title: Immunohistochemistry and morphometry of gastrin cells in the rat pyloric antrum during starvation.
abstract: The gastrin cells (G cells) in the rat pyloric antrum after 7, 14, 21 and 28 days of starvation were investigated by immunohistochemistry and electron microscopy. In the peroxidase anti-peroxidase method for light microscopy, gastrin immunoreactive cells during starvation markedly decreased in number and size. Quantitative electron microscopy revealed that during starvation the number of electron-lucent granules were greatly reduced, but the number of electron-dense granules increased; the number of intermediate granules were not remarkably changed in G cells. These results may suggest that the synthesis of gastrin and granule maturation were greatly inhibited during long-term starvation.
mesh_terms: D000818:Animals; D005755:Gastrins / Q000378:metabolism*; D006651:Histocytochemistry; D007120:Immunochemistry; D008297:Male; D008854:Microscopy, Electron; D011706:Pyloric Antrum / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism / Q000473:pathology*
chemical_list: D005755:Gastrins