Protein kinase C activity in platelets from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY).
Calcium-activated phospholipid dependent protein kinase (protein kinase C) activity in platelets was measured in 4, 12, and 20-week-old SHR and WKY. At age 4-weeks, there was no significant difference in protein kinase C activity and systolic blood pressure between SHR and WKY. In 12 and 20-week-old SHR, both protein kinase C activity and systolic blood pressure were significantly higher than in the age-matched WKY. These results suggest that protein kinase C may be involved in the control of blood pressure in SHR and WKY.
D000367:Age Factors; D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D006973:Hypertension / Q000097:blood*; D011493:Protein Kinase C / Q000097:blood*; D011494:Protein Kinases / Q000097:blood; D051381:Rats; D011918:Rats, Inbred SHR / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D011921:Rats, Inbred WKY / Q000097:blood
D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium