Iron(III)-nitrilotriacetate: an agent for reducing the time interval of tumor imaging with gallium citrate.
Increasing interest in the short-lived radionuclide 68Ga (t1/2: 68.2 min) has revived basic studies of gallium radiopharmaceuticals. Ga-citrate (Ga-cit), described as a polynuclear complex, possesses great affinity for tumor cells but is also bound by blood transferrin (Tf). Exploitation of reaction-rate differences in metal ion transference from Ga-cit to Tf (slow) and Fe-nitrilotriacetate (Fe-NTA) to Tf (fast) is put to use to attain a proper tumor/tissue ratio within practical time limits. Studies on administration mode, time and dose offered promising results for future 68Ga-cit tomographic studies.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging*; D005290:Ferric Compounds; D005710:Gallium Radioisotopes; D007501:Iron; D007668:Kidney / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009132:Muscles / Q000000981:diagnostic imaging; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives*; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D005290:Ferric Compounds; D005710:Gallium Radioisotopes; D007501:Iron; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate