Biological activity of the three mono-beta-D-glucopyranosides of 1,25-dihydroxycholecalciferol.
The biological activity of the three mono-beta-D-glucopyranosides (mono-glucosides) of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] synthesized chemically has been studied in chicks and Japanese quails. While the 1- and the 3-glucoside showed no or only little effect on serum calcium, bone weight, calcium binding protein (CaBP) or calcium deposition in the egg shell, the 25-glucoside was found to be more than half as active as the aglycone 1,25(OH)2D3. The bioactivity of this glucoside parallels a higher binding constant to the intestinal 1,25(OH)2D3 receptor compared to those of the two other glucosides.
D000818:Animals; D017317:Annexin A6; D001842:Bone and Bones / Q000187:drug effects; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002645:Chickens; D003370:Coturnix; D004528:Egg Shell; D005260:Female; D008297:Male; D012279:Rickets / Q000188:drug therapy; D013810:Therapeutic Equivalency
C028780:1,25-dihydroxycholecalciferol glycoside; D017317:Annexin A6; D002135:Calcium-Binding Proteins; D002117:Calcitriol; D002118:Calcium