Nomifensine and psychological dependence--a case report.
This case report indicates that nomifensine has not only a specific antidepressant profile but also a dose dependent addictive potential in patients with "addictive problems". Nomifensine supports not only norepinephrine transmission, but also acts on dopamine metabolism and this may be responsible for the stimulation of motor activity. This is in contrast to more frequently used tri- and tetracyclic antidepressants. This case report further supports other observations that several patients have psychological withdrawal difficulties after long term treatment with nomifensine in high doses (400-600 mg).
D000328:Adult; D005260:Female; D006801:Humans; D009627:Nomifensine / Q000009:adverse effects; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D009627:Nomifensine