title: [Therapy of severe propafenone poisoning--an attempt at elimination by hemoperfusion].
abstract: After suicidal ingestion of 9 g Propafenone, a 31-year-old woman showed unconsciousness, cerebral convulsions, respiratory depression, sinus arrest, ventricular tachycardia and recurrent atrioventricular block. The maximum Propafenone plasma level was 4,702 ng/ml. Only 67.2 mg of Propafenone were eliminated within 4 h of hemoperfusion. Successful therapy could be achieved by symptomatic intensive care treatment. Additionally, 2 X 25 ml of 20%-saline solution were infused. In this case no efficacy of hemoperfusion in the treatment of Propafenone intoxication could be documented.
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000628:therapy; D002851:Chromatography, High Pressure Liquid; D004562:Electrocardiography; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D011405:Propafenone / Q000097:blood / Q000506:poisoning*; D013406:Suicide, Attempted
chemical_list: D011405:Propafenone
vernacular_title: Therapie der schweren Propafenonintoxikation--Eliminationsversuch mittels Hämoperfusion.