Oral administration of liposome-entrapped cysteamine and the distribution pattern in blood, liver and spleen.
Oral administration of liposome-entrapped cysteamine induces an increase in the concentration of exogenous sulphur compounds in blood (plasma), liver and spleen. Among those sulphur compounds, an important amount of plasma thiols can be related to a protection of cysteamine in the digestive tract. This can account for the radioprotective effect of a liposomal-cysteamine suspension in rodents, and clearly demonstrates the interest of such a preparation in radioprotection.
D000284:Administration, Oral; D000818:Animals; D003543:Cysteamine / Q000008:administration & dosage / Q000378:metabolism*; D007408:Intestinal Absorption; D008081:Liposomes / Q000008:administration & dosage; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013053:Spectrophotometry; D013154:Spleen / Q000378:metabolism*; D013462:Sulfur Radioisotopes; D014018:Tissue Distribution
D008081:Liposomes; D013462:Sulfur Radioisotopes; D003543:Cysteamine