title: [Langerhans cells--their structure, function and pathological role].
abstract: Data on the structure and function of Langerhans' cells (LC) are presented. LC are defined as dendritic cells of the epidermis and mucous membrane epithelium having the mesenchymal origin and relating to the antigen-representing macrophages. Morphological, enzymatic and antigenic LC markers are characterized. The crucial role of LC in the development of the skin delayed type hypersensitivity is shown: contact hypersensitivity, specific inflammation, transplant rejection, neoplastic process.
mesh_terms: D000818:Animals; D003877:Dermatitis, Contact / Q000473:pathology; D004485:Eczema / Q000473:pathology; D000078404:Epidermal Cells; D004817:Epidermis / Q000648:ultrastructure; D006168:Guinea Pigs; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology* / Q000473:pathology / Q000502:physiology / Q000648:ultrastructure; D008854:Microscopy, Electron; D012871:Skin Diseases / Q000473:pathology*
vernacular_title: Kletki Langerhansa--struktura, funktsiia, rol'v patologii.