Osteonecrosis of sternum and rib in a patient treated for Hodgkin's disease.
A 39-year-old man is described in whom osteonecrosis of the manubrium sterni developed 23 months and of a rib 25 months after treatment for Hodgkin's disease Stage IIIB with polychemotherapy and subdiaphragmatic radiotherapy. The radiologic and histologic characteristics of this very rare localization of steroid-associated osteonecrosis are discussed.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage / Q000009:adverse effects; D010020:Osteonecrosis / Q000139:chemically induced* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D011344:Procarbazine / Q000008:administration & dosage / Q000009:adverse effects; D012272:Ribs / Q000473:pathology*; D013249:Sternum / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone