Inhibition of voluntary ethanol intake in rats by a combination of dihydroergotoxine and thioridazine.
Dihydroergotoxine (DHET) decreased voluntary ethanol intake in rats selected for their stable ethanol preference (mean daily ethanol intake 8 g/kg). DHET inhibition was markedly potentiated by thioridazine. The potentiation is explained with a synergistic inhibitory effect on dopaminergic transmission: that is, DHET acting on dopamine (DA) autoreceptors and thioridazine preferentially inhibiting postsynaptic DA receptors.
D000428:Alcohol Drinking / Q000187:drug effects*; D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004357:Drug Synergism; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013881:Thioridazine / Q000494:pharmacology*
D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D004088:Dihydroergotoxine; D013881:Thioridazine