Mathematical analysis of transport phenomenon to the blood from the site of intramuscular injection with ampicillin in the rat.
The mathematical formula with time function of transport phenomenon is obtained by the analysis of the concentrations of ampicillin in the serum, bile and urine. This formula indicates the speed of transport of the drug, or the ratio of the vascular permeability of it for the administrated dose from the site of intramuscular injection into the blood as the time function. About 80% of ampicillin was transported into the blood through capillaries for 120 min from the beginning of intramuscular injection.
D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000818:Animals; D001646:Bile / Q000032:analysis; D001692:Biological Transport; D001693:Biological Transport, Active; D002199:Capillary Permeability; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008433:Mathematics; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000667:Ampicillin