Horse leucocyte proteinase-inhibitor system. Kinetic parameters of the inhibition reaction.
Horse leucocyte neutral proteinase inhibitor reacts with all tested elastases at the molar ratios of 1:1 and yielding stable complexes (Ki = 10(-10) M). The above reactions are very rapid, characterized by the high values of association rate constant kon = 10(7) M-1s-1.
D000818:Animals; D010450:Endopeptidases / Q000097:blood; D006736:Horses / Q000097:blood*; D007700:Kinetics; D007962:Leukocytes / Q000032:analysis*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011480:Protease Inhibitors / Q000097:blood / Q000494:pharmacology*
D011480:Protease Inhibitors; D010450:Endopeptidases; D010196:Pancreatic Elastase