[Acute leukemia secondary to the treatment of multiple sclerosis with chlorambucil].
A new case is reported here of acute myeloid leukemia after chlorambucil therapy for multiple sclerosis. This is the sixth case seen at our institution during the period 1978 to 1984. The leukemogenic potential of the immunosuppressive cytotoxic drugs in patients with multiple sclerosis is emphasized.
D000328:Adult; D000477:Alkylating Agents / Q000009:adverse effects; D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011289:Preleukemia / Q000139:chemically induced; D013997:Time Factors
D000477:Alkylating Agents; D007166:Immunosuppressive Agents; D002699:Chlorambucil
Leucémie aiguë secondaire au traitement de la sclérose en plaque par le chlorambucil.