Antifertility activity and toxicity of alpha-chlorohydrin aromatic ketal analogues in male rats.
The antifertility activity and toxicity of alpha-chlorohydrin and seven aromatic ketal derivatives were investigated in male rats. At a dose of 5 mg/kg injected intraperitoneally each day for 14 days, alpha-chlorohydrin and the methoxy benzaldehyde derivative (compound 2) produced complete infertility. The benzaldehyde derivative (compound 1) was 89% effective and the other five compounds 71-25% effective. All compounds except the least effective antifertility agent, the methylbenzaldehyde derivative (compound 3), reduced the motility of sperm recovered from the epididymis. None of the compounds caused a decrease in body or testes weight but some increased adrenal weight.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002728:Chlorohydrins / Q000494:pharmacology*; D003272:Contraceptive Agents, Male; D004353:Drug Evaluation, Preclinical; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013081:Sperm Motility / Q000187:drug effects; D000517:alpha-Chlorohydrin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity
D002728:Chlorohydrins; D003272:Contraceptive Agents, Male; D000517:alpha-Chlorohydrin