[Determination of circulating immune complexes and complement activation in patients with urticaria-angioedema syndrome].
In the present study, we examined 102 patients with chronic urticaria and angioedema. The incidence of immune complexes (CIC)-mediated chronic urticaria with complement activation (C3b+) was 11.7% (12/102 patients). The 12 patients with CIC and C3b was divided in three diagnostic groups: with drug adverse reactions; with systemic disorders; without apparent associated pathologies. On the basis of data obtained it is remarkable the necessity of a careful etiologic diagnosis in presence of CIC mediated-chronic urticaria particularly when it is associated with arthralgies and/or elevated erythrocyte sedimentation rate (ESR) because of a likely presence of a serious systemic pathology.
D000799:Angioedema / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003167:Complement Activation; D006801:Humans; D013577:Syndrome; D014581:Urticaria / Q000276:immunology*
D000936:Antigen-Antibody Complex
Rilevazione di immunocomplessi circolanti ed attivazione del complemento in pazienti con sindrome orticaria-angioedema.