title: [Effects of changes in K+ in the perilymphatic fluid on the activity of vestibular receptors in the frog].
abstract: The effect of rapid changes in K+ concentration (from 0 up to 5 mM) in the perilymphatic fluid was tested on ampullar receptor activity in isolated semicircular canals of the frog. The effects of the different K-concentrations were evaluated by recording both the transepithelium potentials (Adc) and the postsynaptic potentials (EPSPs and spikes discharge) led off from the ampullar nerve. The results have clearly demonstrated that crista ampullaris sensory cells are extremely sensitive to K-changes (+/- 0.25 mM). In fact both transepithelial potentials and discharge activity (EPSPs and propagated spikes) of first order vestibular neurones may be decreased or increased by decreasing or increasing the K-concentration in the outer fluid. The possible mechanism of action of K+ on ampullar receptors is discussed.
mesh_terms: D000818:Animals; D004594:Electrophysiology; D004848:Epithelium / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology*; D011893:Rana esculenta; D012665:Semicircular Canals / Q000187:drug effects*; D013569:Synapses / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000502:physiology*
chemical_list: D011188:Potassium
vernacular_title: Effetti delle variazioni di K+ nel liquido perilinfatico sulla attivita' dei recettori vestibolari della rana.