title: Components of the electroretinogram: a reappraisal.
abstract: During light adaptation a progressive increase in the intensity of a flash stimulus yields ERGs in which the a-wave shows a gradual reduction in peak time, while the b-wave appears to do the opposite. However, close inspection of the different ERG waveforms indicates that the wave identified as the b-wave for a threshold stimulus actually decreases in peak time with progressively stronger stimulus. Furthermore, what is identified as the b-wave for a threshold stimulus delivered in light adaptation will become a part of the a-wave complex if the same stimulus is used in dark adaptation. Data presented here indicate that the identification of the a- and b-waves of the ERG must be constantly revised according to the intensity of the stimulus and/or the level of retinal adaptation. These findings seriously challenge the validity of the a-b-wave nomenclature currently used in electroretinography. An alternative nomenclature, based on the first derivative (dv/dt) of the ERG wave, is proposed.
mesh_terms: D000221:Adaptation, Ocular; D003623:Dark Adaptation; D004596:Electroretinography; D006801:Humans; D008027:Light