[Peripheral hemodynamics and metabolic parameters influenced by amrinone at rest and following handgrip stress].
Peripheral hemodynamics and metabolic parameters were studied in 12 healthy volunteers (mean = 24.6 years) and in 12 patients with coronary artery disease (mean = 51.1 years) at rest and after isometric handgrip exercise both before and after application of amrinone (1.5 mg/kg body weight i.v.). Amrinone produced a significant decrease in diastolic blood pressure during handgrip in patients and in volunteers by 10%. Heart rate increased by 4 to 8%. After application of amrinone there was a pronounced increase in forearm blood flow at rest by 50% and after handgrip by 30%. Amrinone is an effective vasodilator without altering systolic and mean arterial blood pressure or heart rate strongly. Amrinone did not influence metabolic parameters.
D000293:Adolescent; D000328:Adult; D000676:Amrinone / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004734:Energy Metabolism / Q000187:drug effects; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects
D000676:Amrinone; D009638:Norepinephrine; D004837:Epinephrine
Periphere Hämodynamik und metabolische Parameter unter dem Einfluss von Amrinon in Ruhe und nach Handgrip-Belastung.