[Comparative assessment of the neurovirulence of vaccinal strains of the rabies virus].
Neurovirulence of three vaccine strains of rabies virus ("Moscow", "Vnukovo-32", and "MIVP-74") was studied in mice using pathomorphology data. After intracerebral inoculations changes in the CNS were similar. The presence and the degree of the involvement of the Ammon horn is the main indicator of the infectious activity of the strain. The disease and death of the animals after inoculation with an attenuated strain may be due to the damage of intermediate neurons of descending projection tracts of the brain stem and cerebellum. Differences between strains in neurovirulence were most clearly observed after peripheral inoculation, when the "MIVP-74" strain, unlike the other two, proved to be apathogenic. Neurovirulent properties should be evaluated by characteristics of the CNS pathomorphology after intracerebral and peripheral inoculations.
D000818:Animals; D001921:Brain / Q000473:pathology; D051379:Mice; D009474:Neurons / Q000473:pathology; D011818:Rabies / Q000382:microbiology / Q000473:pathology; D011819:Rabies Vaccines; D011820:Rabies virus / Q000472:pathogenicity*; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors; D014774:Virulence; D014776:Virus Cultivation
D011819:Rabies Vaccines
Sravnitel'naia otsenka neĭrovirulentnosti vaktsinnykh shtammov virusa beshenstva.