The role of the small intestine in cystic fibrosis patients.
A survey is given of the morphological and biochemical lesions of the small intestine that can be found in cystic fibrosis patients. The available data on the structure and function of the small intestine in CF patients favour the hypothesis that the small intestine itself might contribute to the malabsorption of nutrients in this disease. The most pronounced lesions, i.e. meconium ileus and absent active transport of bile salts are found in the ileum. It might be remembered that the ileum is also the site of intensive exchange of chloride and bicarbonate, a function that is heavily disturbed in the pancreas of CF patients. For this reason, further studies on the ileal function in cystic fibrosis are warranted.
D001639:Bicarbonates / Q000378:metabolism; D001706:Biopsy; D002648:Child; D002712:Chlorides / Q000378:metabolism; D003550:Cystic Fibrosis / Q000503:physiopathology*; D004186:Disaccharidases / Q000032:analysis; D004765:Enteropeptidase / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D006867:Hydrolases / Q000032:analysis; D007421:Intestine, Small / Q000503:physiopathology*; D008470:Meconium / Q000032:analysis / Q000502:physiology; D011506:Proteins / Q000032:analysis
D001639:Bicarbonates; D002712:Chlorides; D005227:Fatty Acids; D011506:Proteins; D006867:Hydrolases; D004186:Disaccharidases; D004765:Enteropeptidase