[Specific protein in the plasma of rheumatoid arthritis patients].
A unique protein was detected in the plasma of rheumatoid arthritis patients by two-dimensional electrophoresis. We named it rheumatoid arthritis specific protein (RASP). According to the pattern and concentration of its spot, RA patients were classified into three groups as RASP+, RASP +/- and RASP-. RASP+ was detected only in RA and its occurrence was 45/120 (38%). The occurrence of RASP including RASP +/- was 84/120 (70%) in RA, 6/13 (46%) in SLE, 2/8 (25%) in PSS, 11/51 (22%) in liver disease and 4/44 (9%) in normal. RA patients with RASP+ indicated significantly high level of ESR, CRP and platelet counts comparing with RA patients with RASP-. These results suggested that RASP might be a good indicator for the diagnosis and evaluation of the activity of RA. RASP was purified with gel chromatography repeated three times. RASP was very similar with immunoglobulin G in its biochemical and immunological properties.
D000209:Acute-Phase Proteins; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis*; D001798:Blood Proteins / Q000032:analysis* / Q000302:isolation & purification; D002648:Child; D004586:Electrophoresis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012737:Sex Factors
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D007136:Immunoglobulins; C048262:rheumatoid arthritis specific protein, human