Organ distribution of aluminium in uremic rats: influence of parathyroid hormone and 1,25-dihydroxyvitamin D3.
Investigations were performed in order to see whether or not the application of parathyroid hormone or 1,25-dihydroxyvitamin D3, or both might influence the organ distribution of orally and parentally administered aluminium in control and uremic rats. The data show that 1,25-dihydroxyvitamin D3, affects the organ uptake in a different way than parathyroid hormone. Whereas parathyroid hormone increased the aluminium concentration in the liver, 1,25-dihydroxyvitamin D3 enhanced the aluminium uptake in the heart and the muscle, on the other hand, simultaneous application of 1,25-dihydroxyvitamin D3 and parathyroid hormone decreased the aluminium content of the bone, liver and brain.
D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D008297:Male; D009392:Nephrectomy; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution / Q000187:drug effects; D014508:Urea / Q000097:blood; D014511:Uremia / Q000378:metabolism*
D010281:Parathyroid Hormone; D014508:Urea; D003404:Creatinine; D000535:Aluminum; D002117:Calcitriol