Parkinson's disease and dementia: norepinephrine and dopamine in locus ceruleus.
Norepinephrine, 3-methoxy 4-hydroxyphenylethyleneglycol and homovanillic acid levels were similar in the locus ceruleus of 13 controls and 8 parkinsonian patients with no intellectual deterioration, but were decreased in 7 demented patients. The concentration of dopamine was similarly diminished in non-demented and demented parkinsonians, and binding of 3H-desmethylimipramine and 3H-rauwolscine was not abnormal in parkinsonians. These data indicate that norepinephrine metabolism in the locus ceruleus is subnormal only in demented parkinsonians.
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism; D003704:Dementia / Q000378:metabolism*; D003891:Desipramine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D008125:Locus Coeruleus / Q000378:metabolism*; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism*; D015016:Yohimbine / Q000378:metabolism
D015016:Yohimbine; D008734:Methoxyhydroxyphenylglycol; D003891:Desipramine; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid