Release of synenkephalin from neuronal terminals in vitro.
Synenkephalin, the amino-terminal 1-70 residues of proenkephalin is released intact from bovine globus pallidus following potassium-induced depolarization in vitro via a Ca++ dependent mechanism. The release of synenkephalin accompanies that of Met-enkephalin in a molar ratio of 1/4. In contrast to Met-enkephalin which is readily destroyed when released, synenkephalin is not destroyed.
D000818:Animals; D002118:Calcium / Q000502:physiology; D002417:Cattle; D004744:Enkephalin, Methionine / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism*; D066298:In Vitro Techniques; D011188:Potassium / Q000494:pharmacology; D011498:Protein Precursors / Q000378:metabolism*
D004745:Enkephalins; D011498:Protein Precursors; D004744:Enkephalin, Methionine; C036693:synenkephalin; D011188:Potassium; D002118:Calcium