Evaluation of a new pharmaceutical form of nimesulide for the treatment of influenza.
In 39 outpatients suffering from a seasonal epidemic influenza, the antipyretic, analgesic and anti-inflammatory activity of nimesulide granules was compared with that of aspirin + vitamin C granules. The drugs were administered b.i.d., dispensed in one-dose sachets containing either 100 mg of nimesulide or 500 mg aspirin + 300 mg vitamin C. The efficacy of the two treatments was comparable: both drugs brought about a rapid complete recovery in all treated patients. However, nimesulide was better tolerated: only one case of slight gastralgia was recorded in the nimesulide group vs the six cases of side-effects complained of in the aspirin + vitamin C group.
D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D013449:Sulfonamides; D001205:Ascorbic Acid; D001241:Aspirin; C012655:nimesulide