title: Changes in the proportions of histone H1 subtypes in brain cortical neurons.
abstract: Histone H1(0) is found in tissues with little or no cellular proliferation and has been shown to accumulate during cellular terminal differentiation. Two subtypes of H1(0), H1 a and H1 b, are present in any tissue where the protein has been detected. We report here the first evidence of an age-dependent change in the proportions of H1 subtypes. In rat cerebral cortex neurons the proportion of H1 a rises from 44% of total H1 at birth to about 80% at day 300. These results show that terminally differentiated neurons synthesize and exchange H1 at a significant rate.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D002540:Cerebral Cortex / Q000254:growth & development*; D006657:Histones / Q000145:classification* / Q000302:isolation & purification; D008970:Molecular Weight; D009474:Neurons / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006657:Histones