[The pulsatile administration of releasing hormone (GnRH) for the treatment of hypothalamic amenorrhea].
12 women with hypothalamic amenorrhoea (degrees II to IIIb) were given pulsatile releasing hormone in 14 treatment cycles. The minipump "Zyklomat" (Ferring Ges.m.b.H., Kiel) with a treatment set giving 0.8 mg LH-RH was used in all cases. In 86% (12 out of 14) of the treated cycles ovulation was recorded. 3 out of 8 women who desired a baby became pregnant. 1 of these pregnancies followed directly on a treatment cycle whilst the other 2 pregnancies resulted from spontaneous biphasic cycles following the treatment cycle. In 4 women pulsatile releasing hormone was used to examine the functional reaction of the pituitary gland and the ovary. In this group 1 spontaneous biphasic cycle was seen following the induced ovulatory cycle.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D010060:Ovulation / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage*; D011247:Pregnancy
D010906:Pituitary Hormone-Releasing Hormones
Die pulsatile Releasinghormon-(GnRh-)Gabe zur Behandlung der hypothalamischen Amenorrhö.