[Decrease in the respiration rate in mice as an indicator of the irritating effects of chemical substances on the upper respiratory tract].
A method of measuring a decrease in the respiration rate as an index of chemical substances irritating effects upon mice's upper respiratory tract has been checked and adopted. A dose of irritating substances resulting in the respiration rate decrease by 50%--RD50 has been determined, as related to exposure to chlorine, ammonia and acrolein. The RD50 values for chlorine and acrolein approximated those quoted by Alarie Y., whereas for ammonia exposure this value differed.
D000171:Acrolein / Q000009:adverse effects*; D000393:Air Pollutants / Q000009:adverse effects*; D000447:Aldehydes / Q000009:adverse effects*; D000641:Ammonia / Q000009:adverse effects*; D000818:Animals; D002713:Chlorine / Q000009:adverse effects*; D007509:Irritants; D008452:Maximum Allowable Concentration; D051379:Mice; D008807:Mice, Inbred BALB C; D012119:Respiration / Q000187:drug effects*
D000393:Air Pollutants; D000447:Aldehydes; D007509:Irritants; D002713:Chlorine; D000641:Ammonia; D000171:Acrolein
Spadek czestości oddychania u myszy jako wskaźnik działania drazniacego substancji chemicznych na górne drogi oddechowe.