A controlled comparison of tiaprofenic acid and ibuprofen in osteoarthritis.
A multicentre double-blind crossover study of tiaprofenic acid (600 mg daily) against ibuprofen (1.2 g daily) was undertaken in 77 patients with osteoarthritis to compare their efficacy and tolerance. No difference was found between the two agents, both giving pain relief and being safe and acceptable to the majority of patients. It is concluded that in this short-term study, both agents offer effective and safe treatment for osteoarthritis.
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D011422:Propionates / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid; D007052:Ibuprofen