Small sample properties of some parametric bioassay estimators of the LD90.
Bioassay experiments are frequently conducted with small sample sizes, but the literature offers little comparative information for small sample sizes among the analytical procedures. A computer simulation study was performed to compare several traditional analytical procedures for estimating the LD90. These estimation procedures include probit analysis with maximum likelihood estimation, logit analysis with maximum likelihood, and minimum chi 2 estimation methods. The stimulation results indicate the conditions under which each analytical method appears most useful. Recommendations are tentatively made for minimally adequate designs for bioassay studies where an LD90 is to be estimated.
D000818:Animals; D003198:Computer Simulation; D007928:Lethal Dose 50; D014116:Toxicology