title: [Influence of bigumal on the blood coagulation system and on the anticoagulant effect of heparin].
abstract: It was found that in the blood plasma bigumal even at high dose (15 mg/kg) exerted no effect on the parameters of partial thromboplastin and thrombin time but increased the blood plasma tolerance to heparin. Both in buffer medium and blood plasma bigumal effectively decreased the specific effect of heparin. Oral acute (5 mg/kg) and long-term (3 mg/kg daily for 5 days) administration of bigumal to rabbits decreased the time of whole blood coagulation, partial thromboplastin time and reduced the sensitivity of animals to heparin.
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D002727:Proguanil / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D000962:Antimalarials; D006493:Heparin; D002727:Proguanil
vernacular_title: Vliianie bigumalia na sistemu svertyvaniia krovi i antikoaguliantnyĭ éffekt geparina.