title: Hypotensive effect in the rat after oral prostacyclin (PGI2).
abstract: PGI2 dose dependently lowers mean systemic arterial pressure in conscious normotensive and spontaneously hypertensive rats after oral administration. The ED30 was respectively 0.79 and 0.63 mg/kg. Heart rate was not significantly modified. The hypotensive effect appears to be due to PGI2 itself and not to its metabolite 6-keto-PGF1 alpha which, administered at 2 mg/kg p.o., did not modify blood pressure.
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D011464:Epoprostenol / Q000494:pharmacology*; D008297:Male; D051379:Mice
chemical_list: D000959:Antihypertensive Agents; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol