Clotting activities and antigen concentrations of contact factors in kidney disease.
Factor XII, prekallikrein (PK) and high molecular weight kininogen (HMWK) clotting activities and antigen concentrations in kidney disease patients were studied. Chronic hemodialysis led to a reduction of F XII, PK and HMWK clotting activities. F XII and PK antigen levels were also low. In contrast, the HMWK antigen was normal with respect to concentration as well as electrophoretic migration behaviour on 2 D-immunelectrophoresis. In kidney transplant recipients more than three month after the transplantation, we found an increased of F XII and PK clotting activities, which appeared to depend on the time elapsed since the operation. However, the antigen levels remained normal. The group of chronic kidney disease patients not requiring hemodialysis exhibited normal mean values of all three clotting activities as well as normal F XII and HMWK antigen levels. The PK antigen was reduced. However, a separate evaluation of F XII clotting activities (F XII:C) in patients with glomerular nephritis showed elevated F XII:C which correlated with the BUN values. During acute processes of the kidney disease we observed very high PK clotting activities, which normalized with stabilization of the patients. Our results show that the contact phase coagulation factors behave abnormally in certain kidney disease patients.
D001777:Blood Coagulation; D005174:Factor XII / Q000097:blood*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007165:Immunosuppression Therapy; D007610:Kallikreins / Q000097:blood*; D007674:Kidney Diseases / Q000097:blood*; D007704:Kininogens / Q000097:blood*; D011288:Prekallikrein / Q000097:blood*
D007704:Kininogens; D005174:Factor XII; D011288:Prekallikrein; D007610:Kallikreins