title: Capillarosclerosis of the renal pelvis: autopsy study for estimating the incidence of phenacetin and paracetamol abuse.
abstract: This prospective study, carried out in an unselected autopsy series of 700 adults who died in or around Wuppertal, showed distinct capillarosclerosis of renal pelvic mucosa in 3% of all cases. In that renal capillarosclerosis is a partial morphologic marker of phenacetin and/or paracetamol abuse, the findings indicate that the incidence of analgesic abuse in hospitalized patients in our area is at least 3%. The incidence of renal pelvic capillarosclerosis was 1.5 times greater in females than in males.
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000328:Adult; D000368:Aged; D002196:Capillaries / Q000473:pathology; D004812:Epidemiologic Methods; D005260:Female; D005860:Germany, West; D006801:Humans; D007682:Kidney Pelvis / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010615:Phenacetin / Q000506:poisoning*; D011446:Prospective Studies; D012598:Sclerosis; D019966:Substance-Related Disorders / Q000453:epidemiology*; D014652:Vascular Diseases / Q000139:chemically induced*
chemical_list: D000082:Acetaminophen; D010615:Phenacetin