Glomerular permeability in the isolated perfused rat kidney.
Increased glomerular permeability to protein occurs during isolated rat kidney perfusion in the absence of ultrastructural changes in the glomerular capillary wall. The increase is greater with age, varies with strain and is reduced by amino acid supplementation of the perfusate. Glomerular permeability to protein is thus perceptibly influenced by non-pathogenic stimuli. Such phenomena, in turn, may influence glomerular function in disease or after experimental damage.
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D007678:Kidney Glomerulus / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D008297:Male; D010477:Perfusion; D010539:Permeability; D011506:Proteins / Q000378:metabolism; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D011506:Proteins