Acute poisoning by intentional ingestion of thallous malonate.
A 26-year-old man who ingested 10 g of thallous malonate was treated by gastric lavage and combined haemodialysis and haemoperfusion. At a blood flow of 100 ml/min, the average of thallium clearance values obtained by combined haemoperfusion and haemodialysis at two different times were 50.2 and 60.4 ml/min. Forty hours after ingestion, he died of cardiac failure. A higher concentration of thallium was found in the heart than in other organs, suggesting that the heart is the main target of thallium in the early stage of acute poisoning.
D000208:Acute Disease; D000328:Adult; D006321:Heart / Q000187:drug effects; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D006435:Renal Dialysis; D013406:Suicide, Attempted; D013793:Thallium / Q000097:blood / Q000506:poisoning*
D013793:Thallium