title: Opioid-independent hyperalgesia induced in mice by pentobarbitone at low dosage.
abstract: The abdominal constriction (writhing) test was used to investigate the effect of pentobarbitone on nociception in mice. At dosages of 10, 20 and 30 mg/kg, pentobarbitone produced marked increases in nociceptive scores. The extent of the enhancement of nociception was uninfluenced by naloxone or swim-stress. The swim-stress induced analgesia but, in contrast to previous results using other tests for nociception, the analgesia was wholly non-opioid with the abdominal constriction test.
mesh_terms: D000818:Animals; D006930:Hyperalgesia / Q000139:chemically induced*; D006941:Hyperesthesia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010147:Pain Measurement; D010424:Pentobarbital / Q000494:pharmacology*; D013312:Stress, Physiological; D013550:Swimming
chemical_list: D010424:Pentobarbital