Pathogenesis of acute and chronic lung injury induced by foreign compounds.
The lung may become damaged by both airborne or bloodborne agents. Mechanisms implicated in the pathogenesis of lung injury include formation of highly reactive metabolites formed by pulmonary mixed function oxidases or formation of free oxygen radicals. Acute and chronic damage can be evaluated by several methods, such as histology and quantitative morphometry, non-invasive and non-destructive respiratory function tests, and with biochemical techniques that include measuring lavage enzyme levels or quantitating the presence of macromolecules such as collagen. In addition, cell kinetics provide an additional method to explore events following lung damage.
D000208:Acute Disease; D000393:Air Pollutants / Q000009:adverse effects; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D001711:Biotransformation; D002908:Chronic Disease; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced* / Q000378:metabolism; D010269:Paraquat / Q000009:adverse effects / Q000378:metabolism
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D010269:Paraquat