title: An increase in water content of mouse erythrocytes infected with Plasmodium yoelii.
abstract: Mean cell volume and mean cell water content were examined in Plasmodium yoelii-infected mouse erythrocytes by gas chromatography and 3H-sucrose. Mean cell volume increased by 16% in infected erythrocytes with late trophozoites and schizonts. Mean cell water content further increased by 23% in the infected erythrocytes. Measurement of the erythrocyte potassium and sodium concentrations by an atomic absorption spectrophotometer revealed that the infected erythrocytes contained highly elevated sodium and slightly reduced potassium levels when calculated per single erythrocyte. It is suggested that membrane transport processes of sodium and potassium are changed in P. yoelii-infected erythrocytes and that a passive inflow of sodium takes place, which results in an increase in intra-erythrocytic water content.
mesh_terms: D000818:Animals; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D010961:Plasmodium; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water; D012964:Sodium; D011188:Potassium