title: [Pigment and ion transport in the vestibular organ].
abstract: Pigments are found in various parts of the inner ear, especially in the neighbourhood of epithelia, which are supposed to be involved in the secretion and/or absorbtion of the endolymphatic fluid. Microprobe analysis (laser absorption mass micro analyzer "LAMMA" and X-ray) combined with morphological observations were performed in shock frozen, freeze-dried and plastic embedded inner ear tissue from the vestibular organ of pigmented guinea pig. Disturbance of the endolymphatic ionic composition (increased Na+) due to treatment with metabolic inhibitors (ethacrynic acid, ouabain) stimulated the migration of pigment granules and displacement of the dentritic processes of the melanocytes in a close vicinity to the presumably transporting vestibular epithelia (the dark and light cells and capillaries). The melanosomes obtained full range of metal ions that changed characteristically after treatment with metabolic inhibitors. It could be supposed that melanin presents some kind of reservoir for essential trace elements or compounds and may regulate numerous enzymatic and membrane functions by binding and releasing the metal ions.
mesh_terms: D000818:Animals; D004573:Electrolytes / Q000378:metabolism; D004710:Endolymph / Q000378:metabolism; D004848:Epithelium / Q000033:anatomy & histology; D004976:Ethacrynic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000648:ultrastructure; D010042:Ouabain / Q000494:pharmacology; D012444:Saccule and Utricle / Q000033:anatomy & histology; D014722:Vestibule, Labyrinth / Q000033:anatomy & histology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D004573:Electrolytes; D008543:Melanins; D010042:Ouabain; D004976:Ethacrynic Acid
vernacular_title: Pigment und Ionentransport im Vestibularorgan.