Chromogenic peptide substrate assays for determining components of the plasma kallikrein system.
Methods for plasma prekallikrein, kallikrein like activity, kallikrein inhibitors and inhibitors of beta FXIIa using chromogenic peptide substrates are outlined. Results with these assays are described and discussed. Substrates for alpha and beta FXIIa are also described and the possibilities of a direct chromogenic substrate assay for FXII are discussed.
D000799:Angioedema / Q000097:blood; D001779:Blood Coagulation Factors / Q000032:analysis; D002863:Chromogenic Compounds; D005175:Factor XII Deficiency / Q000097:blood; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000032:analysis* / Q000037:antagonists & inhibitors; D007700:Kinetics; D008103:Liver Cirrhosis / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood; D011247:Pregnancy; D011288:Prekallikrein / Q000032:analysis*; D012016:Reference Values
D001779:Blood Coagulation Factors; D002863:Chromogenic Compounds; D011288:Prekallikrein; D007610:Kallikreins