[The microenvironment of tumor cells and the antitumor effect of hyperthermia].
Intravenous infusion of 20% solution of glucose (80 mg/kg of body mass per 1 min) resulted in considerable changes in microenvironment of tumor cells: by the 90th-120th min of infusion there was a decrease in pH, pO2, blood flow inhibition, an increase in the relative number of cells in the S-phase of the mitotic cycle in a tumor. There was no increase in tumor ATP and glucose up to the values at which these substance could enhance thermoresistance, a situation being rather favorable for realizing a damaging effect of hyperthermia. The use of hyperglycemia in the above regimen prior to MWF-hyperthermia enhanced 2-3 times its antitumor effect on the model of subcutaneously transplanted Guéren carcinoma and Pliss lymphosarcoma. Glucose at the concentration of 5-0 mmol enhanced the thermosensitivity of L-1210 cells. The results indicated the efficacy of hyperglycemia combined with hyperthermia.
D000818:Animals; D003131:Combined Modality Therapy; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000378:metabolism; D006979:Hyperthermia, Induced; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism / Q000532:radiotherapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000532:radiotherapy*; D051381:Rats
D005947:Glucose
Mikrookruzhenie opukholevykh kletok i protivoopukholevyĭ éffekt gipertermii.