Investigation of bilirubin removal by NK-110 resin hemoperfusion in jaundiced dogs.
A jaundiced dog model was made by common bile duct-inferior vena cava shunt with a silicon rubber tube. Blood bilirubin levels increased from 0.25 +/- 0.16 (SD) mg% to 15 +/- 1.4 (SD) mg%. These dog models were treated with a column containing 200 gm of macroreticular resin NK-110 which was linked between the femoral artery and vein. The rate of blood flow through the column was 200 ml/min. It was shown that total bilirubin reduced from 15 +/- 1.4 (SD) to 7.4 +/- 0.61 (SD), conjugated bilirubin decreased from 6.97 +/- 0.63 to 3.5 +/- 0.33 (SD) and unconjugated bilirubin from 7.8 +/- 2.1 to 4.2 +/- 0.4 (SD). There were no significant changes in protein, electrolyte, blood gases and acid base balance. Results show that NK-110 resin has good blood-compatible and adsorption properties.
D000327:Adsorption; D000818:Animals; D001663:Bilirubin / Q000378:metabolism*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006464:Hemoperfusion; D007475:Ion Exchange Resins; D007565:Jaundice / Q000628:therapy*; D008297:Male; D011137:Polystyrenes; D012117:Resins, Synthetic
D007475:Ion Exchange Resins; D011137:Polystyrenes; D012117:Resins, Synthetic; C051007:NK 110 resin; D001663:Bilirubin