Aromatization of norethindrone to ethynylestradiol in human adult liver.
Homogenates of human adult liver are capable of aromatizing norethindrone (17 alpha-ethynyl-19-nortestosterone) to ethynylestradiol (17 alpha-ethynylestradiol). The evidence of ethynylestradiol formation was obtained using a Bio-Rad AG1-X2 column, thin layer chromatographies and co-crystallization. Neither acid nor base was used in any step in product identification.
D000328:Adult; D000368:Aged; D001141:Aromatase / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009640:Norethindrone / Q000378:metabolism*
D004997:Ethinyl Estradiol; D001141:Aromatase; D009640:Norethindrone