T lymphocytes, monocytes and erythropoiesis disorders in chronic renal failure.
The T lymphocytes, OKT4-depleted T lymphocytes, monocytes, macrophages and the bone marrow early erythroid progenitor (BFU-E) interactions have been evaluated in normal subjects and in uremic patients in predialysis phase (PDP), on hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). In the same subjects the T-cell growth factor (TCGF) activity and the T-cell subset identification have also been assessed. The results show in uremic patients, particularly in the presence of reduced OKT4 subset and TCGF activity, a blockage of the interactions between immunocompetent and bone marrow cells which normally could stimulate early erythroid progenitor growth. Since this blockage is partially removed by CAPD, this may suggest a more efficient removal of an interaction inhibitor with CAPD than with other dialysis techniques. The mechanism by which such a material may act appears unclear, but it is possible to suppose an inhibiting activity on the production of TCGF by lympho-monocyte cells which under normal conditions could be considered as an early erythropoiesis regulatory factor.
D000328:Adult; D000911:Antibodies, Monoclonal; D002469:Cell Separation; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D008264:Macrophages / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000502:physiology*
D000911:Antibodies, Monoclonal; D007376:Interleukin-2