Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.
The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000032:analysis*; D006801:Humans; D009369:Neoplasms / Q000032:analysis*; D010455:Peptides / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D015291:Transforming Growth Factors
D010455:Peptides; D012333:RNA, Messenger; D015291:Transforming Growth Factors; D004247:DNA