Relationship between zinc and prostaglandin metabolisms in plasma and small intestine of rats.
The effect of zinc nutriture on levels of prostaglandin (PG) E2, F2 alpha and 6-keto-PGF1 alpha in the plasma and small intestine of rats, and that of PGE2 and PGF2 alpha on unidirectional uptake of 65Zn by everted gut sac of rats was determined. When zinc was given intraperitoneally, plasma PGE2 and intestinal PGF2 alpha levels increased, while the intestinal PGE2 and the plasma PGF2 alpha and 6-keto-PGF1 alpha levels decreased in accordance with the amount of zinc given. Oral administration of excess zinc increased intestinal PGE2, PGF2 alpha and 6-keto-PGF1 alpha levels and the plasma 6-keto-PGF1 alpha levels. The intestinal levels of PGE2 increased significantly only in rats on zinc excess diet, and of PGF2 alpha only in rats on a zinc deficient diet. The plasma PGE2 levels in rats on both zinc deficient and zinc excess diets increased but PGF2 alpha levels in zinc deficient rats were greatly reduced compared to controls. Unidirectional zinc uptake by everted gut sac of the rat is also enhanced by PG metabolites. These results are consistent with the view that PGs participate in regulating the zinc transport mechanism in small intestine.
D000284:Administration, Oral; D000818:Animals; D001692:Biological Transport; D015232:Dinoprostone; D005260:Female; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D011458:Prostaglandins E / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000097:blood / Q000172:deficiency / Q000378:metabolism*
D011458:Prostaglandins E; D011460:Prostaglandins F; D015032:Zinc; D015232:Dinoprostone