Enhancing effect of 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran on diethylnitrosamine hepatocarcinogenesis in rats.
Enhancement of diethylnitrosamine(DENA)-induced hepatic tumor production in rats was observed by sequential exposure to 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) or 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF). This effect was more evident in the group of rats treated with 2,3,4,7,8-PenCDF (80 micrograms/rat), in which approximately 43% of this compound administered was accumulated in the liver at 8 weeks after the last treatment.
D000818:Animals; D001572:Benzofurans / Q000378:metabolism / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004052:Diethylnitrosamine; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000187:drug effects
D001572:Benzofurans; D011108:Polymers; C016068:polychlorodibenzofuran; D004052:Diethylnitrosamine; C051412:1,2,3,4,7,8-hexachlorodibenzofuran; C038890:2,3,4,7,8-pentachlorodibenzofuran