title: Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.
abstract: Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D004273:DNA, Neoplasm / Q000032:analysis; D005786:Gene Expression Regulation / Q000187:drug effects; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000235:genetics*; D009602:Nitrosamines; D009857:Oncogenes; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004273:DNA, Neoplasm; D009602:Nitrosamines; C051010:N-methyl(methoxymethyl)nitrosamine