Recurrent reversible acute renal failure from amphotericin.
A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effective arterial volume, may activate tubuloglomerular feedback, thereby contributing to acute renal failure.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000666:Amphotericin B / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006501:Hepatic Encephalopathy / Q000150:complications; D006801:Humans; D008297:Male; D012131:Respiratory Insufficiency / Q000150:complications; D013174:Sporotrichosis / Q000150:complications / Q000188:drug therapy*
D000666:Amphotericin B; D003404:Creatinine