Pancreas preservation with TP-IV: a hyperosmolar colloid solution.
This study compares the efficacy of a new hyperosmolar colloid solution (TP-IV) with Euro-Collins solution for long-term (72 hr) hypothermic storage of canine pancreas autografts. Four experimental recipient groups and their survival (30-day study period) results were as follows: Gr. I (n = 6) pancreatectomized controls, without autotransplant (X +/- SD = 5.83 +/- 3.06 days); Gr. II (n = 6) fresh nonpreserved autografts (X +/- SD = 23.83 +/- 10.12 days, 5 of 6 greater than 30 days); and Gr. III (n = 7) and Gr. IV (n = 5) receiving pancreas autografts stored at 4 degrees C for 72 hr in either Euro-Collins or TP-IV, respectively (Gr. III, 13.85 +/- 9.04 days; Gr. IV, 21.2 +/- 12.37 days). The results appear to indicate that TP-IV is superior to Euro-Collins solution for 72-hr hypothermic storage of pancreas grafts. In fact, survival in the TP-IV-presented group was comparable to that of fresh, non-preserved autografts.
D000818:Animals; D003080:Cold Temperature; D003102:Colloids; D004285:Dogs; D006085:Graft Survival; D006982:Hypertonic Solutions; D009926:Organ Preservation / Q000379:methods*; D010179:Pancreas / Q000033:anatomy & histology / Q000502:physiology; D016035:Pancreas Transplantation; D014182:Transplantation, Autologous
D003102:Colloids; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions