Aztreonam concentrations in human tissues obtained during thoracic and gynecologic surgery.
The concentrations of aztreonam in human tissues obtained during surgery were measured after a single 2-g intravenous dose. The average concentration in the skeletal muscle, atrial appendage, lung, sternum, pericardial fluid, endometrium, myometrium, fallopian tube, and ovary varied from 3 to 33 micrograms/g (or microgram/ml). These concentrations significantly exceed the MIC for 90% of strains for most members of the family Enterobacteriaceae.
D000368:Aged; D001398:Aztreonam / Q000378:metabolism* / Q000627:therapeutic use; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D011292:Premedication; D013903:Thoracic Surgery
D001398:Aztreonam