title: Cyclic development of immunological memory to bacterial lipopolysaccharide.
abstract: Immunological memory to the lipopolysaccharide of Escherichia coli O113 was generated in strains of inbred mice given a single subimmunogenic dose of either E. coli O113 lipopolysaccharide or the native protoplasmic polysaccharide of E. coli O113. Such memory, which only involved antibody of the immunoglobulin M class, developed in a cyclic manner that was characteristic for the strain of mice used. It involved cell proliferation as well as differentiation and persisted for at least 25 days after priming with a single injection of a subimmunogenic dose of E. coli O113 lipopolysaccharide.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D002455:Cell Division; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D007114:Immunization; D007156:Immunologic Memory; D007700:Kinetics; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D010507:Periodicity; D013045:Species Specificity
chemical_list: D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides