Cytogenetic studies in secondary leukemia: statistical analysis.
Since the number of long-term survivors following radio- and/or chemotherapy for cancer increases, secondary leukemia is now a threatening complication. Several studies already showed that -5/5q-, -7/7q- and -17 were non-random chromosome changes in secondary leukemia. In this study, a statistical approach was used to better determine the non-randomness of the karyotypic abnormalities and to correlate these aberrations with clinical and demographic parameters. The results showed that these were 16 non-random changes involving chromosomes No. 3, 5, 7, 8, 9, 11, 14, 17 and 21. With the exception of -5/5q-, the chromosome changes were found to be dependent not only on the type of primary disease and previous therapy, but also on the sex and age of the patients.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D012737:Sex Factors; D014178:Translocation, Genetic
D000970:Antineoplastic Agents