title: Immunology and immunogenetics in metabolic diseases.
abstract: The first part of the work reviews some general data regarding the HLA system and emphasizes the principal implications of this system in diabetes mellitus and other metabolic diseases. Part two discusses pathoimmunological mechanisms in metabolic pathology (on the one hand those linked to autoimmunity, on the other those linked to immunologic deficiency of enzymatic origin). Finally, some immunologic aspects in the treatment of metabolic diseases are outlined.
mesh_terms: D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000276:immunology; D002874:Chromosome Mapping; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology; D004198:Disease Susceptibility; D006680:HLA Antigens / Q000235:genetics*; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D007111:Immunity, Cellular; D008285:Major Histocompatibility Complex; D008659:Metabolic Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D009765:Obesity / Q000235:genetics; D011164:Porphyrias / Q000235:genetics; D011687:Purines / Q000378:metabolism; D012871:Skin Diseases / Q000235:genetics
chemical_list: D006680:HLA Antigens; D011687:Purines