Effects of isaxonine on skeletal muscle reinnervation in the rat: an electrophysiologic evaluation.
Electrophysiologic detection of the first signs of gastrocnemius muscle reinnervation shows that after a single localized freezing of the rat sciatic nerve, isaxonine does not significantly increase the rate of axonal regeneration. However, this drug does significantly enhance axonal sprouting, as it induces an increase of 50% in the number of muscle fibers with multiple innervation 10-30 days after freezing. After 30 days, the proportion of multiinnervated fibers decreases in both the control and isaxonine-treated rats, and the differences between them gradually disappear.
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011743:Pyrimidines; C020375:isaxonine