Immediate and delayed effects of an enzyme-dependent mineralizing mouthrinse on dental plaque.
Twenty-two children aged 13 to 14 years rinsed for 3 X 1 min periods with a supersaturated calcium phosphate solution containing urea and monofluorophosphate. Plaque sampled one min after the last rinse showed a marked increase in water-extractable F and a smaller increase in Ca but no increase in water-extractable P. Water-insoluble forms of all three ions were elevated, however. The mean plaque pH was 8.28. Plaque sampled 24 hr after the last rinse showed significant increases in water-insoluble F and Ca only, and no increase in pH. The prompt pH rise and disappearance of water-soluble P suggest that, on exposure to the mineralizing solution, urea and monofluorophosphate are rapidly hydrolyzed by plaque enzymes to provide catabolites which cause the immediate precipitation of fluoridated calcium phosphate.
D000293:Adolescent; D002118:Calcium / Q000378:metabolism; D002122:Calcium Chloride / Q000378:metabolism; D003773:Dental Plaque / Q000201:enzymology / Q000378:metabolism*; D005459:Fluorides / Q000378:metabolism; D006801:Humans; D008903:Minerals / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D009067:Mouthwashes / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D013997:Time Factors; D014508:Urea / Q000378:metabolism
D008903:Minerals; D009067:Mouthwashes; D010710:Phosphates; C012980:fluorophosphate; D010758:Phosphorus; D014508:Urea; D002122:Calcium Chloride; D005459:Fluorides; C018279:sodium phosphate; D002118:Calcium