Concentration of D-propranolol in cervico-vaginal mucus: targeting of a novel spermicide.
It may be possible to develop new contraceptives that can be administered by mouth and will exert their effects after concentration in cervico-vaginal mucus. D-Propranolol was administered in 80 mg doses by mouth to six healthy female volunteers. Samples of blood plasma and cervico-vaginal mucus were obtained before and on six occasions up to 24 hours after drug ingestion. D-Propranolol was concentrated in cervico-vaginal mucus. No changes in blood pressure, pulse, or forced expiratory peak flow (FEPF) were observed.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002582:Cervix Mucus / Q000032:analysis*; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D011433:Propranolol / Q000008:administration & dosage / Q000032:analysis*; D011674:Pulse / Q000187:drug effects; D013089:Spermatocidal Agents / Q000008:administration & dosage / Q000032:analysis*; D014621:Vagina
D013089:Spermatocidal Agents; D011433:Propranolol