title: Mechanism of recovery from acute virus infection. II. Effect of treatment of mice with cyclosporin A on their ability to eliminate the lymphocytic choriomeningitis virus.
abstract: Illness and death of mice infected by intracerebral inoculation with lymphocytic choriomeningitis virus are pathologic immune phenomena, and mice thus infected were protected when immunosuppressed with cyclosporin A (CSA), although the virus multiplied extensively in all major organs. Concentrations remained high as long as the drug was administered but declined when the treatment was discontinued; also, cytotoxic T lymphocytes appeared. Virus elimination was slower and cytotoxic T cell activity lower than in mice not previously treated with CSA.
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D005260:Female; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects*
chemical_list: D003524:Cyclosporins; D003520:Cyclophosphamide