[Modification of the interphase death of thymocytes by using colcemid].
The pretreatment of thymocytes by colcemid (0.02 to 0.5 mu g/ml) induces a change in the plasma membrane state, registered by a pyrene fluorescent probe, and a decrease in the interphase cell death after 4 Gy X-irradiation. The authors discuss the role of the cell surface as a trigger initiating death program in irradiated lymphoid cells.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003703:Demecolcine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007399:Interphase / Q000187:drug effects* / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051381:Rats; D013499:Surface Properties; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D003703:Demecolcine
Modifikatsiia interfaznoĭ gibeli timotsitov s pomoshch'iu koltsemida.