Measurement of meperidine-induced respiratory depression using a new non-invasive technique.
Inductive plethysmography was used to assess the magnitude and duration of respiratory depression caused by doses of meperidine commonly administered during dental intravenous sedation. Minute volume measurements exhibited a high degree of accuracy when compared to simultaneous spirometry. Intravenously administered meperidine 25 mg/70 kg and 50 mg/70 kg both caused a significant shift to the right in their respective ventilatory-pco(2) response curves. The magnitude and duration of this respiratory depression was dose related. Even relatively low doses of meperidine used in dental intravenous sedation cause respiratory depression.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000009:adverse effects*; D010991:Plethysmography / Q000379:methods; D012120:Respiration Disorders / Q000139:chemically induced / Q000175:diagnosis*
D008614:Meperidine