Exogenous hyaluronic acid (Healon) accelerates the healing of experimental myringotomies.
Topical application of hyaluronic acid (Healon) onto the borders of rat tympanic membrane perforations accelerated the rate of wound healing. The closure time was roughly 60% of that of the untreated perforations. Epithelial cells fused with opposing cells slightly in advance of supporting connective tissue and thus bridged the remaining gap. It seems as if hyaluronic acid, topically applied, can serve as a supporting and orienting matrix for the proliferating squamous epithelium.
D000287:Administration, Topical; D000818:Animals; D006820:Hyaluronic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014432:Tympanic Membrane / Q000502:physiology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D006820:Hyaluronic Acid