Formation of formaldehyde from S-adenosyl-L-[methyl-3H]methionine during enzymic transmethylation of histamine.
The experiments described here show that radiolabelled formaldemethone is formed from the radiolabelled methyl group of S-adenosyl-L-methionine in the course of the enzymic conversion of histamine to N tau-methylhistamine in the presence of dimedone suggesting that the formation of HCHO is probably linked to the enzymic transmethylation of histamine.
D000818:Animals; D005557:Formaldehyde / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism*; D006637:Histamine N-Methyltransferase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism*
D005557:Formaldehyde; D012436:S-Adenosylmethionine; D006632:Histamine; D008780:Methyltransferases; D006637:Histamine N-Methyltransferase