The radiomimetic properties of a platinum drug.
CHIP (cis-dichlorobis isopropylamine trans-dihydroxy platinum IV) is a second-generation platinum co-ordination complex which potentiates the effects of radiation. Comparisons of the biological effects of CHIP and X rays upon Chinese hamster (ovary) cells have shown similarities with respect to the shape of the dose-response curves, clone size distributions and perturbation of the cell cycle. Unlike irradiated cells however, CHIP-treated cells showed no recovery from sublethal damage and no variation in sensitivity throughout the cell cycle. CHIP is a radiomimetic drug in some respects but not in others.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D066298:In Vitro Techniques; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010053:Ovary
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin