Inhibition of NK cell-induced cytolysis by thiocarbamide antithyroid drugs.
The thiocarbamide antithyroid drugs, methimazole and propylthiouracil, suppressed natural killer (NK) cell-induced cytolysis in vitro (determined by the release of 51Cr-chromate from labelled target cells) in a dose-dependent manner. Parallel experiments demonstrated a similar reduction in NK cell luminol chemiluminescence during activation by K562 tumour cells. It would appear, therefore, that an association may exist between NK cell-induced cytolysis and the peroxidase/oxygenase activity of these lymphocytes.
D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D008163:Luminescent Measurements; D008165:Luminol; D008713:Methimazole / Q000494:pharmacology*; D010105:Oxygenases / Q000037:antagonists & inhibitors; D010544:Peroxidases / Q000037:antagonists & inhibitors; D011441:Propylthiouracil / Q000494:pharmacology*
D008713:Methimazole; D008165:Luminol; D011441:Propylthiouracil; D010544:Peroxidases; D010105:Oxygenases