Effects of aging on the formation of ester forms of riboflavin in the rat lens.
We studied the effects of aging on the formation of ester forms of riboflavin in the lens of rats. The formation was highest in newborn and 2-week-old rats; a sharp decrease was noted at one month, thereafter it continued to decrease gradually reaching a plateau at 3 months. In general, esterification of riboflavin was higher in female than male rats. We found that a decrease in the esterification of riboflavin with increasing age is a characteristic change in the rat lens. This finding may help to clarify the pathogenesis of senescent change in the lens.
D000375:Aging; D000818:Animals; D004951:Esterification; D005260:Female; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000096:biosynthesis
D012256:Riboflavin