Spermicidal effect in vitro by the active principle of garlic.
The in vitro spermicidal effect of Allitridum, an active principle of garlic, was investigated. The data showed that sperm motility was inhibited with various concentrations of Allitridum at different intervals ranging from 20 seconds-200 minutes as compared to control. An obvious immobilization of spermatozoa occurred at 7.5 mg/ml of Allitridum. The effects on sperm motility appeared to be dose-dependent.
D000498:Allyl Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013081:Sperm Motility / Q000187:drug effects*; D013089:Spermatocidal Agents; D013440:Sulfides / Q000008:administration & dosage / Q000494:pharmacology*; D014621:Vagina / Q000187:drug effects
D000498:Allyl Compounds; D013089:Spermatocidal Agents; D013440:Sulfides; C042577:diallyl trisulfide