Comparison of the effects of different anti-inflammatory drugs on synovial fluid prostanoid concentrations in patients with rheumatoid arthritis.
The effects of one-day treatment with nine nonsteroidal anti-inflammatory drugs and prednisolone on human synovial fluid concentrations of prostanoids were studied. The doses were calculated so as to be approximately equipotent according to clinical experience and the recommendations of the manufacturers. Most of the drugs used reduced clearly PGE2 and TxB2 levels in synovial fluid, but only a slight diminution in 6-keto-PGF1 alpha values was found. Carprofen, diclofenac, indomethacin, naproxen and tolfenamic acid reduced significantly the synovial fluid PGE2 concentrations. Diclofenac and indomethacin also reduced significantly the synovial TxB2 concentrations.
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000082:Acetaminophen / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D001241:Aspirin / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use; D015232:Dinoprostone; D006146:Guanidines / Q000627:therapeutic use; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D009288:Naproxen / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D011453:Prostaglandins / Q000032:analysis*; D011458:Prostaglandins E / Q000032:analysis; D011799:Quinazolines / Q000627:therapeutic use; D013582:Synovial Fluid / Q000032:analysis* / Q000187:drug effects; D013929:Thromboxane B2 / Q000032:analysis; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D002227:Carbazoles; D006146:Guanidines; D011453:Prostaglandins; D011458:Prostaglandins E; D011799:Quinazolines; D062367:ortho-Aminobenzoates; D004008:Diclofenac; C028998:timegadine; D000082:Acetaminophen; C009500:tolfenamic acid; C011385:proquazone; D013929:Thromboxane B2; D009288:Naproxen; D015121:6-Ketoprostaglandin F1 alpha; D011239:Prednisolone; C007005:carprofen; D015232:Dinoprostone; D001241:Aspirin; D007213:Indomethacin