Lack of agreement between the salivary flow and finger-sweat print methods for the determination of the anticholinergic effects of antidepressant drugs.
The purpose of the present study was to compare the extent of salivary flow and finger sweating after single acute oral doses of mianserin (30 mg), amitryptiline (75 mg), imipramine (75 mg) and maprotiline (75 mg) and placebo in healthy volunteers in a double-blind assay. Maprotiline and mianserin were less active in reducing salivary flow but were more active than amitryptiline and imipramine in reducing finger sweating. The lack of association between these methods for the measurement of the anticholinergic effect of antidepressant drugs is analyzed in terms of possible mechanisms for the control of palmar sweating.
D000328:Adult; D000639:Amitriptyline / Q000494:pharmacology; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D003878:Dermatoglyphics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D008376:Maprotiline / Q000494:pharmacology; D008803:Mianserin / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects*
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline; D008803:Mianserin; D008376:Maprotiline; D007099:Imipramine