Potent antitumor antibiotic complex: PD 114,759, PD 115,028, PD 119,707, and PD 119,193.
Four novel antitumor antibiotics (PD 114,759, PD 115,028, PD 119,707 and PD 119,193) are produced as a complex by a new species of Actinomadura. The proposed name for the culture is Actinomadura verrucosospora subsp. veractimyces ATCC 39363. The antibiotics are extremely bioactive, with MIC values of less than 0.006 ng/ml against several bacteria and ID50 values of 0.003 approximately 0.107 ng/ml against L1210 leukemia cells in vitro. Antitumor activities vs. P388 leukemia in vivo were observed at doses of 0.313, 0.40, and 0.5 micrograms/kg (daily X 5) for PD 119,707, PD 115,028, and PD 114,759, respectively.
D000192:Actinomycetales / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000494:pharmacology; D001688:Biological Products; D005285:Fermentation; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests
D000903:Antibiotics, Antineoplastic; D001688:Biological Products; C044530:veractamycin A; C044531:veractamycin B; C047325:veractamycin E; C047324:veractamycin D