Deficiency of the contact phase of intrinsic coagulation in a horse.
A 16-year-old gelding was examined because of weight loss, inappetence, and intermittent fever of 2 months' duration. Preliminary laboratory findings revealed anemia, hypoproteinemia, thrombocytopenia, and prolongation of the activated partial thromboplastin time. A deficiency or inhibition of coagulation factor XI, factor XII, or high molecular weight kininogen was diagnosed. This defect was not associated with a bleeding diathesis, but should be considered as a cause of prolongation of the activated partial thromboplastin time.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood / Q000662:veterinary*; D003937:Diagnosis, Differential; D006734:Horse Diseases / Q000175:diagnosis*; D006736:Horses; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011288:Prekallikrein / Q000032:analysis
D011288:Prekallikrein