In vitro suppression of human lymphocyte activity by minoxidil.
The in vitro effect of minoxidil on normal human lymphocyte activity was studied. At a concentration of 0.1 mg/ml, minoxidil significantly inhibited phytohemagglutinin-dependent lymphocyte DNA synthesis (p less than 0.05), and at 0.01 mg/ml, 0.05 mg/ml, and 0.1 mg/ml, it suppressed mitogen-dependent production of leukocyte migration inhibition factor (p less than 0.04, p less than 0.01, and p less than 0.01, respectively), without compromising cell viability. Minoxidil thus appears to exert a suppressive effect on normal human T-lymphocytes in vitro. The physiologic relevance of these findings remains uncertain.
D002464:Cell Migration Inhibition; D002470:Cell Survival / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000187:drug effects; D008914:Minoxidil / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism
D007961:Leukocyte Migration-Inhibitory Factors; D010835:Phytohemagglutinins; D011743:Pyrimidines; D003208:Concanavalin A; D008914:Minoxidil; D004247:DNA