[Hypercholesterolemia in patients with hypertension and diabetes mellitus. The need for cholesterol control in the prevention of ischemic heart disease].
Between 1980 and 1985, a total of seven hypertension intervention studies were published. The present report reviews the associations between cholesterol levels and their influence on the incidence of coronary heart disease among these hypertensive patients. It can be demonstrated that coronary heart disease in hypertensives may not be reduced even with good blood pressure control as long as cholesterol levels are not normalized. Examples are the Oslo Study, the International Prospective Primary Prevention Study in Hypertension and the British Medical Research Council Study. A low-normal cholesterol level is an essential requirement of successful prevention of coronary heart disease among hypertensive patients. Autopsy studies in diabetics have shown a lack of evidence of coronary heart disease in diabetic patients in Afro-Asian countries in contrast to diabetics in Western industrialized nations, where 40% have died with significant coronary heart disease. Therefore, normalization of cholesterol values in diabetics is a cornerstone of treatment of diabetes mellitus.
D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications*; D006973:Hypertension / Q000097:blood / Q000150:complications*; D009203:Myocardial Infarction / Q000517:prevention & control; D012306:Risk
D002791:Cholesterol, Dietary; D002784:Cholesterol
Hypercholesterinämie bei Patienten mit Hypertonie und Diabetes mellitus. Notwendigkeit der Cholesterinkontrolle zur Verhütung der ischämischen Herzerkrankung.