title: [Comparison between cimetidine-pirenzepine and antacids for the prevention of stress hemorrhage in intensive care patients. A controlled clinical study on 125 patients].
abstract: In a controlled clinical trial, the efficacy of an intravenous combination of cimetidine and pirenzepine (group A: 62 patients) was compared with that of an intragastric administration of a magnesium-aluminium-hydroxide concentrate (group B: 58 patients) in preventing visible and occult upper gastrointestinal tract bleeding in intensive-care patients. It was found that both forms of therapy had the same favourable effect on the extent and incidence rate of visible and occult gastric bleeding. The antacid was more effective than the cimetidine-pirenzepine combination in raising the pH level to 4 or higher (P less than 0.05). Intensive-care patients should, therefore, be treated with the antacid whenever possible, since it is equally effective as the cimetidine-pirenzepine combination in preventing bleeding from the upper gastrointestinal tract, whereas it is superior in elevating the gastric pH. Besides, the use of the antacid is also less costly.
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002860:Chromium Radioisotopes; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003128:Coma / Q000150:complications; D004338:Drug Combinations; D005260:Female; D005750:Gastric Juice / Q000032:analysis; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control*; D006138:Guaiac; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D009780:Occult Blood; D010890:Pirenzepine; D012131:Respiratory Insufficiency / Q000150:complications
chemical_list: D000863:Antacids; D001570:Benzodiazepinones; D002860:Chromium Radioisotopes; D004338:Drug Combinations; D010890:Pirenzepine; D002927:Cimetidine; D006138:Guaiac
vernacular_title: Vergleich von Cimetidin-Pirenzepin und Antacida zur Stressblutungsprophylaxe bei Intensivpatienten. Eine kontrollierte klinische Studie an 120 Patienten.