Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes.
Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.
D000818:Animals; D005354:Fibrosarcoma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006183:H-2 Antigens / Q000235:genetics*; D008748:Methylcholanthrene; D051379:Mice; D009362:Neoplasm Metastasis; D014162:Transfection
D006183:H-2 Antigens; D008748:Methylcholanthrene