Mathematical modelling of changes in circulating insulin and C-peptide concentrations.
A simple mathematical model is proposed to assess the validity of methods currently used in clinical investigation to detect short-term or long-term alterations in insulin and/or C-peptide clearance. This model draws attention to unwarranted conclusions which resulted from the analysis of insulin and C-peptide plasma concentrations.
D002096:C-Peptide / Q000097:blood* / Q000378:metabolism; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012636:Secretory Rate; D013997:Time Factors
D002096:C-Peptide; D007328:Insulin