[Mechanisms of the origination of hypersegmented (hyperdiploid) neutrophils in rats as affected by cyclophosphamide].
Feulgen cytophotometry has revealed tetraploid DNA content in some hypersegmented mature granulocytes in rat peripheral blood after two weeks of daily injections of cyclophosphamide (20 mg/kg of body weight). In bone marrow of rats which were given the preparation for 7 days myeloblasts, promyelocytes and myelocytes are blocked in G2 phase of the mitotic cycle. About 50% of metamyelocytes, bands and segmented granulocytes are also tetraploid. Thus cyclophosphamide has induced tetraploid hypersegmented neutrophils in rats as a result of maturation of G2 blocked proliferative pool granulocytes.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D003592:Cytophotometry; D004247:DNA / Q000187:drug effects; D004171:Diploidy; D006098:Granulocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003520:Cyclophosphamide; D004247:DNA
O mekhanizmakh obrazovaniia gipersegmentirovannykh (giperdiploidnykh) neĭtrofilov u krys pod vliianiem tsiklofosfamida.