Vitamin K dependent proteins in fetal hemostasis at mid trimester of pregnancy.
The vitamin K dependent coagulation factor activities were measured in 63 normal human fetuses from 19 to 28 weeks of pregnancy. These activities were included between 9 to 28 percent of normal adult levels. Prothrombin antigen, factor IX antigen and protein C were also measured. There is a good correlation between prothrombin procoagulant activity and antigenicity, suggesting that low level of these vitamin K dependent proteins in fetuses is probably a consequence of liver immaturity.
D000941:Antigens / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis*; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis / Q000276:immunology; D005170:Factor X / Q000032:analysis; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006023:Glycoproteins / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011486:Protein C; D011516:Prothrombin / Q000032:analysis; D014812:Vitamin K / Q000502:physiology*
D000941:Antigens; D001779:Blood Coagulation Factors; D006023:Glycoproteins; D011486:Protein C; C042580:factor VII clotting antigen; D014812:Vitamin K; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X