title: Identical twins discordant for presenile dementia of the Alzheimer type.
abstract: In genetically proven identical female twins, discordant for presenile dementia of the Alzheimer type, the affected twin began to dement at the age of 49, and died 15 years later; the diagnosis was confirmed at post-mortem. The surviving twin remains clinically unaffected 20 years after the onset of dementia in her sister. Environmental aetiological factors are postulated to account for this discordance.
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D008875:Middle Aged; D014430:Twins, Monozygotic