Synthesis and antitumor activity of N-terminal proline-containing peptide-(chloroethyl)nitrosoureas.
The N alpha-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of H-Pro-Lys(X)-Pro-Val-NH2 (X: tert-butyloxycarbonyl, formyl, (2-chloroethyl)nitrosocarbamoyl) were synthesized. It was found that the bis-substitution of the urea N3 in these derivatives does not decrease the antitumor activity influenced mainly by the nature of the carrier molecule as a whole.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009607:Nitrosourea Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D009607:Nitrosourea Compounds; D011392:Proline