Chick embryonic development following exposure to ethanol and pyrazole.
The mechanism of alcohol-induced dysmorphogenesis is not clear. Pyrazole is a potent inhibitor of alcohol dehydrogenase. Treatment of chick embryos at 96 h incubation with pyrazole (0.1 mg) and ethanol (0.1 ml, 40-60% v/v) enhanced the embryopathic response, compared with individual treatments. The results suggest that ethanol itself is embryotoxic.
D000818:Animals; D002642:Chick Embryo / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D011720:Pyrazoles / Q000494:pharmacology* / Q000633:toxicity
D011720:Pyrazoles; D000431:Ethanol; C031280:pyrazole