[Disorders of immunologic homeostasis as affected by radioactive iodine preparations].
(CBA X C57B1/6)F1 mice were injected with 125I and 131I-sodium iodide at a dose of 5.74 X 10(4) Bq/g. For a long time after such treatment the animals manifested an increased level of spleen cells humoral immune response to a foreign antigen (sheep erythrocytes), the autoreactivity of spleen and lymph node lymphocytes to autologous erythrocytes was also elevated. At the same time the selective migration of 51Cr-labeled spleen lymphocytes to the peripheral lymphoid organs was suppressed. The use of a model system of adoptive cell transfer revealed an increase in the functional activity of cells suppressing a humoral response in mice treated with radiopharmaceuticals. The most pronounced disturbances of immunological reactivity in mice took place 6 mos. after the beginning of the experiment. The results obtained indicated that mechanisms of immune response regulation played a certain role in disturbances of immunological homeostasis induced by radioactive iodine agents.
D000818:Animals; D006706:Homeostasis / Q000528:radiation effects*; D007109:Immunity / Q000528:radiation effects*; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D051379:Mice
D007457:Iodine Radioisotopes
Narusheniia immunologicheskogo gomeostaza pod deĭstviem preparatov radioaktivnogo ĭoda.