title: Reversal of coagulopathy in Kasabach-Merritt syndrome with tranexamic acid.
abstract: An infant with a giant cavernous haemangioma developed a severe consumption coagulopathy and systemic bleeding. Replacement therapy with cryoprecipitate produced only a transient improvement in the abnormal clotting, but the addition of tranexamic acid resulted in sustained correction, permitting corrective surgery to be performed.
mesh_terms: D000347:Afibrinogenemia / Q000151:congenital / Q000188:drug therapy*; D001778:Blood Coagulation Disorders / Q000151:congenital / Q000188:drug therapy*; D002081:Buttocks; D003131:Combined Modality Therapy; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005340:Fibrinogen / Q000008:administration & dosage; D006392:Hemangioma, Cavernous / Q000097:blood* / Q000151:congenital / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012983:Soft Tissue Neoplasms / Q000097:blood* / Q000151:congenital / Q000601:surgery; D013577:Syndrome; D013921:Thrombocytopenia / Q000151:congenital; D014148:Tranexamic Acid / Q000627:therapeutic use*
chemical_list: D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D005340:Fibrinogen