Determination of cefatrizine levels in blood, tonsils, paranasal sinuses and middle ear.
Levels of cefatrizine, a new oral cephalosporin, were determined in blood and in tonsils, paranasal sinus secretions and middle ear exudates from 18 patients with acute infections at these sites. Three and six hours after administration of 500 mg cefatrizine satisfactory levels of the antibiotic were found at all the sites examined. Levels in the tonsils and middle ear were higher than those in blood, while lower levels were recorded in nasal secretions.
D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism; D002436:Cefatrizine / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D002511:Cephalosporins / Q000378:metabolism*; D004432:Ear, Middle / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D014066:Palatine Tonsil / Q000378:metabolism*; D010256:Paranasal Sinuses / Q000378:metabolism*
D002511:Cephalosporins; D002436:Cefatrizine