Computerized interactive morphometry. A study of malignant mesothelioma and mesothelial hyperplasia in pleural biopsy specimens.
A morphometric study of 11 pleural malignant mesotheliomas and 11 pleural reactive mesothelial proliferations is reported. Pleural biopsy specimens of these lesions were studied with a new system of video-based computerized interactive morphometry that allows the comparison of real-time images of nuclear profiles with computer-generated graphic standards for the purpose of estimating their diameters. Malignant mesotheliomas had nuclear profile diameters (NPDs) ranging from 4 to 14 micron and a mean NPD of 9.6 +/- 0.5 micron. Reactive mesothelial proliferations had NPDs ranging from 4 to 12 micron, but exhibited a significantly smaller mean NPD of 6.4 +/- 0.2 micron. The potential technical advantages of computerized interactive morphometry over other morphometric methods are discussed.
D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure; D006801:Humans; D006965:Hyperplasia; D008654:Mesothelioma / Q000473:pathology*; D008905:Minicomputers; D010994:Pleura / Q000473:pathology; D010997:Pleural Neoplasms / Q000473:pathology*; D012984:Software