[Effect of proglumide on gastrointestinal motility and gastric secretion in the conscious state].
Proglumide suppressed neither phase III activity nor propagation of interdigestive migrating contractions (IMC) in the gastrointestinal tract. Furthermore, proglumide did not inhibit the gastric motor activity stimulated by pentagastrin, however, it suppressed the pH in Pavlov pouch stimulated by pentagastrin in the interdigestive state. On the contrary, in the digestive state, proglumide did not suppress the pH. That might be due to not only various gut hormones including gastrin, but also neural stimulation, mechanical stimulation and so on. In conclusion, antigastrin effect of proglumide is rather remarkable on the acid secretion not on the gastrointestinal motor activity. Proglumide may be an antacid without suppression of motor activity.
D000818:Animals; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005973:Glutamine / Q000031:analogs & derivatives*; D009119:Muscle Contraction / Q000187:drug effects; D010418:Pentagastrin / Q000494:pharmacology; D011377:Proglumide / Q000494:pharmacology*
D005973:Glutamine; D010418:Pentagastrin; D011377:Proglumide