Lymphocyte chemotaxis in inflammation. X. Heterogeneity of chemotactic responsiveness in human T subsets towards lymphocyte chemotactic factors from delayed hypersensitivity reaction site.
In previous studies, four lymphocyte chemotactic factors (LCF-a, -b, -c and -d) were isolated from delayed-type hypersensitivity (DTH) skin reaction sites of guinea-pig. In tests on guinea-pig lymphocytes, LCF-a attracted B cells, whereas LCF-b, -c and -d attracted T cells. We now report the chemotactic responses of human lymphocytes to the guinea-pig LCFs. LCF-a strongly attracted B lymphocytes and weakly attracted T lymphocytes, whereas LCF-b, -c and -d predominantly attracted T lymphocytes. In tests on T-lymphocyte subsets, LCF-b and -d selectively attracted OKT4 subsets and theophylline-resistant T cells with helper phenotype. In contrast, LCF-c attracted OKT4 and OKT8 subsets, and both theophylline-resistant and sensitive subsets (i.e. cells with both helper and suppressor phenotype). The results indicate that the different T-cell subsets migrate selectively into sites of inflammation.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D019744:Chemokines, C; D002634:Chemotaxis, Leukocyte; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D012795:Sialoglycoproteins / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D019744:Chemokines, C; D008222:Lymphokines; D012795:Sialoglycoproteins; C092390:XCL1 protein, human; C018997:lymphotactin