Effect of primidone in somatic and germ cells of mice.
Primidone, an anti-convulsant drug, was tested in mice for mutagenicity in somatic cells by the micronucleus test and in germ cells by the sperm-head abnormality assay. Mice were treated orally with the drug at doses of 4.37, 8.75 and 13.11 mg/mouse. The results indicate that the drug is capable of inducing mutations both in somatic and germ cells of mice.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D005854:Germ Cells / Q000187:drug effects*; D008297:Male; D051379:Mice; D009153:Mutagens; D010634:Phenobarbital / Q000378:metabolism; D011324:Primidone / Q000378:metabolism / Q000633:toxicity*; D013077:Sperm Head / Q000187:drug effects
D009153:Mutagens; D011324:Primidone; D010634:Phenobarbital