Effect of intravenous and intraduodenal administration of Escherichia coli endotoxin on the porcine pancreas as evaluated by changes in the serum cationic trypsin-like immunoreactivity.
In six pigs intravenous administration of Escherichia coli endotoxin caused septic shock and a significant increase in serum cationic trypsin-like immunoreactivity (CTLI), with activation of cationic trypsinogen to trypsin and formation of complexes between cationic trypsin, on the one hand, and alpha 2-macroglobulin and alpha 1-antitrypsin, on the other, compatible with acute pancreatitis. In contrast, intraduodenal infusion of E. coli endotoxin to seven other pigs was without effect on the general circulation and on the serum CTLI.
D000818:Animals; D002412:Cations; D004386:Duodenum; D004731:Endotoxins / Q000008:administration & dosage*; D004926:Escherichia coli; D005260:Female; D007263:Infusions, Parenteral; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D011863:Radioimmunoassay; D013552:Swine; D014357:Trypsin / Q000097:blood*
D002412:Cations; D004731:Endotoxins; D014357:Trypsin