High-dose phenytoin in the treatment of refractory epilepsy.
Refractory, long-standing, high-frequency epilepsy was successfully managed with high-dose phenytoin treatment. Side effects were observed in only three patients and were easily corrected. Most of the patients had partial seizures, but many also had a myoclonic component. Emphasis was placed on monotherapy whenever possible. Results, interpretation of serum levels, and toxic reactions to phenytoin are discussed.
D000293:Adolescent; D000328:Adult; D002648:Child; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D010672:Phenytoin