title: Influenza virus replication in human cells exposed to the pesticide emulsifier Atlox.
abstract: The emulsifier Atlox was capable of enhancing the infectivity of influenza virus in Chang human conjunctiva cells. Prior to infection, pre-treatment of cells with 2.5 to 10 ppm of Atlox for 6 to 8 h was necessary to detect an increase in virus production. Although there was no difference in the amount of adsorbed virus, the number of successfully infected cells was at least 1 log higher in Atlox treated cells as compared to the controls. Monitoring the 51Cr release from Atlox treated cells indicated a temporary change in membrane structure of the cells as one of the mechanisms of virus enhancement.
mesh_terms: D002460:Cell Line; D002860:Chromium Radioisotopes; D003228:Conjunctiva; D004261:DNA Replication / Q000187:drug effects*; D005079:Excipients / Q000494:pharmacology*; D005278:Fenitrothion / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000235:genetics*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D002860:Chromium Radioisotopes; D005079:Excipients; D011092:Polyethylene Glycols; C048520:atlox; D005278:Fenitrothion