title: Age-related chromatin condensation in flight muscle nuclei of the adult male housefly, Musca domestica.
abstract: Computer analysis of indirect flight muscle nuclei from the adult male housefly, M. domestica, has shown significant change with age in the chromatin condensation pattern. The pattern was analyzed by examining low, medium, and high density chromatin components (LDC, MDC, HDC). No significant change occurred in HDC with age, and the amount and distribution of LDC and MDC remain relatively stable between Day 1 and Day 4 post-eclosion. However, the analysis showed a significant increase in the amount of MDC with a corresponding decrease in the amount of LDC between Day 4 and Day 14. This exchange was accompanied by a significant redistribution of both components. These results are discussed with reference to the biochemical and ultrastructural profile of the flight muscle with age, and to age-related changes in the condensation pattern of specific brain and Malpighian tubule nuclei described earlier.
mesh_terms: D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005426:Flight, Animal; D006793:Houseflies / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D002843:Chromatin; D004247:DNA