Blast crisis of chronic granulocytic leukemia with mast cell and basophilic precursors.
The authors report a patient with Ph1-positive chronic granulocytic leukemia (CGL) who developed "blast crisis" after six years of chronic phase. The presence of mast cell precursors and basophil blasts was demonstrated by ultrastructural morphology and cytochemistry. Membrane phenotype studies with monoclonal antibodies helped in the further characterization of these cells. The possible implication of these findings in the origin of mast cells and the relationship of these cells with basophils are discussed.
D000328:Adult; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001491:Basophils / Q000473:pathology* / Q000648:ultrastructure; D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure; D006410:Hematopoiesis; D006651:Histocytochemistry; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000097:blood* / Q000473:pathology; D008297:Male; D008407:Mast Cells / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D010544:Peroxidases; D010641:Phenotype; D014178:Translocation, Genetic
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D010544:Peroxidases