Experimental documentation of presence of purinergic receptors at human atria.
Our experimental data suggest the likelihood that there is a purinergic inhibition on human atria; it appears that inhibition is mediated via P1/Ri (A-1/Ri) and P-2 receptors. Adenosine and ATP produced inhibitory effects on chronotropism and inotropism via P1/Ri (A-1/Ri) and P-2 receptors respectively.
D000241:Adenosine / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000628:Aminophylline / Q000494:pharmacology; D016275:Atrial Function; D004109:Dilazep / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D009200:Myocardial Contraction / Q000187:drug effects*; D009924:Organ Culture Techniques; D011802:Quinidine / Q000494:pharmacology; D011983:Receptors, Purinergic / Q000502:physiology*
D011983:Receptors, Purinergic; D000628:Aminophylline; D004176:Dipyridamole; D000255:Adenosine Triphosphate; D004109:Dilazep; D011802:Quinidine; D000241:Adenosine