Extending the applicability of esterases of low enantioselectivity in asymmetric synthesis.
A strategy for expanding the applicability of esterases of low enantioselectivity for asymmetric synthesis is described. This concept is generally applicable to biochemical processes involving enantiotopic group differentiation. Quantitative expressions have been derived to permit the prediction of enantiomeric excess and the optimization of optical and chemical yields.
D055598:Chemical Phenomena; D002621:Chemistry; D004950:Esterases / Q000302:isolation & purification / Q000378:metabolism*; D004952:Esters / Q000138:chemical synthesis; D007700:Kinetics; D008968:Molecular Conformation; D013237:Stereoisomerism
D004952:Esters; D004950:Esterases