A differential sex effect of amphetamine on exploratory behavior in maturing mice.
The effects of amphetamine (5-20 mg/kg) were studied 60 min after injection in mice aged 2, 3, 4 and 6 weeks postpartum. Exploratory behavior as indicated by the "head poke" test was depressed at all ages, but appeared to be relatively uncomplicated by other effects at the 5 mg/kg dose. At 4 and 6 weeks control females showed significantly greater activity than males, and amphetamine produced a greater reduction for control levels than in males.
D000367:Age Factors; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects
D000661:Amphetamine; D004298:Dopamine