The delay in polyhalogenated aromatic hydrocarbon-induced porphyria: the effect of diet preparation.
Porphyria development in female Wistar rats has been followed by dosing the animals with hexachlorobenzene (HCB) either dissolved in corn oil or as a solid mixed with the diet. It was found that the corn oil preparation resulted in much faster uptake of HCB into the liver, and much faster accumulation of liver porphyrins. Diet preparation is thus shown to be a major factor in determining whether the development of porphyria is associated with the delay phenomenon. Evidence is also presented suggesting that the neurological symptoms of porphyria are not caused by high porphyrin levels.
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight; D056486:Chemical and Drug Induced Liver Injury; D002722:Chlorobenzenes / Q000633:toxicity*; D002851:Chromatography, High Pressure Liquid; D003314:Corn Oil; D005260:Female; D005502:Food; D006581:Hexachlorobenzene / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007408:Intestinal Absorption; D009929:Organ Size; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D002722:Chlorobenzenes; D011166:Porphyrins; D006581:Hexachlorobenzene; D003314:Corn Oil