Major gangliosides in normal and pathological human thyroids.
The major gangliosides of human thyroids were extracted, purified and then analyzed by gas-liquid chromatography. In normal thyroid, GM3 and GD3 represented about 80% of lipid-bound sialic acid. GM3 contained more than 50% of long-chain fatty acids, whereas GD3 contained mostly short ones. 4D hydroxy sphinganine represented 20% of long-chain base content in both cases. In pathological thyroids (Graves' disease, cancer, toxic adenoma), GM3 represented about 60% of lipid-bound sialic acid; its fatty acid content was mostly short chain fatty acids, as in normal GD3. 4D hydroxy sphinganine proportion was decreased.
D000236:Adenoma / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005732:Gangliosides / Q000032:analysis* / Q000378:metabolism; D006111:Graves Disease / Q000378:metabolism; D006801:Humans; D012794:Sialic Acids / Q000032:analysis; D013959:Thyroid Diseases / Q000378:metabolism*; D013961:Thyroid Gland / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000378:metabolism
D005227:Fatty Acids; D005732:Gangliosides; D012794:Sialic Acids