Melphalan treatment of human peripheral T cells promotes Ig production by B cells in vitro.
Human blood B lymphocytes were cocultured with autologous T lymphocytes which were pretested with melphalan or adriamycin in the presence of pokeweed mitogen (PWM). Melphalan treatment of the cells produced an increased secretion of IgG and IgM, whereas adriamycin did not.
D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008558:Melphalan / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011043:Pokeweed Mitogens; D004317:Doxorubicin; D008558:Melphalan