Fusidic acid in orthopaedic infections due to coagulase-negative staphylococci.
Twenty orthopaedic in-patients who developed an acute infection due to coagulase-negative staphylococci, and which was associated with a foreign body in 11 cases, were treated with fusidic acid. All patients were given oral medication, except for 1 child with acute osteomyelitis who was treated intravenously for the first 7 days. The mean daily dose was 21 mg/kg and the mean duration of treatment 20 days. Fusidic acid was given alone in 5 patients and concurrently with another antibiotic in the other 15 patients. All patients responded satisfactorily with resolution of the relevant signs and symptoms, although 1 patient relapsed subsequently. Mild side-effects were observed in 3 patients.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001847:Bone Diseases / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003030:Coagulase; D004359:Drug Therapy, Combination; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007223:Infant; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009985:Orthopedics; D010406:Penicillins / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003030:Coagulase; D005839:Gentamicins; D010406:Penicillins; D005672:Fusidic Acid; D008712:Methicillin