Serum sickness associated with cefoxitin and pentoxifylline therapy.
Human serum sickness is a syndrome characterized by fever, malaise, skin rashes, arthralgias, gastrointestinal disturbances, and lymphadenopathy. It is believed to be mediated by circulating immune complexes composed of a foreign antigen and host antibody. Several cephalosporins have been associated with serum sickness. We report the occurrence of serum sickness in a patient who received cefoxitin, a commonly used cephamycin antibiotic, and pentoxifylline, a xanthine derivative that improves the flow properties of blood by decreasing its viscosity. Serum sickness has not been previously reported with the use of cefoxitin or pentoxifylline.
D002440:Cefoxitin / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000009:adverse effects*; D012713:Serum Sickness / Q000139:chemically induced*; D013805:Theobromine / Q000031:analogs & derivatives*
D002440:Cefoxitin; D013805:Theobromine; D010431:Pentoxifylline