Effects of various dietary animal and vegetable proteins on serum and biliary lipids and on gallstone formation in the hamster.
The objective of this study was to determine the effects of various dietary animal (casein, bovine albumin and egg albumin) and vegetable (soy, cottonseed and peanut) proteins on serum and biliary constituents and gallstone formation in the hamster. Eighty-four hamsters (60 +/- 5 g) were assigned to either a control group (Purina rat chow) or to one of the 6 experimental groups. Experimental diets contained 20.0% protein. With the exception of hamsters fed egg albumin, gallstone incidence was greater among hamsters fed animal proteins. Hamsters fed egg albumin exhibited a lower concentration of total serum cholesterol and HDL-cholesterol than most of the other experimental groups. There were no significant differences between experimental groups for either HDL3-cholesterol concentration or VLDL-LDL-cholesterol concentration. Bile acid concentrations within the vegetable Protein-fed groups were significantly higher than within the animal protein-fed groups. Casein- and bovine albumin-fed hamsters showed a significantly higher percentage of biliary cholesterol in the bile fluid. As the percentage of biliary cholesterol increased, the percentage of bile acids was found to decrease.
D000818:Animals; D010367:Arachis; D001646:Bile / Q000032:analysis*; D002364:Caseins / Q000494:pharmacology; D002769:Cholelithiasis / Q000209:etiology*; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL; D003369:Cottonseed Oil / Q000494:pharmacology; D006224:Cricetinae; D004044:Dietary Proteins / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008647:Mesocricetus; D010047:Ovalbumin / Q000494:pharmacology; D010743:Phospholipids / Q000032:analysis; D010940:Plant Proteins / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013025:Glycine max
D002364:Caseins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D003369:Cottonseed Oil; D004044:Dietary Proteins; D008055:Lipids; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D010940:Plant Proteins; D012710:Serum Albumin, Bovine; D010047:Ovalbumin; D002784:Cholesterol