title: [Age-related structural and functional changes in the DNA of human lymphocytes].
abstract: Characteristic changes of DNA winding and repair are detected in human peripheral lymphocytes with advancing donor age between 20 and 90 years, suggesting a progressively undifferentiated cell state. From a model approach it appears likely that the existence of immature lymphocytes favors aging as a general dysdifferentiation of somatic cells.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001482:Base Composition / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000032:analysis*; D004260:DNA Repair / Q000528:radiation effects; D004278:DNA, Superhelical / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D014466:Ultraviolet Rays
chemical_list: D004278:DNA, Superhelical; D004247:DNA
vernacular_title: Altersabhängige strukturelle und funktionelle Veränderungen an der DNA menschlicher Lymphozyten.