[Effect of diucifon and its structural precursors on inflammatory and pain reactions].
The anti-inflammatory and analgesic action of diucifon, methyluracil and 4,4'-diaminodiphenylsulfone (DDS) was studied in comparison with some nonsteroid preparations. In three traditional models of agar, kaolin and carrageenan paw edema and in the models of analgesia (convulsions, induced by intraabdominal administration of acetic acid to mice and hyperalgesia according to Randall-Selitto's test in rats), diucifon proved more active than its precursors. In Randall-Selitto's test the efficiency of diucifon was 1.5 times less than that of butadione but 24 times higher than that of methyluracil; DDS had no analgetic activity. Diucifon, methyluracil and DDS did not exert any ulcerogenic action.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use* / Q000633:toxicity; D003622:Dapsone / Q000627:therapeutic use* / Q000633:toxicity; D004338:Drug Combinations / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced; D013450:Sulfones / Q000627:therapeutic use* / Q000633:toxicity; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D013450:Sulfones; C023367:diucifon; D014498:Uracil; C008378:6-methyluracil; D003622:Dapsone
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