Verapamil and norverapamil in plasma and breast milk during breast feeding.
The concentrations of verapamil and norverapamil have been measured in milk and plasma samples from a 32 year-old woman treated with verapamil 80 mg tds while breast-feeding her child. The average steady-state concentrations of verapamil and noverapamil in milk were, respectively, 60% and 16% of the concentrations in plasma. The breast-fed child received less than 0.01% of the dose of verapamil given to the mother. No verapamil or norverapamil (less than 1 ng/ml) could be detected in the plasma from the child.
D000328:Adult; D001942:Breast Feeding; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008657:Metabolic Clearance Rate; D008895:Milk, Human / Q000032:analysis*; D014700:Verapamil / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
C016904:norverapamil; D014700:Verapamil