Structure and variation of the influenza C glycoprotein.
The amino acid sequence of the influenza C/JHB/1/66 glycoprotein was predicted from sequence analysis of cloned DNA. The glycoprotein exhibited several similarities to the haemagglutinin (HA) glycoproteins of influenza A and B viruses, although its overall homology to these glycoproteins was low. A comparison between the sequences of C/JHB/1/66 and C/Cal/78 strains revealed 96% homology. The nucleotide and amino acid changes appeared to be non-random, with a high proportion occurring between amino acid positions 182-212. A comparison between the JHB/1/66 glycoprotein and the influenza A/X31 HA sequence suggested that this region may be structurally analogous to the 'A' antigenic site of the HA glycoprotein.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003545:Cysteine; D004247:DNA / Q000235:genetics; D005814:Genes, Viral; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics*; D006389:Hemagglutinins, Viral / Q000235:genetics; D009982:Gammainfluenzavirus / Q000235:genetics*; D009975:Orthomyxoviridae / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D004247:DNA; D003545:Cysteine