Preferential paternal transmission of the diabetogenic supratype marked by HLA B18 BfF1 DR3.
Examination of transmission of the diabetogenic supratype B18 BfF1 DR3 revealed that this supratype is inherited more frequently than expected from fathers. These data suggest an explanation for increased susceptibility to development and earlier onset of insulin dependent diabetes mellitus in offspring of diabetic fathers.
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D012737:Sex Factors
D006680:HLA Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; C040610:HLA-BfF1 antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II