Interaction of epidermal growth factor with initiators and complete carcinogens in the C3H10T1/2 cell culture system.
Unlike 12-O-tetradecanoylphorbol-13-acetate, epidermal growth factor (EGF) could not promote the appearance of type III foci from initiated C3H10T1/2 cells. At appropriate concentrations, EGF induced the formation of type II colonies in the absence of any initiator. At higher concentrations, EGF suppressed the induction of both type II and type III colonies elicited by methylcholanthrene.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D003043:Cocarcinogenesis; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects*; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014410:Tumor Stem Cell Assay
D002273:Carcinogens; D008748:Methylcholanthrene; D004815:Epidermal Growth Factor; D013755:Tetradecanoylphorbol Acetate