Production of carbon monoxide in cadavers.
Carbon monoxide (CO), total hemoglobin (Hb) and carboxyhemoglobin (HbCO) in the blood and reddish discolored body cavity fluids of cadavers which had not been exposed to fire and CO were analyzed. In 13 cadavers found on land, the maximum saturation of HbCO in the blood was 3.6%, and was 10.1% in the body cavity fluids. There was only one case in which the HbCO saturations in the body cavity fluids were more than 10%. In seven drowned bodies found in fresh water, the highest HbCO saturation in the blood was 6.1%, and was 44.1% in the body cavity fluids. There were three cases in which the HbCO saturations in the body cavity fluids were more than 10%. In 12 drowned bodies found in sea water, the HbCO saturations in the blood were not more than 6.2%, and the maximum saturation of HbCO in the body cavity fluids was 83.7%. There were eight cases in which the HbCO saturations in the body cavity fluids were more than 10%. The results seem to indicate that the interpretation of HbCO saturation in the blood would not be affected significantly by the postmortem formation of CO, and that body cavity fluids should not be used for CO determination.
D000293:Adolescent; D000328:Adult; D001826:Body Fluids / Q000032:analysis; D002102:Cadaver; D002248:Carbon Monoxide / Q000032:analysis / Q000096:biosynthesis*; D002263:Carboxyhemoglobin / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D002849:Chromatography, Gas; D004332:Drowning / Q000473:pathology; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D012623:Seawater; D014867:Water
D006454:Hemoglobins; D014867:Water; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin