Isotachophoresis as a useful tool for monitoring neurological complications of acute leukaemia in children.
Cerebrospinal fluid proteins from 42 children with acute lymphoblastic leukaemia were analysed by isotachophoresis. The isotachopherograms of cerebrospinal fluid taken from patients undergoing central nervous system prophylaxis with neurological complications showed an increase of several peaks (albumin, prealbumin, and an unidentified peak), and changes in the globulin zone, compared with those from patients who had completed central nervous system prophylaxis for at least six months. The most striking finding was that these alterations were not associated with any other biochemical changes in the cerebrospinal fluid, as assayed by routine analysis. Isotachophoresis may be useful in the monitoring of therapy in children affected with acute lymphoblastic leukaemia.
D001927:Brain Diseases / Q000134:cerebrospinal fluid* / Q000209:etiology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D004586:Electrophoresis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000134:cerebrospinal fluid* / Q000150:complications; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid*; D013056:Spectrophotometry, Ultraviolet
D002556:Cerebrospinal Fluid Proteins