Effects of manganese chloride on the outward currents in frog atrial trabeculae.
The effects of MnCl2 on outward currents in frog atrial muscle were investigated under voltage-clamp conditions. MnCl2 (3 mmol/L), which completely abolished the slow inward current, produced a decrease in the outward background current (Ib) at potentials positive to -50 mV. The delayed outward current (Ix, time dependent) was not altered by Mn. "Isochronic activation curves" for Ix and decay of current tails at -40 mV remained unaffected after Mn. Effects on Ib probably reflect a decrease in IK1 related to the decrease in Ca influx as well as a reduction in the Na-Ca exchange current.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D016275:Atrial Function; D002712:Chlorides; D006321:Heart / Q000502:physiology*; D006325:Heart Atria / Q000187:drug effects; D007700:Kinetics; D008345:Manganese / Q000494:pharmacology*; D017895:Manganese Compounds; D008564:Membrane Potentials / Q000187:drug effects; D011892:Rana catesbeiana
D002712:Chlorides; D017895:Manganese Compounds; D008345:Manganese; C025340:manganese chloride