title: Experimental and clinical trials of long acting oxytetracycline in the treatment of canine ehrlichiosis.
abstract: Four splenectomized dogs were experimentally infected with Ehrlichia canis and treated at the point of illness with long acting (LA) Oxytetracycline at different dosages. Terramycin LA, when given at a dose of 20 mg/kg body weight (deep intramuscularly) twice, at a four-day interval, was found to have effectively controlled the disease and has replaced the usual 7-14 successive days' treatment regimen when other groups of tetracycline drugs are used. Predef 2X at the rate of 2 mg given intramuscularly concurrently eliminated the local inflammatory reaction caused by the injection of Terramycin LA. Twenty-four out of the 26 naturally infected dogs which were treated in a similar way were completely cured; one died before it could receive the full treatment, and another received a second medication five weeks after the first treatment, showing recurrent epistaxis; blood samples taken from this dog were negative for E. canis.
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000662:veterinary; D003692:Delayed-Action Preparations; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004536:Ehrlichia; D007273:Injections, Intramuscular / Q000662:veterinary; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D012288:Rickettsiaceae Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D003692:Delayed-Action Preparations; D010118:Oxytetracycline