Effect of protein binding on steady-state equations.
Previously published steady-state equations assumed elimination of total drug. The equations have been derived to cover the case where only free (unbound) drug is eliminated. The equation for oral administration is the same in both cases. The equation for intravenous administration has the same form, but the interpretation of Km is different.
D000284:Administration, Oral; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D011485:Protein Binding
D004364:Pharmaceutical Preparations