[Characteristic effect of local anesthetics on the phospholipid composition of mitochondria].
Effect of local anesthetics on phospholipid composition was studied in rat liver mitochondria incubated in hypotonic solution of sucrose. Administration of trimecaine hydrochloride caused active hydrolysis of cardiolipin (CL), while destruction of phosphatidyl choline (PC), phosphatidyl ethanolamine (PEA), lysophosphatidyl choline (LPC), lysophosphatidyl ethanolamine (LPE) and lysocardiolipin (LCL) was inhibited. In the mixture containing tetracaine hydrochloride hydrolysis of PEA, LPC and LCL was decreased; dibucaine hydrochloride caused hydrolysis of CL and LPC, whereas PC was not hydrolyzed. The data obtained suggest that local anesthetics, dissimilar in their physico-chemical properties, exhibited specific effect on phospholipid spectrum of mitochondrial membranes.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D000779:Anesthetics, Local; D008563:Membrane Lipids; D010743:Phospholipids; D010740:Phospholipases
Osobennosti vliianiia mestnykh anestetikov na fosfolipidnyĭ sostav mitokhondriĭ.