Biopharmaceutic stability of [D-Trp6, des-Gly10]-LHRH ethyl amide in corn oil.
When sperm-positive female rats were treated with freshly prepared formulations of [D-Trp6, des-Gly10]-LHRH ethyl amide (LRA) in corn oil, the effects on pregnancy occurred in a dose-related manner. When the same formulation was retested after five-and-a-half years of storage under refrigeration, the results were essentially identical. Therefore, the biopharmaceutic stability of corn oil formulations of LRA appears to be 100% following five-and-a-half years of storage at 4 degrees C.
D000818:Animals; D003314:Corn Oil; D004355:Drug Stability; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D009821:Oils; D011247:Pregnancy / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives*
D009821:Oils; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C019176:Tryptal; D003314:Corn Oil