title: Histochemistry of elastic and related fibres in the human eye in health and disease.
abstract: Although the presence of mature elastic fibres in the sclera, trabecular meshwork and Bruch's membrane of the human eye has been recognized for many years, it is only latterly that the existence of the elastic-related fibres oxytalan and elaunin has been appreciated. The microfibrillar component of elastic, oxytalan, which is present in several ocular structures in infancy, can either mature to fully-developed elastic tissue or, as in the cornea, disappear in subsequent years. Deposition of elastic fibres, particularly the incomplete forms, can occur in the post-developmental period in a variety of disease states but the stimulus and functional significance in most situations is obscure. The evidence suggests, however, that the capacity to form elastic-related tissue is not confined to any one cell type.
mesh_terms: D003285:Contractile Proteins / Q000378:metabolism*; D004547:Elastic Tissue / Q000378:metabolism*; D016326:Extracellular Matrix Proteins; D005123:Eye / Q000254:growth & development* / Q000378:metabolism; D005128:Eye Diseases / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007908:Lens, Crystalline / Q000254:growth & development; D000072260:RNA Splicing Factors; D012590:Sclera / Q000254:growth & development; D014602:Uvea / Q000254:growth & development
chemical_list: D003285:Contractile Proteins; D016326:Extracellular Matrix Proteins; D000072260:RNA Splicing Factors; C049028:elaunin; C016598:microfibrillar protein