Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment.
The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photoaddition. This test allows a rapid genetic classification of FA patients which appears to be a prerequisite for investigations of the biochemical defect(s) in FA.
D000741:Anemia, Aplastic / Q000235:genetics*; D002478:Cells, Cultured; D003432:Cross-Linking Reagents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects / Q000528:radiation effects; D005199:Fanconi Anemia / Q000145:classification / Q000235:genetics*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008730:Methoxsalen / Q000494:pharmacology; D010641:Phenotype; D014466:Ultraviolet Rays
D003432:Cross-Linking Reagents; D004247:DNA; D008730:Methoxsalen