Very large and isotypically atypical polyclonal plaque-forming cell responses in mice infected with Trypanosoma cruzi.
Normal C3H/HeJ mice, acutely infected with T. cruzi, develop large numbers of splenic Ig-secreting plaque-forming cells (PFC). IgG2a, IgG2b and IgG1 PFC account for over 90% of all PFC, while the numbers of IgG3- and IgA-secreting PFC are lower than in normal animals. These effects appear to be due to both T helper-dependent regulation and to a mitogenic activity associated with the parasites themselves.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D014355:Chagas Disease / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014349:Trypanosoma cruzi / Q000276:immunology*