title: Antiamebic activity of new acridinic derivatives against Naegleria and Acanthamoeba species in vitro.
abstract: In vitro antiamebic activity of selected acridine derivatives has been investigated against Naegleria and Acanthamoeba species. The most active compounds belong to the 9-thioacridanone and the 1,2,3,4-tetrahydro-9-thioacridanone series. In addition, some structure-activity relationships are proposed.
mesh_terms: D000166:Acridines / Q000494:pharmacology*; D000656:Amoeba / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines