Interactions of functionalized polymeric liposomes having a porphinato-iron complex with some biological cells and components in vitro.
The hemocompatibility of functionalized polymeric liposome particles (diameter: 20-32 nm), which have a synthetic porphinato-iron complex in their polymerized bilayers and can carry oxygen, was studied in vitro. The ultramicroparticles did not induce hemolysis, platelet aggregation and plasma coagulation directly and were stable against hydrolysis by phospholipases A2 and D.
D000818:Animals; D001777:Blood Coagulation; D004285:Dogs; D006461:Hemolysis; D007700:Kinetics; D008051:Lipid Bilayers; D008081:Liposomes; D008297:Male; D008954:Models, Biological; D010713:Phosphatidylcholines; D010739:Phospholipase D / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D010974:Platelet Aggregation; D051381:Rats; D011919:Rats, Inbred Strains
D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D010741:Phospholipases A; D010739:Phospholipase D