title: [Morphologic changes in the adrenal cortex in Itsenko-Cushing's syndrome].
abstract: Having studied the results of investigation of 132 patients with Icenko-Cushing syndrome (68 out of them with different structural variants of adrenal tumours, 68--without adrenal tumours), the authors came to the conclusion that adenomas of dark and mixed polymorphic cells belong to hormonally active adrenal tumours, while light-cell monomorphic adenomas belong to hormonally inactive tumours. An electron-microscopic study provides identification of signs of functional activity in adenomas and cancer tumours, to clear up the additional criteria of anaplasia in them. In patients with Icenko-Cushing syndrome, but without a tumour in the adrenal cortex ultrastructural changes in corticocytes are characteristic of the increase of cellular proliferation and the decrease of incretory activity. The follow-up results of surgical treatment were studied in all cases.
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000648:ultrastructure; D000302:Adrenal Cortex / Q000473:pathology* / Q000648:ultrastructure; D000306:Adrenal Cortex Neoplasms / Q000473:pathology / Q000648:ultrastructure; D003480:Cushing Syndrome / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D008854:Microscopy, Electron
vernacular_title: Morfologicheskie izmeneniia kory nadpochechnikov pri sindrome Itsenko-Kushinga.