title: Bacterial colonization and neonatal infections. Effects of skin and umbilical disinfection in the nursery.
abstract: In a prospective randomized study different regimens for skin and umbilical disinfection in newborn infants were tested: daily whole body soap wash (control group), daily whole body soap wash and umbilical cleansing with (i) benzine solution, or (ii) 0.05% chlorhexidine, and daily whole body wash and umbilical cleansing with a 4% chlorhexidine detergent solution (Hibiscrub). Bacterial cultures were taken from the nose and umbilical area at discharge. Clinical infections were registered in the nursery, and after discharge until 6 weeks of age. Cultures were taken from infected areas. In the control group a high colonization rate was found for S. aureus (91%), E. coli (39%), and group B streptococci (GBS) (20%). The colonization rates were influenced by the Hibiscrub regimen (colonization rate for S. aureus 59%, E. coli 23%, and GBS 10%), but not by the other regimens. Infections (pemphigus, paronychia, conjunctivitis, umbilical infection) occurred in 12.9% of the infants, of whom 65% got infection after discharge from the nursery. 96% of the infections were caused by S. aureus, and 87% caused by strains colonizing the infants in the nursery. None of the tested regimens reduced the rate of infections during the first 6 weeks of life.
mesh_terms: D000473:Alkanes / Q000627:therapeutic use; D001424:Bacterial Infections / Q000517:prevention & control*; D002710:Chlorhexidine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003428:Cross Infection / Q000517:prevention & control*; D004202:Disinfectants / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D009666:Nose / Q000382:microbiology; D011446:Prospective Studies; D011897:Random Allocation; D012867:Skin / Q000382:microbiology*; D012915:Soaps; D014472:Umbilicus / Q000382:microbiology*
chemical_list: D000473:Alkanes; D004202:Disinfectants; D012915:Soaps; C004544:naphtha; D002710:Chlorhexidine