[Non-protein sulfhydryl groups and glutathione-S-transferases in acute toxic effects of Di-n-alkyltin dichlorides in mice and rats].
Toxic doses of di-n-butyl-tinn-dichloride (DBTC, 1.6 mmol/kg p.o., 0.04 mmol/kg i.v.) and of di-n-octyl-tinn-dichloride (DOTC, 2.4 mmol/kg p.o.) did not affect the non-protein sulfhydryl groups (NPSH) in mice livers. The NPSH depletion by a diethylmaleate pre-treatment did not influence acute toxic DOTC effects on the rats' thymus. DBTC concentrations of 10(-5) to 10(-4) mol/l in vitro inhibited the glutathion-S-transferase activity (GSH-Trs.) of cytosolic supernatants from the liver and the thymocytes of the rat compared with 1-chloro-2,4-dinitrobenzen as the electrophile substrate by max. 34%. The GSH-Trs. in the cytosolic liver supernatant had not been reduced after rats' DBTC treatment. A hydrophobic DBTC binding to GSH-Trs. is supposed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects; D051379:Mice; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D013045:Species Specificity; D013438:Sulfhydryl Compounds / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects
D009947:Organotin Compounds; D013438:Sulfhydryl Compounds; D005982:Glutathione Transferase; C020735:dibutyldichlorotin; C020297:di-n-octyltin dichloride
Nichtprotein-Sulfhydrylgruppen und Glutathion-S-transferasen bei akuten toxischen Wirkungen von Di-n-alkylzinndichloriden an Mäusen und Ratten.