[Prevention of gastroduodenal stress lesions with secretion inhibitors in accident patients needing intensive care: incidence of lesions and adverse effects; consequences].
Prevention of gastrointestinal stress lesions by cimetidine or pirenzepine was investigated in a double blind study of trauma patients in an intensive care unit. Cimetidine or pirenzepine were administered intravenously to 55 consecutive randomized patients. All were checked by endoscopy on admission and 8 days later. 5 therapy failures were found in each group. Patients with more than 5 erosions and/or ulcerations were classified as failures. A side effect encountered was sinus tachycardia in 4 of 27 patients treated with pirenzepine. Overall, a trend towards fewer stress lesions was found in the pirenzepine protected group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use*; D003422:Critical Care; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D010890:Pirenzepine; D013312:Stress, Physiological / Q000150:complications*; D014947:Wounds and Injuries / Q000150:complications*
D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D010890:Pirenzepine; D002927:Cimetidine
Prophylaxe gastroduodenaler Stressläsionen bei intensivpflegebedürftigen Unfallpatienten mit Sekretionshemmern: Inzidenz von Läsionen und Nebenwirkungen; Konsequenzen.