Plasminogen (PLG): a useful genetic marker for paternity examinations.
The genetically determined polymorphism of plasminogen (PLG) was analyzed by isoelectric focusing on polyacrylamide gels. For analysis neuraminidase-pretreated sera were used. PLG was developed functionally by activation with urokinase and subsequent lysis of casein in an agar overlay. In a random sample of 957 unrelated healthy individuals from Southern Germany, three common phenotypes, PLG1, 2-1, and 2, and five rare variants were found. The allele frequencies were: PLG*1 = 0.7174, PLG*2 = 0.2780, and PLG*Var = 0.0046. The theoretical exclusion rate in cases of disputed paternity is 16.5%.
D000328:Adult; D000483:Alleles; D002648:Child; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005860:Germany, West; D006801:Humans; D008297:Male; D010334:Paternity; D010641:Phenotype; D010958:Plasminogen / Q000235:genetics*; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D010958:Plasminogen