title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in the environment: human health risk estimation and its application to the Seveso case as an example.
abstract: Findings from selected dose-response experimental studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) carcinogenic action in rodents were utilized for low-dose lifetime cancer risk estimation in man. The Weibull, Armitage-Doll, and linearized Armitage-Doll mathematical models were employed in this work. Conversion factors, based on body surface, of 1/5 and 1/11 were also employed for rat- and mouse-to-man extrapolation. Conservative estimates from the linearized Armitage-Doll upper 99% confidence limit associate a 10(-5) risk probability level to TCDD daily doses of 0.15-2.4 pg/kg body wt., while levels of 10(-6) and 10(-7) are associated with uptakes 10- and 100-fold lower, respectively. Based on environmental microanalytical records, exposure to TCDD of Seveso (Milan, Italy) Zone B and R inhabitants was calculated from 0.5 year after the accident onward. Exposure through food produced locally was assumed to be zero. The lifetime cancer risk for the considered cohort at the highest exposure does not appear to exceed 10(-5).
mesh_terms: D000818:Animals; D004147:Dioxins / Q000032:analysis*; D004781:Environmental Exposure; D006801:Humans; D007558:Italy; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis* / Q000633:toxicity; D051381:Rats; D012306:Risk; D012989:Soil Pollutants / Q000032:analysis / Q000633:toxicity
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants