Experimental study of bridging the peripheral nerve gap with skeletal muscle.
A piece of skeletal muscle was used as a conduit to bridge the gap microsurgically between the two ends of the severed sciatic nerve in 30 rats, and a method for histochemical demonstration of acetylcholinesterase was employed to assess the nerve regeneration process 5 weeks or more after the operation. Regenerating nerve fibers were detected in the muscle and could be traced through to the distal stump of the severed sciatic nerve. This suggests that skeletal muscle might serve as a grafting conduit for the repairing of peripheral nerve injuries.
D000818:Animals; D005260:Female; D008297:Male; D009132:Muscles / Q000637:transplantation*; D009416:Nerve Regeneration; D051381:Rats; D012584:Sciatic Nerve / Q000502:physiology / Q000601:surgery*; D013997:Time Factors