Influence of genotypes at a non-MHC B lymphocyte alloantigen locus (Bu-1) on expression of Ia (B-L) antigen on chicken bursal lymphocytes.
Two inbred lines of chickens known to be identical at the MHC differ in their expression of Ia antigen on cells of the bursa. Line 6 bursas had 23% of intensely staining Ia+ cells while line 7 bursas had a much higher level, 85%. Studies of F4 progeny of line 6(3) X 100 crosses showed that genetic control of the high bursal proportion of Ia+ cells was determined by the Bu-1 alloantigen system. Line 100 is identical to line 7 for the lymphocyte alloantigens identified by the T and B cell reagents used in this study. Tests of F4 heterozygotes at the Bu-1 locus show a dominant effect of the Bu-1b gene in control of a high proportion of strongly staining Ia+ cells in the bursa.
D000818:Animals; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000941:Antigens; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002060:Bursa of Fabricius / Q000166:cytology* / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D005326:Fetal Proteins / Q000235:genetics / Q000276:immunology*; D005838:Genotype; D006023:Glycoproteins; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D007178:Inbreeding
D000911:Antibodies, Monoclonal; D000941:Antigens; D000954:Antigens, Surface; D000961:Antilymphocyte Serum; D005326:Fetal Proteins; D006023:Glycoproteins; D000949:Histocompatibility Antigens Class II; C024533:fetal sulfoglycoprotein antigen, human