[Effect of clorgyline on the intensity of lipid peroxidation and on erythrocyte membrane stability in hyperoxia].
Administration of monoamine oxidase type A inhibitor clorgyline to rats before hyperoxia prevented oxygen-induced increase in diene conjugate and Shiff's base brain and plasma levels in hyperoxia. This was due to antioxidative effect of clorgyline which resulted in stabilization of blood cellular membranes. Clorgyline had a normalizing effect on extraerythrocyte hemoglobin level, total peroxidase activity and glucose-6-phosphate dehydrogenase activity in the serum.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003010:Clorgyline / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010100:Oxygen / Q000008:administration & dosage*; D010544:Peroxidases / Q000097:blood; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012545:Schiff Bases / Q000378:metabolism
D006454:Hemoglobins; D008054:Lipid Peroxides; D011437:Propylamines; D012545:Schiff Bases; D005954:Glucosephosphate Dehydrogenase; D010544:Peroxidases; D003010:Clorgyline; D010100:Oxygen
Vliianie khlorgilina na intensivnost' perekisnogo okisleniia lipidov i stabil'nost' éritrotsitarykh membran pri giperoksii.