Reduced sleep in cats after intraperitoneal injection of delta-sleep-inducing peptide (DSIP).
The effect of intraperitoneally injected delta-sleep-inducing peptide (DSIP) on sleep-wakefulness in cats was studied using EEG, EMG and EOG recording for 10 h following 30 nmol/kg DSIP or control saline i.p. injections. DSIP reduced the amount of sleep, specifically light slow-wave sleep and REM sleep, and REM sleep latency was increased. The results suggest that in cats with redundancy sleep DSIP increases wakefulness at the cost of light slow-wave sleep, and in addition it has a specific REM-reducing effect.
D000818:Animals; D002415:Cats; D003701:Delta Sleep-Inducing Peptide; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011930:Reaction Time; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide