Heterogeneity of dermal OKT6+ cells in inflammatory and neoplastic skin diseases.
This immunopathologic study of both normal and pathologic skin specimens (contact dermatitis [CD], lichen planus [LP], cutaneous T cells lymphoma [CTCL], and histiocytosis X [HX]) allowed as to differentiate four types of dermal OKT6+ cells: (1) cells with the same morphologic features as epidermal Langerhans cells (LCs), rarely found in either normal or pathologic dermis; (2) cells structurally similar to LCs but lacking Birbeck granules (BGs), found mainly in CD and LP; (3) larger cells rich in cytoplasmic organelles, only 5% of which contained BGs. They were especially common CTCL; and (4) cells typical of HX.
D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D003877:Dermatitis, Contact / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology; D006801:Humans; D007801:Langerhans Cells / Q000473:pathology*; D008010:Lichen Planus / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D012751:Sezary Syndrome / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal