Unilateral, intranigral infusions of amphetamine produce differential, bilateral changes in unit activity and extracellular levels of ascorbate in the neostriatum of the rat.
Simultaneous recordings of single-unit activity and oxidation current were obtained bilaterally from the neostriatum of rats in response to a unilateral infusion of D-amphetamine (2.0 microliters of 10 micrograms/microliter) into the substantia nigra. Whereas neuronal activity increases ipsilaterally and decreases contralaterally, the electrochemical signals, which reflect extracellular ascorbate, increase bilaterally. In each case, changes in unit activity precede the change in ascorbate release. Systemic administration of haloperidol (0.2 mg/kg) blocks the increase in oxidation current bilaterally, but reverses the neuronal activity response only on the ipsilateral side. These results lend further support to the view that intranigral amphetamine facilitates neostriatal ascorbate release, but this effect is not correlated with changes in single-unit activity.
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis*; D003342:Corpus Striatum / Q000032:analysis*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*
D006220:Haloperidol; D001205:Ascorbic Acid; D003913:Dextroamphetamine