Inhibitory effect of female hormones on lipid peroxidation.
The female hormones estradiol, estrone, and estriol acted as antioxidants in the peroxidation of methyl linoleate by UV irradiation. All of them inhibited the peroxidation of microsomal lipids when they were added to the ADP-Fe3+ peroxidation system of rat liver microsomes. The efficiencies in the microsomal system were in the order of estradiol greater than estriol greater than estrone.
D000818:Animals; D013196:Dihydrotestosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism* / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D014466:Ultraviolet Rays
D004967:Estrogens; D008054:Lipid Peroxides; D013196:Dihydrotestosterone; D004970:Estrone; D004958:Estradiol; D004964:Estriol