DR antigens in systemic sclerosis: lack of clinical correlations.
The information available in the literature is controversial as to the association between HLA-DR and systemic sclerosis (SS). We studied 44 Caucasians with SS and found DR1 (P = 0.025; RR = 2.4) and DR5 (P = 0.05; RR = 3.8) to be increased whereas DR3 was not found to be increased when compared to local controls. The possible influence of a DR specificity in the clinical manifestations of SS was also investigated but not found.
D005787:Gene Frequency; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D012595:Scleroderma, Systemic / Q000235:genetics*; D044465:White People
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II