title: Asbestos-related disease in railroad workers. A cross-sectional study.
abstract: A cross-sectional prevalence study of 377 railroad workers was carried out. The purpose was to investigate the prevalence of asbestos-related disease. We compared conventional with more recently adopted criteria for defining abnormal lung function. We compared the test results of those who performed reproducibly on spirometry with those who did not. Medical and occupational histories, flow-volume loops, and posteroanterior and lateral chest radiographs were obtained. Single-breath carbon monoxide diffusing capacity (DLCO) was measured, and chest auscultation was performed. Related to time since onset of exposure, pleural plaques occurred in 22.9%. There was radiographic evidence of interstitial disease in 1.6%. Reduced single-breath DLCO (12.4%), crackles (18.4%), and dyspnea (49.6%) were significantly associated with asbestos exposure. The prevalence of restriction and obstruction was 5.1 and 12.4%, respectively, but differed (p = 0.0001) with the definition criteria selected. The proportion with each of these abnormalities was higher in the nonreproducible group. That group was older, with more pleural plaques and chronic bronchitis. Railroad workers are a group at risk for asbestos-related disease. Extent of disease and assumptions about causality are likely to vary with definitions of normalcy and the use of reproducibility criteria.
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D010414:Pennsylvania; D011859:Radiography; D011890:Railroads; D012306:Risk; D012907:Smoking; D014797:Vital Capacity
chemical_list: D001194:Asbestos