title: Lesions of the area postrema and underlying solitary nucleus fail to attenuate the inhibition of feeding produced by systemic injections of cholecystokinin in Syrian hamsters.
abstract: A large body of evidence indicates that the intestinal hormone cholecystokinin (CCK) may serve as a signal for satiety. The abdominal vagus has been shown to be important for the satiety response to exogenous, and by inference, endogenous, CCK in rats and hamsters. Thus, it appears that stimulation of CCK receptors on afferent fibers of the abdominal vagus activates a gut-brain pathway to signal satiety. The present study was undertaken to further trace this viscerosensory pathway by examining food intake after administration of one of two doses (2.0 and 8.0 micrograms/kg) of CCK-octapeptide to intact hamsters and to hamsters sustaining lesions of the area postrema (AP) and underlying nucleus of the solitary tract (NST), regions containing neurons postsynaptic to vagal afferent fibers. As lesions of the AP/NST result in many alterations in ingestive behaviour and body weight regulation in rats, various aspects of feeding and drinking behaviour (spontaneous food intake, body weight maintenance, and responsiveness to a palatable drinking solution and osmotic stimulation) were also examined in lesioned hamsters. Aside from producing transient hypophagia and weight loss immediately after surgery, AP/NST lesions had no effects on these various parameters of ingestive behaviour. The lack of lesion effects on these particular parameters may be explained on the basis that hamsters are generally unresponsive to many of the stimuli for feeding and drinking which purportedly act on the vagus and/or AP/NST. Hamsters with AP/NST lesions were as responsive to the two tested doses of CCK as intact animals.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D005260:Female; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D008647:Mesocricetus; D012462:Saline Solution, Hypertonic; D012844:Sincalide / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D012462:Saline Solution, Hypertonic; D012844:Sincalide