Perfusion of vasopressin within the rat brain suppresses prostaglandin E-hyperthermia.
These experiments were undertaken to determine whether arginine vasopressin (AVP) could suppress a prostaglandin hyperthermia and to localize sites of these actions in the rat. Prostaglandin E2 (PGE2) sensitive sites were localized in the ventral-septal area by microinjecting 200 ng/0.5 microliter of prostaglandin E2. During perfusion with an artificial CSF, PGE2 injected into the lateral cerebral ventricle evoked a hyperthermia of more than 1 degree C. Perfusion of 6.5 micrograms/ml of AVP markedly attenuated the PGE2-induced hyperthermia. These results suggest that AVP suppresses PGE2-induced hyperthermia in sites in which PGE2 evokes an increase in core temperature.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology* / Q000502:physiology; D015232:Dinoprostone; D005334:Fever / Q000503:physiopathology; D006979:Hyperthermia, Induced; D008297:Male; D011453:Prostaglandins / Q000502:physiology; D011458:Prostaglandins E / Q000037:antagonists & inhibitors*; D051381:Rats; D012688:Septum Pellucidum / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D001127:Arginine Vasopressin; D015232:Dinoprostone