[Proliferative activity, DNA synthesis and reproductive death of immediate and late progeny of irradiated cells].
In experiments on HeLa cells a study was made of a change in the rate of DNA synthesis, proliferative activity and reproductive death of exposed cells and their descendants throughout a number of generations. The rate of DNA synthesis decreased in 4 postirradiation generations, and a maximum inhibition (by 50%) was registered 48 h following irradiation. The proliferative activity of the irradiated cell descendants markedly decreased throughout 18-20 generations resulting in an increased death rate and a loss of cells from a generation. It is suggested that even the distant descendants (18-20 generations) of expose cells exhibited some lesions which may, in time, become fatal events leading to cell death.
D001345:Autoradiography; D002452:Cell Count / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D005720:Gamma Rays; D006367:HeLa Cells; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D013997:Time Factors
D004247:DNA
Proliferativnaia aktivnost', sintez DNKA i reproduktivnaia gibel' blizhaĭshikh i otdalennykh potomkov obluchennykh kletok.