Regional cerebral blood flow changes associated with ethanol intoxication.
Regional cerebral blood flow (CBF) was measured via the 133Xenon inhalation technique in 26 healthy volunteers before and 60 minutes after the oral administration of ethyl alcohol or placebo on a double-blind basis. The cerebral blood flow values, corrected for test-retest differences in carbon dioxide showed a significant bilateral increase after ethanol administration. Blood levels of ethanol, estimated with a breath analyser, did not correlate with the CBF changes.
D000328:Adult; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004311:Double-Blind Method; D000431:Ethanol / Q000097:blood / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D000431:Ethanol