[Vascular collagens. General review].
The analysis of vascular collagens proved difficult due to high insolubility. In the seventies, compositional studies concerned a fraction of 30% of total collagen. Type I collagen, far less soluble than type III, was not fully extracted, resulting in an overevaluation of type III collagen. When the proportions of collagens are measured on the totality of the material, type I collagen represents 60%, type III, 30% and the remaining 10% are constituted by type V and minor collagens. Atheromatous plaques contain a little more collagen than normal arteries and the proportion of type I remains 60%. Whereas several experiments demonstrated that slices of atheromatous arteries in vitro synthesize more collagen than slices of normal arteries, the possible mechanism of interaction between plasma lipoproteins (normal or abnormal) and collagen metabolism remains unknown. Vein and capillary collagens have been rarely studied. Basement membrane collagen does not seem to be increased in quantity in the thickened basement membrane of diabetic patients capillaries.
D000818:Animals; D001158:Arteries / Q000032:analysis / Q000378:metabolism; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D001808:Blood Vessels / Q000032:analysis* / Q000378:metabolism; D002196:Capillaries / Q000032:analysis / Q000378:metabolism; D003094:Collagen / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D014680:Veins / Q000032:analysis / Q000378:metabolism
D003094:Collagen
Les collagènes vasculaires. Revue générale.