title: [Studies on the antigenicity of MY-5116].
abstract: Antigenicity of MY-5116 was studied in the experimental animals and the following results were obtained. MY-5116 was shown to be non-immunogenic in rabbits, guinea pigs and mice when given alone as immunogen. Protein conjugate of MY-5116 induced antibody of hapten specific antibody when using guinea pigs and mice as immunizing species. However, MY-5116 was shown to be not capable of reaction with anti MY-5116-OVA antibodies. Guinea pigs had no skin contact sensitivity against MY-5116 examined by means of maximization test. In conclusion, MY-5116 lacks immunogenicity and eliciting antigenicity in this experimental conditions and this suggests that drug allergic response would either not occur or be minimal, if any, when MY-5116 is administered clinically.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005260:Female; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D011804:Quinolines / Q000276:immunology*; D015363:Quinolones; D011817:Rabbits; D051381:Rats; D012882:Skin Tests
chemical_list: D007074:Immunoglobulin G; D011804:Quinolines; D015363:Quinolones; D007073:Immunoglobulin E; C048522:repirinast