title: Trial of Russell's Viper Venoid. II. Human immunization with venoid. Burma, DMR Working Group on Clinical Trial of Russell's Viper Venoid.
abstract: A previously developed, refined Russell's viper venoid was given to human volunteers to find out if a protective immune response is obtainable and to observe for adverse effects. 12 subjects were immunized by subcutaneous injection of 0.5 ml of venoid followed by two booster injections at four-week intervals and six subjects served as control. Both local and systemic reactions were mild. No abnormality was detected in the laboratory tests performed. Significant rise of antibody titre was detected in all immunized subjects which persisted for 24 weeks. The antibody level achieved in human subjects is equivalent to levels seen in immunized monkeys which withstood doses of venom which would otherwise have been lethal.
mesh_terms: D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D006801:Humans; D007114:Immunization / Q000009:adverse effects; D008875:Middle Aged; D013997:Time Factors; D014757:Viper Venoms / Q000276:immunology*
chemical_list: D014757:Viper Venoms