Effects of long-term catheter implantation on the contractile and histological properties of the canine bladder.
In beagles, a bladder catheter was surgically implanted and subvesical obstruction was artificially introduced. After 3 months a striking reduction in detrusor contractility measured in vitro was observed, which was associated with a presumptive reduction in the concentration of acetylcholinesterase in the muscle cells and a probable reduction in the mean cell size. In this model the contribution of the catheter to the changes is greater than that of the subvesical obstruction.
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001706:Biopsy; D004285:Dogs; D005549:Foreign-Body Reaction / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors; D001743:Urinary Bladder / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D014546:Urinary Catheterization / Q000009:adverse effects*; D014563:Urodynamics
D000110:Acetylcholinesterase