Potential acetylcholinesterase reactivators: pyridine and alpha-oxooxime derivatives.
The synthesis and pharmacological screening in vitro and in vivo of pyridine-2-carbaldoxime derivatives I and alpha-oxooximes II are described. Four compounds elicited reactivating effect on phosphorylated acetylcholinesterase comparable with that of pralidoxime used as reference substance. Among the compounds tested, interesting structures are those of oximes bearing a thioether substituent [RA 49 (Table 1) and RA 59 (Table 2)] chloro derivative of MINA [RA 55 (Table 2)] and dipyridyl glyoxime methiodide RA 56 (Table 1).
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D001921:Brain / Q000201:enzymology; D055598:Chemical Phenomena; D002621:Chemistry; D002801:Cholinesterase Reactivators / Q000138:chemical synthesis* / Q000633:toxicity; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011220:Pralidoxime Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D002801:Cholinesterase Reactivators; D010091:Oximes; D011220:Pralidoxime Compounds; D011725:Pyridines; D000110:Acetylcholinesterase