title: Spontaneous lymphomas in mice genetically selected for high or low phytohemagglutinin responsiveness.
abstract: Biozzi mice selected for high (Hi) or low (Lo) responsiveness to phytohemagglutinin (PHA) have been followed for their entire life-span to examine their pathology at death. Spontaneous lymphomas were found to exhibit higher incidence and faster development in Lo/PHA than in Hi/PHA females, whereas a similar difference between the two lines did not attain the level of statistical significance in male mice. The incidence of solid tumors was higher in Lo/PHA than in Hi/PHA males but the same in females of the two lines, yet the probability of dying from solid tumors was slightly increased in Lo/PHA mice of both sexes. All these results indicate that T-cell-mediated immunity influences mainly the spontaneous incidence of lymphomas and, to a lesser degree, the appearance of other solid tumors.
mesh_terms: D000818:Animals; D001996:Bronchopneumonia / Q000453:epidemiology / Q000662:veterinary; D005260:Female; D008136:Longevity; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000662:veterinary*; D008297:Male; D051379:Mice / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012376:Rodent Diseases / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D010835:Phytohemagglutinins