Comparative investigation of the microcirculation in patients with hypertension and healthy adults.
A total of 51 patients with arterial hypertension, 29 of which have renal dysfunction, were examined with regard to patient history, clinically, laboratory analysis and capillary microscopy. Compared to healthy adult patients with hypertension demonstrated a significant increase in the number of capillaries per millimeter of epidermis, while at the same time showing a significantly decreased erythrocyte column diameter. This observation was more pronounced the greater the degree of retinal vascular alteration (fundus hypertonicus). The duration of reactive hyperemia in response to three minutes of ischemia with a spygmonometer cuff was considerably shortened in patients with hypertension. Here as well, an increasing degree of retinal vascular alteration correlated with a decrease in reactive hyperemia to the point of no response at all. The blood fluidity of patients with arterial hypertension was significantly limited. The plasma viscosity as well as the erythrocyte aggregation were significantly elevated. Patients suffering from additional kidney dysfunction had even higher viscosities. There also appeared to be a correlation to the degree of fundus hypertonicus in which the plasma viscosity increased in relation to an increasing degree of retinal vascular alteration.
D000328:Adult; D001783:Blood Flow Velocity; D001809:Blood Viscosity; D002196:Capillaries / Q000503:physiopathology; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000503:physiopathology; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008833:Microcirculation / Q000503:physiopathology*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D012212:Rheology