title: Pimozide treatment in disruptive severely retarded patients.
abstract: Eight severely retarded residents took part in a double blind, placebo controlled trial of pimozide. The drug did not alter behavioural adjustment as assessed by behaviour observations. However, ratings on a standardised checklist of aberrant behaviour showed significant drug-induced improvements on two dimensions (Irritability and Hyperactivity/non-compliance). Learning performance, as assessed by a discrimination learning task, was not affected by the drug.
mesh_terms: D000293:Adolescent; D002986:Clinical Trials as Topic; D004193:Discrimination Learning / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008607:Intellectual Disability; D008297:Male; D010868:Pimozide / Q000627:therapeutic use*; D012920:Social Behavior Disorders / Q000188:drug therapy*
chemical_list: D010868:Pimozide