[Complexes of monoclonal immunoglobulins of various classes with albumin and alpha 1-proteinase inhibitor].
Ability of monoclonal immunoglobulins (IgG, IgA, IgM and IgD) to develop complexes with albumin and alpha 1-proteinase inhibitor (alpha 1-PI) was studied using methods of immunoelectrophoresis, cross immunoelectrophoresis and immunoselection. High of proteins, producing complexes with albumin, was found among monoclonal IgA, IgM and IgG; alpha 1-PI formed complexes mainly with IgA and IgM. In healthy volunteers complexes of blood serum proteins were not found. Albumin and alpha 1-PI developed complexes most often with various molecules of monoclonal immunoglobulins. Ability to produce complexes did not depend on the type of the paraprotein.
D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000378:metabolism; D007072:Immunoglobulin D / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D066298:In Vitro Techniques; D010266:Paraproteins / Q000378:metabolism*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010266:Paraproteins; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin
Kompleksirovanie monoklonal'nykh immunoglobulinov raznykh klassov s al'buminom i alpha 1-ingibitorom proteaz.