Dietetic treatment of essential mixed cryoglobulinemia.
On the basis of a functional model of the system removing immune complexes from blood (SRIC), we may consider essential mixed cryoglobulinemia (EMC) as a condition of SRIC insufficiency due to an excessive input of immune complexes. Thus, we tried to lower the global input to SRIC in 10 symptomatic EMC patients by giving them a hypoantigenic diet for 2-3 weeks, with a gradual return on free diet in the subsequent 12 weeks. After 10-60 days from the beginning of diet, all patients experienced significant reductions of symptoms' intensity (p = 0.005), of cryoprecipitate protein content (p = 0.025) and of circulating immune complex-like material (p = 0.035). A reduction of the prednisone dosage (p less than 0.005) in the 7 patients on continuous treatment was made possible. After the return on free diet, 6 patients had a relapse. Although preliminary, our results show that a hypoantigenic diet is able to lower circulating cryoglobulin levels and to clinically improve the EMC, probably by making the SRIC more functionally efficient.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003165:Complement System Proteins / Q000032:analysis; D003449:Cryoglobulinemia / Q000178:diet therapy*; D003450:Cryoglobulins / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011092:Polyethylene Glycols / Q000494:pharmacology; D011241:Prednisone / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D011092:Polyethylene Glycols; D003165:Complement System Proteins; D011241:Prednisone