Comparative efficacy of ketoconazole and mebendazole in experimental trichinosis.
The therapeutic efficacy of ketoconazole and mebendazole was studied in ICR/CD-1 mice infected with Trichinella spiralis for 17 to 20 weeks. Efficacy of both drugs was over 70% when compared with results in control mice. This study indicates that both ketoconazole and mebendazole should be considered in the treatment of trichinosis in humans.
D000818:Animals; D007654:Ketoconazole / Q000627:therapeutic use*; D008463:Mebendazole / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D014234:Trichinella / Q000187:drug effects; D014235:Trichinellosis / Q000188:drug therapy*
D008463:Mebendazole; D007654:Ketoconazole