title: [Histochemical study of reverse reactions in experimental leprosy in armadillos].
abstract: Morphological and histochemical characteristics of reverse reactions in M. leprae-infected armadillos are reviewed. The reverse reactions develop in generalized lepromatous disease and are characterized by a dramatic decrease in mycobacterial macrophage load and the appearance of lymphocytes, epithelioid and giant multinuclear cells with peripheral nucleus distribution. Histochemical investigation has shown a decrease in the activity of redox enzymes and alpha-naphthyl acetate esterase and an increase in beta-glucuronidase activity. The reverse reactions in the liver are accompanied by hepatic granuloma and hepatocyte destruction.
mesh_terms: D000818:Animals; D001135:Armadillos; D001706:Biopsy; D004817:Epidermis / Q000201:enzymology / Q000648:ultrastructure; D006651:Histocytochemistry; D007918:Leprosy / Q000201:enzymology* / Q000473:pathology; D008264:Macrophages / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D012075:Remission, Spontaneous; D013997:Time Factors; D004490:Xenarthra
vernacular_title: Gistokhimicheskoe izuchenie reversivnykh reaktsiĭ pri éksperimental'noĭ lepre u bronenostsev.