An abnormal retinal projection to the lateral posterior nucleus in micrencephalic rats.
The retinofugal projections of albino rats made micrencephalic by prenatal exposure to the cytotoxic teratogen methylazoxymethanol acetate (MAM Ac) have been examined. The only abnormality noted was an increased projection to the lateral posterior nucleus of the thalamus in rats exposed to MAM Ac on embryonic day 15. The relatively normal retinofugal projections were surprising in view of the extensive damage induced by prenatal exposure to this drug.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D005260:Female; D005829:Geniculate Bodies / Q000002:abnormalities; D008746:Methylazoxymethanol Acetate / Q000031:analogs & derivatives; D008831:Microcephaly / Q000139:chemically induced / Q000473:pathology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000002:abnormalities*; D013477:Superior Colliculi / Q000002:abnormalities; D013787:Thalamic Nuclei / Q000002:abnormalities*; D014795:Visual Pathways / Q000002:abnormalities*
D008746:Methylazoxymethanol Acetate; C030667:methylazoxymethanol