title: A multiplicative correction factor for tissue heterogeneities.
abstract: A new multiplicative correction factor for tissue heterogeneities based on an exact expression for homogeneous non-unit-density media is proposed. O'Connor's density scaling theorem is invoked to evaluate the medium-specific tissue-maximum ratios used in the exact formulation. Monte Carlo calculations were performed at energies ranging from 60Co to 15 MV to test the technique for single- and multiple-slab geometries as well as for the clinical benchmark problem described recently by Orton et al consisting of a six-field lung plan. Within the level of statistical uncertainty (less than 2%) in the Monte Carlo calculations, the new correction factor agrees with the calculated data for single slabs of non-unit-density material. For the multiply layered geometries, the correction factor accurately represents the data beyond the build-up region at any interface, but is less reliable close to a boundary. For high energies, however, it is more accurate in the build-up region than other commonly used correction techniques such as the ratio-of-TMR or Batho methods. For all energies considered, the new correction factor agrees with the data measured by Orton et al to within 1.5%. It is more accurate than other correction factors considered by Orton et al at high energies, and is competitive with the Batho and equivalent TAR methods at low energies.
mesh_terms: D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D006801:Humans; D009010:Monte Carlo Method; D011827:Radiation; D011878:Radiotherapy / Q000379:methods*
chemical_list: D003037:Cobalt Radioisotopes