[Infrared spectra and the molecular conformations of macrolide-group antibiotics in solution].
IR spectra (1,600-1,800, 3,100-3,700 cm-1) of tetrachlorethylene solutions of macrolide antibiotics such as erythromycin monohydrate and dihydrate, oleandomycin, erythrolose amine and anhydroerythromycin were obtained. The atoms and atomic groups included into the hydrogen bond were determined. It was shown that the antibiotic molecule conformations were stabilized by the intramolecular hydrogen bonds.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D004917:Erythromycin / Q000032:analysis; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D012996:Solutions; D004917:Erythromycin
Infrakrasnye spektry i knoformatsii molekul nekotorykh antibiotikov gruppy makrolidov v rastvore.