Serum ferritin as a prognostic indicator in neuroblastoma: biological effects of isoferritins.
These studies suggest that a) the levels of serum ferritin are closely related to the prognosis of patients with neuroblastoma; b) the increased amounts of ferritin in the serum of patients with neuroblastoma are, in part, derived from the tumor; c) isoferritins from neuroblastoma cells exert adverse effects on the host immune response and host defenses; and d) therefore, isoferritins released from tumors may, in part, be responsible for the poor prognosis of patients with elevated levels of serum ferritin.
D000818:Animals; D002648:Child; D005293:Ferritins / Q000097:blood* / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007501:Iron / Q000097:blood; D008213:Lymphocyte Activation; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009447:Neuroblastoma / Q000097:blood*; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D005293:Ferritins; D007501:Iron