Tourette syndrome, pimozide, and school phobia: the neuroleptic separation anxiety syndrome.
The development of school phobia has been reported in some patients with Tourette syndrome treated with haloperidol. The author reports on a patient who developed school phobia on each of three trials with pimozide, a neuroleptic chemically similar to haloperidol, and proposes the term "neuroleptic separation anxiety syndrome." The syndrome is clinically indistinguishable from DSM-III criteria for school phobia (separation anxiety disorder). Tricyclic antidepressants may have a therapeutic or prophylactic effect. It is not known whether this neuroleptic side effect occurs in patients other than those with Tourette syndrome.
D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001010:Anxiety, Separation / Q000139:chemically induced* / Q000188:drug therapy; D002648:Child; D006220:Haloperidol / Q000009:adverse effects; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000139:chemically induced* / Q000188:drug therapy; D010868:Pimozide / Q000009:adverse effects*; D013577:Syndrome; D009626:Terminology as Topic; D005879:Tourette Syndrome / Q000188:drug therapy*
D000929:Antidepressive Agents, Tricyclic; D010868:Pimozide; D006220:Haloperidol