title: Prototype of a new protamine sulphate titration kit for use in cardiopulmonary bypass surgery.
abstract: A new protamine sulphate titration kit has been developed and tested in patients undergoing cardiac bypass surgery. When a prototype of the kit was used, protamine sulphate dosage was significantly reduced (P less than 0.01) without a significant increase in 24-hour postoperative blood loss (P greater than 0.05).
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass; D005069:Evaluation Studies as Topic; D006494:Heparin Antagonists / Q000032:analysis / Q000627:therapeutic use; D006801:Humans; D011479:Protamines / Q000032:analysis* / Q000627:therapeutic use; D011897:Random Allocation; D011933:Reagent Kits, Diagnostic / Q000592:standards*
chemical_list: D006494:Heparin Antagonists; D011479:Protamines; D011933:Reagent Kits, Diagnostic