title: Acute effects of pirenzepin on bronchospasm.
abstract: The response to pirenzepin, a new acetylcholine receptor blocking agent, was assessed and compared to placebo in patients with reversible bronchoconstriction. A single intravenous injection of 20 mg of pirenzepin induced a significant reduction of airway resistance compared to placebo (p less than 0.05). The anticholinergic substance pirenzepin appears to be useful in the treatment of bronchospasm.
mesh_terms: D000368:Aged; D000403:Airway Resistance / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010890:Pirenzepine / Q000627:therapeutic use*
chemical_list: D010890:Pirenzepine