Bactericidal activities of ten different fluoroquinolones against selected Enterobacteriaceae.
Ten fluoroquinolone compounds and two other 4-quinolones were tested in a microdilution system. Minimal inhibitory concentrations and minimal bactericidal concentrations were determined with 1 X 10(7) and 5 X 10(5) colony forming units per milliliter. All 12 compounds were bactericidal. Continued inhibition by drug carried over in the subcultured samples was documented and that represents a potential source of technical error that needs to be controlled when determining minimal bactericidal concentrations for these extremely potent drugs.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D006845:Hydrocarbons, Fluorinated; D011804:Quinolines