title: Electrochemistry of purine derivatives. 1: Direct determination for the antiviral drug 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine by anodic differential pulse voltammetry.
abstract: Differential pulse voltammetry at a stationary glassy carbon electrode was used for the sensitive and selective analysis of a potent new antiviral analogue of 2-deoxyguanosine in a pharmaceutical formulation. In the electrochemical method for analysis of 9-[1,(3-dihydroxy-2-propoxy)methyl] guanine (1), an electroactive internal standard (uric acid) was used. Linear peak current-concentration relationships were obtained at 1 concentrations of 0.4-2.0 mM, with a quantitation limit of 0.1 mM. Degraded solutions of 1 were assayed directly by differential pulse voltammetry and also by two chromatographic methods to demonstrate the specificity of the electrochemical method. The voltammetric method reliably provides accurate and reproducible results in considerably less time than conventional chromatographic analysis.
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000032:analysis; D000998:Antiviral Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004563:Electrochemistry; D004566:Electrodes; D015774:Ganciclovir; D006863:Hydrogen-Ion Concentration; D011687:Purines / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014527:Uric Acid
chemical_list: D000998:Antiviral Agents; D011687:Purines; D014527:Uric Acid; D015774:Ganciclovir; D000212:Acyclovir