Human ApoB-100 gene resides in the p23----pter region of chromosome 2.
Human apolipoprotein (apo) B-100 is the major apolipoprotein of low density lipoproteins (LDL) and the principal ligand for interaction with the LDL receptor. The gene for apoB-100 has been localized to the p23----pter region of chromosome 2 by filter hybridization analysis with radiolabelled apoB-100 cDNA probes and human-mouse somatic cell hybrids containing chromosome 2 translocations. Other genes at the end of the short arm of chromosome 2 include acid phosphatase, proopiomelanocortin complex, malate dehydrogenase, and N-myc, the latter gene has been previously localized to the same bands (2p23----pter) as the apoB-100 gene. The localization of the apoB-100 gene to the p23----pter region of chromosome 2 completes the genomic organizational relationship of the LDL receptor and the two apolipoprotein ligands for the LDL receptor, apoE and apoB-100; the LDL receptor and apoE having been previously localized to chromosome 19.
D000818:Animals; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000235:genetics*; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D004247:DNA; D004274:DNA, Recombinant; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D004274:DNA, Recombinant; D004247:DNA