The management of elderly patients with acute lower respiratory tract infections: a comparison of pivampicillin and amoxycillin.
In a randomized trial, the efficacy of pivampicillin (500 mg or 1 g twice daily) was compared with that of amoxycillin (250 mg or 500 mg 3-times daily) in 43 elderly hospitalized patients with bronchopneumonia (32 patients) or an acute exacerbation of chronic bronchitis (11 patients). Overall, 13 (57%) out of the 23 patients taking pivampicillin were cured, and the remaining 10 subjects were improved. In the amoxycillin group, there were 9 (45%) cures, 9 improved and 2 failures of treatment. One patient in each treatment group had mild side-effects. Forty (93%) out of the 43 patients in the study expressed a preference for an antibiotic that was given twice daily as opposed to one where 3 doses were taken each day.
D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D000667:Ampicillin / Q000031:analogs & derivatives*; D001991:Bronchitis / Q000188:drug therapy*; D001996:Bronchopneumonia / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D010917:Pivampicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation
D010917:Pivampicillin; D000667:Ampicillin; D000658:Amoxicillin