Immunoreactive somatomedin B (RIA-B) in the circulation of healthy adults and patients with endocrine disorders.
The serum and cerebrospinal fluid (CSF) levels of immunoreactive somatomedin B (RIA-B) were examined throughout life in healthy adult humans. A significant decline in serum RIA-B was observed in subjects over 60 years of age. No significant diurnal, daily, or monthly serum variation was observed in healthy subjects aged 20-60 years. However, women taking oral contraceptives had elevated RIA-B values. No significant decline in CSF RIA-B was observed in subjects over 60 years of age. A significantly lower level of RIA-B in CSF was observed in subjects sampled at 20.00 h compared to subjects sampled in the morning. A significant decline in serum RIA-B was observed in patients with hypopituitarism and diabetes mellitus and a significant elevation of serum RIA-B levels was observed in patients with hyperthyroidism. CSF RIA-B was significantly elevated in patients with Cushing's syndrome.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002940:Circadian Rhythm; D003276:Contraceptives, Oral / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004700:Endocrine System Diseases / Q000097:blood* / Q000134:cerebrospinal fluid / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values; D013002:Somatomedins / Q000097:blood* / Q000134:cerebrospinal fluid / Q000652:urine
D003276:Contraceptives, Oral; D013002:Somatomedins; C016756:somatomedin B