[Effect of complexes of heparin with plasma proteins on the anticoagulant and fibrinolytic activity of blood].
Mixture of heparin complexes with plasma proteins of the rat blood with no fibrinogen, prothrombin or factors of prothrombin complex obtained either in presence or absence of CaCl2, revealed strong anticoagulating, fibrinolytic, antiaggregating and antipolymerizational activities. 1--2 mM CaCl2 solution increased the enzymatic and non-enzymatic activities of the mixture in vitro. The i.v. administration of the mixture to albino rats potentiated the anticoagulating and fibrinolytic activities of the blood plasma.
D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D001798:Blood Proteins / Q000494:pharmacology*; D002122:Calcium Chloride / Q000008:administration & dosage; D055598:Chemical Phenomena; D002621:Chemistry; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
D001798:Blood Proteins; D000990:Antithrombin III; D006493:Heparin; D002122:Calcium Chloride
Vliianie kompleksov geparina s belkami plazmy n antikoaguliantnuiu i fibrinoliticheskuiu aktivnost' krovi.