Macrophages in the peripheral nervous system and astroglia in the central nervous system of rat commonly express apolipoprotein E during development but differ in their response to injury.
Macrophages have been identified by immunocytochemical methods in rat sciatic nerve neonatal development expressing significant amounts of apolipoprotein E (apo E). In contrast, in mature peripheral nerve apo E appears to be associated with the basal lamina. Following sciatic nerve crush apo E-immunoreactive macrophages reappear in the denervated distal stump within 3 days. In the optic nerve and spinal cord of newborn rat apo E is associated with the astroglia. During maturation of the central nervous system the number of apo E-immunoreactive astrocytes significantly increases, but as a specific response to injury this protein rapidly disappears from the astroglial cell bodies.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D001253:Astrocytes / Q000378:metabolism*; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D009409:Nerve Crush; D009900:Optic Nerve / Q000254:growth & development / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000254:growth & development / Q000293:injuries / Q000378:metabolism*; D013116:Spinal Cord / Q000254:growth & development / Q000378:metabolism
D001057:Apolipoproteins E