Hormonal effects and the control of gluconeogenesis from sorbitol, xylitol and glycerol in perfused chicken liver.
Addition of sorbitol or xylitol to perfused chicken liver caused a biphasic increase in the rate of glucose production. The second increase correlated with a decrease in the lactate to pyruvate ratio. Increased glucose production in response to the addition of glycerol was not biphasic. Aminooxyacetate inhibited both the inherent second increase in glucose production and stimulatory effects of alanine and pyruvate. The stimulatory effects of norepinephrine and glucagon on gluconeogenesis from sorbitol decreased in the presence of methylene blue. Only the stimulatory effect of norepinephrine was inhibited by aminooxyacetate.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D002645:Chickens; D005934:Glucagon / Q000494:pharmacology*; D005943:Gluconeogenesis / Q000187:drug effects*; D005990:Glycerol / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D013012:Sorbitol / Q000378:metabolism*; D014993:Xylitol / Q000378:metabolism*
D000625:Aminooxyacetic Acid; D013012:Sorbitol; D005934:Glucagon; D005990:Glycerol; D008751:Methylene Blue; D014993:Xylitol; D009638:Norepinephrine