Progression of minimal-change glomerulopathy to focal glomerulosclerosis in a patient with fenoprofen nephropathy.
We report a patient who presented with the classical features of fenoprofen-induced nephropathy. Initial response to a cessation of the drug and prednisone therapy was recovery of renal function, but proteinuria persisted. One year later, he experienced recurrence of the nephrotic syndrome with sustained renal failure. A clear progression from minimal-change lesions to focal glomerulosclerosis was shown in sequential renal biopsies. Not previously reported, this evolution is suggestive of the possibility that fenoprofen nephropathy may lead to chronic renal failure.
D001706:Biopsy; D005279:Fenoprofen / Q000009:adverse effects*; D005921:Glomerulonephritis / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications; D009402:Nephrosis, Lipoid / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000150:complications; D010666:Phenylpropionates / Q000009:adverse effects*; D011507:Proteinuria / Q000209:etiology
D010666:Phenylpropionates; D005279:Fenoprofen