Isoelectric focusing of the human TSH receptor A subunit.
The water soluble A subunit of the human TSH receptor has been shown to have an isoelectric point of 5. As both TSH and TSH receptor antibodies have isoelectric points in the region of 8-10, charge-charge interactions must be of major importance in the binding of hormone or antibody to the TSH receptor A subunit.
D006801:Humans; D007525:Isoelectric Focusing; D046911:Macromolecular Substances; D011989:Receptors, Thyrotropin / Q000302:isolation & purification*; D013961:Thyroid Gland / Q000378:metabolism
D046911:Macromolecular Substances; D011989:Receptors, Thyrotropin