Toxicology of 85Kr: effects of whole-body immersion exposure on newborn rats.
Newborn rats exposed to 85Kr exhibited acute radiation effects, e.g. epilation, skin scaling and abnormal development of the extremities, at beta immersion doses in excess of 1000 rad to the skin surface. The incidence of skin tumors, principally basal-cell carcinomas, was increased at all dose levels over the range from 1000 to 4750 rad. The effective skin-surface dose to induce basal-cell carcinoma in the newborn Wistar rat is apparently less than 1000 rad, the lowest dose employed in this study. No lung tumors attributable to 85Kr exposure were observed in these rats.
D000818:Animals; D000831:Animals, Newborn; D001610:Beta Particles; D002280:Basal Cell Carcinoma / Q000209:etiology; D005260:Female; D007726:Krypton; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011833:Radiation Injuries, Experimental / Q000401:mortality; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012878:Skin Neoplasms / Q000209:etiology; D013793:Thallium; D014916:Whole-Body Irradiation
D011868:Radioisotopes; D007726:Krypton; D013793:Thallium