Atypical fibroxanthoma. A study with antibody to S-100 protein.
Fourteen biopsy specimens from ten patients with atypical fibroxanthoma were studied with the peroxidase-antiperoxidase method for binding of S-100 antibody. Six specimens from four patients were minimally positive. The S-100-positive cells were observed in greatest concentrations at the periphery of the lesions and were associated with perivascular inflammatory cells. By this method, it appears that there is not a Langerhans' cell type of atypical fibroxanthoma. The S-100 antibody can help differentiate desmoplastic juvenile melanoma and malignant melanoma from atypical fibroxanthoma.
D000911:Antibodies, Monoclonal; D003937:Diagnosis, Differential; D005350:Fibroma / Q000032:analysis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008545:Melanoma / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis / Q000473:pathology*
D000911:Antibodies, Monoclonal; D009418:S100 Proteins