Gas chromatographic evaluation of the antimycotic democonazole for pharmacokinetic and bioavailability studies in man and animals.
A new gas chromatographic method for quantitative determination of 1-[2,4-dichloro-beta-[2-(p-chlorophenoxy)ethoxy] styryl]imidazole (demonoconazole), employing an electron capture detector, was developed. All analytical parameters were satisfactory within the range between 5 ng and 1 micrograms per ml of plasma, which means 20 pg-2 ng as absolute sensitivity. This method therefore is specific and sensitive enough for the quantitative determination of the drug in biological samples for pharmacokinetic and bioavailability studies to be performed in animals and human beings.
D000818:Animals; D000935:Antifungal Agents / Q000097:blood / Q000378:metabolism*; D001682:Biological Availability; D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D007093:Imidazoles / Q000097:blood*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000935:Antifungal Agents; D007093:Imidazoles; C050975:democonazole