Stimulation of Schistosoma mansoni miracidia by a 80 kDa glycoprotein from Biomphalaria glabrata.
Soluble extracts of Biomphalaria glabrata stimulate in vitro incorporation of methionine in Schistosoma mansoni miracidia. Evidence is presented that a unique 80 kDa glycoprotein representing less than 0.01% of total snail proteins and uniformly distributed in the snail body, is responsible for the observed stimulation. This protein specifically acts on the miracidia and this observation suggests that this glycoprotein influences snail penetration and development of miracidia. However, the presence of molecules stimulating S. mansoni miracidia was also demonstrated in S. mansoni nonpermissive molluscs.
D000818:Animals; D001700:Biomphalaria / Q000469:parasitology* / Q000502:physiology; D006023:Glycoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D006790:Host-Parasite Interactions; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D006023:Glycoproteins; D008715:Methionine