Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression.
Two mRNAs generated as a consequence of alternative RNA processing events in expression of the human calcitonin gene encode the protein precursors of either calcitonin or calcitonin gene-related peptide (CGRP). Both calcitonin and CGRP RNAs and their encoded peptide products are expressed in the human pituitary and in medullary thyroid tumors. On the basis of sequence comparison, it is suggested that both the calcitonin and CGRP exons arose from a common primordial sequence, suggesting that duplication and rearrangement events are responsible for the generation of this complex transcription unit.
D001483:Base Sequence; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010902:Pituitary Gland / Q000032:analysis; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000032:analysis
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide