Extravascular lung water: effects of intravenous ionic and non-ionic (lopamidol) contrast media during ischemia.
Intravenous injections of ionic contrast media increase extravascular lung water in patients with elevated left atrial pressure, particularly in the presence of myocardial ischemia. The authors compared bolus injections of sodium methylglucamine diatrizoate and iopamidol on extravascular lung water at several levels of left atrial pressure in dogs. Methylglucamine increased lung water by a maximum of approximately 25-30% above baseline levels at low (less than 3 mm Hg), moderate (approximately equal to 15 mm Hg), and elevated left atrial pressures (greater than or equal to 25 mm Hg). At matched pressures, the peak change in lung water in the dogs given iopamidol was +4%, +7%, and +6%, respectively. In dogs with myocardial ischemia, the differences were even more pronounced (+45%, +60%, and +70%, respectively, for ionic media, and +7%, +12%, and +21% for iopamidol). The authors caution against using ionic contrast media in patients with left ventricular dysfunction, particularly associated with ischemia. In such cases, non-ionic media appear safer.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002302:Cardiac Output; D003287:Contrast Media / Q000633:toxicity*; D003327:Coronary Disease / Q000503:physiopathology*; D003973:Diatrizoate / Q000031:analogs & derivatives* / Q000633:toxicity*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004285:Dogs; D004338:Drug Combinations; D005110:Extracellular Space / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D012306:Risk; D013268:Stimulation, Chemical
D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; C027278:urovision; D007479:Iopamidol