Thiyl and phenoxyl free radicals and NADH. Direct observation of one-electron oxidation.
Absolute rate constants for the reaction of NADH with thiyl free radicals derived from various sulphur-containing compounds of biological significance were measured by using the technique of pulse radiolysis. These and related reactions with phenoxyl free radicals are believed to occur through one-electron-transfer processes. Further evidence comes from studies with deuterated NADH. The results support the possibility that, in biochemical systems, thiols may act as catalysts linking hydrogen-atom and electron-transfer reactions.
D004579:Electron Transport; D005609:Free Radicals; D007700:Kinetics; D009243:NAD; D010084:Oxidation-Reduction; D010636:Phenols; D011675:Pulse Radiolysis; D013438:Sulfhydryl Compounds
D005609:Free Radicals; D010636:Phenols; D013438:Sulfhydryl Compounds; D009243:NAD