Immunoglobulins in healthy controls: HLA-B8 and sex differences.
Serum immunoglobulins were measured in one hundred and eighty-four healthy controls. One hundred and fifty-nine of these were also HLA typed. IgG levels did not differ with sex or HLA-B8 status. IgM levels did not differ with HLA-B8 status but were significantly higher in females than males. IgA levels were lower in females than males; they were also lower in HLA-B8 positive compared with HLA-B8 negative individuals; the lowest IgA levels were found in HLA-B8 positive females. The IgA variation may be relevant to the higher incidence of certain disorders among HLA-B8 positive individuals and among females.
D000328:Adult; D002446:Celiac Disease / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D015795:HLA-B8 Antigen; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D008297:Male; D012737:Sex Factors
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins