[Clinico-electrophysiologic studies on the action of the anti-arrhythmic substance 3-carbethoxyamino-5-dimethylamino-acetyl-10,11-dihydro-5H- dibenz[b,f]azepine hydrochloride (Bonnecor, AWD 19-166, GS 015)].
The effects of the new antiarrhythmic drug 3-carbethoxy-amino-5-dimethyl-amino-acetyl-iminodibenzyl-hydroc hlorid (Bonnecor) (B.) were investigated by means of clinical-electrophysiologic methods (His-bundle electrography, programmed electrical stimulation) in 11 patients with normal cardiac output and paroxysmal supraventricular tachycardias. In a maximal dosage of 0.24 mg/kg body mass. B. affects several compartments of the impulse initiation and conduction. B. has positive chronotropic actions on the sinus node automaticity, negative dromotropic effects on the sinu-atrial, intraatrial, AV nodal and intraventricular conduction and finally negative bathmotropic actions on the myocardium of the atria and ventricles. B. suppress the artificial induction of paroxysmal supraventricular tachycardias in patients with AV nodal reentry. These results help to recognize indications (supraventricular and ventricular premature beats or tachycardias) and contraindications (sick sinus syndrome, atrio-ventricular block of higher degreé and bifascicular blocks).
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002036:Bundle of His / Q000187:drug effects; D003984:Dibenzazepines / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011690:Purkinje Fibers / Q000187:drug effects; D012849:Sinoatrial Node / Q000187:drug effects; D013610:Tachycardia / Q000188:drug therapy* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine
Klinisch-elektrophysiologische Untersuchungen zur Wirkung der antiarrhythmischen Substanz 3-Carbethoxyamino-5-dimethylamino-acetyl-10,11- dihydro-5H-dibenz[b,f]azepinhydrochlorid (Bonnecor, AWD 19-166, GS 015).