title: Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition.
abstract: Adecypenol, which exhibits potent inhibitory activity against calf intestinal adenosine deaminase (EC 3.5.4.4), was isolated from the cultured broth of Streptomyces sp. OM-3223. Adecypenol was classified as a semi-tight binding inhibitor. The Ki value against calf intestinal adenosine deaminase was 4.7 X 10(-9) M. No acute toxicity of adecypenol was observed at 100 mg/kg in mice. Adecypenol exhibited no antimicrobial activity against various bacteria and fungi at the concentration of 1.0 mg/ml.
mesh_terms: D058892:Adenosine Deaminase Inhibitors; D003517:Cyclopentanes / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007700:Kinetics; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D011687:Purines / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism
chemical_list: D058892:Adenosine Deaminase Inhibitors; D003517:Cyclopentanes; D011687:Purines; C048275:adecypenol; D009700:Nucleoside Deaminases