Potentiation of the anthelmintic activity of oxfendazole by parbendazole.
The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35-36.0 mg/kg) of doses of PBZ with 4.53 mg OFZ/kg demonstrated that significant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the area under the plasma OFZ concentration curve was about twice that obtained from oral administration of OFZ alone. When tested against benzimidazole-resistant Haemonchus contortus and Trichostrongylus colubriformis, the mixture of 4.5 mg PBZ + 4.53 mg OFZ/kg was significantly more effective than 4.53 mg OFZ/kg alone, and PBZ alone showed no activity against these resistant nematodes. The demonstration of PBZ-OFZ potentiation has indicated a means of obtaining a more effective use of currently available anthelmintics in the treatment of helminthiasis.
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D007700:Kinetics; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D010949:Plasma / Q000378:metabolism; D012756:Sheep / Q000097:blood; D012757:Sheep Diseases / Q000188:drug therapy
D000871:Anthelmintics; D001562:Benzimidazoles; C100292:parbendazole; C011030:oxfendazole