Synthesis and antibacterial activity of 3-(2-arylvinylen)-2-isoxazolines.
3-[2-(5-Nitro-2-furyl)vinylen]-2-isoxazoline (VIII) and 3-nitro-, 3-amino- and 3-acylaminostyryl-2-isoxazolines have been synthesized and tested for antibacterial activity. Compound (VIII) showed potent antibacterial activity in vitro against several strains of S. aureus and E. coli (two to eight times more active than furazolidone). None of the styryl derivatives exhibited significant activity.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004926:Escherichia coli / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis*; D013211:Staphylococcus aureus / Q000187:drug effects; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007555:Isoxazoles; D010080:Oxazoles; D014753:Vinyl Compounds