title: [Action of ranitidine on changes in gastric pH during the perioperative period in cardiac surgery].
abstract: Any state of stress originates a reduction of gastric pH contributing to the development of digestive lesions. The objective of this prospective work was to evaluate in subjects having undergone a heart surgical procedure, the effect of an anti-H2 agent, ranitidine, on the changes with time of gastric pH during the first 24 hours following induced anaesthesia. Administered discontinuously intravenously, ranitidine was shown to have a clearcut effect on gastric pH, shifting the pH profiles towards higher values. This phenomenon proves to be statistically significant from the 12th hour following the beginning of anesthesia.
mesh_terms: D000328:Adult; D000368:Aged; D000758:Anesthesia; D006348:Cardiac Surgical Procedures; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011899:Ranitidine / Q000627:therapeutic use*
chemical_list: D011899:Ranitidine
vernacular_title: Action de la ranitidine sur l'évolution du pH-gastrique dans la période péri-opératoire de chirurgie cardiaque.