Salicylate-induced changes in spontaneous activity of single units in the inferior colliculus of the guinea pig.
Changes in spontaneous neuronal activity of the inferior colliculus in albino guinea pigs before and after administration of sodium salicylate were analyzed. Animals were anesthetized with pentobarbital, and two microelectrodes separated by a few hundred microns were driven through the inferior colliculus. After collecting a sufficiently large sample of cells, sodium salicylate (450 mg/kg) was injected i.p. and recordings again made 2 h after the injection. Comparison of spontaneous activity recorded before and after salicylate administration revealed highly statistically significant differences (p less than 0.001). After salicylate, the mean rate of the cell population increased from 29 to 83 Hz and the median from 26 to 74 Hz. Control experiments in which sodium salicylate was replaced by saline injection revealed no statistically significant differences in cell discharges. Recordings made during the same experiments from lobulus V of the cerebellar vermis revealed no changes in response to salicylate. The observed changes in single-unit activity due to salicylate administration may represent the first systematic evidence of a tinnituslike phenomenon in animals.
D000161:Acoustic Stimulation; D000818:Animals; D002531:Cerebellum / Q000187:drug effects; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007245:Inferior Colliculi / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D012980:Sodium Salicylate / Q000494:pharmacology*; D014012:Tinnitus / Q000139:chemically induced*
D012980:Sodium Salicylate