Chemical and biological evaluation of heparinized poly(amido-amine) grafted polyurethane.
By a simple process poly(amido-amine) chains have been grafted onto the surface of polyurethane. The poly(amido-amine) was found to be able to complex heparin by electrostatic interaction. Heparin can be released only at pH greater than 10 with NaOH solution. The heparin adsorbing capacity of the material was biologically tested, and the anticoagulant activity of the heparinized polyurethane was demonstrated.
D000327:Adsorption; D001777:Blood Coagulation / Q000187:drug effects*; D002113:Calcification, Physiologic; D006493:Heparin / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes / Q000032:analysis* / Q000633:toxicity; D013499:Surface Properties
D011140:Polyurethanes; D006493:Heparin