title: Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein.
abstract: A scarce, soluble, conserved protein was identified as the nonphosphorylated precursor of two related 42-kilodalton phosphoproteins that contain phosphotyrosine in mitogen-stimulated but not control fibroblasts.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D008715:Methionine / Q000378:metabolism; D051379:Mice; D008970:Molecular Weight; D010750:Phosphoproteins / Q000302:isolation & purification; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D013379:Substrate Specificity; D014316:Tritium
chemical_list: D010750:Phosphoproteins; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D014316:Tritium; D004815:Epidermal Growth Factor; D008715:Methionine; D011505:Protein-Tyrosine Kinases