title: Inhibitory effects of intravenous chloramphenicol sodium succinate on the disposition of phenylbutazone in horses.
abstract: The effects of i.v. chloramphenicol sodium succinate on the pharmacokinetics of i.v. phenylbutazone in six healthy adult horses were investigated. Administration of chloramphenicol sodium succinate to mares reduced mean (+/- SD) phenylbutazone clearance from 0.600 +/- 0.222 to 0.339 +/- 0.123 ml/min per kg and increased mean (+/- SD) half life from 244 +/- 59.8 to 371 +/- 80.8 min and mean residence time from 333 +/- 86.2 to 533 +/- 124 min. The mean steady-state volume of distribution of phenylbutazone was unchanged, with mean (+/- SD) values of 187 +/- 28.9 ml/kg in control animals and 170 +/- 32.4 ml/kg after chloramphenicol sodium succinate.
mesh_terms: D000818:Animals; D001682:Biological Availability; D002701:Chloramphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006736:Horses / Q000378:metabolism*; D007275:Injections, Intravenous; D010113:Oxyphenbutazone / Q000097:blood; D010653:Phenylbutazone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors
chemical_list: D002701:Chloramphenicol; D010653:Phenylbutazone; D010113:Oxyphenbutazone; C026016:chloramphenicol succinate