Premature centromere division dominantly inherited in a subfertile family.
An increased frequency of mitoses showing premature centromere division (PCD) in every chromosome was found in lymphocyte cultures from four members of a subfertile family. These cells were observed in both the presence and absence of colchicine. Cultured fibroblasts from the proband showed only normal diploid metaphases. PCD cells seemed to have a shorter cell cycle. The anomaly was transmitted in a way compatible with autosomal dominant inheritance in this family.
D002478:Cells, Cultured; D002503:Centromere / Q000187:drug effects / Q000648:ultrastructure*; D002875:Chromosomes / Q000648:ultrastructure*; D003078:Colchicine / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005799:Genes, Dominant; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology*; D008297:Male
D003078:Colchicine