[Effect of various sclerosing drugs on the rat esophagus].
The sclerosing effect of injections of ethoxysklerol, phenol-almondoil, and 10% NaCl-solution into the esophageal walls of 64 wistar-rats was histologically investigated after 2 days, 1 week, 3 weeks, and 4 months. Inflammatory reaction and subsequent sclerosis were of the same kind with all substances. Nevertheless ethoxysklerol showed a slight dependence on concentration. Injection of phenol-almondoil resulted in a less diffuse inflammation than the aqueous solutions. But after 4 months all cases exhibited the same patchy sclerosis despite of the solution used. Our findings and those of the literature allow the conclusion that the sclerosing effect is less dependent from the inflammation-inducing substance itself but from its concentration and localization.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004941:Esophagitis / Q000139:chemically induced; D004947:Esophagus / Q000187:drug effects*; D008297:Male; D009336:Necrosis; D010636:Phenols / Q000633:toxicity; D010938:Plant Oils / Q000633:toxicity; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012597:Sclerosing Solutions / Q000633:toxicity*
D010636:Phenols; D010938:Plant Oils; D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols; D003094:Collagen
Zur Wirkung unterschiedlicher Sklerosierungsmittel auf den Rattenösophagus.