Normal sister chromatid exchange frequencies during growth of a transplantable murine myeloid leukemia.
Frequencies of sister chromatid exchange (SCE) were analyzed in normal and coexisting leukemic cells harvested from the bone marrow of mice 10, 15, 18, and 21 days after transplantation of myeloid leukemic cells. These posttransplantation stages correspond to no abnormal physical or clinical symptoms (day 10) through the terminal stage of leukemia (day 21). The data indicate that the SCE frequencies in normal cells of leukemic mice did not differ from those in normal cells of normal mice. Furthermore, the frequencies in the coexisting normal and leukemic cells remained statistically constant throughout the posttransplantation period. It is concluded from this study that spontaneous cellular SCE frequencies may not be altered by the presence or growth of leukemic cells.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002453:Cell Cycle; D002455:Cell Division; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D008677:Metaphase; D051379:Mice; D012854:Sister Chromatid Exchange