Joint study on the teratogenic sensitivity of the Pika (Ochotona rufescens rufescens) to selected drugs.
A collaborative study was conducted to investigate the teratological susceptibility of the Pika (Ochotona rufescens rufescens) to selected teratogenic chemicals: cyclophosphamide, 6-mercaptopurine, 5-fluorouracil, 6-aminonicotinamide, actinomycin D, ethylurethan, ampicillin, tetracycline, thalidomide, diphenylhydantoin, hypervitaminosis A, aspirin, dexamethasone, betamethasone and bredinin. Some of the chemicals were shown to be teratogenic in the Pika, but this animal was generally more resistant to their teratogenicity than the rabbit and rodents. In the Pika, thalidomide did not induce any typical limb defects, which have been produced in the rabbit. Pikas reproduce well and appear to have no substantial disadvantages as an animal species for teratological studies. Thus, the Pika may be useful as a new non-rodent species for teratological testings.
D015120:6-Aminonicotinamide / Q000633:toxicity; D000014:Abnormalities, Drug-Induced / Q000662:veterinary*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D007793:Lagomorpha; D008297:Male; D008322:Mammals; D009152:Mutagenicity Tests; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012263:Ribonucleosides / Q000633:toxicity; D014801:Vitamin A / Q000633:toxicity
D012263:Ribonucleosides; D014801:Vitamin A; D015120:6-Aminonicotinamide; C010052:mizoribine; D003520:Cyclophosphamide