[Radiation sensitivity of aerated and hypoxic clonogenic cells of Ehrlich ascites carcinoma].
The authors presented comparative results on the survival of ascitic Ehrlich's carcinoma (AEC) clonogenic cells during exposure to 60Co gamma-beam radiation under the hypoxic and oxygenated conditions in vitro. A well-known method of hypoxia induction in dense cell suspensions by way of forced cell precipitation into a dense precipitate by a short-term suspension centrifugation was modified. Radiosensitivity of such hypoxic cells was characterized by a DO value of 6.59 +/- 0.29 Gy, and that of well oxygenated cells by 2.06 +/- 0.05 Gy. The oxygen enhancement ratio, determined as a ratio of DO values for hypoxic and oxygenated cells, was 3.2.
D000388:Air; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000532:radiotherapy*; D002999:Clone Cells / Q000528:radiation effects*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D051379:Mice; D010101:Oxygen Consumption; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage
D003037:Cobalt Radioisotopes
Radiochuvstvitel'nost' aérirovannykh i gipoksicheskikh klonogennykh kletok astsitnoĭ kartsinomy Erlikha.