[Effect of urinastatin on disseminated intravascular coagulation].
Effect of urinary enzyme inhibitor urinastatin (MTI) on disseminated intravascular coagulation (DIC) was investigated. The prolongation of PTT and increase in FDP in endotoxin-induced DIC in rats were restored by the intravenous infusion of MTI. The reduction in platelet counts, decrease in fibrinogen level and prolongation of PT were partially suppressed by the drug. Furthermore, in vitro addition of MTI prevented the decrease in r and k values and increase in ma and m epsilon values in the thromboelastogram of whole blood in endotoxin-induced DIC in rabbits. It is suggested that MTI might prevent DIC in vivo and in vitro through the inhibition of Factor XII activity and through the prevention of thromboplastin release caused by endotoxin.
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy*; D005170:Factor X / Q000032:analysis; D005174:Factor XII / Q000032:analysis; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006023:Glycoproteins / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D013916:Thrombelastography; D014361:Trypsin Inhibitors / Q000627:therapeutic use*
D005338:Fibrin Fibrinogen Degradation Products; D006023:Glycoproteins; D008070:Lipopolysaccharides; D014361:Trypsin Inhibitors; D005170:Factor X; D005174:Factor XII; C028665:urinastatin