Evidence for anti-inflammatory effect of normal circulating plasma cortisol.
Joint pain and tenderness increased significantly during metyrapone tests in 21 patients with rheumatoid arthritis who had never received corticosteroid therapy and who had no evidence of endocrine disease. This observation implies that the normal circulating plasma corticol exerts an anti-inflammatory effect.
D000893:Anti-Inflammatory Agents; D001172:Arthritis, Rheumatoid / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood* / Q000502:physiology; D006889:Hydroxycorticosteroids / Q000652:urine; D008797:Metyrapone / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D006889:Hydroxycorticosteroids; D006854:Hydrocortisone; D008797:Metyrapone