title: Effect of tauroursodeoxycholate on the biliary transport maximum of sulfobromophthalein in the rat.
abstract: The effect of tauroursodeoxycholate (TU) infusion on the plasma level and biliary transport maximum (Tm) of sulfobromophthalein (BSP) was examined in male rats during a continuous intravenous infusion of BSP with different TU infusion rates. The infusion rate of 0.6 mumol/min/100 gm body weight of TU caused significantly higher bile flow and BSP Tm values compared with the respective control values in rats with only a BSP infusion. These values, however, were significantly lower than values obtained by an equimolar infusion of taurocholate (TC). The higher infusion rates of TU (1.2 and 1.8 mumol/min/100 gm) tended to cause higher bile flow rates, but the BSP Tm value did not increase beyond the value obtained at the lower infusion rate (0.6 mumol/min/100 gm). In the highest TU infusion rate study (1.8 mumol/min/100 gm), plasma BSP concentrations were significantly higher than corresponding control values or values at a lower TU or TC infusion rate. It was concluded that in rats TU can significantly increase the BSP Tm, but to a lesser extent than TC. Furthermore, it was suggested that TU infusion at a higher rate significantly interferes with the hepatic uptake (or storage) of BSP.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013448:Sulfobromophthalein / Q000378:metabolism*; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine