[Experimental (preclinical) study of genetically engineered human interferon based on recombinant clones of E. coli 74 and Pseudomonas Sp VG-84].
The results of the experimental (preclinical) study of interferon alpha2 from Pseudomonas sp VG-84 obtained from the All-Union Research Institute of Genetics and Selection of Industrial Microorganisms in comparison with the preparations of interferon alpha2 from E. coli 74 and natural human interferon (obtained from the Gamaleya Institute of Epidemiology and Microbiology) are presented. Interferon alpha2 from Pseudomonas, a highly purified preparation, has been shown to possess pronounced biological activity (antiviral and antiproliferative) in the culture of human cells. The medicinal form of the preparation has proved to be completely safe and areactive for animals, which makes it possible to recommend the preparation for testing on volunteers.
D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004926:Escherichia coli; D006168:Guinea Pigs; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D007114:Immunization; D007370:Interferon Type I / Q000378:metabolism / Q000633:toxicity*; D007700:Kinetics; D051379:Mice; D011549:Pseudomonas; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000378:metabolism / Q000633:toxicity*; D012882:Skin Tests
D007370:Interferon Type I; D011994:Recombinant Proteins
Eksperimental'noe (doklinicheskoe) izuchenie genno-inzhenernogo chelovecheskogo interferona, poluchennogo na osnove rekombinantnykh klonov E. coli 74 i Pseudomonas Sp VG-84.