title: Papillary and cystic neoplasm of the pancreas--an acinar cell tumour?
abstract: Two cases of papillary and cystic neoplasm of the pancreas (PCN) occurring in 17 and 21 year old women are reported with ultrastructural and immunohistochemical findings. A review of the English literature shows that although potentially malignant, PCN, which occurs mainly in young women, is amenable to surgical cure. The significance of large PAS positive and alpha-1-antitrypsin positive tumour granules; the lack of specificity of alpha-1-antitrypsin for pancreatic acinar cells; the possibility of acinar differentiation of PCN; and its separation from pancreaticoblastoma are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000032:analysis / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000145:classification / Q000473:pathology*; D014617:Vacuoles / Q000648:ultrastructure; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000515:alpha 1-Antitrypsin