Effect of dermal application of phosphamidon-92 (technical) on different tissues and hematobiochemical parameters in albino rat.
The histological disturbances occurring from the dermal application of low, medium, and high doses of phosphamidon-92 (technical) to rats as observed by light microscope and analysis of hematobiochemical parameters of blood are presented. Groups of 10 male and 10 female albino rats (Wistar strain) were treated with the test material at dose levels of 0.48 (low), 2.2 (medium), and 3.98 (high) mg/kg X d for 3 wk, followed by a 2-wk observation period. During application, a reduction in food intake and in body weight was recorded with all three treatments. However, gain in body weight and food intake resumed during the observation period and was marked with the high-dose treatment only. Symptoms like hypersalivation and frothing were noticed in both the sexes, as well as a relative decrease in liver weight and gross pathological alterations on microscopical examination of skin, lung, kidney, and testis; significant alterations in some hematobiochemical parameters of blood were observed.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010707:Phosphamidon / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D006454:Hemoglobins; D007306:Insecticides; D010707:Phosphamidon; D000109:Acetylcholine