Simultaneous high-performance liquid chromatographic determination of antazoline phosphate and tetrahydrozoline hydrochloride in ophthalmic solution.
A method for the determination of 2-[(N-phenyl)benzylaminomethyl]-2-imidazoline X H3PO4 (antazoline phosphate) and 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazoline X HCl (tetrahydrozoline hydrochloride) in ophthalmic solution is described. The pharmaceutical preparation is analysed directly by reversed-phase ion-pair high-performance liquid chromatography and the method is very rapid, selective and simple.
D000865:Antazoline / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007093:Imidazoles / Q000032:analysis*; D007202:Indicators and Reagents; D009883:Ophthalmic Solutions / Q000032:analysis*; D012997:Solvents
D007093:Imidazoles; D007202:Indicators and Reagents; D009883:Ophthalmic Solutions; D012997:Solvents; D000865:Antazoline; C005810:tetrahydrozoline