Influence of reserpine and guanethidine on the responses of the isolated rat ileum to catecholamines.
The sensitivity of the isolated ileum of the rat to catecholamines has been investigated using normal, reserpinized and guanethidine treated animals. Both reserpine and guanethidine treatment produces supersensitivity to adrenaline, noradrenaline and to a greater extent to isoprenaline.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004357:Drug Synergism; D006145:Guanethidine / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*
D002395:Catecholamines; D012110:Reserpine; D006145:Guanethidine