Complete blockade and attenuation of 5-hydroxytryptamine induced analgesia following NA depletion in rats and mice.
The effect of pretreatment with the noradrenaline neurotoxin, N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4), upon the analgesia induced by various doses of 5-hydroxytryptamine (5-HT) was examined in rats and mice. DSP4 treatment (2 X 50 mg/kg, intraperitoneally) of rats caused a complete blockade of 5-HT induced analgesia in the tail-flick, hot-plate and shock titration tests. DSP4 treatment (1 X 50 mg/kg, intraperitoneally) of mice caused a partial blockade of 5-HT induced analgesia in the hot-plate test, but no significant blockade in the tail-flick test. These results are discussed with regard to serotonergic-noradrenergic interactions and the species discrepancy in nociceptive testing.
D000700:Analgesics / Q000037:antagonists & inhibitors; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism; D004597:Electroshock; D007278:Injections, Spinal; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013045:Species Specificity; D013116:Spinal Cord / Q000378:metabolism
D000700:Analgesics; D001596:Benzylamines; D002395:Catecholamines; D012702:Serotonin Antagonists; D012701:Serotonin; C012102:DSP 4; D009638:Norepinephrine