[Electroencephalographic analysis of the central action of halonal].
The experiments on rabbits revealed the depressant effect of anticonvulsant drug halonal on spontaneous bioelectrical activity and electroexcitability of the motor area of the cerebral cortex, caudate nucleus, intralaminar nuclei of the thalamus and midbrain reticular formation. The drug exerts no effect on the amygdala and hippocamp. The mechanism of the anticonvulsant effect of halonal involves inhibition of the caudo-thalamo-cortical synchronizing system that presumably disorders the occurrence of the hypersynchronous charge in the cortical neurons and prevents the development of a convulsive fit.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D008297:Male; D011817:Rabbits; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control
D000927:Anticonvulsants; D001463:Barbiturates; C002915:benzobarbital
Elektroéntsefalograficheskiĭ analiz tsentral'nogo deĭstviia galonala.