Amphotericin clearance in vitrectomized versus nonvitrectomized eyes.
Ocular clearance of amphotericin B after direct intravitreal injection was studied in a rabbit model. Unmodified phakic eyes, Candida-infected eyes, aphakic eyes, and aphakic vitrectomized eyes were employed. Using high pressure liquid chromatography to assess drug level, the half-lives of drug disappearance after single 10-microgram (microgram) intravitreal injections were 9.1, 8.6, 4.7, and 1.4 days, respectively. The disappearance slope for vitrectomized eyes was significantly different from all nonvitrectomized eyes with P less than 0.001. The rapid disappearance of amphotericin from vitrectomized eyes must be considered in clinical management of patients with fungal endophthalmitis.
D000666:Amphotericin B / Q000378:metabolism*; D000818:Animals; D002177:Candidiasis; D009877:Endophthalmitis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006207:Half-Life; D007700:Kinetics; D011817:Rabbits; D012016:Reference Values; D014821:Vitrectomy
D000666:Amphotericin B