Renal transplantation in the older recipient.
From 1976 to 1983, 13 living related and 54 cadaver renal transplants were done in 62 patients more than 50 years old. Patients with no coronary or myocardial disease upon coronary angiography were selected preferentially for transplantation. Over-all 1-year patient and graft survival rates were 88 and 70 per cent, respectively. Among cadaver recipients graft survival was improved (p less than 0.001) when prophylactic antilymphoblast globulin was used. There were fewer steroid-related complications (p less than 0.001) in recipients managed with a low dose rather than a high dose maintenance prednisone regimen. With careful patient selection and a steroid-sparing immunosuppressive regimen, renal transplantation can be done safely in older recipients with no increased risk of death or graft loss.
D000367:Age Factors; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D009202:Cardiomyopathies / Q000150:complications; D003327:Coronary Disease / Q000150:complications; D048909:Diabetes Complications; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D006973:Hypertension / Q000150:complications; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012306:Risk; D013997:Time Factors; D014019:Tissue Donors
D000961:Antilymphocyte Serum; D001379:Azathioprine; D011241:Prednisone