title: Lack of effect of indomethacin on systemic and splanchnic haemodynamics in portal hypertensive rats.
abstract: Portal hypertension was produced experimentally in rats by partial constriction of the portal vein. Twelve rats were injected daily with indomethacin, 4 mg/kg body weight, and 12 with the vehicle (80% ethanol, 0.5 ml/day). There were no differences in portal-systemic shunts nor systemic or splanchnic haemodynamics between indomethacin-treated and untreated rats. These results suggest that cyclo-oxygenase products do not play a significative role in haemodynamic alterations shown by portal-ligated rats.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000652:urine; D000818:Animals; D015232:Dinoprostone; D006439:Hemodynamics / Q000187:drug effects*; D006975:Hypertension, Portal / Q000378:metabolism / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology*; D011458:Prostaglandins E / Q000652:urine; D051381:Rats; D012083:Renin / Q000097:blood; D013152:Splanchnic Circulation / Q000187:drug effects*
chemical_list: D011458:Prostaglandins E; D015121:6-Ketoprostaglandin F1 alpha; D012083:Renin; D015232:Dinoprostone; D007213:Indomethacin