[Comparative study of the effects of prazosin and atenolol on plasma lipids of hypertensive patients].
In order to investigate comparatively the effects of prazosin and atenolol on plasma lipid concentrations, 60 patients from two centres, presenting with arterial hypertension (diastolic 90-120 mmHg, systolic 160-200 mmHg), were allocated at random to one or the other of these drugs. The lipid profile, stable during the period of observation, included total cholesterol and triglycerides, study by ultracentrifugation, and assays of apoproteins A1 and B by laser immunonephelometry. Determinations were performed 30 days before, and on the 1st, 90 th and 180 th days of treatment. Both drugs had similar lowering effects on blood pressure. A significant decrease in total cholesterol, LDL cholesterol and apoprotein B and an increase in HDL cholesterol and apolipoprotein A1 were observed in patients under prazosin, whereas patients under atenolol exhibited opposite variations in plasma lipids. Although the clinical significance of these findings is uncertain, such metabolic effects should be taken into account when evaluating the risk/benefit ratio of antihypertensive treatments.
D001262:Atenolol / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*
D008055:Lipids; D011799:Quinazolines; D001262:Atenolol; D011224:Prazosin
Etude comparative des effets de la prazosine et de l'aténolol sur les lipides plasmatiques de patients hypertendus.