Mutagenicity in the Salmonella/microsome assay of tobacco condensates formed during pipe smoking.
The condensates collected after pipe smoking of a natural tobacco and a cavendish type tobacco, either unwrapped or wrapped in a paper "saver" bag, were tested for mutagenicity in the Salmonella/mammalian microsome assay with strains TA100 and TA98. The number of revertants induced with cavendish type tobacco in the presence of metabolic activation (mouse-liver S9) was higher in both strains compared to the natural tobacco. Further increase in the number of revertants (approx. 3 times) was consistently seen when the tobacco was smoked after paper wrapping "savers".
D000818:Animals; D001711:Biotransformation; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000235:genetics*; D012907:Smoking; D014026:Nicotiana
D009153:Mutagens