title: [Infectious endocarditis: its resistance to therapy, causative factors and means of combating it].
abstract: Based on the data obtained during observation over 270 patients with infectious endocarditis the authors discuss factors that cause antibacterial therapy resistance encountered particularly often over the recent decade. Among the factors, the authors mark polyetiology of the disease over the recent years, "new" patterns of endocarditis in terms of the pathogenesis, predominance of primary endocarditis with highly virulent microorganisms, late disease diagnosis, inadequate antibacterial treatment, and so forth. Approaches to overcoming treatment resistance are also considered.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D004696:Endocarditis / Q000188:drug therapy* / Q000209:etiology; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Infektsionnyĭ éndokardit--rezistentnost' k terapii, obuslovlivaiushchie ee faktory i puti preodoleniia.