Comparison of netilmicin with cefoperazone for the treatment of severe or complicated urinary tract infections.
A randomised trial was undertaken to compare the efficacy and safety of netilmicin and cefoperazone for the treatment of severe or complicated urinary tract infections. Thirty-two patients completed the study. Fifteen of 16 patients treated with netilmicin and nine of 16 treated with cefoperazone were cured. This difference was statistically significant (p = 0.037). No serious side effects or toxicity occurred with either drug, although five patients developed diarrhea after treatment with cefoperazone.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002438:Cefoperazone / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000627:therapeutic use*; D011704:Pyelonephritis / Q000188:drug therapy; D011897:Random Allocation; D014552:Urinary Tract Infections / Q000188:drug therapy*
D005839:Gentamicins; D009428:Netilmicin; D002438:Cefoperazone