Transplantation of human malignant and premalignant skin lesions of epidermis to nude mice.
Lesions of solar keratoses and squamous cell carcinoma maintained their histological appearance and an increased tritiated thymidine autoradiographic labelling index after being grafted on to nude mice. However, the values for their mean epidermal thickness and individual cell size appeared to decrease slightly during the 24-week period of study. As judged by the immunolocalization of involucrin antibodies, the grafts maintained a human epidermal antigenic profile. However, immunolocalization studies with HLA antibodies showed only a patchy positivity in the original premalignant lesions and were negative after grafting. These results indicate the potential value of the nude mouse as a model for studying the progress of premalignant and malignant skin lesions in an immunologically privileged non-human site and further indicate that solar keratoses can be maintained independently of systemic donor influences.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D007642:Keratosis / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011230:Precancerous Conditions / Q000473:pathology; D011498:Protein Precursors / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism
D000906:Antibodies; D006680:HLA Antigens; D011498:Protein Precursors; C032253:involucrin; D013936:Thymidine