title: [Lipid metabolic indices in man during head-down tilt hypokinesia and their correction].
abstract: Twenty one test subjects exposed to head-down tilt for 120 days were subdivided to four groups: Group 1--nine subjects used as controls, Group 2--three bed rested subjects who performed regular exercises, Group 3--four bed rested subjects who were given selected drugs, including Vitamin F-99 that influenced lipid metabolism, and Group 4--four bed rested subjects who performed regular exercises and received Vitamin F-99. At different stages of bed rest and recovery the content of lipoprotein fractions and lipids of different classes in serum was measured by thin-layer chromatography. The concentration of cholesterol in biliary lipids was determined. In Group 1 and 2 subjects bed rest led to a drastic and significant increase of cholesterol esters in blood, a decrease of phospholipids, variations of triglycerides and non-esterified fatty acids, and a lower percentage content of alpha-lipoproteins. The use of Vitamin F-99 produced positive changes in the above parameters of lipid metabolism (it normalized the level of cholesterol and phospholipids). In Group 4 subjects the effect of exercise combined with drugs was most distinct.
mesh_terms: D001510:Bed Rest; D001646:Bile / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004338:Drug Combinations / Q000627:therapeutic use; D006801:Humans; D008041:Linoleic Acids / Q000627:therapeutic use; D008042:Linolenic Acids / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D005082:Physical Exertion; D011187:Posture; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D008041:Linoleic Acids; D008042:Linolenic Acids; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; C050831:linoleic acid, linolenic acid drug combination; D002784:Cholesterol
vernacular_title: Nekotorye pokazateli lipidnogo obmena u cheloveka v usloviiakh antiortostaticheskoĭ gipokinezii i ikh korrektsiia.