Cholinergic mediation in dermorphin-induced growth hormone secretion in man.
The effects of pirenzepine (P), a cholinergic muscarinic antagonist, on growth hormone (GH) and prolactin (PRL) response to dermorphin (D) were studied in a group of 7 healthy men. D produced clear elevations in GH and PRL levels. P completely blocked the GH-releasing activity of D, whereas it did not alter the PRL-releasing activity. These results indicate that GH-releasing action of D is mediated via the central cholinergic nervous system in man.
D000328:Adult; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018847:Opioid Peptides; D010890:Pirenzepine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D011976:Receptors, Muscarinic / Q000502:physiology*
D009842:Oligopeptides; D018847:Opioid Peptides; D011976:Receptors, Muscarinic; C030058:dermorphin; D010890:Pirenzepine; D011388:Prolactin; D013006:Growth Hormone