title: Retinol transport proteins and concentrations in human amniotic fluid, placenta, and fetal and maternal sera.
abstract: 1. The proteins binding retinol, and retinol concentrations, were determined in amniotic fluid, placental cytosol and in the fetal and maternal circulation. 2. In non-pregnant women, plasma retinol was almost exclusively found in a transthyretin-retinol-binding-protein complex whereas, in pregnant women, retinol-binding-protein-bound retinol was observed not complexed to transthyretin. This latter fraction increased in concentration with fetal age. These two fractions were the major retinol-protein complexes in amniotic fluid and their relative amounts changed with progress of gestation. 3. In fetal blood both of these fractions were again found, with higher proportions of retinol-binding-protein-bound retinol in the umbilical artery than in the umbilical vein.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D008861:Microsomes / Q000378:metabolism; D008970:Molecular Weight; D010920:Placenta / Q000378:metabolism*; D011228:Prealbumin / Q000378:metabolism; D011247:Pregnancy; D012177:Retinol-Binding Proteins / Q000378:metabolism*; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A / Q000378:metabolism
chemical_list: D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A