Protection by parenteral iron administration against the inhalation toxicity of beryllium sulfate.
Animals exposed to an aerosol of BeSO4 showed a significant reduction in mortality with iron treatment. Rats were exposed for 2 h in a nose-only inhalation chamber for 14 days to an aerosol of 2.59 micrograms/Be/l. The cumulative mortality of animals concurrently treated with iron salt was significantly reduced (P less than 0.05) compared to animals which had not received iron treatment.
D000280:Administration, Inhalation; D000818:Animals; D001608:Beryllium / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D005290:Ferric Compounds / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D005290:Ferric Compounds; D000644:Quaternary Ammonium Compounds; C020711:beryllium sulfate; D001608:Beryllium; C013531:ferric ammonium citrate