Tricyclic antidepressants antagonize prostaglandin (PG) E2-induced contractions of the guinea pig ileum and hypomotility in the mouse.
The interactions of PGE2 and 2 tricyclic antidepressants were tested both on the guinea pig ileum and motility in the mouse. PGE2-induced contractions of the guinea pig ileum were irreversibly blocked by amitriptyline and desipramine. Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D003891:Desipramine / Q000494:pharmacology*; D015232:Dinoprostone; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D007082:Ileum / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*
D006633:Histamine Antagonists; D011458:Prostaglandins E; D000639:Amitriptyline; D015232:Dinoprostone; D000109:Acetylcholine; D003891:Desipramine