title: Effects of bovine viral diarrhea virus on the percentages and absolute numbers of circulating B and T lymphocytes in cattle.
abstract: The percentage and absolute numbers of circulating B and T lymphocytes were determined for 10 healthy cattle by labeling mononuclear cells with anti-bovine immunoglobulin or peanut agglutinin. The cattle were then inoculated with a cytopathogenic isolate of bovine viral diarrhea (BVD) virus, and B- and T-lymphocyte populations were again quantitated at given intervals. Seemingly, BVD virus caused a decrease in the absolute numbers of B and T lymphocytes and in the percentage of T lymphocytes. Although these effects lasted through 7 days, all of the cattle recovered from infection and had detectable BVD virus-neutralizing antibodies in their sera 17 days after exposure.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D007140:Immunoglobulin Fab Fragments; D037102:Lectins; D007958:Leukocyte Count / Q000662:veterinary; D008856:Microscopy, Fluorescence; D008858:Microscopy, Phase-Contrast; D019887:Peanut Agglutinin; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D007140:Immunoglobulin Fab Fragments; D037102:Lectins; D019887:Peanut Agglutinin