Increased incidence of Ia antigen-bearing T lymphocytes in the spontaneously diabetic BB rat.
The frequency of Ia-positive T lymphocytes in spontaneously diabetic BB rats was assessed by using monoclonal antibodies and a fluorescence-activated cell sorter. These cells peaked in frequency during the early stages of hyperglycemia, with a gradual decline toward normal as the disease progressed. Significantly increased numbers of Ia-positive T cells were detected in both helper (W3/25+) and cytotoxic-suppressor (OX8+) subsets. The elevated levels of Ia-positive T lymphocytes in these rats may be relevant to the immune destruction of their beta cells.
D000208:Acute Disease; D000818:Animals; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics / Q000276:immunology*; D011920:Rats, Inbred WF; D013601:T-Lymphocytes / Q000145:classification*; D013897:Thoracic Duct / Q000166:cytology
D000949:Histocompatibility Antigens Class II