Phaeochromocytoma: a review of the St Vincent's Hospital, Melbourne experience (1969-84) and of recent advances in management.
Phaeochromocytoma is an unusual tumour which is eminently curable by surgical means. It is difficult to diagnose clinically because it mimics other illnesses. The clinical features of 13 cases of phaeochromocytoma diagnosed at St Vincent's Hospital, Melbourne, between 1969 and 1984 are briefly described. This review emphasizes the several major improvements in both diagnostic and localizing tests which have occurred over the 16 year period of the series. These include the clonidine suppression test and plasma and urine catecholamine estimations in diagnosis and techniques such as CT scanning and the I131-meta-iodobenzyl-guanidine scan used for localization of the tumour. Careful pre-operative preparation, based on adequate alpha blockade and intra-operative monitoring, is essential for the safe and successful removal of the tumour, which was eventually accomplished for all 12 cases in which removal was attempted. However, the most important step in the diagnosis and treatment of phaeochromocytoma is the initial consideration of the diagnosis. This step depends on the level of awareness of the disorder amongst clinicians.
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000601:surgery* / Q000652:urine; D000328:Adult; D000758:Anesthesia; D002395:Catecholamines / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000628:therapy; D008297:Male; D008722:Methods; D008875:Middle Aged; D010643:Phenoxybenzamine / Q000008:administration & dosage; D010673:Pheochromocytoma / Q000175:diagnosis / Q000601:surgery* / Q000652:urine; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis / Q000601:surgery / Q000652:urine; D011300:Preoperative Care
D002395:Catecholamines; D010643:Phenoxybenzamine