title: Inverted Y chromosome polymorphism in the Gujerati Muslim Indian population of South Africa.
abstract: An inverted Y chromosome has been found at a very high frequency in a Muslim Indian community living in the Johannesburg-Witwatersrand area of the Transvaal Province of South Africa: 8 of 141 (5.7%) retrospectively identified Indian males had an inv(Y)(p11.2q11.23) and all were of the Muslim faith. The inversion was found in 22 of 72 (30.5%) prospectively studied normal Muslim Indian males. All the carriers of the inversion were Gujarati-speakers whose families migrated to the Transvaal from the Gujerat Province of India during the first half of this century. The origins of the ancestors of the individuals with inv(Y) were traced to a small village, Kholvad, near the city of Surat, and some neighbouring villages. The polymorphic frequency of the inv(Y) has probably been produced through random genetic drift in a reproductively isolated community, maintained by strict endogamous marriage customs based on religious and linguistic affiliations. There was no indication that the inverted Y was associated with any reproductive disadvantages.
mesh_terms: D044383:Black People; D007446:Chromosome Inversion; D005006:Ethnicity; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency; D006801:Humans; D007194:India / Q000208:ethnology; D008297:Male; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012189:Retrospective Studies; D013019:South Africa; D044465:White People; D014998:Y Chromosome / Q000648:ultrastructure*