Antiamebic activity of new acridinic derivatives against Naegleria and Acanthamoeba species in vitro.
In vitro antiamebic activity of selected acridine derivatives has been investigated against Naegleria and Acanthamoeba species. The most active compounds belong to the 9-thioacridanone and the 1,2,3,4-tetrahydro-9-thioacridanone series. In addition, some structure-activity relationships are proposed.
D000166:Acridines / Q000494:pharmacology*; D000656:Amoeba / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000166:Acridines