The effect of intrarenal nickel subsulfide injections upon the activity of selected erythrocyte and bone marrow enzymes in rats.
The experiments were carried out on Wistar rats. The animals were divided into five groups: Group 1: control group; Group 2: the animals received a single intrarenal dose of nickel subsulfide (Ni3S2) in saline; Group 3: the animals receiving a single intrarenal dose of saline; Group 4: the animals receiving a single intrarenal dose of Ag2S in saline; Group 5: the animals receiving a single intrarenal dose of activated charcoal in saline. Prior to the procedure peripheral blood indices were determined. The experiments included animals manifesting polycythemia. Samples of blood and bone marrow were collected and the activities of AchE, GR and G6PD were determined. An increase in the activity of the three studied enzymes was detected in Groups no. 2 and 5.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001769:Blood / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007267:Injections; D007668:Kidney; D008297:Male; D009532:Nickel / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D009532:Nickel; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D000110:Acetylcholinesterase; C017557:nickel subsulfide