Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in the Salmonella/microsome assay.
Several compounds, occurring in food, were tested for antimutagenic activity towards cigarette-smoke condensate (CSC) and benzo[a]pyrene (BaP). Antimutagenicity was determined in the Salmonella/microsome test, with tester strain TA98, in the presence of rat-liver homogenate. Dose-response curves did show reduction of CSC- and BaP-induced mutagenicity by ellagic acid, riboflavin and chlorophyllin. Chlorophyll a and chlorophyll b, although less distinct, also inhibited CSC- and BaP-induced mutagenicity. Ascorbic acid, beta-carotene, tocopherol acetate, chlorogenic acid and butyl hydroxyanisole did not have any influence on the mutagenicity of CSC and BaP. The similarity in results for cigarette-smoke condensate and for BaP indicates that a general mechanism may be involved in the inhibition of CSC- and BaP-induced mutagenicity.
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D002726:Chlorogenic Acid / Q000494:pharmacology*; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077194:Chlorophyll A; D002735:Chlorophyllides / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004610:Ellagic Acid / Q000494:pharmacology*; D008297:Male; D009152:Mutagenicity Tests; D009154:Mutation; D010947:Plants, Toxic; D051381:Rats; D012256:Riboflavin / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D012906:Smoke; D014026:Nicotiana; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*; D019207:beta Carotene
D000840:Anisoles; D001578:Benzopyrans; D002735:Chlorophyllides; D012906:Smoke; D014815:Vitamins; D019207:beta Carotene; D014810:Vitamin E; D002734:Chlorophyll; D004610:Ellagic Acid; D002083:Butylated Hydroxyanisole; D002726:Chlorogenic Acid; D001564:Benzo(a)pyrene; D002338:Carotenoids; C037184:chlorophyll b; C007020:chlorophyllin; D001205:Ascorbic Acid; D012256:Riboflavin; D000077194:Chlorophyll A