Corticotropin-releasing factor inhibits gastric emptying in dogs.
The purpose of the present study was to evaluate the effect of ovine corticotropin-releasing factor (CRF) on the gastric emptying of a saline meal in conscious dogs. Intravenous infusion of CRF (220-880 pmol . kg-1 . h-1), induced a significant linear dose dependent inhibition of gastric emptying (16-71%). CRF action was not modified by naloxone and not associated with vomiting or other side effects. Intravenous infusion of sulfated cholecystokinin octapeptide (CCK-8, 50-200 pmol . kg-1 . h-1) inhibited gastric emptying by 29-52%. The relative potency of CRF with respect to CCK-8 is 4 times less. These studies demonstrated that CRF given intravenously in picomolar amount inhibits gastric emptying of a liquid meal in dogs through a mechanism unrelated to opiates. The role of endogenous CRF in stress-induced inhibition of gastric emptying needs to be investigated.
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D007700:Kinetics; D009270:Naloxone / Q000494:pharmacology; D012756:Sheep; D012844:Sincalide / Q000494:pharmacology
D009270:Naloxone; D003346:Corticotropin-Releasing Hormone; D012844:Sincalide