Absorption of minocycline hydrochloride and tetracycline hydrochloride. Effect of food, milk, and iron.
Serum concentrations of tetracycline hydrochloride and minocycline hydrochloride were compared when administered with water, milk, a meal, and 300 mg ferrous sulfate in two groups of eight volunteers. Absorption of both antibiotics was significantly decreased by administration with iron (77% inhibition with minocycline and 81% with tetracycline), milk (27% inhibition with minocycline, 65% with tetracycline), and food (13% inhibition with minocycline and 46% with tetracycline). The inhibitory effect on absorption with food and milk was significantly greater for tetracycline than for minocycline.
D000818:Animals; D003692:Delayed-Action Preparations; D005296:Ferrous Compounds / Q000494:pharmacology*; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000494:pharmacology*; D008892:Milk; D008911:Minocycline / Q000008:administration & dosage / Q000097:blood*; D013752:Tetracycline / Q000008:administration & dosage / Q000097:blood*; D013754:Tetracyclines / Q000097:blood*; D013997:Time Factors
D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; D013754:Tetracyclines; C020748:ferrous sulfate; D007501:Iron; D013752:Tetracycline; D008911:Minocycline