[Thiol-disulfide metabolism as a mechanism in the formation of albumin minor fractions with pI 5.2-7.4 in various pathologic states].
The mechanism of formation of minor isoelectric fractions of albumin with pI 5.2-7.4 which arise in the blood channel with pathologies is studied. This phenomenon is nonspecific for any definite type of the disease and is possibly a result of the disease gravity. The mechanism of thiol-disulphide metabolism is shown to underlie the appearance of isoelectric fractions of albumin with pI 5.2-7.4. The fractions possess a lower ability to bind the bromo-phenol blue dye and a higher ability to bind penicillin.
D004220:Disulfides / Q000097:blood*; D006801:Humans; D007525:Isoelectric Focusing; D012709:Serum Albumin / Q000032:analysis*; D013438:Sulfhydryl Compounds / Q000097:blood*
D004220:Disulfides; D012709:Serum Albumin; D013438:Sulfhydryl Compounds
Tiol-disul'fidnyĭ obmen kak mekhanizm obrazovaniia minornykh fraktsiĭ al'bumina s pI 5,2-7,4 pri patologiiakh.