title: Thrombin infusion to control bleeding during vitrectomy for stage V retinopathy of prematurity.
abstract: We prospectively studied 36 consecutive premature infants with the diagnosis of retinopathy of prematurity stage V with total traction retinal detachment who underwent lensectomy/vitrectomy and epiretinal membrane delamination. The first 26 patients underwent vitrectomy using thrombin mixed with Balanced Salt Solution Plus at a concentration of 100 U/mL and the remaining ten patients had pure Balanced Salt Solution Plus used. Intraoperative and postoperative bleeding were monitored. The overall intraoperative bleeding rate was 92% (33/36). Intraoperative bleeding (19% vs 80%) and bleeding at the time of wound closure (4% vs 30%) were both significantly reduced in the thrombin vs no thrombin group.
mesh_terms: D005123:Eye; D005128:Eye Diseases / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007267:Injections; D007432:Intraoperative Period; D008297:Male; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000601:surgery*; D013917:Thrombin / Q000627:therapeutic use*; D014821:Vitrectomy / Q000009:adverse effects*
chemical_list: D013917:Thrombin