Diplomyelia: caudal duplication of the neural tube in mice.
Diplomyelia (duplication of the neural tube or spinal cord) was studied histologically in nine cases of T/+ mouse embryos at 10-15 days of gestation. Grüneberg investigated T/+ fetuses and interpreted the extra neural tube to be notochord, but a reexamination of this material demonstrated that the interpretation is incorrect. Diplomyelia is produced in the mutations Fused, Kinky, vestigial tail, homozygous Brachyury, and t-haplotype t9 and in the new mutation, NM 529, described here.
D000818:Animals; D005865:Gestational Age; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008817:Mice, Mutant Strains; D009436:Neural Tube Defects / Q000196:embryology* / Q000235:genetics / Q000473:pathology; D009672:Notochord / Q000473:pathology; D010641:Phenotype; D013623:Tail / Q000002:abnormalities