title: Ketamine depression of excitatory and inhibitory cholinergic responses in Aplysia neurons.
abstract: The effects of ketamine on the cholinergic excitatory and inhibitory (Cl component) responses in Aplysia neurons were examined using the iontophoretic application of ACh and the two-microelectrode voltage clamp technique. Ketamine reduced both responses non-competitively to the same extent in a dose-dependent and reversible manner at concentrations between 10(-6) and 10(-3) M, without changing the reversal potentials. These findings suggest that ketamine depresses the cholinergic responses by affecting the gating mechanism at postsynaptic membranes.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000818:Animals; D001048:Aplysia; D003250:Constriction; D066298:In Vitro Techniques; D007478:Iontophoresis; D007649:Ketamine / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*
chemical_list: D007649:Ketamine; D000109:Acetylcholine