A comparative study of once versus twice daily treatment of superficial dermatophyte and yeast infections with tioconazole (1%) cream.
Two open, multicentre studies were performed to evaluate the efficacy of 1% tioconazole cream (Trosyd, Pfizer) as a once daily treatment for patients with common superficial dermatophyte and yeast infections (t. pedis, t. versicolor, t. corporis, t. cruris, candidiasis). In Study I, forty-eight patients were treated once daily and forty-nine were treated twice daily. The clinical response rate at the last treatment visit was 96% and 98%, respectively, in the two treatment groups. In Study II, all 107 patients were treated once daily, and the clinical response rate was 95% at the last treatment visit. The mycological cure rates were 85% and 91% in the Study I groups, and 94% in Study II. At the long-term follow-up evaluation (approximately 4 weeks after treatment) favourable clinical responses were seen in 88% of patients in both the Study I groups, and in 94% of patients in Study II. Long-term mycological cures were seen in 80% of patients in both groups of Study I, and in 94% of patients in Study II. Side-effects of treatment were generally transient, mild and coincident with disease symptoms, and occurred in six patients (6%) in Study I and in four patients (4%) in Study II. The results of both studies have shown no clinically or statistically significant differences in toleration or efficacy between once daily and twice daily treatment regimens with 1% tioconazole cream for the treatment of superficial dermatophyte infections.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003881:Dermatomycoses / Q000188:drug therapy*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D011897:Random Allocation; D014005:Tinea / Q000188:drug therapy*
D000935:Antifungal Agents; D007093:Imidazoles; C020527:tioconazole