Long-term effect of hypophysectomy on various fractions of sulfhydryl groups in thyroid, adrenal and some other organs in rats.
The non-protein (NP-SH), total (T-SH) and protein bound sulfhydryl groups (PB-SH) were measured in the thyroid, adrenals, kidney, liver and skeletal muscle of hypophysectomized and sham operated adult male rats. After hypophysectomy, T-SH and PB-SH in the adrenals and thyroid decreased significantly (P less than 0.01). The maximal decline occurred at the intervals of 12-24 days after hypophysectomy. The NP-SH fraction, which is represented mainly by SH-glutathione, decreased within 24 h after hypophysectomy in both glands, then increased transiently and later it again decreased in parallel to the level of both T-SH and PB-SH. In the kidney, all fractions of SH groups increased at 4--8 days, then decreased markedly reaching control or even subcontrol levels. In contrast, we failed to observe hypophysectomy induced changes of any of the SH-fractions in the liver and muscle of rats.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D007016:Hypophysectomy; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*; D013997:Time Factors
D013438:Sulfhydryl Compounds; D005978:Glutathione