Coagulopathy and hemorrhage associated with cefoperazone therapy in a patient with renal failure.
We have reported life-threatening gastrointestinal hemorrhage with hypoprothrombinemia in a patient treated with cefoperazone for a urinary tract infection. The coagulation abnormality was rapidly corrected with administration of vitamin K and discontinuation of the antibiotic. This complication of cefoperazone therapy is not widely recognized and may be seen more frequently with increased use of the drug.
D000368:Aged; D002438:Cefoperazone / Q000009:adverse effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000209:etiology
D002438:Cefoperazone