[Pharmacologic activity of 1-lupinylquinoxalin-2(1H)-ones, 3,6-disubstituted].
Five 1-lupinyl-3R'-6R"-quinoxalin-2(1H)-ones were tested in mice for acute toxicity, explorative activity inhibition, analgesic activity and for antagonism against physostigmine, strychnine and pentylentetrazol (cardiazol). As reference compounds were used chloropromazine, morphine, atropine and diazepam respectively. All tested compounds inhibit the explorative activity and exhibit high analgesic activity. Compound (I) protects completely the animals from physostigmine toxicity, while compound (IV) antagonizes, although only slightly, all the toxicants tested.
D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010830:Physostigmine / Q000037:antagonists & inhibitors; D011810:Quinoxalines / Q000494:pharmacology* / Q000633:toxicity
D000470:Alkaloids; D000700:Analgesics; D000927:Anticonvulsants; D011810:Quinoxalines; D010830:Physostigmine
Attività farmacologica di 1-lupinilchinossalin-2(1H)-oni 3,6-disostituiti.