title: Benign and malignant lymphocytic skin infiltrates: immunological patterns recognized by immunohistochemical staining with monoclonal antibodies.
abstract: Skin biopsies from 150 patients with cutaneous lymphoma, premalignant or "pseudolymphomatous" conditions and benign dermatoses were examined by immunoenzymatic staining of frozen sections with a panel of monoclonal antibodies against lymphocytes, macrophages and accessory cells. Two patterns of infiltration were identified. In one of these T cells associated with Langerhans cells and HLA-DR-positive macrophages of dendritic morphology, were seen. In the other B cell follicles were present in addition to the above type of infiltrate. The latter pattern was restricted to patch tests biopsies, cutaneous lymphocytomas, and malignant lymphomas of B-cell origin. It is concluded that lymphocytic skin infiltrates are divisible into different patterns of immunological reactions similar to those seen in lymphoid organs.
mesh_terms: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface