Screening of toxic-haemolytic anaemia in laboratory rats: a model of phenylhydrazine-induced haemolysis.
An increase of the plasma haemoglobin level was found to be a reliable characteristic of toxic-haemolytic anaemia induced by a single dose of phenylhydrazine in laboratory rats. Very high doses of the substance increased the changes in many other characteristics to an extent that was up to now observed only for haemolytic events.
D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D009929:Organ Size; D010659:Phenylhydrazines / Q000633:toxicity*; D051381:Rats; D013154:Spleen / Q000033:anatomy & histology
D006454:Hemoglobins; D010659:Phenylhydrazines; C030299:phenylhydrazine