Significance of placental findings in early-onset group B streptococcal neonatal sepsis.
Assessment of placental pathology and its relationship to historical data, initial laboratory parameters, and outcome was undertaken in 22 cases of early-onset group B streptococcal sepsis of the neonate. Fourteen (64%) of the placentas demonstrated chorioamnionitis, six (27%) funisitis, and in nine (41%) gram stain demonstrated organisms within the membranes. Focal villous edema was observed in five (23%) cases and diffuse villous edema in four (18%). No placenta demonstrated chorangiosis. Placental inflammation was significantly (p less than 0.05) associated with prematurity, prolonged rupture of membranes, and onset of symptoms at less than 3 hours of age. No placental change was significantly associated with outcome or with neutropenia, which was the only parameter assessed that appeared to have prognostic value.
D002821:Chorioamnionitis / Q000209:etiology; D004487:Edema / Q000209:etiology; D005321:Extraembryonic Membranes / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000209:etiology; D008297:Male; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000209:etiology; D011247:Pregnancy; D012737:Sex Factors; D013290:Streptococcal Infections / Q000209:etiology*; D013292:Streptococcus agalactiae; D013997:Time Factors; D014470:Umbilical Cord / Q000473:pathology