Neonatal hypercalcemia in preterm infants fed with human milk.
Hypercalcemia (serum Ca greater than or equal to 2.83 mmol/l) was detected in 10 premature infants (gestational age: 31-37 weeks and birthweight: 1100-1950 g). All were fed with pooled human breast milk. Urinary Ca excretion was high (greater than 0.200 mmol/kg/24 h) in all but one infant while serum phosphorus (P) concentration and urinary P excretion were low. Serum immunoreactive parathyroid hormone and plasma 25-hydroxyvitamin-D concentrations were normal. A significant positive correlation was found between serum Ca concentration and urinary Ca excretion, and a negative correlation between serum Ca concentration and serum P concentration or urinary P excretion. Hypercalcemia disappeared spontaneously in two patients, was corrected by a humanized milk in three patients and by P supplementation in five patients. These data suggest that neonatal hypercalcemia is related to P depletion induced by human breast milk in premature infants.
D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood*; D008895:Milk, Human / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood
D010281:Parathyroid Hormone; D010710:Phosphates; D002112:Calcifediol; D002118:Calcium