Influence of ultraviolet radiation treatment on the survival of heterotopic skin grafts in the mouse.
Isolated mouse tail skin was UV-irradiated in vitro at a dose of 40 mJ/cm2 from both sides to remove the Ia immunogenicity. Immediately after irradiation the skin was transplanted onto the flank of allogeneic mice. When there was a total H-2 difference between donor and recipient, the UV-irradiated skin did not show a prolonged survival compared to control grafts. In the case of an I-region difference only, i.e., B10.AQR grafts onto B10.T (6R) recipients, a significant prolongation of the survival time was observed, whereas 50% of the UV-treated grafts were not rejected at all.
D000818:Animals; D006085:Graft Survival / Q000528:radiation effects*; D006649:Histocompatibility Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D012867:Skin / Q000276:immunology / Q000528:radiation effects; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014466:Ultraviolet Rays
D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II