Intracranial hemorrhage in utero due to isoimmune neonatal thrombocytopenia.
A case is presented of isoimmune neonatal thrombocytopenia complicated by spontaneous intracranial hemorrhage in utero. Maternal platelets were found to be negative for the PLA1, Baka, and HLA-A2 antigens. The present case demonstrates that the classical conservative approach of elective cesarean section can not guarantee against this crippling event.
D000328:Adult; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D002585:Cesarean Section; D004453:Echoencephalography; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D006680:HLA Antigens / Q000032:analysis; D015789:HLA-A2 Antigen; D006801:Humans; D007231:Infant, Newborn; D039661:Integrin beta3; D007518:Isoantibodies / Q000032:analysis; D007519:Isoantigens / Q000032:analysis; D008297:Male; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology*; D014057:Tomography, X-Ray Computed
C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D006680:HLA Antigens; D015789:HLA-A2 Antigen; C061248:ITGB3 protein, human; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens