Suppression of prostaglandin F-2 alpha release and delay of luteolysis after active immunization against oxytocin in the goat.
Active immunization against oxytocin significantly prolonged the oestrous cycle in 3 out of 4 goats; the mean (+/- s.e.m.) cycle length was 29.1 +/- 1.7 days (n = 12) compared to 19.4 +/- 0.6 days (n = 9) in control animals. During Days 10-21 of the cycle in the 3 responsive goats, peripheral plasma concentrations of progesterone and oxytocin were steady and those of 13,14-dihydro-15-keto-prostaglandin F-2 alpha were very low (50-100 pg X ml-1) with no marked pulsatile activity. The major effect of immunization would appear to be suppression of the synthesis of the uterine luteolysin PGF-2 alpha, thus confirming that endogenous oxytocin has a facilitatory role in luteolysis via prostaglandin production.
D000818:Animals; D003338:Corpus Luteum / Q000502:physiology*; D015237:Dinoprost / Q000031:analogs & derivatives; D004971:Estrus; D005260:Female; D006041:Goats; D007114:Immunization; D010121:Oxytocin / Q000032:analysis / Q000276:immunology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000037:antagonists & inhibitors* / Q000097:blood; D011863:Radioimmunoassay
D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D010121:Oxytocin; D015237:Dinoprost