[Functional morphology of interstitial cells of the renal medulla after treatment with indomethacin and unilateral nephrectomy].
The ultrastructure of the renal medullary interstitial cells was compared with the quantitative estimation of the interstitial space and its proteoglycan content after stimulation (left nephrectomy) and inhibition (indomethacin administration) of the prostaglandin synthesis. Lysosomes were found to play a functional role in the lipid granule depletion and arachidonic acid release. The ratio of lysosomes to lipid granules within the interstitial cells may serve as a criterion of their functional activity in the process of prostaglandin synthesis. Functional state of the rough endoplasmic reticulum of the interstitial cells was indicative of the cells involvement in the production of the mediate intercellular substance.
D000818:Animals; D007213:Indomethacin / Q000494:pharmacology*; D007679:Kidney Medulla / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure*; D050356:Lipid Metabolism; D008297:Male; D008854:Microscopy, Electron; D009392:Nephrectomy; D009940:Organoids / Q000648:ultrastructure; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats
D011453:Prostaglandins; D007213:Indomethacin
Funksional'naia morfologiia interstitsial'nykh kletok mozgovogo veshchestva pochek pri vozdeĭstvii indometatsina i odnostoronneĭ nefréktomii.