Mutagenicity arising from near-ultraviolet irradiation of N-nitrosomorpholine.
When a mixture of N-nitrosomorpholine and S. typhimurium TA100 in saline was irradiated with near-ultraviolet light, mutagenesis of the bacteria took place. The same observation was made with S. typhimurium TA1535, E. coli WP2 uvrA, pKM101 and uvrA/pKM101. Several other nitrosamines showed ed the same, but weaker, effect. Evidence is presented to indicate that the mutagenicity arises from the cellular phosphate-mediated photochemical formation of direct-acting mutagen from the nitrosamine.
D004926:Escherichia coli / Q000235:genetics / Q000528:radiation effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000528:radiation effects*; D009602:Nitrosamines / Q000528:radiation effects / Q000633:toxicity*; D010777:Photochemistry; D012486:Salmonella typhimurium / Q000235:genetics / Q000528:radiation effects; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D014466:Ultraviolet Rays
D009153:Mutagens; D009602:Nitrosamines; D013438:Sulfhydryl Compounds; C002741:N-nitrosomorpholine