Carcinoid tumor arising in a treated primary germ cell tumor of the mediastinum.
A 33-year-old man had a locally aggressive anterior mediastinal carcinoid tumor, manifested as an enlarging mass refractory to chemotherapy two years after initially successful treatment of a primary germ cell tumor. Ultrastructurally, the tumor contained dense-core endocrine-type secretory granules. Many mediastinal carcinoid tumors have been reported, but we found no examples of such a tumor arising as a sequel to or as a refractory component of a mediastinal germ cell tumor after initially effective therapy.
D000328:Adult; D002276:Carcinoid Tumor / Q000473:pathology*; D004407:Dysgerminoma / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology*