[Changes in the catecholamine content of brain structures in rats subjected to immobilization stress].
The changes in DOPA and catecholamine (adrenaline, noradrenaline, dopamine) levels were investigated in noradrenaline- and dopamine-synthesizing brain nuclei of Wistar rats after prolonged immobilization stress on catecholamine analyzer (BAS, USA) using HPLC technique. Distinct DOPA and catecholamine changes were observed in locus ceruleus + nucleus subceruleus (1. c + n. sc) and substantia nigra at any stage after immobilization (right after immobilization and 15 and 30 days later). The most prominent alterations in noradrenaline content were detected in 1. c + n. sc. 30 days after immobilization NA level in these nuclei was 1.5 times higher, as compared to the control one. It is suggested that the increasing noradrenaline level in 1. c + n. sc. plays a defensive role in survival of rats after immobilization stress.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D007103:Immobilization; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism*
D002395:Catecholamines
Izmeneniia soderzhaniia katekholaminov v strukturakh mozga krys, perenesshikh immobilizatsionnyĭ stress.