Effect of background correction on left ventricular ejection fraction calculation through analysis of a simple cardiac model.
The dependence of the left ventricular ejection fraction calculation on the background correction in gated cardiac blood pool studies is examined by analyzing a simple cardiac model. It is shown that the ejection fraction is relatively insensitive to the background correction when an accurately determined variable region of interest is used, but that with a fixed region of interest the background correction must be accurately estimated. A similar ejection fraction-background correction relationship is obtained in the analysis of clinical cardiac data. Based on the cardiac model, two methods are suggested which, with further investigation and refinement, may lead to a more accurate and consistent technique for determining ejection fraction and background.
D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008955:Models, Cardiovascular; D008961:Models, Structural; D011877:Radionuclide Imaging; D013318:Stroke Volume