Hydroxylation and conjugation of phenol by the frog Rana temporaria.
Frogs injected with phenol excrete 67-95% of dose in 15 h; 32-87% of dose are metabolites. Metabolites identified were phenyl sulphate (15-44% of dose), phenyl glucuronide (10-25% of dose), catechol sulphate (up to 7% of dose), quinol sulphate (1-25% of dose), resorcinol and catechol (traces).
D000818:Animals; D002250:Carbon Radioisotopes; D002396:Catechols / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005965:Glucuronates / Q000032:analysis; D006873:Hydroquinones / Q000032:analysis; D006900:Hydroxylation; D019800:Phenol; D010636:Phenols / Q000378:metabolism*; D011896:Rana temporaria; D012118:Resorcinols / Q000032:analysis; D013463:Sulfuric Acid Esters / Q000032:analysis
D002250:Carbon Radioisotopes; D002396:Catechols; D005965:Glucuronates; D006873:Hydroquinones; D010636:Phenols; D012118:Resorcinols; D013463:Sulfuric Acid Esters; C025298:phenylglucuronide; D019800:Phenol; C025208:phenylsulfate; C034221:catechol; C038506:quinol sulfate; C031389:resorcinol