[Method of adjusting the netilmicin dosage in neonatal intensive care].
We tried to adapt the dose of netilmicin in an intensive care unit on 41 newborns, under 8 days of age. Individual pharmacokinetic parameters were calculated after the first intramuscular dose administration and the initial dose (3 mg/kg/twice a day) was modified in 17 cases. Methodologic problems but mainly great variations in physiology and pathology explain the difficulties in predicting the serum concentration (peak and valley) on the 7th day. A decrease in the daily dose for the preterm infant, compared to the one used in full-term infant, and a drug concentration monitoring are advised.
D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy*; D007233:Infant, Postmature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy; D007363:Intensive Care Units, Neonatal; D007700:Kinetics; D009428:Netilmicin / Q000008:administration & dosage* / Q000097:blood
D009428:Netilmicin
Méthode d'ajustement de la posologie de la netilmicine en réanimation néonatale.