Lymphocyte subsets in HLA-DR2-positive narcoleptic patients.
On the basis of our recent finding that all narcoleptic patients were HLA-DR2 positive, peripheral blood lymphocyte subsets were examined in 30 HLA-DR2 positive narcoleptic patients by using monoclonal antibodies and a flow cytometry. The percentages of OKIa1+ cells and OKM1+ cells increased significantly, while no quantitative changes were observed in the T cell subsets examined in the present study. No major immunological abnormalities which altered the T cell subpopulations quantitatively were apparent in narcolepsy.
D000328:Adult; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015802:HLA-DR2 Antigen; D000949:Histocompatibility Antigens Class II