Olfactory adenylate cyclase of the rat. Stimulation by odorants and inhibition by Ca2+.
Membranes prepared from the olfactory mucosa of the rat show a high level of adenylate cyclase activity. The activity increases up to 2-fold in the presence of physiologically relevant concentrations of odorants and is inhibited by Ca2+. The level of cyclase activity found is sufficient to explain the speed of olfactory transduction, which occurs on a time scale of tens of milliseconds.
D000098:Acetophenones / Q000494:pharmacology*; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D000081005:Cyclohexane Monoterpenes; D008297:Male; D039821:Monoterpenes; D009831:Olfactory Mucosa / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology*
D000098:Acetophenones; D000081005:Cyclohexane Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; C006923:carvone; D000262:Adenylyl Cyclases; C038699:acetophenone; D002118:Calcium