[Acquired immunodeficiency syndrome in a child of Swiss origin whose mother died from AIDS].
Report of a now 2 8/12-year-old girl, who presented at the age of 8 months with chronic progressive pneumonia, mucocutaneous candidiasis, diarrhea, failure to thrive and a non-progressive paraplegia. The child's mother presented AIDS with pneumocystis carinii pneumonia and progressive general paralysis one year after the beginning of the child's disease and died within a few months. Additional findings in the child include lymphopenia, hyperimmunoglobulinemia, cutaneous anergy and an abnormal T helper/T suppressor cell ratio. HTLV-III antibodies were positive (ELISA and Western blot virus strip RIA). Prophylactic treatment with Co-trimoxazole relieved pulmonary infections but failure to thrive remained unchanged in spite of a continuous nutritional support. A vertical mode of transmission of AIDS from mother to child seems very probable.
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000635:transmission*; D002675:Child, Preschool; D005183:Failure to Thrive / Q000209:etiology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology; D011020:Pneumonia, Pneumocystis / Q000209:etiology; D011379:Prognosis; D013902:Radiography, Thoracic; D012141:Respiratory Tract Infections / Q000209:etiology
Erworbenes Immunmangelsyndrom bei einem Kind schweizerischer Abstammung, dessen Mutter an AIDS verstorben ist.