Clearance of glucose and sucrose from the saliva of human subjects.
The ability of 20 healthy people to clear test solutions of sucrose (0.73 M) and glucose (1.4 M) from the mouth was examined. Both sugars were cleared within 20 min in a two-step manner. Rapid clearance occurred between 0 and 6 min; much slower clearance occurred thereafter. It took 7.2 min with glucose and 6.3 min with sucrose for the saliva-sugar concentration to fall to 1 mg/ml. Salivary flow, stimulated during sugar exposure, decreased in a two-step pattern similar to sugar clearance. Evidently, clearance was dependent on the rate of flow of saliva which took about 1 h to return to its resting flow level. Comparison of the pattern of sugar clearance to the Stephan curve (the rapid pH fall followed by a slow pH rise seen after rinsing with sugar solutions) indicated that the pH-fall phase of the curve occurs during the initial period of rapid sugar clearance and salivary flow, and the pH-rise phase occurs during the subsequent period of slower clearance and slow saliva flow. Comparison with the data of Swenander-Lanke (1957) [Acta odont. scand. 15, 3-156], indicated that the clearance of sugar solutions also reflects the clearance of sugar-containing solid foods from the mouth.
D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013395:Sucrose / Q000378:metabolism* / Q000494:pharmacology
D013395:Sucrose; D005947:Glucose