The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer--poloxamine 908.
Colloidal carriers injected intravenously are normally removed rapidly and efficiently by the liver and this represents a major barrier to drug targeting. By coating model microspheres and emulsions with a block co-polymer (poloxamine) it has been possible to keep the carrier circulating in the vascular compartment with little or no uptake by the reticuloendothelial system.
D000818:Animals; D003102:Colloids; D005029:Ethylenediamines; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008863:Microspheres; D009206:Myocardium / Q000378:metabolism; D011060:Poloxalene / Q000378:metabolism; D011092:Polyethylene Glycols; D011108:Polymers / Q000378:metabolism*; D011137:Polystyrenes / Q000378:metabolism*; D011817:Rabbits; D013154:Spleen / Q000378:metabolism*
D003102:Colloids; D005029:Ethylenediamines; D011108:Polymers; D011137:Polystyrenes; C012571:tetronic 701; D011092:Polyethylene Glycols; D011060:Poloxalene