Motilin in chronic idiopathic constipation.
The plasma motilin levels were studied in seven patients with severe long-standing idiopathic constipation before and after a fat-rich test meal. The results were compared with those of a control group consisting of 10 apparently healthy persons with normal bowel function. The constipated patients had reduced basal motilin levels and a reduced motilin release after the test meal. Motilin is known to stimulate intestinal motility by inducing interdigestive descending contractions in the stomach and small intestine. A defective motilin release may therefore play a part in the pathogenesis of idiopathic constipation.
D000328:Adult; D002908:Chronic Disease; D003248:Constipation / Q000097:blood* / Q000209:etiology; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D005502:Food; D005769:Gastrointestinal Motility; D006801:Humans; D008875:Middle Aged; D009037:Motilin / Q000097:blood*; D011863:Radioimmunoassay
D004041:Dietary Fats; D009037:Motilin