title: Social isolation and tolerance development to sodium barbital in mice.
abstract: The effect of the duration of isolation periods on the development of tolerance to sodium barbital was studied in mice. The HD50 values for pentobarbital-induced hypnosis were higher in all mice that were long-term treated with sodium pentobarbital, whether or not they were isolated or in groups. Diazepam HD50s were higher in mice isolated and long-term treated with sodium barbital for 38 days and in grouped animals treated with the barbiturate for 20 and 30 days. Social isolation for 8 weeks plus 23 days increased the pentobarbital hypnotic dose (HD50). These data show that social isolation increased the rate of tolerance acquisition to sodium barbital by mice.
mesh_terms: D000818:Animals; D001462:Barbital / Q000378:metabolism*; D001463:Barbiturates / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010424:Pentobarbital / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D012934:Social Isolation
chemical_list: D001463:Barbiturates; D001462:Barbital; D010424:Pentobarbital; D003975:Diazepam