Bone oxalate in a long-term hemodialysis patient who ingested high doses of vitamin C.
We performed a bone biopsy on a patient who had been receiving hemodialysis for 23 years. The bone had oxalate deposition. Previous bone biopsies had shown osteitis fibrosis without oxalate deposition. The osteoid area was increased (11% of bone area), as was the fibrosis (6.1% of tissue area) and aluminum deposition (38% of surface). Bone formation rate was normal (259 mu 2/mm2/d). We examined bone biopsies of 22 patients who had been receiving hemodialysis for over 10 years, and none had oxalate deposits. We discovered that our patient had been ingesting 2.6 g/d of vitamin C. The bone oxalate deposition may have been caused by the ingestion of high doses of vitamin C.
D001205:Ascorbic Acid / Q000008:administration & dosage*; D001706:Biopsy; D001842:Bone and Bones / Q000032:analysis*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000032:analysis*; D006435:Renal Dialysis; D012651:Self Medication; D013997:Time Factors
D010070:Oxalates; D001205:Ascorbic Acid