The use of captopril to control hypertension in post-transplant renal artery stenosis.
Captopril is a new orally active angiotensin converting enzyme inhibitor that is useful for the treatment of hypertension. Prior reports have cautioned against its use for the control of blood pressure in patients with transplant renal artery stenosis since it caused a reversible renal failure. We describe a four year old child with radiographically proven transplant renal artery stenosis and severe hypertension that was safely managed with long-term administration of captopril. This case highlights the continued therapeutic role of this drug in the treatment of post-transplant hypertension, provided one carefully monitors the renal function in such patients.
D002216:Captopril / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy* / Q000209:etiology; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications; D011392:Proline / Q000031:analogs & derivatives*; D011859:Radiography; D012078:Renal Artery Obstruction / Q000150:complications / Q000000981:diagnostic imaging / Q000209:etiology*
D011392:Proline; D002216:Captopril