Differences in the binding, internalization and catabolism of low-density lipoprotein between normal human T and B lymphocytes.
Studies in human peripheral blood B and T lymphocytes show that high-affinity binding of low-density lipoprotein (LDL) to the cell surface receptor and the kinetics of binding are comparable between B and T lymphocytes, but the internalization of receptor-bound LDL in B cells appears deficient. Yet, the fraction of internalized LDL degraded by both B and T lymphocytes is of similar magnitude. Moreover, the lysosomal acid cholesterol ester hydrolase and acyl-CoA:cholesterol acyltransferase activities in B cell were about one-third of those in T lymphocytes. These data suggest deficient LDL catabolism in B lymphocytes relative to that in T lymphocytes.
D001402:B-Lymphocytes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D011485:Protein Binding; D011973:Receptors, LDL / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D002787:Sterol Esterase / Q000378:metabolism; D002785:Sterol O-Acyltransferase / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism
D008077:Lipoproteins, LDL; D011973:Receptors, LDL; D012710:Serum Albumin, Bovine; D002785:Sterol O-Acyltransferase; D002787:Sterol Esterase