Effect of neuraminidase on Fc and C3b receptors on rabbit corneal cells infected with herpes simplex virus.
The effect of neuraminidase on Fc receptors (FcR) and C3b receptors (C3bR) was studied in epithelial, stromal and endothelial cells of the rabbit cornea infected with type 1 (HSV-1) and type 2 herpes simplex virus (HSV-2) in vitro. FcR were induced on epithelial, stromal and endothelial cells of the rabbit cornea by both HSV-1 and HSV-2, but their activities were not enhanced by neuraminidase. On the other hand, the treatment of HSV-infected corneal cells with neuraminidase resulted in the enhancement of C3bR activities on epithelial, stromal and endothelial cells infected with HSV-1, and the enhancing effect of neuraminidase was more pronounced on corneal endothelial cells. A similar neuraminidase treatment had no significant effect on C3bR activities on the corneal cells infected with HSV-2.
D000818:Animals; D003179:Complement C3b; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D066298:In Vitro Techniques; D007635:Keratitis, Dendritic / Q000378:metabolism* / Q000473:pathology; D009439:Neuraminidase / Q000494:pharmacology*; D011817:Rabbits; D011951:Receptors, Complement / Q000187:drug effects*; D011961:Receptors, Fc / Q000187:drug effects*
D011951:Receptors, Complement; D011961:Receptors, Fc; D003179:Complement C3b; D009439:Neuraminidase