[Experience in using cystamine for decreasing radiation disorders in Wistar rat embryogenesis].
In experiments on 340 primigravida Wistar rats and 1557 young rats of the first generation a study was made of toxicity and radioprotective efficiency of single subcutaneous injection of 100 mg/kg cystamine on days 3, 11 and 19 of pregnancy. In the control animals, the preparation caused different changes in the pregnancy course, delivery and postnatal development of posterity. The radioprotective properties of the preparation were only manifested when embryos were exposed to 3 Gy radiation (a lethal dose) during the preimplantation period, and it was less effective during the periods of organogenesis and fetus formation.
D000818:Animals; D003538:Cystamine / Q000627:therapeutic use* / Q000633:toxicity; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D047108:Embryonic Development / Q000187:drug effects / Q000528:radiation effects; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D011247:Pregnancy; D011833:Radiation Injuries, Experimental / Q000196:embryology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains / Q000196:embryology*; D013997:Time Factors
D003538:Cystamine
Opyt primeneniia tsistamina dlia snizheniia luchevykh narusheniĭ v émbriogeneze krys Vistar.