Assessment of glomerular filtration rate and effective renal plasma flow in cystic fibrosis.
A study was conducted to examine renal function in 10 healthy control subjects and eight patients with cystic fibrosis in stable condition. Sequential bolus injections of 99mTc-DTPA and 125I-OIH were administered to assess glomerular filtration rate and effective renal plasma flow, respectively. Blood was subsequently collected for 3 hours, and urine for 24 hours. Renal clearances of both radioisotope markers were virtually identical in patients and controls. Inasmuch as neither glomerular filtration rate nor effective renal plasma flow was enhanced in patients with cystic fibrosis, increased clearance of drugs in these patients is unlikely to be the result of enhanced glomerular filtration or tubular secretion.
D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000097:blood; D007668:Kidney / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology; D008433:Mathematics; D008657:Metabolic Clearance Rate; D004369:Pentetic Acid / Q000097:blood; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D013667:Technetium / Q000097:blood; D016284:Technetium Tc 99m Pentetate
D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate