Inhibition of cell proliferation by a synthetic C-nucleoside (EIT).
The effect of a C-nucleoside [4-(beta-D-erythrofuranosyl)-imidazoline-2-thione] on cell proliferation was studied. Two types of cell proliferation were used: Ehrlich ascites tumor cells obtained from NMRI mice, and the proliferative response of T lymphocytes from human peripheral blood to a mitogen (phytohemagglutinin). The uptake of 3H-thymidine was used as an index of cellular growth. The results indicate that this C-nucleoside had an inhibitory effect on both types of cell proliferation studied. Its possible application in tumor therapy and as an immunosuppressor in transplants is discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002455:Cell Division / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects; D013872:Thionucleosides / Q000494:pharmacology*
D008934:Mitogens; D010835:Phytohemagglutinins; D013872:Thionucleosides; C047000:4-(beta-erythrofuranosyl)imidazoline-2-thione