title: In vitro activity of CI-934 and other antimicrobial agents against gram-positive and gram-negative bacteria.
abstract: The activity of CI-934, a new carboxy-quinolone antibiotic, against gram-positive cocci and bacilli and gram-negative bacilli was compared with that of reference antibiotics. CI-934 demonstrated excellent activity against gram-positive organisms, including Corynebacterium sp. In addition, although the activity of CI-934 against gram-negative bacilli was less than that reported for similar agents, it was comparable to that of aminoglycosidic aminocyclitol antibiotics.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011804:Quinolines; C047718:CI 934