Granular cell myoma and schwannoma: fine structural and immunohistochemical study.
We present the histological, ultrastructural, and immunohistochemical findings of two granular cell tumors of different histogenesis: a mediastinal granular cell schwannoma, and an uterine granular cell leiomyoma. Ultrastructurally the mediastinal tumor showed granular cell changes of the Schwann cells which were reactive for S-100 protein and Leu 7 antigen, but not for actin, desmin, CEA, EMA, or cytokeratin. Ultrastructural study of the uterine lesion demonstrated smooth muscle cells with only a few "autophagic" facuoles to cells nearly replaced by lysosomes. Immunohistochemically this tumor showed reactivity for actin, desmin, and Leu 7 antigen, but was S-100 protein, CEA, EMA, and cytokeratin negative.
D000293:Adolescent; D005260:Female; D006098:Granulocytes / Q000648:ultrastructure*; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D007889:Leiomyoma / Q000378:metabolism / Q000648:ultrastructure*; D008479:Mediastinal Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism / Q000648:ultrastructure*; D014594:Uterine Neoplasms / Q000378:metabolism / Q000648:ultrastructure*