Identity-by-descent analysis of sibship configurations.
This study considers configurations of identity-by-descent sharing in sibships as an alternative to breaking the sibship into sib pairs. A general method is presented for specifying all distinct configurations and deriving their probabilities. The method works for sibships of arbitrary size and can be implemented with paper and pencil. Specific results are given for sibships up to size six. Applications for disease-marker studies are discussed.
D030342:Genetic Diseases, Inborn / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D005826:Genetics, Medical; D006801:Humans; D008957:Models, Genetic
D005819:Genetic Markers