title: Interaction between Trypanosoma brucei and the ependymal cell of the choroid plexus.
abstract: The fine structure of the normal choroid plexus of rats and mice and of those infected with Trypanosoma brucei was examined by transmission and scanning electron microscopy: extracellular trypomastigotes in the perivascular stroma predominate but the evidence presented suggests that they are derived both from stages in the blood and from others undergoing division within ependymal cells, a process which results in destruction of a large proportion of ependymal cells in the parts of choroid plexus affected. The choroid plexus maintains its integrity by regeneration of an outer layer of ependymal cells.
mesh_terms: D000818:Animals; D002831:Choroid Plexus / Q000469:parasitology* / Q000648:ultrastructure; D004805:Ependyma / Q000648:ultrastructure; D005260:Female; D007365:Intercellular Junctions / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D014346:Trypanosoma brucei brucei / Q000502:physiology*; D014353:Trypanosomiasis, African / Q000473:pathology