Identification of vitamin K1 chromenol--a novel metabolite of vitamin K1 formed in vitro by a component in blood.
A newly recognized metabolite of vitamin K1, vitamin K1 chromenol, is produced when the vitamin is added to the plasma or serum of a number of species. The metabolite was identified by comparison of its uv and mass spectra and high-performance liquid chromatographic retention times with those of the synthetic vitamin K1 chromenol. In aqueous solution vitamin K chromenol decomposed to a variety of products and reacted with nucleophilic substances. Optimal conditions for its formation and evidence that chromenol formation may be an enzyme catalyzed reaction are presented.
D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D012995:Solubility; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D010837:Vitamin K 1 / Q000031:analogs & derivatives*
D014812:Vitamin K; C051390:vitamin K1 chromenol; D010837:Vitamin K 1