The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine.
P. falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after chloroquine administration. Intra-erythrocytic parasite damage was seen by light and electron microscopy. The significance of the results is discussed with relevance to non-specific immune mechanisms, and the damage induced by these mechanisms compared with that from chloroquine.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D004660:Encephalitis / Q000276:immunology; D004912:Erythrocytes / Q000469:parasitology / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000097:blood / Q000276:immunology / Q000469:parasitology*; D008581:Meningitis / Q000276:immunology; D008854:Microscopy, Electron; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure
D002738:Chloroquine