The effect of gold salts on casein-induced macrophage activation and serum amyloid protein SAA levels.
Previous work from our laboratory has demonstrated a marked inhibitory activity of Auranofin (Au) and Gold Sodium Aurothiomalate (GST) on monocyte-macrophage function and an important role for macrophages in the pathogenesis of casein-induced experimental amyloidosis. In the present study we have looked at the in vivo effect of Au and GST on the inhibition of casein-induced macrophage activation and serum SAA levels. Au and GST markedly inhibited casein-induced macrophage activation while only Au reduced serum SAA levels to a significant degree. The present data raises the possibility that Au may be helpful in the treatment of secondary amyloid disease.
D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003176:Complement C3 / Q000378:metabolism; D006046:Gold / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D011961:Receptors, Fc / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000097:blood*
D002364:Caseins; D003176:Complement C3; D011961:Receptors, Fc; D000685:Serum Amyloid A Protein; D006046:Gold