title: [Antitumor activity of ribonucleases].
abstract: The data on antitumour activity of pancreatic. RNase are reviewed. Problems associated with the antitumour activity of RNase As(BS) and synthetic dimers of RNase A, microbic RNase are considered and analyzed. The data on the significance of engineering-enzymological approaches for increasing the antitumour RNase activity are discussed.
mesh_terms: D000190:Actinomyces / Q000201:enzymology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001407:Bacillus / Q000201:enzymology; D002286:Carcinoma, Ehrlich Tumor / Q000628:therapy*; D066298:In Vitro Techniques; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D051379:Mice; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000627:therapeutic use; D012260:Ribonucleases / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000628:therapy*; D012706:Serratia marcescens / Q000201:enzymology
chemical_list: D000970:Antineoplastic Agents; D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic
vernacular_title: Protivoopukholevaia aktivnost' ribonukleaz.