Superficial spreading malignant melanoma with neurosarcomatous metastasis.
A case of neurosarcomatous nodal metastasis of superficial spreading malignant melanoma, without primary site desmoplasia or sarcomatous changes, is reported. Of particular interest regarding the metastasis are: the ultrastructural demonstration of numerous cytoplasmic microtubules, absence of premelanosomes, intense immunohistochemical reaction with S-100 protein antibody, and the presence, at the light microscopic level, of extranodal fibrosis. The primary lesion shows a pre-existing benign nevus and features suggestive of lamellar fibroplasia. The origin and histogenesis of melanocytic desmoplasia, in the context of a neural crest progenitor cell, and of lamellar fibroplasia, are discussed.
D000328:Adult; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D009455:Neurofibroma / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D009418:S100 Proteins