[Association of autoimmune dementia, Basedow's disease, and Gougerot-Sjögren syndrome].
The authors observed one case of myoclonic dementia reversible with steroid therapy, associated with Grave's disease and Sjögren's syndrome. A circulating IgG fraction was demonstrated reacting specifically with cerebral micro-vessels and which evolved in parallel with the neuro-psychiatric disturbances. These results support the hypothesis of an autoimmune vasculitis causing the dementia. The persistence of abnormalities one year after clinical cure showing an alteration of the blood-brain barrier associated with the appearance of circulating antibodies against the hypophyseal cells, and in view of the predictive value of these antibodies, suggests a possibility of the eventual apparition of an Alzheimer type dementia.
D001327:Autoimmune Diseases; D003704:Dementia / Q000209:etiology* / Q000276:immunology; D006111:Graves Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology; D013963:Thyroid Hormones / Q000276:immunology; D013997:Time Factors
D013963:Thyroid Hormones; D011239:Prednisolone
Association démence "auto-immune", maladie de Basedow, syndrome de Gougerot-Sjögren.