[Evaluation of therapeutic effectiveness of prednisolone in patients with chronic active hepatitis based on the morphometry of liver biopsy specimens].
In 42 patients with chronic active hepatitis (CAH), liver biopsies were subjected to histological study and morphometry before and after prednisolone treatment (21 patients comprising group I) and treatment with a complex of vitamins B1, B6, B12 and C (21 patients comprising group II). Combined study of liver biopsies during treatment makes it possible to evaluate objectively enough the results of prednisolone therapy of CAH patients. The authors confirmed the efficacy of prednisolone therapy of patients with sero-negative CAH. These patients demonstrated a reduction in dystrophic alterations, volume of inflammatory cells in the portal tracts and in the areas of necrosis, a lowering of the number of aggressive lymphocytes. Prednisolone was discovered to have an adverse effect on seropositive CAH, to activate virus replication in liver tissue, intensify necrotic alterations in the parenchyma and inflammatory reaction in the portal tracts.
D001205:Ascorbic Acid / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000188:drug therapy* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D014803:Vitamin B Complex / Q000627:therapeutic use
D014803:Vitamin B Complex; D011239:Prednisolone; D001205:Ascorbic Acid
Otsenka terapevticheskoĭ effektivnosti prednizolona u bol'nykh khronicheskim aktivnym gepatitom po dannym morfometrii bioptatov pecheni.