Immunologic identification of both plasma and human renal inactive renin as prorenin.
Antibodies were raised against a synthetic tetradecapeptide which is a component of the non-renin portion (prosegment) of human renin precursor. Inactive renin from human kidney and plasma strongly adsorbed to a gel coupled to immunoglobulins purified from such an antiserum. These results suggest that renal and circulating inactive human renins contain in their structure the prosegment of prorenin.
D000918:Antibody Specificity; D002846:Chromatography, Affinity; D004792:Enzyme Precursors / Q000032:analysis* / Q000097:blood; D006801:Humans; D007120:Immunochemistry; D007668:Kidney / Q000201:enzymology*; D012083:Renin / Q000032:analysis* / Q000097:blood
D004792:Enzyme Precursors; D012083:Renin