Influence of microinjection of insulin into ventromedial hypothalamus on acetate metabolism in liver slices of rabbit.
Insulin was injected directly into the ventromedial hypothalamic nuclei (VMH) of rabbits, and changes in hepatic acetate metabolism were studied. The injection of 50 microU insulin into the VMH of intact rabbits decreased the rates of 14C transfer from 14C-1-acetate into glucose and cholesterol ester in liver slices. But after insulin injection into the parietal cortex of intact rabbits and into the VMH of rabbits with VMH lesions, hepatic acetate metabolism did not differ from that of the control rabbits, which received saline injection into the same brain regions. These observations support the hypothesis that the VMH are parts of an insulin-sensitive brain regulator system in the hepatic acetate metabolism.
D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000818:Animals; D001812:Blood-Brain Barrier; D002788:Cholesterol Esters / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007033:Hypothalamus, Middle / Q000187:drug effects* / Q000502:physiology; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008845:Microinjections; D009474:Neurons / Q000502:physiology; D010296:Parietal Lobe / Q000187:drug effects; D011817:Rabbits
D000085:Acetates; D002788:Cholesterol Esters; D007328:Insulin; D005947:Glucose; D019342:Acetic Acid