Phagocytosis of unopsonized zymosan by human monocyte-derived macrophages: maturation and inhibition by mannan.
Human monocyte-derived macrophages phagocytosed zymosan in the absence of serum opsonins. The capacity to ingest zymosan developed after the cells were cultured in vitro for 3 days and was inhibited completely by mannan. We conclude that human monocyte-derived macrophages phagocytose unopsonized zymosan predominantly via mannose receptors.
D006801:Humans; D037181:Lectins, C-Type; D008264:Macrophages / Q000187:drug effects* / Q000648:ultrastructure; D008351:Mannans / Q000494:pharmacology*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D009895:Opsonin Proteins / Q000378:metabolism*; D010587:Phagocytosis; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000502:physiology; D015054:Zymosan / Q000276:immunology*
D037181:Lectins, C-Type; D008351:Mannans; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D009895:Opsonin Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D015054:Zymosan