title: Effect of hypobaric hypoxia on spermatogenesis, Leydig cells and delta 5-3 beta-hydroxysteroid dehydrogenase activity in toad.
abstract: The effect of different grades of hypobaric hypoxia for 48 hours was studied on spermatogenesis, Leydig cells and delta 5-3 beta-hydroxysteroid dehydrogenase activity in toad (Bufo melanostictus). Maximum inhibition of testicular activity was noted in 7,315 m exposed animals. The impairment of testicular function at high altitude is possibly due to inhibition of gonadotrophin secretion.
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000531:Altitude; D000818:Animals; D001274:Atmospheric Pressure; D002025:Bufonidae; D000860:Hypoxia / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D013091:Spermatogenesis; D013737:Testis / Q000201:enzymology / Q000473:pathology*
chemical_list: D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase