Proliferative lesions of the exocrine pancreas: relationship to corn oil gavage in the National Toxicology Program.
A microscopic review of pancreata from corn oil vehicle control and untreated control F344/N male rats in thirty-seven 2-year carcinogenesis studies was conducted to determine the extent and strength of the association of proliferative exocrine pancreatic lesions with corn oil gavage. The incidence of focal basophilic cellular change was similar in both untreated and vehicle control groups and was unrelated to corn oil gavage. The overall incidences of focal acinar hyperplasia and acinar adenoma were about five times greater in male rats that received the corn oil than in untreated rats (12.6 and 4.9% vs. 2.6 and 0.9%). This association was not consistent for each study group of vehicle controls. Over one-third (7/20) of the vehicle control groups had incidences of hyperplasia and adenoma no greater than the average rate for untreated male rats. There was no relationship between incidences of proliferative acinar lesions and the animal laboratory, the animal source, and the brand, lot, or peroxide level of the corn oil. The incidences of focal acinar hyperplasia and acinar adenoma were related to maximum mean body weights attained by the groups during the course of the study.
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D003314:Corn Oil; D006965:Hyperplasia / Q000139:chemically induced; D007441:Intubation, Gastrointestinal; D008297:Male; D009821:Oils / Q000008:administration & dosage / Q000633:toxicity*; D010182:Pancreatic Diseases / Q000139:chemically induced / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D014116:Toxicology / Q000379:methods; D014481:United States
D009821:Oils; D014677:Pharmaceutical Vehicles; D003314:Corn Oil