Palindromic rheumatism in two non-identical brothers with identical HLA including DR4.
Two brothers, aged 52 and 44, who suffered from palindromic rheumatism (PR) for 12 and 15 years were studied. The disease remained palindromic in the older brother, while chronic deformities developed early in the course of the disease in the younger. Their identical HLA locus was A9,Aw19(29); B12,Bw22; Cw1; DR1, DR4.
D000328:Adult; D006680:HLA Antigens / Q000032:analysis*; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012216:Rheumatic Diseases / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D015798:HLA-DR1 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II