Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate.
The susceptibility of newborn mice to the inception of tolerance after exposure to antigen is associated with their deficiency in the production of endogenous interleukin 2 (IL-2). As further evidence of the complicity of IL-2 in the inception and maintenance of tolerance, it is shown here that a solid and long-lasting state of tolerance induced by the intravenous injection into newborn CBA mice of lymphoid cells from (CBA X C57BL/10ScSn)F1 hybrids can be brought to an end by the administration of exogenous IL-2 or by supplementing an otherwise normal diet with vitamin A acetate, the effect of which is to increase the proportion of the moiety of the T-cell population that produces IL-2. These results indicate that certain nonspecific stimuli can influence whether immunological tolerance is maintained.
D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D007108:Immune Tolerance / Q000187:drug effects*; D007376:Interleukin-2 / Q000494:pharmacology*; D007519:Isoantigens / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008970:Molecular Weight; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014801:Vitamin A / Q000494:pharmacology*
D007376:Interleukin-2; D007519:Isoantigens; D014801:Vitamin A