Anti-ulcerogenic effect of banana powder (Musa sapientum var. paradisiaca) and its effect on mucosal resistance.
Orally administered banana pulp powder (Musa sapientum var. paradisiaca) was shown to have significant anti-ulcerogenic activity in rats subjected to aspirin, indomethacin, phenylbutazone, prednisolone and cysteamine and in guinea-pigs subjected to histamine. Banana powder not only increased mucosal thickness but also significantly increased [3H]thymidine incorporation into mucosal DNA. Relative to untreated control sections, histological studies showed that banana treatment increased staining by alcian blue in the apical cells with staining noted in the deeper layers of the mucosal glands. Banana-treated and control sections were also stained for DNA by the Feulgen reaction. The banana-treated sections showed a greater aggregation and intensity of pink spots when compared to controls. The present study suggests that banana powder treatment not only strengthens mucosal resistance against ulcerogens but also promotes healing by inducing cellular proliferation.
D000818:Animals; D000897:Anti-Ulcer Agents; D004381:Duodenal Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005638:Fruit / Q000032:analysis*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011208:Powders; D051381:Rats; D013045:Species Specificity; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D011208:Powders