Plaque inhibition by sustained release of chlorhexidine from removable appliances.
We studied the effectiveness of a sustained-release delivery system for chlorhexidine in plaque prevention. A clinical trial in a group of eight students wearing orthodontic appliances coated by ethyl cellulose polymer containing the drug demonstrated that plaque accumulation was decreased for a period of four days. All oral procedures had been withdrawn during the clinical study. No side-effects of chlorhexidine, such as tooth staining and unpleasant taste, were observed.
D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives; D002710:Chlorhexidine / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000517:prevention & control*; D004058:Diffusion; D006801:Humans; D009968:Orthodontic Appliances, Removable; D011108:Polymers
D003692:Delayed-Action Preparations; D011108:Polymers; C013517:ethyl cellulose; D002482:Cellulose; D002710:Chlorhexidine