The effect of captopril on renal function in patients during the first cis-diamminedichloroplatinum II infusion.
On the assumption that hemodynamic changes in renal blood flow are the initial expression of cis-diamminedichloroplatinum (CDDP)-related nephrotoxicity, we treated patients with metastatic non-seminomatous testicular carcinoma during CDDP infusion with captopril. This angiotensin-converting enzyme inhibitor significantly attenuated the initial decrease in effective renal plasma flow and can probably be used to protect the kidneys against CDDP-induced nephrotoxicity.
D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000494:pharmacology*; D002945:Cisplatin / Q000009:adverse effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D012079:Renal Circulation / Q000187:drug effects
D011392:Proline; D002216:Captopril; D002945:Cisplatin