title: Comparison of self-hypnosis and propranolol in the treatment of juvenile classic migraine.
abstract: In a prospective study we compared propranolol, placebo, and self-hypnosis in the treatment of juvenile classic migraine. Children aged 6 to 12 years with classic migraine who had no previous specific treatment were randomized into propranolol (at 3 mg/kg/d) or placebo groups for a 3-month period and then crossed over for 3 months. After this 6-month period, each child was taught self-hypnosis and used it for 3 months. Twenty-eight patients completed the entire study. The mean number of headaches per child for 3 months during the placebo period was 13.3 compared with 14.9 during the propranolol period and 5.8 during the self-hypnosis period. Statistical analysis showed a significant association between decrease in headache frequency and self-hypnosis training (P = .045). There was no significant change in subjective or objective measures of headache severity with either therapy.
mesh_terms: D000704:Analysis of Variance; D002648:Child; D005260:Female; D006801:Humans; D006990:Hypnosis / Q000379:methods*; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000628:therapy*; D011433:Propranolol / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation
chemical_list: D011433:Propranolol