The in vivo evaluation of poly(lactic acid) microcapsules of pilocarpine hydrochloride.
Poly(lactic acid) microcapsules of pilocarpine hydrochloride were prepared and evaluated by measuring a miotic effect in rabbits. The microcapsule suspension showed prolongation of miosis and an improved bioavailability when compared with a standard eye dosage form.
D000818:Animals; D002214:Capsules; D005260:Female; D007773:Lactates; D019344:Lactic Acid; D010862:Pilocarpine / Q000008:administration & dosage* / Q000494:pharmacology; D011091:Polyesters; D011108:Polymers; D011680:Pupil / Q000187:drug effects; D011817:Rabbits
D002214:Capsules; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D010862:Pilocarpine; D019344:Lactic Acid; C033616:poly(lactide)