Long-term toxicity of a hydrogelic occlusive device in the isthmus of the human oviduct. A light microscopic study.
Ten women applying for sterilization volunteered for a tubal blocking procedure. An occlusive device of gamma polymerized hydrogel, a P-block, was applied in the isthmic part of the oviduct by trans-cervical hysteroscopy. Bilateral expulsion occurred in three and unilateral in six subjects. Six patients became pregnant. The P-block was in position from one week to 32 months. Histologically, the reaction to the P-block was first erosion and acute unspecific inflammation. Later there was a histiocytic and foreign-body reaction due to dissolution of the hydrogel. When the P-block was expelled no changes were present in the material.
D000818:Animals; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010057:Oviducts / Q000187:drug effects* / Q000473:pathology; D011092:Polyethylene Glycols / Q000633:toxicity*; D013246:Sterilization, Tubal / Q000009:adverse effects
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols