[Importance of the study of allergy and determination of the HLA group in the lipoid nephrosis in children. Study of 8 cases].
Eight children with steroid-response nephrotic syndrome were investigated to study the relation-ship between steroid responsive syndrome, allergy and HLA-antigens. Six of them had clinical and/or biological allergic symptoms. The allergen was identified in four out of six cases (grass-pollen 2 cases, house dust 1 case, frullania 1 case). Six children had DR7 HLA-antigen, five had B12 antigen. Three of the four children with cortico-dependent nephrotic syndrome have associated B12-DR7 HLA antigens. Search of an allergen seems to be of interest in children with steroid-responsive nephrotic syndrome, since eviction of the allergen may be proposed as a complement to cortico-therapy.
D002648:Child; D002675:Child, Preschool; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006684:HLA-DR Antigens / Q000032:analysis; D006239:Haplotypes; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000175:diagnosis; D007223:Infant; D009402:Nephrosis, Lipoid / Q000150:complications / Q000276:immunology*
D006680:HLA Antigens; D006684:HLA-DR Antigens
Intérêt de la recherche d'une allergie et de la détermination du groupe HLA dans la néphrose lipoidique de l'enfant. Etude de 8 cas.