title: The influence of indomethacin on collagen synthesis during tendon healing in the rabbit.
abstract: The influence of indomethacin on collagen synthesis in intact and healing plantaris longus tendons in the rabbit was investigated. Forty-four male New Zealand White rabbits were subjected to a standardized trauma (tenetomy + repair) on the left hindlimb. Half of the animals were subsequently treated with indomethacin, 10 mg/kg per day orally, and the other half with placebo. After 2 and 4 weeks the rabbits were injected intravenously with 3H-proline and killed 18 h later. Indomethacin affected the collagen metabolism differently depending on whether the tendons were involved in wound healing or not. In intact tendons the drug caused a small general inhibition of collagen synthesis. In the healing tendon there was a shift towards the synthesis of more insoluble collagen with little effect on the total synthesis. After 4 weeks there was also a slight but significant decrease in the amount of hydroxyproline in the most soluble collagen fraction from the tenotomized, indomethacin treated tendons.
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D006909:Hydroxyproline / Q000032:analysis; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D013710:Tendons / Q000378:metabolism / Q000473:pathology*; D014945:Wound Healing
chemical_list: D003094:Collagen; D011392:Proline; D006909:Hydroxyproline; D007213:Indomethacin