The estimation of recurrence risks in monogenic disorders using flanking marker loci.
A method is presented of calculating recurrence risks at a disease locus where there is information from flanking marker loci. This method uses output from the computer programme LIPED. Information from carrier detection tests and mutation at the disease locus can be taken into account in certain pedigrees.
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D003201:Computers; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D010375:Pedigree; D012008:Recurrence; D012306:Risk; D012984:Software
D005819:Genetic Markers