Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-hydroxy estrone and 2-hydroxy estradiol.
Catechol estrogens, 2-hydroxy estrone, 2-hydroxy estradiol and 2-hydroxy estriol, were tested as possible antioxidants of phospholipid peroxidation induced by Fe3+-ADP-adriamycin, using phospholipid liposomes as lipid source and alpha-tocopherol or other steroids as reference compounds. The parameters of antioxidant activities were: elongation of induction period, inhibition of O2 consumption required for lipid peroxidation and inhibition of peroxidative cleavage of unsaturated phospholipid. Of the tested compounds, 2-hydroxy estradiol or 2-hydroxy estrone had more potent activity than that of tocopherol.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004964:Estriol / Q000031:analogs & derivatives / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives*; D005290:Ferric Compounds / Q000494:pharmacology; D006894:Hydroxyestrones / Q000494:pharmacology*; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D005290:Ferric Compounds; D006894:Hydroxyestrones; D008054:Lipid Peroxides; D008081:Liposomes; D010743:Phospholipids; C040440:doxorubicin-ferric-ADP complex; C008012:2-hydroxyestriol; D014810:Vitamin E; D004970:Estrone; D004958:Estradiol; D000244:Adenosine Diphosphate; D004317:Doxorubicin; C001390:2-hydroxyestradiol; D004964:Estriol; C024980:2-hydroxyestrone