title: Diurnal variation of intraocular pressure and the overriding effects of sleep.
abstract: Intraocular pressure (IOP) was recorded regularly over a 24-h period in 13 normal subjects. All subjects showed a dramatic rise in IOP after sleep, ranging from 37 to 248%. In a second experiment, IOP decreased when 15 subjects remained upright and awake throughout the night. When sleep was not permitted IOP was lowest at 3:00 a.m. (0300); when six of these subjects were permitted to sleep from 0600 to 0800, they showed a rapid and significant increase in IOP of up to 150%, whereas the remaining nine subjects showed (posturally induced) increases of up to 38%.
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008550:Melatonin / Q000097:blood; D011187:Posture; D012890:Sleep; D014065:Tonometry, Ocular; D014851:Wakefulness
chemical_list: D008550:Melatonin