Familial occurrence of dermatomyositis and progressive scleroderma after injection of a local anaesthetic for dental treatment.
In an 11-year-old boy severe dermatomyositis occurred a few days after injection in the jaw of a local anaesthetic of the amide type for tooth extraction. The patient's grandmother was affected by progressive scleroderma at the age of 34 years, also after injection of a local anaesthetic for dental treatment. Both cases are discussed with special reference to the immuno-genetic aspects of the origin of dermatomyositis.
D000328:Adult; D000766:Anesthesia, Dental / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D002648:Child; D003882:Dermatomyositis / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D015795:HLA-B8 Antigen; D006801:Humans; D008297:Male; D012595:Scleroderma, Systemic / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D012867:Skin / Q000473:pathology
D000779:Anesthetics, Local; D006680:HLA Antigens; D015795:HLA-B8 Antigen