Dendritic cell phenotype in localized malignant histiocytosis of the small intestine.
We studied a unique case of a localized non-Hodgkin's lymphoma of the pleomorphic large-cell type arising in the small intestine to determine its phenotype. Immunohistochemical staining for S100 protein, lysozyme, alpha 1-antitrypsin, and Leu-M1 was performed. Many lymphoma cells were positive for S100 protein and were negative with the other antibodies. These findings indicate a probable dendritic cell origin for this lymphoma similar to that seen in histiocytosis X and some cases of malignant histiocytosis, but apparently quite distinct from the S100 protein-negative, lysozyme-positive, alpha 1-antitrypsin-positive cells seen within the mononuclear phagocytic system.
D000328:Adult; D003712:Dendrites / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007580:Jejunal Neoplasms / Q000032:analysis / Q000145:classification / Q000473:pathology*; D008206:Lymphatic Diseases / Q000032:analysis / Q000145:classification / Q000473:pathology*; D008297:Male; D010641:Phenotype; D009418:S100 Proteins / Q000032:analysis
D009418:S100 Proteins