title: Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.
abstract: Regulation of the production of erythropoietin occurs in the kidney and liver largely through control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control value by 4 to 8 h. A 20-base sequence immediately upstream from the reported erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S rRNA.
mesh_terms: D000740:Anemia / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D004921:Erythropoietin / Q000235:genetics*; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D004921:Erythropoietin