Erythrocyte insulin receptors following myocardial infarction in non-diabetic subjects.
To determine whether changes in insulin receptors follow acute myocardial infarction, 10 non-diabetic patients were studied on admission to a coronary care unit and 24 h later. Erythrocyte insulin receptors were 86 (50-406) per cell [median (range)] initially and increased significantly to 203 (73-714). Maximum percent specific binding and 50% inhibition of tracer binding did not change significantly. Decreased receptor number after myocardial infarction may contribute to insulin resistance in the acute phase.
D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin