title: Antidepressant drugs and migraine.
abstract: There is evidence that some antidepressant drugs, above all amitriptyline and mianserine, are beneficial in the prophylaxis of migraine. The mechanism of action of antidepressants in migraine is likely to be complex. Mood disturbances accompanying migraine syndromes suggest a mode of action of such a class of drugs. In the last few years some clinical studies tend to show that the antimigraine effects of these drugs seem relatively independent of the antidepressant activity.
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000494:pharmacology / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003863:Depression; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000494:pharmacology / Q000627:therapeutic use; D008881:Migraine Disorders / Q000188:drug therapy* / Q000523:psychology; D009619:Nociceptors / Q000187:drug effects; D011897:Random Allocation
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D008803:Mianserin