title: Effects of aging on the formation of ester forms of riboflavin in the rat lens.
abstract: We studied the effects of aging on the formation of ester forms of riboflavin in the lens of rats. The formation was highest in newborn and 2-week-old rats; a sharp decrease was noted at one month, thereafter it continued to decrease gradually reaching a plateau at 3 months. In general, esterification of riboflavin was higher in female than male rats. We found that a decrease in the esterification of riboflavin with increasing age is a characteristic change in the rat lens. This finding may help to clarify the pathogenesis of senescent change in the lens.
mesh_terms: D000375:Aging; D000818:Animals; D004951:Esterification; D005260:Female; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000096:biosynthesis
chemical_list: D012256:Riboflavin