title: Methotrexate in infusion solutions--a stability test for the hospital pharmacy.
abstract: The stability of methotrexate solutions, subject to a freeze-thaw procedure, has been investigated. According to our results these solutions can be produced in batches in the hospital pharmacy and thawed to room temperature immediately before use without any degradation of methotrexate within the time limits given.
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D005615:Freezing; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008727:Methotrexate / Q000008:administration & dosage*; D010607:Pharmacy Service, Hospital; D012996:Solutions
chemical_list: D012996:Solutions; D008727:Methotrexate