Preparation and characterization of polymerized liposomes.
Each of these classes of polymerizable lipids offers useful approaches to the preparation of polymerized liposomes. The lipid diacetylenes can be very photosensitive and yield highly colored rigid photopolymers. The reaction is sensitive to lipid structure, membrane packing, and temperature; however, the reaction is difficult to drive to completion. High polymer yields (greater than 90%) and a high degree of polymerization (500) are realized with the monofunctional methacryloyl lipids 4 and 5. These liposomes are characterized by multiple polymer chains per liposome and a moderate reduction in membrane permeability to glucose. Further decreases in membrane permeability can be achieved with dienoyl lipids, e.g., 6, which can be cross-linked as well as highly polymerized (greater than 95%). Progress in synthesis of polymerizable lipids has been rapid, and the initial characterization of some of the reported materials provides guidance for future synthetic endeavors.
D000114:Acetylene; D005947:Glucose; D007700:Kinetics; D008081:Liposomes; D010539:Permeability; D010743:Phospholipids; D010777:Photochemistry; D011108:Polymers; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
D008081:Liposomes; D010743:Phospholipids; D011108:Polymers; D005947:Glucose; D000114:Acetylene