title: Large-surface hemodialysis.
abstract: A hemodialysis device with a surface of 5 m2, a blood flow (QB) of 500 ml/min, and a dialysate flow (QD) of 1,000 ml/min has enabled the authors to obtain in 6 h/week the same clearances for urea, creatinine, uric acid, phosphates, and vitamin B12 as has conventional hemodialysis (CH), which takes from 12 to 15 h/week. Twenty-five patients were hemodialyzed throughout 1 year with CH and another year with large-surface hemodialysis, 20 with a creatinine clearance (CCr) of 0.5 ml/min and 5 with a CCr between 0.5 and 4.5 ml/min. All followed a free diet and led a normal life. Hemodialysis time was 6 h/week, and the results obtained were equal to those of the previous year with a CH of 12 h/week. The use of a bicarbonate dialysate rich in glucose, with a relatively high level of potassium and sodium, can avoid the disequilibrium syndrome caused by quick hemodialysis and makes possible the removal of excess liquid in only 6 h/week, without disturbances for the patient.
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D006435:Renal Dialysis; D014508:Urea / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D010710:Phosphates; D014508:Urea; D003404:Creatinine; D000469:Alkaline Phosphatase; D002118:Calcium