Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa.
In chronic P. aeruginosa infection, lung tissue damage is induced by either the microorganism or the inflammatory response. We investigated, in an animal model, whether a non-steroidal anti-inflammatory drug, ibuprofen, reduced lung inflammation produced by P. aeruginosa. Lung lavages, pulmonary clearance of P. aeruginosa and lung pathology were studied in CD-1 mice injected with sodium ibuprofenate. A single dose of the drug, injected immediately after 30 min exposure to the P. aeruginosa aerosol, decreased the recruitment of granulocytes into airways in a dose-dependent manner. Pretreatment with 2 doses of the drug 18 and 6 h before the P. aeruginosa challenge was even more effective. The kinetics of changes in prostaglandin E2, 6-keto-prostaglandin F1 alpha and thromboxane B2 concentrations in lung lavage fluids after P. aeruginosa aerosol were also modified by ibuprofen. Moreover, ibuprofen treatment did not impair lung clearance of the challenge microorganisms, and the animals had less inflammation of the lungs.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D015232:Dinoprostone; D004195:Disease Models, Animal; D007052:Ibuprofen / Q000627:therapeutic use*; D007249:Inflammation; D007700:Kinetics; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000378:metabolism; D011014:Pneumonia / Q000188:drug therapy* / Q000473:pathology; D011458:Prostaglandins E / Q000378:metabolism; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000473:pathology; D007507:Therapeutic Irrigation; D013929:Thromboxane B2 / Q000378:metabolism
D011458:Prostaglandins E; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone; D007052:Ibuprofen