Analgesic, anti-inflammatory and oxy-radical scavenger activity of imidazole and imidazole derivatives.
The author describes the recent work of his laboratory on imidazole. It increased the analgesic effects of morphine, and rivalled acetylsalicylic acid as an analgesic antipyretic agent. At 160 mg/kg, imidazole protected rats against indomethacin-induced gastric ulcers. It was equal to acetylsalicylic acid in reducing carrageenan inflammation, and was superior to it as anti-arthritic drug. Imidazole 2-hydroxybenzoate caused 36% inhibition of synovial fluid depolymerization.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy; D013582:Synovial Fluid / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D001241:Aspirin