Response of the lymph node to tumour antigen and Bacillus Calmette-Guerin in cattle bearing tumours of the ethmoturbinate region.
The immunological response of the Ln subiliacus (externus) in cattle bearing ethmoid carcinoma was studied. The lymph node was stimulated in vivo by I/D administration of tumour antigen and Bacillus Calmette-Guerin and the changes in the lymph node were studied at 3-day intervals up to 15 days. The histological changes in the lymph node were assessed and the functional activity of the activated macrophages in the lymph node impression smears was evaluated using Nitroblue tetrazolium salt reduction test. Similar studies were also undertaken in age-matched healthy nontumour bearing cattle. On stimulation with BCG and tumour antigen there was stimulation of the T cell dependent area. However, the response to the tumour antigen was quicker but shorter in duration compared with that to BCG. The response in healthy animals was proportionately much less. The studies indicated that tumour-bearing animals which were mostly in stage II were immunocompetent.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000473:pathology; D005005:Ethmoid Sinus; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D009163:Mycobacterium bovis / Q000276:immunology; D010255:Paranasal Sinus Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D013997:Time Factors
D000951:Antigens, Neoplasm