Epithelioid hemangioendothelioma of the liver. Report of two cases histologically mimicking veno-occlusive disease.
This report describes two patients with epithelioid hemangioendothelioma presenting with multiple tumour nodules in the liver, but without evidence of tumour elsewhere. One patient died in liver failure twelve months after presentation. The other patient has been well for over two years. Histologically the tumours were remarkably similar, being composed of a proliferation of primitive endothelial cells embedded in a myxohyaline stroma, infiltrating central veins, hepatic sinusoids and, to a lesser extent, terminal portal venules. In each case an initial mistaken histological diagnosis of veno-occlusive disease was made.
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006390:Hemangioendothelioma / Q000473:pathology*; D006504:Hepatic Veno-Occlusive Disease / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male