Propylthiouracil, a selective inhibitor of NADH-cytochrome b5 reductase.
Propylthiouracil inhibited the activity of NADH-cytochrome b5 reductase of rat liver microsomes using potassium ferricyanide as electron acceptor. On the other hand, NADPH-cytochrome P-450 reductase activity was not affected by the compound. NADH-supported reduction of cytochrome b5 was also inhibited by propylthiouracil in the reconstituted system consisting of cytochrome b5 and partially purified NADH-cytochrome b5 reductase.
D000818:Animals; D003579:Cytochrome Reductases / Q000037:antagonists & inhibitors*; D042966:Cytochrome-B(5) Reductase; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology*; D011441:Propylthiouracil / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011441:Propylthiouracil; D003579:Cytochrome Reductases; D042966:Cytochrome-B(5) Reductase