Release of cerebellar inhibitory activity by partial destruction of the inferior olive with kainic acid in rat.
Partial destruction of the neurones of the inferior olive was obtained by local ionophoretic injection of kainic acid. Complex spike discharges of the Purkinje cells are suppressed 2-3 h after application of the drug. The metabolic activity increases in the region of the cerebellar nuclei within 2 h and persists for 3 days following the kainic acid injection. The increase is only observed in those parts of the cerebellar nuclei receiving terminals from the Purkinje cells deafferented of the climbing fibres. No changes were detected when the injection affected only the underlying reticular formation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001345:Autoradiography; D002531:Cerebellum / Q000502:physiology*; D003847:Deoxyglucose / Q000378:metabolism; D007478:Iontophoresis; D007608:Kainic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009433:Neural Inhibition; D009847:Olivary Nucleus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D003847:Deoxyglucose; D007608:Kainic Acid