title: Distribution of class IIDQ antigens on normal and leukemic lymphoid cells.
abstract: The distribution of DQ as well as DR antigens was examined on lymphoid and monocytic cells at different stages of differentiation. In the B cell series, both immature and differentiating (under Staphylococcus aureus or pokeweed mitogen stimulation) B cells often lacked DQ molecules; among surface IgM+ and IgD+ cells, both DQ and DR molecules were detected except on cells from 30% of the lymphoid malignancies studied. T cells expressed DQ molecules only after stimulation; a DQ-DR+ phenotype was observed in a large number of cells after allogeneic stimulation, in certain antigen-specific T cell lines as well as in T cell lymphomas, suggesting that class II antigens had a distinct pattern of regulation. In the monocytic lineage, DQ molecules were expressed by most lymph node monocytes and only a low percentage (20%) of circulating monocytes.
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007938:Leukemia / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000951:Antigens, Neoplasm; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II