Tumorigenic activity of non-alternant polynuclear aromatic hydrocarbons in newborn mice.
The tumorigenic activity of benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, and indeno-[1,2,3-cd]pyrene was evaluated in newborn CD-1 mice. The total doses of these non-alternant polycyclic aromatic hydrocarbons employed in this study ranged from 0.5 to 2.1 mumol per mouse. The results of this assay indicate that both benzo[b]fluoranthene and benzo[j]fluoranthene exhibit significant tumorigenic activity. In contrast to these results, neither benzo[k]fluoranthene nor indeno[1,2,3-cd]pyrene were tumorigenic under these assay conditions.
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D005260:Female; D005449:Fluorenes / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011721:Pyrenes / Q000633:toxicity*; D012995:Solubility
D002273:Carcinogens; D005449:Fluorenes; D011721:Pyrenes; C027704:benzo(j)fluoranthene; C006703:benzo(b)fluoranthene; C041508:indeno(1,2,3-cd)pyrene; C022921:benzo(k)fluoranthene