Chromosomal locations of human tissue plasminogen activator and urokinase genes.
A panel of human-mouse somatic cell hybrids and specific complementary DNA probes were used to map the human tissue plasminogen activator and urokinase genes to human chromosomes 8 and 10, respectively. This result is in contrast to a previous assignment of a plasminogen activator gene to chromosome 6. As neoplastic cells produce high levels of plasminogen activator, it is of interest that aberrations of chromosome 8 have been linked to various leukemias and lymphomas and that two human oncogenes, c-mos and c-myc, have also been mapped to chromosome 8.
D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D007938:Leukemia / Q000235:genetics; D008223:Lymphoma / Q000235:genetics; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010960:Plasminogen Activators / Q000235:genetics*; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics*
D004247:DNA; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator