Hemodynamic effects of molsidomine on weight sustaining isometric exercise in patients with ischemic heart disease.
Hemodynamic effects of 2 mg of sublingual molsidomine were evaluated in 11 patients with ischemic heart disease using a weight-sustaining isometric exercise (WSIE) that we developed. Left ventricular end diastolic pressure (LVEDP), mean pulmonary pressure, mean systemic arterial pressure (mAP), cardiac index and stroke work index increased significantly during WSIE before and after molsidomine. Although WSIE resulted in a similar rise of mAP before and after molsidomine, the increment value of LVEDP during WSIE was significantly lower after molsidomine. The recovery time to the resting state of all parameters was shorter and the left ventricular function curves showed a leftward deviation with molsidomine. In conclusion, the results suggest that molsidomine will produce a preload reduction and improve the left ventricular function during WSIE in patients with ischemic heart disease.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D008981:Molsidomine; D009119:Muscle Contraction; D010069:Oxadiazoles / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013558:Sydnones / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D010069:Oxadiazoles; D013558:Sydnones; D014665:Vasodilator Agents; D008981:Molsidomine