Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.
A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into acute leukaemia was associated with the emergence of trisomy 8 and der(8)(8qter----cen----8p11::9q34----9qter). This is the third reported case of t(8;9) (p11;q34) and raises the question of the role of c-abl in the pathogenesis of this myeloproliferative disorder.
D000328:Adult; D002871:Chromosome Banding; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D011519:Proto-Oncogenes; D014178:Translocation, Genetic