title: The effects of terodiline and meladrazine on severe motor urge incontinence in geriatric patients.
abstract: Twenty-five geriatric patients with severe motor urge incontinence were treated with terodiline and meladrazine separately and in combination. Because of poor general state of health and serious concomitant diseases the frequency of dropouts was high. Separate administration of the drugs improved the majority of the patients subjectively, but not sufficient for complete continence. Urodynamically, however, significant improvement was found only with terodiline. On combined administration with both drugs, seven of 15 patients became completely continent, seven were improved, and one remained unchanged, but additional urodynamic improvement was not demonstrated. Meladrazine caused a high incidence of side effects; therefore, treatment with terodiline separately is recommended for geriatric patients who have severe motor urge incontinence.
mesh_terms: D000368:Aged; D002082:Butylamines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014227:Triazines / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000187:drug effects; D014549:Urinary Incontinence / Q000188:drug therapy*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D002082:Butylamines; D014227:Triazines; C005040:meladrazine; C010637:terodiline