title: Neuron-specific enolase-like immunoreactivity in inner hair cells but not outer hair cells in the guinea pig organ of Corti.
abstract: Neuron-specific enolase (NSE) has been localized only in neurons and cells with characteristics of neurons. The immunocytochemical localization of NSE was examined in guinea pig cochleae to determine if hair cells, which have some neuronal characteristics, would show NSE-like immunoreactive labeling. NSE-like immunoreactivity was seen in inner hair cells but not in outer hair cells. This is the first report of NSE-like immunoreactivity in a receptor cell. NSE-like immunoreactivity was also seen in efferent fibers and terminals and in both type I and type II spiral ganglion cells. The finding of NSE-like immunoreactivity in inner but not outer cells adds to the number of differences found between them and may be related to differences in function and action.
mesh_terms: D000818:Animals; D003051:Cochlea / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D005724:Ganglia / Q000166:cytology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000276:immunology*; D006199:Hair Cells, Auditory, Inner / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000145:classification; D009925:Organ of Corti / Q000276:immunology*; D010751:Phosphopyruvate Hydratase / Q000276:immunology*
chemical_list: D010751:Phosphopyruvate Hydratase