Morphological study of the combined effect of purpurin derivatives and light on transplantable rat bladder tumors.
Purpurin derivatives, a group of synthetic photosensitizers, were tested for their photodynamic activity against transplantable N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced urothelial tumors growing in male Fischer 344 rats. Histological examination of tumors in animals treated with the purpurin derivatives and red light (greater than 590 nm, 360 joules/cm2) revealed tumor cell necrosis 24 h after completion of therapy. Control tumors showed no histological change. Purpurins have a major absorption peak in the red region (greater than 650 nm) of the visible spectrum, a region with good tissue penetration, and purpurins can be synthesized with a high degree of purity. This study demonstrates the potential of purpurin derivatives as photosensitizers for photodynamic cancer therapy.
D000818:Animals; D000880:Anthraquinones; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D037102:Lectins; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D011838:Radiation-Sensitizing Agents; D051381:Rats; D013329:Structure-Activity Relationship; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology
D000880:Anthraquinones; D037102:Lectins; D011838:Radiation-Sensitizing Agents; C511975:purpurin anthraquinone