title: Localised gamma irradiation and experimental intraocular proliferation.
abstract: A controlled study was undertaken to assess the effect of gamma irradiation on post-traumatic intraocular cellular proliferation. A standard perforating injury in the posterior segment of the rabbit eye was used to induce intraocular cellular proliferation and vitreo-retinal membrane formation. The site of injury was irradiated with an ophthalmic Cobalt60 applicator which provided a continuous source of gamma rays. Non-irradiated eyes developed traction retinal detachments associated with post-traumatic vitreo-retinal membranes. Irradiated eyes developed attenuated membranes or atrophic retinal scars, with the retina remaining attached. The membranes in non-irradiated eyes were highly cellular with abundant collagen, while irradiated membranes had fewer cells within a sparse collagen matrix. The episcleral fibroblasts, on autoradiographic studies appeared to be the main source of the cells that formed the proliferating tissue in both non-irradiated and irradiated eyes. In irradiated eyes both the inflammatory response and division of fibroblasts were delayed and reduced.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D003094:Collagen; D005123:Eye / Q000473:pathology / Q000528:radiation effects*; D005131:Eye Injuries / Q000378:metabolism / Q000473:pathology*; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D008566:Membranes / Q000473:pathology; D011817:Rabbits; D012163:Retinal Detachment / Q000517:prevention & control; D012590:Sclera / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014950:Wounds, Penetrating / Q000378:metabolism / Q000473:pathology
chemical_list: D003094:Collagen; D013936:Thymidine