(15S)-15-methyl prostaglandin E1-induced neutrophilia in Brown-Norway rats.
A stable analogue of prostaglandin E1, (15S)-15-methyl prostaglandin E1 (M-PGE1), induces a marked relative and absolute neutrophilia after subcutaneous injection at a pharmacologic dose of 1 mg/kg in Brown-Norway rats. The neutrophils reached a peak of 6 hours after injection at which time the absolute neutrophil count was 13,457 +/- 6,038/mm3 versus 2,451 +/- 1,298/mm3 before injection (p less than 0.001). The absolute white blood cell count/mm3 did not change significantly at 6 hours after injection, but a significant eosinopenia was noted, as has been described by previous investigators, after the administration of prostaglandins. A possible physiologic in vivo role for prostaglandin in the causation of neutrophilia remains to be elucidated.
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004804:Eosinophils / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D007964:Leukocytosis / Q000139:chemically induced*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D051381:Rats; D011914:Rats, Inbred BN
C025170:15(S)-15-methylprostaglandin E1; D000527:Alprostadil