title: Comments on mean residence time determination.
abstract: In a recent paper, D. O. Chanter challenged the applicability of the use of statistical moments in estimating mean residence time and proposed an alternative approach. Errors in that paper are pointed out which involve the improper equating of whole-body amount of drug with plasma amount of drug in a kinetic system. The theory for the two methods discussed by Chanter is presented in a pharmacokinetic context.
mesh_terms: D001822:Body Burden; D005163:Factor Analysis, Statistical; D006801:Humans; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations