[Thrombin neutralization by antithrombin III depending upon the intensity of thrombin-formation in experimental and clinical surgical interventions].
Low rate of thrombinogenesis, its gradual and prolonged development in animal circulation after small-scale surgical operations was accompanied by a compensatory increase in the activity of antithrombin III. After surgical operations of lung in children thrombinoformation at the high rate led to distinct short-term consumption and to decrease in activity of the inhibitor during the operation period and within 2-3 days after the operation simultaneously with activation of enzymatic and nonenzymatic fibrinolysis. At the same time, any postoperational thrombotic complications were not observed in the children.
D000818:Animals; D000990:Antithrombin III / Q000032:analysis*; D001780:Blood Coagulation Tests; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008099:Liver / Q000601:surgery; D008297:Male; D011013:Pneumonectomy; D011183:Postoperative Complications; D051381:Rats; D013917:Thrombin / Q000032:analysis / Q000096:biosynthesis*; D013923:Thromboembolism / Q000097:blood* / Q000209:etiology
D000990:Antithrombin III; D013917:Thrombin
Neĭtralizatsiia trombina antitrombinom III v zavisimosti ot intensivnosti trombinoobrazovaniia pri éksperimental'nykh i klinicheskikh khirurgicheskikh vmeshatel'stvakh.