Reduction in paradoxical sleep after L-dopa administration in rats.
The EEG and EMG activity of two groups of rats (N = 8 each) was recorded during one experimental and 5 control days. On the experimental day, one group received 125.0 mg/kg L-dopa preceded by 50.0 mg/kg benserazide hydrochloride. The other group received 1.0 mg/kg haloperidol, immediately before the recording session. After L-dopa plus benserazide administration the total time and the number of episodes of paradoxical sleep and slow wave sleep decreased significantly compared to control sessions.
D000818:Animals; D001545:Benserazide / Q000494:pharmacology; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
D011954:Receptors, Dopamine; D007980:Levodopa; D001545:Benserazide; D006220:Haloperidol