Hypouricemia due to increased tubular urate secretion.
A 45-year-old woman had hypouricemia (serum uric acid, 1.0-2.3 mg/dl) with increased uric acid clearance (29.8 +/- 9.3 ml/min/1.73 m2). Uric acid clearance to creatinine clearance ratio (Cua/Ccr) was suppressed markedly by pyrazinamide to 2.3% and surprisingly enhanced by probenecid to 227.8%. No other renal tubular or metabolic abnormalities were detected. This previously unreported high postprobenecid Cua/Ccr suggests that markedly increased urate secretion by the renal tubule is responsible for hypouricemia in this patient.
D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D008875:Middle Aged; D011339:Probenecid; D011718:Pyrazinamide; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D014527:Uric Acid; D011718:Pyrazinamide; D003404:Creatinine; D011339:Probenecid