Histiocytosis X (Langerhans' cell granulomatosis) of the thymus. A clinicopathologic study of four childhood cases.
Four cases of histiocytosis X (Langerhans' cell granulomatosis) involving the thymus are presented. All the patients were children, their age at diagnosis ranging from 2 months to 8 years. In two cases, the disease seemed restricted to the thymus; in the other two, there was extrathymic involvement. The treatment was generally in the form of surgical excision. All the patients are alive and well on follow-up. The light-microscopic appearance was that classically described for histiocytosis X in all cases. Staining for S-100 protein was strongly positive in the two cases in which it was carried out.
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004803:Eosinophilic Granuloma / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007801:Langerhans Cells / Q000473:pathology*; D008297:Male; D009418:S100 Proteins / Q000032:analysis; D013953:Thymus Neoplasms / Q000473:pathology* / Q000601:surgery; D013997:Time Factors
D009418:S100 Proteins