[Effect of vinblastine and cyclophosphamide on the formation of antigen-induced B-suppressors].
Seven days after administration of sheep red blood cells (SRBC) to CBA and (CBA X C57BL/6) F1 mice antigen-induced B-suppressors are formed in the spleen. These suppressors are capable of inhibiting the unirradiated syngeneic recipients' response to SRBC. Administration to donors to vinblastine (1.5 mg/kg) concurrently with SRBC did not affect and partially reversed, 5 days after SRBC, the formation of antigen-induced suppressors. On the contrary, administration to donors of cyclophosphamide (20 mg/kg) 24 h prior to SRBC or in a dose of 250 mg/kg concurrently with SRBC or 5 days after SRBC completely reversed the formation of antigen-induced suppressors.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects*; D008231:Lymphopenia / Q000139:chemically induced; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors; D014747:Vinblastine / Q000494:pharmacology*
D014747:Vinblastine; D003520:Cyclophosphamide
Vliianie vinblastina i tsiklofosfamida na induktsiiu antigenindutsirovannykh B-supressorov.