Association of anthracycline derivatives with DNA: a fluorescence study.
The DNA affinity for 26 anthracycline derivatives was studied by the quenching fluorescence technique. The stereochemical requirements for DNA intercalation are discussed. The relationship between the DNA affinity and bioactivity is also pointed out.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D001665:Binding Sites; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D009279:Naphthacenes / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013950:Thymus Gland / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D004247:DNA