title: Sensitivity of mouse Skh:HR-2 to ultraviolet radiation: melanocyte inactivation.
abstract: The hairless mouse, Skh:HR-2, was exposed to doses of ultraviolet (UV) radiation known to induce skin pigmentation. Three parameters associated with perturbations in skin pigmentation were monitored following UV exposure. These include spectroscopy (skin darkness), histology (melanocyte density), and biochemistry (melanin). Within 90 min of UV exposure, the skin became lighter. This was associated with a reduction of quantifiable melanin and the inactivation of epidermal melanocytes.
mesh_terms: D000818:Animals; D005260:Female; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000528:radiation effects*; D051379:Mice; D008812:Mice, Hairless; D011836:Radiation Tolerance; D012867:Skin / Q000378:metabolism; D012880:Skin Pigmentation / Q000528:radiation effects; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D008543:Melanins