[Effect of prolonged intracardiac catecholamine infusion on the active nature of neuronal uptake in the atrium of the rat].
A preliminary saturation of the blood with catecholamines enhanced the ability of atria for neuronal uptake of labeled 3H-noradrenaline. Reserpine potentiated the effect. Issuing from the pattern of formation and disintegration of the agonist receptor complexes, the data obtained are interpreted as the mechanism of increasing the heart adrenoreactivity. The activating effect of catecholamines on the neuronal uptake has a certain threshold and does not depend on the duration of pre-infusion or concentration of administered catecholamines.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004357:Drug Synergism; D006321:Heart / Q000187:drug effects / Q000294:innervation*; D006325:Heart Atria; D009206:Myocardium / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D002395:Catecholamines; D012110:Reserpine; D009638:Norepinephrine
Vliianie dlitel'noĭ vnutriserdechnoĭ infuzii katekholaminov na aktivnost' neĭronal'nogo zakhvata v predserdii krysy.