The effects of Triton WR-1339, protamine sulfate and heparin on the plasma removal of emulsion models of chylomicrons and remnants in rats.
Protein-free lipid emulsions with compositions modelling chylomicrons (chylomicron-like emulsion) or chylomicron remnants (remnant-like emulsion) were injected intra-arterially into nonanesthetized rats. Compared with control untreated rats, treatment with Triton WR-1339, protamine sulfate or heparin strongly modified the plasma removal of triacylglycerols and cholesteryl ester moieties of chylomicron-like emulsions, but had little effect on removal rates of triacylglycerols or cholesteryl esters of remnant-like emulsions. The effects on chylomicron-like removal were similar to those on natural lymph chylomicrons. The relative lack of effects on remnant-like emulsion removal provides additional evidence that remnant-like emulsions are a metabolic model for natural chylomicron remnants.
D000818:Animals; D002788:Cholesterol Esters / Q000097:blood; D002914:Chylomicrons / Q000097:blood*; D004655:Emulsions; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011479:Protamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D002914:Chylomicrons; D004655:Emulsions; D011479:Protamines; D014280:Triglycerides; D011092:Polyethylene Glycols; D006493:Heparin; C016811:tyloxapol