Characterization of collagens in phenytoin-enlarged human gingiva.
The collagen content and composition of human gingivae enlarged due to phenytoin medication were compared to normal and inflamed gingival tissues. Phenytoin-enlarged gingiva contained significantly higher amounts of collagen. The ratio of type I to type III collagen was different in enlarged tissue, with less type I and an elevated amount of type III collagen present. The amount of type V collagen did not differ among normal, inflamed and phenytoin-enlarged gingivae.
D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000032:analysis* / Q000145:classification; D005260:Female; D005881:Gingiva / Q000378:metabolism; D005885:Gingival Hyperplasia / Q000139:chemically induced / Q000378:metabolism*; D005891:Gingivitis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*
D010672:Phenytoin; D003094:Collagen