[Aminooxypropylamine--an effective inhibitor of ornithine decarboxylase in vitro and in vivo].
Hydroxylamine-containing analogues of putrescine and cadaverine have been found effective in inhibiting the mouse liver ornithine decarboxylase, the best among synthesized were 1-aminooxy-3-aminopropane (I50 2.10(-8) M) and 1-aminooxy-4-aminobutane (I50 2.10(-7) M). The inhibitory effect of these substances on the mouse liver ornithine-transaminase and S-adenosylmethionine decarboxylase from E. coli was displayed at concentrations higher by several orders of magnitude, that demonstrated the specificity of the compounds of this type. 1-Aminooxy-3-aminopropane in experiments in vivo suppressed the ornithine decarboxylase activity in mouse liver at 16 mg/kg by 75%, the toxic effect being insignificant.
D000818:Animals; D002082:Butylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D051379:Mice; D065108:Ornithine Decarboxylase Inhibitors; D011437:Propylamines / Q000138:chemical synthesis / Q000494:pharmacology*; D011700:Putrescine / Q000494:pharmacology
D002082:Butylamines; D065108:Ornithine Decarboxylase Inhibitors; D011437:Propylamines; C047901:1-aminooxy-4-aminobutane; C046252:1-aminooxy-3-aminopropane; D011700:Putrescine
Aminooksipropilamin--éffektivnyĭ ingibitor ornitindekarboksilazy in vitro i in vivo.