Quantitation of hexaprazol in human plasma and urine by capillary gas chromatography with nitrogen-sensitive detection.
A selective and sensitive gas chromatographic assay for hexaprazol, a new antiulcer drug, in human plasma and urine has been developed. The method involves liquid-liquid extraction and capillary gas chromatography with nitrogen-sensitive detection. The limit of quantitation of plasma hexaprazol is ca. 25 ng/ml. The assay procedure permits the measurement of the levels of the unchanged drug following its clinical administration to humans.
D000284:Administration, Oral; D000897:Anti-Ulcer Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D002849:Chromatography, Gas; D006801:Humans; D007275:Injections, Intravenous; D010879:Piperazines / Q000032:analysis* / Q000097:blood / Q000652:urine
D000897:Anti-Ulcer Agents; D010879:Piperazines; C042123:esaprazole