Absorption of iohexol from cerebrospinal fluid to blood: pharmacokinetics in humans.
The absorption of iohexol from the subarachnoid space was studied in 9 patients. Serum concentrations of iohexol were measured for a minimum of 24 hours after injection. Peak serum concentrations were observed after 2.2 (1.7-2.7) hours. The half-life of the subsequent decrease in serum concentrations was 3.4 (2.2-7.9) hours. Concentrations of iohexol in cerebrospinal fluid were 0.29-4.3 mg I/ml 24 hours after injection (7 patients). Serum and cerebrospinal fluid concentrations of iohexol are comparable to those found after intrathecal injection of metrizamide.
D000328:Adult; D001812:Blood-Brain Barrier; D003287:Contrast Media / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007278:Injections, Spinal; D007463:Iodobenzoates / Q000378:metabolism*; D007472:Iohexol; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009192:Myelography; D014283:Triiodobenzoic Acids / Q000378:metabolism*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol