[Microcirculation of tumors and adjacent tissues during combined exposure to metronidazole and hyperthermia].
The results of the study have shown that the proposed temperature-exposure regimen (42-43 degrees C for 30 min.) 30-40 min after metronidazole administration (1 mg per 1 g of the body mass of an animal) influences the vascularization of both normal tissues of the hip and tumors though to a lesser degree. It manifests itself in a elevation of the tone resulting in hypovascularization and a decrease in the total diameter of the vessels. This reaction is more pronounced in the first hours of the first day. The vascular system of ovarian adenocarcinoma turned out to be more reactive as compared to sarcoma 45.
D000230:Adenocarcinoma / Q000098:blood supply* / Q000188:drug therapy / Q000532:radiotherapy; D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D006979:Hyperthermia, Induced; D008795:Metronidazole / Q000627:therapeutic use*; D008833:Microcirculation / Q000187:drug effects / Q000528:radiation effects; D008852:Microradiography; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000532:radiotherapy; D051381:Rats; D012513:Sarcoma, Experimental / Q000098:blood supply* / Q000188:drug therapy / Q000532:radiotherapy; D013997:Time Factors
D008795:Metronidazole
Mikrotsirkuliatsiia opukholi i prilezhashchikh tkaneĭ pri sochetannom vozdeĭstvii metronidazola i gipertermii.