title: The recurrence risks for isolated cases with incompletely penetrant X-linked conditions.
abstract: The recurrence risks for an X-linked disease with incomplete penetrance are evaluated for a sib given that an isolated proband (male or female) is affected. The derived formulae are applied to the X-linked form of Alport and fragile X syndromes.
mesh_terms: D004843:Epistasis, Genetic; D005260:Female; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011336:Probability; D012306:Risk; D014960:X Chromosome