Effect of subgingival scaling on systemic antibody responses to oral microorganisms.
The effects of scaling and root planing treatment on systemic antibody responses were studied in patients with periodontal disease and in normal subjects. Immunoglobulin G antibody in serum to a battery of oral microorganisms was assessed in an enzyme-linked immunosorbent assay before and after treatment in 31 individuals. The majority (96%) of the diseased patients exhibited elevated antibody to one or more of the microorganisms before the scaling regime. Significant increases in antibody levels in serum were noted in 16 of 19 patients after scaling, whereas only 2 of 12 nonscaled subjects showed similar changes during monitoring intervals of up to 3 years. The bacterial specificities of the increases were found to differ among the patients; however, a significant correlation to preexisting elevated antibody levels was observed. Peak levels of responses were noted at approximately 2 to 4 months posttreatment; antibody returned to pretreatment levels by 8 to 12 months. The predominant organisms for which changes were noted included the black-pigmented Bacteroides spp., Eikenella corrodens, Campylobacter concisus, and Actinobacillus actinomycetemcomitans. In 18 of 19 instances, the homologous microorganism was detected in the subgingival plaque when elevated antibody was present after treatment. These findings indicated that specific changes in host systemic responses accompany scaling and root planing treatment of periodontal disease patients. These alterations in the host response may provide an additional means by which successful therapy can be accomplished.
D000188:Actinobacillus / Q000276:immunology* / Q000302:isolation & purification; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001439:Bacteroides / Q000276:immunology* / Q000302:isolation & purification; D002167:Campylobacter / Q000276:immunology* / Q000302:isolation & purification; D003773:Dental Plaque / Q000382:microbiology; D003777:Dental Prophylaxis; D012534:Dental Scaling; D016124:Eikenella corrodens / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007700:Kinetics; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology / Q000628:therapy*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G