Potent mitogenic activity of 4-acetylaminofluorene to the rat liver.
Administration of 4-acetylaminofluorene (4AAF) to rats by oral gavage (1000 mg/kg) produces a wave of S-phase activity in the liver 36 h later, followed by a wave of mitoses at 48 h. These events were monitored by autoradiography of isolated hepatocytes and by histopathology, respectively. DNA-labelling was shown to occur following both in vivo and in vitro radiolabelling. The level of S-phases observed approached that reported following partial hepatectomy. These effects were not accompanied by unscheduled DNA synthesis (UDS) nor was any frank histopathological damage to the liver evident. 2-Acetylaminofluorene (2AAF) elicited a very weak S-phase response at a dose level of 50 mg/kg, but gave marked UDS between 12 and 48 h.
D015073:2-Acetylaminofluorene / Q000494:pharmacology* / Q000031:analogs & derivatives; D000818:Animals; D004247:DNA / Q000235:genetics; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007399:Interphase / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats
D004247:DNA; D015073:2-Acetylaminofluorene; C028676:4-acetylaminofluorene