Very low density lipoproteins in type II diabetes mellitus and risk of atherosclerosis.
Rapidly accumulation data suggest a close relation between defects in the metabolism of VLDL in type II diabetic subjects and atherogenesis in these patients. Increased concentrations of VLDL seem to be primarily due to an increased secretion of these particles. In addition, defective clearance of VLDL may be involved (e.g. impaired lipoprotein-lipase activity or an altered apolipoprotein composition of triglyceride-rich particles). VLDL and their degradation products may contribute to cholesteryl ester and triglyceride accumulation in macrophages and may affect the normal cholesterol transfer between the different lipoprotein particles or the revers cholesterol transport from peripheral cells to the liver.
D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D002788:Cholesterol Esters / Q000097:blood; D002791:Cholesterol, Dietary; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides