title: Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.
abstract: Severe psoriasis is commonly associated with depression and may be its cause. The hazards of treating such patients with lithium are well known (Lazarus & Gilgor, 1979), but other drugs may also destabilize psoriasis. We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000139:chemically induced* / Q000523:psychology; D014196:Trazodone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D014196:Trazodone