title: [Indications for ligation of ductus arteriosus Botalli persistens in premature infants].
abstract: Ligation of patent ductus arteriosus can be safely performed even in the smallest prematures and may be life-saving. Medical treatment with prostaglandin-inhibitors may be substituted in selected cases. From 1976-1985 a total of 215 prematures was treated. 52 of those experienced spontaneous closure. In 68 infants closure occurred following indomethacin-treatment. 48 had operation after failure of medical therapy and 53 with contraindications to indomethacin were primarily operated. The overall mortality reached 20% and was highest among those with combined medical and surgical treatment.
mesh_terms: D001724:Birth Weight; D004374:Ductus Arteriosus, Patent / Q000601:surgery*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000601:surgery*; D008026:Ligation; D012306:Risk
vernacular_title: Indikation zur Ligatur des Ductus arteriosus Botalli persistens beim Frühgeborenen.