Improvement of bioavailability of poorly absorbed drugs. III. Oral acute toxicity and local irritation of medium chain glyceride.
Oral acute toxicity of medium chain glyceride (MCG) was studied in mice and rats. In mice and rats, clinical signs such as irregular respiration, laxity of movement, staggering gait and loss of righting reflex appeared after single oral administration of MCG at a relatively large dose. The LD50 values determined in male and female mice were 26.9 and 28.5 ml/kg, and in male and female rats were 27.4 and 26.7 ml/kg, respectively. In order to evaluate the biological safety of MCG suppository of cefmetazole sodium (CMZ), its local irritation on the mucous membrane was studied. Primary eye irritation of MCG suppository of CMZ was studied in rabbits. Although mild irritation was seen in conjunctivae, no remarkable changes were observed in cornea and iris. Furthermore, primary effect of MCG suppository of CMZ on the rectal mucous membrane was studied macro- and microscopically. It was observed that remarkable histological changes of rectal mucous membrane by MCG suppository of CMZ were not observed in all animals used.
D000818:Animals; D001682:Biological Availability; D001835:Body Weight / Q000187:drug effects; D015311:Cefmetazole; D002513:Cephamycins / Q000008:administration & dosage; D004285:Dogs; D005123:Eye / Q000187:drug effects; D005260:Female; D005989:Glycerides / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007509:Irritants; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012007:Rectum / Q000187:drug effects / Q000473:pathology; D013488:Suppositories; D013997:Time Factors
D002513:Cephamycins; D005989:Glycerides; D007509:Irritants; D013488:Suppositories; D015311:Cefmetazole