[Immunosuppressive properties of olivomycin].
The effect of olivomycin on the cell and humoral immune response was studied on mice. It was shown that antibody genesis stimulated by sheep red blood cells or E. coli lipopolysaccharide was almost equally inhibited by olivomycin when administered 24 hours before administration of the antigen. The magnitude of the delayed type hypersensitivity induced by the antigen low doses (10(5) cells) did not change when the antibiotic was administered in a dose of 1.5 mg/kg. When the antibiotic dose was 3 mg/kg, it decreased 2 times as compared to the control. On immunization of the mice with sheep red blood cells in a dose of 10(9) cells olivomycin administered in the doses inhibiting the antibody genesis induced an increase in the delayed type hypersensitivity. Such an effect of the antibiotic has much in common with the effect of other cytostatics.
D000818:Animals; D000917:Antibody Formation; D000955:Antigens, T-Independent / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli; D007111:Immunity, Cellular; D007114:Immunization; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009848:Olivomycins / Q000276:immunology*; D012756:Sheep
D000955:Antigens, T-Independent; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D009848:Olivomycins
Issledovanie immunodepressivnykh svoistv olivomitsina.