Mutagenicity of the C-nitroso analog of fenitrothion.
The chemicals fenitrothion, nitroso fenitrothion, amino fenitrothion and 3-methyl-4-nitrophenol were tested for mutagenicity to Salmonella typhimurium strains TA98 and TA100, both in the presence and absence of rat liver S-9 mix. The strong mutagenicity of nitroso fenitrothion to both strains either in the presence or absence of S-9 mix contrasted with the observation that fenitrothion displayed no mutagenicity in these tester strains. The results suggest that the normal nitroreductases present in TA98 and TA100 cannot metabolize fenitrothion to a mutagenic metabolite. This inability of the tester strains to effect partial nitroreduction results in the failure of this screening system to predict the potential genotoxicity of this pesticide.
D000818:Animals; D003408:Cresols / Q000494:pharmacology; D005278:Fenitrothion / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats
D003408:Cresols; D009153:Mutagens; C051557:4-aminofenitrothion; C008636:4-nitro-3-cresol; C051558:4-nitrosofenitrothion; D005278:Fenitrothion