Smooth muscle antibody in children with acute rheumatic fever and rheumatic heart disease.
Smooth muscle antibody (SMA) was positive in 66.7% of children with acute rheumatic fever, in 46.1% of children with chronic rheumatic heart disease, and in only 11.9% of normal Chinese children. These findings indicate that the SMA is one of the bioproducts of acute rheumatic fever and rheumatic heart disease, but the immunopathogenetic role of SMA in these particular disease still needs further investigation.
D000208:Acute Disease; D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D001426:Bacterial Proteins; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D006330:Heart Defects, Congenital / Q000276:immunology; D006801:Humans; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology*; D012213:Rheumatic Fever / Q000276:immunology*; D012214:Rheumatic Heart Disease / Q000276:immunology*; D013301:Streptolysins / Q000276:immunology
D001323:Autoantibodies; D001426:Bacterial Proteins; D013301:Streptolysins; C025964:streptolysin O