The single-dose pharmacokinetics of 5-epi-sisomicin (Sch 22591) in human volunteers.
5-epi-sisomicin was given as a single 1 mg/kg intramuscular injection to six adult male volunteers. No adverse effects were observed and the pharmacology was very similar to that of sisomicin. The extended spectrum of 5-epi-sisomicin and its enhanced antipseudomonal activity prompt further clinical evaluation of this agent.
D000328:Adult; D005260:Female; D006801:Humans; D007536:Isomerism; D007700:Kinetics; D008657:Metabolic Clearance Rate; D012853:Sisomicin / Q000097:blood / Q000378:metabolism* / Q000652:urine / Q000031:analogs & derivatives
C015852:pentisomicin; D012853:Sisomicin