Kibdelins, novel glycopeptide antibiotics. I. Discovery, production, and biological evaluation.
A new subspecies of Kibdelosporangium aridum subsp. largum (SK&F AAD-609), was isolated and shown to produce novel glycopeptides related to aridicins, but containing a homologous series of glycolipids based on N-acylglucosamine. These compounds showed improvements over the aridicins in in vitro activity and were effective in mouse protection studies against a range of Gram-positive bacteria, including methicillin resistant staphylococci. Pharmacokinetic studies indicated that they have high serum concentrations and long-acting potential. The kibdelin complex modified rumen metabolism in a manner favorable for growth promotion.
D000192:Actinomycetales / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D003470:Culture Media; D006020:Glycopeptides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D007422:Intestines / Q000382:microbiology; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D012417:Rumen / Q000382:microbiology; D013552:Swine
D000900:Anti-Bacterial Agents; D003470:Culture Media; D006020:Glycopeptides; C050686:kibdelin B; C050685:kibdelin A; C050687:kibdelin C1; C050688:kibdelin C2; C050689:kibdelin D