title: Fournier's syndrome of urogenital and anorectal origin. A retrospective, comparative study.
abstract: Twenty-eight patients with genital and perianal necrotizing infections are described. The patients were divided into three groups according to the primary site of infection: group 1, anorectal (14 patients); group 2, urologic (ten patients), and group 3, idiopathic (four patients). The overall mortality was 25 percent, 28.5 percent for the anorectal group and 10 percent for the urologic group, although this difference is not statistically significant. Necrotizing infections of anorectal origin were more severe and had a less typical way of presentation, with subsequent delay in diagnosis and a higher rate of myonecrosis. As a consequence, more debridements and more fecal derivations had to be performed. The etiologic agents were the same among the three groups and comprised a number of anaerobes (Bacteroides spp, gram-positive cocci) as well as aerobes (microorganisms belonging to the Enterobacteriaceae and S. faecalis). Necrotizing fasciitis was the pathologic picture of nine of ten patients with Fournier's gangrene of urogenital origin and seven of 14 with an anorectal source. Synergistic necrotizing cellulitis was identified in half of those secondary to anorectal origin and only one of those with a urologic source.
mesh_terms: D000328:Adult; D000368:Aged; D001004:Anus Diseases / Q000473:pathology*; D005260:Female; D005734:Gangrene / Q000150:complications; D005831:Genital Diseases, Female / Q000473:pathology*; D005832:Genital Diseases, Male / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012002:Rectal Diseases / Q000473:pathology*; D012189:Retrospective Studies; D013577:Syndrome; D014570:Urologic Diseases / Q000382:microbiology / Q000473:pathology