Well-differentiated lymphocytic lymphoma with peripheral blood involvement, osteolytic bone lesions, and hypercalcemia. A case report and review of the literature.
It is rare for small lymphocytic B-cell malignancies to be associated with osteolytic bone lesions and/or hypercalcemia. The authors present an unusual case of well-differentiated lymphocytic lymphoma (DWDL) in a 70-year-old man who had osteolytic bone lesions and subsequently developed severe refractory hypercalcemia. The possible etiologic mechanisms responsible for these findings are discussed, and a brief review of the literature is presented.
D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D001862:Bone Resorption / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D008223:Lymphoma / Q000097:blood / Q000473:pathology*; D008297:Male; D010014:Osteolysis / Q000473:pathology*; D013125:Spinal Neoplasms / Q000473:pathology