The effect of etretinate compared with different regimens of PUVA in the treatment of persistent palmoplantar pustulosis.
Eighty-four patients with persistent palmoplantar pustulosis (PPP) of long duration were treated with either etretinate or one of three PUVA regimens. PUVA was given either with oral methoxsalen (thirteen cases), with a 1% methoxsalen cream (thirty-three cases) or with trioxsalen baths (eighteen cases). Twenty patients were treated with etretinate. Patients were assessed every fourth week. A mean score for each group was calculated at each visit based on erythema, desquamation, induration and pustulation. In addition, the number of pustules was calculated at each visit. After 12 weeks four of twenty-eight patients treated with local methoxsalen and fourteen of seventeen patients treated with etretinate had completely cleared. At this stage no patient treated with local trioxsalen or oral methoxsalen showed complete clearance.
D002908:Chronic Disease; D005050:Etretinate / Q000627:therapeutic use*; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000627:therapeutic use; D008875:Middle Aged; D011701:PUVA Therapy; D010778:Photochemotherapy; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy*; D014307:Trioxsalen / Q000627:therapeutic use
D005050:Etretinate; D008730:Methoxsalen; D014307:Trioxsalen