Ferritin H and L chains are derived from different multigene families.
This paper explores the complexity of human ferritin H and L genes. We show that essentially full-length cDNA clones for human ferritin H and L chains do not cross-hybridize under moderate stringency conditions and present the first comparisons of H and L mRNAs and genes from the same species. Northern blot analyses indicate that the H and L mRNAs each contain about 1100 nucleotides. Subprobe analyses of Southern blots show that both H and L genes exist as multiple gene families. Both the 5' and 3' sequences of the H genes are heterogeneous, whereas the 3' end of the L gene is relatively conserved.
D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005293:Ferritins / Q000235:genetics*; D005796:Genes; D006801:Humans; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis
D012333:RNA, Messenger; D004247:DNA; D005293:Ferritins