Systemic baclofen stimulates gastric motility and secretion via a central action in the rat.
Intravenous (0.5 mg kg-1) or subcutaneous (2-16 mg kg-1) administration of the gamma-aminobutyric acid (GABA) analogue baclofen resulted in a stimulation of gastric motility and secretion in the rat, anaesthetized with urethane. The motility response to subcutaneous injection was dose-related. This effect was abolished by vagotomy or atropine. There was no response to baclofen in decerebrate animals. These results indicate that systemic baclofen, probably acting at a site rostral to the brainstem, stimulates gastric motility and acid secretion by a vagally-dependent mechanism.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001418:Baclofen / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003655:Decerebrate State; D005744:Gastric Acid / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014628:Vagotomy
D001285:Atropine; D001418:Baclofen