The effect of radiation on the response of dental pulp to operative and endodontic procedures: an experimental study.
Thirty-six 56-day-old male Sprague-Dawley albino rats served as two groups of experimental animals. Group 1 was irradiated with 400 rads delivered as total-body radiation from a cesium source. Group 2 served as the control group and was not irradiated. Three weeks later, the dental microscope was used to facilitate various dental procedures in both groups of animals (cavity preparation filled with zinc oxide-eugenol, pulp exposure capped with zinc oxide-eugenol, and pulp exposure left open). Two animals for each procedure from Groups 1 and 2 were killed at time intervals of 2, 4, and 8 weeks. The results showed that (1) radiation at this dose resulted in a depression of the normal response of the dental pulp to the trauma and infection induced by pulpal exposure, (2) there were no pathologic changes in the untreated molars of the irradiated animals, and (3) the use of the dental microscope greatly facilitated cavity preparation in the molars of rats.
D000818:Animals; D002588:Cesium Radioisotopes; D003737:Dental Cavity Preparation; D003782:Dental Pulp / Q000033:anatomy & histology / Q000166:cytology / Q000528:radiation effects*; D003789:Dental Pulp Exposure; D003790:Dental Pulp Necrosis / Q000473:pathology; D008297:Male; D011671:Pulpitis / Q000473:pathology; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D012390:Root Canal Therapy; D015035:Zinc Oxide-Eugenol Cement / Q000008:administration & dosage
D002588:Cesium Radioisotopes; D015035:Zinc Oxide-Eugenol Cement