title: An investigation of the pharmacokinetic profile of propofol ('Diprivan') after administration for induction and maintenance of anaesthesia by repeat bolus doses in patients having spinal anaesthetic block.
abstract: In 12 premedicated patients, spinal anaesthesia was established with 0.5% bupivacaine. General anaesthesia was then induced using 2.5 mg/kg propofol given over 20s, and maintained by the administration of repeated bolus doses of 1 mg/kg propofol given 3 min after induction and at intervals of 6 min thereafter. Anaesthesia was successfully induced and maintained by this technique and recovery from anaesthesia in most patients was rapid. Blood samples were collected 2 and 6 min after each dose and at recovery in order to determine the concentrations of propofol. Pharmacokinetic data were fully evaluated in 5 patients whose dosing and sampling regimen did not differ from the methods described above. Propofol blood concentrations declined rapidly between the 2 and 6 min samples, indicating rapid distribution of propofol from blood into tissues. In 3 of the 5 patients slight accumulation of propofol occurred although there was no consistent trend. There was a wide inter-individual variability in propofol concentrations on waking.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D000775:Anesthesia, Spinal; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000008:administration & dosage / Q000378:metabolism*; D015742:Propofol
chemical_list: D010636:Phenols; D015742:Propofol