Experimental study on drug therapy of "traction retinal detachment" after posterior penetrating eye injury in the rabbit.
In an experimental study on rabbits, a standardized eye injury was created by using the "pars-plana incision model." Subsequently, the effect of intravenous application of dexamethasone and penicillamine on traction retinal detachment was investigated. The two drugs were applied in varying concentrations and combinations (single and combined use in varying intervals), followed by a 3-month control period without medication. Clinical and histological findings showed that intravitreal instillation of 1.2 mg dexamethasone reduces the incidence of retinal detachment from 46% to 27%. Higher concentrations of dexamethasone, as well as the use of penicillamine or a combination of both substances, proved to enhance traction retinal detachment.
D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D005131:Eye Injuries / Q000150:complications*; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use*; D011817:Rabbits; D012163:Retinal Detachment / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014950:Wounds, Penetrating / Q000150:complications*
D003907:Dexamethasone; D010396:Penicillamine