Inotropic effects of the antiarrhythmic compound Bonnecor (AWD 19-166, GS 015).
The inotropic effects of the new antiarrhythmic compound AWD 19-166 have been studied at constantly driven isolated left atria of guinea pig (weight between 250 and 350 g). AWD 19-166 exerted dose-dependently negative inotropic effects. Half maximum effects were measured at 1.7 mg/l (n = 7). At concentrations higher than 5 mg/l the negative inotropic effects were found to be irreversible.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D003984:Dibenzazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; C048166:tiracizine