The effects of short-chain fatty acids on the neuronal membrane functions of Helix pomatia. III. 22Na efflux from the cells.
The effect of short-chain fatty acids on both ouabain-sensitive and ouabain-insensitive fractions of 22Na efflux from the neurons of Helix pomatia was studied. Fatty acids, having fewer than 10 carbon atoms in the hydrocarbon chain, increased the ouabain-sensitive 22Na efflux from the neurons, while fatty acids, having more than 9 carbon atoms, inhibited the 22Na efflux in comparison with that in normal physiological solution. All the fatty acids used had an inhibiting effect on the ouabain-insensitive 22Na efflux from the cells independent on the number of carbon atoms in the hydrocarbon chain. These studies indicate that these short-chain fatty acids can be effective modulators of both ouabain-sensitive and ouabain-insensitive fractions of Na efflux from the cells.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D005227:Fatty Acids / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005724:Ganglia / Q000166:cytology / Q000378:metabolism; D006372:Helix, Snails; D066298:In Vitro Techniques; D009474:Neurons / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D010042:Ouabain / Q000494:pharmacology; D010421:Pentanoic Acids / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D012979:Sodium Radioisotopes
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010421:Pentanoic Acids; D012979:Sodium Radioisotopes; D010042:Ouabain; D012964:Sodium; C038780:n-pentanoic acid