title: A platelet factor that stimulates the proliferation of vascular endothelial cells.
abstract: The effects of platelet factors on the growth of cultured porcine aortic endothelial cells were studied. Human platelet lysate stimulated the incorporation of [3H] thymidine into DNA. Gel chromatography on Sephadex G-75 revealed at least two peaks of activity on endothelial cells, the major peak being at an apparent molecular weight of 20,000. This activity was heat-labile and trypsin-sensitive, and did not stimulate the growth of fibro-blasts.
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology; D001779:Blood Coagulation Factors / Q000494:pharmacology*; D001792:Blood Platelets / Q000032:analysis*; D002455:Cell Division / Q000187:drug effects; D002850:Chromatography, Gel; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000166:cytology*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D006801:Humans; D008970:Molecular Weight; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D013552:Swine; D013936:Thymidine / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D010982:Platelet-Derived Growth Factor; D004815:Epidermal Growth Factor; D004247:DNA; D013936:Thymidine