title: Microbial resistance to disinfectants: mechanisms and significance.
abstract: Drinking water disinfection provides the final barrier to transmission of a wide variety of potentially waterborne infectious agents including pathogenic bacteria, viruses, and protozoa. These agents differ greatly in their innate resistance to inactivation by disinfectants, ranging from extremely sensitive bacteria to highly resistant protozoan cysts. The close similarity between microorganism inactivation rates and the kinetics of chemical reactions has long been recognized. Ideally, under carefully controlled conditions, microorganism inactivation rates simulate first-order chemical reaction rates, making it possible to predict the effectiveness of disinfection under specific conditions. In practice, changes in relative resistance and deviations from first-order kinetics are caused by a number of factors, including microbial growth conditions, aggregation, and association with particulate materials. The net effect of all these factors is a reduction in the effectiveness and predictability of disinfection processes. To ensure effective pathogen control, disinfectant concentrations and contact times greater than experimentally determined values may be required. Of the factors causing enhanced disinfection resistance, protection by association with particulate matter is the most significant. Therefore, removal of particulate matter is an important step in increasing the effectiveness of disinfection processes.
mesh_terms: D002455:Cell Division / Q000187:drug effects; D004202:Disinfectants; D004203:Disinfection / Q000379:methods*; D004352:Drug Resistance, Microbial; D005243:Feces / Q000382:microbiology; D006801:Humans; D007700:Kinetics; D009154:Mutation; D010316:Particle Size; D013242:Sterilization / Q000379:methods*; D014871:Water Microbiology
chemical_list: D004202:Disinfectants