Synthesis and antimicrobial activity of a new penem, sodium (5R,6S)-2-(2-fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3- carboxylate.
The synthesis and in vitro antimicrobial activity of a new penem antibiotic, sodium (5R,6S)-2-(2-fluoroethylthio)-6-[(1R)-1-hydroxyethyl]penem-3-ca rbo xylate (1), are reported. The MIC values of 1 are compared with those of some related 2-haloalkylthio penems prepared in this work, and also Sch 29482 and thienamycin.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007769:Lactams; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007769:Lactams; D013845:Thienamycins; C033922:Sch 29482; C051057:2-(2-fluoroethylthio)-6-(1-hydroxyethyl)penem-3-carboxylate; C015537:thienamycin