[Comparison of the physicochemical properties of model immune complexes from normal and myeloma proteins].
Physico-chemical properties of model immune complexes from normal and myeloma immunoglobulins were compared, and complement-binding activity of these aggregates was studied. No considerable differences were observed between aggregates from normal and myeloma Ig. Myeloma complexes have a higher complement-binding activity, as compared to normal ones, and are structurally more stable. Complement-binding activity of both types of complexes depends on the complex molecular mass and is maximal in complexes of medium molecular mass.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003165:Complement System Proteins / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007834:Lasers; D008970:Molecular Weight; D009101:Multiple Myeloma / Q000097:blood; D009194:Myeloma Proteins / Q000378:metabolism*; D009391:Nephelometry and Turbidimetry; D013814:Thermal Conductivity
D000936:Antigen-Antibody Complex; D001798:Blood Proteins; D009194:Myeloma Proteins; D003165:Complement System Proteins
Sravnenie fiziko-khimicheskikh svoĭstv model'nykh immunnykh kompleksov iz normal'nykh i mielomnykh belkov.