title: An evaluation of the efficacy of netobimin against Dicrocoelium dendriticum in sheep.
abstract: A trial was carried out to assess the efficacy of a nitrophenylguanidine compound, netobimin against Dicrocoelium dendriticum in naturally infected sheep. At a dose rate of 20 mg/kg bodyweight administered orally the drug was highly effective, producing a mean reduction of 98.9 per cent in the fluke burdens of treated animals compared with untreated controls. No side effects were observed in the treated sheep.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004011:Dicrocoeliasis / Q000188:drug therapy / Q000662:veterinary*; D004013:Dicrocoelium / Q000187:drug effects; D005704:Gallbladder / Q000469:parasitology; D006146:Guanidines / Q000627:therapeutic use*; D007421:Intestine, Small / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*
chemical_list: D000871:Anthelmintics; D006146:Guanidines; C049626:netobimin