title: Repair of aortic coarctation in infants: experience with an intraluminal shunt.
abstract: From 1962 to mid-1984, 63 infants underwent coarctation repair. Cardiac defects were present in 46 (73%). Repair was by subclavian aortoplasty in 35 patients, resection and end-to-end anastomosis in 19, and other techniques in 6. Three patients died before the repair was completed. In 15 patients, an intraluminal shunt was used during subclavian aortoplasty. Prostaglandin E1 (PGE1) was infused in 9 patients. Early (thirty-day) mortality was 16% (10 patients): 4 patients who underwent end-to-end anastomosis; 3 during attempted end-to-end anastomosis; 2 who received bypass grafts; and 1 who had subclavian aortoplasty without a shunt. None of the 15 patients who had subclavian aortoplasty with a shunt died. There were no early deaths among the last 25 patients seen. One patient who underwent subclavian aortoplasty without a shunt is paraplegic. There were 10 late deaths among the 53 patients followed from 1 month to 12 years (mean, 3 years). Arm-leg pressure gradients of 20 mm Hg or greater were found in 4 of the patients who had end-to-end anastomosis but not in any of the patients who had subclavian aortoplasty. Improved results of coarctation repair in infants in this study were attributed to PGE1, subclavian aortoplasty, and use of an intraluminal shunt.
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000209:etiology; D000527:Alprostadil; D001013:Aorta, Thoracic / Q000601:surgery*; D001017:Aortic Coarctation / Q000150:complications / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000209:etiology; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010264:Paraplegia / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology; D011458:Prostaglandins E / Q000627:therapeutic use; D013348:Subclavian Artery / Q000601:surgery*; D013536:Suture Techniques; D014656:Vascular Surgical Procedures / Q000295:instrumentation
chemical_list: D011458:Prostaglandins E; D000527:Alprostadil