A comparison of Lamicel and prostaglandin E2 vaginal gel for cervical ripening before induction of labor.
The efficiency and safety of Lamicel, a new synthetic cervical ripening agent, were compared with those of intravaginal prostaglandin E2 gel in a group of 80 primigravid women about to undergo induction of labor. Lamicel caused less uterine activity and fetal distress than prostaglandin gel, although the induction-delivery intervals were similar in both groups. More normal deliveries occurred in the Lamicel group than in the prostaglandin group. It is suggested that Lamicel is a useful, efficient preinduction ripening agent that is safer than intravaginal prostaglandin gel.
D001034:Apgar Score; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D002585:Cesarean Section; D036861:Delivery, Obstetric / Q000379:methods; D015232:Dinoprostone; D005260:Female; D005316:Fetal Distress / Q000503:physiopathology; D006801:Humans; D007751:Labor, Induced; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011142:Polyvinyl Alcohol / Q000627:therapeutic use*; D011247:Pregnancy; D011458:Prostaglandins E / Q000627:therapeutic use*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects
D001672:Biocompatible Materials; C034860:Lamicel; D011458:Prostaglandins E; D008278:Magnesium Sulfate; D011142:Polyvinyl Alcohol; D015232:Dinoprostone