Production of colony-stimulating activity (CSA) by T-chronic lymphocytic leukemia cells.
T-lymphocytes are probably involved in regulating myelopoiesis. We show that homogeneous populations of leukemic T-lymphocytes freshly obtained from two patients with T cell chronic lymphocytic leukemia produce colony-stimulating activity. The cells from both patients showed the antigenic and biochemical phenotype of the mature T-lymphocyte of the helper subset. This adds further support to the view that helper T-lymphocytes may regulate hematopoiesis in addition to their role in the immune function.
D000243:Adenosine Deaminase / Q000378:metabolism; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000378:metabolism* / Q000648:ultrastructure
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D003115:Colony-Stimulating Factors; D007136:Immunoglobulins; D004253:DNA Nucleotidylexotransferase; D000243:Adenosine Deaminase