Anthelmintic activity of ivermectin against immature gastrointestinal nematodes of sheep.
Twenty-four lambs of mixed breeding with mixed experimental infections of Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, and T colubriformis were allotted to 4 groups. One group (control) was given the vehicle propylene glycol, and the others were given 100, 200, or 300 micrograms of ivermectin/kg of body weight by mouth. Twelve days after treatment, the sheep were necropsied. The compound was greater than 99% effective against immature stages of 4 nematode species at all dosages, except at the 100 micrograms/kg dosage, where efficacy was 96% against H contortus.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010029:Ostertagiasis / Q000188:drug therapy / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D014252:Trichostrongyloidiasis / Q000188:drug therapy* / Q000662:veterinary; D014253:Trichostrongylosis / Q000188:drug therapy / Q000662:veterinary
D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin