title: Progressive polysystemic immune-mediated disease in a dog.
abstract: A dog with polyarthritis, angular joint deformities, and a high serum antinucleolar antibody titer was treated over a period of 20 months. During the clinical course, leukopenia, thrombocytopenia, Coombs' positive hemolytic anemia, and a pemphigus-type skin disorder developed, all of which responded to immunosuppressive therapy. It is not known whether the polysystemic disease in this dog represents a pleomorphic manifestation of canine systemic lupus erythematosus or multiple autoimmune disorders occurring in the same animal.
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D001168:Arthritis / Q000276:immunology / Q000662:veterinary; D001327:Autoimmune Diseases / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000662:veterinary*; D008297:Male
chemical_list: D000974:Antibodies, Antinuclear