Conjugation behaviour of different monoclonal antibodies to f-methionyl-leucyl-phenylalanine.
Monoclonal antibodies (moab) are potentially useful carriers for the targeting of effector substances into tumors. Conjugation of the chemotactic peptide f-Met-Leu-Phe (fMLP) to tumor-directed antibodies yields compounds active in vitro and in vivo. The present experiments examine the conjugation of fMLP to four different moab iso- and idiotypes. Molar coupling rations and chemotactic activity are not dependent on the moab species used for conjugation.
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G; D009000:Monocytes / Q000187:drug effects / Q000502:physiology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000276:immunology / Q000494:pharmacology; D014316:Tritium
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D014316:Tritium; D009240:N-Formylmethionine Leucyl-Phenylalanine