Hetero-organic thymus antigens.
The use of sera containing antibodies to tissue-specific antigens of highly specialized organs (skeletal muscles, heart, skin, excretory glands) enabled us to detect, by immunofluorescence, cells capable of synthesizing analogous antigens (i.e. hetero-organic thymus antigens) in human and animal thymus. Detection of hetero-organic antigens in the thymus is the basis for the hypothesis that natural immunological tolerance to tissue self antigens is formed within the thymus in the course of T-lymphocyte maturation, with thymus antigens taking part in the process.
D000328:Adult; D000818:Animals; D002648:Child; D003593:Cytoplasm / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007108:Immune Tolerance; D007781:Lactoferrin / Q000276:immunology; D009157:Myasthenia Gravis / Q000276:immunology; D010392:Pemphigus / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology; D013045:Species Specificity; D013950:Thymus Gland / Q000276:immunology*; D014018:Tissue Distribution
D007781:Lactoferrin