In-vitro activity of Sch 34343 against anaerobic bacteria.
The in-vitro activity of Sch 34343, was compared with that of imipenem against 226 strains of anaerobic bacteria. Sch 34343 was identical in activity to imipenem, inhibiting 99.5% of the organisms tested at 16 mg/l (the breakpoint for both drugs). Imipenem was slightly more active than Sch 34343 against Bacteroides, Fusobacterium and Veillonella, although both drugs inhibited all organisms in these groups below breakpoint levels.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D001441:Bacteroides fragilis / Q000187:drug effects; D015378:Imipenem; D007769:Lactams; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007769:Lactams; D013845:Thienamycins; D015378:Imipenem; C044617:Sch 34343