Chemotherapy of Aspergillus fumigatus keratitis: an experimental study.
An experimental Keratitis study of Aspergillus fumigatus was performed in 130 rabbits divided into 12 groups of ten animals each. Three antifungal drugs (myconazole, amphotericin B and pimaricin) were tested using two procedures (topical drops and subconjunctival injections) and two different concentrations (500 and 10 000 times the MIC). In each case, the drugs were applied every 3 h starting 14 h after inoculation. Miconazole was useful at 10 mg/ml concentration by topical drops and subconjunctival injections, but was less useful at 5 mg/ml. Amphotericin B was useful at 5 mg/ml concentration by topical drops and less useful at 2 mg/ml. No differences were found between the two concentrations by subconjunctival administration. Pimaricin was useful by topical drops at 50 mg/ml concentration and less useful at 10 mg/ml as well as by subconjunctival injections.
D000287:Administration, Topical; D000666:Amphotericin B / Q000008:administration & dosage; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D003228:Conjunctiva; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D007267:Injections; D007634:Keratitis / Q000188:drug therapy*; D008297:Male; D008825:Miconazole / Q000008:administration & dosage; D010866:Natamycin / Q000008:administration & dosage; D011817:Rabbits
D008825:Miconazole; D000666:Amphotericin B; D010866:Natamycin