Secondary myelofibrosis in three dogs.
Myelofibrosis was diagnosed in 3 dogs. In each dog, there was evidence of concurrent bone marrow necrosis, suggesting that the myelofibrosis was a secondary change. This suggestion was supported by a lack of dysplastic changes in hematopoietic cells. Bone marrow necrosis in 2 of the dogs may have been the result of widespread malignancy. Reversal of the myelofibrosis in 1 dog suggested that myelofibrosis is not always a terminal disorder.
D000230:Adenocarcinoma / Q000662:veterinary; D000740:Anemia / Q000662:veterinary; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000662:veterinary; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000662:veterinary; D008297:Male; D009336:Necrosis; D009362:Neoplasm Metastasis; D055728:Primary Myelofibrosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*