[Effect of the blood sera of patients with different pathologies on normal and leukemic cells--the precursors of granulo- and monocytopoiesis].
A study was made of the effect of the blood sera of persons of the control group and patients with various diseases of the blood on normal precursor cells of granulo-monocytopoiesis (CFU-GM) and leukemic clonogenic cells. A stimulating human blood serum effect on proliferation was noted during cultivation of normal CFU-GM and leukemic clonogenic cells in the "agar drop-liquid medium" system. As a rule, the stimulating serum effect manifested itself in the presence of feeder cells or a high "spontaneous" colony formation. Human blood sera can be added to a culture medium for improving its nutritive properties.
D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000187:drug effects*; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007938:Leukemia / Q000097:blood*; D009000:Monocytes / Q000187:drug effects*; D013268:Stimulation, Chemical
D007106:Immune Sera
Vliianie syvorotok krovi bol'nykh s razlichnoĭ patologieĭ na normal'nye i leĭkoznye kletki--predshestvenniki granulomonotsitopoéza.