5-HT2 antagonists reduce ON responses in the rabbit retina.
We have investigated the effects of serotonin (5-HT2) antagonists in the rabbit retina. These antagonists reduce the ON responses of ON-center cells as well as the surround (ON) responses of OFF-center cells, and enhance the center (OFF) responses of the latter cells. The result is consistent with the anatomy of the indoleamine-accumulating cells in the rabbit retina, which ramify in sublamina b (ON) of the inner plexiform layer and contact primarily bipolar cells that are depolarizing in the rabbit. This suggests that at least part of the surround (ON) responses to OFF-center cells is generated in the inner plexiform layer.
D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D007650:Ketanserin / Q000494:pharmacology; D010775:Photic Stimulation; D011817:Rabbits; D012160:Retina / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*
D002090:Butyrophenones; D004873:Ergolines; D012702:Serotonin Antagonists; C005569:pipamperone; D007650:Ketanserin; C032663:LY 53857