Effects of pharmacological doses of synthetic salmon calcitonin on wound healing in rats.
The effect of pharmacological doses of synthetic salmon calcitonin (CT) on the healing of experimental wounds in rats is studied. Subcutaneous administration of 20 IU/Kg body weight/day induces a significant increase in collagen content in the scars of treated animals at five, eight, ten and 15 days, as compared with the scars of non-treated animals. The scars of the treated animals also showed a greater tensile strength (TS) than those of the control group, except on day 8.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002921:Cicatrix / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
C028815:salmon calcitonin; D002116:Calcitonin; D003094:Collagen; D006909:Hydroxyproline