[Changes in the immune status indices of patients with diffuse toxic goiter in different stages of the disease].
The purpose was to study some indices of immunity in the period of mercazolyl therapy and during DTG remission. T4, T3, TSH and some indices of the immunological status: RFCc, RFCl, RFCn, stimulation index (SI) in the lymphocyte blast transformation reaction, serum immunoglobulins (Ig A, M, G) were studied in 44 patients. In diffuse toxic goiter (DTG) RFCc, RFCl and RFCn were two times and more as less, the Ig G level was raised 1.5-fold. Mercazolyl therapy corrected RFCc, RFCn whereas RFCl remained lowered. The Ig G level correlated with the T4 and T3 levels. In the DTG patients an initial drop of SI (50%) was undetectable. Mercazolyl therapy raised SI by the 4-5th week of treatment (113%). SI returned to normal by the 10-12th week. In DTG remission most of the immunologic indices returned to normal.
D000328:Adult; D002908:Chronic Disease; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006111:Graves Disease / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D012397:Rosette Formation; D013963:Thyroid Hormones / Q000097:blood
D007136:Immunoglobulins; D013963:Thyroid Hormones; D003208:Concanavalin A; D008713:Methimazole
Izmenenie pokazateleĭ immunnogo statusa bol'nykh diffuznym toksicheskim zobom na raznykh stadiiakh zabolevaniia.