Anti-A production by a group O spleen transplanted to a group A recipient.
A group A1 diabetic received a pancreas-spleen transplant from a group 0 donor. Severe immune hemolysis due to anti-A ensued, requiring graft splenectomy. The transplanted spleen can be a potent source of blood group antibody.
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000917:Antibody Formation; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D006461:Hemolysis; D006801:Humans; D008297:Male; D016035:Pancreas Transplantation; D013154:Spleen / Q000637:transplantation*; D014184:Transplantation, Homologous / Q000009:adverse effects*
D000017:ABO Blood-Group System