[Local use of metronidazole in dimethyl sulfoxide in the radiation therapy of cervical cancer].
A method of the local use of metronidazole dissolved in dimethylsulfoxide (DMSO) for cervix uteri cancer patients was worked out. Applications of 1-2 g of metronidazole were well tolerated by the patients. Metronidazole concentrations in cervical tumors were high (about 1000 micrograms/g), in the blood they did not exceed 16 micrograms/ml. Experiments showed that metronidazole in DMSO diffused in the tissue, its concentrations at a distance of 2-3 cm from the surface were 180-260 micrograms/g. The local use of metronidazole in DMSO caused an increase in the rate of tumor radiation regression.
D000287:Administration, Topical; D000818:Animals; D003131:Combined Modality Therapy; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D051381:Rats; D012996:Solutions; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*
D012996:Solutions; D008795:Metronidazole; D004121:Dimethyl Sulfoxide
Lokal'noe primenenie metronidazola v dimetilsul'fokside pri luchevoĭ terapii raka sheĭki matki.