The primary structure of the fourth component of human complement (C4)-C-terminal peptides.
C-terminal CNBr peptides of the three polypeptide chains of C4 were obtained and sequenced. These results supplement previously obtained data, notably the protein sequence derived from cDNA sequencing of pro-C4 (Belt KT, Carroll MC & Porter RR (1984) Cell 36, 907-914) and the N-terminal sequences of the three polypeptides (Gigli I, von Zabern I & Porter RR (1977) Biochem. J. 165, 439-446), to define the complete primary structure of the plasma form of C4. The beta (656 residues), alpha (748 residues), and gamma (291 residues) chains are found in positions 1-656, 661-1408, and 1435-1725 in the pro-C4 molecule.
D000595:Amino Acid Sequence; D003181:Complement C4 / Q000235:genetics / Q000302:isolation & purification; D015935:Complement C4b; D003488:Cyanogen Bromide; D004247:DNA; D006801:Humans; D046911:Macromolecular Substances; D010446:Peptide Fragments / Q000032:analysis
D003181:Complement C4; D046911:Macromolecular Substances; D010446:Peptide Fragments; C033860:complement C4c; D015935:Complement C4b; D004247:DNA; D003488:Cyanogen Bromide