Continuous treatment with a combination of estrogen and gestagen--a way of avoiding endometrial stimulation. Clinical experiences with Kliogest.
Nearly 5 years' experience of continuous treatment with a preparation consisting of natural estrogens combined with norethisterone acetate is presented. The effect on both climacteric symptoms and hormonal parameters was good, even though the endometrium remained atrophic or became so. This was the case even when the endometrium was hyperplastic and/or atypical prior to treatment. This treatment appears to be better than those in common use--at least in selected cases.
D001284:Atrophy; D002979:Climacteric / Q000187:drug effects*; D004338:Drug Combinations; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D004958:Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D004964:Estriol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009640:Norethindrone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077563:Norethindrone Acetate
D004338:Drug Combinations; D004958:Estradiol; D000077563:Norethindrone Acetate; D004964:Estriol; D009640:Norethindrone