title: 'Drug holidays' in the treatment of Parkinson's disease. A brief review.
abstract: "Drug holiday," the withdrawal of levodopa for a variable period of time, is a controversial method of treating patients with Parkinson's disease who have levodopa-related complications. Only four studies have been published in which patients were observed for one year or longer. Although it is extremely beneficial for some patients, this treatment provides a sustained one-year benefit for only a minority of patients.
mesh_terms: D000368:Aged; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006693:Holidays; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D007980:Levodopa