[Interphase death of thymus cells in combined radiation-thermal injury against a background of prophylactic administration of alpha-tocopherol and indomethacin].
The administration of alpha-tocopherol prior to radiation and thermal affection enhances chromatin degradation in thymocytes, increases the number of pyknomorphic cells in the critical zone of thymus, and enhances injury to erythrocyte membranes. The preventive administration of indomethacin does not influence the interphase cell death.
D000818:Animals; D002056:Burns / Q000150:complications* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects*; D004353:Drug Evaluation, Preclinical; D007213:Indomethacin / Q000627:therapeutic use*; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects*; D014810:Vitamin E / Q000627:therapeutic use*
D008054:Lipid Peroxides; D011453:Prostaglandins; D014810:Vitamin E; D007213:Indomethacin
Interfaznaia gibel' kletok timusa pri kombinirovannom radiatsionno-termicheskom porazhenii na fone profilakticheskogo vvedeniia al'fa-tokoferola i indometatsina.