General pharmacological properties of a low molecular weight heparin in rodents.
The effects on central nervous system of a new low molecular weight heparin (OP/LMWH) were studied in mice and rats. The effect of OP/LMWH on respiration, blood pressure and heart rate was studied in guinea-pigs and rats. In these studies unfractionated heparin was used for comparison. OP/LMWH, up to 10 mg/kg/s.c., did not show any effect on central nervous system and did not increase the blood pressure, heart rate and respiration rate up to 10 mg/kg i.v. At the same dosages, heparin presented effects similar to those shown by OP/LMWH.
D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001794:Blood Pressure / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors; D012119:Respiration / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D015016:Yohimbine / Q000037:antagonists & inhibitors
D000700:Analgesics; D000927:Anticonvulsants; D015016:Yohimbine; D010095:Oxotremorine; D012110:Reserpine; D006493:Heparin