Cerebral blood flow autoregulation and hypertension.
Hypertension and antihypertensive therapy have clinically important effects on cerebral blood flow. The autoregulatory changes that occur with chronic arterial hypertension should influence the clinician's choice of antihypertensive agents and the rapidity with which the blood pressure is lowered in order to avoid symptoms of focal or global cerebral hypoperfusion.
D000368:Aged; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001927:Brain Diseases / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002908:Chronic Disease; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D006974:Hypertension, Malignant / Q000209:etiology / Q000503:physiopathology; D007427:Intracranial Pressure / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010215:Papio; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D009599:Nitroprusside; D009543:Nifedipine