[Neonatal administration of 5,7-dihydroxytryptamine induces in the adult rat a decrease in paradoxical sleep restored by an intracisternal injection of fetal raphe cells].
By a method of automatic on-line scoring of sleep-waking stages in the rat, a significant decrease of the mean circadian level of paradoxical sleep and a significant increase of light slow sleep were shown in adult animals after neonatal disruption of serotoninergic system by intracisternal injection of 100 micrograms of 5.7-dihydroxytryptamine, when compared to an aged matched sham group. The level of paradoxical sleep was restored in the neurotoxin-treated rats by an intracisternal injection of a suspension of foetal raphe neurons.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D005333:Fetus; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology* / Q000637:transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin
L'administration néonatale de 5,7-dihydroxytryptamine induit chez le rat adulte une chute du sommeil paradoxal, qui est restauré par l'injection intracisternale de cellules raphéennes foetales.