[Analysis of decay curves with biphasic kinetics].
Medication of trout and carps with chloramphenicol and sulfadimidine results in tissue residues which best fit by a biexponential decay curve. The analysis of residues does not reveal any systematic deviations of the data from the model. On the basis of this model half lives for the fast and slow drug elimination phases can be estimated. For the assessment of withdrawal times it is necessary to compute confidence limits for the decay curves. A withdrawal time may be defined by the intersection of recommended maximal concentrations with the upper confidence limit. This analysis does not include any metabolites. This model is also suited for monitoring purposes. It is recommended to apply the procedure to all chemicals exhibiting biexponential decay kinetics.
D000818:Animals; D002347:Carps / Q000378:metabolism*; D002701:Chloramphenicol / Q000032:analysis; D003530:Cyprinidae / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008954:Models, Biological; D012487:Salmonidae / Q000378:metabolism*; D013418:Sulfamethazine / Q000032:analysis; D014337:Trout / Q000378:metabolism*
D013418:Sulfamethazine; D002701:Chloramphenicol
Auswertung von Rückstandskurven mit biphasischer Kinetik.