[Characteristics of beta 2-adrenergic regulation of gastric secretion, hemostasis and cardiac rhythm in patients with duodenal ulcer and a history of hemorrhagic complications (effect of alupent)].
The effect of intravenous infusion of alupent (0.1 microgram/kg/min for 1 h) on the main parameters of gastric secretion, thromboelastogram, electrocoagulogram, ADP-induced platelet aggregation, the kinetics of fibrinolysis and vegetative regulation of the cardiac rhythm was studied in 59 subjects (10 healthy males, 23 patients suffering from peptic ulcer of the duodenum with a history of hemorrhages, 26 patients with uncomplicated duodenal ulcer). In healthy subjects and in patients with uncomplicated ulcer, the beta 2-adrenoagonist caused an increase in the volume of basal secretion, production of acid and pepsin, acceleration of blood coagulation, and fibrinolysis activation. At the same time in 2/3 of patients with a history of hemorrhages due to duodenal ulcer alupent inhibited gastric secretion of acid and pepsin and, along with stimulation of plasmic factors of coagulation, inhibited activated fibrinolysis. Vegetative dysfunction in patients with uncomplicated ulcer was marked by the predominance of the parasympathetic regulation of the cardiac rhythm, whereas in patients with a history of hemorrhages by sympatheticotonia. These features of beta 2-adrenergic regulation can be used for predicting hemorrhages and development of pathogenetically validated treatment methods.
D000328:Adult; D000897:Anti-Ulcer Agents; D001777:Blood Coagulation / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009921:Metaproterenol / Q000627:therapeutic use*; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D009921:Metaproterenol
Osobennosti beta 2-adrenergicheskoĭ reguliatsii zheludochnoĭ sekretsii, hemostaza i serdechnogo ritma u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki s gemorragicheskimi oslozhneniiami v anamneze effekty alupenta).