Primary lymphoma of the central nervous system diagnosed by computed tomographic scan-directed needle biopsy with a frozen section immunoperoxidase technique.
Primary lymphoma of the central nervous system is an uncommon neoplasm that requires definitive diagnosis because it is potentially treatable. We report a case in which the diagnosis of lymphoma was unsuspected and was made by needle biopsy with computed tomographic scan direction. A frozen section immunoperoxidase technique demonstrated monoclonality. When combined with a compatible morphological appearance, this confirmed the diagnosis of lymphoma. This case demonstrates the importance of this immunochemical method in the rapid diagnosis of central nervous system lymphomas.
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology; D001707:Biopsy, Needle; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed