title: Effect of long-term oral nifedipine therapy on left ventricular regional wall function at rest and during supine bicycle exercise.
abstract: 15 patients, 1 to 3 year after coronary bypass surgery, underwent symptom limited supine bicycle exercise tests without nifedipine and after acute and chronic (3 months) administration of the drug. Haemodynamic variables were monitored as was epicardial marker motion, using biplane cineradiography during exercise, the markers having been implanted at the time of surgery. We found significant (P less than 0.001) reductions in end-diastolic and end-systolic regional dimensions at maximal exercise after oral nifedipine, associated with a significant reduction in exertional angina, which persisted during long-term treatment. No adverse effects of the drug were observed.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000188:drug therapy*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D009543:Nifedipine / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy
chemical_list: D009543:Nifedipine