title: Pharmacokinetics and sputum penetration of ciprofloxacin in patients with cystic fibrosis.
abstract: Levels of ciprofloxacin in serum and sputum were studied for eight patients with cystic fibrosis who were infected with Pseudomonas aeruginosa. Patients were studied in a steady state on a dosage of 500 mg every 8 h. Peak levels in serum ranged from 1.27 to 5.6 mg/liter (mean, 3.16 +/- 1.27), and absorption was rapid, the time to peak concentration ranging from 0.5 to 3.0 h (mean, 1.5 +/- 0.9). The antibiotic penetrated sputum well, achieving areas under the curve of approximately 46% of those obtained in serum.
mesh_terms: D000293:Adolescent; D000328:Adult; D002939:Ciprofloxacin / Q000378:metabolism* / Q000627:therapeutic use; D003550:Cystic Fibrosis / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013183:Sputum / Q000378:metabolism*
chemical_list: D002939:Ciprofloxacin