Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord.
Two novel peptides eliciting a potent stimulant effect on the rat uterus smooth muscle have been purified and identified in porcine spinal cord. These peptides were designated as neuromedin U-8 (8 amino acids long) and U-25 (25 amino acids long) referring to their uterus stimulating activity. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-terminus, preceded by paired Arg residues, implicating their biosynthetic relationship. Their potent uterus stimulating activity and hypertensive effect, as well as their unique C-terminal amide structure are indicative of their specialized physiological function.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006973:Hypertension / Q000139:chemically induced; D009419:Nerve Tissue Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D009479:Neuropeptides; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*; D013329:Structure-Activity Relationship; D013552:Swine; D014590:Uterine Contraction / Q000187:drug effects*
D000596:Amino Acids; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C046270:neuromedin U 8; C046271:neuromedin U 25