Separation of the tremorous and muscular rigidity components of the ethanol withdrawal syndrome in the rat.
The alcohol withdrawal syndrome consists of a kinetic tremor, the tremorous component, and a peculiar abnormality of tone called asterixis, the muscular rigidity component. The severity of the ethanol withdrawal syndrome in the rat is generally assessed by the severity of the tremors. 3-Hydroxybutyrate suppresses the tremorous component but not the muscular rigidity component of the ethanol withdrawal syndrome, thus effectively differentiating the two components in the rat.
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects*; D006885:Hydroxybutyrates / Q000627:therapeutic use; D008297:Male; D009127:Muscle Rigidity / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology*
D006885:Hydroxybutyrates; D000431:Ethanol; D020155:3-Hydroxybutyric Acid