Recurrent acute renal failure with interstitial nephritis due to D-penicillamine.
A 60-year-old man with rheumatoid arthritis, who developed acute reversible renal failure with nephrotic syndrome and tubulointerstitial nephritis in association with multiple-drug therapy, is described. The episode was ascribed to the nonsteroidal anti-inflammatory agent fenbufen, and the patient was reexposed to D-penicillamine within 6 months, reproducing the same renal lesion. There was no evidence of the glomerular lesions characteristically associated with D-penicillamine nephrotoxicity. D-penicillamine was the only drug therapy common to both episodes and it is concluded that it may cause tubulointerstitial nephritis with nephrotic syndrome.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000150:complications; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine