title: Sample size requirements and the cost of a randomized clinical trial with repeated measurements.
abstract: This paper discusses the advantage of using repeated outcome measurements on subjects in a clinical trial. We choose the number of subjects and the number of repeated outcome measurements to minimize a given cost function so that the clinical trial has power (1-beta) for specified significance level alpha. An example illustrates the results and emphasizes the importance of study design and of critical evaluation of how one measures the study endpoint.
mesh_terms: D001699:Biometry; D002986:Clinical Trials as Topic / Q000191:economics / Q000379:methods*; D003365:Costs and Cost Analysis; D006801:Humans; D008962:Models, Theoretical; D011897:Random Allocation