[Mechanism of organ damage in hyperthromboplastinemia unrelated to hypoxia].
Hyperthromboplastinemia in rats and dogs was induced by the infusion of xenogenic or allogenic brain suspension or extract. The suspension caused fatal blood coagulation due to fibrin-platelet isolation of cytolemma fractions. The infusion of extracts produced hypotension, caused by hyperkininemia, and primary hypocoagulation due to simultaneous fibrin-formation and fibrinolysis. Severe hepatic, renal and myocardial lesions were discovered 3-4 min after the allogenic brain extract infusion. Xenogenic brain infusion caused inverse changes. The mechanism of this phenomenon is unknown. The organs were affected by lysosomal enzymes activated not by hypoxia but by thrombin- and plasmin-induced glycocalix destruction.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000503:physiopathology; D004285:Dogs; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D007705:Kinins / Q000097:blood; D008297:Male; D009102:Multiple Organ Failure / Q000503:physiopathology*; D009417:Nerve Tissue / Q000637:transplantation; D051381:Rats; D013925:Thromboplastin / Q000502:physiology*; D013997:Time Factors; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D007705:Kinins; D013925:Thromboplastin
Ne sviazannyĭ s gipoksieĭ mekhanizm povrezhdeniia organov pri gipertromboplastinemii.