title: Inferior olive lesion induces long-term modifications of cerebellar inhibition on Deiters nuclei.
abstract: The frequency of discharge of cerebellar Purkinje cells and lateral vestibular nuclear cells were recorded at different intervals of time after injection of 3-acetylpyridine (3AP), which destroys the inferior olivary nucleus. During the first few days, Purkinje cells showed an increase of simple spike firing, while Deiters cells showed a strong depression of their discharge. Recordings up to 3 months demonstrated, for both groups of cells, a recovery, whose time course is faster for Deiters cells than for Purkinje cells. A reduced inhibitory efficacy of Purkinje cells, as a consequence of climbing fibre deprivation, is suggested.
mesh_terms: D000818:Animals; D009412:Nerve Fibers / Q000502:physiology; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014726:Vestibular Nuclei / Q000502:physiology*; D003689:Vestibular Nucleus, Lateral / Q000502:physiology*