Animal model for theophylline--cimetidine drug interaction.
Cimetidine (300 mg I.V.) and theophylline (15 mg/kg I.V.) were studied in Beagle dogs for possible drug interaction. The drugs were administered alone and in combination using a crossover design. Although none of the determined pharmacokinetic parameters for theophylline changed significantly in the presence of cimetidine, a trend towards significance was found for the terminal half-life, area under the curve, and mean residence time. The magnitude in changes found in Beagles is representative of the changes reported in man.
D000818:Animals; D002927:Cimetidine / Q000008:administration & dosage* / Q000097:blood; D004285:Dogs; D004347:Drug Interactions; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood
D002927:Cimetidine; D013806:Theophylline