[Effect of neonatal castration on sex steroid receptor levels in the hypophysis of male rats].
The content of estradiol and testosterone cytosolic and nuclear receptors has been studied in the pituitary body of adult male rats gonadectomized on day 1-3 after birth (long-term castrates) or in adulthood (short-term castrates). Intact male rats and long- and short-term castrates had the same level of cytosolic and nuclear estrogen receptors. The number of cytoplasmic and nuclear testosterone-binding sites was identical in the pituitary body of adult intact mice and long-term castrates. Contrastingly, the concentrations of androgen cytosolic and nuclear receptors were significantly lower in neonatally castrated males compared to intact adult animals. The results obtained indicate that nuclear testosterone receptors in the pituitary body mediate negative feedback effect of androgen on the release of luteinizing hormone and that the formation of thin mechanism occurs within the first days of life.
D000818:Animals; D000831:Animals, Newborn; D002467:Cell Nucleus / Q000032:analysis / Q000378:metabolism; D003600:Cytosol / Q000032:analysis / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D010902:Pituitary Gland / Q000032:analysis* / Q000378:metabolism; D051381:Rats; D011944:Receptors, Androgen; D011959:Receptors, Estradiol / Q000032:analysis* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D011987:Receptors, Steroid; D013739:Testosterone; D004958:Estradiol
Vliianie neonatal'noĭ kastratsii na uroven' retseptorov polovykh steroidov v gipofize krys-samtsov.