A comparison of the effects of topical cyclosporine and topical steroid on rabbit corneal allograft rejection.
A comparison was made of the effects of topically applied cyclosporine, and topically applied prednisolone acetate, on the prolongation of corneal allograft survival in a recently developed prevascularized rabbit eye model. Animals were treated four times daily for 28 days postgrafting. Both drugs prolonged graft survival when compared with placebo or no treatment but the corticosteroid was significantly more effective than cyclosporine. Furthermore, anterior segment inflammation and graft vascularization were considerably less marked in animals treated with steroid. No cyclosporine could be detected by radioimmunoassay in anterior chamber fluid removed by paracentesis from grafted animals treated with cyclosporine, suggesting poor absorption of the drug across the cornea.
D000287:Administration, Topical; D000818:Animals; D000867:Anterior Chamber / Q000187:drug effects; D003315:Cornea / Q000098:blood supply; D016039:Corneal Transplantation; D003524:Cyclosporins / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D008297:Male; D009821:Oils / Q000627:therapeutic use; D000069463:Olive Oil; D000074241:Peanut Oil; D014677:Pharmaceutical Vehicles; D010938:Plant Oils; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011817:Rabbits
D003524:Cyclosporins; D009821:Oils; D000069463:Olive Oil; D000074241:Peanut Oil; D014677:Pharmaceutical Vehicles; D010938:Plant Oils; C009935:prednisolone acetate; D011239:Prednisolone