Dynamic imaging of the compliant perfusion of the lungs.
A method for the study of the dynamics of the perfusion of the compliant vascular tree of the lungs using in vivo labelled 99mTc red cells and ECG gating is presented. Following blood pool labelling, posterior, ECG gated gamma camera images were acquired in time intervals of about 40 ms for 1,000-2,000 cardiac cycles. The images show the lungs plus the heart and great vessels. The image sequence containing the periodic variation of the blood activity in the lungs during the cardiac cycle is analyzed to obtain volume curves and functional images of the amplitude and phase of the lung perfusion. The interference of the heart and great vessels with the left lung can be avoided by excluding the superimposed areas in the ROIs with the sacrifice of part of the left lung. This technique allows dynamic visualization of the perfusion process in the compliant arterial and venous vascular trees of the lungs. The results obtained with this method in normals and some pathologies are discussed.
D004562:Electrocardiography; D001330:Electronic Data Processing; D005583:Fourier Analysis; D006321:Heart / Q000502:physiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology; D008170:Lung Compliance; D008171:Lung Diseases / Q000000981:diagnostic imaging; D008954:Models, Biological; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging