Surgical stress inhibits physostigmine-induced pressor effect.
Physostigmine-induced pressor response was studied in adrenalectomized rats. The pressor response to intracerebroventricular administration of physostigmine was found to be inhibited in both acutely adrenalectomized and sham-operated rats, but not in animals adrenalectomized 24 h earlier. Laparatomy performed just before the experiment also inhibited the pressor effect of physostigmine. This inhibition was completely prevented by naloxone pretreatment. Endogenous opioid peptides released as a response to the stress induced by surgical manipulation, could be accounted for inhibition of the pressor effect of centrally administered physostigmine in rats.
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007276:Injections, Intraventricular; D007813:Laparotomy; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
D009270:Naloxone; D010830:Physostigmine