Reduction of urinary excretion of PGE2 and 6 keto PGF1 alpha by tiaprofenic acid.
Tiaprofenic acid (Surgam, Cassenne) was administered intravenously to saline-diuretic conscious rats, at doses of 2, 10 and 25 mg kg-1 body weight. Tiaprofenic acid significantly reduced urinary prostaglandin E2 (PGE2) and 6 keto PGF1 alpha excretion, at all three doses employed. The extent of the reduction was similar for both PGE2 and 6 keto PGF1 alpha output; hence no evidence of 'selectivity' (i.e. sparing of PGI2 synthesis) was observed. Tiaprofenic acid was also administered to rats receiving an infusion of 5% dextrose. The dose employed (0.5 or 1 mg kg-1 body weight) was submaximal and elicited reductions in PGE2 output to values still more than 60% of the control period values. In this group of animals, the percentage change in 6 keto PGF1 alpha excretion was again not significantly different from that of PGE2. The maximal extent of reduction in urinary PGE2 excretion with tiaprofenic acid (25 mg kg-1 body weight) was not significantly different from that elicited by indomethacin (10 mg kg-1 body weight), although the time course of the reduction was different.
D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine*; D000818:Animals; D003864:Depression, Chemical; D015232:Dinoprostone; D005947:Glucose / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011422:Propionates / Q000494:pharmacology*; D011458:Prostaglandins E / Q000652:urine*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011422:Propionates; D011458:Prostaglandins E; C021270:tiaprofenic acid; D015121:6-Ketoprostaglandin F1 alpha; D005947:Glucose; D015232:Dinoprostone; D007213:Indomethacin