Clinical trial of nimodipine for single attacks of classic migraine.
In a randomized, double-blind cross-over study, 43 patients with classic migraine received 40 mg Nimodipine and placebo as sublingual capsules. There was no significant effect on patients' preference, development of headache, need for escape medicine, duration of headache, severity of headache or headache index. Considerable methodological problems were encountered. Only 54% of the 79 patients selected for the trial could be evaluated. Suggestions for future trials are made.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy*; D009539:Nicotinic Acids / Q000009:adverse effects / Q000627:therapeutic use*; D009553:Nimodipine; D010352:Patient Dropouts; D011897:Random Allocation; D014665:Vasodilator Agents / Q000627:therapeutic use*
D009539:Nicotinic Acids; D014665:Vasodilator Agents; D009553:Nimodipine