Effects of angiotensin II on the acquisition of conditioned avoidance response in alcohol-dependent rats.
The effect of angiotensin II (ANG II), given in a single intraventricular dose (2 micrograms ivc), on the course of acquisition of a conditioned avoidance response was studied in rats pretreated with alcohol. Ethanol administered for 6 or 18 days did not affect the acquisition, while a prolonged administration (for 2 months) markedly depressed the ability to learn. This effect was not only reversed by ANG II, but the peptide significantly elevated the acquisition rate above the control value.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D051381:Rats; D011919:Rats, Inbred Strains; D019966:Substance-Related Disorders / Q000523:psychology*; D013997:Time Factors
D000804:Angiotensin II; D000431:Ethanol