Further studies on the influence of interferon on pokeweed mitogen induced Ig-synthesis in vitro.
Preincubation with pure interferon beta, but not partially purified interferon alpha, increased immunoglobulin production from non-fractionated peripheral blood mononuclear cells stimulated by pokeweed mitogen. Preincubation of B lymphocytes, but not T lymphocytes or monocytes, with pure interferon beta also increased immunoglobulin synthesis. It is concluded that interferon has a direct effect on B lymphocytes in enhancing immunoglobulin production.
D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007370:Interferon Type I / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007370:Interferon Type I; D011043:Pokeweed Mitogens