Cholinesterases in cerebrospinal fluid. A longitudinal study in Alzheimer disease.
We measured acetylcholinesterase (AChE) and butyrylcholinesterase activities in the lumbar cerebrospinal fluid (CSF) of 39 patients with dementia of Alzheimer type and 21 age-matched controls. The mean lumbar CSF AChE activity in our patients did not differ significantly from that of controls. The 7S and 11S molecular forms were also unchanged. When CSF was analyzed at six-month intervals, there was no significant decline in AChE activity over a span of 12 months. Our results and those of previous studies demonstrate that CSF AChE is not a useful diagnostic marker of Alzheimer disease.
D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D046911:Macromolecular Substances; D008297:Male; D008875:Middle Aged
D002556:Cerebrospinal Fluid Proteins; D046911:Macromolecular Substances; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase