Inactivation of guinea-pig serum proteinase inhibitors by Bacteroides gingivalis.
The activity of proteinase inhibitors of guinea-pig serum was evaluated by using trypsin as test enzyme. Strains of black-pigmented Bacteroides species were incubated with serum under anaerobic conditions. Strains of Bacteroides gingivalis inactivated the trypsin inhibitors of guinea-pig serum within 1 h, while the other strains reduced the activity of the trypsin inhibitors by less than 50% within 48 h. The inactivation of proteinase inhibitors of guinea-pig serum by B. gingivalis may be an important pathogenic mechanism in the spreading necrotic infections induced in guinea pigs by pure cultures of this species.
D000818:Animals; D001439:Bacteroides / Q000502:physiology*; D001770:Blood Bactericidal Activity; D004789:Enzyme Activation; D005881:Gingiva / Q000382:microbiology; D006168:Guinea Pigs; D013997:Time Factors; D014361:Trypsin Inhibitors / Q000037:antagonists & inhibitors* / Q000097:blood
D014361:Trypsin Inhibitors