Phagocytosis of yeast cells by monocytes: effects of fluorouracil, doxorubicin and mitomycin.
The drugs in the FAM combination (fluorouracil, doxorubicin, mitomycin) were tested for a possible effect on monocyte function by means of a glass-surface fluorescence-quenching technique of monocyte phagocytosis. The individual drugs significantly inhibited monocyte phagocytosis. The inhibition was located at the engulfment phase of phagocytosis and in an order of magnitude of 20-30%. The FAM combination did not suppress monocyte phagocytosis more than each one of the individual drugs. It is suggested that a slight inhibition of monocyte phagocytosis is a cost of cytotoxic treatment.
D002448:Cell Adhesion / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D008937:Mitomycins / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D015003:Yeasts / Q000276:immunology
D008937:Mitomycins; D004317:Doxorubicin; D005472:Fluorouracil