Differences in regional brain concentrations of neuropeptide Y in spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats.
Regional brain concentrations of neuropeptide Y immunoreactivity (NPY) were measured in age-matched Wistar-Kyoto (WKY) and spontaneously hypertensive (SH) rats using a sensitive and specific radioimmunoassay developed within our laboratory. In 5 of the 9 brain regions examined the SH rats had significantly lower NPY levels compared to the WKY strain. The largest differences occurred within the cortex (-43%), and cervical (-30%) and thoracic spinal cord (-30%), whilst smaller differences were observed in the midbrain (-11%) and medulla oblongata-pons (-18%). The concentrations of NPY in the hypothalamus and hippocampus did not vary between the strains. The SH rats contained significantly greater (+18%) NPY levels in the striatum compared to the WKY rats.
D000818:Animals; D002490:Central Nervous System / Q000032:analysis*; D005260:Female; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009478:Neuropeptide Y; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013045:Species Specificity
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y