[Transference of cefmenoxime from serum to lung tissue].
Ten patients who were performed pulmonary resection for the disease of the lung, were administered 2 g of cefmenoxime (CMX) by intravenous injection before their operation. The concentrations of CMX in serum and lung tissue were determined. The CMX concentrations in lung tissue were observed to be higher than the MIC of CMX for Klebsiella pneumoniae, Haemophilus influenzae and Serratia. These results suggested that CMX will be useful agent for the prevention and treatment of pulmonary infection.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control; D015281:Cefmenoxime; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism*; D008171:Lung Diseases / Q000601:surgery*; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control
D015281:Cefmenoxime; D002439:Cefotaxime