Distribution and form of uranium-containing deposits in chickens treated with uranyl nitrate.
The kidneys of chicks treated with uranyl nitrate were examined by electron microscopy. Most deposits of electron-dense material containing uranium were found in the lumina of distal tubules and collecting ducts of kidneys collected 12-24 hours post-treatment. Some deposits were present in extracellular spaces between adjacent cells. Only occasionally were deposits found intracellularly where they were associated with localized cellular degeneration. A generalized cellular degeneration over the whole kidney was seen 72-96 hours post-treatment, but this was not directly associated with the deposits of electron-dense material.
D000818:Animals; D002645:Chickens / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D014018:Tissue Distribution; D014501:Uranium / Q000378:metabolism* / Q000494:pharmacology*; D014502:Uranyl Nitrate / Q000494:pharmacology* / Q000633:toxicity
D014502:Uranyl Nitrate; D014501:Uranium