title: Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride.
abstract: The relative bioavailability and pharmacokinetics of two orally administered aqueous suspensions of noscapine hydrogen embonate were compared with those of noscapine hydrochloride solution. Noscapine hydrochloride showed faster absorption and gave a higher peak concentration than the embonate. The average bioavailability of the embonates was 71% of that of the noscapine solution (p less than 0.05). No significant difference was observed when the embonate was administered with water, polyvidone and flavouring agents.
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009665:Noscapine / Q000378:metabolism*; D012996:Solutions; D013535:Suspensions
chemical_list: D012996:Solutions; D013535:Suspensions; D009665:Noscapine