Transformation of myeloma into Ph1-negative CML with plasma cell antigens.
We report a patient in whom Ph1-negative chronic myelogenous leukemia (CML) developed 15 years after the diagnosis of myeloma. Combined staining of morphologically myeloid elements in the peripheral blood for myeloid and plasmacytoid antigens revealed double-marker expression, suggesting that the two neoplasms arose from a common originator cell.
D000911:Antibodies, Monoclonal; D000941:Antigens / Q000276:immunology; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010950:Plasma Cells / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens