Systemic sclerosis-like lesions during long-term penicillamine therapy for Wilson's disease.
Systemic sclerosis-like lesions developed in a 14-year-old boy with Wilson's disease who had been treated with D-penicillamine for 11 years. Clinical and laboratory manifestations included proximal scleroderma, pulmonary restrictive defects, positive antinuclear antibodies, and the deposition of C3 at the dermal-epidermal junction of the lesional skin. This is the first case reported in which long-term administration of penicillamine was followed by the development of systemic sclerosis-like lesions.
D000293:Adolescent; D006527:Hepatolenticular Degeneration / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000473:pathology
D010396:Penicillamine