Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors.
The antitumor action of inhibitors of cyclooxygenase (indomethacin) and lipoxygenase activity (nordihydroguaiaretic acid) of arachidonic acid cascade was investigated in the chemically induced large bowel tumors in Sprague-Dawley rats. Indomethacin treatment completely prevented the carcinogenic effect of methylazoxymethanol. Thus, no tumors were found in the 14 rat test group, compared with 13 of 14 tumor-bearing rats in the untreated control group. Although nordihydroguaiaretic acid treatment does not abolish prostaglandin synthesis, it does reduce the effect of the carcinogen and tumors were found in only five of 14 treated rats. From this study it can be postulated that not only is reduction in prostaglandin formation responsible for the inhibition of tumor growth, but also leukotrienes may play some role.
D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D002396:Catechols / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use*; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009637:Masoprocol / Q000627:therapeutic use*; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives; D011448:Prostaglandin Antagonists; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D002396:Catechols; D011448:Prostaglandin Antagonists; D008746:Methylazoxymethanol Acetate; D009637:Masoprocol; C030667:methylazoxymethanol; D007213:Indomethacin