3H-norepinephrine release in hypothalamus and brainstem of Dahl-salt sensitive and resistant rats in vitro.
Electrically evoked 3H-norepinephrine release was measured in slices of hypothalamus and brainstem of Dahl-salt sensitive (Dahl-S) and Dahl-salt resistant (Dahl-R) rats on both high and low sodium chloride diets. Only those Dahl-S rats fed a high sodium chloride diet became hypertensive, systolic blood pressure above 150 mmHg, although the Dahl-S rats on a low sodium diet, and Dahl-R rats fed a high sodium diet, both had blood pressures that were elevated compared to the Dahl-R rats maintained on a low sodium diet, when measured at the time of sacrifice. The Dahl-S rats on a high sodium diet also showed an enhancement in the field-stimulation induced release of 3H-norepinephrine in the posterior hypothalamus. Evoked 3H-norepinephrine release was not altered in low sodium diet Dahl-S rats or in low or high sodium salt Dahl-R rats. The stimulation induced 3H-norepinephrine release was also not different in the anterior hypothalamus or the A2 region of the nucleus tractus solitarius in either Dahl-S or Dahl-R animals on either sodium chloride diet. These results suggest that the alteration of evoked 3H-norepinephrine release, specifically in the posterior hypothalamus may play a role in the development and/or maintenance of hypertension.
D000818:Animals; D001794:Blood Pressure; D001933:Brain Stem / Q000378:metabolism*; D004039:Diet, Sodium-Restricted; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000378:metabolism*; D007034:Hypothalamus, Posterior / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009638:Norepinephrine