[Use of the polyamine test in the joint administration of 5-fluorouracil and indomethacin in stomach cancer patients].
Excretion of polyamines (spermine, spermidine and putrescine) with the urine was studied in patients with carcinoma of the stomach of the III-IV stage after intravenous injection of 5-fluorouracil and indomethacin. A 40% increase of the polyamine level in the urine was observed at the beginning and towards the end of drug infusion course as well as a decrease of these indices at the top point of chemotherapy and towards the end of it. It is emphasized that an increase of the polyamine amount following the separate use of 5-fluorouracil is less expressed than following combined use of 5-fluorouracil and indomethacin.
D000328:Adult; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D008875:Middle Aged; D011073:Polyamines / Q000652:urine*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000652:urine; D013997:Time Factors
D011073:Polyamines; D005472:Fluorouracil; D007213:Indomethacin
Ispol'zovanie poliamonovogo testa pri sovmestnom vvedenii 5-ftoruratsila i indometatsina u bol'nykh rakom zheludka.