Study of rosin glycerol esters as microencapsulating materials.
Rosin esters were prepared by heating rosin with glycerol and intermediate reaction products with different acid values were withdrawn. Salicylic acid granules were encapsulated using a 10 per cent solution of rosin esters in acetone. The coated microcapsules were evaluated for moisture absorption, flow properties and dissolution studies. The results showed that rosin and rosin-glycerol intermediates with acid values of 122, 105 and 55 had excellent moisture protection properties. Dissolution studies showed that these could be used for delayed release of drug.
D004339:Drug Compounding / Q000379:methods*; D005990:Glycerol; D012116:Resins, Plant; D012459:Salicylates / Q000008:administration & dosage; D020156:Salicylic Acid; D012995:Solubility
D012116:Resins, Plant; D012459:Salicylates; C013893:rosin; D020156:Salicylic Acid; D005990:Glycerol