title: Effect of salinomycin supplementation on characteristics of digestion and feedlot performance of cattle.
abstract: One hundred fifty large-frame British-cross calves, 75 heifers and 75 steers averaging 220 kg, were used in a 187-d growing-finishing trial to study the influence of dietary salinomycin levels of 0, 5.5, 11, 16.5 and 22 mg/kg on rate and efficiency of gain. The basal diet to which the ionophore was added was composed largely to steam processed grains, and contained 3% supplemental fat. Performance responses to salinomycin supplementation were similar for steers and heifers. Rate of gain was not influenced (P greater than .20); however, feed conversion was improved by an average of 5% at the 11- to 22-mg/kg levels of salinomycin supplementation (P less than .05). Although not necessarily mutually exclusive, this improvement in feed conversion could be accounted for as either a 5% increase in the net energy value of the diet (P less than .05) or a 10% reduction in maintenance requirement (P less than .10). Four steer calves (234 kg) with cannulae in the rumen and proximal duodenum were used in a 4 X 4 Latin-square design trial to determine the influence of salinomycin supplementation on characteristics of digestion. Four levels of supplementation (0, 55, 11 and 16.5 mg/kg) were evaluated using the same basal diet as in the performance trial. Total tract digestion of organic matter, acid detergent fiber, starch and protein was not significantly altered by salinomycin supplementation. However, ruminal digestion of organic matter was reduced 6.2% (P less than .05). Neither ruminal degradation of feed protein nor net microbial synthesis was significantly altered.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002417:Cattle / Q000254:growth & development*; D004063:Digestion / Q000187:drug effects*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005260:Female; D007476:Ionophores / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000378:metabolism; D011714:Pyrans / Q000494:pharmacology; D000095662:Polyether Polyketides
chemical_list: D005232:Fatty Acids, Volatile; D007476:Ionophores; D008903:Minerals; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides