Lipid microspheres as novel drug carriers.
Lipid microsphere preparations of corticosteroid, non-steroid anti-inflammatory drugs and prostaglandin E1 (PGE1) all showed more potent activity than the free drugs. Lipo-PGE1 in particular was significantly more active than free PGE1 at about one-tenth the dose of free PGE1. A large mass of data obtained in studies of liposomes suggest many applications for the lipid microsphere, which is considered to be a very promising carrier in drug delivery systems.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000527:Alprostadil / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004337:Drug Carriers; D008081:Liposomes
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D003907:Dexamethasone; D000527:Alprostadil