title: Thyroxine binding and TSH in recurrent depressive episodes.
abstract: Evidence of a link between recurrent affective disorders and the hypothalamic-pituitary-thyroid (HPT) axis has been frequently reported. The clinical course of 40 recurrent major depressive patients was monitored over 2 years with respect to several parameters of thyroid function. Patients entering a depressive recurrence manifested lower free versus bound thyroxine quotients and had higher TSH secretion. A dynamic HPT axis response may enhance the clinical outcome of acute depression during continuation pharmacotherapy.
mesh_terms: D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008094:Lithium / Q000627:therapeutic use; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013972:Thyrotropin; D008094:Lithium; D013974:Thyroxine