Relation between 67Ga uptake and the stage of inflammation induced by turpentine oil in rats.
For the establishment of the experimental system to judge easily the effect of anti-inflammatory drug, 67Ga-citrate was used. The weight of granuloma tissues induced by inflammable agent, turpentine oil, gradually increased and reached a maximum at 6 days after the administration of turpentine oil. Gallium-67 accumulation in the inflammatory lesions showed also a maximum at 6 days after that. Both patterns were closely similar each other. These results showed that the processes and/or stages of inflammation could be indicated by the pattern of 67Ga uptake.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005710:Gallium Radioisotopes / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine
D000893:Anti-Inflammatory Agents; D005710:Gallium Radioisotopes; D014425:Turpentine