Extensive deposition of eosinophil peroxidase in Hodgkin's and non-Hodgkin's lymphomas.
To determine whether occult eosinophil degranulation occurs in lymphomas, the authors performed immunohistologic and cytochemical studies on cryostat sections from 25 consecutive lymph node biopsies. A glucose-oxidase immunohistochemical technique was employed with a murine monoclonal antibody specific for human eosinophil peroxidase (EPO). In 7 cases of Hodgkin's disease, 3 cases of T-immunoblastic sarcoma, and 1 case of small cleaved follicular center cell lymphoma with sclerosis, there was extensive and striking extracellular deposition of EPO in a granular and fibrillar pattern within the connective tissue. Similar degranulation of eosinophils was not observed in any of the benign lymph node specimens or other B-cell lymphomas. It is concluded that eosinophils extensively degranulate and release EPO in some types of lymphoma.
D000911:Antibodies, Monoclonal; D047209:Eosinophil Peroxidase; D004804:Eosinophils / Q000201:enzymology / Q000473:pathology; D006689:Hodgkin Disease / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology*; D010544:Peroxidases / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D047209:Eosinophil Peroxidase; D010544:Peroxidases