Circadian rhythms of adenosine deaminase activity in human erythrocytes: a transverse study on young, elderly and senile demented subjects.
Adenosine deaminase activity (ADA) was determined around the clock in human plasma from different groups of subjects: presumably clinically healthy women in Minneapolis, USA; healthy medical students, healthy elderly men and women, and mentally ill patients in Paris, France. In addition to analyses of variance, circadian characteristics were estimated individually and summarized by population-mean cosinor for each group. Technical and sampling considerations are documented: the individualized assessment of a circadian rhythm in adenosine deaminase is feasible in 8 out of 11 series from clinically healthy women covering 24h at 20-min intervals. A circadian population rhythm could be determined for the elderly men and women (p less than 0.05) and tentatively (p = 0.053) for the senile demented patients. A difference in circadian group rhythm characteristics found between the healthy elderly subjects and patients with senile dementia deserves further exploration.
D000243:Adenosine Deaminase / Q000097:blood*; D000305:Adrenal Cortex Hormones / Q000097:blood; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002940:Circadian Rhythm; D003704:Dementia / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009700:Nucleoside Deaminases / Q000097:blood*; D011388:Prolactin / Q000097:blood; D012621:Seasons; D012737:Sex Factors
D000305:Adrenal Cortex Hormones; D011388:Prolactin; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D006854:Hydrocortisone