Albumin as one-way transport vehicle into sites of inflammation.
Intravenously injected Evans blue combines with albumin. The resulting complex appears in the inflammatory exudate that collects in Sephadex G 200 subcutaneously injected into rats. A comparison between the concentrations of albumin and Evans blue in the blood and in the inflammatory exudate shows that the life-span of albumin in the Sephadex is drastically reduced. After decomposition of albumin, the combined Evans blue is liberated, accumulates in the Sephadex and, after 24 h, attains concentrations higher than in the blood. The experiment is a plausible model for transport and deposition of albumin-bound drugs into and at sites of inflammation.
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D005070:Evans Blue / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D014677:Pharmaceutical Vehicles; D051381:Rats; D011919:Rats, Inbred Strains
D000418:Albumins; D014677:Pharmaceutical Vehicles; D005070:Evans Blue