Blood and brain n-pentanol in inhalation exposure.
Male Wistar rats exposed to 100, 300 or 600 p.p.m. n-pentanol vapour for 7 to 14 weeks during five days weekly and 6 hrs daily showed a dose-dependent blood n-pentanol concentration. The brain n-pentanol content was linearly related to the blood pentanol concentrations although this relationship changed after 14 weeks because the brain n-pentanol was significantly smaller than the respective values at 7 weeks. Valeraldehyde, the primary metabolite of n-pentanol, was only found in the brain at the highest vapour dose level. The liver n-pentanol dehydrogenase and 7-ethoxycoumarin O-deethylase activities remained unchanged while kidney ethoxycoumarin deethylase activity was enhanced in a dose-dependent manner at both time points. Brain and muscle acetylcholinesterase activities were increased by the exposure dose-dependently after 7 weeks although this effect ameliorated after 14 weeks. Moderate n-pentanol vapour exposure seems to cause metabolic and functional adaptation in its target organs.
D000110:Acetylcholinesterase / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000447:Aldehydes / Q000097:blood / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005740:Gases; D007668:Kidney / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009132:Muscles / Q000201:enzymology; D000439:Pentanols / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D005740:Gases; D000439:Pentanols; D003577:Cytochrome P-450 Enzyme System; C046012:pentanal; D006899:Mixed Function Oxygenases; D000429:Alcohol Oxidoreductases; D000110:Acetylcholinesterase; C024999:n-pentanol