Sequence analysis of the human major histocompatibility gene SX alpha.
The DP subregion of the human major histocompatibility complex contains two closely linked gene pairs, DP alpha, DP beta and SX alpha, SX beta. The exon-intron organization and the complete DNA sequence of the SX alpha gene are reported here. There are several mutations within the SX alpha gene which strongly suggest that it is a pseudogene. These include two frameshift mutations, one in the alpha 1 domain and the other in the cytoplasmic domain. A 5' splice site mutation at the end of the alpha 1 exon also exists. DNA sequence homology between DP alpha and SX alpha suggests that these genes arose through a gene duplication event.
D001483:Base Sequence; D003001:Cloning, Molecular; D008040:Genetic Linkage; D006682:HLA-DP Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D009154:Mutation; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D006682:HLA-DP Antigens; D000949:Histocompatibility Antigens Class II; D021382:Protein Sorting Signals