Defective immunocompetence in otitis-prone young children.
In a prospective study highly otitis-prone children were found to have significantly lower levels of IgG 2 at 12 and 32 months of age compared to healthy age matched controls. As a confirmation of these results the same otitis prone children had significantly lower activity compared to healthy children with regard to specific antipneumococcal antibody activity of both the IgG 1 and IgG 2 subclasses. These findings support the concept that otitis proneness is partly due to a defective immunocompetence.
D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000032:analysis; D006801:Humans; D007121:Immunocompetence; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification; D007223:Infant; D010033:Otitis Media / Q000276:immunology*; D011446:Prospective Studies; D012008:Recurrence; D013296:Streptococcus pneumoniae / Q000276:immunology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G