[Functional state of the sympatho-adrenal system at late stages of the tumor process after cyclophosphamide and 5-fluorouracil administration].
The effect of cyclophosphamide and 5-fluorouracil on the neurochemical determinants of the functional state of the sympatho-adrenal system (SAS) is studied in C57BL mice with metastatic Lewis carcinoma and tumours induced by subcutaneous administration of 20-methylcholanthrene. It is established that pathologic effect of cytostatics on the SAS is especially pronounced at the late stages of the tumour process. In this case urine excretion of DOPA, catecholamines and their catabolites is observed.
D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D013997:Time Factors
D003520:Cyclophosphamide; D005472:Fluorouracil
Funktsional'noe sostoianie simpatoadrenalovoĭ sistemy na pozdnikh stadiiakh opukholevogo protsessa pri vvedenii tsiklofosfana i 5-ftoruratsila.