[Mechanism of activation of the external pathway of NADH oxidation in myocardial mitochondria during hemorrhagic shock].
The changes in the oxidative metabolism of rabbit myocardium in hemorrhagic shock were studied. The external pathway of NADH oxidation was shown to be activated, while the rates of glutamate oxidation in the presence of an uncoupler were diminished as compared to control values. These changes are probably due to the activation of phospholipase A2 and lipid peroxidation, since their inhibitors eliminate with the same efficiency the activation of the external pathway of NADH oxidation both in normal and damaged myocardium.
D000818:Animals; D004734:Energy Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D010084:Oxidation-Reduction; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism; D054467:Phospholipases A2; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000378:metabolism*
D008054:Lipid Peroxides; D009243:NAD; D010741:Phospholipases A; D054467:Phospholipases A2
Mekhanizm aktivatsii vneshnego puti okisleniia NADH v mitokhondriiakh miokarda pri gemorragicheskom shoke.