title: The patterns of brain gangliosides of Rana catesbeiana during metamorphosis and in the adult.
abstract: Ganglioside patterns were quantitated for brains of bullfrog (Rana catesbeiana) at three stages of metamorphosis and adult. At each stage nine gangliosides were identified by mobility on silica gel thin-layer chromatograms, and quantitated on the basis of sialic acid content. A single band with chromatographic mobility close to that of GD2, and doublets close to GT1b and GQ were quantitatively the major ones (over 16% each). Doublets close to GM1 and GD1b and a single band slightly behind GD1a made up 5-10% each. A doublet comigrating with GM3, and bands close to GM2 (trace) and GD3 were present in smaller amounts. The only developmental trend was a slight increase in the proportion of the band close to GD3 from 2.4% (early prometamorphic phase) to 9.1% (adult). This suggests that changes in the regenerative capacity of frog nervous tissues during metamorphosis are due to changes other than ganglioside composition.
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D002855:Chromatography, Thin Layer; D005732:Gangliosides / Q000032:analysis*; D008675:Metamorphosis, Biological; D011892:Rana catesbeiana; D012794:Sialic Acids / Q000032:analysis; D014018:Tissue Distribution
chemical_list: D005732:Gangliosides; D012794:Sialic Acids