Ethanol-induced aneuploidy in male germ cells of the mouse.
The administration of alcohol to male mice 2-6 h before the preparation of second meiotic metaphases from testes resulted in an approximately six-fold increase in aneuploidy. The timing employed indicates that the observed chromosome abnormalities were a result of nondisjunction and/or anaphase lagging at the first meiotic division. A similar effect has been described in the female mouse; however, the present results suggest that the aneuploidy-inducing effect of ethanol may be substantially greater in the female than in the male.
D000782:Aneuploidy; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012737:Sex Factors; D013737:Testis / Q000187:drug effects / Q000648:ultrastructure*
D000431:Ethanol