Ro (SS-A) antibody and antigen in a patient with congenital complete heart block.
Congenital complete heart block is closely associated with the presence of anti-Ro (SS-A) autoantibodies. Quantitative solid-phase assays for Ro (SS-A) autoantigen and autoantibody have established the presence of Ro (SS-A) in cardiac tissues and have been used to evaluate an informative pedigree. The propositus we describe here had complete congenital heart block and showed anti-Ro (SS-A) binding of 13-fold less than his normal HLA-identical twin sister. Both had identical titers of antinuclear antibody. These data support the hypothesis that anti-Ro (SS-A) may be directly involved in the pathogenesis of congenital complete heart block.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D000941:Antigens / Q000032:analysis*; D001324:Autoantigens / Q000032:analysis*; D004200:Diseases in Twins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005333:Fetus / Q000276:immunology; D006327:Heart Block / Q000150:complications / Q000151:congenital* / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009206:Myocardium / Q000276:immunology; D010375:Pedigree; D011233:Precipitin Tests; D011247:Pregnancy; D011296:Prenatal Diagnosis; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D000941:Antigens; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human