Activities of a soluble extract from lymphoid cells of MRL mice. Effect on B cell differentiation in vitro.
Soluble extract (sEx) was prepared from lymphoid cells of MRL/Mp-lpr/lpr(MRL/l) mice with early lupus nephritis and also of MRL/Mp-+/+ (MRL/n) mice. sEx from lymph node and spleen T cells of MRL/l mice had an activity for B cells to differentiate into immunoglobulin-producing cells but that of MRL/n mice did not show such an activity. sEx of MRL/l mice also enhanced the in vitro response of B cells to a suboptimal dose of lipopolysaccharide. Implication of these phenomena in the development of lupus nephritis is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009393:Nephritis / Q000209:etiology / Q000276:immunology; D013154:Spleen / Q000166:cytology; D014020:Tissue Extracts
D014020:Tissue Extracts