[Study of the effect of parotitis vaccine on DNA repair in human lymphocytes].
The effect of parotitis vaccine virus (strain L-3) on the DNA repair synthesis induced by 4-nitroquinoline-1-oxide has been studied. The efficiency of the repair synthesis depends on individual properties of the human body, viral multiplicity and concentration of the mutagen. A two-fold increase in DNA repair synthesis was obtained after infection of cells with low viral multiplicity (0.001 HADU50 per cell) and using 2.5 x 10(-7) M concentration of the mutagen A ten-fold increase in mutagen concentration affecting the infected cells was accompanied by the inhibition of DNA repair synthesis. Lymphocytes from children studied 7 days after vaccination by the attenuated virus did not reveal any changes in DNA repair synthesis as compared with the cells from nonvaccinated children.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004260:DNA Repair; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism* / Q000648:ultrastructure; D009108:Mumps Vaccine / Q000494:pharmacology*; D009153:Mutagens
D009108:Mumps Vaccine; D009153:Mutagens
Izuchenie vliianiia parotitnoĭ vaktsiny na reparativnyĭ sintez DNK vlimfotsitakh cheloveka.