[Antibacterial activity of ceftriaxone].
In this study the author reports the main in vitro characteristics of ceftriaxone, a new aminothiazolyl methoxy-iminocephalosporin. The relationship between its structure and the antibacterial activity compared with cefotaxime reveals an expected longer antibacterial efficacy due to a long elimination half-life (8 h). It has been shown that ceftriaxone is highly stable against most either plasmid or chromosome-mediated beta-lactamases. Several studies demonstrated that the spectrum of ceftriaxone included Gram-positive cocci as well as most Gram-negative bacilli even beta-lactamase producers; a variable in vitro activity against Gram-negative aerobic bacteria (Pseudomonas sp., Acinetobacter sp.) has been proved, with a frequent synergistic bactericidal activity when combined with aminoglycosides, or with other beta-lactam antibiotics (carbenicillin, piperacillin). Multiple PBPs targets have been identified, including PBP1b, 2 and 3, leading to filamentation of E. coli, Ps. aeruginosa and Haemophilus cells. As a result, ceftriaxone displays a high intrinsic in vitro activity against troublesome strains and might be considered as a promising new cephalosporin for treatment of severe infections.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002443:Ceftriaxone; D004357:Drug Synergism; D006602:Hexosyltransferases; D008826:Microbial Sensitivity Tests; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013329:Structure-Activity Relationship; D001618:beta-Lactamases / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D002443:Ceftriaxone; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases; D002439:Cefotaxime
Activité antibactérienne de la ceftriaxone.