Placental transport of hexoses: a comparative study with antipyrine and amino acids.
A comparative study of the transplacental passage of some labelled hexoses, amino acids and antipyrine leads to the following conclusions: The maternal-fetal transfer of D-glucose, which amounted to 90 per cent of antipyrine, is very efficient. D-glucose, 3-O-methylglucose and 2-deoxyglucose, for which equivalent transfers were obtained, appear to share the same carrier system. L-glucose transport occurs by simple diffusion. 3-O-methylglucose did not accumulate in the placental tissue. Similarly, maternal and fetal concentrations of 2-deoxyglucose were nearly at equilibrium. It is concluded that the transport of D-glucose is not concentrative. These observations provide further evidence of a facilitated diffusion process for the transport of D-glucose across the human placental membrane.
D000596:Amino Acids / Q000378:metabolism*; D000983:Antipyrine / Q000378:metabolism*; D001693:Biological Transport, Active; D005260:Female; D005947:Glucose / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010477:Perfusion; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy
D000596:Amino Acids; D006601:Hexoses; D007930:Leucine; D005947:Glucose; D000983:Antipyrine