Effects of methamphetamine on arterioles of rat caudate nucleus and midbrain.
No differences in arteriolar metabolic profiles from rat caudate nucleus, ventral tegmental area or substantia nigra were observed between saline-control and methamphetamine HCl-treated (20 mg/kg, i.p. twice daily for 10 consecutive days) animals. Arterioles from the above regions of forebrain and midbrain are metabolically active vessels with a capacity for aerobic and anaerobic metabolism. These results suggest that a high dose of methamphetamine does not alter cerebral arteriolar metabolism in the areas examined.
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000378:metabolism; D002421:Caudate Nucleus / Q000098:blood supply*; D008297:Male; D008636:Mesencephalon / Q000098:blood supply*; D008694:Methamphetamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008694:Methamphetamine