[Unscheduled DNA synthesis in human peripheral blood lymphocytes undergoing combined exposure to gamma irradiation and methylmethane sulfonate].
The value of the unscheduled DNA synthesis by exposure to combined action of damaging agents--gamma-irradiation and methyl methanesulfonate--does not exceed its value after separate actions of each particular agent in lymphocytes from healthy subjects as well as in those with Xeroderma pigmentosum in form II (XP2LE). This result is due to inhibiting effects of alkylating agents on DNA-polymerases.
D000328:Adult; D001345:Autoradiography; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D013997:Time Factors; D014316:Tritium; D014983:Xeroderma Pigmentosum / Q000097:blood
D014316:Tritium; D004247:DNA; D008741:Methyl Methanesulfonate
Vneplanovyĭ sintez DNK v limfotsitakh perifericheskoĭ krovi cheloveka pri kombinirovannom deĭstvii gamma-oblucheniia i metilmetansul'fonata.