[Rearrangement of the c-myc proto-oncogene locus in a cell line of T-lymphoblastic origin].
A molecular rearrangement of the proto-oncogene c-myc located downstream of the exon III 3' end has been found in a cell line derived from KE37 cell line established from an acute T-lymphoblastic leukemia. This rearrangement resulted from a chromosomal translocation t(8; 14)(q24; q11). Since the 14q11 chromosomal band has been found to be involved in several T-cell leukemias and lymphomas, the importance of the rearrangement of c-myc discovered in the KE37 cell line lies in the possibility of analyzing chromosome 14 DNA near the breakpoint involved in the translocation.
D002460:Cell Line; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15 / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D013601:T-Lymphocytes; D014178:Translocation, Genetic
Remaniement du locus du proto-oncogène c-myc dans une lignée cellulaire d'origine lymphoblastique.