title: Psoriasis: a disease of the total skin.
abstract: Psoriasis is a disease of the total skin, which becomes clinically evident when a psoriatic lesion appears following an injury to the symptomless skin of a psoriasis patient. Although not all biopsy specimens of the symptomless skin show pathologic findings, the evolution of a psoriatic plaque can be envisioned as developing from the nonvisible phases of residual psoriasis, prepsoriasis, and latent psoriasis into a visible state where macules evolve into papules and papules coalesce to form plaques.
mesh_terms: D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011565:Psoriasis / Q000473:pathology*