HLA-DR antigens in Chinese children with insulin-dependent diabetes mellitus.
We studied the distribution of HLA-DR and MT1, MT2, MT3 genotypes in 23 Chinese children with insulin-dependent diabetes mellitus (IDDM). The frequency of DR3 was 48% in IDDM children compared to 14% of normal controls (corrected p = 0.0098, RR = 5.70). The frequency of DR4 was not increased. These differences when compared with the results of Western populations may contribute to the relative rarity of IDDM among Chinese children.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D012846:Singapore
D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II