HLA-B27 and ankylosing spondylitis: an anti-idiotypic model.
Ankylosing spondylitis (AS) is strongly associated with possession of the HLA (Human Leucocyte Antigen)-B27 histocompatibility alloantigen. It is proposed that immunological tolerance to HLA-B27 allows the emergence of a lymphocyte clone with specificity for connective tissue antigens. Such a pathogenic clone would possess idiotypic determinants cross-reactive with determinants on HLA-B27. This hypothesis was investigated using immunoglobulins from HLA-B27 subjects with active definite AS. Immunoglobulin fractions were assayed for HLA-B27-like idiotopes by inhibition of the cytotoxicity of an anti-HLA-B27 antiserum, and by an ELISA technique. The postulated HLA-B27-like idiotope was not detected using these methods.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006801:Humans; D007108:Immune Tolerance; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008954:Models, Biological; D013167:Spondylitis, Ankylosing / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens; D015796:HLA-B27 Antigen; D007130:Immunoglobulin Idiotypes