PD 118,576: a new antitumor macrolide antibiotic.
The isolation and properties of PD 118,576, a new cytotoxic antibiotic obtained from the culture broth of a Streptomyces sp., are described. The structure of this compound was established by spectral analyses of the parent compound and its tri-O-acetyl derivative. PD 118,576 proved to be related to the bafilomycins and therefore is a new member of this recently discovered family of macrolide antibiotics.
D000107:Acetylation; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D007659:Ketones / Q000302:isolation & purification; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D007659:Ketones; D018942:Macrolides; C047535:PD 118576