Aluminum-free oral phosphate binder.
For the purpose of intestinal phosphate binding we have developed aluminum free substances. These substances are natural polymers consisting of heteropolyuronic acid charged with different cations. The in vitro experiments showed an efficacy 2 to 3 times greater than Aludrox. During the clinical application, up to one year, no serious side effects have been detected. Serum phosphate levels could not be lowered in all patients to the desired level of 5 mg% mainly due to problems in patients compliance and to low dosage of the prescribed phosphate binder.
D000284:Administration, Oral; D002614:Chelating Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D010316:Particle Size; D010710:Phosphates / Q000378:metabolism*; D011108:Polymers / Q000627:therapeutic use*; D011208:Powders
D002614:Chelating Agents; D010710:Phosphates; D011108:Polymers; D011208:Powders