Indoramin-prolongation of repolarization time, a mechanism of bradycardia in man?
The effect of indoramin, a selective alpha 1-adrenoceptor antagonist, on ECG time intervals in normal man was studied. Significant prolongation of QTc was observed after indoramin 100 mg, with no change in QRS duration. In addition, the slope of the RR/QT relationship was changed by indoramin 100 mg. These results suggest that indoramin may have Class III antiarrhythmic activity. If such activity were to affect the SA node, it may explain at least in part the observed lack of reflex tachycardia after indoramin administration.
D000328:Adult; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007217:Indoramin / Q000494:pharmacology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D011897:Random Allocation; D013997:Time Factors
D007211:Indoles; D007217:Indoramin