Prostaglandins involvement in the formation of luteinized unruptured follicles in the cyclic female rat.
The purpose of this investigation was to study the role played by prostaglandins in advanced ovulation and in the formation of luteinized unruptured follicles (LUF) in cyclic female rats. Dose related effects on ovulation were observed in rats given LH on diestrus 2 at 16.30. A significant positive correlation was observed between the number of postovulatory corpora lutea (POCL) and the increasing doses of LH. By contrast the number of LUF was negatively correlated with LH. Indomethacin treatment by 6h30 after administration of an ovulatory LH dose significantly increased the occurrence of LUF at the expense of POCL. Conversely PGF2 alpha when administered by 6h30 after a subovulatory LH stimulation enhanced in a dose dependent manner the number of POCL with respect to the LH treated controls. Under a similar treatment with a subovulatory dose of LH, PGE2 remained without ovulatory effects. The mechanisms of the formation of LUF are discussed on the basis of these results.
D000818:Animals; D004031:Diestrus; D015237:Dinoprost; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology*; D006080:Ovarian Follicle / Q000187:drug effects*; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D011460:Prostaglandins F; D007986:Luteinizing Hormone; D015237:Dinoprost; D015232:Dinoprostone; D007213:Indomethacin