[Studies of the possibility of repeated use of capillary dialyzers. I. Renovation method and the evaluation of biological reactivity].
A method devised by the authors of renovation of capillary dialyzers, after rinsing the blood and the liquid systems of the dialyzers is discussed. After rising the blood and the liquid systems of the dialyzers by water at 2 atm.--water being conditioned by the apparatus for reverse osmosis--in the liquid system overpressure of 2 atm was produced by water, the by 0.5% solution of sodium hypochlorite. After 2-3 minutes sodium hypochlorite was rinsed out and both systems were filled in by 1-2% formaldehyde solution. Immediately before using the dialyzer in the same patient the fluid system was rinsed with conditioned water, and the blood system with 21 of sterile distilled water and with 41 of 0.9% NaCl solution. In order to facilitate the renovation process a semi-automatic apparatus was designed, which makes it possible to renovate two dialyzers at once. This method makes it possible to use 80% capillary dialyzers four times with lateral input of the blood system, and four times 100% ones with central input. Experiments on animals and clinical observations and bacteriological studies shoved that the renovation process was atoxic, apyrogenic and sterile. No damage of capillaries and no reactions in subsequent use in patients under dialysis were observed.
D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control; D002482:Cellulose / Q000031:analogs & derivatives*; D004866:Equipment Contamination; D004869:Equipment Safety; D005557:Formaldehyde / Q000494:pharmacology; D006801:Humans; D006874:Hydrostatic Pressure; D007688:Kidneys, Artificial; D051379:Mice; D011817:Rabbits; D018805:Sepsis / Q000517:prevention & control; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013242:Sterilization / Q000379:methods*
D005557:Formaldehyde; D002482:Cellulose; C009865:cuprammonium cellulose; D012973:Sodium Hypochlorite
Badania nad mozliwościa wielokrotnego uzycia dializatorów kapilarnych. Cześć I. Metoda renowacji i ocena odczynowości biologicznej.