Synthesis and biodistribution of no-carrier-added [1-11C]putrescine.
No-carrier-added [1-11C]putrescine was synthesized in 20% radiochemical yield in a synthesis time of 50 min by the Michael addition of potassium [11C]cyanide to acrylonitrile followed by reduction of the [11C]dinitrile with borane-methyl sulfide complex. Biodistribution in mice at 5, 30, and 60 min showed low uptake in normal brain tissue.
D000818:Animals; D002250:Carbon Radioisotopes; D051379:Mice; D011700:Putrescine / Q000138:chemical synthesis* / Q000378:metabolism; D011854:Radiochemistry; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods
D002250:Carbon Radioisotopes; D011700:Putrescine