[Morphometric and histochemical studies of the skeletal muscles of patients with chronic renal failure and dialysis patients].
In 19 patients with chronic renal insufficiency in the stage of compensated retention, 20 patients undergoing dialysis and 24 patients with normal renal function muscle tissue was taken by an open biopsy and investigated histologically, histochemically as well as morphometrically. A neurogenic atrophy stood in the foreground of the histologic changes of the striated musculature in uraemia, a pure type II atrophy was found more infrequently. In the patients undergoing dialysis frequency and size of these disturbances were more distinct. Except for a possible influence of a disturbed calcium metabolism other pathogenetic factors supposed in literature could not be found.
D000328:Adult; D001706:Biopsy; D002118:Calcium / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis; D014511:Uremia / Q000473:pathology
D010281:Parathyroid Hormone; D003402:Creatine Kinase; D002118:Calcium
Morphometrische und histochemische Untersuchungen der Skelettmuskulatur von Patienten mit chronischer Niereninsuffizienz und Dialysepatienten.