Polyethylene/hydrophilic polymer blends for biomedical applications.
Polyethylene blends with poly(2-hydroxyethyl methacrylate) [poly(HEMA)] or poly(2,3-dihydroxypropyl methacrylate) [poly(DHPMA)] were prepared by swelling polyethylene with HEMA or 2,3-epoxypropyl methacrylate (EPMA) and by polymerization of the respective monomers. Poly(EPMA) in blends was hydrolysed to poly(DHPMA) with acetic acid. The blends had similar surface and bulk compositions. Swelling with water and surface wettability were proportional to the content of the hydrophilic component; at the same content the polyethylene/poly(DHPMA) blends appeared more hydrophilic than those of polyethylene/poly(HEMA). Thrombus formation in contact with blood examined ex vivo and in vivo was considerably slower on the blends than on unmodified polyethylene. The tests indicated optima in composition; the best biological response was achieved with the blends containing about 14% poly(HEMA) or 16% poly(DHPMA).
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D011095:Polyethylenes / Q000032:analysis* / Q000633:toxicity; D011108:Polymers
D011095:Polyethylenes; D011108:Polymers