Enhanced reactivation of UV-irradiated adenovirus 2 in HeLa cells treated with non-mutagenic chemical agents.
Treatment of HeLa cells with ethanol and sodium arsenite, compounds which are known to elicit the heat-shock response, before infection with UV-irradiated adenovirus 2 has been found to result in the enhanced reactivation of the damaged virus in a manner similar to that obtained by pre-irradiation or heating of the cells. Enhanced reactivation may be the result of the inhibition of DNA synthesis caused by these agents since hydroxyurea also produced a significant enhancement.
D000260:Adenoviruses, Human / Q000235:genetics* / Q000528:radiation effects; D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D017670:Sodium Compounds; D014466:Ultraviolet Rays
D018053:Arsenites; D017670:Sodium Compounds; D000431:Ethanol; C017947:sodium arsenite; D004247:DNA; D001151:Arsenic