Benzamides and cholinesterases.
At certain doses metoclopramide (MT), sulpiride and bromopride produce anti-cholinesterase effects as shown by studies on the serum and erythrocyte cholinesterases of the rabbit and the dog, and by those on the hypotensive effect of ACh incubated with rabbit serum in the presence or absence of MT. The anti-cholinesterase effect of MT was more intensive than that of sulpiride, bromopride, procainamide or procaine, but less pronounced than that of prostigmine.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000097:blood; D004285:Dogs; D004912:Erythrocytes / Q000201:enzymology; D066298:In Vitro Techniques; D008787:Metoclopramide / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits; D013469:Sulpiride / Q000494:pharmacology
D001549:Benzamides; D002800:Cholinesterase Inhibitors; C013855:bromopride; D013469:Sulpiride; D002802:Cholinesterases; D008787:Metoclopramide; D000109:Acetylcholine