title: Effects of nasopharyngeal cocaine or pharyngeal benzocaine on esophageal motility.
abstract: The esophageal effect of topical anesthetics applied to the nasopharynx was evaluated. Eight healthy volunteers underwent an esophageal motility study after each of the following: no anesthesia, 5% cocaine solution applied to the nasopharynx, and 20% benzocaine spray applied to the pharynx. Upper esophageal sphincter relaxation was prolonged after use of the 5% cocaine solution. No other significant effects on esophageal motility or pressures were noted.
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000772:Anesthesia, Local; D001566:Benzocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D009305:Nasopharynx
chemical_list: D003042:Cocaine; D001566:Benzocaine