Diabetes insipidus associated with dysplastic pancytopenia.
This case report describes a 60-year-old man who presented with a three-year history of generalized malaise, decreased libido, polyuria, and polydipsia. He had been previously investigated for pancytopenia, and found to have a hypoplastic bone marrow. A diagnosis of central diabetes insipidus was established; the patient was also found to have a number of other defects in his hypothalamic-pituitary function. Hematologic studies again revealed peripheral pancytopenia associated with a hypoplastic megaloblastic bone marrow. Computed axial and nuclear magnetic resonance tomography failed to establish the nature of the morphologic lesion in the hypothalamus. A possible relationship between the hematologic and endocrine disturbance is discussed.
D001853:Bone Marrow / Q000473:pathology; D003919:Diabetes Insipidus / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007032:Hypothalamus, Anterior / Q000503:physiopathology; D008297:Male; D008534:Megaloblasts / Q000473:pathology; D008875:Middle Aged; D010198:Pancytopenia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D010902:Pituitary Gland / Q000503:physiopathology