Effects of the intraperitoneal administration of diazepam on rat serum lipoproteins separated by polyacrylamide gel electrophoresis.
In normolipidaemic young rats the intraperitoneal administration of diazepam (10 mg/kg) induced a marked fall of the total serum lipids and total cholesterol. A dose of 5 mg/kg brought about an increase of HDL2 lipoprotein fraction and an elevation of the HDL2/HDL2.HDL3 ratio. Margarine administration elicited a significant augmentation of the total serum lipids and a reduction of the HDL2/HDL2.HDL3 ratio. The intraperitoneal injection of diazepam in margarine-treated rats brought about a decrease of total serum lipids and total cholesterol, (when compared to the margarine values), an obvious elevation of the HDL2 fraction and of HDL2/HDL2.HDL3 ratio. The LDL1 (beta) fraction was decreased. These data confirm our earlier findings which show that diazepam improves the HDL cholesterol/total cholesterol ratio.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D007274:Injections, Intraperitoneal; D008074:Lipoproteins / Q000097:blood* / Q000302:isolation & purification; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008074:Lipoproteins; D002784:Cholesterol; D003975:Diazepam