Single-dose relative biological effectiveness and toxicity studies under conditions of hypothermia and hyperbaric oxygen.
An approach to using hyperbaric oxygen with radiation in a clinical situation has been described in the preceding paper in this issue. To ascertain whether there might be a change in the relative biological effectiveness of radiation on normal mammalian tissue treated under conditions of hypothermia and hyperbaric oxygen, the acute reaction to radiation of pig skin was studied. A single dose enhancement ratio at the erythema reaction level of 1.4 +/- 0.08 was obtained when compared with irradiation at normal body temperature in air. We studied also a series of antioxidant enzymes in rat liver and lung after exposure to hypothermia and hyperbaric oxygen. Enzyme changes were such as to combat oxygen toxicity which might develop as a result of the pre-treatment.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006931:Hyperbaric Oxygenation; D007036:Hypothermia, Induced; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008297:Male; D010100:Oxygen / Q000633:toxicity; D051381:Rats; D012062:Relative Biological Effectiveness; D012867:Skin / Q000528:radiation effects*; D013552:Swine
D010100:Oxygen