Postnatal changes in the distribution and elemental composition of Paneth cells in normal and corticosteroid-treated rats.
Paneth cells containing zinc-rich granules were found in the small intestine of 6-day-old rats. These cells were more numerous in older animals and were consistently most common in the distal ileum. The zinc content of granules from 10-day-old rats was similar to that found in adults (ca 300 mg atoms/kg dry weight) but no calcium could be detected. An injection of cortisone acetate at 5 days resulted in a premature increase in the numbers of Paneth cells in 10-day-old rats. The cell granules contained normal, adult levels of zinc, a calcium concentration of ca 400 mg atoms/kg dry weight and also an increased concentration of phosphorus.
D000375:Aging; D000818:Animals; D003348:Cortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005612:Freeze Drying; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000378:metabolism*
D015032:Zinc; D003348:Cortisone