[Radiosensitizing and toxic action of metronidazole and isometronidazole (1-(2-hydroxyethyl)-2-methyl-4-nitroimidazole) on the cells of Ehrlich ascites cancer and hemoblastosis La in vitro].
A study was made of Ehrlich ascites tumor growth and life span of mice bearing hemoblastosis La after inoculation of tumor cells subjected, in anaerobic conditions, to the effect of gamma-radiation and/or metronidazole and isometronidazole. It was shown that the cytotoxic effect of isometronidazole was less manifest than that of metronidazole the radiosensitizing effect, with a reference to anoxic tumor cells in vitro, being nearly the same.
D000693:Anaerobiosis / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D007942:Leukemia, Experimental / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use* / Q000633:toxicity; D013997:Time Factors
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; C031624:isometronidazole
Radiosensibiliziruiushchee i toksicheskoe deĭstvie metronidazola i izometronidazola [1-(2-gidroksiétil)-2-metil-4-nitroimidazol] na kletki astsitnogo raka Erlikha i gemoblastoza La in vitro.