title: Ceftazidime plus mezlocillin as initial antibiotic therapy in febrile neutropenic patients with haematological malignancy.
abstract: Sixty episodes of fever in neutropenic patients with haematological malignancy were treated with ceftazidime and mezlocillin. Improvement or temporary improvement was seen in 76% of patients with microbiologically or clinically documented infection. Fifty-seven per cent of episodes due to bacteraemia improved with the antibiotics. Escherichia coli and Staphylococcus aureus were the commonest pathogens isolated; bacteraemia due to Staph. epidermis was not encountered. The toxicity of ceftazidime plus mezlocillin was acceptable. Diarrhoea developed in 12% and a skin rash in 10%.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy; D002177:Candidiasis / Q000209:etiology; D002442:Ceftazidime / Q000008:administration & dosage*; D004338:Drug Combinations; D005334:Fever / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008802:Mezlocillin / Q000008:administration & dosage*; D009369:Neoplasms / Q000150:complications; D009503:Neutropenia / Q000150:complications; D018805:Sepsis / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D004338:Drug Combinations; D002442:Ceftazidime; D008802:Mezlocillin