D-pipecolic acid inhibits ethanol tolerance in mice.
The effects of graded doses of D-pipecolic acid (0.005-5 micrograms/animals s.c.) on tolerance to the hypothermic effect of ethanol (4 g/kg i.p.) were investigated in mice. D-Pipecolic acid itself did not change the core temperature or the acute hypothermic response to a single dose of ethanol. Repeated D-pipecolic acid administration, however, blocked the development of tolerance to the hypothermic effect of ethanol. The development of tolerance could be observed in the control group. It is assumed that D-pipecolic acid is capable of counteracting the tolerance effect of ethanol.
D000818:Animals; D001812:Blood-Brain Barrier; D001831:Body Temperature / Q000187:drug effects*; D004347:Drug Interactions; D004361:Drug Tolerance / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D010875:Pipecolic Acids / Q000008:administration & dosage*
D010875:Pipecolic Acids; D000431:Ethanol; C031345:pipecolic acid