Biliary excretion and organ distribution of 14C radioactivity after 14C-2-ethylhexyl acrylate administration in rats.
Rats were intravenously administered (14C)-2-ethylhexyl acrylate at the dose 10 mg/kg or 50 mg/kg b. w. Biliary excretion of 14C-radioactivity was followed in 1-3 hour intervals within the first 24 hours after administration. The rats were then sacrificed and distribution of 14C-radioactivity was followed in some organs. Highest radioactivity was found in liver, less in the kidneys and the least in the brain. A significant increase of bile flow was observed. In the 24-hour intervals 2.2% of the dose was eliminated via bile at both dosages, most of it (83%) during the first 3 hours.
D000179:Acrylates / Q000378:metabolism*; D000395:Air Pollutants, Occupational / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005978:Glutathione / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000179:Acrylates; D000395:Air Pollutants, Occupational; D002250:Carbon Radioisotopes; D005978:Glutathione; C036758:2-ethylhexyl acrylate