title: The influence of intracerebroventricular infusions on osmotically induced urine excretion in the pigeon (Columba livia).
abstract: This study deals with the influence of intracerebroventricular (ICV) infusions on urine volume and electrolyte excretion in response to a peripherally administered osmotic load in conscious behaving pigeons. The ICV infusions were intended to influence the cerebrospinal fluid (CSF) sodium (Na+) concentration that would have been increased by the hypertonic NaCl or sucrose solutions infused intravenously (IV). Urine and electrolyte excretion following IV infusion of 0.5 M NaCl were enhanced by simultaneous ICV infusion of 0.3 M NaCl and essentially unchanged by ICV infusions of 0.3 M or 0.9 M sucrose, or water. Infusions (ICV) of water, isotonic and hypertonic NaCl or sucrose did not significantly influence urine and electrolyte excretions following IV infusion of 1.0 M NaCl or sucrose (except K+ in the case of ICV/IV sucrose). Isotonic (0.3 M) or hypertonic (0.9 M) sucrose infused ICV enhanced urine and electrolyte excretion following IV infusion of 1.5 M sucrose. Similar amounts of sodium were excreted following IV infusion of 0.5 M NaCl, 1.0 M sucrose or 1.5 M sucrose plus the ICV infusions. The results suggest that the concentration of Na+ in the CSF is one of the factors that play a role in urine and electrolyte excretion following IV administration of osmotic stimuli in the pigeon.
mesh_terms: D000818:Animals; D010856:Columbidae / Q000502:physiology*; D004231:Diuresis; D005260:Female; D006982:Hypertonic Solutions; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000652:urine; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012964:Sodium / Q000134:cerebrospinal fluid; D012965:Sodium Chloride / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology*; D014882:Water-Electrolyte Balance
chemical_list: D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D013395:Sucrose; D012964:Sodium; D011188:Potassium