[Preliminary study in female rats of the immunoregulatory effect of estradiol, progesterone and pituitary prolactin on natural killer-like cell mediated cytotoxic activity].
A spontaneous non-immune natural killing-like cytotoxic activity is induced in cyclic non mated virgin F/344 females by progesterone + oestradiol or progesterone alone treatment after bilateral ovariectomy. Many indications attribute this cytotoxic response to the absence of the mating stimulated pituitary prolactin release which normally rescues the corpora lutea from regression, and brings about the necessary progesterone for pregnancy or pseudopregnancy.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects*; D010052:Ovariectomy; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D011920:Rats, Inbred WF
D001971:Bromocriptine; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin
Etude préliminaire chez la ratte de l'effet immuno-modulateur de l'oestradiol, de la progestérone et de la prolactine hypophysaire sur l'activité cytotoxique à médiation cellulaire "natural killing-like".