Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha.
Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D049673:History, 20th Century; D007700:Kinetics; D008970:Molecular Weight; D009924:Organ Culture Techniques; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D015291:Transforming Growth Factors
D010455:Peptides; D015291:Transforming Growth Factors