Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4.
The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450 gene family (P1-450 and P3-450 in the C57BL/6N mouse) has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster X mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450 and P3-450 full-length cDNA clones. Hamster P-450 gene fragments (6.0 and 7.4 kb) were assigned to Chinese hamster chromosome 4. These data are consistent with linkage conservation among these two P-450 sequences and four other loci on mouse chromosome 9 that map to hamster chromosome 4.
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae / Q000235:genetics*; D003412:Cricetulus / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004790:Enzyme Induction / Q000187:drug effects; D005347:Fibroblasts / Q000201:enzymology; D005796:Genes; D006822:Hybrid Cells / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D013045:Species Specificity; D013154:Spleen
D000072317:Polychlorinated Dibenzodioxins; D004247:DNA; D003577:Cytochrome P-450 Enzyme System