Chromosome mapping of cell membrane antigens expressed on activated B cells.
Hybrids formed by fusion of either human acute lymphoblastic or chronic lymphocytic leukemia cells and the mouse myeloma P3.X63.Ag8/653 have been used to show that the expression of two cell surface antigens, Bp37 and p76, associated with B cell activation and detected by the monoclonal antibodies BB1 and BB2, respectively, segregate with human chromosomes 12 and 19, respectively. Another antigen expressed on activated B cells (p24) also maps to chromosome 12 (Katz et al., Eur. J. Immunol. 1984. 13: 1008) which is of interest in the light of the frequent involvement of this chromosome in certain B cell leukemias and lymphomas.
D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics*; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D002460:Cell Line; D002874:Chromosome Mapping; D005796:Genes; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007527:Isoenzymes / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D010215:Papio
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007527:Isoenzymes