title: Soft tissue sarcoma associated with aluminum oxide ceramic total hip arthroplasty. A case report.
abstract: Malignant tumors around fracture fixation implants have been reported sporadically for many years. Recently, however, reports of sarcomatous degeneration around a standard cemented hip arthroplasty and around cobalt-chromium-bearing hip arthroplasties raise new questions of the malignant potential of metallic ends prostheses. Sarcomatous changes around aluminum oxide ceramics seem not to have been reported in the literature. The present report may be the first documented case of an aggressive soft tissue sarcoma detected 15 months after the patient had an uncemented ceramic total hip arthroplasty. If a causal relationship exists, the incidence of this phenomenon in the United States is 250 times greater than would be expected from statistics on soft tissue sarcoma at the hip. Because of the similarity on plane roentgenograms of this tumor to lesions known to be caused by wear debris, tumors should be included in the differential diagnosis of cases of total hip loosening.
mesh_terms: D000328:Adult; D000535:Aluminum / Q000009:adverse effects*; D000537:Aluminum Oxide / Q000009:adverse effects*; D006615:Hip; D006621:Hip Joint / Q000000981:diagnostic imaging; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011859:Radiography; D012509:Sarcoma / Q000209:etiology* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D000535:Aluminum; D000537:Aluminum Oxide