Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.
A 0.9kb cDNA fragment, corresponding to a large part of Rhesus monkey pepsinogen A mRNA, was used as probe for the chromosomal localization of the human pepsinogen A gene(s) using human-rodent somatic cell hybrids. Southern blot analysis of 14 human-Chinese hamster and three human-mouse cell hybrids, strongly indicates that the human PGA locus is on chromosome 11. The human-mouse hybrids, containing a translocation involving chromosome 11, allow sublocalization to the region q12-pter.
D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology; D008253:Macaca mulatta / Q000235:genetics; D051379:Mice; D010435:Pepsinogens / Q000235:genetics*
D010435:Pepsinogens; D004247:DNA