Aberrant H-2-like allospecificities on K36.16 thymoma. Studies by radiobinding and immunoprecipitation with anti-H-2 monoclonal antibodies.
The K36.16 thymoma expresses an H-2Dd-like allospecificity as detected by the 34-5-8 monoclonal antibody directed against H-2Dd using immunoprecipitation techniques. This monoclonal antibody gives a negative result by radio-immune assay but other anti-Dd antibodies react positively with this tumour. These results confirm and extend previous observations and are attributed to probable gene-conversion events possibly involving a donor gene from the Qa/Tla region, the products of which cross-react with Dd.
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000235:genetics; D002478:Cells, Cultured; D003429:Cross Reactions; D005785:Gene Conversion; D006183:H-2 Antigens / Q000235:genetics; D051379:Mice; D008806:Mice, Inbred AKR; D013945:Thymoma / Q000235:genetics / Q000276:immunology*; D013953:Thymus Neoplasms / Q000235:genetics / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006183:H-2 Antigens