Functional and anatomic recovery in the monkey brain following excision of fetal encephalocele.
Teratogen-induced herniation of the occipital lobes (encephalocele) in monkey fetuses was repaired by amputation and cranioplasty in utero or postnatally. The in utero-treated animals had normal vision, CT scans indicated normal brain density, and autoradiographic visualization of the striate cortex by the [14C]-2-deoxyglucose mapping revealed almost complete functional and anatomic recovery. The animals treated postnatally were blind, and exhibited significant structural deficit in the operated area.
D000367:Age Factors; D000818:Animals; D004677:Encephalocele / Q000139:chemically induced / Q000601:surgery*; D005333:Fetus / Q000601:surgery*; D005865:Gestational Age; D008253:Macaca mulatta; D009473:Neuronal Plasticity; D014222:Triamcinolone Acetonide; D014793:Visual Cortex; D014945:Wound Healing
D014222:Triamcinolone Acetonide