Cell kinetic studies of the effect of cytotoxic drugs on survival and proliferation of ascites and solid tumor cells of the mouse.
The three studies discussed show that the response of experimental ascites and solid tumors, as well as of the host organism, to a cytotoxic drug can be studied quantitatively with cell kinetic methods. Knowledge of this kind is necessary in the attempt to improve the application of cytotoxic drugs in chemotherapy of tumors which up to now has been based mainly on pure empiricism.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D001201:Ascites / Q000473:pathology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D003561:Cytarabine / Q000494:pharmacology* / Q000627:therapeutic use; D007399:Interphase; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*
D003561:Cytarabine; D003520:Cyclophosphamide