title: The development and ultrastructure of Plasmodium falciparum damaged in vitro by human "crisis" sera and by chloroquine.
abstract: P. falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after chloroquine administration. Intra-erythrocytic parasite damage was seen by light and electron microscopy. The significance of the results is discussed with relevance to non-specific immune mechanisms, and the damage induced by these mechanisms compared with that from chloroquine.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D004660:Encephalitis / Q000276:immunology; D004912:Erythrocytes / Q000469:parasitology / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D008288:Malaria / Q000097:blood / Q000276:immunology / Q000469:parasitology*; D008581:Meningitis / Q000276:immunology; D008854:Microscopy, Electron; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure
chemical_list: D002738:Chloroquine