Modulatory effects of Streptococcus mutans on human neutrophil adherence and deoxyglucose uptake.
Suppression of human neutrophil adherence and deoxyglucose uptake was observed after direct interaction between neutrophils and serotype c of Streptococcus mutans, but not other serotypes. Since neutrophils comprise more than 95% of leukocytes in gingival crevicular fluid and constitute one of the first lines of defense in the oral cavity, the capacity of S. mutans serotype c to suppress neutrophil activation may explain its predominance over other serotypes, and its greater propensity for colonization of the oral cavity.
D002448:Cell Adhesion; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D005557:Formaldehyde / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000166:cytology / Q000382:microbiology*; D013295:Streptococcus mutans / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D003837:Deoxy Sugars; D005557:Formaldehyde; D003847:Deoxyglucose