Polymorphous ventricular tachycardia due to alpha-blockade.
We report a case of polymorphous ventricular tachycardia caused by treatment with the post-synaptic alpha-blocking agent indoramin. This has not been reported with indoramin previously, nor to our knowledge with any other alpha-blocker. This pro-arrhythmic effect appears to be related to its class 3 anti-arrhythmic properties (QT interval prolongation) which is dose dependent, occurring only at large doses.
D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004244:Dizziness / Q000188:drug therapy; D004562:Electrocardiography; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D007217:Indoramin / Q000009:adverse effects*; D008133:Long QT Syndrome / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D013575:Syncope / Q000139:chemically induced*; D013610:Tachycardia / Q000139:chemically induced*
D007211:Indoles; D007217:Indoramin