Correlation between dosage and antipyretic effect of aspirin in children.
One hundred and forty-five children aged 3 months to 11.5 years, with rectal temperatures greater than 38.9 degrees C, were randomly treated with aspirin 5, 10 or 15 mg/kg p.o. Temperatures were recorded just before medication, every 30 min thereafter for 4 h and subsequently hourly up to 6 h. In all dosage regimens the average temperature was significantly reduced in the time interval 1-6 h after drug administration; the antipyretic effect, however, was significantly greater with the 10 and 15 mg/kg doses. Both had significantly better and comparable clinical efficacy, defined as reduction in fever below 38.9 degrees C. The duration of the clinical effect was not dose-related. A dose of 10 mg/kg appears rational for the treatment of children with fever.
D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011897:Random Allocation; D013997:Time Factors
D001241:Aspirin