title: Clastogenic effect of passive smoking on bone marrow polychromatic erythrocytes of NMRI mice.
abstract: The genotoxic effect of passive inhalation of sidestream cigarette smoke on bone marrow polychromatic erythrocytes was studied using male NMRI mice. The animals were placed in individual 145.2-dm3 glass chambers resembling a room provided with normal air flow. They were exposed to the sidestream smoke of a commercial brand of cigarettes smoked by a smoking machine under standard conditions. Increased formation of micronuclei within polychromatic erythrocytes (PCEs) of femoral bone marrow 30 h after passive smoking was regarded as being due to the clastogenic effect of the smoke. Passive inhalation of the diluted sidestream smoke of a single cigarette resulted in a significant increase (P less than 0.01) in the frequency of micronucleated PCEs. This clastogenic activity was found to be dose-dependent.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004920:Erythropoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D009153:Mutagens; D014028:Tobacco Smoke Pollution