Uptake of gamma-aminobutyric acid by human blood platelets: comparison with CNS uptake.
Human blood platelets show a sodium and temperature dependent uptake of gamma-aminobutyric acid (GABA) and other neuroactive amino acids. The most potent inhibitors tested of platelet GABA uptake were taurine and beta-alanine, while nipecotic acid and cis-3-aminocyclohexanecarboxylic acid were relatively weak inhibitors. These results suggest GABA is transported by a beta-amino acid uptake process in human platelets. Thus, platelet GABA uptake may more closely resemble glial rather than neuronal uptake.
D000596:Amino Acids / Q000494:pharmacology; D000598:Amino Acids, Cyclic; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D009557:Nipecotic Acids / Q000494:pharmacology; D011392:Proline / Q000031:analogs & derivatives*; D012964:Sodium / Q000494:pharmacology; D013654:Taurine / Q000494:pharmacology; D015091:beta-Alanine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000097:blood* / Q000378:metabolism
D000596:Amino Acids; D000598:Amino Acids, Cyclic; D003509:Cyclohexanecarboxylic Acids; D009557:Nipecotic Acids; D015091:beta-Alanine; D013654:Taurine; C030278:nipecotic acid; C015666:3-aminocyclohexanecarboxylic acid; D005680:gamma-Aminobutyric Acid; D011392:Proline; D012964:Sodium; C010983:homoproline