title: Plasma concentrations of thyroid hormones in dogs: influence of sampling hour, breed and age.
abstract: Thyroxine (T4) and triiodothyronine (T3) plasma concentrations have been determined during 24-hr sampling periods in six mongrels (age 12-36 months), six beagles (age 35-37 months), three labradors (age 3.5 months) and three beagles (age 5 months). The mean T4 levels of the labradors were significantly lower than the values found for mongrels or older beagles (P less than 0.05), whereas T3 was higher in the 5 month old beagles compared to the mongrels (P less than 0.001), young beagles (P less than 0.05) or labradors (P less than 0.01). Circadian and ultradian rhythmicities have been evaluated by cosinor and Fourier analysis. Mongrels and older beagles did have a 12-hr rhythmicity in plasma T4 (P less than 0.05), whereas 5 month old beagles had a circadian one (P less than 0.01). A 12-hr rhythmicity was also found for T3 in the older Beagles (P less than 0.05). However, Fourier analysis indicated that the daily variation in T4 and T3 plasma levels was inadequately mathematically described by single sinusoidal rhythm and that more harmonic components are to be taken into account. The obtained data during a 24-hr period indicate that T4 and T3 concentrations in plasma may vary according to breed, age and sampling hour.
mesh_terms: D000375:Aging / Q000097:blood / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm; D004285:Dogs / Q000097:blood / Q000502:physiology*; D005260:Female; D013045:Species Specificity; D013963:Thyroid Hormones / Q000097:blood / Q000502:physiology*
chemical_list: D013963:Thyroid Hormones