Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives.
Two common cross-reacting anti-DNA antibody idiotypes designated 16/6 and 32/15, previously identified in the serum of patients who have systemic lupus erythematosus, were found in 24% and 7%, respectively, of 147 first-degree relatives. These findings imply that high-frequency germ-line genes exist among lupus relatives, as well as patients. These dominant or public anti-DNA antibody idiotypes are not likely to be pathogenic factors, but are probably a genetically associated phenomenon.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D003429:Cross Reactions; D004247:DNA / Q000235:genetics / Q000276:immunology; D005190:Family; D005260:Female; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male
D000974:Antibodies, Antinuclear; D007130:Immunoglobulin Idiotypes; D004247:DNA