title: The effect of acute and chronic treatment of verapamil on pressor response to angiotensin II in rats.
abstract: The effect of verapamil on pressor response to Angiotensin II (A II) was investigated in rats. The responses to A II (10, 20, 40 ng, iv) was reduced after verapamil (50 and 100 micrograms, iv per rat) in a dose dependent manner. Treatment for 5 day with verapamil (18 mg/100 g/day, po) let to some reduction in basal blood pressure but pressor response to A II was not changed. Treatment for 20 days significantly reduced the basal blood pressure and increased the responsiveness to A II. it is concluded that Ca++ plays a major role in the pressor responses to A II and that chronic treatment with verapamil may reduce basal blood pressure.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000804:Angiotensin II; D014700:Verapamil