title: Effect of cadmium on essential metal concentrations in testis, liver and kidney of five inbred strains of mice.
abstract: To compare the organ injuries by cadmium administration among inbred strains of mice, CdCl2 was injected subcutaneously into C3H/He, BALB/c, DBA/2, CBA/J and C57BL/6 strains at a dose of 30 mumol/kg body weight, and the changes of 6 essential metal [sodium (Na), magnesium (Mg), potassium (K), calcium (Ca), iron (Fe) and zinc (Zn)] concentrations were determined at 6, 24 and 48 h. Testicular Cd concentrations at 6 h in DBA/2 and CBA/J were significantly higher than those in the other 3 strains. Marked alterations in testicular metal concentrations (increases in Na, Ca and Fe and decreases in K and Mg) were observed in the 2 strains. At 48 h, hepatic Cd concentration in BALB/c was decreased from the higher level at 24 h and an abrupt increase in renal Cd concentration was detected. Changes in hepatic essential metal concentrations at 48 h in BALB/c were in the same direction as those in the testis of DBA/2 and CBA/J. As a whole, C3H/He, BALB/c and C57BL/6 strains showed more remarkable alterations in hepatic essential metal concentrations, except Zn level, than DBA/2 and CBA/J which showed larger increases in Zn concentration (probably due to larger metallothionein induction). It was suggested from the data that C3H/He, BALB/c and C57BL/6 were strains sensitive to the hepatotoxicity of Cd and that DBA/2 and CBA/J were susceptible to the testicular toxicity of Cd.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008670:Metals / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013045:Species Specificity; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D008670:Metals; D002104:Cadmium