Hypertension and renal insufficiency in children with chronic glomerulonephritis.
Ninety five children with chronic glomerulonephritis were studied to analyze the correlation between hypertension and functional deterioration in each of the following histology groups; minor glomerular abnormalities (MGA), proliferative glomerulonephritis (PGN), membrano-proliferative glomerulonephritis (MPGN), membranous glomerulonephritis (MGN) and focal segmental glomerulosclerosis (FSGS). Among the 95 patients, 14 patients revealed to be hypertensive. All patients with MGA and MGN revealed normal blood pressure. There were no statistically significant differences in the prevalence of hypertension in patients with PGN, MPGN and FSGS. The overall incidence of renal insufficiency was significantly higher in the hypertensives (50.0%) than in the normotensives (4.9% p less than 0.0001). The incidences of renal insufficiency were significantly higher in the hypertensives than in the normotensives in patients with PGN (P less than 0.01) and MPGN (P less than 0.05). These data suggest that there is a significant correlation between functional deterioration and hypertension, and that the hypertensive patients with PGN and MPGN are at risk for progression to renal insufficiency.
D000293:Adolescent; D002648:Child; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000473:pathology; D007668:Kidney / Q000503:physiopathology*