Pharmacological properties of 3-aminoalkyl and amide derivatives of 5,5-diphenylhydantoin.
5,5-Diphenylhydantoin derivatives containing at the position 3 aminoalkyl (1, 2, 4, 5), aminohydroxyalkyl (3) and amide (6, 8) groups were synthesized. The compounds, given in a dose of 50 mg/kg, did not affect cardiac bioelectric activity and, in contrast to diphenylhydantoin, did not possess the antiarrhythmic properties and did not protect against pentetrazol seizures.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004562:Electrocardiography; D008297:Male; D051379:Mice; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D010672:Phenytoin