[Biosynthesis of corticosteroid hormones in the cortical areas of the rat adrenal during emotional stress combined with a salt load].
The experiments on male albino rats have shown that excessive salt uptake increases the functional sensitivity of the adrenal cortex to emotional stress (group fighting). Emotional stress in combination with a salt load induces a much greater increment in corticosterone and 18-oxy-11-deoxycorticosterone production by fascicular and glomerular adrenal zones through the activation of the pregnenolone pathway of hormonal biosynthesis. A relatively high aldosterone production was also retained. Thus, the total mineralocorticoid potential directed to sodium retention in the body is in these conditions inadequately increased.
D000302:Adrenal Cortex / Q000187:drug effects / Q000503:physiopathology*; D000305:Adrenal Cortex Hormones / Q000032:analysis / Q000096:biosynthesis*; D000818:Animals; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology*
D000305:Adrenal Cortex Hormones; D012965:Sodium Chloride
Biosintez kortikosteroidnykh gormonov v zonakh kory nadpochechnikov krys pri émotsional'nom stresse v sochetanii s solevoĭ nagruzkoĭ.