Interaction of UAG suppressors and omnipotent suppressors in Saccharomyces cerevisiae.
Haploids bearing the dominant UAG suppressor, SUP7-a, and various alleles of the omnipotent suppressor sup35 were examined. The presence of the UAG suppressor reduced the efficiency of some alleles of sup35, and caused other sup35 alleles to be lethal. A nonclassical interaction of the dominant suppressor tRNA and the ribosome is proposed to explain these observations.
D003062:Codon; D009154:Mutation; D012333:RNA, Messenger; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013489:Suppression, Genetic
D003062:Codon; D012333:RNA, Messenger