The effect on pregnancy of intrauterine administration of antibodies against two pregnancy-associated murine proteins: murine pregnancy-specific beta 1-glycoprotein and murine pregnancy-associated alpha 2-glycoprotein.
Intrauterine administration of 100 arbitrary units (AU) of purified monospecific rabbit anti murine pregnancy specific beta 1-glycoprotein antibodies resulted in the loss of the fetuses in pregnant mice (14 out of 14). By contrast, a similar treatment with 100 AU of rabbit anti murine pregnancy-associated alpha 2-glycoprotein had an effect similar to saline on the outcome of pregnancy. Intravenous administration of 1000 AU of rabbit anti murine pregnancy specific beta 1-glycoprotein during pregnancy in mice had no effect on the outcome of pregnancy.
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005327:Fetal Resorption / Q000209:etiology*; D005865:Gestational Age; D007275:Injections, Intravenous; D051379:Mice; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000502:physiology; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000037:antagonists & inhibitors / Q000276:immunology* / Q000502:physiology; D014327:Trophoblasts / Q000502:physiology; D014599:Uterus
D000906:Antibodies; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins