Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota.
Eight cases of suicidal isoniazid overdose by Cambodian refugees are reviewed. In all patients generalized seizures and metabolic acidosis developed. Treatment included supportive measures and intravenous pyridoxine hydrochloride. There were no deaths. Psychiatric evaluation of each patient revealed usual and extraordinary life and social adjustment stresses. Indochinese immigrants are a subpopulation at risk for isoniazid overdose.
D000138:Acidosis / Q000139:chemically induced; D000293:Adolescent; D000328:Adult; D001213:Asian; D002160:Cambodia / Q000208:ethnology; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000378:metabolism / Q000506:poisoning*; D008016:Life Change Events; D008297:Male; D008910:Minnesota; D012640:Seizures / Q000139:chemically induced; D013406:Suicide, Attempted / Q000208:ethnology* / Q000523:psychology
D007538:Isoniazid