Release of thromboxane B2 and leukotriene C4 and reduction in renal perfusion in experimental anaphylactic reaction of isolated guinea pig kidney.
Isolated, perfused kidneys from ovalbumin-sensitized guinea pigs released large amounts of histamine, thromboxane (TX) B2 and less consistently leukotriene (LT) C4, and showed a marked reduction in perfusion rate (PR) following injection of the specific antigen, or antiserum to IgG1 and IgG2; both types of anaphylactic reaction being due to cross-linking of mast cell-sensitizing immunoglobulin. Infusion of low concentration of synthetic LTC4 caused reduction in PR, which was blocked by the antagonist FPL 55712. Large-dose bolus injections of histamine also reduced PR. It is concluded that the kidney is a target organ in anaphylaxis and that the reaction alters renal haemodynamics.
D000707:Anaphylaxis / Q000209:etiology*; D000818:Animals; D006168:Guinea Pigs; D007668:Kidney / Q000276:immunology*; D010477:Perfusion; D013189:SRS-A / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism*
D013189:SRS-A; D013929:Thromboxane B2