Sucralfate and gastric bicarbonate.
The effect of sucralfate treatment (3 g daily for 6 weeks) on gastric HCO3- secretion was investigated in 15 duodenal ulcer patients. After treatment a highly significant (p less than 0.01) increase in gastric bicarbonate output was found. It is suggested that the mode of action of sucralfate includes stimulation of gastric alkaline secretion.
D000328:Adult; D000535:Aluminum / Q000494:pharmacology*; D001639:Bicarbonates / Q000378:metabolism*; D004381:Duodenal Ulcer / Q000503:physiopathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013392:Sucralfate
D001639:Bicarbonates; D013392:Sucralfate; D000535:Aluminum