[The effect of the hydrogen ion concentration on membrane transport of dissociated drugs from saturated solutions].
Dissociating drugs diffuse from saturated solutions with suspended drug particles across lipophilic membranes according to zero order kinetics. The highest rate is maintained even if large fractions of the drug are dissociated due to the pH-conditions of the solution. The pH range of the highest and pH-independent membrane transport corresponds with drug solubility/pH-profiles, showing the solubility of the undissociated drug.
D002271:Carbutamide / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D004115:Dimethindene / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012995:Solubility; D012996:Solutions
D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D012996:Solutions; D004115:Dimethindene; D002271:Carbutamide
Einfluss der Wasserstoffionenkonzentration auf den Membrantransport dissoziierender Arzneistoffe aus gesättigten Lösungen.