Gamma heavy chain disease: report of a case associated with trisomy of chromosome 7.
A case of gamma heavy chain disease is reported in a 52-year-old white male who presented with fever and generalized lymphadenopathy. A lymph node biopsy showed malignant lymphoma. A partial transient response was obtained with cyclophosphamide, vincristine, prednisone, and doxorubicin. He died 3 months after diagnosis from disease progression and infectious complications. Chromosome analysis of cells from an involved lymph node showed the presence of trisomy 7. Chromosome abnormalities have been reported in three of ten previously published cases of gamma heavy chain disease. Trisomy of chromosome #7 has not previously been reported.
D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D006362:Heavy Chain Disease / Q000235:genetics*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014314:Trisomy
D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains