A new synthetic route to 2- and 4-methoxyestradiols by nucleophilic substitution.
A new snythetic route to 2- and 4-methoxyestradiols is described. Benzo-15-crown-5 with CuI catalyzes the specific nucleophilic substitution at the carbon atom carrying a non-activated halogen on ring A of the estradiol.
D000077584:2-Methoxyestradiol; D055598:Chemical Phenomena; D002621:Chemistry; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis
C045018:4-methoxyestradiol; D004958:Estradiol; D000077584:2-Methoxyestradiol