Species dependent variability in the susceptibility of coagulase-negative staphylococci to various antimicrobial agents.
The in-vitro activity of 20 beta-lactam antibiotics and vancomycin was determined against three different species of coagulase-negative-staphylococci. All isolates were susceptible to vancomycin (MIC90 3.12-6.25 mg/l) although occasional tolerance was seen. Most isolates (85%) of Staphylococcus hominis were susceptible to methicillin and other beta-lactams including cephalothin, cefapirin, cefamandole, imipenem and BMY28142, while 90% of Staph. haemolyticus isolates were resistant to these agents. Staph. epidermidis was intermediate in susceptibility with 50% of isolates being methicillin resistant (MR). These MR isolates exhibited cross-resistance or tolerance to the other beta-lactam agents except cefamandole.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003030:Coagulase / Q000378:metabolism*; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003030:Coagulase; D008712:Methicillin