[Calcium transport in erythrocytes loaded with a highly selective Ca2+ chelator. The characteristics associated with primary hypertension].
The kinetics of 45Ca accumulation was studied in erythrocytes loaded with highly-selective Ca2+ chelator quin-2. Ca2+ erythrocyte penetration rate was increased by 20-30%, and free intracellular calcium (Ca2+ in), by 40-50%, in hypertensive patients, as compared to normotensive controls. Spontaneously hypertensive rats showed no differences in this respect. The addition of valinomycin and quinidine produced a tenfold increase in Ca2+ penetration rate in human erythrocytes and a 1.5-2-fold increase in rat erythrocytes. Under these conditions, the erythrocyte Ca2+ penetration rate and Ca2+ in concentration were increased by 40 and 60%, respectively, in spontaneously hypertensive rats. Hypertensive patients showed no differences. After incubation with the Ca-ATPase inhibitor orthovanadate, erythrocyte calcium level in the absence of quin-2 was 2-3 times as high in spontaneously hypertensive rats as it was in control animals.
D000328:Adult; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002614:Chelating Agents / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D051381:Rats; D011918:Rats, Inbred SHR
D002614:Chelating Agents; D002118:Calcium
Transport kal'tsiia v éritrotsitakh, nagruzhennykh vysokoselektivnym khelatorom Ca2+. Osobennosti, vyiavliaemye pri pervichnoĭ gipertenzii.