No heat shock protein synthesis is required for induced thermostabilization of translational machinery.
For Tetrahymena thermophila cells to survive at 43 degrees C, a normally lethal temperature, they require a pretreatment which either elicits the synthesis of heat shock proteins or one which brings about a change in the translational machinery of the cell such that is is not inactivated when transferred to 43 degrees C. In this report I present evidence showing that the latter modification can occur in the complete absence of protein synthesis, indicating that heat shock protein production is not required for the induced thermostabilization of the translational machinery.
D003513:Cycloheximide / Q000494:pharmacology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006358:Hot Temperature; D014176:Protein Biosynthesis; D013768:Tetrahymena / Q000502:physiology*; D013997:Time Factors
D006360:Heat-Shock Proteins; D003513:Cycloheximide