[Decreased isoproterenol sensitivity of the salivary epithelium in mice with transplanted tumors].
The proliferative response of secretory cells of parotid glands to isoproterenol could not be observed in tumour-bearing mice, while in normal mice a ten-fold increase was usually observed. Mice with subcutaneous allografts of normal tissue (tail fragments) demonstrated sensitivity similar to normal mice. Apparently, a lack of sensitivity in tumour-bearing mice is characteristic of the tumour-host interaction. According to electron microscopic cytochemical data the adenylate cyclase activity is not changed in the mentioned cells of the tumour-bearing mice. It is supposed that lack of sensitivity is due to an alteration of certain properties of some other components of the beta-adrenergic system.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D004848:Epithelium / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000503:physiopathology*; D010306:Parotid Gland / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology
D011433:Propranolol; D000262:Adenylyl Cyclases; D007545:Isoproterenol
Snizhenie chuvstvitel'nosti k izoproterenolu épiteliia sliunnykh zhelez mysheĭ s perevivnymi opukholiami.