[Discovery of hemoglobin J Baltimore in an episode of methemoglobinemia in an infant].
A case of a heterozygote for Hb J Baltimore is reported in a French family. This variant hemoglobin was coincidentally discovered during an episode of methemoglobinemia in a 6-week-old baby. The father and one of the brothers were also carriers of the trait. Hematological findings for all of them were normal. As Hb J Baltimore is a frequently occurring hemoglobin variant, we discuss: its possible role in the appearance of methemoglobin, and whether this mutation in different racial groups (Caucasians of West Europe, Canadians, and American blacks) has a common origin or more probably arises from a number of independent mutations.
D004586:Electrophoresis; D005602:France; D006448:Hemoglobin J / Q000235:genetics / Q000378:metabolism*; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007525:Isoelectric Focusing; D008297:Male; D008708:Methemoglobinemia / Q000097:blood* / Q000235:genetics; D010084:Oxidation-Reduction
D006455:Hemoglobins, Abnormal; D006448:Hemoglobin J; C030639:hemoglobin J Baltimore
Découverte d'une hémoglobine J Baltimore au cours d'un épisode de méthémoglobinémie chez un nourrisson.