Influence of GYKI-13504, a new antioestrogen, on the responsiveness of isolated uterus removed from oestradiol pretreated rats to PGF2 alpha.
The responsiveness of the uteri of ovariectomized rats pretreated either with E2 or with a new antioestrogen, GYKI-13504 or with both agents simultaneously to PGF2 alpha was studied in vitro. The treatment with E2 caused a fortyfold reduction in the responsiveness of the uterus to PGF2 alpha. GYKI-13504 itself did not influence the sensitivity of this organ significantly, but inhibited the diminishing effect of E2.
D000818:Animals; D015237:Dinoprost; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D005260:Female; D010052:Ovariectomy; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects*
D004965:Estrogen Antagonists; D011460:Prostaglandins F; D013629:Tamoxifen; D004958:Estradiol; D015237:Dinoprost; C047993:panomifene