Lymphokine-induced phagocytosis in angiocentric immunoproliferative lesions (AIL) and malignant lymphoma arising in AIL.
A factor that augmented the phagocytosis of IgG-coated ox red blood cells by the human monocyte/macrophage line U937 was identified in cell culture supernatants from two of two patients with angiocentric peripheral T cell lymphomas, three of three patients with angiocentric immunoproliferative lesions that were not frankly malignant, and one of two patients with T lymphoblastic malignancies. The factor was not present in supernatants derived from 14 nonangiocentric peripheral T cell lymphomas of other histologic types nor in ten cases of B cell lymphoma and two cases of Hodgkin's disease. A similar factor was present in the supernatants of concanavalin A (Con A)-stimulated normal peripheral blood mononuclear cells and in the supernatants of IL-2-dependent T cell lines derived from normal peripheral blood. The factor had an apparent mol wt of greater than 50,000 daltons, was heat labile (100 degrees C for two minutes), and stable at pH 2.0. Its stimulation of phagocytosis was independent of any increase in number of Fc receptors. Thus, this factor is probably not gamma-interferon. This factor may play a pathogenetic role in the hemophagocytic syndromes associated with certain T cell malignancies and immunodeficient states.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008222:Lymphokines / Q000502:physiology*; D008223:Lymphoma / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology*; D008264:Macrophages; D009000:Monocytes; D010587:Phagocytosis; D011961:Receptors, Fc / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007074:Immunoglobulin G; D008222:Lymphokines; D011961:Receptors, Fc