Nuclear lipid peroxidation induced in rat liver by T-2 mycotoxin.
Oral administration to rats of T-2 mycotoxin (1.25 mg/kg) for five days causes an increase in lipid peroxidation (ascorbate-induced as well as NADPH-dependent) in hepatic nuclei, while the activity of liver glutathione-S-transferase (EC. 2.5.1.18) is decreased. The hepatotoxicity could be due to lipid peroxidation induced by depletion of hepatic reduced glutathione and/or production of free radicals.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology*; D013605:T-2 Toxin / Q000494:pharmacology*
D008054:Lipid Peroxides; D012717:Sesquiterpenes; D005982:Glutathione Transferase; D013605:T-2 Toxin