title: Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp.
abstract: Triacsins A and B, new inhibitors of acyl-CoA synthetase, were isolated from the cultured broth of Streptomyces sp. strain SK-1894. The structurally related compounds WS-1228 A and B, known as hypotensive vasodilators, were also found to inhibit acyl-CoA synthetase. The four compounds have in common a N-hydroxytriazene moiety in their structures. The IC50 values for triacsin A and WS-1228 A were 5.5 and 3.6 micrograms/ml, respectively.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D003066:Coenzyme A Ligases / Q000037:antagonists & inhibitors*; D005285:Fermentation; D013057:Spectrum Analysis; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D014226:Triazenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014226:Triazenes; C050241:triacsin A; C050242:triacsin B; C034613:triacsin C; C034614:triacsin D; D003066:Coenzyme A Ligases