[Dose-dependent effect of mezaton on kidney and heart functions].
In unanesthetized dogs within 20 min after intravenous administration of 0.05 mg/kg of mezaton an increase of diuresis, the rate of glomerular filtration, effective renal plasma flow, filtration fraction, sodium and potassium excretion by the kidneys was observed. The dose of 0.5 mg/kg of mezaton produced the opposite changes. In the experiments on frogs mezaton administration in a dose of 200 mg/kg exerted the positive inotropic effect.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010656:Phenylephrine / Q000494:pharmacology*; D011898:Ranidae; D013268:Stimulation, Chemical; D013566:Sympathomimetics / Q000494:pharmacology*
D013566:Sympathomimetics; D010656:Phenylephrine
Dozozavisimoe vliianie mezatona na funktsiiu pochek i serdtsa.