Pharmacokinetic lag time estimation.
This note draws attention to a problem encountered when using the pharmacokinetic computer program CSTRIP for lag time estimation. The problem arises because data belonging to the lag phase is used for polyexponential parameter estimation. Simulated data are used to illustrate the effect on the fitted curve. A new curve stripping program JANA is shown to be free of this flaw.
D001699:Biometry; D003201:Computers; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012984:Software
D004364:Pharmaceutical Preparations