Ara-C syndrome during low-dose continuous infusion therapy.
Four patients with acute nonlymphocytic leukemia developed one or more components of the "ara-C syndrome" including fever, peritonitis, pericarditis, and a maculopapular rash during therapy with continuous infusions of low-dose (20 mg/m2/d) cytosine arabinoside (ara-C). These complications, described with standard and high doses of ara-C, have not been previously noted with low-dose regimens.
D000368:Aged; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007262:Infusions, Intravenous; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000139:chemically induced; D010538:Peritonitis / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced; D013577:Syndrome
D003561:Cytarabine