Mucociliary transport of human ear secretions in otitis media with effusion.
Rheologically active mucus glycoproteins (mucins) were isolated from the middle ear effusions of 282 patients (344 ears) presenting with secretory otitis media (SOM). The mucins were pooled according to the pathologic condition associated with the SOM. Pools were reconstituted to the same conditions and tested for ciliary transport rates with the use of the frog palate transport model. Mucin obtained from cleft palate patients showed significant differences in transport behavior in comparison with mucins from other groups of patients with SOM.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001692:Biological Transport; D002648:Child; D002675:Child, Preschool; D002923:Cilia / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D009077:Mucins / Q000378:metabolism*; D010033:Otitis Media / Q000378:metabolism*; D010034:Otitis Media with Effusion / Q000378:metabolism*; D010159:Palate / Q000378:metabolism; D011892:Rana catesbeiana; D012212:Rheology
D009077:Mucins