Effects in vivo of food deprivation and 3-mercaptopicolinate in the glycogen-storage-disease (gsd/gsd) rat.
Intraperitoneal injection of 3-mercaptopicolinate into 24 h-food-deprived 27-week-old female control (GSD/GSD) rats lowered the concentration of circulating glucose by 66%, but glycerol and lactate concentrations were increased up to 3- and 4-fold respectively. In phosphorylase b kinase-deficient (gsd/gsd) rats the corresponding changes for blood glucose, lactate and glycerol were half those observed in the controls. Although the concentration of liver glycogen (approx. 12%, w/w) in the gsd/gsd rats was not altered during food deprivation, total hepatic glycogen was decreased by 17%. It is suggested that the gradual breakdown of the extensive hepatic glycogen stores during starvation assists in the maintenance of normoglycaemia in the gsd/gsd rat.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005508:Food Deprivation / Q000502:physiology*; D005990:Glycerol / Q000097:blood; D006008:Glycogen Storage Disease / Q000097:blood / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008099:Liver / Q000187:drug effects; D008112:Liver Glycogen / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D007773:Lactates; D008112:Liver Glycogen; D010848:Picolinic Acids; D019344:Lactic Acid; C008363:3-mercaptopicolinic acid; D005990:Glycerol