Gc (vitamin D binding protein) subtypes in rheumatoid arthritis.
Two hundred and six patients with rheumatoid arthritis were examined for their association with the subtypes of Gc (vitamin D binding protein). In patient groups there is 11% excess of individuals with Gc*2 allele compared to the control group, giving a relative risk of 1.55. This risk increases with the humoral status of the individual. A possible physiological basis between the association of vitamin D binding protein and rheumatoid arthritis is discussed.
D000328:Adult; D000483:Alleles; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012217:Rheumatoid Factor / Q000032:analysis; D012306:Risk; D012698:Serologic Tests; D014809:Vitamin D-Binding Protein / Q000235:genetics*
D000974:Antibodies, Antinuclear; D014809:Vitamin D-Binding Protein; D012217:Rheumatoid Factor