[Stimulation of restorative processes in stomach and duodenal ulcers].
The effects of RNA preparations and symptomatic agents (antacids and cholinolytics) were studied and compared in patients with peptic ulcer of the stomach and duodenum. It was shown that the use of RNA preparations led to a more rapid disappearance of the endoscopic, x-ray and morphological signs of ulceration, epigastric symptoms, nausea and vomiting, anorexia, "latent" blood in the feces. Altogether 92% of the patients responded to RNA preparations, and 72% to the symptomatic treatment. The rate of relapses it the patients on RNA was 8%, that in the patients on the symptomatic agents amounted to 20%. The mechanism of action of RNA preparations in patients with peptic ulcer of the stomach and duodenum lies in stimulation of protein biosynthesis in the mucous membrane of the involved stomach and intestine, which leads to intensification of the reparative processes.
D000293:Adolescent; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009696:Nucleic Acids / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D009696:Nucleic Acids; D001285:Atropine; C013683:sodium nucleinate; C010804:bismuth subnitrate; D001729:Bismuth
Stimuliatsiia vosstanovitel'nykh protsessov pri iazvennoĭ bolezni zheludka i dvenadtsatiperstnoĭ kishki.