Transient neurologic disturbances induced by high-dose methotrexate treatment.
Temporary neurologic abnormalities were detected in 9 of 60 patients undergoing treatment with high-dose methotrexate and citrovorum factor rescue (MTX-CF) for osteosarcoma. The incidence of abnormalities and abnormalities themselves were more severe than previously reported. This was attributed to an increased dose and more frequent administration of MTX-CF. In view of the transient nature of the abnormalities, a biochemical cause is implicated, and the mechanisms by which it may occur are discussed.
D001859:Bone Neoplasms / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009422:Nervous System Diseases / Q000139:chemically induced*; D012516:Osteosarcoma / Q000188:drug therapy*
D002955:Leucovorin; D008727:Methotrexate