Long-term effect of diabetes and pregnancy in the rat.
Islet hyperplasia and B-cell degranulation were found in the fetuses of the third generation from mothers (second generation) born to a diabetic mother (first generation) regardless of the origin of the father, while pancreatic islets were normal in fetuses from control mothers, even when the father was an offspring of a diabetic mother. These data support the hypothesis that in our experimental model overstimulation of the fetal endocrine pancreas results in long-term consequences to the third generation.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005333:Fetus / Q000033:anatomy & histology; D007515:Islets of Langerhans / Q000196:embryology; D008297:Male; D010179:Pancreas / Q000196:embryology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose