[Summarized presentation of studies on the toxicology of 3-carbethoxyamino-5-dimethylamino-acetyl-10,11- dihydrobenz[b,f]azepine hydrochloride (Bonnecor, GS 015, AWD 19-166)].
To ensure toxicologically the potential antiarrhythmic agent 3-carbethoxyamino-5-dimethylamino-acetyl-10,11-dihydro-dibenz[b,f] azepine hydrochloride (Bonnecor, GS 015, AWD 19-166), the following preclinical studies have been made up to the present: Determination of the acute toxicity on mice and rats, toxicity test on the rat by repeated applications, study as to the action of GS 015 on the prenatal development of the rat, diverse toxicologic studies on reproduction, mutagenity tests by using the DNA repair test and the Ames test. The results of these studies are represented in a summarized form. A good tolerance of GS 015 can be derived from the results of the preclinical studies gained up to now.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects; D003984:Dibenzazepines / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007774:Lactation / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009152:Mutagenicity Tests; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013045:Species Specificity; D013723:Teratogens; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D003984:Dibenzazepines; D013723:Teratogens; C048166:tiracizine
Zusammenfassende Darstellung der Untersuchungen zur Toxikologie von 3-Carbethoxyamino-5-dimethylamino-acetyl-10,11-dihydrodibenz- [b,f]azepin-hydrochlorid (Bonnecor, GS 015, AWD 19-166).