T-cell phenotypes in chemically induced leukemia in mice.
T-cell leukemias were induced in adult BDF mice by a single i.v. injection of 50 mg kg-1 of methylnitrosourea (MNU). Leukemic cells from the thymus and other organ sites showed the theta antigen and were peanut-negative, but were heterogeneous with respect to Lyt-1 and Lyt-2. The acute cytotoxic effect of the MNU showed no preferential toxicity to a special T-cell subset in the thymus. During the latency period of leukemogenesis a continuous fall in peanut-positive cells in the thymus was found.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D037102:Lectins / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008770:Methylnitrosourea; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D019887:Peanut Agglutinin; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects
D000954:Antigens, Surface; D037102:Lectins; D019887:Peanut Agglutinin; D008770:Methylnitrosourea