The influence of thymic humoral factor on systemic lupus erythematosus lymphocyte function.
The influence of thymic humoral factor, THF, on systemic lupus erythematosus, SLE, lymphocyte function was investigated. Increasing numbers of SLE T-cells, rosetted at 4 degrees C or 37 degrees C, were cultured with allogeneic normal B-cells and the change in IgM synthesis was assessed. Lymphocytes of some SLE patients showed improved suppression with THF when rosetted at 37 degrees C. Normal control lymphocytes did not show a net change in suppression with THF. The subgroup of SLE patients that showed improved suppression with THF in vitro might be a more appropriate group for in vivo therapeutic trials with thymic hormone, TH, than SLE patients in general.
D001402:B-Lymphocytes / Q000276:immunology; D002469:Cell Separation / Q000379:methods; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology; D013935:Thymic Factor, Circulating / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D007075:Immunoglobulin M; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating