[Role of neuroallergy in the pathogenesis of multiple sclerosis].
The neurotropic effects of sera were determined in patients with multiple sclerosis and in animals with experimental allergic encephalomyelitis (EAE) using some newly devised methods. When multiple sclerosis and EAE were at the stage of exacerbation, the kallikrein-kinin system was activated and immune complexes content in the blood serum increased. The authors conclude that neuroallergy plays the major role in the development of multiple sclerosis exacerbations and that the devised methods are valuable for the laboratory confirmation of multiple sclerosis diagnosis.
D000818:Animals; D016282:Aspartic Acid Endopeptidases; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000378:metabolism; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004285:Dogs; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology; D010450:Endopeptidases / Q000097:blood; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000096:biosynthesis; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology; D011817:Rabbits; D051381:Rats
D001323:Autoantibodies; D008054:Lipid Peroxides; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases
Rol' neĭroallergii v patogeneze rasseiannogo skleroza.