Cholesterol feeding attenuates endothelium-dependent relaxation response to acetylcholine in the main pulmonary artery of chickens.
The endothelium-dependent relaxation in response to acetylcholine was significantly less in pulmonary artery strips from chickens fed 5% cholesterol for 4 weeks than in strips from animals fed an 'ordinary' diet. No relaxation was observed in the strips from either group when the endothelium was disrupted or the strips were pretreated with hydroquinone. These results indicate that the relaxing effect of acetylcholine is endothelium-dependent and that hypercholesterolemia leads to an impairment of the endothelium-mediated relaxation response of the pulmonary artery strips to acetylcholine.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D002645:Chickens; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D006937:Hypercholesterolemia / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects*
D002791:Cholesterol, Dietary; D000109:Acetylcholine