[New aspects in the treatment of hemangioma].
This paper describes the successful therapy of cavernous and capillary haemangiomata by inducing thrombosis with Tissucol homologous fibrinogen and thrombin. After angiography, infants and small children were injected with Tissucol directly into the vascular convolution at two weekly intervals, resulting in complete thrombosis with subsequent fibrosis, leading to diminution of the haemangioma until it finally disappeared. Histological examination showed fibrosis and sclerosis, with granular tissue rich in fibrinoblasts as a manifestation of a partially organised thrombosis. There were no traces of inflammation. In a large number of adults, reduction of the haemangioma was successfully achieved by injections of Tissucol, leading to thrombosis, followed by immediate surgical removal of the entire haemangioma. Treatment of small haemangiomata by cryosurgical measures with liquid nitrogen, as recommended by Lexer in 1921, was likewise successfully applied.
D002675:Child, Preschool; D003131:Combined Modality Therapy; D003452:Cryosurgery; D004338:Drug Combinations / Q000008:administration & dosage; D004621:Embolization, Therapeutic / Q000379:methods*; D005153:Facial Neoplasms / Q000628:therapy*; D005176:Factor XIII / Q000008:administration & dosage; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000008:administration & dosage; D005500:Follow-Up Studies; D006391:Hemangioma / Q000628:therapy*; D006392:Hemangioma, Cavernous / Q000628:therapy*; D006801:Humans; D008048:Lip Neoplasms / Q000628:therapy; D013917:Thrombin / Q000008:administration & dosage; D014014:Tissue Adhesives / Q000008:administration & dosage
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin
Neue Aspekte zur Hämangiom-Behandlung.