Isolated malignant lymphoma of the jejunum and long-term diphenylhydantoin therapy.
We report a case of isolated malignant lymphoma of the jejunum occurring 18 18 months after continuous diphenylhydantoin therapy for epilepsy. Although this association may be purely coincidental, we suggest a possible causal relationship between the two in light of current knowledge about the immunological aberrations that may be caused by prolonged administration of diphenylhydantoin in man.
D000368:Aged; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D007580:Jejunal Neoplasms / Q000139:chemically induced*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000139:chemically induced*; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D010672:Phenytoin