title: [Reduction of insulin reserves and exocrine pancreatic secretion in chronic pancreatitis].
abstract: In 11 persons with normal pancreas function and 21 patients with chronic pancreatitis serum levels of insulin and C-peptide were measured under basal conditions and after maximal stimulation with glucose-tolbutamide-glucagon. Patients with the highest excretory deficiency in the secretin-pancreozymin test had the most marked impairment in endocrine function. In patients with manifest diabetes the exocrine capacity was reduced to an average of 10% of normal. The endocrine parameters correlated linearly with the exocrine ones, most markedly C-peptide reserve with pancreatic enzyme secretion.
mesh_terms: D000328:Adult; D002096:C-Peptide / Q000097:blood; D002908:Chronic Disease; D002918:Chymotrypsin / Q000378:metabolism; D003920:Diabetes Mellitus / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010195:Pancreatitis / Q000150:complications / Q000503:physiopathology*; D014357:Trypsin / Q000378:metabolism
chemical_list: D002096:C-Peptide; D007328:Insulin; D002918:Chymotrypsin; D014357:Trypsin
vernacular_title: Einschränkung von Insulinreserven und exokriner Pankreassekretion bei chronischer Pankreatitis.