[Characteristics of the central adrenergic mechanisms regulating arterial pressure in rats with hereditary arterial hypertension].
Adrenergic mechanisms of blood pressure regulation were studied in a newly developed strain of rats with inherited stress-provoked arterial hypertension, spontaneously hypertensive rats (SHR) and normotensive Wistar rats. A number of adrenergic agonists (noradrenaline, adrenaline, phenylephrine, clonidine, naphazoline, isoproterenol, dobutamine, Alupent) were infused into the lateral brain ventricle under nembutal anesthesia and the reaction of the peripheral blood pressure was measured. It was shown that blood pressure reactions were similar in rats with inherited stress-provoked arterial hypertension and in SHR but significantly differed from those of normotensive Wistar rats. The data obtained suggest that the development of inherited hypertension was accompanied by changes in alpha 1 to alpha 2 adrenoreceptor ratio in pressor and depressor brain regions. A decrease in the depressor effect after stimulation of beta 1 and beta 2 receptors has been also observed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D013312:Stress, Physiological / Q000150:complications; D013566:Sympathomimetics / Q000494:pharmacology
D011941:Receptors, Adrenergic; D013566:Sympathomimetics
Osobennosti tsentral'nykh adrenergicheskikh mekhanizmov reguliatsii arterial'nogo davleniia u krys s nasledstvenno obuslovlennoĭ arterial'noĭ gipertenzieĭ.