3-[(2-ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity.
The 3-[(2-ethoxyphenoxy)methyl]piperidine derivatives 3-5 were synthesized and screened as potential antidepressant agents by the reserpine interaction test in mice and the evaluation of reuptake inhibition of biogenic amines in pig brain synaptosomal fractions. In addition, their anticonvulsant activity, tested by pentyleneetrazole antagonism, and approximate acute toxicity were evaluated. In vivo and in vitro tests showed that compounds 3 and 5 possess a biological activity comparable to that of the antidepressant drug viloxazine.
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001763:Blepharoptosis / Q000188:drug therapy; D001921:Brain / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005019:Ethyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D007035:Hypothermia / Q000188:drug therapy; D007202:Indicators and Reagents; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D012110:Reserpine / Q000037:antagonists & inhibitors; D012640:Seizures / Q000188:drug therapy; D012701:Serotonin / Q000378:metabolism; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014745:Viloxazine / Q000494:pharmacology
D000928:Antidepressive Agents; D005019:Ethyl Ethers; D007202:Indicators and Reagents; D010647:Phenyl Ethers; D010880:Piperidines; D012701:Serotonin; D014745:Viloxazine; D012110:Reserpine; D003891:Desipramine; D004298:Dopamine; D009638:Norepinephrine