Augmentation of synaptic responses in the dentate gyrus by daily electrical stimulation of the amygdala in cats.
When the amygdaloid complex was electrically stimulated, polysynaptic evoked potentials were produced in the ipsilateral dentate gyrus of the hippocampal formation. Twenty-four hours after tetanic stimulation of the amygdala, the dentate response to single test pulses was found to be increased in amplitude. Stimulation trains presented at a rate of 1/day had a cumulative effect on the dentate evoked potential, which attained 5-10 times the original response in amplitude. The results imply that the efficiency of synaptic transmission in the amygdalo-hippocampal pathway can be modified, associated with amygdaloid kindling.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D007696:Kindling, Neurologic; D009434:Neural Pathways / Q000502:physiology; D013569:Synapses / Q000502:physiology; D013997:Time Factors