Indium-111 leukocyte scintigraphy in Wegener's granulomatosis involving the spleen.
Indium-111-labeled leukocyte scintigraphy was performed on a 44-yr-old man to exclude an occult abscess. Four- and twenty-four-hour images of the abdomen revealed splenic photopenia except for a rim of activity medially. A subsequent computed tomography (CT) study demonstrated necrosis or hemorrhage of the spleen except for a medial rim. Exploratory laparotomy demonstrated necrotizing vasculitis with granuloma formation consistent with Wegener's granulomatosis and a rim of viable splenic tissue corresponding to the radionuclide and CT studies.
D000328:Adult; D014890:Granulomatosis with Polyangiitis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007204:Indium; D007962:Leukocytes; D008297:Male; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013158:Splenic Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D011868:Radioisotopes; D007204:Indium