title: Does renal failure induce a decrease in cyclosporine blood concentrations?
abstract: Blood Cys concentrations were monitored twice weekly by RIA in nine patients undergoing renal transplantation. The Cys dose was adapted to obtain blood values between 100-400ng/ml. A negative correlation was found between plasma creatinine and blood Cys, even in those patients in whom the oral dosage was not changed (r = 0.65, n = 23, p less than 0.001). In vitro studies showed no effect of uraemic blood on Cys measurement. It seems probable that uraemia induces changes in distribution volume and/or gastrointestinal absorption of the drug. Careful monitoring of Cys during uraemia is therefore warranted.
mesh_terms: D000328:Adult; D003524:Cyclosporins / Q000009:adverse effects / Q000097:blood*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014511:Uremia / Q000097:blood*
chemical_list: D003524:Cyclosporins