HLA antigens in ovarian adenocarcinoma patients.
Sixty five patients affected by ovarian carcinoma, 40 controls with benign ovarian disease were typed for HLA A, B and C antigens and compared with 132 adult female blood donors. A highly significant increase in HLA B7 antigen (p = 0,0083) and a decrease in HLA A11, A28, B12 (p = 0,04; p = 0.03 respectively) in patients vs controls has been noticed. The comparison among the ovarian benign disease patients, and those with ovarian carcinoma and the healthy controls showed a decrease in the HLA A1 antigen frequency. Besides, the patients presented an increased and a decreased frequency of the A and O blood phenotypes respectively. These data confirm those of other Authors, and we can conclude that the neoplastic disease does not show a strong association with histocompatibility antigens.
D000017:ABO Blood-Group System; D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; D015235:HLA-B Antigens; D015793:HLA-B7 Antigen; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000276:immunology*
D000017:ABO Blood-Group System; D006680:HLA Antigens; D015234:HLA-A Antigens; D059870:HLA-A11 Antigen; C037164:HLA-A28 antigen; D015235:HLA-B Antigens; C035015:HLA-B12 antigen; D015793:HLA-B7 Antigen