[Mechanisms of the radiation-induced disorder of DNA synthesis. The correlation of biosynthesis, DNA repair and DNA polymerase alpha and beta activity in the bone marrow of rats exposed to gamma quanta and fast neutrons].
A study was made of DNA biosynthesis and repair and alpha- and beta-DNA-polymerase activity in rat bone marrow during the first 24 hours following whole-body irradiation with gamma-quanta and fast neutrons (up to 6 Gy). There was a correlation between the post-irradiation inhibition of DNA biosynthesis, a decrease in DNA-polymerase activity and template reparability. The data obtained permitted to consider the radiation-induced disturbance of DNA biosynthesis and the change in beta-polymerase activity as one of the possible mechanisms of formation of high relative biological effectiveness of neutrons.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004249:DNA Damage; D004256:DNA Polymerase I / Q000528:radiation effects*; D004257:DNA Polymerase II / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000528:radiation effects; D005214:Fast Neutrons; D005260:Female; D005720:Gamma Rays; D008297:Male; D009502:Neutrons; D051381:Rats; D011919:Rats, Inbred Strains; D012062:Relative Biological Effectiveness; D013997:Time Factors
D004277:DNA, Single-Stranded; D004247:DNA; D004256:DNA Polymerase I; D004257:DNA Polymerase II
Mekhanizmy radiatsionnogo narusheniia biosinteza DNK. Sootnoshenie biosinteza, reparatsii DNK i aktivnosti DNK-polimeraz al'fa i beta v kostnom mozge u krys pri deĭstvii gamma-kvantov i bystrykh neĭtronov.