Aluminum in tissues.
Patients with aluminum accumulation show a heterogeneous distribution of the element throughout the body which is different from normals. In chronic renal failure, aluminum has been implicated in dialysis encephalopathy, vitamin D-resistant osteomalacia and microcytic hypochromic anemia. Disparities are observed between aluminum distribution and organ dysfunction. In patients with severe renal failure and aluminum overload, aluminum shows a heterogeneous distribution throughout the brain. The mechanisms of aluminum toxicity remain largely unknown. Desferrioxamine administration results in decreases of tissue aluminum levels and in regression of aluminum-associated pathology.
D000535:Aluminum / Q000009:adverse effects / Q000378:metabolism* / Q000506:poisoning; D000740:Anemia / Q000139:chemically induced; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D001927:Brain Diseases / Q000139:chemically induced; D004347:Drug Interactions; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced; D009420:Nervous System / Q000187:drug effects; D010280:Parathyroid Glands / Q000187:drug effects; D006435:Renal Dialysis / Q000009:adverse effects; D014018:Tissue Distribution
D000535:Aluminum