title: B-cell lymphoma in two monogamous homosexual men.
abstract: Opportunistic infections and malignant neoplasms have been described in homosexual men in association with immunologic abnormalities. We observed the development of malignant B-cell lymphomas in two homosexual men who had had a monogamous relationship for two years. Patient 1 had an aggressive, monoclonal, small, noncleaved, non-Burkitt's lymphoma ("undifferentiated lymphoma"), associated with severe immunocompromise. Patient 2 manifested a monoclonal, small, cleaved, follicular center cell lymphoma, with a follicular pattern, two months later. No common acute infection was detected. Staining for Epstein-Barr nuclear antigen in malignant tissue was negative in the second patient. However, the possibility of a transmissible agent as a causative factor cannot be excluded, and further study of similar patients is warranted.
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000276:immunology / Q000473:pathology*; D006716:Homosexuality; D006801:Humans; D006965:Hyperplasia; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000209:etiology / Q000473:pathology*; D008297:Male; D008339:Mandibular Neoplasms / Q000276:immunology / Q000473:pathology*