Brain calcification in Kallman's syndrome. Computed tomographic appearance.
We report a 21-year-old white male with Kallman's syndrome (gonadotropic hypogonadism, hyposmia and sensorineural hearing loss) with extensive brain calcification, demonstrated for the first time by computed tomography. The pattern and anatomic distribution of the extensive brain calcification is nonspecific, being indistinguishable from those seen in other causes of brain calcification (principally diseases related to a disturbance in calcium metabolism), despite the normal serum calcium levels found in this patient. This syndrome, therefore, should be considered along with Cockayne's, Kearns-Sayre and Down's syndromes, tuberous sclerosis, carbonic anhydrase II deficiency, congenital mental deficiency and idiopathic familial basal ganglia calcification as another developmental cause of brain calcification, which usually show no disturbance in serum calcium level.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging*; D006319:Hearing Loss, Sensorineural / Q000150:complications; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D008297:Male; D000857:Olfaction Disorders / Q000150:complications; D013577:Syndrome; D014057:Tomography, X-Ray Computed