Skinned smooth muscle: calcium-calmodulin activation independent of myosin phosphorylation.
In chemically skinned chicken gizzard smooth muscle fibers investigated shortly after preparation, a contraction may be induced by calcium and calmodulin which is independent of myosin phosphorylation at intermediate Ca2+-concentrations. However, fibers stored for a prolonged period also contract in the absence of exogenous calmodulin and exhibit a close relationship between force development and myosin phosphorylation.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology*; D002645:Chickens; D005895:Gizzard, Avian; D066298:In Vitro Techniques; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D009219:Myosin-Light-Chain Kinase / Q000502:physiology; D009218:Myosins / Q000502:physiology*; D010766:Phosphorylation
D002147:Calmodulin; D009219:Myosin-Light-Chain Kinase; D009218:Myosins; D002118:Calcium