Is there regeneration of cholinergic axons through traumatic scar tissue in adult mammalian brain?
After a 2-mm coronal incision was made in the cerebral cortex of adult rats, cholinergic axonal reaction and growth were assessed by acetylcholinesterase histochemistry between 3 and 56 days postinjury. Early axonal reaction in the proximal stumps consisted of hypertrophy and terminal swellings, many with extended processes. Axonal fiber density rostral to the lesion remained constant throughout the observation period; caudally it was reduced but increased with time. Cholinergic fibers appeared to cross the lesion, although definitive tracing of individual fibers was not possible.
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001369:Axons / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000201:enzymology / Q000254:growth & development*; D002921:Cicatrix / Q000503:physiopathology*; D006651:Histocytochemistry; D009416:Nerve Regeneration; D051381:Rats; D011919:Rats, Inbred Strains
D000110:Acetylcholinesterase