Mutagenicity of 4-hydroxynonenal in V79 Chinese hamster cells.
4-Hydroxynonenal (HNE), a major product of the peroxidation of liver microsomal lipids, was examined for mutagenic activity at the hypoxanthine-guanine phosphoribosyltransferase locus in V79 Chinese hamster lung cells. At concentrations ranging from 10 to 45 microM, HNE induced a dose-dependent increase in the number of mutations to 6-thioguanine resistance, which reached the level of 4.7X baseline at the highest concentration tested.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects*; D008168:Lung; D008297:Male; D009152:Mutagenicity Tests
D000447:Aldehydes; C027576:4-hydroxy-2-nonenal