title: Basically substituted ellipticine analogues as potential antitumor agents.
abstract: Installation of a basic side chain on the ring nitrogen of ellipticine did, as expected, improve the DNA binding properties of these molecules as measured by an ethidium displacement assay. In vivo antitumor activity was not, however, improved.
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004611:Ellipticines / Q000138:chemical synthesis* / Q000627:therapeutic use; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D004611:Ellipticines; D007202:Indicators and Reagents