Metabolism of free fatty acids (FA) and triacylglycerol (TG) in acute and subacute fluoride intoxication of the rat.
In rats acute intoxication with 100 mg sodium fluoride/kg body wt. orally has the following metabolic consequences. Oxygen consumption is reduced by about 30-50%. Plasma free FA decrease in fed as well as in starved rats. Hepatic FA synthesis is enhanced, but TG secretion to the blood is not altered. Intravenously injected Intralipid 20% is removed at a normal rate. In subacute intoxication (30 mg sodium fluoride/kg body wt given orally per day over 1 week) oxygen consumption is not affected. TG secretion and removal of Intralipid remain in the normal range whereas hepatic FA synthesis is increased as in acute intoxication. TG concentration in the liver, however, increases by about 30% after 1 week.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D012969:Sodium Fluoride