[Effect of tilorone on the immunological indices of guinea pigs with synestrol-induced glandular hyperplasia of the endometrium].
The immune system state was studied before and after administration of tilorone (an immunologic adjuvant) to guinea pigs with synestrol-induced glandular hyperplasia of endometrium. The total amount of T- and B-lymphocytes. T-lymphocytes with receptors to the Fc-fragment of IgM and IgG, the content of immune complexes were determined. Immune and nonimmune adherence of neutrophils was investigated as well. It was established that the total amount of T-lymphocytes decreased and the quantity of T-lymphocytes and immune complexes increased with the development of glandular hyperplasia of the endometrium. The tilorone administration normalized the structure of endometrium and T-lymphocyte immune controlling system.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004028:Dienestrol / Q000633:toxicity*; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D006168:Guinea Pigs; D010636:Phenols / Q000633:toxicity*; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013994:Tilorone / Q000627:therapeutic use*
D000936:Antigen-Antibody Complex; D005449:Fluorenes; D010636:Phenols; D011961:Receptors, Fc; D013994:Tilorone; D004028:Dienestrol
Vliianie tilorona na nekotorye immunologicheskie pokazateli u morskikh svinok s zhelezistoĭ giperplazieĭ éndometriia, indutsirovannoĭ sinéstrolom.