Mutagenic effects of thiram in mammalian somatic cells.
The dimethylthiocarbamate fungicide thiram has been found to be a potent and direct inducer of point mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster cells in vitro. It also increased the incidence of micronuclei in polychromatic erythrocytes in the bone marrow of mice given a single ip dose of 100 mg/kg. Both the in vitro and the in vivo mutagenic responses were observed with doses of thiram that were cytotoxic.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics; D013859:Thiocarbamates / Q000633:toxicity*; D013893:Thiram / Q000633:toxicity*
D009153:Mutagens; D013859:Thiocarbamates; D013893:Thiram; D007041:Hypoxanthine Phosphoribosyltransferase