Mutagenicity of 1,2-dichloroethane and 1,2-dibromoethane in two human lymphoblastoid cell lines.
1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) were tested for the ability to induce gene mutations in two human lymphoblastoid cell lines, designated AHH-1 and TK6. Both chemicals were 'direct-acting' mutagens in both cell lines. DBE was essentially equally mutagenic in TK6 cells and AHH-1 cells. In contrast, DCE was 25-fold more mutagenic in the AHH-1 cell line than in the TK6 cell line. This differential sensitivity between AHH-1 cells and TK6 cells was related to the levels of glutathione S-transferase activity in these two cell lines.
D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015946:Ethylene Dibromide / Q000633:toxicity*; D005025:Ethylene Dichlorides / Q000633:toxicity*; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008214:Lymphocytes / Q000187:drug effects*; D009154:Mutation / Q000187:drug effects*
D005025:Ethylene Dichlorides; D006842:Hydrocarbons, Brominated; D006843:Hydrocarbons, Chlorinated; D015946:Ethylene Dibromide; D007041:Hypoxanthine Phosphoribosyltransferase