Long-term follow-up of histamine turnover in mastocytosis.
To study the long-term histamine turnover in patients with mastocytosis, the urinary excretion of the main histamine metabolite tele-methylimidazoleacetic acid was measured. Eighteen patients, 10 with urticaria pigmentosa and 8 with systemic mastocytosis, were followed for several years (mean 4.2 years). Younger individuals (less than 30 years) had initially normal excretion or tended to normalize their excretion during follow-up, while older patients (greater than 30 years) often had systemic manifestations and higher excretion values, which increased in some cases during the observation period.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006632:Histamine / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008415:Mastocytosis / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged
D007093:Imidazoles; C002667:methylimidazoleacetic acid; D006632:Histamine