title: [Action of streptokinase on the hemostatic indices of rabbits with a toxic lesion of the liver due to carbon tetrachloride].
abstract: The rabbits with CCl4-induced hepatic failure have revealed changes in hemostasis responses to streptokinase administration. The main distinction of hepatic dystrophy was the depression of plasma fibrinolytic activity accompanying the decrease in fibrinogen and antiplasmin concentrations. Streptokinase administration to rabbits with productive inflammatory liver disorders produced changes in hemostasis identical to those observed in intact rabbits, fibrinogen levels, however, remained unchanged. The common feature of all the toxic liver disorders is the increase of antithrombin III levels after streptokinase administration, whereas the antithrombin levels in the control animals were decreased.
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D013300:Streptokinase / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D013300:Streptokinase
vernacular_title: Deĭstvie streptokinazy na pokazateli gemostaza u krolikov pri toksicheskom porazhenii pecheni chetyrekhkhloristym uglerodom.