title: Wen-jing-tang, a traditional Chinese herbal medicine increases luteinizing hormone release in vitro.
abstract: For examination of the effect on luteinizing hormone (LH) release of Wen-Jing-Tang, a traditional Chinese herbal medicine, the pituitary from normal female rats in diestrus was perifused alone or in sequence with the mediobasal hypothalamus (MBH) in a sequential double-chamber perifusion system. Wen-Jing-Tang at 5 or 500 micrograms/ml induced significant LH release (60-95% increase) from the pituitary in series with the MBH, but had no effect on LH release from the pituitary perifused alone. These data suggest that Wen-Jing-Tang induces LH release from the pituitary through hypothalamic LH-RH.
mesh_terms: D000818:Animals; D004031:Diestrus / Q000187:drug effects; D005260:Female; D007033:Hypothalamus, Middle / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D010902:Pituitary Gland / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007986:Luteinizing Hormone