title: Influence of probucol ((4,4'-isopropylidine dithio)-bis(2,6-di-t-butyl-phenol)) on egg yolk cholesterol content and performance of laying hens.
abstract: Addition of the hypocholesteremic agent Probucol ((4,4'-isopropylidine dithio)-bis(2,6-di-t-butyl-phenol)) to the diet of laying hens at up to 1% significantly reduced egg yolk cholesterol content (mg/g yolk) without impairment of rate of egg production, egg weight, shell strength, albumen quality, or other production related parameters. Dietary concentration of .1% Probucol significantly reduced yolk cholesterol within 2 weeks after feeding. Higher concentrations did not further reduce yolk cholesterol. Probucol at .025% reduced egg yolk cholesterol within 4 weeks after feeding, but after 8 weeks of feeding, eggs from hens fed .025% Probucol did not differ significantly in yolk cholesterol from those fed the basal unsupplemented diet. This suggests possible adaptation in cholesterol synthesis by the laying hen.
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D002784:Cholesterol / Q000032:analysis*; D004530:Egg Yolk / Q000032:analysis*; D005260:Female; D010058:Oviposition / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D011341:Probucol / Q000494:pharmacology*
chemical_list: D010636:Phenols; D002784:Cholesterol; D011341:Probucol