title: Incorporation of chorismic acid and 4-aminobenzoic acid into the 4-hydroxyaniline moiety of N-(gamma-L-glutamyl)-4-hydroxyaniline in Agaricus bisporus.
abstract: Agaricus bisporus contains the unique aniline derivative, N-(gamma-L-glutamyl)-4-hydroxyaniline. 14C-labelled chorismic acid was quantitatively incorporated into the 4-hydroxyaniline moiety of this aniline derivative, whereas 14C-labelled prephenic acid and anthranilic acid were not incorporated into 4-hydroxyaniline. These observations indicate the branch point of the biosynthetic route of 4-hydroxyaniline in the shikimic acid pathway to be chorismic acid. Moreover, 4-aminobenzoic acid proved to be an effective precursor of 4-hydroxyaniline.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D000363:Agaricales / Q000378:metabolism*; D062365:Aminobenzoates / Q000378:metabolism*; D000627:Aminophenols / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D002827:Chorismic Acid / Q000378:metabolism*; D002850:Chromatography, Gel; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism*; D005973:Glutamine / Q000031:analogs & derivatives* / Q000096:biosynthesis
chemical_list: D062365:Aminobenzoates; D000627:Aminophenols; D002250:Carbon Radioisotopes; D003509:Cyclohexanecarboxylic Acids; D005973:Glutamine; C001298:gamma-L-glutaminyl-4-hydroxybenzene; D002827:Chorismic Acid; C026729:4-aminophenol; D010129:4-Aminobenzoic Acid