Bone marrow transplantation in the management of childhood cancer.
Bone marrow transplantation has become a curative therapy for selected children with leukemia and offers promise as a treatment for certain childhood solid tumors. Complications such as graft-versus-host disease, interstitial pneumonia, and recurrent malignancy continue to affect many patients. As these are overcome, and as methods for T-cell depletion and marrow purging are developed that extend the scope of bone marrow transplantation, it will become an even more significant therapy for childhood malignancy.
D000206:Actuarial Analysis; D000208:Acute Disease; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation; D002469:Cell Separation / Q000379:methods; D002648:Child; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006238:Haploidy; D006650:Histocompatibility Testing; D006801:Humans; D007239:Infections / Q000209:etiology; D007938:Leukemia / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000628:therapy; D007951:Leukemia, Myeloid / Q000628:therapy; D008107:Liver Diseases / Q000209:etiology; D008212:Lymphocyte Depletion; D008223:Lymphoma / Q000628:therapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011183:Postoperative Complications / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000209:etiology; D012008:Recurrence; D014181:Transplantation Immunology