title: Anaphylactic and allergic reactions during double-contrast studies: is glucagon or barium suspension the allergen?
abstract: The authors report three anaphylactic reactions and one allergic reaction during double-contrast studies using glucagon. Symptoms included hives, periorbital edema, and breathing difficulties. Studies performed were three double-contrast barium enemas and one double-contrast upper gastrointestinal series. Glucagon injection and/or an additive in barium suspension are suspected as the likely causes. The allergic potential of glucagon injection, which is not generally appreciated, is reviewed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D001466:Barium Sulfate / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004733:Enema; D005260:Female; D005934:Glucagon / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001466:Barium Sulfate; D005934:Glucagon