[Pharmacological activity of the furfuryl amine salt of 4-chloro-N-(2-furylmethyl)-5-sulfamoyl anthranilic acid].
Furfuryl amine salt of 4-chloro-N-(2-furylmethyl)-5-sulfamoyl anthranilic acid was shown to exert more pronounced diuretic and saluretic action in rats, mice and dogs than that of furosemide. The previous administration of furfuryl amine salt of furosemide promoted normalization of the excretory processes of the kidney and increased survival rate of rats in ischemia of the single kidney. The antiedema activity of the drug was found to be much more pronounced than that of furosemide.
D058186:Acute Kidney Injury / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology* / Q000627:therapeutic use; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D007511:Ischemia / Q000150:complications / Q000188:drug therapy; D007668:Kidney / Q000098:blood supply; D008297:Male; D051379:Mice; D009318:Natriuresis / Q000187:drug effects; D051381:Rats; D013424:Sulfanilamides / Q000494:pharmacology* / Q000627:therapeutic use; D062367:ortho-Aminobenzoates / Q000494:pharmacology* / Q000627:therapeutic use
D004232:Diuretics; D013424:Sulfanilamides; D062367:ortho-Aminobenzoates; C051603:4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid; D005665:Furosemide
Farmakologicheskaia aktivnost' furfurilaminovoĭ soli 4-khlor-N-(2-furilmetil)-5-sul'famoilantranilovoĭ kisloty.