title: Two-disease locus model: sib pair method using information on both HLA and Gm.
abstract: An adaptation of the sib pair method is given for testing the independence of transmission of Gm and the disease, using variable X (which gives information on the phenotypic identity of a sib pair for Gm). Then the joint distribution of IBD for HLA and X for Gm among affected sib pairs was derived under different two-locus models (multiplicative and other) in which one locus is strictly linked to HLA and the other to Gm. We also propose a test for a joint effect of HLA and Gm and whether this effect is multiplicative or not.
mesh_terms: D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic; D011336:Probability
chemical_list: D006680:HLA Antigens; D007126:Immunoglobulin Allotypes