[Kinetics of the formation of AT-specific DNA-distamin complex].
Kinetics of DNA--distamin complex formation was studied by means of the stop-flow method. It has been found that the binding reaction is much faster than in the case with distamycin A and has only two stages. The differences in kinetic properties of the complexes of distamin and distamycin A with DNA has been interpreted as resulting from the formation of different bonds by protonated positively charged N-containing groups of ligands with negatively charged DNA phosphates.
D000225:Adenine; D001482:Base Composition; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D011758:Pyrroles / Q000378:metabolism*; D013053:Spectrophotometry; D013941:Thymine
D004214:Distamycins; D011758:Pyrroles; C050796:distamin; C030000:stallimycin; D004247:DNA; D000225:Adenine; D013941:Thymine
Kinetika obrazovaniia AT-spetsificheskogo kompleksa DNK-distamin.