title: [Use of electrocumulation of 5-fluorouracil in treating acute experimental pancreatitis].
abstract: The effect of electrocumulation of 5-fluorouracil with the aid of electric field of constant current was studied in rats with experimental acute pancreatitis. 5-Fluorouracil was injected intraperitoneally in a dose of 4.5 mg per 100 g bw. Serum alpha-amylase, trypsin, trypsin inhibitor, lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5-fluorouracil electro-cumulation. The levels of serum enzymes as well as the total proteolytic activity in the pancreatic tissue were far more decreased starting from the 3d-6th hour after induction of acute pancreatitis in rats treated by 5-fluorouracil with the aid of electric field of constant current as compared with other groups of rats.
mesh_terms: D000208:Acute Disease; D000818:Animals; D004599:Electric Stimulation Therapy / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D010179:Pancreas / Q000201:enzymology; D010195:Pancreatitis / Q000188:drug therapy* / Q000201:enzymology; D010447:Peptide Hydrolases / Q000097:blood; D051381:Rats; D013997:Time Factors
chemical_list: D010447:Peptide Hydrolases; D005472:Fluorouracil
vernacular_title: Ispol'zovanie élektrokumuliatsii 5-ftoruratsila pri lechenii ostrogo éksperimental'nogo pankreatita.