title: Effect of arteriovenous flow reversal on blood flow and metabolism in a skin flap.
abstract: Twelve pig buttock island flaps (10 X 10 cm) were studied for 6 hours after arteriovenous flow reversal at the level of the pedicle. Follow-up was 48 hours. Blood pressure, Po2, pH, and lactate were measured in flap arteries and veins. Oxygen consumption was calculated. Data indicated true flow reversal. Blood pressure and Po2 in flap veins increased to systemic arterial levels. Outflow was provided by the arterial system, demonstrating venous pressure and Po2 values. Lactate increased significantly (1.8 +/- 0.5 to 4.0 +/- 2.3 mmol/liter), while pH dropped from 7.43 +/- 0.03 to 7.11 +/- 0.02. Oxygen consumption remained below baseline. In four flaps thrombosis occurred within 6 hours; no flap survived 48 hours. The results of this study do not encourage clinical application of the concept of flow reversal.
mesh_terms: D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects; D001794:Blood Pressure; D002081:Buttocks; D006863:Hydrogen-Ion Concentration; D008297:Male; D008866:Microsurgery / Q000379:methods*; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply* / Q000378:metabolism; D013524:Surgical Flaps; D013552:Swine; D014680:Veins / Q000502:physiology