Ethanol-induced genotoxicity.
Unrelated, nondenatured, ethanol preparations, derived synthetically or by fermentation, were found to induce qualitatively similar concentration-dependent toxic and genotoxic effects as measured by RK mutatest. In this system ethanol was found genotoxic above a threshold concentration of 18-19% (v/v) when RK+ selector cells were transiently exposed for 10 min before selection for RK- survivors at 42 degrees C.
D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*
D000431:Ethanol