[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone].
GR mouse mammary tumour growth is stimulated by simultaneous administration of progesterone and estrone. These hormones strongly activate cAMP-dependent protein kinases both in the cytosol and in humour cell nuclei by causing the elevation of PK-1 and PK-2 activities. Ovarian hormone action on the proliferation is similar to that of growth factors, i.e., the hormones significantly stimulate the calcium-activated, phospholipid-dependent protein kinase C. Protein kinase C has been discovered is growing tumour cell nuclei. In early periods after ovarian hormone administration protein kinase C is activated in a greater degree as compared to cAMP-dependent protein kinases. A hypothesis on the feasibility of simultaneous activation by steroid hormones of both second messenger systems, namely the cAMP system and the system of production of diacylglycerol from phosphtidylinositol diphosphate is proposed.
D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009376:Neoplasms, Hormone-Dependent / Q000201:enzymology* / Q000473:pathology; D011374:Progesterone / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*
D004970:Estrone; D011374:Progesterone; D011494:Protein Kinases; D011493:Protein Kinase C
Aktivatsiia proteinkinazy C i cAMP-zavisimykh proteinkinaz v gormonzavisimykh opukholiakh molochnykh zhelez pri stimuliatsii ikh rosta progesteronom i éstronom.