Occurrence of antibodies against gene products of the major histocompatibility complex in normal sera of diabetes-prone BB rats.
Natural antibodies were detected in normal sera of diabetes-prone rats of substrain dp BB/DK (19.5%), non-diabetes-prone ndp BB/PhiK (17.8%) and their ancestral randombred strain WOK (2.2-7.5%). These antibodies were haemagglutinins specifically reacting with antigenic products of the RT1.A region, mainly with products of RT1.Aa,d,f haplotypes. The possible causes of this unusual finding are discussed.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D006649:Histocompatibility Antigens / Q000276:immunology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains
D000906:Antibodies; D006388:Hemagglutinins; D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat