Zinc and vascular reactivity in rat mesenteric vessels: possible altered dihomo-gamma-linolenic acid metabolism in spontaneously hypertensive rats.
Zinc at a concentration of 0.4 microgram/ml potentiated pressor responses to norepinephrine in isolated perfused mesenteric vessels of SHR and WKY. At a higher concentration, 3.2 micrograms/ml, it inhibited responses to norepinephrine in WKY but produced no such inhibition in SHR. However, a transient potentiation was observed in SHR with the higher concentration. Pressor responses to potassium in WKY were not affected by zinc at either concentration. In SHR, however, the higher dose of zinc inhibited pressor responses to potassium. The low dose had no effect. Since effects of zinc may be mediated by release of DGLA, we suggest that in SHR DGLA release may be impaired.
D015126:8,11,14-Eicosatrienoic Acid / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004357:Drug Synergism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D015032:Zinc / Q000494:pharmacology*
D005231:Fatty Acids, Unsaturated; D015126:8,11,14-Eicosatrienoic Acid; D015032:Zinc; D011188:Potassium; D009638:Norepinephrine