Comparative efficacy of injection routes and doses of ivermectin against Psoroptes in rabbits.
Rabbits infested with Psoroptes ovis (Hering) or with P cuniculi (Delafond) were injected IM or subcutaneously with ivermectin or with vehicle. A single injection of ivermectin (200 micrograms/kg) either IM or subcutaneously was inadequate to eliminate all mites in the ears of the rabbits. However, a single injection of ivermectin at 400 micrograms/kg, regardless of the route of injection, eliminated all P cuniculi mites, but eliminated P ovis mites in only 50% of the rabbits. Ivermectin was more effective against P cuniculi than against P ovis at both doses tested, regardless of the route of injection.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage*; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage*; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D008925:Mites; D011817:Rabbits; D013045:Species Specificity
D007306:Insecticides; D007783:Lactones; D007559:Ivermectin