title: Human retinal pigment epithelial cells in the vitreous of the owl monkey.
abstract: Cultured human retinal pigment epithelium was injected into the vitreous of owl monkeys. The epithelial cells were derived from either a foetal or an adult cell line. The five monkeys which were injected with cultured foetal cells developed substantial vitreal membranes and had retinal detachment by 2 weeks, whereas the five monkeys with cultured adult cells did not develop detachments within the period of investigation, and vitreal membranes were insubstantial. An electron-microscopic, immunohistochemical and autoradiographic study was conducted on these eyes to investigate in detail the behaviour and intraocular effects of the injected cells.
mesh_terms: D000328:Adult; D000818:Animals; D001029:Aotus trivirgatus; D002460:Cell Line; D005333:Fetus; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D008566:Membranes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000473:pathology* / Q000648:ultrastructure; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D014822:Vitreous Body / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D005353:Fibronectins