Naloxone, naltrexone and body temperature.
The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltrexone produce an equivalent hypothermia but this hypothermia was just as pronounced during the dark as in the light part of the cycle.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009270:Naloxone; D009271:Naltrexone