title: HLA in allergic twins.
abstract: Interest in the study and determination of the influence of a genetic factor in the etiology of bronchial asthma was initiated by Cook. This is a study of 13 pairs of twins that were seen in our department presenting some kind of allergic illness. Each pair of twins underwent a complete clinical history and physical examination, routine laboratory analysis and radiography. In addition, they were also tested for the following: skin test, serum immunoglobulins, total IgE, histamine release test, hemagglutination test, histocompatibility antigen (HLA). Statistical analysis was done using the Chi square test, with significant results found in 4 antigens, namely A2, A30 + 31, B5 and B12.
mesh_terms: D000293:Adolescent; D002648:Child; D004198:Disease Susceptibility; D004200:Diseases in Twins / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007158:Immunologic Techniques; D008297:Male; D011379:Prognosis
chemical_list: D006680:HLA Antigens