Synthesis of water-soluble, branched polysaccharides having D-mannopyranose, D-arabinofuranose, or oligo-D-arabinofuranose side-chains and their antitumor activity.
Branched polysaccharides having D-mannopyranose, D-arabinofuranose, or oligo-D-arabinofuranose side-chains were synthesized by the reaction of 3,4,6-tri-O-acetyl-(1,2-O-ethylorthoacetyl)-beta-D-mannopyranose, 3,5-di-O-benzoyl-(1,2-O-ethylorthobenzoyl)-beta-D-arabinofuranose, or 3-O-benzoyl-(1,2,5-O-orthobenzoyl)-beta-D-arabinofuranose with cellulose acetate or curdlan acetate, followed by desterification. The structure and antitumor activity of the water-soluble portion of the polysaccharides thus obtained were investigated. Polysaccharides synthesized from (1----3)-beta-D-glucan as the main chain with oligo-D-arabinofuranose side-chains exhibited high antitumor activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001089:Arabinose; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004353:Drug Evaluation, Preclinical; D007202:Indicators and Reagents; D008358:Mannose; D051379:Mice; D009844:Oligosaccharides; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D009844:Oligosaccharides; D011134:Polysaccharides; D001089:Arabinose; D008358:Mannose