Cushing's syndrome: current status.
The evolution of ideas concerning the aetiology of Cushing's syndrome over the past 70 years is reviewed briefly. It is now agreed that about 70% of patients have a pituitary adenoma, not necessarily basophil, the removal of which results in remission but follow-up is currently too short for assessment of ultimate cure. Whether or not the pituitary lesion is primary or secondary to events in the cerebrum or brainstem is discussed, but a definite answer cannot be given at present.
D000236:Adenoma / Q000150:complications; D000306:Adrenal Cortex Neoplasms / Q000150:complications; D003346:Corticotropin-Releasing Hormone / Q000097:blood; D003480:Cushing Syndrome / Q000209:etiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications
D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone