Immunotoxicological investigation of the effects of a pesticide; cypermethrin.
The effects of a synthetic pyrethroid pesticide cypermethrin on the immune system were studied. The effect of a daily oral administration of 1/40, 1/20 and 1/10 of LD50 was studied in rabbits for its influence on the humoral immune response after vaccination with Salmonella typhi, as well as on cell-mediated immunity. The two higher doses induced a significant dose-dependent decrease of serum antibody titers. The skin redness measured in the tuberculin skin test showed the same dose-dependent tendency. In subacute experiments with rats, a significant dose-dependent decrease was observed both in the anti-ovalbumin titer of blood sera measured in passive hemagglutination test and in the autologous rosette-formation of T-lymphocytes in groups fed the higher doses.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001428:Bacterial Vaccines / Q000276:immunology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007107:Immune System / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D011722:Pyrethrins / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012397:Rosette Formation; D012485:Salmonella typhi / Q000276:immunology; D014374:Tuberculin Test
D001428:Bacterial Vaccines; D011722:Pyrethrins; C017160:cypermethrin