Accumulation of heat-labile elongation factor 2 in the liver of mice and rats.
Age-related changes of polypeptide chain elongation factor 2 (EF-2) in mouse and rat livers were investigated. The percentage of heat-labile components in EF-2 was 5 to 10% in young animals and 15 to 45% in old ones. These results and other findings (Takahashi et al., in press) support the idea that decrease in translational activity in old animals is due, in part, to alterations of protein components of the translational system.
D000375:Aging; D000818:Animals; D004355:Drug Stability; D006358:Hot Temperature; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D020652:Peptide Elongation Factor 2; D010445:Peptide Elongation Factors