Biphenomycins A and B, novel peptide antibiotics. II. Structural elucidation of biphenomycins A and B.
The structures of biphenomycins A and B, novel peptide antibiotics produced by a strain of Streptomyces, have been established as 1 and 2, respectively, on the basis of spectroscopic and chemical evidence. They are unique in that they are cyclic peptides containing a biphenyl moiety included in a 15-membered ring and show potent antibacterial activities especially against Gram-positive bacteria.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004151:Dipeptides; D010455:Peptides; D010456:Peptides, Cyclic; C047537:biphenomycin B; C047536:biphenomycin A