[Slow elimination of a prazosin metabolite compared to prazosin kinetics after its intravenous administration to rabbits].
Serum concentration profiles of prazosin and its metabolite 2-(1-piperazinyl)-4-amine-6,7-dimethoxyquinazoline after intravenous bolus administration to rabbits (0.5 mg/kg) were shown to be biphasic. Rapid decline related to distribution was followed by a terminal slope lasting for up to 24 hours. Prazosin level in this phase decreased, its elimination half-life being about 9 hours, while the metabolite serum level was almost constant between 4 and 24 hours and averaged 0.9 mumol/l. This is in keeping with the earlier suggested extremely low elimination rate of this metabolite. Enterohepatic recirculation may account for this phenomenon, as well as a significant rise in the metabolite serum concentration I hour after the injection.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007700:Kinetics; D008657:Metabolic Clearance Rate; D011224:Prazosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood*; D011817:Rabbits; D013997:Time Factors
C050977:2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline; D011224:Prazosin
Zamedlennaia éliminatsiia metabolita prazozina v sravnenii s kinetikoĭ prazozina posle vnutrivennogo vvedeniia krolikam.