Effect of ketamine on amino acid-evoked release of acetylcholine from rat cerebral cortex in vitro.
N-Methyl-D-aspartate (NMDA), quisqualate, kainate and potassium increased, in a dose-dependent manner, the efflux of radioactivity from rat cerebral cortex minislices preincubated with [3H]choline. Ketamine (1-5 microM) and magnesium (0.1-1 mM) reduced only the release evoked by NMDA. The non-parallel shift of the NMDA dose-response curve suggests that ketamine is not acting as a competitive antagonist of NMDA.
D000109:Acetylcholine / Q000378:metabolism*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D016202:N-Methylaspartate; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats
D000596:Amino Acids; D001224:Aspartic Acid; D016202:N-Methylaspartate; D011189:Potassium Chloride; D007649:Ketamine; D008274:Magnesium; D000109:Acetylcholine; D007608:Kainic Acid