Sialylated Lea blood group substances detected by the monoclonal antibody Ca 19-9 in human seminal plasma and other organs.
The glycoprotein fractions of human seminal plasma, amniotic fluid, urine, human saliva and human gastric juice have been found to contain sialyl-Lea blood group substance, an antigen and which is known to function as a tumor-marker in human pancreatic and gastrointestinal cancer (Ca 19-9). Tumor-associated carbohydrate structures may well occur in large amounts both in normal tissue and in secretions as organ-specific markers. In human seminal plasma typical variations have been found in relationship to the Lewis blood group of the donor. Accordingly, the Ca 19-9 antigen can be regarded as a marker of the main glycoprotein fraction of human seminal plasma, which could be useful as a tool for clinical investigations.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015295:Antigens, Tumor-Associated, Carbohydrate; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008297:Male; D009928:Organ Specificity; D012661:Semen / Q000276:immunology*; D014566:Urogenital System / Q000276:immunology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D006023:Glycoproteins; D007983:Lewis Blood Group Antigens