Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution.
The degradation of doxorubicin in acidic medium has been investigated using a stability indicating high pressure liquid chromatographic assay. Influences of temperature, pH and ionic strength on the degradation rate are quantified. The stability of doxorubicin at 50 degrees C is compared with those of seven related anthracyclines. The aglycone degradation products are characterized by mass spectrometry and by chromatography.
D000903:Antibiotics, Antineoplastic / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000032:analysis*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013058:Mass Spectrometry; D009279:Naphthacenes / Q000032:analysis; D009994:Osmolar Concentration; D012996:Solutions; D013696:Temperature
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D012996:Solutions; D004317:Doxorubicin