title: Quantitative alterations in the metabolism of carbonyl compounds due to diet-induced lipid peroxidation in rats.
abstract: Following the dietary induction of lipid peroxidation in rats (verified by the levels of malonaldehyde and glutathione peroxidase), the urinary carbonyl compounds were followed chromatographically. Through a headspace gas chromatographic procedure, increases of several aldehydes and furan derivatives were noticed. Liquid chromatography of the dinitrophenylhydrazone derivatives of urinary carbonyls provided a more definitive experiment, in which the increased-peroxidation animals could be compared to those maintained on a control diet. Several carbonyl metabolites, identified by mass spectrometry, were elevated following the lipid peroxidation induction.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003500:Cyclization; D004032:Diet; D007659:Ketones / Q000652:urine*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007659:Ketones; D008054:Lipid Peroxides; D008315:Malondialdehyde