Lack of growth hormone-dependent somatomedins or growth retardation in hypophysectomized fetal lambs.
Fetal lambs were hypophysectomized and, after 8 days of recovery, given infusions of GH, prolactin, thyroxine and insulin with glucose. Hypophysectomy caused no consistent reduction in fetal plasma somatomedin-like activity. Fetal infusions of GH or prolactin caused no consistent change in plasma somatomedin-like activity. It was concluded that fetal somatomedin-like activity is not GH dependent. After hypophysectomy fetal lambs showed no reduction in body weight or length at term.
D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D005947:Glucose / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology; D007016:Hypophysectomy; D007328:Insulin / Q000494:pharmacology; D010902:Pituitary Gland / Q000502:physiology*; D011388:Prolactin / Q000494:pharmacology; D012756:Sheep; D013002:Somatomedins / Q000097:blood*; D013974:Thyroxine / Q000494:pharmacology
D007328:Insulin; D013002:Somatomedins; D011388:Prolactin; D013006:Growth Hormone; D005947:Glucose; D013974:Thyroxine