title: [Cytotoxic activity of the serum of schizophrenic patients].
abstract: The action of blood serum obtained from 38 schizophrenic patients and 28 control subjects was studied on new cells: Chinese hamster kidney, diploid human cells and glial cultures of immature ependymoblastoma of type 5 mice (IE-5) and neurinoma of rat trigeminal ganglion. Sera of schizophrenic patients--especially of those with a continuous course and disease standing over 5 years and with a recurrent course and disease standing less than 5 years--were found to be significantly more toxic. In the culture of IU-5, sera from schizophrenic patients of a younger age (the mean age 27 years) exerted the most pronounced cytolytic action. Toxic activity of the serum of schizophrenic patients persisted for 14 days at +4 degrees C and 60 days at -30 degrees C but was reduced following thermal treatment (+56 degrees C, 30 min).
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004806:Ependymoma; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D007668:Kidney; D051379:Mice; D008875:Middle Aged; D009442:Neurilemmoma; D012559:Schizophrenia / Q000097:blood*; D014118:Toxins, Biological / Q000097:blood; D012668:Trigeminal Ganglion
chemical_list: D007106:Immune Sera; D014118:Toxins, Biological
vernacular_title: Tsitotoksicheskaia aktivnost' syvorotki krovi bol'nykh shizofrenieĭ.