title: Micromotility meter: an instrument designed to evaluate the action of drugs on motility of larval and adult nematodes.
abstract: An instrument for measuring the motility of larval and adult nematodes is described along with an analysis of its use as a tool to analyse drug action on these parasites. Motility was detected from larval parasites of Nippostrongylus brasiliensis and Ascaris suum in the absence and presence of various anti-nematodal drugs. These agents produced, within 48 h, a significant decrease in larval parasite motility. The instrument was also capable of detecting the motility of Caenorhabditis elegans, adult female Brugia pahangi and their response to anti-nematodal drugs. The design of the instrument allows us to accurately measure motility in a single sample within 60 sec.
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D001200:Ascaris / Q000187:drug effects / Q000502:physiology; D002009:Brugia / Q000187:drug effects / Q000502:physiology; D002107:Caenorhabditis / Q000187:drug effects / Q000502:physiology; D005260:Female; D007559:Ivermectin / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D009068:Movement / Q000187:drug effects; D009348:Nematoda / Q000187:drug effects* / Q000502:physiology; D009559:Nippostrongylus / Q000187:drug effects / Q000502:physiology; D010274:Parasitology / Q000295:instrumentation
chemical_list: D000969:Antinematodal Agents; D007559:Ivermectin