Concepts in coeliac disease: is there a receptor for gliadin?
Genetic, biochemical and immunological theories have added to our knowledge of coeliac pathogenesis. There are new data, however sparse, to support a unifying pathogenetic concept, namely the hypothesis of a glycoprotein specific cellular receptor for gliadin on lymphocytes and enterocytes.
D001402:B-Lymphocytes / Q000276:immunology; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002648:Child; D004848:Epithelium / Q000378:metabolism; D005903:Gliadin / Q000276:immunology / Q000378:metabolism*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic / Q000378:metabolism*
D006680:HLA Antigens; D007136:Immunoglobulins; D010940:Plant Proteins; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; C032193:glycoprotein receptor GPIb-IX; D005903:Gliadin