Effects of alpha-momorcharin, beta-momorcharin and alpha-trichosanthin on lipogenesis and testicular and adrenal steroidogenesis in vitro and plasma-glucose levels in vivo.
The effects of alpha-momorcharin, beta-momorcharin and alpha-trichosanthin on lipogenesis in isolated rat adipocytes were examined. None of the three abortifacient proteins possessed lipogenic activity. The plant proteins did not affect the plasma-glucose level in fasting mice nor did they affect luteinizing hormone-induced testosterone production in isolated rat Leydig cells or corticotropin-induced corticosterone production in isolated rat adrenal decapsular cells by the end of a 2-h incubation period. The results suggest that the functions of adipocytes, adrenal decapsular cells, Leydig cells and pancreatic beta cells were not greatly affected after short-term exposure to the abortifacient proteins.
D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology; D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007985:Leydig Cells / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010940:Plant Proteins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012269:Ribosomal Proteins; D054788:Ribosome Inactivating Proteins; D013256:Steroids / Q000096:biosynthesis*; D013737:Testis / Q000378:metabolism*; D015978:Trichosanthin
D000020:Abortifacient Agents, Nonsteroidal; D001786:Blood Glucose; D008055:Lipids; D010940:Plant Proteins; D012269:Ribosomal Proteins; D013256:Steroids; D015978:Trichosanthin; C039582:MMC protein, Momordica charantia; D054788:Ribosome Inactivating Proteins