A combination of pirenzepine and cimetidine: a new approach to treatment of duodenal ulcer in "non-responders".
Treatment of peptic ulcer in "non-responders" with the combination of pirenzepine and cimetidine was evaluated in a longterm study. Patients who did not respond to two months of treatment, first with cimetidine (1 g/day), and then pirenzepine (150 mg/day), were given one of these two compounds alone for 6 months or a combination at lower doses for 24 months. The combination of pirenzepine (75 mg/day) and cimetidine (400 mg/day) was successful in a high percentage of cases, and showed fewer side effects than in the single treatment groups. The effectiveness of the combination treatment might be due to its more significant anti-secretory effects.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001570:Benzodiazepinones / Q000008:administration & dosage*; D002927:Cimetidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine; D013997:Time Factors
D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D010890:Pirenzepine; D002927:Cimetidine