Experimental elimination of various intestinal segments by means of devascularization (devitalization).
Segments of the small and large intestine, of varying lengths (10-180 cm), were devascularized by simultaneously ligating the mesenteric arteries and veins. When the circulation had been cut off, the ends of the devascularized segment were both ligated, continuity of intestinal passage was renewed by forming an anastomosis and the isolated segment was left in situ, together with its contents. Contrary to accepted views, no changes leading to death (necrosis and peritonitis) occurred, but the devascularized tissue was progressively destroyed and reconstructed until, after four weeks, all that was left was a minute fibrous residue. None of 41 pigs died as a result of devascularization, including those in which large doses of pathogenic microorganisms were injected into the isolated segment. The possibility of employing this technique in the surgical treatment of inoperable tumours is discussed.
D000818:Animals; D001329:Autolysis; D007413:Intestinal Mucosa / Q000473:pathology; D007420:Intestine, Large / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D007421:Intestine, Small / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D008026:Ligation; D008638:Mesenteric Arteries / Q000601:surgery; D008642:Mesenteric Veins / Q000601:surgery; D009336:Necrosis; D013536:Suture Techniques; D013552:Swine; D013556:Swine, Miniature