[Amino acid composition and biological action of a peptide bioregulator from bovine k-casein].
Peptide material has been first isolated from k-casein pepsin hydrolysate. Its subcutaneous injection to hungry animals induced high amplitude (250-350 mV) and high frequency (16-20 Hz) oscillations of electrical potentials usually observed in food satiety and cholecystokinin administration. The peptide reduced respiratory and to a lesser extent heart rate. Its effect is temporary eliminated by naloxone. According to an aminogram, the peptide is a fragment of para-k-casein. A neurotropic peptide effect is connected with satiety regulation and milk consumption in the postnatal period.
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects; D002364:Caseins / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D002850:Chromatography, Gel; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D010455:Peptides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
D000596:Amino Acids; D002364:Caseins; D010455:Peptides; D009270:Naloxone
Aminokislotnyĭ sostav i biologicheskoe deĭstvie peptidnogo bioreguliatora iz korov'ego k-kazeina.