Disseminated histiocytosis X complicated by diffuse erythrophagocytosis: report of two cases.
Two children with the clinical and histopathological features of disseminated histiocytosis X became refractory to chemotherapy and a diffuse erythrophagocytic process developed. No cause of the erythrophagocytosis could be found. Pancytopenia and marked erythrophagocytosis persisted until death ensued. The relationship of this disorder to familial erythrophagocytosis is discussed.
D002675:Child, Preschool; D004912:Erythrocytes / Q000166:cytology / Q000502:physiology*; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D010587:Phagocytosis; D011241:Prednisone / Q000627:therapeutic use; D014747:Vinblastine / Q000627:therapeutic use
D014747:Vinblastine; D011241:Prednisone