Distinct monoamine oxidase A and B populations in primate brain.
Monoclonal antibodies specific for monoamine oxidase (MAO) A and MAO B, respectively, were used to localize these enzymes in primate brain. The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. These data illustrate the physiological independence of MAO A and B and show that neurons may be specialized for their degradative as well as their synthetic functions.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D006801:Humans; D008252:Macaca fascicularis; D051379:Mice / Q000276:immunology; D008995:Monoamine Oxidase / Q000276:immunology / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D010286:Paraventricular Hypothalamic Nucleus / Q000201:enzymology; D011725:Pyridines / Q000494:pharmacology; D011903:Raphe Nuclei / Q000201:enzymology; D051381:Rats; D012701:Serotonin / Q000502:physiology; D013378:Substantia Nigra / Q000201:enzymology
D000911:Antibodies, Monoclonal; D011725:Pyridines; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D008995:Monoamine Oxidase