Interleukin-1 from P388D1: effects upon neutrophils, plasma iron, and fibrinogen in rats, mice, and rabbits.
Partially purified interleukin-1 was prepared from the murine cell line P388D1. This interleukin-1 produced fever in rabbits and the amount required to cause an increase of 1 degree C was determined. This dose of interleukin-1 produced neutrophilia when injected into rats and rabbits but not in mice, and increased plasma iron and fibrinogen in all three species. Although the mouse was a poor responder to murine interleukin-1 for neutrophilia, it responded unusually well for increasing plasma fibrinogen.
D000818:Animals; D005340:Fibrinogen / Q000032:analysis*; D007375:Interleukin-1; D007501:Iron / Q000097:blood*; D007941:Leukemia P388 / Q000097:blood*; D007942:Leukemia, Experimental / Q000097:blood*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D007375:Interleukin-1; D005340:Fibrinogen; D007501:Iron