Chemical and antigenic alterations of Candida albicans cell walls related to the action of amphotericin B sub-inhibitory doses.
Sub-inhibitory doses of amphotericin B led to Candida albicans cell wall modifications which involved peptidomannans. The amount of this product was reduced by a third, the decrease being due to mannans whose absolute and relative values fell whereas the amount of amino-acids increased. Concomitantly, the treated cells exhibited a loss in their immunological reactivity.
D000596:Amino Acids / Q000032:analysis; D000666:Amphotericin B / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000276:immunology; D002473:Cell Wall / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D008351:Mannans / Q000276:immunology / Q000378:metabolism; D010457:Peptidoglycan / Q000276:immunology / Q000378:metabolism
D000596:Amino Acids; D008351:Mannans; D010457:Peptidoglycan; D000666:Amphotericin B