[Mechanism of the increased insulin sensitivity of rats following physical training].
A rise of sensitivity to insulin was noted in healthy rats living an inactive life in a vivarium as a result of regular physical exercises (swimming with load for 30 min. during one month). It was expressed in a drop of glycemia in response to insulin administration in the presence of glycogen load, in greater glucose consumption and glycogen accumulation by tissues during incubation with insulin, in a lesser rise of C-peptide and insulin levels after glycogen load. Muscular activity was shown to incorporate glucose consumption and oxidation mechanisms unrelated to insulin regulation. Physical exercise resulted in a rise of the activity of enzymes involved in oxidation of glucose metabolism intermediate products in the presence of a decrease in the insulin level. A conclusion has been made that physical exercises determine a decrease in a demand for insulin secretion in response to a rise of the glucose level in the blood resulting in decreased insulinemia and consequently in raising sensitivity to insulin.
D000818:Animals; D005947:Glucose / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D013550:Swimming; D013997:Time Factors; D014018:Tissue Distribution
D007328:Insulin; D006003:Glycogen; D005947:Glucose
O mekhanizme povysheniia chuvstvitel'nosti k insulinu u krys posle fizicheskikh trenirovok.