Alpha 1-antitrypsin-Pittsburgh: a potent inhibitor of human plasma factor XIa, kallikrein, and factor XIIf.
AT-P is a potent inhibitor of factor XIa. It has a greater affinity for factor XIa (5.1 X 10(5) M-1 sec-1), than it does for thrombin (3.1 X 10(5) M-1 sec-1). This recently cloned protein may be clinically valuable in the management of disorders involving activation of the contact system of plasma proteolysis.
D005172:Factor XI / Q000037:antagonists & inhibitors*; D005174:Factor XII / Q000037:antagonists & inhibitors*; D015945:Factor XIa; D006801:Humans; D007610:Kallikreins / Q000037:antagonists & inhibitors*; D007700:Kinetics; D000515:alpha 1-Antitrypsin / Q000302:isolation & purification* / Q000502:physiology
D000515:alpha 1-Antitrypsin; C038915:alpha 1-antitrypsin Pittsburgh; D005174:Factor XII; D005172:Factor XI; D007610:Kallikreins; D015945:Factor XIa