Induced synthesis of metallothionein by ascorbic acid in mouse liver.
The concentration of metallothionein in mouse tissues after administration of ascorbic acid was determined by the Cd-hem method. The concentration of metallothionein in the liver was increased significantly after an intraperitoneal injection of L-ascorbic acid at the dose of 1000 mg/kg. A simultaneous injection of cycloheximide inhibited the increase of the metallothionein concentration. Mortality of mice injected with a lethal dose of cadmium was decreased significantly by the pre-injection of L-ascorbic acid. All of these results indicate that metallothionein is induced in the liver after the administration of ascorbic acid.
D000818:Animals; D001205:Ascorbic Acid / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D015032:Zinc / Q000032:analysis
D008668:Metallothionein; D003513:Cycloheximide; D015032:Zinc; D001205:Ascorbic Acid