title: Bleeding from stress gastritis. Has prophylactic pH control made a difference?
abstract: Control of intragastric pH with antacids or H2-receptor antagonists is a standard prophylactic treatment routinely used to prevent or control bleeding from acute erosive gastritis (AEG) in critically ill patients on trauma and surgical services. The incidence of bleeding from AEG was documented on these services retrospectively before and after the institution of standard prophylaxis treatment to determine the relative morbidity, mortality, and risk factors of each era. During the preprophylaxis and postprophylaxis era, the incidence of bleeding was the same, 2.3 per cent (13 of approximately 550 patients in each study period). Prior to prophylaxis, three times as many patients required operation (1 versus 3 patients) although the average transfusion requirement was the same (4.4 units of blood). During both eras the majority of patients were septic and showed other signs of organ failure. Inadequate prophylaxis (failure to prescribe or early discontinuation) was documented in over half of the patients who bled and in the patient requiring operation in spite of a departmental interest in stress gastritis prophylaxis. If antacids and H2-receptor antagonists are used routinely, complications from AEG should be reduced. Even with improved methods of pH control, it appears unlikely that this problem will be eliminated.
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use*; D005260:Female; D005745:Gastric Acidity Determination; D005756:Gastritis / Q000209:etiology / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control* / Q000601:surgery; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control* / Q000601:surgery; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013312:Stress, Physiological / Q000150:complications*; D014947:Wounds and Injuries / Q000150:complications
chemical_list: D000863:Antacids