The teratogenic potential in rats and rabbits of D & C Yellow No. 8.
The teratogenic potential of D & C Yellow No. 8, sodium fluorescein (C.I. No. 45350, CAS No. 518-47-8) was determined in rats and rabbits. An aqueous solution of the dye was administered by gavage to groups of 25 Charles River Sprague-Dawley rats at doses of 100, 500 and 1500 mg/kg on days 6-19 of gestation and to groups of 14 Dutch Belted rabbits at doses of 30, 100 and 250 mg/kg on days 6-27 of gestation. These doses did not result in evidence of maternal toxicity or adverse effects on foetal development.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000633:toxicity*; D005865:Gestational Age; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens
D005452:Fluoresceins; D013723:Teratogens; D019793:Fluorescein