title: Urinary phenylethylamine correlates positively with hypomania, and negatively with depression, paranoia, and social introversion on the MMPI.
abstract: It has been suggested that phenylethylamine (PEA) may play a role in the modulation of affective behavior. The aim of the present study was to test this hypothesis. Urinary PEA excretion was determined in 32 drug-free healthy volunteers, and the MMPI was used for personality assessment. In support of this hypothesis, a significant positive correlation between PEA and hypomania (r = 0.50; P less than 0.05) and a significant negative correlation between PEA and depression (r = -0.58; P less than 0.01) was observed in the female subgroup. Furthermore, PEA correlated significantly negatively with hypochondriasis (r = -0.65; P less than 0.01), paranoia (r = 0.49; P less than 0.05), and social introversion (r = -0.60; P less than 0.05). These results are the first evidence in normal individuals either that PEA itself might play a role in the modulation of affective behavior, or alternatively that PEA could be related to mechanisms responsible for the modulation of affective behavior.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000523:psychology / Q000652:urine*; D003866:Depressive Disorder / Q000523:psychology / Q000652:urine*; D005260:Female; D006801:Humans; D007439:Introversion, Psychological; D008950:MMPI; D008297:Male; D010259:Paranoid Disorders / Q000523:psychology / Q000652:urine*; D010627:Phenethylamines / Q000652:urine*; D011594:Psychometrics
chemical_list: D010627:Phenethylamines; C029261:phenethylamine