Optimal timing of adjuvant chemotherapy in mouse models.
In three mouse tumor models the effect of timing of adjuvant chemotherapy with a single dose of cyclophosphamide was studied. In one tumor, preoperative adjuvant therapy was better than postoperative therapy. In a second tumor, the reverse was the case, and in the third model there was no difference resulting from variation in the timing of cytostatic drug therapy. Obviously, the concept that a standard drug dose always gives a constant relative cell kill is not always a valid simplification of dose-effect relationships in chemotherapy.
D000818:Animals; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D008175:Lung Neoplasms / Q000188:drug therapy / Q000601:surgery; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000601:surgery; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000601:surgery; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery; D013997:Time Factors