The dopamine autoreceptor agonist B-HT 920 markedly stimulates sexual behavior in male rats.
B-HT 920, a selective agonist at dopamine (DA) autoreceptors, strongly increased the incidence of penile erections (PE) in male rats, an effect which was dose-related and antagonized by haloperidol. B-HT 920 at 100 and 200 micrograms/kg i.p. significantly altered the copulatory pattern of sexually active male rats, reducing the number of mounts and intromissions as well as the latency to the first ejaculation, a stimulant effect which was confirmed in sluggish males at a dose of 100 micrograms/kg.
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D003307:Copulation / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D001381:Azepines; D011954:Receptors, Dopamine; C024763:talipexole; D006220:Haloperidol