[Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention].
In a prospective randomized trial clinical results of one-shot-prophylaxis with Tinidazole (Group I, n = 50) versus 9 doses of Metronidazole (Group II, n = 50) as perioperative short-time-prophylaxis were compared. The rate of postoperative wound infections was not significantly different in the groups (p = 0,09). (1/50 in Group I = 2%, 5/50 in Group II = 10%). Postoperative complications clearly occurred less frequently in the first group than in the second one (12% versus 34%, p0,01). Our investigation indicates that prophylactic treatment with Tinidazole as a preoperative high and single dose is important for preventing postoperative infection in patients undergoing bowel surgery.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003108:Colonic Diseases / Q000601:surgery*; D003110:Colonic Neoplasms / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011292:Premedication; D012002:Rectal Diseases / Q000601:surgery*; D012004:Rectal Neoplasms / Q000601:surgery; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014011:Tinidazole / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole
Perioperative Antibiotikaprophylaxe in der Kolon- und Rektumchirurgie. Eine randomisierte Studie zum Wert der 'single-dose' Prophylaxe.