title: Clinico-pathological study of fallopian tubes after transcervical insertion of quinacrine hydrochloride pellets.
abstract: This study lends support to others indicating the apparent safety and effectiveness of multiple transcervical insertions of quinacrine hydrochloride as pellets in 240 mg dosage to achieve permanent sterilization. In order to study the effects of the number of quinacrine pellet insertions and the site of placement of the pellets in the uterus of prehysterectomy volunteers, a scoring system of histological changes in the Fallopian tube was designed. Quinacrine pellets were deposited at the fundus using a straight inserter in 16 women, and at the cornua using a curved inserter in 17 women. Each group had at least five women receiving one, two or three insertions at one-week intervals. Results indicate that neither the number of insertions nor the place of deposition of the pellets affects the degree of tubal inflammation and fibrosis.
mesh_terms: D000328:Adult; D004343:Drug Implants; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011796:Quinacrine / Q000008:administration & dosage / Q000494:pharmacology*; D013245:Sterilization, Reproductive / Q000379:methods*
chemical_list: D004343:Drug Implants; D011796:Quinacrine