[Effect of heparin on the vascular thrombocytic link of the hemostatic system and pathogenetic correction of ensuing disorders].
Intravenous injection of heparin (750 U/kg) induced thrombocytopenia, intravascular platelets aggregation and decreased prostacyclin-like vascular wall activity. Adverse side-effects may be prevented by injection of heparin in complex with nicotinic acid (1.5 mg/kg) and dipyridamole (2.5 mg/kg).
D000818:Animals; D004176:Dipyridamole / Q000008:administration & dosage / Q000627:therapeutic use*; D006494:Heparin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009525:Niacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D006494:Heparin Antagonists; D009525:Niacin; D004176:Dipyridamole
Vliianie geparina na sosudisto-trombotsitarnoe zveno sistemy gemostaza i patogeneticheskaia korrektsiia voznikaiushchikh narusheniĭ.