title: Idiopathic lymphoplasmacytic aortic valvulitis: observations in two elderly women with unexplained aortic insufficiency.
abstract: Two patients with a unique aortic valvulitis required aortic valve replacement. Both were elderly women who presented with evidence of systemic disease, including fever, arthralgia, myalgia, markedly elevated erythrocyte sedimentation rate, anemia, leukocytosis, hypoalbuminemia and renal insufficiency, in addition to progressive subacute aortic insufficiency. Histologic examination of the excised aortic valve revealed a lymphoplasmacytic infiltrate. Neither patient had evidence of other diseases that have been associated with aortic insufficiency. One should consider the judicious use of glucocorticosteroids for such patients.
mesh_terms: D000368:Aged; D001018:Aortic Diseases / Q000150:complications*; D001021:Aortic Valve / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology