[Effect of splenectomy on cancers induced with ENNG (N-ethyl-N'-nitro-N-nitroso-guanidine) in the alimental canal].
The effect of splenectomy on cancers in the alimental canal induced with ENNG was investigated. Wistar rats were given 100 micrograms/ml ENNG in tap water ad libitum for four months. Splenectomy was carried out one month on group A (n = 19), two months on group B (n = 18), three months on group C (n = 19) and four months on group D (n = 16) after administration of ENNG. In the control group splenectomy was not performed and ENNG was only given. For the results, the size of tumors in group A and B rats were grossly reduced compared with group C and D rats. Histologically, epithelial tumors seemed to be differentiated in group A and B rats compared with those of group C and D rats. In the early stage when it was difficult to determine the tumors macroscopically and histologically, splenectomy seemed to inhibit the growth of alimental tumors induced with ENNG and splenectomy itself seemed to decrease the growth of alimental tumors induced with ENNG.
D000818:Animals; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D013156:Splenectomy
D008769:Methylnitronitrosoguanidine; C013525:ENNG