Norfloxacin penetration into human renal and prostatic tissues.
Concurrent norfloxacin concentrations in serum, kidney, and prostatic tissue were determined in 14 patients. Mean ratios of norfloxacin concentration in tissue over concentration in serum were 6.6 +/- 2.8 for the kidney and 1.7 +/- 0.2 for the prostate samples. The levels were above the MICs of most urinary pathogens.
D000368:Aged; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism*; D014552:Urinary Tract Infections / Q000188:drug therapy
D009643:Norfloxacin