Projections from the anterior ventral cochlear nucleus to the central nucleus of the inferior colliculus in young and aging C57BL/6 mice.
Projections from the anterior ventral cochlear nucleus (AVCN) to the central nucleus of the inferior colliculus (ICC) were studied in young and aging C57BL/6 mice. The latter animals demonstrate progressive loss of hearing. Wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was injected into the inferior colliculus and retrograde transport to the AVCN sections, quality of labelling, number of labelled neurons adjusted for injection size, or topographic organization of projections. Thus, despite progressing loss of auditory sensitivity, chronic profound hearing loss (oldest animals), and aging, projections from AVCN to ICC remain stable.
D000375:Aging; D000818:Animals; D001306:Auditory Pathways / Q000166:cytology* / Q000473:pathology; D003056:Cochlear Nerve / Q000166:cytology*; D003638:Deafness / Q000473:pathology*; D006735:Horseradish Peroxidase; D007245:Inferior Colliculi / Q000166:cytology*; D037102:Lectins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000033:anatomy & histology*; D014909:Wheat Germ Agglutinins
D037102:Lectins; D014909:Wheat Germ Agglutinins; D006735:Horseradish Peroxidase