Functional properties of isolated hepatocytes from ethanol-treated rat liver.
Gluconeogenesis and palmitate incorporation into triacylglycerols and phosphatidylcholine were measured in isolated hepatocytes from control and ethanol-treated rats. Basal gluconeogenesis and its hormonal response decreased in hepatocytes from ethanol-treated animals; palmitate incorporation into triacylglycerols increased. In ethanol-treated rat liver, 45Ca2+ uptake and methylating capacity were reduced, and the hormonal response exhibited differences in binding parameters of insulin.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005235:Fatty Liver, Alcoholic / Q000473:pathology*; D005934:Glucagon / Q000378:metabolism; D005943:Gluconeogenesis; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008745:Methylation; D010168:Palmitates / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D007328:Insulin; D010168:Palmitates; D010713:Phosphatidylcholines; D010743:Phospholipids; D014280:Triglycerides; D000431:Ethanol; D005934:Glucagon; D002118:Calcium