title: [Differential drug therapy and prevention of different types of atrial fibrillation in ischemic heart disease patients].
abstract: Clinical and instrumental examination using enhanced atrial VCG and ECG in 140 patients with coronary heart disease complicated by frequent atrial fibrillation paroxysms (AFP) identified 3 types of atrial myocardial change: the "hemodynamic" or secondary atrial fibrillation, "arrhythmic", or primary atrial fibrillation, and "ischemic" ones, the former 2 types being particularly common. These pathogenetic differences taken into account, long-term differential therapy and prevention of AFP became possible where cordaron proved the most effective agent (74% response rate). Its effectiveness approached 83% in primary AFP and was somewhat lower (42%) in secondary AFP, while digoxin proved more efficient in the latter group (52%). Cordaron treatment was associated with a 9.2% side effects rate; low doses of the drug produced no side effects.
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D002301:Cardiac Glycosides / Q000627:therapeutic use; D002908:Chronic Disease; D003327:Coronary Disease / Q000150:complications* / Q000188:drug therapy; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002301:Cardiac Glycosides
vernacular_title: Differentsirovannaia medikamentoznaia terapiia i profilaktika razlichnykh tipov mertsatel'noĭ aritmii u bol'nykh s ishemicheskoĭ bolezn'iu serdtsa.