[Infectivity of influenza viruses for an organ culture of human embryonic trachea and the change in this trait in recombination].
The infecting and reproduction activity of epidemic and vaccine strains of influenza virus as well as their recombinants was studied in human embryo trachea culture. At a certain combination of genes the recombinants showed new qualities: increased tropism to cells of the human upper respiratory tract and intensified virus reproduction in these cells. Of special interest was a recombinant containing the inner proteins of A/Leningrad/9/46 (H0N1) virus and external proteins of A/Brazil/11/78 (H1N1) virus. A possible association of the genes of the internal proteins of influenza A/Leningrad/9/46 virus with the intensity of reproduction, and of the genes of surface glycoproteins with the species specificity of this recombinant is discussed.
D005814:Genes, Viral; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D009924:Organ Culture Techniques; D011995:Recombination, Genetic; D014132:Trachea / Q000382:microbiology*; D014764:Viral Proteins / Q000235:genetics; D014774:Virulence; D014776:Virus Cultivation; D014779:Virus Replication
D014764:Viral Proteins
Infektsionnost' virusov grippa dlia organnoĭ kul'tury trakhei émbriona cheloveka i izmenenie dannogo priznaka pri rekombinatsii.