title: Genetic studies on the skin lupus band test in New Zealand mice.
abstract: We found that the lupus band test (LBT) is frequently positive in the tail skin in NZB and NZB X NZW (B/W) F1 hybrid mice. Genetic mode of development of this positivity was investigated in female NZB, NZW, B/W F1 hybrid and B/W F1 X NZW back-cross mice and the incidences were 60%, 0%, 100% and 42% by 12 months of age, respectively. It was found that B/W F1 hybrid mice showed not only a higher incidence but also an earlier onset of LBT positivity than did the parental NZB mice. These findings suggested that a single dominant locus in NZB strain determines the appearance of a positive LBT and that this trait is to a great degree intensified by the involvement of NZW gene(s) in B/W F1 hybrid mice. Linkage studies indicated that the NZB gene is to some extent linked to H-2 complex. In addition, there were significant associations between the LBT positivity and the appearances of anti-dsDNA antibodies and renal disease in B/W F1 X NZW back-cross mice. Thus, it is suggested that the NZB-LBT gene is the gene itself or closely linked, on chromosome 17, to that related in part to the occurrence of anti-DNA antibodies and renal disease. There was a lack of retroviral gp70 deposition at the dermo-epidermal junction in NZB and B/W F1 hybrid mice, in that the gp70 is the predominant antigen in the immune complexes deposited in the diseased renal glomeruli.
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D004247:DNA / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000235:genetics* / Q000276:immunology; D006183:H-2 Antigens / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D011507:Proteinuria / Q000235:genetics / Q000276:immunology; D012867:Skin / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D006183:H-2 Antigens; D007136:Immunoglobulins; D004247:DNA