Clinical sub-groups of multiple sclerosis in relation to HLA: DR alleles as possible markers of disease progression.
We have examined the distribution of HLA antigens in 70 multiple sclerosis (MS) patients divided in three groups defined according to clinical criteria: benign MS, severe MS, cerebellar MS. We have found a significant association between severe MS and HLA-DR2, and between benign MS of more than 15 years of evolution and HLA-DR3. We review previous work along the same line and conclude that the association of HLA antigens with "clinical subgroups of MS" could indicate a genetically based heterogeneity of the disease and offer help in establishing a prognosis.
D002526:Cerebellar Diseases / Q000235:genetics; D005819:Genetic Markers; D006680:HLA Antigens / Q000032:analysis*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011379:Prognosis
D005819:Genetic Markers; D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II