The mechanism of the hypolipidemic effect of garlic oil extract in rats fed on high sucrose and alcohol diets.
The effect of feeding garlic oil to white albino rats maintained on high sucrose and alcohol diets was studied. It is proposed that the mechanism of the hypolipidemic effect of the oil involves the active principle, diallyl disulphide, inactivating enzymes and substrates containing thiol groups in an exchange reaction; increased hydrolysis of triacylglycerols as increased lipase activity is induced by the oil; and the reduction in the biosynthesis of triacylglycerols as NADPH is made unavailable for the process by the metabolism of the oil.
D000498:Allyl Compounds; D000818:Animals; D004032:Diet; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005980:Glutathione Reductase / Q000097:blood / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008049:Lipase / Q000097:blood / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology*; D013440:Sulfides / Q000494:pharmacology*
D000498:Allyl Compounds; D008055:Lipids; D013440:Sulfides; D000431:Ethanol; D013395:Sucrose; C038491:allyl sulfide; D005980:Glutathione Reductase; D008049:Lipase