[Characterization of immune complexes in normal pregnancies].
There are many reports on the immune complexes in normal pregnancies. Nevertheless, even the presence of immune complexes in normal pregnancies have not been clarified, and the immune complexes have not been clearly characterized. So, in this report, I try to make clear whether immune complexes are present in normal pregnancies or not, and then to analyze the immune complexes in normal pregnancies. The results are as follows: The immune complex (IC) levels measured by the C1q binding test rose in first trimester, and dropped to the normal range in the second and third trimesters. The IgG-IC levels increased in the first trimester and decreased to the normal range in the second and third trimesters, but the IgM-IC levels were not changed during normal pregnancies in the solid phase anti C3 radioimmunoassay. The ICs in normal pregnancies were analyzed using gel filtration. IgG-ICs were detected in the first trimester and the third trimester of normal pregnancies, and the molecular weights were about 290,000. IgG-ICs were separated from another immunoglobulin class IC using a DEAE-affigel blue column. ICs in normal pregnancies were mainly IgG-IC and there were only a few IgM-ICs in normal pregnancies. IgG-ICs were present in normal pregnancies, but neither the classical pathway nor the alternative pathway of the complement system was found to be activated by the two-dimensional electroimmunodiffusion method using anti C3 and C1s. So, IgG-IC in normal pregnancies did not seem to be pathological.
D000936:Antigen-Antibody Complex; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D011247:Pregnancy; D011863:Radioimmunoassay
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D015922:Complement C1q; D003166:Complement Activating Enzymes