Varicella in immunodepressed children.
Although dramatic improvements in the treatment of childhood malignancies have occurred during the last 20 years, infections occurring while they are on immunosuppressive chemotherapy now pose increasing problems for these patients. The literature on the subject and two personal illustrative fatal cases of varicella-zoster infections are reviewed pointing out the need for better prophylactic and antiviral therapy in this susceptible patient population.
D000971:Antineoplastic Combined Chemotherapy Protocols; D002644:Chickenpox / Q000150:complications / Q000276:immunology*; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007165:Immunosuppression Therapy; D007945:Leukemia, Lymphoid / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D011241:Prednisone; D008727:Methotrexate