Female sex hormones suppress development of collagen-induced arthritis in mice.
We have previously reported that male DBA/1 mice are more susceptible to collagen-induced arthritis than are females. Here we report that oophorectomy makes female mice as susceptible to collagen arthritis as are normal males. Induction of collagen-induced arthritis in mice is a T cell-dependent process. The role of female sex hormones in modulating T cell-dependent autoimmune diseases is discussed.
D000818:Animals; D001168:Arthritis / Q000139:chemically induced*; D001323:Autoantibodies / Q000032:analysis; D002369:Castration; D003094:Collagen / Q000037:antagonists & inhibitors* / Q000145:classification / Q000276:immunology / Q000494:pharmacology; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012727:Sex Characteristics; D012730:Sex Chromosomes / Q000502:physiology; D014998:Y Chromosome / Q000502:physiology
D001323:Autoantibodies; D012739:Gonadal Steroid Hormones; D003094:Collagen