Antibody deficiency with normal immunoglobulins in a child with hypoplastic anemia.
We report a young child with hypoplastic anemia and antibody deficiency with normal serum immunoglobulin levels. Studies of antibody responses to bacteriophage phi X 174 revealed an amnestic response but was predominantly limited to IgM. A similar response was observed following booster tetanus toxoid immunization. Analysis of in vitro pokeweed mitogen-induced immunoglobulin synthesis by the patient's B cells suggested an intrinsic B-cell defect.
D000741:Anemia, Aplastic / Q000276:immunology*; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007156:Immunologic Memory; D008211:Lymphocyte Cooperation; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M