Enhancement of ketoconazole penetration across the blood-brain barrier of mice by dimethyl sulfoxide.
Mice were treated with ketoconazole with and without dimethyl sulfoxide. Concentrations of ketoconazole at 3 and 5 h after treatment were significantly higher in serum (P less than 0.05) and brain tissue homogenate (P less than 0.01) of mice treated with dimethyl sulfoxide than in those of mice not treated with dimethyl sulfoxide.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D007654:Ketoconazole / Q000378:metabolism*; D007700:Kinetics; D051379:Mice
D007654:Ketoconazole; D004121:Dimethyl Sulfoxide