[Effect of a calcium channel blocker on the hypophyseal secretion of luteinizing hormone in intact and castrated rats of both sexes].
The effect of verapamil on luteinizing hormone secretion by pituitary body was studied in normal and castrated male and female rats. Intragastric verapamil administration at a dose of 10 mg/g body weight two hours prior to decapitation decreased luteinizing hormone serum and pituitary levels in female rats only in proestrus. It is suggested that preovulatory luteinizing hormone secretion depends partially on estradiol-stimulated calcium transport.
D000818:Animals; D005260:Female; D007986:Luteinizing Hormone / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D010902:Pituitary Gland / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D013737:Testis / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology*
D007986:Luteinizing Hormone; D014700:Verapamil
Vliianie blokatora kal'tsievykh kanalov na sekretsiiu liuteiniziruiushchego gormona gipofizom u intaktnykh i kastrirovannykh krys oboego pola.