Inhibition of the excitatory junction potential in the guinea-pig saphenous artery by ANAPP3.
Electrical stimulation of the perivascular nerves of the guinea-pig saphenous artery elicited excitatory junction potentials (e.j.ps) in the smooth muscle cells. These e.j.ps were inhibited by arylazido aminopropionyl adenosine triphosphate (ANAPP3), a specific antagonist for the P2-purinoceptor, suggesting that ATP may be the neurotransmitter.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000294:innervation; D001386:Azides / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects*
C012761:3'-O-(3-(N-(4-azido-2-nitrophenyl)amino)propionyl)adenosine-5'-triphosphate; D001386:Azides; D000255:Adenosine Triphosphate