Origin and turnover of mitochondrial glutathione.
Mitochondrial glutathione in liver does not arise by intramitochondrial synthesis, but rather from the cytoplasm, by a process characterized by slow net transport and more rapid exchange transport.
D000818:Animals; D019328:Buthionine Sulfoximine; D003553:Cystine / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013462:Sulfur Radioisotopes
D005971:Glutamates; D013462:Sulfur Radioisotopes; D008717:Methionine Sulfoximine; D003553:Cystine; D019328:Buthionine Sulfoximine; C046070:hexathionine sulfoximine; D005978:Glutathione