Late postoperative tamponade following coronary artery bypass grafting in patients on antiplatelet therapy.
Myocardial revascularization was performed in 1,361 patients over a 66-month period (February, 1978 to August, 1983) without a single occurrence of late cardiac tamponade. During a subsequent 4-month-period, aspirin and dipyridamole were administered routinely to all coronary bypass patients. The incidence of late cardiac tamponade rose significantly (p less than 0.001) to 3 of 85 patients (3.5%). Routine perioperative administration of aspirin and dipyridamole to patients undergoing myocardial revascularization may be associated with an increased incidence of delayed cardiac tamponade.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D002305:Cardiac Tamponade / Q000139:chemically induced*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004176:Dipyridamole / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011300:Preoperative Care
D004176:Dipyridamole; D001241:Aspirin