Lactate and pyruvate electrochemical biosensors for whole blood in extracorporeal experiments with an endocrine artificial pancreas.
Glucose, lactate, and pyruvate can be continuously measured in whole blood by using three extracorporeal electrochemical biosensors. We fixed two newly developed sensors, for lactate and pyruvate, in series with an endocrine artificial pancreas ("Betalike") without affecting its performance. These new sensors for use with whole blood should be able to clarify the fate of the intermediary metabolites of glucose in diabetic patients receiving infusions of drugs or insulin.
D001786:Blood Glucose / Q000032:analysis; D004563:Electrochemistry; D004800:Enzymes, Immobilized / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide; D007332:Insulin Infusion Systems; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D006899:Mixed Function Oxygenases / Q000378:metabolism; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011771:Pyruvate Oxidase / Q000378:metabolism; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid
D001786:Blood Glucose; D004800:Enzymes, Immobilized; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D006861:Hydrogen Peroxide; D006899:Mixed Function Oxygenases; C021497:lactate 2-monooxygenase; D011771:Pyruvate Oxidase