Is vigor of regeneration a key factor in recovery from peripheral nerve injuries?
The nerve-growth-promoting effects of the tricyclic antidepressant, imipramine, were tested on the sympathetic ganglion of chickens and on the sciatic nerve of rats. A powerful neuronotrophic action was observed in vitro, but the utilization of the drug in vivo did not modify the functional recovery from a crush lesion.
D000818:Animals; D007099:Imipramine / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries
D007099:Imipramine