Tritiated thymidine uptake in chondrocytes of chickens afflicted with tibial dyschondroplasia.
3H-Thymidine was localized in sections of growth-plate cartilage and associated tibial dyschondroplastic lesion by autoradiography. One hour after 3H-thymidine was injected, radioactivity was found in the proliferating zone; after 48 hr it was also in the hypertrophic zone, and by 96 hr it was present in cells that were 4 to 5 mm into the lesion. This indicates that the lesion develops from the growth plate itself. The life span of the cells in the growth plate appears to be about 48 hr.
D000818:Animals; D001345:Autoradiography; D002455:Cell Division; D002645:Chickens; D006132:Growth Plate / Q000378:metabolism* / Q000473:pathology; D007700:Kinetics; D010009:Osteochondrodysplasias / Q000378:metabolism / Q000662:veterinary*; D011201:Poultry Diseases / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism*; D013977:Tibia / Q000378:metabolism* / Q000473:pathology; D014316:Tritium
D014316:Tritium; D013936:Thymidine