Multinucleated stromal giant cells of the uterine cervix.
We have studied two cases in which numerous, multinucleated giant cells were present as an incidental finding within the superficial stroma of the cervix. The cells exhibited varying degrees of nuclear atypia and resembled some of the cells found within fibroepithelial polyps of the lower female genital tract. Although the pathogenesis of the lesion is unknown, we believe that the lesion is nonneoplastic and probably represents an exaggeration of the nuclear atypia occurring within the superficial stromal cells of the lower female genital tract. These cells may be mistaken for malignant cells on histologic examination.
D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure*; D002584:Cervix Uteri / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014594:Uterine Neoplasms / Q000473:pathology