[Mechanism of the radiation effect at the level of the supramolecular structures of eukaryotic DNA].
The methods of viscosimetry and light scattering were used to study the radiosensitivity of the supramolecular DNA (SM DNA) structure in vivo. Irreversible lesions were found in SM DNA 2 min after gamma-irradiation of rats with a dose of 10 Gy. They were associated with the damage to the RNA-lipoprotein component (a linker) and with the dissociation of SM DNA to fragments of different molecular weight, that is, 109 +/- 25 X 10(6), 51 +/- 15 X 10(6), and 47 +/- 21 X 10(6) D for liver, spleen, and thymus, respectively, which correlated with the radiosensitivity of these organs.
D000818:Animals; D004247:DNA / Q000187:drug effects / Q000528:radiation effects*; D004249:DNA Damage; D005720:Gamma Rays; D008027:Light; D008099:Liver / Q000187:drug effects / Q000528:radiation effects; D046911:Macromolecular Substances; D008297:Male; D008970:Molecular Weight; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D012542:Scattering, Radiation; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects; D014783:Viscosity
D046911:Macromolecular Substances; D004247:DNA
O mehanizme radiatsionnogo éffekta na urovne nadmolekuliarnykh struktur DNA éukariot.