[Effect of bromocriptine on 3H-dopamine uptake in hypothalamic synaptosomes of intact and adrenalectomized rats].
Intensity of 3H-dopamine uptake in hypothalamic synaptosomes was similar both in intact rats and in the animals which received a single administration of bromocriptine at a dose of 5 mg/kg within 4 hrs. Within 4 days after the drug administration incorporation of the label was increased 1.22-fold and 1.28-fold in intact and adrenalectomized rats, respectively. Alterations in dopamine uptake in hypothalamic synaptosomes caused by bromocriptine appear to be one of dopaminergic-dependent effects of the drug in the animal brain structures.
D000315:Adrenalectomy; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*
D001971:Bromocriptine; D004298:Dopamine
Vliianie bromkriptina na zakhvat 3H-dofamina sinaptosomami gipotalamusa intaktnykh i adrenaléktomirovannykh krys.