Synthesis and biological properties of 16(S)-amino-PGF2 alpha methyl ester.
A synthesis of 16-amino-derivatives of PGF2 alpha is reported. Introduction of an amino group into position 16 of PGF2 alpha has decreased the sensitivity of the compound to metabolic degradation. 16(S)-amino-PGF2 alpha methyl ester shows high abortifacient activity with reduced diarrhoeic side effect.
D000019:Abortifacient Agents / Q000138:chemical synthesis*; D000020:Abortifacient Agents, Nonsteroidal / Q000138:chemical synthesis*; D000818:Animals; D006224:Cricetinae; D003967:Diarrhea / Q000139:chemically induced; D015237:Dinoprost / Q000031:analogs & derivatives; D005260:Female; D051379:Mice; D011247:Pregnancy; D011460:Prostaglandins F / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; C045005:16-aminoprostaglandin F2alpha methyl ester; D015237:Dinoprost