Genetic engineering in the Precambrian: structure of the chicken triosephosphate isomerase gene.
We report the sequence of the single chicken triosephosphate isomerase gene and its flanking regions. The 3-kilobase-long gene is composed of seven similarly sized exons and six introns. By using crystallographic and sequence data, we argue that this ancient gene was originally assembled from the genetic antecedents of exons.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002238:Carbohydrate Epimerases / Q000235:genetics*; D002645:Chickens / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D011487:Protein Conformation; D011770:Pyruvate Kinase / Q000235:genetics; D013045:Species Specificity; D014305:Triose-Phosphate Isomerase / Q000235:genetics*
D004247:DNA; D011770:Pyruvate Kinase; D002238:Carbohydrate Epimerases; D014305:Triose-Phosphate Isomerase