Verapamil induces glucose intolerance in conscious, nondiabetic rats.
Intravenous verapamil administration in normal rats significantly impaired the rats' ability to respond to a glucose tolerance test, and blocked the glucose-stimulated release of insulin into the blood. The results suggest that verapamil can impair pancreatic endocrine function in vivo.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D014700:Verapamil