The urinary excretion of ionized and non-ionized calcium by rats treated with 1.25-dihydroxycholecalciferol.
The administration of 1,25-dihydroxycholecalciferol to rats increased their calciuresis as a power function of the dose. Up to 95% of the urinary calcium was excreted as a non-ionized complex, together with equimolar amounts of citrate. The stoichiometry between calcium and citrate, observed at all dose levels, suggests that citrate metabolism is coordinated with the mobilization of calcium.
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000652:urine*; D002951:Citrates / Q000097:blood; D019343:Citric Acid; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D007668:Kidney / Q000032:analysis / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002951:Citrates; D019343:Citric Acid; D003404:Creatinine; D002117:Calcitriol; D002118:Calcium