[Inhibition by diphenols of the induction of micronuclei by gamma-radiation].
A study was made of the influence of diphenols (for instance, resorcinol, hydroquinone, and pyrocatechin) on gamma-radiation induction of micronuclei (1.5 Gy). The position of the diphenol molecule hydroxyl group (the isomeric effect) was shown to influence their antimutagenic activity. This antimutagenic effect of the diphenols is associated with their ability to produce semiquinone and quinone forms which are peculiar for the process of oxidation of pyrocatechin (ortho-) and hydroquinone (para-) as opposed to resorcinol (meta-position of the hydroxyl group).
D000818:Animals; D001854:Bone Marrow Cells; D002588:Cesium Radioisotopes; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D066298:In Vitro Techniques; D051379:Mice; D009154:Mutation; D010636:Phenols / Q000494:pharmacology*; D011831:Radiation Genetics
D002588:Cesium Radioisotopes; D010636:Phenols
Ingibirovanie difenolami induktsii mikroiader gamma-izlucheniem.