Penetration kinetics of liposomal hydrocortisone in human skin.
The applicability of liposomal hydrocortisone (HC) as a selective drug delivery system for cutaneous administration of glucocorticoids has been studied. With the liposomal form, a considerably better concentration-time profile was obtained in the individual layers of human skin than with the corresponding HC ointment. The pronounced carrier ability of liposomes for HC holds promise for an increase in its therapeutic efficacy, thus reducing unwanted side effects of the topical glucocorticoid therapy.
D000287:Administration, Topical; D002463:Cell Membrane Permeability / Q000187:drug effects; D004817:Epidermis / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism* / Q000627:therapeutic use; D066298:In Vitro Techniques; D007700:Kinetics; D008081:Liposomes / Q000008:administration & dosage* / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012869:Skin Absorption
D008081:Liposomes; D006854:Hydrocortisone