title: Effects of early postnatal gonadal steroids on the successive conditional discrimination reversal learning in the rat.
abstract: In the present study the existence of sex differences in the acquisition, retraining and reversal of a successive conditional discrimination learning (Experiment 1) and the role of the early postnatal gonadal steroids on these discrimination tasks (Experiment 2) were investigated. In Experiment 1 two groups of experimentally naive rats (males and females) were exposed to a black-white successive conditional discrimination task in a T-maze. No sex differences were found in the acquisition or retraining. However, in the reversal phase females made fewer errors and reached the discrimination criterion (90% of correct choices) sooner than males. In Experiment 2, the absence of sex differences in the acquisition or retraining phases and the existence of sexual dimorphism in the reversal period were confirmed. In addition, female androgenization and male orchidectomy, on day one after birth, reversed the direction of the sex differences found in the successive conditional discrimination reversal learning.
mesh_terms: D000728:Androgens / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008297:Male; D009919:Orchiectomy; D051381:Rats; D012727:Sex Characteristics; D013739:Testosterone / Q000494:pharmacology
chemical_list: D000728:Androgens; D013739:Testosterone