Age-dependent effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).
The neurotoxic effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) have been shown to be dependent upon its conversion to 1-methyl-4-phenyl pyridine ion (MPP+) by monoamine oxidase. Since central monoamine oxidase activity increases with age, the neurotoxic effects of MPTP should be age-dependent. This hypothesis was evaluated by administering MPTP to three groups of rats differing in age. It was observed that both the lethality and neurotoxicity of MPTP were age-dependent.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D011725:Pyridines / Q000633:toxicity*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D011725:Pyridines; D012701:Serotonin; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine