Osteopenia and circulating levels of vitamin D metabolites in diabetes mellitus.
The degree of diabetic osteopenia and serum vitamin D metabolite levels were measured in 14 type 1 (insulin-dependent) and 168 type 2 (non-insulin-dependent) diabetic patients. Based on six indices obtained by microdensitometry, we found the bone mass in 28.6% of type 1 and 26.2% of type 2 diabetic patients to be decreased and in 14.3% and 11.9%, respectively, the decrease was severe. Our method of analysis of bone mass has shown that diabetic osteopenia differs from typical osteoporosis in character. In addition, serum 24,25-dihydroxyvitamin D was significantly decreased both in type 1 and in type 2 diabetes (p less than 0.01), but 1,25-dihydroxyvitamin D was significantly decreased only in type 1 diabetes (p less than 0.01) compared to the controls, being lower than that in type 2 diabetes (p less than 0.05). On the other hand, 25-hydroxyvitamin D was similar to that of the controls, in both types of diabetes.
D015650:24,25-Dihydroxyvitamin D 3; D000293:Adolescent; D000328:Adult; D000368:Aged; D001847:Bone Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*
D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D002112:Calcifediol