Subacute cutaneous lupus erythematosus associated with hydrochlorothiazide therapy.
Photosensitive eruptions with clinical and histologic features of subacute cutaneous lupus erythematosus and antibodies to SS-A(Ro) antigen occurred in five patients taking hydrochlorothiazide. After drug therapy was discontinued, the eruptions cleared. In one patient anti-SS-A antibodies disappeared after discontinuation of thiazide, and in another rechallenge with hydrochlorothiazide produced an acute dermatitis with a photodistribution. These eruptions may represent a new type of photosensitive drug reaction in which the photoactive drug may be synergistic with anti-SS-A antibody in producing cutaneous lesions of photosensitive subacute cutaneous lupus erythematosus.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D008179:Lupus Erythematosus, Discoid / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
D000974:Antibodies, Antinuclear; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; C035356:SS-A antibodies; D006852:Hydrochlorothiazide