[Hyperthermic effect of a trypsin inhibitor in rats and rabbits].
The influence of intraventricular and intravenous administration of trypsin inhibitor (from soya-bean) on the body temperature was studied in experiments on unanesthetized rats and rabbits. It was established that the substance provoked a steady and prolonged hyperthermia in rats and rabbits, attenuated by pre-administration of sodium salicylate. Hyperthermia was accompanied by a significant decrease in the content of PGE2 in the hypothalamus. The results suggest than inhibition of certain trypsin-like serine proteases in thermoregulatory centres may be one of the factors responsible for the development of fever.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D015232:Dinoprostone; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D011458:Prostaglandins E / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012980:Sodium Salicylate / Q000494:pharmacology; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
D011458:Prostaglandins E; D014361:Trypsin Inhibitors; D015232:Dinoprostone; D012980:Sodium Salicylate
Gipertermicheskiĭ éffekt ingibitora tripsina u krys i krolikov.