Beta-lactamases from Bacteroides fragilis active against oximino-cephalosporins.
Four clinical isolates of Bacteroides fragilis were resistant to penicillins and cephalosporins with exception to 7-alpha-methoxy cephalosporins such as latamoxef (moxalactam) and cefoxitin. In contrast the 6-alpha-methoxy penicillin temocillin was not active. The beta-lactam resistance correlates with the presence of two beta-lactamases with an isoelectric point (IEP) = 4.9 and 5.4, respectively. The necessity of antimicrobial susceptibility testing before the therapy of infections with anaerobic bacteria is discussed.
D001441:Bacteroides fragilis / Q000187:drug effects / Q000201:enzymology*; D002510:Cephalosporinase / Q000378:metabolism; D002511:Cephalosporins / Q000378:metabolism* / Q000494:pharmacology; D004355:Drug Stability; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000378:metabolism / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D010406:Penicillins; D002510:Cephalosporinase; D001618:beta-Lactamases