Antifungal drugs affecting the chemotaxis of polymorphonuclear neutrophils.
Investigations on the chemotaxis of polymorphonuclear neutrophils (PMNs) towards a cytoplasmic extract of Trichophyton rubrum in the presence and absence of antifungal drugs are described. It is shown that with griseofulvin, clotrimazole, econazole, ketoconazole, miconazole and natamycin at 1 mg l(-1), the number of PMNs migrating was significantly reduced. After 3 h of exposure to 10 mg l(-1), not one of the drugs tested had any discernable effect on the viability of the PMNs, or the complement. The anti-inflammatory activity of the drugs is discussed and whilst the chemosuppression of PMN chemotaxis may be an undesirable feature in a drug used to treat systemic mycoses, it is unlikely to have any adverse effect in the therapy of the dermatophytoses.
D000935:Antifungal Agents / Q000494:pharmacology*; D002457:Cell Extracts; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003022:Clotrimazole / Q000494:pharmacology; D003165:Complement System Proteins / Q000276:immunology; D004464:Econazole / Q000494:pharmacology; D006118:Griseofulvin / Q000494:pharmacology; D006801:Humans; D007654:Ketoconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D010866:Natamycin / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D014249:Trichophyton
D000935:Antifungal Agents; D002457:Cell Extracts; D006118:Griseofulvin; D004464:Econazole; D008825:Miconazole; D010866:Natamycin; D003165:Complement System Proteins; D003022:Clotrimazole; D007654:Ketoconazole