Anticonvulsant effects of ivermectin in genetically-epileptic chickens.
In genetically-photosensitive epileptic chickens, the anti-parasitic agent ivermectin, at 1.0 and 5.0 mg/kg, decreased or prevented seizures induced by intermittent photic stimulation without any side-effects on the central nervous system. The latency and duration of this anti-convulsant effect was dose-dependent. When combined with diazepam, ivermectin prolonged the anti-convulsant action of diazepam.
D000818:Animals; D000927:Anticonvulsants; D002645:Chickens / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology / Q000662:veterinary*; D007559:Ivermectin / Q000494:pharmacology*; D009154:Mutation; D010775:Photic Stimulation; D011201:Poultry Diseases / Q000235:genetics* / Q000503:physiopathology
D000927:Anticonvulsants; D007559:Ivermectin; D003975:Diazepam