A simple colorimetric method for the determination of primaquine metabolites in urine.
A simple method of screening large numbers of urine samples for the presence of primaquine metabolites has been developed using a commercially available diazonium salt reagent and an extraction cartridge. The extraction requires only 1.0 ml of urine and is selective for acidic or neutral primaquine metabolites. With primaquine-dosed rats, primaquine metabolites could be detected 36 hours after administration of the drug. The sensitivity of the method was found to be approximately 400 mug/l.
D000818:Animals; D003124:Colorimetry / Q000379:methods; D007202:Indicators and Reagents; D008297:Male; D011319:Primaquine / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains
D007202:Indicators and Reagents; D011319:Primaquine