Differential apomorphine effects.
Two dose levels of apomorphine were used with the tail-flick assay. A low dose of apomorphine significantly increased tail-flick latency, whereas a high dose significantly decreased tail-flick latency. Such differential effects have bearing on the reported complex interaction between the dopamine and endorphin systems in the brain.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D004723:Endorphins / Q000502:physiology*; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D001058:Apomorphine; D004298:Dopamine