Induction of severe autoimmune disease in normal mice by simultaneous action of multiple immunostimulators.
Either of two immunostimulating factors (lpr, lipopolysaccharide) enhanced the pathogenic autoimmune responses of MRL/n mice, but the serologic and immunopathologic characteristics differed. In contrast, either factor acting alone, caused minimal immunopathology in normal mice, despite autoantibody induction. Combined immunostimulation, however, caused fatal glomerulonephritis in normal-background C57BL/6 mice. These results show the profound influence of the background genome on the effects of immunostimulating agents, and show that resistance to autoimmune disease in immunologically normal mice is not absolute.
D000276:Adjuvants, Immunologic / Q000235:genetics / Q000494:pharmacology*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000096:biosynthesis; D000936:Antigen-Antibody Complex / Q000378:metabolism; D001168:Arthritis / Q000209:etiology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D004357:Drug Synergism; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology; D007075:Immunoglobulin M / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D012217:Rheumatoid Factor / Q000096:biosynthesis; D013045:Species Specificity
D000276:Adjuvants, Immunologic; D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D012217:Rheumatoid Factor