Increased growth and collagen synthesis of bone marrow fibroblasts from patients with chronic myelocytic leukaemia.
Growth and collagen synthesis were measured in human bone marrow fibroblasts derived from patients with chronic myelocytic leukaemia (CML) and normal individuals. The 3H-thymidine uptake, growth rate and collagen synthesis of fibroblasts from patients with CML were significantly greater than those from normal subjects. Thus, there is increased proliferation and collagen synthesis of fibroblasts in patients with CML. These findings show that CML fibroblasts may display a greater sensitivity to stimulator contained in the fetal calf serum used for the cultures, and they are relevant to the myelofibrosis by bone marrow fibroblasts in this disease.
D000328:Adult; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism / Q000473:pathology*; D008297:Male; D013936:Thymidine / Q000378:metabolism
D003094:Collagen; D013936:Thymidine