The ability of uremic serum to induce neutrophil chemotaxis in relation to hemodialysis.
The ability of serum to attract normal neutrophil granulocytes was investigated in 11 uremic patients before and after hemodialysis using a modified assay system for granulocyte migration under agarose. The chemotactic responses towards serum from the uremic patients were significantly decreased (p less than 0.01) prior to hemodialysis compared to control serum from a healthy individual. Hemodialysis acutely normalized the depressed chemotactic responses. It is concluded that hemodialysis improves the ability of uremic serum to attract neutrophils, and it is suggested that this improvement might be due to removal of granulocyte inhibitory factors from the sera.
D002634:Chemotaxis, Leukocyte; D005260:Female; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood / Q000276:immunology* / Q000628:therapy