Synthesis of some analogs of estradiol.
As part of a search for estradiol derivatives designed for conjugation to carboxyl or amine functions of anti-cancer agents or suitable derivatives thereof, estradiol analogs with side chains at the C-16 or -17 position were prepared for biological assay. These analogs include several which have a substituted nitrogenous function at C-17. The avidity of some of these analogs for binding to estrogen receptor was found to be of a low order.
D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D011960:Receptors, Estrogen / Q000378:metabolism; D014747:Vinblastine / Q000031:analogs & derivatives*
D011960:Receptors, Estrogen; D004958:Estradiol; D014747:Vinblastine