Changes in the apparent chloride permeability of Necturus enterocytes during the sodium-coupled transport of alanine.
The membrane potential and intracellular Cl- activity of Necturus enterocytes were measured with double-barrelled ion-selective microelectrodes and apparent permeability coefficients (PCl) for the apical membrane calculated from Cl(-)-replacement experiments. In the presence of L-alanine in the mucosal solution an increase in PCl took place. It is proposed that this might reflect the activation of a Cl- conductance during active substrate transport.
D000409:Alanine / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000502:physiology; D007422:Intestines / Q000502:physiology*; D008564:Membrane Potentials; D009337:Necturus; D012964:Sodium / Q000494:pharmacology*
D002712:Chlorides; D012964:Sodium; D000409:Alanine