[Investigation of the concentration of cefmenoxime transferred to human serum and tissues in oral region].
The concentration transferred to human serum and tissues in oral region after the administration of cefmenoxime (CMX) were investigated. The results were obtained as follows: The mean values of CMX-concentrations in serum at 15, 30, 60, 120 and 180 minutes after the intravenous administration of 20 ml of 5% glucose solution containing 1 g of CMX were 84.1, 52.7, 28.2, 12.7 and 8.81 micrograms/ml, respectively. The half-life times of serum concentration at T1/2 alpha and T1/2 beta were 0.55 and 1.05 hours, respectively. The mean concentrations transferred to gingiva at 15 (1 case), 30, 60 and 120 minutes after the intravenous administration of the same dose of CMX were 49.2, 14.1, 9.93 and 3.48 micrograms/g, respectively. Moreover, the ratios (tissue concentration to serum concentration) were also 67.50, 27.95, 38.46 and 32.28% at each time, respectively. CMX was administered intravenously for postoperative treatments of 13 patients, resulting in good effect from the laboratory data and clinical findings. No side effects were obtained.
D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D004341:Drug Evaluation; D006801:Humans; D009055:Mouth / Q000378:metabolism*; D013530:Surgical Wound Infection / Q000517:prevention & control
D015281:Cefmenoxime; D002439:Cefotaxime