Peroral glucose tolerance test. Relation to skeletal muscle electrolytes.
Seventy patients on long-term diuretic therapy for arterial hypertension and/or congestive heart failure were investigated with regard to skeletal muscle electrolytes and the results of a peroral glucose tolerance test. A significant correlation was observed between the muscle content of potassium and the ability to handle a glucose load. Thirty patients underwent a second set of samples six months after the first one, 23 of whom had a reduction of their muscle potassium content relative to the first biopsy. They simultaneously demonstrated a significant impairment of glucose tolerance.
D004232:Diuretics / Q000009:adverse effects; D005260:Female; D005951:Glucose Tolerance Test; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012965:Sodium Chloride / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D004232:Diuretics; D012965:Sodium Chloride; D008274:Magnesium; D011188:Potassium