Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.
Five artemisinine-resistant mutants of Plasmodium falciparum have been isolated from a cloned parent following mutagenic treatment with N-methyl-N'-nitronitrosoguanidine. This observation may influence the strategy of the use of artemisinine or its derivatives. Mutant isolation should prove useful in the study of drug resistance to other antimalarials.
D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D004352:Drug Resistance, Microbial; D009154:Mutation; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D012717:Sesquiterpenes / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin