Infantile lymphoblastic leukemia with t(4;11) and septate uterus, double cervix, and double vagina: case report and review of the literature.
Translocation between chromosomes 4 and 11 has been associated with an aggressive subtype of acute lymphoblastic leukemia. To date, 32 cases have been reported, 12 of which have been in infants. We report the 13th infantile case and the first associated with a somatic abnormality (septate uterus with double cervix and double vagina).
D000015:Abnormalities, Multiple / Q000235:genetics*; D000208:Acute Disease; D002584:Cervix Uteri / Q000002:abnormalities; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000150:complications / Q000235:genetics*; D014178:Translocation, Genetic; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*