[Liver damage caused by pesticides].
Histological liver findings are presented in 22 subjects with long-term exposure to pesticides who had been employed in agriculture. In addition to indicative liver cell changes (lipofuscinosis) and adaptive reactions (hypertrophy of the endoplasmic reticulum), lesions of the hepatocytes usually reflective of primary toxic reactions (single cell necroses, toxic cell swelling, fatty infiltration of the parenchyma) were observed. These occurred in part in combination with an activation of the mesenchyma. Considering the limited number of possible pathologic liver changes and the great variety of pesticides used, neither the individual findings nor their combinations could be considered characteristic of pesticide damage. A more precise evaluation of the results will only be possible in connection with a thorough analysis of working and environmental conditions and clinical and laboratory findings. The exclusion of additional exogenous and/or endogenous hepatotoxic factors is essential.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000009:adverse effects*
D010575:Pesticides
Leberschäden nach Pestizideinwirkung.