Reversible hyperkalemia induced by flufenamic acid in asymptomatic hyporeninemic patient.
Reversible hyperkalemia induced by flufenamic acid in an asymptomatic hyporeninemic patient with IgA nephropathy is reported. Flufenamic acid, 600 mg daily, was given for four months to a 64-year-old woman with biopsy proven IgA-nephropathy. This produced hyperkalemia, hypertension and congestive heart failure with slowly progressive renal impairment. We conclude that a further suppression of the renin angiotensin system causing selective hypoaldosteronism together with the nephrotoxic effects of this drug may have been responsible for hyperkalemia in this patient.
D005260:Female; D005439:Flufenamic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005922:Glomerulonephritis, IGA / Q000188:drug therapy; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced*; D008875:Middle Aged; D012083:Renin / Q000097:blood*
D005439:Flufenamic Acid; D012083:Renin