Combined effects of amantadine and interferon on influenza virus replication in chicken and human embryo trachea organ culture.
Amantadine (greater than or equal to 100 micrograms/ml) treatment of chicken or human trachea organ cultures 6 h before infection inhibited influenza virus replication. Chicken or human leukocyte IFN evoked antiviral resistance in the cells of the homologous organ cultures only at a concentration of 100 U/ml or more. Treatment of organ cultures with combinations of the two substances resulted in an additive effect on influenza virus replication in both chicken and human tissues.
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D004261:DNA Replication / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D009924:Organ Culture Techniques; D014176:Protein Biosynthesis / Q000187:drug effects; D014132:Trachea; D014158:Transcription, Genetic / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D007370:Interferon Type I; D000547:Amantadine