[Repeated irradiation of recurrent head and neck tumors using hyperthermia].
The authors presented an analysis of immediate and short-term results of therapy of 115 patients on thermoradio- and chemotherapy for recurrent head and neck tumors. Triple irradiation at single focal doses of 10 Gy at one-week intervals between fractions were employed taking into account radioresistance of recurrent tumors. After each session of irradiation the patients received polychemotherapy (cyclophosphamide, vinblastine, methotrexate) for 2 days. Local MWF-hyperthermia was provided before a session of irradiation and during drug administration. Complete or partial tumor regression was noted in 94% of the patients with the resultant improvement in their general status. The 3-year disease-free interval was noted in 41% of the patients. Radiation changes were restricted to atrophy of the skin and mucous membranes and stable disorders of salivation.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D003520:Cyclophosphamide / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D003520:Cyclophosphamide; D008727:Methotrexate
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