Coronary dilator effect of MCI-176, a new calcium channel blocker, in dogs.
Effects of MCI-176, 2-(2,5-dimethoxyphenylmethyl)-3-(2-dimethylaminoethyl)-6-isopropox y-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison with those of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In producing these effect MCI-176 was slightly but significantly more potent than diltiazem. Heart rate tended to increase with MCI-176, whereas it tended to decrease with diltiazem.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004110:Diltiazem / Q000494:pharmacology; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D011799:Quinazolines / Q000494:pharmacology*; D052999:Quinazolinones
D011799:Quinazolines; D052999:Quinazolinones; C050606:MCI 176; D004110:Diltiazem