Temocillin in the treatment of serious gram-negative infections.
Temocillin was used to treat 32 patients with proven or suspected infection caused by aerobic Gram-negative bacteria. 25 of these patients were assessable on clinical and bacteriological grounds. All 25 were either cured or improved, although in 5 patients with urinary tract infection there was relapse of infection or reinfection following the cessation of therapy. Clinical improvement was usually rapid and no serious side effect was noted. Temocillin would thus appear to be an effective and safe agent for the treatment of bacterial infection caused by aerobic Gram-negative organisms.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D004361:Drug Tolerance; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006090:Gram-Negative Bacteria; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use*; D011512:Proteus Infections / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D010406:Penicillins; C031367:temocillin