title: Subtotal resection of the head of the pancreas combined with ductal obliteration of the distal pancreas in chronic pancreatitis.
abstract: Subtotal resection of the head of the pancreas combined with duct obliteration of the distal pancreas by prolamine was performed in 12 selected patients who had chronic alcohol-induced pancreatitis with most destruction in the proximal pancreas. The main indication for operation was intractable pain. There was no postoperative mortality but morbidity was high when no pancreaticojejunostomy was constructed. After a follow-up period of 32 months, lasting pain relief was obtained in 10 patients; pseudocyst formation occurred in three patients; calcification of the distal pancreas, absent before operation, was demonstrated in four of six patients; six of 11 nondiabetic patients became hyperglycemic either abruptly (1 patient) or progressively (5 patients); quality of life improved in most patients. This procedure preserves the stomach, duodenum, spleen, distal pancreas and common bile duct if possible. However, pancreatic ductal obliteration with prolamine does not prevent relapses of chronic pancreatitis.
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000209:etiology; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D010183:Pancreatic Ducts; D010192:Pancreatic Pseudocyst / Q000209:etiology; D010195:Pancreatitis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011409:Propylene Glycols; D011506:Proteins / Q000627:therapeutic use*; D011788:Quality of Life; D015028:Zein
chemical_list: D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution