Decline of natural killer cell target binding and lytic activity in mice exposed to rotation stress.
We examined the effect of rotation-induced stress on the percentage distribution of NK-YAC-1 target-binding cells and natural killer (NK) cell activity from splenic lymphocytes of C3H/HeJ mice. Following a 6-day stress regimen, we observed a marked decline in both the percentage of target-binding cells and in NK cell activity. This decline was first evident 13 days after initiation of stress and persisted for 2 weeks. Our data indicate that intermittent rotation stress over a 6-day period results in a delayed but persistent deleterious effect on NK-YAC-1 target binding and NK cell activity.
D000818:Animals; D002860:Chromium Radioisotopes; D005260:Female; D007694:Killer Cells, Natural / Q000378:metabolism*; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology; D012399:Rotation; D013312:Stress, Physiological / Q000276:immunology*
D002860:Chromium Radioisotopes