title: Lactate vulnerability of remitted panic patients.
abstract: Sodium lactate precipitates panic in 70-100% of clinically ill patients with panic disorders. The lactate vulnerability of remitted patients is unknown. In this study, 13 panic patients completed three sequential sodium lactate infusions: one before treatment, a second when panic free on tricyclic antidepressants (TCA), and a third when in remission and unmedicated for 1 to 6 months. Three out of 13 patients panicked at the third infusion as compared to 0/13 infused on TCA and 7/12 at pretreatment infusion. This result (1) indicates that lactate vulnerability can exist in clinically well, unmedicated patients, and (2) raises the possibility that lactate vulnerability may be a trait characteristic. Further studies are needed before definite conclusions can be drawn.
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000175:diagnosis; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005239:Fear / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D019832:N-Methylscopolamine; D010200:Panic / Q000187:drug effects*; D010698:Phobic Disorders / Q000175:diagnosis / Q000188:drug therapy; D012602:Scopolamine Derivatives / Q000627:therapeutic use
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007773:Lactates; D012602:Scopolamine Derivatives; D019344:Lactic Acid; D007099:Imipramine; D019832:N-Methylscopolamine