Vitamin A effects on UMR 106 osteosarcoma cells are not mediated by specific cytosolic receptors.
Retinol and retinoic acid at 20 microM altered cell morphology and inhibited cell proliferation of UMR 106 osteosarcoma cells in culture. No specific cytosolic binding proteins for retinol could be detected.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002850:Chromatography, Gel; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D012516:Osteosarcoma / Q000378:metabolism*; D051381:Rats; D012176:Retinoids / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D012176:Retinoids; D004247:DNA; D000469:Alkaline Phosphatase; D013936:Thymidine