[Synthesis and effect of affinity-labeled analogs and partial sequences of the bradykinin potentiating nonapeptide BPP9 alpha (teprotide)].
Affinity labeled analogues and partial sequences of the bradykinin potentiating nonapeptide BPP9 alpha inhibit the BPP9 alpha induced potentiation of the bradykinin action on the isolated guinea pig ileum. The labeled nonapeptides are more active than the labeled partial sequences. The inhibition of the potentiating action of BPP9 alpha demonstrates, that the influence on bradykinin action is not only a result of the inhibition of peptidyl dipeptide hydrolase.
D000345:Affinity Labels / Q000138:chemical synthesis; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004357:Drug Synergism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009842:Oligopeptides / Q000138:chemical synthesis*; D011480:Protease Inhibitors; D013722:Teprotide / Q000138:chemical synthesis* / Q000494:pharmacology
D000345:Affinity Labels; D009842:Oligopeptides; D011480:Protease Inhibitors; D013722:Teprotide; D001920:Bradykinin
Synthese und Wirkung affinitätsmarkierter Analoga und Partialsequenzen des Bradykinin potenzierenden Nonapeptides BPP9 alpha (Teprotide).