[Comparative characteristics of protein-synthesizing apparatus of diploid and aneuploid human embryo fibroblasts].
The time of average polypeptide chain synthesis (tc), distribution of synthesized polypeptides according to their molecular masses, the ratio of translating and nontranslating ribosomes and polyribosomes of different size have been analyzed for diploid and aneuploid strains of fibroblasts. The magnitude of tc as well as the size of polypeptide chains synthesized were found to be similar for both kinds of fibroblasts. The relative cellular content of the translating ribosomes has been shown to decrease during the transition of cells from both strains to the stationary growth phase. The relative content of heavy polyribosomes is lower in aneuploid cells as compared with that in diploid cells. The process of translation in aneuploid fibroblasts is concluded to have no essential deviations from normal.
D000782:Aneuploidy; D002478:Cells, Cultured; D004171:Diploidy; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D010452:Peptide Biosynthesis; D011132:Polyribosomes / Q000032:analysis; D014176:Protein Biosynthesis
Sravnitel'naia kharakteristika beloksinteziruiushchego apparata diploidnykh i aneuploidnykh fibroblastov émbrionov cheloveka.