title: Colchicine suppression of local inflammation due to calcinosis in dermatomyositis and progressive systemic sclerosis.
abstract: Two girls, one with progressive systemic sclerosis and a second with dermatomyositis, developed calcinosis in the skin of the prepatellar area. Calcinosis was accompanied by local inflammation and skin ulceration. Oral colchicine therapy in a dosage of 1 mg per day was followed within two months by significant regression of local inflammation and healing of the skin ulcers.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002114:Calcinosis / Q000188:drug therapy*; D002648:Child; D003078:Colchicine / Q000627:therapeutic use*; D003882:Dermatomyositis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000188:drug therapy*
chemical_list: D003078:Colchicine