[Delayed hypersensitivity reaction to rat xenoantigens in mice].
A scheme of delayed-type hypersensitivity (DTH) to xenogeneic lymphoid cells induced in mice was suggested. Subcutaneous injection of normal mice with 5 X 10(6) rat spleen cells in a complete Freund's adjuvant with the results evaluated 5 days after was found the optimal condition for DTH development. Mediated by T lymphocytes the response was shown to be maximal 24 hours after the challenge.
D000818:Animals; D015478:Antigens, Heterophile / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization / Q000379:methods; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000276:immunology / Q000637:transplantation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous
D015478:Antigens, Heterophile
Reaktsiia giperchuvstvitel'nosti zamedlennogo tipa k ksenoantigenam krys u mysheĭ.