[Pharmacologic studies on the effect of 3-carbethoxyamino-5-dimethylamino-acetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS 015) on the vegetative and central nervous system].
The substance GS 015 was tested as to its influence on the vegetative and the central nervous system. The total of side effects is low. In spite of the structural resemblance the aspect of action does not correspond to that of tricyclic psychopharmaceutical agents. Pharmacologically relevant doses bring about: local anaesthesia, musculotropic spasmolysis, inhibition of the serotonin-induced oedema, antiulcerative effect, intensification of the toxicity of amphetamine. The results do not oppose to a clinical use.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000927:Anticonvulsants; D001341:Autonomic Nervous System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology*; D005731:Ganglionic Stimulants; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009043:Motor Activity / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D012702:Serotonin Antagonists; D013239:Stereotyped Behavior / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D003984:Dibenzazepines; D005731:Ganglionic Stimulants; D012702:Serotonin Antagonists; C048166:tiracizine
Pharmakologische Untersuchungen zur Wirkung von 3-Carbethoxyamino-5-dimethylamino-acetyl-iminodibenzyl-hydrochlorid (Bonnecor, AWD 19-166, GS 015) auf das vegetative und zentrale Nervensystem.