The effect of Mucodyne on nasal clearance in healthy adults.
A randomized double-blind cross-over trial in healthy young adults compared the effect of S-carboxymethylcysteine (2.25 g per day for 7 days) against placebo on nasal mucociliary clearance. The clearance rate of a radio-labelled aqueous test spray was measured by gamma scintigraphy. Analysis of the data revealed no significant effect of the drug compared to placebo.
D000281:Administration, Intranasal; D000328:Adult; D001692:Biological Transport; D002233:Carbocysteine / Q000627:therapeutic use*; D002923:Cilia / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009093:Mucus / Q000378:metabolism; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D013668:Technetium Tc 99m Aggregated Albumin
D013668:Technetium Tc 99m Aggregated Albumin; D002233:Carbocysteine; D003545:Cysteine