[Comparative analysis of the sensitivity to natural killers and macrophages of 3-methylcholanthrene-induced tumors in mice].
The sensitivity of 3 primary and 13 continuous tumour cell cultures 11 of which were induced with 20-methylcholanthrene to natural killer cells and cytotoxic macrophages has been tested. It is shown that the sensitivity of target cells varies markedly to both types of effector cells and that the level of susceptibility correlates with transplantability of tumour cells but not with their growth rate in syngeneic animals. Cells with high or zero transplantable capacity proved to be resistant, while cells with intermediate transplantability were sensitive to nonspecific immunity effector cells.
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D008748:Methylcholanthrene
Sravnitel'nyĭ analiz chuvstvitel'nosti k estestvennym killeram i makrofagam opukholeĭ, indutsirovannykh 3-metilkholantrenom u mysheĭ.