title: [Pharmacodynamic and pharmacokinetic approaches to optimization of the use of digoxin in the subacute period of myocardial infarction in late middle-age and elderly patients].
abstract: The efficiency of digoxin in elderly and old patients with subacute myocardial infarction is dependent on the original disorders of left-ventricular systolic phase structure. Changes in systolic phase structural parameters in the presence of supporting digoxin therapy show correspondence to changes of these parameters in response to a single digoxin dose. Digoxin's positive inotropic effect was similar in patients with the sinus rhythm and those with atrial fibrillation. The positive inotropic action of digoxin is not associated with a negative chronotropic effect in patients with sinus rhythm and normal heart rate.
mesh_terms: D000368:Aged; D002302:Cardiac Output; D002303:Cardiac Output, Low / Q000188:drug therapy; D004077:Digoxin / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006352:Heart Ventricles; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D013599:Systole / Q000187:drug effects
chemical_list: D004077:Digoxin
vernacular_title: Farmakodinamicheskie i farmakokineticheskie podkhody k optimizatsii primeneniia digoksina v podostrom periode infarkta miokarda u bol'nykh pozhilogo i starcheskogo vozrasta.