[Resonance nature of the relation of mouse survival to the interval between administrations of the S-specific agent--hydroxyurea].
The dependence of murine survival on the intervals between periodic hydroxyurea (HU) injections was studied. The single dose of HU comprised 250 mg per kg. Intervals between injections varied from 5 to 19 hours while their number changed from 6 to 9 in different experiments. A resonant increase in the survival was observed under HU administered every 8-9 or 16 1/2 hours.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006918:Hydroxyurea / Q000008:administration & dosage / Q000633:toxicity*; D007399:Interphase; D051379:Mice; D013997:Time Factors
D000970:Antineoplastic Agents; D006918:Hydroxyurea
Rezonansnyĭ kharakter zavisimosti vyzhivaemosti mysheĭ ot intervala mezhdu vvedeniiami S-fazospetsificheskogo agenta--oksimocheviny.