Studies on prevention of intra-abdominal adhesion formation by fibrin sealant. An experimental study in rats.
The preventive effect of fibrin sealant on post-operative formation of peritoneal adhesions was investigated in rats. Intraperitoneal adhesion formation was induced with a standardized, sutured defect in the peritoneum. The influence of sealant thickness and lifetime was evaluated by application of a thin and a thick layer of fibrin sealant containing high or low concentration of antiplasmin. Assessment of adhesion formation one week post-operatively showed significantly less adhesion to the defects covered with the thick layer of sealant having high or low antiplasmin concentration as compared with defects having only a thin sealant layer or control rats without sealant.
D000818:Animals; D004311:Double-Blind Method; D004338:Drug Combinations / Q000032:analysis / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005176:Factor XIII / Q000032:analysis / Q000627:therapeutic use*; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000032:analysis / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000032:analysis / Q000627:therapeutic use*; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control*; D000979:alpha-2-Antiplasmin / Q000032:analysis
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D000979:alpha-2-Antiplasmin; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin