Pharmacokinetics of theophylline and its metabolites in rabbits.
The pharmacokinetics of theophylline (1,3-DMX) and its metabolites were investigated in detail in four male rabbits after bolus intravenous injection (12 mg/kg) of the compound. Theophylline was measured in blood and urine, and its metabolites were determined only in urine. Apparent first-order rate constants for the metabolic processes involved in the formation of 1,3-DMX metabolites and their excretion in urine were calculated. An appropriate 13-compartment model was formulated to describe the disposition of 1,3-DMX and its metabolites.
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013806:Theophylline / Q000378:metabolism* / Q000652:urine
D013806:Theophylline