The effect of TP-5 and its analogs on skin grafts in mice.
The immunostimulatory action of oligopeptides RGH-0205 (Arg-Lys-Asp), RGH-0206 (Arg-Lys-Asp-Val) and TP-5 (Arg-Lys-Asp-Val-Try) was measured using the B10LP to C57BL skin graft system and the determination of splenic T cell ratio. While thymectomy increased the period between skin grafting and rejection, each of the oligopeptides increased the number of splenic T cells and in some extent restored the rejection capacity of thymectomised C57Bl mice, presumably by restoration of thymic hormone function.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009842:Oligopeptides / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013934:Thymectomy; D016305:Thymopentin; D013946:Thymopoietins / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014181:Transplantation Immunology / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D006728:Hormones; D009842:Oligopeptides; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; C045801:RGH 0205; C045802:thymocartin; D016305:Thymopentin