Differential co-expression of alpha-actin genes within the human heart.
Human cardiac muscle has been studied to determine whether the ratio of cardiac alpha-actin to skeletal alpha-actin varies between the different chambers of the human heart taken from a single individual. Using mRNA dot-blots, and DNA probes specific for the cardiac and skeletal alpha-actin isotypes, we have found that both cardiac and skeletal alpha-actin mRNAs are present and co-expressed throughout the human heart. The pattern of alpha-actin co-expression in the left and right ventricles and in the interventricular septum is approximately the same, with cardiac alpha-actin being the dominant isotype (approx. 80% of total). However, the left atrium has a different relative composition of the two actins, with an even higher level of cardiac alpha-actin expression (95% of total).
D000199:Actins / Q000032:analysis / Q000235:genetics*; D005786:Gene Expression Regulation; D006325:Heart Atria / Q000032:analysis; D006352:Heart Ventricles / Q000032:analysis; D006801:Humans; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000166:cytology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger
D000199:Actins; D012333:RNA, Messenger