Comparison of two benzodiazepines in the treatment of alcohol withdrawal: effects on symptoms and cognitive recovery.
Forty newly admitted alcohol-dependent patients were randomly allocated to equivalent 6-day regimes of either lorazepam or diazepam, to compare involvement in physical, emotional and cognitive state during the first 8 days in hospital. Diazepam provided a more comfortable withdrawal period and was associated with slightly better cognitive functioning on the eighth day.
D000328:Adult; D003071:Cognition / Q000187:drug effects; D003975:Diazepam / Q000627:therapeutic use*; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000523:psychology
D000431:Ethanol; D008140:Lorazepam; D003975:Diazepam