The specificity of base-pair substitution induced by the mutL and mutS mutators in E. coli.
The Escherichia coli mutator alleles, mutL and mutS, produced transversion as well as transition base-pair substitutions with the trpA reversion system. Transversions, however, were generally mutator-induced at a lower level than transitions and the specific type of transversion and its nucleotide position appeared to strongly affect its level of enhancement. These results are interpreted to mean that mutL- and mutS-dependent mismatch correction is generally more effective at correcting transition mispairings than transversion mispairings. Correction of transversion mispairings is probably dependent upon site of occurrence and type of mismatch.
D004260:DNA Repair; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D005798:Genes, Bacterial; D009154:Mutation; D009876:Operon; D014364:Tryptophan / Q000235:genetics
D004269:DNA, Bacterial; D014364:Tryptophan