title: Factors influencing collagen-induced autoimmune ear disease.
abstract: In 1981, the authors described a type II collagen-induced autoimmune ear disease (CIAED) model. The purpose of this study was to gather further evidence that this is a sound animal model to use in evaluating inner ear diseases. The temporal bone lesions of CIAED in Lewis and Wistar rats were characterized by the presence of sensorineural hearing loss with mild atrophy of the organ of Corti and spiral ganglion degeneration, vestibular dysfunction with vacuolar degeneration of the crista ampullaris, otospongiosis-like lesions in the tympanic annules, cochlear vasculitis, and eustachian tube disease. Both cellular and humoral immune responses to type II collagen were demonstrated. The induction of ear lesions depends on many factors. In general, animals immunized with antigens in complete Freund's adjuvant showed relatively more severe lesions than animals immunized with antigens in incomplete Freund's adjuvant, but the duration of the immunization seems to be a more important factor in reproducing severe lesions. The strain and the source of the animals are also important factors in autoimmune inner ear diseases, as is the condition of the host animals. Subclinical or clinical mycoplasma infection in the rat markedly reduced the incidence and severity of lesions in type II collagen-induced arthritis. Many researchers did not consider sialoductal adenovirus, widely present among laboratory rats, a lesion-producing factor in rats. Although many factors influence the induction and severity of CIAED, these animal models provide an excellent new avenue of inner ear research.
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D003051:Cochlea / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000276:immunology*; D007758:Ear, Inner / Q000276:immunology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007116:Immunization, Passive; D007759:Labyrinth Diseases / Q000276:immunology; D051381:Rats; D014722:Vestibule, Labyrinth / Q000276:immunology
chemical_list: D001323:Autoantibodies; D003094:Collagen