Hematological and blood pressure studies in the CCl4 treated rats.
Hematological parameters were studied in normotensive and spontaneous hypertensive rats along with those treated with chronic subcutaneous injections of CCl4. The normotensive animals treated with CCl4 demonstrated an erythrocytosis with an increase in the hematocrit levels. A lymphocytosis was seen with neutropenia in both CCl4 treated and untreated normotensive groups. The SHR animals compared to their normotensive counterparts had a lesser degree of lymphocytosis with an increase in the number of neutrophils. There was no blood pressure change in the normotensive CCl4 treated group, however a significant blood pressure difference was observed in the SHR group after CCl4 treatment.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000627:therapeutic use / Q000633:toxicity*; D004906:Erythrocyte Count; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007501:Iron / Q000097:blood; D007958:Leukocyte Count; D008218:Lymphocytosis / Q000139:chemically induced; D008297:Male; D009503:Neutropenia / Q000150:complications; D010976:Platelet Count; D011086:Polycythemia / Q000139:chemically induced; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D006454:Hemoglobins; D002251:Carbon Tetrachloride; D007501:Iron