title: Ability of ethoxyquin and butylated hydroxytoluene to counteract deleterious effects of dietary aflatoxin in chicks.
abstract: The antioxidants ethoxyquin and butylated hydroxytoluene (BHT) were added to diets of chicks in concentrations three and eight times above that usually found in poultry feed beginning 15 days after hatch; the chicks had been placed on feed containing 1000 or 3000 ppb aflatoxin on the day of hatch. These diets were continued until chicks were 6 weeks of age. At that time, deleterious effects of aflatoxin on weight gain, feed efficiency, and organ weights (spleen, bursa) were evident. BHT alleviated these effects, but ethoxyquin did not. Pretreatment with ethoxyquin did not protect chicks either. Ethoxyquin was not able to induce the activities of chick liver enzymes that detoxify aflatoxin and other foreign compounds. Lack of effect of ethoxyquin on these enzymes may hinder ability of this antioxidant to protect chicks from aflatoxin.
mesh_terms: D000348:Aflatoxins / Q000633:toxicity*; D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D002645:Chickens / Q000254:growth & development*; D005015:Ethoxyquin / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000139:chemically induced* / Q000188:drug therapy; D011804:Quinolines / Q000627:therapeutic use*
chemical_list: D000348:Aflatoxins; D011804:Quinolines; D002084:Butylated Hydroxytoluene; D005015:Ethoxyquin