Estrogens as natural antioxidants of membrane phospholipid peroxidation.
Estrogens, such as estrone, estradiol and estriol, were tested as possible antioxidants of lipid peroxidation induced by Fe3+-ADP-adriamycin or Fe3+-ADP-ascorbate. The estrogens with phenolic structure possessed substantial activities with respect to the inhibition of lipid peroxidation. Concentrations of estradiol and estriol required to achieve 50% inhibition of membrane phospholipid peroxidation were about 4- and 6-times that of alpha-tocopherol, respectively.
D000818:Animals; D000975:Antioxidants; D004967:Estrogens / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D000975:Antioxidants; D004967:Estrogens; D008054:Lipid Peroxides; D008081:Liposomes; D008563:Membrane Lipids; D010743:Phospholipids