[Use of autoradiography. Studies of cell kinetics in normal and psoriatic epidermis as an aid in decision making in therapeutic management].
We report on cell kinetic data about in vivo and in vitro DNA-labelling of germinative keratinocytes in normal and psoriatic epidermis. In order to study the cell cycle and its component parts in psoriasis, information on duration of the DNA-synthesis phase, epidermal germinative growth fraction, as well as cell cycle time are of special interest. Comparison of various anti-psoriatics reveals that they have different effects on the cell cycle in psoriatic epidermis. This observation may be important for the development and analysis of new treatment schedules and their influence on psoriatic cell proliferation kinetics.
D000875:Anthralin / Q000494:pharmacology / Q000627:therapeutic use; D001345:Autoradiography; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D013638:Tars / Q000494:pharmacology / Q000627:therapeutic use; D014466:Ultraviolet Rays
D013638:Tars; D004247:DNA; D000875:Anthralin
Uber den Einsatz der Autoradiographie. Zellkinetische Untersuchungen an normaler und psoriatischer Epidermis als Entscheidungshilfe für therapeutische Massnahmen.