Rate-responsive pacing in patients with left ventricular failure.
Aerobic and hemodynamic performance, at rest and during exercise, has been explored in patients with either atrial synchronous ventricular or respiratory-dependent ventricular pacing. In patients with chronic AV block and normal left ventricle, the cardiac output, VO2 at maximal exercise, and work tolerance increased significantly with rate-responsive pacing in comparison with fixed ventricular pacing. Chronic AV block and left ventricle dysfunction in patients with respiratory-dependent ventricular pacing improved maximal cardiac output, VO2 anaerobic threshold, and physical work capacity. The benefit of rate-responsive pacing was found to be significantly greater in patients with left ventricle dysfunction than in patients with normal left ventricle function.
D000368:Aged; D000369:Aged, 80 and over; D002302:Cardiac Output; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure; D011897:Random Allocation; D013318:Stroke Volume