Cilastatin does not alter superoxide dismutase activity.
Cilastatin inhibits dehydropeptidase-I, a zinc metaloenzyme that metabolizes imipenem. Because zinc stabilizes the mammalian superoxide dismutase, we postulated that cilastatin would also inhibit the dismutase. Cilastatin concentrations at levels threefold higher than those expected in urine, however, did not inhibit the superoxide dismutase activity.
D015377:Cilastatin; D003300:Copper / Q000378:metabolism; D003521:Cyclopropanes / Q000494:pharmacology* / Q000652:urine; D004150:Dipeptidases / Q000037:antagonists & inhibitors*; D006801:Humans; D015378:Imipenem; D007700:Kinetics; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors*; D013845:Thienamycins / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism
D003521:Cyclopropanes; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D003300:Copper; D013482:Superoxide Dismutase; D004150:Dipeptidases; D015032:Zinc