title: Effects of prostaglandin F2 alpha and indomethacin on the contractile activity of different compartments of the complex stomach.
abstract: In vitro experiments have shown that PGF2 alpha or indomethacin produces different effects on muscle strips isolated from different compartments of sheep complex stomach. PGF2 alpha (10(-6) - 10(-5) M) increases the tone of the ruminal preparations and exerts a negligible effect on the reticulum and omasum strips. Indomethacin (5 X 10(-6) M) inhibits the mechanical activity of the rumen and omasum and has no effect on that of the reticulum. More pronounced are the effects on the different parts of the abomasum: PGF2 alpha (10(-9) - 10(-6) M) markedly increases the tone of the proximal abomasum and decreased the amplitude and the phasic contractions of the antral abomasum; indomethacin (5 X 10(-6) M) inhibits the tone and the phasic contractions of the middle abomasum. PGF2 alpha (10(-9) - 10(-6) M) inhibits while indomethacin (5 X 10(-6) M) stimulates the contractile activity of the antral abomasum.
mesh_terms: D000018:Abomasum / Q000187:drug effects; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost; D005711:Gallopamil / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009851:Omasum / Q000187:drug effects; D011460:Prostaglandins F / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012159:Reticulum / Q000187:drug effects; D012417:Rumen / Q000187:drug effects; D012756:Sheep
chemical_list: D011460:Prostaglandins F; D005711:Gallopamil; D015237:Dinoprost; D000109:Acetylcholine; D007213:Indomethacin