[Preponderant synthesis of rheumatoid factors by synovial plasma cells in rheumatoid polyarthritis].
Plasma cells synthesising rheumatoid factor have been identified by immunofluorescent studies of sections of cells eluted from synovial membranes poor in macrophages. More than 90% of the IgM plasma cells produce rheumatoid factor, while 50 to 60% of IgG plasma cells and only 10% of IgA plasma cells produce rheumatoid factor. The equivalent results obtained in patients with sero-positive and sero-negative rheumatoid arthritis suggest that auto-immunisation between the IgG plays the same determinant role in the pathophysiology of the two types of rheumatoid arthritis.
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007158:Immunologic Techniques; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism*; D012217:Rheumatoid Factor / Q000096:biosynthesis*; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor
Synthèse prépondérante de facteurs rhumatoïdes par les plasmocytes synoviaux au cours de la polyarthrite rhumatoïde.