Metabolism of 11-deoxycortisol by a Bacillus species.
Microbial transformation by a Bacillus species was employed for the preparation of potentially important derivatives of 11-deoxycortisol. Each microbial metabolite was characterised by the application of various spectroscopic methods. The five metabolites of 11-deoxycortisol were characterised as 4-androstene-3,17-dione (2), 14-hydroxy-4-androstene-3,17-dione (3), 14,17 alpha,21-trihydroxy-4-pregnene-3,20-dione (4), 6 beta,17 alpha,21-trihydroxy-4-pregnene-3,20-dione (5) and 15 alpha,17 alpha,21-trihydroxy-4-pregnene-3,20-dione (6). The availability of the metabolites enabled complete elucidation of their [13C]NMR spectra.
D015065:17-Hydroxycorticosteroids / Q000378:metabolism*; D001407:Bacillus / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D003350:Cortodoxone / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D015065:17-Hydroxycorticosteroids; D003350:Cortodoxone