Single-dose pharmacokinetic study of 13-cis-retinoic acid in man.
A pharmacokinetic study of 13-cis-retinoic acid was performed in nine patients following administration of a single oral dose of 80 mg. An average lag time of 1.2 hours was observed, followed by fast absorption, with a mean half-life of 0.5 hour. Peak plasmatic concentration of 733 ng/ml occurred at 2.3 hours. The disposition profile showed a rapid distribution half-life of 1.3 hours and a terminal elimination half-life of 24.7 hours. No 13-cis-retinoic acid was detected unchanged in urine. An important interpatient variability was noted.
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid; D004341:Drug Evaluation; D006207:Half-Life; D006258:Head and Neck Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D015474:Isotretinoin; D007700:Kinetics; D008297:Male; D014212:Tretinoin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
D014212:Tretinoin; D015474:Isotretinoin