Cardiovascular effects of intravenously given ATP-MgCl2 in canine hemorrhagic shock.
Mean arterial blood pressure, cardiac output, stroke volume and rate of left ventricular pressure rise were significantly higher in dogs given lactated Ringer's solution alone compared with dogs given lactated Ringer's solution plus intravenous ATP-MgCl2 complex. The reduced cardiac performance after intravenous ATP-MgCl2 occurred despite adequate coronary blood flow and adequate myocardial oxygen delivery. A decreased myocardial oxygen extraction and a negative myocardial lactate balance after intravenous ATP-MgCl2 indicate a cellular metabolic defect.
D000255:Adenosine Triphosphate / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001784:Blood Gas Analysis; D002319:Cardiovascular System / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption; D012039:Regional Blood Flow / Q000187:drug effects; D012151:Resuscitation; D000077325:Ringer's Lactate; D012771:Shock, Hemorrhagic / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy
D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D000255:Adenosine Triphosphate