[Antithrombin III inhibition of the reaction to thrombin excitation of the anticoagulation system].
It has been established that intravenous administration of alpha-thrombin-antithrombin III preparations (1 mkM) has practically no effect on anticoagulation parameters (thrombin time, additive fibrinolytic activity, nonenzymatic fibrinolysis and nonenzymatic fibrinolytic activity). Administration of 1 mkM of alpha-thrombin caused a statistically significant increase of all the parameters. The experiments on perfusion of the humorally isolated sinocarotid area of the rabbit with alpha-thrombin-antithrombin III preparations (1.25 mkM) showed no changes peculiar to the induction of anticoagulation response with thrombin. It is concluded that antithrombin III blocks the ability of thrombin to activate anticoagulation system function.
D000818:Animals; D000990:Antithrombin III / Q000302:isolation & purification / Q000494:pharmacology*; D002346:Carotid Sinus / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects*; D008297:Male; D010477:Perfusion / Q000379:methods; D011817:Rabbits; D051381:Rats; D013917:Thrombin / Q000302:isolation & purification / Q000494:pharmacology*; D013918:Thrombin Time; D013997:Time Factors
D000990:Antithrombin III; D013917:Thrombin
Ingibirovanie antitrombinom III reaktsii vozbuzhdeniia trombinom protivosvertyvaiushcheĭ sistemy.