Post-partum thyroiditis and goitrous (Hashimoto's) thyroiditis are associated with HLA-DR4.
Using new panels of HLA-DR typing sera, we found an increase in the prevalence of HLA-DR4 in 21 patients with Hashimoto's thyroiditis (57%) and 32 patients with post-partum thyroiditis (53%) compared to controls (21%). Hashimoto's thyroiditis was previously found to be associated with HLA-DR5 and Dw5. We feel that the doubts raised by this study warrant the study of DR antigens in thyroid autoimmune disease using large panels of specific sera.
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006111:Graves Disease / Q000235:genetics; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011644:Puerperal Disorders / Q000276:immunology*; D013966:Thyroiditis / Q000235:genetics / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000235:genetics / Q000276:immunology*
D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II