title: [Corneal contact time of artificial tear solutions].
abstract: In 30 subjects without ophthalmological disease the corneal contact time of a new artificial polyacrylic-based tear gel (Vidisic, produced by Dr. Mann, Berlin) was compared with a well-known artificial polyvinyl alcohol-based tear solution. The Vidisic concentration remained in the corneal tear film 7 times longer than the substance it was compared with. In a second study including 7 normal subjects and 5 patients with keratoconjunctivitis sicca, the influence of Vidisic on break-up time (BUT) and the Schirmer test was demonstrated. It was found that tear secretion improved for 2-4 hours (Schirmer test) and the stability of the tear film (BUT) improved for about 6 hours with Vidisic. These results suggest that application of Vidisic four times a day is sufficient for efficatious therapy even in cases of severe keratoconjunctivitis sicca.
mesh_terms: D000179:Acrylates / Q000378:metabolism*; D003315:Cornea / Q000378:metabolism*; D005260:Female; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011142:Polyvinyl Alcohol / Q000378:metabolism; D013501:Surface-Active Agents / Q000378:metabolism*; D013666:Tears / Q000378:metabolism; D014906:Wetting Agents / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000179:Acrylates; D009883:Ophthalmic Solutions; D013501:Surface-Active Agents; D014906:Wetting Agents; C049065:vidisic; D011142:Polyvinyl Alcohol
vernacular_title: Untersuchungen zur Verweildauer von Tränenersatzmitteln.