Bone formation enhanced by induction. Bone growth in titanium implants in rats.
Bone-inducing materials have been investigated for the purpose of augmenting bone formation in implants made of porous fiber titanium. The bone-inducing materials used were: (1) Bone from the iliac crest of inbred rats (isografts), (2) Antigen-extracted, autolyzed, demineralized bone from outbred rats (AAA bone a.m. Urist), and (3) AAA bone combined with bone marrow from inbred rats. Tubes of fiber titanium were packed with bone-inducing materials and implanted in the back musculature of inbred rats. Bone formation was assessed by labelling with 3H-proline (collagen synthesis) and 47Ca (mineral deposit) and by content of calcium of the harvested implants. Isografts and AAA bone with marrow yielded a substantial amount of new bone. Without the marrow, AAA bone yielded very small amounts of new bone.
D000818:Animals; D016026:Bone Marrow Transplantation; D016025:Bone Transplantation; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis; D008297:Male; D010012:Osteogenesis; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014025:Titanium; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D003094:Collagen; D014025:Titanium; D002118:Calcium