The influence of indomethacin on tendon healing. A biomechanical and biochemical study.
The influence of indomethacin on the biomechanical and biochemical properties of tendons during their healing was investigated. In 68 New Zealand White rabbits a transverse tenotomy followed by repair with a criss-cross suture was performed in the plantaris longus tendon of the left hind limb. The leg was immobilized for 4 weeks postoperatively in a long-leg plastic splint. Half of the animals were treated with indomethacin, 10 mg/kg/day orally, and the other half with placebo. After 4, 8, and 16 weeks of treatment the animals were killed and biomechanical and biochemical parameters were measured. After 16 weeks there was a significant increase in tensile strength in the indomethacin group. There were only small biochemical differences between the groups. However, there was a slight but significant decrease in the amount of soluble collagen in the indomethacin group. This may indicate a higher degree of cross-linkage following indomethacin treatment, which might explain the increased tensile strength.
D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D011817:Rabbits; D013708:Tendon Injuries / Q000188:drug therapy; D013710:Tendons / Q000187:drug effects* / Q000378:metabolism; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D003094:Collagen; D007213:Indomethacin