Is maximal acid output useful in identifying relapsing duodenal ulcer patients?
In a group of 94 duodenal ulcer patients consecutively studied and followed-up for 1 year, subjects with maximal acid output (M.A.O.) above 60 mmol/hour (mostly heavy-smoking men), were found to relapse more frequently than those with lower M.A.O. values (72.2% versus 27.6%; p less than 0.0005). A significantly higher relapse rate was also detected in patients treated with maintenance dosages of effective antisecretory drugs (cimetidine, ranitidine, pirenzepine) and presenting M.A.O. over 60 mmol/hour. It is yet to be established whether an alternative therapeutic regime may prove effective in preventing ulcer recurrence in patients with gastric hypersecretion.
D000328:Adult; D000368:Aged; D001570:Benzodiazepinones / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine; D011899:Ranitidine / Q000627:therapeutic use; D012008:Recurrence; D012907:Smoking
D001570:Benzodiazepinones; D010890:Pirenzepine; D002927:Cimetidine; D011899:Ranitidine