[Relation between fibrin/fibrinogen degradation products in malignant fluids and the fibrinolytic activity of the peritoneum].
The mechanism of production of fibrin/fibrinogen degradation products (FDP) in malignant fluid was investigated. Levels of FDP in three malignant fluids were high (1200-3000 mcg/ml), but they declined to about 500 mcg/ml after anti cancer treatment. The average levels of FDP in 12 malignant fluids were almost the same as those in nine benign fluids. In a vitro experiment, the fibrinolytic activity of the peritoneum was found to be much higher than that of the tumor. In conclusion, production of FDP in fluid is more closely related to the fibrinolytic activity of the peritoneum than that of the tumor. Intracavitary administration of antifibrinolytic agents is thought to be effect for malignant effusion.
D001202:Ascitic Fluid / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis; D006801:Humans; D010537:Peritoneum; D013274:Stomach Neoplasms / Q000097:blood*
D005338:Fibrin Fibrinogen Degradation Products