title: Adenocarcinoma with neuroendocrine differentiation of the urinary bladder. Clinicopathologic, immunohistochemical, and ultrastructural study.
abstract: We describe a primary mixed adenocarcinoma-neuroendocrine carcinoma of the urinary bladder of probable urachal origin. Neuroendocrine differentiation was confirmed by ultrastructural (neurosecretory granules) and immunohistochemical studies (chromogranin and neuron-specific enolase). Two local recurrences and multiple metastases consisted exclusively of the neuroendocrine component. The patient died 30 months after diagnosis with widely metastatic neuroendocrine carcinoma.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology*; D000951:Antigens, Neoplasm / Q000032:analysis; D002277:Carcinoma / Q000276:immunology / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D007120:Immunochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D014497:Urachus / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm