Erythrocyte water content in spontaneously hypertensive rats and DOCA-salt hypertensive rats.
Intra-erythrocyte water, sodium and potassium contents were measured in spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)-salt rats. In 12 week old SHR, the intra-erythrocyte water content was slightly but significantly lower than that in age-matched Wistar-Kyoto (WKY) rats. SHR also exhibited a significantly lower intra-erythrocyte potassium content, but sodium content tended to be elevated. Although sodium content was not correlated with the water content, potassium content was. In DOCA-salt hypertensive rats, the intra-erythrocyte sodium content was higher than that in age-matched normotensive Sprague-Dawley rats by about 33%, but the water and potassium contents were similar. There were no significant correlations between these parameters. These findings provide no evidence of water retention in erythrocytes from DOCA-salt rat or SHR even though intra-erythrocyte sodium content was increased.
D000818:Animals; D001794:Blood Pressure; D002849:Chromatography, Gas; D003900:Desoxycorticosterone; D004912:Erythrocytes / Q000378:metabolism*; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced; D008297:Male; D011188:Potassium / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood*; D012965:Sodium Chloride; D014882:Water-Electrolyte Balance
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D012964:Sodium; D011188:Potassium