Cell density dependent uptake of LDL in cultured rat hepatocytes.
An inverse relationship between low-density lipoprotein uptake and cell density was observed in rat hepatocyte monolayers incubated with lipoprotein-deficient serum. This was also true for cell association, binding and degradation of low-density lipoproteins. Compactin stimulated cell association and degradation of low-density lipoproteins both at low and high concentrations. Insulin, on the other hand, had no consistent effect on low-density lipoprotein cell association or degradation.
D000818:Animals; D002452:Cell Count; D002478:Cells, Cultured; D007328:Insulin / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D013997:Time Factors
D007328:Insulin; D008077:Lipoproteins, LDL