Carminic acid-promoted oxygen radical damage to lipid and carbohydrate.
The food colouring carminic acid redox cycles to produce free radicals. These radicals, in the presence of trace amounts of iron salts, readily damage membrane lipid and degrade the carbohydrate deoxyribose. Damage to membrane lipid appears to involve mainly organic oxygen radicals such as alkoxy and peroxy radicals, whereas that to deoxyribose implicates the hydroxyl radical formed in a Fenton-type reaction. Antioxidants and iron chelators prevent such damage.
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D001921:Brain; D002329:Carmine / Q000031:analogs & derivatives / Q000633:toxicity*; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003855:Deoxyribose; D005609:Free Radicals; D008081:Liposomes; D008563:Membrane Lipids; D010100:Oxygen
D000880:Anthraquinones; D005609:Free Radicals; D008081:Liposomes; D008563:Membrane Lipids; D003855:Deoxyribose; D002329:Carmine; D010100:Oxygen