[Effect of smoking on the concentration and activity of serum alpha-1 anti-protease according to Pi phenotype].
In an epidemiological study on the respiratory pathology of 1 100 iron miners, the alpha 1 protease inhibitor concentration (alpha 1 Pi) and the elastase inhibitory capacity (EIC) of serum were determined in 97 men with deficient Pi phenotype (73 MS, 24 MZ or S) compared with PiM non deficient men adjusted for age and tobacco consumption. There were differences in alpha 1 Pi concentration and in alpha 1 inhibitory capacity between phenotype groups in agreement with the results of other studies. Smoking produces an increase of serum alpha 1 Pi concentration and EIC in all Pi phenotype groups. This increase is more important (30%) in the MS group than in the others (MZ 20%, M 12%). This effect which appears to be related to smoking intensity does not seem to have a link with an alteration or a modification of the molecular function which is at a rate of 70% in all cases.
D000328:Adult; D005602:France; D006801:Humans; D007501:Iron; D008297:Male; D008875:Middle Aged; D008906:Mining; D009784:Occupational Diseases / Q000201:enzymology / Q000453:epidemiology; D010641:Phenotype; D012140:Respiratory Tract Diseases / Q000201:enzymology* / Q000453:epidemiology; D012907:Smoking; D019896:alpha 1-Antitrypsin Deficiency
D007501:Iron
Effet du tabagisme sur la concentration et l'activité de l'alpha-1 anti-protéase sérique selon le phénotype Pi.