Human meningeal sarcoma heterotransplants in Nu/Nu mice treated with L-phenylalanine mustard (L-PAM) and dianhydrogalactitol (DAG).
The clinical characteristics and response to therapy of a patient with meningeal sarcoma, one of four patients over a twenty-five year period at Memorial Sloan-Kettering Cancer Center, are described. The light and electron microscopic characteristics of the primary tumor and as a heterotransplant in nude mice showed minimal differences. The tumor was resistant to conventional chemotherapeutic agents, both in the patient, in vitro as a cell culture and ex vivo as a heterotransplant. Only a combination of L-phenylalanine mustard and dianhydrogalactitol produced a limited response in both the patient and the mice. This combination may have some utility in future cases.
D000293:Adolescent; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001855:Bone Marrow Diseases / Q000188:drug therapy; D002460:Cell Line; D003961:Dianhydrogalactitol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D008854:Microscopy, Electron; D012509:Sarcoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D013997:Time Factors
D003961:Dianhydrogalactitol; D008558:Melphalan