Structure and progestational activity of 13-substituted-18-norpregn-4-ene-3, 20-diones, a pilot study.
13-Ethyl-18-norpregn-4-ene-3, 20-dione (7) and 13-acetyl-18-norpregn-4-ene-3, 20-dione (4) were synthesized and tested in the s.c. Clauberg assay. The potencies of these compounds (1X and 1/3 X progesterone, respectively) are compared with those reported for 13-vinyl- and 13-cyanomethyl-18-norpregn-4-ene-3, 20-dione. A comparable activity (1/3 X progesterone) was found for 13-acetyl-18-norpregn-4-en-3-one (10) which lacks the 20-carbonyl group.
D000818:Animals; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D007202:Indicators and Reagents; D009652:Norpregnenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009904:Optical Rotation; D011374:Progesterone / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009652:Norpregnenes; D011374:Progesterone