Preliminary studies of urinary hydroxyproline levels in rodents and in smokers.
Groups of rats were exposed to four dilutions of cigarette smoke over a period of our weeks. Compared to the control (untreated) group of animals, the 24-hour hydroxyproline output (relative to creatinine) was lower for all dilutions of smoke and showed a negative dose-response relationship. In human smoking studies, in which groups of 20 male subjects and 20 female subjects were switched between various cigarettes for periods of 2 weeks, hydroxyproline output (relative to creatinine) for each sex did not change with increasing nicotine uptake although the outputs for men and women were significantly different.
D000328:Adult; D000818:Animals; D003367:Cotinine / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000652:urine; D051381:Rats; D012907:Smoking; D014028:Tobacco Smoke Pollution
D014028:Tobacco Smoke Pollution; D009538:Nicotine; D003404:Creatinine; D003367:Cotinine; D006909:Hydroxyproline