High serum levels of alkaline phosphatase are associated with cancer in cholestatic jaundice.
In a prospective study of liver function tests in cholestatic jaundice, the median serum level of alkaline phosphatase (ALP) in 129 patients with cancer involving extrahepatic ducts and liver (556 IU/1) was significantly higher (P less than 0.001) than that in 121 patients without cancer (264 IU/1). Of patients with an ALP level of greater than 10 X N, 88% had cancer whereas serum levels of ALP of less than 3 X N were observed in only 9% of patients with cancer but in 45% of those without cancer, most of whom had bile duct stones. A high serum level of ALP is associated with cancer involving extrahepatic ducts and liver.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D001650:Bile Duct Neoplasms / Q000150:complications / Q000201:enzymology*; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000201:enzymology / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000201:enzymology*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000201:enzymology; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin