Brain and liver monoamine oxidase type A and type B activity in alcoholics and controls.
Monoamine oxidase activity in human postmortem brain and liver samples was measured in a group of patients with a prior history of alcoholism and compared to a control group with no prior history of alcoholism. Liver samples from patients with a prior history of alcoholism showed significantly lower monoamine oxidase activity with both phenylethylamine and serotonin as substrates. Postmortem brain samples, however, were not different in the two groups.
D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000201:enzymology*; D001921:Brain / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013379:Substrate Specificity
D010627:Phenethylamines; D012701:Serotonin; D008995:Monoamine Oxidase