Drug interaction between metoprolol and chlordiazepoxide.
We studied the effect of concomitant administration of chlordiazepoxide on the negative chronotropic effect of metoprolol in rabbits. Chlordiazepoxide administration for more than two weeks partly reversed the effect of metoprolol in three out of five rabbits, probably through hepatic enzyme induction.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects*; D008790:Metoprolol / Q000037:antagonists & inhibitors*; D011817:Rabbits
D002707:Chlordiazepoxide; D008790:Metoprolol