Inhibition of muscle tropomyosin polymerization by DNAse I.
Tropomyosin polymerization is inhibited by DNAse I, an endonuclease which also interacts with G-actin. A 1:4 molar ratio of DNAse I to adult chicken pectoralis muscle tropomyosin almost completely prevents the increased viscosity of tropomyosin under polymerizing ionic conditions. While G-actin binding to DNAse I inhibits the DNAse I hydrolysis of DNA, tropomyosin does not affect this enzymatic activity. G-actin-DNAse I interaction is also not altered by tropomyosin.
D000199:Actins / Q000037:antagonists & inhibitors; D000818:Animals; D001665:Binding Sites; D002645:Chickens; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors; D003850:Deoxyribonuclease I / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D011108:Polymers; D011485:Protein Binding / Q000187:drug effects; D014335:Tropomyosin / Q000037:antagonists & inhibitors*; D014783:Viscosity
D000199:Actins; D003598:Cytoskeletal Proteins; D011108:Polymers; D014335:Tropomyosin; D003850:Deoxyribonuclease I