Influence of nicardipine on blood pressure, renal function and plasma aldosterone in normotensive volunteers.
The influence of the calcium antagonist nicardipine on intrarenal sodium handling and angiotensin II induced secretion of aldosterone was investigated in 18 normotensive volunteers after the first dose and after 1 week of treatment (20 mg three times daily). A short-lasting natriuresis was observed, which was caused by a decreased reabsorption of sodium localised in both proximal and distal tubules. Log plasma renin activity (PRA) fell significantly on each day during angiotensin II infusion, while log-plasma aldosterone (PA) rose significantly. The log PRA/log PA ratio was increased during nicardipine treatment. The secretion of aldosterone, induced by angiotensin II, was not influenced by nicardipine treatment. No effect of the drug on adrenal responsiveness to angiotensin II was found.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009529:Nicardipine; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism
D002121:Calcium Channel Blockers; D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D009529:Nicardipine; D012083:Renin; D009543:Nifedipine