title: [Pathogenesis of the venous leg ulcer].
abstract: Based on different experimental findings, the following sequence of pathogenetically important factors for the development of venous ulcers is outlined: Valvular incompetence, reflux----chronic venous ambulatory hypertension----capillary dilatation and deformation----hyperemia----increased transendothelial passage (protein), microlymphangiopathy----protein deposition in the tissue. Deficient fibrinolysis----pericapillary fibrin cuffs----diffusion block----local hypoxia, tissue death. Although other mechanisms and complex factors may also play important additional roles, for the first time a reasonable explanation can be offered for the development of venous ulcers that is in agreement with all consistent findings.
mesh_terms: D002196:Capillaries / Q000473:pathology; D002199:Capillary Permeability; D006801:Humans; D006940:Hyperemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D000860:Hypoxia / Q000150:complications; D007871:Leg Ulcer / Q000209:etiology* / Q000628:therapy; D008206:Lymphatic Diseases / Q000150:complications; D010991:Plethysmography; D014689:Venous Insufficiency / Q000150:complications / Q000175:diagnosis
vernacular_title: Zur Pathogenese des venösen Ulcus cruris.