Accumulation of globotriaosylceramide in a case of leiomyosarcoma.
Analysis of the glycosphingolipid composition in one case of uterine leiomyosarcoma metastasized to the liver showed an accumulation of globotriaosylceramide as compared with normal liver and uterus from which the tumour originated. The structure and the amount of glycosphingolipids were established by using specific glycosidases, permethylation analysis and h.p.l.c. The reason for the accumulation of globotriaosylceramide in leiomyosarcoma remains to be answered.
D002851:Chromatography, High Pressure Liquid; D005260:Female; D005915:Globosides / Q000378:metabolism*; D006028:Glycosphingolipids / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007890:Leiomyosarcoma / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008875:Middle Aged; D014281:Trihexosylceramides; D014594:Uterine Neoplasms / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D005915:Globosides; D006028:Glycosphingolipids; D014281:Trihexosylceramides; C018549:globotriaosylceramide