[Liver enzyme function and humoral immunity in workers exposed to vinyl chloride].
The work aims at studying the enzyme function of the liver, as well as the humoral immunity of workers engaged in the production of vinyl chloride and polyvinylchloride with proved hepatotropic and Raynaud syndromes. About 191 workers /experimental group/ from the synthesis and polymerization of vinyl chloride and 2 control groups--34 persons from Varna and 54 from G. Traĭkov were examined. The following biochemical and immunological studies were performed: GOT, GPT, GGTP, alkaline phosphatase, IGG, circulating immune complexes, titer of the complement, cryoglobulins in the serum and identification of the sediments by immunoelectrophoresis. It was established that the immune system was included in the early phases of toxic effect. Disturbances in the enzyme function and humoral immunity were registered both in workers with hepatotropic and Raynaud syndromes.
D000917:Antibody Formation / Q000187:drug effects*; D000936:Antigen-Antibody Complex / Q000032:analysis; D002031:Bulgaria; D002617:Chemical Industry; D056486:Chemical and Drug Induced Liver Injury; D003165:Complement System Proteins / Q000032:analysis; D003450:Cryoglobulins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology / Q000276:immunology; D009784:Occupational Diseases / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology; D011143:Polyvinyl Chloride / Q000009:adverse effects; D011928:Raynaud Disease / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology; D014505:Urban Population; D014752:Vinyl Chloride / Q000009:adverse effects*; D014753:Vinyl Compounds / Q000009:adverse effects*
D000936:Antigen-Antibody Complex; D003450:Cryoglobulins; D007136:Immunoglobulins; D014753:Vinyl Compounds; D011143:Polyvinyl Chloride; D003165:Complement System Proteins; D014752:Vinyl Chloride
Izuchavane enzimnata funktsiia na cherniia drob i khumoralniia imunitet na rabotnitsi, eksponirani na vinilkhlorid.