title: Quantitative evaluation of heterochromatin in epithelial atypia by an image processing method.
abstract: Digital image analysis as a method enabling quantitative description of microscopical images is especially important in studying cellular atypia. However, by using that method for characterizing the complex chromatin structure and its changes during atypia considerable difficulties arise. Defining substructures of chromatin images we have developed new method for description chromatin structure based on locally adaptive thresholding. The results obtained suggest that typical for atypia are changes in the size, optical density and distribution of the high optical density regions (heterochromatin) identified within the cell nuclei.
mesh_terms: D002843:Chromatin / Q000648:ultrastructure; D003201:Computers; D004847:Epithelial Cells; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000648:ultrastructure
chemical_list: D002843:Chromatin; D006570:Heterochromatin