C-peptide-like material in rat brain: response to fasting and glucose ingestion.
Because of controversial data on the presence of insulin in the central nervous system, the presence of C-peptide immunoreactivity was followed in acid/ethanol extracts of the rat brain. C-peptide-like material was detected in whole brain extracts as well as in several brain fragments. Immunoreactive C-peptide concentrations were significantly higher in hypothalamus and olfactory bulb as compared to those in other brain regions sampled. Fasting for 72 h resulted in a decrease and oral glucose administration (0.75-1.5 g given in form of 25% water solution 30 min before sacrifice) was followed by an increase of C-peptide-like immunoreactivity in both plasma and hypothalamus.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D002096:C-Peptide / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005215:Fasting; D005947:Glucose / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002096:C-Peptide; D004040:Dietary Carbohydrates; D005947:Glucose