[Effect of serum factors on the intracellular killing of Trichophyton mentagrophytes microconidia by human polymorphonuclear leukocytes].
The rate of intracellular killing of T. mentagrophytes microconidia by polymorphonuclear leucocytes (PMNL) was investigated in 35 patients with anamnestic or actually present tinea infections under various conditions: in autologous serum, in serum of healthy controls, and in heat-inactivated serum. If the PMNL were incubated in serum from "immunologically experienced" persons, we found acceleration of the intracellular killing rate. Differences regarding killing rates were seen in the first hour of incubation (13 +/- 7.7% against 1 +/- 0.8%), becoming even more pronounced after heat-inactivation of the serum. Absorption of the patient's serum with T. mentagrophytes microconidia markedly reduced the rate of intracellular killing during the first hour of incubation, whereas microconidia pre-incubated in patients serum were readily killed even if a negative control serum was present.
D000328:Adult; D001798:Blood Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D014005:Tinea / Q000276:immunology*; D014249:Trichophyton / Q000276:immunology*
D001798:Blood Proteins
Einfluss von Serumfaktoren auf die intrazelluläre Abtötung von Trichophyton mentagrophytes Mikrokonidien durch menschliche polymorphkernige Neutrophile.