Clinical assessment of sulbenicillin in acute respiratory tract infection.
The effectiveness of sulbenicillin was assessed in the treatment of 15 adults, 12 suffering from bronchopneumonia and three from lobar pneumonia. Six patients had concomitant complications. At a parenteral dose of 2 g twice or thrice daily for at least seven days, all patients became afebrile by the sixth day, and chest X-rays became normal in nine patients and improved in five. It is concluded that sulbenicillin, which was well tolerated, is clinically effective in the treatment of severe respiratory tract infections, also in patients with major impairment of their immune response systems.
D000328:Adult; D000368:Aged; D001682:Biological Availability; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000031:analogs & derivatives*; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D013408:Sulbenicillin / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D013408:Sulbenicillin; D010400:Penicillin G