Weight reduction and salt restriction in hypertension: effects on blood pressure and intracellular electrolytes.
In 16 essential hypertensives on a program of energy restriction (800 kcal/day) with and without simultaneous salt restriction, the effects on blood pressure and intracellular Na+ and Ca2+ in red blood cells were studied. A decrease in blood pressure and intracellular free Na+ and Ca2+ was only observed in the cases of simultaneous energy and salt restriction. The beneficial effect of weight reduction in hypertension thus depends on a diminished salt intake and is probably mediated by changes in intracellular free Ca2+.
D000328:Adult; D001794:Blood Pressure; D001835:Body Weight; D002118:Calcium / Q000097:blood; D004038:Diet, Reducing; D004039:Diet, Sodium-Restricted; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance
D012964:Sodium; D002118:Calcium