Effect of piracetam on the electrocorticogram after traumatic brain oedema in cats.
The effect of piracetam on the electrocorticogram changes caused by experimentally-induced traumatic brain oedema in cats has been studied. The trauma was evoked by sticking a needle through the parietal associative cortical area. The electrocorticogram amplitude and frequency depression of the injured cortical area was eliminated and the bioelectrical activity restored to a normal pattern 22.4 +/- 10.3 min after a single dose of piracetam (100 mg/kg i.v.). The results indicate that piracetam recovered the cortical bioelectrical activity disturbed by experimentally-induced traumatic oedema. The beneficial effect of piracetam is probably due to an optimization of the functional state of the brain since piracetam acts as a nonspecific activator of brain excitability.
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004569:Electroencephalography; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*
D011760:Pyrrolidinones; D010889:Piracetam