Interleukin 1 regulates human metallothionein gene expression.
Incubation of cultured human cells with interleukin 1 leads to increased expression of the human metallothionein-IIA gene. Recently, metallothionein has been shown to be an efficient free radical scavenger, and induction by interleukin 1 may be part of a protective response to minimize damage by hydroxyl radicals.
D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008668:Metallothionein / Q000235:genetics*; D051379:Mice; D013045:Species Specificity
D007375:Interleukin-1; D008668:Metallothionein