Assessment of antiprotease activity of some carbamate derivatives.
Six carbamate derivatives were tested for inhibitory activity towards porcine pancreatic elastase, trypsin, and chymotrypsin. Only three esters that are isatoic anhydride derivatives were found to inhibit elastase competitively but nonspecifically. KI values for the best two inhibitors were determined from Dixon plots.
D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D007700:Kinetics; D008970:Molecular Weight; D010179:Pancreas / Q000201:enzymology; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D013552:Swine; D014361:Trypsin Inhibitors / Q000138:chemical synthesis
D002219:Carbamates; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D010196:Pancreatic Elastase