In vitro activity of efrotomycin, ciprofloxacin, and six other antimicrobials against Clostridium difficile.
The susceptibility of 69 clinical isolates of Clostridium difficile from the Minneapolis Veterans Administration Medical Center and 29 C. difficile strains from other hospitals to efrotomycin, ciprofloxacin, and six other antimicrobials was tested in vitro by agar dilution. Ciprofloxin (MIC50 and MIC90 = 8 mcg/ml) was only moderately active whereas efrotomycin (MIC50 = 0.125, MIC90 = 0.25 mcg/ml) was highly active against C. difficile.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011728:Pyridones; C012954:efrotomycin; D002939:Ciprofloxacin