Preterm premature rupture of the membranes with fetal pulmonary maturity present: a prospective study.
Ninety-nine patients with premature rupture of the membranes (PROM) before 36 weeks' gestation and documented fetal pulmonary maturity were studied prospectively. Fifty-two patients in labor were allowed to deliver. The remaining 47 were randomly assigned to either prompt delivery (N = 26) or conservative management (N = 21). The overall corrected perinatal survival was excellent (96%). Only one death in the entire series clearly was due to prematurity. Expectant management prolonged gestation greater than one week in only four of 21 patients (19%), and was associated with a significantly increased risk of maternal infections. There were no failed inductions of labor, and 22 of 24 induced patients (92%) delivered vaginally. Neonatal morbidity was similar in each group. These findings in an indigent, largely black population suggest that when pulmonary maturity is present, the maternal risks of conservative management may exceed the potential benefit to the fetus and newborn. The findings of this study may be specific to the population studied, and extrapolation to dissimilar populations may not be warranted.
D000328:Adult; D001741:Black or African American; D001724:Birth Weight; D036861:Delivery, Obstetric; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000628:therapy*; D005325:Fetal Organ Maturity; D006801:Humans; D008168:Lung / Q000196:embryology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology; D011379:Prognosis; D011446:Prospective Studies; D011897:Random Allocation; D012306:Risk; D012923:Social Class; D013997:Time Factors