Structure-activity studies on methoxy-substituted phenylisopropylamines using drug discrimination methodology.
Eighteen rats were trained to discriminate 1.0 mg/kg of (+)-amphetamine sulfate from saline in a two-lever operant procedure. Once responding was stable, these animals were administered various doses of sixteen different methoxy-substituted phenylisopropylamines in tests of stimulus generalization. Of three possible mono-methoxyphenylisopropylamines, all three produced amphetamine-appropriate responding, but none was as potent as racemic amphetamine. The amphetamine-stimulus did not completely generalize to any of the di- or tri-methoxyphenylisopropylamines.
D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003216:Conditioning, Operant; D004193:Discrimination Learning; D004353:Drug Evaluation, Preclinical; D005795:Generalization, Stimulus; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D000662:Amphetamines; D011619:Psychotropic Drugs; D000661:Amphetamine; C100230:4-methoxyamphetamine