title: Protocol for X-ray dosimetry and exposure arrangements employed in studies of late somatic effects in mammals.
abstract: A number of European laboratories studying the late effects of ionizing radiation in animals have established an effective cooperation within the European Late Effects Project Group (EULEP) since 1970. To facilitate the exchange of biological results several techniques, including quality control of the experimental animals, pathology and dosimetry, have to be standardized. The most important aspects of the procedures for X-irradiation and dosimetry of small animals are summarized. These include recommendations on irradiation conditions, dosimetry methods, characteristics of phantoms and factors affecting X-ray dosimetry. X-irradiation procedures employed by the participating institutes are described and the results of five X-ray dosimetry intercomparisons are reported. The introduction of a common dosimetry protocol has resulted in improvements in exposure arrangements and absolute dosimetry.
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D051379:Mice; D008961:Models, Structural; D011829:Radiation Dosage; D011853:Radiobiology / Q000592:standards*; D011874:Radiometry / Q000592:standards*; D051381:Rats; D013997:Time Factors; D014916:Whole-Body Irradiation / Q000379:methods