Liver transplantation with cyclosporine and low-dose corticosteroids.
Twenty consecutive patients receiving 21 hepatic transplants were treated with cyclosporine and low-dose corticosteroids. Survival was 80 per cent at 30 days, 75 per cent at 6 months, and 65% in the 6-17 months follow-up period. Compared with earlier series, this improved survival using cyclosporine results from fewer infectious and sound healing complications. Reliance on hepatic biopsy to confirm the diagnosis of rejection may also reduce the corticosteroid exposure and help diminish the complications of excessive immunosuppression.
D001706:Biopsy; D003524:Cyclosporins / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006084:Graft Rejection; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000601:surgery; D016031:Liver Transplantation; D008775:Methylprednisolone / Q000008:administration & dosage*; D011241:Prednisone / Q000008:administration & dosage*; D014184:Transplantation, Homologous / Q000401:mortality
D003524:Cyclosporins; D011241:Prednisone; D008775:Methylprednisolone