title: [Measurement of inner ear circulation using radioactive indicators].
abstract: To clarify the possibility of measuring the inner ear blood flow by radionuclide imaging, we used a skull phantom and a scintillation camera and found that a concentration difference of at least 100: 1 between the inner ear and the background is needed for external detection. Similar concentration differences can be found in aminoglycosid antibiotics because of their special pharmacokinetic characteristics. We believe, therefore, that with an appropriate radioactive indicator, such as labelled aminoglycoside or labelled (99mTc, 123J)-inulin, it would be possible to measure the inner ear blood flow in a non-invasive and selective way.
mesh_terms: D007758:Ear, Inner / Q000098:blood supply*; D006801:Humans; D008953:Models, Anatomic; D011865:Radioisotope Dilution Technique; D012039:Regional Blood Flow; D013667:Technetium
chemical_list: D013667:Technetium
vernacular_title: Untersuchungen zur Messbarkeit der Innenohrdurchblutung mittels radioaktiven Indikators.