Suppression of recurrent genital herpes with oral acyclovir.
Peroral acyclovir has been used as long-term prophylactic treatment for frequent recurrences of genital herpes in four clinical studies comprising 172 patients. At a daily dose of 600 to 1 000 mg it seems to be effective in preventing recurrences in a majority of patients. The treatment does not prevent recurrences after the medication is stopped. The treatment seems to be safe for periods up to 4 months. At present it should be used only in carefully selected cases with seriously debilitating symptoms to prevent recurrences during a short period.
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D004311:Double-Blind Method; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012008:Recurrence
D000212:Acyclovir