Two cases of lymphosarcoma in channel catfish exposed to N-methyl-N'-nitro-N-nitrosoguanidine.
Of 158 channel catfish (Ictalurus punctatus) exposed to N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS:70-25-7] in water for 28 days, 2 developed disseminated lymphosarcoma. One fish was necropsied at 12 months and another at 18 months following exposure. Both fish had a massive neoplastic infiltration of the bilateral pairs of head and trunk kidneys from which the neoplastic cells appeared to originate. The neoplastic infiltration was also observed in the following: thymus, gills, oral mucosa, liver, skin, skeletal muscle of head-neck region, and to a lesser extent spleen and bone marrow. This is probably the first report of lymphosarcoma in channel catfish. Although the occurrence of lymphosarcoma in these 2 catfish appeared to be related to exposure to MNNG, the exact role MNNG played in the tumor formation was not determined.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005393:Fish Diseases / Q000139:chemically induced* / Q000473:pathology; D005399:Fishes; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008067:Lipoma / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D014874:Water Pollutants, Chemical / Q000633:toxicity
D014874:Water Pollutants, Chemical; D008769:Methylnitronitrosoguanidine