Amniotic fluid embolism and leukotrienes.
Extracts of experimental amniotic fluid embolism from rabbit lungs showed the same biologic activities as leukotrienes and a peak on high-performance liquid chromatography at the same retention time as leukotriene D4. Acute death was prevented by administration of 5-lipoxygenase inhibitor. These results suggest the possibility that leukotrienes contribute to the clinical and pathophysiologic features of amniotic fluid embolism.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000494:pharmacology; D004619:Embolism, Amniotic Fluid / Q000209:etiology*; D005260:Female; D008168:Lung / Q000032:analysis*; D011247:Pregnancy; D011817:Rabbits; D013189:SRS-A / Q000032:analysis* / Q000037:antagonists & inhibitors
D002867:Chromones; D013189:SRS-A; C006312:FPL 55712