Association between HLA and Sjögren's syndrome in Japanese patients.
Japanese patients with primary Sjögren's syndrome (SS), patients with SS and rheumatoid arthritis (SS-RA), and patients with SS and connective tissue disease without RA (nonrheumatoid connective tissue disease [SS-CTD]) were typed for HLA antigens. Patients with primary SS and those with SS-RA had higher frequencies of DRw53 than did those who had SS-CTD; however, the group with SS-CTD showed a negative correlation with DRw52. These data indicate that Japanese and white patients with SS have different HLA specificities, and that genetic factors involved in the development of SS-CTD might be different from those in primary SS and SS-RA.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification*; D006801:Humans; D008297:Male; D012859:Sjogren's Syndrome / Q000276:immunology*
D006680:HLA Antigens