[Synthesis and pharmacologic activity of 2-arylethenylthiazol-4-acetic and 4-carboxylic acids].
Two new series of 2-aryletenylthiazolo-4-acetic (IV-XII) and 4-carboxylic (XIII-XXI) acids substituted with alkoxy groups in the benzene ring were synthesized. The compounds were subjected to comparative tests of antiinflammatory, analgesic and antipyretic activity.
D000085:Acetates / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002264:Carboxylic Acids; D013844:Thiazoles
Sintesi e attività farmacologica di acidi 2-arileteniltiazol-4-acetici e 4-carbossilici.