The pharmacokinetics of cimetidine and metabolites in a neonate.
Limited pharmacokinetic data have been reported concerning the use of cimetidine in the neonate for the management of gastrointestinal hemorrhage. After receiving cimetidine at a dose of 10 mg/kg/d in a full-term infant, the steady-state peak and four-hour concentrations were 3.5 and 1.8 micrograms/ml, respectively. A mean half-life of 3.6 h for cimetidine and 2.2 h for cimetidine sulfoxide were determined. The cimetidine half-life was prolonged, and the total body clearance decreased as compared with values reported in critically ill children and adults.
D001711:Biotransformation; D002927:Cimetidine / Q000378:metabolism* / Q000627:therapeutic use; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008297:Male; D013290:Streptococcal Infections / Q000150:complications; D013292:Streptococcus agalactiae
D002927:Cimetidine