The effect of furazolidone on some clinical and biochemical parameters in goats.
Furazolidone (FZ) administered to goats orally at the recommended therapeutic dose (10 mg/kg body weight for 5 days) resulted in significant decreases in heart rate, pulse rate, and rectal temperature. No change was observed in respiratory rate or body weight, although a tendency towards a decrease in the latter was observed. An increase in the number of the erythrocytes was found. FZ also produced significant decreases in the pseudocholinesterase activity and plasma concentrations of total protein and ascorbic acid. A significant increase in the adrenal cholesterol concentration was observed while the weight of adrenal glands and their ascorbic acid concentration and content were unaffected. No significant histopathological changes were observed in treated goats.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000032:analysis; D004906:Erythrocyte Count / Q000187:drug effects / Q000662:veterinary; D005664:Furazolidone / Q000494:pharmacology*; D006041:Goats / Q000097:blood / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D005664:Furazolidone; D002784:Cholesterol