Cardiotoxic effects of adriamycin and mitochondrial oxidation in rat cardiac tissue.
Rats were subjected to chronic treatment with adriamycin (ADR). Significant alterations of ECG tracings were induced, starting from the third week of treatment. These alterations were related to mitochondrial damage of the heart tissue. A decrease of respiration rate in phosphorylating conditions was observed in isolated organelles over a period of three weeks. Meanwhile, adriamycinol (ADRol) concentration in heart extracts increased during chronic treatment.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000097:blood / Q000633:toxicity*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains
D004317:Doxorubicin; C010013:adriamycinol