Pharmacological studies of furo [3,2-b]indole derivatives. II. Analgesic effect of FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo[3,2-b]ind ole-2-carboxamide, in experimental animals.
FI-302, N-(3-piperidinopropyl)-4-methyl-6-trifluoromethyl-furo[3,2-b]indol e-2-carboxamide, is a new non-steroidal anti-inflammatory compound. The analgesic effect of FI-302 was investigated in comparison with those of non-steroidal anti-inflammatory drugs (NSAIDs). In the tail pressure, hot plate and D'Amour and Smith methods, FI-302 showed a potent analgesic effect, its efficacy being about 2 to 7 times greater than those of aminopyrine, mepirizole and tiaramide. On the other hand, in these methods, aspirin, ibuprofen and phenylbutazone had little or no effect. FI-302 showed a potent inhibitory effect on the vocalization response produced by electrical stimulation. Moreover, the analgesic effect of FI-302 after intracerebroventricular injection was about 58 to 278 times more potent than those of tiaramide and ibuprofen, and about 1/6 that of morphine. However, the analgesic effect of FI-302 was not antagonized by levallorphan. From these results, it appears that FI-302 has potent analgesic effects which may be produced by both peripheral and central mechanisms, but it is a non-narcotic compound. Consequently, FI-302 should be suitably applicable for clinical purposes.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004558:Electric Stimulation; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D014828:Vocalization, Animal / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007211:Indoles; C046922:FI 302