Influence of a single neonatal melatonin treatment on the basal and thyrotropin or melatonin modified blood thyroxine level of adult rats.
Neonatal melatonin treatment caused a significant increase in thyroxine (T4) level at one month of age. Preexposure to melatonin in neonatal age and reexposure after one month accounted for a still greater increase in T4 production. Rats neonatally exposed to melatonin did not respond to TSH at one month of age.
D000818:Animals; D000831:Animals, Newborn; D008550:Melatonin / Q000494:pharmacology*; D051381:Rats; D013972:Thyrotropin / Q000494:pharmacology; D013974:Thyroxine / Q000097:blood*
D013972:Thyrotropin; D008550:Melatonin; D013974:Thyroxine