[Participation of kynurenine and its derivatives in disorders of the cardiac rhythm].
The influence of tryptophan derivatives: L-kynurenine, 3-hydroxy-DL-kynurenine, kynurenic, xanthurenic, 3-hydroxy-anthranilic and quinolinic acids has been investigated in isolated frog heart. It has been established that L-kynurenine, 3-hydroxy-DL-kynurenine, xanthurenic acid and quinolinic acid at a concentration of 10(-6)-10(-3) mol/l initiate bradycardia. In some cases xanthurenic and quinolinic acids cause a one-minute cardiac arrest in early diastole. 3-hydroxy-anthranilic acid at a concentration of 10(-5) and 5 X 10(-5) mol/l produces premature beats and attacks of tachycardia. In the experiments, using 10(-6)-10(-3) mol/l of kynurenic acid, no impairment of the cardiac rhythm was observed in the isolated frog heart.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007737:Kynurenine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000502:physiology; D011898:Ranidae
D007737:Kynurenine
Uchastie kinurenina i ego proizvodnykh v narusheniiakh serdechnogo ritma.