HLA antigens in diabetics with calcified shoulder periarthritis (CSP).
The distribution frequencies of HLA-A and B antigens was determined in 94 maturity onset diabetics (40 with CSP and 54 without CSP), as well as in 400 unrelated age- and sex-matched Greek controls. The standard NIH technique was used for tissue typing. There was an increased prevalence of the antigen B27 only in diabetics with CSP (35%) when compared either to the controls (6.8%) or to diabetics without CSP (9.2%). The calculated p-corrected values were Pc = 0.00027 and Pc greater than 0.005 respectively. These findings indicate that the MHC in man may control the genetic susceptibility of a subgroup of insulin-independent diabetics to develop CSP.
D002114:Calcinosis / Q000150:complications* / Q000235:genetics / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D010489:Periarthritis / Q000150:complications* / Q000276:immunology; D012782:Shoulder
D006680:HLA Antigens