The use of pressimmune in renal transplantation: a four-year study.
Over a three year period, 22 diabetic and 87 non-diabetic patients received 120 cadaver kidney transplants at Dulwich Hospital. Horse antilymphocyte globulin (ALG), azathioprine and low-dose intra-muscular methyl prednisolone were used as immunosuppressive agents. A control group of 98 non-diabetic patients (113 transplants) at Guy's Hospital during the same period were treated with a standard azathioprine and oral steroid regime. Four main findings emerged: Firstly, survival rates for first grafts in the non-diabetic patients were similar in both centers. This suggests that neither the ALG or more conventional immunosuppressive regime holds any advantage in this patient group. Secondly, the first grafts in diabetic patients did significantly worse than similar grafts in the non-diabetics. Thirdly, in patients receiving the more conventional regime, second grafts did significantly worse than first grafts. Fourthly, and in contrast, the ALG regime gave similar survival figures for both first and second grafts. Thus, ALG had no apparent advantage over conventional steroid regimes on the survival of first grafts but it did produce a marked improvement in the outcome of subsequent grafts.
D000328:Adult; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001379:Azathioprine / Q000494:pharmacology; D003928:Diabetic Nephropathies / Q000601:surgery; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006736:Horses / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology; D012086:Reoperation
D000961:Antilymphocyte Serum; D011239:Prednisolone; D001379:Azathioprine; D008775:Methylprednisolone