title: IgG-anti-IgG antibodies in juvenile chronic arthritis.
abstract: IgG antiglobulins were measured in 117 children with seronegative juvenile chronic arthritis (JCA). 100 had active disease, and these had significantly higher levels of IgG antiglobulins (mean 0.45 +/- 0.16 micrograms/ml) than the control group (mean 0.25 +/- 0.16 micrograms/ml (p less than 0.01]. The inactive group of patients had a mean of 0.14 +/- 0.06 micrograms/ml, comparable to a group of cord bloods from normal births (mean 0.14 +/- 0.05 micrograms/ml). In the active patients there was no difference when subdivision was made according to their mode of onset into pauciarticular, polyarticular, or systemic.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006046:Gold / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D010396:Penicillamine / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D006046:Gold; D010396:Penicillamine