title: [Effectiveness of nitrosomethylurea derivatives in the combined chemotherapy of experimental tumors].
abstract: An antitumour activity of combined application of two nitrosomethylurea derivatives--dimethylnitrosourea and ADEKO with cytostatics of various groups was studied in transplanted tumours of La and L 1210 leukemias and Lewis lung carcinoma. A combined treatment by ADEKO with cyclophosphamide, methotrexate and dibunol resulted in therapeutic synergism evaluated by the tumour growth inhibition activity (kappa *) and by life span (delta tau) increase of tumour-bearing animals. An additive antitumour effect was established in case of a combined application of ADEKO with ftorafur, vincristine, prednisolone and dimethylnitrosourea with methotrexate.
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007942:Leukemia, Experimental / Q000188:drug therapy; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000031:analogs & derivatives; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*
chemical_list: C001049:N,N'-dimethylnitrosourea; D008770:Methylnitrosourea; C042070:ADEKO
vernacular_title: Effektivnost' proizvodnykh nitrozometilmocheviny v kombinirovannoĭ khimioterapii éksperimental'nykh opukholeĭ.