Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.
A soil isolate named as Micromonospora echinospora subsp. armeniaca subsp. nov. KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes. From the physico-chemical properties, one of these components was identified with lipiarmycin and others were found to be new antibiotics. Each component includes two chlorine atoms and the molecular weights of A and B2, C, and D are 1,058, 1,042 and 1,056, respectively. The structural differences were characterized by NMR analyses.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D000077732:Fidaxomicin; D006027:Glycosides / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000378:metabolism*; D013055:Spectrophotometry, Infrared
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006027:Glycosides; D000077732:Fidaxomicin