Combination perfusion-cold storage for optimum cadaver kidney function and utilization.
Dog kidneys were perfused with a newly developed perfusate containing adenosine and PO4 for 48 hr, stored in the same perfusate for an additional 24 hr without perfusion (total preservation time:72 hr), and transplanted with immediate contralateral nephrectomy. Posttransplant renal function and biochemical analysis of the kidneys revealed practically no additional preservation-induced damage during the cold storage period. Serum creatinine levels reached normal between the third and eighth day posttransplant. This preservation method may be the method of choice for patients receiving postoperative cyclosporine therapy--and, in addition, facilitate organ sharing between transplant centers, thus reducing wastage of cadaveric kidneys.
D000818:Animals; D003080:Cold Temperature; D003404:Creatinine / Q000097:blood; D004285:Dogs; D005260:Female; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D010477:Perfusion; D014021:Tissue Preservation / Q000379:methods*
D003404:Creatinine