Alterations in the lipids and prostaglandins in mouse spleen following the ingestion of menhaden oil.
Two groups of male mice were fed for 2 weeks with a semisynthetic diet supplemented with either 10% hydrogenated coconut oil or 10% menhaden oil. The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1 alpha and prostaglandin E2 by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D005395:Fish Oils / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010743:Phospholipids / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D011506:Proteins / Q000378:metabolism; D013154:Spleen / Q000378:metabolism*
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D010743:Phospholipids; D011453:Prostaglandins; D011506:Proteins; C033266:Menhaden oil; D002784:Cholesterol