Systemic lupus erythematosus, renal disease, hemodialysis and vitamin A.
Recent studies indicate that clinically-active systemic lupus erythematosus (SLE) is uncommon in patients with end-stage renal disease undergoing long-term hemodialysis. Several lines of indirect evidence suggest that the dialysis procedure itself may be responsible for inducing remission; that SLE could reflect a toxicity reaction to excessive tissue levels of vitamin A; and that remission associated with dialysis may be due to a gradual reduction in vitamin A levels at the sites of SLE activity.
D003276:Contraceptives, Oral; D004032:Diet; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications / Q000628:therapy; D014801:Vitamin A / Q000378:metabolism*
D003276:Contraceptives, Oral; D004967:Estrogens; D014801:Vitamin A