title: High rate of affective disorders in probands with attention deficit disorder and in their relatives: a controlled family study.
abstract: In a controlled family study of attention deficit disorder, data were collected on first-degree relatives of 22 children with attention deficit disorder and 20 normal children. The rate of major affective disorder was significantly higher in the attention deficit disorder probands (32%) and their relatives (27%) than in the normal control subjects (0%) and their relatives (6%). The findings indicate that attention deficit disorder is associated with higher risk for affective disorder and suggest that probands who have both disorders may represent a distinct subgroup.
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000235:genetics*; D001714:Bipolar Disorder / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D012306:Risk