Long-term effects of diethylstilbestrol (DES) on genetically obese and non-obese female Zucker rats.
The long-term effects of diethylstilbestrol (DES) were studied in genetically obese and non-obese female Zucker rats. Experimental animals were implanted subcutaneously with a 15 mg pellet of DES at the beginning of the experiment, and again three months later. Weight-matched control animals received no treatment. Rats were sacrificed 6.5 months after the first implantation. The animals treated with DES had significantly lower body weights at sacrifice than the control rats; the percentage reduction was comparable for the obese and lean animals. Treatment was associated with significant reductions in body length, food intake, water intake and weights of an inguinal fat pad, heart, liver, kidneys and adrenals. In contrast, weight of the reproductive tract and pituitary gland were significantly higher in the treated rats. Effects of DES treatment were comparable in lean and obese rats.
D000818:Animals; D001835:Body Weight; D004054:Diethylstilbestrol; D004326:Drinking; D004435:Eating; D004967:Estrogens / Q000502:physiology*; D005260:Female; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D004967:Estrogens; D004054:Diethylstilbestrol