Acute myeloblastic leukemia and sarcoidosis. Implications for pathogenesis.
A disorder characterized by anemia and neutropenia due to impaired bone marrow function and a multisystem noncaseating granulomatous (NCG) disorder typical of sarcoidosis, culminated in acute myeloblastic leukemia (AML) in a patient after 6 years of observation. Linkage between the leukemia and sarcoidosis is suggested by a precedent case report, by the statistical remoteness of a fortuitous concurrence, by numerous reported instances of regional or systemic NCG accompanying a variety of malignancies, and by evidence of AML immunogenicity. It appears possible that the sarcoidosis in this patient represented a tissue reaction to the AML.
D000328:Adult; D000740:Anemia / Q000209:etiology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000209:etiology* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology; D009503:Neutropenia / Q000209:etiology; D012507:Sarcoidosis / Q000209:etiology* / Q000473:pathology