[Changes in the lactate dehydrogenase isoenzyme spectrum during T-lymphocyte differentiation].
The pattern of lactate dehydrogenase isoenzyme spectrum changes on different stages of T-lymphocyte differentiation was studied An enriched population of stem cells has LDH-5, 4 and 3 isoenzymes, and much less LDH-2 activity. The isoenzyme pattern of thymic cell precursors consists of LDH-5, 4, 3 and 2. All the five LDH isoenzymes were found in cortical thymocytes. Medullary thymocytes reveal LDH-5, 4 and 3 isoenzymes. T-lymphocytes of peripheral lymphoid organs contain mainly LDH-5 and in a lesser degree LDH-4 activity.
D000818:Animals; D002454:Cell Differentiation; D004622:Embryo, Mammalian; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000166:cytology* / Q000201:enzymology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Izmenenie spektra izofermentov laktatdegidrogenazy v protsesse dfferentsirovki T-limfotsitov.