On the role of the spleen in Friend virus (F-MuLV-P) erythroleukemia.
About 30% of Friend virus (F-MuLV-P)-infected C57BL/6 mice became leukemic more than ten weeks after virus infection. This late leukemia development could not be essentially influenced by drug treatment, such as injection of hydroxyurea (2 X 500 mg/kg), actinomycin D (3 X 120 micrograms/kg), phenylhydrazine (3 X 60 mg/kg), or 30 micrograms endotoxin or by bone marrow transplantation following lethal irradiation. Endotoxin (30 micrograms) given prior to virus caused the loss of resistance to F-MuLV-P, but it had only a slight effect if applied one or three months after virus infection. Leukemia development has never been observed in C57BL/6 mice after splenectomy. In DBA/2 mice, highly susceptible to F-MuLV-P, leukemia development was markedly impaired if the mice were splenectomized. These results clearly indicate that the spleen plays a crucial role in the mechanism of susceptibility or resistance to the Friend virus.
D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D005622:Friend murine leukemia virus; D006400:Hematocrit; D006918:Hydroxyurea / Q000494:pharmacology; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology / Q000503:physiopathology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010659:Phenylhydrazines / Q000494:pharmacology; D012156:Reticulocytes / Q000473:pathology; D012475:Salmonella; D013154:Spleen / Q000503:physiopathology; D013156:Splenectomy
D004731:Endotoxins; D008070:Lipopolysaccharides; D010659:Phenylhydrazines; C030299:phenylhydrazine; D003609:Dactinomycin; D006918:Hydroxyurea