[Effect of a live tularemia vaccine on chemical mutagenesis in white rats].
The influence of immunization with tularemic live dry vaccine applied singularly to Wistar rats skin on mutagenicity induced by cyclophosphamide, methylnitrosourea, benzo (a) pyrene, chloroprene and tetrachlorbutane was studied. The chemical compounds indicated were injected intraperitoneally at doses equal to one fifth of LD50 in 15 days after vaccination. The same doses of these chemicals were applied to intact rats (controls). Metaphase plates were prepared from rat bone marrows by known methods, 9600 metaphase cells were studied in total. The analysis showed that cytogenetic disturbances in immunized animals were significantly decreased (from 1.5 to 2.6 times), as compared to nonimmunized animals. The possible mechanisms of reducing the quantity of cytogenetic disorders in myelokaryocytes of immunized rats are discussed in this paper. The results obtained may be both of scientific and practical significance.
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D001853:Bone Marrow / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology; D002869:Chromosome Aberrations; D005260:Female; D005604:Francisella tularensis / Q000276:immunology*; D007114:Immunization; D008297:Male; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001428:Bacterial Vaccines; D002273:Carcinogens; D009153:Mutagens
Vliianie tuliaremiĭnoĭ zhivoĭ vaktsiny na khimicheskiĭ mutagenez u belykh krys.