Cerebral blood flow with the continuous infusion of oxygen-15-labeled water.
This work describes the determination of CBF in eight normal human subjects with positron emission tomographic (PET) imaging using the continuous intravenous infusion of H2(15)O. A whole-brain CBF model is described that permits the comparison of the CBF values determined using PET with those obtained using other methods. This model includes a correction for whole-brain recovery coefficient, a correction for the underestimation of flow due to the nonlinearity of the CBF model when considering tissue that includes both gray and white matter, the use of in vitro-determined brain-blood partition coefficients for gray and white matter, and a variation of the equilibrium model that permits the arterial concentration to vary. CBF values using this method compare well with values determined previously. Regional determinations using a brain overlay atlas are presented. Radiation dosimetry for the continuous infusion of H2(15)O is also included.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002560:Cerebrovascular Circulation; D006801:Humans; D007263:Infusions, Parenteral; D010104:Oxygen Radioisotopes; D014055:Tomography, Emission-Computed; D014867:Water
D010104:Oxygen Radioisotopes; D014867:Water