Tin protoporphyrin inhibits carbon monoxide production in suckling mice.
The carbon monoxide excretion rate (VeCO) of groups of 1-day-old mice was measured after administration of two separate doses of 50 nmol of tin protoporphyrin (TP) per gram of body weight. The mean VeCO of the saline-treated control groups over the study period was 1.50 +/- 0.26 nmol/g/h, and that of the TP-treated groups was 1.35 +/- 0.29 nmol/g/h. Tin protoporphyrin treatment reduced the CO excretion by approximately 14% in 2-day-old mice over 24-48 h.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002248:Carbon Monoxide / Q000096:biosynthesis*; D008665:Metalloporphyrins; D051379:Mice; D011166:Porphyrins / Q000494:pharmacology*; D011524:Protoporphyrins / Q000494:pharmacology*
D008665:Metalloporphyrins; D011166:Porphyrins; D011524:Protoporphyrins; D002248:Carbon Monoxide; C032628:tin protoporphyrin IX