Effect of monofluoromethyldopa (MFMD) on trace amine levels.
The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amines in the kidney, only phenylethylamine and tryptamine levels were decreased in the striatum compared to control. Striatal p-tyramine levels were not affected, while striatal m-tyramine levels were increased by MFMD. When the rats were injected with a monoamine oxidase (MAO) inhibitor before MFMD administration, similar changes in striatal and kidney trace amine levels were observed compared to MFMD alone.
D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D007536:Isomerism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008750:Methyldopa / Q000031:analogs & derivatives* / Q000494:pharmacology; D010627:Phenethylamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014363:Tryptamines / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism*
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D010627:Phenethylamines; D014363:Tryptamines; C029261:phenethylamine; C030820:tryptamine; D008750:Methyldopa; C019494:alpha-monofluoromethyldopa; D014439:Tyramine