Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes.
Deoxyuridine (dU) increases chromosome breakage at folic acid (FA)-sensitive common fragile sites (mostly 3p14 and 16q23) in human lymphocytes. This dU-related increase can be suppressed by thymidine or FA. These results suggest that the mechanism of fragile site expression in low FA medium involves misincorporation of dU into DNA.
D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D004247:DNA / Q000378:metabolism; D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D003857:Deoxyuridine / Q000494:pharmacology*; D005492:Folic Acid / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure
D003856:Deoxyuracil Nucleotides; D004247:DNA; D005492:Folic Acid; C007267:2'-deoxyuridylic acid; D003857:Deoxyuridine