Pesticide-drug interaction in rats.
The possible interactions between a fungicide, thiram, and some drugs acting on the central nervous system were investigated in rats by means of behavioral methods. Potentiation was found after combined treatment with thiram and promethazine, and after thiram and meprobamate. In the case of trihexyphenidyl, an additive interaction was observed. It is presumed that these observations will be of practical toxicological significance.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D004357:Drug Synergism; D005260:Female; D006120:Grooming / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D008620:Meprobamate / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D009949:Orientation / Q000187:drug effects*; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013037:Spatial Behavior / Q000187:drug effects*; D013859:Thiocarbamates / Q000494:pharmacology*; D013893:Thiram / Q000494:pharmacology*; D014282:Trihexyphenidyl / Q000494:pharmacology*
D013859:Thiocarbamates; D013893:Thiram; D014282:Trihexyphenidyl; D008620:Meprobamate; D006899:Mixed Function Oxygenases; D004299:Dopamine beta-Hydroxylase; D011398:Promethazine