Kinetic predominant essential tremor: successful treatment with clonazepam.
Fourteen patients with marked kinetic tremors of long duration but no other major neurologic signs are described. A positive family history of essential tremor, mild postural tremor, and tremor suppression with alcohol suggest that the condition is a variant of essential tremor. Kinetic tremors had a frequency of 3.5 to 6.0 Hz and an alternating EMG pattern. Propranolol caused improvement in some patients, but clonazepam treatment resulted in tremor suppression in all patients. Kinetic tremor without cerebellar signs is a subtype of essential tremor with pharmacologic responsiveness to clonazepam.
D000368:Aged; D000369:Aged, 80 and over; D002998:Clonazepam / Q000627:therapeutic use*; D004576:Electromyography; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D006236:Handwriting; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use; D014202:Tremor / Q000188:drug therapy*
D000431:Ethanol; D002998:Clonazepam; D011433:Propranolol