title: [Effect of the C1q subcomponent of complement on thrombocyte adhesion and spreading].
abstract: In vitro experiments have shown that C1q at a concentration of 8-250 mkg/ml produced a 1.5-2-fold increase in platelet adhesion to glass. Low doses (4-60 mkg/ml) enhanced platelet splitting 2-3-fold. C1q did not cause platelet aggregation or change ADP-, adrenalin- and thrombin-induced aggregation. C1q participation in the induction of immune response is suggested.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D002846:Chromatography, Affinity; D003166:Complement Activating Enzymes / Q000302:isolation & purification / Q000502:physiology*; D015922:Complement C1q; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D015922:Complement C1q; D003166:Complement Activating Enzymes
vernacular_title: Vliianie C1q-subkomponenta komplementa na adgeziiu i rasplastyvanie trombotsitov.