Glycosylated serum proteins and glycosylated haemoglobin in normal pregnancy.
Glycosylated haemoglobin (HbA1) and glycosylated serum protein concentrations (fructosamine) were monitored in 162 normal pregnancies. The response to the standard 75 g oral glucose tolerance test (OGTT) was used to exclude gestational diabetes. A significant increase in glucose intolerance, measured from the area under the OGTT-curve (r = 0.29, P less than 0.0005) and a highly significant decrease in serum albumin concentration (r = -0.79, P less than 0.0005) due to the redistribution of body water, as occurs during pregnancy, resulted in a statistically significant decrease in serum fructosamine concentration (r = -0.23, P less than 0.01) when related to gestational age in weeks.
D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D019270:Fructosamine; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006023:Glycoproteins; D006595:Hexosamines / Q000097:blood; D006801:Humans; D011247:Pregnancy / Q000097:blood*; D011254:Pregnancy in Diabetics / Q000097:blood / Q000175:diagnosis; D012016:Reference Values; D000093422:Glycated Serum Proteins
D001798:Blood Proteins; D019270:Fructosamine; D006442:Glycated Hemoglobin; D006023:Glycoproteins; D006595:Hexosamines; D000093422:Glycated Serum Proteins