title: Effect of breathing of a helium-oxygen mixture on adaptation to effort in humans during high-altitude hypoxia.
abstract: The study was carried out on 17 healthy males aged 20-27 years subjected for 15 minutes to submaximal effort on a cycle ergometer (Elema-Schonander) under conditions of breathing ambient atmospheric air or a helium-oxygen mixture (20% O2 + 80% He) and under hypobaric pressure simulating an altitude of 3500 m above sea level. During the experiment the heart rate was recorded with ECG, and determinations were performed of the minute volume, respiratory rate, tidal volume and systolic arterial blood pressure. In the serum of venous blood obtained before and 3 minutes after the exercise the concentrations were measured of lactate (LA), pyruvate (PA) and glucose. High-altitude hypoxia caused unifavourable changes in the adaptation to effort manifesting themselves as an increase of the values of the determined physiological and biochemical indices. On the other hand, favourable changes were observed of the reaction to exercise while the subjects were breathing the helium-oxygen mixture during high-altitude hypoxia. The minute volume increased owing to increased tidal volume, and the exercise-induced rise of lactate (LA), pyruvate (PA) and the LA/PA ratio was lower. This may suggest reduced energy cost of respiration and reduced anaerobic metabolism under these conditions.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D000531:Altitude; D006371:Helium / Q000494:pharmacology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000494:pharmacology*; D005082:Physical Exertion
chemical_list: D006371:Helium; D010100:Oxygen