[Limitation of disorders of the contractile function of the nonischemic areas of the myocardium during infarct by using the delta-sleep peptide and its cyclic derivative].
The effect of pretreatment with delta-sleep peptide (DSP) and its cyclic analogue (cDSP) on right-atrial myocardial distensibility and contractility disturbances in left-ventricular infarction (according to Selye) was studied in Wistar rats. These peptides, administered in a 20 micrograms/kg dose, 1 hour before the induction of experimental infarction, significantly limited the infarct-related depression of atrial distensibility and contractility, and also reduced atrial resistance to hypoxia and excessive calcium. Since infarction-associated disorders of myocardial structure and function in non-ischemic regions of the heart are due to the emotional-painful stress that accompanies the infarction, it can be assumed that the protective effect of DSP and cDSP consists in limiting the stress-induced response.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D009842:Oligopeptides / Q000627:therapeutic use*; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009842:Oligopeptides; D010456:Peptides, Cyclic; D003701:Delta Sleep-Inducing Peptide; C040856:delta-sleep-inducing peptide, cyclo-Gly-
Ogranichenie narusheniĭ sokratitel'noĭ funktsii neishemizirovannykh otdelov miokarda pri infarkte s pomoshch'iu peptida del'ta-sna i ego tsiklicheskogo proizvodnogo.