Manipulations of 5-HT activity and memory in the rat.
The activity of 5-HT was manipulated by means of the peripheral injection of 5-HT reuptake inhibitors, fenfluramine and fluoxetine. These drug treatments, at doses higher than 1 mg/kg, produced retrograde amnesia in a one-trial appetitive learning task in rats. A non-specific inhibitor of 5-HT reuptake, imipramine, did not produce this amnesic effect, nor did the combination of fenfluramine with the MAOI tranylcypromine, although it produced, as expected, the "serotonergic syndrome." Results for the metabolic precursor of 5-HT, 5-HTP, also administered peripherally, were inconsistent, with amnesic effects seen at 5 and 20 mg/kg but none at 10 mg/kg.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004347:Drug Interactions; D005277:Fenfluramine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014191:Tranylcypromine / Q000494:pharmacology
D012702:Serotonin Antagonists; D005473:Fluoxetine; D005277:Fenfluramine; D012701:Serotonin; D014191:Tranylcypromine; D008094:Lithium; D006916:5-Hydroxytryptophan; D007099:Imipramine