title: Genotoxic effects of potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate in diploid yeast.
abstract: 4 metal salts, potassium dichromate, sodium arsenite, cobalt chloride and lead nitrate were tested for their genotoxic effects in Saccharomyces cerevisiae. Potassium dichromate was the most potent agent for induction of gene conversion and reverse mutation. Sodium arsenite was virtually ineffective as a convertogen but gave a positive result for reversion. Cobalt chloride was the least toxic, exhibited a convertogenic activity but was only marginally active for reverse mutation. Lead nitrate was the most toxic salt but was genetically inactive.
mesh_terms: D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D002840:Chromates / Q000494:pharmacology*; D003035:Cobalt / Q000494:pharmacology*; D005785:Gene Conversion / Q000187:drug effects; D005800:Genes, Fungal / Q000187:drug effects; D007854:Lead / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009566:Nitrates / Q000494:pharmacology*; D011192:Potassium Dichromate / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D017670:Sodium Compounds
chemical_list: D018053:Arsenites; D002840:Chromates; D009566:Nitrates; D017670:Sodium Compounds; D007854:Lead; D003035:Cobalt; C017947:sodium arsenite; C017461:lead nitrate; C018021:cobaltous chloride; D001151:Arsenic; D011192:Potassium Dichromate