[Transfer of antibiotics into the liver tissue of infants with hepatic dysfunction].
Transfer of antibiotic (cefmetazole, CMZ) into the liver tissues of the infant with hepatic dysfunction, 6 cases of congenital biliary atresia, 4 cases of congenital bile duct dilatation, 1 case of congenital biliary hypoplasia, hepatic hemangioma and umbilical hernia with congenital heart disease is reported here. CMZ level in the liver tissues with hepatic dysfunction shows extremely low. Our study revealed that poor transfer of CMZ into the liver tissues might be a main cause of the poor excretion of CMZ into the bile in case of jaundiced infant.
D000293:Adolescent; D015311:Cefmetazole; D002513:Cephamycins / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000151:congenital / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male
D002513:Cephamycins; D015311:Cefmetazole