Intraocular pressure changes with propofol ('Diprivan'): comparison with thiopentone.
The effects of propofol, a new non-barbiturate intravenous anaesthetic agent, on intraocular pressure (IOP) were assessed and compared with those of thiopentone. IOP was measured using an applanation tonometer for 5 min following administration of induction doses of propofol or thiopentone and inhalation of 66% nitrous oxide in oxygen. Both agents produced a significant fall in IOP for the period of study, by a maximum of 53% with propofol and 40% with thiopentone. Apnoea occurred with similar frequency in the two groups. Use of propofol was associated with a significant fall in arterial pressure and pain on injection in 5 out of 20 patients.
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010636:Phenols / Q000009:adverse effects / Q000494:pharmacology*; D015742:Propofol; D013874:Thiopental / Q000009:adverse effects / Q000494:pharmacology*
D010636:Phenols; D013874:Thiopental; D015742:Propofol