Pregnancy, delivery and lactation in hyperprolactinaemic women.
A report is given of 87 pregnancies in hyperprolactinaemic women treated with bromocriptine. The high prolactin level in 11 cases was caused by hypophyseal adenoma. If the plasma prolactin level exceeded 5000 mU/l during pregnancy, bromocriptine was administered until delivery. If the initial prolactin value was over 1000 mU/l, the prolactin level was measured during pregnancy, delivery and the lactational period. After weaning, the prolactin level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and congenital malformations, showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic patients need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The hyperprolactinaemic syndrome did not deteriorate during gestation and lactation, but its normalization can not be expected.
D001971:Bromocriptine / Q000627:therapeutic use; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000188:drug therapy; D007231:Infant, Newborn; D007774:Lactation; D007744:Obstetric Labor Complications / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D011388:Prolactin / Q000097:blood
D001971:Bromocriptine; D011388:Prolactin