Reinnervation of experimental superficial wounds in rats.
Sensory reinnervation of a superficial skin wound in the rat was studied by labeling sensory axons with anterogradely transported wheat germ agglutinin-horseradish peroxidase. Reinnervation starts after 3 days from the edge of the wound as well as from beneath the wound. About 2 weeks after the production of the wound, some hyperinnervation appears to be present, but after a few additional weeks, the innervation pattern is essentially normal. The results indicate that structural recovery of sensory axons is rapid and probably complete when skin wounds heal with no or minimal scar formation.
D000818:Animals; D005260:Female; D006735:Horseradish Peroxidase; D051381:Rats; D011919:Rats, Inbred Strains; D011984:Sensory Receptor Cells / Q000033:anatomy & histology* / Q000502:physiology; D012867:Skin / Q000294:innervation*; D012879:Skin Physiological Phenomena; D014909:Wheat Germ Agglutinins; D014945:Wound Healing
D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase