title: Rectal methohexitone induction in pediatric outpatients: physostigmine does not enhance recovery.
abstract: Rectal methohexitone (25 mg X kg-1) was used to induce anaesthesia in 15 unpremedicated children scheduled to undergo bilateral myringotomies as outpatients. Induction time ranged from 4 to 11 minutes. In the recovery room, all children received a slow intravenous injection of physostigmine (60 micrograms X kg-1), or saline in a double blind randomized fashion. The use of physostigmine did not significantly decrease the recovery room stay as compared to placebo (34 vs. 43 minutes). Vomiting and soiling were two side-effects associated with the use of physostigmine.
mesh_terms: D000367:Age Factors; D000758:Anesthesia; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D008723:Methohexital / Q000008:administration & dosage*; D010830:Physostigmine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011446:Prospective Studies; D011897:Random Allocation; D012007:Rectum; D014432:Tympanic Membrane / Q000601:surgery
chemical_list: D010830:Physostigmine; D008723:Methohexital