[Plasma levels of clomipramine and declomipramine in patients with depression: a study of its correlation with therapeutic efficacy].
Twenty four in-patients with an endogenous or non endogenous depressive syndrome (9 and 15, respectively) were treated in hospital for 21 days with various dosages regimens of clomipramine. Plasma concentrations of clomipramine and demethylclomipramine were determined once a week in blood samples. Therapeutic effects were assessed with Hamilton Rating Scale. At day 21, optimal therapeutic effect was observed when the sum of clomipramine and demethylclomipramine plasma levels was situated between 200-400 ng/ml.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002997:Clomipramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014149:Tranquilizing Agents / Q000008:administration & dosage
D014149:Tranquilizing Agents; C012273:desmethylclomipramine; D002997:Clomipramine
Concentrations plasmatiques de clomipramine et de déclomipramine chez des patients atteints de dépression: recherche de corrélations avec l'efficacité thérapeutique.