title: Species specificity of thrombin-induced changes in vascular tone.
abstract: We studied the effects of acetylcholine and human thrombin on the tone of rabbit and dog isolated femoral arteries and aortas with intact endothelium. Acetylcholine (10(-9)-10(-6) mol/l) produced relaxation in the vessels from both species whereas thrombin (10(-9)-3 X 10(-8) mol/l) relaxed only canine arterial smooth muscle. Thrombin pretreatment increased significantly the relaxant potency of acetylcholine in femoral arteries of dogs. The results suggest an interspecies difference in the thrombin-induced endothelium-dependent vasorelaxation.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004727:Endothelium / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D013045:Species Specificity; D013917:Thrombin / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D013917:Thrombin; D000109:Acetylcholine