Physiology of B cells in mice with X-linked immunodeficiency. I. Size, migratory properties, and turnover of the B cell pool.
In terms of certain immune functions and density of surface IgM, B cells from xid mice are often viewed as the equivalent of the immature (Lyb-5-) B cell subset of normal adult mice. In this paper we examine xid B cells with regard to certain physiologic functions, including homing to the lymphoid tissues, recirculation, and turnover. Xid mice were found to possess about one-third of the total number of B cells found in normal mice. This applied irrespective of whether one examined the spleen, lymph nodes, or outputs of B cells in thoracic duct lymph. In terms of migration to spleen, lymph nodes, and Peyer's patches, capacity to recirculate from blood to thoracic duct lymph, and turnover, xid B cells proved to be indistinguishable from normal spleen or thoracic duct B cells. Within these parameters, most xid B cells closely resemble the normal mature long-lived population of B cells residing in the recirculating pool of normal mice. Because xid B cells are functionally quite different from normal mature B cells, it seems reasonable to view xid B cells as an abnormal population not represented in normal mice.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D002452:Cell Count; D002454:Cell Differentiation; D002465:Cell Movement; D005260:Female; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008196:Lymph / Q000166:cytology; D008198:Lymph Nodes / Q000166:cytology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology*; D008817:Mice, Mutant Strains / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013897:Thoracic Duct / Q000166:cytology; D014960:X Chromosome
D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell