A case of gastric carcinoma associated with excessive granulocytosis. Production of a colony-stimulating factor by the tumor.
A patient with gastric carcinoma exhibited an excessive granulocytosis (58,000/microliter) preoperatively, in the absence of overt infection. After resection of the primary tumor, the peripheral leukocyte count decreased promptly to the normal value. In a search for a colony-stimulating factor (CSF), the tumor was transplanted into nude mice. A marked neutrophilia was observed in the tumor-bearing mice, suggesting the production of CSF by the tumor. Media conditioned by the primary culture of the tumor cells revealed the presence of CSF activity as well. CSF-producing carcinomas have been detected in various organs; nevertheless, no cases of gastric carcinoma have hitherto been described. It is of particular interest that in this patient hypercalcemia was not observed, although it often accompanied CSF-producing tumors reported previously. Therefore, it is suggested that this tumor secreted pure CSF and that the CSF produced by the tumor did not necessarily induce hypercalcemia.
D000368:Aged; D000818:Animals; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D003470:Culture Media; D006801:Humans; D007964:Leukocytosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology
D003115:Colony-Stimulating Factors; D003470:Culture Media