title: Effect of hypotension induced by sodium nitroprusside on catecholamine overflow in the canine kidney.
abstract: The overflow of noradrenaline (NA) and dopamine (DA) to plasma in the kidney in response to hypotension induced by sodium nitroprusside were studied in barbiturate-anaesthetized dogs in order to evaluate the possible existence of separately regulated renal noradrenergic and dopaminergic nerve fibres. When mean arterial blood pressure was lowered to 55 +/- 5 mmHg, arterial plasma NA, DA and adrenaline concentrations were increased and renal blood flow decreased. Renal sympathetic nerve activity was assessed by measuring the renal overflow of catecholamines to plasma. To obtain more accurate estimates of the renal contribution to catecholamines in renal venous plasma we corrected for the renal extraction of arterial catecholamines, assessed by the extraction of endogenous adrenaline. The corrected renal NA overflow to plasma increased from 164 +/- 52 to 419 +/- 137 pmol min-1 (P less than 0.05) during sodium nitroprusside induced hypotension. The renal overflow of DA to plasma was, however, not influenced significantly. The DA/NA ratio for renal venous plasma concentration as well as for renal overflow to plasma was decreased (P less than 0.05) by sodium nitroprusside induced renal nerve activation. In contrast, electrical renal nerve stimulation has previously been shown to enhance the overflows of DA and NA in parallel. One possible interpretation of these findings is that sodium nitroprusside selectively activated renal noradrenergic but not the putative dopaminergic nerve fibres while electrical stimulation activated both types of fibres.
mesh_terms: D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000097:blood*; D004558:Electric Stimulation; D005292:Ferricyanides / Q000494:pharmacology*; D007022:Hypotension / Q000503:physiopathology*; D007668:Kidney / Q000294:innervation*; D009599:Nitroprusside / Q000494:pharmacology*; D009638:Norepinephrine / Q000097:blood*; D011311:Pressoreceptors / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D012079:Renal Circulation / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000502:physiology
chemical_list: D005292:Ferricyanides; D011954:Receptors, Dopamine; D009599:Nitroprusside; D004298:Dopamine; D009638:Norepinephrine