Unusual Ph translocations in the French prospective study on chronic myeloid leukemia. Groupe Français de Cytogénétique Hématologique.
In a prospective and collaborative cytogenetic study of chronic myelocytic leukemia (CML) in France, 234 new patients were collected in 3 yr. A standard Ph chromosome was present in 80.7% of the cases; 13.1% of the patients had additional chromosomal abnormalities, and 5.9% of the patients had an unusual Ph translocations (3 simple, 11 complex). Geographical differences in the incidence of the unusual Ph translocations were present.
D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005602:France; D006801:Humans; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000235:genetics*; D014178:Translocation, Genetic