Kinins in cerebrospinal fluid: reduced concentration in spontaneously hypertensive rats.
Rat cerebrospinal fluid contains peptides which displace radiolabeled bradykinin from its specific antibodies. Two peptides which showed the same retention time as kallidin and bradykinin in a reverse phase high pressure liquid chromatography system were detected in cerebrospinal fluid of rats. The concentration of radioimmunologically detected kinins in the cerebrospinal fluid of spontaneously hypertensive rats of the Okamoto strain was lower than that of the Wistar Kyoto control rats.
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006973:Hypertension / Q000134:cerebrospinal fluid; D007705:Kinins / Q000134:cerebrospinal fluid*; D051381:Rats; D011918:Rats, Inbred SHR / Q000134:cerebrospinal fluid*; D011919:Rats, Inbred Strains / Q000134:cerebrospinal fluid*; D011921:Rats, Inbred WKY / Q000134:cerebrospinal fluid*; D013045:Species Specificity
D007705:Kinins