DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease.
We have studied the frequency of HLA-DR, -MT, and -MB antigens in adult patients with coeliac disease and in a group of healthy controls, evaluating the strength of the observed associations by measuring the aetiologic fractions. Among the antigens significantly associated with coeliac disease, MB2 (DQw2) showed an aetiologic fraction higher than those of DR3 and DR7. Our results suggest that MB2, as associated more frequently than other specificities with a hypothetical disease predisposing gene, may play a role in the pathogenesis of coeliac disease. The significant association of DR3 and DR7 with coeliac disease may be ascribed to linkage disequilibrium of these antigens with MB2.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000276:immunology*; D004198:Disease Susceptibility; D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000032:analysis*; D008875:Middle Aged
D006684:HLA-DR Antigens; D015803:HLA-DR3 Antigen; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II; D007126:Immunoglobulin Allotypes