Anomeric specificity of mannose phosphorylation by hexokinase.
In rat parotid or pancreatic islet homogenates incubated at 7 degrees C, hexokinase displayed a greater affinity for but a lower maximal velocity with the alpha-anomer, as distinct from beta-anomer, of D-mannose. The anomeric specificity of mammalian hexokinase was similar in the case of D-mannose and D-glucose, but represented a mirror image of that of yeast hexokinase.
D000818:Animals; D003080:Cold Temperature; D005947:Glucose / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism*; D007515:Islets of Langerhans / Q000201:enzymology; D007536:Isomerism; D007700:Kinetics; D008358:Mannose / Q000378:metabolism*; D008433:Mathematics; D010306:Parotid Gland / Q000201:enzymology; D010766:Phosphorylation; D051381:Rats; D013379:Substrate Specificity
D006593:Hexokinase; D005947:Glucose; D008358:Mannose