Synthesis and antithrombogenicity of anionic polyurethanes and heparin-bound polyurethanes.
Two kinds of novel antithrombogenic polyurethane materials were synthesized. One of them is a polyetherurethane with anionic charges on the film surface, and the other is a polyetherurethaneurea to which heparin was covalently bound. The mechanism of their antithrombogenicity was investigated. The anionic polyetherurethane selectively adsorbed albumin, did not cause a conformational change of plasma proteins adsorbed, and suppressed the adherence and deformation of platelets but did not deactivate the blood-clotting system, thus leading to a moderate antithrombogenicity. The heparin-bound polyetherurethaneurea was not favorable for the selective adsorption of albumin, caused the denaturation of plasma proteins adsorbed, and induced the adherence and deformation of platelets but deactivated the blood-clotting system, leading to excellent antithrombogenicity. For the investigation of blood-material interaction, the importance of a multiparameter estimation of the activation of platelets and the blood-clotting system was indicated.
D000327:Adsorption; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D005343:Fibrinolytic Agents / Q000138:chemical synthesis*; D006493:Heparin; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000494:pharmacology; D011485:Protein Binding; D013499:Surface Properties; D013918:Thrombin Time
D005343:Fibrinolytic Agents; D011140:Polyurethanes; C115016:polyetherurethane; D006493:Heparin; C044690:polyetherurethane urea