2-Substituted-3-pyridinolethers as hypolipidemic and platelet aggregation inhibiting agents.
Some 2-substituted 3-pyridinolethers were synthesized, with one side chain bearing a carboxylic function; among these there are products having structure analogies with the prostaglandins. The results of hypolipidemic and hypocholesterolemic tests on experimental hyperdyslipidemic animals, as well as those on the inhibition of platelets aggregation and on fibrinolytic activity are reported.
D000818:Animals; D000924:Anticholesteremic Agents / Q000037:antagonists & inhibitors; D055598:Chemical Phenomena; D002621:Chemistry; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D008383:Margarine / Q000008:administration & dosage; D051379:Mice; D009821:Oils / Q000008:administration & dosage; D000069463:Olive Oil; D010938:Plant Oils; D010974:Platelet Aggregation / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D009821:Oils; D000069463:Olive Oil; D010938:Plant Oils; D011725:Pyridines; D014280:Triglycerides; D000431:Ethanol; D011092:Polyethylene Glycols; D008383:Margarine