Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs?
In the anaesthetized rat the intravenous injection of 5-HT antagonists, cinanserin and methysergide, induces in two-thirds of neurones studied, an increase in the responsiveness of dorsal horn convergent neurones to C-fibre stimulation. These results are in favour of the existence of serotonergic tonic descending inhibitory effects on the spinal transmission of noxious messages.
D000818:Animals; D002928:Cinanserin / Q000494:pharmacology; D004558:Electric Stimulation; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*
D012702:Serotonin Antagonists; D012701:Serotonin; D002928:Cinanserin; D008784:Methysergide