Influence of cyclosporin A, dexamethasone, and benzalkonium chloride (BAK) on corneal epithelial wound healing in the rabbit and guinea pig eye.
Corneal erosions were produced by iodine vapor application in rabbit and guinea pig eyes. The corneal erosion of each eye was photographed four times daily after fluorescein staining and the erosion area measured planimetrically. Thirty-six percent of the corneal epithelium was destroyed in rabbits and 67% in guinea pigs. In guinea pigs, wound healing was delayed significantly by Spersadex, Totocortin, and benzalkonium chloride (BAK) 0.01% in the experimental eye. Spersadex also caused a significant delay in wound healing in the nontreated contralateral eye. Cyclosporin A 2% and Oculotect had no influence on epithelial wound healing. An 8-day pretreatment of guinea pig eyes with cyclosporin A or Spersadex had no further influence on the epithelial wound-healing rate.
D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D002057:Burns, Chemical / Q000188:drug therapy; D003524:Cyclosporins / Q000494:pharmacology* / Q000627:therapeutic use; D003907:Dexamethasone / Q000494:pharmacology* / Q000627:therapeutic use; D004848:Epithelium / Q000187:drug effects; D005126:Eye Burns / Q000188:drug therapy; D006168:Guinea Pigs; D007455:Iodine; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D001548:Benzalkonium Compounds; D003524:Cyclosporins; D003907:Dexamethasone; D007455:Iodine