Clonal development from a progenitor with restricted differentiative expression in acute lymphoblastic leukemia.
Three patients with acute lymphoblastic leukemia (ALL) and heterozygous for the Mediterranean variant of glucose-6-phosphate dehydrogenase (G6PD) have been investigated with the 2-deoxyglucose-6-phosphate (2dG6P) method to determine the number and type of progenitor cells in which the disease arose. A monoclonal origin was established for the lymphoblasts, while the other hemopoietic cell lines were not involved in the leukemic process.
D002648:Child; D002675:Child, Preschool; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008875:Middle Aged; D014411:Neoplastic Stem Cells; D013234:Stem Cells
D003847:Deoxyglucose; D005954:Glucosephosphate Dehydrogenase