[Efficacy of troxerutin on the flow properties of blood under defined conditions of circulation. A double-blind study of patients with diabetic retinopathy and arteriosclerotic retinopathy].
In a clinically controlled double-blind study it was demonstrated that tri-(hydroxyethyl)-rutin is not capable of significantly improving blood viscosity or one of its constituent factors. On the basis of data from 58 patients, none of whom was under 43 years old, it was possible to show that the substance tested has no favorable influence on plasma viscosity, erythrocyte deformability and aggregation, or on the concentration of plasma proteins which promote aggregation. Thus, in the very group of patients for whom an improvement in blood flow properties by means of oral administration of tri-(hydroxyethyl)rutin had been hoped for, no therapeutic effect could be demonstrated.
D000328:Adult; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy*; D001798:Blood Proteins / Q000032:analysis; D001809:Blood Viscosity / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003930:Diabetic Retinopathy / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D012164:Retinal Diseases / Q000097:blood / Q000188:drug therapy*; D012431:Rutin / Q000031:analogs & derivatives*
D000925:Anticoagulants; D001798:Blood Proteins; D006896:Hydroxyethylrutoside; D012431:Rutin; C005865:troxerutin
Wirksamkeit von Troxerutin auf die Fliesseigenschaften des Blutes unter definierten Strömungsbedingungen. Eine Doppelblindstudie an Patienten mit Retinopathia diabetica und Retinopathia arteriosclerotica.