Transcriptional activation of the mouse Mx gene by type I interferon.
Mouse cells of the Mx+ genotype accumulate Mx mRNA in response to type I interferon (IFN). Nuclear runoff experiments show that IFN stringently regulates Mx gene expression at the level of transcription. Mx mRNA synthesis peaks about 3 h after IFN treatment, and within 5 h, Mx mRNA concentration rises from undetectable levels to about 0.1% of polyadenylated RNA.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004622:Embryo, Mammalian; D005796:Genes / Q000187:drug effects*; D005809:Genes, Regulator / Q000187:drug effects; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects*
D007370:Interferon Type I; D012333:RNA, Messenger