title: Single-shot vs conventional therapy with amikacin for treatment of uncomplicated urinary tract infections: a multicenter study.
abstract: Results are discussed of a national Italian survey carried out by 1,689 general practitioners supervised by 112 hospital specialists. The goal of the survey was to check the efficacy and tolerance of single-shot (single dose) treatment of uncomplicated urinary tract infections with amikacin. 22,216 patients were evaluated, over 23,521 treated, and positive results were obtained in 73.7% with single-shot amikacin, 25.6% with conventional therapy with amikacin 15 mg/kg/day X 7 days, resulting in a total effectiveness of 99.3%. Adverse effects (tinnitus, equilibrium disorders, azotemia and creatinine levels higher than standards) were reported in 0.96% of the patients (0.37% in single-shot, 2.63% in conventional treatment). These data indicate that a single dose (single-shot) administration of amikacin can be a rational and advantageous treatment of uncomplicated urinary tract infections.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000583:Amikacin