[Comparative pharmacological analysis of the mechanisms of thrombocyte aggregation induced by bacterial toxins and ADP].
It has been demonstrated in experiments in vitro that exotoxin and endotoxin of Shigella sonnei produce the concentration-dependent rabbit platelet aggregation. Acetylsalicylic acid and theophylline substantially inhibit the ADP-induced aggregation and suppress to a less degree the effects of bacterial toxins. Monoiodine acetate inhibits aggregation induced by ADP and potentiates the aggregating action of toxins.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001427:Bacterial Toxins / Q000494:pharmacology*; D004731:Endotoxins / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D007461:Iodoacetates / Q000494:pharmacology; D019807:Iodoacetic Acid; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012764:Shigella sonnei; D013210:Staphylococcus; D013806:Theophylline / Q000494:pharmacology
D001427:Bacterial Toxins; D004731:Endotoxins; D007461:Iodoacetates; D000244:Adenosine Diphosphate; D013806:Theophylline; D001241:Aspirin; D019807:Iodoacetic Acid
Sravnitel'nyĭ farmakologicheskiĭ analiz mekhanizmov agregatsii trombotsitov, indutsirovannoĭ bakterial'nymi toksinami i ADF.