Uptake, distribution and elimination of 3H-gentamicin in different organs of the rat as determined by scintillation counting.
Radioactivity attained in different tissues at different times after a single intraperitoneal injection of 3H-gentamicin into male rats was determined using scintillation counting. After about 30 min. kidney cortex demonstrated 3- to several hundred-fold greater radioactivity than other tissues. Gentamicin was released from kidney medulla and the urinary bladder relatively rapidly, whereas the radioactivity in kidney cortex and thoracal cartilage was maintained for at least 6 hrs.
D000818:Animals; D002356:Cartilage / Q000378:metabolism; D005260:Female; D005839:Gentamicins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012588:Scintillation Counting; D012737:Sex Factors; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000378:metabolism
D005839:Gentamicins