title: Comparative metabolism of fenitrothion in aquatic organisms. II. Metabolism in the freshwater snails, Cipangopaludina japonica and Physa acuta.
abstract: When freshwater snails, Cipangopaludina japonica and Physa acuta, were exposed to 0.1 ppm [14C]fenitrothion in a dynamic flow system, the concentrations of fenitrothion and 14C in the body reached equilibrium on Day 1 of exposure. The maximum bioaccumulation ratios of fenitrothion were 18 and 53 in C. japonica and P. acuta, respectively. These snails metabolized the compound primarily by demethylation, hydrolysis, and reduction. The liberated phenol moiety was found to be conjugated with sulfate in C. japonica and mainly with glucose in P. acuta. When the snails were transferred to a freshwater stream, fenitrothion and its metabolites were rapidly excreted, and the half-life of the parent compound was less than 0.5 day in both snails. Fenitrothion and its decomposition products were mainly distributed in liver of P. acuta, as evidenced by whole-body radioautography.
mesh_terms: D000818:Animals; D001345:Autoradiography; D005278:Fenitrothion / Q000378:metabolism*; D005880:Gills / Q000378:metabolism; D006207:Half-Life; D008168:Lung / Q000378:metabolism; D012908:Snails / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution
chemical_list: D005278:Fenitrothion