Timolol and cornea.
The influence of timolol on the corneal epithelium and endothelium was studied in organ culture. The cell morphology was not influenced by drug concentrations less than or equal to 690 micrograms/ml. Cell death was observed at 6900 micrograms/ml. Endothelial cell proliferation after an experimental injury was slowed down at a drug concentration of 690 micrograms/ml. Injurious effects were not observed at the drug concentrations found in the aqueous humour by use of ophthalmic eye solution in eyes with a normal cornea. However, it may be indicated to use eye drops with reduced concentration of timolol in conditions facilitating the resorbtion of the drug.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D004727:Endothelium / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009924:Organ Culture Techniques; D011817:Rabbits; D013999:Timolol / Q000494:pharmacology*
D013999:Timolol