Variation in human platelet 3H-imipramine binding.
Platelet 3H-imipramine binding values from 45 normal controls and 20 depressed subjects were collected over a 2-year period. During this time, wide inter-individual variations in the affinity constant (Kd) and maximal number of binding sites (Bmax) were observed in the control population; however, we failed to observe a seasonal change in platelet 3H-imipramine binding. The Kd and Bmax values of depressed subjects were not significantly different from those of controls.
D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood*; D014644:Genetic Variation; D006801:Humans; D007099:Imipramine / Q000097:blood*; D008137:Longitudinal Studies; D012621:Seasons
D007099:Imipramine