Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice.
The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D004744:Enkephalin, Methionine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D010622:Phencyclidine / Q000494:pharmacology*; D010648:Phenylacetates / Q000378:metabolism*
D010648:Phenylacetates; D015102:3,4-Dihydroxyphenylacetic Acid; D004744:Enkephalin, Methionine; D009020:Morphine; D010622:Phencyclidine; D004298:Dopamine; D006719:Homovanillic Acid