title: [Etimizol absorption from the small intestine in dogs: the dependence on dosage].
abstract: As etimizol has been previously reported to be of low bioavailability, the kinetics of its absorption from the dog intestinal loop was investigated in chronic experiments. After administration of etimizol at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively. It was concluded that overall etimizol absorption from small intestine was high and its low bioavailability resulted from presystemic drug metabolism, as well as that the absorption kinetics was dose-dependent, with saturation reached at higher drug doses.
mesh_terms: D000818:Animals; D001682:Biological Availability; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005042:Etimizol / Q000008:administration & dosage / Q000378:metabolism*; D007093:Imidazoles / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007420:Intestine, Large / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013997:Time Factors
chemical_list: D007093:Imidazoles; D005042:Etimizol
vernacular_title: Absorbtsiia étimizola iz tonkoĭ kishki sobak: zavisimost' ot dozy.