Angiotensin II inhibits the K+-evoked release of [3H]norepinephrine from hypothalamic synaptosomes of the spontaneously hypertensive rat.
The effect of angiotensin II on the basal and K+-evoked release of [3H]norepinephrine was examined in hypothalamic and brainstem synaptosomes from adult male normotensive (Wistar-Kyoto, WKY, and Sprague-Dawley, SD), and spontaneously hypertensive (SH) rats. Angiotensin II attenuated the [3H]norepinephrine release caused by maximal depolarizing concentrations of K+ (75 mM) in hypothalamic synaptosomes of the SH rat, but had no effect on basal [3H]norepinephrine release. Angiotensin II had no effect on either the basal or K+-evoked release of [3H]norepinephrine in brain synaptosomes prepared from either WKY or SD adult male rats. The results suggest a distinct role of angiotensin II in the modulation of catecholamine release in the SH rat.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D000804:Angiotensin II; D011188:Potassium; D009638:Norepinephrine