title: Invasive potential of superficial bladder cancer. A study of the relative merits of predictive parameters.
abstract: The indirect immunoperoxidase test to detect urothelial cell surface blood group antigens was performed in an attempt to assess the loss of these antigens as a prognostic predictor. In our technique A, B and O(H) blood group specific monoclonal antibodies were used. It was possible to perform the test satisfactorily on histological material from 55 cases which were superficial on presentation; 15 subsequently became invasive. The loss of surface antigens correlated well with histological grade--44.4% of G1, 87.2% of G2 and 94.1% of G3 tumours were antigen-negative. The blood group phenotype of 114 patients was studied. In the group that subsequently became invasive, 14 of 26 (54%) were of blood group A phenotype compared with 37 of 88 (42%) in the non-invasive category. Acetylation studies were performed on 47 cases. In the group that subsequently became invasive, 5 of 10 (50%) had the slow phenotype of the enzyme N-acetyltransferase compared with 13 of 37 (35%) in the group that remained superficial.
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D001789:Blood Group Antigens / Q000276:immunology; D002295:Carcinoma, Transitional Cell / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007519:Isoantigens / Q000032:analysis; D009361:Neoplasm Invasiveness; D010641:Phenotype; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001789:Blood Group Antigens; D007519:Isoantigens; D000123:Acetyltransferases