title: Effect of compression on fracture healing. Plate fixation studied in rabbits.
abstract: Bilateral osteotomies in rabbit tibiae were secured with six-hole rigid plates, using axial compression on the right and no compression on the left side. Histological, histomorphometric and torsiometric analysis was performed up to 24 weeks postoperatively. Histological analysis showed end-to-end primary bone healing regardless of treatment. The fracture gaps tended to be smaller in the compression osteotomies, but union was achieved within the same time on both sides, and at 6 weeks torsiometric analysis of the paired specimens revealed similar mechanical properties. By the time the fracture had united both groups of bones showed similar degrees of subendosteal resorption. As a result of this porotic transformation the strength of the cortical bone was slightly impaired from 6 weeks onward, whether or not compression had been applied. The results suggest that axial compression does not augment fracture healing of plated cortical bone.
mesh_terms: D000818:Animals; D001860:Bone Plates; D001862:Bone Resorption; D001863:Bone Screws; D005593:Fracture Fixation, Internal / Q000379:methods*; D008852:Microradiography; D010027:Osteotomy; D011817:Rabbits; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology; D013978:Tibial Fractures / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D014945:Wound Healing