Clearance of nasal mucus in nonanesthetized and anesthetized dogs.
Clearance rates for nasal mucus in the maxillary turbinate region were measured in 8 Beagle dogs. 99mTc Macroaggregated albumin (10 microliters) was instilled in the nasal maxillary region of dogs under general anesthesia. A gamma camera was used to detect movement of the 99mTc macroaggregated albumin in the nose for 1 hour after it was instilled. Velocity of mucus was measured in the 8 dogs each under 3 conditions of anesthesia: anesthesia with pentobarbital given IV (20 mg/kg of body weight), anesthesia with halothane gas, and no anesthesia. Mean velocities (+/- SD) were 3.7 +/- 1.4 mm/min in dogs anesthetized with pentobarbital, 4.3 +/- 2.5 mm/min in dogs anesthetized with halothane, and 3.4 +/- 1.7 mm/min in awake dogs. The differences between the 3 anesthetic conditions were not significant at the P less than 0.05 level. Use of anesthesia at a light surgical plane provides a controlled method for measurement of clearance of nasal mucus with minimal alterations from the nonanesthetized state.
D000818:Animals; D004285:Dogs / Q000378:metabolism*; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D009093:Mucus / Q000378:metabolism*; D009297:Nasal Mucosa / Q000187:drug effects / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology*; D013668:Technetium Tc 99m Aggregated Albumin / Q000378:metabolism
D013668:Technetium Tc 99m Aggregated Albumin; D010424:Pentobarbital; D006221:Halothane