[State of the blood prekallikrein-kallikrein system in patients with glomerulonephritis as affected by pathogenetic therapy].
A study was made of the effect of the treatment with glucocorticoids (GC), cyclophosphamide and indocide on the prekallikrein-kallikrein system (PKKS) of the blood in 108 patients with glomerulonephritis. It was revealed that in patients with acute and chronic GN, the PKKS was activated before treatment. The PKKS activation was marked by a decrease in the content of prekallikrein and elevation of the alpha 2-macroglobulin content, particularly in patients with the nephrotic syndrome. The efficacy of GC therapy was more pronounced the higher the basic activation of the PKKS. The clinical effect of indocide and cyclophosphamide did not depend on the initial characteristics of the PKKS.
D000208:Acute Disease; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005921:Glomerulonephritis / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007610:Kallikreins / Q000032:analysis*; D011288:Prekallikrein / Q000032:analysis*
D005938:Glucocorticoids; D003520:Cyclophosphamide; D011288:Prekallikrein; D007610:Kallikreins; D007213:Indomethacin
Sostoianie prekallikrein-kallikreinovoĭ sistemy krovi u bol'nykh glomerulonefritom pod vliianiem patogeneticheskoĭ terapii.