title: The man-made mineral fiber European historical cohort study. Extension of the follow-up.
abstract: The study concentrated on 21,967 workers producing rock wool/slag wool, glass wool or continuous filament in 13 European factories. The expected deaths and incident cancer cases were derived from multiplying the accumulated person-years by national reference rates across sex, age, and calendar-year strata, correction factors for regional lung cancer mortality also being used. Exposure assessment was based on the results of a historical environmental investigation reported elsewhere. There were 189 deaths (151.2 expected), and for rock-wool/slag-wool and glass-wool workers the standardized mortality ratios for lung cancer showed a pattern of increasing mortality with time since first exposure but not duration of employment. There was an excess of lung cancer among rock-wool/slag-wool workers employed during an early technological phase before the introduction of dust-suppressing agents, and fiber exposure, either alone on in combination with other exposures, may have contributed to the elevated risk. No excess of the same magnitude was evident for glass-wool production, and the follow-up of the continuous filament cohort was too short to allow for an evaluation of possible long-term effects. There was no evidence of an increased risk for pleural tumors or nonmalignant respiratory diseases.
mesh_terms: D017610:Calcium Compounds; D003252:Construction Materials / Q000009:adverse effects*; D005060:Europe; D005500:Follow-Up Studies; D005898:Glass; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology; D012306:Risk; D017640:Silicates; D012824:Silicic Acid / Q000009:adverse effects
chemical_list: D017610:Calcium Compounds; D017640:Silicates; C009753:fiberglass; D012824:Silicic Acid; C031293:calcium silicate