Prediction of response to nortriptyline and phenelzine by platelet MAO activity.
Thirty-seven depressed patients over the age of 55 were treated for 5-7 weeks with either nortriptyline, a tricyclic antidepressant, or phenelzine, a monoamine oxidase (MAO) inhibitor. Patients' platelet MAO activity was measured following a drug washout period before treatment. Patients with higher MAO activity had a better response to treatment, regardless of which drug was used.
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D009661:Nortriptyline / Q000494:pharmacology / Q000627:therapeutic use*; D010624:Phenelzine / Q000494:pharmacology / Q000627:therapeutic use*; D011336:Probability; D011569:Psychiatric Status Rating Scales
D009661:Nortriptyline; D008995:Monoamine Oxidase; D010624:Phenelzine