Gastroduodenal ulceration in rabbits producing antibodies to prostaglandins.
The consistent occurrence of gastric and duodenal ulcers was observed in laboratory rabbits used for production of high-titer plasma antibody to 6-keto PGF1 alpha and PGE2. Perforations developed in 7 of 10 animals, usually just distal to the pyloroduodenal junction. The remaining rabbits showed gross and/or microscopic evidence of imperforate ulcers and erosions. These lesions appeared to be direct pathologic complications of an immune response directed against prostaglandins since animals immunized against met-enkephalin with similar methods had no ulcers.
D015121:6-Ketoprostaglandin F1 alpha / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D015232:Dinoprostone; D008297:Male; D010437:Peptic Ulcer / Q000276:immunology* / Q000473:pathology; D011453:Prostaglandins / Q000276:immunology*; D011458:Prostaglandins E / Q000276:immunology; D011817:Rabbits
D011453:Prostaglandins; D011458:Prostaglandins E; D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone