title: Angiotensin II-sensitive neurons in the rat lateral hypothalamic area with efferent projections to the subfornical organ.
abstract: Thirteen neurons in the lateral hypothalamic area were antidromically activated by electrical stimulation of the subfornical organ in the rat. The activity of almost all identified neurons (N = 11) was excited by microiontophoretically applied angiotensin II. On the other hand, of the antidromically unidentified lateral hypothalamic area neurons (N = 10) tested, 4 were excited by microiontophoretically applied angiotension II and 6 were not affected. The excitatory responses of identified and unidentified lateral hypothalamic area neurons to angiotensin II were blocked by microiontophoretically applied saralasin, an angiotensin II antagonist.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D007026:Hypothalamic Area, Lateral / Q000187:drug effects*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013356:Subfornical Organ / Q000187:drug effects*
chemical_list: D000804:Angiotensin II