Induction of oral cavity cancer by 3-diazotyramine, a nitrosated product of tyramine present in foods.
A mutagenic nitrosation product of tyramine, 4-(2-aminoethyl)-6-diazo-2,4-cyclohexadienone (3-diazotyramine, 3-DT) preferentially induced tumors of the oral cavity. Squamous-cell carcinomas of the mucosa of the oral cavity floor developed in 19 out of 28 male F344 rats administered 0.1% 3-DT in their drinking water. Tyramine and nitrite are found at fairly high concentrations in various foods. This demonstration of the carcinogenicity of 3-DT indicates that although the implications of 3-DT for human cancer are not clear, other nitrosable mutagen precursors need to be tested as possible risk factors in human cancer.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell; D005506:Food Contamination; D008297:Male; D009062:Mouth Neoplasms / Q000139:chemically induced*; D009153:Mutagens; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D014439:Tyramine / Q000031:analogs & derivatives* / Q000633:toxicity
D002273:Carcinogens; D009153:Mutagens; C051069:3-diazotyramine; D014439:Tyramine