[Formation of toxic peptides in irradiated rats and their relation to blood serum proteins].
Whole-body gamma-irradiation of rats with a dose of 9.0 Gy caused a 1.5-fold and a 5-fold increase in excretion of basic peptides (molecular mass of 500-2000) in urine on the 2nd and 5th postirradiation days, respectively. These peptides possessed toxic activity and ability to form complexes with macroglobulins, immunoglobulins, and blood serum albumins, in particular. Irradiation decreased binding ability of serum proteins, and preliminary washing thereof by ultrafiltration increased it.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002588:Cesium Radioisotopes; D005720:Gamma Rays; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010455:Peptides / Q000633:toxicity / Q000652:urine*; D011485:Protein Binding; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D014916:Whole-Body Irradiation
D001798:Blood Proteins; D002588:Cesium Radioisotopes; D010455:Peptides
Obrazovanie toksicheskikh peptidov u obluchennykh krys i ikh sviazyvanie s belkami syvorotki krovi.