[Prostaglandin E2 and F2 alpha and 5-hydroxyeicosatetraenoic acid levels in the blood of immobilized rats: effect of dihydrocucurbitacin D diglucoside].
Content of prostaglandin E2 was decreased more than 6-fold in blood plasma of immobilized rats; on the other hand, concentration of 5-hydroxytetraenoic acid was increased more than 3-fold. No distinct alterations were noted in the prostaglandin F2 alpha content. Intraperitoneal preadministration of 0.1 mg/kg of 2 beta, 25-di (beta-D-glucopyranosyl)-16 alpha; 20-dihydroxy-3, 11, 22-trioxo-cucurbit-5-en into the animals, which as far as is known to augment the working capacity of mice, prevented the stress-induced alterations in the eicosanoid contents in blood plasma.
D000818:Animals; D015237:Dinoprost; D015232:Dinoprostone; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood*; D007103:Immobilization; D008297:Male; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood*; D051381:Rats; D014315:Triterpenes / Q000494:pharmacology*
D006893:Hydroxyeicosatetraenoic Acids; D011458:Prostaglandins E; D011460:Prostaglandins F; D014315:Triterpenes; C054202:cucurbitacin R 2,25-diglucoside; D015237:Dinoprost; D015232:Dinoprostone
Soderzhanie prostaglandinov E2, F2 alpha i 5-oksiéĭkozatetraenovoĭ kisloty v krovi krys pri immobilizatsii: vliianie digliukozida digidrokukurbitatsina D]