title: Lack of association of HLA with thyroid cancer. An effect of iodine sufficiency and safe environment?
abstract: We examined HLA association with differentiated thyroid carcinoma in 45 patients from Newfoundland. No association was found. This finding contrasts with the description of an association of thyroid cancer with HLA-DR1 in Italy and Hungary (iodide deficient areas) and with DR7 in the American mid-west. We suggest that iodide deficiency predisposes DR1 + individuals to thyroid cancer and that this risk is negated by iodide sufficiency unless some other risk factor supervenes.
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000276:immunology; D001417:Background Radiation; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007455:Iodine / Q000502:physiology; D008297:Male; D009523:Newfoundland and Labrador; D011839:Radiation, Ionizing; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D007455:Iodine