Responses of preoptic thermosensitive neurons to poikilothermia-inducing peptides--bombesin and neurotensin.
Microelectrophoretic application of bombesin (BS) and neurotensin (NT) to thermosensitive and non-thermosensitive neurons in the preoptic and anterior hypothalamus (PO/AH) of anesthetized rats depressed the activity of 78 (54.2%) of 144 neurons and that of 66 (51.6%) of 128 neurons, respectively. The depressing effects of both peptides which were uniformly observed across warm-sensitive and cold-sensitive neurons in the PO/AH are consistent with their poikilothermic actions.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D011301:Preoptic Area / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D009496:Neurotensin; D001839:Bombesin