Tetrazole analogs of amino acids as constituents of modifiers of carboxypeptidase A catalysis.
The action of substrate analogs containing the tetrazolyl group instead of the C-terminal carboxy group on the peptidase activity of carboxypeptidase A is studied. The analogs compete with the substrate for the secondary binding site thus showing activation phenomena.
D000596:Amino Acids / Q000494:pharmacology*; D001665:Binding Sites; D002268:Carboxypeptidases / Q000378:metabolism*; D043422:Carboxypeptidases A; D002384:Catalysis; D004789:Enzyme Activation; D007700:Kinetics; D013777:Tetrazoles / Q000494:pharmacology
D000596:Amino Acids; D013777:Tetrazoles; D002268:Carboxypeptidases; D043422:Carboxypeptidases A