[Effect of thrombin and prostaglandins E and F on various indices of carbohydrate metabolism in human platelets].
After incubation of intact thrombocytes with prostaglandins E2 and F2 alpha stimulation of glucose-6-phosphate dehydrogenase and glutathione reductase activities as well as an increase in the rate of sedoheptulose-7-phosphate accumulation were found. Thrombin inhibited the glucose-6-phosphate dehydrogenase activity by 30% in these thrombocytes. Addition of thrombin, following the incubation of thrombocytes with prostaglandins, removed the activating effect of the prostaglandins on the pentosephosphate pathway reactions, inhibited glutathione reductase and lactate dehydrogenase.
D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D015237:Dinoprost; D015232:Dinoprostone; D006801:Humans; D066298:In Vitro Techniques; D010084:Oxidation-Reduction; D010427:Pentose Phosphate Pathway; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology*
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D013917:Thrombin; D015232:Dinoprostone
Vliianie trombina i prostaglandinov seriĭ E i F na nekotorye reaktsii uglevodnogo obmena v trombotsitakh cheloveka.