title: Host responses to bacteria and bacterial products in periodontal disease: immunosuppressive effects of periodontitis-related microorganisms?
abstract: Several recent investigations indicate that some patients with adult periodontitis have lowered serum antibody levels or reduced lymphoproliferative responses to certain periodontitis-related microorganisms. Many such patients tend to show increased responses after therapy. Some suggested mechanisms of such responses are reviewed and the possible significance of immunosuppressive effects of periodontitis-related microorganisms are briefly discussed.
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial; D005674:Fusobacterium Infections / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D010518:Periodontitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M