Comparison of glucose transport mechanisms at opposing surfaces of the renal proximal tubular cell.
This review contrasts the glucose transport mechanisms at opposing surfaces of the renal proximal convoluted tubule: the Na+-dependent D-glucose transporter localized at the brush border membrane and the Na+-independent transporter localized at the basolateral surface. The two sugar transport mechanisms are discussed from the point of view of their specificity, kinetic, and regulatory behaviors. Recent results focussing on molecular characterization of these different carrier proteins are also described, including some newer information on purification of the Na+-dependent glucose carrier from the brush border membrane.
D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000033:anatomy & histology / Q000378:metabolism*; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D010695:Phlorhizin / Q000378:metabolism
D009004:Monosaccharide Transport Proteins; D010695:Phlorhizin