[Liposome phospholipid substitution and lung function in surfactant deprived rats].
In vivo activity of an artificial surfactant was studied in surfactant depleted rats. After tenfold alveolar lavage, PaO2, tidal volume, and compliance of the respiratory system fell to one third of initial value. Substitution of large unilamellar vesicles containing 90% Dipalmitoylphosphatidylcholine and 10% unsaturated phosphatidylglycerol largely restored oxygenation and lung mechanics in most animals. Complete normalization with weaning from the ventilator, however, was achieved neither with liposomes nor with natural surfactant concentrate.
D000818:Animals; D008081:Liposomes / Q000008:administration & dosage*; D008168:Lung / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D011663:Pulmonary Surfactants / Q000008:administration & dosage*; D051381:Rats; D012129:Respiratory Function Tests
D008081:Liposomes; D011663:Pulmonary Surfactants; D010100:Oxygen
Liposomale Phospholipid-Substitution und Lungenfunktion bei surfactant-deprivierten Ratten.