Effect of high dose corticosteroids alone or combined with other drugs on survival in septic shock.
The effect of high dose corticosteroids on survival has been studied in a limited number of canine septic shock models which are reviewed in this presentation. Following injection of live bacteria neither methylprednisolone, nor gentamicin but a combination improved survival. Methylprednisolone increased survival following a slow but not a bolus infusion of endotoxin. In a recent study the effects of short term treatment with methylprednisolone, naloxone and ibuprofen were studied in endotoxin shock. All control animals died within 36 hours. Five of 9 dogs receiving the combination methylprednisolone, naloxone and ibuprofen were permanent survivors. The combined treatment with methylprednisolone and ibuprofen also increased survival. Dogs treated with methylprednisolone alone did not differ significantly from controls. It is concluded that methylprednisolone alone has no significant effect on survival in septic shock, but seems to be an important therapeutic factor to achieve increased survival.
D000818:Animals; D004285:Dogs; D004359:Drug Therapy, Combination; D004731:Endotoxins / Q000008:administration & dosage; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009270:Naloxone / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy*
D004731:Endotoxins; D009270:Naloxone; D007052:Ibuprofen; D008775:Methylprednisolone