[Association of HLA antigens with scleroderma].
22 patients suffering from scleroderma have been investigated with regard to possible association of HLA with scleroderma (PSS and s. circumscripta). Preliminary data revealed increased relative risk values for carriers of the HLA antigens DR1 and DR5 (rR value 6.3 and 2.6 for PSS, resp.). In s. circumscripta, the rR value of individuals positive for B27 was increased up to 4.9. Different subtypes of scleroderma seem to be associated with different HLA antigens.
D003601:Cytotoxicity Tests, Immunologic; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D012594:Scleroderma, Localized / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000276:immunology*
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D015798:HLA-DR1 Antigen; D000949:Histocompatibility Antigens Class II
Assoziation von HLA-Antigenen und Sklerodermie.