[Assessment of the reproductive function of white rats exposed to cephalexin by inhalation].
The embryotoxic and teratogenic effects of cefalexin were studied on Wistar albino rats subjected to inhalations of the antibiotic within the whole gravidity term. It was shown that in a concentration of 1.29 mg/m3 cefalexin did not increase the rate of fetus intrauterine death, had no unfavourable effect on the fetus and placenta development and did not induce anomalies in development of the fetus internal organs. The frequency of sensitization in the gravid and nongravid animals was the same. No signs of sensitization were detected in the litter of the rats treated with cefalexin inhalations.
D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002506:Cephalexin / Q000378:metabolism / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*
D002506:Cephalexin
Otsenka sostoianiia reproduktivnoĭ funktsii belykh krys pri ingaliatsionnom vozdeĭstvii tsefaleksinom.