title: The effect of high-dose fentanyl anaesthesia on P50 in man.
abstract: The effect of high dosage fentanyl anaesthesia on P50 was studied in patients undergoing coronary bypass surgery. After induction of fentanyl anaesthesia 100 micrograms X kg-1 with pancuronium muscle relaxation P50 changed significantly (P less than 0.005) from 3.40 +/- 0.12 to 3.33 +/- 0.13 kPa. This anaesthesia technique decreases P50 in vivo, but this has more theoretical than practical importance.
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D002263:Carboxyhemoglobin / Q000032:analysis; D001026:Coronary Artery Bypass; D004305:Dose-Response Relationship, Drug; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000032:analysis; D010313:Partial Pressure
chemical_list: D010108:Oxyhemoglobins; D008706:Methemoglobin; D002263:Carboxyhemoglobin; D010100:Oxygen; D005283:Fentanyl