Tardive dyskinesia in Tourette syndrome.
Three patients are reported who developed oral-buccal-lingual movements typical of tardive dyskinesia while being treated with stable doses of haloperidol for Tourette syndrome. In each case signs resolved within a number of weeks after medication was discontinued. One of the patients experienced recurrence of the dyskinesia during a challenge with phenothiazine tranquilizers. In each case the dose of haloperidol was well within the usual therapeutic range. A strong family history of movement disorders, including Tourette syndrome, was present in each family.
D000293:Adolescent; D000328:Adult; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D006220:Haloperidol / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D005879:Tourette Syndrome / Q000188:drug therapy* / Q000235:genetics
D006220:Haloperidol