Efficacy of ivermectin against Syphacia obvelata (Nematoda) in mice.
Ivermectin was evaluated against natural and artificial pinworm (Syphacia) infections in mice. Ivermectin given in the diet for 6 days at 0.0005% was 99% effective against both immature and adult worms. A diet level of 0.0004% reduced immature and mature pinworm by 99 and 75%, respectively but 0.0001% was inactive. One oral dose of 2.0 mg/kg was 100 and 97% effective against gravid females and immature worms, respectively. A dose of 1.0 mg/kg was 96 and 66% effective against the same parasitic stages. A similar effect was observed against adult male worms where 94 and 86% were removed by one oral dose of ivermectin at 2.0 and 1.0 mg/kg, respectively.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005260:Female; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010123:Oxyuriasis / Q000188:drug therapy*; D010124:Oxyuroidea / Q000187:drug effects
D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin