title: 3,5-Diamino-1,2,6-thiadiazine 1,1-dioxide derivatives: synthesis and antiparasitic activity.
abstract: The synthesis of new 3,5-diamino-1,2,6-thiadiazine 1,1-dioxide derivatives is described and their structures discussed on the basis of 1H and 13C-N.M.R. data. The antiparasitic activity of these and related compounds was evaluated. The bacterial mutagenicity of the parent compound (I) was studied.
mesh_terms: D000563:Amebicides / Q000138:chemical synthesis; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis; D000962:Antimalarials / Q000138:chemical synthesis; D000994:Antitrichomonal Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D009153:Mutagens; D010271:Parasites / Q000187:drug effects*; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013843:Thiazines / Q000138:chemical synthesis*
chemical_list: D000563:Amebicides; D000935:Antifungal Agents; D000962:Antimalarials; D000994:Antitrichomonal Agents; D009153:Mutagens; D013829:Thiadiazines; D013843:Thiazines