Anti-SSA(Ro) antibody: a connective tissue disease marker.
The characteristics of 100 patients with anti-SSA(Ro) antibody were studied. By accepted criteria 34 patients had systemic lupus erythematosus, 25 had other known connective tissue diseases (CTD) and 9 had no significant evidence of a CTD. Thirty-two patients had an unclassified CTD characterized in most instances by arthritis, dermatitis, and a positive fluorescent antinuclear antibody test. The results support the concept of a continuous spectrum of autoimmune disease in which anti-SSA(Ro) antibody may be a marker and in which a variety of disorders may be found that cannot be classified by accepted criteria.
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000032:analysis; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012699:Serology; D012877:Skin Manifestations; D000099207:SS-A Antigen
D000906:Antibodies; D000974:Antibodies, Antinuclear; D000941:Antigens; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human