Haemodynamics in young normotensive men with familial predisposition to hypertension. Studies on normal and increased salt intake.
Central and peripheral haemodynamics were studied noninvasively (echocardiography, plethysmography) in normotensive young men (mean age 30 years) with (n = 17) (H), and without (n = 15) (C) a positive history of hypertension during normal salt intake and after four weeks of ordinary diet plus 12 g NaCl daily. No changes in blood pressure were noted during the course of the study in either group. After three days of high salt an increased cardiac output and decreased total peripheral resistance was seen in H but not in C. The former might be due to a salt induced volume load occurring in a less distensible venous system. The difference in response disappeared during the course of the study. Both on normal and high salt intake resting resistance and resting vascular tone were significantly higher in H reflecting an increased contractile state of the smooth muscles of the resistance vessels. The increased smooth muscle tone of the resistance vessels and the less distensible venous system in these young men with family history of hypertension might be a genetically determined basis for a future increase in blood pressure.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output / Q000187:drug effects; D004562:Electrocardiography; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D009318:Natriuresis; D010991:Plethysmography; D012965:Sodium Chloride / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D012965:Sodium Chloride