Pulmonary and hepatic lesions in experimental 3-hydroxymethylindole intoxication.
Histopathological examination of liver and lung in guinea pigs experimentally intoxicated by 3HMI, a degradation product of an allelochemic of Brassica spp, showed the harmful effects of this compound on these organs. The 3HMI produces a hepatic steatosis and interstitial pneumonia with septal hyperemia. These results suggest that the 3HMI could develop a synergic toxic action together with skatole (3MI) as inducing agents of different forms of some diseases detected in cattle grazing Brassica pasture.
D000818:Animals; D001937:Brassica / Q000032:analysis*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D006168:Guinea Pigs; D007211:Indoles / Q000633:toxicity*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D007211:Indoles; C016517:indole-3-carbinol