Haemolytic anaemia associated with increased cation permeability.
Volume regulation in the red cell depends on the balance between the osmotic swelling pressure contributed by the polyvalent anions 2,3-DPG and haemoglobin, and the counterbalancing osmotic pressure provided by extracellular Na+. Although changes in 2,3-DPG have been identified in some cases, increases in the electrodiffusional leak of Na+ and K+ are most likely responsible for the disorders of volume regulation leading to haemolytic anaemia. The current challenge is to identify the membrane proteins and/or lipids which play a key role in passive transport of the monovalent cations.
D000743:Anemia, Hemolytic / Q000378:metabolism* / Q000503:physiopathology; D002463:Cell Membrane Permeability; D002499:Centrifugation, Density Gradient; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D009994:Osmolar Concentration