Eosinophilic granuloma. Presence of OKT6-positive cells and good response to intralesional steroid.
A patient with eosinophilic granuloma, with extensive oral mucous membrane involvement, was treated with intralesional triamcinolone acetonide injections. Although radiation therapy had failed, this treatment resulted in remission. The biopsy specimen from the patient's lesion contained a predominance of OKT6-positive cells, which were shown by electron microscopic analysis to be mostly indeterminate cells and a small percentage of Langerhans' cells, with characteristic L-cell granules; there was also 5% eosinophils. Many L-cell granules were being produced between cell membranes of the same as well as neighboring L cells. It was thought that in this condition, as in other proliferative conditions of L cells, cell membranes are extremely adhesive and that such adhesion areas of L cells form L-cell granules. This occurs in a similar fashion as the adhesive areas of epithelial cells form desmosomes.
D000911:Antibodies, Monoclonal; D004803:Eosinophilic Granuloma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D005455:Fluorescent Antibody Technique; D005629:Frozen Sections; D005881:Gingiva / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D010159:Palate / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D014222:Triamcinolone Acetonide