Sickle cell membranes and oxidative damage.
Sickle erythrocytes and their membranes are susceptible to endogenous free-radical-mediated oxidative damage which correlates with the proportion of irreversibly sickled cells. The suppression of incubation-induced oxidative stress by antioxidants, free radical scavengers and an iron chelator suggest that oxidation products of membrane-bound haemoglobin contribute towards the pathology of the disease.
D000755:Anemia, Sickle Cell / Q000097:blood*; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D003676:Deferoxamine / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004913:Erythrocytes, Abnormal / Q000187:drug effects / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D010084:Oxidation-Reduction
D000975:Antioxidants; D005609:Free Radicals; D007501:Iron; D003676:Deferoxamine; D001205:Ascorbic Acid