title: [Juvenile chronic arthritis. Double-blind study of the efficacy and tolerance of D-penicillamine].
abstract: Seventy-four children with juvenile chronic arthritis were admitted to a 6-month multicentric double blind comparative study of the efficiency of D-Penicillamine or placebo. The results evaluated in 55 patients who completed the study, indicated an improvement in the total number of stiff joints and in the total index of severity measuring joint pain and inflammation. A significant reduction of the concurrent use of non steroidal antiinflammatory drugs was also observed. The tolerance was good except in two patients. Some children in the placebo group exhibited a definite improvement.
mesh_terms: D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010396:Penicillamine
vernacular_title: Arthrite chronique juvénile. Etude en double insu de l'efficacité et de la tolérance de la D-pénicillamine.