title: Primary sclerosing cholangitis.
abstract: Primary sclerosing cholangitis is a chronic, cholestatic disease affecting the biliary tree. Recent data suggest an autoimmune etiology. Clinical findings, roentgenographic characteristics, and compatible liver histology will help in establishing the diagnosis. There is no known treatment for cure, though relief of symptoms may be accomplished with certain drugs, such as antibiotics for cholangitis and cholestyramine for pruritus. Death usually ensues within five to seven years after diagnosis, as a consequence of liver failure, cholangitis, and cholangiocarcinoma.
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000502:physiology; D001659:Biliary Tract / Q000473:pathology*; D002648:Child; D002761:Cholangitis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012598:Sclerosis
chemical_list: D000936:Antigen-Antibody Complex; D006680:HLA Antigens