title: The effect of activated charcoal on mouse sleep times induced by intravenously administered hypnotics.
abstract: The effect of orally administered activated charcoal (AC) on the sleep times of mice following intravenous injection of various hypnotics was investigated. Preliminary studies with phenobarbital (Pb) showed that a linear relationship exists between the Pb-induced sleep time and the logarithm of the Pb dose in both control and AC treated mice. Half-lives of Pb in the two groups were estimated to be 8.1 and 0.9 h, respectively. A linear decline in Pb-induced sleep time with increasing dose of AC was observed up to a maximum effective dose of AC beyond which dose increments caused no further reduction in sleep time. A similar relationship was observed between sleep time and the concentration of sodium sulfate in which the AC was suspended. AC treatment resulted in an 82-88 per cent reduction in sleep time induced by administration of phenobarbital, methyprylon, glutethimide, ethchlorvynol, and methaqualone. AC had no significant effect on sleep time following amobarbital or pentobarbital administration.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002606:Charcoal / Q000008:administration & dosage*; D004347:Drug Interactions; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007275:Injections, Intravenous; D051379:Mice; D010634:Phenobarbital / Q000008:administration & dosage; D012890:Sleep / Q000187:drug effects*; D013431:Sulfates / Q000008:administration & dosage
chemical_list: D006993:Hypnotics and Sedatives; D013431:Sulfates; C012036:sodium sulfate; D002606:Charcoal; D010634:Phenobarbital