title: Cellular changes during hypertension: a quantitative study of the rat aorta.
abstract: Using rats made hypertensive by aortic ligation or by the one kidney--one clip method, we searched the aorta for morphologic clues that could explain why hypertension aggravates atherosclerosis. Both atherosclerosis and hypertension are characterized by an increased migration of mononuclear cells into the aortic intima; we therefore quantitated this phenomenon and studied its time course. In the thoracic aorta of hypertensive rats intimal cells (emigrated mononuclear cells) increased up to 15 times 2 weeks after surgery and remained stationary thereafter. In both control and experimental rats, leukocyte emigration was heavier in the thoracic aorta than in the abdominal region. A two- to threefold increase in medial smooth muscle herniae into the intima (myointimal herniae) was also found at 8 weeks, indicating a smooth muscle cell dysfunction. Electron microscopic study of the intima showed that its thickening was due to blood-borne material and also to extracellular matrix synthesized by the endothelium. Heightened secretion reflects cell activation, a condition that (in the endothelium) leads also to leukocyte adhesion. These data suggest that, in renovascular hypertension, the aortic endothelium is in an activated state, possibly through a hormonal stimulus.
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D001013:Aorta, Thoracic / Q000032:analysis / Q000473:pathology* / Q000648:ultrastructure; D001485:Basement Membrane / Q000648:ultrastructure; D002448:Cell Adhesion; D003094:Collagen / Q000032:analysis; D004549:Elastin / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004727:Endothelium / Q000648:ultrastructure*; D005109:Extracellular Matrix / Q000648:ultrastructure; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009000:Monocytes; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D051381:Rats
chemical_list: D003094:Collagen; D004549:Elastin