Susceptibility and HLA-B27 in post-dysenteric arthropathies.
A recent outbreak of bacillary dysentery in The Netherlands revealed that, despite the close association of HLA-B27 with post-dysenteric or reactive arthritis (ReA), not even in one family did all HLA-B27 positive patients infected by an arthritogenic bacterium, develop ReA. This dissociation shows that additional factors beside B27 may determine susceptibility to ReA.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D001168:Arthritis / Q000209:etiology / Q000276:immunology*; D004198:Disease Susceptibility; D004405:Dysentery, Bacillary / Q000150:complications*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D000091402:Prohibitins; D012763:Shigella flexneri / Q000276:immunology
D000907:Antibodies, Bacterial; D006680:HLA Antigens; D015796:HLA-B27 Antigen; C000717331:PHB2 protein, human; D000091402:Prohibitins