Hexaprazol antagonism to gastric electrical potential fall by acetylsalicylic acid in rat.
Hexaprazol was tested against the gastric barrier breaking effect of aspirin (ASA), using the electric potential difference (PD) test in rats without pyloric ligation. The activity of hexaprazol was evident at a dose lower than the antisecretory one and also at the same range of antiulcer doses. The drug's activity in reducing the PD fall induced by ASA was compared with that of carbenoxolone, pirenzepine, cimetidine and ranitidine administered by the same route. Their relative activity, measured by AUB (area under baseline) index, followed this order: carbenoxolone greater than hexaprazol greater than pirenzepine greater than cimetidine greater than ranitidine. Measured by RI (irritancy index) inhibition, the order of activity was similar: carbenoxolone greater than hexaprazol greater than or equal to pirenzepine greater than cimetidine greater than ranitidine. It was demonstrated that hexaprazol had an anti-barrier breaker activity of marked intensity and duration; this efficacy was always dose-dependent.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D002229:Carbenoxolone / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D008564:Membrane Potentials / Q000187:drug effects; D010879:Piperazines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
D000897:Anti-Ulcer Agents; D010879:Piperazines; C042123:esaprazole; D002927:Cimetidine; D011899:Ranitidine; D002229:Carbenoxolone; D001241:Aspirin