title: Gangliocytic paraganglioma associated with duodenal adenocarcinoma. Case report with immunohistochemical evaluation.
abstract: We present the first reported case (to our knowledge) of duodenal gangliocytic paraganglioma (GPG) to be associated with an underlying invasive adenocarcinoma. The patient, a 71-year-old man, presented with epigastric tenderness and was found to have metastatic adenocarcinoma in two regional lymph nodes. Immunohistochemical evaluation of the GPG demonstrated positive staining for gastrin, glial-fibrillary acidic protein, glucagon, neuron-specific enolase, pancreatic polypeptide, S100 protein, somatostatin, and substance P. The clinical, pathologic, and immunohistochemical features of GPG are discussed, with a review of the literature.
mesh_terms: D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology*; D000368:Aged; D004379:Duodenal Neoplasms / Q000032:analysis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000032:analysis / Q000473:pathology*; D010235:Paraganglioma / Q000032:analysis / Q000473:pathology*