The chronopharmacokinetics of indomethacin suppositories in healthy volunteers.
The pharmacokinetics of a single 100 mg indomethacin suppository were studied in 12 healthy volunteers on two occasions at least 7 days apart. Suppositories were administered in randomised order at 9.00 and 21.00 hours to see if there was evidence of a diurnal variation in kinetic parameters. The study failed to show a significant change in single dose kinetics with the time of suppository administration. This is in contrast to previous work [1] demonstrating a circadian rhythm in the kinetics of a single oral dose of indomethacin. This suggests that the chronopharmacokinetics of indomethacin is dependent on the function of the upper gastrointestinal tract.
D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D013488:Suppositories
D013488:Suppositories; D007213:Indomethacin