title: Naloxone reversal of stress-induced reproductive effects in the male rhesus monkey.
abstract: Adolescent male rhesus monkeys, stressed by placement in tethering systems, were administered naloxone to discern the involvement of endogenous opioids in the stress-induced reproductive dysfunction. Stressed monkeys exhibited decreased plasma levels of luteinizing hormone (LH), testosterone, and increased levels of prolactin. Administration of naloxone temporarily returned hormone levels to non-stressed values. Stress depressed sexual activity was increased following naloxone treatment. GnRH administration stimulated plasma LH and testosterone levels. These results indicate that stress-induced changes in reproductive function may be mediated by opioids at levels above the pituitary.
mesh_terms: D000818:Animals; D004723:Endorphins / Q000502:physiology*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin / Q000097:blood; D012735:Sexual Dysfunction, Physiological / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
chemical_list: D004723:Endorphins; D010906:Pituitary Hormone-Releasing Hormones; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone