Effect of methionine-enkephalin plus ZnCl2 on active T cell rosettes.
Methionine-enkephalin (Met-Enk) and ZnCl2 in combination enhances active T cell rosette formation of human peripheral blood lymphocytes to a greater degree than either of the agents used separately. Enhancement of rosette formation by Met-Enk plus ZnCl2 was not inhibited by the opiate receptor antagonist naloxone but was completely blocked by the zinc chelator 1,10-phenanthroline. The results suggest a relationship between zinc and Met-Enk and that zinc may be a modulator of enkephalin binding and function in the immune system as well as the nervous system.
D002712:Chlorides; D004357:Drug Synergism; D004744:Enkephalin, Methionine / Q000494:pharmacology*; D006801:Humans; D009270:Naloxone / Q000494:pharmacology; D010618:Phenanthrolines / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*; D017967:Zinc Compounds
D002712:Chlorides; D010618:Phenanthrolines; D017967:Zinc Compounds; D009270:Naloxone; D004744:Enkephalin, Methionine; C016837:zinc chloride; D015032:Zinc