An experimental model to study blood and inflammatory neutrophils.
We sought to develop an experimental animal model in order to study the effects of hypothermia on host defences under conditions which were similar to those used for humans. We required a large animal which could tolerate arterial and venous catheters and serial blood sampling without significantly altering its blood volume and blood pressure. The animal should be intubated and ventilated to control blood gases and fluid and electrolyte balance. Finally the model should have anatomic, metabolic and physiologic similarities to humans. We describe an experimental pig model which appears to fulfill these criteria and provide important information relevant to man.
D000818:Animals; D001784:Blood Gas Analysis; D002465:Cell Movement / Q000187:drug effects; D004195:Disease Models, Animal / Q000097:blood; D004837:Epinephrine / Q000494:pharmacology; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D007958:Leukocyte Count; D009504:Neutrophils / Q000166:cytology; D010998:Pleurisy / Q000139:chemically induced; D012107:Research Design; D013552:Swine
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone; D004837:Epinephrine