[Absence of the reaction of insulin receptors to receptorotropic activity in the rat liver with innervation lesions].
Section of the hepatic nervous plexus did not affect insulin receptor parameters in hepatic or adipose tissue plasma membranes. In control rats, the increase of the receptor insulin binding in fasting and its fall under experimental hyperinsulinemia were found both in hepatic and adipose tissue membranes, while in the rats with lesioned hepatic innervation these changes only occurred in adipose tissue membranes. No insulin receptor response to fasting or hyperinsulinemia in the rat liver with lesioned innervation occurred. The vegetative nervous system seems to affect the insulin receptors in the insulin target tissues. The nervous regulation of the receptors in addition to the humoral one, increases the effectiveness of the insulin metabolic control in its target cells.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003714:Denervation; D005215:Fasting; D006946:Hyperinsulinism / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000502:physiology*
D007328:Insulin; D011972:Receptor, Insulin
Otsutstvie reaktsii insulinovykh retseptorov na retseptorotropnye vozdeĭstviia v pecheni krys s narushennoĭ innervatsieĭ.