Influence of thromboxane A2 inhibition on the development of hydronephrotic atrophy.
The development of hydronephrotic atrophy as measured by dry and wet weight in relation to wholebody weight, in rats after complete unilateral ureteral obstruction could be influenced by oral administration of OKY 1581, an inhibitor of thromboxane A2 synthesis. The data are consistent with the thesis that preglomerular thromboxane A2-mediated active vasoconstriction is involved, most likely by ischemia, in the development of hydronephrotic atrophy, at least in the renal cortex.
D000818:Animals; D001284:Atrophy / Q000209:etiology; D005260:Female; D006869:Hydronephrosis / Q000473:pathology / Q000503:physiopathology*; D007672:Kidney Cortex / Q000473:pathology; D007679:Kidney Medulla / Q000473:pathology; D008689:Methacrylates / Q000494:pharmacology; D051381:Rats; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*; D014517:Ureteral Obstruction / Q000473:pathology / Q000503:physiopathology
D008689:Methacrylates; D013928:Thromboxane A2; C031517:2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid