[Use of human fibrin glue in the closure of vesicovaginal fistulas].
This report describes animal experiments on the use of human fibrin adhesives to close vesicovaginal fistulas artificially created in 20 rabbits. In one group of 10 animals one of the usual closure techniques was supplemented by application of fibrin adhesive to the suture line, whereas in the control group of 10 animals the fistula was closed using only the same usual suture technique. The results were evaluated according to pathoanatomical and histological criteria. In the control group a vesicovaginal fistula recurred in 30% of the animals, whereas the test group showed 100% closure during the observation period.
D000818:Animals; D002921:Cicatrix / Q000473:pathology; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D011817:Rabbits; D012008:Recurrence; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000473:pathology; D014621:Vagina / Q000473:pathology; D014719:Vesicovaginal Fistula / Q000473:pathology / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin
Anwendung des Humanfibrinklebers beim Verschluss von Blasen-Scheiden-Fisteln.