Clonal specificity of concanavalin A-induced cytotoxic T lymphocytes.
The specificity of polyclonally induced cytotoxic T lymphocyte (CTL) precursors has been analyzed under clonal conditions. Primary clones of concanavalin A-inducible CTL, if tested on different targets, revealed that they could distinguish between (a) two different allogeneic tumor targets; (b) allogeneic and syngeneic tumor targets, and (c) syngeneic B blasts and tumor targets. No "nonspecific" CTL clones were generated under these culture conditions, and all clones were found to display classical immunological specificity.
D000818:Animals; D002999:Clone Cells / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D003208:Concanavalin A