[Experimental immune arteriosclerosis in the rabbit. Immunogenic and pathogenic properties of glycoproteins and elastins in arterial tissue].
Rabbits immunized with kappa elastin produced arteriosclerosis and antibodies that bound to target-structures (elastic fiber sheaths, endothelial and smooth muscle cells). These antibodies were cytotoxic for cultured rabbit or rat arterial smooth muscle cells. Absorption of the antielastin antiserum with pig aorta or human serum glycoproteins inhibited its binding to target-structures and suppressed its in vitro cytotoxicity. These data are discussed.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D001011:Aorta / Q000276:immunology*; D001161:Arteriosclerosis / Q000276:immunology*; D002478:Cells, Cultured; D004549:Elastin / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D006023:Glycoproteins; D004549:Elastin
Artériosclérose expérimentale immune du lapin. Pouvoir immunogène et pathogène des glycoprotéines et élastines du tissu artériel.