[Role of erythrocytes in thromboembolism pathology].
The association of erythrocyte disorders and thrombosis in polycythemia vera, paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell anemia suggest that erythrocyte abnormality, could be involved in the genesis of thrombosis. A significant correlation between the hematocrit level and the incidence of thrombosis has been reported indicating the role of blood viscosity, but did to exclude an intrinsic red cell. Thrombotic episodes in sickle cell anemia might be explained by a decreased deformability and an increased adhesion of red cells to endothelium. The incidence of thrombosis is of 40 p. 100 in patient with PNH with a frequent sus-hepatic localization. In addition to abnormal erythrocyte adhesion, abnormal membrane lipid distribution was observed in PNH, suggesting that they could participate in the pathophysiology of thrombosis.
D000755:Anemia, Sickle Cell / Q000097:blood; D004912:Erythrocytes / Q000502:physiology*; D004913:Erythrocytes, Abnormal / Q000502:physiology; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood; D006801:Humans; D011087:Polycythemia Vera / Q000097:blood; D013923:Thromboembolism / Q000097:blood*
Rôle des globules rouges dans la pathologie thromboembolique.