Pathogenetic mechanisms in experimental gastric stress ulceration.
The studies reviewed suggest that the presence of luminal acid is essential for acute gastric stress ulceration to occur and that acid promotes ulceration by diffusing into the mucosa in an ulcerogenic situation. Disruption of the mucosal barrier by the presence of e.g. intragastric bile salts, aspirin, or ethanol increases the hydrogen ion back diffusion, thereby increasing the susceptibility of the mucosa to ulceration. Such a disruption is presumably needed for development of ulcerations in species with a "tight" gastric mucosa, such as the dog, the pig and man, whereas in species with a "leaky" mucosa, such as the rabbit or rat, ulceration occurs even without these agents. However, the response of the mucosa to hydrogen ions is not uniform. Luminal acidities and rates of hydrogen ion back diffusion that are normally harmless may in certain situations cause severe damage to the mucosa. Thus, the ability of the mucosa to withstand the influxing hydrogen ions is as important as the absolute amount of hydrogen ions diffusing into the mucosa. If the rate of hydrogen ion back diffusion exceeds the ability of the mucosa to dispose of hydrogen ions, acidification of the mucosa occurs, with resultant breakdown of the tissue. The main factors modulating the response of the mucosa to hydrogen ions are availability of bicarbonate in the mucosa and the mucosal blood flow. Bicarbonate contributes to mucosal protection through secretion by the epithelium to form an "alkaline" buffer layer at the epithelial surface, which seems to act as a "firstline" defence mechanism against the influxing hydrogen ions.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001639:Bicarbonates / Q000502:physiology; D002463:Cell Membrane Permeability; D004285:Dogs; D005753:Gastric Mucosa / Q000098:blood supply / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D011817:Rabbits; D012039:Regional Blood Flow; D012771:Shock, Hemorrhagic / Q000150:complications; D013276:Stomach Ulcer / Q000503:physiopathology*; D013312:Stress, Physiological / Q000503:physiopathology*
D001639:Bicarbonates