title: [Heparin and the prevention of thromboembolism in surgery].
abstract: Heparin was introduced to medical prophylaxis against postoperative thromboembolic complications 50 years ago, following its discovery, structural elucidation, and first clinical use. Isolated subcutaneous application with and without control of coagulative data was followed by additional administration of dihydroergotamine. Results were thus substantially improved. The principle has now been scrutinised for the first time at the Surgical Hospital of Kiel University by computerised monitoring of large-scale application to more than 3,000 patients.
mesh_terms: D004087:Dihydroergotamine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D011183:Postoperative Complications / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000517:prevention & control*
chemical_list: D004087:Dihydroergotamine; D006493:Heparin
vernacular_title: Heparin zur Thromboembolieprophylaxe in der Chirurgie.