[1H-NMR spectroscopy of the cell membranes of thymus lymphocytes in AKR mice].
360 MHz 1H NMR was used to monitor the changes of AKR mice thymus lymphocytes in cases of spontaneous and transplantable leukemia and vincristine administration. A comparison of relative signal intensities of methyl and methylene fatty acid chains protons and phosphatidylcholine headgroups protons enables to monitor leukemia development and vincristine effect. Spin-lattice relaxation curves of the same protons of leukemic thymi lymphocytes are well fitted by biexponential functions, bringing evidence for two regions with different lipid mobility.
D000406:AKR murine leukemia virus; D000818:Animals; D002462:Cell Membrane / Q000032:analysis / Q000187:drug effects; D007942:Leukemia, Experimental / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000032:analysis; D008214:Lymphocytes / Q000032:analysis* / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D013950:Thymus Gland / Q000032:analysis* / Q000187:drug effects; D013953:Thymus Neoplasms / Q000032:analysis*; D014750:Vincristine / Q000494:pharmacology
D014750:Vincristine
1H-IaMR spektroskopiia kletochnykh membran limfotsitov timusa mysheĭ AKR.