Immune monitoring of tumor development after renal transplantation.
A series of immune parameters were available covering the period before, during, and after tumor appearance in ten patients who developed tumors after renal transplantation. Results were obtained using monoclonal antibodies OKT3, OKT4, OKT8, and the ratio OKT4/OKT8, and surface membrane fluorescence microscopy (SMIg) for B-lymphocytes, E-rosetting and blast transformation. A much lower immune responder state was indicated at the time of transplantation in patients who later developed a tumor, as compared to a control group, and a much lower immune responder state was seen before than after tumor appearance. A low OKT4/OKT8 ratio was found before the diagnosis of Hodgkin's disease in one patient, and an increase in the immune responder state was seen after treatment of a patient developing spinocellular carcinoma at the site of a former herpes labialis. Using a monoclonal antibody against Hodgkin and Sternberg-Reed cells (Ki-1), it was possible to demonstrate that these were present before transplantation, with an increase before the appearance of the first clinical symptoms and, perhaps activated by the transplantation and the following immunosuppression, in the patient who developed Hodgkin's disease.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008213:Lymphocyte Activation; D008297:Male; D008722:Methods; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000209:etiology / Q000276:immunology*; D011183:Postoperative Complications / Q000175:diagnosis; D012397:Rosette Formation
D000911:Antibodies, Monoclonal