Effect of zinc pyridinethione on the tissue disposition of nickel and cadmium in mice.
Oral administration of zinc pyridinethione together with 63Ni2+ or 109Cd2+ to mice resulted in increased levels of these metals in several tissues in comparison with animals given the metals alone. The disposition of the 63Ni2+ was affected more than the disposition of the 109Cd2+. Increased urinary excretion of the metals was also induced by the zinc pyridinethione. Determinations of chloroform:water partition coefficients showed that lipophilic complexes are formed at equilibrations between Ni2+ or Cd2+ and zinc pyridinethione. A facilitated penetration of the lipophilic metal complexes through the cellular membranes in the gastrointestinal tract and in other tissues is probably important for the observed results. Our data suggest that effects on the disposition of metals may play a role for the toxicity of zinc pyridinethione.
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D009532:Nickel / Q000378:metabolism*; D009942:Organometallic Compounds; D011725:Pyridines / Q000494:pharmacology*; D012995:Solubility; D014018:Tissue Distribution; D015032:Zinc / Q000494:pharmacology*
D009942:Organometallic Compounds; D011725:Pyridines; D002104:Cadmium; D009532:Nickel; D015032:Zinc; C010423:pyrithione zinc