[Lowering the complement-fixing capacity and induction of tolerogenic properties in human globulins by urea treatment].
Deaggregation of human globulin by the treatment with urea solution has been studied. Urea treatment resulted in dose-dependent lowering of complement fixing globulin capacity. The optimal urea dose was 0.12 M for 10 mg/ml of protein. Deaggregated globulin was stable and tolerogenic in the experiments on mice.
D000818:Animals; D003168:Complement Fixation Tests; D004355:Drug Stability; D006801:Humans; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000187:drug effects* / Q000276:immunology; D007251:Influenza, Human / Q000517:prevention & control; D051379:Mice; D014508:Urea / Q000494:pharmacology*
D007136:Immunoglobulins; D014508:Urea
Snizhenie antikomplementarnosti i pridanie tolerogennykh svoĭstv chelovecheskomy globulinu putem obrabotki mochevinoĭ.