Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis.
A 2-to 16-fold increase in the number of glucocorticoid receptors of circulating lymphocytes was observed in 17 septic patients as compared to 10 control patients with no inflammatory disease. The number of receptors was low in 3 septic patients who did not respond to antibiotic and glucocorticoid therapy and died. Intravenous administration of 100 mg of cortisol reduced the number of receptors available to the assay by about 30% in both septic and control patients.
D000328:Adult; D000368:Aged; D001665:Binding Sites; D005260:Female; D005734:Gangrene / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D007958:Leukocyte Count; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000097:blood* / Q000188:drug therapy; D011965:Receptors, Glucocorticoid / Q000097:blood* / Q000187:drug effects / Q000502:physiology
D011965:Receptors, Glucocorticoid; D006854:Hydrocortisone