[Effect of pharmacological substances on the altered permeability of the hemato-encephalic barrier for 14C-tyrosine due to ethanol].
It has been demonstrated that membrane-stabilizing agents, chlorpromazine and alpha-tocopherol, have no effect on the increased blood-brain barrier permeability for 14C-tyrosine, induced by a single injection of ethanol at a dose of 2 and 4 g/kg. Dopaminergic antagonist haloperidol prevented the increase of blood-brain barrier permeability induced by a single injection of 2 g/kg of ethanol and diminished the elevated barrier permeability caused by chronic 10-day alcoholization of animals, including abstinent ones. The role of membrane and neuromediator components in the mechanisms regulating blood-brain barrier functions is discussed.
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002250:Carbon Radioisotopes; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology
D002250:Carbon Radioisotopes; D014810:Vitamin E; D000431:Ethanol; D014443:Tyrosine; D006220:Haloperidol; D002746:Chlorpromazine
Vliianie nekotorykh farmakologicheskikh veshchestv na izmenenie pronitsaemosti gematoéntsefalicheskogo bar'era dlia 14C-tirozina, vyzvannoe étanolom.