Radiation-induced neoplasms of the brain.
The histopathology of two patients with radiation-induced neoplasms of the brain following therapeutic irradiation for intracranial malignancies is described. The second neoplasms were an atypical meningioma and a polymorphous cell sarcoma, respectively. They occurred 12 and 23 years after irradiation (4000 rad), within the original field of irradiation. In both cases, the radiation-induced tumors were histologically distinct from the initial medulloblastomas. Both patients were retreated with local irradiation using permanent implantation of radioactive iodine-125 seeds.
D000328:Adult; D001918:Brachytherapy; D001932:Brain Neoplasms / Q000628:therapy*; D002528:Cerebellar Neoplasms / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D002648:Child; D003399:Craniotomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D008579:Meningioma / Q000628:therapy*; D009381:Neoplasms, Radiation-Induced / Q000628:therapy*; D012086:Reoperation; D014057:Tomography, X-Ray Computed