title: 2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria.
abstract: A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the metabolite could be a potential hazard in oxidation of fatty acids.
mesh_terms: D000603:Amino Acids, Sulfur / Q000378:metabolism*; D002849:Chromatography, Gas; D003555:Cystinuria / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D013058:Mass Spectrometry; D013438:Sulfhydryl Compounds / Q000652:urine*; D008625:Tiopronin / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000603:Amino Acids, Sulfur; D013438:Sulfhydryl Compounds; D008625:Tiopronin; C023884:thiolactic acid