[Acriflavine binding and DNA stability].
The influence of acriflavine in the process of exposing DNA solution to gamma-radiation is studied. Acriflavine being actively bound to DNA is demonstrated not to protect DNA molecule from radiation damage. No radiation-induced variation in acriflavine-DNA binding degree is discovered. Acriflavine protective properties are revealed when the concentration of acriflavine is essentially high. This confirms our early results according to which only free ligands in solution protect DNA from radiation damage.
D000167:Acriflavine / Q000378:metabolism*; D000609:Aminoacridines / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism* / Q000528:radiation effects; D004249:DNA Damage; D005720:Gamma Rays; D066298:In Vitro Techniques; D008024:Ligands; D014783:Viscosity
D000609:Aminoacridines; D008024:Ligands; D000167:Acriflavine; D004247:DNA
Sviazyvanie akriflavina i stabil'nost' DNK.