title: The measured effect of phenytoin withdrawal on gingival hyperplasia in children.
abstract: Gingival enlargement was studied and measured in ten patients before, and for 18 months after discontinuation of phenytoin therapy. A clinically evident decrease in gingival hyperplasia occurred after discontinuing phenytoin in all subjects; all subjects, however, had mild hyperplasia after 18 months. These results may encourage increased use of alternative antiseizure drugs.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003774:Dental Plaque Index; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D005888:Gingival Pocket / Q000473:pathology; D006801:Humans; D008297:Male; D010512:Periodontal Index; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D010672:Phenytoin