Atracurium and severe hepatic disease: a case report.
Atracurium is a new non-depolarising neuromuscular blocking agent, metabolized through Hofmann elimination. A case is presented in which a 45-year-old patient with severe liver disease showed a decreased response to atracurium. The possible causes of resistance to atracurium are discussed. We conclude that atracurium may be used in patients with severe hepatic disease.
D000768:Anesthesia, General; D001279:Atracurium; D002802:Cholinesterases / Q000097:blood; D004351:Drug Resistance; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism* / Q000494:pharmacology; D008100:Liver Abscess / Q000378:metabolism / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000378:metabolism* / Q000494:pharmacology
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D002802:Cholinesterases