Trial of Russell's Viper Venoid. I. Immunization of monkeys with venoid. Burma, DMR Working Group on Russell's Viper Venoid.
Refined Russell's Viper Venoid was prepared by the mild and step-wise formalinization of pooled first four fractions obtained by Sephadex G-50 fractionation of Russell's viper venom. This preparation was found to be potent and immunogenic with minimum undesirable side effects. Satisfactory rise of circulating antitoxin levels was seen in monkeys immunized with the venoid and this rise persisted for 24 weeks. The immunized monkeys withstood intramuscular challenge with 2 mg/kg of the crude venom two weeks after a course of venoid injection.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D007114:Immunization; D008253:Macaca mulatta; D014121:Toxoids / Q000276:immunology*; D014757:Viper Venoms / Q000276:immunology*
D000906:Antibodies; D014121:Toxoids; D014757:Viper Venoms; C050899:viper venoid