title: Severe combined respiratory and myocardial failure treated with high-frequency ventilation.
abstract: High levels of positive end-expiratory pressure (PEEP) impair cardiac output. The subsequent lowering of mixed venous oxygenation, when coupled with a significant intrapulmonary shunt, may dramatically depress PaO2. We present a patient whose severe myocardial and respiratory insufficiency was unmanageable on conventional ventilation with high levels of PEEP and maximal inotropic support. High-frequency ventilation superimposed on conventional ventilation lowered peak airway pressure and dramatically improved both cardiac and pulmonary function.
mesh_terms: D002302:Cardiac Output; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000628:therapy*; D013318:Stroke Volume; D014655:Vascular Resistance
chemical_list: D010100:Oxygen