Marker chromosomes in direct preparations of human large bowel tumors.
A survey of 257 marker chromosomes in 48 primary human large bowel adenocarcinomas showed that 44% were markers with recognized patterns. Chromosomes #1, #3, #5, #8, #9, #13, and #17 were involved most frequently. Markers related to chromosomes #7 and X were not seen in any recognizable form. The unidentified chromosomes were classified as markers with abnormal banding regions. In correlating tumor location and stage of invasion with markers, there were fewer markers in tumors from the right side. However, there was little difference in the number of markers seen in the left-sided tumors, irrespective of histopathologic stage, suggesting that function and microenvironmental conditions between various parts of the colon may be related to these differences. The most striking observation is that 21% of all tumors analyzed were without any obvious markers.
D000230:Adenocarcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans
D005819:Genetic Markers