Effect of selective PEEP on pulmonary blood flow following unilateral hydrochloric acid aspiration in the dog.
We investigated the effect of unilateral or bilateral positive end-expiratory pressure (PEEP) on pulmonary perfusion in 12 dogs with a hydrochloric acid aspiration injury of the left lung. The lungs were ventilated separately and PEEP was applied to the left lung at 10 cmH2O (1.0 kPa) in six and at 15 cmH2O (1.5 kPa) in six others. Measurements of the right and left pulmonary arterial blood flows (QR and QL) and venous admixture were made before, during and after PEEP. After this study, 5 and 10 cmH2O (0.5 and 1.0 kPa) PEEP were applied to both lungs in six dogs and measurements were repeated. Following the application of PEEP to the left lung, a significant decrease in QL and increase in QR were observed. However, the application of PEEP to both lungs was followed by significant decreases in both QL and QR. The cardiac output decreased slightly during unilateral PEEP and markedly during bilateral PEEP. The venous admixture decreased significantly during PEEP in all the groups. These findings indicate that selective PEEP causes a transfer of pulmonary blood flow from the injured lung to the normal lung, improving ventilation-perfusion inequality, and improves gas exchange without impeding oxygen delivery.
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D006851:Hydrochloric Acid; D008171:Lung Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen; D011175:Positive-Pressure Respiration / Q000379:methods*; D011652:Pulmonary Circulation; D012119:Respiration; D014692:Ventilation-Perfusion Ratio
D006851:Hydrochloric Acid; D010100:Oxygen