Induction of the plateau phase and rescue of MOPC 104E by nonspecific immunization.
The enhancement of MOPC 104E myeloma growth by nonspecific immunostimulation with C. parvum or immunization with sheep red blood cells and levan mixture was evaluated in BALB/c mice. We observed increased levels of serum MOPC 104E IgM and early mortality in the tumor-bearing mice following treatment with C. parvum or antigenic stimulation. The enhancement of tumor growth observed was due to the production of lymphokine mitogenic factors produced in response to the nonspecific immunostimulation.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002453:Cell Cycle; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use; D004912:Erythrocytes / Q000276:immunology; D005630:Fructans / Q000276:immunology; D006133:Growth Substances / Q000096:biosynthesis; D007114:Immunization; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D010954:Plasmacytoma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011425:Propionibacterium acnes / Q000276:immunology; D013154:Spleen / Q000276:immunology
D005630:Fructans; D006133:Growth Substances; D007075:Immunoglobulin M; D002945:Cisplatin