[Features of the intracellular repair of irradiated keratinocytes].
By means of light and electron microscopy, intracellular reparation has been studied after a local x-ray radiation of the rat paws (7.74 X 10(-1) Ci/kg) using radioprotectors (mexamin, cysteamin, ionol) and other chemical compounds (including membranoprotective ones). Restoration of the intracellular structures after x-ray burns proceeds more slowly and more complexly than reparation of the epidermis as a tissue system. To the slowly repairing intracellular formations belong mitochondria and, especially, internal mitochondrial membrane, as well as intercellular contacts. Under radiation mitochondria increase their volume at the expense of their three-fold swelling. Preliminary treatment of the skin with some of the compounds mentioned above decreases or completely prevents these changes. By means of the membranoactive chemical compounds, as well as by means of the known radioprotectors it is possible essentially to normalize the process of intracellular reparation and physiological regeneration of the ultrastructures, and in some cases, to stimulate reparative processes in them.
D008735:5-Methoxytryptamine / Q000627:therapeutic use; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D003538:Cystamine / Q000627:therapeutic use; D004817:Epidermis / Q000528:radiation effects*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D014945:Wound Healing
D011837:Radiation-Protective Agents; D002084:Butylated Hydroxytoluene; D008735:5-Methoxytryptamine; D003538:Cystamine
Osobennosti vnutrikletochnogo vosstanovleniia obluchennykh keratinotsitov.