The effect of luminal pH on large intestinal absorption in ulcerative proctocolitis.
The sensitivity of large intestinal absorption to pH and the absorption of short-chain fatty acids were measured in ulcerative proctocolitis by a dialysis bag method. Lowering luminal pH from 7 to 5.5 significantly reduced absorption of salt and water in proctocolitis, but not in normal controls. Short-chain fatty acid absorption was not affected by inflammation or change in pH when patients with ulcerative proctocolitis were compared with controls.
D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005766:Gastrointestinal Contents / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007420:Intestine, Large / Q000378:metabolism*; D008297:Male; D008722:Methods; D008875:Middle Aged
D005227:Fatty Acids