Immunological dysfunction in Alzheimer's disease.
Peripheral blood lymphocytes from Alzheimer's patients and apparently healthy elderly individuals were examined for interleukin-1 (IL-1) production. Our results indicate severely low production of IL-1 by patient's peripheral blood monocytes. The low production of IL-1 in vitro correlated with patients' symptoms and therapy with 1-acetamide,2-pyrrolidone (1a,2p). In addition to low IL-1 production, the number of autologous rosette forming cells (ARFC) was significantly decreased in all Alzheimer's patients whereas B-cell glucose metabolism was significantly higher than age-matched healthy individuals.
D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D003847:Deoxyglucose / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation
D007375:Interleukin-1; D003847:Deoxyglucose; D005947:Glucose