Increased interleukin II production during kidney allograft rejection.
We have studied the lectin-induced production of Interleukin II (IL-2) by peripheral blood leucocytes (PBL) obtained from recipients of kidney grafts. Pre-graft values (haemodialysed patients) are similar to those of healthy individuals. After grafting and during the first year the IL-2 levels produced by PBL from recipients with well functioning grafts are very low (p less than 0.001). Years after grafting the IL-2 yields tend towards restoration. At the onset of an acute rejection the IL-2 production rises significantly. These data show that an increase in IL-2 production may play a role in the rejection process.
D006084:Graft Rejection; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D016030:Kidney Transplantation; D007962:Leukocytes / Q000276:immunology
D007376:Interleukin-2