Inhibitory activity of cefpiramide on beta-lactamase.
The beta-lactamase stability and inhibitory activity of cefpiramide were investigated. Cefpiramide was found to be stable to hydrolysis and inhibited beta-lactamase produced by Citrobacter freundii, Enterobacter cloacae, Morganella morganii, and Escherichia coli. Kinetic studies showed that cefpiramide is a competitive inhibitor of cephaloridine hydrolysis by E. cloacae beta-lactamase.
D002439:Cefotaxime / Q000378:metabolism; D002509:Cephaloridine / Q000378:metabolism; D002511:Cephalosporins / Q000494:pharmacology*; D002954:Citrobacter / Q000201:enzymology; D004357:Drug Synergism; D004754:Enterobacter / Q000201:enzymology; D004926:Escherichia coli / Q000201:enzymology; D006868:Hydrolysis; D011511:Proteus / Q000201:enzymology; D065093:beta-Lactamase Inhibitors
D002511:Cephalosporins; D065093:beta-Lactamase Inhibitors; D002509:Cephaloridine; D002439:Cefotaxime; C036666:cefpiramide