[Desferal treatment of aluminum poisoning; effect on serum concentrations of aluminum (Al), iron (Fe) and copper (Cu)].
In 2 patients with a progressive dialysis encephalopathy and increased serum aluminium concentrations a Desferal-treatment with 500 mg per week was performed and in these cases the kinetics of Al, Fe, Cu was investigated. After the application of Desferal an increase of the serum levels, the ultrafiltrable proportion, the dialysance and the eliminated quantity of aluminium developed. In the course of the treatment in the two patients the aluminium level could be reduced to approximately normal values. Nevertheless one patient died of a severe course of a progressive dialysis encephalopathy. An increase of the copper concentration independent of Desferal-treatment after the dialysator passage remained without influence on the course of concentration of the serum copper in the examination period. A remarkable effect of the Desferal-therapy on the iron metabolism could not be established. Since in the dosage used there did not appear any side effects the Desferal-application is to characterized as a distinct and effective technique for the decrease of the serum-aluminium-concentration in patients undergoing dialysis.
D000328:Adult; D000535:Aluminum / Q000097:blood / Q000506:poisoning*; D003300:Copper / Q000097:blood; D003676:Deferoxamine / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood; D007501:Iron / Q000097:blood; D008297:Male; D008657:Metabolic Clearance Rate; D006435:Renal Dialysis
D003300:Copper; D000535:Aluminum; D007501:Iron; D003676:Deferoxamine
Zur Desferalbehandlung der Aluminium-Intoxikation; Einfluss auf die Serumkonzentrationen von Aluminium (Al), Eisen (Fe) und Kupfer (Cu).