[Change in the activity of tumor cell antigens as affected by treatment of the cells with the metabolic products of Bac. mesentericus AB-56].
Tumour cells (ascitic A/Sn mouse lymphosarcoma ON-2), treated by the Bac. mesentericus AB-56 metabolism products used for the production of antitumour autovaccines were analyzed for their antigenic properties. The reactions of precipitation in gel, zonal and oncoming immunoelectrophoresis, passive hemagglutination as well as cytotoxic, absorption and transplantation tests were used. A considerable number of soluble and insoluble antigens inherent in intact tumour cells were inactivated by the products of microbial metabolism in the process of antitumour vaccine production, and modified antigens which induce synthesis of humoral antibodies in the syngenic system appeared.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D001407:Bacillus / Q000378:metabolism*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology; D051379:Mice; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control; D014612:Vaccines
D000951:Antigens, Neoplasm; D014612:Vaccines
Izmenenie aktivnosti antigenov kletok opukholeĭ pri obrabotke ikh produktami metabolizma Bac. mesentericus AB-56.