[Physicochemical properties and structure of the nonmacrolide polyene antibiotic altamycin A].
Altamycin A, an antibiotic described earlier was classified by its physicochemical and biological properties as belonging to the subgroup of polyenic nonmacrolides. Physicochemical properties of altamycin A and other representatives of nitrogen-containing polyenic nonmacrolides are presented. It is shown that the molecule of the antibiotic contains D-digitoxose (a sugar). The structure of the antibiotic aglycone was determined by the mass spectra of the oxidative degradation products of perhydroantibiotic, methyl heptahydroantibiotic and methyl permethylperhydroaglycone. Unlike alpha-lipomycin, altamycin A contains the tetraene system of conjugated methylene bonds.
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011090:Polyenes / Q000032:analysis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011090:Polyenes
Fiziko-khimicheskie svoĭstva i struktura nemakrolidnogo polienovogo antibiotika altamitsina A.