Normalization of urinary oxalate by taurine in glycolate-fed rats.
Oral feeding of sodium glycolate (50 mg/d/rat for ten days) caused a significant (P less than 0.001) increase in oxalate and taurine excretion and a decrease in liver protein content (P less than 0.05), glycolic acid oxidase levels (P less than 0.01), and glycolic acid dehydrogenase levels (P less than 0.01) as compared to normal untreated rats. Taurine (100 mg/d/rat), when administered along with glycolate, prevented these effects of glycolate as evident from normal urinary excretion of oxalate, liver protein content, glycolic acid oxidase, and glycolic acid dehydrogenase levels in glycolate- plus taurine-fed animals.
D000429:Alcohol Oxidoreductases / Q000032:analysis; D000818:Animals; D006016:Glycolates / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D010070:Oxalates / Q000378:metabolism* / Q000652:urine; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology* / Q000652:urine
D006016:Glycolates; D010070:Oxalates; D011506:Proteins; D013654:Taurine; D000429:Alcohol Oxidoreductases; C020819:glycolic acid dehydrogenase; D007770:L-Lactate Dehydrogenase; C020821:glycollate oxidase