Caffeine induced changes in cerebral circulation.
While the caffeine induced cerebral vasoconstriction is well documented, the effects of oral ingestion of the drug in a dose range comparable to the quantities in which it is usually consumed and the intensity and duration of the associated reduction in cerebral circulation are unknown. Cerebral blood flow was measured via the 133Xenon inhalation technique before and thirty and ninety minutes after the oral administration of 250 mg of caffeine or a placebo, under double-blind conditions. Caffeine ingestion was found to be associated with significant reductions in cerebral perfusion thirty and ninety minutes later. The placebo group showed no differences between the three sets of cerebral blood flow values.
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000000981:diagnostic imaging; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D014661:Vasoconstriction / Q000187:drug effects; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D002110:Caffeine