Synthesis and pharmacological properties of decahydro-5H-pyrido [1',2'; 5,1]imidazo[3,4-a]-beta-carbolines.
Cyclic aminals (1-4) including a form of decahydro-5H-pyrido[1', 2'; 5, 1] imidazo [3, 4-a]-beta-carboline were obtained by treating erythro 1-(2'-piperidyl)-1,2,3,4-tetrahydro-beta-carboline with aldehydes. The central action of compounds 1-4 has been investigated using behavioral tests in mice and rats. The most active aminal was a phenyl derivative 4, which showed an anticonvulsive activity in the maximal electroshock seizure test. The overall activity of compound 4 was less potent than that of phenytoin.
D000818:Animals; D000927:Anticonvulsants; D002243:Carbolines / Q000138:chemical synthesis / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D002243:Carbolines; D010672:Phenytoin