Two types of inflammatory vascular disease in Sjögren's syndrome. Differential association with seroreactivity to rheumatoid factor and antibodies to Ro (SS-A) and with hypocomplementemia.
Two types of inflammatory vascular disease (IVD) occur in Sjögren's syndrome: neutrophilic IVD (NIVD) and mononuclear IVD (MIVD). In 45 patients with Sjögren's syndrome, we examined the 2 types of IVD with respect to serologic associations. NIVD, unlike MIVD, was significantly associated with seroreactivity reflected by hyperglobulinemia (P = 0.01), rheumatoid factor (P = 0.002), antinuclear antibodies (P = 0.02), and antibodies to Ro (SS-A) (P = 0.00006), and with hypocomplementemia (P = 0.03). The differential association of the 2 types of IVD with serologic reactivity and hypocomplementemia suggests that there may be basic differences in the immunopathogenesis of these 2 forms of IVD in Sjögren's syndrome.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D000974:Antibodies, Antinuclear / Q000032:analysis; D001158:Arteries / Q000166:cytology; D001167:Arteritis / Q000145:classification / Q000150:complications*; D001324:Autoantigens / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011693:Purpura / Q000209:etiology; D020733:RNA, Small Cytoplasmic; D012217:Rheumatoid Factor / Q000032:analysis; D012261:Ribonucleoproteins; D012859:Sjogren's Syndrome / Q000150:complications / Q000473:pathology*; D000099207:SS-A Antigen
D000906:Antibodies; D000974:Antibodies, Antinuclear; D001324:Autoantigens; D003176:Complement C3; D003181:Complement C4; D020733:RNA, Small Cytoplasmic; D012217:Rheumatoid Factor; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human