The effects of prostacyclin (PGI2) on haematological and haemodynamic parameters, and lung histology in puppies undergoing cardiopulmonary bypass surgery with profound hypothermia.
Puppies 6-12 kg underwent cardiopulmonary bypass with profound hypothermia. Thirteen animals received 200 ng kg-1 min-1 of PGI2 during bypass whilst 11 control animals received equivalent volumes of glycine buffer (placebo) over a similar period. Results indicated preservation of platelets, leukocytes and fibrinogen levels, together with shortened activated partial thromboplastin times and fewer fibrinogen degradation products post-bypass in PGI2-treated animals. There was an initial fall in blood pressure and systemic vascular resistance in PGI2 treated animals, but pulmonary pressures and resistances, cardiac outputs, and heart rates showed no significant differences from controls. Higher and more satisfactory end of bypass and post-bypass blood pressure levels, together with a lesser fall-off in mean total pulmonary compliance, and shortened bypass times were achieved in treated animals. PGI2 appeared to afford some protection against lung damage as observed by histological studies. All beneficial effects appeared to be significantly greater amongst smaller animals. The results indicate possible benefits from the use of PGI2 in infant open heart surgery.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D007036:Hypothermia, Induced; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D010976:Platelet Count
D005340:Fibrinogen; D011464:Epoprostenol