[Fundamental studies on the properties of a new adriamycin delivery system involving adsorption to activated carbon particles].
Adriamycin (ADM) was absorbed onto fine particles of activated charcoal. The characteristics of this newly developed drug delivery system were then examined in vitro. Eighty micrograms of ADM was released from the charcoal reversibly, and the biological activity of ADM released from the charcoal was retained perfectly. The ADM was released so slowly and continuously that the concentration of ADM around the charcoal particles remained high for a long time. Such characteristics suggested that ADM-CH may be available for the treatment of peritonitis carcinomatosa and lymph node metastases.
D000327:Adsorption; D002606:Charcoal; D003692:Delayed-Action Preparations; D004317:Doxorubicin; D066298:In Vitro Techniques
D003692:Delayed-Action Preparations; D002606:Charcoal; D004317:Doxorubicin