[Antitumor effect of JM-8 (a cisplatin analogue) on testicular cancer cells in vitro and in vivo].
Using transplantable testicular tumor lines serially passaged in nude mice, the antitumor effect of JM-8, an analogue compound of cisplatin, was evaluated by clonogenic assay and in nude mice. JM-8 exhibited compatible tumor growth inhibition to that of 8 to 10 times the concentration of cisplatin both in vitro and in vivo. In addition, JM-8 had less toxicity than cisplatin in vivo. However, when JM-8 was adopted for treatment of regrowing tumors after repeated manipulations with cisplatin, it exerted less growth inhibition than cisplatin. Apart from this effect, it was considered that JM-8 could be substituted for cisplatin in clinical use.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D016190:Carboplatin; D002945:Cisplatin / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D016190:Carboplatin; D002945:Cisplatin