Opposite effects of adrenaline and ouabain on the resting potential of rat atrial cells.
In the left rat atrium changes in diastolic potential (E max) evoked by sudden stimulation train were modified by adrenaline and ouabain. The early stimulation depolarization phase (SDP) of E max occurring on stimulation was shortened by adrenaline, but lengthened and strongly enhanced by ouabain. The stimulation repolarization phase (SRP) following SDP was markedly inhibited by ouabain, while accelerated and increased by adrenaline. In continuously stimulated atria E max was decreased by ouabain and augmented by adrenaline. The adrenaline-induced hyperpolarization was reduced or suppressed in the presence of 10-4 M or 10-3 M ouabain, respectively. The present data suggest that adrenaline could stimulate the electrogenic sodium pump in the rat atrium.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D004594:Electrophysiology; D004837:Epinephrine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010042:Ouabain; D004837:Epinephrine