Lack of effect of compound 48/80 on human umbilical vein endothelium.
Human umbilical veins have been treated with compound 48/80, a histamine liberator factor, in order to obtain information about the histamine content in the Weibel-Palade bodies. Ultrastructural observations show a lack of effect in the morphology of this organelle. Our findings suggest that the Weibel-Palade bodies are not histamine storage organelles in human umbilical vein.
D004727:Endothelium / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D011247:Pregnancy; D014471:Umbilical Veins / Q000187:drug effects / Q000648:ultrastructure; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003189:p-Methoxy-N-methylphenethylamine