Inhibition of interferon-alpha/beta induction by crystalline cadmium sulfide.
The induction of interferon-alpha/beta by Newcastle disease virus in L-929 cells was inhibited by pretreatment of the cell cultures with the crystalline form of cadmium sulfide. As little as 10 micrograms/ml of crystalline cadmium sulfide was sufficient to inhibit the induction of interferon. Cell viability was not affected by this treatment as measured by trypan blue dye-exclusion viability staining. Between 6 and 24 hr of preincubation with crystalline cadmium sulfide was required for significant inhibition of interferon induction.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D019187:Cadmium Compounds; D002460:Cell Line; D003460:Crystallization; D004305:Dose-Response Relationship, Drug; D007369:Interferon Inducers / Q000037:antagonists & inhibitors*; D007370:Interferon Type I / Q000037:antagonists & inhibitors; D051379:Mice; D013440:Sulfides; D013997:Time Factors
D019187:Cadmium Compounds; D007369:Interferon Inducers; D007370:Interferon Type I; D013440:Sulfides; D002104:Cadmium; C034939:cadmium sulfide