[Prophylactic effects of sodium oxybutyrate and lithium oxybutyrate on stress-induced depression of the activity of normal killers in mice].
The possible use of sodium hydroxybutyrate and lithium hydroxybutyrate for the prevention of the decrease in splenic natural killer activity has been studied in CBA mice upon 6-hour immobilization stress. Both agents proved to be effective in preventing stress-induced depression of NK activity. However, a protective effect of lithium hydroxybutyrate was observed at a dose 4 times lower than that of sodium hydroxybutyrate.
D000818:Animals; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008094:Lithium / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009942:Organometallic Compounds; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000276:immunology*
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D012978:Sodium Oxybate; D008094:Lithium
Profilakticheskie éffekty oksibutirata natriia i oksibutirata litiia pri stressornoĭ depressii aktivnosti normal'nykh killerov u mysheĭ.