[Cytolytic activity of macrophages from 5 strains of rats].
Resident peritoneal macrophages from 5 conventional or pathogen-free rat strains, without in vivo or in vitro stimulation, were generally tumoricidal in vitro against tumor cells: this spontaneous cytolysis rate varied from one rat to another but was significantly different according to the strains. Endotoxins induced or increased macrophage-mediated cytolysis from BDIX, Wistar and Sprague-Dawley rats; they were without effect on those from Long-Evans rats and their effect was irregular on Sprague-Dawley Hairless macrophages. Endotoxin effect depended on natural cytolysis intensity.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D004731:Endotoxins / Q000494:pharmacology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology*
D004731:Endotoxins
Etude de l'activité cytolytique de macrophages provenant de cinq souches de rats.