Platelet 3H-imipramine binding in pregnancy and the puerperium.
Platelet 3H-imipramine binding was examined in a cross-sectional study of 70 Caucasian women in pregnancy and the early post-partum period, and in 23 nonpregnant women of childbearing age. Mood was also assessed in the pregnancy and post-partum sample. No significant differences in number of binding sites (Bmax) were found, but an increase in the equilibrium dissociation constant (Kd) was demonstrated at 5-7 days post-partum.
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D004644:Emotions / Q000502:physiology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000378:metabolism*; D049590:Postpartum Period; D011247:Pregnancy; D014316:Tritium
D014316:Tritium; D007099:Imipramine