Effects of inactivated streptococci (OK-432) on macrophage functions in mice.
The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated. In vivo treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of la antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology / Q000473:pathology; D001688:Biological Products / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D005260:Female; D000949:Histocompatibility Antigens Class II; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D010844:Picibanil / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*
D001688:Biological Products; D000949:Histocompatibility Antigens Class II; D010844:Picibanil