Hypotensive effect in the rat after oral prostacyclin (PGI2).
PGI2 dose dependently lowers mean systemic arterial pressure in conscious normotensive and spontaneously hypertensive rats after oral administration. The ED30 was respectively 0.79 and 0.63 mg/kg. Heart rate was not significantly modified. The hypotensive effect appears to be due to PGI2 itself and not to its metabolite 6-keto-PGF1 alpha which, administered at 2 mg/kg p.o., did not modify blood pressure.
D015121:6-Ketoprostaglandin F1 alpha / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D011464:Epoprostenol / Q000494:pharmacology*; D008297:Male; D051379:Mice
D000959:Antihypertensive Agents; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol