title: [Nature of the organic lesions in uremic poisoning].
abstract: It was shown that a set of substances with median and low molecular weight obtained in sick children with chronic renal insufficiency by the method of ultrafiltration possessed pronounced biological activity. When injected to experimental animals they decreased the renal and hepatic arterial blood flow, caused microcirculatory alterations in vitally important organs, increased vascular permeability and activity of lysosomal enzymes.
mesh_terms: D000818:Animals; D002648:Child; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology; D051379:Mice; D008970:Molecular Weight; D014118:Toxins, Biological / Q000302:isolation & purification / Q000633:toxicity; D014462:Ultrafiltration; D014511:Uremia / Q000097:blood* / Q000503:physiopathology
chemical_list: D014118:Toxins, Biological; C026865:uremia middle molecule toxins
vernacular_title: Priroda organnykh porazheniĭ pri uremicheskoĭ intoksikatsii.