Studies on anthelmintic effects of flubendazole and mebendazole on the rat lungworm Angiostrongylus cantonensis in mice and rats.
Flubendazole and mebendazole given orally at 10 mg/kg/day 5-7 days post-infection (total 30 mg/kg) were found to eliminate 93-100% of Angiostrongylus cantonensis larvae in mice and rats. No significant difference was observed between the effects of the 2 drugs. The effectiveness of the drugs decreased with the increase in days post-infection on which medication was administered. It was found possible to treat A. cantonensis adults in rats by administering flubendazole or mebendazole at 10 mg/kg/day for 10 consecutive days. The drugs exhibited better anthelmintic efficacy in a divided dosing regimen than in a single dosing regimen.
D000801:Angiostrongylus / Q000187:drug effects*; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008681:Metastrongyloidea / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009349:Nematode Infections / Q000188:drug therapy* / Q000469:parasitology; D051381:Rats; D011919:Rats, Inbred Strains
D000969:Antinematodal Agents; D008463:Mebendazole; C018945:flubendazole