Resistance of Cooperia curticei against fenbendazole.
Resistance of Cooperia curticei against fenbendazole was demonstrated in The Netherlands. Experimental infection of lambs followed by intraruminal injection of 5 mg kg-1 showed a 100 per cent survival of the C curticei population. With an in vitro egg development assay LC50 values between 0.23 and 0.38 micrograms ml-1 thiabendazole were found. This is the first record of a Cooperia species resistant against an anthelmintic.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004351:Drug Resistance; D005273:Fenbendazole / Q000627:therapeutic use*; D006373:Helminthiasis / Q000188:drug therapy; D006374:Helminthiasis, Animal; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology*
D001562:Benzimidazoles; D005273:Fenbendazole