title: Properties of a respiratory syncytial virus isolated from a sheep with rhinitis.
abstract: A virus isolated from a yearling cross-bred ewe was identified as respiratory syncytial virus (RSV) by indirect immunofluorescence and by virus neutralization with bovine RSV antisera. The virus caused a mild conjunctivitis in 3-month-old lambs when inoculated alone. Although clinical signs of pneumonia were not observed, there was gross and microscopic evidence of pulmonary inflammation in the lungs of lambs inoculated with either the sheep RSV isolate alone or in conjunction with Pasteurella haemolytica. Lung lesions in the dual infection were more severe, with approximately 10% of the total lung mass affected. Lavage fluids from lambs inoculated with virus and bacteria contained approximately 3 times more inflammatory cells than from control lambs or lambs inoculated with virus only. The sheep RSV isolate was classified as a mild respiratory pathogen in lambs of this age. Speculations on the potential importance of this virus in interspecies transmission to cattle and goats were discussed.
mesh_terms: D000818:Animals; D002831:Choroid Plexus; D003231:Conjunctivitis / Q000662:veterinary; D046508:Culture Techniques; D005260:Female; D005455:Fluorescent Antibody Technique; D008168:Lung / Q000473:pathology; D010326:Pasteurella Infections / Q000473:pathology / Q000662:veterinary; D011014:Pneumonia / Q000662:veterinary; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification / Q000472:pathogenicity*; D010253:Respirovirus Infections / Q000473:pathology / Q000662:veterinary; D012220:Rhinitis / Q000382:microbiology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology* / Q000473:pathology