T-cell acute lymphoblastic leukemia: a report of 60 patients from India.
60 patients studied at the Tata Memorial Hospital from January 1976 to December 1982 were diagnosed as having T-cell acute lymphoblastic leukemia (ALL) by nonimmune rosette formation with sheep red blood cells. The analysis revealed a high incidence of mediastinal mass (50%) and extramedullary infiltration at presentation. The majority of patients (62%) presented with a high WBC count (greater than 50,000/mm3). Unipolar acid phosphatase activity was observed in 90% of patients. The remission rate with a combination treatment of adriamycin, vincristine and prednisolone was found to be 95%. Long-term survival was around 30%. More aggressive or innovative treatments will be needed to improve the results in T-cell ALL.
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D007945:Leukemia, Lymphoid / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology