A nonlinear tissue-binding model for creatine: estimation of creatine turnover time and creatinine production rate.
Intravenous bolus injections of 14C-labeled creatine were made in rabbits. Plasma and urine concentrations were measured. Plasma specific activity and urinary cumulative radioactivity data were examined by several means including the use of NONLIN. Utilization of urine and blood data suggested that a nonlinear model was more appropriate. The selected model has two nonlinear binding parameters and an elimination rate constant. The creatine turnover time was calculated to be about 22 minutes. The model allows the predication of creatine production rate that is in general agreement with the literature values.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003401:Creatine / Q000378:metabolism*; D003404:Creatinine / Q000096:biosynthesis; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011817:Rabbits; D014018:Tissue Distribution
D003404:Creatinine; D003401:Creatine