Issues of methodology and interpretation in clinical and animal behavioral teratology studies.
Selected methodological issues of appropriate control procedures and dose-response relationships are discussed with respect to the issue of interpretation. Neuropsychiatric effects in infants and children following prenatal exposure to alcohol or the opioids are compared with effects reported in animals.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D003932:Heroin / Q000633:toxicity; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced*; D008691:Methadone / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013045:Species Specificity; D013723:Teratogens / Q000633:toxicity*
D013723:Teratogens; D003932:Heroin; D008691:Methadone