title: Late effects of treatment of cancer in children.
abstract: Over the past two decades, owing to advances in surgical techniques, chemotherapy, and radiation therapy, there has been dramatic improvement in the survival of children with malignancies. Children cured of cancer will soon form a significant fraction of our adult population. As we follow such survivors, we have become more aware of long-term side effects of treatment. Therapy should not be withheld. Instead, careful follow-up of oncology patients is needed to document the adverse late effects, to identify the etiologic agents, and to alter treatment to give the least toxic therapy without sacrificing the quality or duration of survival.
mesh_terms: D000477:Alkylating Agents / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001847:Bone Diseases / Q000209:etiology; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002648:Child; D004700:Endocrine System Diseases / Q000209:etiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D009279:Naphthacenes / Q000009:adverse effects; D009369:Neoplasms / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D009422:Nervous System Diseases / Q000209:etiology; D010049:Ovarian Diseases / Q000209:etiology; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012306:Risk; D013122:Spinal Diseases / Q000209:etiology; D013733:Testicular Diseases / Q000209:etiology; D013959:Thyroid Diseases / Q000209:etiology; D013997:Time Factors; D014570:Urologic Diseases / Q000209:etiology
chemical_list: D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D009279:Naphthacenes