title: Tissue reactions to two root canal sealers containing formaldehyde.
abstract: Tissue reaction to root fillings using either Endomethasone or N2 was investigated in the premolar teeth of dogs. Periapical inflammation was frequently observed, but of greater significance was the universal evidence of ankylosis and the accompanying resorption of teeth filled with N2. One tooth filled with Endomethasone also exhibited this condition. The results of this study do not support the use of these root canal sealers that contain formaldehyde.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000844:Ankylosis / Q000139:chemically induced; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001641:Bicuspid; D003907:Dexamethasone / Q000009:adverse effects*; D004285:Dogs; D004338:Drug Combinations / Q000009:adverse effects; D005054:Eugenol / Q000009:adverse effects*; D005557:Formaldehyde / Q000009:adverse effects*; D006854:Hydrocortisone; D010485:Periapical Periodontitis / Q000139:chemically induced; D012387:Root Canal Filling Materials / Q000009:adverse effects*; D013943:Thymol / Q000009:adverse effects / Q000031:analogs & derivatives*; D014076:Tooth Diseases / Q000139:chemically induced; D015032:Zinc / Q000009:adverse effects*; D015034:Zinc Oxide / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D012387:Root Canal Filling Materials; C011244:corticosteroid methanetriol mixture; D005557:Formaldehyde; D013943:Thymol; D005054:Eugenol; D003907:Dexamethasone; C003799:N2 Dental Cement; D015032:Zinc; D015034:Zinc Oxide; D006854:Hydrocortisone