Clinical symptoms and HLA antigens in a family with Reiter's disease.
A clinical and immunogenetic study was performed on a three-generation family with Reiter's disease (RD). Twelve of 56 members of the family (33 clinically examined) including one in-law, had symptoms of arthritis, urethritis, conjunctivitis, uveitis, and/or mucocutaneous manifestations, but only one had the complete triad of Reiter's syndrome (RS). Radiographic sacro-iliitis was found in 7 individuals, and monoarticular onset was reported in 5 out of 7 with peripheral arthritis. HLA B27 was found in 26 of the 37 family members who were tissue typed (including one in-law). All individuals with RD were B27-positive. Seven different B27 phenotypes were identified. This finding suggests that RD is associated with the B27 antigen itself, and not to a gene closely linked to B27. From a pedigree analysis of this family an autosomal dominant inheritance with incomplete penetrance or multifactorial inheritance seemed the most probable alternatives. The family history is a useful adjunct in the diagnosis of RD.
D000293:Adolescent; D000328:Adult; D000368:Aged; D016918:Arthritis, Reactive / Q000000981:diagnostic imaging / Q000235:genetics* / Q000276:immunology; D001175:Arthrography; D005260:Female; D005799:Genes, Dominant; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012871:Skin Diseases / Q000235:genetics; D013131:Spine / Q000000981:diagnostic imaging; D014526:Urethritis / Q000235:genetics; D014605:Uveitis / Q000235:genetics
D006680:HLA Antigens; D015796:HLA-B27 Antigen