Rate of synthesis of IgG within the blood-brain barrier and the IgG index compared in the diagnosis of multiple sclerosis.
Receiver-operating characteristic curves of the IgG synthesis rate and the IgG index show that the IgG index has better discriminating properties with respect to multiple sclerosis. This, added to the fact that the precision of determining the index is much higher than that of the synthesis rate, makes the IgG index the parameter of choice in the diagnosis of multiple sclerosis.
D001812:Blood-Brain Barrier; D005189:False Positive Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000276:immunology*; D012709:Serum Albumin / Q000032:analysis / Q000134:cerebrospinal fluid; D013223:Statistics as Topic
D007074:Immunoglobulin G; D012709:Serum Albumin