Insulin binding on erythrocytes in unsatisfactorily controlled obese diabetics (type 2) and nonobese diabetics (type 1).
Insulin binding to receptors on erythrocytes was studied in 2 groups of poorly controlled diabetics, i.e. a) 9 noninsulin dependent obese diabetics, b) 8 insulin-dependent nonobese diabetics, and in a group of 10 nondiabetic control subjects. The mean binding value in obese diabetics-type 2 was significantly lower than in controls (4.5 +/- 0.4% vers. 7.3 +/- 0.4%), the difference between the control mean value and the mean value in diabetics-type 1 (6.3 +/- 0.8%) was not statistically significant. Compared with the controls, lower numbers of insulin receptors per cell were found in both groups of diabetics (162 +/- 9 vers. 60 +/- 13 and 88 +/- 13, resp.). The lower number of receptors in diabetics-type 1 seems to be counterbalanced, at least partly, by their higher affinity.
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011972:Receptor, Insulin / Q000378:metabolism*; D012016:Reference Values
D007004:Hypoglycemic Agents; D007328:Insulin; D011972:Receptor, Insulin