title: Tibial dyschondroplasia in single-comb White Leghorn chicks fed tetramethylthiuram disulfide (a fungicide).
abstract: Supplementing a practical chick starter diet with 30 mg tetramethylthiuram disulfide per kg of diet produced tibial dyschondroplasia (TD) in single-comb white leghorn chicks without compromising growth or bone mineralization. The incidence and severity of the lesion increased over time, with the highest incidence (40%) occurring in 4-week-old chickens. Microscopically, the lesion was consistent with the description of TD in broilers. This is the first known report of TD in the layer-type chick, which heretofore was felt to be highly resistant to TD.
mesh_terms: D000818:Animals; D002645:Chickens; D010009:Osteochondrodysplasias / Q000139:chemically induced / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced*; D013859:Thiocarbamates / Q000009:adverse effects*; D013893:Thiram / Q000009:adverse effects*; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
chemical_list: D013859:Thiocarbamates; D013893:Thiram