The segregation-linkage analysis of genetically determined characters.
The model of combined segregation-linkage analysis is presented. The method offers the opportunity of simultaneous estimation of recombination fraction between the locus of genetic marker and that of a disease gene and the evaluation of its inheritance pattern. The computer programme MUBAS estimates combinations of parameters: dominance-d, penetrance-t and recombination fraction by the method of maximum likelihood using the distribution of the observed numbers of sib pairs: ill/proband and healthy/proband.
D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D012984:Software