title: Prostaglandin F2 alpha treatment of canine pyometra.
abstract: Immediate and long-term outcomes of prostaglandin F2 alpha treatment for canine pyometra were studied in 10 bitches. Examination of pretreatment uterine biopsy specimens, taken for histopathologic diagnosis and classification of disease severity, revealed either type III or IV pyometra. Dinoprost tromethamine (0.25 or 0.5 mg/kg of body weight, SC) was given once daily for 3 days. Bitches were bred at the first posttreatment estrus and monitored for a minimum of one year. When pure cultures of Escherichia coli (n = 3) or Staphylococcus aureus (n = 1) were obtained from the vagina, these bacteria also were found in the uterus. Pretreatment WBC counts often did not reflect the severity of histopathologic findings in the uterus, but posttreatment WBC counts were useful in monitoring response to treatment. Four bitches produced a litter within one year of treatment. Four bitches (40%) had recurrence of pyometra within one year of treatment, and these same bitches had another recurrence after an additional prostaglandin treatment. Three additional bitches had a recurrence by 27 months after therapy, establishing a total recurrence rate of 77% (7/9). Results suggested that subclinical disease may persist after treatment, with clinical recurrence during diestrus. Despite the high recurrence rate, it was concluded that this treatment is a practical treatment for canine pyometra when reproduction is desired.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D001706:Biopsy; D015237:Dinoprost / Q000031:analogs & derivatives*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005298:Fertility; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D012008:Recurrence; D014591:Uterine Diseases / Q000188:drug therapy / Q000662:veterinary*; D014599:Uterus / Q000473:pathology
chemical_list: D011461:Prostaglandins F, Synthetic; D015237:Dinoprost; C010714:dinoprost tromethamine