Diffuse mandibular enlargement.
Paget's disease of the jaw has the following characteristics: slow progression of jaw enlargement; bilateral jaw involvement; often polyostotic, but not generalized skeletal disease; diffuse, irregular radiopaque areas of the jaw; elevated serum alkaline phosphatase level; and a biopsy specimen showing thick, irregular bone trabeculae with a mosaic pattern of reversal lines and numerous osteoblasts and osteoclasts in a fibrovascular stroma. Management of a patient with Paget's disease of bone usually is carried out by treating the symptoms of the disease as they arise. Bone can be removed for esthetic reasons when needed.
D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000473:pathology*; D011877:Radionuclide Imaging; D012008:Recurrence