Calcitonin gene-related peptide: brain and spinal action on intestinal motility.
The effects of intracerebroventricular (ICV) and intrathecal (IT) administration of calcitonin gene-related peptide (CGRP) on intestinal motility were examined in conscious rats chronically fitted with intraparietal electrodes in the duodeno-jejunum and a cannula in a cerebral lateral ventricle or catheter in the subarachnoid space. ICV administration of CGRP (0.5-10 micrograms) restores the fasted pattern of intestinal motility in fed rats in a dose-related manner. Intrathecal administration of CGRP or calcitonin also induces fasted pattern but after a 30 min delay. These effects persisted after transection of the spinal cord and no change in intestinal motility appeared after intravenous administration of CGRP at a dose effective when given IT. This study suggests that CGRP, as calcitonin, has a neuromodulatory role in the control of intestinal motility at both brain and spinal cord levels.
D000818:Animals; D001921:Brain / Q000502:physiology*; D002116:Calcitonin / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004386:Duodenum / Q000187:drug effects / Q000502:physiology; D004553:Electric Conductivity / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D007583:Jejunum / Q000187:drug effects / Q000502:physiology; D008297:Male; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D014665:Vasodilator Agents; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide