Effect of copper on blood serum xanthine dehydrogenase in rats given D-L-ethionine.
Hepatic lesions by D-L-ethionine in rats produce a significant increase in the blood serum xanthine dehydrogenase activity. Cupric acetate is a potent inhibitor (Ki = 3.42 X 10(-6) M) of the xanthine dehydrogenase activity. Ethionine protects against the inhibitory effect of cupric acetate by formation of a copper complex with behaviour different from that of free ethionine.
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D005001:Ethionine / Q000494:pharmacology*; D005260:Female; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects; D009942:Organometallic Compounds; D051381:Rats; D014968:Xanthine Dehydrogenase / Q000037:antagonists & inhibitors* / Q000097:blood
D009942:Organometallic Compounds; C015092:cupric acetate; D003300:Copper; D014968:Xanthine Dehydrogenase; D007658:Ketone Oxidoreductases; D005001:Ethionine