Effects of antiglaucoma drugs on the blood flow in rabbit eyes.
Although it is essential that intraocular pressure (IOP) be reduced in glaucoma treatment, it is also vitally important to provide sufficient blood flow to eye tissues so that healthy visual field is maintained. It is possible for an agent to reduce IOP and blood supply to the eye. In that case, glaucoma appears to be under control since IOP has been reduced to within normal range, yet the disease is actually progressing, causing damage to the retina, optic nerve, and other tissues. The 85Sr-microsphere technique was used to study the effects of several antiglaucoma drugs on blood supply to various eye tissues. It was found that pilocarpine, L-timolol, D-timolol and haloperidol are good drugs to use in treating glaucoma because they do not reduce ocular blood flow. D-timolol is particularly good because it does not cause side effects through beta-adrenergic blockade or cholinergic stimulation. On the other hand, trifluperidol and moperone reduce IOP effectively, but also decrease blood supply.
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002090:Butyrophenones / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005123:Eye / Q000098:blood supply* / Q000187:drug effects; D005901:Glaucoma / Q000188:drug therapy*; D006220:Haloperidol / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects; D010862:Pilocarpine / Q000494:pharmacology; D011817:Rabbits; D013999:Timolol / Q000494:pharmacology; D014272:Trifluperidol / Q000494:pharmacology
D002090:Butyrophenones; D010862:Pilocarpine; D013999:Timolol; D006220:Haloperidol; C005209:moperone; D014272:Trifluperidol