Study of the elimination kinetics of torasemide, a novel loop diuretic, in renal insufficiency.
The plasma concentration of torasemide was determined as a function of time in 8 patients with impaired renal function (creatinine clearance less than or equal to 25 ml/min). The elimination half-life (1.3 to 3.8 h), the volume of distribution (0.12 to 0.29 l/kg), and the total body clearance (0.02 to 0.10 l/kg X h) were similar to those observed in normal volunteers.
D000328:Adult; D000368:Aged; D004232:Diuretics / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000378:metabolism*; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D000077786:Torsemide