title: Atypical histiocytic granuloma. Light microscopic, ultrastructural, and histochemical findings in an unusual pseudomalignant reactive lesion of the oral cavity.
abstract: Four cases of an ulcero-proliferative lesion of putative histiocytic origin, arising in the oral cavity, are described. This lesion, which has not been defined previously, is easily confused histologically with a malignant process of lymphoid origin, thereby representing a pseudolymphomatous proliferation. Light microscopic, ultrastructural, and histochemical characteristics including immunoglobulin negativity, positive esterase reactivity, and positive peanut lectin binding support a histiocytic origin. These lesions are not associated with systemic disease or dissemination and heal spontaneously despite their worrisome microscopic appearance.
mesh_terms: D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004950:Esterases / Q000032:analysis; D005260:Female; D005882:Gingival Diseases / Q000473:pathology; D006099:Granuloma / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000378:metabolism; D008047:Lip Diseases / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism / Q000473:pathology*; D019887:Peanut Agglutinin; D014456:Ulcer / Q000473:pathology
chemical_list: D037102:Lectins; D019887:Peanut Agglutinin; D004950:Esterases