title: [Preoperative thermoradio- and thermochemotherapy of breast cancer].
abstract: Thermoradio- and thermochemotherapy were employed for the treatment of 85 patients with stage II-III breast cancer. 80 patients of the control group were given either radio- or chemotherapy. In 3 hrs large fractions of irradiation (a single focal dose of 6 Gy and total focal dose of 18 Gy) of the breast, axillary and subclavicular regions or chemotherapy (i.v. injection of vincristine, 5-FU, cyclophosphamide and methotrexate) were followed by local MWF-hyperthermia (915 MHz) to 43 degrees C tumor temperature for 60 min. 3-day treatment was followed by mastectomy on the 4th day. Preoperative thermoradio- and thermochemotherapy made it possible to achieve pronounced pathomorphosis of breast cancer in most of the patients during 3 days, to lower tumor malignancy and the danger of intraoperative metastases.
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy / Q000379:methods; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D011879:Radiotherapy Dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Predoperatsionnaia termoradio- i termokhimioterapiia raka molochnoĭ zhelezy.