title: [Mechanisms of the hemodynamic effects of nonachlazine in ischemic heart disease patients].
abstract: During course therapy with nonachlazine of patients with ischemic heart disease, stable angina pectoris a negative inotropic effect of the drug in persons with eukinetic and in particular hyperkinetic type of hemodynamics was revealed. Enhancement of beta-adrenoblocking effect of nonachlazine with an increase of its daily dose was found. Nonachlazine effect on hemodynamic parameters was shown to be mediated through adrenoreactive structures.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009628:Nonachlazine / Q000494:pharmacology* / Q000627:therapeutic use; D010640:Phenothiazines / Q000494:pharmacology*; D005082:Physical Exertion / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
chemical_list: D010640:Phenothiazines; D009628:Nonachlazine
vernacular_title: K voprosu o mekhanizmakh gemodinamicheskikh éffektov nonakhlazina u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.