Effects of N-acetyl-DL-methionine on the liver, GSH synthesis and plasma ALAT level in male Bom:NMRI mice.
A single high peroral dose of N-acetyl-DL-methionine (859.5 mg/kg) was administered to Bom:NMRI male mice using methylcellulose as a drug vehicle. The administration of a single high peroral dose of N-acetyl-DL-methionine (859.5 mg/kg) to Bom:NMRI male mice caused an inhibition of the hepatic glutathione decrease compared to a control group treated with methylcellulose only. N-acetyl-DL-methionine caused a reduction and time delay of the hepatic glutathione decrease found in the group treated with methylcellulose only. There was no observed cellular damage of the liver or kidneys assessed histologically or by plasma ALAT after dosing with a racemic mixture of N-acetyl-DL-methionine.
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D005978:Glutathione / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice
C006379:N-acetylmethionine; D008715:Methionine; D000410:Alanine Transaminase; D005978:Glutathione