title: Thymic involvement in memory responses after primary challenge with TNP-Ficoll in Xenopus laevis, the South African clawed toad.
abstract: Memory to TNP-Ficoll in Xenopus laevis is demonstrable as a more rapid secondary response rather than an augmented response. While adult thymectomy abrogates ability to respond to both primary and secondary challenge with soluble TNP-Ficoll, memory to this antigen can be revealed in thymectomized animals by challenge with TNP-Ficoll on bentonite beads. Memory to TNP-Ficoll cannot be revealed by secondary challenge with TNP-LPS or TNP-RBC, but memory to TNP-LPS is revealed by TNP-Ficoll challenge. These results are consistent with the hypothesis that, whereas B1 cells (capable of responding to TI-2 antigens) can develop from a pool of B1 and B2 memory cells (generated in response to TD or TI-1 antigens), initial challenge with TI-2 antigen does not produce a pool containing both B-cell subsets.
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology; D003208:Concanavalin A / Q000276:immunology / Q000494:pharmacology; D005362:Ficoll / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D007117:Immunization, Secondary; D007156:Immunologic Memory / Q000187:drug effects*; D008211:Lymphocyte Cooperation / Q000187:drug effects; D009578:Nitrobenzenes / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D012397:Rosette Formation; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*; D014301:Trinitrobenzenes / Q000008:administration & dosage / Q000276:immunology*; D014982:Xenopus laevis / Q000276:immunology*
chemical_list: D000941:Antigens; D006241:Haptens; D009578:Nitrobenzenes; D011134:Polysaccharides; C020529:TNP-ficoll; D014301:Trinitrobenzenes; D003208:Concanavalin A; D005362:Ficoll