Acute lymphoblastic leukaemia with t(4;11) follows neuroblastoma: a late effect of treatment?
The case presented is of a 7-year-old girl who developed acute lymphoblastic leukaemia (ALL) with t(4;11)(q21;q23) 5 years after the onset of neuroblastoma and 4 months after completing treatment for a first relapse. Consideration is given to the relative importance in this case of genetic factors and chemotherapeutic drugs in the etiology of ALL.
D002648:Child; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology; D010386:Pelvic Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic