title: Auranofin-associated colitis and eosinophilia.
abstract: Gold compounds, often used in the treatment of rheumatoid arthritis, have been associated with gastrointestinal disturbances in some patients. Use of auranofin, an oral gold preparation, in a 50-year-old woman with rheumatoid arthritis resulted in diarrhea, abdominal tenderness, nausea, and vomiting, which persisted despite discontinuation of auranofin therapy. The presumptive diagnosis was gold-induced colitis and eosinophilia. Administration of cromolyn sodium provided relief. Although this complication may be rare, evolving bowel symptoms in patients receiving auranofin demand prompt attention.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001310:Auranofin / Q000009:adverse effects* / Q000627:therapeutic use; D003092:Colitis / Q000139:chemically induced*; D004802:Eosinophilia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D001310:Auranofin