Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats.
Pentostatin (2'-deoxycoformycin), a potent inhibitor of adenosine deaminase, was administered therapeutically to rats with type II collagen-induced arthritis and the effects on hindpaw swelling, serum haptoglobin concentration, and anticollagen antibody titer determined. Daily intraperitoneal administration of pentostatin at 10.0 or 1.0 mg/kg/day for three weeks produced significant enhancement of hind-paw swelling and elevation of serum haptoglobin. Continuous subcutaneous infusion of pentostatin at 1.0 or 0.1 mg/kg/day had the same effects. None of the dosing regimens had any effect on anticollagen antibody titer.
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D000906:Antibodies / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology*; D003070:Coformycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D003094:Collagen / Q000276:immunology; D006242:Haptoglobins / Q000032:analysis; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D015649:Pentostatin; D051381:Rats; D012263:Ribonucleosides / Q000494:pharmacology*
D058892:Adenosine Deaminase Inhibitors; D000906:Antibodies; D006242:Haptoglobins; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin; D003094:Collagen; D009700:Nucleoside Deaminases