The effect of steroid sulphatase on stratum corneum shedding in patients with X-linked ichthyosis.
After the application under occlusion of partially purified stratum corneum steroid sulphatase to the skin of patients with X-linked ichthyosis, the detachment ratio of stratum corneum fragments was significantly increased. There was no significant change in normal subjects or in patients with ichthyosis vulgaris.
D008040:Genetic Linkage; D006801:Humans; D007057:Ichthyosis / Q000201:enzymology / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000172:deficiency / Q000494:pharmacology*; D014960:X Chromosome
D013429:Sulfatases; D043266:Steryl-Sulfatase