[Experimental evaluation of tumor therapy with cytostatic agents deposited in the abdominal cavity in acetylcellulose].
For the purpose of improving the effectiveness of the chemotherapy of gastrointestinal tract tumours, the experimental investigation of the possibility to deposit the various antitumour preparations in the abdominal cavity by including them into acetylcellulose microspheres was carried out. It was shown that the use of the polymeric drug complexes permits obtaining a significantly more pronounced antitumour effect than the introduction of the same preparation in a free form. A decrease of the toxic effect of the deposited preparations was established.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002482:Cellulose / Q000031:analogs & derivatives*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008863:Microspheres; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; C005062:acetylcellulose; D003520:Cyclophosphamide; D002482:Cellulose; D005472:Fluorouracil
Eksperimental'naia otsenka terapii opukholeĭ tsitostaticheskimi preparatami, deponirovannymi v briushnoĭ polosti atsetiltselliulozoĭ.