Combined features of pemphigus and pemphigoid induced by penicillamine.
D-Penicillamine is able to induce a bullous eruption with the clinical, histological and immunological features of pemphigus. We present a case that had all the characteristics of pemphigus, but also in vivo bound IgG against the dermo-epidermal junction, i.e. the immunological features of bullous pemphigoid. Since no subepidermal blistering was observed, it is concluded that the penicillamine-induced auto-antibodies against the basement membrane zone were biologically inactive.
D000368:Aged; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010391:Pemphigoid, Bullous / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D010392:Pemphigus / Q000139:chemically induced* / Q000150:complications / Q000276:immunology; D010396:Penicillamine / Q000009:adverse effects*; D012867:Skin / Q000276:immunology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*
D007136:Immunoglobulins; D010396:Penicillamine