title: Erythromycin: a microbial and clinical perspective after 30 years of clinical use (2).
abstract: Erythromycin, first introduced for clinical use 30 years ago, was found to be effective for the treatment of gram-positive bacterial infections. Emergence of resistance and the advent of penicillinase-resistant penicillins limited the use of erythromycin for serious staphylococcal infections; however, erythromycin remains among the drugs of choice for the treatment of acne, infections of the skin and soft tissues, streptococcal pharyngitis, bronchitis, pneumonitis, diphtheria, carriers of pertussis, and, when administered with a sulfonamide, otitis media. Erythromycin is the drug of choice for the empiric treatment of outpatients with pneumonitis. Erythromycin is also the drug of choice for the treatment of Legionella pneumonia and is effective therapy for Chlamydia infections. Other uses of erythromycin include prophylaxis for elective colon operations and treatment of Campylobacter enteritis, genitourinary infections, and some sexually transmitted diseases.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D001991:Bronchitis / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002690:Chlamydia Infections / Q000188:drug therapy; D002779:Cholestasis / Q000139:chemically induced; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D004917:Erythromycin / Q000009:adverse effects / Q000627:therapeutic use*; D006192:Haemophilus Infections / Q000188:drug therapy; D006801:Humans; D007875:Legionella / Q000187:drug effects; D009175:Mycoplasma Infections / Q000188:drug therapy; D010033:Otitis Media / Q000188:drug therapy; D010612:Pharyngitis / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy
chemical_list: D004917:Erythromycin