Cytogenetic studies on B-cell leukemias of AKR origin.
The karyotype of B-cell leukemias of AKR origin was studied by G-banding. In contrast to previous observations indicating trisomy of chromosome 15 in spontaneous and chemically-induced B-cell leukemias, 11 out of 15 tumors analyzed had normal diploid karyotypes. Four tumors with the modal number 39-41 had different chromosome markers specific for each tumor. The possible correlation between non-random chromosomal changes and the target cell involved in the initial transformation in AKR leukemogenesis is discussed.
D000818:Animals; D002460:Cell Line; D002875:Chromosomes / Q000648:ultrastructure; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR