Effect of thiamylal and diazepam on release of myoglobin and creatine phosphokinase by succinylcholine chloride during halothane anesthesia.
The effects of thiamylal and diazepam on the release of myoglobin and creatine phosphokinase following the administration of succinylcholine chloride during halothane anesthesia were studied. Thirty patients receiving halothane anesthesia were divided into three groups. In Group I, 1.5-2 mg/kg of thiamylal were given intravenously as pretreatment before the injection of succinylcholine chloride. In Group II, 0.3 mg/kg of diazepam were given and, in Group III, only succinylcholine chloride was injected. A significant increase in the serum myoglobin and creatine phosphokinase levels was observed in all groups. However, the values in Group I were significantly lower than those in Groups II and III and a significant difference was not detected between Group II and III. Our results indicate that thiamylal has a considerable inhibitory effect on the release of myoglobin and creatine phosphokinase from the muscle following the administration of succinylcholine chloride.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D003402:Creatine Kinase / Q000097:blood*; D003975:Diazepam / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006221:Halothane; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D009469:Neuromuscular Junction / Q000187:drug effects; D013390:Succinylcholine / Q000494:pharmacology*; D013840:Thiamylal / Q000494:pharmacology*; D013997:Time Factors
D009211:Myoglobin; D013840:Thiamylal; D003402:Creatine Kinase; D013390:Succinylcholine; D003975:Diazepam; D006221:Halothane