[Mathematical model of the sarcomagenic action of osteotropic alpha emitters].
A model for osteosarcoma induction by alpha-emitters is proposed which is based on a well-known conception on the mechanisms of radiation-induced cancer, the processes of bone tissue regeneration, and the kinetics of cells subjected to carcinogenic risk. The main mathematical relations of the proposed model are presented. The dose-effect relationship of the model is compared with the epidemiological data available on the development of osteosarcoma in patients affected by long-lived radium isotopes.
D000512:Alpha Particles; D001861:Bone Regeneration / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012516:Osteosarcoma / Q000209:etiology*; D011230:Precancerous Conditions / Q000209:etiology; D011883:Radium / Q000009:adverse effects
D011883:Radium
Matematicheskaia model' sarkomogennogo deĭstviia osteotropmykh al'fa-izluchateleĭ.