Adhesion formation to the uterine horn of the rat in response to nylon and a new absorbable clip.
We have evaluated the tissue reactivity as manifested by adhesion formation to the uterine horn of the rat in response to a new absorbable surgical clip. A standard lesion on the uterine horn was created and repaired with either nylon sutures or an absorbable clip. Adhesion formation to the operative site was evaluated using a point based grading system, seven, 21 and 120 days postoperatively. A statistically significant increase in adhesion formation and their severity was seen on the uterine horns repaired with the surgical clips. The adhesions did not improve with time. In two instances, abscesses were formed around the clips. The use of the surgical clips in the peritoneal cavity needs to be investigated further. Their use in women in the reproductive age group who wish to preserve their reproductive potential is discouraged.
D000818:Animals; D005260:Female; D009757:Nylons / Q000009:adverse effects*; D011108:Polymers / Q000009:adverse effects*; D051381:Rats; D013528:Surgical Staplers; D013537:Sutures; D000267:Tissue Adhesions; D014591:Uterine Diseases / Q000209:etiology*
D009757:Nylons; D011108:Polymers; C048851:polysorb