Cell attachment and chemotaxis can utilize the same peptide sequence of fibronectin.
Fibronectin and fragments of the parent molecule are involved in cell-substrate attachment, cell migration and chemotaxis. The cell attachment sequence, Gly-Arg-Gly-Asp-Ser-Pro, was synthesized and tested for its ability to effect ligamentum nuchae fibroblast chemotaxis. This hexapeptide and fibronectin itself both caused directed cell migration, with maximal activity in the 10(-10) to 10(-9) M range. These data demonstrate that the fibronectin cell binding site and chemotaxis site share a common sequence.
D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D002478:Cells, Cultured; D002633:Chemotaxis; D005353:Fibronectins / Q000502:physiology*; D008022:Ligaments / Q000166:cytology; D009842:Oligopeptides / Q000494:pharmacology; D013329:Structure-Activity Relationship
D005353:Fibronectins; D009842:Oligopeptides