A particular subset of HLA-DR4 accounts for all or most of the DR4 association in type I diabetes.
Two human T-lymphocyte clones, derived from a mixed leukocyte culture (MLC) with stimulating cells from a type I diabetic patient, define a subset of HLA-DR4, tentatively called "DR4S." In testing of 69 random type I diabetic subjects and 69 random controls, 79% (37/47) of DR4-positive patients, but only 44% (8/18) of DR4-positive controls, had DR4S (P less than 0.01). The relative risk of type I diabetes for DR4S+ individuals was 8.8, while that for DR4+ DR4S- individuals was only 1.0. Thus, in the population tested, DR4S accounts for all or most of the increased frequency of HLA-DR4 in type I diabetes.
D002999:Clone Cells; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology
D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II