Evidence that PGI2-generation in human dental cysts is stimulated by leucotrienes C4 and D4.
Various prostaglandins, particularly PGE2 and PGI2, appear to play a major role in osteolytic processes. The bone-destructive action of dental squamous cell cysts is thought to be caused or at least mediated by prostaglandins. Both leucotrienes and prostaglandins are synthesized from a common precursor substance, i.e. arachidonic acid, in a series of reactions. There is a special relation between leucotrienes and PGI2 in that PGI2 synthesis in endothelial cells can be enhanced by LTC4 and LTD4. R-TLC showed conversion of the arachidonic acid added into PGI2 in 8 out of 12 cases, as reflected by the stable degradation product 6-oxo-PGF1 alpha. In 8 cases bioassay showed PGI2 synthesis without addition of LTC4 and LTD4. Incremental LTC4 and LTD4 additions were found to cause a highly significant increase of PGI2 synthesis rates. In summary, LTC4 and LTD4 stimulate PGI2 synthesis in chronic inflammatory processes in vivo and may thus elicit or accelerate osteolysis.
D001095:Arachidonic Acids / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003803:Dentigerous Cyst / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D010014:Osteolysis / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology* / Q000502:physiology; D013268:Stimulation, Chemical
D001095:Arachidonic Acids; D013189:SRS-A; D011464:Epoprostenol