Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin.
Human recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) was tested for its ability to induce colony formation in human bone marrow that had been enriched for progenitor cells. In addition to its expected granulocyte-monocyte colony-stimulating activity, the recombinant GM-CSF had burst-promoting activity for erythroid burst-forming units and also stimulated colonies derived from multipotent (mixed) progenitors. In contrast, recombinant erythroid-potentiating activity did not stimulate erythroid progenitors. The experiments prove that human GM-CSF has multilineage colony-stimulating activity.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D003115:Colony-Stimulating Factors / Q000096:biosynthesis / Q000494:pharmacology*; D004247:DNA / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004900:Erythroblasts / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology*; D013234:Stem Cells / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D004247:DNA