Antibodies to dietary antigens in coeliac disease.
Antibodies to gliadin (AGA) were found in 77 (94%) of 82 sera from patients with active coeliac disease (untreated and after gluten challenge). Although IgG AGA had a higher nosological sensitivity than IgA AGA (88% versus 67%), their nosological specificity was lower than that of IgA antibodies (87% versus 100%). The sensitivity of antibodies to casein, beta-lactoglobulin, and ovalbumin in active coeliac disease varied from 36% to 48% without significant difference between IgG and IgA antibodies. IgG and IgA antibodies to milk and egg proteins showed a specificity similar to that of AGA, although some IgA antibodies other than AGA were found in disease controls (Crohn's disease, ulcerative colitis, post-enteritis syndrome).
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000941:Antigens; D002364:Caseins / Q000276:immunology; D002446:Celiac Disease / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004044:Dietary Proteins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007782:Lactoglobulins / Q000276:immunology; D008875:Middle Aged; D010047:Ovalbumin / Q000276:immunology; D010940:Plant Proteins / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D002364:Caseins; D004044:Dietary Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007782:Lactoglobulins; D010940:Plant Proteins; D010047:Ovalbumin; D005903:Gliadin