Effects of total and selective portasystemic shunting on hepatic haemodynamics and some aspects of liver function in the cirrhotic rat.
The effects of total and selective portasystemic shunting on hepatic haemodynamics and some aspects of liver function were studied in rats with dimethylnitrosamine-induced cirrhosis. Immediately following end-to-side portacaval shunting there were significant reductions in wedged hepatic venous pressure (WHVP) and liver blood flow. After side-to-side mesocaval shunting liver blood flow and wedged hepatic venous flow fell by approximately the same magnitude. Selective shunting (mesocaval 'H'-grafts and splenopancreaticocaval) preserved liver blood flow to a greater extent than total portasystemic shunting but had a less marked effect on WHVP. Furthermore, selective portasystemic shunting prevented liver atrophy and deterioration in liver function which was observed in rats following total portasystemic shunting. These results suggest that in the cirrhotic rat, selective portasystemic shunts which preserve functional liver blood flow and prevent liver atrophy and a deterioration in liver function do not produce such a marked decrease in WHVP as total shunts. Further studies in man are required to evaluate the relative advantages of total and selective portasystemic shunts.
D000818:Animals; D001201:Ascites / Q000628:therapy; D008099:Liver / Q000503:physiopathology; D008102:Liver Circulation; D008106:Liver Cirrhosis, Experimental / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008642:Mesenteric Veins; D011167:Portacaval Shunt, Surgical; D011170:Portasystemic Shunt, Surgical; D051381:Rats; D011919:Rats, Inbred Strains; D014682:Vena Cava, Inferior; D014690:Venous Pressure