Platelet aggregation and the pharmacology of local anaesthetics.
Local anaesthetics significantly inhibit platelet aggregation and prolong the lag period of collagen-induced aggregation, but only at toxic concentrations. This appears to be due to stabilization of the platelet membrane. While the phenomenon is not clinically significant, the platelet may serve as a readily available, easily harvested, renewable human cellular model for studying the pharmacology of local anaesthetics.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects*
D000779:Anesthetics, Local; D000244:Adenosine Diphosphate; D003094:Collagen