Successful transplantation of soy bean agglutinin-fractionated, histoincompatible, maternal marrow in a patient with severe combined immunodeficiency and BCG infection.
A successful transplantation of soybean agglutinin (SBA) and sheep red blood cell (SRBC)-fractionated, maternal marrow in a patient with severe combined immunodeficiency (SCID) is reported. The engraftment of HLA-haplotype mismatched marrow cells was obtained without apparent graft versus host disease (GVHD). With immunological reconstitution the patient recovered from a BCG infection, which might have been caused by a BCG inoculation before his bone marrow transplantation.
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006082:Graft Enhancement, Immunologic / Q000379:methods*; D006084:Graft Rejection; D006680:HLA Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D007223:Infant; D037102:Lectins / Q000494:pharmacology; D008297:Male; D037121:Plant Lectins; D012397:Rosette Formation; D030262:Soybean Proteins; D013025:Glycine max; D014376:Tuberculosis / Q000188:drug therapy / Q000209:etiology*; D010835:Phytohemagglutinins
D000995:Antitubercular Agents; D001500:BCG Vaccine; D006680:HLA Antigens; D037102:Lectins; D037121:Plant Lectins; D030262:Soybean Proteins; C028824:soybean lectin; D010835:Phytohemagglutinins