title: Influence of dietary protein on motor fluctuations in Parkinson's disease.
abstract: On a nearly zero protein diet, 11 patients with Parkinson's disease with the "on-off" effect demonstrated great sensitivity to levodopa (L-dopa)-carbidopa and reduced fluctuations. Eight patients required a 41% reduction in total L-dopa dosage and discontinuation of all adjuvant therapy to reduce the preponderance of chorea. On a high-protein diet, all patients were immobilized by bradykinesia for most of the day. A low-protein dietary regimen during the daytime offers an important technique for the control of fluctuations in patients with Parkinson's disease who are receiving L-dopa-carbidopa.
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000178:diet therapy* / Q000188:drug therapy
chemical_list: D004044:Dietary Proteins; D007980:Levodopa