Inhibition and reversal of denervation-induced atrophy by the beta-agonist growth promoter, clenbuterol.
Dietary administration of the growth promoter, clenbuterol, ameliorated denervation-induced atrophy in rat soleus muscles. In acutely denervated muscles the drug inhibited the appearance of atrophy, and in chronically denervated muscles the atrophy was almost fully reversed. Responses in slow twitch oxidative fibres were particularly marked.
D000818:Animals; D002976:Clenbuterol / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D006019:Glycolysis; D008297:Male; D009119:Muscle Contraction; D009121:Muscle Denervation; D024510:Muscle Development; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects; D009133:Muscular Atrophy / Q000188:drug therapy* / Q000473:pathology; D051381:Rats
D004983:Ethanolamines; D009124:Muscle Proteins; D002976:Clenbuterol