[Effect of an opioid peptide on the healing of experimental myocardial infarct].
The effect of an opioid hormone (Leu-enkephalin analog Tyr-Dala-Gly-Phe-Leu-Arg) on the healing of myocardial infarction caused by the ligation of the descending branch of the rabbit left coronary artery has been investigated. The peptide was injected intraperitoneally at a dose of 10 micrograms/kg daily. Using light and electron microscopy, the peptide has been shown to exert a pronounced stimulating effect on the healing of the necrotic zone on days 3 and 7 of the experiment. Opioid peptides are suggested to take part in the healing of various disorders.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000648:ultrastructure; D009336:Necrosis; D011817:Rabbits; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie opioidnogo peptida na zazhivlenie éksperimental'nogo infarkta miokarda.