Trimoprostil decreases acid disappearance from the human stomach.
A double-blind, placebo-controlled, randomized crossover study involving 8 healthy volunteers was carried out to investigate the disposal of an acid load instilled into the stomach after oral administration of two doses of trimoprostil (0.125 and 1.5 mg). The results showed that trimoprostil reduced the disappearance of acid from the gastric lumen but did not influence the rate of gastric emptying of acid.
D000328:Adult; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006851:Hydrochloric Acid / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011897:Random Allocation
D011459:Prostaglandins E, Synthetic; C038879:trimoprostil; D015232:Dinoprostone; D006851:Hydrochloric Acid