[Subacute septicemia caused by Meningococcus of serogroup Y and acquired deficiency of complement C3 fraction].
The high frequency of meningococcal infections in patients with congenital deficiency of a component of the complement terminal pathway emphasizes the critical role of this system in host resistance against Neisseriaceae. We report the observation of a subacute septicaemia due to N. meningitidis serogroup Y. This girl had an acquired deficit of the C3 fraction of complement due to a high titre of C3 nephritic factor (C3NeF). There was no evidence of partial lipodystrophy or biological symptoms of glomerular disease. The meningococcal infection revealed this biological abnormality.
D002648:Child; D003176:Complement C3 / Q000172:deficiency*; D003178:Complement C3 Nephritic Factor / Q000097:blood; D005260:Female; D006801:Humans; D008589:Meningococcal Infections; D018805:Sepsis / Q000209:etiology*
D003176:Complement C3; D003178:Complement C3 Nephritic Factor
Septicémie subaiguë à méningocoque du sérogroupe Y et déficit acquis en facteur C3 du complément.