title: PGE2 gel for enhancement of priming and induction of labour at term in patients with unfavorable cervix.
abstract: Fifty women (25 nulliparae and 25 multiparae) with unfavorable cervix at term were enrolled in a clinical experiment to evaluate the safety and efficacy of the intracervical application of 0.5 mg PGE2 gel for cervical softening and eventual induction of labour; duration of pregnancy (38-42 wk) was confirmed by ultrasonic records. Global analysis revealed 48 (96%) vaginal deliveries, 43 (86%) being spontaneous labour and 5 (10%) instrumentally assisted deliveries (forceps). Caesarean section was required in 2 cases (4%). Three patients, having registered no Bishop score (above 5) progress after the first treatment, went into labour upon the second application of PGE2 gel. Mean induction-delivery time was 11 h 50 min for nulliparae and 7 h 50 min for multiparae. Mean ROM/amniotomy-delivery time was 5 h 59 min for nulliparae and 3 h 11 min for multiparae. Four neonates with initial Apgar scores below 7 registered immediately higher values after adequate reanimation manouvres.
mesh_terms: D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000503:physiopathology*; D015232:Dinoprostone; D005260:Female; D005782:Gels; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D007744:Obstetric Labor Complications / Q000188:drug therapy; D010298:Parity; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors; D014215:Triacetin
chemical_list: D005782:Gels; D011458:Prostaglandins E; D015232:Dinoprostone; D014215:Triacetin