title: Validation of an in vitro assay for the determination of rabies antigen.
abstract: The modified antibody binding test, an in vitro method, was validated by a number of studies and was used as a reliable method for in process controls in the manufacture of rabies vaccines for man and animals over the last 6 years. A calculation was made showing the number of laboratory mice which were not needed for animal experiments because these were substituted by the in vitro method mentioned above.
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D004285:Dogs; D006801:Humans; D051379:Mice; D011819:Rabies Vaccines / Q000592:standards*; D011820:Rabies virus / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D011819:Rabies Vaccines