Increased plasma interleukin-1 activity in women after ovulation.
The polypeptide interleukin-1 mediates many host responses to infection and inflammation. A method was developed for studying interleukin-1 levels in human plasma from febrile patients. Interleukin-1 activity was also consistently found in plasma samples from women in the luteal phase of their menstrual cycle. This activity was neutralized by a specific antiserum to human interleukin-1 and was low in plasma from healthy men and preovulatory women. Thus interleukin-1 appears to have a role in normal physiological conditions as well as in disease states.
D000818:Animals; D001831:Body Temperature; D005260:Female; D005334:Fever / Q000503:physiopathology; D005498:Follicular Phase; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis* / Q000502:physiology; D008183:Luteal Phase; D008297:Male; D051379:Mice; D010060:Ovulation
D007375:Interleukin-1