Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia.
Extracts from the tumours of three patients with oncogenic osteomalacia stimulated renal adenylate cyclase in a parathyroid hormone (PTH) responsive system. The stimulation was suppressed by a specific PTH antagonist. These observations suggest that osteomalacia-producing tumours exert some of their effects through PTH-like material acting on PTH receptors.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001681:Biological Assay; D001859:Bone Neoplasms / Q000378:metabolism*; D002645:Chickens; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D008297:Male; D010018:Osteomalacia / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000378:metabolism*; D013577:Syndrome; D014020:Tissue Extracts / Q000494:pharmacology
D010281:Parathyroid Hormone; D014020:Tissue Extracts; D000262:Adenylyl Cyclases