[Effect of vitamin A deficiency on the macromolecular permeability of small intestine mucosa in the adult rat].
Adult rats with experimental vitamin A deficiency and control animals were intraperitoneally injected with chicken ovalbumin (OA) solution and the entrance of native OA into the blood was assessed 3 hours later by competitive radioimmunoassay. The OA amounts circulating in the blood of control animals averaged (0.39 +/- 0.06) X 10(-4)% of the consumed dose, while in the experimental group it averaged (1.33 +/- 0.42) 10(-4)%. Electron microscopy, using colloid lanthanum hydroxide, has shown vitamin A deficiency to give rise to an abrupt reduction in glycocalix layer, as compared to the control, without increasing erythrocyte membrane permeability for tracer particles. It is concluded that vitamin A deficiency leads to a considerable damage of small intestinal permeability for protein macromolecules.
D000818:Animals; D002463:Cell Membrane Permeability; D003102:Colloids; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000648:ultrastructure; D007421:Intestine, Small / Q000378:metabolism* / Q000648:ultrastructure; D007811:Lanthanum / Q000378:metabolism; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D010047:Ovalbumin / Q000378:metabolism*; D051381:Rats; D014802:Vitamin A Deficiency / Q000378:metabolism* / Q000473:pathology
D003102:Colloids; D046911:Macromolecular Substances; C033562:lanthanum hydroxide; D007811:Lanthanum; D010047:Ovalbumin
Vliianie nedostatochnosti vitamina A na pronitsaemost' slizistoĭ obolochki tonkoĭ kishki vzroslykh krys dlia makromolekul.