Developmental changes in the activities of prostaglandin synthesizing enzymes in the digestive and immune systems of rat.
The developmental changes of prostaglandin (PG) synthesizing enzymes in the digestive system (stomach and small intestine) and the immune system (spleen and thymus) of rats were investigated. In all the digestive organs, the predominant PG produced from PGH2 changed at around 2 weeks after birth to another PG. Further, the predominant activities of PG synthesizing enzymes were different organ by organ in the digestive system. In the case of the immune system, only the activity of PGD2 synthesizing enzyme displayed a significant increase during development and the activities of other PG synthesizing enzymes remained insignificant throughout the development. These results suggest that PGs may play important roles during the development of each organ.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D015237:Dinoprost; D015232:Dinoprostone; D005333:Fetus / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000096:biosynthesis*; D011457:Prostaglandins D / Q000096:biosynthesis; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011463:Prostaglandins H / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology / Q000378:metabolism*; D013270:Stomach / Q000201:enzymology; D013950:Thymus Gland / Q000201:enzymology / Q000378:metabolism*
D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D011463:Prostaglandins H; D015237:Dinoprost; D015232:Dinoprostone; D015230:Prostaglandin D2