title: [Sensitivity of the splenic immunocompetent cells of mice with different genotypes to the action of alkylating agents].
abstract: It has been established in experiments in vitro that splenocytes of DBA/2GSto mice are more sensitive to the immunosuppressant action of the alkylating agents (cyclophosphamide, sarcolysine and thiophosphamide) than splenocytes of BALB/cGLacSto mice. Splenocytes of C3H/SnRap mice exhibit and intermediate type of sensitivity. T-lymphocytes of the spleen of BALB/cGLacSto and DBA/2GSto mice are more sensitive in vitro to the action of active metabolites of cyclophosphamide as compared to B-lymphocytes, with both types of the cells of DBA/2GSto mice being affected to a greater extent than the cells of BALB/cGLacSto mice.
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D005838:Genotype; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
chemical_list: D000477:Alkylating Agents; D007166:Immunosuppressive Agents
vernacular_title: Chuvstvitel'nost' immunokompetentnykh kletok selezenki mysheĭ raznykh genotipov k deĭstviiu alkiliruiushchikh agentov.