title: [Tiropramide chlorhydrate in premedication for endoscopic retrograde cholangiopancreatography and its effects on the motor activity of Oddi's sphincter].
abstract: The activity of tiropramide chlorhydrate in the pre-medication for the endoscopical examinations has been evaluated. In particular ERCP has been studied considering as parameters the timing of the different stages of the examination and the activity of Oddi's sphincter. At the end of endoscopy the pressure of the sphincterial region was measured a 3-way miniature catheter. Patients included in the study were divided into two different groups: group A treated with tiropramide chlorhydrate and diazepam vs group B treated only with diazepam. The group with patients pre-medicated with tiropramide chlorhydrate presented a significant reduction in the timing of the different stages of endoscopy. Endoscopy was better tolerated. Manometry showed an antispastic action of the drug without side effects. An important reduction of the degree and duration of the sphincterial phase activity, with a possible improvement of biliary defluxion into the duodenum, was observed.
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000187:drug effects*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010276:Parasympatholytics / Q000494:pharmacology*; D011292:Premedication; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000502:physiology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D010276:Parasympatholytics; D014443:Tyrosine; C031173:tiropramide
vernacular_title: La tiropramide cloridrato nella premedicazione della colangiopancreatografia retrograda endoscopica e suoi effetti sulla attività motoria dello sfintere di Oddi.