Degradation of somatomedins by the thioredoxin system.
The insulin disulfide reducing thioredoxin system from E. coli was used to investigate a possible mechanism of degradation for the two somatomedins, insulin-like growth factor I and II (IGF-I and -II). The amounts of IGF-I and -II remaining after degradation were measured by use of human placenta radioreceptor assay. The results show that both IGF-I and -II were as sensitive to disulfide reduction as insulin.
D001426:Bacterial Proteins / Q000378:metabolism*; D004220:Disulfides / Q000378:metabolism; D004926:Escherichia coli / Q000032:analysis*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011869:Radioligand Assay; D013002:Somatomedins / Q000378:metabolism*; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism*
D001426:Bacterial Proteins; D004220:Disulfides; D007328:Insulin; D010455:Peptides; D013002:Somatomedins; D013879:Thioredoxins; D013880:Thioredoxin-Disulfide Reductase