title: Corrosion products from dental alloys and effects of mercuric and cupric ions on a neuroeffector system.
abstract: The release of corrosion products during long-term immersion in vitro of dental alloys, with particular reference to dissimilar alloys in contact has been studied. The effects of Hg2+ and Cu2+ in low concentrations on the guinea-pig ileum have also been studied. The following conclusions were drawn: In an aggressive solution the release of elements from amalgams could be continuous and subsurface corrosion could cause a considerable increase in the corrosion products released. The change in microstructure observed in cross-sections of the corroded specimens was related to the amounts of corrosion products released into the saline solution. In an aggressive solution the corrosion products could increase when amalgams, Co-Cr, and Ni-Cr alloys are in contact with gold alloys, a high-Cu amalgam is in contact with a conventional amalgam, a type III gold alloy is in contact with gold alloys for metallo-ceramic purposes. The high-Cu amalgams released more corrosion products into the saline solution than a conventional one. Greater quantities of corrosion products were released from amalgams at pH 4 than at pH 6. Hg2+ and Cu2+ both had diverse and dose-dependent effects on the guinea-pig ileum. In low concentrations, 10nM, both ions exerted effects, probably on the muscle cell membrane.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002858:Chromium Alloys; D003300:Copper / Q000494:pharmacology* / Q000633:toxicity; D003343:Corrosion; D003722:Dental Alloys / Q000494:pharmacology / Q000633:toxicity; D003723:Dental Amalgam; D004563:Electrochemistry; D006047:Gold Alloys; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D007082:Ileum; D008628:Mercury / Q000494:pharmacology* / Q000633:toxicity; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation; D009451:Neuroeffector Junction / Q000187:drug effects*; D012965:Sodium Chloride; D013499:Surface Properties
chemical_list: D002858:Chromium Alloys; D003722:Dental Alloys; D006047:Gold Alloys; D012965:Sodium Chloride; D003300:Copper; D003723:Dental Amalgam; D008628:Mercury