The anticoagulant, hepatic lipase-releasing and lipoprotein lipase-releasing activities of several natural and chemically modified heparins differ.
Several 'natural' heparins have been found to have different potencies for releasing hepatic lipase and lipoprotein lipase. These differences can also be obtained by treating heparins with physical and chemical methods, which also affect the anticoagulant activity. These differences in potency in hepatic lipase-releasing activity are discussed in terms of the role of this lipase in lipoprotein and cholesterol metabolism.
D000818:Animals; D000925:Anticoagulants; D006493:Heparin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008049:Lipase / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008970:Molecular Weight; D010084:Oxidation-Reduction; D051381:Rats; D013329:Structure-Activity Relationship; D013552:Swine
D000925:Anticoagulants; D006493:Heparin; D008049:Lipase; D008071:Lipoprotein Lipase