title: A comparative study of two dosage levels of ibuprofen syrup in children with pyrexia.
abstract: In a study of the antipyretic effect of two dosage levels of ibuprofen syrup in children with fever due to a variety of causes, forty-four out of the fifty children admitted completed the 24-hour trial period, twenty-three receiving 20 mg ibuprofen/kg body-weight, twenty-one receiving 30 mg/kg ibuprofen. Both dosage levels gave highly significant (p less than 0.001) reductions in rectal temperatures, with a statistically significant reduction, at the 5% level, in favour of the higher dose at 12 and 20 hours. No side-effects were reported at either dosage level, and the taste was acceptable to all the children. It is concluded that ibuprofen was a useful and effective antipyretic drug in the population studied, and that the higher dosage is preferable to the lower, being more effective, equally palatable, and giving rise to no side-effects in this study.
mesh_terms: D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D008297:Male
chemical_list: D007052:Ibuprofen