Epoxydicarboxylic aciduria resulting from the ingestion of castor oil.
A woman who was investigated because of suspected malabsorption was found to excrete large amounts of 3,6-epoxyoctanedioic, 3,6-epoxydecanedioic and 3,6-epoxydodecanedioic acids. The origin of these compounds could be traced to the factitious ingestion of castor oil. Healthy subjects and conventional as well as germ-free rats also excrete these substances after ingestion of castor oil. The epoxydicarboxylic acids are thus endogenous metabolites from ricinoleic acid. The shortest of the three homologues is present in small amounts in normal urine. It may be formed by cyclization of a hydroxylated beta-oxidation intermediate.
D000818:Animals; D002368:Castor Oil / Q000009:adverse effects*; D002849:Chromatography, Gas; D003998:Dicarboxylic Acids / Q000652:urine*; D004852:Epoxy Compounds / Q000652:urine; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D008875:Middle Aged; D051381:Rats; D012277:Ricinoleic Acids / Q000378:metabolism
D003998:Dicarboxylic Acids; D004852:Epoxy Compounds; D012277:Ricinoleic Acids; D002368:Castor Oil; C030521:ricinoleic acid