Lymphocyte stimulation in Reiter's syndrome. A comparative study between patients and normal controls with special reference to HLA-B27.
The lymphocyte-stimulating capacity of bacterial antigens from Yersinia enterocolitica and Chlamydia trachomatis was studied in 14 patients with Reiter's syndrome and compared with 16 healthy controls. The influence of HLA-B27 was evaluated. There was an increased reactivity in patients compared with controls. The most pronounced reactivity was seen in HLA-B27-positive patients. These findings support the hypothesis that there is an impaired T-cell function in HLA-B27-associated diseases.
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D016918:Arthritis, Reactive / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015008:Yersinia enterocolitica / Q000276:immunology
D000942:Antigens, Bacterial; D006680:HLA Antigens; D015796:HLA-B27 Antigen