Triiodothyronine decreases the production of androgen binding protein by rat Sertoli cells.
Triiodothyronine (T3) effects on cultured Sertoli cells from immature rats were investigated by evaluating the production of androgen binding protein (ABP) a biochemical marker of Sertoli cell function. The results demonstrate that T3 administration to the rat as well as T3 addition to the culture medium specifically decreases ABP production by Sertoli cells, suggesting a direct regulatory role of thyroid hormone on male reproductive function.
D000727:Androgen-Binding Protein / Q000096:biosynthesis*; D000818:Animals; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D007700:Kinetics; D007773:Lactates / Q000378:metabolism; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000187:drug effects / Q000378:metabolism*; D014284:Triiodothyronine / Q000494:pharmacology*; D014633:Valine / Q000378:metabolism
D000727:Androgen-Binding Protein; D002250:Carbon Radioisotopes; D007773:Lactates; D011506:Proteins; D014284:Triiodothyronine; D014633:Valine