Towards understanding paternal extragenic contributions to early amphibian pattern specification: the axolotl ts-1 gene as a model system.
As a model system for understanding the role sperm extragenic components might play in early embryogenesis the genetics and phenotype of the ts-1 axolotl (Ambystoma mexicanum) mutant gene are reviewed. That mutant gene displays parental effects. It exhibits both maternal (egg-mediated) as well as paternal (sperm-mediated) phenotypic effects. A variety of possible modes of action of the ts-1 gene are reviewed. Comparisons of various precedents to the ts-1 genetic data are made. In addition, novel models which account for the ts-1 phenotypic data are presented.
D000557:Ambystoma / Q000235:genetics*; D000558:Ambystoma mexicanum / Q000235:genetics*; D000818:Animals; D001755:Blastocyst; D002502:Centrioles; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004625:Embryo, Nonmammalian / Q000648:ultrastructure; D005306:Fertilization; D005775:Gastrula; D005796:Genes; D005838:Genotype; D008297:Male; D008854:Microscopy, Electron; D008957:Models, Genetic; D009024:Morphogenesis; D010641:Phenotype; D013094:Spermatozoa; D013696:Temperature