Endoscopic evaluation of slow-release potassium chloride preparations.
In a double-blind, randomized, placebo-controlled clinical trial, 30 healthy subjects took one of two potassium chloride preparations or placebo three times a day for 1 week with concomitant oral glycopyrrolate dosing. The upper digestive tract was endoscopically examined immediately before and after the treatment period. One subject in both of the KCl treatment groups and six subjects in the placebo group developed submucosal lesions. All lesions were minor and of limited clinical significance. There may be reason to believe that glycopyrrolate plays a role in the production of such lesions. If so, the concomitant use of glycopyrrolate in clinical trials of KCl preparations may cloud the results of such studies.
D000328:Adult; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000209:etiology; D004724:Endoscopy / Q000009:adverse effects*; D005753:Gastric Mucosa / Q000187:drug effects*; D006024:Glycopyrrolate; D006801:Humans; D011189:Potassium Chloride / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011897:Random Allocation; D013276:Stomach Ulcer / Q000209:etiology
D003692:Delayed-Action Preparations; D011189:Potassium Chloride; D006024:Glycopyrrolate