Beta 2-microglobulin levels in cerebrospinal fluid of children with leukemia and lymphoma.
Beta 2-microglobulin levels were determined in the cerebrospinal fluid (CSF) of 119 children (ages 1 1/2 to 18 years) with malignant conditions; 87 with acute lymphoblastic leukemia, 9 with acute myeloblastic leukemia, 15 with lymphoma, and 8 with solid tumours. A total of 491 CSF specimens and 202 serum specimens were analyzed over a 12-month period. The mean CSF beta 2-microglobulin and serum beta 2-microglobulin were 1.11 +/- 0.58 mg/L and 1.5 +/- 0.64 mg/L respectively and were not different from the mean CSF (1.20 +/- 0.45 mg/L) and serum beta 2-microglobulin levels (1.70 +/- 0.45 mg/L) found in control patients. Meningeal leukemia was diagnosed on the basis of cytology in 7 patients. No elevation of CSF beta 2-microglobulin was found in any specimen at the time of CNS disease. Eleven other patients showed a transient rise in CSF beta 2-microglobulin above the reference range (greater than 2.1 mg/L). No evidence of CNS involvement was found in any of these patients. Five of these patients had received a combination of intrathecal methotrexate and irradiation therapy within the previous 4 months. A transient rise in CSF beta 2-microglobulin (2-3-fold increase over baseline CSF levels), which did not exceed the upper limit of the reference range was seen in 5 of 7 other children receiving the above therapy. Our study fails to demonstrate the usefulness of CSF beta 2-microglobulin for the diagnosis of CNS metastases but suggests that a transient elevation of CSF beta 2-microglobulin may occur after intrathecal methotrexate and irradiation therapy.
D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000134:cerebrospinal fluid*; D008223:Lymphoma / Q000134:cerebrospinal fluid*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid*
D001613:beta 2-Microglobulin; D008727:Methotrexate