Is there evidence for a common amino acid sequence in proteins with membrane attaching ability?
A comparison between the primary sequence of staphylococcal protein A (SpA) and a wide range of published protein sequences revealed a limited, but striking homology in approximately two-thirds of them. The region in the SpA sequence with the common homology was identified as the octapeptide repeats comprising the cell wall peptidoglycan-binding domain. Available structural information and the known location of the proteins within their host cells suggests that this common octapeptide may be important in interaction of the protein with the cell surface (either membrane or wall).
D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism; D001426:Bacterial Proteins; D001665:Binding Sites; D066246:ErbB Receptors; D006389:Hemagglutinins, Viral; D010457:Peptidoglycan / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013205:Staphylococcal Protein A / Q000378:metabolism; D014118:Toxins, Biological / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D006389:Hemagglutinins, Viral; D010457:Peptidoglycan; D011506:Proteins; D013205:Staphylococcal Protein A; D014118:Toxins, Biological; D014764:Viral Proteins; D066246:ErbB Receptors