Heparin-associated hematomas: possible allergic reaction.
Heparin hypersensitivity is a rare complication of anticoagulation therapy. Our case involved a 34-year-old black male who demonstrated a hypersensitivity to porcine heparin that manifested as bilateral hematomas with ecchymoses from intravascular access sites. When bovine heparin was substituted, there was no evidence of a similar reaction. However, the patient required five times the usual dose to be adequately anticoagulated (partial thromboplastin time 1 1/2-2 times normal value) and eventually developed generalized pruritus.
D000328:Adult; D000818:Animals; D004342:Drug Hypersensitivity; D006406:Hematoma / Q000139:chemically induced*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013552:Swine
D006493:Heparin