Hypothesis testing for proportions with overdispersion.
The properties of likelihood ratio tests and simpler t-tests are investigated by simulation under an assumed beta-binomial model for parameter values typically found in toxicological studies. It is found that likelihood ratio methods are at least as powerful as the simpler approaches and in certain situations can be significantly more powerful.
D000704:Analysis of Variance; D000818:Animals; D001699:Biometry / Q000379:methods; D008962:Models, Theoretical; D012107:Research Design; D014116:Toxicology