Intraperitoneal vancomycin and ceftazidime in the treatment of CAPD peritonitis.
The use of intraperitoneal vancomycin and ceftazidime in the treatment of 64 episodes of CAPD peritonitis is reported. Serum and dialysate antibiotic concentrations were measured in 19 of these and the maximum serum vancomycin level recorded was 30 mg/l. Culture of the dialysate was sterile in 52% of the cases, staphylococci were isolated in 30% and the infection rate during 1983 was 2.22 episodes per patient-year. This antibiotic combination has proven safe and effective and easily administered by the patients.
D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002177:Candidiasis / Q000188:drug therapy* / Q000209:etiology; D002442:Ceftazidime / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D014640:Vancomycin / Q000008:administration & dosage*
D014640:Vancomycin; D002442:Ceftazidime