Opiate antinociception is altered by immunemodification: the effect of interferon, cyclosporine and radiation-induced immune suppression upon acute and long-term morphine activity.
It has recently been demonstrated that various forms of immune modification result in a profound attenuation of the opiate withdrawal syndrome. Herein we investigate the extent to which some of the immune modifiers active in withdrawal attenuation affect other opiate related behaviors, namely antinociception and the development of tolerance to this effect. The observations demonstrate that immune modification by cyclosporine and irradiation exposure result in an alteration of the acute antinociceptive effect of morphine; while none of these treatments modify the development of tolerance to this property of morphine.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D004361:Drug Tolerance; D007109:Immunity / Q000528:radiation effects; D007165:Immunosuppression Therapy; D007370:Interferon Type I / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology* / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D003524:Cyclosporins; D007370:Interferon Type I; D009020:Morphine