Interaction between des-Tyr1-gamma-endorphin and HLA class I molecules: serological detection of an HLA-A2 subtype.
Preincubation of lymphocytes with des-Tyr1-gamma-endorphin (DT gamma E) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DT gamma E-treated lymphocytes from some donors. Comparison with the HLA-A2 subtypes as defined by a combination of cytotoxic T lymphocyte typing and biochemistry showed a complete correlation with the previously described HLA-A2.3 subtype.
D003601:Cytotoxicity Tests, Immunologic; D004723:Endorphins; D006680:HLA Antigens / Q000145:classification*; D015789:HLA-A2 Antigen; D006801:Humans; D007518:Isoantibodies; D010446:Peptide Fragments
D004723:Endorphins; D006680:HLA Antigens; D015789:HLA-A2 Antigen; D007518:Isoantibodies; D010446:Peptide Fragments; C018903:gamma-endorphin, des-Tyr(1)-