Age-related changes in anti-elastin antibodies in serum from normal and atherosclerotic subjects.
A modified version of the enzyme-linked immunosorbent assay (ELISA), utilising human insoluble aortic elastin, was used for determination of anti-elastin antibodies in serum from normal and atherosclerotic subjects. The age-related changes in their level among healthy persons were investigated. Anti-elastin antibodies were found in all the tested human sera, showing the highest level at the age of 18-20 and the lowest at the age over 60 and especially among atherosclerotic patients. The possible role of the immune system in the turnover of elastin is discussed.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001161:Arteriosclerosis / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004549:Elastin / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D004549:Elastin