Analgesic effects of N-acetylmuramyl-L-alanyl-D-isoglutamine in decreasing the acetic acid-induced abdominal-writhing response.
A new pharmacological action of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) is described. Pretreatment of male ddY mice with MDP, but not its biologically inactive analogs, significantly decreased the frequency of acetic acid-induced writhing movements more effectively than did acetylsalicylic acid (aspirin). The analgesic effect of MDP, however, was less than that of a narcotic antagonist, pentazocine.
D000085:Acetates; D019342:Acetic Acid; D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013329:Structure-Activity Relationship
D000085:Acetates; D000700:Analgesics; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D019342:Acetic Acid