title: Threshold for behavioral response to testosterone in old castrated male rhesus macaques.
abstract: The sexual behaviors of old, intact (N = 5) and old, castrated (N = 6) rhesus macaque males were compared in six series of pair tests with receptive females. The castrated monkeys were tested when untreated and when given five doses of testosterone propionate (TP; 0.004, 0.016, 0.064, 0.256, and 1.024 mg/kg of body weight) in consecutive months. The serum testosterone (T) level was determined for each male before and after each series of tests. When untreated, none of the castrated males ejaculated, and yawning was significantly less in these monkeys than in intact males-no other behavioral measures differed significantly. Within 2 weeks of daily injections of 0.004 mg of TP/kg, two males ejaculated, and all differences in measures of ejaculation were eliminated. A third male ejaculated after 1 week of treatment with 0.016 mg of TP/kg. Yawning values did not differ during and after treatment with 0.064 mg of TP/kg. Although final mean serum T levels were six times higher in castrated (24.3 ng/ml) than in intact males (4.2 ng/ml), sexual performance levels did not exceed those of intact males.
mesh_terms: D000375:Aging; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008251:Macaca / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone