The management of severe hypertension with minoxidil in a once-a-day treatment regimen.
We evaluated the antihypertensive efficacy of "once-a-day" minoxidil, given in conjunction with a diuretic and sympatholytic, and the effect of this simple regimen on patient compliance. Twenty-one severely hypertensive patients had their existing antihypertensive regimens changed to a single daily dose of chlorthalidone (50-100 mg) and either nadolol (160 mg) or reserpine (.25 mg) for a 3-week period. After stabilization on these two drugs, a single daily dose of minoxidil (2.5 mg) was added to each patient's regimen. Doses were titrated as necessary to achieve diastolic blood pressures of less than 90 mmHg. After 3 and 6 months of maintenance therapy, blood pressures were measured 24 hours after the previous day's dosing to evaluate the persistence of the antihypertensive effect. Twenty-four-hour blood pressure control was achieved on 76% of these occasions, and on at least one occasion in 90% of the patients. In addition, compliance was excellent.
D000328:Adult; D000368:Aged; D002752:Chlorthalidone / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D004487:Edema / Q000139:chemically induced; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D006983:Hypertrichosis / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D009248:Nadolol; D010349:Patient Compliance; D011412:Propanolamines / Q000627:therapeutic use; D012110:Reserpine / Q000627:therapeutic use; D013997:Time Factors
D011412:Propanolamines; D009248:Nadolol; D008914:Minoxidil; D012110:Reserpine; D003404:Creatinine; D002752:Chlorthalidone