Probenecid potentiates the hyperglycaemic effect but reduces the diuretic effect of frusemide in mice.
The effect of probenecid on frusemide-induced diuresis and hyperglycaemia was studied in mice. Probenecid, a known inhibitor of tubular secretion of organic anions in the kidney, strongly reduced the diuretic response to frusemide (25 or 200 mg kg-1 body weight). This effect of probenecid appeared to be dose-dependent up to 240 mg kg-1 body weight, at least at the lower concentration of frusemide. Pretreatment with probenecid (240 mg kg-1 body weight) potentiated the hyperglycaemic effect of frusemide (25 or 200 mg kg-1 body weight). The results show that probenecid has opposite effects on frusemide-induced diuresis and hyperglycaemia in mice. It is suggested that the acute hyperglycaemic effect of frusemide is not directly linked to diuresis.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004232:Diuretics / Q000037:antagonists & inhibitors*; D004357:Drug Synergism; D005260:Female; D005665:Furosemide / Q000037:antagonists & inhibitors*; D006029:Glycosuria / Q000652:urine; D006943:Hyperglycemia / Q000139:chemically induced*; D051379:Mice; D011339:Probenecid / Q000494:pharmacology*
D001786:Blood Glucose; D004232:Diuretics; D005665:Furosemide; D011339:Probenecid