Haematological changes induced in the mouse by the isomers of dimethylmyleran and myleran.
Both meso and racemic forms of dimethylmyleran are more powerful inhibitors of haematopoiesis than myleran. All produced a characteristic pattern of haematological response in which neutropenia predominated. Myleran exerted its severest depression of neutrophils immediately, whereas the isomers produced maximal damage a week later. Neutropenia induced by the +/- isomer was persistent for 3 weeks.
D000818:Animals; D002066:Busulfan / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D007536:Isomerism; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D051379:Mice; D009503:Neutropenia / Q000139:chemically induced
C002037:dimethylmyleran; D002066:Busulfan