title: Importance of diet of dam and colostrum to the biological antioxidant status and parenteral iron tolerance of the pig.
abstract: Fifteen second-parity sows were used to determine the importance of vitamin E (E) and selenium (Se) supplementation of the sow's diet and colostrum consumption by the neonatal pig on tolerance to parenteral iron. Selenium (.1 ppm) and E (50 IU/kg) supplementation of the diet of the sow increased plasma tocopherol and Se concentrations, but did not increase plasma glutathione peroxidase (GSH-Px) activity. Colostrum had greater concentrations of E (primarily alpha-tocopherol) and Se than milk. Plasma biological antioxidant status (tocopherol level and GSH-Px activity) of pigs at birth was very low, but by 2 d of age had increased, especially in alpha-tocopherol (nearly a 20-fold increase). Liveability and body weight gain of pigs were not affected by the pre-colostrum iron injection (200 mg Fe as gleptoferron); however, plasma tocopherol concentrations of Fe-injected pigs were lower and plasma Se concentration and GSH-Px activities were higher at 2 d of age than values of pigs not receiving parenteral Fe. Supplementation of the dam's diet with E and Se maintained high tocopherol and Se levels in her colostrum and milk and a high biological antioxidant status in her pigs throughout the nursing period.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003126:Colostrum / Q000032:analysis*; D005260:Female; D007501:Iron / Q000494:pharmacology*; D008892:Milk / Q000032:analysis; D011247:Pregnancy; D020887:Selenious Acid; D012643:Selenium / Q000097:blood / Q000494:pharmacology*; D013552:Swine / Q000097:blood*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D014810:Vitamin E; D007501:Iron; D020887:Selenious Acid; D024502:alpha-Tocopherol; D012643:Selenium; D024505:Tocopherols