Characterization of the rearranged tpr-met oncogene breakpoint.
We determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. We conclude that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event.
D001483:Base Sequence; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D008769:Methylnitronitrosoguanidine