[Changes in the fluorescence parameters of lipophilic probes bound to the erythrocyte membrane in cancer patients].
The fluorescence of intensivity of membrane-bound diphenylhexatriene (DFHT) of erythrocytes of the cancer patients is found to increase as compared to that of donors. No reliable differences are detected in a degree of fluorescence polarization of DFHT and pyren excimerization in erythrocyte membranes of cancer patients and donors. The data obtained show that under the development of malignant tumours the structure state of lipid bilayer of erythrocyte membrane does not undergo significant changes. However an increase of the fluorescence intensivity of the membrane-bound DFHT, evidently, is the result of changes in protein-lipid interactions in the membrane.
D004910:Erythrocyte Membrane / Q000032:analysis*; D005453:Fluorescence; D005456:Fluorescent Dyes; D006801:Humans; D008563:Membrane Lipids / Q000097:blood*; D009369:Neoplasms / Q000097:blood*
D005456:Fluorescent Dyes; D008563:Membrane Lipids
Ob izmenenii parametrov fluorestsentsii lipofil'nykh zondov, sviazannykh s membranami éritrotsitov krovi onkologicheskikh bol'nykh.