[Percutaneous resorption of testosterone, androstenedione and estradiol and their effect on serum steroid levels].
2.5 mg/m2 body surface of testosterone, 0.5 mg/m2 estradiol and 1.25 mg/m2 androstenedione were applied to the skin of healthy young men. The steroids were dissolved in a mixture of ethanol, water, and propylenglycol and applied to 10% of the body surface. Thus the amount given was equivalent to about one fifth of the amount in mg/m2. Serum levels of testosterone, androstenedione, and estradiol were measured by means of radioimmunology, both before the application as well as 2, 4, 8, and 24 h afterwards. Pregneolone and androstenedione did not alter the serum levels of the hormones determined. Testosterone and estradiol lead to a short peak of their serum concentration. Our results indicate that precursor steroids, pregnenolone and androstenedione, are rapidly metabolized to other compounds before they reach the blood in measurable amounts.
D000287:Administration, Topical; D000328:Adult; D000735:Androstenedione / Q000008:administration & dosage / Q000097:blood*; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D008297:Male; D012869:Skin Absorption; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood*
D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol
Die perkutane Resorption von Testosteron, Androstendion und Ostradiol und ihre Wirkung auf die Steroidserumpiegel.