Distal renal tubular acidosis and lymphocytic thyroiditis with spontaneously resolving hyperthyroidism. Report of 1 case without nephrocalcinosis.
In a 33-year-old woman concurrence of a complete distal renal tubular acidosis (RTA) and lymphocytic thyroiditis with spontaneously resolving hyperthyroidism was observed. Until recently, the rare association of RTA and hyperthyroidism had been thought to be governed by nephrocalcinosis, via hypercalcemia and hypercalciuria. However, in this case, nephrocalcinosis was not present, but there were histological signs of renal interstitial mononuclear cell infiltration, and the RTA persisted despite the resolution of the hyperthyroidism. This observation supports the idea that immunological mechanisms may relate RTA and hyperthyroidism when the latter has an autoimmune origin.
D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000276:immunology; D000328:Adult; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000276:immunology; D007111:Immunity, Cellular; D009397:Nephrocalcinosis; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000276:immunology