title: Behavioral effects of cyclic dosing with methylmercury in pigeons.
abstract: The present experiments examined the effects of cyclic dosing with methylmercury (MeHg) on some psychological functions in pigeons. A delayed sequence discrimination task involving order competency and a feeding task involving perceptual motor skill were tested in pigeons dosed with 2.0 mg/kg, 0.5 mg/kg, or no MeHg (the control group) during cycles of brief daily MeHg exposure and extended behavioral testing. Performance in the sequence discrimination and the feeding task was affected after a cumulative dose of only 20 mg/kg in the 2.0 mg/kg group. Sequence discrimination recovered within three months after dosing when MeHg was stopped, but feeding skill did not recover over the remainder of the experiment (about 4 1/2 months later). A cumulative dose of 86 mg/kg in the 0.5 mg/kg group had no observable effect on either task.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D010856:Columbidae; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D008767:Methylmercury Compounds / Q000378:metabolism / Q000633:toxicity*; D009899:Optic Lobe, Nonmammalian / Q000187:drug effects / Q000473:pathology; D011597:Psychomotor Performance / Q000187:drug effects*; D013997:Time Factors; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D008767:Methylmercury Compounds