Granulocytosis induced in vivo by a mouse marrow stromal cell line, BMA1, which produces colony stimulating factor.
Nude mice were inoculated with BMA1 cells. These are cells which produce granulocyte-macrophage colony stimulating factor (GM-CSF); They are derived from mouse bone marrow stromal cells transfected with adenovirus 5 DNA. Progressive neutrophilia developed as the tumor grew, but disappeared quickly after local tumor excision. Media conditioned with tumor cells had GM-CSF but neither erythropoietin nor burst-promoting activity. In all the tumors which developed, focal areas of bone formation were found among fibrosarcomatous tissues.
D000818:Animals; D001854:Bone Marrow Cells; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D003115:Colony-Stimulating Factors / Q000502:physiology*; D006098:Granulocytes / Q000166:cytology*; D007958:Leukocyte Count; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000209:etiology
D003115:Colony-Stimulating Factors