Pharmacokinetics of rifampin given as a single oral dose in foals.
Six foals from 6 to 8 weeks of age were given a single oral dose of rifampin at a dosage of 10 mg/kg of body weight. Serum rifampin concentrations were measured serially during a 24-hour period. The mean peak serum rifampin concentration was 6.7 micrograms/ml at 4 hours after treatment. The concentration decreased slowly, and at 24 hours the mean value was 2.7 micrograms/ml. The elimination half-life was 17.5 hours, and the elimination rate constant was 0.04/hr.
D000284:Administration, Oral; D000818:Animals; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D007700:Kinetics; D012293:Rifampin / Q000008:administration & dosage / Q000378:metabolism*
D012293:Rifampin