[Venous occlusive disease of the liver and autologous bone marrow transplantation. Preventive role for heparin?].
The pathogenesis of veno-occlusive disease (VOD) of the liver remains unclear. In a retrospective study we reviewed 63 patients treated with high dose conditioning regimens followed by autologous bone marrow transplant. All patients were given low dose heparin (1 mg/kg). Only one patient developed VOD when heparin was stopped. We think that low dose heparin seems an interesting proposal for an randomized study to prevent VOD.
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D016026:Bone Marrow Transplantation; D006502:Budd-Chiari Syndrome / Q000209:etiology / Q000517:prevention & control*; D006086:Graft vs Host Disease / Q000150:complications; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents; D006493:Heparin
Maladie veino-occlusive du foie et autogreffe de moelle osseuse. Rôle préventif de l'héparine?