Quantitative relationship between T3 and the T-cell antigen receptor on a human leukaemic line.
The T-cell antigen receptor complex consists of an idiotypic molecule, Ti, and T3. We have investigated the relationship between Ti and T3 on a leukaemic line HPB-ALL. This has shown that the two molecules are expressed on the cell surface in equal numbers, and that a similar stoichiometric relationship is seen on sublines of HPB-ALL selected for diminished expression of Ti. Furthermore, the degrees of modulation and rates of resynthesis of Ti and T3 following modulation were very similar, regardless of whether anti-Ti or anti-T3 was used to produce the modulation. This work strongly suggests that the expression of Ti and T3 are under common control.
D000911:Antibodies, Monoclonal / Q000276:immunology; D001666:Binding Sites, Antibody; D002460:Cell Line; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis* / Q000096:biosynthesis; D007945:Leukemia, Lymphoid / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*
D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D011948:Receptors, Antigen, T-Cell