title: The effects of premedication on anaesthesia with propofol ('Diprivan').
abstract: The effects of premedication on anaesthesia with propofol (2,6-diisopropylphenol) in a dose of 2.5 mg/kg were assessed. One hundred and twenty female patients were randomized into one of three groups of 40 who received either no premedication, diazepam 10 mg orally, or pethidine 50-75 mg intramuscularly (i.m.) and atropine 0.6 mg i.m. Propofol 2.5 mg/kg was found to be a reliable induction dose. Premedication did not affect the induction time nor the incidence of side effects which occurred in 19% of patients. Apnoea occurred in 44% of patients but was not related to premedication, nor was arterial hypotension. Pain on injection was rare in the antecubital fossa but was a frequent occurrence (30%) in the dorsum of the hand. Recovery was rapid and characterized by lack of emetic sequelae; only one patient had nausea and there was no vomiting. The site of injection was examined postoperatively and venous sequelae were rare.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001049:Apnea / Q000139:chemically induced; D001285:Atropine / Q000009:adverse effects / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008614:Meperidine / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010636:Phenols; D011229:Preanesthetic Medication; D015742:Propofol; D011897:Random Allocation
chemical_list: D010636:Phenols; D001285:Atropine; D008614:Meperidine; D003975:Diazepam; D015742:Propofol