Effects of food and gender on the pharmacokinetics of methotrexate in children.
The effects of food and gender on the oral absorption of methotrexate (MTX) in 16 Jordanian children were investigated. Plasma levels of MTX were measured by a fluorescence polarization immunoassay. The extent of absorption and the rate of elimination of the drug were determined in both males and females, before and after meals and data were statistically analyzed using two-way analysis of variance. The results showed great variability in individual MTX Cmax, t1/2, Kel. and AUC. Although no statistically significant differences were found in the pharmacokinetic parameters of the drug among the groups, apparent differences were observed in the mean values of these parameters.
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005502:Food; D006801:Humans; D007700:Kinetics; D008297:Male; D008727:Methotrexate / Q000097:blood / Q000378:metabolism*; D012737:Sex Factors
D008727:Methotrexate