Sodium bisulfite protects against radiogenic and chemically induced transformation in hamster embryo and mouse C3H/10T-1/2 cells.
Pretreatment of hamster embryo cells or mouse C3H/10T-1/2 cells with sodium bisulfite (0.5, 2.5, 5.0 and 100 ppm) inhibits the oncogenic transformation of the cells following their exposure to x-rays or benzo(a)pyrene. The results suggest that low doses of bisulfite, a widely used food additive, can serve as a radioprotective and chemopreventive agent with anticarcinogenic potential.
D000818:Animals; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D051379:Mice; D008809:Mice, Inbred C3H; D011837:Radiation-Protective Agents; D013447:Sulfites / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D013447:Sulfites; D001564:Benzo(a)pyrene; C009279:sodium bisulfite