[Compounds with potential antitumor activity. IV. Synthesis and antileukemic activity of 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylenediamine].
Some 1-aryl-N,N'-di-[2-(1,3,4-thiadiazolyl)]methylendiamines were synthetized and tested against lymphocytic murine leukemia P 388. Compounds (I)-(III), (VIII)-(XII) and (XVIII)-(XIX) showed significant by prolongation the survival time of tumor-bearing mice (T/C% 129-194).
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D003959:Diamines; D013830:Thiadiazoles
Composti a presumibile attività antitumorale. Nota IV. Sintesi ed attività antileucemica di 1-aril-N,N'-di-[2-(1,3,4-tiadiazolil)]metilendiamine.