title: [Plasma level of testosterone-estradiol-binding globulin in women with Itsenko-Cushing disease].
abstract: A total of 50 patients with Icenko-Cushing's disease were examined for the levels of estradiol, testosterone and testosterone-binding globulin in various stages of the disease. In disease recurrences the levels of testosterone were two-fold higher than those in normal subjects versus the testosterone-estradiol-binding capacity (TEBC) in the blood serum which was decreased in patients with Icenko-Cushing's disease. During remission the levels of testosterone decreased, those of the blood TEBC increased, but however failed to achieve their values in health. Normalization of the above mentioned levels followed a total adrenalectomy. The levels of TEBC and testosterone were in a feedback correlation whereas no correlation was recorded between the levels of estradiol and TEBC. The TEBC levels estimation can be used for the assessment of the disease clinical course.
mesh_terms: D000293:Adolescent; D000315:Adrenalectomy; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000601:surgery; D005260:Female; D006801:Humans; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
chemical_list: D012738:Sex Hormone-Binding Globulin
vernacular_title: Soderzhanie testosteron-éstradiolsviazyvaiushchego globulina v plazme krovi zhenshchin, stradaiushchikh bolezn'iu Itsenko-Kushinga.