Effects of caffeine on ultraviolet-induced base-pair substitution and frameshift mutagenesis in Salmonella.
Using an excision-deficient, di-auxotrophic, strain of Salmonella typhimurium we have shown that caffeine significantly inhibits the formation of ultraviolet-induced base-pair substitution mutations, but has only a marginal effect on the formation of frameshift mutations in the same population of cells.
D002110:Caffeine / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D012486:Salmonella typhimurium / Q000187:drug effects*; D013698:Templates, Genetic; D014466:Ultraviolet Rays
D002110:Caffeine