Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients.
Concentrations of isoxicam in the plasma and synovial fluid of 7 patients were investigated by means of high-pressure liquid chromatography. The samples were collected after 7 days' treatment with a single 200 mg isoxicam capsule taken each morning. A highly significant correlation was found (r = 0.82; p less than 0.05) between isoxicam concentrations in the plasma and in the synovial fluid. The mean concentration (+/- s.d.) was 25.54 +/- 10.91 micrograms/ml in the plasma and 17.47 +/- 6.54 micrograms/ml in the synovial fluid; the ratio between isoxicam concentrations in the synovial fluid and in the plasma was 71.06% +/- 18.83.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008592:Menisci, Tibial / Q000601:surgery; D010894:Piroxicam / Q000031:analogs & derivatives*; D013582:Synovial Fluid / Q000378:metabolism*; D013843:Thiazines / Q000097:blood / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; C013580:isoxicam