Sequence of the OXA2 beta-lactamase: comparison with other penicillin-reactive enzymes.
The nucleotide sequence of the unusual plasmid-mediated OXA2 beta-lactamase is presented, and compared with other beta-lactamases. The OXA2 enzyme has similar features at the presumed active site, but no other significant regions of homology with other penicillin-reactive enzymes. The active site homology may therefore represent convergent evolution of otherwise dissimilar genes.
D000596:Amino Acids / Q000032:analysis; D001483:Base Sequence; D010406:Penicillins / Q000378:metabolism*; D001618:beta-Lactamases / Q000032:analysis / Q000235:genetics*
D000596:Amino Acids; D010406:Penicillins; D001618:beta-Lactamases