A dose-response study of piloplex for duration of action.
The duration of reduction in intraocular pressure after single-dose administration of three concentrations of piloplex and the vehicle of the drug was evaluated in 12 patients with open-angle glaucoma in a randomized, double-masked, crossover study. Piloplex lowered intraocular pressure in a dose-related fashion, with a duration of action of at least 14 hours.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure; D010862:Pilocarpine / Q000008:administration & dosage*
D010862:Pilocarpine; C018639:Piloplex