[Dicarboxylic acids inhibit the growth of keratinocytes in vitro].
The antiproliferative effect of three straight-chained saturated dicarboxylic acids was examined with neonatal mouse keratinocyte cultures. Adipic acid (C6), azelaic acid (C9), and sebacic acid (C10) were added to the cultures in concentrations ranging from 1 to 50 mmol/l. Proliferation was assayed by liquid-scintillation counting of 3H-thymidine incorporation into DNA and by autoradiography. Fifty percent inhibition of 3H-thymidine incorporation was observed with 50 mmol/l adipic acid, 20 mmol/l azelaic acid, and 10 mmol/l sebacic acid, respectively. The antiproliferative effect was completely reversible after cessation of treatment. Moreover, treated cultures then showed a rebound effect with increased DNA synthesis. These results show that dicarboxylic acids exert reversible antiproliferative effects on keratinocytes.
D000272:Adipates / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D003652:Decanoic Acids / Q000494:pharmacology; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D051379:Mice; D012867:Skin / Q000166:cytology*
D000272:Adipates; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; C029900:adipic acid; D004247:DNA; C011107:sebacic acid; C010038:azelaic acid
Dicarbonsäuren hemmen das Wachstum von Keratinozyten in vitro.