First experience in the treatment of human hydatid disease with mebendazole.
The authors report their experience with mebendazole in human hydatid disease. Following a WHO-controlled protocol, 25 patients with hydatidosis were treated with mebendazole, 50 mg/kg/die for 4-8 months. A further 2 patients were treated with mebendazole 30 mg/kg/die for 6 months, outside the WHO protocol. The evaluation of the results was performed by clinical, radiological (X-ray, ultrasounds, computerized tomography) and immunological investigations (monitoring of indirect haemoagglutinating antibodies, specific IgE, lymphocytic blastization, circulating immune complexes, etc.). The results were encouraging and the side-effects were not important; nevertheless, many questions remain to be elucidated.
D004443:Echinococcosis / Q000188:drug therapy*; D004444:Echinococcosis, Hepatic / Q000188:drug therapy; D004445:Echinococcosis, Pulmonary / Q000188:drug therapy; D006801:Humans; D008463:Mebendazole / Q000009:adverse effects / Q000627:therapeutic use*
D008463:Mebendazole