title: Clinical and physiological basis for a new method underlying rehabilitation of the damaged visual nerve function by direct electric stimulation.
abstract: A new method of rehabilitation of damaged visual nerves has been tested during clinical physiological investigations in 45 patients with pathological opticochiasmal brain tumor, inflammation and trauma. The essence of the new method was in implanting the electrode into the nerve when the patient was operated on for the pathological formation and in directly stimulating the nerves for 2 or 3 postoperational weeks. Effectiveness of electrical stimulation was increased by direct recording of the electroneurogram as well as by the results of ophthalmological observations. Considerable improvement of vision was observed in 75%, and in 25% of these cases the vision was found to actually normalize. Even in cases of total blindness, vision was partially rehabilitated in 8 of 10 cases. Direct electrophysiological investigation of the visual nerve potentials enabled us to objectively estimate their functional state, predict the probability of visual rehabilitation as well as increase the efficiency of therapy. Neurophysiological mechanisms of visual rehabilitation under the influence of electrical stimulation of the visual nerves are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D004599:Electric Stimulation Therapy / Q000379:methods*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000503:physiopathology / Q000628:therapy*; D009901:Optic Nerve Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D014786:Vision Disorders / Q000209:etiology / Q000628:therapy*; D014795:Visual Pathways / Q000503:physiopathology