Comparison of meclofenamate sodium with buffered aspirin and placebo in the treatment of postsurgical dental pain.
The efficacy of meclofenamate sodium (Meclomen) at two different doses was compared with that of buffered aspirin and placebo in the control of postsurgical pain in a double-blind, randomized study of 205 patients. Meclofenamate sodium, 200 mg, was significantly better than meclofenamate sodium, 100 mg, in some efficacy parameters. Both doses of meclofenamate sodium were superior to buffered aspirin in most parameters of efficacy, and more effective than placebo in every parameter.
D000082:Acetaminophen / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D003061:Codeine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008469:Meclofenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010919:Placebos; D013997:Time Factors; D014081:Tooth Extraction / Q000009:adverse effects*; D014095:Tooth, Impacted / Q000601:surgery; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D010919:Placebos; D062367:ortho-Aminobenzoates; D000082:Acetaminophen; D008469:Meclofenamic Acid; D001241:Aspirin; D003061:Codeine