title: Regulation of the expression of a mammalian idiotype in chickens.
abstract: Id-1, an idiotype associated with rat anti-Group A streptococcal carbohydrate (anti-SACHO) antibodies has not been detected in any other tested species immunized with Group A streptococcal vaccine (GASV). The immunization of chickens with rat Id-1 prior to challenge with GASV, however, induced the production of Id-1 and anti-Id-1 in some chickens. The concentrations of both idiotype and anti-idiotype were regulated by challenges with GASV. Thus, it appears that this non-mammalian species has the genetic potential to express the mammalian Id-1 network but such a potential is normally masked by regulatory pressures.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D005786:Gene Expression Regulation; D007114:Immunization; D007130:Immunoglobulin Idiotypes / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D010802:Phylogeny; D011135:Polysaccharides, Bacterial / Q000276:immunology; D051381:Rats; D013297:Streptococcus pyogenes / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001428:Bacterial Vaccines; D007130:Immunoglobulin Idiotypes; D011135:Polysaccharides, Bacterial; C036112:streptococcal polysaccharide group A