The development and clinical use of acrylic strips containing anti-microbial agents in the management of chronic periodontitis.
Several methods have been used to deliver antimicrobial drugs into periodontal pockets. This study was concerned with the development of acrylic in strip form for such an application. Initially the release of chlorhexidine acetate from cold cured acrylic strips into water, was measured spectrophotometrically over a 15 day period. The release of chlorhexidine was highest on day 1, was reduced considerably by day 2 and then fell progressively to day 15. With the exception of the release on day 1 there was little difference in daily release from drug admixtures between 40 to 80 per cent. Comparison of the release of chlorhexidine, metronidazole and tetracycline demonstrated a similar release pattern for metronidazole and chlorhexidine but the daily release of tetracycline was considerably less. A bioassay indicated that all drugs were released in active form. In a clinical study chlorhexidine, tetracycline and metronidazole rods were placed in periodontal pockets for 2-3 days and the effects monitored by dark field microscopy. All drugs produced a proportional increase in cocci and marked reductions in other organisms, notably the curved and motile rods and spirochaetes. The effects of metronidazole and tetracycline were greater than those of chlorhexidine. A second clinical study compared the effects of metronidazole and tetracycline strips placed for 2 weeks. Clinically, both treatment methods had immediate effects upon pocketing, bleeding on probing and crevicular flow, which for metronidazole were maintained to the 3-month follow-up period. For tetracycline, the bleeding and crevicular flow were significantly reduced and maintained to the 3-month period but the initial pocket reduction returned to baseline levels by 3 months.(ABSTRACT TRUNCATED AT 250 WORDS)
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000187:drug effects; D018407:Bacterial Physiological Phenomena; D001439:Bacteroides / Q000187:drug effects; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004343:Drug Implants; D006801:Humans; D066298:In Vitro Techniques; D008795:Metronidazole / Q000008:administration & dosage / Q000494:pharmacology; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D011897:Random Allocation; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D008795:Metronidazole; D013752:Tetracycline; D002710:Chlorhexidine