Circulatory responses to thiopentone and tracheal intubation in patients with coronary artery disease. Effects of pretreatment with labetalol.
The haemodynamic responses to induction and tracheal intubation have been studied in patients with coronary artery disease randomly assigned to a labetalol pretreatment group (n = 14) or to a placebo group (n = 16). Twelve hour before operation, treated patients received a bolus dose of labetalol 0.5 mg kg-1 followed by a constant infusion of 0.1 mg kg-1 h-1 i.v. Anaesthesia was induced with thiopentone and phenoperidine, and intubation performed following the administration of suxamethonium. At intubation, the changes in heart rate (P less than 0.01), mean arterial pressure (P less than 0.05) and rate-pressure product (P less than 0.01) were significantly smaller in the labetalol group compared with the placebo group. Labetalol pretreatment appears satisfactory and may be useful in patients with coronary artery disease who have a normal left ventricular ejection fraction.
D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000503:physiopathology*; D004311:Double-Blind Method; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007442:Intubation, Intratracheal; D007741:Labetalol / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D013874:Thiopental; D014655:Vascular Resistance / Q000187:drug effects
D004983:Ethanolamines; D013874:Thiopental; D007741:Labetalol