title: Chronic incomplete obstruction of the ureter: a new experimental model.
abstract: To produce a chronic moderate hydronephrosis in dog, a method of partial ureteral occlusion using a specially designed polypropylene obturator was developed. In 11 of 14 dogs undergoing this procedure, excretory urography constantly revealed a moderate degree of hydronephrosis persisting for 7 weeks. Combination of this method in one ureter with the vaginal-cuff cutaneous ureterostomy, previously reported, in the contralateral ureter is a useful model for split renal function study of unilateral chronic hydronephrosis or obstructive nephropathy analogous to that of clinical case.
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006869:Hydronephrosis / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism; D012039:Regional Blood Flow; D012964:Sodium / Q000378:metabolism; D013997:Time Factors; D014517:Ureteral Obstruction / Q000503:physiopathology*
chemical_list: D012964:Sodium; D011188:Potassium