Biotransformation of the carcinogen chrysazin by NADPH-microsome system.
The interactions of chrysazin, a carcinogenic anthraquinone, with electron transport systems in microsomes and mitochondria (submitochondrial particles, SMP) were studied. The NADPH-dependent oxygen uptake in microsomes was significantly enhanced by chrysazin and no such effect was observed in the NADH-dependent reactions in microsomes and SMP. The NADPH-microsome system caused a marked alteration in the visible absorption spectrum of chrysazin. These results strongly suggest that chrysazin is biotransformed selectively by the NADPH-microsome system.
D000818:Animals; D000880:Anthraquinones / Q000378:metabolism*; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009249:NADP / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D051381:Rats; D013053:Spectrophotometry
D000880:Anthraquinones; D002273:Carcinogens; D009249:NADP; C004315:danthron