Inhibition by cyclosporin A of IgE production and cyclophosphamide-induced eosinophilia in rats immunized with non-parasite antigens.
Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production but at the same time induced a striking eosinophilia. Combined administration of both drugs resulted in the inhibition by CS-A of the Cy-induced eosinophilia. The results suggest that IgE synthesis and eosinophil proliferation may be under the control of separate T cell subsets. This rat model may prove useful in studies on the regulation of eosinophil production and the role of these cells in disease processes.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology*; D004802:Eosinophilia / Q000209:etiology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis*; D010047:Ovalbumin / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D003524:Cyclosporins; D007073:Immunoglobulin E; D003520:Cyclophosphamide; D010047:Ovalbumin