Massive hepatomegaly following splenectomy for myeloid metaplasia. Case report and review of the literature.
Massive compensatory hepatic myeloid metaplasia occurs infrequently after splenectomy for myeloid metaplasia, and it usually develops gradually over several years if it does occur. In this report, a patient is described in whom massive hepatomegaly and evidence of portal hypertension developed within three months of splenectomy. Early evidence for rapid hepatic growth was present at a second laparotomy three weeks after the first surgery, and probably should have triggered initiation of chemotherapy. Indications for splenectomy in these patients, surgical morbidity, and response to splenectomy are discussed.
D006529:Hepatomegaly / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications; D055728:Primary Myelofibrosis / Q000209:etiology / Q000628:therapy*; D012086:Reoperation; D013156:Splenectomy / Q000009:adverse effects*; D013997:Time Factors