[Concentration of thiobarbituric acid reactive substances (TBARS) in serum following myocardial infarct].
The serum concentration of thiobarbituric acid reactive substances (TBARS), which can be used in the characterization of O2-radical metabolism, was analyzed in patients with myocardial infarction in the acute phase, 10-14 days, 1 month, and 6 months after infarction, and compared with the TBARS concentration of a healthy group and a group with atherosclerosis. After myocardial infarction we found increased TBARS concentration at all moments of investigation in comparison with the healthy and atherosclerosis groups. Maximum concentration was found 10-14 days after infarction, afterwards the TBARS concentration decreased, without however attaining the values which we found in the comparison groups. The increased TBARS concentration 6 months after myocardial infarction demonstrates a manifestation of disturbances in the O2-radical metabolism. Such disturbances may be regarded as a high-risk factor to the cardiovascular system.
D001161:Arteriosclerosis / Q000097:blood; D005500:Follow-Up Studies; D005609:Free Radicals; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010100:Oxygen / Q000097:blood*; D013858:Thiobarbiturates / Q000097:blood*
D005609:Free Radicals; D008054:Lipid Peroxides; D013858:Thiobarbiturates; C029684:thiobarbituric acid; D010100:Oxygen
Konzentration Thiobarbitursäure-reaktiver Substanzen (TBARS) im Serum nach Myokardinfarkt.