[Anti-arrhythmic effect of ryanodine in the guinea pig with glycoside poisoning].
The effect of ryanodine on membrane potential oscillations in vitro (in isolated guinea-pig papillary muscle) and on ventricular arrhythmias in vivo (in glycoside intoxication) were studied. 3-5 minutes after ryanodine (0.5 microM) addition the membrane potential oscillations induced by ouabain (1 microM) were abolished. 4-5 minutes after intravenous ryanodine infusion (15 micrograms/kg) ventricular arrhythmias induced by ouabain intoxication (75-115 micrograms/kg) disappeared and 8-10 minutes later sinus rhythm was restored. It is suggested that antiarrhythmic effect of ryanodine is a result of the inhibition of diastolic membrane potential oscillations.
D000200:Action Potentials / Q000187:drug effects; D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009129:Muscle Tonus / Q000187:drug effects; D010042:Ouabain / Q000506:poisoning*; D010210:Papillary Muscles / Q000187:drug effects; D012433:Ryanodine / Q000494:pharmacology / Q000627:therapeutic use*
D000470:Alkaloids; D000889:Anti-Arrhythmia Agents; D012433:Ryanodine; D010042:Ouabain
Antiaritmicheskiĭ éffekt rianodina u morskoĭ svinki pri glikozidnoĭ intoksikatsii.