[Prognostic significance of the glucocorticoid receptor level in the bone marrow blast cells of children with leukemias].
Glucocorticoid receptor (GR) levels of bone marrow blast cells were measured in 29 pediatric patients suffering different forms of acute leukemia. A decrease in GR level was registered immediately after prednisolone treatment. Differences in cell GR levels in patients with lymphoblastic and myeloblastic leukemia were not significant. The level of GR of bone marrow blast cells was found to be of prognostic significance in acute lymphoblastic leukemia: 4 out of 5 patients with GR levels under 3,000 sights per cell relapsed within 5-7 months of follow-up whereas all 7 cases with higher levels continue in remission. No correlation between GR level and prognosis was established in 5 patients with various forms of acute myeloblastic leukemia.
D000208:Acute Disease; D000293:Adolescent; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011379:Prognosis; D011965:Receptors, Glucocorticoid / Q000032:analysis*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid
Prognosticheskoe znachenie urovnia retseptorov gliukokortikoidov v blastnykh kletkakh kostnogo mozga deteĭ, bol'nykh leĭkozami.