Cell kinetics of growth cartilage of achondroplastic (cn) mice.
Mice homozygous for the recessive gene achondroplasia (cn) aged 16 and 17 days and some homozygotes aged 22-34 days have disruptions in the growth of the proximal tibial growth plate which are due solely to reduced hypertrophic cell height. A second class of homozygote, distinguishable at 22 days, has a greater disruption due to much reduced hypertrophic cell height, reduced labelling index and reduction of the number of cells in the effective proliferative zone.
D000130:Achondroplasia / Q000235:genetics / Q000473:pathology*; D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000473:pathology; D007700:Kinetics; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics