title: The nicotinic-induced release of endogenous dopamine from rat striatal slices from animals chronically exposed to dimethylphenylpiperazinium (DMPP).
abstract: The effect of the nicotinic agonist, dimethylphenylpiperazinium (DMPP), to release endogenous dopamine (DA) from striatal slices obtained from animals chronically treated with the nicotinic agonist for 7 or 14 days was determined. Endogenous DA was measured by high pressure liquid chromatography coupled to electrochemical detection. There was no difference in the DMPP concentration-effect curve for DA release from slices obtained from untreated rats or rats treated with saline. Treatment with DMPP for 7 days did not change the DMPP concentration-effect curve when compared to saline treatment. In contrast, treatment of rats with DMPP for 14 days resulted in a significant attenuation of the DMPP-induced release of DA. These studies support the hypothesis that chronic treatment with nicotinic agonists results in a functional uncoupling of cholinergic nicotinic receptors facilitating DA release in the striatum.
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000187:drug effects*; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D010879:Piperazines; D011978:Receptors, Nicotinic; D004246:Dimethylphenylpiperazinium Iodide; D004298:Dopamine