[Autograft of bone marrow following intensive treatment in acute lymphoid leukemia in children].
Ten children were autografted for ALL in second complete remission (CR). The conditioning regimen consisted of cyclophosphamide (60 mg/kg/day X 2) and total body irradiation (10 to 13.2 grays). It was well tolerated, no deaths occurred during the first 3 months post-graft. Nine children remained in second CR, without any maintenance therapy, from 2 to 40 months after ABMT and the median survival time was 11 months. One child died 112 days post-graft, following a cerebral hemorrhage (thrombocytopenia less than 10 X 10(9) platelets/liter). One girl, affected by B ALL, was autografted while in first CR after intensive chemotherapy (modified BACT) 5 months after diagnosis. She relapsed 8 months later. Seven bone marrows have been purged ex vivo by chemotherapy (ASTA-Z) and 3 by anti-CALLA monoclonal antibodies and complement.
D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006410:Hematopoiesis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D008297:Male; D011183:Postoperative Complications; D013997:Time Factors; D014916:Whole-Body Irradiation
D000903:Antibiotics, Antineoplastic; D003520:Cyclophosphamide
L'autogreffe de moelle osseuse au décours de traitements intensifs dans les leucémies aiguës lymphoïdes de l'enfant.