Histopathology of herpes simplex virus keratouveitis.
Twenty-four eyes removed for complications of HSV keratitis were studied histopathologically. There were 20 men and 4 women with an average age of 61 years. Severe keratitis was seen in 14, moderate in 7, and mild in 3 eyes. Common features associated with severe keratitis were: acute perforation, granulomatous keratitis with giant cells in the stroma and Descemet's region, stromal inflammatory cells, angle-closure, severe iridocyclitis with diffuse or focal infiltration of lymphocytes and plasma cells, low-grade vitritis, choroiditis, and/or retinal periphlebitis. Specimens with moderate to mild keratitis had a similar distribution of inflammation but a lower incidence of granulomatous keratitis.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology; D002833:Choroiditis / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology / Q000473:pathology; D005260:Female; D005901:Glaucoma / Q000209:etiology / Q000473:pathology; D006099:Granuloma / Q000209:etiology / Q000473:pathology; D006801:Humans; D007498:Iris / Q000473:pathology; D007635:Keratitis, Dendritic / Q000145:classification / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology; D012171:Retinal Vessels; D014605:Uveitis / Q000209:etiology / Q000473:pathology