title: Alternatives for potency testing of veterinary vaccines: rabies vaccine as a model.
abstract: Optimum information about potency of a vaccine is achieved by a protection test on the target animal species. However, application of this procedure to routine batch control requires a great number of target animals. In order to reduce the number of such animals, laboratory animal tests or in vitro tests have to be established. These tests must be correlated to target animal protection tests allowing the estimation of the vaccine potency with the same accuracy. With respect to testing the potency of rabies vaccines, alternatives are discussed, i.e. the mouse protection test, induction of antibodies in mice and in vitro tests.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D006023:Glycoproteins / Q000276:immunology; D051379:Mice; D011819:Rabies Vaccines / Q000592:standards*; D011820:Rabies virus / Q000276:immunology*; D013223:Statistics as Topic
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D006023:Glycoproteins; D011819:Rabies Vaccines