[Treatment of hypertension in the diabetic with captopril].
The apparently excellent pharmacological properties of Captopril as treatment for insulin-dependent and other hypertensive diabetics of all ages were investigated at a Diabetes Centre. Fifteen out-patients receiving oral hypoglycaemic drugs or insulin and suffering from slight or moderate hypertension (diastolic AP: 95-115 mmHg) were selected for treatment. The Captopril was administered in daily doses of 50 or 100 mg for 60 days. Tests on the 30th and 60th days revealed a statistically significant reduction in max/min OAP values, but no statistically significant variations in either cardiac frequency or glycaemia before and after meals. Nor did the main haematochemical parameters show any significant alteration.
D000368:Aged; D002216:Captopril / Q000627:therapeutic use*; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*
D011392:Proline; D002216:Captopril
Trattamento dell'ipertensione nel diabetico con captopril.