title: Pharmacokinetics of mezlocillin in patients with hepatobiliary dysfunction.
abstract: The pharmacokinetics of mezlocillin were investigated in 26 patients with alcoholic liver disease. Serum concentrations of mezlocillin were measured following intravenous administration of 3 g doses over 30 min. The mean peak serum concentration (+/- standard deviation) of mezlocillin at the end of infusion was 138.8 +/- 55.7 mg/l and the mean terminal half-life (T 1/2 beta) was 2.10 +/- 0.9 h. The 24 h urinary recovery of mezlocillin was 35.4 +/- 12.4% of the administered dose. Serum clearance was found to be inversely correlated with alkaline phosphatase and with total bilirubin. The T 1/2 beta was related to the following clinical measurements: age, SGOT and prothrombin time. This relationship suggests it may be prudent to adjust the dosage and the dosage interval of mezlocillin in patients with hepatobiliary dysfunction.
mesh_terms: D000328:Adult; D000368:Aged; D001660:Biliary Tract Diseases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D008802:Mezlocillin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged
chemical_list: D008802:Mezlocillin