[Evaluation of the bronchial provocation test with histamine in asthmatic children].
Histamine inhalation challenge was performed in 32 asthmatic children aged 6 through 13, 20 control children aged 8 through 14, and 16 control adults aged 24 through 37 years. Histamine concentration producing a 20% fall in baseline FEV1 (PC20FEV1) was obtained. No control adult had a value below 8 mg/ml unlike 7 (35%) control children, all of them with values between 4 and 8 mg/ml. Asthmatics only on intermittent bronchodilators had higher PC20FEV1 values than those requiring daily medications. A value of 2 mg/ml was roughly the limit between these two subpopulations of asthmatic children. Test showed a high reproducibility in a two hour interval. Histamine inhalation challenge is useful in diagnosis of asthma and in assessment of its, severity. A PC20FEV1 value of less than 8 mg/ml may not be always reliable in indicating bronchial hyperreactivity, depending on the method used and-or the population studied.
D000293:Adolescent; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy; D001985:Bronchial Provocation Tests / Q000379:methods*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans
D001993:Bronchodilator Agents; D006632:Histamine
Valoración de la prueba de provocación bronquial con histamina en niños asmáticos.