[Responses of neurons of intramural ganglia of the guinea pig pancreas to disruption of their connections with the CNS].
Morphologic and morphometric investigation of the intramural nervous apparatus of the pancreas has been performed on guinea pigs, normal and after subdiaphragmal vagotomy in 7, 14 and 60 days. According to the morphologic state, the neurons are divided into 8 groups. Morphometry of the perikaryon and nuclei is carried out after Stefanov method. The confidence interval is estimated according to Strelkov tables. In the experimental animals, during the time of the investigation certain quantitative redistributions of the neurons according to their groups are revealed. On the 7th day amount of neurons with phenomena of swelling and chromatolysis, and in two weeks amount of atrophied cells increase. The size of the neurons, after their increase on the 7th day of the experiment, decreases on the 14th day. By this time size of the nuclei decreases, too. On the 60th day after vagotomy morphometric parameters approach those of the control animals. The data of the investigation make it possible to distinguish 3 phases in development of the morphofunctional changes in the neurons: changes connected with functional strain of cells (in 7 days), destructive changes (in 14 days), compensatory-restorative rearrangements (in 60 days). It is possible to conclude that dynamics of morphofunctional rearrangements of neurons under the conditions, when connection with the CNS is disturbed, obey general regularities of the neurodistrophic process in the organs at their disturbed innervation.
D000818:Animals; D001284:Atrophy; D002467:Cell Nucleus / Q000473:pathology; D003714:Denervation; D005726:Ganglia, Parasympathetic / Q000473:pathology*; D006168:Guinea Pigs; D009410:Nerve Degeneration; D010179:Pancreas / Q000294:innervation*; D014628:Vagotomy
Reaktsiia neĭronov intramural'nykh gangliev podzheludochnoĭ zhelezy morskoĭ svinki na narushenie ikh sviazeĭ s TsNS.