Hemodynamic measurements in a sheep model with a hollow fiber artificial kidney containing modified cellulose.
HFAK-RC caused pronounced leukopenia, increase in TXB2 levels in plasma and hemodynamic pressure changes as a reflection of complement activation during EC in sheep. In contrast no increase in TXB2 levels and no changes in hemodynamics are observed with HFAK-MC. The leukopenia and granulocytopenia in the latter is much less pronounced and probably reflects the phenomenon "frustrated phagocytosis".
D000818:Animals; D001794:Blood Pressure; D002482:Cellulose; D003167:Complement Activation; D006439:Hemodynamics; D007688:Kidneys, Artificial / Q000009:adverse effects*; D007970:Leukopenia / Q000209:etiology; D012756:Sheep; D013929:Thromboxane B2 / Q000097:blood
D013929:Thromboxane B2; D002482:Cellulose