Biosynthesis of valanimycin.
In the biosynthesis of valanimycin, valine is mostly incorporated into the isobutyl moiety of the antibiotic. The alpha-substituted acrylic moiety of valanimycin is derived from alanine. However, a part of alanine is metabolized into valine, thus incorporated also into the isobutyl moiety. Anaerobic conditions and some reducing agents strongly inhibit the biosynthesis.
D000409:Alanine / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001391:Azo Compounds / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D003545:Cysteine / Q000494:pharmacology; D007930:Leucine / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D014316:Tritium; D014633:Valine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D002250:Carbon Radioisotopes; D014316:Tritium; C048267:valanimycin; D007930:Leucine; D014633:Valine; D008274:Magnesium; D003545:Cysteine; D000409:Alanine