A special lipid mixture for membrane fluidization.
The potency for membrane fluidization of mixtures containing neutral lipids (NL), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) from hen egg yolk was tested on human erythrocytes and lymphocytes. A specific mixture consisting of 70% NL, 20% PC and 10% PE was found to be a potent membrane fluidizer operating almost exclusively by extracting membrane cholesterol. Spectral results and electron micrographs indicate that aqueous dispersion of this mixture consists of chylomicron-like assemblies where the neutral lipids provide the hydrophobic core on the surface of which phospholipids are spread as a monolayer.
D004338:Drug Combinations / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D005989:Glycerides / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects*; D008854:Microscopy, Electron; D010713:Phosphatidylcholines / Q000494:pharmacology; D010714:Phosphatidylethanolamines / Q000494:pharmacology; D013053:Spectrophotometry
D004338:Drug Combinations; D005989:Glycerides; D008055:Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; C046637:neutral lipid, phosphatidylcholine, phosphatidylethanolamine drug combination