Organ tolerance of non-steroidal anti-inflammatory drugs: effect on liver cells.
Experimental studies in mice and in rats showed the good tolerance of a new non-steroidal anti-inflammatory drug, flunoxaprofen, by normal and CCl4 damaged liver. The activity of an enzyme-inducing drug, such as phenobarbital, showed a greater increase after pretreatment with indomethacin than with flunoxaprofen or benoxaprofen. High doses of benoxaprofen and indomethacin significantly decreased bromosulphonphthalein excretion in rats with normal or CCl4 damaged liver; the effect was not observed with flunoxaprofen administered at the same dose as benoxaprofen. Moreover, benoxaprofen and indomethacin but not flunoxaprofen induced a significant increase of some serum liver enzymes in CCl4 poisoned rats.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D001583:Benzoxazoles / Q000633:toxicity; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D007213:Indomethacin / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000378:metabolism; D011422:Propionates / Q000633:toxicity; D051381:Rats; D013448:Sulfobromophthalein / Q000097:blood; D014166:Transferases / Q000097:blood
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D011422:Propionates; D013448:Sulfobromophthalein; C011677:benoxaprofen; D014166:Transferases; D010424:Pentobarbital; C045356:flunoxaprofen; D007213:Indomethacin