The comparative effectiveness, under epidemic conditions, of the intradermal versus subcutaneous antityphoid vaccination estimated by epidemiological surveillance and laboratory tests.
The inhabitants of a territory in which a severe epidemic of typhoid fever appeared, were immunized intradermally or subcutaneously with heat-inactivated phenol preserved typhoid vaccine. The great majority of individuals received booster doses during the following three years. The specific immunization together with other epidemiologic and hygienic measures resulted in a quick extinction of the epidemic and the reduction in time of the number of typhoid carriers; no case of typhoid fever occurred in the following ten years among the vaccinated subjects. These satisfactory epidemiological results obtained by the two methods of vaccination were in accordance with serological laboratory tests performed in parallel on two supervised groups of the local population. The intradermal typhoid vaccination by the Dermojet presented a number of advantages (economic and rapid administration of the vaccine, mild postvaccinal reactions, etc.) and displayed at least an equal efficiency as compared with the administration of the vaccine by the subcutaneous route.
D000293:Adolescent; D000328:Adult; D000373:Agglutinins; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D002353:Carrier State / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D012485:Salmonella typhi / Q000276:immunology; D014435:Typhoid Fever / Q000453:epidemiology / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014611:Vaccination
D000373:Agglutinins; D000907:Antibodies, Bacterial; D014436:Typhoid-Paratyphoid Vaccines