Multicentric giant lymph node hyperplasia, Kaposi's sarcoma, and lymphoma.
We studied two cases of a recently recognized systemic lymphoproliferative disease with morphological features of Castleman's disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi's sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005534:Foot Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007136:Immunoglobulins / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology*; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D009852:Omentum / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology
D007136:Immunoglobulins