VIP and prolactin release in response to meals.
To determine the role of vasoactive intestinal polypeptide (VIP) and prolactin (PRL) in digestion, plasma VIP and PRL levels were measured in healthy, non-obese and obese premenopausal women fed isocaloric breakfasts containing a high carbohydrate or a high fat-protein content. A significant increase in plasma VIP concentration occurred after a high fat-protein breakfast, the increase being independent of body mass index. Plasma PRL level was unaltered by breakfast. Results suggest that the release of VIP after a meal depends on a high fat concentration in the duodenum, which may then stimulate bicarbonate release and fat-stimulated release of cholecystokinin.
D000328:Adult; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005260:Female; D005502:Food; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D011388:Prolactin / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D014660:Vasoactive Intestinal Peptide; D011388:Prolactin