Changes of haemostaseological variables in carbon tetrachloride poisoning in rats.
On application of carbon tetrachloride to rats disturbances of haemostasis were observed. Antithrombin III and 4-amidinophenylpyruvic acid were found to exert a beneficial action on these disturbances. However, the thrombin inhibitors had no influence on hepatotoxicity and lethality.
D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology; D001780:Blood Coagulation Tests; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects*; D008107:Liver Diseases / Q000517:prevention & control; D010667:Phenylpyruvic Acids / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000037:antagonists & inhibitors
D010667:Phenylpyruvic Acids; C006492:amidinophenylpyruvic acid; D000990:Antithrombin III; D002251:Carbon Tetrachloride; D013917:Thrombin