[Effect of feed antibiotics on ampicillin pharmacokinetics in chickens].
Experimental studies with broiler birds revealed that medicated feed (flavophospholipol, vitamyacin A, and the A-149 antibiotic in stimulative doses), offered in the course of two weeks, led to changes in the pharmacokinetic parameters of ampicillin administered i/v (in the form of ampicillin-Na) and via the crop (in the form of ampicillin-trihydrate at 30 mg/kg). It was found that the biologic half-life of ampicillin-Na was prolonged by A-149, and was shortened by vitamicin A, and to a certain extent--by flavophospholipol; the seeming volume of distribution was shown to rise by A-149, and to a certain extent--by flavophospholipol, and was lowered by vitamycin A. The biologic half-life of ampicillin-trihydrate was prolonged by all three ergotropic agents. The systematic bioavailability of ampicillin-trihydrate rose with the use of A-149, and dropped with the use of vitamycin A, and to a lower extent--with the use of flavophospholipol. On the base of the changes established in the pharmacokinetic parameters ampicillin-trihydrate was dosed for use via the drinking water as follows: 196 mg/l simultaneously with flavophospholipol in the feed, 156 mg/l--with the use of vitamycin A, 148 mg/l--when used with the A-149 antibiotic, and 216 mg/l--when administered at no medication via the feed.
D000667:Ampicillin / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002645:Chickens / Q000378:metabolism*; D004347:Drug Interactions; D006207:Half-Life; D007700:Kinetics; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000667:Ampicillin
Vliianie na niakoi nutritivni antibiotitsi vŭrkhu farmakokinetikata na ampitsilina pri pileta.