[Cortisol and methylprednisolone secretion by the nasal mucosa].
In eight volunteers, blood, saliva and nasal mucus samples are simultaneously collected every two hours from 8.30 a.m. to 22.30 p.m. Next day, after administration of 20 mg alpha-methyl prednisolone per os, the same sample procedure is applied. Cortisol and alpha-methylprednisolone are measured in each biological medium by direct radioimmunoassay. The episodic secretions of nasal mucus cortisol are significantly correlated with those determined in plasma or in saliva. Concerning alpha-methylprednisolone in nasal mucus, its half-life is about two hours and its feed-back effect on the hypothalamo-pituitary-adrenal axis is showed.
D000293:Adolescent; D005260:Female; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008775:Methylprednisolone / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism*; D011863:Radioimmunoassay; D012463:Saliva / Q000032:analysis
D006854:Hydrocortisone; D008775:Methylprednisolone
Sécrétion du cortisol et de la méthylprednisolone par la muqueuse nasale.