[Effect of the delta-sleep peptide on erythrocyte membrane function during low-temperature exposure].
3-day effect of low temperature increases the amount of extraerythrocyte hemoglobin by 64% in the blood serum, the activity of glucose-6-phosphatedehydrogenase increasing by 231%. Administration of 6.12 or 18 micrograms/100 g body weight of the delta-sleep peptide (DSIP) induces on change in amount of extraerythrocyte hemoglobin in the blood serum of intact rats. 6 micrograms/100 g DSIP increases the activity of glucose-6-phosphatedehydrogenase by 251.6%; 12 micrograms/100 g-- by 165.6%; 18 micrograms/100 g--by 90.6%. The normalizing effect on the level of extraerythrocyte hemoglobin and activity of glucose-6-phosphatedehydrogenase in low ambient temperature occurs at the dose of DSIP 12 micrograms/100 g body weight. The DSIP stabilizes the erythrocyte membranes in low temperature.
D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D003701:Delta Sleep-Inducing Peptide; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D012621:Seasons; D013312:Stress, Physiological / Q000097:blood; D013997:Time Factors
D006454:Hemoglobins; D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide; D005954:Glucosephosphate Dehydrogenase
Vliianie peptida del'ta-sna na sostoianie membran éritrotsitov pri deĭstvii nizkoĭ temperatury.