Diethylcarbamazine-mediated clearance of Brugia pahangi microfilariae in immunodeficient nude mice.
Congenitally athymic nude C3H/HeN mice, microfilaremic with Brugia pahangi, were treated with diethylcarbamazine citrate (DEC). A single oral dose (100 mg/Kg body weight) of DEC resulted in the rapid reduction of numbers of circulating microfilariae in nude, thymus-grafted nude and complement-depleted nude mice. Antibodies of the IgM and IgG isotypes were not detected in the serum of microfilaremic nudes or on the microfilarial surface. These results suggest that DEC-mediated clearance of microfilariae from the circulation of nude mice is probably independent of thymus-dependent immunological mechanisms.
D000818:Animals; D002009:Brugia / Q000276:immunology; D004049:Diethylcarbamazine / Q000627:therapeutic use*; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005260:Female; D005455:Fluorescent Antibody Technique; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008209:Lymphedema / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008819:Mice, Nude / Q000469:parasitology; D013950:Thymus Gland / Q000502:physiology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004049:Diethylcarbamazine