Squamous cell carcinoma of the neovagina.
Congenital absence of the vagina is very rare, with one method of treatment being the split-thickness skin graft vaginoplasty. This is the ninth reported instance of carcinoma arising in the neovagina and is apparently related to the type of tissue transplanted. The optimal therapy for this malignancy remains to be defined. A review of previously reported patients plus this patient suggests that reliance on radiotherapy as the primary means of treatment may result in a high percentage of failures.
D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications / Q000209:etiology* / Q000532:radiotherapy; D013997:Time Factors; D014621:Vagina / Q000002:abnormalities* / Q000601:surgery; D014625:Vaginal Neoplasms / Q000209:etiology* / Q000532:radiotherapy