Bypass induced liver disease: an experimental study of the effect of post-operative protein supplementation and metronidazole therapy in an animal model.
An animal model of jejuno-ileal bypass (JIB) with post-operative weight loss and liver dysfunction was established in the rat. The role of a protein supplemented diet and post-operative metronidazole was investigated using this model. The use of a protein supplemented diet alone markedly reduced the detrimental effects of JIB. Although a beneficial effect was also noted with post-operative metronidazole, it was less marked and there appeared to be no additive benefit when both were used together. The results of this study would support the routine use of a protein enriched diet post-operatively in patients undergoing JIB.
D000818:Animals; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008111:Liver Function Tests; D008795:Metronidazole / Q000627:therapeutic use*; D008954:Models, Biological; D010865:Pilot Projects; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains
D004044:Dietary Proteins; D008795:Metronidazole