Occurrence of alkaline phosphatase-positive fibers in experimental muscle disorders.
The alkaline phosphatase (AP) reaction was carried out on muscle sections from a large series of rats under various experimental neuromuscular disorders. Only denervated and non-innervated muscle fibers stained positively with the AP reaction. In other conditions including degenerating, regenerating, tenotomized and immature muscles the AP reaction was negative. This suggests that the presence of AP-positive fibers in human neuromuscular disorders reflects a concomitant denervation process.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002045:Bupivacaine; D006651:Histocytochemistry; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D009468:Neuromuscular Diseases / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration
D000469:Alkaline Phosphatase; D002045:Bupivacaine