A simulation model for studies of intestine cell dynamics.
A dynamic simulation model for the epithelial cell structures of the intestine has been developed. The model is based on hypotheses found in the literature. It is shown that basic cell dynamics can be reproduced by simulation experiments. The simulation program is designed so that model output comparable with experimental findings can be obtained. The use of a dynamic simulation model can be interpreted as a simulated experiment in vivo. The model therefore allows analysis of dynamic behaviour that cannot be performed by normal experimental work. This means that the model can be used as a tool for verification/falsification of hypotheses about dynamics in both normal and abnormal cell structures.
D000818:Animals; D002453:Cell Cycle; D003201:Computers; D004847:Epithelial Cells; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology; D007422:Intestines / Q000166:cytology*; D007700:Kinetics; D008954:Models, Biological; D012984:Software; D013234:Stem Cells / Q000166:cytology