title: Hepatitis B serological patterns of asymptomatic carriers in an endemic region and evaluation of blood plasma as a source of hepatitis B vaccine.
abstract: Hepatitis B serological studies were carried out in 251 asymptomatic carriers of HBsAg living in an endemic rural area of Cachoeiro do Itapemirim (545 km distant from Rio de Janeiro) in order to evaluate this population as a potential source of blood plasma for hepatitis B vaccine production. A pilot study on HBsAg purification from plasma was also performed to estimate antigen yield.
mesh_terms: D000293:Adolescent; D000328:Adult; D002353:Carrier State / Q000097:blood / Q000276:immunology*; D002648:Child; D006509:Hepatitis B / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D010949:Plasma / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000302:isolation & purification*
chemical_list: D006514:Hepatitis B Surface Antigens; D014761:Viral Hepatitis Vaccines