title: Distribution of epidermal growth factor binding sites in the adult rat adrenal gland by light microscope autoradiography.
abstract: The distribution of epidermal growth factor (EGF) receptors was studied in the adrenal gland using light microscope autoradiography which was carried out 2 min after intravenous (iv) injection of [125I]EGF into adult rat. At the light microscope level, the labelling was found over the cells of the capsule and adrenal medullary chromaffin cells. No specific labelling of the steroid-secreting cells was observed. Control experiments indicated that the autoradiography reaction was due to specific interaction of [125I]EGF with its receptor. These results clearly indicate that EGF receptors are present in the majority of the adrenal medulla cells. They suggest that EGF may exert a physiological role in the regulation of rat adrenal medulla.
mesh_terms: D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007457:Iodine Radioisotopes; D066246:ErbB Receptors