Chromosome replication in early Xenopus embryos.
Early embryos of X. laevis achieve exceptional rates of DNA replication and chromatin assembly. These processes have been studied by microinjecting DNA templates into eggs or by incubating DNA in egg extracts. The egg is able to regulate replication of injected DNA without requiring specialized DNA sequences. Assembly of DNA into the nucleosome subunits of chromatin involves interaction of DNA with complexes containing two classes of acidic protein, namely nucleoplasmin and N1/N2.
D000818:Animals; D001483:Base Sequence; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division; D002875:Chromosomes / Q000648:ultrastructure*; D003513:Cycloheximide / Q000494:pharmacology; D004261:DNA Replication; D004625:Embryo, Nonmammalian / Q000166:cytology*; D005260:Female; D009865:Oocytes / Q000166:cytology; D010957:Plasmids; D014981:Xenopus
D003513:Cycloheximide