Effect of preoperative cimetidine and ranitidine on gastric secretion.
To decrease gastric volume and acidity prior to anesthesia and surgery and decrease the risk of aspiration, a prospective double-blind trial comparing two H2 receptor blockers, cimetidine and ranitidine, was performed. Analysis of gastric contents revealed both drugs to be extremely effective in raising gastric pH to the 6-7 range. However, ranitidine was shown to be more effective in decreasing gastric volume.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*
D002927:Cimetidine; D011899:Ranitidine