title: Pharmacokinetic scale-up: accurate prediction of human pharmacokinetic profiles from animal data.
abstract: Ceftizoxime pharmacokinetic parameters from mice, rats, monkeys, and dogs were scaled allometrically and used to predict the value of each parameter in a 70-kg human. Three methods of interspecies pharmacokinetic scale-up provided accurate simulations of the human biexponential serum concentration-time profiles for a 1-g iv bolus and a 4-g, 30-min intravenous infusion. Successful scale-up of animal pharmacokinetic data can have tremendous impact during the preclinical assessment of new pharmaceutical compounds by providing reasonable estimates of pharmacokinetic parameters in humans.
mesh_terms: D000818:Animals; D002439:Cefotaxime / Q000031:analogs & derivatives / Q000378:metabolism; D015296:Ceftizoxime; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D004364:Pharmaceutical Preparations; D015296:Ceftizoxime; D002439:Cefotaxime