title: [Regulation of terephthalate catabolism in Rhodococcus rubropertinctus].
abstract: The regulation of terephthalate catabolism was studied in Rhodococcus rubropertinctus which decomposed this synthetic monomer. The pathway (a) of terephthalate (TP) catabolism is as follows: TP----benzoate----4-hydroxybenzoate----protocatechuate----pyrocatechol-- --cycle ortho-cleavage. The following results were obtained when studying why two other catabolic pathways were realized if benzoate and 4-hydroxybenzoate were taken as a sole carbon source, namely, (b) benzoate----pyrocatechol----cycle cleavage and (c) 4-hydroxybenzoate----protocatechuate----cycle cleavage. TP seemed to cause the divergence of pathways (a) and (b) by repressing the system of benzoate oxidation to pyrocatechol. In pathway (c), benzoate repressed the synthesis of enzymes which catalysed protocatechuate oxidation. Pathway (b) was switched over to (a) when the strain was grown in a medium containing TP and benzoate at a benzoate concentration above 5 mM. Here, the concentration of benzoate (first exogenous and later formed from TP) played a key role. R. rubropertinctus growth in a medium with TP and glucose had diauxic characteristics.
mesh_terms: D001673:Biodegradation, Environmental; D004790:Enzyme Induction; D007700:Kinetics; D010084:Oxidation-Reduction; D010795:Phthalic Acids / Q000378:metabolism*; D012240:Rhodococcus / Q000201:enzymology / Q000378:metabolism*
chemical_list: D010795:Phthalic Acids; C011363:terephthalic acid
vernacular_title: Reguliatsiia katabolizma tereftalata u Rhodococcus rubropertinctus.