title: [Efficacy of corvaton in the long-term ambulatory treatment of heart failure in patients with rheumatic heart lesions].
abstract: Corvaton treatment of 23 patients with congestive heart failure caused by rheumatic valvular heart diseases, continued for 10 mos. An increase in the stroke and minute blood volume in the chest, leg and fingers, and a decrease in the peripheral vascular resistance and systolic pressure in the pulmonary artery were noted as a result of corvaton therapy. Corvaton efficacy was assessed by change in hemodynamics for 2 h after administration of the drug at a single dose of 4 mg. A response of hemodynamics to corvaton was preserved for 10 mos.
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications; D008946:Mitral Valve Stenosis / Q000150:complications; D008981:Molsidomine / Q000494:pharmacology / Q000627:therapeutic use*; D012214:Rheumatic Heart Disease / Q000150:complications*
chemical_list: D008981:Molsidomine
vernacular_title: Effektivnost' korvatona v protsesse dlitel'nogo ambulatornogo lecheniia serdechnoĭ nedostatochnosti u bol'nykh revmaticheskimi porokami serdtsa.