[Stimulating action of cadmium on the Na-dependent transport of organic acid in the frog kidney].
Cadmium ions (10(-5)-10(-3) M) stimulate Na-dependent transport of a weak organic acid, fluorescein, into the proximal tubules of surviving frog kidney. Their stimulatory action ceases with increasing the duration of incubation to 45-60 minutes (stimulation does not disappear after introducing acetate into the incubating medium), in the presence of amiloride in the tubular lumen or in the absence of Na+ from the medium. The data obtained in the present work coincide with the previously reported evidence of the influence of Cd2+ on the Na-independent fluorescein transport into the proximal tubules of rat kidney. They are in good accordance with the suggestion that the effect of Cd2+ of the weak organic acid transport is mediated through an acceleration of the active reabsorption of Na+ with the accompanying activation of Na,K-ATPase.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002104:Cadmium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005452:Fluoresceins / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011896:Rana temporaria; D012964:Sodium / Q000378:metabolism*; D013268:Stimulation, Chemical; D013997:Time Factors
D005452:Fluoresceins; D002104:Cadmium; D012964:Sodium
Stimuliruiushchee deĭstvie kadmiia na Na-zavisimyĭ transport organicheskoĭ kisloty v pochke liagushki.