The preparation and characterisation of 111In-labelled 791T/36 monoclonal antibody for tumour immunoscintigraphy.
The anti-human tumour monoclonal antibody 791T/36 was conjugated to the cyclic dianhydride of DTPA and radio-labelled with 111In. The labelling method proved to be both simple and reliable and would be suitable for routine clinical use. Subsequent characterisation of this radio-pharmaceutical in vitro and in tumour-bearing hosts gave a strong indication as to its suitability for clinical tumour localisation studies.
D000818:Animals; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007204:Indium; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000000981:diagnostic imaging*; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000276:immunology; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D007204:Indium