title: Severe metabolic alkalosis complicating regional citrate hemodialysis.
abstract: Regional citrate hemodialysis has been effectively used as an alternative to heparin anticoagulation during dialysis of patients at increased risk for bleeding. Few complications have been noted; however, we report the occurrence of severe metabolic alkalosis in two patients requiring high infusion rates of citrate during hemodialysis while being mechanically ventilated. Careful monitoring of acid-base status is mandatory in this setting, and reduction of citrate dose may be advisable.
mesh_terms: D000368:Aged; D000471:Alkalosis / Q000209:etiology*; D002951:Citrates / Q000009:adverse effects*; D019343:Citric Acid; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000378:metabolism / Q000628:therapy
chemical_list: D002951:Citrates; D019343:Citric Acid