Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.
Cells transformed by Harvey or Moloney sarcoma virus secrete at least 40 times as much type beta transforming growth factor as their respective untransformed control cells. The transformed cells bind only 20 to 50% as much type beta transforming growth factor as the control cells, suggesting that transformation causes down-regulation of the type beta transforming growth factor receptor.
D001681:Biological Assay; D002472:Cell Transformation, Viral; D003470:Culture Media / Q000032:analysis; D006133:Growth Substances / Q000378:metabolism*; D006251:Harvey murine sarcoma virus; D008980:Moloney murine sarcoma virus; D010455:Peptides / Q000378:metabolism*; D011869:Radioligand Assay; D015291:Transforming Growth Factors
D003470:Culture Media; D006133:Growth Substances; D010455:Peptides; D015291:Transforming Growth Factors