Salmonella/microsome mutagenicity of monochloro derivatives of some di-, tri- and tetracyclic aromatic hydrocarbons.
A series of 8 monochloroarenes have been tested for mutagenicity in the Salmonella/microsome assay. None of the compounds was detectably active in the absence of mammalian activation whereas, depending on structure, some of the compounds were mutagenic in its presence having responses higher than those reported for the parent compounds.
D000818:Animals; D001711:Biotransformation; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D011083:Polycyclic Compounds / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D006843:Hydrocarbons, Chlorinated; D011083:Polycyclic Compounds