Production of mononuclear cell factor by mononuclear phagocytes from rheumatoid synovial fluid.
Collagenase-and PGE1-stimulating activities (mononuclear cell factor or MCF) have been found in culture supernatants from synovial fluid macrophages (SF-M phi) of patients wih rheumatoid arthritis. The apparent molecular weight of the MCF activity present in SF-M phi supernatants was between 15-20,000 daltons, which is similar to interleukin I. All the SF-M phi supernatants from patients tested showed the MCF activity. Our study presents evidence for MCF production by monocyte-macrophages at the local site of the lesion.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D015232:Dinoprostone; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D015846:Monokines; D010586:Phagocytes / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis; D014176:Protein Biosynthesis; D013582:Synovial Fluid / Q000166:cytology / Q000378:metabolism*
D015846:Monokines; D011458:Prostaglandins E; D015232:Dinoprostone