Increased response to peroxisomal proliferators in starved rats.
The induction of liver peroxisomal beta-oxidation activities by bezafibrate or Wy 14,643 was 2-4-fold higher in starved rats than in fed animals. The increased response to peroxisomal proliferators in starved rats was independent of the mode of administration of the proliferator, given either orally or by intraperitoneal injection. Inhibitors of carnitine acyltransferase I could prevent the induction of peroxisomal activities in starved rats but not in fed animals. In contrast to fasted rats, the induction of liver peroxisomal activities in streptozotocin-diabetic rats was not susceptible to bezafibrate. The higher sensitivity to peroxisomal proliferators under conditions of starvation may allow for the detection of xenobiotic peroxisomal proliferators of low proliferative potency.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001629:Bezafibrate / Q000494:pharmacology*; D004746:Enoyl-CoA Hydratase / Q000378:metabolism*; D006836:Hydro-Lyases / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010171:Palmitoyl Coenzyme A / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation
D000214:Acyl Coenzyme A; D000924:Anticholesteremic Agents; D011743:Pyrimidines; D010171:Palmitoyl Coenzyme A; C006253:pirinixic acid; D006836:Hydro-Lyases; D004746:Enoyl-CoA Hydratase; D001629:Bezafibrate