Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection.
H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.
D000818:Animals; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D007109:Immunity; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection
D006183:H-2 Antigens