Neuropeptide Y-like immunoreactivity in neuritic plaques of Alzheimer's disease.
Alzheimer's disease, a form of senile dementia, is characterized by the presence of neuritic plaques and neurofibrillary tangles throughout the cortex and hippocampus. This study demonstrates the presence of neuropeptide Y-like immunoreactivity within 10-20% of neuritic plaques. Neuropeptide Y is a 36 amino acid peptide which is distributed unevenly throughout the brain and has an interneuronal location.
D000544:Alzheimer Disease / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D005456:Fluorescent Dyes; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009474:Neurons / Q000032:analysis*; D009478:Neuropeptide Y; D014018:Tissue Distribution
D005456:Fluorescent Dyes; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y