Antimicrobial susceptibility of Pneumocystis carinii in culture.
Pneumocystis carinii from infected rats were cultured on infected WI-38 human lung fibroblasts. After cultures were established, medium was replaced by medium containing antimicrobials and supernate organisms counted at specified times. Results show that metronidazole had no effect, amphotericin B suppressed organisms at 5 but not 0.5 microgram/ml, and miconazole, chloroquine, trimethoprim-sulfamethoxazole, and pentamidine isethionate suppressed organisms at the concentrations tested.
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002460:Cell Line; D002738:Chloroquine / Q000494:pharmacology*; D003470:Culture Media; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D010419:Pentamidine / Q000494:pharmacology; D011010:Pneumocystis / Q000187:drug effects* / Q000254:growth & development; D051381:Rats; D011919:Rats, Inbred Strains; D013420:Sulfamethoxazole / Q000494:pharmacology; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D003470:Culture Media; D004338:Drug Combinations; D008795:Metronidazole; D010419:Pentamidine; D008825:Miconazole; D000666:Amphotericin B; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D002738:Chloroquine; D014295:Trimethoprim; D013420:Sulfamethoxazole