Monooxygenase induction by various xenobiotics and its influence on the rat liver microsomal metabolite profile of benz[a]anthracene.
Several pesticides (lindane, carbaryl, pentachlorophenol, DDT), polycyclic aromatic hydrocarbons (PAH) and heterocyclic analogues (fluoranthene, dibenz[a,h]anthracene, dibenz[a,h]acridine, indeno[1,2,3-cd]pyrene, 10-azabenzo[a]pyrene) and pharmaceuticals (diphenylhydantoin, ethinylestradiol, levonorgestrel) were tested for their potencies to induce monooxygenase activities in the rat liver by means of recording the metabolite profile of benz[a]anthracene in rat liver microsomal incubations. Some of them were found to be weak or moderate inducers, but even less efficient ones altered the benz[a]anthracene metabolite profile significantly. Only indeno [1,2,3-cd]pyrene stimulated the bay-region oxidation of benz[a]anthracene. A sex-dependent metabolism was observed in both untreated and contraceptive-pretreated Wistar rats.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D010105:Oxygenases / Q000096:biosynthesis*; D010575:Pesticides / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D001551:Benz(a)Anthracenes; D010575:Pesticides; D011083:Polycyclic Compounds; C030935:benz(a)anthracene; D010105:Oxygenases; D010634:Phenobarbital