The Philadelphia (Ph) chromosome in leukemia. III. Complex Ph translocation plus inversion in chronic myelocytic leukemia.
Remarkable chromosome abnormalities were observed in bone marrow cells from a woman with chronic myelocytic leukemia and atypical tuberculosis due to Mycobacterium avium-intracellulare infection. Four chromosome breaks occurred at bands 1p13, 1q32, 11p15, and 22q11. These breaks resulted in a complex Philadelphia (Ph) translocation between chromosomes #1, #11, and #22 and in an inversion of chromosome #1. Oncogenes on these chromosomes include N-ras and c-sk on chromosome #1, c-H-ras on chromosome #11, and c-sis on chromosome #22. Complex chromosome rearrangements may facilitate multiple oncogene changes, thereby permitting several steps in cancer development to occur simultaneously.
D000328:Adult; D001853:Bone Marrow / Q000382:microbiology / Q000473:pathology; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000150:complications / Q000235:genetics*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D009162:Mycobacterium avium / Q000302:isolation & purification; D014178:Translocation, Genetic; D014376:Tuberculosis / Q000150:complications