[Enhancement by metronidazole of the antitumor effect of cyclophosphane].
In experiments on mouse tumors (sarcoma-180, Ehrlich ascites tumor and hemoblastosis La) the ability of metronidazole to enhance the antitumor chemotherapeutic action of cyclophosphane was investigated. It was shown that metronidazole (1000 mg/kg) injected 60 min before cyclophosphane administration can elicit an almost two-fold increase in its radioprotective efficiency. The chemosensitizing effect of metronidazole depends on the drug concentration and the tumor type.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004357:Drug Synergism; D008795:Metronidazole / Q000627:therapeutic use*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D003520:Cyclophosphamide
Usilenie metronidazolom protivoopukholevogo deĭstviia tsiklofosfana.