[Changes in the anatomic structures and cellular composition of lymph nodes after prenatal exposure to oleandomycin].
Tracheobronchial and mesenteric lymph nodes have been investigated in 120 embryos, fetuses and newborn (5-, 14-, 30-day-old) rats by means of anatomical, histological and electron microscopical methods. Prenatal influence of oleandomycin phosphate on development of lymph nodes has been analysed. Effect of the drug on the mother--fetus system produces certain reactive changes in the anatomical structures responsible for the barrier-filtration and drainage functions of the lymph nodes. The immunocytopoietic function is inhibited, as demonstrates certain decrease of lymphatic line cells.
D000818:Animals; D001980:Bronchi; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000473:pathology; D008643:Mesentery; D009827:Oleandomycin / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea
D009827:Oleandomycin
Izmeneniia anatomicheskikh struktur i kletochnogo sostava limfaticheskikh uzlov posle prenatal'nogo vozdeĭstviia oleandomitsina.