[Effect of the general anesthetic ketamine on the potassium permeability of plasma membranes of brain synaptosomes].
General anesthetic ketamine (1 mM) decreases relative sodium permeability (PNa+/PK+) of synaptosomes measured by transmembrane potential--external potassium concentration curves. Since tetrodotoxin (10(-7) M) does not affect the value PNa+/PK+ it is concluded that potassium permeability of the membrane increases in the presence of ketamine.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism*
D007649:Ketamine; D011188:Potassium
Vliianie obshchego anestetika ketamina na kalievuiu pronitsaemost' plazmaticheskikh membran sinaptosom mozga.