Impaired antigen presenting function of macrophages from aged mice.
Using antigen-induced proliferation assay the presence of macrophages was found to be essential for the development of the T cell response. Decreased ability of antigen presentation by macrophages from aged A/J mice was detected.
D000375:Aging; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D005260:Female; D007114:Immunization; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D013601:T-Lymphocytes / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000276:immunology
D010132:p-Azobenzenearsonate