Effects of prostaglandin E2 (PGE2) on estradiol-17 beta-induced luteolysis in the nonpregnant ewe.
Fifteen ewes were assigned as they came into estrus to the following randomized treatment groups: 1) Vehicle (1 ml corn oil + vehicle Na2CO3 buffer), 2) Estradiol-17 beta + vehicle and 3) Estradiol-17 beta + PGE2 (500 micrograms) in Na2CO3 buffer (5 ewes/treatment group). Prostaglandin E2 was given through an intrauterine cannula every four hours from days 8 through 15 postestrus. PGE2 prevented a luteolytic dose of estradiol-17 beta given on days 9 and 10 from causing a precocious luteolysis. PGE2 maintained concentrations of progesterone in peripheral blood (days 8 through 15) and weights and concentrations of progesterone in corpora lutea on day 15 postestrus of ewes receiving estradiol-17 beta. It is concluded that chronic intrauterine infusions of PGE2 can prevent an estradiol-17 beta-induced premature luteolysis.
D000818:Animals; D015232:Dinoprostone; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D003341:Luteolysis / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011458:Prostaglandins E / Q000494:pharmacology*; D012756:Sheep
D011458:Prostaglandins E; D011374:Progesterone; D004958:Estradiol; D015232:Dinoprostone