Effect of an expanded physical facility on nosocomial infections in a neonatal intensive care unit.
Fifty-two months' data were reviewed to assess the effect of a threefold increase in space per infant in a neonatal intensive care unit on rates of nosocomial infections (NIs) and colonization with Staphylococcus aureus (39 months in a crowded 18-bed unit and 13 months in a spacious 32-bed unit). Mean length of stay, survival rates, mean birth weights, and other parameters indicated that infant populations in the old and new units were similar. NI rates were not significantly different in the old and new units (11.7% and 9.6%, respectively; p = 0.17) nor were rates of colonization of anterior nares with S. aureus (11.7% and 10.7%; p = 0.5). NI rates, but not S. aureus colonization rates, were significantly higher during months of high patient turnover (p less than 0.01). Sites of infection were similar in the old and new units. There was, however, a significant change in bacterial species causing NI. Klebsiella pneumoniae and Pseudomonas aeruginosa caused 20.4% of NIs in the old unit, but only 2.1% in the new unit (p less than 0.001) and NIs caused by S. epidermidis increased from 4.7% to 14.9% (p = 0.02) in the new unit. There was also a marked decrease in the numbers of clusters of NI occurring in the new unit, indicating that cross-infections between infants were probably minimized.
D003428:Cross Infection / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D006745:Hospital Bed Capacity, 300 to 499; D006749:Hospital Design and Construction; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000453:epidemiology; D007363:Intensive Care Units, Neonatal; D008297:Male; D012306:Risk; D014861:Washington