Inhibition of Friend cell erythrodifferentiation by modification of membrane phospholipid composition by choline analogues.
Dimethylsulfoxide-stimulated Friend leukemia cell erythrodifferentiation was inhibited by choline analogues such as N-monomethylethanolamine and N,N-dimethylethanolamine. Phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine were then accumulated in the cell membranes. N-Monomethylethanolamine also inhibited Friend leukemia cell erythrodifferentiation stimulated by hexamethylene bisacetamide and N-methylacetamide, but did not inhibit differentiation induced by sodium butyrate. This inhibitory effect of N-monomethylethanolamine was partially abrogated by spermine.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002794:Choline / Q000031:analogs & derivatives*; D003642:Deanol / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004983:Ethanolamines / Q000494:pharmacology; D005622:Friend murine leukemia virus; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology*; D010714:Phosphatidylethanolamines / Q000097:blood; D010743:Phospholipids / Q000097:blood*
D004983:Ethanolamines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; C032000:phosphatidyl-N-monomethylaminoethanol; C026508:phosphatidyldimethylethanolamine; D003642:Deanol; D002794:Choline; D004121:Dimethyl Sulfoxide; C017500:N-methylaminoethanol