[Aldehyde dehydrogenases in the rat liver after implantation of a prolonged-action preparation of an alcohol deterrent].
Activity of aldehyde dehydrogenase isoenzymes was studied in rat liver mitochondria and microsomes after implantation of the new antialcohol drug of the long-term effect synthesized on the basis of disulphirame. Disulphirame, both in vivo and in vitro was shown to inhibit dissimilarly these isoenzymes. The degree of sensitivity of various aldehyde dehydrogenase isoenzymes to disulphirame is important for estimation of the drug efficiency.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D004221:Disulfiram / Q000008:administration & dosage / Q000494:pharmacology*; D004343:Drug Implants; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D004343:Drug Implants; D007527:Isoenzymes; D000429:Alcohol Oxidoreductases; D004221:Disulfiram
Al'degiddegidrogenazy pecheni krys pri implantatsii antialkogol'nogo preparata prolongirovannogo deĭstviia.