Hypoaldosteronism in piglets induced by carbadox.
An exploratory study was made of the mechanisms underlying the toxic action of carbadox in young pigs: dehydration, loss of appetite and at autopsy seemingly specific and selective structural alterations of the glomerular zone of the adrenal cortex. Administration of carbadox in the feed, in dosages of 150 ppm (approximately 6 mg X kg-1 b. wt X day-1) caused a rapid decline in the plasma aldosterone levels (to 10% of control) followed by significant changes in the sodium and potassium levels in blood. Characteristic for the toxic action of carbadox are the rapid and seemingly selective and specific alterations in the aldosterone-releasing zona glomerulosa of the adrenals. Our results indicate that with carbadox a functional and possibly reversible extirpation of the adrenal zona glomerulosa can be achieved in pigs.
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology*; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D002218:Carbadox / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011188:Potassium / Q000097:blood; D011810:Quinoxalines / Q000633:toxicity*; D012964:Sodium / Q000097:blood; D013552:Swine
D011810:Quinoxalines; D000450:Aldosterone; D012964:Sodium; D002218:Carbadox; D011188:Potassium