The use of ketotifen, a mast cell blocker, for treatment of oligo- and asthenozoospermia.
Treatment of idiopathic oligo- and asthenozoospermia by the mast cell blocker Ketotifen leads to a very moderate, but statistical significant improvement of sperm count and sperm motility. However, pregnancy rate was within the range of spontaneous conceptions. To evaluate the possible significance of this new treatment approach further research is mandatory to elucidate the relationship between mast cell proliferation and dysfunction of the blood-testis barrier.
D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000503:physiopathology; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000166:cytology
D007665:Ketotifen