Reversible membranous glomerulonephritis associated with ketoprofen.
An 87-year-old woman presented with the nephrotic syndrome 12 months after administration of ketoprofen, 100 mg daily for osteoarthritis. Clinical course and laboratory data were consistent with drug-induced nephropathy. Kidney biopsy showed membranous glomerulonephritis. Evolution was favorable with resolution of proteinuria after drug withdrawal and steroid administration. A review of the literature on nephrotic syndrome associated with NSAID reveals membranous glomerulonephritis to be an unusual complication.
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D010003:Osteoarthritis / Q000188:drug therapy; D010666:Phenylpropionates / Q000009:adverse effects*
D010666:Phenylpropionates; D007660:Ketoprofen