title: Target cell and mode of radiation injury in rhesus salivary glands.
abstract: Morphological alterations of parotid and submandibular salivary glands of rhesus monkeys were studied 1-72 h and 16-40 weeks postirradiation (PI) with single photon doses of 2.5-15.0 Gy, or 10.2 Gy given in 6 fractions. Acute degeneration and necrosis of serous cells in both parotid and submandibular glands were clearly expressed by 24 h PI and occurred in a dose-related fashion. In submandibular glands, doses of 12.5 or 15.0 Gy damaged mucous cells, but to a considerably lesser extent than the serous cells in the same glands. No significant sparing was evident with dose fractionation. These observations demonstrate the unique sensitivity of serous cells which appear to undergo interphase cell death after irradiation. The results also show that late atrophy was the direct result of acute loss of serous acini and reflects a lack of regeneration of acinar cells receiving acute injury.
mesh_terms: D000818:Animals; D001284:Atrophy; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008253:Macaca mulatta; D009336:Necrosis; D010306:Parotid Gland / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D013363:Submandibular Gland / Q000528:radiation effects*; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes