Do platelets migrate into inflammatory exudates?
Rat platelets and the corresponding rabbit IgG antibodies mixed in polyester sponges implanted under the skin of normal animals caused an enhanced 24-h inflammatory response and a significant increase of prostaglandins in the exudate. These experimental results contrast with those obtained for normal rats implanted with sponges containing only IgG anti-platelet antibodies. The present experiments show that circulating platelets were not concentrated at the inflamed site and can hardly be considered of importance in acute inflammation.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002465:Cell Movement; D007106:Immune Sera; D007074:Immunoglobulin G / Q000502:physiology*; D007249:Inflammation / Q000097:blood*; D051381:Rats
D007106:Immune Sera; D007074:Immunoglobulin G