title: [Electrocardiographic research on broilers and hens following treatment with 1-phenyl-2,3-dimethyl-4-naphthalan morpholinomethylpyrazolinone-5].
abstract: ECG investigations were carried out with the 1-phenyl-2,3-dimethyl-4-naphthalan morpholino methylpyrazolinon-5 compound on broiler birds and hens at single and manifold s/c injection and oral administration. In therapeutic tranquillizing amounts the compound did not lead to ECG changes. It was not until applying several times higher extratherapeutic doses that shortening of the R--R interval occurred along with broadening of the T wave and appearing of sporadic extrasystolic contractions of the chamber No changes in the voltage of the individual ECG peaks were found. Such effects were observed up to the eighth day following treatment. From the 9th up to the 20th day these phenomena gradually disappeared. The frequency of contractions, resp., the contraction capacity of the heart showed no essential changes. On the 21st day after the compound was applied the heart activity came back to normal.
mesh_terms: D000818:Animals; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009025:Morpholines / Q000008:administration & dosage / Q000494:pharmacology*; D047069:Pyrazolones; D013997:Time Factors
chemical_list: D009025:Morpholines; D047069:Pyrazolones; C051366:1-phenyl-2,3-dimethyl-4-naphthalanmorpholinomethylpyrazolin-5-one
vernacular_title: Elektrokardiografski izsledvaniia pri pileta broĭleri i kokoshki sled vŭzdeĭstvie s 1-fenil-2,3-dimetil-4-naftalanmorfolinometilpirazolinon-5.