title: Malignant transformation rate in oral submucous fibrosis over a 17-year period.
abstract: Sixty-six patients with oral submucous fibrosis were followed-up for a period of 17 yr (median observation 10 yr) in Ernakulam District, Kerala, India. Oral cancer developed in five (7.6%) patients. The malignant transformation rate in the same sample was 4.5% over a 15-yr observation period (median 8 yr). These findings impart a high degree of malignant potential to this condition.
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007194:India; D008875:Middle Aged; D009059:Mouth Diseases / Q000473:pathology*; D009062:Mouth Neoplasms / Q000453:epidemiology / Q000473:pathology*; D009914:Oral Submucous Fibrosis / Q000453:epidemiology / Q000473:pathology*