[Behavior of selected oxidoreductases in histochemical and electro- phoretic studies of the rat kidney after administration of Biseptol 480 (co-trimoxazole)].
Examinations of the rat kidney metabolism were carried out by histological (staining with haematoxylin and eosin), histochemical (response to lactate and succinic dehydrogenases activities), and electrophoretic methods (separation of isoenzymes of lactate dehydrogenase) after treating animals with the sulphonamide Biseptol 480, for 7 (consecutive) d by stomach tube. Biseptol given to the animals exceeded 10 times human therapeutical dose. It was found out that Biseptol 480, applied to the animals with healthy urinary system, does not pathologically disturb the examined stages of the metabolic processes in the rat's kidney.
D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D007527:Isoenzymes; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000302:isolation & purification / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013420:Sulfamethoxazole / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D007527:Isoenzymes; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D013420:Sulfamethoxazole
Beobachtungen des Verhaltens ausgewählter Oxidoreductasen in histochemischen und elektrophoretischen Untersuchungen der Rattenniere nach Verabreichung von Biseptol 480 (Co-Trimoxazole).