title: [A variant of pathogenetic therapy in the acute period of perinatal hypoxic-traumatic brain lesions in premature infants].
abstract: The restorative potential of reparative cellular processes was studied in 39 immature infants born in hypoxia and receiving a pathogenetic treatment. In addition to the conventional treatment the test group of 24 infants received intravenously 20% piracetam solution, 1% riboflavin-mononucleotide solution, and 0.5% lipoic acid solution beginning from the first days of life. To correct the cellular metabolic processes in a control group of 15 infants, they were given 10% glucose solution, 5% ascorbic acid solution and cocarboxylase. The activity of dehydrogenases in the peripheral blood remained virtually unaltered in the control group but increased by an average of 1.5-2 times in the test group. An 18-month follow-up ascertained that the incidence of neurological complications in the infants receiving the proposed treatment was significantly lower as against the control patients.
mesh_terms: D000208:Acute Disease; D001238:Asphyxia Neonatorum / Q000150:complications; D001720:Birth Injuries / Q000150:complications; D003131:Combined Modality Therapy; D003422:Critical Care; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology / Q000628:therapy*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*
vernacular_title: Variant patogeneticheskoĭ terapii v ostrom periode perinatal'nykh gipoksicheski-travmaticheskikh povrezhdeniĭ mozga u nedonoshennykh deteĭ.