title: La Crosse virus G1 glycoprotein undergoes a conformational change at the pH of fusion.
abstract: La Crosse virus, a member of the family Bunyaviridae, can mediate cell-to-cell fusion after mild acidification. Either of its two envelope glycoproteins could potentially be responsible for this function. The large glycoprotein (G1) undergoes a conformational change at the pH of activation of the fusion function, resulting in both an alteration in the cleavage pattern produced by amino-acid-specific proteases, and in a change in its antigenicity, as defined by altered binding of monoclonal antibodies.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D002043:Bunyaviridae / Q000032:analysis* / Q000276:immunology; D002459:Cell Fusion; D006863:Hydrogen-Ion Concentration; D010447:Peptide Hydrolases; D010455:Peptides / Q000032:analysis; D011487:Protein Conformation; D014759:Viral Envelope Proteins / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D010455:Peptides; D014759:Viral Envelope Proteins; D010447:Peptide Hydrolases