Viscoelasticity of tracheobronchial secretions in high-frequency ventilation.
The effects of high-frequency ventilation (HFV) on the rheological properties of tracheobronchial secretions were investigated in vitro. The mucus was obtained by suction from 16 patients after major surgery of the larynx or hypopharynx. After short centrifugation, the mucus was treated with high-frequency vibrations of 3 or 30 Hz for 10 min in a chamber saturated with water vapor. The mucus was separated by a nonpermeable membrane from the ventilator's gas stream. Maximal, minimal, and mean viscosity were determined by a modified capillary viscosimeter. Under high-frequency vibrations, maximal, minimal, and mean viscosity slightly increased (p less than or equal to .001). Conversely, the mean viscosity of control samples did not change significantly. These findings indicate that high-frequency vibrations do not improve mucous rheology. Observed beneficial effects of HFV on mucociliary clearance may be caused by changes in the mucous subphase during HFV.
D001980:Bronchi / Q000502:physiology*; D004548:Elasticity; D006801:Humans; D009093:Mucus / Q000502:physiology*; D012121:Respiration, Artificial / Q000379:methods; D014132:Trachea / Q000502:physiology*; D014732:Vibration; D014783:Viscosity