Dissemination pattern of two immunologically induced transplanted malignant lymphomas in C57 B1/6J mice.
The need for syngenic tumors to elucidate factors in lymphoma dissemination prompted us to induce new lymphomas in a series of inbred C57B1/6J mice. The method of induction, immunosuppression and simultaneous immunostimulation, had a high mortality rate, but gave us 2 transplantable lymphomas. These tumors are described and compared in the present paper, with emphasis on their dissemination patterns. Both tumors disseminated rapidly from tail transplants to lymphoid organs, lungs and liver. They were characteristically dissimilar, however, in their s.c., i.p. and i.v. transplantabilities.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D005620:Freund's Adjuvant; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014185:Transplantation, Isogeneic
D007106:Immune Sera; D005620:Freund's Adjuvant