The role of interleukins in viral inhibition of lymphocyte mitogenesis.
Several different types of retroviruses have been shown to inhibit the lectin-driven blastogenesis of co-incubated mouse spleen cells. This abrogation of responsiveness is infection-independent, and can be obtained using live as well as UV-inactivated virus particles. Levels of both interleukin-1 (IL-1) and T-cell growth factor (TCGF) activities are greatly reduced in cultures of virus co-incubated cells. However, the inclusion of indomethacin in the culture medium, together with virus, enables responsiveness to Concanavalin A to occur at moderately efficient levels. The addition of exogenous IL-1 activity to virus co-incubated cells is also partially restorative to Con A-driven lymphocyte responsiveness, while at the same time restoring levels of detectable TCGF activity to near-control levels. Finally, the inclusion of exogenous TCGF activity also leads to efficient lymphocyte mitogenesis but does not result in increased levels of IL-1.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D007376:Interleukin-2 / Q000378:metabolism / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D011458:Prostaglandins E / Q000494:pharmacology; D012190:Retroviridae / Q000276:immunology*
D007375:Interleukin-1; D007376:Interleukin-2; D011458:Prostaglandins E; D003208:Concanavalin A; D015232:Dinoprostone; D007213:Indomethacin