Comparison of the effects of neuropeptide Y and adrenergic transmitters on LH release and food intake in male rats.
In view of the recent demonstrations that Neuropeptide Y (NPY) and adrenergic transmitters coexist in neurons of the rat brain, we have compared the effects of intraventricular (Ivt) injections of NPY and catecholamines on LH release and food intake in intact male rats. Of the three catecholamines, dopamine (DA), norepinephrine (NE) and epinephrine (E), only E (5.3 micrograms or 15.9 micrograms/rat) significantly stimulated LH release, although NE and E (5.3 micrograms/rat) were equally effective in eliciting food intake in satiated rats. Ivt administration of 10 micrograms NPY significantly stimulated LH release, whereas either lower (0.5 or 2 micrograms/rat) or higher (25 micrograms/rat) doses were ineffective. In contrast, NPY at doses of 0.5 - 10 micrograms/rat increased cumulative food intake in a dose-related fashion. These findings present preliminary evidence of the physiological correlates of the neuronal coexistence of adrenergic transmitters and NPY in the brain and raise the possibility that NPY may normally act either independently, in concert with or via adrenergic systems to evoke LH release and feeding responses in the rat.
D000818:Animals; D002395:Catecholamines / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects; D007276:Injections, Intraventricular; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009478:Neuropeptide Y; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002395:Catecholamines; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D007986:Luteinizing Hormone; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine