Pentamidine treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Association with acute renal failure and myoglobinuria.
A 31-year-old man with acquired immunodeficiency syndrome and biopsy-proved Pneumocystis carinii pneumonia developed acute renal failure, elevated creatinine kinase levels, and myoglobin in both serum and urine while being treated with pentamidine. The patient was receiving no other nephrotoxic medications at the time, and these unusual complications were directly related to the pentamidine.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000578:Amidines / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009212:Myoglobinuria / Q000139:chemically induced*; D010419:Pentamidine / Q000009:adverse effects*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy* / Q000209:etiology; D012206:Rhabdomyolysis / Q000139:chemically induced*
D000578:Amidines; D010419:Pentamidine