Protective effect by UCB JO28 against histamine and methacholine induced bronchial hyperreactivity.
UCB JO28 [( 2-[2-[4-(diphenylmethylene)-1-piperidinyl] ethoxy] ethoxy] acetic acid, hydrochloride) is derived from diphenylmethylene piperidine. Animal experiments have shown that it has spasmolytic properties for smooth muscle, particularly in the bronchi, as well as anti-Hl, anticholinergic and anti-serotonin activities. The degree of protection by JO28 against histamine and methacholine-induced bronchospasm has been investigated in 20 asthmatic patients with serious airways hyper-reactivity. Protection against histamine-induced bronchospasm was almost complete in 11 out of 12 patients, whereas protection against methacholine-induced bronchospasm, although clearly present in seven of eight patients, was less marked.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001986:Bronchial Spasm / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006632:Histamine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000009:adverse effects*; D008875:Middle Aged; D010880:Piperidines / Q000097:blood / Q000627:therapeutic use*; D011446:Prospective Studies
D008688:Methacholine Compounds; D010880:Piperidines; D016210:Methacholine Chloride; D006632:Histamine; C046752:UCB JO28