title: Sequence analysis of the human major histocompatibility gene SX alpha.
abstract: The DP subregion of the human major histocompatibility complex contains two closely linked gene pairs, DP alpha, DP beta and SX alpha, SX beta. The exon-intron organization and the complete DNA sequence of the SX alpha gene are reported here. There are several mutations within the SX alpha gene which strongly suggest that it is a pseudogene. These include two frameshift mutations, one in the alpha 1 domain and the other in the cytoplasmic domain. A 5' splice site mutation at the end of the alpha 1 exon also exists. DNA sequence homology between DP alpha and SX alpha suggests that these genes arose through a gene duplication event.
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D008040:Genetic Linkage; D006682:HLA-DP Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex; D009154:Mutation; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
chemical_list: D006682:HLA-DP Antigens; D000949:Histocompatibility Antigens Class II; D021382:Protein Sorting Signals