title: Mutagenicity and toxicity of chloroethylene oxide and chloroacetaldehyde.
abstract: Exposure of several trp-auxotrophic Escherichia coli strains, carrying base-pair substitutions, to chloroethylene oxide or chloroacetaldehyde (two metabolites of vinyl chloride) increased the mutation frequency to tryptophan prototrophy. Strong cytotoxic and mutagenic effects were observed with 2.5 mM chloroethylene oxide, while a higher concentration of chloroacetaldehyde (100 mM) exhibited a mutagenic effect which was 400 times lower.
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005027:Ethylene Oxide / Q000031:analogs & derivatives / Q000633:toxicity*; D009153:Mutagens; D014364:Tryptophan / Q000235:genetics
chemical_list: D009153:Mutagens; C015061:chloroethylene oxide; D014364:Tryptophan; C004656:chloroacetaldehyde; D000079:Acetaldehyde; D005027:Ethylene Oxide