Cyclosporine-associated renal arteriopathy resulting in loss of allograft function.
Cyclosporine-associated arteriopathy was the cause of graft loss in 40 percent of all allografts that failed in a series of 200 consecutive cadaveric renal transplants. Arteriopathy was diagnosed by biopsy and renal uptake of indium 111m labeled platelets in the face of acute renal deterioration. A moderate thrombocytopenia and microangiopathic picture of hemolytic uremia was also present on peripheral blood smear. Immunofluorescence and histologic characteristics of the allograft biopsy specimens failed to show evidence for acute rejection: immunoglobulin M, immunoglobulin A, immunoglobulin G, C1q, C3, and C4 were not present, and there was no evidence of an interstitial or vascular mononuclear cellular infiltrate. Two clinical presentations have been described. In Group I (seven patients), anuria occurred rapidly within the first 2 weeks after transplantation. In Group II (nine patients) renal function gradually diminished 1 to 5 months after starting cyclosporine therapy. Fifteen of the 16 recipients had progressive and irreversible loss of renal function which was pathologically associated with fibrin deposition, intimal proliferation, and thrombotic occlusion of the cortical interlobular and arcuate arteries, with subsequent focal glomerular ischemia and cortical infarction. One recipient with rapid loss of renal function received an intraarterial allograft infusion of streptokinase and subsequent systemic heparinization, which resulted in return of normal allograft function. The syndrome of cyclosporine-associated arteriopathy has been linked to a lack of or reduced amounts of prostacyclin-stimulating factor or prostacyclin.
D001157:Arterial Occlusive Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D001706:Biopsy; D001792:Blood Platelets; D002102:Cadaver; D003524:Cyclosporins / Q000009:adverse effects* / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007204:Indium; D007668:Kidney / Q000000981:diagnostic imaging / Q000473:pathology; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008875:Middle Aged; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors
D003524:Cyclosporins; D007166:Immunosuppressive Agents; D011868:Radioisotopes; D007204:Indium