Magnesium-free medium activates seizure-like events in the rat hippocampal slice.
The effect of magnesium-free medium on the electrical activity in CA3 of the rat hippocampal slice was examined. Magnesium removal resulted in the development of spontaneous and triggered interictal-like bursting, followed by spontaneous ictal-like events and finally periodic clustered bursts. The ictal-like events consisted of a tonic firing phase and a phase of clustered burst discharges resembling the tonic and clonic phases of seizures. The return to normal medium resulted in spontaneous and triggered interictal-like bursts.
D000200:Action Potentials; D000367:Age Factors; D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000503:physiopathology*; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*
D008274:Magnesium