[Effect of solcoseryl on oxygen metabolism and growth of experimental tumors].
Antihypoxant and antitumour properties of solcoseryl were studied on intact and tumour-bearing rats and mice. By the polarographic method it is found that solcoseryl increases the oxygen metabolism only in animal hypoxic tissues and improves, probably, energy production of their mitochondria. On many tumour strains it is shown that the injections of solcoseryl decelerate the growth of some tumours, inhibit the metastatic process and produce no toxic effect on the animals.
D000183:Actihaemyl / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D051379:Mice; D008815:Mice, Inbred Strains; D008930:Mitochondria, Liver / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D000183:Actihaemyl
Vliianie solkoserila na kislorodnyĭ obmen i techenie opukholevogo protsessa v éksperimente.