Dominant lethal study in male mice treated with ofloxacin, a new antimicrobial drug.
Ofloxacin (OFLX) in a single dose (250 or 2500 mg/kg) or 5 consecutive daily doses (125 or 1250 mg/kg) produced no dominant lethal mutational effects in male BDF1 strain mice during an 8-week mating schedule. Methyl methanesulfonate (MMS), used as a positive control, produced dominant lethal mutations within 1-3 weeks of mating.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000235:genetics; D005799:Genes, Dominant; D005804:Genes, Lethal; D008098:Litter Size / Q000187:drug effects; D008297:Male; D051379:Mice; D009154:Mutation; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D013094:Spermatozoa / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin