Alpha/beta value and the importance of size of dose per fraction for late complications in the supraglottic larynx.
In a group of 155 cases with squamous cell carcinoma of the supraglottic larynx (T3-4N0M0), with 3-year local control after radiotherapy, 21 late complications were noted. Using two different methods, an alpha/beta value of 3.8 Gy was calculated. A strong correlation between the risk of late effect in the larynx and size of dose per fraction was found; there was no influence of overall treatment time.
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D007830:Larynx / Q000528:radiation effects*; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage