Prostaglandin-induced abortion in swine: endocrine changes and influence on subsequent reproductive activity.
Gilts were treated during midgestation with prostaglandin (PG) F to study the efficacy of different treatment regimens on induction of abortion and to determine the adverse consequences of PGF-induced abortion in swine. In study 1, pregnant purebred Duroc gilts (60 to 90 days of gestation) were given (IM) 500 micrograms of cloprostenol (n = 12), 20 mg of dinoprost tromethamine (n = 11), or 10 mg of dinoprost tromethamine repeated 12 hours later by an additional 10 mg of dinoprost tromethamine (n = 11). The percentage of gilts that aborted and percentage of aborted gilts that returned to estrus for each treatment group were as follows: cloprostenol, 91.7% and 100%, respectively; 20 mg of dinoprost tromethamine, 36.4% and 25.0%, respectively; and 10 + 10 mg of dinoprost tromethamine, 100% and 90.9%, respectively. Treatment with cloprostenol and with 10 + 10 mg of dinoprost tromethamine caused more gilts to abort (P less than 0.01) than did treatment with 20 mg of dinoprost tromethamine. Gilts that did not abort were given a second treatment with 10 + 10 mg of dinoprost tromethamine. When the abortions by gilts initially treated with 500 micrograms of cloprostenol or 10 + 10 mg of dinoprost tromethamine were combined with those re-treated with 10 + 10 mg of dinoprost tromethamine, 32 of 33 (97.0%) gilts aborted, and 30 of the 32 (93.8%) aborted gilts returned to estrus.(ABSTRACT TRUNCATED AT 250 WORDS)
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000028:Abortion, Induced / Q000662:veterinary*; D000034:Abortion, Veterinary / Q000139:chemically induced*; D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology; D015237:Dinoprost / Q000031:analogs & derivatives*; D004958:Estradiol / Q000097:blood; D004971:Estrus / Q000187:drug effects; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D015237:Dinoprost; C010714:dinoprost tromethamine