Cellular energy charge in the heart and liver of the rat. The effects of ethanol and acetaldehyde.
The effects of ethanol and acetaldehyde upon adenine nucleotide concentrations in rat heart and liver were determined. Ethanol administered either acutely (8 g kg 0.73) or chronically (20% solution in drinking water for 21 d) significantly decreased ATP concentrations, adenylate energy charge (EC) and adenylate kinase mass action ratio (gamma AK) in liver but affected gamma AK only in heart. Acetaldehyde treatment elicited similar effects but of lesser magnitude.
D000079:Acetaldehyde / Q000494:pharmacology*; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D000227:Adenine Nucleotides; D000431:Ethanol; D000079:Acetaldehyde