Combined activity of metronidazole and gentamicin on Bacteroides fragilis in vivo and in vitro.
A mixed aerobic/anaerobic infection in mice was established by co-injecting Bacteroides fragilis and Escherichia coli into a thigh muscle. Metronidazole administration 6 h after this inoculation resulted in a dose-dependent decrease of Bact. fragilis at 18 h after drug administration. Co-administration of gentamicin with metronidazole resulted in a significant decrease of the numbers of E. coli but did not markedly influence the effect of metronidazole on Bact. fragilis.
D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy; D001441:Bacteroides fragilis / Q000187:drug effects*; D004357:Drug Synergism; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice
D005839:Gentamicins; D008795:Metronidazole