Oxalyl thiolesters and N-oxalylcysteine are normal mammalian metabolites.
A method for the quantitative analysis of N-oxalylcysteine and oxalyl thiolesters (RSCOCOO-) in biological samples is described. These compounds were found in all rat tissues examined (kidney, liver, brain, heart, muscle and fat), with the amount of N-oxalylcysteine ranging up to 18 nmoles/g wet weight and that of oxalyl thiolesters up to 65 nmoles/g wet weight. The identification of such compounds in animal tissues adds further credence to the hypothesis that they may be important metabolic effectors.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D003543:Cysteamine / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000378:metabolism; D004952:Esters; D006358:Hot Temperature; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010070:Oxalates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D004952:Esters; D010070:Oxalates; D013438:Sulfhydryl Compounds; C051227:N-oxalylcysteine; D003543:Cysteamine; D003545:Cysteine