[Effect of corticosteroid hormones on the lymphoid system of vertebrates].
Studies have been made on cellular mechanisms of changes in the lymphatic organs of some vertebrates after the effect of hydrocortisone. The latter in a dose 100 mg/kg of the body mass significantly decreases the activity of the thymus in the tortoise Testudo horsfieldi, albino mice and frogs. The decrease in lymphopoiesis was also observed in the spleen and bone marrow. The duration of the latent period for the reaction of the lymphatic system is species specific. It amounts to 1-3 days in rats and mice, 3-5 days--in frogs and 5-10 days in tortoises. Possible mechanisms of these effects are discussed.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology*; D007958:Leukocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects*; D051379:Mice; D011895:Rana ridibunda; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors; D014426:Turtles
D006854:Hydrocortisone
Vliianie kortikosteroidnykh gormonov na limfoidnuiu sistemu u nekotorykh pozvonochnykh.