Evaluation of red cell damage during cardiopulmonary bypass.
In patients undergoing cardiopulmonary bypass (CPB), red cell damage was assessed by simultaneous measurement of of plasma-haemoglobin (P-Hb) and red cell filtration rate (RFR) (1). RFR was significantly reduced after 120 min as compared with 30 min (17.4 +/- 4.1 vs. 30.4 +/- 2.9 microliters/s). P-Hb, by contrast, was significantly higher at 60 min than at 30 min after start of CPB (195 +/- 27.2 vs. 73.8 +/- 8.1 microliters/s). Significant negative correlation was found between RFR and P-Hb (r = 0.68). Red cell deformability thus permitted qualitative assessment of red cell trauma during CPB and thereby an estimation of the rheologic disturbance caused to these cells by CPB during open-heart surgery.
D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D004907:Erythrocyte Deformability; D004912:Erythrocytes; D005069:Evaluation Studies as Topic; D005260:Female; D006351:Heart Valves / Q000601:surgery; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D006454:Hemoglobins