The anticlastogenic potential of fatty acid methyl esters.
To test for possible anticlastogenic effects of fatty acids, the methyl esters of fatty acids--short-chain to long-chain--were examined on busulfan in Chinese hamster bone-marrow cells using the chromosome aberration test. When the experimental animals were treated with fatty acid esters and the mutagen, the chromosome-breaking actions of busulfan were not modulated by the short-chain fatty acids, but the fatty acids from lauric acid (C12) up to nonadecanoic acid (C19) reduced the rate of aberrant metaphases from 9.4 to about 3% at doses of 100 mg/kg and less. Other chemical properties of the fatty acids (saturated or not, number of double bonds, even- or odd-numbered) had no influence on the anticlastogenic effects. The only exceptions to this rule were arachidonic acid, which had no effect, and gamma-linolenic acid, which had no consistent effect on the action of busulfan.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002066:Busulfan / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004952:Esters / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D008297:Male; D009154:Mutation
D004952:Esters; D005227:Fatty Acids; D002066:Busulfan