Reye's syndrome. An epidemiologic analysis of mild disease.
Patients with Reye's syndrome (RS) whose degree of severity was classified as stage 0 (alert and awake) were compared with patients with a severity classification of stage 1 or greater. The Centers for Disease Control case definition and staging criteria were used. Two hundred twenty-seven patients with RS were investigated by the Ohio Department of Health from Dec 1, 1978, through March 31, 1980. There were 67 identified patients who never exceeded stage 0 and 160 patients classified as stage 1 or greater. Both groups of patients were compared according to demographic features, symptomatology, medication use during the antecedent illness, and laboratory findings during the RS illness. Stage 0 patients were similar to patients at stage 1 or greater in their demographic features, illnesses, medications preceding RS, and results of liver function tests; however, values of serum ammonia, creatine phosphokinase, prothrombin time, and bilirubin increased with RS severity.
D000082:Acetaminophen / Q000008:administration & dosage; D000641:Ammonia / Q000097:blood; D001241:Aspirin / Q000008:administration & dosage; D001663:Bilirubin / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D012202:Reye Syndrome / Q000097:blood / Q000145:classification* / Q000503:physiopathology
D000082:Acetaminophen; D000641:Ammonia; D001241:Aspirin; D001663:Bilirubin