Intestinal pathology in the dog induced by sublethal doses of amiodarone.
Amiodarone (A), an unique antiarrhythmic agent and amphiphilic drug, induces at sublethal doses dyslipidic storage in animals. The present work demonstrates a distinct intestinal pathology or "Malabsorption Syndrome" in the dog induced by A. Signs of intestinal pathology were observed in all animals receiving 100 mg/kg, but not in those receiving less than 50 mg/kg, after one month. The malabsorption syndrome was demonstrated by a dynamic study of lipid absorption and pathological lesions (partial villous atrophy and the accumulation of macrophages with dyslipidic inclusions.
D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001572:Benzofurans / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced; D004285:Dogs; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D050356:Lipid Metabolism; D008264:Macrophages / Q000473:pathology; D008286:Malabsorption Syndromes / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008297:Male; D014280:Triglycerides / Q000097:blood
D001572:Benzofurans; D014280:Triglycerides; D000638:Amiodarone