title: Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours.
abstract: Chronically hypoxic cells in solid tumours are reported to be more slowly proliferating than aerobic cells situated closer to blood vessels. Cycle-active drugs such as 5-fluorouracil (5-FU) might be expected to have greater activity against rapidly proliferating aerobic cells. The effect of 5-FU was therefore assessed against aerobic and hypoxic cells in murine tumours; this was done by giving the drug alone or 1 h before irradiation of the tumour under aerobic or hypoxic conditions. Aerobic and hypoxic cells appeared to have equal sensitivity to 5-FU in the KHT and 16/C tumours, and the effect of a single dose of 5-FU was additive to that of radiation.
mesh_terms: D000332:Aerobiosis; D000818:Animals; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D010100:Oxygen / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy
chemical_list: D010100:Oxygen; D005472:Fluorouracil; D008727:Methotrexate