title: Intercellular network in articular cartilage of pigs with experimentally induced arthritis. I. Fact or artifact?
abstract: Porcine articular cartilage from cases of experimentally induced Erysipelas arthritis was examined with different histological techniques and by electron microscopy. A small percentage of specimens of osteoarthritic cartilage revealed an interlacunar network in the extracellular matrix. These "matrix-streaks" showed characteristic features of densely packed fibrillar elements and collagenous fibrils, as narrow bands connecting adjacent chondrocytes. In a given cartilage site the network had a constant pattern. It is hypothesized that the network formation is correlated with altered joint metabolism and represents regressive changes in cartilage matrix as a result of external mechanical forces. Using a variety of methods, the possibility of the network being an artifact of histological processing could virtually be ruled out. As there are so far only few and contradictory reports on the interlacunar network of articular cartilage, its precise biological significance remains to be established.
mesh_terms: D000818:Animals; D001170:Arthritis, Infectious / Q000473:pathology*; D002358:Cartilage, Articular / Q000648:ultrastructure*; D004889:Erysipelothrix Infections / Q000473:pathology; D005109:Extracellular Matrix / Q000648:ultrastructure*; D013552:Swine