Serological analysis of H-2 antigens expression on the cell surface of drug- and lectin-resistant mouse tumor cells.
The results of studies on the H-2 antigens expression on L1210 and P388 mouse lymphoma cells and their drug-resistant sublines as well as on Lewis lung carcinoma (LL2) cells and their wheat germ agglutinin-resistant variants (LL(2)5 and LL(2)8) are presented. The results revealed no qualitative alterations in H-2 antigens expression on cells of L1210 and P388 leukemias and their drug-resistant sublines. However, as determined by cytotoxic assay the increase relative to parental lines in the expression of normal H-2d antigens on cells of both drug-resistant sublines was observed. Using quantitative absorption assay in addition to differentiate quantitative expression of normal H-2b antigens, the presence of alien H-2k and H-2d specificities on lectin-resistant cells of Lewis lung carcinoma was detected.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D004351:Drug Resistance; D006183:H-2 Antigens / Q000032:analysis*; D006239:Haplotypes; D037102:Lectins / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000276:immunology* / Q000473:pathology; D007941:Leukemia P388 / Q000276:immunology* / Q000473:pathology; D007942:Leukemia, Experimental / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology; D014909:Wheat Germ Agglutinins / Q000494:pharmacology
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006183:H-2 Antigens; D037102:Lectins; D014909:Wheat Germ Agglutinins