Isolation from Cannabis sativa L. of cannflavin--a novel inhibitor of prostaglandin production.
The isolation from Cannabis sativa L. of an inhibitor of prostaglandin (PG) E2 production by cultured rheumatoid synovial cells is described. This agent, for which the name Cannflavin has been coined, is distinct from cannabinoids on the basis of isolation procedure, preliminary structural analysis and biological properties. The activity of Cannflavin has been compared with several established anti-inflammatory drugs and the major cannabinoids.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002186:Cannabinoids / Q000494:pharmacology; D002188:Cannabis / Q000032:analysis*; D015232:Dinoprostone; D047309:Flavones; D006801:Humans; D066298:In Vitro Techniques; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000302:isolation & purification*; D011458:Prostaglandins E / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D002186:Cannabinoids; D047309:Flavones; D010936:Plant Extracts; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; C045457:cannflavin; D015232:Dinoprostone