Activity increases quantal size at the frog neuromuscular junction.
Two h of nerve stimulation at 10 Hz or of elevated spontaneous release in hypertonic solution increased the size of miniature end-plate potentials (m.e.p.p.'s) and currents at the frog neuromuscular junction, probably by increasing the amount of acetylcholine in a quantum. Increases in quantal size may modulate synaptic transmission.
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D006982:Hypertonic Solutions; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D011894:Rana pipiens
D006982:Hypertonic Solutions; D000109:Acetylcholine