PD 124,895 and PD 124,966, two new antitumor antibiotics.
The isolation and characterization of the title antibiotics, which are produced by the same Streptomyces sp., is described. The potent antitumor agent, PD 124,895, is an analog of hydroxyelactocin (PD 114,721). PD 124,966 is a new member of the depsipeptide family of antibiotics.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D010456:Peptides, Cyclic; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D005231:Fatty Acids, Unsaturated; D010455:Peptides; D010456:Peptides, Cyclic; C051484:PD 124895; C051485:PD 124966