Serum and bone concentrations of cefuroxime in patients undergoing knee arthroplasty.
Concentrations of cefuroxime were measured in the serum and femoral and tibial bone of 12 patients undergoing knee arthroplasty, following cefuroxime 1.5 g iv. The mean serum cefuroxime concentration was 112.4 mg/l at the time of application of the mid thigh tourniquet. The mean femoral bone concentration was 18.6 mg/kg and tibial bone was 15.5 mg/kg. These concentrations of cefuroxime appear adequate for prophylaxis against post-operative infection in knee arthroplasty.
D001178:Arthroplasty; D002444:Cefuroxime / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D002511:Cephalosporins / Q000032:analysis*; D005260:Female; D005269:Femur / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D011292:Premedication; D013977:Tibia / Q000032:analysis*
D002511:Cephalosporins; D002444:Cefuroxime