Philadelphia-chromosome-negative chronic myelogenous leukemia with lymphoid stem cell blastic transformation.
A patient is described who had blastic transformation of Ph1 negative chronic myelogenous leukemia (Ph1 - CML). Characterization of the leukemic cells revealed a population with a lymphoid stem cell phenotype (cALL-, TdT+, Ia+, cIgM-). This particular phenotype may be responsible for the refractoriness to vincristine and prednisone and the rapid downhill course.
D002471:Cell Transformation, Neoplastic; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood* / Q000235:genetics; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells