A mutagen precursor in Chinese cabbage, indole-3-acetonitrile, which becomes mutagenic on nitrite treatment.
After treatment with nitrite, Chinese cabbage showed direct-acting mutagenicity on Salmonella typhimurium TA100 inducing 3100 revertants per g. One of the mutagen precursors that became mutagenic after nitrite treatment was isolated, and identified as indole-3-acetonitrile. After treatment with nitrite, 1 mg of indole-3-acetonitrile induced 17 400 revertants of TA100 and 21 000 revertants of TA98 without S9 mix.
D001711:Biotransformation; D007211:Indoles / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D009573:Nitrites; D010945:Plants, Edible / Q000032:analysis*; D012486:Salmonella typhimurium / Q000187:drug effects
D007211:Indoles; D009573:Nitrites; C016516:indole-3-acetonitrile