Role of T cells in preventing transmission of rodent malaria.
Transmission blocking immunity induced by microgamete vaccination is fully effective for at least 12 months. Passive transfer of immune T cells reduced transmission of a subsequent infection by 95%, the effect being partly due to a significant reduction in numbers of circulating gametocytes during the infection. This immunity was apparently independent of specific antibody, though these were produced within a few days after challenge infection and was mediated by a T cell of the GK1.5+, Ly 2.2 phenotype. Immune serum and immune T cells, administered together, showed a strong additive effect and blocked transmission completely.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000953:Antigens, Protozoan / Q000276:immunology; D007116:Immunization, Passive; D008288:Malaria / Q000276:immunology* / Q000635:transmission; D051379:Mice; D008807:Mice, Inbred BALB C; D010961:Plasmodium / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
D000953:Antigens, Protozoan