[Immunogenicity of synthetic sex hormones and thrombogenesis].
The ingestion of synthetic steroidal and non-steroidal estrogens may induce antiestrogen antibodies in women on oral contraceptives, and in prostatic patients treated with diethylstilbestrol (DES). Natural sex hormones have no such effect. A radioimmunoassay with tritiated ethinylestradiol or DES was applied to study the prevalence of synthetic sex hormone antibodies in 2 populations: 100 women on estroprogestative hormones and 93 cases of DES treated prostatic cancers. Homologous non-treated controls were compared. Results allowed to identify among treated and asymptomatic subjects an immunoreactive population of 30% women and 47% men. Furthermore, the antibodies were found with a much higher frequency (p less than 0.001) in patients who had experienced a thromboembolic disease while on treatment: 90% of women and 74% of men. The importance of these antibodies as a risk factor, their possible role in promoting vascular lesions, the interest of their detection for the prevention of the vascular risk induced by synthetic sex hormones, are considered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects / Q000627:therapeutic use*; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000276:immunology; D013923:Thromboembolism / Q000209:etiology* / Q000276:immunology
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D045166:Estradiol Congeners; D004997:Ethinyl Estradiol; D004054:Diethylstilbestrol
Immunogénicité des hormones sexuelles synthétiques et thrombogenèse.