title: Defective protein C in uraemia.
abstract: Protein C activity and antigen levels were determined in 10 haemodialysis patients and 10 healthy controls matched for age and sex. Markedly decreased protein C activity was found whereas protein C antigen level was normal in uraemics. This finding, together with our recent observation that plasma protein C activity is partly normalised during haemodialysis, lead us to suggest the presence of one or more inhibitors of protein C activity in plasma from patients with uraemia.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D011486:Protein C / Q000097:blood* / Q000276:immunology; D014511:Uremia / Q000097:blood*
chemical_list: D011486:Protein C