[Ultrastructure of the blood lymphoid cells and the dynamics of cellular immunity indices in chronic lympholeukemia patients during immunocorrection with T-activin].
Fourteen patients with chronic lymphoid leukemia who received treatment with T-activin given in courses (800-1100 micrograms) were examined for ultrastructure of blood lymphoid cells and the time-course of changes in humoral immunity. The patients had not received chemotherapy or hormonal treatment before. During the treatment with T-activin, no chemotherapeutic remedies were administered. After immunocorrection chemotherapy and hormones were prescribed when necessary. In the patients, the number of E-RFC (T cells) rose, whereas the number of B cells carrying surface immunoglobulins and the number of Em-RFC decreased. At the same time the prolonged use of T-activin brought about an increase in the number of B cells containing heavy chains of immunoglobulins M, G and A in the cytoplasm, while no considerable rise of serum immunoglobulins M, G and A was detected. Ultrastructural studies made during the use T-activin demonstrated a double rise in the number of lymphoplasmocytes, and in that of wide-plasma lymphocytes. The latter ones measuring 10 to 12 microns showed hypertrophy of Golgi's complexes and of the endoplasmic network. It is suggested that administration of T-activin for the B cell version of chronic lympholeukemia produces the differentiation of B cells, accompanied by the appearance in the cytoplasm of heavy chains of immunoglobulins M, G and A, which is supported by immunological and morphological analysis.
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000276:immunology / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010455:Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D013949:Thymus Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Ul'trastruktura limfoidnykh kletok krovi i dinamika pokazateleĭ dletochnogo immuniteta u bol'nykh khronicheskim limfoleĭkozom v protsesse immunokorrektsii T-aktivinom.