title: 3H-tiotidine binding to guinea-pig cortical and striatal membranes.
abstract: 3H-Tiotidine has been identified as a suitable radioligand for the H2-receptor. We have confirmed and extended structure-binding affinity studies in the guinea-pig cortex, and established a structure-binding affinity relationship consistent with the H2-receptor in guinea-pig striatum. Cimetidine-displaceable 3H-tiotidine binding was observed also in the nucleus accumbens.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D002927:Cimetidine / Q000031:analogs & derivatives* / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D008566:Membranes / Q000378:metabolism
chemical_list: D002927:Cimetidine; C023990:tiotidine