[Light microscopic studies of spermatogenesis in rats following the administration of a high dose of 13-cis-retinoic acid].
In an experimental study, we investigated the influence of a toxic dose of 13-cis-retinoic acid (40 mg per kg body weight daily) on the spermatogenesis of 30 Wistar rats. 15 rats were killed immediately after 8 weeks application; the remaining 15 animals were put to death after another 8 weeks without application. A control group of another 20 rats only received physiological salt solution daily over a period of 8 weeks. All 30 rats which had been treated with 13-cis-retinoic acid showed as normal a spermatogenesis in all parts of the testes as the 20 control animals.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D015474:Isotretinoin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis / Q000187:drug effects*; D013723:Teratogens / Q000008:administration & dosage / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*
D013723:Teratogens; D014212:Tretinoin; D015474:Isotretinoin
Lichtmikroskopische Untersuchungen an der Spermatogenese bei Ratten nach hochdosierter Applikation von 13-cis-Retinsäure.