Hepatic lipogranulomatosis simulating veno-occlusive disease of the liver.
Two cases of unsuspected veno-occlusive disease of the liver were discovered at autopsy. Nearly all central veins and sublobular venules were occluded by lipogranulomas consisting of lipid-laden macrophages, epithelioid histiocytes, giant cells, fibroblasts, lymphocytes, and deposits of collagen. The process extended into the sublobular hepatic venules. Large hepatic veins were uninvolved. Known causes of veno-occlusive disease were ruled out, and the cause of the present cases is unknown.
D000368:Aged; D003937:Diagnosis, Differential; D006099:Granuloma / Q000378:metabolism / Q000473:pathology*; D006503:Hepatic Veins / Q000473:pathology*; D006801:Humans; D050356:Lipid Metabolism; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000378:metabolism / Q000473:pathology*