Mechanisms contributing to the anemia associated with a localized solid tumor.
The anemia associated with a localized solid tumor is a chronic hypoproliferative process referred to as the anemia of chronic disease. Several mechanisms responsible for this anemia have been proposed. A defect in iron reutilization was well accepted until challenged by a report in 1977. Evidence also exists to support bone marrow failure as a contributing factor. Using Wistar rats made anemic by implantation of Walker-256 carcinosarcoma cells, both possibilities were investigated. By injecting heat-damaged and nonviable 59Fe-labeled red cells, a mild but definite defect in the reutilization of iron was established. Bone marrow function was studied in a separate group of tumor-bearing rats by measuring erythron iron turnover. No difference was found between normal and tumor-bearing rats, suggesting relative bone marrow failure in the latter group.
D000740:Anemia / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D002279:Carcinoma 256, Walker / Q000097:blood / Q000150:complications* / Q000378:metabolism; D002908:Chronic Disease; D004912:Erythrocytes / Q000378:metabolism; D006400:Hematocrit; D007501:Iron / Q000097:blood / Q000378:metabolism; D007504:Iron Radioisotopes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007504:Iron Radioisotopes; D007501:Iron