Relationship between postvaccinal anti-influenza antibodies, blood magnesium levels, and HLA antigens.
Seventy-eight healthy subjects belonging to 16 different families were submitted to an anti-influenza vaccination. The antibody titers and the red blood cell and plasma Mg concentrations were determined before and 30 days after vaccination. The population study performed on 32 subjects showed the occurrence of a higher antibody response (P less than 0.01) and a lower red blood cell Mg level, among the Bw35 individuals. These findings are confirmed by family studies: HLA identical sibs have values much closer to those of the propositi than to those of the HLA different sibs. The relationships between HLA, immune response, and Mg revealed by the present investigation are discussed in light of the literature together with the known associations between HLA Bw35 antigen and diseases.
D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D002648:Child; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015797:HLA-B35 Antigen; D006801:Humans; D007114:Immunization; D008274:Magnesium / Q000097:blood*; D008297:Male; D009975:Orthomyxoviridae / Q000276:immunology; D012737:Sex Factors; D013223:Statistics as Topic
D000914:Antibodies, Viral; D006680:HLA Antigens; D015797:HLA-B35 Antigen; D008274:Magnesium