A critical evaluation of the urinary inhibiting activity in idiopathic calcium oxalate nephrolithiasis.
In order to obtain new insights into the relevance of inhibitors in whole urine by focusing on their reciprocal interactions, a statistical approach was followed in 35 controls and 27 calcium oxalate (CaOx) recurrent idiopathic stone formers. The inhibiting activity of CaOx crystal growth and the most widely accepted inhibitors (glycosaminoglycans, citrate, magnesium, pyrophosphate), stone constituents (calcium, oxalate, phosphate, urate) and other normal urinary substances were evaluated. It was seen that the inhibitors played a very small role in total inhibiting activity. On the other hand, considering other normal urinary constituents, almost all the inhibiting power of urine on crystal growth could be explained.
D000328:Adult; D002129:Calcium Oxalate / Q000378:metabolism; D002951:Citrates / Q000652:urine; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D009994:Osmolar Concentration; D014556:Urine / Q000502:physiology*
D002951:Citrates; D006025:Glycosaminoglycans; D002129:Calcium Oxalate