Penicillamine associated pulmonary hemorrhage.
Penicillamine is the drug of choice in Wilson's disease and a therapeutic alternative in rheumatoid arthritis. Autoimmune complications associated with penicillamine include cases resembling systemic lupus erythematosus and Goodpasture's syndrome. We report a case of diffuse pulmonary hemorrhage associated with prolonged penicillamine use in a patient with Wilson's disease with evidence of circulating immune complexes and complement activation, but without serologic or morphologic evidence of systemic lupus erythematosus, Goodpasture's syndrome or renal disease.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000276:immunology; D006470:Hemorrhage / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008297:Male; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D010396:Penicillamine