Gastrointestinal absorption of sulpiride in rat.
A two-compartment model could be used to describe the elimination of sulpiride from plasma after intravenous administration of 25 and 50 mg/kg doses to rat. The absolute bioavailability after oral administration was only about 15% which was also the level after intraduodenal administration. Higher bioavailabilities were found after mesenteric venous and intravenous administration (sham-operated rat) due to a decrease in the beta-value (elimination rate constant). The low bioavailability of sulpiride following oral administration was concluded to result, not from metabolism in the liver, but from reduced absorption by the gastrointestinal tract.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D007700:Kinetics; D008297:Male; D008642:Mesenteric Veins; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride / Q000097:blood / Q000378:metabolism*
D013469:Sulpiride