[Recombination between the fragile site Xq27 and the gene for coagulation factor IX].
Using the Taq I restriction polymorphism of a factor IX probe, we analysed the segregation of this gene and that of the fragile site Xq27. The ancestor of this family was a healthy carrier male. Of twelve informative meioses, at least four recombinations were detected. The hypothesis of a particular instability of the distal part the long arm of the X chromosome is reconsidered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005164:Factor IX / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations / Q000235:genetics*
D005164:Factor IX
Recombinaison entre le site fragile Xq27 et le gène du facteur IX de la coagulation.