On the dose equivalence of flurazepam and triazolam.
Flurazepam (30 mg), triazolam (0.5 mg) and placebo were given in the morning to 6 normal volunteers in a double-blind crossover study. Subjects were evaluated by a large battery of psychophysiological tests before and 1 and 5 hours after drug administration. Triazolam was significantly more sedative than flurazepam and both were significantly different from placebo. Slope-ratio assay analysis of the results from the present study pooled with those from a similar previous study (C. Gorenstein and V. Gentil, Psychopharmacology, 80: 376-379, 1983) indicated that these doses are non-equivalent. We suggest that dose-equivalence studies based on the present method should be carried out early in the development of new hypnotic drugs.
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography; D005479:Flurazepam / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D009042:Motivation / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D011581:Psychological Tests; D012890:Sleep / Q000187:drug effects; D013810:Therapeutic Equivalency; D014229:Triazolam / Q000008:administration & dosage*
D014229:Triazolam; D005479:Flurazepam