title: Fluorine-NMR studies of chimpanzee hemoglobin.
abstract: It has been demonstrated that 4-fluorophenylalanine, a known inhibitor of protein synthesis, becomes incorporated into hemoglobin when present in the diet of a chimpanzee. 19F-NMR spectra of various forms of this protein show well-resolved lines, each line presumably corresponding to a unique phenylalanine/fluorophenylalanine position of the primary sequence. Fluorine chemical shifts and, by implication, tertiary structures vary with the oxidation state and ligand.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005461:Fluorine; D006454:Hemoglobins; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010108:Oxyhemoglobins / Q000302:isolation & purification; D002679:Pan troglodytes; D010649:Phenylalanine; D010135:p-Fluorophenylalanine
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D005461:Fluorine; D010649:Phenylalanine; D010135:p-Fluorophenylalanine