Atherosclerosis as an inflammatory process. The roles of the monocyte-macrophage.
In this brief review, we have addressed the roles of the monocyte-macrophage in atherogenesis, with emphasis on the recruitment to the arterial wall. We have presented summary data on the SMC-derived chemoattractant protein and also on the temporal evolution of monocyte-derived macrophages into cholesteryl ester-rich foam cells. The concept of atheroma as an inflammatory process has also been discussed.
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology* / Q000503:physiopathology; D002630:Chemotactic Factors / Q000502:physiology; D004195:Disease Models, Animal; D004727:Endothelium / Q000473:pathology; D005487:Foam Cells / Q000473:pathology / Q000502:physiology; D066298:In Vitro Techniques; D007249:Inflammation / Q000473:pathology* / Q000503:physiopathology; D008264:Macrophages / Q000473:pathology* / Q000502:physiology; D009000:Monocytes / Q000473:pathology* / Q000502:physiology; D010215:Papio; D010587:Phagocytosis; D011817:Rabbits
D002630:Chemotactic Factors