title: Severe febrile reaction to isoniazid.
abstract: A case of severe febrile reaction to INH is described. The patient had a mild febrile reaction two weeks following INH prophylaxis. Isoniazid was discontinued. Two weeks later and on rechallenge with INH she developed a severe febrile reaction with protracted hypotension. An initial mild febrile reaction to INH is a warning sign that rechallenge can result in a life-threatening situation.
mesh_terms: D000208:Acute Disease; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007538:Isoniazid / Q000009:adverse effects*; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007538:Isoniazid