Circulating transferrin receptor in human serum.
Circulating transferrin receptor has been detected in human serum with a sensitive immunoassay. The mean concentrations of the serum transferrin receptor in healthy males and females were 251 +/- 94 (mean +/- SD) ng/ml and 256 +/- 99 ng/ml, respectively. The serum receptor concentration in patients with haematological malignancies, including acute leukaemia, multiple myeloma and malignant lymphoma, varied widely, from normal to 1100 ng/ml. A single band with an approximate molecular weight between 80,000 and 100,000 daltons was obtained by polyacrylamide gel electrophoresis-immunoblotting analysis of serum.
D000208:Acute Disease; D000328:Adult; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood; D008223:Lymphoma / Q000097:blood; D008297:Male; D008970:Molecular Weight; D009101:Multiple Myeloma / Q000097:blood; D011863:Radioimmunoassay; D011990:Receptors, Transferrin / Q000378:metabolism*
D011990:Receptors, Transferrin