[Influence of the anti-inflammatory agent tenoxicam on gastric potential difference].
Tenoxicam (Ro 12-0068), a thienothiacine derivate which belongs to the oxicam class, has been developed for the treatment of rheumatic diseases. Standard antiinflammatory compounds are known for their irritative potency on the gastric mucosa. For this purpose a study was carried out with 15 volunteers after receipt of their informed consent, using the gastric potential difference model. The results of the study showed that tenoxicam is a compound with a low irritative potency on the gastric mucosa and that it is slightly superior to standard therapeutics.
D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology
D010894:Piroxicam; C032801:tenoxicam
Einfluss der antiinflammatorisch wirkenden Substanz Tenoxicam auf die gastrische Potentialdifferenz.