title: Propafenone ingestion.
abstract: Propafenone is a type 1c antiarrhythmic drug that recently has become available for clinical trials within the United States. We present the case of a 2-year-old child who accidentally ingested 1,800 mg (133 mg/kg) of propafenone. The patient subsequently developed cardiac conduction abnormalities and generalized seizures. Following the administration of IV phenytoin, cardiopulmonary collapse occurred. The patient had a successful outcome with aggressive cardiopulmonary life support.
mesh_terms: D002037:Bundle-Branch Block / Q000139:chemically induced / Q000503:physiopathology; D002675:Child, Preschool; D004562:Electrocardiography; D004630:Emergencies; D006323:Heart Arrest / Q000139:chemically induced; D006327:Heart Block / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011405:Propafenone / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced
chemical_list: D011405:Propafenone