T-lymphocyte subpopulations identified by monoclonal antibodies after human bone-marrow transplantation.
Peripheral T-lymphocyte reconstitution after bone-marrow transplantation, 12 allogeneic and 13 autologous, was studied by indirect immunofluorescence assay using mouse monoclonal antibodies. Abnormal counts were detected in the two major sub-populations of T-cells i.e. helper and T cytotoxic-suppressor lymphocytes, defined by monoclonal antibodies (alpha Leu 3a and B 9.2), and in DR antigen-positive T-cells. The pattern of T-lymphocytes replenishment was identical for both types of transplant, and was not affected by Graft Versus Host disease (GVHD).
D000911:Antibodies, Monoclonal; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000276:immunology; D006801:Humans; D011183:Postoperative Complications / Q000276:immunology; D011184:Postoperative Period; D013601:T-Lymphocytes / Q000145:classification*
D000911:Antibodies, Monoclonal