Immunogenicity of oil-based contagious bovine pleuropneumonia vaccine in cattle.
The effects on the immunity in cattle of dosage and storage of oil-based inactivated vaccine incorporating the Gladysdale strain were examined. Storage at 4 degrees C for 12 or 24 months was found not to have any marked effect on the immunity conferred in the vaccinated cattle. A dosage of 0.5 ml was found to be as effective as dosages at 1 and 2 ml of the inactivated vaccine. To assess the potency of the inactivated vaccine in cattle two methods were used: antibody response to the vaccine using the complement fixation test and the challenge test in cattle by contact using a virulent strain at 2 and 6 months after vaccination.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000302:isolation & purification; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D004306:Dose-Response Relationship, Immunologic; D009174:Mycoplasma / Q000276:immunology*; D009175:Mycoplasma Infections / Q000662:veterinary*; D011002:Pleuropneumonia, Contagious / Q000517:prevention & control*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000302:isolation & purification
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated