Further evidence for a cell surface proteinase essential to the growth of cultured fibroblasts.
Specific antibodies and protein proteinase inhibitors will inhibit cell-surface proteinase activity on human fibroblasts and cause a concomitant inhibition of DNA synthesis and of cell multiplication. An insolubilized proteinase inhibitor also inhibits cell multiplication. The same reagents partially inhibit the multiplication of mouse L cells, both in monolayer and suspension culture, and inhibit the mitogenic effect of epidermal growth factor (EGF) on both types of cell.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002455:Cell Division; D002462:Cell Membrane / Q000201:enzymology*; D002478:Cells, Cultured / Q000166:cytology* / Q000201:enzymology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006801:Humans; D007739:L Cells; D008168:Lung; D051379:Mice; D010447:Peptide Hydrolases / Q000276:immunology / Q000502:physiology*; D011480:Protease Inhibitors
D011480:Protease Inhibitors; D004815:Epidermal Growth Factor; D010447:Peptide Hydrolases