Investigation of dressings developed for the treatment of alveolitis sicca dolorosa. Part 2: Influence of glycerol and PEG 200 on the properties of tablets and dressings comprising mefenamic acid and Nipagin P.
Some hydrogel dressings have been investigated to determine their utility for the treatment of painful dry tooth-socket (Alveolitis sicca dolorosa). As drugs mefenamic acid and Nipagin P have been applied. Hydrophilized methylcellulose, 5-15% glycerol or 5-20% PEG 200 were the filling and gel building material. It has been found, that the properties of the dressings depend on the content of the hydrophilizers. The half liberation time of the drugs under study ranges from 0.5 to 11 h, the swelling degree amounts to 366-400%, the washing out time runs to 80-140 min and the period of activity of the dressings inside the tooth-socket amounts to 24-48 h. The dressings show thixotropic properties and a high flow limit.
D001458:Bandages; D001682:Biological Availability; D005891:Gingivitis / Q000628:therapy*; D005990:Glycerol / Q000627:therapeutic use*; D006801:Humans; D008528:Mefenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D010226:Parabens / Q000008:administration & dosage / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D012212:Rheology; D013607:Tablets
D010226:Parabens; D013607:Tablets; D008528:Mefenamic Acid; D011092:Polyethylene Glycols; C015358:methylparaben; D005990:Glycerol