Genetic differences between two substrains of NZB mice.
We have compared the NZB/B1NJ (/NJ) and NZB/B1Pt (/Pt) mouse substrains with respect to a number of immunological and biochemical polymorphisms. In agreement with earlier findings by other workers, we detected histocompatibility antigen difference(s) between the two substrains. Serological analysis indicated that /NJ and /Pt expressed the same allotypes of H-2, Thy-1 and Lyt-1 antigens, while they differed for the Lyt-2 antigen. Amongst 15 biochemical polymorphisms, which we assayed, /NJ and /Pt differed for four, namely Pep-3, Mup-1, Gpd-1 and Hbb. In addition, the two NZB substrains differed for the Hc marker (haemolytic complement).
D000818:Animals; D005819:Genetic Markers; D006084:Graft Rejection; D007519:Isoantigens / Q000235:genetics; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D009368:Neoplasm Transplantation; D011110:Polymorphism, Genetic; D013045:Species Specificity; D014185:Transplantation, Isogeneic
D005819:Genetic Markers; D007519:Isoantigens