153Sm radiotherapeutic bone agents.
Samarium-153 is a radionuclide which can be produced in high yield by neutron irradiation and which has nuclear properties that make it attractive for use as a radiotherapeutic agent. Several phosphonate complexes of 153Sm were synthesized and characterized by electrophoresis and HPLC. A procedure based on cation exchange chromatography was developed for measuring complex yields. The complexes could be produced in yields greater than 99%, were anionic, and most exhibited a single HPLC peak.
D000085:Acetates; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008024:Ligands; D011868:Radioisotopes / Q000627:therapeutic use*; D012493:Samarium / Q000627:therapeutic use*
D000085:Acetates; D008024:Ligands; D011868:Radioisotopes; D012493:Samarium