Effect of steviol and its structural analogues on glucose production and oxygen uptake in rat renal tubules.
The effect of several natural products of Stevia rebaudiana on glucose production and oxygen uptake in rat renal cortical tubules was investigated. Steviol, isosteviol and glucosilsteviol decreased glucose production and inhibited oxygen uptake. The sweet principle stevioside, and steviolbioside, however, were without effect on gluconeogenesis and oxygen uptake.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000494:pharmacology*; D045786:Diterpenes, Kaurane; D005943:Gluconeogenesis / Q000187:drug effects*; D005960:Glucosides / Q000494:pharmacology; D007684:Kidney Tubules / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000494:pharmacology
D004224:Diterpenes; D045786:Diterpenes, Kaurane; D005960:Glucosides; D013729:Terpenes; C012043:stevioside; C012042:steviol; C044523:glucosilsteviol