Endocrinological effects of intrathecal morphine.
This study was designed to evaluate the metabolic effects of intrathecal morphine in patients undergoing coronary artery surgery. Ten patients received 4 mg preservative-free morphine in 6 ml saline intrathecally before surgery and were compared with 10 patients anaesthetised in a similar manner, though without intrathecal morphine. Catecholamines, cortisol and glucose measurements were made during surgery and for 24 h post-operatively. The control group had a higher post-operative requirement for papaveretum, indicating that intrathecal morphine provided some post-operative analgesia. In the period from end of surgery to 5 h after surgery, cortisol secretion was suppressed in the intrathecal morphine group.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002395:Catecholamines / Q000097:blood*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D014132:Trachea
D001786:Blood Glucose; D002395:Catecholamines; D009020:Morphine; D005283:Fentanyl; D006854:Hydrocortisone