Expression of c-mos proto-oncogene in undifferentiated teratocarcinoma cells.
Proto-oncogene c-mos, the cellular homologue of the transforming gene of Moloney murine sarcoma virus, has been characterized by the lack of expression in a variety of differentiated tissues, possibly because of the existence of an inhibitory upstream sequence. We detected mos-related transcripts in undifferentiated embryonal carcinoma cells of pluripotential cell line 311. The sizes of three major transcripts detected were estimated to be 1.8, 4.6 and 6.1-kilobases (kb) by northern analysis. Furthermore, these transcriptions were suppressed when the cell differentiation was induced by retinoic acid. Taken together, the results suggest that mos product plays a role in early stages of development.
D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation; D002460:Cell Line; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D051379:Mice; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes; D013724:Teratoma; D014158:Transcription, Genetic