Efficacy of tolciclate solution in patients with tinea pedis.
Forty patients with tinea pedis were treated for six weeks in a double-blind study with a tolciclate or placebo solution. The tolciclate solution demonstrated moderate efficacy compared with placebo. The finding of positive KOH preparations in a significant number of tolciclate-treated patients with persistently negative cultures suggests that the vehicle used (polyethylene glycol-400) may not provide adequate penetration of this effective antifungal agent. No adverse effects were noted.
D000279:Administration, Cutaneous; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D012996:Solutions; D013859:Thiocarbamates / Q000008:administration & dosage*; D014008:Tinea Pedis / Q000188:drug therapy*
D000935:Antifungal Agents; D012996:Solutions; D013859:Thiocarbamates; C013305:tolciclate