Sex differences in the production of methaemoglobinaemia by 4-aminopropiophenone.
A methaemoglobin former, 4-aminopropiophenone (p-aminopropiophenone, PAPP), which is active only after metabolic activation in vivo, exhibits a sex difference in male Beagle dogs and bitches. Bitches produced more methaemoglobin for a given dose of PAPP than male dogs. The probable reason for this difference was a lower rate of N-hydroxylation in male dogs.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D011427:Propiophenones
D011427:Propiophenones; C029564:4-aminopropiophenone