[Lectin-inducible cell cytotoxicity and the production of the cytotoxic factor of natural killer cells during immobilization stress in mice].
Mice exposed to immobilization stress manifested a dramatic lowering of the activity of normal killers against YAC-1 tumor as well as against the lectin-induced cellular cytotoxicity mediated by Helix pomatia agglutinin and detected by the cytolytic test against xenogeneic tumor cells K 562. Exposure to stress did not provoke any change in the production of cytotoxic factor of normal killers, whereas dexamethasone (5 X 10(-7) M) in vitro inhibited the production of this factor.
D000373:Agglutinins / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology; D006372:Helix, Snails; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D055646:Killer Factors, Yeast; D037102:Lectins / Q000494:pharmacology*; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D014176:Protein Biosynthesis; D011506:Proteins / Q000276:immunology; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology*
D000373:Agglutinins; D055646:Killer Factors, Yeast; D037102:Lectins; D008222:Lymphokines; D011506:Proteins; D003907:Dexamethasone
Indutsiruemaia lektinom kletochnaia tsitotoksichnost' i produktsiia tsitotoksicheskogo faktora normal'nykh killernykh kletok pri immobilizatsionnom stresse u mysheĭ.