Synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-3-hydroxypropylamine; an amino-estrogen with prolonged anticoagulant and brief estrogenic effects.
The synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-3-hydroxypropylamine, is described. It was characterized by ir, nmr, mass spectrometry and chemical analysis. The crystal structure of this compound was determined by single-crystal x-ray diffraction. Prolame belongs to space group P212121. Cell dimensions are: a = 8.356(2), b = 13.343(4) and c = 16.119(4) A. Z = 4; R = 4.1%.
D000925:Anticoagulants / Q000138:chemical synthesis*; D045166:Estradiol Congeners / Q000138:chemical synthesis*; D004963:Estrenes / Q000138:chemical synthesis*; D008958:Models, Molecular; D008968:Molecular Conformation; D014961:X-Ray Diffraction
D000925:Anticoagulants; D045166:Estradiol Congeners; D004963:Estrenes; C047867:prolame