Effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunotoxicity.
Radiothyroidectomy protected against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in rats as assessed by the spleen anti-SRBC plaque-forming cell assay. Thyroxine (T4) replacement therapy partially reversed the effects of thyroidectomy on T4 and triiodothyronine (T3) serum levels, body weight and immune function as well as restored TCDD-induced immunotoxicity. Thus, hypothyroidism induced by TCDD exposure can be viewed as a protective response of the organism to reduce the insult caused by TCDD.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004147:Dioxins / Q000633:toxicity*; D006462:Hemolytic Plaque Technique; D007121:Immunocompetence / Q000187:drug effects; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000187:drug effects; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D014284:Triiodothyronine; D013974:Thyroxine