Local anaesthetics. IV--Synthesis and activity of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles.
Synthesis is described of eleven new 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles (I). Their hydrochlorides were screened for local anaesthetic activity on frogs by the sciatic plexus method and the activity compared with that of procaine.
D000081:Acetamides / Q000138:chemical synthesis / Q000494:pharmacology; D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001001:Anura; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D011343:Procaine / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000081:Acetamides; D000779:Anesthetics, Local; D013844:Thiazoles; D011343:Procaine