[Experimental studies on the healing and restoration of gliding function of the injured digital flexor tendon. Part 9: The use of drugs to prevent adhesion formation of the injured tendon].
In order to prevent the formation of restrictive adhesion without influencing tendon healing, hyaluronic acid and triamcinolone were given topically between a scarred tendon and gliding floor. The third digits of female broiler chickens were used. Three factors of tendon adhesion were elicited, namely, injury to the tendon, tendon sheath and gliding floor. Standard adhesion was established from all factors in addition to the cast immobilization. The above-mentioned procedure was used as a standard adhesion model in the following experiments. Hyaluronic acid, triamcinolone and ganglion contents were applied topically just after the above-mentioned procedure. After three weeks of immobilization, the state of tendon adhesion and tendon healing was observed. Triamcinolone, 0.05 mg, had an adhesion-preventing action, but the effective dose of this agent had only narrow limits. Hyaluronic acid, 1% and 0.5%, was more effective than triamcinolone in the prevention of adhesion and did not interfere with the tendon healing. Ganglion contents had a slight effect on the prevention of adhesion.
D000287:Administration, Topical; D000818:Animals; D002645:Chickens; D005260:Female; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008954:Models, Biological; D013708:Tendon Injuries / Q000628:therapy*; D013710:Tendons / Q000502:physiology; D000267:Tissue Adhesions / Q000517:prevention & control; D014221:Triamcinolone / Q000008:administration & dosage / Q000627:therapeutic use*; D014945:Wound Healing
D014221:Triamcinolone; D006820:Hyaluronic Acid