Central dopaminergic activity influences rats ability to exercise.
Rats were run to exhaustion on a motor driven treadmill. Apomorphine given to intact rats prolonged the time to exhaustion. Apomorphine given to 6-hydroxydopamine lesioned rats also prolonged the time to exhaustion. Intracerebroventricular 6-hydroxydopamine alone reduced the time to exhaustion. Clonidine given to these animals had no effect. We suggest that central dopaminergic activity influences rats ability to exercise.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006892:Hydroxydopamines; D016627:Oxidopamine; D003000:Clonidine; D001058:Apomorphine; D004298:Dopamine