[Immunosuppressive effect and promotor activity for hepatic carcinogenesis of thiobenzamide].
Thiobenzamide (TB) administration to rats (1 g/Kg of diet for 4 weeks) 10 days after a single i.p. injection of dimethylnitrosamine promotes the growth of preneoplastic liver lesions as evidenced by the sharp increase in number and area of gamma-glutamyltranspeptidase-positive hepatocellular foci. At the same time the number of the plaque forming cells isolated from the spleen of rats challenged with sheep red blood cell after the completion of a TB cycle is significantly lower than in the controls 5 as well 13 days after immunization. Accordingly, TB could act as immunodepressant in the rat; this should be taken into account as far as the promoting ability of such xenobiotic is concerned.
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine; D005260:Female; D006462:Hemolytic Plaque Technique; D007166:Immunosuppressive Agents; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013854:Thioamides / Q000494:pharmacology*
D000577:Amides; D002273:Carcinogens; D007166:Immunosuppressive Agents; D013854:Thioamides; D004052:Diethylnitrosamine; C015539:thiobenzamide
Effetto immunosoppressore ed attivita' promovente sulla cancerogenesi epatica da parte della tiobenzamide.