title: The prezygotic origin of structural mosaicisms.
abstract: A theoretical model to explain the occurrence of some structural mosaicisms is proposed. It is based on a prezygotic (meiotic) half chromatid mutation leading, after the first post-zygotic DNA replication, to a structural mosaic.
mesh_terms: D000818:Animals; D002842:Chromatids / Q000502:physiology; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D008540:Meiosis; D008957:Models, Genetic; D009030:Mosaicism; D009154:Mutation