Burn sera mediated effects on the E-rosetting property of normal active T1 cells.
This study investigates the suppressive effects of burn sera on normal active T1 cells. The results revealed that burn sera collected from survivors and non-survivors during the initial 'shock' phase caused varied effects on the 'E' rosetting properties of normal active T1 cells. However, unlike non-survivor sera convalescent or recovery sera failed to block the 'E' rosetting property of T1 cells. Furthermore, cold incubation in fetal calf sera (FCS) failed to abrogate the loss of T1 cells which were exposed to non-survivor (early) sera; these samples also revealed the presence of antigenic factors. Our experiments were extended to investigate the mechanisms resulting in the irreversible change, and showed that the inhibiting factors could be acting at the microtubular level of the cell cortex.
D000818:Animals; D002056:Burns / Q000097:blood* / Q000276:immunology / Q000401:mortality; D002417:Cattle; D002464:Cell Migration Inhibition; D003078:Colchicine / Q000494:pharmacology; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000096:biosynthesis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D003078:Colchicine