Inhibition of B16-BL6 melanoma growth in mice by methionine-enkephalin.
The antitumor effect of methionine-enkephalin [( Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-micrograms dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.
D000818:Animals; D004744:Enkephalin, Methionine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009270:Naloxone / Q000494:pharmacology; D009368:Neoplasm Transplantation
D009270:Naloxone; D004744:Enkephalin, Methionine