title: Iron, a new aid in the treatment of Parkinson patients.
abstract: One of the problems in treating Parkinson patients is the so called "off-effect" which occurs after long term treatment with L-DOPA. Off-effects are characterized by severe rigor and akinesia. Increasing dosages of L-DOPA and decarboxylase- or monoaminooxidase-inhibitors do not improve these symptoms. Intravenously applied iron--in form of a ferri-ferro-complex--exhibited a considerable benefit for all patients treated so far. They regained a remarkable mobility. Their disability score dropped from up to 90% down to 30%. The effect of iron is dosage-dependent and lasts 24 to 48 hours.
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D007501:Iron / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy*
chemical_list: D000978:Antiparkinson Agents; D007501:Iron