A study of the permeation of dihexadecyl phosphate vesicles by various anesthetics.
A simple spectroscopic method for the evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate (DHP) bilayers. The perturbers used were unconventional anesthetics (n-alcohols C1-C8; n-hexane and n-pentane) and conventional anesthetics (chloroform, methoxyflurane, halothane and enflurane). The results show a correlation between vesicle permeation by anesthetics and their clinical potency. Two modes of perturbation by which the anesthetics may induce vesicle permeation are proposed.
D000438:Alcohols; D000777:Anesthetics; D008954:Models, Biological; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010539:Permeability; D013329:Structure-Activity Relationship
D000438:Alcohols; D000777:Anesthetics; D010755:Organophosphates; D009943:Organophosphorus Compounds; C002290:dicetylphosphate