Neoplastic cell transformation by heavy charged particles.
With confluent cultures of the C3H10T1/2 mammalian cell line, we have investigated the effects of heavy-ion radiation on neoplastic cell transformation. Our quantitative data obtained with high-energy carbon, neon, silicon, argon, iron, and uranium particles show that RBE is both dose- and LET-dependent for malignant cell transformation. RBE is higher at lower doses. There is an increase of RBE with LET, up to about 100-200 keV/micron, and a decrease of RBE with beams of higher LET values. Transformation lesions induced by heavy particles with LET values greater than 100 keV/micron may not be repairable in nonproliferating cells. RBE for slow and nonproliferating cells may be much higher than for actively growing cells.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004601:Elementary Particles; D004735:Energy Transfer; D007477:Ions; D051379:Mice; D008809:Mice, Inbred C3H; D012062:Relative Biological Effectiveness
D007477:Ions