Pharmacokinetics of elimination of 6-mercaptopurine in the urine of children with acute lymphoblastic leukemia.
6-Mercaptopurine (6-MP)-induced sodium azide--iodine reaction was adapted for determination of 6-MP in urine of four children treated with single oral doses of the drug in tablets. Open one-compartment body model was assumed, and first-order elimination rate constants (K) and biological half-life times (t0,5) were calculated, and their precision was determined by statistical treatment.
D002648:Child; D002675:Child, Preschool; D006801:Humans; D007700:Kinetics; D007945:Leukemia, Lymphoid / Q000652:urine*; D015122:Mercaptopurine / Q000652:urine*; D013997:Time Factors
D015122:Mercaptopurine