[Effect of infusion acidosis on the condition of the fetus--animal experiment studies].
In order to assess the effect of acid infusion on fetal cardiovascular functions, oxygenation, glucose and electrolyte concentrations, 8 experiments were performed on chronically instrumented ewes. A severe metabolic acidosis (pH less than 7.10, BDECF = 13.5 mmol/l) was induced by intravenous infusion of L(+) lactate into the fetus. There was no significant alteration of baseline fetal heart rate and oscillation amplitude. The blood pressure exhibited a slight increase, probably due to the administration of volume (87-204 ml in 90-210 min). PO2 remained constant while SO2 showed a decrease in the order of 10%, due to the change in oxygen affinity of the fetal blood produced by the Bohr effect. Levels of glucose increased significantly, whereas electrolyte concentrations remained unchanged. After the end of infusion, pH-values returned to the normal range within 110 min. Lactate and BDECF decreased with a half life time of 95 and 48 min, respectively (mean SO2 = 28%). We conclude that a severe metabolic acidosis in the extracellular space does not affect the normal fetal heart rate pattern (baseline, oscillation amplitude) and has no acute deleterious effects on the fetus. Hence, when the actual fetal pH during labor is found to be low, a maternogenic infusion acidosis should be excluded by a simultaneous feto-maternal blood gas analysis.
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology; D004573:Electrolytes / Q000097:blood; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology*; D006340:Heart Rate, Fetal; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D012756:Sheep
D001786:Blood Glucose; D004573:Electrolytes; D007773:Lactates; D019344:Lactic Acid; D010100:Oxygen
Einfluss der Infusionsazidose auf den Zustand des Feten--tierexperimentelle Untersuchungen.