Osteosarcoma with multiple intramuscular metastases. A case report.
A 21-year-old man with an osteosarcoma in the proximal tibia was treated by amputation, radio- and chemotherapy. Besides pulmonary metastases, intramuscular metastases repeatedly developed. Cell culture studies of pulmonary and muscular tumors showed different sensitivity patterns for cytostatic drugs; the therapy may have selected different subpopulations of the primary tumor.
D000328:Adult; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology*; D013977:Tibia