title: Idiopathic linear glomerular IgA deposition.
abstract: Linear deposition of IgA immunoglobulin was found along the glomerular basement membrane in two patients with normal renal function and no pulmonary abnormalities. One patient had recurrent gross hematuria and a mild focal proliferative glomerulonephritis without deposits on electron microscopy; the second patient had a renal cell carcinoma. This observation of linear IgA antibody deposition in the absence of Goodpasture's syndrome or diabetes mellitus extends the spectrum of diseases associated with glomerular basement membrane-IgA deposition.
mesh_terms: D000293:Adolescent; D000368:Aged; D001485:Basement Membrane / Q000276:immunology; D002292:Carcinoma, Renal Cell / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology; D007680:Kidney Neoplasms / Q000276:immunology*; D008297:Male; D008856:Microscopy, Fluorescence
chemical_list: D007070:Immunoglobulin A