Inhibition of anti-DNP antibody formation by high doses of DNP-polyacrylamide molecules; effects of hapten density and hapten valence.
High-dose inhibition of anti-DNP antibody formation by a series of DNP-polyacrylamide molecules of varying hapten density and hapten valence was measured. It was found that a molecule's inhibitory ability correlated directly with its hapten density, but not with its hapten valence nor with its own ability at optimal dose to stimulate an anti-DNP response.
D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004136:Dinitrobenzenes / Q000276:immunology / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006241:Haptens / Q000032:analysis*; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D046911:Macromolecular Substances; D051379:Mice; D009578:Nitrobenzenes / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D000099166:Polyacrylamides
D000180:Acrylic Resins; D004136:Dinitrobenzenes; D006241:Haptens; D046911:Macromolecular Substances; D009578:Nitrobenzenes; D000099166:Polyacrylamides