In vivo interactions between the benzodiazepine antagonist Ro 15-1788 and the steroid anaesthetic althesin in rats.
Althesin and delta 16-alphaxalone have been used alone and in combination with the benzodiazepine antagonist Ro 15-1788 to investigate any protective effect these drugs might have against bicuculline-induced convulsions in rats. We found that Althesin provided good protection against bicuculline-induced convulsions which was enhanced when Ro 15-1788 was also present. delta 16-Alphaxalone lacks the anaesthetic properties of Althesin, but did have some activity in preventing bicuculline-induced convulsions, although it was less effective than Althesin. Its action was not enhanced by treatment with Ro 15-1788. Although we have no definitive explanation of these results, it is possible that when Ro 15-1788 is used clinically, it may interact with other drugs not related chemically to the benzodiazepines.
D000530:Alfaxalone Alfadolone Mixture / Q000627:therapeutic use*; D000777:Anesthetics / Q000627:therapeutic use; D000818:Animals; D001570:Benzodiazepinones / Q000627:therapeutic use*; D001640:Bicuculline; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005442:Flumazenil; D011277:Pregnanediones / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000517:prevention & control*
D000777:Anesthetics; D001570:Benzodiazepinones; D011277:Pregnanediones; D005442:Flumazenil; D000530:Alfaxalone Alfadolone Mixture; C006477:alphaxalone; D001640:Bicuculline