Stellate fibrin-fibronectin microclot formation from keratinocytes and fibroblasts stimulated by plasma from patients with psoriasis.
Plasma from patients with active psoriasis has been shown to induce the formation of stellate fibrin-fibronectin microclots in vitro around cultured keratinocytes and fibroblasts. Such a stellate radiation of fibronectin and fibrin was also demonstrated around monocytes from patients with psoriasis. The phenomenon was not observed in healthy subjects but has been found in various disorders.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D004485:Eczema / Q000097:blood; D000078404:Epidermal Cells; D005337:Fibrin / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007871:Leg Ulcer / Q000097:blood; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood*
D005353:Fibronectins; D005337:Fibrin