The prevalence of HLA-DR4 and HLA-DR3 in healthy persons with rheumatoid factor.
The frequency of the HLA antigen DR4 has been determined in healthy individuals with serum IgM RF. HLA DR4 was found in 11.6% of these persons as compared with 27% in healthy controls. Thus, no association between IgM RF and HLA-DR4 could be found in this material of healthy individuals. HLA-DR3 was found in 35% of healthy RF-positive persons, which was no different from the 30% prevalence among healthy controls. HLA-DR3 did not seem to be associated with high immune responsiveness of RF in RF-positive individuals.
D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway; D012217:Rheumatoid Factor / Q000032:analysis*
D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D012217:Rheumatoid Factor