Peritoneal macrophages from mice fed dietary (n-3) polyunsaturated fatty acids secrete low levels of prostaglandins.
Peritoneal macrophages from mice fed diets containing 10% menhaden oil incorporated significant amounts of n-3 polyunsaturated fatty acids (n-3 PUFA) into cellular lipids, and this lowered arachidonic acid in these lipid classes compared to those from mice fed diets containing 10% coconut oil. The n-3 PUFA-enriched macrophages secreted significantly smaller amounts of prostaglandin E, thromboxane B and 6-keto-prostaglandin F1 alpha when stimulated with opsonized zymosan or phorbol myristate acetate. These studies demonstrated that menhaden oil-enriched diets influence fatty acid composition and prostaglandin synthesis in macrophages.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D000074263:Coconut Oil; D004041:Dietary Fats / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism* / Q000494:pharmacology*; D005395:Fish Oils; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D010938:Plant Oils; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010938:Plant Oils; D011453:Prostaglandins; D011458:Prostaglandins E; C033266:Menhaden oil; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D000074263:Coconut Oil