Novel potentiators of beta-lactam antibiotics. Isolation of SQ28,504 and SQ28,546 from Chromobacterium violaceum.
Two novel compounds, SQ28,504 and SQ28,546 are produced by Chromobacterium violaceum. These compounds enhance the antibacterial activity of beta-lactam antibiotics against Gram-negative organisms. Both SQ28,504 and SQ28,546 induce morphological changes in the presence of beta-lactam antibiotics. Only SQ28,546 has weak antimicrobial activity against several Gram-negative organisms.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002861:Chromobacterium / Q000378:metabolism*; D005285:Fermentation; D006020:Glycopeptides / Q000302:isolation & purification; D007769:Lactams; D008970:Molecular Weight; D013057:Spectrum Analysis; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; D007769:Lactams; D047090:beta-Lactams; C045689:SQ 28504; C045690:SQ 28546