Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum.
Two cytotoxic sapogenols, the new hippocaesculin (1) and the known barringtogenol-C 21-angelate (2), were isolated from the acid hydrolysis product of a crude saponin fraction that was obtained from the fruits of Aesculus hippocastanum. The structures of 1 and 2 were determined from their chemical transformations and spectral data. Compound 1 is either 21-O-angeloyl, 22-O-tigloyl R1-barrigenol, or 21-O-tigloyl, 22-O-angeloyl R1-barrigenol.
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D006868:Hydrolysis; D007624:KB Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000032:analysis*; D012503:Saponins / Q000032:analysis / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins