title: Refractory depression treated with high doses of monoamine oxidase inhibitor.
abstract: Two treatment-refractory cases of depression were treated with doses of monoamine oxidase inhibitors (MAOIs) that exceeded the recommended therapeutic range. Both patients improved without any side effects. It appears that high doses of MAOIs when used with caution in responsible patients may be another method for treating refractory depression.
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010624:Phenelzine / Q000008:administration & dosage / Q000009:adverse effects; D014191:Tranylcypromine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D010624:Phenelzine