[Condition of the endothelium of the aorta during hypodynamia].
The state of the aortic internal lining under conditions of hypodynamia has been studied on 47 white male rats morphometrically and stereologically in film preparations of endothelium. The results of measurements have been treated by means of the moving average method. Significance of differences has been estimated using nonparametric criterion of Wilcoxon--Mann--Whitney. For objective periodization of reactions centring of approximated curves with successive calculation of the variation coefficient of the centered ordinates in every time point has been calculated. Hypokinesia produces manifested changes of phasic character in endothelium. Restoration of the disturbed homeostasis in endothelium is ensured on the bases of both intracellular and cellular regeneration. At late stages (beginning from the 20th day) density in arrangement of endotheliocytes in the layer decreases, as well as the degree of tissue regularity. Polymorphism of endothelium is essentially manifested. Parameters demonstrating destruction and death of cells are rather high. Under such conditions, the response reaction of the arterial wall could acquire the character of developing atherosclerotic lesion.
D000222:Adaptation, Physiological; D000818:Animals; D001011:Aorta / Q000033:anatomy & histology*; D001018:Aortic Diseases / Q000209:etiology; D001161:Arteriosclerosis / Q000209:etiology; D003594:Cytoplasmic Granules; D004727:Endothelium / Q000473:pathology; D008297:Male; D008938:Mitosis; D009068:Movement; D051381:Rats; D013997:Time Factors; D014617:Vacuoles
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