Analgesics for pain relief after gynaecological surgery. A two-phase study.
A two-phase, double-blind study was performed to assess the efficacy of various drugs in the relief of postoperative pain. Oral analgesia with two compounds (paracetamol 320 mg, caffeine 32 mg, codeine phosphate 8 mg and meprobamate 150 mg (Stopayne; Rio Ethicals) and dipyrone 500 mg, pitofenone hydrochloride 5 mg and fenpiverinium bromide 0,1 mg (Baralgan HS; Albert)) was found to produce satisfactory pain relief, and it is suggested that these oral compounds may be used from 12 hours postoperatively in uncomplicated cases. Parenteral administration of either pethidine 100 mg or dipyrone 2500 mg was found to be an ineffective form of pain relief, and it is suggested that the use of these drugs should be reviewed. In both phases of the study side-effects were infrequent and mild, and smoking did not have an influence on the results.
D000082:Acetaminophen / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D001577:Benzophenones / Q000627:therapeutic use; D002110:Caffeine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003061:Codeine / Q000627:therapeutic use; D004177:Dipyrone / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007273:Injections, Intramuscular; D008614:Meperidine / Q000627:therapeutic use; D008620:Meprobamate / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use; D011897:Random Allocation; D012907:Smoking; D013997:Time Factors
D000700:Analgesics; D001577:Benzophenones; D004338:Drug Combinations; D010880:Piperidines; C044907:Stopayne; D000082:Acetaminophen; D002110:Caffeine; D004177:Dipyrone; C002416:fenpiverinium bromide, pitofenone hydrochloride, dipyrone drug combination; D008614:Meperidine; D008620:Meprobamate; D003061:Codeine