title: Propofol ('Diprivan') by intermittent bolus with nitrous oxide in oxygen for body surface operations.
abstract: The use of propofol for induction and maintenance of anaesthesia by intermittent bolus injection in 37 patients undergoing body surface operations is described. This technique gave good operating conditions in most of the patients in the series. With an induction dose of 2.5 mg/kg propofol, a dose of 11.25 mg/kg/h was found to be the median dose requirement for maintenance of anaesthesia in this study. This dose will be used to calculate infusion rates for future studies with the drug.
mesh_terms: D000759:Adjuvants, Anesthesia; D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001049:Apnea / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010100:Oxygen; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects; D015742:Propofol
chemical_list: D000759:Adjuvants, Anesthesia; D010636:Phenols; D009609:Nitrous Oxide; D010100:Oxygen; D015742:Propofol