title: Corticosterone, free fatty acid and glucose responses of rats to footshock, fear, novel stimuli and instrumental reinforcement.
abstract: Rats were subjected to sessions of footshock, fear stimuli and instrumental reinforcement to assess responses of blood corticosterone, free fatty acids (FFA) and glucose. The corticosterone response to fearful situations exhibited a stimulus generalization decrement, thus demonstrating a contribution of Pavlovian classical conditioning to the activity of the hypothalamo-pituitary-adrenal system. Corticosterone levels were shown to decrease during operant sessions with large water reinforcements, while FFA and glucose levels were increasing, thus dissociating these stress measures. FFA responses to intermittent, intense footshock were found to be quadratic; blood levels of FFA increased within 10 min, decreased by 40 min, and then showed the increase with 80-min long sessions previously reported in the literature. This pattern of response was not influenced by prior food deprivation or different methods of sampling blood. Blood levels of FFA increased generally to novel/fearful situations and instrumental reinforcement sessions, which were stimulus situations less stressful than the footshock sessions. Glucose increases occurred to footshock and instrumental reinforcement sessions under some conditions, depending more than corticosterone and FFA on prior food deprivation and blood sampling method.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003216:Conditioning, Operant / Q000502:physiology; D003345:Corticosterone / Q000097:blood*; D004597:Electroshock; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005239:Fear / Q000502:physiology*; D005795:Generalization, Stimulus / Q000502:physiology; D008297:Male; D011603:Psychophysiology; D051381:Rats; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D003345:Corticosterone