title: Blood loss following dental extractions in anticoagulated rabbits: effects of tranexamic acid and socket packing.
abstract: The present study demonstrates the feasibility of chronic anticoagulation in rabbits and of estimating the resulting increase in blood loss following extraction of four front teeth from labeled red cell disappearance curves. This setup proved useful for the evaluation of hemostatic techniques. Socket packing with oxidized cellulose soaked in thrombin solution or local application of cyanobutylacrylate reduced early blood loss; oral administration of tranexamic acid reduced both early and late bleeding; the combination of socket packing and oral tranexamic acid completely abolished the excessive blood loss that resulted from anticoagulation alone.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001458:Bandages; D002483:Cellulose, Oxidized / Q000008:administration & dosage / Q000627:therapeutic use; D002860:Chromium Radioisotopes; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004659:Enbucrilate / Q000008:administration & dosage / Q000627:therapeutic use; D004912:Erythrocytes / Q000166:cytology; D006472:Oral Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D011817:Rabbits; D013917:Thrombin / Q000008:administration & dosage / Q000627:therapeutic use*; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D002483:Cellulose, Oxidized; D002860:Chromium Radioisotopes; D003509:Cyclohexanecarboxylic Acids; D014859:Warfarin; D014148:Tranexamic Acid; D003094:Collagen; D013917:Thrombin; D004659:Enbucrilate