title: High-dose corticosteroids in thoracic trauma.
abstract: Experimental data show that lung injury may be prevented or reduced when steroids are administered early. It seems, however, difficult to reverse a lung injury which is already established. Accordingly, we have since 1976 administered high doses of methylprednisolone already on admission in patients with multiple rib fractures and/or flail chest (30 mg/kg i.v. X 3 at 8 hr intervals). A retrospective analysis of 143 patients with severe blunt chest trauma, most of whom were multitraumatized (72%) and many in shock (19%) revealed a significantly lower mortality for 44 steroid treated patients compared to 99 nonsteroid patients with similar injuries (9.1 vs 29.3%, p = 0.02). The incidence of bronchial infection and septicemia was not increased in steroid treated patients. There was also a lower incidence of multiple organ failure in the steroid treated group (4.5%) as compared to the control group (9.1%, n.s.). Hemodynamic and blood gas changes were examined in a prospective controlled study including 40 patients with multiple rib fractures and lung contusion. Pulmonary vascular resistance (PVR), which is a good parameter of injury severity, was reduced significantly in the steroid treated group. This led to a reduction in right heart work. The corticosteroid induced reduction in PVR was seen whether the patient was on a ventilator or breathed spontaneously. There were no significant differences in the a-v oxygen difference or in intrapulmonary shunting. Both the number of complications and the duration of artificial respiration were reduced in the steroid group.
mesh_terms: D005260:Female; D005409:Flail Chest / Q000150:complications; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D055370:Lung Injury; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D009102:Multiple Organ Failure; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000187:drug effects; D012189:Retrospective Studies; D012253:Rib Fractures / Q000150:complications; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D013898:Thoracic Injuries / Q000150:complications*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D010100:Oxygen; D008775:Methylprednisolone