title: [Detection of T cell independent B cell maturation disorder in cocultivation studies in systemic lupus erythematosus].
abstract: Lymphocyte coculture experiments were performed in a case of monozygotic twins, discordant for SLE. Lack of responsiveness to T-cell-dependent and independent B-cell stimulation gave evidence of an intrinsic B-cell defect in the SLE twin.
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology*; D004200:Diseases in Twins; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M
vernacular_title: Nachweis einer T-Zell-unabhängigen B-Zellreifungsstörung in Kokultivierungsuntersuchungen beim systemischen Lupus erythematodes.