Acromegaly associated with suprasellar and pulmonary hemangiopericytomas. Case report.
The authors report the case of a 35-year-old acromegalic woman who developed amenorrhea and decreased left vision, and who was found to have suprasellar and pulmonary hemangiopericytomas. Total removal of the suprasellar hemangiopericytoma resulted in normalization of the plasma human growth hormone (GH) level and a marked decrease in size of the pulmonary hemangiopericytoma. Immunoperoxidase studies for GH and human hypothalamic growth hormone-releasing factor (GHRF) demonstrated immunoreactive intracellular GH only in the suprasellar hemangiopericytoma, with no immunoreactive intracellular GHRF evident in either the suprasellar or pulmonary hemangiopericytoma.
D000172:Acromegaly / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000032:analysis; D013007:Growth Hormone-Releasing Hormone / Q000032:analysis; D006393:Hemangiopericytoma / Q000032:analysis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis / Q000150:complications* / Q000473:pathology; D010911:Pituitary Neoplasms / Q000032:analysis / Q000150:complications* / Q000473:pathology; D012658:Sella Turcica
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone