Metabolic and toxicologic study of an artificial sweetener, oxime V.
Metabolic disposition and subchronic oral toxicologic studies were conducted on a new synthetic sweetener, Oxime V. Based on radioactivity assay, the compound was readily absorbed and metabolized. Excretion was nearly quantitative 48 hours after dosing the rat, dog, and rhesus monkey. The major metabolites were formed by oxidation and reduction of the cyclohexadiene ring, oxidation of the aldoxime and dimethyl ether moieties followed by conjugation with glycine, thiomethylation of the ring, and O-glucuronidation of the aldoxime. A two-month feeding study was conducted with male adult rats. The average consumption of Oxime V was 396.5 mg/kg per day by rats fed a diet containing 0.6% of the test compound. No treatment related histopathologic lesion was observed in the liver, kidney, spleen, and testes. The liver weight relative to the body weight and serum bilirubin level were increased.
D000818:Animals; D001711:Biotransformation; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D003510:Cyclohexanes / Q000378:metabolism / Q000633:toxicity*; D053138:Cyclohexenes; D004285:Dogs; D008099:Liver / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D013058:Mass Spectrometry; D008745:Methylation; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013549:Sweetening Agents / Q000378:metabolism / Q000633:toxicity*
D003510:Cyclohexanes; D053138:Cyclohexenes; D013549:Sweetening Agents; C047389:oxime V