Antibody to sialosyllactosaminylparagloboside in a patient with IgM paraproteinemia and polyradiculoneuropathy.
Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma, reacted specifically with a ganglioside, sialosyllactosaminylparagloboside (SLPG), in human peripheral nerve but not with myelin-associated glycoprotein (MAG). This finding demonstrates the existence of anti-SLPG antibody in the patient's serum, suggesting that this antibody may play a role in the pathogenesis of neuropathy.
D000368:Aged; D000906:Antibodies / Q000032:analysis*; D002855:Chromatography, Thin Layer; D004797:Enzyme-Linked Immunosorbent Assay; D005732:Gangliosides / Q000378:metabolism; D005915:Globosides / Q000276:immunology*; D006028:Glycosphingolipids / Q000276:immunology*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000150:complications / Q000276:immunology*
D000906:Antibodies; D005732:Gangliosides; D005915:Globosides; D006028:Glycosphingolipids; D007075:Immunoglobulin M; C051587:sialosyllactosaminylparagloboside