[Detection of peranesthetic malignant hyperthermia by muscle contracture tests and NMR spectroscopy].
To diagnose malignant hyperthermia susceptibility (MHS), caffeine and halothane contracture tests were performed on six patients. One of them, who presented a peroperative crisis, was recognized as MHS; the five others were negative (MHN). By means of 31P-NMR spectroscopy, the muscular energetic metabolism of these patients was studied during and after moderate exercise in normal and moderate ischaemic conditions. Metabolic abnormalities appeared in the MHS patient. It must be concluded therefore that malignant hyperthermia is a latent myopathy. 31P-NMR spectroscopy appeared to be a useful non-invasive tool for screening for this affliction.
D001706:Biopsy; D002110:Caffeine; D006221:Halothane; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008305:Malignant Hyperthermia / Q000175:diagnosis* / Q000235:genetics; D009119:Muscle Contraction; D009132:Muscles / Q000473:pathology
D002110:Caffeine; D006221:Halothane
Dépistage de l'hyperthermie maligne anesthésique par les tests de contracture musculaire et par la spectroscopie RMN.