Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes.
The T cell mitogens, concanavalin A and the monoclonal antibody OKT3, cause a rapid activation of ornithine decarboxylase (ODC) activity in human T lymphocytes, maximal within 10 min of mitogen addition. Nonmitogenic ligands to T cell surface structures do not induce ODC. The enzyme induction is dependent upon an intact mobility of ligand-receptor complex, requires a functioning energy metabolism, but is independent of de novo protein synthesis. The early induction of pre-existing ODC molecules appears to be specifically linked to the initiation of T lymphocyte proliferation.
D003513:Cycloheximide / Q000494:pharmacology; D004734:Energy Metabolism; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008934:Mitogens / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D008024:Ligands; D008934:Mitogens; D003513:Cycloheximide; D009955:Ornithine Decarboxylase