Surfactant-induced increases of permeability of rat oral mucosa to non-electrolytes in vivo.
The effect of non-ionic, cationic and anionic surfactants on non-electrolyte permeability of rat oral mucosa in vivo was tested. The surfactants caused an increase in mucosal permeability to oil-soluble compounds and small and large water-soluble compounds. The effect was concentration-dependent, and both the cationic and anionic surfactants were more potent than the non-ionic compounds. Surfactant-treated tissue showed widening of the stratum corneum due to separation of layers and loss of surface layers. Measurement of the permeability to sodium lauryl sulphate indicated that this anionic surfactant produced damage to the permeability barrier.
D000818:Animals; D002594:Cetylpyridinium / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009061:Mouth Mucosa / Q000187:drug effects* / Q000378:metabolism; D010539:Permeability; D011136:Polysorbates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*
D011136:Polysorbates; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D002594:Cetylpyridinium