title: Developmental neurotoxicology of in utero exposure to industrial solvents in experimental animals.
abstract: In summary, relatively few solvents have been examined for developmental neurotoxicology. Although most of the studies have not been replicated, the majority of the solvents tested have produced significant differences from controls. Many used inhalation, which is often the most likely route of occupational or environmental exposure. The majority have extended the exposure for much of gestation of rats. The extensive usage of solvents and the proportion of those tested which have produced positive effects (although admittedly some not at environmentally-relevant exposure concentrations), make a strong case for additional testing of industrial solvents for developmental neurotoxicology.
mesh_terms: D000818:Animals; D000440:Butanols / Q000633:toxicity; D002246:Carbon Disulfide / Q000633:toxicity; D002617:Chemical Industry; D002725:Chloroform / Q000633:toxicity; D005260:Female; D005557:Formaldehyde / Q000633:toxicity; D008742:Methyl n-Butyl Ketone / Q000633:toxicity; D008752:Methylene Chloride / Q000633:toxicity; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011433:Propranolol / Q000633:toxicity; D012997:Solvents / Q000633:toxicity*; D013750:Tetrachloroethylene / Q000633:toxicity; D014240:Trichloroethanes / Q000633:toxicity; D020002:tert-Butyl Alcohol
chemical_list: D000440:Butanols; D012997:Solvents; D014240:Trichloroethanes; C024566:1,1,1-trichloroethane; D005557:Formaldehyde; D008752:Methylene Chloride; D008742:Methyl n-Butyl Ketone; D002725:Chloroform; D011433:Propranolol; D020002:tert-Butyl Alcohol; D002246:Carbon Disulfide; D013750:Tetrachloroethylene