Constriction of the fetal ductus arteriosus by progesterone.
Progesterone substitution in the rat during pregnancy days 17-21 or administration 6 h before spontaneous delivery constricted the fetal ductus arteriosus. The rapid whole-body freezing technique was used. Indomethacin-induced constriction of the fetal ductus arteriosus was not affected by progesterone treatment.
D000818:Animals; D004373:Ductus Arteriosus / Q000187:drug effects / Q000196:embryology*; D005260:Female; D005333:Fetus; D007213:Indomethacin / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011374:Progesterone; D007213:Indomethacin