title: [Age-related characteristics of thymidine metabolism in healthy subjects and in patients with stomach ulcer and cancer].
abstract: Biosynthesis of pyrimidine nucleotides was intensified in proliferating tissues. Age-dependent alterations in activities of thymidine kinase and thymidine phosphorylase were found in healthy persons of 17-70 years old. Distinct increase in activity of thymidine kinase was observed in patients with gastric ulcer but the activity was decreased with ageing. Alterations in the ratio between anabolic and catabolic reactions involving thymidine were studied also in patients with gastric tumor depending on age.
mesh_terms: D000328:Adult; D000367:Age Factors; D006801:Humans; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000201:enzymology / Q000378:metabolism*; D013276:Stomach Ulcer / Q000201:enzymology / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism*; D013937:Thymidine Kinase / Q000097:blood; D013939:Thymidine Phosphorylase / Q000097:blood
chemical_list: D013939:Thymidine Phosphorylase; D013937:Thymidine Kinase; D013936:Thymidine
vernacular_title: Vozrastnye osobennosti metabolizma timidina v organizme zdorovogo cheloveka, pri iazvennoĭ bolezni i rake zheludka.