[Correlation between the number of serotonin type 2 receptors in the frontal cortex of the mouse brain and the expressivity of serotonin-dependent head twitches].
The number of serotonin type 2 receptors (S2) was measured in the frontal cortex of mice belonging to 7 inbred strains using specific 3H-spiperone binding. In the same mice, measurements were also taken of the number of 5-hydroxytryptophan-induced (200 mg/kg i.p.) of head twitches (HT). A significant positive interspecific correlation was demonstrated between the number of S2 and HT. The conclusion is drawn that in the frontal cortex 3H-spiperone is bound to functionally active S2 and that the intensity of HT is largely controlled by the genetically determined number of S2 in the brain.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D005625:Frontal Lobe / Q000032:analysis*; D006257:Head; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009068:Movement / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000032:analysis*
D011985:Receptors, Serotonin; D006916:5-Hydroxytryptophan
Korreliatsiia mezhdu kolichestvom serotoninovykh retseptorov vtorogo tipa vo frontal'noĭ kore mozga mysheĭ i vyrazhennost'iu serotoninzavisimogo vstriakhivaniia golovoĭ.