Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone.
Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.
D000818:Animals; D003622:Dapsone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D007918:Leprosy / Q000188:drug therapy*; D011817:Rabbits
C049355:4,4'-disuccinoylaminodiphenyl sulfone; C049356:4,4'-dibutyrylaminodiphenyl sulfone; D003622:Dapsone