title: Comparative micronucleated erythrocyte cell induction in three cyprinids by five carcinogenic-mutagenic chemicals.
abstract: The common carp, tench and grass carp were used to study micronucleus induction in erythrocyte cells after i.p. administration, and the direct effects of five carcinogenic-mutagenic chemicals (aflatoxin B1, Aroclor 1254, benzidine, benzo(a)pyrene and 20-methylcholanthrene). Injections with distilled water and corn oil served as the two control groups. The induction rate of micronuclei in the cells of fish exposed to the test chemicals for 48 h clearly showed not only dose-response increase in micronucleus frequency compared with the control, but also a species response dependency. The fish system proved to be an excellent means to detect or investigate water-borne or internally administered pollutants.
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002347:Carps / Q000097:blood; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003530:Cyprinidae / Q000097:blood*; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D009153:Mutagens