Rapid tumor regression and induction of tumor-regressing activity in serum by various immune-modulating agents.
A rapid decrease in the number of tumor cells from S180 tumors was caused by several antitumor polysaccharides including the beta (1-3)glucans lentinan and TAK-N and a mannoglucan MGA, but not by those lacking antitumor activity. MGA was demonstrated to induce potent tumor-regressing activity in the serum of tumor-bearing mice similar to that reported previously to be induced after an injection of CM-TAK, a carboxymethylated beta (1-3)glucan. It is probable that the induction of rapid regression of established tumors is a phenomenon common to antitumor polysaccharides and some microbiological products and that the tumor-regressing factor in the serum underlies a common mechanism.
D000818:Animals; D007167:Immunotherapy; D051379:Mice; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000097:blood / Q000276:immunology / Q000628:therapy*
D011134:Polysaccharides