Leukemogenesis and differentiation.
The development of systems for the cloning and clonal differentiation of normal hematopoietic cells in culture made it possible to study the controls that regulate normal growth and differentiation and the changes in these controls in leukemia. Identification of the changes in normal controls that occur in leukemia reveals that the stopping of growth by inducing differentiation of malignant cells can by-pass genetic changes that produce the malignant phenotype. The induction of differentiation in leukemic cells can therefore be a useful approach to therapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis; D002454:Cell Differentiation; D002999:Clone Cells; D003115:Colony-Stimulating Factors / Q000032:analysis / Q000096:biosynthesis / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D051379:Mice
D000970:Antineoplastic Agents; D003115:Colony-Stimulating Factors; D003561:Cytarabine; D003907:Dexamethasone