Comparison of two sucralfate dosages (2 g twice a day versus 1 g four times a day) in duodenal ulcer healing.
The effects of two dosage regimens of sucralfate, 2 g twice a day (one-half hour before breakfast and at night) and 1 g four times a day (one-half hour before meals and at night), on ulcer healing in 80 patients with endoscopically proved duodenal ulcer were compared. The study was single-blind and endoscopically controlled. Endoscopy was performed after four weeks and, if complete healing was not achieved, after an additional four weeks. Clinical assessment was carried out every two weeks. Seventy-four patients completed the study. After four weeks, the ulcer had healed in 28 of 36 patients (78 percent) who received 2 g of sucralfate twice a day and in 28 of 38 patients (74 percent) who received 1 g of sucralfate four times a day. The cumulative healing rates after eight weeks were 83 percent and 84 percent, respectively. The results suggest that sucralfate given in a dosage of 2 g twice a day is as effective as 1 g four times a day in the short-term treatment of duodenal ulcer.
D000328:Adult; D000535:Aluminum / Q000008:administration & dosage* / Q000009:adverse effects; D000863:Antacids / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D004384:Duodenoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010352:Patient Dropouts; D012008:Recurrence; D012907:Smoking; D013392:Sucralfate
D000863:Antacids; D000897:Anti-Ulcer Agents; D013392:Sucralfate; D000535:Aluminum