Induction of follicular growth in the squirrel monkey (Saimiri sciureus) with human urinary follicle-stimulating hormone (Metrodin).
Human urinary follicle-stimulating hormone (Metrodin, Serono Laboratories, Inc., Randolph, MA), an investigational drug which is purified from human menopausal gonadotropin (hMG) (Pergonal, Serono Laboratories, Inc.), was tested for its effects on induction of follicle development in the squirrel monkey (Saimiri sciureus). Metrodin was as effective as hMG for induction of follicle development in the squirrel monkey, and it appeared to be superior to hMG or porcine follicle-stimulating hormone at lower dose rates. The percentage of cornified cells in vaginal smears increased during stimulation and showed a parallelism with estrogen levels in serum and with follicular development. The results of the recovery rate of matured ova in different regimens show that use of Metrodin is a most convenient method for induction of follicle development and ovum recovery in the squirrel monkey.
D000818:Animals; D004967:Estrogens / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D008596:Menotropins / Q000494:pharmacology; D009865:Oocytes / Q000254:growth & development; D006080:Ovarian Follicle / Q000254:growth & development*; D010062:Ovulation Induction; D012453:Saimiri; D014626:Vaginal Smears
D004967:Estrogens; D008596:Menotropins; D005640:Follicle Stimulating Hormone