title: [Age-related pathomorphism of diabetes mellitus].
abstract: Insulin supply of the body, activity of hormonal and nonhormonal insulin antagonists were studied and compared in subjects of different age with disordered carbohydrate tolerance. The role of hormonal and non-hormonal antagonists in the genesis of glucose intolerance was found to be different in different age periods in the presence of hyperinsulinemia and the reduced insulin-glucose index common to all the groups examined. Young age is marked by a distinct increase in glucocorticoid and, to a less degree, in androgenic functions of the adrenals. The elderly manifest activation of the angiotensin-renin-aldosterone system and more pronounced hypercholesterolemia and triglyceridemia in the presence of the changed body sensitivity to insulin. It is suggested that age-associated changes in the mechanisms of the glucose homeostasis control may be of importance in the formation of the features of individual patterns of diabetes mellitus.
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000502:physiology; D000311:Adrenal Glands / Q000503:physiopathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D050260:Carbohydrate Metabolism; D002648:Child; D003920:Diabetes Mellitus / Q000209:etiology*; D006801:Humans; D007328:Insulin / Q000172:deficiency; D007333:Insulin Resistance; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D010908:Pituitary Hormones, Anterior / Q000502:physiology; D011236:Prediabetic State / Q000209:etiology*
chemical_list: D000305:Adrenal Cortex Hormones; D007328:Insulin; D010908:Pituitary Hormones, Anterior
vernacular_title: K voprosu o vozrastnom patomorfoze sakharnogo diabeta.