Necrotizing granulomatous splenitis complicating leukemia in childhood.
Two children are described with acute leukemia in remission who both developed a swinging pyrexia and pathologically identical splenic necrotizing granulomata. No organisms were seen in, or isolated from, either spleen. After splenectomy, systemic symptoms persisted and did not resolve until steroids were given. The etiology of this syndrome remains unknown.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D005260:Female; D005334:Fever / Q000150:complications; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced; D018805:Sepsis / Q000150:complications; D013156:Splenectomy; D013158:Splenic Diseases / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014463:Ultrasonography