Treatment of advanced esthesioneuroblastoma with high-dose chemotherapy and autologous bone marrow transplantation. A case report.
A 46-year-old woman presented with an advanced unresectable esthesioneuroblastoma which failed to respond to radiation therapy and one course of chemotherapy. She underwent treatment with high-dose chemotherapy (cyclophosphamide, doxorubicin, and vinblastine) followed by autologous bone marrow transplantation. The major toxicity from the regimen was severe oropharyngeal mucositis. A complete remission was achieved and the patient is free of disease and asymptomatic 3.5 years after treatment.
D000971:Antineoplastic Combined Chemotherapy Protocols; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000188:drug therapy / Q000628:therapy*; D009669:Nose Neoplasms / Q000188:drug therapy / Q000628:therapy*; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage*
D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide