title: Human gamma-trace. Structure, function and clinical use of concentration measurements.
abstract: The discovery, tissue distribution, concentration in extracellular fluids and structure of human gamma-trace are reported. The use of determinations of the cerebrospinal fluid concentration of gamma-trace in the diagnosis of hereditary cerebral hemorrhage with gamma-trace-amyloidosis is described. The physiological function of gamma-trace as a cysteine proteinase inhibitor is accounted for an it is suggested that the six trivial names used for gamma-trace so far are replaced by the functional designation cystatin C.
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis* / Q000378:metabolism / Q000502:physiology; D055316:Cystatin C; D015891:Cystatins; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis / Q000378:metabolism / Q000502:physiology; D014018:Tissue Distribution
chemical_list: C525030:CST3 protein, human; D002556:Cerebrospinal Fluid Proteins; D055316:Cystatin C; D015891:Cystatins; D011506:Proteins