Familial occurrence of lichen sclerosus et atrophicus. Case reports of a mother and daughter.
A mother and daughter with lichen sclerosus et atrophicus (LSA) are described. Both had lesions restricted to their lower legs. Both patients were positive for HLA-B40, which has been associated with LSA. Sex steroid hormones showed no decrease in dihydrotestosterone, free testosterone, or androstenedione levels in the daughter as was demonstrated in a previous study of this disease, but did show some decrease in androstenedione in the mother. This article provides further evidence for a possible familial predisposition for LSA.
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000235:genetics* / Q000473:pathology