Inhibition of cadmium teratogenesis by a mercaptoacrylic acid (MFA).
The teratogenic effect of cadmium can be diminished by a number of mechanisms including zinc and pretreatment with cadmium and mercury. In this study, the oral administration of alpha-mercapto-beta-(2-furyl)-acrylic acid (MFA) protects against cadmium-induced malformations and embryonic death. This protection is probably mediated by the chelation of the cadmium ion rather than metallothionein (MT) synthesis.
D000014:Abnormalities, Drug-Induced; D000179:Acrylates / Q000494:pharmacology*; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D006224:Cricetinae; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008668:Metallothionein / Q000096:biosynthesis; D011247:Pregnancy; D013723:Teratogens
D000179:Acrylates; D013723:Teratogens; D002104:Cadmium; C015341:2-mercapto-3-furan-2-ylpropenoic acid; D008668:Metallothionein