Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor.
Nerve growth factor (NGF) was injected into the lateral ventricle (5 micrograms on 4 occasions) of rats which had previously sustained ibotenic acid-induced lesions of the nucleus basalis of Meynert. Lesioned, but vehicle-injected and sham-lesioned and vehicle-injected rats were run as controls. Infusion of NGF led to a significant recovery of cortical choline acetyltransferase and acetylcholinesterase activity 6 weeks, but not two weeks after the lesion.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia; D001927:Brain Diseases / Q000188:drug therapy / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers; D008297:Male; D009414:Nerve Growth Factors / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata
D009414:Nerve Growth Factors; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase