Paradoxical effect of dichlorobis(1-phenylbutane-1,3-dionato)molybdenum (IV), (Mo(bzac)2Cl2 on the growth of autochthonous chemically induced colorectal tumors in SD rats.
The influence of dichlorobis(1-phenylbutane-1,3-dionato)molybdenum (IV), (Mo(bzac)2Cl2) in acetoxymethyl-methylnitrosamine (AMMN) induced colorectal cancer in SD rats was assessed. Treatment was given intravenously twice a week for 10 weeks immediately after the end of the induction period (G1 and G2) or following coloscopic diagnosis of the tumors (G4, G5 and G6). Paradoxical therapeutic effect of Mo(bzac)2Cl2 on the growth the AMMN induced colorectal cancer was observed.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D008297:Male; D008982:Molybdenum / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D051381:Rats; D012004:Rectal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; C051981:dichlorobis(1-phenylbutane-1,3-dionato)molybdenum(IV); C014659:methyl(acetoxymethyl)nitrosamine; D008982:Molybdenum; D004128:Dimethylnitrosamine