Abnormal karyotype in the chorion, not confirmed in a subsequently aborted fetus.
An abnormal fetal karyotype, containing a del 16(q21-qter) as an extra chromosome, was diagnosed in all 14 metaphases examined in a sample of chorionic villous biopsy material. After elective abortion a mosaicism for this cell-line together with a normal one was detected in the chorionic tissue. Fibroblast cultures from several fetal skin biopsies all revealed a normal karyotype.
D000025:Abortion, Eugenic; D000328:Adult; D002823:Chorion / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure; D005189:False Positive Reactions; D005260:Female; D005333:Fetus / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D011296:Prenatal Diagnosis