title: [Chemotactic response of human polynuclear neutrophils after in vivo administration of spiramycin].
abstract: The chemotactic response of polymorphonuclear leukocytes using the agarose method, has been studied in six healthy volunteers, immediately prior and after a 5-day oral administration of spiramycin, 6 million units per day. The influence of spiramycin proved to be small as the directed and spontaneous migration were decreased by 21% and 18% respectively. Despite the fact that spiramycin can penetrate into leukocytes, these results indicate that no clinically relevant alterations of chemotaxis are likely under therapeutic conditions.
mesh_terms: D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects
chemical_list: D007933:Leucomycins
vernacular_title: Réponse chimiotactique des polynucléaires neutrophiles humains après administration in vivo de spiramycine.