title: Elevated blood glucose after compound 48/80 treatment is not related to hepatic mast cell degranulation in rats.
abstract: Blood glucose, hepatic glycogen, and the histological integrity of hepatic mast cells, were evaluated in anesthetized rats receiving iv injections of 0.125 mg/kg body weight compound 48/80 (a mast cell degranulator) and/or of 0.001 to 10.0 mg/kg body weight lodoxamide tromethamine (an inhibitor of mast cell degranulation). A nonglucogenic dose of lodoxamide, 0.001 mg/kg body weight, prevented dissipation of histochemically demonstrable fluorescence in mast cells (degranulation) without inhibiting compound 48/80-induced hyperglycemia and hepatic glycogenolysis. These results suggest that this glucotropic response is independent of compound 48/80-evoked release of mediators such as serotonin from mast cells.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000187:drug effects; D008099:Liver / Q000166:cytology*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000166:cytology*; D009570:Nitriles; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014325:Tromethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D008112:Liver Glycogen; D009570:Nitriles; D014325:Tromethamine; D003189:p-Methoxy-N-methylphenethylamine; C022028:lodoxamide tromethamine; D010072:Oxamic Acid