Studies on the effects of non-steroidal and disease modifying agents on cartilage soft tissue interaction in vivo.
The present study reports the effects of certain non-steroidal anti-inflammatory (NSAID) and rheumatoid-disease-modifying drugs on a novel animal model of cartilage degradation in vivo. Air pouches were induced on the dorsal surface of rats, and femoral-head cartilage was implanted. The proteoglycan content of the implanted cartilage was then used to assess cartilage degradation. Indomethacin, D-penicillamine, levamisole and dexamethasone all have some cartilage-protective activity. These observations are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects* / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D011509:Proteoglycans / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D011509:Proteoglycans; D007978:Levamisole; D003907:Dexamethasone; D010396:Penicillamine; D007213:Indomethacin