Hairy cell leukemia: a B-lymphocytic disorder derived from splenic marginal zone lymphocytes?
Although there is increasing evidence that the majority of cases of hairy cell leukemia represent B-lymphoproliferative disorders, the exact subset of B-cells from which hairy cells are derived, is still unclear. On the basis of results obtained in previous studies, and data collected from the literature, it is suggested that B-lymphocytes normally residing in the marginal zone of the splenic white pulp (so called 'marginal zone lymphocytes') represent the cell type from which B-lineage derived hairy cells originate.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000145:classification / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D003520:Cyclophosphamide / Q000494:pharmacology; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D008212:Lymphocyte Depletion; D051381:Rats; D013154:Spleen / Q000166:cytology*
D000911:Antibodies, Monoclonal; D003520:Cyclophosphamide