A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA.
The T-cell antigen receptor is a cell surface molecule vital in mediating the cellular immune response. The arrangement and rearrangement of the gene segments encoding the beta-chain polypeptide of the receptor are similar to those of immunoglobulin gene segments. The two constant region genes of the human T-cell antigen receptor are 8 kilobases apart with a cluster of joining segments located 5' of each constant region gene. Although most beta-chain gene rearrangements involve the variable, diversity, and joining segments, analysis of a beta-chain complementary DNA clone suggests the occasional occurrence of another type of rearrangement.
D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic
D046911:Macromolecular Substances; D011948:Receptors, Antigen, T-Cell; D004247:DNA