Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens.
Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelinated fiber damage.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002645:Chickens; D002800:Cholinesterase Inhibitors; D003345:Corticosterone / Q000494:pharmacology*; D007531:Isoflurophate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D009410:Nerve Degeneration / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D009474:Neurons / Q000201:enzymology; D010587:Phagocytosis / Q000187:drug effects
D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase; D003345:Corticosterone