title: Complex chromosomal rearrangement and multiple spontaneous abortions.
abstract: We report on a woman with a balanced complex chromosomal rearrangement (CCR) involving chromosomes 7, 10, and 21. She is the third individual with an apparently de novo CCR to be ascertained by repeated fetal wastage. Both familial and de novo CCRs are associated with recurrent spontaneous abortions.
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations / Q000150:complications / Q000235:genetics*; D025063:Chromosome Disorders; D002879:Chromosomes, Human, Pair 10 / Q000648:ultrastructure*; D002891:Chromosomes, Human, Pair 21 / Q000648:ultrastructure*; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D011247:Pregnancy; D014178:Translocation, Genetic