title: Arginine sensors in the hepato-portal system and their reflex effects on pancreatic efferents in the rat.
abstract: To investigate the possible existence of arginine sensors in the liver and their reflex effects, afferent discharges from the hepatic branch of the vagus nerve and efferent discharges from the pancreatic branches of the splanchnic and vagus nerves were recorded. Intraportal injection of arginine increased afferent discharge rate of the hepatic branch of the vagus nerve, slightly depressed the efferent discharge rate of the pancreatic vagal branch, and increased the efferent discharge rate of the pancreatic splanchnic branch. The results suggest the existence of arginine sensors in the hepato-portal system that exert reflex regulation of the pancreatic neuroendocrine system.
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002628:Chemoreceptor Cells / Q000502:physiology*; D008099:Liver / Q000294:innervation*; D008297:Male; D009476:Neurons, Efferent / Q000502:physiology; D010179:Pancreas / Q000294:innervation*; D011168:Portal System / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology*; D013153:Splanchnic Nerves / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D001120:Arginine