Hemoglobin concentration and prognosis in symptomatic obstructive cerebrovascular disease.
A total of 1,377 patients with symptomatic obstructive cerebrovascular disease (most commonly, internal carotid artery occlusion) entered a trial in which they were randomized to either medical or surgical (extracranial-intracranial bypass) therapy. All but 8 had hemoglobin estimations performed at entry. The patients were followed for an average of 55.8 months. In the medical group, the 325 patients with high normal hemoglobin concentration (15 g/l or more) suffered no more ischemic strokes than the 382 patients with lower values (less than 15 g/l). Those strokes that did occur were no more severe in the high than the low hemoglobin group. Hemoglobin concentration did not emerge as a prognostic factor in those patients treated surgically (n = 662). This prospective study counters the hypothesis that high normal hemoglobin concentration is associated with poor outcome in patients with symptomatic obstructive disease of the carotid and cerebral arteries.
D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000150:complications / Q000601:surgery / Q000628:therapy; D002548:Cerebral Revascularization; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000150:complications / Q000209:etiology / Q000401:mortality / Q000601:surgery / Q000628:therapy; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D009994:Osmolar Concentration; D011379:Prognosis; D011897:Random Allocation
D006454:Hemoglobins