Estrogen receptor in dissociated and cultured human breast fibroadenoma epithelial cells.
Estrogen binding was measured by a whole cell receptor assay in epithelial cells isolated from 20 premenopausal patients with breast fibroadenomas. A high affinity specific binding for estrogens was detected in the epithelial cells isolated from all 20 fibroadenomas. A relationship between estrogen binding and the phase in the menstrual cycle of the patient has been observed. Cell culture experiments using serum-free medium have also shown that estrogen binding can be augmented by cortisol.
D000232:Adenofibroma / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis*; D002478:Cells, Cultured; D004848:Epithelium / Q000032:analysis; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D008597:Menstrual Cycle; D011960:Receptors, Estrogen / Q000032:analysis* / Q000187:drug effects
D011960:Receptors, Estrogen; D006854:Hydrocortisone