The influence of vagotomy on the respiratory effects of injected phenyl diguanide in anaesthetized rabbits.
The effects of intravenous injections of phenyl diguanide (PDG) on pattern of breathing were studied before, immediately after, and some time after bilateral cervical vagotomy in anaesthetized rabbits. The characteristic tachypnoea observed in the intact animals could not be produced for several minutes after bilateral vagotomy, but after 15 min could be elicited again. This sequence of events was not essentially modified by cutting the glossopharyngeal nerves nor by injection of local anaesthetic into the pericardial sac. We suggest that the respiratory effects of PDG in the rabbit, previously considered to originate mainly from peripheral receptors, including those of the lungs, has a considerable central component which has previously been obscured by the short-term effects of vagotomy.
D000768:Anesthesia, General; D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D003714:Denervation; D005260:Female; D005930:Glossopharyngeal Nerve / Q000502:physiology; D007267:Injections; D007275:Injections, Intravenous; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D010496:Pericardium; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D014628:Vagotomy
D001645:Biguanides; D008012:Lidocaine; C008846:phenyl biguanide