Effective treatment with coenzyme Q10 of patients with chronic myocardial disease.
Nineteen patients with chronic myocardial disease (NYHA Classes III and IV) were given Coenzyme Q10 in a controlled double-blind cross-over study. All had either low or borderline levels of CoQ10 in their blood, and showed a significant change into the normal range with oral CoQ10 replacement. Eighteen patients reported improvement in activity tolerance with replacement therapy. Combined clinical observations, stroke volume measured by impedance cardiography, and ejection fractions calculated from systolic time intervals, all showed significant improvement in parallel with CoQ10 administration. This application of the principles of bioenergetics introduces a promising new dimension to the study and treatment of the complex problem of myocardial failure.
D009202:Cardiomyopathies / Q000188:drug therapy*; D002908:Chronic Disease; D003067:Coenzymes; D004311:Double-Blind Method; D004562:Electrocardiography; D006801:Humans; D011897:Random Allocation; D013318:Stroke Volume / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10