Peripheral blood and CSF T-cell subsets in Japanese MS patients.
We analyzed peripheral blood and CSF T-cell subsets in Japanese patients with MS, using an OK series of monoclonal antibodies in an immunofluorescent technique. In the peripheral blood, suppressor T cells were increased, with a concomitant decrease in helper T cells, after recovery from acute exacerbation, but there was no relationship between T cells in peripheral blood and CSF. In the CSF, acute exacerbation was associated with an increase in Ia-positive cells and a decrease in T cells. CSF pleocytosis (with more than 30% of Ia-positive cells) probably indicated active disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid; D013601:T-Lymphocytes / Q000032:analysis* / Q000145:classification