Synthesis and analgesic activity of new tricyclic pyrazolo[3,4-b]pyridines.
The title compounds have been obtained in a two-step synthesis from 5-amino-4-(1-cycloalkenyl)pyrazoles. Among the synthetized compounds, the 6,7,8,9-tetrahydro-1,3-dimethyl-3H-pyrazolo[3,4-c]isoquinoline, showed interesting antiinflammatory and analgesic activity.
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D003368:Gossypium; D006099:Granuloma / Q000188:drug therapy / Q000209:etiology; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007546:Isoquinolines; D011720:Pyrazoles; D011725:Pyridines; D002351:Carrageenan