title: Decreased mononuclear cell response to mitogens in artificially reared neonatal pigs.
abstract: The influence of two rearing methods for neonatal pigs on mononuclear cell responses to mitogens was studied. Littermate pigs were reared artificially or on the sow. Artificially reared pigs displayed a leukocytosis (P less than 0.05) characterized by an increase (P less than 0.05) in mature and immature neutrophils. Skin-test responses to intradermal injections of phytohemagglutinin were less (P less than 0.05) in artificially reared pigs than in sow-reared controls. Lymphocyte proliferative responses to mitogenic stimulation were approximately 50% lower (P less than 0.05) in artificially reared pigs than in sow-reared pigs. These data suggest that artificial rearing lowers in vivo and in vitro lymphocyte responses in neonatal pigs.
mesh_terms: D000704:Analysis of Variance; D000822:Animal Husbandry; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013552:Swine / Q000276:immunology*
chemical_list: D010835:Phytohemagglutinins