Effect of sixth component of complement on the prostaglandin E1 stimulated adenyl cyclase activity in rat calvaria.
Human serum enhanced the PGE1 stimulated adenyl cyclase activity in membrane rich fraction of rat calvaria, but heated serum did not. Human C6 enhanced the PGE1 stimulated adenyl cyclase activity. C6 did not enhance the PTH stimulated adenyl cyclase activity. The enhancement of the PGE1 stimulated adenyl cyclase activity with C6 was due to increasing Vmax. The enhancement of the enzyme activity with C6 was significantly inhibited with anti-C6 antibody. Adenyl cyclase was not activated with C6 alone.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000201:enzymology; D003183:Complement C6 / Q000502:physiology*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats
D003183:Complement C6; D010281:Parathyroid Hormone; D000262:Adenylyl Cyclases; D000527:Alprostadil