title: Is there a lithium withdrawal syndrome?
abstract: Patients who discontinued lithium after a mean of 29 +/- 21 months prophylaxis were compared with a similar group who were not taking the drug; all had only been in hospital once, and satisfied DSM-III criteria for mania. During the first three months following withdrawal of lithium, significantly more patients relapsed than in the control group; after this period, the rate was identical. These findings suggest that lithium withdrawal exists as a clinical phenomenon and that a period of lithium treatment does not improve the long-term prognosis, once the drug has been stopped.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000517:prevention & control*; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects*; D012008:Recurrence; D012189:Retrospective Studies; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology*; D013997:Time Factors
chemical_list: D008094:Lithium