Synthesis and antitumor activity of a platinum (II)-doxorubicin complex.
A mixed platinum (II) complex with tert-butylamine and doxorubicin (coordinated via the amino-group) has been synthesized and tested for antitumor activity. The results indicate that the complex was active against doxorubicin-resistant P388 and cisplatin-resistant L1210 leukemias, while maintaining antitumor activity against sensitive parent lines.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010984:Platinum / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010984:Platinum; D004317:Doxorubicin