Rheumatic fever-associated B cell alloantigens as identified by monoclonal antibodies.
Mice immunized with B lymphocytes obtained from patients who had had well-documented rheumatic fever in the past yielded 2 monoclonal antibodies, termed 83S19.23 and 256S10, which identified certain alloantigens present on the B cells of these patients. The frequency of the B cell marker detected by clone 83S19.23 in rheumatic fever patients was found to be 59%, 77%, and 74% in India, New Mexico, and New York, respectively. Monoclonal antibody 256S10 identified 75% of those rheumatic fever patients who were nonreactive to clone 83S19.23. Thus, the 2 antibodies identify approximately 92% of all rheumatic fever patients and suggest the presence of a diallelic genetic marker for susceptibility to rheumatic fever.
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells; D006801:Humans; D006825:Hybridomas; D007194:India; D007519:Isoantigens / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology*; D014481:United States
D000911:Antibodies, Monoclonal; D007519:Isoantigens