Prevention and treatment of venous ulceration.
Venous ulcers are related to incompetence of the direct calf and ankle perforating veins, the majority of which follow deep vein thrombosis. Prevention of the latter by intravenous micro-dose heparin (1 unit/kg/hour) is effective, safe and inexpensive. Its efficacy has been proved in two controlled clinical trials. Venous ulcers have been treated by perforating vein ligation, with saphenous ligation and stripping where necessary, and with the addition of permanent knee-length elastic compression stockings in patients with femoro-popliteal incompetence. This regimen has achieved a 92% long-term success rate in patients without rheumatoid arthritis.
D002986:Clinical Trials as Topic; D003020:Clothing; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008026:Ligation; D008297:Male; D008875:Middle Aged; D013924:Thrombophlebitis / Q000150:complications; D014647:Varicose Ulcer / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D014689:Venous Insufficiency / Q000150:complications
D006493:Heparin