Inhibition of cholesterol biosynthesis by BM 15.766.
BM 15.766 (4-[2-[1-(4-chlorocinnamyl)piperazin-4-yl]ethyl]benzoic acid) showed a dose dependent action on 14C-acetate incorporation in cholesterol and intermediates including squalene by adult rat hepatocytes in primary monolayer culture. The biosynthesis of cholesterol could be reduced by more than 90%. Simultaneously, the 7-dehydrocholesterol level rose in the cells and, to a less marked extent, in the culture medium.
D000818:Animals; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood*; D003470:Culture Media; D003684:Dehydrocholesterols / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000378:metabolism*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats
D003470:Culture Media; D003684:Dehydrocholesterols; D010879:Piperazines; C047457:BM 15766; D002784:Cholesterol; C016705:7-dehydrocholesterol