Effect of phosphonic analogues of glutamic acid on glutamate decarboxylase.
Among the phosphonic analogues of glutamic acid, only 4-amino-4-phosphono butyric acid, the compound which shows the highest affinity for pyridoxal phosphate, inhibits competitively both Escherichia coli and rat brain glutamate decarboxylases. Phosphinothricin, 2-amino-4-(methylphosphino)butyric acid, is a strong inhibitor of the mammalian enzyme.
D000818:Animals; D001921:Brain / Q000201:enzymology; D004926:Escherichia coli / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000037:antagonists & inhibitors*; D005971:Glutamates / Q000494:pharmacology*; D007700:Kinetics; D063065:Organophosphonates / Q000494:pharmacology*; D011732:Pyridoxal Phosphate / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
D005971:Glutamates; D063065:Organophosphonates; D011732:Pyridoxal Phosphate; D005968:Glutamate Decarboxylase