Phagocytic activity in mouse embryonic liver and spleen following hemolysis.
Phenylhydrazine (PHZ) was injected into pregnant mice and the number of phagocytizing cells was counted in the embryonic livers and spleens at 11th to 14th gestational days. A marked increase in the number of phagocytizing cells was observed in the embryonic spleen, whereas in the embryonic liver it was only slightly enhanced. This observation indicates that the response to hemolytic events is similar in embryonic and adult mammals.
D000818:Animals; D004622:Embryo, Mammalian; D004920:Erythropoiesis / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D008099:Liver / Q000196:embryology / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D010587:Phagocytosis; D010659:Phenylhydrazines / Q000494:pharmacology; D013154:Spleen / Q000276:immunology* / Q000648:ultrastructure
D010659:Phenylhydrazines; C030299:phenylhydrazine