Differences in the inhibitory effects of N-(1-n-dodecyl)-heterocycles on the 2,3-oxidosqualene lanosterol-cyclase of rat liver and yeast.
The ability of thirteen N-(1-n-dodecyl)-heterocyclic compounds and one N-(1-n-fluoroalkyl)-heterocyclic compound to inhibit the 2,3-oxidosqualene lanosterol-cyclase of rat liver and yeast has been tested. Eight of the N-(1-n-dodecyl)-heterocycles inhibited the rat liver enzyme well but none inhibited the yeast enzyme at 100 microM concentrations. The N-(1-fluoroalkyl)-heterocycle inhibited the rat liver enzyme mildly but did not inhibit the yeast enzyme at 100 microM concentration. It is evident that the rat liver and yeast cyclases are different; the possible nature of these differences is discussed.
D000818:Animals; D002855:Chromatography, Thin Layer; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D019751:Intramolecular Transferases; D007535:Isomerases / Q000037:antagonists & inhibitors*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology*
D006571:Heterocyclic Compounds; D007535:Isomerases; D019751:Intramolecular Transferases; C021924:lanosterol synthase