[Studies on the differentiation of chondrocytes in connection with poly ADP ribose synthesis].
Cell differentiation and the behaviour of poly-(ADP-ribose)-synthesis after treatment with methoxybenzamide and procaine was examined in chondrocytes of cell cultures from albino rats. In this study an increase in cell differentiation was connected with a higher level of poly(ADP-ribose)-synthesis. On the basis of an increase in poly(ADP-ribose)-synthesis in chondrocytes an improved scheme of treatment of some rheumatic diseases could be developed.
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D002356:Cartilage / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D009702:Nucleoside Diphosphate Sugars / Q000096:biosynthesis*; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis*; D011343:Procaine / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
D001549:Benzamides; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose; D011343:Procaine; C025159:3-methoxybenzamide
Untersuchungen über Differenzierungsvorgänge an Chondrozyten im Zusammenhang mit der Poly(ADP-Ribose)-Synthese.