Trimipramine in physical illness with depression.
To assess whether tricyclic antidepressants are useful in patients with a serious physical disorder who develop symptoms of major depression, 42 medically ill outpatients who met RDC criteria for endogenous major depression and had a Raskin depression score of at least 7 were studied. The patients were randomly assigned to a 6-week trial of trimipramine or placebo under double-blind conditions. In the placebo group, depressive symptoms improved when the physical disorder improved; in the trimipramine group, improvement was seen in the depressive symptoms even when there was no concomitant improvement in physical condition.
D000275:Adjustment Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D000553:Ambulatory Care; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D003984:Dibenzazepines / Q000627:therapeutic use*; D004194:Disease / Q000150:complications* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D010555:Personality Inventory; D010919:Placebos; D011569:Psychiatric Status Rating Scales; D011614:Psychotherapy, Brief; D014299:Trimipramine / Q000627:therapeutic use*
D003984:Dibenzazepines; D010919:Placebos; D014299:Trimipramine