Increased chloride efflux in fibroblasts from X-linked muscular dystrophies and clones from Duchenne carriers.
Previous studies have suggested an increased chloride membrane permeability in Duchenne muscular dystrophy (DMD) fibroblasts. We report that an increased chloride efflux with respect to controls is present not only in fibroblasts from DMD, but also from two other X-linked muscular dystrophies, Becker and Emery-Dreifuss, as well as in clones from DMD carrier females. The latter observation suggests that, at least in DMD, the increased chloride efflux phenotype might be subject to lyonization.
D002478:Cells, Cultured; D002712:Chlorides / Q000378:metabolism*; D002999:Clone Cells; D005347:Fibroblasts / Q000378:metabolism; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D009136:Muscular Dystrophies / Q000235:genetics* / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D014960:X Chromosome
D002712:Chlorides