An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells.
In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecules to present antigen to Ia-restricted antigen-specific T cells.
D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002999:Clone Cells; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000235:genetics; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*; D014158:Transcription, Genetic
D000949:Histocompatibility Antigens Class II; D012333:RNA, Messenger