Acetone-induced changes in the toxicokinetics of 2,5-hexanedione in rabbits.
Male rabbits were intravenously injected with 2,5-hexanedione or 2,5-hexanedione plus acetone. A toxicokinetic analysis showed that a two-compartment model satisfactorily described the kinetics of 2,5-hexanedione in rabbits. Simultaneous dosing with acetone altered the toxicokinetic model which best described the plasma concentration versus time data. The model-independent parameter body clearance, calculated according to the trapezoidal rule, showed a decrease in the body clearance of 2,5-hexanedione in rabbits simultaneously injected with acetone. The results suggest that toxicokinetic interference may partly explain the neurotoxic potentiation of that which occurs in 2,5-hexanedione-induced axonopathy as a response to simultaneous exposure to acetone.
D000096:Acetone / Q000494:pharmacology*; D000818:Animals; D006588:Hexanones / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007659:Ketones / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009787:Occupational Medicine; D011817:Rabbits
D006588:Hexanones; D007659:Ketones; D000096:Acetone; C011269:2,5-hexanedione