The effects of d-propranolol and captopril on post-ischaemic acute renal failure in rats.
The effect of the combined therapy of d-propranolol and captopril was evaluated in post-ischaemic acute renal failure in rats. The glomerular filtration rate measured 24 hours after ischaemic insult in the animals receiving no drugs was 54 +/- 11 microliter/min/100g body weight while in animals treated with the combination of d-propranolol and captopril it was 305 +/- 35 microliter/min/100g body weight (p less than 0.05). The precise mechanism of protection afforded by the combination therapy is not clear, but this approach could be useful in protecting the kidney from ischaemic damage.
D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D002216:Captopril / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D011433:Propranolol / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D011392:Proline; D002216:Captopril; D011433:Propranolol