title: The concept of the single body pool of metabolic nitrogen in determining the rate of whole-body nitrogen turnover.
abstract: The concept of the single pool of metabolic nitrogen in measuring the rate of whole-body protein turnover has been examined both with the practical evidence which is available in the literature and from a theoretical point of view. It is concluded that for the most part the concept is not valid. The main problem is one of introducing the isotope uniformly throughout the body. It is suggested that better results may be obtained if the 15N tracer is given simultaneously by both the oral and intravenous route.
mesh_terms: D000284:Administration, Oral; D000641:Ammonia / Q000378:metabolism; D002648:Child; D005998:Glycine / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D007263:Infusions, Parenteral; D008433:Mathematics; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism*; D009587:Nitrogen Isotopes; D011506:Proteins / Q000378:metabolism; D014508:Urea / Q000096:biosynthesis
chemical_list: D009587:Nitrogen Isotopes; D011506:Proteins; D000641:Ammonia; D014508:Urea; D009584:Nitrogen; D005998:Glycine