Induction of Ia antigens on thyroid cultures by syngeneic T lymphocytes: a model of autoimmune disease.
We previously reported that the expression of Ia antigens on cultured monolayers of murine thyroid epithelial cells (TEC) occurred with a particular distribution exclusively on the basal part of the cultured thyroid cells, while class I antigens of the major histocompatibility complex (MHC) are only detected on the apical surface. It appears that deposition of syngeneic lymphocytes induces, 24 h later, Ia expression on the apical side of cultured TEC, the surface that is in direct contact with the responder lymphocytes during syngeneic sensitization of T lymphocytes. We hypothesized that this phenomenon could represent, in syngeneic situations, the restriction process in antigen recognition by T cells, as demonstrated by Ia restricted primary syngeneic sensitization (PSS) on murine TEC.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D002478:Cells, Cultured; D004848:Epithelium / Q000276:immunology; D000949:Histocompatibility Antigens Class II; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D013601:T-Lymphocytes / Q000276:immunology*; D013959:Thyroid Diseases / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology*
D000949:Histocompatibility Antigens Class II