Red blood cell membrane lipid peroxidation and chronic haemolysis in haemodialysis patients.
Pre dialysis concentrations of malonyldialdehyde (MDA) in the red blood cell membranes and pre and post dialysis percent variation of plasma haemoglobin levels are studied in a group of uraemic patients on maintenance haemodialysis both before and after a therapeutic trial with vitamin E. The findings show a significant correlation between MDA levels and percent variation of plasma haemoglobin during dialysis, thus indicating that reducing the amount of lipid peroxidation can help to reduce intradialytic chronic haemolysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000097:blood / Q000188:drug therapy / Q000628:therapy; D014810:Vitamin E / Q000494:pharmacology
D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D008315:Malondialdehyde