Efficacy and safety of clorsulon used concurrently with ivermectin for control of Fasciola hepatica in Florida beef cattle.
The safety and anthelmintic efficacy of clorsulon (7 mg/kg of body weight, orally) given concurrently with ivermectin (0.2 mg/kg, subcutaneously) for control of Fasciola hepatica were evaluated in 75 crossbred beef cattle. Twenty-three control animals were given only ivermectin. Fluke egg counts were significantly lower (P less than 0.0001) in clorsulon-treated animals by day 14 after treatment than before treatment (base line) and were significantly lower (P less than 0.005) after treatment in clorsulon-treated animals than in controls. There was no significant change in fluke egg counts of controls after treatment. The efficacy of clorsulon in reducing F hepatica egg counts was 99%. Clorsulon showed poor efficacy against paramphistomes. Adverse reactions were not observed.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000469:parasitology / Q000517:prevention & control*; D005243:Feces / Q000469:parasitology; D005260:Female; D005431:Florida; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D012449:Safety; D013424:Sulfanilamides / Q000627:therapeutic use*
D000871:Anthelmintics; D000980:Antiplatyhelmintic Agents; D007783:Lactones; D013424:Sulfanilamides; D007559:Ivermectin; C015675:clorsulon