Effect of alternating pressure on thrombin-stimulated platelets.
The effect of alternating pressure on several basic physiological processes of thrombin-stimulated platelets, e.g. shape changes, release of adenine nucleotides and activation of arachidonic platelet system was studied. It is assumed that redistribution of Ca2+ ions within platelets plays an essential role in the mechanism of alternating pressure effect. The data obtained emphasize the importance of the problems related to the action of alternating blood pressure on platelets during their circulation in cardiovascular system.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D001794:Blood Pressure; D002118:Calcium / Q000378:metabolism; D066298:In Vitro Techniques; D008315:Malondialdehyde / Q000096:biosynthesis; D011817:Rabbits; D013917:Thrombin / Q000378:metabolism / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000378:metabolism
D008315:Malondialdehyde; D013928:Thromboxane A2; D000255:Adenosine Triphosphate; D013917:Thrombin; D002118:Calcium