[Noninvasive estimates of pulmonary hypertension and study of the etiology of ejection flow velocity profiles].
Flow velocities at the right ventricular outflow tract were recorded for 36 patients including 12 with pulmonary hypertension. Doppler indexes [right ventricular preejection period (RPEP), right ventricular ejection time (RET), right ventricular acceleration time (RAT), RPEP/RET, RET/RAT] were calculated from flow velocity profiles, and noninvasive estimation of pulmonary hypertension was attempted using these indexes. The etiology of ejection flow velocity in pulmonary hypertension was studied using a simulation model. The following results were obtained. RAT shortened proportionately with an increase of pulmonary arterial pressure. RET/RAT correlated most significantly with pulmonary arterial pressure (r = 0.83, p less than 0.001). RET/RAT correlated inversely with stroke volume (SV) (r = -0.48, p less than 0.01); therefore, attention should be paid to SV, when estimating pulmonary arterial pressure, using the value of RET/RAT. The diagnostic value for pulmonary hypertension using RET/RAT was excellent; the predictive accuracy was 100%, sensitivity 75%, and specificity 100%, and it was possible to evaluate pulmonary hypertension using this method. According to the simulation model, an increase of both the pulmonary pulse wave velocity and the reflection of the pulse wave made the interval between the onset and the time of the peak flow velocity shorter. A flow velocity pattern similar to that of pulmonary hypertension was obtained.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D013318:Stroke Volume