Effects of D-penicillamine on collagen biosynthesis by fibroblast cell cultures.
The effects of D-penicillamine on collagen and total protein synthesis by fibroblast cell cultures were studied. High concentration of D-penicillamine (10 mmol/l) produced a toxic effect consisting of inhibition of growth and a non-specific increase in protein synthesis. A low concentration of D-penicillamine (100 mumol/l) decreased the biosynthesis of both type I and type III collagens.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D010396:Penicillamine / Q000494:pharmacology*; D014176:Protein Biosynthesis; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D003094:Collagen; D010396:Penicillamine