title: The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes.
abstract: The T cell surface glycoproteins T4 and T8 are thought to mediate efficient cell-cell interactions in the immune system and in this way may be responsible for the appropriate targeting of subpopulations of T cells. We have used gene transfer combined with subtractive hybridization to isolate both cDNA and functional genomic clones encoding the T8 protein. The sequence of the cDNA reveals that T8 is a transmembrane protein with an N-terminal domain which shares significant homology to immunoglobulin variable region light chains. This immunoglobulin-like structure is likely to be important in the function of T8 during differentiation and in the course of the immune response.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000032:analysis; D001483:Base Sequence; D004247:DNA / Q000302:isolation & purification; D005796:Genes; D006023:Glycoproteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007739:L Cells / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D009693:Nucleic Acid Hybridization; D013601:T-Lymphocytes / Q000276:immunology*; D014170:Transformation, Genetic
chemical_list: D000941:Antigens; D006023:Glycoproteins; D004247:DNA