title: The blood flow velocity waveform in the fetal descending aorta; its relationship to behavioural states in the growth-retarded fetus at 37-38 weeks of gestation.
abstract: In 12 patients with intrauterine growth retardation (IUGR), the relationship between the blood flow velocity waveform at the lower thoracic level of the fetal descending aorta and fetal behavioural states at 37-38 wk of gestation was studied. A significant inverse relationship (P less than 0.001) was established between pulsatility index (PI) and fetal heart rate (FHR) in state 1F and 2F. The PI as a measure of peripheral vascular resistance, demonstrated a marked increase compared to normal pregnancy. There is a virtual overlap of PI values originating from state 1F and 2F according to the classification by Nijhuis et al. (J.G. Nijhuis, H.F.R. Prechtl, C.B. Martin, Jr. and R.S.G.M. Bots (1982) Early Hum. Dev. 6, 177-195). The peripheral vasoconstriction present in IUGR seems to overrule state dependent PI fluctuations. The marked rise in PI, particularly at lower FHR and the constancy of PI in relation to fetal behavioural states can be considered vascular adaptations, which are instrumental in the centralization of the fetal circulation, with the aim of favouring blood supply to the brain, heart and adrenals during IUGR.
mesh_terms: D001013:Aorta, Thoracic; D001783:Blood Flow Velocity; D001794:Blood Pressure; D005133:Eye Movements; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology* / Q000523:psychology; D005324:Fetal Movement; D006339:Heart Rate; D006801:Humans; D011247:Pregnancy; D011674:Pulse; D014655:Vascular Resistance