Peanut agglutinin, a marker for T-cell acute lymphoblastic leukemia with a good prognosis.
Peanut agglutinin (PNA) binding was studied in cells from 74 children with acute lymphoblastic leukemia (ALL). PNA positivity occurred in 50% of T-ALL (12 of 24) and was rare in other types of ALL. There was no clear relationship between PNA and initial white blood cell count, French-American-British classification, stage of differentiation of leukemic cells, hand mirror cells, and organomegaly at diagnosis. Prognosis, however, was significantly better (continuous complete remission, death) in the PNA-positive T-ALLs. It seems that PNA is a useful marker for a subgroup of T-ALL with a better prognosis.
D006801:Humans; D037102:Lectins; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000188:drug therapy; D019887:Peanut Agglutinin; D010641:Phenotype; D011379:Prognosis; D013601:T-Lymphocytes
D037102:Lectins; D019887:Peanut Agglutinin