title: Extra-pancreatic effects of Momordica charantia in rats.
abstract: The extra pancreatic effects of the oral hypoglycaemic plant Momordica charantia have been investigated in rats. It was found that the fruit juice of this plant caused an increased glucose uptake by tissues in vitro without concomitant increase of tissue respiration. Oral treatment with the juice prior to a glucose load was found to increase the glycogen content of liver and muscle while it had no effect on the triglyceride content of adipose tissue. Pretreatment of fasted rats with M. charantia fruit juice had no significant effect on the gluconeogenic capacity of kidney slices. Similar results were obtained with kidney slices pre-incubated with M. charantia fruit juice.
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013188:Sri Lanka; D014280:Triglycerides / Q000096:biosynthesis
chemical_list: D007004:Hypoglycemic Agents; D014280:Triglycerides; D006003:Glycogen; D005947:Glucose