Immune hemolytic anemia following administration of antithymocyte globulin.
Antithymocyte globulin is commonly used as a therapy for rejection of transplanted organs. Its use can be associated with many side effects. We report a significant hemolytic anemia following therapy with horse-derived antithymocyte globulin. Several commercial Coombs' sera failed to yield a positive Coombs' test with the patient's erythrocytes; however, we were able to detect horse immunoglobulin on the patient's cells as well as on control red cells incubated with this particular preparation of antithymocyte globulin.
D000293:Adolescent; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects*; D003298:Coombs Test; D005260:Female; D016027:Heart Transplantation; D006736:Horses / Q000276:immunology; D006801:Humans; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum