Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs.
Several antimicrobial agents were evaluated for activity against experimental Legionella micdadei pneumonia in guinea pigs. Erythromycin, rifampin, doxycycline, and sulfamethoxazole-trimethoprim produced significant reductions in mortality. Penicillin, cefazolin, cefoxitin, chloramphenicol, and gentamicin were not efficacious even though, at the doses administered, the peak concentrations of these agents in serum substantially exceeded their MICs for the test strain. It is suggested that the poor performance of the latter group of agents resulted from poor penetration into cells in which L. micdadei was multiplying.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002437:Cefazolin / Q000627:therapeutic use; D002440:Cefoxitin / Q000627:therapeutic use; D002701:Chloramphenicol / Q000627:therapeutic use; D004318:Doxycycline / Q000627:therapeutic use; D004338:Drug Combinations / Q000097:blood / Q000627:therapeutic use; D004917:Erythromycin / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use; D006168:Guinea Pigs; D007700:Kinetics; D007875:Legionella / Q000187:drug effects*; D008297:Male; D010400:Penicillin G / Q000627:therapeutic use; D011014:Pneumonia / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000097:blood / Q000627:therapeutic use*; D014295:Trimethoprim / Q000097:blood / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005839:Gentamicins; D004917:Erythromycin; D002701:Chloramphenicol; D002440:Cefoxitin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D002437:Cefazolin; D013420:Sulfamethoxazole; D004318:Doxycycline; D010400:Penicillin G; D012293:Rifampin