title: Anterior hypothalamic lesions decrease anaphylactic contractions in guinea pig trachea in vitro by reducing histamine and LTC4 reactivity.
abstract: Discrete lesions in the anterior hypothalamus (AHA) of the guinea pig brain reduce the anaphylactic contraction of the trachea in vitro after active in vivo sensitization by 40%. This difference in anaphylactic contraction does not correlate with a difference in homocytotropic antibodies but coincides with a decreased smooth muscle response to the anaphylactic mediators histamine and leukotriene C4. No difference in the beta-adrenoceptor function of the tracheal preparations can be found. The results suggest that AHA lesions afford protection against anaphylaxis in actively sensitized guinea pigs at least in part through a reduced smooth muscle response to anaphylactic mediators.
mesh_terms: D000707:Anaphylaxis / Q000209:etiology* / Q000517:prevention & control; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007032:Hypothalamus, Anterior / Q000502:physiology*; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000276:immunology* / Q000502:physiology
chemical_list: D007136:Immunoglobulins; D013189:SRS-A; D006632:Histamine