Inhibition of [3H]-thymidine uptake in human gingival fibroblasts by extracts from human dental plaque, oral bacteria of the Streptococcus and Actinomyces species.
Extracts from human dental plaque, Streptococcus mutans, Streptococcus salivarius, Streptococcus faecalis, Streptococcus sanguis, Actinomyces israelli and Actinomyces odontolyticus inhibited [3H]-thymidine uptake by primary human gingival fibroblast cell lines as previous work has shown in respect of HeLa cells. The results show that a variety of oral bacteria, not usually considered to be periodontal pathogens, elaborate factors that adversely affect fibroblasts.
D000190:Actinomyces; D002460:Cell Line; D003773:Dental Plaque / Q000032:analysis*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005881:Gingiva / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D013291:Streptococcus; D013936:Thymidine / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts; D013936:Thymidine