Dimethylformamide (DMF) hepatotoxicity.
Scattered case reports of accidental exposure and a few epidemiological studies have indicated that the liver is the main target organ following acute and chronic exposure to dimethylformamide (DMF). This has been confirmed in several animal species. In humans, ethanol intolerance is one of the earliest manifestations of (excessive) exposure to DMF, followed at higher exposure levels by various complaints (nausea, vomiting, abdominal pain) and the release of liver cytolytic enzymes in the plasma. The metabolic pathway of DMF has been recently clarified, but the primary cellular lesion responsible for its hepatotoxicity is still unknown.
D000818:Animals; D004126:Dimethylformamide / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects*; D008247:Lysosomes / Q000032:analysis; D051379:Mice; D008854:Microscopy, Electron; D051381:Rats
D008054:Lipid Peroxides; D004126:Dimethylformamide; D005978:Glutathione