In vivo immunization against autologous glioblastoma-associated antigens.
A glioblastoma patient was immunized in vivo with a mixture of autologous and homologous glioblastoma cells coupled to adjuvant peptide and cord-factor analog. Immune activity of peripheral blood lymphocytes was measured in a short-term 51chromium-release assay against autologous tumor target cells. The patient developed direct cell-mediated cytotoxicity against tumor-associated antigens, which appeared to be T-cell mediated.
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm / Q000276:immunology; D003429:Cross Reactions; D003602:Cytotoxicity, Immunologic; D005910:Glioma / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm