Preleukemia and urticaria pigmentosa followed by acute myelomonoblastic leukemia.
A preleukemic syndrome, mast cell hyperplasia in the bone marrow, and urticaria pigmentosa simultaneously developed in a 76-year-old woman. A year later, the patient died of acute myelomonoblastic leukemia. These associations provide evidence favoring the origin of the tissue mast cell from a bone marrow stem cell.
D000368:Aged; D001856:Bone Marrow Examination; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis / Q000473:pathology*; D011289:Preleukemia / Q000175:diagnosis / Q000473:pathology*; D014582:Urticaria Pigmentosa / Q000175:diagnosis / Q000473:pathology*