The effect of H-2IJ disparity on induction of allotransplantation tolerance by lentil lectin.
The effect of an H-2IJ disparity on skin graft survival was studied in 18 mouse donor-recipient strain combinations, in which the recipients were treated with an efficient immunosuppressant, lentil lectin (LCA). The simultaneous I-J disparity essentially had no (or a slightly adverse) effect on the graft survival times in strain combinations differing at the K and I-A loci or in the entire H-2 complex. In two strain combinations incompatible at the D locus, the simultaneous I-J disparity promoted graft survival. The disparity at the I-J locus therefore seems to have only a marginal effect on the survival of allografts in most of the LCA-treated recipients, but it may promote graft survival in some animals. A similar tolerance-promoting effect was also observed with D disparity.
D000818:Animals; D005260:Female; D006085:Graft Survival; D006183:H-2 Antigens / Q000235:genetics*; D037102:Lectins / Q000494:pharmacology; D051379:Mice; D037121:Plant Lectins; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D037102:Lectins; D037121:Plant Lectins; C033619:lentil lectin