title: [Potentiation of a vitamin K antagonist by a pefloxacin-rifampicin combination].
abstract: The combination of a new quinolone, pefloxacin, with rifampicin seemed of interest in the treatment of staphylococcal osteitis. Interactions of a coumarin anticoagulant (acenocoumarol) and several antibiotics were well known, mostly resulting in a decrease of the anticoagulant activity. A new interaction of this anticoagulant drug with the pefloxacin-rifampicin combination is described which gave an increase in the anticoagulant activity.
mesh_terms: D000074:Acenocoumarol / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000074:Acenocoumarol
vernacular_title: Potentialisation d'une antivitamine K par l'association péfloxacine-rifampicine.