[Insulin receptors of adipose tissue in patients newly diagnosed with insulin-dependent diabetes mellitus].
Binding of insulin to fatty cell plasmatic membranes in 10 patients with insulin-dependent diabetes mellitus exhibited high variability. The patients were divided into two groups based on the values of insulin binding. In the first group, comprising 3 patients, specific binding of insulin was below the values found in healthy persons; this phenomenon occurred only due to a decrease in content of insulin receptors. In the second group (7 patients) specific binding of insulin exceeded the values of controls; in this case an increase in affinity of the receptors was observed. These results suggest that insulin-dependent diabetes mellitus is characterized by high heterogeneity.
D000273:Adipose Tissue / Q000032:analysis* / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000032:analysis / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D011972:Receptor, Insulin / Q000032:analysis* / Q000378:metabolism
D007328:Insulin; D011972:Receptor, Insulin
Insulinovye retseptory zhirovoĭ tkani u vpervye diagnostirovannykh bol'nykh insulinzavisimym sakharnym diabetom.