Posttraumatic autoimmune reaction in peripheral nerve: effect of two successive injuries at the same site.
We studied local autoimmune reactions in rat sciatic nerve after two successive injuries at the same site. The behavioral consequences of these injuries were also examined. We found that repetitive injuries had a moderately adverse effect on function and were accompanied by local autoimmune reactions. A causal relation between the two phenomena was possible but not clearly established.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology*; D005455:Fluorescent Antibody Technique; D008297:Male; D009474:Neurons / Q000098:blood supply; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000276:immunology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology; D013223:Statistics as Topic; D013997:Time Factors