Severe symptomatic atrioventricular block induced by pilocarpine eye drops.
An 89-year-old man with chronic glaucoma received hourly pilocarpine eye drops for seven hours, when he developed third-degree atrioventricular block with a slow idioventricular escape rate. After discontinuing the pilocarpine, the atrioventricular block gradually disappeared. The site of pilocarpine-related block was most likely within the His-Purkinje system.
D000368:Aged; D004562:Electrocardiography; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006327:Heart Block / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions / Q000009:adverse effects; D010862:Pilocarpine / Q000008:administration & dosage / Q000009:adverse effects*
D009883:Ophthalmic Solutions; D010862:Pilocarpine