title: Relationship of HLA-DR4 to defective cellular immunity in rheumatoid arthritis using PPD, and mycoplasma and lectin mitogens.
abstract: The disordered cellular immunity of rheumatoid arthritis (RA) was studied in vitro by assessing the stimulatory effect of tuberculin PPD, a mycoplasma product with major histocompatility complex restricted properties in mice (MAS) and concanavalin A (Con A) on RA and control cells of known tissue type. PPD provided the best discrimination between RA and controls (RA responses 34% of latter). The only significant association with HLA-DR type was that patients with RA who exhibited poor responsiveness to MAS had a significantly increased frequency of HLA-DR4.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009174:Mycoplasma / Q000276:immunology; D014373:Tuberculin / Q000276:immunology
chemical_list: D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D014373:Tuberculin; D003208:Concanavalin A