title: Self-organization of ependyma in regenerating teleost spinal cord: evidence from serial section reconstructions.
abstract: Multiple ependymal structures have been observed in regenerating spinal cord of the teleost Apteronotus albifrons. Evidence is presented for two modes of formation of the secondary ependymas: budding off from the primary ependyma, and de novo origin of a tube-like ependymal structure within a group of undifferentiated cells. Serial sections of regenerated cord provide evidence that undifferentiated cells not in immediate contact with the main ependymal layer can organize and differentiate into an ependymal structure in the regenerating spinal cord. These findings suggest that a significant amount of morphological organization can take place independent of the normal developmental sequence and environment.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D004805:Ependyma / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure; D005399:Fishes; D008854:Microscopy, Electron; D012038:Regeneration; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*