Longitudinal study of HTLV-III-infected chimpanzees by lymphocyte subpopulation analysis.
Following inoculation with plasma from human patients with AIDS, two chimpanzees demonstrated specific antihuman T-cell leukemia virus type 3 (HTLV-III) antibodies. One of the two chimpanzees also developed massive lymphadenopathy that persisted for 32 weeks and demonstrated a concurrent and more frequent depression of total T cells (T3) and T helper cells (T4) with a decrease in the ratios of T4 to T suppressor cells (T8). These results indicate that chimpanzees demonstrate a range of T-cell subpopulations during infection and disease induced by HTLV-III.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000032:analysis*; D004195:Disease Models, Animal; D015483:HIV Antibodies; D008137:Longitudinal Studies; D008992:Monkey Diseases / Q000276:immunology*; D002679:Pan troglodytes / Q000382:microbiology*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D015483:HIV Antibodies