Influence of a vitamin E-deficient diet on prostacyclin production by mesometrial triangles and aortic rings from nondiabetic and diabetic pregnant rats.
We investigated the effect of a vitamin E-deficient diet on the synthesis of prostacyclin in nondiabetic and diabetic pregnant rats. In both groups the diet reduced fetal growth and prostacyclin production by mesometrial triangles; it also increased serum lipid peroxides, which are known to inhibit prostacyclin synthesis. Independently of the diet, mesometrial triangles of diabetic rats produced more prostacyclin than those of control rats, whereas an opposite tendency was found in the aortic rings. Our model seems useful for fundamental and pharmacologic studies of the vascular pathology of pregnancy.
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004032:Diet; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D008054:Lipid Peroxides / Q000097:blood; D008098:Litter Size; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000378:metabolism*
D001786:Blood Glucose; D008054:Lipid Peroxides; D014810:Vitamin E; D011374:Progesterone; D011464:Epoprostenol