Effects of sauvagine on behavioural arousal of mice.
The effects of natural and synthetic sauvagine on locomotor activity and ECS-induced seizures were studied in DBA/2 mice. A dose-dependent activity depression was evident following the administration of both compounds. Moreover they exerted a protective effect against ECS-induced seizures. This effect was naloxone-reversible, suggesting the involvement of endogenous opioids. In both series of experiments natural sauvagine was more effective than the synthetic compound.
D029845:Amphibian Proteins; D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D036361:Peptide Hormones; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced
D029845:Amphibian Proteins; D036361:Peptide Hormones; D010455:Peptides; C025727:sauvagine