The failure of cyclosporin to inhibit granulomatous inflammation in acute Arthus-like panophthalmitis.
Acute Arthus-like panophthalmitis (AP) was induced in Lewis rat eyes by lens injury after immunization with whole rabbit lens extract. AP consists of an acute anterior ocular inflammation, followed by a posterior choroidal granulomatous reaction. Neither inflammatory response was inhibited by daily treatment with cyclosporin, 10 mg/kg, beginning on the day of lens injury. Cyclosporin would not be expected to interfere with the lens-induced anterior Arthus-like inflammation. The lack of inhibition of the choroidal inflammation was unexpected. The results are interpreted to indicate that the posterior granulomatous choroidal inflammation is a non-immune reaction initiated by the severe lens-induced Arthus-like reaction.
D000818:Animals; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000517:prevention & control; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000517:prevention & control; D010202:Panophthalmitis / Q000276:immunology* / Q000517:prevention & control; D051381:Rats; D011917:Rats, Inbred Lew
D003524:Cyclosporins