title: Effects of benfluorex on sterol biosynthesis in incubated human blood mononuclear cells.
abstract: The hypocholesterolaemic drug Benfluorex has been shown to inhibit the rate of sterol synthesis in rat hepatocytes. At present no data on a similar effect in human cells are available. The results of the present study demonstrate that Benfluorex has an inhibitory activity on the incorporation of 14C-acetate and of 14C-HMG-CoA into non-saponifiable lipids in human blood mononuclear cells incubated in lipid-deficient medium. The lack of effect on the incorporation of 14C-mevalonate into non-saponifiable lipids strongly suggests that the reduction of sterol biosynthesis is mainly due to the inhibition of HMG-CoA reductase activity.
mesh_terms: D001773:Blood Cells / Q000187:drug effects* / Q000378:metabolism; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008798:Mevalonic Acid / Q000097:blood; D013261:Sterols / Q000096:biosynthesis* / Q000097:blood
chemical_list: D013261:Sterols; D005277:Fenfluramine; C001584:benfluorex; D008798:Mevalonic Acid