title: Comparative metabolism of fenitrothion in aquatic organisms. I. Metabolism in the euryhaline fish, Oryzias latipes and Mugil cephalus.
abstract: [14C]Fenitrothion at 0.1 ppm in running water is more rapidly absorbed in the killifish (Oryzias latipes) at 25 than at 15 degrees C to a similar plateau level, and bioaccumulation ratios of fenitrothion are 235 and 339, respectively. Water of higher salinity (23%) resulted in slightly higher accumulation ratios of fenitrothion in both killifish (303) and mullet, Mugil cephalus (179), than fresh water (235 and 30, respectively), but the half-lives are independent of temperature and salinity, with values of 0.24-0.36 day. Fenitrothion was metabolized primarily through hydrolysis by the killifish, demethylation by the mullet, and conjugation of the liberated phenol with glucuronic acid by both species. Although metabolism of the compound was not affected by the different salinities and temperatures in both fish, the glucuronide conjugate was more directly excreted into water under lower temperature and higher salinity conditions. 14C-labeled compounds are distributed primarily in the gall bladder as shown by whole-body radioautography.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D003532:Cyprinodontiformes / Q000378:metabolism*; D005278:Fenitrothion / Q000378:metabolism*; D005618:Fresh Water; D006207:Half-Life; D007700:Kinetics; D009990:Oryzias / Q000378:metabolism*; D010473:Perciformes / Q000378:metabolism*; D012623:Seawater; D013045:Species Specificity; D013696:Temperature; D014018:Tissue Distribution
chemical_list: D005278:Fenitrothion