[The use of artificial hyperglycemia in the radiotherapy of patients with rectal cancer].
A treatment modality employing radiotherapy with subsequent hyperglycemia induction was evolved in experiments on mice and then clinically tested in 32 cases of inoperable locally--extensive primary and recurrent cancer of the rectum. A 50% regression of tumor was registered in 14 (43.0%) out of 32 patients treated with radiotherapy in combination with hyperglycemia. Similar degree of regression was observed only in 6 (15.0%) out of 40 patients who received the same radiation treatment unaccompanied by hyperglycemia. The difference was statistically significant. No untoward side--effects developed. The results are encouraging and seem to open up new vistas of clinical research.
D000230:Adenocarcinoma / Q000097:blood / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005947:Glucose; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D011838:Radiation-Sensitizing Agents; D012004:Rectal Neoplasms / Q000097:blood / Q000532:radiotherapy*
D001786:Blood Glucose; D011838:Radiation-Sensitizing Agents; D005947:Glucose
Ispol'zovanie iskusstvennoĭ giperglikemii pri luchevom lechenii bol'nykh rakom priamoĭ kishki.