Calcitonin gene-related polypeptide as a mediator of the neurogenic ocular injury response.
Calcitonin gene-related polypeptide (CGRP) has been localised immunochemically within the rat and guinea pig anterior uvea to nerve fibres of trigeminal origin. As with substance P (1-3) the level of CGRP in the iris-ciliary body is depleted after thermal damage to the Gasserian ganglion and elevated in chronically sympathectically denervated eyes. Unlike substance P, a potent pupillary constrictor (4,5), CGRP has no notable miotic action, but does, however, cause an elevation of the intraocular pressure (IOP) accompanied by disruption of the blood-aqueous barrier. It is proposed that the diverse actions of these two sensory neuropeptides conjointly mediate the antidromic ocular injury response.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D005123:Eye / Q000294:innervation*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009479:Neuropeptides / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D014276:Trigeminal Nerve / Q000502:physiology
D009479:Neuropeptides; D015740:Calcitonin Gene-Related Peptide