Identification of urinary metabolites of 2,4,6-trinitrotoluene in rats by liquid chromatography-mass spectometry.
Metabolites of 2,4,6-trinitrotoluene (TNT) were found in the urine of rats fed with TNT. The urine extracts were analysed by liquid chromatography-mass spectrometry (LC-MS). Metabolites found included TNT itself as well as 2-amino-4,6-dinitrotoluene, 4-amino-2,6-dinitrotoluene and 2,4-diamino-6-nitrotoluene, indicating that reduction processes are responsible for the formation of these metabolites.
D000814:Aniline Compounds / Q000652:urine; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D014052:Toluidines / Q000652:urine; D014303:Trinitrotoluene / Q000652:urine*
D000814:Aniline Compounds; D014052:Toluidines; D014303:Trinitrotoluene; C035208:2-amino-4,6-dinitrotoluene; C035207:4-amino-2,6-dinitrotoluene; C046358:2,4-diamino-6-nitrotoluene