[Prostaglandin synthesis by dispersed cells from the submandibular gland of the rat. Effect of pH and calcium].
Qualitative study by HPLC of PGs synthesis by rat sub-maxillary glands cells shows that PGE2 and PGF2 alpha are synthetized predominantly. PGF2 alpha synthesis is essentially related to extracellular ionic concentration of H+ and Ca++ suggesting that the activation of phospholipase A2 or C is more important than the concentration of other enzymes such as 9 intracytoplasmic ceto reductase. Modulation of PGs synthesis by sub-maxillary gland cells by extra cellular factors suggests a possible interaction between hormones (angiotensine II, catecholamines) and phospholipase A2 or C of the cell membrane of these cells.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D015237:Dinoprost; D015232:Dinoprostone; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone; D002118:Calcium; D007213:Indomethacin
Synthèse des prostaglandines par les cellules dispersées de glande sous-maxillaire de rat. Effet du pH et du calcium.