title: MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study.
abstract: Movement parameters and electromyographic (EMG) studies were carried out in two macaque monkeys performing a rapid arm movement before and after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Hypokinesia and rigidity were seen after repeated doses. Disturbances in both movements and EMG activity were similar to those reported in Parkinsonian patients.
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004195:Disease Models, Animal; D004576:Electromyography; D008253:Macaca mulatta; D009068:Movement; D009132:Muscles / Q000503:physiopathology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology; D011725:Pyridines
chemical_list: D011725:Pyridines; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine