title: Effect of neuraminidase on Fc and C3b receptors on rabbit corneal cells infected with herpes simplex virus.
abstract: The effect of neuraminidase on Fc receptors (FcR) and C3b receptors (C3bR) was studied in epithelial, stromal and endothelial cells of the rabbit cornea infected with type 1 (HSV-1) and type 2 herpes simplex virus (HSV-2) in vitro. FcR were induced on epithelial, stromal and endothelial cells of the rabbit cornea by both HSV-1 and HSV-2, but their activities were not enhanced by neuraminidase. On the other hand, the treatment of HSV-infected corneal cells with neuraminidase resulted in the enhancement of C3bR activities on epithelial, stromal and endothelial cells infected with HSV-1, and the enhancing effect of neuraminidase was more pronounced on corneal endothelial cells. A similar neuraminidase treatment had no significant effect on C3bR activities on the corneal cells infected with HSV-2.
mesh_terms: D000818:Animals; D003179:Complement C3b; D003315:Cornea / Q000378:metabolism* / Q000473:pathology; D066298:In Vitro Techniques; D007635:Keratitis, Dendritic / Q000378:metabolism* / Q000473:pathology; D009439:Neuraminidase / Q000494:pharmacology*; D011817:Rabbits; D011951:Receptors, Complement / Q000187:drug effects*; D011961:Receptors, Fc / Q000187:drug effects*
chemical_list: D011951:Receptors, Complement; D011961:Receptors, Fc; D003179:Complement C3b; D009439:Neuraminidase