Anti-inflammatory activity of 6MFA, a compound obtained from fungus Aspergillus ochraceus.
6MFA, an interferon-inducing substance obtained from fungus, Aspergillus ochraceus, has shown anti-inflammatory activity both in acute and chronic animal models of inflammation. It was found that 6MFA was equally effective in inhibiting both exudative as well as granulative phase of inflammation. The compound suppressed also cellular migration during inflammatory process and potentiated significantly the anti-inflammatory activity of indomethacin. The compound was devoid of analgesic or antipyretic activity. The probable mechanism of action of this compound is not fully understood. However, the possibility of triggering the induction of endogenous anti-inflammatory substance(s) along with interferon(s), or interaction of induced interferon(s) directly or indirectly with the prostaglandin system has been attributed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D001230:Aspergillus / Q000032:analysis*; D004195:Disease Models, Animal; D004487:Edema / Q000517:prevention & control; D005656:Fungal Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D006099:Granuloma / Q000517:prevention & control; D006168:Guinea Pigs; D007369:Interferon Inducers / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051381:Rats
D000893:Anti-Inflammatory Agents; D005656:Fungal Proteins; D007369:Interferon Inducers; C008524:MFA 6 extract, Aspergillus ochraceus