Haematological abnormalities in mice continuously exposed to ethanol vapour.
Mice exposed to high concentrations of ethanol vapour (25-38 mg/l of inhaled air) for 24 h develop leucopenia, neutropenia, lymphopenia, monocytopenia and thrombocytopenia but not anaemia or macrocytosis. Their bone marrows usually give normal deoxyuridine-suppressed values and contain normal numbers of granulocyte-macrophage progenitor cells and slightly reduced numbers of megakaryocytes. Mice exposed to lower concentrations of ethanol vapour (10-25 mg/l of inhaled air) for 20-43 days develop thrombocytopenia only and, like the mice exposed for 24 h, do not develop anaemia or macrocytosis. The bone marrows of mice exposed to ethanol for 24 h or for 20-43 days, did not show either megaloblastic or sideroblastic erythropoiesis. The data suggest that the ethanol-treated mouse may provide a useful model for the investigation of the mechanisms underlying some but not all of the ethanol-induced haematological changes seen in humans.
D000079:Acetaldehyde / Q000633:toxicity; D000435:Alcoholic Intoxication / Q000097:blood / Q000473:pathology; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced*; D051379:Mice; D008810:Mice, Inbred C57BL; D010976:Platelet Count; D013921:Thrombocytopenia / Q000139:chemically induced*; D014835:Volatilization
D000431:Ethanol; D000079:Acetaldehyde