title: Isoelectric focusing studies of transferrin and haptoglobin subtypes in an Australian white population.
abstract: This investigation presents the results of Hp and Tf subtyping of sera from 307 Australian whites by means of isoelectric focusing. Five Hp alleles were detected, these being Hp1F = 0.168, Hp1S = 0.235, Hp2FF = 0.003, Hp2FS = 0.561 and Hp2SS = 0.033. In the Tf system six alleles were found, TfC1 = 0.761, TfC2 = 0.176, TfC3 = 0.054, TfC6 = 0.002, TfB = 0.006 and TfD = 0.002. The usefulness of IEF together with modifications was highlighted for differentiating Tf and Hp subtypes; in particular, the absence of Hp2FF and Hp2SS in some earlier studies could be related to the technique used. The implication of the simultaneous presence of B and D transferrin variants in Caucasian populations is discussed.
mesh_terms: D000483:Alleles; D001315:Australia; D005787:Gene Frequency; D006242:Haptoglobins / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007525:Isoelectric Focusing; D014168:Transferrin / Q000235:genetics* / Q000302:isolation & purification; D044465:White People
chemical_list: D006242:Haptoglobins; D014168:Transferrin