Inhibition by pesticides of prostaglandin formation in blood platelets.
Aggregation of human platelets was investigated after pre-incubation of platelet rich plasma with various pesticides of the carbamate type. Whereas N-methyl-carbamates (insecticides) inhibited the arachidonic acid induced aggregation, N-phenyl-carbamates (herbicides) had no effect. The influence of the different carbamates on aggregation coincided with their inhibition of thromboxane B2-formation. - DDE, a metabolite of the insecticide DDT, affected aggregation to a similar extent as N-methyl-carbamates. DDT, however, had no inhibitory activity.
D001792:Blood Platelets / Q000378:metabolism*; D002219:Carbamates; D003634:DDT / Q000494:pharmacology*; D006801:Humans; D007306:Insecticides / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*
D002219:Carbamates; D007306:Insecticides; D011453:Prostaglandins; D003634:DDT