Opsonic activity of MCP-1 and MCP-2, cationic peptides from rabbit alveolar macrophages.
MCP-1 and MCP-2, cationic peptides derived from rabbit alveolar macrophages, enhanced the ability of these cells to ingest Staphylococcus aureus, Klebsiella pneumoniae, Bordetella bronchiseptica, and Candida albicans in vitro. The opsonic effect of MCP-1 was potentiated by Ca++ and Mg++ and was associated with binding of the peptide to alveolar macrophages and microorganisms. MCP-1 and MCP-2 may contribute to the ability of alveolar macrophage to ingest microorganisms that gain entry to the lower respiratory tract.
D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001884:Bordetella; D002176:Candida albicans; D066298:In Vitro Techniques; D007711:Klebsiella pneumoniae; D008264:Macrophages / Q000502:physiology*; D009895:Opsonin Proteins / Q000502:physiology*; D010587:Phagocytosis; D011506:Proteins / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000166:cytology*; D011817:Rabbits; D013211:Staphylococcus aureus
D023181:Antimicrobial Cationic Peptides; D009895:Opsonin Proteins; D011506:Proteins