title: Activation of protein kinase C modulates the expression of the T3/T cell antigen receptor complex on human T lymphocytes.
abstract: Activators of protein kinase C induced a rapid decrease (within 15 min) in the surface expression of the T3 antigen and T-lymphocyte antigen receptor (Ti) on HPB-ALL cells, and a concomitant phosphorylation of the T3 gamma and delta polypeptides; the gamma chain was more extensively phosphorylated than the delta chain. No phosphorylation of the T3 epsilon chain and the Ti alpha and beta polypeptides was detected. Evidence was obtained that the T3 gamma chain is phosphorylated only on serine residues.
mesh_terms: D004789:Enzyme Activation; D006801:Humans; D007700:Kinetics; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics*; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology*
chemical_list: D010761:Phosphorus Radioisotopes; D011948:Receptors, Antigen, T-Cell; D011493:Protein Kinase C