title: Prospective controlled evaluation of auditory function in neonates given netilmicin or amikacin.
abstract: Longitudinal assessment of intensive care nursery infants given aminoglycoside antibiotics revealed no significant difference in the incidence of hearing impairment when compared with age- and sex-matched controls. Bilateral sensorineural impairment was confirmed in three (2%) infants, one each given netilmicin and amikacin and one untreated control infant. There was a high incidence of transient auditory abnormalities in this intensive care infant population. These findings emphasize the importance of long-term follow-up hearing evaluations in infants who require intensive care management in the neonatal period.
mesh_terms: D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001300:Audiometry, Evoked Response; D001663:Bilirubin / Q000097:blood; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000009:adverse effects*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy*; D007612:Kanamycin / Q000031:analogs & derivatives*; D008137:Longitudinal Studies; D008297:Male; D009428:Netilmicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D005839:Gentamicins; D009428:Netilmicin; D007612:Kanamycin; D000583:Amikacin; D003404:Creatinine; D001663:Bilirubin