[Synthesis and pharmacologic activity of new derivatives of salicylic acid].
New 1-phenyl-2-R2-3-methyl-5-salicyloylimmino-3-pyrazolines were synthesized according to a previously described route. The obtained pyrazoline derivatives, together with some others reported in previous papers, were tested for analgesic and antiinflammatory activities. Some derivatives showed analgesic and/or antiinflammatory activity similar to that of acetylsalicylic acid.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D002351:Carrageenan
Sintesi ed attività farmacologica di nuovi derivati dell'acido salicilico.