title: Effect of 1,3-butanediol and short chain acids in sow gestation diets on maternal plasma metabolites and fetal energy storage.
abstract: Gestating sows were fed diets in which 15% of the metabolizable energy was in the form of glucose monohydrate (control), 1,3-butanediol (BD) or an equimolar mixture of acetate and lactate (AL) in order to study the effects of ketogenic, glucogenic and lipogenic substrates on fetal energy storage. Diets were initiated on d 90 of gestation. Blood plasma was obtained from sows 2 and 8 h after feeding on d 102 of gestation. Sows receiving BD had a higher (P less than .001) concentration of beta-hydroxybutyrate (.54 vs .12, .14 mM) and a lower (P less than .05) concentration of glucose (72 vs 82, 86 mg/dl) after 8 h than sows in control or AL groups, respectively. Sows in the AL group had a higher (P less than .10) acetate concentration at 2 h, but no difference was observed by 8 h. Lactate concentration was lower (P less than .10) in AL sows when compared with those in the control group (69 vs 101 mg/dl). Two pigs/litter were killed at birth and two/litter were fasted for 36 h with blood samples obtained at 12-h intervals. Newborn pigs from AL and BS sows had more total liver glycogen than pigs derived from control sows (4.18, 4.07 vs 3.09 g, respectively); however, this difference was significant only for pigs from AL sows (P less than .10). Pigs in BD and AL groups had a higher (17 to 25%), though not significantly different, glucose concentration than controls after 24 and 36 h of fasting.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D020155:3-Hydroxybutyric Acid; D000085:Acetates / Q000097:blood / Q000494:pharmacology*; D019342:Acetic Acid; D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D002072:Butylene Glycols / Q000494:pharmacology*; D004734:Energy Metabolism; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000494:pharmacology*; D006885:Hydroxybutyrates / Q000097:blood; D007328:Insulin / Q000097:blood; D007773:Lactates / Q000097:blood / Q000494:pharmacology*; D019344:Lactic Acid; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D013552:Swine / Q000378:metabolism*
chemical_list: D000085:Acetates; D001786:Blood Glucose; D002072:Butylene Glycols; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D007773:Lactates; D008112:Liver Glycogen; D019344:Lactic Acid; C028491:1,3-butylene glycol; D005934:Glucagon; D005947:Glucose; D019342:Acetic Acid; D020155:3-Hydroxybutyric Acid