Renal effects of dichloroacetate in vivo.
We have investigated the effect of dichloroacetate (DCA) on the urinary excretion of lactate and pyruvate in a patient with congenital lactic acidosis and in healthy human controls. DCA administered orally in doses of 50 mg/kg and 30 mg/kg decreased plasma lactate and pyruvate of both the patient and the controls, while the urinary excretion of lactate and pyruvate was increased. However, these urinary increments were too small to contribute to the decrease of plasma lactate and pyruvate.
D000085:Acetates / Q000494:pharmacology*; D000140:Acidosis, Lactic / Q000151:congenital / Q000652:urine; D000284:Administration, Oral; D002675:Child, Preschool; D003999:Dichloroacetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007773:Lactates / Q000652:urine; D019344:Lactic Acid; D008297:Male; D011773:Pyruvates / Q000652:urine; D019289:Pyruvic Acid
D000085:Acetates; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D003999:Dichloroacetic Acid