[Acute myelomonocytic and monoblastic leukemia with polyradicular symptoms].
Meningeal leukaemia, developed in 4 female patients with M4 or M5 leukaemia during a period of haematological remission. Polyradicular symptoms and signs dominated neurologically, but 3 patients also exhibited cranial nerve palsies. The neurological findings showed no reversal following intrathecal chemotherapy with normalization of liquor cytology. Patchy demyelinization in the region of the anterior spinal roots and of the proximal segments of the affected cranial nerves were responsible for the neurological features. Peripherally located streaky demyelinization of the olfactory bulb and of the optic chiasm were not found to cause any neurological manifestations.
D000010:Abducens Nerve; D000328:Adult; D000616:Aminoglutethimide / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D001932:Brain Neoplasms / Q000517:prevention & control; D002543:Cerebral Hemorrhage / Q000209:etiology; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000187:drug effects; D003389:Cranial Nerve Diseases / Q000209:etiology; D003561:Cytarabine / Q000627:therapeutic use; D003613:Danazol / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000150:complications*; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008580:Meningism / Q000150:complications; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D013126:Spinal Nerve Roots; D013629:Tamoxifen / Q000627:therapeutic use
D003561:Cytarabine; D013629:Tamoxifen; D000616:Aminoglutethimide; D003613:Danazol; D008727:Methotrexate
Akute myelomonozytäre und Monoblastenleukämien mit polyradikulärer Symptomatik.