A new platelet antigen system, Yuka/Yukb.
We report a new platelet antigen (Yukb) involved in a case of neonatal alloimmune thrombocytopenia (NAITP). This antigen is considered to be a product of an allele of the Yuk gene, another allele of which codes for Yuka which was involved in 2 cases of NAITP. The Yuka and Yukb antigens are not expressed on thrombasthenic platelets which suggests that these antigens are present on platelet glycoprotein IIb and/or IIIa. The gene frequencies for Yuka and Yukb in the Japanese population were estimated to be 0.0083 and 0.9917, respectively.
D000483:Alleles; D000954:Antigens, Surface / Q000032:analysis* / Q000235:genetics; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D007564:Japan; D008297:Male; D010375:Pedigree; D010980:Platelet Membrane Glycoproteins / Q000276:immunology; D013915:Thrombasthenia / Q000276:immunology; D013921:Thrombocytopenia / Q000276:immunology*
D000954:Antigens, Surface; D010980:Platelet Membrane Glycoproteins