Hb Regina or alpha 2 beta 2 96(FG3)Leu----Val: a high oxygen affinity variant discovered by cation-exchange HPLC.
Results are reported of studies of the hemoglobin from one member of a Canadian family with a mild erythrocytosis. This variant, which accounted for about 40% of the hemoglobin, could be separated from Hb A and Hb A2 by cation-exchange chromatography. Micro methodology allowed the characterization of a Leu----Val replacement at position beta 96(FG3). Hb Regina has an increased oxygen affinity, which adequately explains the hematological observations.
D000328:Adult; D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D006455:Hemoglobins, Abnormal / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D010446:Peptide Fragments / Q000302:isolation & purification; D011086:Polycythemia / Q000097:blood
D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; C045502:hemoglobin Regina; D010100:Oxygen