Prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats.
Reported here is a description of the distribution and cellular morphology of neurons containing dynorphin B immunoreactivity (IR) and a comparison with cells containing bovine adrenal medullary peptide IR in the cerebral cortex of colchicine treated rats. Dynorphin B-IR was found in bipolar and multipolar cells in neocortical layers II-III and V-VI and in pyramidal and polymorph cells in olfactory cortical layers II and III. In the hippocampus, dynorphin B-IR was found in dentate granule cells and multipolar cells. In Fisher rats, dynorphin B was also found in cells in the subiculum and in CA1. The extensive regional overlap in the distribution of cortical neurons containing prodynorphin and proenkephalin in IR prompted a detailed comparison of their localization. In double immunostained tissue, dynorphin B-IR was demonstrated to occur in different neurons than those containing BAM22P-IR in the cerebral cortex and hippocampus of rats.
D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D009833:Olfactory Pathways / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D004745:Enkephalins; D011498:Protein Precursors; C029992:proenkephalin; D004744:Enkephalin, Methionine; C028837:BAM 22P; C033660:preproenkephalin