title: Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates.
abstract: The previously presented consensus sequence for eukaryotic translation initiation sites by Kozak was derived substantially from vertebrate mRNA sequences. Drosophila nuclear genes exhibit a significantly different translation start consensus sequence. These differences probably do not represent mechanistic differences in translation initiation inasmuch as both taxa exhibit identical preferences and restrictions at the crucial -3 position. Using more conservative criteria for the assignment of consensus the following consensus sequences were derived: vertebrate--CANCAUG and Drosophila--CAAAACAUG.
mesh_terms: D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000235:genetics*; D005796:Genes; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D013045:Species Specificity; D014714:Vertebrates / Q000235:genetics*
chemical_list: D012333:RNA, Messenger