title: Single cell translocations in couples with multiple spontaneous abortions.
abstract: Single cell translocations have been previously reported to occur in normal lymphocyte cultures. Comparison of the frequency of these in 140 individuals referred for a history of multiple miscarriages and 415 individuals referred for a history of multiple miscarriages and 415 individuals referred for other reasons showed a significantly greater number of single cell translocations in the former group. This group also had a significantly greater number of other types of single cell structural abnormalities. Increased chromosome instability, chromosome mosaicism, residual fetal trophoblasts, and immunological differences are discussed in considering the possible etiology.
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D011247:Pregnancy; D014178:Translocation, Genetic