Prevention of Clostridium difficile induced mortality in gnotobiotic mice by Saccharomyces boulardii.
Oral preventive treatment of gnotobiotic mice by Saccharomyces boulardii significantly decreased mortality following Clostridium difficile infection. A single S. boulardii ingestion protected 16% of mice, whereas 56% were protected when S. boulardii was given continuously in the drinking water. No direct antagonistic effect of the yeast on C. difficile numbers was detected, whereas a modulation of fecal cytotoxin production was demonstrated.
D000818:Animals; D000898:Antibiosis; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000096:biosynthesis; D003013:Clostridium / Q000254:growth & development / Q000378:metabolism; D003015:Clostridium Infections / Q000628:therapy*; D005856:Germ-Free Life; D051379:Mice; D012440:Saccharomyces / Q000254:growth & development*
D001426:Bacterial Proteins; D001427:Bacterial Toxins; C031815:toxB protein, Clostridium difficile