[Familial cytogenetic studies in Balkan endemic nephropathy. II].
Twenty clinically healthy relatives were studied of patients with Balkan endemic nephropathy via high resolutive chromosome analysis. Dynamic deviations in G-band structure of third chromosome was established in 10 of the subjects studied, namely--shortening of the band 3q25 and a faster fusion of subbands 3q26.1 and 3q26.3, not corresponding to the stage of chromosomal contraction. A complete coincidence was obtained between the carriership if marker chromosome A3 and the data from the biopsy studies, revealing initial morphological changes in the kidney, characteristic for Balkan endemic nephropathy.
D000293:Adolescent; D000328:Adult; D001449:Balkan Nephropathy / Q000235:genetics* / Q000473:pathology; D002648:Child; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D005260:Female; D006580:Genetic Carrier Screening; D005819:Genetic Markers; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000235:genetics*; D010375:Pedigree
D005819:Genetic Markers
Familni tsitogenetichni prouchvaniia pri balkanskata endemichna nefropatiia (II sŭobshtenie).