Dihydromonacolin L and monacolin X, new metabolites which inhibit cholesterol biosynthesis.
Dihydromonacolin L and monacolin X those are structurally related to monacolin K, a potent inhibitor of cholesterol biosynthesis, were isolated from cultures of a mutant of Monascus ruber. The structures of these two metabolites were determined by a combination of physical techniques. Data for dihydromonacolin L and monacolin X as inhibitors of hydroxymethylglutaryl-CoA reductase and sterol biosynthesis in vitro are also given.
D000818:Animals; D000924:Anticholesteremic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000096:biosynthesis*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; C045373:dihydromonacolin L; C045374:monacolin X; D002784:Cholesterol