The growth and histological characteristics of a series of human bladder cancer xenografts.
Xenografts from human transitional cell carcinoma of the bladder (TCC) have been successfully established in CBA mice which had previously been immune-deprived by thymectomy and whole body irradiation with cytosine arabinoside pre-treatment. Xenografts were established from 3/17 patients with histological grade 2 tumours, 3/19 patients with histological grade 3 tumours, and one from a patient with a mixed transitional cell and squamous cell carcinoma. No xenografts were established from patients with histological grade 1 tumours. All the xenografts maintained the histological characteristics of their parent tumours in early passage, but some developed more prominent squamous features in later generations. Many of the xenografts were cystic.
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D011829:Radiation Dosage; D014183:Transplantation, Heterologous; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000648:ultrastructure