Long arm deletion of chromosome 5 in a case of chronic myelomonocytic leukemia.
The 46,XY,del(5)(q31),del(12)(p11) and 46,X,-Y,del(5)(q31),del(12)(p11), +mar clones were found in the bone marrow cells of a 64-year-old Japanese man with chronic myelomonocytic leukemia (CMML). Although the 5q- anomaly has been reported to occur in various hematologic disorders, a literature survey of CMML cases revealed that the present case is the first instance of CMML with the 5q- anomaly. The possible significance of the chromosome findings is discussed.
D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000473:pathology; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged