title: Influence of bile salts and lipids on intestinal absorption of griseofulvin in man.
abstract: The influence of bile salts and lipids on the intestinal absorption of griseofulvin has been studied in 11 healthy male volunteers by the intestinal perfusion technique. The drug in a nutrient solution (Realmentyl) was perfused into the second part of duodenum at 5 ml/min. Intestinal samples were taken continuously at 1 ml/min, 20 cm (at the angle of Treitz) and 45 cm distal to the perfusion point. To study the effect of lipids on griseofulvin absorption, the drug was perfused with solutions A and B, of which B contained a total lipid and caloric load three times that of A. The influence of bile salts on griseofulvin absorption was examined by perfusing the drug on Day 1 with bile salts and again on the following day after bile salt depletion. Bile salts and a varying quantity of lipid perfusate had no significant influence on the duodeno-jejunal griseofulvin absorption rate per cm of intestine. Lipids, however, may still play a role in griseofulvin absorption along the entire intestine.
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism / Q000502:physiology*; D004386:Duodenum / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006118:Griseofulvin / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism; D007700:Kinetics; D008055:Lipids / Q000494:pharmacology*; D008297:Male
chemical_list: D001647:Bile Acids and Salts; D005227:Fatty Acids; D008055:Lipids; D006118:Griseofulvin