[Effect of cobalamin derivatives on DNA synthesis in cells of Propionibacterium freudenreichii subsp. shermanii].
The increase of DNA-synthesis rate (according incorporation [8-14C]adenine) in B12-deficient cells Propionibacterium shermanii as a result of different cobalamines adding into the cell suspension including metoxyethyladenile analog of adenozilcobalamin and some components of vitamin B12 molecule has been found. The DNA-synthesis rate in B12-deficient cells is nearly twice lower as compared with one in B12-normal cells. Considerable stimulative effect (80-100%) was provided with coenzyme forms of cobalamin. The data confirm the participation of vitamin B12 in DNA-synthesis in Propionibacterium cells.
D004269:DNA, Bacterial / Q000096:biosynthesis* / Q000187:drug effects; D006918:Hydroxyurea / Q000494:pharmacology; D011424:Propionibacterium / Q000187:drug effects / Q000378:metabolism*; D014805:Vitamin B 12 / Q000031:analogs & derivatives / Q000494:pharmacology*
D004269:DNA, Bacterial; D014805:Vitamin B 12; D006918:Hydroxyurea
Vliianie proizvodnykh kobalamina na sintez DNK v kletkakh Propionibacterium freudenreichii subsp. shermanii.