[Acute interstitial nephritis and uveitis in the adult: apropos of 3 cases].
Acute renal failure due to tubulo-interstitial nephritis accompanied by uveitis has been observed in 3 young women (TINU syndrome). In these 3 cases, the nephropathy was preceded (1-3 months) by asthenia, anorexia, weight loss and a major inflammatory syndrome. Nonsteroidal anti-inflammatory drugs (NSAID) administration was noted. In 2 cases, uveitis appeared after the nephropathy had subsided. Renal biopsies performed in the 3 patients revealed mainly interstitial changes with mononuclear cell infiltration; immunofluorescence studies were negative. Although the severity of renal failure varied among patients, renal function recovered completely, returning to normal within 2, 3 and 24 months respectively, on corticosteroid therapy. The TINU syndrome is a rare situation compared to drug-induced acute interstitial nephritis, including NSAID related-nephritis. However, the real incidence of this syndrome might be underestimated since the uveitis can appear a few weeks later and its origin may not be related to the renal episode.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014605:Uveitis / Q000150:complications*
D011241:Prednisone
Néphrite interstitielle aiguë avec uvéite chez l'adulte: à propos de trois observations.