title: Compound effects of bisulphite ion on frog skeletal muscle.
abstract: To characterize the structures of the nicotinic cholinoceptors in the frog rectus abdominis muscle, group-selective reagents have been used. Possible modifications of the excitation-contraction coupling have also been studied. The effect of the bisulphite ion on skeletal muscle has been demonstrated earlier at presynaptic and postsynaptic levels. Another report questioned whether these effects were significant to the contractile process in general. The present study shows that bisulphite induced qualitative and quantitative changes in the muscular response to acetylcholine and electrical stimulation. The intervention is likely at the level of excitation-contraction coupling as well as at the previously proposed sites.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D005703:Gallamine Triethiodide / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000502:physiology; D011894:Rana pipiens; D013447:Sulfites / Q000494:pharmacology*
chemical_list: D013447:Sulfites; D000109:Acetylcholine; D005703:Gallamine Triethiodide; C009279:sodium bisulfite