The role of caudate nucleus in dermorphin-induced catalepsy in rats.
Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin. These results suggest that caudate nucleus plays an inhibitory role in controlling the cataleptic response and its integrity is essential for full development of dermorphin-induced rigidity.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D009127:Muscle Rigidity / Q000139:chemically induced; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D010146:Pain / Q000503:physiopathology; D051381:Rats
D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin