Ultrastructural abnormalities of the liver in total lipodystrophy.
We present the results of light and electron microscopy studies of the liver in an 8-year-old girl with congenital total lipodystrophy. Liver histology revealed cirrhosis, and ultrastructural study showed mitochondrial abnormalities and an increase in the number of peroxisomes. A potential relationship between the high fatty acid concentration in the serum and the peroxisomal proliferation is considered.
D002648:Child; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000151:congenital / Q000473:pathology*; D008099:Liver / Q000648:ultrastructure*; D008830:Microbodies / Q000648:ultrastructure; D008854:Microscopy, Electron