title: Myopathy in Addison's disease.
abstract: Since the first description of primary adrenocortical insufficiency by Thomas Addison in 1855 several large series of patients with Addison's disease have been published. The common signs and symptoms include: weakness, hyperpigmentation, weight loss, gastrointestinal complaints, and hypotension. It is rare for patients with Addison's disease to present with musculoskeletal symptoms including flexion contractures, hyperkalaemic neuromyopathy, Guillain-Barré syndrome, migratory myalgia, sciatica-like pain, and low back pain. Myopathy has not been previously described in Addison's disease. Herein we report a patient presenting with severe hyponatraemia and myopathy which resolved after steroid replacement therapy.
mesh_terms: D000224:Addison Disease / Q000150:complications*; D000328:Adult; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology; D009135:Muscular Diseases / Q000209:etiology*