Pharmacokinetic factors as causes of variability in response to non-steroidal anti-inflammatory drugs.
Even the most widely used non-steroidal anti-inflammatory drugs (NSAID's) show considerable variations in their pharmacokinetic behaviour in volunteers and moreso in patients. An evaluation of the response-related pharmacokinetic parameters of the three presently most widely used NSAID's, namely diclofenac, indomethacin and piroxicam shows some obvious reasons: While the onset of absorption and the bioavailability of diclofenac varies considerably, we find relevant differences in the terminal plasma half-life of indomethacin and particularly piroxicam. Inter-patient variability in these parameters may contribute significantly to the observed variations in clinical response.
D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000627:therapeutic use; D001646:Bile / Q000378:metabolism; D001682:Biological Availability; D004008:Diclofenac / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000378:metabolism; D007700:Kinetics; D008102:Liver Circulation; D008657:Metabolic Clearance Rate; D010894:Piroxicam; D012216:Rheumatic Diseases / Q000188:drug therapy; D013843:Thiazines / Q000378:metabolism; D014018:Tissue Distribution
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; D004008:Diclofenac; D007213:Indomethacin