title: [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion].
abstract: It was shown in the experiments with albino rats that legalon and essentiale had a pronounced hepatoprotective effect in tetracycline affections of the liver. They retarded the increase in the activity of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in blood serum, prevented suppression of cholopoiesis by tetracycline and inhibited lipid peroxidation. The drugs may be used for prevention and treatment of tetracycline affections of the liver.
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000627:therapeutic use*; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use*; D013752:Tetracycline / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010713:Phosphatidylcholines; D012838:Silymarin; C011246:essential 303 forte; D013752:Tetracycline
vernacular_title: Effektivnost' legalona i éssentsiale pri porazhenii pecheni tetratsiklinom.