title: Pharmacological principles of treatment in diabetes.
abstract: Although a number of improvements in medical care have led to an overall improvement in the prognosis of diabetes, there have been few major new developments in the pharmacological management of diabetes mellitus apart from the introduction of insulin in the 1920s and of orally administered hypoglycaemic agents in the 1950s. However, recent developments in our knowledge of the aetiology of diabetes and its complications may herald a new era in the management of diabetes with specific approaches to the prevention or reversal of diabetes and its complications.
mesh_terms: D001645:Biguanides / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D007165:Immunosuppression Therapy; D007328:Insulin / Q000627:therapeutic use; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
chemical_list: D001645:Biguanides; D007328:Insulin; D013453:Sulfonylurea Compounds