Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits.
We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/d). The animals received these diets for 5 months (100 g/d). Aortic atherosclerosis as measured by planimetry of sudanophilic lesions was significantly higher (+59%) in group III as compared with group II, even though serum cholesterol levels were comparable. No differences were found in platelet half-life times between groups II and III, but these values were significantly lower than the half-life of platelets in the control group I. Total serum peroxide levels, expressed as malondialdehyde equivalents were significantly elevated in the fish oil-treated group. This may be due to malondialdehyde modification of the lipoproteins and may be responsible for the enhanced development of atherosclerosis in these animals.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002470:Cell Survival; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000633:toxicity; D004281:Docosahexaenoic Acids; D004338:Drug Combinations; D015118:Eicosapentaenoic Acid; D005231:Fatty Acids, Unsaturated / Q000633:toxicity; D005260:Female; D005395:Fish Oils / Q000633:toxicity*; D006207:Half-Life; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits
D002791:Cholesterol, Dietary; D004042:Dietary Fats, Unsaturated; D004338:Drug Combinations; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; C045153:Maxepa; D004281:Docosahexaenoic Acids; D008315:Malondialdehyde; D015118:Eicosapentaenoic Acid