[Pseudomonas aeruginosa toxoid].
P. aeruginosa adsorbed toxoid has been obtained. The stabilization of exotoxins and the content of proteases, hemolysin, lecithinase in their structure have been found to enhance the immunogenic potency of preparations which protect test animals from death caused by the experimental injections of toxins, homologous and heterologous to bacterial strains of different O-serogroups, into these animals. Antibodies neutralizing the lethal action of P. aeruginosa exotoxin have been detected in the blood sera of immunized animals.
D000042:Absorption; D000818:Animals; D000992:Antitoxins / Q000032:analysis; D005098:Exotoxins / Q000032:analysis / Q000633:toxicity; D006168:Guinea Pigs; D006460:Hemolysin Proteins / Q000032:analysis; D007114:Immunization; D007928:Lethal Dose 50; D051379:Mice; D010447:Peptide Hydrolases / Q000032:analysis; D010740:Phospholipases / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000472:pathogenicity; D011817:Rabbits; D014121:Toxoids / Q000032:analysis / Q000276:immunology / Q000302:isolation & purification*
D000992:Antitoxins; D005098:Exotoxins; D006460:Hemolysin Proteins; D014121:Toxoids; D010740:Phospholipases; D010447:Peptide Hydrolases
Toksoid Pseudomonas aeruginosa.