Mantle irradiation of the major salivary glands.
Radiation given to the mantle field for treatment of Hodgkin's disease impinges on the submandibular and parotid glands at levels that have been both measured and calculated to be the complete tumor dose. This dosage is above the level of irradiation that has been shown to cause partial or complete loss of salivary gland function.
D001835:Body Weight; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005373:Film Dosimetry; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D010306:Parotid Gland / Q000378:metabolism / Q000528:radiation effects; D011879:Radiotherapy Dosage; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000378:metabolism / Q000528:radiation effects*; D013363:Submandibular Gland / Q000378:metabolism / Q000528:radiation effects