Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin.
Chlamydocin, a potent cytostatic agent against cultured mammalian cells, and HC-toxin, a host-specific phytotoxin, are cyclic tetrapeptides containing the same epoxide alpha-amino acid. We show here that these compounds have reciprocal biological activity; HC-toxin is cytostatic against cultured mastocytoma cells, and chlamydocin has host-specific toxin activity against maize. Chlamydocin and another related cyclic peptide, Cyl-2, are less host-specific than HC-toxin because maize tolerant to HC-toxin is more sensitive to chlamydocin and Cyl-2.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D007700:Kinetics; D012515:Mast-Cell Sarcoma / Q000473:pathology; D008938:Mitosis / Q000187:drug effects; D010456:Peptides, Cyclic / Q000494:pharmacology*; D063245:Plant Development; D010944:Plants / Q000187:drug effects; D014118:Toxins, Biological; D003313:Zea mays
D000903:Antibiotics, Antineoplastic; D010456:Peptides, Cyclic; D014118:Toxins, Biological; C006963:chlamydocin; C037654:HC toxin