title: Concentrations of thiopentone in mature breast milk and colostrum following an induction dose.
abstract: In two groups of eight patients, concentrations of thiopentone in mature breast milk and colostrum following anaesthesia induction with 5.4 and 5.0 mg kg-1 b.w. (mean), respectively, were measured in the first 36 h postoperatively. Blood concentrations were measured simultaneously. The maximal concentrations were: in mature breast milk, 3.4 +/- 0.68 mumol l-1 (mean +/- s.e. mean) (0.090 mg 100 ml-1), and in colostrum, 1.3 +/- 0.5 mumol l-1 (0.034 mg 100 ml-1). The milk/plasma ratio was less than 1.0 in both groups. The above concentrations may be regarded as negligible and therefore non-toxic for the nursing infant.
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D000773:Anesthesia, Obstetrical; D001942:Breast Feeding; D002585:Cesarean Section; D002853:Chromatography, Liquid; D003126:Colostrum / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000032:analysis*; D011247:Pregnancy; D013514:Surgical Procedures, Operative; D013874:Thiopental / Q000032:analysis*
chemical_list: D013874:Thiopental