Cyclopia and maternal ingestion of salicylates.
Salicylates are teratogens in animals, but their teratogenicity in man remains controverted. The possibility that massive oral intake in the first 3 months of pregnancy may induce malformations has not been eliminated. We report a second case of cyclopia associated with daily maternal ingestion of up to 4 g of acetylsalicylic acid in the first trimester.
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000015:Abnormalities, Multiple / Q000139:chemically induced; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000002:abnormalities; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009666:Nose / Q000002:abnormalities; D009915:Orbit / Q000002:abnormalities*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D001241:Aspirin