Flurbiprofen and immunosuppression of Trypanosoma brucei infection in the goat.
Goats infected with Trypanosoma brucei and treated with the non-steroidal anti-inflammatory agent flurbiprofen, showed a marked increase in parasitaemia, followed in one of the four goats by death. The in vitro response to mitogens of peripheral blood lymphocytes and separated T- and B-lymphocytes from healthy goats treated with flurbiprofen was normal when compared with non-treated animals. T. brucei-infected goats, not treated with flurbiprofen, showed a marked immunosuppression which was mainly localized in the B-enriched lymphocyte fraction. A combination of T. brucei infection and treatment with flurbiprofen led to even more suppression, because the T-lymphocyte function was also suppressed. It is concluded that flurbiprofen first causes a rise in the parasitaemia and that this high parasitaemia is responsible for the observed immunosuppression.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001769:Blood / Q000469:parasitology; D003864:Depression, Chemical; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology* / Q000627:therapeutic use; D006041:Goats; D007108:Immune Tolerance / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D011422:Propionates / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology; D014353:Trypanosomiasis, African / Q000188:drug therapy / Q000276:immunology / Q000662:veterinary*
D011422:Propionates; D005480:Flurbiprofen