The effects of cyclooxygenase and lipoxygenase inhibitors on the collagen abnormalities of diabetic rats.
The importance of cyclooxygenase and lipoxygenase pathways in the determination of collagen abnormalities in diabetes was investigated. Pharmacological agents with antiprostaglandin activity, such as indomethacin, naproxen, and aspirin, were able to prevent the rise in thermal rupture time of tail collagen in diabetic rats. Paracetamol was without effect. The action of indomethacin on diabetic collagen was abolished by concurrent administration of sodium benoxaprofen, an inhibitor of lipoxygenase, to the diabetic rats. Collagen abnormalities in diabetes may be regulated by a balance of the cyclooxygenase and lipoxygenase pathways. Antiprostaglandin agents may have a role in the prevention of some diabetic complications.
D000082:Acetaminophen / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism*; D016861:Cyclooxygenase Inhibitors; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009288:Naproxen / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D000082:Acetaminophen; D009288:Naproxen; D003094:Collagen; D001241:Aspirin; D007213:Indomethacin