Delayed effects of experimental maternal diabetes on plasma cholesterol level and vascular prostacyclin synthesis in the offspring.
The effect of streptozotocin-induced diabetes during pregnancy in rats on prostacyclin synthesis in aorta and heart of offsprings was investigated. Although the aortic and heart syntheses of 6-keto-PGF1 alpha in the offsprings of diabetic rats were not altered at birth, a significant rise in aorta and a decrease in the heart were evident at weaning. At weaning, offsprings of diabetic rats also show a significant rise in plasma cholesterol. These studies show that maternal diabetes might cause effects in the offspring which might become evident in later life.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D000833:Animals, Suckling / Q000502:physiology; D001011:Aorta / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D008431:Maternal-Fetal Exchange; D009206:Myocardium / Q000378:metabolism; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D015121:6-Ketoprostaglandin F1 alpha; D002784:Cholesterol