Successful treatment of gram-negative bacillary meningitis with imipenem/cilastatin.
A patient with meningitis caused by a strain of Actinetobacter anitratus that was resistant to all commercially available antibiotics was treated with imipenem/cilastatin administered intravenously in a dose of 1 gm of imipenem every six hours. The minimal inhibitory concentration of imipenem against the isolate was less than or equal to 0.04 micrograms/ml. The patient tolerated the drug well and was cured after 12 days of therapy.
D000151:Acinetobacter Infections / Q000188:drug therapy*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015377:Cilastatin; D003521:Cyclopropanes / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D015378:Imipenem; D007263:Infusions, Parenteral; D008297:Male; D008581:Meningitis / Q000188:drug therapy* / Q000209:etiology; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000008:administration & dosage / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D003521:Cyclopropanes; D004338:Drug Combinations; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem