The neurotoxicity of radiosensitizing drugs: a biochemical assessment of desmethylmisonidazole (DMM) in the rat.
This study evaluates a major metabolite of misonidazole, desmethylmisonidazole, for its potential to induce peripheral nerve damage using the lysosomal enzyme correlates of neuropathological change, namely beta-glucuronidase and beta-galactosidase. The results showed that desmethylmisonidazole like misonidazole had a similar potential for inducing peripheral nerve damage as measured biochemically, but the dosing regimen had to be maintained for 10 consecutive days as opposed to the 7 days required for misonidazole.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002531:Cerebellum / Q000187:drug effects / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D005966:Glucuronidase / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000201:enzymology; D008920:Misonidazole / Q000031:analogs & derivatives / Q000633:toxicity*; D009593:Nitroimidazoles / Q000633:toxicity*; D010525:Peripheral Nerves / Q000187:drug effects* / Q000201:enzymology; D011838:Radiation-Sensitizing Agents / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D001616:beta-Galactosidase / Q000378:metabolism
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D008920:Misonidazole; D001616:beta-Galactosidase; D005966:Glucuronidase; C009997:desmethylmisonidazole