[Pyridoxine can normalize oxaluria in idiopathic renal lithiasis].
Pyridoxine (vitamin B6), given to patients with primary hyperoxaluria of type I, generally leads to a decrease in urinary excretion of oxalate owing to stimulation of conversion of glyoxylate to glycine instead of oxalate. It is not known, however, whether pyridoxine would equally influence hyperoxalurias of other origins, e.g. idiopathic or enteric. Two groups of patients were therefore given pyridoxine orally for 2 months (300 mg/d). Group 1 consisted of 10 idiopathic stone formers with mild hyperoxaluria of unknown origin. Group 2 consisted of 4 patients with enteric hyperoxaluria after intestinal bypass surgery. As a mean, enteric hyperoxaluria was not influenced by vitamin B6, which suggests that this disorder is the consequence of intestinal hyperabsorption of oxalate rather than of glyoxylate. In contrast, idiopathic hyperoxaluria was influenced by vitamin B6: urinary excretion of oxalate decreased in 8 patients out of 10 and became normal in 7. However, two patients did not respond to pyridoxine; both had concomitant severe hyperuricosuria (greater than 1 g/24 h), an observation suggesting that in these cases hyperoxaluria was of dietary origin. Four of the patients whose urinary excretion of oxalate became normal while on pyridoxine were followed up for 8 to 36 months after treatment: in all of them oxaluria remained normal. One whose oxaluria had returned to the upper normal limit was retreated after 2 years and again displayed a fall in urinary oxalate. It is concluded that pyridoxine given to idiopathic hyperoxalurics may correct the disorder, as in primary hyperoxaluria of type I; this is not the case in enteric hyperoxaluria. The mechanisms governing this sensitivity to vitamin B6 remain to be clarified.
D000328:Adult; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000188:drug therapy*; D006960:Hyperoxaluria, Primary / Q000188:drug therapy* / Q000652:urine; D007581:Jejunoileal Bypass; D007669:Kidney Calculi / Q000150:complications / Q000188:drug therapy* / Q000652:urine; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000652:urine; D011183:Postoperative Complications / Q000188:drug therapy / Q000652:urine; D011736:Pyridoxine / Q000627:therapeutic use*; D013997:Time Factors
D010070:Oxalates; D011736:Pyridoxine
La pyridoxine peut normaliser l'oxalurie dans la lithiase rénale idiopathique.