Long-term application of wearable artificial endocrine pancreas--closed-loop intravenous vs subcutaneous insulin infusion.
For closed-loop glycemic control on IDDM, closed-loop sc insulin infusion algorithm has developed by analysing the pharmacokinetics of sc insulin absorption. With the algorithm, daily glycemic excursion in IDDMs was controlled to near-normal levels. These data suggested that the closed-loop sc insulin infusion algorithm might be feasible to regulate glycemia in diabetic patients for a long-term period by wearable artificial endocrine pancreas.
D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007279:Injections, Subcutaneous; D007328:Insulin / Q000493:pharmacokinetics; D007332:Insulin Infusion Systems
D001786:Blood Glucose; D007328:Insulin