[Comparison of plaque reduction and active mouse protection tests for estimating the potency of Japanese encephalitis vaccine].
The plaque reduction test for assaying the potency of Japanese encephalitis vaccine was evaluated by comparing with the active mouse protection test. The relative potency of tested vaccine to the standard vaccine were 1.40 +/- 0.250 by the plaque reduction test with coefficient variation of 0.179 and 2.54 +/- 1.152 by the active mouse protection test with coefficient variation of 0.454. There was no significant difference between the plaque reduction and the active mouse protection test in term of relative potency, but the plaque reduction method had a better reproducibility. Furthermore, the plaque reduction method showed a higher sensitivity and time saving.
D000818:Animals; D004664:Encephalitis Virus, Japanese / Q000276:immunology*; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013696:Temperature; D010948:Viral Plaque Assay; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines