A suggested role for polymorphonuclear leukocytes in the perpetuation of periapical disease.
During the course of an investigation of endodontic materials using subcutaneously implanted human roots in rats and guinea pigs, it was noted that in areas of the root canal which had not been reamed polymorphonuclear leukocytes had migrated into the dentinal tubules. It is suggested that irritation of the periapical tissues may be mediated by these polymorphonuclear leukocytes. Therefore, the occlusion of dentinal tubules which may be exposed to periapical exudate may be of prime importance in endodontic treatment.
D000818:Animals; D003804:Dentin / Q000473:pathology; D006168:Guinea Pigs; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D010483:Periapical Diseases / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D012390:Root Canal Therapy / Q000379:methods