Oral controlled-release delivery of ivermectin in cattle via an osmotic pump.
Ivermectin, a potent antiparasitic agent with activity against internal and external parasites, was delivered to cattle at a controlled zero-order rate for 35 d via orally administered, specially weighted, ALZET 2ML4 osmotic pumps. The osmotic pumps delivered the drug consistently over the trial period. Steady-state levels in plasma were achieved in 7-14 d, and plasma concentration depletion curves were observed to start at approximately day 35, the theoretical delivery lifetime of the osmotic pumps. Bioavailability was estimated to be 40%, and dose rate-plasma steady-state interrelationships were shown to be linear.
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000097:blood; D002417:Cattle; D003692:Delayed-Action Preparations; D004343:Drug Implants; D005260:Female; D007559:Ivermectin; D007700:Kinetics; D007783:Lactones / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008823:Micelles
D000981:Antiprotozoal Agents; D003692:Delayed-Action Preparations; D004343:Drug Implants; D007783:Lactones; D008823:Micelles; D007559:Ivermectin