The role of periconceptional vitamin supplementation in the prevention of neural tube defects.
The British Isles multicentre study of periconceptional vitamin supplementation in women with a previous infant with an NTD has demonstrated an apparent beneficial effect in reducing risk of recurrence of an NTD. In Northern Ireland, a similar significant effect has been observed with a reduction of the recurrence risk from 5.2% in unsupplemented to 0.7% in fully supplemented women. The problems and implications of periconceptional vitamin supplementation in the prevention of NTDs are discussed.
D002986:Clinical Trials as Topic; D004032:Diet; D004739:England; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000517:prevention & control*; D009660:Northern Ireland; D011247:Pregnancy; D012306:Risk; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins