[Production of a factor inhibiting macrophage migration to the Candida albicans antigen in mice and their resistance to this microorganism].
Resistance to C. albicans, an opportunistic microorganism, has been studied in CBA and C57BL/6 mice, oppositely responsive in the production of the factor inhibiting migration of macrophages to antigen obtained from this fungus. The study has shown that CBA mice, highly responsive in the macrophage migration inhibiting factor, are less resistant to C. albicans, while C57BL/6 mice with low response to this antigen are more resistant to this infective agent. Macrophages play, probably, a certain role in the generalization of the process because not all phagocytized C. albicans cells are digested.
D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control; D004198:Disease Susceptibility; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis* / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity
D000946:Antigens, Fungal; D008263:Macrophage Migration-Inhibitory Factors
Vyrabotka faktora, ugnetaiushchego migratsiiu makrofagov, u mysheĭ na antigen Candida albicans i ikh rezistentnost' k étomu mikroorganizmu.