title: Regression of lymphosarcoma by treatment with acetylsalicylic acid in rats.
abstract: Increased synthesis of prostaglandins (PGs) may be an important promoting factor in the development of lymphosarcoma. Thus, inhibition of PG synthesis may represent a logical way of controlling the growth of lymphosarcomatous cells. In order to verify this hypothesis, two groups of rats with lymphosarcoma have been used: the test-group received acetyl salicylic acid (54 mg/animal/day) and the control-group received the same quantity of physiological saline solution. After 4 days of treatment, the lymph nodes stopped growing in the test-group. Microscopic and electron microscopic examinations of lymph node sections were carried out after 11 days of treatment. These showed for the test-group the disappearance of the characteristics of malignancy.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000970:Antineoplastic Agents; D001241:Aspirin