[Is type A behavior modulated by genetic factors regulating magnesium and zinc metabolism? Working hypotheses and preliminary results].
Type A behavior subjects, characterized by a state of self-maintained stress, show a decrease in their red blood cell (RBC) Mg concentration under the effect of stress. On the other hand, blood donors carrying the HLA-Bw35 tissue group exhibit lower RBC Mg values. These observations suggest an association between type A behavior and genetic factors associated with the HLA-Bw35 group. In order to test this hypothesis, 130 blood donors of known HLA groups have been submitted to the Jenkins Activity Survey (JAS) in order to determine their behavioral pattern. Bw35 blood donors reveal less frequently a type B (i.e. non-A) behavioral pattern than do the non-Bw35; this finding fits the initial hypothesis. Bw35 individuals also show lower blood Mg values while those with a high JAS score reveal higher RBC zinc concentrations. A working hypothesis, based on these results, is developed.
D000328:Adult; D000368:Aged; D001782:Blood Donors; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D010553:Personality Development; D014434:Type A Personality; D015032:Zinc / Q000097:blood / Q000378:metabolism*
D006680:HLA Antigens; D015797:HLA-B35 Antigen; D008274:Magnesium; D015032:Zinc
Le comportement de type A est-il modulé par des facteurs génétiques régulateurs du métabolisme du magnésium et du zinc? Hypothèses de travail et résultats préliminaires.