title: Primary sclerosing cholangitis and pregnancy.
abstract: Primary sclerosing cholangitis is a chronic, fibrosing, inflammatory disorder of unknown etiology affecting the biliary tree. We describe a case of a pregnancy complicated by this condition. Remarkably, maternal cholestasis improved with advancing gestation. Despite a marked elevation of bile acid levels in cord blood, the patient was delivered of a healthy term infant. The principles of management and potential effects of primary sclerosing cholangitis on pregnancy care are discussed.
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000473:pathology* / Q000601:surgery; D002761:Cholangitis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D002792:Cholestyramine Resin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D012598:Sclerosis
chemical_list: D002792:Cholestyramine Resin