Assessment of the pyrogenic potency of the thromboxane A2-mimetics, SQ26655 and U46619, and thromboxane B2 by intrapreoptic injection in the cat.
Using bilateral injection into the anterior hypothalamic/preoptic region of the conscious, indomethacin pretreated cat as an assay system, the pyrogenic activity of two thromboxane A2-mimetics (SQ26655 and U46619) and thromboxane B2 was assessed. PGE2 was used as a reference pyrogenic agent. Thromboxane B2 and both of the thromboxane A2-mimetics were at least 5263 times less potent than PGE2. The results do not support the putative role of thromboxanes as mediators of fever.
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D002415:Cats; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D008297:Male; D011301:Preoptic Area / Q000187:drug effects; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011749:Pyrogens / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000031:analogs & derivatives*; D013929:Thromboxane B2 / Q000494:pharmacology*
D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D011450:Prostaglandin Endoperoxides, Synthetic; D011458:Prostaglandins E; D011749:Pyrogens; D013929:Thromboxane B2; D013928:Thromboxane A2; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; C032408:SQ 26536; D015232:Dinoprostone