[Comparative evaluation of the action of cis-dichlorodiammineplatinum and oxoplatinum on hemopoiesis un mice].
Myelosuppressive effects of cis-dichlorodiamminoplatinum (DDP) and oxoplatinum have been revealed. The administration of these drugs leads to early and deep depletion of CFU compartment. The most rapid rate of reduction was registered during 24-48 hours after DDP administration and within first three hours after oxoplatinum administration. Reduction of the total bone marrow cellularity caused mainly by a decrease of erythroid cells and, to a less extent, by a decrease of lymphoid and myeloid cells is observed. Leukopenia and anemia have developed during the treatment. Myelosuppressive effects are more pronounced with the oxoplatinum administration. A strict correlation is established between the haemopoietic tissues damage and the level of platinum content in the animal organism.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D003864:Depression, Chemical; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013997:Time Factors
D000970:Antineoplastic Agents; D002945:Cisplatin; C043804:diamminedichlorodihydroxyplatinum IV
Sravnitel'naia otsenka deĭstviia tsis-dikhlordiamminoplatiny i oksoplatina na gemopoéz u mysheĭ.