title: Androstane derivative devoid of anabolic-virilizing effects and endowed with an antiglucocorticoid activity.
abstract: 2-Carbodecyloxy-17 alpha-methylandrosta-1,4-dien-11 beta,17 beta-dihydroxy-3-one (decylroxibolone, BR 917) is a new androstane derivative, esterified with decyl alcohol, carrying a methyl group in the 17 position, a hydroxyl group in the 11 beta position and a carboxyl group in position 2. Unlike norandrostenolone decanoate, decylroxibolone did not cause any weight increase of the levator ani muscle and of the seminal vesicles in castrated rats, nevertheless exerting a marked antiglucocorticoid activity. This new steroid agent can consequently act positively on the nitrogen metabolism, being concurrently devoid of undesired virilizing anabolic effect.
mesh_terms: D000311:Adrenal Glands / Q000254:growth & development; D045930:Anabolic Agents; D000731:Androstanes / Q000494:pharmacology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D008297:Male; D024510:Muscle Development; D009584:Nitrogen / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000254:growth & development; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D045930:Anabolic Agents; D000731:Androstanes; D005938:Glucocorticoids; D009584:Nitrogen