Antiserum to lens antigens immunostains Müller glia cells in the neural retina.
Antiserum to a lens fraction enriched for alpha-crystallin selectively immunostains Müller glia cells in the neural retina of several vertebrate species. Also, in embryonic retina (chicken), this antiserum reacts with Müller cells and, at early stages of development, with their apparent precursors. Thus, antibodies to a lens product(s) detect a Müller glia cell marker that begins to be expressed very early in their ontogeny and can be useful in studies on differentiation, function, and pathologies of this cell type.
D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D003459:Crystallins / Q000032:analysis*; D007106:Immune Sera; D007908:Lens, Crystalline / Q000032:analysis / Q000166:cytology* / Q000196:embryology; D051379:Mice; D008970:Molecular Weight; D012160:Retina / Q000166:cytology*; D012165:Retinal Ganglion Cells / Q000166:cytology*; D013045:Species Specificity
D003459:Crystallins; D007106:Immune Sera