Comparison of therapeutic usefulness of vitamin D3 analogs on osteoporosis caused by ovariectomy in rats.
Ovariectomy induced a remarkable reduction in the ash content of the femur and histologically a disappearance of the trabecular bone in tibial metaphysis accompanying the decrease of serum calcium level and urinary calcium excretion in young immature rats. Treatment with 1 alpha-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 1,24R-dihydroxyvitamin D3 for 3 months from 7 to 9 months after the ovariectomy dose-dependently increased serum and urinary calcium, bone ash, and histologically partly improved a loss of trabeculae. The 24R,25-dihydroxyvitamin D3 doses, on the other hand, produced no therapeutic effect on the bone disorders in ovariectomized rats, except for the slight effect on the increasing activity of serum calcium.
D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000032:analysis; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000032:analysis; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D005260:Female; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D010052:Ovariectomy / Q000009:adverse effects; D010758:Phosphorus / Q000652:urine; D051381:Rats
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D010758:Phosphorus; C023850:1 alpha,24-dihydroxyvitamin D3; D002117:Calcitriol; D002118:Calcium; C008088:alfacalcidol