title: Oxygen delivery and consumption in patients with hyperdynamic septic shock.
abstract: We analyzed the relationship of increases in oxygen delivery to changes in oxygen consumption in ten patients with hyperdynamic septic shock. Increases in oxygen delivery from 413 +/- 14 (SEM) to 535 +/- 19 ml/min X m2 (p less than .01) were associated with increases in oxygen consumption from 136 +/- 10 to 161 +/- 5 ml/min X m2 (p less than .05). Arterial lactate decreased from 4.6 +/- 1.6 to 2.1 +/- 0.3 mmol/L (p less than .05). These observations suggest that oxygen utilization is perfusion-limited in hyperdynamic septic shock.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D012772:Shock, Septic / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D007773:Lactates; D019344:Lactic Acid; D010100:Oxygen