[Antioxidants--stabilizers of the Ca2+ transport enzyme system in sarcoplasmic reticulum membranes in vivo].
It has been demonstrated that natural and synthetic antioxidants of different chemical structures (alpha-tocopherol, butylated hydroxytoluene, 2-ethyl-6-methyl-3-hydroxypyridine) were capable of stabilizing enzymatic Ca2+ transport in sarcoplasmic membranes of the heart and skeletal muscles in vivo. Chronic administration of water-soluble antioxidant 2-ethyl-6-methyl-3-hydroxypyridine to young and old rats resulted in the increased rate of Ca2+ transport into sarcoplasmic reticulum vesicles of the heart and skeletal muscle homogenates. Keeping rats on vitamin E-rich diets supplemented with synthetic antioxidant butylated hydroxytoluene led to stabilization of Ca2+-ATPase against thermal denaturation in sarcoplasmic reticular membranes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010847:Picolines; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D010847:Picolines; D011725:Pyridines; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D002118:Calcium; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Antioksidanty--stabilizatory fermentoĭ sistemy transporta Ca2+ v membranakh sarkoplazmaticheskogo retikuluma in vivo.