Synthesis and anti-inflammatory and analgesic activities of 3-methyl-N-phenyl-1H-pyrazol-5-ylcarboxamides.
The anti-inflammatory and analgesic activities of a series of 3-methyl-N-phenyl-1H-pyrazol-5-ylcarboxamides were investigated and compared with flufenamic acid. The compounds were synthesized by condensation of diketopiperazines 2 with the appropriate aniline. The pharmacological tests showed that some compounds have good anti-inflammatory activity in rat paw edema induced by carrageenin and low toxicity.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000188:drug therapy; D005439:Flufenamic Acid / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles; D005439:Flufenamic Acid