Biological properties of benzodifuran derivatives.
The antiviral activity and the effect on DNA synthesis of two benzodifuran compounds were studied. DNA and some RNA viruses were significantly inhibited by concentrations ranging from 15 to 30 nM/ml. The inhibition of DNA synthesis in host cells was obtained with concentrations higher than those inhibiting virus replication. A favourable ratio between antiviral activity and inhibition of DNA synthesis of the host cells is present in these compounds. This activity is substantially due to the ability of the compounds to complex with DNA.
D000818:Animals; D000998:Antiviral Agents; D001572:Benzofurans / Q000494:pharmacology*; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D004267:DNA Viruses / Q000502:physiology; D004279:DNA, Viral / Q000096:biosynthesis; D051379:Mice; D012328:RNA Viruses / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001572:Benzofurans; D004279:DNA, Viral