title: A factor inhibiting ovum capture by the oviductal fimbriae present in endometriosis peritoneal fluid.
abstract: The cumulus-fimbria interaction was investigated in vitro with endometriosis peritoneal fluid (PF). On the oviductal fimbria of the golden hamster, incubated with endometriosis and nonendometriosis PF and culture medium 199 contained 4% bovine serum albumin (control), was placed the mouse oocyte-cumulus complex at 5-minute intervals for 60 to 70 minutes. Incubation periods until the loss of fimbrial capability of ovum capture (ovum capturability disappearance time [OCDT] ) were 23.3 +/- 2.7 (standard error of the mean), 51.7 +/- 2.9, and 61.3 +/- 0.9 minutes with endometriosis, nonendometriosis PF, and control, respectively. OCDT was significantly decreased with cell-free and ultrafiltrated endometriosis PF containing a molecular size greater than 100,000 (26.0 +/- 2.8 and 26.1 +/- 2.5 minutes, respectively). A factor inhibiting fimbrial capability of ovum capture is present in endometriosis PF.
mesh_terms: D000328:Adult; D000818:Animals; D001202:Ascitic Fluid; D006224:Cricetinae; D004715:Endometriosis / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008647:Mesocricetus; D051379:Mice; D008813:Mice, Inbred ICR; D010057:Oviducts / Q000502:physiology*; D010063:Ovum; D010066:Ovum Transport; D010298:Parity; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000150:complications / Q000503:physiopathology*