Avascular zone in the macula in cicatricial retinopathy of prematurity.
Avascular zones in the maculas of 49 eyes of 33 patients aged 5 to 15 years with cicatricial retinopathy of prematurity were examined by fluorescein angiography. Twenty-three eyes of 18 subjects under 15 years of age who had been born at full term served as controls. The mean diameter of the avascular zones in the patients was 0.22 +/- 0.09 disk diameter, which was smaller than the diameter of 0.32 +/- 0.05 disk diameter in the controls (P less than .001). The patient group was divided into those with avascular zones of 0.2 disk diameter or less, regarded as underdeveloped avascular zones, and those with zones of 0.21 disk diameter or more, considered well-developed avascular zones. In the first group, ocular manifestations in the active stage were statistically more severe than in the second group. Visual acuity was good in most patients in each group.
D000293:Adolescent; D001724:Birth Weight; D002648:Child; D002675:Child, Preschool; D005451:Fluorescein Angiography; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008266:Macula Lutea / Q000098:blood supply* / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D012178:Retinopathy of Prematurity / Q000145:classification / Q000473:pathology*