Study of the antiaggregating activity of new phenacyl-piperazine derivatives.
The antiplatelet activity of twelve new derivatives of phenacyl-piperazine was studied. Eight of them proved to be inactive by Born's method. The other four compound partially inhibited the aggregating effects induced by adrenaline and ADP, but did not prevent the effects produced by collagen. Although it was not possible to establish any relationship between chemical structure and antiplatelet activity, it looks as if there is a certain relationship between the analgesic and the antiplatelet effect. The compounds tested did not usually modify bleeding time.
D000098:Acetophenones / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D000897:Anti-Ulcer Agents; D001760:Bleeding Time; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D010879:Piperazines / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*
D000098:Acetophenones; D000700:Analgesics; D000897:Anti-Ulcer Agents; D010879:Piperazines