[The nonadrenergic noncholinergic system in the regulation of bronchial tonus].
Bronchial release appears to be regulated by the nonadrenergic noncholinergic system whose transmitter is very probably VIP. In vivo and in vitro studies were conducted to discover whether peptide modifies basic function and/or bronchial spasm provoked by histamine. The data collected show that VIP failed to cause bronchodilation but protects against histamine induced bronchoconstriction both in vivo and in vitro.
D000328:Adult; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D001986:Bronchial Spasm / Q000139:chemically induced; D006632:Histamine; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009129:Muscle Tonus / Q000187:drug effects; D013147:Spirometry; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology / Q000502:physiology
D014660:Vasoactive Intestinal Peptide; D006632:Histamine
Il sistema non-adrenergico non-colinergico nella regolazione del tono bronchiale.