title: Effects of micellar oleic acid on canine jejunal blood flow and neurotensin release.
abstract: The purpose of this study was to evaluate the role of neurotensin in the local regulation of the lipid-induced jejunal hyperemia. Total blood flow and the arteriovenous hormone concentration difference were measured in isolated jejunal loops of anesthetized dogs with either saline, bile (10% in normal saline), oleic acid (40 mM in normal saline), or oleic acid and bile in the lumen. The bile-oleic acid mixture produced a sustained increase (+25 +/- 3%) in jejunal blood flow, whereas neurotensin release reached a maximum (1.14 +/- 0.34 pmol X min-1 X 100 g-1) 2 min after initiation of the response and then returned to control. Venous neurotensin concentrations also reached a maximum (51 +/- 17 pmol/l) at 2 min. There were no significant changes in either blood flow or neurotensin release in response to the other test solutions. Intra-arterial infusion of neurotensin did not significantly decrease jejunal vascular resistance (-12 +/- 3%) until venous concentrations of 478 +/- 101 pmol/l were attained. It seems unlikely, then, that neurotensin plays any role in the regulation of the lipid-induced jejunal hyperemia.
mesh_terms: D000818:Animals; D001158:Arteries; D001646:Bile / Q000502:physiology; D001783:Blood Flow Velocity / Q000187:drug effects; D003102:Colloids; D004285:Dogs; D005260:Female; D007583:Jejunum / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008823:Micelles; D009496:Neurotensin / Q000097:blood / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D014655:Vascular Resistance; D014680:Veins
chemical_list: D003102:Colloids; D008823:Micelles; D009829:Oleic Acids; D019301:Oleic Acid; D009496:Neurotensin