Family of human alpha-interferon-like sequences.
An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10 of which were isolated as clones. Some of these sequences were located within a few kilobases of alpha-interferon genes, consistent with our assignment of several members of the family to human chromosome 9 which also has the beta 1- and alpha-interferon genes.
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000032:analysis; D006801:Humans; D007370:Interferon Type I / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000235:genetics; D009693:Nucleic Acid Hybridization; D012334:RNA, Neoplasm / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid
D004274:DNA, Recombinant; D007370:Interferon Type I; D012334:RNA, Neoplasm