Disposition of ethanol in maternal venous blood and the amniotic fluid.
The disposition of ethanol and acetaldehyde in maternal venous blood and amniotic fluid was studied over a time course following ingestion of 0.3 g/kg of ethanol by six healthy pregnant women at 16- to 18-weeks gestation. A time lag occurred in appearance and elimination of ethanol in and from the amniotic fluid when compared with maternal venous blood. Acetaldehyde was present in the maternal venous blood of four subjects but was found in the amniotic fluid in only one subject. Data from this clinical trial can be used by nurses who counsel pregnant women.
D000079:Acetaldehyde / Q000032:analysis / Q000097:blood; D000328:Adult; D000428:Alcohol Drinking; D000653:Amniotic Fluid / Q000032:analysis / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy / Q000187:drug effects*; D012044:Regression Analysis; D013997:Time Factors; D014680:Veins
D000431:Ethanol; D000079:Acetaldehyde