title: Lentil lectin inhibits cells producing graft-versus-host reaction but does not suppress hematopoietic stem cells in mice.
abstract: Treatment of mouse donors or recipients of allogeneic spleen cells with repeated injections of lentil lectin markedly suppressed regional and systemic graft-versus-host reactions. The lectin acted selectively on lymphoid cells; hematopoietic stem cells were largely left unaffected. Repeated administration of the lectin decreased the number of lymphocytes and red blood cells and the amount of hemoglobin; other white blood cells increased in number.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D004906:Erythrocyte Count; D005260:Female; D006087:Graft vs Host Reaction; D006412:Hematopoietic Stem Cells; D007108:Immune Tolerance; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D037102:Lectins / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D007958:Leukocyte Count; D051379:Mice; D008815:Mice, Inbred Strains; D037121:Plant Lectins; D013154:Spleen / Q000166:cytology; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D000276:Adjuvants, Immunologic; D037102:Lectins; D037121:Plant Lectins; C033619:lentil lectin