Benzoate and muconate, structurally dissimilar metabolites, induce expression of catA in Acinetobacter calcoaceticus.
Biosynthetic regulation of catA, the gene encoding catechol 1,2-dioxygenase (EC 1.13.1.1), was studied in an Acinetobacter calcoaceticus mutant strain unable to metabolize benzoate. Benzoate and muconate independently induced the enzyme. In glucose-grown cells, benzoate yielded higher enzyme levels than did muconate, whereas muconate was the more effective inducer in succinate-grown cells.
D000150:Acinetobacter / Q000201:enzymology / Q000235:genetics*; D001565:Benzoates / Q000494:pharmacology*; D019817:Benzoic Acid; D050548:Catechol 1,2-Dioxygenase; D049308:Dioxygenases; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D010105:Oxygenases / Q000235:genetics; D013011:Sorbic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D001565:Benzoates; D005231:Fatty Acids, Unsaturated; C005939:muconic acid; D019817:Benzoic Acid; D010105:Oxygenases; D049308:Dioxygenases; D050548:Catechol 1,2-Dioxygenase; D013011:Sorbic Acid