title: Induction of chronic polyarthritis in rabbits by hyperimmunization with Escherichia coli. I. Pathologic and serologic features in two breeds of rabbits.
abstract: Hyperimmunization of 147 rabbits (outbred Japanese white rabbits and New Zealand white [NZW] rabbits bred in a closed colony) with heat-killed Escherichia coli 0:14 in Freund's incomplete adjuvant resulted in the animals developing a chronic polyarthritis resembling rheumatoid arthritis (RA). While both Japanese white and NZW rabbits showed a high incidence of the induced arthritis, a higher proportion of NZW rabbits developed the disease, suggesting that genetic influence is important in the development of RA-like illness. This experimental model may be useful for the study of RA.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D005552:Forelimb / Q000473:pathology; D006614:Hindlimb / Q000473:pathology; D007596:Joints / Q000473:pathology; D008297:Male; D011817:Rabbits / Q000235:genetics
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines