title: Cytogenetic analyses in 89 patients with secondary hematologic disorders--results of a cooperative study.
abstract: Eighty-nine patients who developed a secondary hematologic disorder and were studied with chromosome analysis were collected from nine institutions. The results of the study confirmed previous findings, in particular, -5/5q-, -7/7q-, -17, and +21 were the most frequently encountered aberrations. Moreover, a t(1;7)(p11;p11) was reported in four cases and consistent chromosome abnormalities were observed in a small group of patients who had been treated only with surgery, but not with chemo- or radiotherapy for a previous tumor.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002277:Carcinoma / Q000235:genetics / Q000628:therapy; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000139:chemically induced / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000209:etiology / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D011832:Radiation Injuries / Q000209:etiology / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents