Effect of prostaglandin E2 on serum iron after acute and chronic blood loss.
The effect of prostaglandin E2 on serum iron of New Zealand rabbits subjected to acute and chronic blood loss is demonstrated. The results showed that acute blood loss was followed by significant elevation of serum iron when sera were tested on day three after the bleeding. With subcutaneous injection of 40 micrograms/kg body weight of prostaglandin E2 for each 12 h of the experiment, acute blood loss was followed by a significant reduction in serum iron within the same period. Similar results were obtained after chronic blood loss when subcutaneous injection of 20 micrograms/kg body weight of prostaglandin E2 was used for each 12 h of the experiment. It could be concluded that the prostaglandin E2 causes marked lowering of serum iron following blood loss.
D000818:Animals; D015232:Dinoprostone; D006470:Hemorrhage / Q000097:blood*; D007501:Iron / Q000097:blood*; D011458:Prostaglandins E / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D011458:Prostaglandins E; D007501:Iron; D015232:Dinoprostone