Thialysine utilization by thialysine resistant CHO cells.
Thialysine resistant CHO cells utilize thialysine added to the culture medium to a lesser extent than the parental cells. Thialysine is utilized in protein synthesis and it is incorporated into proteins in place of lysine. The parental strain substitutes up to 11% of protein lysine by thialysine, while variant cells substitute a maximum of 5% of protein lysine.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003545:Cysteine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D004351:Drug Resistance; D014176:Protein Biosynthesis
D000596:Amino Acids; C000204:S-2-aminoethyl cysteine; D003545:Cysteine