Effect of hyperthyroidism and its treatment on bone mineral content.
Patients with hyperthyroidism may develop osteopenia associated with fractures; however, there has been no general agreement on the incidence of osteopenia in hyperthyroidism or the recovery of the mineral loss after treatment of hyperthyroidism. We conducted a longitudinal prospective study on the effect of hyperthyroidism and its treatment on bone mineral content (BMC) using photon absorptiometry. We observed that both young and older hyperthyroid patients showed a significantly decreased baseline BMC compared with age- and sex-matched controls. We also observed a slight recovery of BMC in hyperthyroid patients at the two-year interval after a euthyroid state had been achieved. However, the BMC was still much lower than that of controls, and we did not find any significant restoration of BMC following "cure" of hyperthyroidism.
D000328:Adult; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D006111:Graves Disease / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010015:Osteolysis, Essential / Q000378:metabolism / Q000503:physiopathology; D011441:Propylthiouracil / Q000627:therapeutic use; D011446:Prospective Studies; D013974:Thyroxine / Q000627:therapeutic use
D007457:Iodine Radioisotopes; D008903:Minerals; D011441:Propylthiouracil; D013974:Thyroxine; D002118:Calcium