The histopathologic spectrum in Mycobacterium marinum infection.
Review of nine culture-positive cases of Mycobacterium marinum infection revealed a broad range in the histopathologic features of lesions produced by this organism. Four synovial lesions and five cutaneous infections were observed. A range of inflammatory changes were seen in both synovial and skin lesions, varying from mostly acute inflammation with suppuration to a more chronic process with numerous, well-formed granulomas. Organisms were observed in the biopsy sections of only one of the nine cases. Therefore, culture of the biopsy tissue at 30 degrees C is crucial in establishing the diagnosis. These cases emphasize the importance of considering mycobacterial infection and performing cultures even when granulomatous changes in the synovium or skin are subtle.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000473:pathology*; D009165:Mycobacterium Infections, Nontuberculous / Q000473:pathology*; D012874:Skin Diseases, Infectious / Q000209:etiology / Q000473:pathology*; D013585:Synovitis / Q000209:etiology / Q000473:pathology*