title: Vitamin C partially reversed some biochemical changes produced by vitamin E deficiency.
abstract: Feeding a basal diet free of vitamins E and C to weanling male rats for 8 months resulted in biochemical changes characteristic of vitamin E deficiency. These included increased liver thiobarbituric acid values; decreased blood GSH levels, plasma vitamin E levels, and glutathione peroxidase activities; and increased activities of plasma pyruvate kinase, glutamic-oxaloacetic transaminase, creatine kinase, lactic dehydrogenase, and malic dehydrogenase. Tube-feeding vitamin C for 21 days resulted in partial reversal effects on the above parameters except activities of glutathione peroxidase, lactic dehydrogenase, and malic dehydrogenase. The results suggest that vitamin C may spare in part the metabolism of vitamin E through its antioxidant property.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D004032:Diet; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008291:Malate Dehydrogenase / Q000097:blood; D008297:Male; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000097:blood; D014811:Vitamin E Deficiency / Q000201:enzymology / Q000378:metabolism*
chemical_list: D014810:Vitamin E; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D011770:Pyruvate Kinase; D003402:Creatine Kinase; D005978:Glutathione; D001205:Ascorbic Acid