Amino acid sequence of bovine protein Z: a vitamin K-dependent serine protease homolog.
The amino acid sequence of protein Z has been determined from sequence analysis performed on fragments obtained by chemical and enzymatic degradations. The polypeptide consists of a single chain containing 396 amino acid residues (Mr 43 677). Comparison with the vitamin K-dependent plasma proteins reveals an extensive homology. The N-terminal part, containing 13 gamma-carboxyglutamic acid and one beta-hydroxyaspartic acid residue, is extensively homologous to and of similar length to the light chain of factor X. The remainder of protein Z is homologous to the serine proteases and of similar size to the heavy chain of factor Xa, but of the active site residues only aspartic acid-102 is present. Histidine-57 and serine-195 are replaced in protein Z by threonine and alanine, respectively. The physiological function of protein Z is still uncertain.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001798:Blood Proteins / Q000235:genetics; D002417:Cattle; D010450:Endopeptidases / Q000235:genetics; D009154:Mutation; D011499:Protein Processing, Post-Translational; D012697:Serine Endopeptidases
D000596:Amino Acids; D001798:Blood Proteins; C026080:plasma protein Z; D010450:Endopeptidases; D012697:Serine Endopeptidases