[Conformation of dinucleoside phosphates: the conformation encoding hypothesis].
The temperature dependence of the spin-lattice relaxation rate of nucleic bases protones and HI' of ApA, ApC, CpA and CpC (D2O, pH 7) were measured. The possible closed conformers of these dinucleoside phosphates (DNP) were computed by atom-atom potential method. On the basis of conformational calculation and experimental data the composition of closed state was determined. Besides the right-handed "canonic" conformers, the "non-canonic" right- and left-handed conformers were shown to be present in the solution of all DNP studied. It is important to note that, "canonic" conformers of DNP studied being equally probable, the possibility of the realization of "non-canonic" conformers is determined by the nucleotide sequence. It may be expected that different nucleotide sequences have unique "non-canonic" conformations. That type of dependence of the spatial organization of polynucleotides on its nucleotide sequence we call "the conformational encoding".
D000241:Adenosine / Q000031:analogs & derivatives*; D000249:Adenosine Monophosphate / Q000031:analogs & derivatives*; D003562:Cytidine / Q000031:analogs & derivatives*; D003568:Cytidine Monophosphate / Q000031:analogs & derivatives; D003597:Cytosine Nucleotides; D015226:Dinucleoside Phosphates; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D013816:Thermodynamics
D003597:Cytosine Nucleotides; D015226:Dinucleoside Phosphates; C013907:cytidylyl adenosine; C015101:cytidylyl-(3'-5')-cytidine; C026520:adenosine monophosphate-adenosine; D000249:Adenosine Monophosphate; C013797:adenylyl cytidine; D003562:Cytidine; D003568:Cytidine Monophosphate; D000241:Adenosine
Konformatsiia dinukleozidfosfatov: gipoteza konformatsionnogo kodirovaniia.