title: Physicochemical properties of the mouse plasmacytoma cell membranes with modified phospholipids.
abstract: Earlier work from our laboratory has demonstrated that the modification of membrane phospholipid composition markedly retards secretion of immunoglobulin G1 by mouse plasmacytoma MOPC-31C cells. In the present study, we examined the physicochemical properties of lipid vesicles prepared from these cells with modified phospholipids by analyzing temperature dependence of 1H NMR signal line-widths of fatty-acyl chains. The results suggest that the export of IgG1 is affected by the local microenvironment of membranes rather than the bulk fluidity.
mesh_terms: D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000648:ultrastructure*; D005227:Fatty Acids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000032:analysis*; D051379:Mice; D010743:Phospholipids / Q000032:analysis*; D010954:Plasmacytoma / Q000648:ultrastructure*
chemical_list: D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids