[Immunologic and pharmacologic activity of atropine-protein conjugates].
The immunological (production of specific antibodies to hapten) and pharmacological activity of bovine serum albumin conjugates with different chemical modifications of atropine was investigated. Mice and rabbits treated with atropine-protein conjugates (1-10 mg/kg) have produced a considerable number of specific serum antibodies to hapten during primary and secondary immune response. Mice treated with atropine-protein conjugates (25 and 50 mg/kg) have produced undetectable amounts of specific serum antibodies. The study of pharmacological activity in mice has revealed peripheral activity of atropine-protein conjugates. There was a correlation between the pharmacological activity of atropine-protein conjugates (25-50 mg/kg) and the activity of atropine (5 mg/kg), however the pharmacological effect of atropine-protein conjugates was somewhat longer. The results suggest that atropine-protein conjugates are both immunologically and pharmacologically active compounds.
D000818:Animals; D000917:Antibody Formation; D001286:Atropine Derivatives / Q000276:immunology* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D051379:Mice; D010276:Parasympatholytics / Q000276:immunology / Q000494:pharmacology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000276:immunology* / Q000494:pharmacology
C051015:4-carboxyphenylazoatropine-bovine serum albumin conjugate; D001286:Atropine Derivatives; D010276:Parasympatholytics; C051016:atropine hemisuccinate-bovine serum albumin conjugate; D012710:Serum Albumin, Bovine
Immunologicheskaia i farmakologicheskaia aktivnost' belkovykh kon"iugatov atropina.