title: Compilation of eukaryotic sequences around transcription initiation sites.
abstract: All vertebrate and invertebrate sequences present in the GenBank database have been aligned according to their mRNA start sites. For some cases the regions between positions -110 and +110 are presented. Previously, two general transcription initiation signals have been noted, the universal TATA box at position -30 and the CAAT box at -75. Our analysis indicates the presence of other signals, at least as significant as the CAAT. Inspection of the aligned sequences reveals the high concentration of G + C near mRNA initiation sites in non-mammalian vertebrates and in mammalians.
mesh_terms: D000818:Animals; D001483:Base Sequence; D007448:Invertebrates; D008322:Mammals; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger