[Prevention of stress ulcers with cimetidine and ranitidine. Comparative studies within the scope of cardiosurgical interventions].
2 H2-receptor antagonists--Cimetidine and Ranitidine--were applied in our prospective randomized study in 100 cardio-surgical cases in order to test their therapeutical efficiency for the prophylaxis of bleedings of gastroduodenal stress-ulcers. During the phase of the intensive therapy of 2 days the patients of group A received t.i.d. 400 mg of Cimetidine i.v. and those of group B twice a day 150 mg of Ranitidine i.v. The following tests were realized: gastric acidity, plasma level, side-effects, hemorrhages and ulcers. The gastric 8 o'clock pH-level of group A (Cimetidine) during this intensive therapy was significantly (p = 0.0001) higher than the respective level of group B (Ranitidine). Other parameters were not showing any statistical differences between both groups. Acute gastro-intestinal hemorrhages because of stress-ulcers were not noticed during the test.
D002927:Cimetidine / Q000097:blood / Q000627:therapeutic use*; D003422:Critical Care; D004381:Duodenal Ulcer / Q000517:prevention & control*; D005260:Female; D005745:Gastric Acidity Determination; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control; D011183:Postoperative Complications / Q000517:prevention & control*; D011899:Ranitidine / Q000097:blood / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D002927:Cimetidine; D011899:Ranitidine
Prophylaxe von Stressulzera mit Cimetidin und Ranitidin. Vergleichende Untersuchungen im Rahmen von kardiochirurgischen Eingriffen.