In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones.
MICs of 20 2-acetylpyridine thiosemicarbazones and penicillin were determined for 25 clinical isolates of beta-lactamase-positive and beta-lactamase-negative Neisseria gonorrhoeae strains. The compounds most active against the beta-lactamase-producing strains were the N4,N4-disubstituted derivatives and the thiosemicarbazone derivatives of the 2-acetylpyridines, followed by the other compounds related to the 2-acetylpyridine thiosemicarbazones.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D013882:Thiosemicarbazones; C033836:2-acetylpyridine thiosemicarbazone; D010405:Penicillinase