Pitrazepin: a central glycine and GABA antagonist.
In the spinal cord of the pentobarbitone-anaesthetised cat, microelectrophoretic pitrazepin reduced the inhibitory effects on neuronal firing of both glycine and GABA.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D003984:Dibenzazepines / Q000494:pharmacology*; D004586:Electrophoresis; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors*; D009474:Neurons / Q000187:drug effects
D003984:Dibenzazepines; D018756:GABA Antagonists; C041662:pitrazepin; D005998:Glycine; D001640:Bicuculline