title: Thiopyronine and 8-methoxypsoralen sensitized photodynamic effect on DNA synthesis in yeast.
abstract: The synthesis of DNA in growing yeast cells was investigated after photodynamic treatment of the cells with thiopyronine (TP) and visible light or with 8-methoxypsoralen (8-MOP) and UVA light. DNA synthesis was inhibited after photodynamic treatment with 8-MOP but not after photodynamic treatment with TP. This result is further evidence that the photodynamic effect with TP does not attack nuclear DNA in eucaryotic cells.
mesh_terms: D004271:DNA, Fungal / Q000096:biosynthesis*; D008730:Methoxsalen / Q000494:pharmacology*; D010777:Photochemistry; D011754:Pyronine / Q000031:analogs & derivatives / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D014966:Xanthenes / Q000494:pharmacology*
chemical_list: D004271:DNA, Fungal; D014966:Xanthenes; C005792:thiopyronine; D008730:Methoxsalen; D011754:Pyronine