Prothrombin Perija: a new congenital dysprothrombinemia in an Indian family.
A Western Venezuelan indigenous Yukpa(Irapa) family with moderate bleeding and discrepancy in the prothrombin values by biological and immunological methods is described. The propositus presented biological activity of 2% by the methods in one-stage including Staphylocoagulase and Echis carinatus. Electrophoretic migration of the prothrombin in plasma was normal, while the serum only showed one precipitation arc instead of the three of normal serum. The propositus appeared to be homozygous for the abnormal prothrombin which we have denominated Prothrombin Perijá.
D000293:Adolescent; D006801:Humans; D007020:Hypoprothrombinemias / Q000235:genetics*; D007123:Immunoelectrophoresis, Two-Dimensional; D007199:Indians, South American; D008297:Male; D010314:Partial Thromboplastin Time; D010375:Pedigree; D011516:Prothrombin / Q000032:analysis*; D011517:Prothrombin Time; D014687:Venezuela
C051338:prothrombin Perija; D011516:Prothrombin