title: Observations on regional cerebral blood flow in cortical and subcortical structures during language production in normal man.
abstract: Regional cerebral blood flow (rCBF) was studied by single photon emission computerized tomography (SPECT) of inhaled xenon-133 in six normal volunteers during various language, articulatory, and control conditions. Language production increased rCBF in predominantly left-sided cortical and subcortical areas. The involved regions were anatomically related to a left frontal area (Broca's), to both caudate nuclei, to a left thalamic/pallidal area, and bilaterally in retrorolandic areas. The failure to demonstrate lateralized retrorolandic activity is thought to reflect the complexity of the tasks.
mesh_terms: D000328:Adult; D002421:Caudate Nucleus / Q000098:blood supply; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory / Q000502:physiology; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000098:blood supply; D013788:Thalamus / Q000098:blood supply; D014055:Tomography, Emission-Computed; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes