[Thymosin restoration of the interferon-synthesizing capacity of the splenocytes in mice undergoing stress exposure].
Direct correlation was established between changes in the activity of natural killers and capacity of lymphocytes for interferon synthesis after stress was demonstrated. Thymosin was found to enhance interferon synthesis in response to induction with NDV, PHA, and SEA in the period of marked inhibition of splenocyte function as a result of stress. The phenomenon of restoration by thymosin of the capacity of splenocytes in the post-stress phase to synthesize interferon in response to induction was also established in vivo.
D000818:Animals; D007369:Interferon Inducers / Q000494:pharmacology; D007370:Interferon Type I / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013947:Thymosin / Q000494:pharmacology*; D013997:Time Factors
D007369:Interferon Inducers; D007370:Interferon Type I; D013947:Thymosin
Vosstanovlenie timozinom interferonsinteziruiushcheĭ sposobnosti splenotsitov mysheĭ, perenesshikh stressornye vozdeĭstviia.