A protective role of 13-cis retinoic acid in thymic lymphoma induction.
The aim of the study was to analyze the incidence of X-ray induced lymphomas in C57B1/10W mice kept on diet with varying retinoid content. The mice whose diet was supplemented with 13-cis retinoic acid (300 mg per kg of chow) developed less lymphomas than those kept on Vitamin A deficient diet as well as on a standard diet (15 mg per kg of chow). Mice subjected to Vitamin A deficient diet displayed a shortening of the latency period.
D000284:Administration, Oral; D000818:Animals; D005260:Female; D015474:Isotretinoin; D007953:Leukemia, Radiation-Induced / Q000517:prevention & control*; D008223:Lymphoma / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D013953:Thymus Neoplasms / Q000517:prevention & control*; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D014212:Tretinoin; D015474:Isotretinoin