Transferable resistance to trimethoprim in enteric pathogens isolated in Kuwait.
Trimethoprim resistance was seen in 14.8% of 500 strains of salmonella, 43.1% of 153 strains of shigella and 59% of 27 strains of Escherichia coli isolated from stools of patients with diarrhoea. Strains with a high level of trimethoprim resistance (MIC of much greater than 512 micrograms) were subjected to conjugal transfer. Trimethoprim resistance was plasmid-mediated in all of 42 strains of shigella and 12 strains of E. coli examined. However, 2 of the 47 strains of salmonella could not transfer their trimethoprim resistance either directly or by mobilization with the transfer factors X and delta both at 37 and 25 degrees C overnight incubation.
D003227:Conjugation, Genetic; D003967:Diarrhea / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007730:Kuwait; D008826:Microbial Sensitivity Tests; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D012760:Shigella / Q000187:drug effects / Q000235:genetics; D014295:Trimethoprim / Q000494:pharmacology*
D014295:Trimethoprim