Human mammary carcinomas in nude rats--a new approach for investigating oxygen transport and substrate utilization in tumor tissues.
A new model is presented for the study of oxygen supply and substrate utilization in human tumor tissue. In this approach human tumor material thrives in immune-deficient nude rats. The host chosen allows the continuous evaluation of all relevant parameters. From the data obtained so far it is concluded that this model is a valid tool in investigation of the metabolic status of human tumors.
D000818:Animals; D001692:Biological Transport; D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D014183:Transplantation, Heterologous
D010100:Oxygen