title: Cardiovascular responses to the intracarotid injections of ionic contrast media and iohexol in the dog.
abstract: Hypotension and bradycardia are the most significant cardiovascular responses resulting from intracarotid injections of hypertonic contrast media (CM). We have assessed both local and systemic vascular responses to the selective intracarotid injections of ionic and non-ionic CM in twelve pentobarbital anesthetized dogs. Alterations in blood pressure, heart rate, and femoral, renal and carotid blood flows were monitored following right common carotid artery injections of ionic contrast media (282-288 mg I/ml), isotonic saline, and iohexol (300 mg I/ml). Ionic CM led to early (0 to 10 s) decreases in blood pressure, heart rate and femoral vascular resistance. Isotonic saline induced no significant early changes in these same parameters while iohexol caused a decrease in heart rate. Our observations suggest that the early (0 to 10 s) decreases in femoral vascular resistance, heart rate and pressure that occur with the intracarotid injection of hypertonic CM are mediated via the autonomic nervous system and initiated from a site in the carotid circulation. During the 15 to 40 s period when the CM has reached the systemic circulation, iohexol produced smaller effects on systemic blood pressure and peripheral vascular resistances than did the ionic CM. During this 15 to 40 s period there were decreased vascular resistances in the carotid and renal vascular beds that probably result from local effects of the CM, however, the femoral resistance was actually increased. This later increase in femoral resistance probably represents the results of increased sympathetic nervous system activity working to offset the decrease in renal and carotid resistances and thus maintain pressure at baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries; D003287:Contrast Media / Q000633:toxicity*; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007269:Injections, Intra-Arterial; D007472:Iohexol / Q000633:toxicity*; D008297:Male; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D007472:Iohexol