Differential neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Swiss-Webster mice from different sources.
Male Swiss-Webster mice obtained from three different commercial suppliers were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Mice from one of the three suppliers were considerably more sensitive to the neurotoxic effects of MPTP than mice from the others. For example the MPTP-induced decrements in the neostriatal levels of dopamine and its metabolites, which are a reflection of the neurotoxic process, were considerably greater in the sensitive strain than in the less sensitive strains.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced*; D011725:Pyridines / Q000633:toxicity*; D013045:Species Specificity
D011725:Pyridines; D015102:3,4-Dihydroxyphenylacetic Acid; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D006719:Homovanillic Acid