Structural adaptation to altered electrolyte metabolism by cortical distal segments.
The four different renal cell types in the cortical segments beyond the macula densa--distal convoluted tubule (DCT) cell, the connecting tubule (CNT) cell, the principal (P) cell, and the intercalated (I) cell--each respond to prolonged specific stimuli with changes in cell membrane area. Increases in basolateral cell membrane area, reflecting the transport capacity of the cell, are associated in DCT cells with luminal, chronically high sodium load, in CNT cells with mineralocorticoids and tubular solute load, and in P cells with mineralocorticoids. In I cells the luminal cell membrane area seems to be influenced by the local luminal environment of the cells as well as by the peritubular environment. These structural findings indicate that tubular fluid composition as well as peritubular factors (e.g., mineralocorticoid levels) may have a role in regulating the transport capacity of distal cell types in the kidney.
D000222:Adaptation, Physiological; D000818:Animals; D001693:Biological Transport, Active; D002450:Cell Communication; D002462:Cell Membrane / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism*; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D007672:Kidney Cortex / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D007684:Kidney Tubules / Q000166:cytology*; D007685:Kidney Tubules, Collecting / Q000166:cytology / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000166:cytology* / Q000378:metabolism / Q000502:physiology; D051381:Rats
D004573:Electrolytes