Effects of dexamethasone phosphate on the formation of ester forms of riboflavin in the lens.
We investigated the effects of excess administration of dexamethasone phosphate (Dx) on the synthesis of ester forms of riboflavin in the rat lens. The formation of ester forms of riboflavin in the lens was reduced by intraperitoneal administration of Dx. No effects on the synthesis were noted upon the administration of a single dose of Dx. Our results show that phosphorylation of riboflavin in the lens is reduced under the condition of excess administration of Dx.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002386:Cataract / Q000139:chemically induced; D003907:Dexamethasone / Q000633:toxicity*; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D012256:Riboflavin / Q000378:metabolism*
D002352:Carrier Proteins; C027091:cortisol binding globulin; D003907:Dexamethasone; D012256:Riboflavin