Guanine-7-oxide, a novel antitumor antibiotic.
A new antibiotic, PD 113,876, was isolated from the culture broth of a Streptomyces sp. and was shown by X-ray diffraction analysis to be the N-7 oxide of guanine. This novel antimetabolite is very active in vivo against L1210 lymphocytic leukemia.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006147:Guanine / Q000031:analogs & derivatives* / Q000302:isolation & purification; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D013302:Streptomyces / Q000378:metabolism*; D014961:X-Ray Diffraction
D000903:Antibiotics, Antineoplastic; C046075:guanine 7-oxide; D006147:Guanine