[Glycolysis in the rat kidney shortly after ischemia and administration of calmodulin inhibitors, AMP and NAD].
It is shown in experiments on rats that the early postischemic period after 1- and 1.5-hour ischemia of kidneys is characterized by a decrease in the damage of the glycolytic system site which induces glucose-6-phosphate transformation into lactate and by an increase in the inhibition intensity of the initial hexokinase reaction of glycolysis. In the postischemic period after more prolonged (2-, 3-hour) ischemia the damage of the glycolytic system develops also at the site of glucose-6-phosphate transformation into lactate. Administration either of the nucleotide complex (NAD and AMP) or calmodulin inhibitors (aminazine and zinc sulphate) to rats prior to two-hour occlusion of kidneys vessels promotes a decrease in the inhibition of the glycolytic system activity in the postischemic period. At the same time the separate and combined application of zinc sulphate and triftazin (the most intensive calmodulin inhibitor) is not efficient. The positive effect of NAD, AMP and aminazine on the state of the glycolytic kidney system in the postischemic period correlates with the improvement of the blood microcirculation processes in them.
D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002746:Chlorpromazine / Q000494:pharmacology; D006019:Glycolysis; D007511:Ischemia / Q000201:enzymology / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D009243:NAD / Q000494:pharmacology*; D051381:Rats; D013431:Sulfates / Q000494:pharmacology; D013997:Time Factors; D014268:Trifluoperazine / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology; D019287:Zinc Sulfate
D002147:Calmodulin; D013431:Sulfates; D009243:NAD; D014268:Trifluoperazine; D000249:Adenosine Monophosphate; D019287:Zinc Sulfate; D015032:Zinc; D002746:Chlorpromazine
Glikoliz v pochkakh krys v ranniĭ period posle ishemii i pri vvedenii ingibitorov kal'modulina, AMP i NAD.