Primary hypothyroidism and essential hypernatremia in a patient with histiocytosis X.
A 27 year old woman with histiocytosis X had an unusual initial presentation with features of primary hypothyroidism and a goitre. Diagnosis was made by lung and thyroid biopsies. Endocrine tests showed the presence of hypopituitarism and a discrete suprasellar mass, consistent with hypothalamic histiocytosis X, was demonstrated by computerised tomography. Radiotherapy and chemotherapy arrested the clinical progression of the disease.
D000328:Adult; D001706:Biopsy; D005260:Female; D006042:Goiter / Q000209:etiology / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006955:Hypernatremia / Q000209:etiology*; D007029:Hypothalamic Neoplasms / Q000150:complications / Q000000981:diagnostic imaging; D007037:Hypothyroidism / Q000209:etiology* / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology; D014057:Tomography, X-Ray Computed