Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury.
We measured levels of thromboxane B2 and 6-keto-PGF1 alpha in rabbit spinal cord and cat CSF after impact injury to spinal cord. Rabbit tissue thromboxane B2 levels increased more than 6-keto-PGF1 alpha. In cat, CSF thromboxane B2 was higher the first hour postinjury; CSF 6-keto-PGF1 alpha also increased, but less so. These results imply activation of arachidonic acid metabolism. The relatively greater increase of thromboxane B2 suggests that thromboxane-prostacyclin imbalance may contribute to post-traumatic ischemia.
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis / Q000134:cerebrospinal fluid; D000818:Animals; D002415:Cats; D011464:Epoprostenol / Q000032:analysis* / Q000134:cerebrospinal fluid; D008297:Male; D011817:Rabbits; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid / Q000378:metabolism*; D013928:Thromboxane A2 / Q000032:analysis* / Q000134:cerebrospinal fluid; D013929:Thromboxane B2 / Q000032:analysis / Q000134:cerebrospinal fluid; D013931:Thromboxanes / Q000032:analysis*
D013931:Thromboxanes; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol