A study on the amount of high-mobility-group chromatin proteins in T-cells at different stages of differentiation.
The amounts of high-mobility-group proteins (HMG) 1 and 2 in different mouse T-cell populations are studied. It is shown that the quantity of HMG 1 and 2 is different in functionally distinct T-cells. The level of these proteins in thymus cells is higher than in cortisone-resistant thymocytes and peripheral T-cells; it increases in the cytotoxic cells generated in mixed lymphocyte culture. The quantity of HMG is negligible in memory T-cells and increases when the latter cells are stimulated again. The differences found in the levels of HMG 1 and 2 could be related to the rate of cell proliferation and to the changes in chromatin structure at each functional stage of differentiating T-cells.
D000818:Animals; D002454:Cell Differentiation; D002843:Chromatin / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000378:metabolism*; D007156:Immunologic Memory; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D002843:Chromatin; D006609:High Mobility Group Proteins