The effect of chronic oral ketoconazole on in vivo drug metabolism in the rat.
To verify the potential in vivo effects of ketoconazole, an antifungal agent with a wide spectrum of activity, on liver function, caffeine and phenytoin were chosen as probes for hepatic oxidative drug metabolism. Chronic treatment with ketoconazole (80 mg/kg oral) in the rat did not affect both pharmacokinetic profile of probes and a few biochemical parameters related to liver functions. These results indicate that further specific hepatic drug-metabolizing monoxygenase activities responsible to ketoconazole are to be identified to explain ketoconazole-drug interactions reported in vivo.
D000284:Administration, Oral; D000818:Animals; D002110:Caffeine / Q000378:metabolism; D007654:Ketoconazole / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D051381:Rats
D004364:Pharmaceutical Preparations; D002110:Caffeine; D010672:Phenytoin; D007654:Ketoconazole