Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury.
The protective effects of exogenous phospholipid on aspirin-induced gastric mucosal injury were examined in a canine chamber model which provided two separate segments of mucosa supplied by a single vascular pedicle. In each dog, one segment was treated with a suspension of surface-active phospholipid, similar in composition to that normally present in the gastric mucosa, whereas the other segment served as the control. Pretreatment of the test segments significantly prevented aspirin-induced disruption of the mucosal barrier as evidenced by an increase in potential difference and a decrease in acid back-diffusion and sodium ion and potassium ion flux. These findings were associated with a marked reduction in the degree of mucosal injury. Our results support the recent hypothesis that surface-active phospholipid plays an important role in gastric mucosal defense against the damaging effects to luminal acid.
D000818:Animals; D001241:Aspirin / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D010743:Phospholipids / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D011199:Potentiometry; D012964:Sodium / Q000378:metabolism
D010743:Phospholipids; D012964:Sodium; D001241:Aspirin; D011188:Potassium