Biopharmaceutical investigation of rectal suppositories. Part 2(1): Pharmaceutical and biological availability of phenobarbital and phenobarbital-sodium.
The influence of the suppository base and drug solubility on the release an absorption of phenobarbital and phenobarbital-sodium from model suppositories was investigated. It was established that the pharmaceutical and biological availability of phenobarbital is higher from a hydrophilic base because of its improved solubility. The rate and the degree of release of phenobarbital-sodium are more significant from lipophilic bases. The bioavailability of two drug forms-phenobarbital and phenobarbital-sodium--is almost equal after rectal and oral administration.
D000818:Animals; D001682:Biological Availability; D005079:Excipients; D007408:Intestinal Absorption; D008954:Models, Biological; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D012007:Rectum / Q000378:metabolism*; D012995:Solubility; D013488:Suppositories
D005079:Excipients; D013488:Suppositories; D010634:Phenobarbital