Proliferative response of human lymphocytes to secretory and cellular antigens of Trichomonas vaginalis.
Lymphocytes from patients with active trichomoniasis showed a proliferative response when incubated in the presence of secretory and cellular products of either pathogenic or non-pathogenic Trichomonas vaginalis. Maximal responses were detected using 50 micrograms per ml protein after 5 days incubation. Lymphocytes from non-infected laboratory workers showed no response to these antigens. This indicates that delayed hypersensitivity reactions may act to modulate inflammatory responses in trichomoniasis.
D000953:Antigens, Protozoan / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014247:Trichomonas Vaginitis / Q000276:immunology*; D014246:Trichomonas vaginalis / Q000276:immunology* / Q000472:pathogenicity
D000953:Antigens, Protozoan; D010835:Phytohemagglutinins; D013936:Thymidine