The insulin receptor of adult heart muscle cells.
Isolated cardiac myocytes possess specific receptors for insulin which consist of high- and low-affinity sites and are randomly distributed at the cell surface at 37 degrees C. Low-affinity sites can mediate a biological response comparable to that of high-affinity sites. Calcium appears to modulate the high-affinity site and thus may be involved in the regulation of cardiac sensitivity towards insulin. The data suggest involvement of the insulin receptor in insulin degradation, which includes internalization and lysosomal processing of insulin.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D007328:Insulin / Q000378:metabolism*; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism*
D007328:Insulin; D011972:Receptor, Insulin; D008274:Magnesium; D002118:Calcium