A selective defect in secretion of alpha 1-proteinase inhibitor PiZZ demonstrated in surrogate and primary extrahepatic cell culture.
D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D009865:Oocytes / Q000378:metabolism; D010641:Phenotype; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014981:Xenopus; D000515:alpha 1-Antitrypsin / Q000235:genetics / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency
D012333:RNA, Messenger; D000515:alpha 1-Antitrypsin