[Interaction of the tumor and immunocompetent cells of lung cancer patients in diffusion chambers].
Peculiarities of interaction of tumour cells and lymphocytes were studied in cultivating explants of 19 human lung tumours in diffusion chambers. Results were analyzed with due regard for the histological structure of tumours, level of tissue differentiation and clinical stage of the disease. Criteria are developed for evaluating the interaction of tumour cells and lymphocytes, namely: the relative content of lymphocytes in culture, the number of spheroids and a way of their destruction (edge one or with lymphocytes), presence of lymphocytic clusters and aggregates of blast-like cells, presence of tumour cell-lymphocyte complexes. The obtained results may be used for estimation of the tumour malignancy degree.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D002277:Carcinoma / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D009367:Neoplasm Staging; D013601:T-Lymphocytes / Q000473:pathology*; D013997:Time Factors
Vzaimodeĭstvie opukholevykh i immunokompetentnykh kletok bol'nykh rakom legkogo v diffuzionnykh kamerakh.