Chemical carcinogenesis: an overview.
A brief review is presented of some types of chemical carcinogens and their metabolic activation to DNA-binding intermediates, and of the influence of modifiers of carcinogenesis on the probability of tumor development. The relationship between human exposure to one group of carcinogens--the tobacco specific nitrosamines--and the development of tobacco-related cancers is discussed.
D002274:Carcinogens, Environmental / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000209:etiology*; D009602:Nitrosamines / Q000378:metabolism; D010947:Plants, Toxic; D012907:Smoking; D014026:Nicotiana
D002274:Carcinogens, Environmental; D009602:Nitrosamines; D004247:DNA