Behavioral effects of two dipeptides: L-phenylalanyl-L-arginine (Phe-L-Arg) and L-phenylalanyl-D-arginine (Phe-D-Arg) injected into the striatum or substantia nigra of rats.
Behavioral effects of two dipeptides: L-phenylalanyl-L-arginine (Phe-L-Arg) and L-phenylalanyl-D-arginine (Phe-D-Arg) on rat behavior after intrastriatal or intranigral injections were investigated. The L-L diastereoisomer of dipeptide (10-100 nmol) did not change the behavior while the L-D diastereoisomer induced clonic convulsions. Pretreatment by naloxone in a dose of 2 or 5 mg/kg prevented this effect. It is suggested that Phe-D-Arg might act via opioid receptors in nigrostriatal system.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D013237:Stereoisomerism; D013378:Substantia Nigra
D004151:Dipeptides; C048251:phenylalanylarginine