Rohdei-litorin: a new peptide from the skin of Phyllomedusa rohdei.
The bombesin-litorin family of peptides is characterized by the common amino acid sequence-Gly-His-X-Met-NH2 at the C-terminus, where X is a hydrophobic or aromatic residue. A new member of this family, rohdei-litorin, has been isolated from amphibian skin and its structure shown to be: Glp-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2. This new peptide displayed a greater affinity than other members of the family for rat urinary bladder receptors. A litorin-like peptide, with high affinity for this kind of receptor, has already been described in mammalian spinal cord and named neuromedin B. Rohdei-litorin shares with neuromedin B the entire C-terminal octrapeptide and may be considered the amphibian counterpart of this mammalian neuropeptide.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001001:Anura; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D002918:Chymotrypsin / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000187:drug effects; D007420:Intestine, Large / Q000187:drug effects; D008322:Mammals; D009842:Oligopeptides / Q000032:analysis* / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D012867:Skin / Q000032:analysis*; D001743:Urinary Bladder / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D000596:Amino Acids; D009842:Oligopeptides; C010212:litorin; C044847:Rohdei-litorin; D002918:Chymotrypsin; D011761:Pyrrolidonecarboxylic Acid