Saquayamycins, new aquayamycin-group antibiotics.
From the culture broth of Streptomyces nodosus MH190-16F3, four new antibiotics have been isolated, and named saquayamycins A, B, C and D. The compounds are glycosides of aquayamycin, and among aquayamycin-group antibiotics they are most closely related to P-1894B (vineomycin A1). All saquayamycins act on Gram-positive bacteria and inhibit the growth of adriamycin-sensitive and adriamycin-resistant P388 leukemia cells.
D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism*; D000095602:Angucyclines and Angucyclinones
D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; C046893:saquayamycin; D000095602:Angucyclines and Angucyclinones; C100443:saquayamycin B; C100444:saquayamycin C; C100445:saquayamycin D