Enhanced sensitivity of Escherichia coli umuC to photodynamic inactivation by angelicin (isopsoralen).
Escherichia coli umuC cells were inactivated four times more rapidly than umuC+ cells by angelicin (a monofunctional psoralen) plus near-UV irradiation. With other DNA-damaging treatments, either no or much smaller differences in sensitivity were observed. These results show that functions associated with the UmuC+ phenotype contribute to the repair (or tolerance) of some categories of DNA damage more efficiently than others.
D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects; D011564:Furocoumarins / Q000494:pharmacology*; D007364:Intercalating Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D011564:Furocoumarins; D007364:Intercalating Agents; C011659:angelicin