A comparison of the antidepressant effects of a synthetic androgen (mesterolone) and amitriptyline in depressed men.
The antidepressant effects of amitriptyline and mesterolone, a synthetic androgen, were compared in a double-blind parallel treatment design. The drugs were equally effective in reducing depressive symptoms. Mesterolone produced significantly fewer adverse side effects than amitriptyline.
D000328:Adult; D000553:Ambulatory Care; D000639:Amitriptyline / Q000009:adverse effects / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D013196:Dihydrotestosterone / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008655:Mesterolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D013196:Dihydrotestosterone; D008655:Mesterolone; D000639:Amitriptyline