title: Cholinergic blockade effects on spatial integration versus cue discrimination performance.
abstract: A within-subjects investigation was conducted to determine the effects of central versus peripheral cholinergic blockade in animals tested either on a spatial integration task in which the possibility of rule learning was also available or on a visual discrimination task in which the daily location of food was marked by a distinctive visual stimulus pattern. All testing was conducted on the Maier three-table apparatus. It was found that the only effect of the peripheral cholinergic blockade on the performance of either task group was to produce a decrease in exploratory behavior. In contrast, central cholinergic blockade markedly impaired spatial integration performance; however, it did not impair the ability of animals in rule learning or visual discrimination learning. It was also found that central cholinergic blockade impaired the animal's tendency to enter all tables before reentering a given table during the exploratory phase of the daily session. This finding was interpreted as reflecting an impairment of working memory for spatial information, rather than a general impairment in working memory, and this interpretation was applied to the explanation of the deficit in the spatial integration performance.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001286:Atropine Derivatives / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D009420:Nervous System / Q000187:drug effects; D009424:Nervous System Physiological Phenomena; D051381:Rats; D013028:Space Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D001286:Atropine Derivatives; D001285:Atropine; C006649:methylatropine