title: Fibronectin and cryoprecipitation.
abstract: Fourteen patients with essential mixed cryoglobulinemia were studied. The relevance of fibronectin (FN) in cryoprecipitation seems to be of relative importance since only two thirds of the cryoprecipitates have a higher cryocrit level when FN is present. On the other hand, the other samples show a lower precipitating activity after plasma heating at 60 degrees C. This reduction may reflect either a structural FN modification by heating or the denaturation of other cryoprecipitating molecules. It is possible, even if not necessary, that at least in vitro FN plays a role in the cryoprecipitate formation.
mesh_terms: D000990:Antithrombin III / Q000032:analysis; D011232:Chemical Precipitation; D003080:Cold Temperature; D003449:Cryoglobulinemia / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis; D005353:Fibronectins / Q000302:isolation & purification* / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D011485:Protein Binding; D011489:Protein Denaturation
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D000990:Antithrombin III; D005340:Fibrinogen