[Role of the structuro-functional disorganization of cell membranes in the pathogenesis of strokes].
The authors determined the levels of lipoperoxides and activities of endogenic phospholipases in red cell membranes and cerebrospinal fluid in 101 patients with ischemic and 35 patients with hemorrhagic strokes. The authors established increases in the activities of endogenic phospholipases and of processes of peroxidation of membrane lipids which correlated with the severity and outcome of cerebral strokes. It has been proved that the parameters of activity of membrane destructive processes may serve as criteria characterizing the severity and predicting the outcome of acute cerebral circulation impairments.
D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010740:Phospholipases / Q000378:metabolism*; D011379:Prognosis
D008054:Lipid Peroxides; D010740:Phospholipases
Rol' strukturno-funktsional'noĭ dezorganizatsii kletochnykh membran v patogeneze mozgvoykh insul'tov.