Neuron-specific enolase and neurofilament protein as markers of differentiation in medulloblastoma.
Immunocytochemical localization of neuron-specific enolase was performed attempting evaluation for neuronal cell differentiation in medulloblastoma. Twenty-seven cases of human medulloblastomas were stained with anti-neuron-specific enolase and antineurofilament protein serum using the peroxidase-antiperoxidase technique. All medulloblastomas showed neuron-specific enolase immunoreaction but only few had neurofilament protein-positive cells. These results suggest that a practically universal tendency towards neuronal cell differentiation occurs in medulloblastomas and that synthesis of neuron-specific enolase takes place before sufficient amounts of neurofilament protein are produced to become immunocytochemically detectable.
D002471:Cell Transformation, Neoplastic / Q000032:analysis / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000032:analysis* / Q000473:pathology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis*; D008527:Medulloblastoma / Q000032:analysis* / Q000473:pathology; D016900:Neurofilament Proteins; D009474:Neurons / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis*
D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins; D010751:Phosphopyruvate Hydratase