Morphometric and histological examinations of dog kidneys after embolization of the renal artery with the cyanoacrylic glue "Chirurcoll-Polfa".
The renal artery in 20 mongrel dogs was embolized with cyanoacrylic glue "Chirurcoll-Polfa", introduced through a catheter. The extent of the resulting renal infarction of the kidneys was evaluated morphometrically and was found to be 71.35 to 91.43% of the volume of the embolized kidneys (mean 77.61%). Histological examinations revealed no resorption of the glue after 3 months. In the embolized vessels, after 7 days tumefaction and degeneration of the reticulin, elastic, and collagen fibres were observed, after 24 days inflammatory changes, and after 2 and 3 months respectively, secondary collagenization and hyalinization. Inflammatory changes were also found in the perivascular tissue. In the sections of the kidneys not involved in the infarction a progressive atrophy of the nephrons and fibrosis of the parenchyma were observed 2 and 3 months after embolization.
D000818:Animals; D001284:Atrophy; D004285:Dogs; D004621:Embolization, Therapeutic; D004659:Enbucrilate / Q000633:toxicity*; D007238:Infarction / Q000139:chemically induced* / Q000473:pathology; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D012077:Renal Artery / Q000473:pathology
D004659:Enbucrilate