[Activation of peroxisomal acyl-CoA oxidase and lipid peroxidation in the rat myocardium as affected by prolonged administration of ethanol].
The influence of chronic alcoholic intoxication on the activity of peroxisomal acyl-CoA oxidase and antioxidative defensive enzymes (catalase, glutathione reductase, glutathione-S-transferase, superoxide dismutase, glucose-6-phosphate dehydrogenase) was studied in the rat myocardium. The parameters of lipid peroxidation in cardiomyocytes (the level of spontaneous chemiluminescence, accumulation of thiobarbituric acid-reactive material), as well as reduced glutathione content were also examined. The data obtained suggest that ethanol-induced activation of lipid peroxidation in the myocardium may be due to the elevation of hydrogen peroxide-generating activity of peroxisomes.
D042962:Acyl-CoA Oxidase; D000437:Alcoholism / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase
Aktivatsiia peroksisomal'noĭ atsil-KoA-oksidazy i perekisnogo okisleniia lipidov v miokarde krys pri dlitel'nom vvedenii étanola.