Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice.
A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.
D000818:Animals; D004247:DNA / Q000235:genetics; D005260:Female; D005796:Genes; D005818:Genetic Engineering; D006084:Graft Rejection; D006183:H-2 Antigens / Q000235:genetics; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D008845:Microinjections; D009693:Nucleic Acid Hybridization; D016038:Skin Transplantation; D013552:Swine
D006183:H-2 Antigens; D004247:DNA