Hemangioblastoma of the cerebellum--an immunocytochemical study.
Immunocytochemical studies using a new antibody against endothelial cells and commercially available antibodies against glial fibrillary acidic protein (GFAP) and S-100 protein were performed on 10 cerebellar hemangioblastomas in order to clarify the controversy over the origin of stromal cells. Neither cytoplasmic immunoreactivity for endothelial cell markers nor for anti-GFAP and anti-S-100 protein was found in these cells. Endothelial cell markers reacted positively only with neoplastic capillaries of the tumors and anti-GFAP and anti-S-100 protein were only found in glial remainders in the centers and margins of the tumors.
D000906:Antibodies / Q000032:analysis*; D002528:Cerebellar Neoplasms / Q000276:immunology* / Q000473:pathology; D004727:Endothelium / Q000276:immunology / Q000648:ultrastructure; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology*; D006394:Hemangiosarcoma / Q000276:immunology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D009418:S100 Proteins / Q000276:immunology*
D000906:Antibodies; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins