title: Intestinal pathology in the dog induced by sublethal doses of amiodarone.
abstract: Amiodarone (A), an unique antiarrhythmic agent and amphiphilic drug, induces at sublethal doses dyslipidic storage in animals. The present work demonstrates a distinct intestinal pathology or "Malabsorption Syndrome" in the dog induced by A. Signs of intestinal pathology were observed in all animals receiving 100 mg/kg, but not in those receiving less than 50 mg/kg, after one month. The malabsorption syndrome was demonstrated by a dynamic study of lipid absorption and pathological lesions (partial villous atrophy and the accumulation of macrophages with dyslipidic inclusions.
mesh_terms: D000638:Amiodarone / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D001572:Benzofurans / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced; D004285:Dogs; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D050356:Lipid Metabolism; D008264:Macrophages / Q000473:pathology; D008286:Malabsorption Syndromes / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D001572:Benzofurans; D014280:Triglycerides; D000638:Amiodarone