HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics.
A series of diabetic patients from 3 centres in South India have been tested for HLA A, HLA B, BF, C2, C4A, C4B and GLO types. For insulin-dependent diabetes mellitus (IDDM) patients there was a significant increase in HLA B8, of BF F and decrease of C4 A6. No significant variation in HLA, BF, C2 or GLO frequencies was found in non-insulin-dependent diabetes mellitus (NIDDM) patients, but there was a significant decrease in C4B 1 and an increase in C4B 2. The HLA and BF association in South Indian IDDM patients is very different from that reported previously in North India.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002906:Chromosomes, Human, 6-12 and X; D003175:Complement C2 / Q000032:analysis* / Q000235:genetics; D003181:Complement C4 / Q000032:analysis* / Q000235:genetics; D015934:Complement C4a; D015935:Complement C4b; D011415:Complement Factor B / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D004792:Enzyme Precursors / Q000235:genetics*; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D010641:Phenotype
D003175:Complement C2; D003181:Complement C4; D004792:Enzyme Precursors; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015934:Complement C4a; D015935:Complement C4b; D011415:Complement Factor B; D008190:Lyases; D007791:Lactoylglutathione Lyase