Are the renin-containing granules of juxtaglomerular epithelioid cells modified lysosomes?
Mature secretory granules of epithelioid cells--the so-called renin granules--exhibit certain properties, which in this particular combination are expressed only by lysosomes: Renin granules have autophagic capabilities; they react to the application of lipidosis-inducing, lysosomotropic substances by the gradual accumulation of polar lipids; all secretory granules of epithelioid cells contain acid phosphatase until maturity; and exogenous tracers reach renin granules without labeling the Golgi complex. Several functional implications can therefore be considered. Hydrolytic enzymes, constitutive elements of the granule matrix, might either cleave inactive prorenin to yield active renin within the granules or, by unspecific hydrolysis of renin, participate in the regulation of the overall quantity of secretory product. Autophagic phenomena, the involvement of renin granules in the traffic of exogenous tracers, and the build-up of polar lipids following experimental interference with lipid catabolism indicate a large turnover of membrane material in renin granules. They also suggest that cytoplasmic and extracellular fluid gains access to the granule content and may thus be involved there in the regulation of biochemical reactions by changing the intragranular milieu or via signal molecules. In addition to the lysosome-like properties of epithelioid cell secretory granules, the secretory product, renin, as a carboxyl protease, is structurally related to other acidic proteases. In the case of cathepsin D, even functional similarities exist.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001343:Autophagy; D002738:Chloroquine / Q000494:pharmacology; D002745:Chlorphentermine / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000648:ultrastructure; D007606:Juxtaglomerular Apparatus / Q000648:ultrastructure*; D008247:Lysosomes / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D012083:Renin / Q000378:metabolism*
D002738:Chloroquine; D000135:Acid Phosphatase; D012083:Renin; D002745:Chlorphentermine