Behavioral and histological effects of acrylamide in rainbow trout.
A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005880:Gills / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D009420:Nervous System / Q000187:drug effects; D012487:Salmonidae / Q000502:physiology*; D014337:Trout / Q000502:physiology*; D014874:Water Pollutants, Chemical / Q000633:toxicity
D000178:Acrylamides; D014874:Water Pollutants, Chemical; D020106:Acrylamide