Studies on heparin immobilization to collagen.
After activation of carboxyl groups with carbodiimide, heparin binds to collagen by a stable covalent linkage. Covalent binding of heparin to collagen results in enhanced stability of the preparation. Also, heparin bound collagen retains its anticoagulative activity.
D000925:Anticoagulants; D002234:Carbodiimides; D003094:Collagen / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000925:Anticoagulants; D002234:Carbodiimides; D006493:Heparin; D003094:Collagen