Lower 3H-imipramine binding in platelets from untreated depressed patients compared to healthy controls.
3H-Imipramine binding in platelets was measured in 63 severely depressed hospitalized patients, who had been drug free (with the exception of moderate doses of benzodiazepines) for at least 1 month, and in 53 healthy control subjects of comparable age and sex distribution. Bmax of 3H-imipramine binding was significantly lower in the depressed subjects (1012 +/- SD 295 vs. 1123 +/- SD 178 fmole/mg protein). Depressed patients who had attempted suicide by violent means tended to have higher Bmax than nonviolent attempters.
D000328:Adult; D000368:Aged; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D013406:Suicide, Attempted
D007099:Imipramine