title: Chromosomal localization of the human alpha 1-antitrypsin gene (PI) to 14q31-32.
abstract: In situ hybridization of a recombinant cDNA probe containing the human alpha 1-antitrypsin gene to metaphase chromosomes demonstrated significant hybridization to chromosomal segment 14q31-32. A high percentage of cells analyzed (31%) displayed labeling on chromosome 14. Of all labeled sites on chromosome 14, 60% were found on segment 14q31-32. These results refine the previous assignment of the human alpha 1-antitrypsin gene to segment 14q24.1-32.1.
mesh_terms: D002871:Chromosome Banding; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D004247:DNA / Q000235:genetics; D004274:DNA, Recombinant; D005796:Genes; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D010957:Plasmids; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D004274:DNA, Recombinant; D000515:alpha 1-Antitrypsin; D004247:DNA