Osteoarthritis of the temporomandibular joint: a light microscopic and scanning electron microscopic study of the articular cartilage of the mandibular condyle.
The aim of this study was to investigate the organization of collagen fibrils and the histopathologic alterations as well as the morphologic aspects of osteoarthritic articular cartilage of the human mandibular condyle. Nine osteoarthritic condyles, three obtained at necropsy and the other six during surgery, were examined by light microscopy and scanning electron microscopy. Light microscopic observations revealed features of progressive and regressive remodeling and the presence of clefts. Scanning electron microscopic observations showed the presence of thick, coiled fibrils at the joint surface and numerous osmiophilic lipid globules scattered between the collagen fibrils. The collagen fibrils were disordered. It was concluded that collagen fiber network disintegration and fatty degeneration comprise the osteoarthritic changes of the articular cartilage of the human mandibular condyle.
D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure; D003094:Collagen; D003238:Connective Tissue / Q000648:ultrastructure; D006801:Humans; D008055:Lipids; D008335:Mandibular Condyle / Q000473:pathology* / Q000648:ultrastructure; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D010003:Osteoarthritis / Q000473:pathology*; D013705:Temporomandibular Joint Disorders / Q000473:pathology*
D008055:Lipids; D003094:Collagen