Positron emission tomography in the newborn: effect of seizure on regional cerebral blood flow in an asphyxiated infant.
Regional cerebral blood flow (CBF) was measured by positron emission tomography (PET) with 15O-labeled water in an asphyxiated infant during a seizure. After intrauterine asphyxia, the infant had a syndrome characteristic of hypoxic-ischemic encephalopathy. During a PET scan on the second postnatal day, the infant had a focal seizure with deviation of eyes to the right and clonic jerking of the right arm. Regional blood flow was highest, about 80 ml/100 g/min, in the left temporal-parietal frontal region of the left hemisphere, the site of origin of the seizure; blood flow in the same region on the other side was about 57 ml/100 g/min. These observations extend to the newborn previous demonstrations in older patients of a focal increase of CBF at the cerebral site of origin of a focal seizure.
D001238:Asphyxia Neonatorum / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D006801:Humans; D007231:Infant, Newborn; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D014055:Tomography, Emission-Computed