3-Acetyl-4''-isovaleryl tylosin for prevention of swine dysentery.
The 21 field isolates of Treponema hyodysenteriae which were tested were sensitive to 3-acetyl-4''-isovaleryl tylosin (AIV); the minimal inhibitory concentration was 0.25 to 16 micrograms/ml. 3-Acetyl-4''-isovaleryl tylosin administered prophylactically to pigs at concentrations of 5 to 100 mg/kg of feed and tylosin at 110 mg/kg of feed for 28 or 31 days prevented swine dysentery induced by tylosin-sensitive T hyodysenteriae strain SQ2; 15 nonmedicated, inoculated control pigs had bloody diarrhea, and 9 pigs died. In 2 additional trials, AIV administered prophylactically for 28 days at 55 or 110 mg/kg of feed prevented swine dysentery induced by tylosin-insensitive T hyodysenteriae strain B204. All of the inoculated principal pigs medicated with AIV at 55 or 110 mg/kg of feed or carbadox at 55 mg/kg of feed and the noninoculated sentinel pigs for each group had solid feces throughout the 56-day trial. In the nonmedicated, inoculated control groups, bloody diarrhea began at 4 to 5 days after inoculation was done, and 9 of 10 principal pigs and 6 of 9 sentinel pigs had dysentery; 2 pigs died. In the groups medicated with AIV at 27.5 or 5.5 mg/kg of feed, all 5 principal pigs and 3 or 4 sentinel pigs in each group had dysentery; 3 or 4 pigs in each group died. In the group medicated with tylosin at 110 mg/kg of feed, 7 of 10 principal pigs and all 9 sentinel pigs had dysentery; 1 pig died.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D002218:Carbadox / Q000627:therapeutic use; D004403:Dysentery / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D007933:Leucomycins / Q000494:pharmacology / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000517:prevention & control*; D014208:Treponema / Q000187:drug effects; D014211:Treponemal Infections / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D015645:Tylosin / Q000031:analogs & derivatives*
D007933:Leucomycins; C031783:3-acetyl-4''-isovaleryltylosin; D002218:Carbadox; D015645:Tylosin