The influence of cyclosporin on graft and patient survival after renal transplantation. The Groote Schuur Hospital experience.
Fifty pretransfused patients received kidney allografts from brain-dead donors. Cyclosporin was combined with low-dose steroid administration for immunosuppression. Three months after transplantation azathioprine was substituted for the cyclosporin. Patient and graft survival rates were 94% and 88% respectively, with a mean follow-up period of 8 months (range 1-15 months). HLA A, B, C and DR antigens were not considered in the selection of recipients. The ease of use of cyclosporin and its infrequent side-effects are discussed.
D000293:Adolescent; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D016030:Kidney Transplantation; D008875:Middle Aged; D009026:Mortality; D011239:Prednisolone / Q000627:therapeutic use
D003524:Cyclosporins; D011239:Prednisolone; D001379:Azathioprine