Infantile complete heart block associated with maternal Ro(SS-A) ribonucleoprotein autoantibodies: report of two cases.
Two cases of congenital complete heart block arising during pregnancy were observed in association with a circulating maternal autoantibody to the soluble ribonucleoprotein Ro(SS-A). Neither mother had clinical evidence of Sjögren's syndrome or systemic lupus erythematosus usually associated with anti-Ro. However, both had a previous history of first-trimester abortion and laboratory evidence of autoimmunity, and one gave a history of sialadenitis. Maternal anti-Ro antibodies may be predictive of infantile heart block when present in pregnant women with overt or suspected multisystem autoimmune disease.
D000328:Adult; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006327:Heart Block / Q000151:congenital* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen
D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human