High dose epidural morphine for surgical analgesia.
A group of 30 patients undergoing various operative procedures were anesthetized using high dose epidural morphine 20 mg in 15 ml of normal saline, thiopentone induction, endotracheal intubation and muscle relaxation with pancuronium 0.1 mg/kg and controlled ventilation with oxygen and nitrous oxide. Operative conditions and patient acceptance of the technique were satisfactory. There was cardiovascular stability and prolonged postoperative analgesia. Pruritus was observed in three patients and urinary retention in one and were adequately treated. Early mild respiratory depression occurred in one patient and this was treated with naloxone. High dose epidural morphine is efficacious and safe in providing intraoperative and postoperative analgesia.
D000328:Adult; D000368:Aged; D000698:Analgesia / Q000379:methods*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007278:Injections, Spinal / Q000009:adverse effects; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000517:prevention & control*
D009020:Morphine