Effect of polybrene on isolation of Chlamydia trachomatis from clinical specimens.
Polybrene treatment of McCoy cells was used to increase the infectivity of Chlamydia trachomatis in vitro. The isolation rate for C. trachomatis in 500 specimens from males and females attending a sexually transmitted disease clinic and other clinics increased by 6.8% with the Polybrene treatment. The data also suggested that this treatment facilitated the diagnosis of low grade or latent infections.
D000293:Adolescent; D000328:Adult; D002460:Cell Line; D002584:Cervix Uteri / Q000382:microbiology*; D002690:Chlamydia Infections / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000302:isolation & purification*; D005260:Female; D006583:Hexadimethrine Bromide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011073:Polyamines / Q000494:pharmacology*; D012749:Sexually Transmitted Diseases / Q000382:microbiology; D014521:Urethra / Q000382:microbiology*
D011073:Polyamines; D006583:Hexadimethrine Bromide