Pharmacokinetic approach to equilibrium between ketanserin and ketanserin-ol.
The metabolic reduction-oxidation equilibrium between ketanserin and ketanserin-ol was studied after oral dosing of both substances to two healthy volunteers. Comparison of plasma Cmax and AUCs indicated that the equilibrium was shifted towards ketanserin-ol. There is evidence that ketanserin-ol elimination is the slowest step dictating the terminal half-life of ketanserin.
D000284:Administration, Oral; D000328:Adult; D006207:Half-Life; D006801:Humans; D007650:Ketanserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010084:Oxidation-Reduction
C039722:ketanserinol; D007650:Ketanserin