Receptors for thymosin alpha 1 on mouse thymocytes.
Thymosin alpha 1 is able to act in vitro to stimulate T-cell precursors and to induce surface markers. The initial mechanism by which alpha 1 activates T cells could be the binding of alpha 1 to cell membranes. Using a specific anti-alpha 1 antibody and an indirect immunofluorescence procedure it was found that thymosin alpha 1 binds to the surface of a large portion of murine lymphocytes. Furthermore, thymocytes have been fractionated into immature and mature subpopulations by using the peanut agglutinin (PNA) technique. It was found that PNA+, immature cells showed specific receptors for alpha 1 on the cell membrane.
D000818:Animals; D005455:Fluorescent Antibody Technique; D037102:Lectins; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019887:Peanut Agglutinin; D010641:Phenotype; D011971:Receptors, Immunologic / Q000032:analysis*; D013601:T-Lymphocytes / Q000145:classification / Q000378:metabolism*; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000378:metabolism
D037102:Lectins; D019887:Peanut Agglutinin; D011971:Receptors, Immunologic; C034055:thymosin receptor; D013947:Thymosin; D000077596:Thymalfasin