Effects of lipophilic derivatives of L-ascorbic acid and dehydro-L-ascorbic acid on the peroxidation of linoleic acid in neutral phosphate buffer containing alcohol.
6-O-Palmitoyl-AsA (AP) and -DHA (DHAP) suppressed LA peroxidation considerably in both 10% and 20% EtOH solutions. The duration of the suppression of LA peroxidation was longer with AP than with DHAP. But after the initial suppression of LA peroxidation, both derivatives showed an accelerating effect. 6-O-Acetyl-AsA (Ac-AsA) and -DHA (Ac-DHA) accelerated LA peroxidation from the start of the reaction in 10% EtOH, but suppressed it notably in 20% EtOH. 4-Phenyl-2,3-dihydroxy-2-buten-4-olide (PDHB) and 4-phenyl-2,3-dioxo-4-butenolide (PDOB) accelerated LA peroxidation in 10% EtOH. With 20% EtOH solution, PDHB suppressed LA peroxidation notably, as did AP, but PDOB showed only a short duration (about 1 h) of suppression. These results suggest the complexity of LA peroxidation catalyzed by lipophilic AsA or DHA in aqueous solution containing alcohol.
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D002021:Buffers; D003683:Dehydroascorbic Acid / Q000494:pharmacology*; D000431:Ethanol; D019787:Linoleic Acid; D008041:Linoleic Acids; D008054:Lipid Peroxides; D010084:Oxidation-Reduction; D010710:Phosphates
D002021:Buffers; D008041:Linoleic Acids; D008054:Lipid Peroxides; D010710:Phosphates; C050982:4-phenyl-2,3-dioxo-2-buten-4-olide; C050980:6-O-acetylascorbic acid; C050981:4-phenyl-2,3-dihydroxy-2-buten-4-olide; D000431:Ethanol; D019787:Linoleic Acid; D015107:4-Butyrolactone; D001205:Ascorbic Acid; C031226:6-O-palmitoylascorbic acid; D003683:Dehydroascorbic Acid