Intrathecal orgotein.
During the period 1971-78, 133 intrathecal injections of orgotein or superoxide dismutase have been given, mostly to patients with multiple sclerosis. Evaluation of the effect was deficient but the impression was that of improvement and 45% of the 58 patients with multiple sclerosis requested further intrathecal injections. In one case, intrathecal injections had a good effect against allergic headaches after myelography. Determination of orgotein in samples of cerebrospinal fluid from 16 patients with multiple sclerosis gave remarkable results in that the content of orgotein was significantly lower than the level reported by other investigators.
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008667:Metalloproteins / Q000008:administration & dosage*; D009103:Multiple Sclerosis / Q000188:drug therapy; D013482:Superoxide Dismutase / Q000032:analysis
D000893:Anti-Inflammatory Agents; D008667:Metalloproteins; D013482:Superoxide Dismutase; C005180:orgotein