Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1.
Immunization of monkeys with yellow fever virus-specified nonstructural protein NS1 resulted in protection against fatal hepatitis as well as marked reduction in the magnitude of viremia after subcutaneous challenge with yellow fever virus. The results may be relevant to the design of possible subunit or recombinant flavivirus vaccines.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D003167:Complement Activation; D006023:Glycoproteins / Q000276:immunology; D007114:Immunization; D008253:Macaca mulatta; D009500:Neutralization Tests; D014764:Viral Proteins / Q000276:immunology*; D015004:Yellow Fever / Q000517:prevention & control*; D015005:Yellow fever virus / Q000276:immunology*
D000956:Antigens, Viral; D006023:Glycoproteins; D014764:Viral Proteins