Steffimycin C, a new member of the steffimycin anthracyclines. Isolation and structural characterization.
Mother liquors from steffimycin B crystallizations have been processed to yield steffimycin C, a new member of the steffimycin family of anthracyclines. It has been identified, using spectroscopic methods, as 10-deoxysteffimycin B. Steffimycin C has antibacterial activity only against Streptococcus pneumoniae. Whether steffimycin C is a precursor of steffimycin B or a metabolic reduction product is unknown at this time.
D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic; D001419:Bacteria / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004352:Drug Resistance, Microbial; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009279:Naphthacenes / Q000302:isolation & purification / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; C046602:steffimycin C