title: Cumulative experience with propofol ('Diprivan') as an agent for the induction and maintenance of anaesthesia.
abstract: In 60 unpremedicated patients, anaesthesia induction time decreased when the time taken to inject a bolus of 2 mg/kg propofol was decreased from 60 s to 5 s. Apnoea at induction was noted in all groups but the degree of cardiorespiratory depression was not influenced by the rate of injection. In premedicated patients both 1.5 mg/kg and 2.0 mg/kg were effective doses for induction of anaesthesia. In comparison with thiopentone 4 mg/kg, propofol produced a greater degree of arterial hypotension and a smaller increase in heart rate. Preliminary results with an infusion of propofol for maintenance of anaesthesia suggest that rapid recovery can be achieved after operations of long duration.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010038:Otorhinolaryngologic Diseases / Q000601:surgery; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects; D015742:Propofol; D013874:Thiopental / Q000009:adverse effects; D013997:Time Factors
chemical_list: D010636:Phenols; D013874:Thiopental; D015742:Propofol