title: Electrolyte levels in the CSF of children with nontumoral hydrocephalus. Relation to clinical parameters.
abstract: The levels of calcium and magnesium (by atomic absorption spectrophotometry), sodium and potassium (by flame photometry), inorganic phosphate and proteins (by spectrophotometry) were measured in the CSF of 27 children with hydrocephalus and compared with the CSF data on 10 controls, so as to study the effect of the blood-brain and blood-CSF barrier alterations observed in hydrocephalus, on the CSF electrolytes. Ca (P less than 0.001), Mg (P less than 0.01) and phosphate (P less than 0.05) were found to be increased, K (P less than 0.01) decreased, and Na levels not significantly altered. Linear regression analysis of hydrocephalic patients showed a linear correlation (r = +0.62) between phosphate and proteins (P less than 0.01) and (r = +0.66) between phosphate and Ca (P less than 0.001). Comparison of control CSF electrolyte levels with those found in the CSF of hydrocephalic patients were grouped according to clinical variables: sex (F, M), age (less than or equal to 1.5 months, greater than 1.5 months), etiological variants (congenital, acquired), treated infection (no, yes), surgical treatment (no, yes), time of onset (less than or equal to 1 month, greater than 1 month), ventricular dilation (mild, severe) and intracranial hypertension (mild or severe). These comparisons showed specific increases of Mg for males (P less than 0.05), acquired hydrocephalus (P less than 0.05) and severe intracranial hypertension (ICH) (P less than 0.001), moderate decrease in the Na levels in acquired hydrocephalus (P less than 0.05) and mild ICH (P less than 0.05), specific increases of phosphate in females (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000293:Adolescent; D001812:Blood-Brain Barrier; D002118:Calcium / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid*; D007223:Infant; D007231:Infant, Newborn; D007427:Intracranial Pressure; D008274:Magnesium / Q000134:cerebrospinal fluid; D008297:Male; D010710:Phosphates / Q000134:cerebrospinal fluid; D011188:Potassium / Q000134:cerebrospinal fluid; D012737:Sex Factors; D012964:Sodium / Q000134:cerebrospinal fluid
chemical_list: D002556:Cerebrospinal Fluid Proteins; D010710:Phosphates; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium