title: Surgery and granulocyte transfusions for life-threatening infections in chronic granulomatous disease.
abstract: We report two patients with chronic granulomatous disease (CGD) and life-threatening infections: a 10 10/12-year-old boy had Aspergillus fumigatus spondylitis with destruction of the 11th vertebral body and paravertebral abscess formation, and an 8 5/12-year-old boy had multiple Staphylococcus aureus hepatic abscesses with subphrenic abscess formation. Both patients failed to respond to intense antimicrobial therapy but showed a remarkable recovery following surgical drainage combined with granulocyte transfusions. These results suggest that antimicrobial therapy and surgical drainage followed by granulocyte transfusions may be the ideal mode of treatment for severe infections in patients with CGD.
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D001803:Blood Transfusion; D002648:Child; D004338:Drug Combinations / Q000627:therapeutic use; D005437:Flucytosine / Q000627:therapeutic use; D006098:Granulocytes / Q000637:transplantation; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008100:Liver Abscess / Q000601:surgery; D008297:Male; D013166:Spondylitis / Q000628:therapy*; D013203:Staphylococcal Infections / Q000209:etiology* / Q000628:therapy; D013369:Subphrenic Abscess / Q000601:surgery; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D004338:Drug Combinations; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D005437:Flucytosine; D013420:Sulfamethoxazole