Studies with temocillin in a hamster model of antibiotic-associated colitis.
Hamsters given the new penicillin temocillin, either orally or by injection, did not develop antibiotic-associated colitis, whereas animals given the control antibiotics cefoxitin or clindamycin developed the disease, which is characterized by marked hemorrhagic cecitis and high cecal levels of Clostridium difficile cytotoxin.
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002440:Cefoxitin / Q000633:toxicity; D002981:Clindamycin / Q000633:toxicity; D003013:Clostridium / Q000302:isolation & purification; D003092:Colitis / Q000139:chemically induced*; D006224:Cricetinae; D005243:Feces / Q000382:microbiology; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D007279:Injections, Subcutaneous; D008647:Mesocricetus; D010406:Penicillins / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D010406:Penicillins; C031367:temocillin; D002981:Clindamycin; D002440:Cefoxitin