Life span and tumor incidence in rats receiving postradiation treatment with ATP-AET-mexamine mixture.
Rat females were exposed to a single 4.0-Gy gamma-ray dose and treated postradiation with a mixture of ATP-AET-mexamine at daily doses of 24, 12, and 3 mg/kg body wt, respectively, in drinking water throughout the period of their survival. With the radiation dose used, life shortening appeared primarily attributable to nonstochastic effects. The mixture of chemical protectors failed to show modification of long-term radiation effects with regard to either life span or tumor incidence.
D008735:5-Methoxytryptamine / Q000008:administration & dosage; D000255:Adenosine Triphosphate / Q000008:administration & dosage; D000818:Animals; D004359:Drug Therapy, Combination; D005260:Female; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D008735:5-Methoxytryptamine; D000255:Adenosine Triphosphate