Quality control of automated cellular analyses -- the fallibility of embalmed blood.
The use of preserved blood for quality control is well established. The treatment of such materials to extend their life can impart a property to those materials such that external contaminants to diluents used for subsequent analysis may not be detected by these materials and give a false sense of security in a quality control program. The effect of the contaminant on fresh cells is more of a problem. Most contaminants affect cell volume, particularly the red cells which have been studied in-depth. White cell differential screening by size analysis is similarly affected. The recognition of the different properties of fresh and preserved blood helps explain results.
D001772:Blood Cell Count / Q000379:methods*; D001793:Blood Preservation; D001800:Blood Specimen Collection; D004615:Embalming; D006801:Humans; D010968:Plasticizers; D011786:Quality Control
D010968:Plasticizers