Amsacrine and etoposide induced paralytic ileus in a patient with acute myelomonocytic leukemia.
A 73-year-old man with acute myelomonocytic leukemia developed a severe paralytic ileus after amsacrine and etoposide treatment. The ileus did not respond to treatment with gastric suction and intravenous fluids. Autonomic neuropathy induced by anti-neoplastic drugs may lead to this life-threatening condition.
D000368:Aged; D000609:Aminoacridines / Q000009:adverse effects* / Q000627:therapeutic use; D000677:Amsacrine; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D005047:Etoposide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D011034:Podophyllotoxin / Q000031:analogs & derivatives*
D000609:Aminoacridines; D000677:Amsacrine; D005047:Etoposide; D011034:Podophyllotoxin