Action of calcium channel inhibitors on acid gastric secretion in ulcer patients.
The action of an inhibitor of the calcium channels (Verapamil) on stimulated gastric acid secretion was studied in 14 patients with duodenal ulcer. Two histamine stimulations (0.5 mg) of acid gastric secretion were performed at an interval of 48 hrs, the second being preceded by Verapamil administration in doses of 80 or 120 mg. The results obtained, showed a varied response to the drug: decrease of acid secretion by 40% in half of the cases no influence or even increase of acid secretion in the rest of the cases. Correlation with the prevalent secretory type showed the inhibitory action of Verapamil in the beta-adrenergic-gastrin type thus pleading for an extracellular, probably membranous action of the drug.
D000863:Antacids; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D014700:Verapamil / Q000627:therapeutic use*
D000863:Antacids; D014700:Verapamil