Platelet-activating factor induces the expression of early pregnancy factor activity in female mice.
When synthetic platelet-activating factor (PAF, 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) was injected into mature female mice during dioestrus, pro-oestrus or oestrus, it induced the expression of early pregnancy factor (EPF) activity in the sera of these animals within 1 h of injection. The sera of similarly injected males, metoestrous or immature females did not display any EPF activity. The results suggest that embryo-derived PAF may be the ovum factor responsible for triggering the generation of serum EPF activity during the preimplantation stages of pregnancy.
D000818:Animals; D018835:Chaperonin 10; D004971:Estrus; D005260:Female; D007166:Immunosuppressive Agents / Q000097:blood*; D010455:Peptides; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000494:pharmacology; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic
D018835:Chaperonin 10; D007166:Immunosuppressive Agents; D010455:Peptides; D010972:Platelet Activating Factor; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor; C026613:1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine