title: Actin genes in Xenopus and their developmental control.
abstract: The results summarized here have established the temporal and regional activation of three kinds of Xenopus actin genes. The cardiac and skeletal muscle actin genes are among the first cell-type-specific genes to be expressed in early development. The first transcripts to be synthesized by these genes appear to be correctly initiated, spliced, and at once translated into proteins. Both cardiac and skeletal actin genes are strongly transcribed in the axial skeletal muscle of embryos. The mechanism by which the cardiac actin gene is first transcribed in only the somite region of an embryo depends, at least in part, on materials already localized in the subequatorial region of a fertilized but uncleaved egg. Cells which acquire this material seem able to activate their cardiac actin genes without requiring normal contact with other cells.
mesh_terms: D000199:Actins / Q000235:genetics*; D000818:Animals; D001755:Blastocyst; D005796:Genes; D013997:Time Factors; D014158:Transcription, Genetic; D014981:Xenopus / Q000196:embryology* / Q000235:genetics
chemical_list: D000199:Actins