The effects of sucralfate upon phenytoin absorption in man.
The possible influence of sucralfate on phenytoin absorption was investigated in a double-blind, placebo controlled study. Concomitant administration of 1 g sucralfate reduced the absorption of 300 mg phenytoin capsules by 20% as measured by the area under the curve from 0-48 h. This could be of significance in epileptic patients stabilised on phenytoin in whom sucralfate is used in ulcer treatment.
D000328:Adult; D000535:Aluminum / Q000494:pharmacology*; D001682:Biological Availability; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000378:metabolism*; D013392:Sucralfate
D013392:Sucralfate; D010672:Phenytoin; D000535:Aluminum