[Separation and pharmaco-toxicological studies of the enantiomers of Ifosfamide].
The enantiomers of ifosfamide were isolated chromatographically by the use of an optically active adsorbent. The biological activities of the racemic product and of the enantiomers (+)- and (-)-ifosfamide were compared as to the acute toxicity after single intraperitoneal administration on mice. Futhermore, the antitumor activity has been compared with regard to the rat leukemia L 5222 and the haematotoxicological effect. Under the conditions given, no biological differences between these 3 ifosfamide preparations were observed.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D001772:Blood Cell Count; D002846:Chromatography, Affinity / Q000379:methods; D005260:Female; D007069:Ifosfamide / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D007536:Isomerism; D007942:Leukemia, Experimental / Q000188:drug therapy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D007069:Ifosfamide
Präparative Trennung der Ifosfamid-Enantiomere und ihre pharmakologisch-toxikologische Untersuchung.