[Study on suppressed uptake by the liver in 67Ga scintigraphy].
During the past 3 years, we have performed 1525 studies of 67Ga scintigraphy and 38 cases of these showed suppressed liver uptake; 19 cases after chemotherapy, 13 cases with liver dysfunction and 6 cases with competitive blockade. Many cases in chemotherapy used cyclophosphamide and vincristine, and were performed 67Ga scan within 1 week after chemotherapy. In cases showed suppressed uptake by liver after chemotherapy, serum Fe was markedly increased and UIBC was markedly decreased (p less than 0.01). This suggested that serum Fe influenced suppressed uptake by liver more than carrier-protein, disturbed hepatic cells, and receptors.
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D007501:Iron / Q000097:blood; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D014750:Vincristine / Q000627:therapeutic use
D005710:Gallium Radioisotopes; D014750:Vincristine; D003520:Cyclophosphamide; D007501:Iron