title: Instability of large direct repeats in retrovirus vectors.
abstract: Retrovirus vectors were constructed with large (0.85- to 1.3-kilobase-pair) direct repeats in their genomes. Deletions involving the direct repeats occurred at a high frequency. Deletions occurred both when the direct repeats were in tandem and when they were separated by additional sequences. These deletions occurred during virus replication.
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D004279:DNA, Viral / Q000235:genetics; D005822:Genetic Vectors; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D013155:Spleen Focus-Forming Viruses / Q000235:genetics; D014779:Virus Replication
chemical_list: D004279:DNA, Viral