Characterization of stimulator cells for alloreactive cytotoxic-T-lymphocyte responses in vivo.
Mouse spleen cells were fractionated and tested for their ability to induce alloreactive cytotoxic-T-lymphocyte responses in vivo. The cells with allostimulatory potential are enriched maximally in a population of low density, Ig-negative, Thy 1-negative cells. This fraction has the cytochemical and ultrastructural characteristics of cells of the early myeloid series and not those of typical dendritic cells or macrophages. These myeloid cells represent a new subset of accessory cells which could be a potential source of allostimulation in organ grafts. They should be considered along with other accessory cell types as potential elements which induce transplantation responses.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D000938:Antigen-Presenting Cells / Q000145:classification / Q000502:physiology* / Q000648:ultrastructure; D003601:Cytotoxicity Tests, Immunologic; D004950:Esterases / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010544:Peroxidases / Q000032:analysis; D013154:Spleen / Q000166:cytology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D007074:Immunoglobulin G; D010544:Peroxidases; D004950:Esterases; D000135:Acid Phosphatase