title: [Context analysis of polynucleotide sequences. Methods of detecting non-random repeats. I. Direct repeats in genes of beta-, beta'-, sigma subunits of Escherichia coli RNA-polymerase].
abstract: A new method of contextual analysis of polynucleotide sequences in developed. The method finds nonrandom repeats in the sequences of N bases in length with given nucleotide frequencies. The coding regions of genes specifying beta-, beta'-, sigma-subunits of E. coli RNA polymerase were analyzed. The high content of short repeats was found to correspond to the secondary structure of globular proteins coded by the genes. The possible evolutionary role of the nonrandom direct repeats in coding regions of genes is discussed.
mesh_terms: D004261:DNA Replication; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005796:Genes; D005798:Genes, Bacterial; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D012335:RNA, Ribosomal / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D006454:Hemoglobins; D012335:RNA, Ribosomal; D012321:DNA-Directed RNA Polymerases
vernacular_title: Kontekstnyĭ analiz polinukleotidnykh posledovatel'nosteĭ. Metody vyiavleniia nesluchaĭnykh povtorov. I. Priamye povtory v genakh beta-, beta'-, sigma-sub''edinits RNK-polimerazy iz Escherichia coli.