[Effect of metronidazole on the free thymidine content in the blood serum of irradiated mice].
The influence of a radiosensitizer, metronidazole, on the free thymidine content of blood serum of irradiated mice was studied in aerobic and hypoxic conditions. A heated metronidazole solution (1 mg/g) was administered intraperitoneally 30 min before irradiation of animals with a dose of 3 Gy. Thymidine concentration in blood serum was determined by the radioimmunological technique. The influence of metronidazole on the level of thymidinemia was only noted in the animals exposed under hypoxic conditions.
D000208:Acute Disease; D000818:Animals; D005720:Gamma Rays; D000860:Hypoxia / Q000097:blood; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D013936:Thymidine / Q000097:blood* / Q000528:radiation effects
D008795:Metronidazole; D013936:Thymidine
Vliianie metronidazola na soderzhanie svobodnogo timidina v syvorotke krovi obluchennykh mysheĭ.