title: Hepatic contribution to satiation of salt appetite in rats.
abstract: We examined the influence of hepatic-portal vein infusion of NaCl and of hepatic vagotomy on 3% NaCl solution drinking by sodium-deficient rats. Combined dietary sodium restriction and administration of the natriuretic agent, furosemide (5 mg), produced a vigorous appetite for 3% NaCl solution that was attenuated by portal infusion of NaCl. Whereas infusions (1 ml/30 min) of NaCl into the hepatic-portal vein in concentrations as low as 0.15 M (isotonic) significantly reduced 3% NaCl consumption, a higher concentration (0.6 M) infused into the jugular vein, or portal infusions of KCl (0.6 M) or sucrose (1.2 M), were ineffective. Rats with selective hepatic vagotomy displayed an attenuated appetite for salt whether or not they received hepatic-portal NaCl. This was not due to altered excretion of sodium. Taken together, these results suggest that the liver or portal vein can provide a sodium-specific neural signal capable of attenuating the appetite for salt and this information is transferred to the brain by fibers in the hepatic vagus that fire in reciprocal relationship with portal sodium concentration.
mesh_terms: D000818:Animals; D004032:Diet; D004039:Diet, Sodium-Restricted; D005665:Furosemide / Q000494:pharmacology; D007262:Infusions, Intravenous; D008099:Liver / Q000294:innervation / Q000502:physiology*; D008102:Liver Circulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects; D012528:Satiety Response / Q000187:drug effects; D012965:Sodium Chloride / Q000008:administration & dosage / Q000097:blood*; D014628:Vagotomy
chemical_list: D012965:Sodium Chloride; D005665:Furosemide