[The stability of hydrochlorothiazide and cyclopenthiazide in various dosage forms. 3. Stability of hydrochlorothiazide injection solutions].
Studies of the stability of hydrochlorothiazide (1) in N-methylacetamide prove that a temperature dependent equilibrium is found in the isothermic short-term test as well as in the longterm stability test. Whereas the kinetic reaction evaluation after Arrhenius doesn't allow a forecast, the 25 degrees C-values, extrapolated after the Van't Hoff-equation, were confirmed using the long-term test. By adding the decomposition product aminodisulfamide (2) the hydrolysis is restricted.
D003518:Cyclopenthiazide / Q000032:analysis*; D004232:Diuretics; D004355:Drug Stability; D006852:Hydrochlorothiazide / Q000032:analysis*; D006868:Hydrolysis; D007267:Injections; D007700:Kinetics; D049993:Sodium Chloride Symporter Inhibitors / Q000032:analysis*; D012996:Solutions
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D012996:Solutions; D006852:Hydrochlorothiazide; D003518:Cyclopenthiazide
Untersuchungen zur Stabilität von Hydrochlorothiazid und Cyclopenthiazid in unterschiedlichen Arzneiformen. 3. Mitteilung1: Stabilität von Hydrochlorothiazid-Injektionslösungen I.