Elimination of brotizolam in elderly patients after multiple doses.
Plasma brotizolam levels were measured in 5 elderly patients given 0.25 mg daily. The half-life of brotizolam elimination was 6.0 h after a single dose and 6.9 h after continuous administration for 3 weeks. The brotizolam concentration in plasma 2 h after the dose was 3.5 and 3.4 ng/ml, respectively, on the first and last days of the study. Brotizolam levels measured several times during the study 10 h after dosing were between 1.2 and 1.8 ng/ml. Thus, administration of brotizolam 0.25 mg/d to elderly patients for 3 weeks led neither to its accumulation nor to faster elimination. The half-life of brotizolam elimination in elderly patients was in the upper range of that found in young volunteers.
D000368:Aged; D000369:Aged, 80 and over; D001381:Azepines / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood*; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D001381:Azepines; D006993:Hypnotics and Sedatives; C020960:brotizolam