[Experimental filariasis in Proechimys oris by Dipetalonema dessetae. 5. Effect of parasitism on metabolism of diethylcarbamazine].
The metabolism of diethylcarbamazine (DEC) in healthy and filaria-infected Proechimys oris Rodents was investigated. DEC and 14C labelled DEC were orally administrated (100 mg/kg). The drug was quickly and intensively metabolised. About 90% of the dose administered was eliminated in the urine within 24 hours. Monodeethylation was the major pathway. The major urinary metabolites were ethylcarbamazine and its N-oxide. Traces of N methylpiperazine 2,5 dione and their N-oxide were also found. Elimination was faster in filarial than in healthy animals, but metabolites were the same.
D000818:Animals; D004049:Diethylcarbamazine / Q000378:metabolism*; D004154:Dipetalonema Infections / Q000378:metabolism*; D005368:Filariasis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D012377:Rodentia / Q000378:metabolism* / Q000469:parasitology
D004049:Diethylcarbamazine
Filariose expérimentale du Proechimys oris par Dipetalonema dessetae: 5. Effet du parasitisme sur le métabolisme de la diéthylcarbamazine.