Synthesis of some 1-acetylindoline-5-sulphonylamino acid derivatives and studies of their antimicrobial activities.
The synthesis of a series of 1-acetylindoline-5-sulphonylamino acids and some of the corresponding methyl esters and hydrazides (II-XXIII) is described. Coupling of 1-acetylindoline-5-sulphonylamino acids with amino acid methyl ester hydrochlorides in THF-Et3N medium, using the dicyclohexylcarbodiimide method gave the desired 1-acetylindoline-5-sulphonyldipeptide methyl esters (XXIV-XXVIII). Most of the synthetic 1-acetylindoline-5-sulphonylamino acid and dipeptide derivatives (II-XXVII) were found to possess various antimicrobial activities against a number of microorganisms.
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology
D000596:Amino Acids; D000890:Anti-Infective Agents; D004151:Dipeptides; D007211:Indoles; D013450:Sulfones