Toxicologically relevant disturbances of haemostasis.
The normal haemostatic process depends on the normal function of and regular interaction between the vascular wall, the plasmatic coagulation system and the blood platelets. The consequences of interference of chemical compounds with haemostasis are bleeding tendency and bleeding, thrombophilia and thrombosis or disseminated intravascular coagulation. Examples will illustrate that chemicals interfering with haemostasis have different mechanisms and sites of action.
D001778:Blood Coagulation Disorders / Q000139:chemically induced; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D001792:Blood Platelets / Q000187:drug effects; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D064420:Drug-Related Side Effects and Adverse Reactions; D005342:Fibrinolysis / Q000187:drug effects; D006474:Hemorrhagic Disorders / Q000139:chemically induced; D006487:Hemostasis / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D013921:Thrombocytopenia / Q000139:chemically induced; D014118:Toxins, Biological / Q000009:adverse effects
D001779:Blood Coagulation Factors; D014118:Toxins, Biological