[Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment].
In experiments with murine and rat transplantable tumors, Scutellaria baicalensis Georgii extract treatment was shown to ameliorate cyclophosphamide and 5-fluorouracil-induced myelotoxicity and to decrease tumor cell viability. This was partly attributed to a pronounced antistressor action of the extract and its normalizing effect on some homeostatic parameters.
D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D003520:Cyclophosphamide; D005472:Fluorouracil
Povyshenie izbiratel'nosti deĭstviia tsitostatikov tsiklofosfana i 5-ftoruratsila s pomoshch'iu ékstrakta shlemnika baĭkal'skogo v éksperimente.