title: Variations in the organization of repetitive DNA sequences in the genomes of Plasmodium falciparum clones.
abstract: Repetitive DNA in cultured Plasmodium falciparum was examined by restriction digestion and transfer hybridization, using cloned repetitive DNA probes. The arrangement of repetitive DNA was unstable: after 6 months culture of a cloned population, variations could be detected. Significant differences can be seen between clones derived from a single isolate, and are even more marked between isolates of diverse geographical origin. No cross-species conservation was seen for the sequences examined, and no relationship was observed between their representation in the P. falciparum genome and the potential for sexual differentiation.
mesh_terms: D000818:Animals; D002999:Clone Cells; D004247:DNA / Q000032:analysis* / Q000235:genetics; D005796:Genes; D010963:Plasmodium falciparum / Q000032:analysis* / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid; D013045:Species Specificity; D014158:Transcription, Genetic
chemical_list: D004247:DNA