Abierixin, a new polyether antibiotic. Production, structural determination and biological activities.
A new polyether antibiotic, abierixin, was found in the mycelium of a culture broth of nigericin-producing Streptomyces albus NRRL B-1865. Abierixin was extracted with organic solvents and purified by column chromatography and HPLC. The structure of abierixin was determined by FAB/MS/MS and CI/MS/MS and 1H and 13C NMR spectrometries. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Nigericin biosynthesis from abierixin is discussed.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D004539:Eimeria / Q000187:drug effects; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D009550:Nigericin / Q000378:metabolism; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011714:Pyrans; C047796:abierixin; D009550:Nigericin