Peptide YY: metabolism and effect on pancreatic secretion in dogs.
Peptide YY is an ileocolonic peptide that inhibits meal-stimulated pancreatic secretion when infused in a dose of 400 pmol/kg X h. In this study pancreatic secretion was monitored in response to increasing doses of secretin or cholecystokinin-octapeptide (62.5, 125, 250, and 500 ng/kg X h) during the simultaneous infusion of either saline or peptide YY (400 pmol/kg X h). Peptide YY significantly (p less than 0.05) inhibited the secretory response to the three lowest doses of each pancreatic secretogogue, reducing the bicarbonate response to the 62.5-ng/kg X h dose of secretin by 86% +/- 6% and the protein response to the same dose of cholecystokinin by 57% +/- 16%. In the second limb of the study, the half-life of peptide YY (11.7 +/- 21 min) and the metabolic clearance rate (13.8 +/- 1.6 ml/kg X min) were found to be similar to those of other gastrointestinal hormones. We conclude that inhibition of meal-stimulated pancreatic secretion by peptide YY can be explained by its ability to decrease the responsiveness of the pancreas to endogenous secretogogues.
D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors; D004285:Dogs; D005768:Gastrointestinal Hormones / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D006207:Half-Life; D007263:Infusions, Parenteral; D008657:Metabolic Clearance Rate; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D019894:Peptide YY; D010455:Peptides / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D011863:Radioimmunoassay; D012633:Secretin / Q000037:antagonists & inhibitors
D005768:Gastrointestinal Hormones; D010455:Peptides; D019894:Peptide YY; D012633:Secretin; D002766:Cholecystokinin