title: Electrical stimulation of the hypothalamic nucleus paraventricularis mimics the effects of light on pineal melatonin synthesis.
abstract: In an attempt to clarify further the role of the hypothalamic paraventricular nuclei (PVN) in the control of pineal function, the effects of 2 min electrical stimulation of these nuclei were investigated in acutely blinded, adult, male Sprague-Dawley rats. Pineal serotonin-N-acetyltransferase (NAT) activity, melatonin content and catecholamine levels were measured by means of radio-enzymatic, radioimmunoassay and high-performance liquid-chromatography methods, respectively. All three pineal parameters underwent significant declines following brief PVN stimulation during the night time. These observations lend credence to the view that the neural pathways transmitting light information to the sympathetic innervation controlling pineal melatonin synthesis.
mesh_terms: D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000032:analysis; D002395:Catecholamines / Q000032:analysis; D004558:Electric Stimulation; D008027:Light; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology*; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002395:Catecholamines; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin