[IKO-GM-1 monoclonal antibodies in the diagnosis of acute nonlymphoblastic leukemias].
The paper deals with the analysis of the phenotype of blastic cells obtained from patients suffering various subtypes (FAB-classification) of acute nonlymphoblastic leukemia. The study used monoclonal IKO-GM-1 antibodies complementary to an antigen common to myeloid and macrophagal cells. Also, previously described monoclonal IKO-11, IKO-1, IKO-02 and IKO-10 antibodies were employed. Application of the above antibodies appeared to provide information necessary for differentiating between myeloblastic and monoblastic leukemia. Complex immunologic and cytochemical investigations are required for identifying leukemia subtypes.
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D001853:Bone Marrow / Q000276:immunology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009101:Multiple Myeloma / Q000276:immunology
D000911:Antibodies, Monoclonal
Monoklonal'nye antitela IKO-GM-1 v diagnostike ostrykh nelimfoblastnykh leĭkozov.