[Protective activity of a cell-free Klebsiella vaccine in infection in mice caused by Streptococcus pneumoniae serotypes].
The capacity of dried Klebsiella cell-free vaccine, obtained from strain No. 204 by the disintegration of microbial mass with hydroxylamine, for protecting mice from pneumococcal infection caused by S. pneumoniae, serotypes 3, 4 and 9N, has been studied. Klebsiella vaccine has been found to possess immunostimulating potency with respect to the S. pneumoniae serotypes under study. On day 5 this potency is manifested to a greater extent than 24 hours after immunization. The combination of Klebsiella vaccine with Proteus vulgaris, Staphylococcus aureus and Escherichia coli K-100 antigens enhances the stimulation of nonspecific resistance.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology / Q000302:isolation & purification / Q000627:therapeutic use*; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology; D007114:Immunization; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D011008:Pneumococcal Infections / Q000276:immunology / Q000628:therapy*; D011514:Proteus vulgaris / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004338:Drug Combinations
Protektivnaia aktivnost' beskletochnioĭ klebsielleznoĭ vaktsiny v otnoshenii sepsisa u mysheĭ, vyzyvaemogo nekotorymi serotipami Streptococcus pneumoniae.