Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.
Nuclear microinjection of c-H-ras DNA induced DNA synthesis in reversibly nonproliferating quiescent human cells. The proto-oncogene and oncogene forms were equally effective inducers. In contrast, c-H-ras DNA either alone or in combination with the adenovirus E1A gene did not cause terminally nondividing senescent cells to synthesize DNA.
D000256:Adenoviridae / Q000235:genetics; D004247:DNA / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008845:Microinjections; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D004247:DNA