Unequal branch point filtering action in different types of dorsal root ganglion neurons of frogs.
The influence of the intraganglionic branch point on impulse conduction in single neurons of frog dorsal root ganglia (DRG) has been determined by measuring the least interval at which it will conduct two action potentials into the dorsal root. At 21-23 degrees C, branch points of myelinated fibers had long least conduction intervals and low safety factors for orthodromic impulse conduction compared to nodes of Ranvier in peripheral nerve. DRG neurons with broad somatic spikes with a shoulder on the falling phase and slowly conducting myelinated or non-myelinated axons had the longest least conduction intervals (lowest safety factors). DRG neurons with brief somatic spikes with little or no shoulder on the falling phase had short least conduction intervals (higher safety factor) regardless of their conduction velocity. The results indicate that certain DRG neurons have found a way to minimize branch point filtering action.
D000818:Animals; D001369:Axons / Q000502:physiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D008959:Models, Neurological; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology; D011894:Rana pipiens; D011901:Ranvier's Nodes / Q000502:physiology