Transplacental passage of digoxin in the case of nonimmune hydrops fetalis.
Successful treatment of intrauterine fetal tachyarrhythmia was reported in several cases recently. It was also pointed out that placental transfer of digoxin is unsatisfactory under certain conditions. However, it has not been clearly shown in which cases fetal digoxin level does not reach the maternal level. We present a case of nonimmune hydrops fetalis due to congenital atrial flutter in which digoxin concentration in the sera of the mother and the neonate showed significant dissociation, and discuss perinatological matters about the digoxin treatment and the factor that obstructs the transplacental passage of digoxin. Conclusively, we recommend that maternal digoxin concentration should be raised to near toxic level if the resolution of fetal and placental hydrops is not attained in the initial digoxin loading.
D000328:Adult; D001282:Atrial Flutter / Q000151:congenital; D004077:Digoxin / Q000378:metabolism* / Q000627:therapeutic use; D004452:Echocardiography; D004487:Edema / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy / Q000378:metabolism*; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D012008:Recurrence
D004077:Digoxin