Biosynthesis of lasalocid A. Biochemical alteration of polyether antibiotic production.
The effect of known precursors, their fluorinated analogs, and biochemical inhibitors on the production of the polyether antibiotic, lasalocid A (1), by resting cells of Streptomyces lasaliensis was determined to study the biochemistry and regulation of antibiotic biosynthesis in vivo.
D002569:Cerulenin / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D007832:Lasalocid / Q000096:biosynthesis*; D011422:Propionates / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism; D013386:Succinates / Q000494:pharmacology; D019802:Succinic Acid; D010135:p-Fluorophenylalanine / Q000494:pharmacology
D011422:Propionates; D013386:Succinates; D002569:Cerulenin; D010135:p-Fluorophenylalanine; D003513:Cycloheximide; D019802:Succinic Acid; D007832:Lasalocid