title: Peri- and postnatal, teratology and reproductive studies of a low molecular weight heparin in rats.
abstract: The low molecular weight heparin (OP/LMWH) used in these studies elicited no evidence of teratogenicity when administered by subcutaneous route during the period of organogenesis to pregnant rats at doses up to 10 mg/kg/d. In reproductive studies there were no effects on conception or pregnancy in males or females rats at dosages up to 10 mg/kg/d (by s.c. route). In these studies the doses were used that in chronic toxicity had shown unremarkable toxic effects on animals. In teratologic and in peri- and postnatal experiments unfractionated heparin at doses of 1 and 10 mg/kg/d by s.c. route was used for comparison.
mesh_terms: D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects; D006493:Heparin / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013723:Teratogens; D014599:Uterus / Q000187:drug effects
chemical_list: D013723:Teratogens; D006493:Heparin