[Radioprotective properties of oxolinic acid].
Oxolinic acid was shown to produce a radioprotective effect on mice and a therapeutic radioprotective action on rats and hamsters. As to radioprotective efficiency, oxolinic acid is inferior to such known sulfur-containing agents as indolylalkylamines and alpha-adrenomimetics. But oxolinic acid has an important advantage over them, that is, the increase in radioresistance it induces persists for several hours. The radioprotective effectiveness of oxolinic acid prompts that it is expedient to search for new radioprotective preparations among specific inhibitors of DNA polymerase of replicative synthesis.
D000818:Animals; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010093:Oxolinic Acid / Q000627:therapeutic use* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents; D051381:Rats; D013997:Time Factors
D011837:Radiation-Protective Agents; D010093:Oxolinic Acid
Protivoluchevye svoĭstva oksolinovoĭ kisloty.