title: Treatment of infantile colic with surface active substance (simethicone).
abstract: The effect of Simethicone on "colicky" (n = 27) infants was tested in a double-blind cross-over study. Three different parameters were used to measure the efficiency of the treatment: interviews, 24-hour records and behavioral observations. No effects of Simethicone on the symptoms of infantile colic could be demonstrated. However, 67% of the infants improved during the treatment, which could be ascribed to a high-grade placebo-effect.
mesh_terms: D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012828:Silicones / Q000627:therapeutic use*; D012841:Simethicone / Q000627:therapeutic use*; D013501:Surface-Active Agents / Q000627:therapeutic use*
chemical_list: D012828:Silicones; D013501:Surface-Active Agents; D012841:Simethicone