The synergism of nucleoside antibiotics combined with guanine 7-N-oxide against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV).
Guanine 7-N-oxide was shown to have synergistic activity in combination with neplanocin A against a rhabdovirus, infectious hematopoietic necrosis virus (IHNV), as reported previously. We examined further the antiviral activity of guanine 7-N-oxide in combination with other nucleoside antibiotics against IHNV. Synergism was seen between guanine 7-N-oxide and D-eritadenine or cordycepin. It is considered that compounds inhibiting RNA methylation show synergism with guanine 7-N-oxide.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009705:Nucleosides / Q000494:pharmacology*; D012367:RNA, Viral / Q000096:biosynthesis; D012209:Rhabdoviridae / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D004338:Drug Combinations; D009705:Nucleosides; D012367:RNA, Viral; C046075:guanine 7-oxide; D006147:Guanine