Microbial conversion of compactin (ML-236B) to ML-236A.
Approximately 1,600 fungal strains were tested for ability to convert compactin (ML-236B) to ML-236A and Emericella unguis IFO 8087 was found to be the most active. E. unguis converted ML-236B to ML-236A with a yield of over 90%.
D001203:Ascomycota / Q000378:metabolism*; D006868:Hydrolysis; D008148:Lovastatin / Q000031:analogs & derivatives*; D009281:Naphthalenes / Q000378:metabolism*; D009284:Naphthols / Q000096:biosynthesis*; D015003:Yeasts / Q000378:metabolism*
D009281:Naphthalenes; D009284:Naphthols; C012258:mevastatin; C013749:ML 236A; D008148:Lovastatin