Temperature dependent modification of radiosensitivity following hypoxic cytocidal action of chlorpromazine.
The hypoxic cytotoxic effect of chlorpromazine towards E. coli B/r was observed to be dependent on temperature of incubation and irradiation. Increasing the temperature of incubation from ambient to 37 degrees C followed by irradiation revealed that the organisms showed radiosensitivity of a magnitude which was two to three times the oxygen effect. The possible mechanisms of this effect are discussed.
D002746:Chlorpromazine / Q000494:pharmacology*; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D010100:Oxygen / Q000502:physiology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013696:Temperature
D003037:Cobalt Radioisotopes; D011838:Radiation-Sensitizing Agents; D010100:Oxygen; D002746:Chlorpromazine