title: Systemic anaphylaxis due to an oxidation product of p-phenylenediamine in a hair dye.
abstract: An anaphylactic reaction to a hair dye is reported. Skin testing with the dye and its individual components demonstrated a wheal and flare response to an oxidation product of p-phenylenediamine. This product is N'N'-bis-(4-aminophenyl)-2,5-diamino-1,4-quinonediimine. Passive transfer of this sensitivity by the patient's serum to a normal control implicated an IgE-mediated reaction.
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D005260:Female; D006202:Hair Dyes / Q000009:adverse effects*; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007428:Intradermal Tests; D008875:Middle Aged; D010655:Phenylenediamines / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D006202:Hair Dyes; D006203:Hair Preparations; D010655:Phenylenediamines; C051597:Bandrowski's base; D007073:Immunoglobulin E