Relapsing inflammatory demyelinating polyneuropathy in a diabetic patient.
Inflammatory demyelinating polyradiculoneuropathies exhibit well-known ultrastructural lesions of the peripheral nerve, both in acute cases, i.e., Guillain-Barré syndrome, and in relapsing, sub-acute and chronic cases. We present a case of relapsing inflammatory demyelinating polyradiculoneuropathy in a diabetic patient with a biopsy exhibiting these lesions, as well as a widening of the outermost myelin lamellae in some fibers. Such associated lesions are classic in experimental inflammatory demyelinating polyradiculoneuropathies, but have not been reported in human pathology.
D000818:Animals; D003711:Demyelinating Diseases / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D051379:Mice; D008854:Microscopy, Electron; D008875:Middle Aged; D009186:Myelin Sheath / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009444:Neuritis, Autoimmune, Experimental / Q000473:pathology; D010525:Peripheral Nerves / Q000648:ultrastructure*; D011129:Polyradiculoneuropathy / Q000473:pathology*
D007136:Immunoglobulins