title: [Sodium oxybutyrate and piracetam acceleration of the compensatory-reparative processes after damage to the cerebral cortex in rats].
abstract: The effects of sodium hydroxybutyrate and piracetam on compensatory-reparative processes in the central nervous system have been investigated in rats after extirpation of the frontal cortex. The animals were pretrained to conditioned reflex of active avoidance. Extirpation of the frontal cortex has been shown to disturb the conditioned reflex. Sodium hydroxybutyrate (50 mg/kg) and piracetam (200 mg/kg) were found to precipitate the recovery of the damaged reflexes.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D002541:Cerebral Decortication; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D006885:Hydroxybutyrates; D011760:Pyrrolidinones; D012978:Sodium Oxybate; D010889:Piracetam
vernacular_title: Uskorenie oksibutiratom natriia i piratsetamom kompensatorno-vosstanovitel'nykh protsessov posle povrezhdeniia kory golovnogo mozga u krys.