Association of Gaucher's disease and lymphoid malignancy in 2 children.
2 cases of acute lymphoblastic leukaemia (ALL) of childhood in association with Gaucher's Disease (GD) are presented, which are the first to be described. One of them is a common non-B non-T cell ALL and the other is at T-cell ALL. The association of GD with benign and malignant B-cell proliferation has recently been described. It is suggested that chronic stimulation of the immune system by the accumulated glucocerebroside may predispose to B cell proliferation.
D001402:B-Lymphocytes; D002648:Child; D002675:Child, Preschool; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008297:Male; D013601:T-Lymphocytes