Toxicokinetics of the herbicide dichlorprop and its leucinate and their action on liver mixed function oxidase in rats.
The concentrations of dichlorprop and its leucine conjugate in serum and bile of rats have been determined at different periods after a single oral dosage of these compounds (30 or 300 mg/kg body weight). From the results it can be concluded that dichlorprop is excreted by active renal mechanisms resembling that described for 2,4,5-T. It is suggested that the leucinate is excreted more by the biliary route. Investigations of the liver demonstrate that both compounds are able to induce mixed function oxidases.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001646:Bile / Q000032:analysis; D004790:Enzyme Induction / Q000187:drug effects; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007930:Leucine / Q000378:metabolism / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
C047793:dichlorprop-leucine conjugate; D015084:2,4-Dichlorophenoxyacetic Acid; D006899:Mixed Function Oxygenases; D007930:Leucine; C010571:dichlorprop