title: [Clinico-functional evaluation of the effectiveness of trental in the treatment of duodenal ulcer].
abstract: A study was made of microcirculation in patients with peptic ulcer of the duodenum during exacerbation and after combined antiulcerous therapy including trental that improves microcirculation and rheology of the blood. The data obtained point to the presence in the majority of patients of pronounced microcirculatory disorders during exacerbation. The degree of the disorders depended on the disease standing, acuity of the painful syndrome and the size of the ulcer. The use of trental as a constituent part of therapy led to significant correction of the altered parameters of microcirculation and reduction of the time of ulcer cicatrization. Application of trental entailed a reduction in secretory function of the gastric glands according to the data of fractional exploration. It is recommended that trental may be included into combined therapy of peptic ulcer of the duodenum.
mesh_terms: D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003228:Conjunctiva / Q000098:blood supply; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects; D013805:Theobromine / Q000031:analogs & derivatives*
chemical_list: D000897:Anti-Ulcer Agents; D013805:Theobromine; D010431:Pentoxifylline
vernacular_title: Kliniko-funktsional'naia otsenka éffektivnosti trentala v terapii iazvennoĭ bolezni dvenadtsatiperstnoĭ kishki.