Toxic epidermal necrolysis in a 6-week-old infant.
Toxic epidermal necrolysis was documented in a 6-week-old infant with Klebsiella pneumoniae sepsis who received many medications. We inoculated infant mice with the K. pneumoniae isolate but were unable to produce histologic changes resembling those seen in our patient. This condition should be included in the differential diagnosis of severe drug reactions in very young infants with clinical scalded-skin syndromes.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D004342:Drug Hypersensitivity / Q000175:diagnosis; D006349:Heart Valve Diseases / Q000150:complications; D006801:Humans; D007223:Infant; D007710:Klebsiella Infections / Q000150:complications*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D008297:Male; D051379:Mice; D011664:Pulmonary Valve; D012867:Skin / Q000473:pathology; D013203:Staphylococcal Infections / Q000150:complications; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D013997:Time Factors
D000900:Anti-Bacterial Agents