Selective expression of adult beta-globin but not embryonic y-globin genes in hybrids of mouse yolk-sac and erythroleukemia cells.
Hybrid cells from mouse erythroleukemia and yolk-sac cells from 12-day-old mouse embryos were formed, and the expression of adult beta-globin and embryonic y-globin genes was examined. In these hybrid cells, hemoglobin synthesis could be induced by the addition of dimethylsulfoxide. The adult beta-globin genes from both parental chromosomes were expressed, but embryonic y-globin genes were not. These results suggest that the expression of adult genes dominates that of embryonic genes.
D000818:Animals; D005786:Gene Expression Regulation; D005914:Globins / Q000096:biosynthesis / Q000235:genetics*; D006822:Hybrid Cells / Q000378:metabolism / Q000502:physiology*; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics* / Q000473:pathology; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D015017:Yolk Sac / Q000166:cytology / Q000502:physiology*
D012333:RNA, Messenger; D005914:Globins