The inheritance of enzyme variants of glutamic-oxaloacetic transaminase in Paragonimus ohirai.
Lung flukes, Paragonimus ohirai, from Kinosaki, Japan, characterized by 3 electrophoretic variants, FF, FS and SS, of glutamic-oxaloacetic transaminase (GOT: EC 2.6.1.1) were crossed in the laboratory. In the case of a cross between FS and SS, a parent, FS, produced 9 SS and 16 FS clones in the offspring, numbers not significantly different from that expected (1:1) from Mendelian inheritance. From the other cross FS X FF, 20 clones originating from the respective 20 miracidia were obtained from a parent FS. The phenotype segregation ratio was 6 FF and 14 FS, which is not significantly different from Mendelian inheritance expectation. Only 3 clones were obtained from the other parent FF, but these segregated in a ratio of 2 FS: 1 FF. These breeding data indicate that the GOT isozymes of P. ohirai are controlled by 2 codominant alleles, GotF and GotS at a single locus whose products aggregate randomly, forming a dimer.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000235:genetics*; D003386:Brachyura / Q000469:parasitology; D004592:Electrophoresis, Starch Gel; D014644:Genetic Variation; D007527:Isoenzymes / Q000032:analysis / Q000235:genetics; D007564:Japan; D010238:Paragonimus / Q000201:enzymology / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012908:Snails / Q000469:parasitology
D007527:Isoenzymes; D001219:Aspartate Aminotransferases