Intravenous bumetanide attenuates the rise in plasma vasopressin concentrations during major surgical operations.
During a study in seven patients on the endocrine response to major surgical procedures under general anaesthesia an incidental finding was that the administration of intravenous bumetanide prior to surgical stimulation led to reduced concentrations of plasma vasopressin (AVP) when compared with a control group of patients.
D001127:Arginine Vasopressin / Q000097:blood; D002034:Bumetanide / Q000494:pharmacology*; D003864:Depression, Chemical; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D014554:Urination / Q000187:drug effects; D014667:Vasopressins / Q000097:blood*
D004232:Diuretics; D002034:Bumetanide; D014667:Vasopressins; D001127:Arginine Vasopressin