[Role of impaired regeneration of the mucosal epithelium in the pathogenesis of acute ulcers of the stomach and small intestine].
The method of modelling of acute gastric and small intestinal ulcers by intraperitoneal administration of vincristine at a dose of 0.15-0.30 mg/kg body weight is suggested. The method is based on the property of vincristine to stop mitotic cell division at the stage of metaphase, thus impairing regeneration of the epithelium in the stomach and small intestine. The experiments on 20 dogs have shown that single vincristine administration caused the accumulation of cells with nuclei at the stage of metaphase in the generative areas. Mucosa defects formed at these sites acquired all the features of acute ulcers by the third day. The model demonstrates the pathogenetic role of impaired mucous epithelium regeneration and permits the studies of pathogenesis of acute ulcer formation.
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007410:Intestinal Diseases / Q000209:etiology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007421:Intestine, Small; D012038:Regeneration / Q000187:drug effects*; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology; D014456:Ulcer / Q000209:etiology / Q000473:pathology; D014750:Vincristine / Q000633:toxicity
D014750:Vincristine
Rol' narusheniia regeneratsii épiteliia slizistoĭ obolochki v patogeneze ostrykh iaz zheludka i tonkoĭ kishki.