Deferoxamine increases skin flap survival: additional evidence of free radical involvement in ischaemic flap surgery.
This study presents further evidence of free radical involvement in skin flap necrosis in a dorsal rat flap model. Rats receiving deferoxamine, a free radical scavenger and iron chelator had significantly less necrosis (p less than 0.001) than saline treated rats. In a separate experiment, tissue determinations for malonyldialdehyde (MDA) were consistent with the survival results in showing a significant decrease in MDA in all biopsy sites (p less than 0.05 or less), indicative of reduced lipoperoxidation in the deferoxamine treated rats.
D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology*; D005609:Free Radicals; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013524:Surgical Flaps; D014969:Xanthine Oxidase / Q000378:metabolism
D005609:Free Radicals; D008315:Malondialdehyde; D014969:Xanthine Oxidase; D003676:Deferoxamine