The effect of testosterone on the plasma disappearance rates of sulphadimidine and antipyrine in castrated dwarf goats.
Plasma disappearance of sulphadimidine and antipyrine was studied in adult castrated dwarf goats before and following pretreatment with testosterone. Comparison was made with entire males before and after castration. Testosterone pretreatment caused a significant increase in the apparent elimination half-life in castrates, whilst in entire males castration caused a significant decrease.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D006041:Goats / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D009919:Orchiectomy / Q000662:veterinary*; D013418:Sulfamethazine / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D013418:Sulfamethazine; D000983:Antipyrine