Rubella vaccination: a study in adult male volunteers.
One hundred adult male volunteers were randomized to receive either Merieux or Wellcome RA27/3 rubella vaccine. Prior to vaccination, 10% of the subjects were seronegative and all of these seroconverted. No significant boosting effect was found in those with a high pre-vaccine titre but some boost was shown in those with a low level. Side-effects reported were mild and self-limiting. No clinically or statistically significant difference could be found between the two vaccines. It is suggested that in view of the finding of 10% seronegative adult males it would be worthwhile considering routine screening of all medical staff who have contact with women in the early months of pregnancy.
D000328:Adult; D000917:Antibody Formation; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D011897:Random Allocation; D012410:Rubella Syndrome, Congenital / Q000517:prevention & control; D012411:Rubella Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D012698:Serologic Tests; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D012411:Rubella Vaccine; D014613:Vaccines, Attenuated