Increased glutathione (GSH) content in livers of control and carbon tetrachloride poisoned rats treated with the anticalmodulin drug trifluoperazine (TFP).
TFP administration to rats (50 mg/kg, ip) 6 hr after olive oil or CCl4 (1 mg/kg, ip as a 20% olive oil solution) significantly increases the GSH content in liver at 24 hr. The role of GSH increases in the late preventive effects against CCl4 hepatotoxicity is discussed. A link between the calcium/calmodulin (CaM) system and the GSH status in liver is postulated.
D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014268:Trifluoperazine / Q000627:therapeutic use*
D002147:Calmodulin; D014268:Trifluoperazine; D005978:Glutathione