antigen. The blockade of M-cholinereceptors of B-lymphocytes in the mice spleen of the given line by the anticholinereceptor rabbit serum (with removed Forsmann antibodies) induces a similar result. The specific antigen fixation on B-lymphocytes of mice immunized by egg albumin is suppressed by preliminary blockade of M-cholinereceptors by the above mentioned parasympatholytics. The number of free cholinereceptors on the surface of B-lymphocytes of mice spleen immunized with egg albumin, was reduced after the specific antigen was joined. The blockade of beta-adrenoreceptors of mice spleen evokes a similar effect but in a lesser degree. The problem of interrelation of immune and mediator lymphocyte receptors is discussed in relation with the mechanisms of nervous regulation of immune and allergic reactions.
D000818:Animals; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011812:Quinuclidines / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate / Q000494:pharmacology*; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology*
D011812:Quinuclidines; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate