Role of seminal prostaglandins in male fertility. II. Effects of prostaglandin synthesis inhibition on spermatogenesis in man.
The effect of prostaglandin biosynthesis inhibition has been studied in two groups of infertile oligozoospermic patients with high or normal-low seminal prostaglandin (PG) levels. PGE and 19-OH PGE were assayed by means of a gas chromatographic method and the most important seminal parameters (volume, concentration, motility and morphology of spermatozoa) were evaluated in basal conditions and at the end of indomethacin treatment, at a daily oral dose of 100 mg for thirty days. A drop in prostaglandin levels following indomethacin was observed in both groups of patients but only in the group with high concentrations of prostanoid derivates the prostaglandin inhibition was correlated with a significant improvement in sperm count and motility.
D000328:Adult; D000527:Alprostadil / Q000031:analogs & derivatives*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009845:Oligospermia / Q000378:metabolism*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011458:Prostaglandins E / Q000032:analysis / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D012661:Semen / Q000032:analysis*; D013091:Spermatogenesis / Q000187:drug effects*
D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; C025128:19-hydroxyprostaglandin E1; D000527:Alprostadil; D007213:Indomethacin