[Quantitative historadioautographic analysis of the cellular proliferation characteristics of the aortic wall in rabbits with experimental atherosclerosis].
Aortic intima cell proliferation has been studied in 49 rabbits with progressing experimental hypercholesterolemia, using 3H-thymidine. It has been shown that focal cell proliferation is related to infiltration sites of apo-B lipoproteins and can be observed already at pre-lipid stage of atherogenesis. 4 types of proliferating cells involved in the formation of lipid plaques have been identified: endothelial cells, smooth muscle cells, fibroblasts and macrophages, with the latter predominating in the atherosclerotic plaque cover.
D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D001345:Autoradiography; D002455:Cell Division; D004036:Diet, Atherogenic; D006651:Histocytochemistry; D006937:Hypercholesterolemia / Q000378:metabolism / Q000473:pathology; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D011817:Rabbits; D013997:Time Factors
D008074:Lipoproteins
Gistoradioavtograficheskiĭ kolichestvennyĭ analiz osobennosteĭ proliferatsii kletok stenki aorty krolikov pri éksperimental'nom ateroskleroze.