[Excretion of cis-diamminedichloro platinum (CDDP) into pancreatic juice and hepatic bile].
By means of pancreatic and biliary duct drainage in two pancreato-duodenectomized patients, excretion of CDDP into pancreatic and hepatic bile was studied. CDDP was infused at a dose of 50 mg/m2 for 40-60 min. Platinum was determined by the flameless atomic absorption spectrometric method. CDDP was excreted into pancreatic juice in the form of filterable platinum over a short duration and in a small amount. The excretion gradient into pancreatic juice was around 20%. Total output of CDDP in pancreatic juice was estimated to be 0.1% of administered platinum. Although no new observations on the urinary and biliary excretion of CDDP were obtained, it was noticed that platinum was excreted in filterable form in both urine and bile, and that the excretion gradients in each were approximately 300% and 35%, respectively, in the present study.
D001646:Bile / Q000378:metabolism*; D002945:Cisplatin / Q000378:metabolism* / Q000652:urine; D006801:Humans; D010189:Pancreatic Juice / Q000378:metabolism*; D013054:Spectrophotometry, Atomic
D002945:Cisplatin