title: [Effectiveness of rectal metromidazole in acute infantile appendicitis].
abstract: Thirty two consecutive children who underwent surgery for suspected acute appendicitis, were treated with prophylactic metronidazole suppositories. A serum sample was taken at surgery to determine the serum concentration of the drug. After a preoperative dose of 15-20 mg/kg the minimal bactericidal concentration was achieved in almost all cases at the time of anesthetic induction. This drug showed an optimal biodisponibility when used rectally and no side-effects was noted. Neither a wound-infection, nor a wound-sepsis was reported and a satisfactory outcome was registered. We conclude that rectal dosing with metronidazole is effective for prophylactic wound infection in acute appendicitis.
mesh_terms: D000285:Administration, Rectal; D000293:Adolescent; D001064:Appendicitis / Q000601:surgery*; D001424:Bacterial Infections / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D011292:Premedication; D013488:Suppositories; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D013488:Suppositories; D008795:Metronidazole
vernacular_title: Eficacia del metronidazol rectal en la apendicitis aguda infantil.