Biosynthetic human EGF accelerates healing of Neodecadron-treated primate corneas.
Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epithelial cells of EGF-Neodecadron-treated corneas appeared normal on histologic examination and showed no evidence of hypertrophy or hyperplasia. The EGF-Neodecadron-treated stromal incisions were characterized by new collagen formation and a smaller epithelial cell plug than Neodecadron-treated control corneas. These results suggest that biosynthetic h-EGF, which lacks the immunologic potential of nonhuman proteins, may be effective in accelerating healing of corneal epithelial defects and stromal incisions in patients whose healing is suppressed by treatment with steroids.
D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000502:physiology; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D008252:Macaca fascicularis; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012038:Regeneration / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; C004180:dexamethasone 21-phosphate; D004815:Epidermal Growth Factor; D003907:Dexamethasone; C009935:prednisolone acetate; D011239:Prednisolone