[Cleavage of 2-phenylpropan-1-ol and 2-phenylpropan-2-ol-glucuronide, 2 metabolites of isopropylbenzol (Cumol)].
The behaviour of 2-phenyl-1-propanol (I) and 2-phenyl-2-propanol (II) and their glucuronides with HCl has been investigated. While I shows a high acidic constancy, II undergoes a partial conversion into 2-phenylpropane (III) which itself yields numerous products. The glucosidic bond of glucuronide I is quantitatively split by 10.0% HCl, whereby an aglucone yield of nearly 100% is obtained. The second glucuronide behaves otherwise: the recovery of II is very low (only 40% to 45%) with HCl concentrations of 1.0%-20.0%, although with 1.0% HCl 100% of the glucuronide is hydrolysed.
D000433:1-Propanol / Q000378:metabolism; D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005965:Glucuronates / Q000378:metabolism*; D006197:Hair / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D051379:Mice; D020005:Propanols
D001555:Benzene Derivatives; D005965:Glucuronates; D020005:Propanols; C051276:2-phenyl-2-propyl glucuronide; C017622:2-phenylpropanol-1; C017623:2-phenyl-2-propanol; C051275:2-phenyl-1-propyl glucuronide; C015763:cumene; D000433:1-Propanol
Spaltung von 2-Phenylpropan-1-ol-und 2-Phenylpropan-2-ol-Glucuronid, zweier Metaboliten des Isopropylbenzol (Cumol).