Antibacterial activity of cefminox against anaerobes.
The antibacterial activity of cefminox (CMNX) against anaerobic bacteria was studied in vitro. The results are as follows: 1. CMNX exerted antibacterial activity against a wide range of anaerobes, excluding Clostridium innocuum. The antibacterial activity of CMNX against Bacteroides fragilis was comparable to that of latamoxef and superior to cefoxitin, but CMNX's activity against anaerobic cocci was slightly inferior to cefoxitin's; 2. A comparison of the MICs and MBCs of CMNX indicated that this drug exerts a complete bactericidal effect at a concentration which inhibits the growth of bacteria; 3. CMNX was found to be stable to the beta-lactamases produced by B. fragilis; 4. CMNX exerted an antibacterial activity against C. difficile.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001441:Bacteroides fragilis / Q000201:enzymology; D002513:Cephamycins / Q000494:pharmacology*; D004355:Drug Stability; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002513:Cephamycins; D001618:beta-Lactamases; C046079:cefminox