Accelerated progression of diabetic nephropathy in the spontaneously hypertensive streptozotocin diabetic rat.
Streptozotocin (STZ)-diabetes was induced in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats with their litter mates serving as controls. The animals were studied for 6 months and blood pressure, weight, urinary and serum glucose, creatinine clearance, total proteinuria and albuminuria were measured monthly. With induction of diabetes, there was a significant rise in creatinine clearance in the hypertensive diabetic animals (SHR-STZ). SHR-STZ (n = 6) developed higher levels of total proteinuria than WKY-STZ (n = 5) although the rise from basal levels was only apparent after 20 weeks of diabetes. All SHR-STZ developed albustix positive proteinuria after 6 months of diabetes. In the first 12 weeks after onset of diabetes, albuminuria increased to a greater degree in SHR-STZ than in WKY-STZ. This occurred before there was a detectable rise in total proteinuria. The SHR-STZ model of genetic hypertension and diabetes may be suitable for the evaluation of antihypertensive therapy in human diabetic renal disease.
D000419:Albuminuria / Q000209:etiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology* / Q000652:urine; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology* / Q000652:urine; D008297:Male; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D001786:Blood Glucose; D003404:Creatinine