Cutaneous pre-B leukaemia cells with a T-lymphocyte antigen (T4).
A patient with acute lymphocytic leukaemia (ALL) is described in whom the cells originated in the pre-B cell lineage but showed an aberrant expression of T4 antigen. A B-cell origin of the leukaemic cells was indicated by reactivity for several monoclonal antibodies specific for the B-cell lineage and by cytoplasmic staining with FITC-labelled anti human mu chains.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D000941:Antigens / Q000032:analysis; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000941:Antigens