title: [Genetic analysis of the indices of gastric acid secretory and proteolytic functions in duodenal ulcer patients].
abstract: The phenotypic correlations between pepsinogen, proteases and the debit of acid secretion in patients with the peptic ulcer of duodenum and their parents were studied. It was found that the genetic factors have great influence on the level of pepsinogen and proteases in the basal conditions and under stimulation. In comparison with the general population, we obtained highly reliable increase of the level of pepsinogen and proteases in the groups of patients and their parents.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood; D010447:Peptide Hydrolases / Q000378:metabolism*; D010641:Phenotype; D013270:Stomach / Q000201:enzymology*
chemical_list: D010435:Pepsinogens; D010447:Peptide Hydrolases
vernacular_title: Geneticheskiĭ analiz pokazateleĭ kislotovydelitel'noĭ i proteoliticheskoĭ funktsiĭ zheludka u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki.