Phenylethylamine metabolism to tyramine by postmortem human brain preparations.
Human brain preparations obtained from either the putamen, thalamus, hippocampus or lateral occipital gyrus p-hydroxylate phenylethylamine to tyramine, a reaction carried out by a microsomal (100,000 xg pellet) membrane bound, NADPH-requiring enzyme. This is a minor metabolic pathway occurring in chronic psychiatric patients, as well as in age-comparable controls.
D000368:Aged; D001921:Brain / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D001523:Mental Disorders / Q000378:metabolism; D008875:Middle Aged; D010627:Phenethylamines / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism*
D010627:Phenethylamines; D014439:Tyramine