[Genetic action of 131I and 125I on the germ cells of male mice].
A study was made of the genetic effects of iodine radioactive isotopes in male germ cells of (CBA X C57Bl)F1 hybrid mice. After a single intraperitoneal administration of Na131I (1.48 to 740 kBq/g) or Na125I (148 to 7400 kBq/g) to males the occurrence of dominant lethal mutations (DLM), reciprocal translocations (RT), and abnormal sperm heads (ASH) was studied. The radioactive iodine isotopes induced DLM at the postmeiotic spermatogenesis stages only. After the effect of the isotopes, the frequency of RT increased insignificantly with dose. The frequency of ASH was only increased with the highest 131I dose. Relative biological effectiveness of 131I and 125I was less than 1 with a reference to the indices under study.
D000818:Animals; D020964:Embryo Loss / Q000209:etiology / Q000235:genetics; D005260:Female; D005799:Genes, Dominant / Q000528:radiation effects; D005804:Genes, Lethal / Q000528:radiation effects; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008808:Mice, Inbred CBA / Q000235:genetics*; D009154:Mutation; D011247:Pregnancy; D012062:Relative Biological Effectiveness; D013077:Sperm Head / Q000002:abnormalities / Q000528:radiation effects; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000528:radiation effects
D007457:Iodine Radioisotopes
Geneticheskoe deĭstvie 131I i 125I na polovye kletki mysheĭ-samtsov.