Adenosine deaminase inhibitors enhance cerebral anoxic hyperemia in the rat.
Cerebral blood flow in the rat was monitored by a venous outflow technique with an extracorporeal circulation, which allows for the continuous recording of flow over periods of several hours. The adenosine deaminase inhibitors erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) (1.0-100 micrograms/kg) and deoxycoformycin (0.1-1 micrograms/kg) potentiated the reactive hyperemia elicited by a brief (24-s) anoxic challenge. Basal flow rate was unaltered by EHNA administration and slightly enhanced by deoxycoformycin. The results are consistent with the hypothesis that adenosine plays a significant role in cerebral vascular regulation and suggest that low doses of these deaminase inhibitors may be useful in the treatment of cerebral vascular insufficiency.
D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003070:Coformycin / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D006940:Hyperemia / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000378:metabolism*; D008297:Male; D015649:Pentostatin; D051381:Rats; D011919:Rats, Inbred Strains; D012263:Ribonucleosides / Q000494:pharmacology*
D058892:Adenosine Deaminase Inhibitors; D012263:Ribonucleosides; D003070:Coformycin; D015649:Pentostatin; C010192:9-(2-hydroxy-3-nonyl)adenine; D000225:Adenine