Human semen prostaglandins do not affect sperm motility and migration.
Prostaglandin (PG) E2, PGF2 alpha and testosterone (T) concentrations were determined in the seminal plasma of 57 fertility-clinic patients. Results (mean less than SE) were: PGE2, 3.44 +/- 0.38 mu/ml; PGF2 alpha, 138 +/- 0.33 micrograms/ml; T, 429.54 +/- 14.01 pg/ml. The material was divided into 4 groups: normospermic, oligozoospermic, asthenozoospermic and azoospermic. No statistically significant differences were found among the values of the different groups, except for PGE2, which was found to be increased in the asthenozoospermic group. Sperm migration patterns were assessed in each semen sample, using the Kremer capillary tube test and human cervical mucus. Considering each semen sample individually, no correlations whatever were found among sperm count, motility and migration parameters and the respective concentrations of both PGs and T, nor was there a correlation among PGE2, PGF2 alpha, and T values of the same sample.
D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism; D008297:Male; D009845:Oligospermia / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D013081:Sperm Motility; D013084:Sperm-Ovum Interactions; D013739:Testosterone / Q000378:metabolism
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D013739:Testosterone; D015237:Dinoprost; D015232:Dinoprostone