title: Effect of the C1q on the soluble collagen-platelet interaction.
abstract: The mechanism by which C1q inhibited soluble collagen-induced platelet aggregation was examined. Platelet aggregation induced by soluble collagen in gel filtrated platelets was inhibited by the addition of C1q. There were no cross-reactions between C1q, purified soluble collagen receptor and both of their polyclonal antibodies in enzyme-linked immunosorbent assays. These results suggest that the effect of C1q on soluble collagen-induced platelet aggregation does not compete at the same binding site on the platelet surface.
mesh_terms: D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D003166:Complement Activating Enzymes / Q000276:immunology / Q000494:pharmacology*; D015922:Complement C1q; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008970:Molecular Weight; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D038981:Receptors, Collagen; D011971:Receptors, Immunologic / Q000276:immunology
chemical_list: D038981:Receptors, Collagen; D011971:Receptors, Immunologic; D015922:Complement C1q; D003094:Collagen; D003166:Complement Activating Enzymes