[Effect of ascorbic acid on the frequency of the occurrence of colchicine- and methotrexate-resistant colonies].
The influence of ascorbic acid (vitamin C) on the frequency of occurrence of colchicine- and methotrexate-resistant colonies of Djungarian hamster DM-15 cells was studied the number of resistant cells was found to increase 2.9-19.8-fold. The genetic effect of using high vitamin C doses is discussed.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002273:Carcinogens; D002478:Cells, Cultured; D003078:Colchicine / Q000037:antagonists & inhibitors*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification / Q000187:drug effects; D008727:Methotrexate / Q000037:antagonists & inhibitors*; D014411:Neoplastic Stem Cells / Q000187:drug effects*
D002273:Carcinogens; D001205:Ascorbic Acid; D003078:Colchicine; D008727:Methotrexate
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