title: Genealogical memory to perinatal iodine-131 exposure in rats: I. Alteration in natural immunity.
abstract: A heritable alteration in the natural immunity as measured by changes in the natural killer (NK) cell activities of peripheral blood lymphoid-cells was found to occur in rats upon an in utero exposure to iodine-131. The model that was employed for the measurements consisted of Fischer F344 inbred rats exposed to iodine-131 (sodium) during their 16th to 18th day of gestation. The natural immunity of the animals was evaluated by determining the NK cell activities of peripheral blood lymphoid cells of the offsprings when they reached 2 months of age. Immediately following determination of the natural immunity, brother and sister matings were carried out for evolution of the families. Study of these pedigrees revealed an impairment in the natural immunity to persist through two generations (F1, and F2) of the male animals. The hematological profiles of the animals suggest that the insult may alter the numbers of red and white blood cells in the succeeding generations, but has little noticeable effect upon the percentage of lymphocytes. The interpretation of the results indicate that a perinatal insult by iodine-131 during late gestation can result in both somatic and germ cell changes in the immunological system. Thus, there appears to be a genealogical memory to an in utero radionuclide insult which may adversely affect the offspring's immunological competency to respond to subsequent insults.
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002470:Cell Survival / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D007111:Immunity, Cellular; D007113:Immunity, Innate / Q000187:drug effects*; D007457:Iodine Radioisotopes / Q000633:toxicity*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008433:Mathematics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011916:Rats, Inbred F344 / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics*
chemical_list: D007457:Iodine Radioisotopes