Changes in platelet immunoprotein levels during therapy in adult immune thrombocytopenia.
Very early falls in platelet associated IgG, IgM and C3d were demonstrated following therapy with high dose i.v. immunoglobulin and with fresh frozen plasma. This suggests that the changes in platelet immunoproteins may be a primary event and that interference with antibody binding is a possible early mode of action of i.v. IgG.
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D001792:Blood Platelets / Q000276:immunology*; D003176:Complement C3 / Q000032:analysis*; D015933:Complement C3d; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D013921:Thrombocytopenia / Q000276:immunology / Q000628:therapy*
D003176:Complement C3; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015933:Complement C3d