[Evaluation of leukemogenic and immunogenic properties of leukemic cells modified by neuraminidase of non-cholera Vibrios on the model of Rauscher leukemia].
The leukemogenic activity of modified leukemic cells was studied in experiments on the 385 BALB/c mice with Rauscher leukemia by transplantation of different amount of treated cells. Immunogenicity of modified leukemic cells was estimated under conditions of three-fold immunization of animals 2 days later by the cells dose equal to 1.10(6) which began 24 h after the leukemia transplantation. The effect of immunotherapy of neuraminidase-modified leukemic cells results in elongation of animal lifetime, presence of less pronounced changes in the peripheral blood and spleen as well as in stimulation of cell immunity factors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D007167:Immunotherapy / Q000379:methods*; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D017710:Lymphocyte Transfusion; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009439:Neuraminidase; D011925:Rauscher Virus; D013154:Spleen / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D014733:Vibrio / Q000201:enzymology
D009439:Neuraminidase
Otsenka leĭkemogennykh i immunogennykh svoĭstv modifitsirovannykh neĭraminidazoĭ nekholernykh vibrionov leĭkoznykh kletok na modeli leĭkoza Raushera.