title: Malignant pyoderma.
abstract: Malignant pyoderma is a destructive, ulcerating skin disease that occurs chiefly in young adults. Only eight cases of this rare disease have been reported. The head and neck have been involved in all cases, and a predilection for the periauricular region has been noted in several of the cases. Although the disease is progressive and chronic, responses to high-dose systemic corticosteroids have been noted, but usually a flare is associated with a reduction in dose. An additional case is described in which therapy with isotretinoin and sulfapyridine led to complete remission.
mesh_terms: D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007536:Isomerism; D015474:Isotretinoin; D008297:Male; D008875:Middle Aged; D011711:Pyoderma / Q000188:drug therapy*; D013424:Sulfanilamides / Q000627:therapeutic use*; D013427:Sulfapyridine / Q000627:therapeutic use*; D013997:Time Factors; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D013424:Sulfanilamides; D014212:Tretinoin; D015474:Isotretinoin; D013427:Sulfapyridine