Granulocyte microbicidal function in patients undergoing major abdominal surgery under balanced anaesthesia.
Granulocyte microbicidal functions were studied in 11 major abdominal surgery patients with the luminol-enhanced chemiluminescence method. The responses of granulocytes in phagocytosis of zymosan, S. aureus and E. coli and responses to N-formylmethionyl-leucylphenylalanine (FMLP) were unaffected by surgery. The percentage of high-peroxidase-activity cells among neutrophils was increased on postoperative days 1 (P less than 0.01) and 3-4 (P less than 0.05). We propose that microbicidal-related oxidative phagocytic functions of granulocytes are well maintained after major abdominal surgery under balanced anaesthesia.
D000005:Abdomen / Q000601:surgery*; D000368:Aged; D000768:Anesthesia, General; D001770:Blood Bactericidal Activity; D004737:Enflurane; D005260:Female; D005283:Fentanyl; D006221:Halothane; D006801:Humans; D007958:Leukocyte Count; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D009609:Nitrous Oxide; D010544:Peroxidases / Q000097:blood; D010587:Phagocytosis
D004737:Enflurane; D010544:Peroxidases; D009609:Nitrous Oxide; D005283:Fentanyl; D006221:Halothane