The effect of chronic ethanol consumption on the tumorigenicity of N-nitrosopyrrolidine in male Syrian golden hamsters.
The effect of oral administration of ethanol on the tumorigenicity of N-nitrosopyrrolidine (NPYR) in chow-fed male Syrian golden hamsters has been investigated. Groups of hamsters were given tap water, 7.4% ethanol or 18.5% ethanol-water mixtures 4 weeks prior to and throughout the carcinogen administration period. A total dose of 1 mmol NPYR was administered by intraperitoneal injection to both tap water and ethanol-consuming animals over a 25-week period. Twenty-four hours after the last injection, ethanol-consuming animals were returned to tap water. In control animals treated with NPYR we observed 3/26 animals with tracheal papillomas, and 6/26 animals with hepatic neoplastic nodules. In animals receiving 7.4% ethanol-water mixtures, we observed 6/26 tracheal papillomas, and 17/26 hepatic neoplastic nodules. Similar results were observed in animals receiving 18.5% ethanol. These data indicate that chronic administration of ethanol to chow-fed hamsters increases the incidence of hepatic neoplastic nodules although no differences in the two levels of ethanol were observed.
D000437:Alcoholism / Q000150:complications*; D000818:Animals; D006224:Cricetinae; D004032:Diet; D002149:Energy Intake; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009242:N-Nitrosopyrrolidine / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D014134:Tracheal Neoplasms / Q000139:chemically induced
D009602:Nitrosamines; D009242:N-Nitrosopyrrolidine