Effects of hypoglycemia on rat brain polyribosome sedimentation pattern.
Insulin-induced hypoglycemia provokes polyribosome disaggregation and accumulation of monomeric ribosomes in the brain of rats with hypoglycemic paresis and coma. The extent of brain polyribosome disaggregation depends on the decrease of blood glucose concentration, and in comatose animals on the duration of hypoglycemia. Cycloheximide prevents the disaggregation of brain polyribosomes induced by hypoglycemia, indicating that hypoglycemia affects brain protein synthesis, decreasing the rate of initiation relative to the rate of elongation of polypeptide chain synthesis.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D002499:Centrifugation, Density Gradient; D003513:Cycloheximide / Q000494:pharmacology; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D007331:Insulin Coma / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D011132:Polyribosomes / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012270:Ribosomes / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D009419:Nerve Tissue Proteins; D003513:Cycloheximide