title: Diazepam and muscimol blockade of the gastrointestinal motor disturbances induced by acoustic stress in dogs.
abstract: The influence of various drugs on the gastric motor inhibition induced by acoustic stress (AS) was investigated in fasted dogs fitted with strain-gauge transducers implanted on the antrum and proximal jejunum at 10 and 80 cm from the pylorus respectively. Started 40-50 min after the last gastric migrating motor complex (MMC), a 1 h acoustic stress delayed by 75% the occurrence of the next gastric but not jejunal MMC and was associated with a 4-fold increase in plasma cortisol. This AS-induced inhibition of the gastric MMC cycle was abolished after previous administration of diazepam (0.2 and 0.5 mg/kg i.m.) or muscimol (10 micrograms/kg i.v.) and partially reduced by a lower dose of diazepam (0.1 mg/kg i.m.); in contrast, it was still present after either naloxone (0.1 mg/kg i.m.), phentolamine (0.2 mg/kg i.v.) or propranolol (0.1 mg/kg i.v.) treatment. This selective benzodiazepine or GABA agonist blockade of noise-induced gastric motor alteration supports the hypothesis that release of CRF may be responsible for the gastrointestinal motor effects induced by acoustic stress.
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004285:Dogs; D005769:Gastrointestinal Motility / Q000187:drug effects*; D009118:Muscimol / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009622:Noise / Q000009:adverse effects*; D013315:Stress, Psychological / Q000503:physiopathology*; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D013565:Sympatholytics; D009118:Muscimol; D009270:Naloxone; D003975:Diazepam