Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters.
T-2 toxin given as a single intravascular dose to swine produced a shock syndrome. Dosages of 0.6 or 4.8 mg/kg were administered to different groups of swine. Shock was characterized by reductions in cardiac output and blood pressure, and increased plasma concentrations of epinephrine, norepinephrine, thromboxane B2, 6-keto PGF1 alpha, and lactate. Total peripheral resistance was unchanged in the high-dose group but decreased in the low-dose group. Pulmonary vascular resistance increased in both groups. Decreases occurred in arterial pH and arterial oxygen partial pressure. No alterations occurred in plasma concentrations of histamine or serotonin.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012717:Sesquiterpenes / Q000633:toxicity*; D013552:Swine; D013605:T-2 Toxin / Q000633:toxicity*; D013929:Thromboxane B2 / Q000097:blood; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D002395:Catecholamines; D012717:Sesquiterpenes; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013605:T-2 Toxin