[Synthesis of acyclic analogs of ribavirin].
A number of ribavirin analogues were prepared in which the ribose moiety was replaced with acyclic substituents imitating some fragments of the ribose ring: 2,3-dihydroxy-prop-1-yl, 3-hydroxymethyl-4-hydroxy-2-oxabut-1-yl, 4,5-dihydroxy-2-oxapent-1-yl and 1,5-dihydroxy-3-oxapent-2-yl. These analogues were synthesized by direct alkylation of ethyl 1,2,4-triazole-3-carboxylate with suitable agents followed by ammonolysis. New convenient methods for preparing the alkylating agents were developed.
D055598:Chemical Phenomena; D002621:Chemistry; D012254:Ribavirin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis*
D012263:Ribonucleosides; D012254:Ribavirin
Sintez atsiklicheskikh analogov ribavirina.