Tubular proteinuria during treatment with cyclosporin A--a case report.
A patient with relapsing polychondritis developed a progressive destruction of tracheal cartilage despite treatment with immunosuppressive and cytotoxic agents. Cyclosporin A therapy was instituted and has been continued for more than two years, concomitant with a steady improvement and remission of the disease. During the treatment period an increased urinary excretion of beta 2-microglobulin was measured, indicating renal tubular damage. The tubular proteinuria preceded an elevation of serum creatinine and a drop in creatinine-clearance. Thus, beta 2-microglobulin might be a sensitive indicator of nephrotoxicity and of value for the evaluation of the long-term side effects of Cyclosporin A particularly in patients with extrarenal disease.
D003404:Creatinine / Q000378:metabolism; D003524:Cyclosporins / Q000009:adverse effects*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects*; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced*; D001613:beta 2-Microglobulin / Q000652:urine
D003524:Cyclosporins; D001613:beta 2-Microglobulin; D003404:Creatinine