[Ultrastructural diagnosis of changes in the human myocardium during protection of the heart with cardioplegic solutions].
Results of qualitative and quantitative assessment of myocardial changes are presented based on examinations of 180 cardiobiopsy specimens taken from 58 patients with acquired heart diseases during open-heart surgery. For quantitative assessment of intracellular organelle changes a 6-score scale has been developed by means of which the time course of injury to the major cellular components was studied: before aortal clamping, at the height of ischemia, and during reperfusion. Basing on the integral assessment of structural changes it is possible to assess the severity of myocardial damage; such approach is valuable in the assessment of the efficacy of cardioplegic solutions in the clinical practice.
D002467:Cell Nucleus / Q000648:ultrastructure; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D006324:Heart Arrest, Induced; D006801:Humans; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure
Ul'trastrukturnaia diagnostika izmeneniĭ miokarda cheloveka pri zashchite serdtsa kardioplegicheskimi rastvorami.