[Value of the measurement of SP1 protein in the early diagnosis of pregnancy induced with Pregnyl].
Successive dilutions of Pregnyl have been submitted to a radioimmunoassay of SP1. We have observed that Pregnyl cross-reacts with SP1. Chromatography of Pregnyl demonstrates that the contaminating substance is different from native SP1. As its concentration is low, it is however not detected in the serum of patients after the administration of exogenous Pregnyl. SP1 measurement can be helpful in detecting early pregnancies after hCG induction of ovulation.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010062:Ovulation Induction; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis / Q000097:blood*; D011863:Radioimmunoassay
D006063:Chorionic Gonadotropin; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins
Intérêt du dosage de la protéine SP1 dans le diagnostic précoce des grossesses induites par Prégnyl.