[Neonatal spasms caused by cerebral hemorrhage in alpha 1-anti-trypsin deficiency].
This paper describes a case of late neonatal convulsions due to intracranial haemorrhage in a newborn with cholestatic hepatopathy due to PiZZ homozygote alpha-1-antitrypsin deficiency. The deficiency of vitamin K dependent clotting factors, responsible for the haemorrhage, seems to be due to the cholestasis and might have been aggravated by the non-administration of vitamin K at birth and by breast feeding. The response to vitamin K therapy was good.
D002543:Cerebral Hemorrhage / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010641:Phenotype; D013036:Spasms, Infantile / Q000209:etiology*; D014812:Vitamin K / Q000008:administration & dosage; D019896:alpha 1-Antitrypsin Deficiency
D014812:Vitamin K
Neonatale Krämpfe infolge einer Hirnblutung bei Alpha-1-Antitrypsin-Mangel.