Structure of the carboxyl-terminal half of human alpha 2-plasmin inhibitor deduced from that of cDNA.
A 1.7 kilobase cDNA clone isolated from a human liver cDNA library contained 822 nucleotides encoding the carboxyl-terminal 274 amino acid sequence of alpha 2-plasmin inhibitor, a stop codon and a 3' noncoding region of 0.9 kilobases. The amino acid sequence deduced from the cDNA shows 29-31% homology with those of other plasma protease inhibitors. The inhibitor's putative reactive-site peptide bond was Met-Ser, and the Met residue was located at the 91st position from the carboxyl-terminal end. The plasminogen binding site was located in the carboxyl-terminal region.
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics*; D004274:DNA, Recombinant; D006801:Humans; D010446:Peptide Fragments / Q000235:genetics*; D000979:alpha-2-Antiplasmin / Q000235:genetics*
D004274:DNA, Recombinant; D010446:Peptide Fragments; D000979:alpha-2-Antiplasmin; D004247:DNA