Effect of age on homovanillic and 4-hydroxy-3-methoxymandelic acid levels in plasma.
The plasma levels of homovanillic and 4-hydroxy-3-methoxymandelic acids have been determined in 524 normal subjects ranging from birth to 49 years of age using a mass fragmentographic method. The mean concentration of homovanillic acid in plasma declines exponentially from the age of 1 day (X = 2342.0 nmol/l, 426.6 ng/ml) to adulthood (X = 60 nmol/l, 10.9 ng/ml). 4-Hydroxy-3-methoxymandelic acid behaves in a similar although not so extreme manner (392 nmol/l, 77.6 ng/ml-50 nmol/l, 10 ng/ml).
D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005312:Fetal Blood / Q000032:analysis; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D014642:Vanilmandelic Acid / Q000097:blood*
D014642:Vanilmandelic Acid; D006719:Homovanillic Acid