Adjuvant effects of calmodulin antagonists to 5-fluorouracil on tumor cell proliferation and the mechanisms.
The adjuvant effect of calmodulin antagonists (W-5 and W-7) to 5-fluorouracil (5-FU) was studied by using two human cultured cell lines derived from ovarian adenocarcinoma. Enhancement of the uptake of 5-[6-3H]fluorouracil ([3H]FU) by cancer cells was observed only when calmodulin antagonists were added in the presence of [3H]FU. Similarly, the adjuvant effect by W-5 or W-7 on cancer cell proliferation was also observed only when calmodulin antagonists were added in the presence of 5-FU.
D000230:Adenocarcinoma / Q000473:pathology; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D005472:Fluorouracil / Q000633:toxicity*; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology; D013449:Sulfonamides / Q000633:toxicity*
D002147:Calmodulin; D013449:Sulfonamides; C017967:W 7; C034700:N-(6-aminohexyl)-1-naphthalenesulfonamide; D005472:Fluorouracil