title: [Effect of dioxadet on tumors transplanted to the brain].
abstract: A newly-developed antitumor drug Dioxadet is capable of passing the blood-brain barrier. The specific activity of rat brain tissue ranged 8-55% of that of blood at different periods after intraperitoneal injection of 14C-labelled Dioxadet. Dioxadet treatment of mice and rats bearing intracranially-transplanted L1210 leukemia and glioma 35 was followed by a 38-48 and 29% increase in survival, respectively.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary; D005910:Glioma / Q000188:drug therapy; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D051381:Rats; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines; C040269:dioxadet
vernacular_title: Vliianie dioksadéta na opukholi, perevitye v golovnoĭ mozg.