title: Serum and bone concentrations of cefuroxime in patients undergoing knee arthroplasty.
abstract: Concentrations of cefuroxime were measured in the serum and femoral and tibial bone of 12 patients undergoing knee arthroplasty, following cefuroxime 1.5 g iv. The mean serum cefuroxime concentration was 112.4 mg/l at the time of application of the mid thigh tourniquet. The mean femoral bone concentration was 18.6 mg/kg and tibial bone was 15.5 mg/kg. These concentrations of cefuroxime appear adequate for prophylaxis against post-operative infection in knee arthroplasty.
mesh_terms: D001178:Arthroplasty; D002444:Cefuroxime / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D002511:Cephalosporins / Q000032:analysis*; D005260:Female; D005269:Femur / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D007719:Knee Joint / Q000601:surgery*; D008297:Male; D011292:Premedication; D013977:Tibia / Q000032:analysis*
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime