[Ultrastructural changes in the microcirculatory bed and filtration-reabsorption barrier of the kidney during temporary ischemia after unilateral nephrectomy].
Ultrastructure of cellular elements of the microcirculatory bed and filtration-reabsorption barrier has been studied in 150 mature white rats, in which vascular fasciculus of the left kidney has been compressed for 30 min, 1-2 h with a subsequent restoration of the blood stream in the organ undergone ischemia on the 3rd, 7th, 14th, 30th, 60th, 180th, 360th days under conditions of the preliminarily right kidney nephrectomy. On the 3rd day after ischemia of the remained kidney for 30 min, structural components of the walls of the glomerular arterioles and those of the filtration-reabsorption barrier undergo certain ultrastructural changes, that with time elapsed (7, 14 days) gradually pass away, and amount of cells with hypertrophic processes increases. Ischemia for 1 h in the remained kidney with subsequent restoration of the blood stream on the 3rd, 7th days produces in the structures mentioned more pronounced destructive changes. During subsequent compensatory hypertrophy (the 30th, 60th days) of the remained kidney after its ischemia, in the microcirculatory bed elements and in the convoluted canal epitheliocytes intracellular regenerative and hyperplastic processes develop. However, ischemia for 2 h in the remained kidney produces severe destructive-necrotic phenomena in ultrastructure of the microcirculatory bed and of the filtration-reabsorption barrier.
D000818:Animals; D005260:Female; D006984:Hypertrophy; D007511:Ischemia / Q000473:pathology*; D007668:Kidney / Q000098:blood supply*; D007678:Kidney Glomerulus / Q000648:ultrastructure; D007684:Kidney Tubules / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009392:Nephrectomy / Q000009:adverse effects*; D009940:Organoids / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
Ul'trastrukturnye izmeneniia mikrotsirkuliatornogo rusla i fil'tratsionno-reabsorbtsionnogo bar'era pocheki pri ee vremennoĭ ishemii posle odnostoronneĭ nefréktomii.