title: Long-term clinical investigation of the hepatobiliary agents: 99mTc-HIDA and 99mTc-p-butyl-IDA.
abstract: The organ distribution data for the two hepatobiliary agents HIDA and p-butyl-IDA in mice showed substantial differences in the extent and rate of hepatobiliary clearance of radioactivity. 99mTc-HIDA and 99mTc-p-butyl-IDA were used in computer assisted serial hepatobiliary scintigraphy. In normal subjects, the data of dynamic studies showed that the kidneys were no longer seen after 2.5 min with p-butyl-IDA. Liver radioactivity decreased significantly after 10 min with HIDA compared to 35 min with p-butyl-IDA. The gall bladder was always visualized at the 10-12th min and the 25-30th min with HIDA and p-butyl-IDA respectively. 99mTc-HIDA provided superior hepatic duct images.
mesh_terms: D000818:Animals; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D007098:Imino Acids / Q000097:blood; D007668:Kidney / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D051379:Mice; D015609:Organotechnetium Compounds; D011485:Protein Binding; D011877:Radionuclide Imaging; D013667:Technetium / Q000097:blood; D019780:Technetium Tc 99m Lidofenin
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium