title: Diuretics and calcium metabolism.
abstract: In this review the normal renal tubular handling of calcium is briefly described. A detailed examination follows of the sites and modes of action of furosemide and thiazide diuretics on renal calcium handling and overall calcium metabolism. The clinical applications of these effects are also considered. Finally, the use of diuretics with different tubular sites of action on calcium transport as probes to study disorders of calcium excretion is discussed.
mesh_terms: D000042:Absorption; D000086:Acetazolamide / Q000494:pharmacology; D000328:Adult; D000818:Animals; D001581:Benzothiadiazines; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004232:Diuretics; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy; D007684:Kidney Tubules / Q000378:metabolism*; D008138:Loop of Henle / Q000378:metabolism; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D005665:Furosemide; D000086:Acetazolamide; D002118:Calcium