[Potentiation of the radiosensitizing effect of metronidazole using whole-body drug-induced hyperthermia].
The total drug hyperthermia in the presence of metronidazole administration improves radiotherapeutic results in Pliss lymphosarcoma: tumor growth inhibition increases by 12.7-18.5%, tumor regression by 30.6-38.9%. A dose of 100 mg/kg of metronidazole combined with irradiation in the presence of moderate hyperthermia produces even a more noticeable radiosensitizing effect than a dose of 700 mg/kg without hyperthermia. A possibility of quite a high level of tumor radiosensitization with lower doses of metronidazole without toxic manifestations of the body was shown.
D000818:Animals; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy*; D008795:Metronidazole / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D013444:Sulfisoxazole / Q000627:therapeutic use*
D008795:Metronidazole; D013444:Sulfisoxazole
Usilenie radiosensibiliziruiushchego éffekta metronidazola pri pomoshchi obshcheĭ medikamentoznom gipertermii.