[Effect of anesthetics on porphyrin-sensitized photodamage of cells].
The ability of a positively charged local anesthetic dibucain introduced into cell suspension prior to its irradiation to accelerate porphyrin-sensitized photodestruction of different cells is shown. Neutral anesthetics benzocain and ethanol had no such effect. There has been obtained evidence that the dibucain-induced increase in the amount of cell-bound sensitizer plays an essential role in the acceleration of photodestruction.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002175:Candida / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000187:drug effects; D006414:Hematoporphyrin Photoradiation; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D010782:Photolysis; D011166:Porphyrins / Q000494:pharmacology*; D013552:Swine
D000779:Anesthetics, Local; D011166:Porphyrins
Vliianie anestetikov na sensibiliziruemoe porfirinami fotopovrezhdenie kletok.