Immunological aspects of Werner's syndrome: an analysis of 17 patients.
Several immunological assessments of the Werner syndrome are described, including detection of antibodies frequently found in autoimmune diseases and analysis of age-related changes of cell subpopulations. By using sensitive techniques such as fluorescence-activated cell sorting and solid-phase radioimmunoassay, anti-lymphocyte antibodies and anti-DNA antibodies were frequently detected in the sera from patients with the Werner syndrome. Anti-nuclear antibodies were also detected in a conventional manner; however, the titers of these antibodies were very low. Examination of cell populations revealed marked decreases in the T cell subsets reactive to both antilymphocytic antibodies and anti-brain associated T cell antigen antibodies.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002503:Centromere / Q000276:immunology; D004247:DNA / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology; D014898:Werner Syndrome / Q000276:immunology*
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007136:Immunoglobulins; D004247:DNA; D011972:Receptor, Insulin