title: Antibiotic susceptibility of clinical isolates of clostridia.
abstract: Over a 2 1/2 year period 361 clinical isolates of clostridia, representing 28 species, were tested for susceptibility to commonly used antimicrobial agents. Penicillin resistant strains were tested for their ability to produce beta-lactamase: of the commonly isolated species only Clostridium beijerinckii/butyricum produced the enzyme. Cl. perfringens exhibited a low incidence of resistance to all of the agents tested. Cl. difficile showed a high degree of resistance to penicillin and clindamycin, whilst all strains were sensitive to vancomycin. Chloramphenicol and amoxycillin/clavulanic acid were found to be highly active against most clostridia; metronidazole was the only agent to which no resistance was demonstrable.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects* / Q000201:enzymology; D003015:Clostridium Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D001618:beta-Lactamases