title: [The action of potassium orotate in prophylactic and therapeutic administration to irradiated rats].
abstract: A study was made of the radioprotective and therapeutic effect of potassium orotate on rats subjected to whole-body gamma-irradiated with doses of 11, 9 and 4 Gy. The preparation exerted a radioprotective action when administered intraperitoneally 60 min before irradiation as was estimated with a reference to the survival rate and leukocyte level in the peripheral blood. Fron the analysis of the peripheral blood consumption it was inferred that potassium orotate weakened the radiation damage and enhanced the recovery processes during the postirradiation period.
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects; D007958:Leukocyte Count; D008297:Male; D009963:Orotic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D051381:Rats; D013997:Time Factors; D014916:Whole-Body Irradiation
chemical_list: D009963:Orotic Acid
vernacular_title: Osobennosti deĭstviia orotata kaliia pri profilakticheskom i lechebnom vvedenii obluchennym krysam.