Redox status and pulmonary vascular reactivity.
Oxygen radicals are produced during oxidative metabolism in proportion to the tissue oxygen tension. The studies reported here have shown that oxygen radicals or the sulfhydryl oxidant, diamide, caused pulmonary vasodilatation in the isolated perfused rat lung. Could oxygen radicals play a role in the physiologic control of pulmonary vascular smooth muscle tone?
D000493:Allopurinol / Q000502:physiology; D000818:Animals; D008168:Lung / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D010100:Oxygen / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014664:Vasodilation; D019820:Xanthine; D014969:Xanthine Oxidase / Q000502:physiology; D014970:Xanthines / Q000502:physiology
D014970:Xanthines; D019820:Xanthine; D000493:Allopurinol; D014969:Xanthine Oxidase; D010100:Oxygen