title: Combined chemotherapy and surgery for hydatid bone disease.
abstract: Surgical treatment of hydatid bone disease is rarely completely successful because radical excision is only possible at certain sites and secondary infection frequently occurs. Antihelmintic drugs have in the past been only palliative due to poor absorption and consequent low concentration in serum or cysts. We report five patients with Echinococcus granulosus infestation treated with a new chemotherapeutic agent albendazole; in two it was given postoperatively, in two pre-operatively and one child is being followed expectantly. We believe that a combination of chemotherapy and surgery may be efficacious in the treatment of hydatid bone disease.
mesh_terms: D000293:Adolescent; D000368:Aged; D015766:Albendazole; D001562:Benzimidazoles / Q000627:therapeutic use*; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D003131:Combined Modality Therapy; D004443:Echinococcosis / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011292:Premedication; D014057:Tomography, X-Ray Computed
chemical_list: D001562:Benzimidazoles; D015766:Albendazole