[Inhibition of the slow-reacting substance of anaphylaxis generation by ubiquinone derivatives].
The slow-reacting substance of anaphylaxis (SRS-A) is generated in lung fragments of the actively sensitized guinea pig by an antigen-antibody reaction. The SRS-A generation in lung fragments was inhibited by its quinonyl acid (QS), and quinonyl-alcohol (QSA) derivatives of ubiquinone from a concentration as low as 10(-7) M. It was of interest that the C10 and C13 side chain length in the 6-position of ubiquinone provided the highest activity. These compounds showed no antagonistic activity towards the contractile response of guinea pig ileum to SRS-A, indicating that the compounds inhibit the biosynthesis of SRS-A.
D000707:Anaphylaxis / Q000503:physiopathology; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D013189:SRS-A / Q000096:biosynthesis*; D013329:Structure-Activity Relationship; D014451:Ubiquinone / Q000031:analogs & derivatives*
D013189:SRS-A; D014451:Ubiquinone