Delayed childbearing: no evidence for increased risk of low birth weight and preterm delivery.
Prior studies of the effect of increased maternal age on reproductive outcome in primiparous women have often ignored the possible influence on this relation of more frequent histories of spontaneous abortion and infertility in older women. When these histories are taken into account, the present study of 1,382 white primiparous women who had live singleton deliveries at Yale-New Haven Hospital finds no evidence for an increased risk of low birth weight (relative risk (RR) = 1.06, 95% confidence interval (CI) = 0.38-2.94) or preterm delivery (RR = 1.07, 95% CI = 0.50-2.24) in women delivering at age 30 years or more compared with younger women. Mean birth weight (beta = -19 g, p = 0.57) and gestational age (beta = -0.16 weeks, p = 0.34) were also not significantly affected by older maternal primiparity. Women aged 35 years or more had twice the rate of preterm births compared with women under age 30, although this result was not statistically significant in this data set (RR = 2.07, 95% CI = 0.67-6.35). Other confounding variables were taken into account.
D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008423:Maternal Age; D011247:Pregnancy; D012306:Risk; D012907:Smoking