The C3-F gene in patients with intracranial saccular aneurysms.
The C3-F gene has previously been found associated with atherosclerotic vascular diseases. The occurrence of the C3-F gene was therefore investigated in a group of 110 hospitalized patients with intracranial saccular aneurysms. The C3-F gene occurred equally often in patients and controls. In patients with a ruptured aneurysm, however, the C3-F gene frequency was significantly increased in subjects aged 40-49 years followed by a marked and statistically significant decline with increasing age. The findings suggest that the C3-F gene may be a risk factor for early aneurysm rupture.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012306:Risk; D012737:Sex Factors; D013345:Subarachnoid Hemorrhage / Q000235:genetics
D003176:Complement C3