title: Toxicokinetics of the herbicide dichlorprop and its leucinate and their action on liver mixed function oxidase in rats.
abstract: The concentrations of dichlorprop and its leucine conjugate in serum and bile of rats have been determined at different periods after a single oral dosage of these compounds (30 or 300 mg/kg body weight). From the results it can be concluded that dichlorprop is excreted by active renal mechanisms resembling that described for 2,4,5-T. It is suggested that the leucinate is excreted more by the biliary route. Investigations of the liver demonstrate that both compounds are able to induce mixed function oxidases.
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001646:Bile / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007930:Leucine / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: C047793:dichlorprop-leucine conjugate; D015084:2,4-Dichlorophenoxyacetic Acid; D006899:Mixed Function Oxygenases; D007930:Leucine; C010571:dichlorprop