Structure of the human vasoactive intestinal polypeptide gene.
Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid hormone produced primarily by neural tissues. The amino acid sequence of VIP is similar to that of a number of gastrointestinal hormones, including glucagon and secretin. VIP is synthesized as part of a polyprotein, pre-proVIP, which generates, in addition to VIP, an additional bioactive peptide known as PHM. As a first step toward understanding the molecular basis of pre-proVIP gene expression, we have isolated the pre-proVIP gene and have determined its structure. The gene is approximately 9 kb long and is interrupted by six introns which appear to divide the gene into functional domains. One of the introns occurs within the 3'-untranslated region of the gene.
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D007340:Insulinoma / Q000235:genetics; D007515:Islets of Langerhans / Q000502:physiology; D010451:Peptide PHI; D010455:Peptides / Q000235:genetics; D011498:Protein Precursors / Q000235:genetics*; D014158:Transcription, Genetic; D014660:Vasoactive Intestinal Peptide / Q000235:genetics*
D010451:Peptide PHI; D010455:Peptides; D011498:Protein Precursors; D014660:Vasoactive Intestinal Peptide; D004247:DNA