title: Generalization of the Fahraeus principle for microvessel networks.
abstract: Microvessel hematocrits and diameters were determined in each vessel segment between bifurcations of three complete microvascular networks in rat mesentery. Classification of the segments as arteriolar, venular, or arteriovenular (av) was based on flow direction at branch points. Photographic and videomicroscopic mapping was used to obtain quantitative information on the architecture and topology of the networks. This topological information allowed the analysis of hematocrit distribution within a series of consecutive-flow cross sections, each of which carried the total flow through the network. The observed reduction of mean hematocrit in the more peripheral cross sections is explained by the presence of a "vessel" and a "network" Fahraeus effect. The vessel Fahraeus effect results from velocity difference between red cells and blood within the individual vessel segments due to the existing velocity and cell concentration profiles. The network Fahraeus effect is based on the velocity difference of red cells and blood caused by velocity and hematocrit heterogeneity between the vessels constituting any of the complete-flow cross sections. The network Fahraeus effect is found to account for approximately 20% of the total hematocrit reduction and increases toward the most distal cross sections.
mesh_terms: D000818:Animals; D006400:Hematocrit; D008297:Male; D008638:Mesenteric Arteries / Q000502:physiology; D008642:Mesenteric Veins / Q000502:physiology; D008833:Microcirculation / Q000502:physiology*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains