Intracisternal bombesin induced inhibition of gastric secretion is not mediated through prostaglandin or opioid pathways.
Neuromedin B, a mammalian decapeptide which shares homology with the carboxyl terminal fragment of ranatensin R and bombesin, injected intracisternally (880 pmol) did not modify gastric acid secretion stimulated either by pylorus ligation in conscious rats or by pentagastrin infusion in urethane-anesthetized rats. Intracisternal bombesin (300 pmol) further enhanced PGE2-induced inhibition of gastric acid secretion and suppressed prostaglandin-induced stimulation of gastric secretory volume. Gastric response to intracisternal bombesin was not modified by indomethacin (10 mg/kg) or naloxone pretreatment (5 mg/kg). These results suggest that prostaglandin and opiate pathways are not mediating the inhibitory effect of intracisternal bombesin on gastric secretion and that neuromedin B does not mimic the central action of bombesin to inhibit gastric acid secretion.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D015232:Dinoprostone; D004723:Endorphins / Q000502:physiology; D005750:Gastric Juice / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D015287:Neurokinin B / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats
D004723:Endorphins; D009842:Oligopeptides; D011453:Prostaglandins; D011458:Prostaglandins E; D009270:Naloxone; D015287:Neurokinin B; C038393:neuromedin B; D015232:Dinoprostone; D001839:Bombesin; D007213:Indomethacin