Effect of gonadotropin releasing hormone on ventral prostate of rat.
Testosterone induced increase in ornithine decarboxylase (ODC) activity was inhibited by simultaneous treatment with gonadotropin releasing hormone (GnRH) and its analogue in the ventral prostate of rat. Inhibition of 3H-uridine, 3H-phenylalanine and 3H-leucine incorporation into TCA precipitable material was also inhibited by GnRH in the dihydrotestosterone (DHT) treated animals. These studies further confirm that GnRH acts directly on ventral prostate and causes inhibitory effects.
D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008297:Male; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology; D014529:Uridine / Q000378:metabolism
D013196:Dihydrotestosterone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D010649:Phenylalanine; C010661:surfagon; D009955:Ornithine Decarboxylase; D007930:Leucine; D014529:Uridine