1H- and 2H-n.m.r. studies of water in gamma-irradiated phosphatidylcholine multilamellar liposomes.
1H- and 2H-n.m.r. studies of gamma-irradiation-induced variations in the dynamic structure and proportional amounts of free, trapped and bound water species in multilamellar liposomes are reported and discussed. Bound water is shown to increase with dose and to be present in two different structural states. A dose-dependent decrease in the 1H-n.m.r. relaxation times of bound water following gamma-irradiation is reported. Variations are suggested as being due to large scale changes at the bilayer surface.
D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D008081:Liposomes / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000528:radiation effects*; D014867:Water / Q000528:radiation effects*
D003037:Cobalt Radioisotopes; D008081:Liposomes; D010713:Phosphatidylcholines; D014867:Water