Long-term effect of magnesium pyridoxal 5-phosphate glutamate in rabbits developing hypercholesterolemia.
36 male rabbits were fed with a diet enriched with 20 g cholesterol/kg for a period of 8 weeks under a strict daily dietary control. Magnesium pyridoxal 5-phosphate glutamate (MPPG, Sedalipid) was supplemented to the diet at different quantities. Hypercholesterolemia developed later and less pronounced in animals receiving a medium or high dose of MPPG. Microscopical analysis indicated a protective effect of MPPG on calcium deposition in the aorta. The fatty acid pattern in serum showed only minor differences and was unchanged in liver extracts in animals supplemented with MPPG. This observation suggest that MPPG may act on the mechanism of cholesterol absorption in the intestine.
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D005973:Glutamine / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000097:blood; D011732:Pyridoxal Phosphate / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D000924:Anticholesteremic Agents; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; D005973:Glutamine; D014527:Uric Acid; D011732:Pyridoxal Phosphate; C047672:magnesium-pyridoxal-5'-phosphate glutamate; D002784:Cholesterol