Intravenous self-administration of ethanol and acetaldehyde by rats.
Fisher strain rats were allowed to self-administer 2, 6, and 18 microM/kg/infusion of ethanol and acetaldehyde into the jugular vein for 22 to 28 days. Thirty-three percent of the rats self-administered 18 microM/kg/infusion of ethanol. Thirty-three, 40, and 33 percent of the rats initiated self-administration of 2, 6, and 18 microM/kg/infusion of acetaldehyde, respectively. It is suggested that acetaldehyde may possess stronger reinforcing effects than ethanol in intravenous self-administration by rats.
D000079:Acetaldehyde / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D012054:Reinforcement, Psychology; D012646:Self Administration
D000431:Ethanol; D000079:Acetaldehyde