Prevalence of the fragile X syndrome in an institution for the mentally handicapped.
In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down's syndrome as a known cause for mental handicap.
D000328:Adult; D005260:Female; D005600:Fragile X Syndrome / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D006778:Hospitals, Psychiatric; D006801:Humans; D007360:Intelligence; D008297:Male; D012729:Sex Chromosome Aberrations / Q000453:epidemiology*; D013733:Testicular Diseases / Q000150:complications; D013737:Testis / Q000473:pathology