Megakaryoblastic transformation of Ph positive chronic granulocytic leukemia.
A case of well-documented and illustrated megakaryoblastic transformation in a patient with chronic granulocytic leukemia is presented. The salient features of this case were the presence of megakaryoblasts in the peripheral blood and bone marrow and characteristic cytochemical and electron microscopic findings. In addition, the authors observed an unusual, previously unreported, similarity of the abnormal platelets with those described in the Gray platelet syndrome. A literature review of the 13 previously described cases is included.
D000328:Adult; D001853:Bone Marrow / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008533:Megakaryocytes / Q000473:pathology* / Q000648:ultrastructure