Simultaneous simulation of two different concentration time curves in vitro.
A model for in-vitro simultaneous simulation of two different patterns of pharmacokinetic parameters was developed. In the first compartment the initial concentration simulates that seen after intravenous infusion or bolus injection and the antibiotic is diluted at a constant rate. In the second compartment the concentration rises from zero to a maximum of 1/4 the maximum of the first concentration. From this second compartment the drug is diluted at a slower rate.
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
D000900:Anti-Bacterial Agents; D015281:Cefmenoxime; D002439:Cefotaxime