Use of ammonium tetrathiomolybdate in the treatment of copper poisoning in sheep.
Intravenous administration of ammonium tetrathiomolybdate (three doses on alternate days) appeared to be an effective means of containing the acute phase of copper toxicity in sheep, whether this arose from continuous ingestion of high copper feeds or by injudicious use of copper preparations for the control of copper deficiency. No adverse effects were recorded on lamb numbers, birth weight or survival of lambs born to ewes of normal to low copper status when the treatment was applied at sensitive periods of the reproductive cycle. Decreases in 'available' plasma copper and in liver damage occurred rapidly in response to intravenous tetrathiomolybdate and it is suggested that all animals at risk be treated.
D000818:Animals; D003300:Copper / Q000097:blood / Q000506:poisoning*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008982:Molybdenum / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
D003300:Copper; D008982:Molybdenum; C020809:tetrathiomolybdate