[Antitumor activity of doxorubicin in respect to solid tumors in mice].
Antitumor activity of doxorubicin, an antibiotic prepared in the USSR was studied with respect to 4 solid tumors of mice: lymphosarcoma LIO-1, sarcoma 180, pregastric cancer OZh5 and melanoma B-16. Doxorubicin showed high antitumor activity against lymphosarcoma and sarcoma 180. However, it was somewhat lower than that of rubomycin and carminomycin. By selective antitumor activity against mouse pregastric cancer doxorubicin was superior to rubomycin and carminomycin. Estimation of antitumor activity of doxorubicin revealed its advantages in inhibition of melanoma B-16 growth, while carminomycin was superior in prolonging the animal life-span.
D000818:Animals; D002360:Carubicin / Q000627:therapeutic use / Q000633:toxicity; D003630:Daunorubicin / Q000627:therapeutic use / Q000633:toxicity; D004317:Doxorubicin / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*
D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
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