Prinzmetal's angina during 5-fluorouracil chemotherapy.
Variant angina developed during intravenous 5-fluorouracil therapy in a patient without prior history of angina pectoris. Ambulatory electrocardiography demonstrated S-T segment elevation and ventricular ectopy during pain, whereas no symptoms or S-T segment changes occurred during placebo therapy. Prophylaxis with both nifedipine and diltiazem was successful in preventing recurrence. It is believed that 5-fluorouracil induced coronary vasospasm and that this was prevented by prophylactic calcium antagonist therapy. Drug-induced coronary artery spasm may be the cause of 5-fluorouracil-associated chest pain.
D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D003329:Coronary Vasospasm / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D004562:Electrocardiography; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D005472:Fluorouracil