title: [Metabolic state of liver mitochondria and lymphocytes after T-activin administration under condition of hypothermia].
abstract: After 10 days of swimming (10 min per day, water temperature +20 degrees C) the oxygen consumption in rat liver mitochondria increased via the external pathway of NADH oxidation from 3.6 +/- 0.3 to 4.4 +/- 0,2 nmoles O2 x min-1 x mg-1 protein; when the rats were simultaneously injected with an endogenous immunomodulator T-activin (5 micrograms/100 g body weight) daily, this rate increased up to 6.5 +/- 0.6 nmoles O2 x min-1 x mg-1 protein. In the control group, the uncoupled respiration rate is also higher, while the ascorbate+ +TMPD oxidation rate is lower than in the cold- and cold + T-activin-treated groups. The metabolic states of lymphocyte mitochondria did not differ in the three experimental groups. The respiration rates and delta psi m (monitored by diS-C3-(5) fluorescence) of lymphocyte mitochondria in these three groups were also identical.
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D007035:Hypothermia / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D009929:Organ Size; D010101:Oxygen Consumption; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013050:Spectrometry, Fluorescence; D013601:T-Lymphocytes / Q000378:metabolism*; D013949:Thymus Extracts / Q000494:pharmacology*
chemical_list: D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
vernacular_title: Metabolicheskoe sostoianie mitokhondriĭ pecheni i limfotsitov pri vvedenii T-aktivina na fone rezkikh okhlazhdeniĭ.