Monoclonal antibodies reveal sagittal banding in the rodent cerebellar cortex.
We have produced two monoclonal antibodies against polypeptide-associated antigens of developing rat cerebellum. One antibody recognizes an antigen associated with synaptic vesicles and another binds to a polypeptide which is restricted to the cytoplasm of a subset of cerebellar Purkinje cells. Both antibodies reveal the biochemical differentiation of the rodent cerebellar cortex into antigenically distinct sagittal zones.
D000818:Animals; D000911:Antibodies, Monoclonal; D002525:Cerebellar Cortex / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008854:Microscopy, Electron; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011689:Purkinje Cells / Q000276:immunology; D051381:Rats; D013570:Synaptic Membranes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins