title: Chewing-gum preservative induced toxidermic vasculitis.
abstract: This paper reports the case of a young female patient who presented with a cutaneous urticarial disseminated eruption. Drug-induced side effects were eliminated, and the only recent dietary change was the regular use of chewing-gums containing chlorophylla (E140), menthol and BHT (butylhydroxytoluene). Immunohistological analysis of a cutaneous lesion revealed signs of vasculitis. Within 1 week after stopping chewing gum, the eruption subsided. Oral provocation tests at 4-day intervals confirmed the responsibility of BHT by the reinduction of the cutaneous signs after a few hours.
mesh_terms: D000328:Adult; D002084:Butylated Hydroxytoluene / Q000276:immunology; D002638:Chewing Gum / Q000009:adverse effects*; D005260:Female; D005520:Food Preservatives / Q000009:adverse effects*; D006801:Humans; D014581:Urticaria / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
chemical_list: D002638:Chewing Gum; D005520:Food Preservatives; D002084:Butylated Hydroxytoluene