[Glucose utilization and activity of glucose-6-phosphate dehydrogenase, isocitrate dehydrogenase and malate dehydrogenase in rat erythrocytes after treatment with tuberculostatic agents].
Metazamide, phthivazid, larusan and rifamycin were shown to inhibit activities of glucose-6-phosphate-, isocitrate- and malate dehydrogenases in male rats within 10-14 days by 14-32%; as a result of this, the rate of glucose consumption was decreased in blood, as shown by the shape of sugar plots after loading with 300 mg of glucose. Administration of these drugs led to elevation of sugar curves by 11-18% as compared with controls. p-Amino-salicylic acid, isoniazid and protionamide inhibited the enzymatic activity but affected the rate of glucose consumption only slightly. Ethambutal activated these enzymes by 13-29%; the highest rate of glucose consumption was observed in presence of the drug.
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors / Q000097:blood*; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors / Q000097:blood*; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D051381:Rats
D000995:Antitubercular Agents; D001786:Blood Glucose; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Utilizatsiia gliukozy i aktivnost' gliukozo-6-fosfatdegidrogenazy, izotsitratdegidrogenazy i malatdegidrogenazy éritrotsitov krys pri deĭstvii tuberkulostaticheskimi preparatami.