title: Effects of dietary lipids on frequency and force in atrial muscle at 10 MPa.
abstract: Spontaneously beating atrial preparations, from rats fed different lipid diets, were compressed to 10 MPa. The following observations were made: Different lipid diets altered the ratio of omega-6/omega-3 polyunsaturated fatty acids of the cardiac phospholipids. Beating frequency and twitch tension at surface pressure was unaffected by the diets. Compression to 10 MPa caused a decrease in spontaneous beating frequency and an increased twitch tension in all preparations. The decrease in beating frequency was inversely related to the omega-6/omega-3 ratio. Pressure induced increase in twitch tension was not affected by the diets. N2O dissolved in the tissue bath solution partly counteracted the pressure-induced changes.
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006325:Heart Atria; D006339:Heart Rate; D006874:Hydrostatic Pressure; D007537:Isometric Contraction / Q000187:drug effects; D008563:Membrane Lipids / Q000032:analysis; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration
chemical_list: D004041:Dietary Fats; D008563:Membrane Lipids; D010743:Phospholipids