title: Acute lymphoblastic leukemia in childhood.
abstract: This article reviews those factors that have been responsible for progress in the past, describes current biologic and therapeutic approaches to ALL, and discusses those unresolved treatment issues that pose the major challenge for the future.
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001855:Bone Marrow Diseases / Q000473:pathology; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007945:Leukemia, Lymphoid / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D009423:Nervous System Neoplasms / Q000473:pathology / Q000517:prevention & control; D011379:Prognosis; D012008:Recurrence; D012306:Risk; D013736:Testicular Neoplasms / Q000473:pathology; D014481:United States