Serum cholesterol binding reserve percentage in diabetes mellitus.
Serum cholesterol binding reserve percentage (SCBR%) in patients with diabetes mellitus (22.17 +/- 13.40%) was significantly lower than in controls (40.93 +/- 8.69%) (p less than 0.001). SCBR% of controls did not vary with age (age range 20-80 years). SCBR% declined significantly with increasing duration of diabetes. It also decreased with macrovascular complications and was lowest in multiple/fatal complications further corroborating the value of SCBR% as a risk indicator of atherogenesis. The relationship of SCBR% with treatment was very striking. All adequately controlled patients had a significantly higher SCBR% than those who were poorly controlled regardless of treatment modality and those adequately controlled on insulin had the highest SCBR%, which was close to that of normal controls.
D000328:Adult; D000368:Aged; D000375:Aging; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL; D003327:Coronary Disease / Q000097:blood / Q000150:complications; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood; D006801:Humans; D008079:Lipoproteins, VLDL / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications
D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol