The Aplysia FMRFamide gene encodes sequences related to mammalian brain peptides.
We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-amino-acid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.
D000818:Animals; D001048:Aplysia / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D019835:FMRFamide; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009479:Neuropeptides / Q000235:genetics*; D011498:Protein Precursors / Q000235:genetics; D013045:Species Specificity
D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D011498:Protein Precursors; D019835:FMRFamide