title: Isoflurane: its use to induce hypotension in neurosurgical patients.
abstract: The use of isoflurane to induce arterial hypotension was studied in 40 adults undergoing neurosurgery. In 70% of patients, isoflurane, up to 2.0% (inspired), decreased mean arterial pressure (MAP) to the desired level for surgery; for the remainder, a higher concentration (3.0-4.0%) was required. Tachycardia, which could be slowed by labetalol, occurred in 13 patients (32%); the incidence was significantly higher in those who had not received an opiate either as premedication or intra-operatively. No post-operative complications attributable to hypotension were seen. It is concluded that isoflurane is a safe and effective agent for the induction of hypotension in neurosurgical operations.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000758:Anesthesia; D001794:Blood Pressure / Q000187:drug effects; D003399:Craniotomy; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007016:Hypophysectomy; D007023:Hypotension, Controlled; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures
chemical_list: D007530:Isoflurane