Bovine superoxide dismutase in Fanconi anaemia. Therapeutic trial in two patients.
Bovine superoxide dismutase (SOD) (Peroxinorm, Grünenthal Stolberg) was injected intramuscularly or subcutaneously in a daily dose of 4 mg over a period of six weeks into two patients with Fanconi anaemia. The effects (measured by the decrease of chromosome aberrations in blood lymphocytes and the increase in blood cells in venous blood) were evident but temporary. The hypothetical mode of action of SOD and the failure of a prolonged therapeutic effect are discussed.
D000741:Anemia, Aplastic / Q000188:drug therapy*; D000818:Animals; D002417:Cattle; D002648:Child; D002869:Chromosome Aberrations / Q000187:drug effects; D002986:Clinical Trials as Topic; D005199:Fanconi Anemia / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D013997:Time Factors
D013482:Superoxide Dismutase