Aspiration pneumonia caused by fibrous material in rats.
Aspiration pneumonia observed in eight of 60 Sprague-Dawley rats which were orally treated with 0.5% carboxymethyl cellulose solution was investigated. Grossly, the lung showed white nodular foci in the parenchyma. Histologically, changes were characterized by fibrous material accompanied by inflammatory cells in the alveoli and bronchioles and formation of granulomas. It appeared that the inhaled fibrous material had originated from the carboxymethyl cellulose solution.
D000280:Administration, Inhalation; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000009:adverse effects; D011015:Pneumonia, Aspiration / Q000139:chemically induced* / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions
D012996:Solutions; D002266:Carboxymethylcellulose Sodium