Progressive, predominantly motor, uraemic neuropathy.
A severe rapidly progressive neuropathy is described in 4 young male adults with end-stage renal failure, 3 of whom had accelerated hypertension. The onset of symptoms developed after regular haemodialysis had been started and in all 4 patients was closely associated with a septicaemic illness. In 2 patients, renal transplantation led to considerable clinical improvement, and in a third patient charcoal haemoperfusion halted further clinical progression of the neuropathy. This improvement was not reflected by the nerve conduction studies which remained grossly impaired. A possible ischaemic aetiology related to accelerated hypertension and septicaemia is suggested for this unusual variant of uraemic neuropathy.
D000293:Adolescent; D000328:Adult; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D009468:Neuromuscular Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006435:Renal Dialysis; D018805:Sepsis / Q000150:complications; D014511:Uremia / Q000150:complications* / Q000628:therapy