Pertussis toxin potentiates anesthesia-induced renin secretion.
The plasma renin concentration was measured after anesthesia in control and in pertussis toxin-treated rats. The anesthetics increased renin secretion and this effect was markedly magnified in rats treated with pertussis toxin. Propranolol partially blocked the increase in plasma renin concentration produced by anesthetics. It is concluded that the adrenergic system is involved in this effect and that pertussis toxin magnifies it by potentiating the beta-adrenergic action.
D000758:Anesthesia; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D037342:Pertussis Toxin; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D010566:Virulence Factors, Bordetella; D015016:Yohimbine / Q000494:pharmacology
D001427:Bacterial Toxins; D010566:Virulence Factors, Bordetella; D015016:Yohimbine; D011433:Propranolol; D037342:Pertussis Toxin; D012083:Renin