Peptidergic neurosecretory axons regenerate into sciatic nerve autografts in the rat hypothalamus.
Pieces of intact or degenerated sciatic nerves autografted into contact with transected neurosecretory axons within the hypothalamus were invaded by neurophysin-positive axons. With increasing time after grafting, increasing numbers of axons were present in both types of grafts, but grafts of degenerated sciatic nerves always contained more axons. At the fine-structural level typical neurosecretory as well as nonneurosecretory axons were usually associated with basal lamina-enclosed neurolemmocyte processes; occasional axons occurred among collagen fibrils or within basal lamina scaffolds. Profiles with the fine structural characteristics of axon terminals were present by 20 days after transplantation.
D000818:Animals; D001253:Astrocytes / Q000473:pathology; D007032:Hypothalamus, Anterior / Q000293:injuries* / Q000503:physiopathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009481:Neurophysins / Q000378:metabolism*; D010525:Peripheral Nerves / Q000637:transplantation*; D051381:Rats; D012038:Regeneration
D009481:Neurophysins