title: 5q - marker chromosome in acute leukemia with lymphoid morphology and myeloid differentiation antigens.
abstract: We present three patients, two children and one adult, with an unusual type of acute leukemia. Whereas the blast cells showed lymphoid morphology with correlating cytochemical staining, immunological phenotyping showed a pure myeloid in one and a biphenotypic (mixed lymphoid/myeloid) membrane marker profile in two of the patients. Cytogenetic studies revealed a 5q - chromosome as a common marker with additional individual changes. Two of the patients who were treated according to ALL-therapy protocols died without remission 5 and 4 weeks after diagnosis, respectively. Despite relapsing several times, the third patient survived for over 8 years. These three patients seem to represent one new subgroup of leukemias which can only be distinguished from typical ALL by determination of both cell surface markers and cytogenetic analysis.
mesh_terms: D000368:Aged; D002648:Child; D002675:Child, Preschool; D002905:Chromosomes, Human, 4-5; D005260:Female; D005819:Genetic Markers; D006023:Glycoproteins / Q000032:analysis*; D006131:Growth Inhibitors; D006801:Humans; D015850:Interleukin-6; D007621:Karyotyping; D053605:Leukemia Inhibitory Factor; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008222:Lymphokines; D008297:Male; D010641:Phenotype
chemical_list: D005819:Genetic Markers; D006023:Glycoproteins; D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines