Methylglyoxal-induced mutation to 6-thioguanine resistance in V79 cells.
Methylglyoxal, at concentrations ranging from 0.16 to 1.5 mM, caused a dose-dependent increase in the frequency of HGPRT-deficient mutants in V79 cells. Its mutagenic activity was reduced when V79 cells were co-cultured with freshly isolated rat hepatocytes.
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008099:Liver / Q000166:cytology; D009154:Mutation; D011765:Pyruvaldehyde / Q000633:toxicity*; D051381:Rats; D013866:Thioguanine / Q000494:pharmacology*
D000447:Aldehydes; D011765:Pyruvaldehyde; D007041:Hypoxanthine Phosphoribosyltransferase; D013866:Thioguanine