title: Transdermal clonidine in the treatment of adolescent hypertension.
abstract: The effectiveness of transdermally administered clonidine in normalizing blood pressure in 22 adolescents with sustained diastolic hypertension was studied. The clonidine transdermal device consisted of an adhesive disc which delivered a low, but continuous, dose of drug through the skin for at least 1 week. Following a placebo disc, subjects received clonidine with increasing titration every 2 weeks until blood pressure reduction goals (90th percentile) were achieved. In 21 of 22 subjects blood pressure goals were achieved and maintained for 8 weeks of stable dose. Side effects were minimal.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D003000:Clonidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male
chemical_list: D003000:Clonidine