Monacolin M, a new inhibitor of cholesterol biosynthesis.
Monacolin M, a new specific inhibitor of cholesterol biosynthesis structurally related to monacolin K (mevinolin), was isolated from cultures of a strain of Monascus ruber. The structure of monacolin M was determined to be beta-hydroxybutyryl ester of monacolin J by a combination of physical techniques. It was suggested that monacolin M is derived from monacolin J via a synthetic pathway distinct from that for the synthesis of monacolin K, alpha-methylbutyryl ester of monacolin J. The inhibitory effect of monacolin M on beta-hydroxy-beta-methylglutaryl-CoA reductase was slightly lower than that of monacolin K.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000924:Anticholesteremic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; C051483:monacolin M; C045374:monacolin X; D008148:Lovastatin