Cariogenicity of isomaltulose (palatinose), sucrose and mixture of these sugars in rats infected with Streptococcus mutans E-49.
Each of three groups of Wistar rats, 19-20 animals per group, was fed an experimental diet containing either (1) isomaltulose 56%, (2) sucrose 56%, or (3) a mixture of isomaltulose and sucrose (17.5% + 38.5%). The animals were infected with Streptococcus mutans E-49 and one half of the animals was kept on the diet for 8 weeks and the other half for 14 weeks. Only sulcal caries was found in the isomaltulose animals after 8 weeks and 14 weeks. the group fed sucrose had high numbers of carious bucco-lingual, proximal and sulcal surfaces. The group fed the mixture of sucrose and isomaltulose had fewer lesions than the sucrose group on bucco-lingual surfaces after the 8 week experiment (P less than 0.01) and fewer bucco-lingual and proximal surfaces (P less than 0.01) after the 14 week experiment.
D000818:Animals; D002326:Cariogenic Agents; D003731:Dental Caries / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004037:Diet, Cariogenic; D004187:Disaccharides / Q000009:adverse effects*; D005260:Female; D007534:Isomaltose / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D013295:Streptococcus mutans / Q000187:drug effects / Q000502:physiology*; D013395:Sucrose / Q000008:administration & dosage / Q000009:adverse effects*
D002326:Cariogenic Agents; D004187:Disaccharides; D013395:Sucrose; D007534:Isomaltose; C008189:isomaltulose