Substituted 2-(2-hydroxyphenyl)benzimidazoles as potential agents for the control of periodontal diseases.
A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.
D000192:Actinomycetales / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001439:Bacteroides / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010510:Periodontal Diseases / Q000188:drug therapy / Q000382:microbiology; D010636:Phenols / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D007202:Indicators and Reagents; D010636:Phenols