title: Modulation of polycation-induced redistribution of melanoma cell surface anionic macromolecules by retinoic acid.
abstract: The ability of cationized ferritin (CF) to redistribute negatively charged cell surface molecules has been shown to increase after malignant transformation. Pretreatment of murine melanoma S91-C2 and B16-F1 cells with retinoic acid (RA), which suppresses their transformed phenotype, decreased the ability of CF to cluster surface anionic sites. In contrast, a similar pretreatment of RA-resistant mutant clone S91-C154 and subline B16-F10 caused only a minor reduction in CF-induced patching of anionic sites. These results indicate that the effect of RA on the redistribution of negatively charged cell surface molecules is related to the growth-inhibitory action of this vitamin A metabolite.
mesh_terms: D000818:Animals; D002460:Cell Line; D005293:Ferritins / Q000494:pharmacology*; D008545:Melanoma / Q000378:metabolism*; D012795:Sialoglycoproteins / Q000032:analysis; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D012795:Sialoglycoproteins; C010297:polycationic ferritin; D014212:Tretinoin; D005293:Ferritins