Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis.
Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages.
D000327:Adsorption; D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000097:blood; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology; D013582:Synovial Fluid / Q000032:analysis / Q000166:cytology / Q000502:physiology*; D013585:Synovitis / Q000097:blood / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D014947:Wounds and Injuries / Q000150:complications*
D007375:Interleukin-1; D008075:Lipoproteins, HDL; D000493:Allopurinol