title: Brain and brain monoamine oxidase in aging and in dementia of Alzheimer's type.
abstract: Brain MAO-B activity increases with age. The rate of increase varies in different brain regions. Brain MAO-A activity does not change with age in man and is decreased in the rat. Brain MAO-B activity in AD/SDAT is higher than in age-matched controls. The increased MAO-B activity in aging is due to an increased concentration of otherwise unchanged extrasynaptosomal MAO-B. The increase in brain MAO-B activity with age and in AD/SDAT is more pronounced in white matter than in gray matter. Platelet MAO is increased in patients with AD/SDAT.
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000201:enzymology*; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology; D001921:Brain / Q000201:enzymology* / Q000601:surgery; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008995:Monoamine Oxidase / Q000032:analysis*; D051381:Rats
chemical_list: D008995:Monoamine Oxidase; D004298:Dopamine