Dermatofibrosarcoma protuberans: a clinicopathological and immunohistochemical study with a review of the literature.
Forty-one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, alpha 1-antichymotrypsin and S-100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans are discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000378:metabolism; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D000514:alpha 1-Antichymotrypsin
D009418:S100 Proteins; D000514:alpha 1-Antichymotrypsin; D009113:Muramidase; D002918:Chymotrypsin