title: Non-specific rhinoreactivity: non-specific nasal provocation tests with methacholine and cold water solution.
abstract: The Department of Allergo-Immunology of the II ENT Division of Rome University has studied the behaviour, relative to non-specific nasal provocation with methacholine and with cold water solution, in normal subjects, in subjects with seasonal allergic rhinitis in and out of crisis, and in subjects with perennial rhinitis of allergic and non-allergic origin. All subjects underwent an ENT visit, rhinoreomanometry (RRM), mucociliary Clearance (MCT) and quantitative evaluation of nasal secretion, both before and after the single non-specific provocations. We saw that even though provocation with methacholine didn't cause a significant reduction of nasal conductance, it was the cause of noticeable modifications of the amount of nasal secretion, according to the groups taken into consideration. Furthermore, provocation with the cold water solution, which didn't provoke noticeable changes in the mucociliary clearance and in the quantity of nasal secretion, did, however cause noticeable modification of the nasal conductance in all groups examined.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003080:Cold Temperature; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D008875:Middle Aged; D009297:Nasal Mucosa / Q000502:physiology* / Q000503:physiopathology; D009299:Nasal Provocation Tests / Q000379:methods*; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000503:physiopathology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000503:physiopathology; D014867:Water
chemical_list: D008688:Methacholine Compounds; D014867:Water; D016210:Methacholine Chloride