[Chromosome segregation in mice heterozygous for Robertsonian translocations. II. Changes in the structure of homologs as a cause of abnormal disjunction in females].
It was demonstrated that mutations T, Fu, Ki, t6 of chromosome 17 cause preferential transmission of the acrocentric homologues to the progeny from female Rb heterozygotes. The results indicate that the effects of these mutations on segregation are restricted to the Robertsonian translocations involving chromosome 17. Substitution of the parts of chromosome 17 distal or proximal to the T-locus did not alter the effect, of this chromosome on the transmission rate of the homologue. The transmissions effects of these mutations, whether cis or trans with Rb, were the same. It was observed that mothers Rb7/T43H transmitted the chromosome with the reciprocal translocation T43H to 70.9% of their progeny. Data were obtained supporting the idea that structural changes of the chromosomes caused by mutations affect segregation of the homologues in Rb heterozygous females. The possible mechanism of this influence is discussed.
D000818:Animals; D005260:Female; D006579:Heterozygote; D051379:Mice; D009154:Mutation; D009630:Nondisjunction, Genetic; D011995:Recombination, Genetic; D014178:Translocation, Genetic
Segregatsiia khromosom u mysheĭ, geterozigotnykh po robertsonovskim translokatsiiam. Soobshchenie II. Izmenenie struktury gomologov kak prichina anomal'nogo raskhozhdeniia u samok.