Azinomycins A and B, new antitumor antibiotics. I. Producing organism, fermentation, isolation, and characterization.
A strain of Streptomyces griseofuscus S42227 (FERM P-8443) was found to produce new antitumor antibiotics, called azinomycins A and B. The molecular formulas of azinomycins A and B were determined as C30H33N3O10 and C31H33N3O11, respectively. They were active against Gram-positive bacteria, Gram-negative bacteria and L5178Y cells in tissue culture.
D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D006020:Glycopeptides / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D036341:Intercellular Signaling Peptides and Proteins; D007940:Leukemia L5178 / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes; D010455:Peptides; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D006020:Glycopeptides; D036341:Intercellular Signaling Peptides and Proteins; D009281:Naphthalenes; D010455:Peptides; C051055:azinomycin B