title: Antibacterial activity of phosphono dipeptides related to alafosfalin.
abstract: A series of dipeptides containing N-terminal alanine or leucine and a wide range of P-terminal racemic 1-amino-alkanephosphonates were prepared and tested in vitro for their ability to inhibit the growth of various bacterial species. The results demonstrate that peptides containing 4-amino-4-phosphonobutyric acid and 1-amino-1-methylethanephosphonic acid exhibit antibacterial activity comparable with that observed in the case of peptides containing P-terminal racemic 1-aminoethanephosphonic acid (analogue of alanine) used as a positive control.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004151:Dipeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; C006437:alafosfalin; D000409:Alanine