[Dipyridamole as an inhibitor of vaccinia virus replication].
Dipyridamole in concentration of 25 microM inhibited the multiplication of vaccinia virus in about 90% of cells. In the presence of this substance, [3H]-uptake was sharply reduced both in uninfected and infected RK13 cells, while [14C]-uptake was not inhibited incorporation of [3H]-thymidine and [14C]-amino acids into viral particles. The present findings suggest that the antiviral character of dipyridamole is related with the inhibition of the substrate transport through the cell membrane.
D000818:Animals; D000998:Antiviral Agents; D002460:Cell Line; D004176:Dipyridamole / Q000494:pharmacology*; D007668:Kidney / Q000382:microbiology; D011817:Rabbits; D014616:Vaccinia virus / Q000187:drug effects / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D004176:Dipyridamole
Dipiridamol kak ingibitor razmnozheniia virusa vaktsiny.