[Expression of Fc- and C3-receptors on membranes of blast cells in myeloblastic leukemia and blast crisis of myelocytic leukemia].
The expression of Fc-receptors to immunoglobulins IgG, IgA, IgM, that of FcH-receptor and receptors to C3-components of the complement in peripheral blood blast cells were studied in 11 patients with acute myeloblast leukosis and 10 patients with chronic granulocytic leukemia at the stage of blast transformation. The data obtained show the lower level of differentiation and functional activity of blast cells in patients with acute myeloblast leukemia while in chronic granulocytic leukemia a degree of expression of surface receptor on myeloblasts is close to the data obtained in the study of membrane receptors on promyelocytes and myelocytes of healthy persons.
D000328:Adult; D002462:Cell Membrane / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006098:Granulocytes / Q000276:immunology* / Q000648:ultrastructure; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D066298:In Vitro Techniques; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D011951:Receptors, Complement / Q000032:analysis*; D011961:Receptors, Fc / Q000032:analysis*
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011961:Receptors, Fc
Ekspressiia Fc- i C3-retseptorov na membranakh blastnykh kletok pri ostrom mieloblastnom leĭkoze i blastnom krize khronicheskogo mieloleĭkoza.