Clinical experience with low dosage of propionohydroxamic acid (PHA) in infected renal stones.
The use of drugs inhibiting bacterial urease represents an interesting improvement in preventive treatment of renal infected stones. The low dose (120 mg/day) for one week followed by 60 mg/day of propionohydroxamic acid (PHA) has shown excellent anti-urease activity. The nearly normal absence of side effects also allows long-term administration.
D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000032:analysis / Q000150:complications*; D008274:Magnesium / Q000032:analysis; D017616:Magnesium Compounds; D010710:Phosphates / Q000032:analysis; D000069877:Struvite; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology
D006877:Hydroxamic Acids; D017616:Magnesium Compounds; D010710:Phosphates; C036612:propionohydroxamic acid; D000069877:Struvite; D008274:Magnesium