[The effect of reflux of bile juice on the development of residual stomach cancer].
An experimental study was performed using an organ culture method to evaluate the effect of a duodenal juice reflux on the development of cancer in the residual stomach. The following results were as follows. An intracellular DNA levels to combine with carcinogenic agents was significantly increased in the mucosa of the residual stomach compared to the parietal mucosa in the whole stomach (control group). In the human gastric mucosa exposed to the bile acid, the intracellular DNA level to combined with carcinogenic agents was increased, and thus the effect of the bile acid as a surfactant on the experimental development of gastric cancer was suggested. An atrophic change was main feature of the residual stomach. Autoradiographic findings revealed that the proliferative zone was extended and a number of immature cells appeared which became to be target cells. Therefore, the residual stomach might provide a situation where the cancer would easily develop.
D001647:Bile Acids and Salts / Q000502:physiology; D001655:Bile Reflux / Q000150:complications*; D001660:Biliary Tract Diseases / Q000150:complications*; D003043:Cocarcinogenesis; D004247:DNA / Q000378:metabolism; D004386:Duodenum / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007419:Intestinal Secretions / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000378:metabolism; D009924:Organ Culture Techniques; D013274:Stomach Neoplasms / Q000209:etiology*
D001647:Bile Acids and Salts; D008769:Methylnitronitrosoguanidine; D004247:DNA