Effects of glypressin on human nasal mucosa.
The effect of intravenous and topical glypressin, a triglycyl hormonogen of vasopressin, on the nasal mucosa was evaluated in healthy subjects. A dose-dependent reduction of nasal blood flow resulted from both intravenous and topical glypressin. The effect of the latter in gel form lasted 2 hours. Glypressin was also found to decongest the nasal mucosa. Topical application of glypressin gel might be an alternative to conventional treatment with intranasal packing in nose-bleed.
D000281:Administration, Intranasal; D000328:Adult; D003864:Depression, Chemical; D006801:Humans; D007275:Injections, Intravenous; D008236:Lypressin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009297:Nasal Mucosa / Q000098:blood supply / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D000077585:Terlipressin
D008236:Lypressin; D000077585:Terlipressin