title: Radiation-induced specific locus mutations in human mammary epithelial cells.
abstract: A specific locus mutagenesis assay using primary cultures of human mammary epithelial cells has been developed. A mutation frequency at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus of approximately 2 X 10(-5) mutations per surviving cell per gray of ionizing radiation was estimated in these cells.
mesh_terms: D001940:Breast / Q000166:cytology*; D002478:Cells, Cultured / Q000528:radiation effects; D005260:Female; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D066298:In Vitro Techniques; D009154:Mutation; D011831:Radiation Genetics
chemical_list: D007041:Hypoxanthine Phosphoribosyltransferase