[Early changes in GABA and glutamate levels and aminotransferase activity in parts of the rat brain following whole-body gamma irradiation at an absolutely lethal dose].
The contents of gamma-aminobutyric acid (GABA) and glutamate (GL) as well as GABA-aspartate- and alanine aminotransferase activities were measured in rat cerebellum, cerebral cortex and truncus cerebri 1, 3, 6, 24 and 48 hr following total-body gamma-irradiation (60Co) with a dose of 30 Gy. All the indices under study changed in a similar way in the cortex and truncus cerebri while in the cerebellum, GABA level increased and GABA-alpha-ketoglutarate aminotransfearse activity decreased 60 min after irradiation. The levels of GABA and GL in the cortex and truncus cerebri decreased immediately and increased 24 hr after irradiation. Activity of aminotransferases changed in a phase manner: changes in aspartate- and alanine aminotransferase activity were more pronounced than those of GABA-alpha-ketoglutarate aminotransferase activity and correlated with the glutamate level changes.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D005971:Glutamates / Q000528:radiation effects*; D008297:Male; D011829:Radiation Dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D000637:Transaminases / Q000528:radiation effects*; D014916:Whole-Body Irradiation; D005680:gamma-Aminobutyric Acid / Q000528:radiation effects*
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D000637:Transaminases
Rannie izmeneniia urovnia GAMK, glutamata i aminotransferaznoĭ aktivnosti v otdelakh golovnogo mozga krys posle obshchego gamma-oblucheniia v absoliutno letal'noĭ doze.