Acute nonlymphoblastic leukemia with bone marrow eosinophilia and structural anomaly of chromosome 16.
A patient with acute myelocytic leukemia in relapse presented with t(16;21) (p12;q22). Hematologic studies revealed a large number of abnormal eosinophils in the bone marrow. The complexity of chromosome #16 rearrangements associated with acute nonlymphocytic leukemia and the possible significance of chromosomes #16 and #21 in relation to the concomitant eosinophilia are briefly discussed.
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002902:Chromosomes, Human, 16-18; D002904:Chromosomes, Human, 21-22 and Y; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic