[Concentrations of antibiotics (josamycin, trioleandomycin and amoxicillin) in the secretions of the ear, sinus and adenoids].
This was a comparative study of antibiotics in the pus of otitis and from the sinuses as well as in the adenoids. Three antibiotics were chosen: Trioleandomycin, Josamycin, Amoxicillin. The study protocol was strict. Results obtained were as follows: high concentrations of macrolids in discharge of otitis and the sinuses as well as in the adenoids. Concentrations were higher than serum concentrations. By contrast, in the case of amoxicillin tissue concentrations were lower than the serum concentration. This leads to the conclusion that there is good penetration of infectious ENT sites by macrolids.
D000234:Adenoids / Q000378:metabolism*; D000328:Adult; D000658:Amoxicillin / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002648:Child; D004432:Ear, Middle / Q000378:metabolism*; D006801:Humans; D006984:Hypertrophy; D007700:Kinetics; D007933:Leucomycins / Q000378:metabolism; D010031:Otitis / Q000188:drug therapy; D010256:Paranasal Sinuses / Q000378:metabolism*; D012852:Sinusitis / Q000188:drug therapy; D014018:Tissue Distribution; D014217:Troleandomycin / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007933:Leucomycins; D000658:Amoxicillin; D014217:Troleandomycin
Etude des concentrations d'antibiotiques (josamycine, trioléandomycine et amoxicilline) dans les sécrétions d'oreille, de sinus et dans les végétations adénoïdes.