Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice.
The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice. GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The administration of GF-1 into mice increased the weights or cell numbers of spleen, and peritoneal cavity. GF-1 enhanced the antigen specific antibody response and carbon clearance activity, whereas GF-1 did not show polyclonal B cell activation and mitogenic activities, and the effect on delayed type hypersensitivity.
D000818:Animals; D000917:Antibody Formation; D000946:Antigens, Fungal / Q000276:immunology*; D001487:Basidiomycota / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects; D011124:Polyporaceae / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
D000946:Antigens, Fungal; D011134:Polysaccharides