Plasma concentrations of ketanserin in chronic hemodialysed patients.
Six patients on chronic hemodialysis received 20 mg ketanserin p.o. twice daily for 3 days. Plasma levels were measured daily 2 hours after application of the morning dose; however, on the third day, plasma levels were taken before, during and after dialysis. On the 4th day elimination was measured after a single dose of 20 mg ketanserin for 24 hours. Mean plasma levels ranged from 19 to 31 ng/ml. Both ketanserin and reduced ketanserin were not eliminated by dialysis. Elimination half-life was about 12 hours.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007650:Ketanserin / Q000097:blood* / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007700:Kinetics; D008875:Middle Aged; D006435:Renal Dialysis
D007650:Ketanserin