New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits.
Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in experimental pneumococcal meningitis. Cefotaxime penetrated only moderately into the cerebrospinal fluid of rabbits with meningitis, whereas cefpimizole, BMY 28142, and HR 810 all exhibited unusually good penetration. The bactericidal activity in infected cerebrospinal fluid was comparable for the four drugs.
D000818:Animals; D000077723:Cefepime; D002439:Cefotaxime / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D002511:Cephalosporins / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D008586:Meningitis, Pneumococcal / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects; D000097572:Cefpirome
D000077723:Cefepime; D002439:Cefotaxime; D002511:Cephalosporins; D000097572:Cefpirome; C038845:cefpimizole