title: Comparative deposition of inhaled aerosols in experimental animals and humans: a review.
abstract: The biological effects of inhaled aerosols are often related to their site(s) of deposition within the respiratory tract. However, deposition patterns may differ between humans and those experimental animals commonly used in inhalation toxicology studies, making cross-species risk extrapolations difficult. This paper reviews the factors that control deposition and synthesizes much of the available data on comparative regional deposition.
mesh_terms: D000336:Aerosols; D000818:Animals; D006801:Humans; D010316:Particle Size; D011650:Pulmonary Alveoli / Q000378:metabolism; D012119:Respiration; D012137:Respiratory System / Q000033:anatomy & histology / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D000336:Aerosols