The treatment of Trichomonas vaginalis vaginitis. An open controlled prospective study comparing a single dose of metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets.
Metronidazole tablets, benzoyl metronidazole suspension and tinidazole tablets each given as a single 2 g bolus dose in an open controlled prospective study were found to be effective forms of treatment for Trichomonas vaginalis vaginitis. The cure rates on wet smear preparations were 100%, 100% and 94,8% respectively, and symptomatic and observed improvements were excellent. There was a statistically significant difference between the response rates associated with both metronidazole preparations and tinidazole. The results of this study indicate that single-dosage bolus therapy can confidently be recommended in trichomonal infections and that it has a number of advantages.
D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D013535:Suspensions; D013607:Tablets; D013997:Time Factors; D014011:Tinidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D014247:Trichomonas Vaginitis / Q000188:drug therapy*
D009593:Nitroimidazoles; D013535:Suspensions; D013607:Tablets; D014011:Tinidazole; C035348:benzoylmetronidazole; D008795:Metronidazole