title: Use of macrophage inhibition factor and mast-cell degranulation tests for diagnosis of cloxacillin-induced cholestasis.
abstract: Cloxacillin-induced cholestasis was diagnosed with the help of the macrophage inhibition factor and mast-cell degranulation tests. The simultaneous occurrence of both immediate type as well as cell-mediated hypersensitivity to the drug suggested that a defect in the histamine-induced suppressor cells may underly this cloxacillin-induced allergic reaction.
mesh_terms: D002464:Cell Migration Inhibition; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis; D003023:Cloxacillin / Q000009:adverse effects*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D008875:Middle Aged
chemical_list: D003023:Cloxacillin