The effect of 2'deoxyguanosine on human lymphocyte responses. I. 2'deoxyguanosine enhances T lymphocyte responses.
Low concentrations (40 microM) of the purine nucleoside metabolite 2'deoxyguanosine (2'dGuo), were shown to enhance both phytohaemagglutinin- and concanavalin A-induced T cell transformation. Evidence is presented which indicates that this enhancement may be due to the inhibition of suppressor T cell function resulting in the promotion of T cell growth factor production. T cell responses were only inhibited at concentrations of 2'dGuo which were toxic to the lymphocytes.
D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D003849:Deoxyguanosine / Q000494:pharmacology*; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D007376:Interleukin-2; D010835:Phytohemagglutinins; D003208:Concanavalin A; D003849:Deoxyguanosine