title: Chiral and achiral phosphorothioate analogs of 2-5A: enzymatic synthesis, characterization, and biological activities.
mesh_terms: D000227:Adenine Nucleotides / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001667:Binding, Competitive; D002474:Cell-Free System; D055598:Chemical Phenomena; D002621:Chemistry; D004722:Endoribonucleases / Q000378:metabolism; D006801:Humans; D009843:Oligoribonucleotides / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology*; D063086:Organothiophosphates / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D014176:Protein Biosynthesis; D013237:Stereoisomerism
chemical_list: D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; C023505:2',5'-oligoadenylate; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease