[Beta-HCG-producing choriocarcinoma of the pineal area as a cause of precocious puberty].
We report the case of an eight-year-old boy with precocious puberty due to a beta-HCG producing choriocarcinoma of the pineal region. beta-HCG-levels were elevated initially (9659 mU/ml) and did not normalize completely after surgical removal of the brain tumor. A relapse of the tumor in the hypothalamic region led to a new increase of beta-HCG-level up to 41258 mU/ml. Histopathology of a subsequently removed metastasis in the right lung showed immunohistological evidence of beta-HCG production. Introduction of chemotherapy was followed by a normalization of the beta-HCG-level and of the previously elevated hormone values.
D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D002648:Child; D002822:Choriocarcinoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008297:Male; D010870:Pineal Gland; D011629:Puberty, Precocious / Q000209:etiology*; D014057:Tomography, X-Ray Computed
D006063:Chorionic Gonadotropin
Beta-HCG-produzierendes Choriokarzinom der Pinealisregion als Ursache einer Pubertas praecox.