Effect of alpha-methyldopa excreted in human milk on the breast-fed infant.
A nursing infant whose mother took alpha-methyldopa (alpha-MD) was followed for 3 months. Analysis of maternal serum and milk as well as the infant's serum and urine for alpha-MD revealed that the drug was excreted into maternal milk, absorbed by the infant and excreted in her urine, but no adverse clinical effects were noted during the follow-up period. alpha-MD is excreted in human milk in concentrations that probably do not harm the breast-fed infant.
D000328:Adult; D001942:Breast Feeding; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D007231:Infant, Newborn; D007700:Kinetics; D008750:Methyldopa / Q000097:blood* / Q000627:therapeutic use; D008895:Milk, Human / Q000378:metabolism*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000097:blood* / Q000188:drug therapy
D008750:Methyldopa