Atropine in the treatment of baclofen overdose.
A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
D000293:Adolescent; D001285:Atropine / Q000627:therapeutic use*; D001418:Baclofen / Q000506:poisoning*; D001919:Bradycardia / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male
D001285:Atropine; D001418:Baclofen