Ontogenesis of gastrin cells in the pyloric antrum and duodenum of the mouse.
Ontogenesis of gastrin cells was studied in the pyloroduodenal mucosa of the mouse using anti-human G17 serum, R-1301, and anti-human G34(1-15) serum, R-2703. R-1301-immunostained cells first appeared in the pyloric mucosa of 14-day-old fetuses. Cells stained with both R-1301 and R-2703 appeared immediately after birth, and gradually increased in number to the adult level. Most R-1301-reactive cells were also reactive to R-2703, whereas some cells that reacted with R-1301 exhibited very weak or no reaction with R-2703. The discrepancy between these two immunoreactivities is discussed. In the duodenum, a considerable number of R-1301-reactive cells were present from the perinatal stage and through out adult development. A few R-2703-reactive cells were seen in the duodenum of young mice but not of the adult.
D000367:Age Factors; D000818:Animals; D004386:Duodenum / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D007158:Immunologic Techniques; D051379:Mice; D008813:Mice, Inbred ICR / Q000254:growth & development*; D013270:Stomach / Q000166:cytology* / Q000254:growth & development
D005755:Gastrins