A prospective randomized study on neodymium-YAG laser irradiation versus TUR in the treatment of urinary bladder cancer.
122 patients with urinary bladder cancer of stage T-1 and T-2 were randomized for Neodymium-YAG laser irradiation (n = 62) or TUR (n = 60). Follow-up was carried out every 3 months for 2 years. Recurrence of tumor in treated area was seen in 3 patients (4.8%) in the laser group and in 19 patients (31.6%) in the TUR group. New tumors in non-treated areas occurred in 12 patients in the laser group and in 13 patients in the TUR group. It is to conclude that Neodymium-YAG laser irradiation is a safe and efficient treatment of bladder tumors of stage T-1 and superior to TUR except in very small tumors which can be completely removed in one piece without resecting into tumor tissue. In muscle invasive tumors of stage T-2, combined treatment with TUR and laser irradiation is superior to TUR alone. Occurrence of new tumors in non-treated areas is independent of treatment modality.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009366:Neoplasm Seeding; D011446:Prospective Studies; D011897:Random Allocation; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy* / Q000601:surgery