[Experimental animal studies of compensatory renal adaptation of residual nephrons in physical stress caused by daily swim training].
The influence of a regular physical training after unilateral nephrectomy carried out on the experimental animal rat on the function of the residual kidney was investigated. A significant decrease of the glomerular filtration rate by 22% and an increase of TmPAH by 36% in the loaded animals could be proved 12 weeks after unilateral nephrectomy and two-month load by swimming training. These findings allow the interpretation that physical conditioning for adapting nephrons may be regarded as progression as well as protection factor. Additional long-term investigations are necessary to clarify this problem and finally to prove present therapeutic recommendations for the physical conditioning with regard to prove protective reactions to the renal compensatory adaptation of the residual nephrons without any doubt.
D000222:Adaptation, Physiological; D000818:Animals; D005260:Female; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D007677:Kidney Function Tests; D009392:Nephrectomy; D009399:Nephrons / Q000503:physiopathology*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013550:Swimming
Tierexperimentelle Untersuchungen zur renalen kompensatorischen Adaptation residueller Nephrone bei physischer Belastung durch tägliches Schwimmtraining.