title: [Pharmacokinetics of cefazolin during hemosorption and hemodialysis].
abstract: The influence of hemosorption and hemodialysis on the pharmacokinetics of cefazolin was studied in 20 patients with chronic and acute renal insufficiency. The integral mean value of the antibiotic extraction coefficient in hemosorption was approximately 2 times higher than that in hemodialysis. In the first case the value of this parameter systematically lowered with time (the constant of the process rate amounted to 0.89 h-1), while in the second case it was constant.
mesh_terms: D002437:Cefazolin / Q000097:blood* / Q000627:therapeutic use; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D007700:Kinetics; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D002437:Cefazolin
vernacular_title: Farmakokinetika tsefazolina pri gemosorbtsii i gemodializa.