Increased plasma levels of vasoactive intestinal polypeptide in pigs during endotoxinaemia.
Vasoactive intestinal polypeptide (VIP) is a highly potent vasodilatator. Cardiovascular changes and plasma VIP levels were studied during endotoxinaemia (Escherichia coli endotoxin 1 mg/kg) in a carefully monitored porcine model. Endotoxin infusion resulted in a profound but reversible shock and a substantial rise in plasma VIP levels. Increased levels of VIP could be demonstrated already after 30 min of endotoxin infusion and increased further during the infusion. Animals followed for a period of 60 h demonstrated slowly declining levels of VIP after endotoxin infusion but significantly elevated levels were usually found 24 h after infusion. Control animals did not show any changes in VIP during a similar procedure. Release of gastrointestinal peptides may be of importance during septic shock.
D000818:Animals; D002850:Chromatography, Gel; D004731:Endotoxins / Q000097:blood*; D004926:Escherichia coli; D005260:Female; D006439:Hemodynamics; D007958:Leukocyte Count; D008297:Male; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology; D013552:Swine; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D004731:Endotoxins; D014660:Vasoactive Intestinal Peptide