[Role of heparin in erythrocyte aggregation].
The effect of two heparin fractions containing 3 (HP-3) and 4 (HP-4) residues of sulfuric acid per dimer of polymers on the capacity of hyaluronate potassium (HUP) and protein-chondroitin-keratan-sulfate potassium (PCHKSP) to aggregate rabbit erythrocytes suspended in 0.15 M NaCl was studied. HP-3 (0.3-5.0 mg X ml-1) and HP-4 (0.3-5.0 mg X ml-1) was inhibited the aggregating action on the erythrocytes of HUP. Fraction HP-3 (0.3-5.0 mg X ml-1) was activated the aggregating action on the erythrocytes of PCHKSP. Fraction HP-4 when the concentration of their biopolymer were 0.3 mg X ml-1 so activated the aggregating action of PCHKSP, but when the concentration HP-4 0.6-5.0 mg X ml-1 was inhibited the aggregating action PCHKSP. The mixture of HP-3 (1.2 mg X ml-1) and HP-4 (1.2 mg X ml-1) was not influenced on aggregating action of PCHKSP.
D000818:Animals; D011508:Chondroitin Sulfate Proteoglycans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007632:Keratan Sulfate / Q000494:pharmacology; D000071234:Lumican; D011817:Rabbits; D012996:Solutions
D011508:Chondroitin Sulfate Proteoglycans; D000071234:Lumican; D012996:Solutions; D006820:Hyaluronic Acid; D006493:Heparin; D007632:Keratan Sulfate
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