[Usefulness of the determination of drugs in serum. Double-blind study with phenobarbital].
A double-blind study to analyze usefulness of serum phenobarbital measurements has been done. First 125 measurements requested by five pediatrician to 70 child after introduction of this analysis in our laboratory have been analyzed. Results obtained indicate that 24% of determinations were under therapeutic range (TR) and that 22 children (31.4% of total) had in some moment of their treatment values under TR. With regard to each pediatrician, percentage of requested determinations under TR varied from zero to 55%. In conclusion we indicate usefulness to serum phenobarbital measurement to individualized doses and to detect noncompliance or abnormalities in drug absorption, distribution, biotransformation and excretion.
D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010634:Phenobarbital / Q000097:blood* / Q000627:therapeutic use
D010634:Phenobarbital
Utilidad de la determinación de fármacos en suero. Estudio a doble ciego con fenobarbital.