D-glucose anomers in the nucleus of the tractus solitarius can reduce gastric acid secretion of rats.
The infusion of alpha-, beta-, or equilibrated (alpha:36%, beta:64%) D-glucose solution in or in the vicinity of the nucleus of the tractus solitarius decreased gastric acid output caused by insulin in rats with bilateral adrenalectomy. This effect was not reproduced after vagotomy at the cervical level. Of the three forms of D-glucose solution, the effect of beta-D-glucose was greatest. The infusion of equitonic NaCl, however, produced no change in the acid output. These results suggest that blood beta-D-glucose may predominantly activate a brain mechanism which through the vagus nerve modulates gastric acid secretion at the medullary level.
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D005947:Glucose