[Structural changes in the hepatocytes of old rats with posthemorrhagic anemia].
Using light and electron microscopy, and morphometry, it has been demonstrated that 15 min and 2.5 h after a single blood loss (2% of the body mass) organelle disintegration and destruction are more marked and preserved in hepatocytes of old (25-month-old) rats, as compared to adult (8-month-old) animals. Regenerative processes in adult rats lead to hepatocyte structure normalization already by the 10th hour after the experiment was started, while in old rats disseminated fatty dystrophy of hepatic cells is observed even on day 7. Thus, hepatocytes of old animals are more susceptible to blood-loss-induced disturbances, with the regenerative processes in them being less marked and slower than in adult animals.
D000375:Aging / Q000473:pathology*; D000740:Anemia / Q000209:etiology / Q000473:pathology*; D000818:Animals; D006470:Hemorrhage / Q000150:complications / Q000473:pathology*; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D014176:Protein Biosynthesis; D051381:Rats; D013997:Time Factors
Izmenenie struktury gepatotsitov u starykh krys v usloviiakh postgemorragicheskoĭ anemii.