Failure of urinary MHPG levels to predict treatment response in patients with unipolar depression.
The authors studied 64 depressed patients who were receiving a vanillylmandelic acid (VMA)-free diet and underwent a washout period (mean, 24 days) before treatment. During the washout period, a mean of 2.5 multiple 24-hour urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) samples per patient were collected. Thirty-four patients were then treated with a "noradrenergic" antidepressant only (e.g., imipramine), and seven were treated with a "serotonergic" antidepressant only (e.g., amitriptyline). Twelve patients received combined drug treatment and 11 others spontaneously remitted. Response to treatment was rated on a clinical global evaluation scale from 1 (little or no response) to 7 (maximum response). No relationship was found between response to treatment, type of treatment, and the average pretreatment 24-hour urinary MHPG level. The authors thus failed to confirm the hypothesis that a low MHPG level predicts response to antidepressant treatment.
D000328:Adult; D000367:Age Factors; D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D011336:Probability; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors
D000928:Antidepressive Agents; D006018:Glycols; D000639:Amitriptyline; D008734:Methoxyhydroxyphenylglycol; D007099:Imipramine