[Changes in lectin-induced agglutination of human tumor cells during the process of their reversion].
The concanavalin A-induced agglutination of cultivated cells of human osteosarcoma Sa-4 was studied in the process of their reversion caused by high polar compounds, dimethylsulphoxide (DMSO) and dimethylformamide (DMFA). Primarily lectin induced an expressed ability to agglutination in Sa-4 cells. In the process of tumour cell reversion under the effect of chemical inducers their agglutination decreases. After the DMSO and DMFA removal the osteosarcoma cells return to their initial state showing a high agglutination. Other high-polar compounds (N-methylformamide and dimethylacetamide) induced no reversion of Sa-4 cells and no agglutination of them as well.
D000081:Acetamides / Q000494:pharmacology; D000371:Agglutination / Q000187:drug effects; D003208:Concanavalin A / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003470:Culture Media; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004126:Dimethylformamide / Q000494:pharmacology*; D004347:Drug Interactions; D005559:Formamides / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D012516:Osteosarcoma / Q000473:pathology*
D000081:Acetamides; D003470:Culture Media; D005559:Formamides; D003208:Concanavalin A; D004126:Dimethylformamide; C018595:N-methylacetamide; C002950:methylformamide; D004121:Dimethyl Sulfoxide
Izmeneniia indutsirovannoĭ lektinami aggliutinatsii opukholevykh kletok cheloveka v protsesse ikh reversii.