The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
The antinociceptive responses to the gamma-aminobutyric acid receptor agonists THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol) and baclofen were examined in spinally transected mice to define the central nervous system site of action for these drugs. Nociception was assessed using a tail-immersion assay. The results indicated that spinal transection (T6-T10) completely abolished the antinociceptive responses to THIP and baclofen, attenuated those to oxotremorine and morphine, but did not reduce the response to clonidine. The results suggest that the antinociceptive responses to THIP and baclofen are mediated by an action at supraspinal sites rostral to T6.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology; D002818:Cordotomy; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D010080:Oxazoles / Q000494:pharmacology*; D010095:Oxotremorine / Q000494:pharmacology
D000700:Analgesics; D007555:Isoxazoles; D010080:Oxazoles; D010095:Oxotremorine; D009020:Morphine; D001418:Baclofen; C015542:gaboxadol; D003000:Clonidine