The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate.
The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins; D004492:Edetic Acid; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000097:blood*; D011506:Proteins / Q000032:analysis*; D012177:Retinol-Binding Proteins / Q000032:analysis; D012216:Rheumatic Diseases / Q000503:physiopathology; D014570:Urologic Diseases / Q000503:physiopathology; D001613:beta 2-Microglobulin / Q000032:analysis
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D011480:Protease Inhibitors; D011506:Proteins; D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D004492:Edetic Acid; D003404:Creatinine