Effect of epidermal growth factor on glucosamine-6-phosphate synthetase activity in the colon of neonatal mice.
Epidermal growth factor (EGF), administered subcutaneously to neonatal mice at daily doses of 1,2 and 4 micrograms/g body weight for 3 days, significantly increased glucosamine-6-phosphate synthetase activity in the colon. A single injection of EGF at doses of 2 and 4 micrograms/g body weight also significantly increased enzyme activity. When administered to mature mice, EGF (4 micrograms/g body weight for 3 days) had no apparent effect on the enzyme activity. From these results, we suggest that EGF acts as a trophic factor for the maturation of the colonic mucosa of neonatal mice.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000378:metabolism*; D003106:Colon / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000254:growth & development; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013268:Stimulation, Chemical
D004815:Epidermal Growth Factor; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D002238:Carbohydrate Epimerases