Assessment and modification of pain on induction with propofol (Diprivan).
Assessment of pain on injection of the emulsified formulation of di-isopropylphenol (propofol, 'Diprivan') was undertaken in 120 unpremedicated patients and comparison made with thiopentone. A high incidence of pain (37.5%) was found using dorsal hand veins, but use of forearm veins showed only a 2.5% incidence of pain. The use of intravenous lignocaine immediately before propofol injection only partially reduced the incidence of pain using dorsal hand veins (17.5%). A degree of cardiorespiratory depression accompanied induction but the incidence of other side effects was low.
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D001049:Apnea / Q000139:chemically induced; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology* / Q000517:prevention & control; D010636:Phenols / Q000009:adverse effects*; D011292:Premedication; D015742:Propofol; D013997:Time Factors
D000777:Anesthetics; D010636:Phenols; D008012:Lidocaine; D015742:Propofol