[Clinico-genetical studies of colonic cancer. II. Genetic analysis of predisposition to colonic cancer].
The structure of subjection to different clinical forms of colon cancer and to the morbidity as a whole approximates better the quasi-continued phenotypical model within which the contribution of genetic factors reaches 68-84%, that of incidental medium factors being 16-32%. Genetic study of heterogeneity of colon cancer clinical forms revealed that their pathogenetic community was quite high. However, the origin of colon cancer depends strongly on genetic factors (83.7 +/- 7.3%), in comparison with rectal cancer (67.9 +/- 7.1%). The analysis of colon cancer interrelation with other malignant neoplasms (including specific ones for women--breast and uterus cancer) revealed that the development of another malignant neoplasms was the result of the influence of partially common genes (20-50%) which predetermined the development of colon cancer and other malignant neoplasms. According to the data obtained in this study, the tables of repeated risk have been worked out which may be used for medico-genetic consultation.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009386:Neoplastic Syndromes, Hereditary; D010641:Phenotype; D012004:Rectal Neoplasms / Q000235:genetics; D012306:Risk; D014594:Uterine Neoplasms / Q000235:genetics
Kliniko-geneticheskie issledovaniia raka tolstoĭ kishki. Soobshchenie II. Geneticheskiĭ analiz predraspolozheniia k raku tolstoĭ kishki.