[Idiopathic nephrotic syndrome and the HLA allele. Prevalence of age-related DR7].
High prevalence of HLA DR7 was well documented in idiopathic nephrotic syndrome (INS) of childhood. Our data in 43 INS, child and adult patients, did not show any significant difference from control group, specially for HLA DR7. Moreover a significant difference occurred when the data was compared in child and adult INS patients. HLA DR7 was more frequent when the nephrotic syndrome appeared before 15 years old. There was no correlation between the presence of HLA DR7 and those of allergy history or increased serum IgE level, on the opposite with previous data. The presence of DR7 would favor its onset at an earlier age. Alternatively, the difference in DR7 prevalence could be an additional argument for considering that the corticosensitivity and negative histological criteria might collect, under the same name, different glomerulopathies.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000483:Alleles; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000276:immunology*; D010641:Phenotype
D006680:HLA Antigens; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II; D007073:Immunoglobulin E
Syndrome néphrotique idiopathique et allèle HLA. Prévalence de DR7 liée à l'âge.