[Metabolic effect of gutimine on the myocardial tissue in blood loss].
A rate of hemorrhage accounted for 31 mg/kg in 80 adult dogs premedicated with promedol and atropine. After circular-hemic hypoxia caused by the hemorrhage, single intravenous administration of gutimine (35-40 mg/kg) transformed the carbohydrate metabolism in heart muscle: activated glycolysis and accelerated the rate of its products oxidation, maintained the free amino acids concentration at the level similar to that of intact animals, reduced the rate of creatine phosphate synthesis.
D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001815:Bloodletting; D050260:Carbohydrate Metabolism; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects; D005971:Glutamates / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006164:Guanylthiourea / Q000494:pharmacology* / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives*
D005971:Glutamates; D001224:Aspartic Acid; D013890:Thiourea; D006164:Guanylthiourea; D009584:Nitrogen
Metabolicheskiĭ éffekt gutimina v tkani miokarda pri krovopotere.