title: [Synthesis and pharmacologic study of new esters of naproxen with derivatives of N-oxyethylpiperazine].
abstract: The preparation of naproxen esters with N,N'-dioxyethylpiperazine and derivatives of N-oxyethylpiperazine with various substituents on the nitrogen is described. Study of analgesic-antiinflammatory properties in comparison with a reference compounds has shown that in most of the new compounds analgesic activity (phenylquinone) is preserved whereas antiinflammatory activity (carrageenin) is generally reduced. The diester with N,N'-dioxyethylpiperazine (MG 28136) proved most interesting, showing clear pharmacological activity and very low toxicity.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D016227:Benzoquinones; D002351:Carrageenan / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D009288:Naproxen / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011809:Quinones / Q000037:antagonists & inhibitors; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D010879:Piperazines; D011809:Quinones; C029322:phenylbenzoquinone; D009288:Naproxen; D002351:Carrageenan
vernacular_title: Sintesi e studio farmacologico di nuovi esteri del naproxen con derivati dell'N-ossietilpiperazina.