Isoenzymes in plasma of acute leukaemia patients: prevention of anthracycline cardiomyopathy.
During the diagnosis and subsequent monitoring of patients with acute leukaemia, and of those with terminal blastic crisis in chronic myelogenous leukaemia, the activity of total LDH, ALAT, AP, ASAT as well as the isoenzymes LDH-H, LDH-M were measured in the plasma. Enzyme and isoenzyme activity of LDH, which differed in quantity at the various times of measurement, reflected the varying proliferation rate, depending upon the individual and upon the time of measurement and, consequently, the tumour cell mass.
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D009202:Cardiomyopathies / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007938:Leukemia / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D009279:Naphthacenes / Q000633:toxicity
D000903:Antibiotics, Antineoplastic; D007527:Isoenzymes; D009279:Naphthacenes; D007770:L-Lactate Dehydrogenase