Ex vivo model for pre-clinical evaluation of dialyzers containing new membranes.
The ex vivo model which reflects hemodialysis modulating factors during the first twenty minutes of blood membrane interaction, is applicable as a pre-clinical test for new membranes. The biocompatibility of a new cellulosic membrane (MC) proved to be superior to regenerated cellulose and comparable to synthetic membranes such as PAN regarding complement activation.
D002482:Cellulose; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D015926:Complement C3a; D006801:Humans; D066298:In Vitro Techniques; D007688:Kidneys, Artificial / Q000009:adverse effects; D008422:Materials Testing / Q000379:methods*; D010978:Platelet Factor 4 / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000097:blood
D003176:Complement C3; D010978:Platelet Factor 4; D013929:Thromboxane B2; D015926:Complement C3a; D002482:Cellulose