title: Spinal cord compression in Paget's disease of bone with reference to sarcomatous degeneration and calcitonin treatment.
abstract: Four cases of spinal cord compression stemming from Paget's disease of bone tissue are reported. Sarcomatous degeneration was proved in one case and in another one malignancy was deduced by computed tomography (CT) scanning. Clinical and radiologic manifestations as well as surgical management are discussed. The value of CT scanning of the spine as an aid in the evaluation of structural changes and the size of the soft tissue mass in sarcomatous degeneration of the lesion is stressed. After calcitonin administration, alleviation of pain and improvement in neurological status have occurred in two treated patients.
mesh_terms: D000368:Aged; D002116:Calcitonin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D012509:Sarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013117:Spinal Cord Compression / Q000150:complications* / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D002116:Calcitonin