Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus).
Genetic analysis of backcross progeny from previously characterized rat inbred strains revealed that the biochemical marker Lap-1 is localized in linkage group I (LG I). Lap-1 codes for leucine arylaminopeptidase (EC 3.4.11). The distances of Lap-1 to c, RT6, and Hbb, based on recombination frequencies, are 3.1 +/- 1.5, 8.3 +/- 4.0, and 11.4 +/- 2.8 cM, respectively. Acon-1 codes for aconitase (EC 4.2.1.3). The calculated distances of Acon-1 to c and Hbb are 30.1 +/- 5.0 and 36.1 +/- 5.3 cM, respectively. This suggests that Acon-1 is also in LG I, but the observed high frequency of double crossovers requires further confirmation of this linkage. Ahd-2, Es-6, and Gdc-1 are linked neither to markers of LG I nor to one another.
D000154:Aconitate Hydratase / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000818:Animals; D004950:Esterases / Q000235:genetics; D005914:Globins / Q000235:genetics; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics; D007931:Leucyl Aminopeptidase / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*
D005914:Globins; D005993:Glycerolphosphate Dehydrogenase; D000444:Aldehyde Dehydrogenase; D004950:Esterases; D007931:Leucyl Aminopeptidase; D000154:Aconitate Hydratase