[Occurrence of phenylalanine hydroxylase in the human kidney].
Phenylalanine hydroxylase activity, determined by fluorimetric procedure in human kidney (cortex) of 17 patients, who had a kidney operation, was on the average 4.7 nkat tyr/g protein (25 degrees C), which is 28% in comparison to the enzyme activity in human liver. This is in good accordance with the results of AYLING et al. who investigated 15 human kidneys. They found by the spectrophotometric method 22% of the liver enzyme activity. A nonspecific hydroxylation could be excluded by tests with the inhibitors p-Cl-phenylalanine, 3-I-tyrosine and 6-F-tryptophan.
D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000201:enzymology / Q000601:surgery; D007672:Kidney Cortex / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology / Q000601:surgery; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D010651:Phenylalanine Hydroxylase / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity
D010651:Phenylalanine Hydroxylase
Zum Vorkommen der Phenylalaninhydroxylase in menschlicher Niere.