title: Can the cost savings of eliminating urine microscopy in biochemically negative urines be extended to the pediatric population?
abstract: The authors determined the value of performing urine microscopy on biochemically negative urine specimens in a pediatric population. Four reactions of the Chemstrip-9TM (Biodynamics, Inc., Indianapolis, IN) were used as biochemical indicators, namely, protein, occult blood, leukocyte esterase, and nitrite. Out of 1,016 urine specimens thus studied, 310 were true positive. Eleven specimens reacted biochemically in the absence of significant microscopic findings (false positive), 668 specimens were negative by the Chemstrip-9 and were either negative microscopically or had less than five white blood cells (WBCs) per high power field (HPF) and were considered true negatives. Twenty-seven specimens had negative biochemical indicators, in spite of positive microscopy; of these specimens, only seven had more than ten WBCs per HPF, 17 had five to ten WBCs per HPF, and three had five to ten red blood cells per HPF. The sensitivity of the four parameters for predicting significant microscopy of urinary sediment is 91% and the specificity is 98%. The predictive value of a negative result is 96.1%, and that of a positive result is 96.5%. The authors therefore conclude that urine microscopy is unnecessary in biochemically negative urine specimens from pediatric patients who are asymptomatic for urinary tract disease.
mesh_terms: D002648:Child; D003363:Cost Control; D004950:Esterases / Q000652:urine; D006417:Hematuria / Q000175:diagnosis; D006801:Humans; D008853:Microscopy / Q000191:economics*; D009573:Nitrites / Q000652:urine; D011507:Proteinuria / Q000175:diagnosis; D011934:Reagent Strips; D014556:Urine / Q000032:analysis*
chemical_list: D009573:Nitrites; D011934:Reagent Strips; D004950:Esterases