HLA and lymphocyte receptors for gliadin peptides.
Coeliac disease is associated with the HLA Class I antigens A1 and B8 as well as with Class II antigens D/DR3, 7 and DC3. Class I antigens are important in the process of self recognition, guiding the cytolytic action of T killer cells, whereas Class II antigens are thought to regulate the functions of T helper and suppressor lymphocytes, and may be have a role in the intracellular transport of foreign macromolecules. Gliadin fractions were observed to adhere to the surface of B lymphocytes of patients with coeliac disease. The phenomenon was independent of the HLA antigen status (A, B, C, DR) of the patients, suggesting that the receptor for gliadin on the B cell surface is a yet unidentified B cell surface marker.
D001402:B-Lymphocytes / Q000276:immunology; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D005903:Gliadin / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D010940:Plant Proteins / Q000276:immunology*; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell / Q000032:analysis*; D011971:Receptors, Immunologic / Q000032:analysis*; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D010940:Plant Proteins; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D011971:Receptors, Immunologic; C032193:glycoprotein receptor GPIb-IX; D005903:Gliadin