[Anti-bacterial effect of ofloxacin--in vitro and in vivo results].
Gram (-) bacteria such as E. coli, B. proteus, Klebsiella and Pseudomonas sp were found to be sensitive to Ofloxacin 98.3%, 96.7%, 96.9%, and 89.1% respectively. Among Gram (+) bacteria, 98% of Staph aureus and 95% of Staph epidermidis were susceptible to this drug. The minimum inhibitory concentrations of Ofloxacin for the Shigella strains have been found to be between 0.1-0.05 mcg/ml (76%) and 0.05-0.025 mcg/ml (20%). Thirty three patients with various infection have been treated with ofloxacin; in acute cases the efficacy of the drug was 100%, but reinfections or relapse developed in about half of the patients with chronic and complicated urinary tract infections, 15-20 days after discontinuation of the drug. No serious side effect has been observed.
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology* / Q000627:therapeutic use; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014552:Urinary Tract Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D010078:Oxazines; D015242:Ofloxacin
Ofloxacin'in antibakteriyel etkisi - in vitro ve in vivo sonuçlar.