Selective use of palmitic acid over stearic acid for synthesis of phosphatidylcholine and phosphatidylglycerol in lung.
The incorporation of [3H]palmitic acid and [14C]stearic acid into phospholipids in rabbit lung tissue was studied. Under equal molar concentrations of palmitate and stearate, palmitate was incorporated to the 1- and 2-positions of phosphatidylcholine (PC) and phosphatidylglycerol (PG) 2-3 times more than stearate. By contrast, palmitate was 30% less than stearate in phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine. These results suggest that preferential utilization of palmitate over stearate, rather than substrate availability, determines the high content of palmitoyl at the 1- and 2-positions of PC and PG in lung.
D000818:Animals; D002250:Carbon Radioisotopes; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D010715:Phosphatidylglycerols / Q000096:biosynthesis*; D010743:Phospholipids / Q000096:biosynthesis*; D011817:Rabbits; D013229:Stearic Acids / Q000378:metabolism*; D013329:Structure-Activity Relationship
D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; D010743:Phospholipids; D013229:Stearic Acids; D019308:Palmitic Acid; C031183:stearic acid