title: The application of a collagen stabilizer to the gingiva of the beagle dog. Effect on ligature-induced periodontal disease.
abstract: The objective of this study was to determine the effect of crevicular application of a collagen stabilizer on ligature-induced periodontal disease in beagle dogs. Fourteen male and female dogs, 15 months of age, were studied. The mandibular first molars and third and fourth premolars were ligated for 6 months and moderate periodontitis resulted. Ligatures were removed for 2 months and then replaced for an additional 3 months to experimentally mimic the episodic changes seen in human periodontal disease. Following this phase, ligatures were removed and the animals were assigned to a placebo or treatment group. Medications were then applied intracrevicularly, three times a week over 5 months using an IMAX irrigator. Clinical indices measured were plaque index (PI), gingival index (GI), gingival crevicular fluid flow (GCF), attachment level (AL), pocket depth (PD) and standardized radiographic analysis of alveolar bone height. While overall changes in PI, GI and GCF were not significant, the results showed that alveolar bone regeneration was increased approximately twice as much in the treatment group as compared to the placebo group, PD improved by 20% vs. 12.5% (P less than 0.001) and AL improved by 8.8% vs. 4.5% (P less than 0.001). The data were also evaluated in terms of the response in more severe sites as compared to those less severe. The results of these evaluations showed the more severe sites to be significantly more responsive to treatment than the less severe sites.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000287:Administration, Topical; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs; D004846:Epithelial Attachment / Q000033:anatomy & histology; D005260:Female; D005881:Gingiva; D005883:Gingival Crevicular Fluid; D008026:Ligation; D008297:Male; D009930:Organic Chemicals; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000175:diagnosis; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography
chemical_list: D000893:Anti-Inflammatory Agents; D009930:Organic Chemicals; C029841:CL 205241