The effect of vaginal administration of various doses of prostaglandin E2 gel on cervical ripening and induction of labor.
Eighty patients with a Bishop score of less than or equal to 4 were randomly administered vaginal triacetin gel containing placebo or prostaglandin E2 in 1, 2, and 3 mg doses. Twelve to sixteen hours later, those not in labor underwent oxytocin induction. Increasing doses of prostaglandin were effective in ripening the cervix, and the higher doses were associated with significant success in inducing labor.
D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects*; D015232:Dinoprostone; D004487:Edema / Q000139:chemically induced; D005260:Female; D005316:Fetal Distress / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007751:Labor, Induced; D009325:Nausea / Q000139:chemically induced; D007744:Obstetric Labor Complications / Q000139:chemically induced; D010120:Oxytocics; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000009:adverse effects; D014622:Vaginal Creams, Foams, and Jellies; D014839:Vomiting / Q000139:chemically induced; D014845:Vulvar Diseases / Q000139:chemically induced
D010120:Oxytocics; D011458:Prostaglandins E; D014622:Vaginal Creams, Foams, and Jellies; D015232:Dinoprostone