[Are there genetic risk factors in the occurrence of choriocarcinoma?].
Now that we know about the genetic production mechanisms of diseases of the trophoblast, interest is concentrated on the question which risk factors can produce a disposition in the patient - seen from a clinico-genetic angle - towards malignancy of a complete mole. Many years before the genetic interrelations became known, there had been discussions on blood relationship as a possible aetiological factor in the production of chorionic carcinoma. Since consanguinity in preceding generations can lead to a selection of certain genotypes, this question was reexamined on a limited patients material (10 patients with chorionic carcinoma and 11 with mole). The negative result of this study contradicts - similar to other recent publications on this subject - the hitherto frequently advanced hypothesis that homozygotism is responsible, for a recessive "onko" gen, for rendering a complete mole malignant. Recent investigations, for example, point to a close correlation between the presence of a Y chromosome in a complete mole, and malignancy.
D002822:Choriocarcinoma / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation; D005808:Genes, Recessive; D005838:Genotype; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D012306:Risk; D014424:Turner Syndrome / Q000235:genetics; D014594:Uterine Neoplasms / Q000235:genetics*; D014998:Y Chromosome
Gibt es genetische Risikofaktoren für das Auftreten eines Chorionkarzinoms?