Rubidium uptake of mononuclear leukocytes from normotensive and borderline hypertensive first degree relatives to patients with essential hypertension.
Uptake of 86Rubidium of mononuclear leukocytes (MNL) was used as a measure of cellular sodium-potassium pump activity. 86Rb-uptake was determined with the pump stimulated mainly from inside the cells by sodium as well as with a combined stimulation from inside by sodium and from outside by Rb. In the first case there was an increased pump activity in MNL from borderline hypertensive offspring of hypertensive patients (BHO), and this may be related to an increased number of pump sites observed previously (10). Estimation of maximal pump activity (Vmax) of MNL suggested that Vmax of each pump site in MNL from BHO may be decreased compared to control value of MNL from healthy normotensive subjects.
D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D007962:Leukocytes / Q000378:metabolism*; D011188:Potassium / Q000097:blood; D011868:Radioisotopes; D012413:Rubidium / Q000097:blood*; D012964:Sodium / Q000097:blood
D011868:Radioisotopes; D012964:Sodium; D012413:Rubidium; D011188:Potassium