Studies of peritoneal macrophage function in murine systemic lupus erythematosus. 2. Nature of elevated resident peritoneal cells in NZB and (NZB x NZW)F1 mice.
The numbers of resident peritoneal cells recovered from NZB and (NZB X NZW)F1 hybrid mice, which develop systemic lupus erythematosus (SLE), increased strikingly with age as compared with cells recovered from normal mice. The rise paralleled the onset of anti-DNA antibodies, occurring earlier in females than in males. The increased number of cells was due to an accumulation of medium-sized cells with an indeterminate appearance, but with the functional characteristics and cell markers typical of a macrophage. The unusual cells were esterase, F4/80 and Mac-1 positive, peroxidase, and Alcian blue negative, and were shown on sedimentation velocity separation to be phagocytic for EA and C3 (serum-treated) zymosan; 47-48% of peritoneal cells were Ia positive.
D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001202:Ascitic Fluid / Q000473:pathology; D001323:Autoantibodies / Q000276:immunology; D004247:DNA / Q000276:immunology; D004195:Disease Models, Animal; D004950:Esterases / Q000378:metabolism; D005260:Female; D006579:Heterozygote; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology*; D008262:Macrophage Activation; D008264:Macrophages / Q000473:pathology / Q000502:physiology*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D010544:Peroxidases / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001323:Autoantibodies; D004247:DNA; D010544:Peroxidases; D004950:Esterases