Fenoprofen calcium versus aspirin in the treatment of acute inflammatory soft-tissue injuries.
The efficacy and safety of fenoprofen calcium (Nalfon, Dista, Indianapolis, IN) and aspirin for treating acute inflammatory soft tissue injuries were compared in a 3 to 10-day randomized, double-blind, parallel study of 100 patients with bruise (1), bursitis (33), ligamentous strain (8), myofascitis (43), and tendinitis (15). Forty-seven of the 50 aspirin-treated and 48 of the 50 fenoprofen-treated patients were evaluable. Results of the study showed that fenoprofen calcium and aspirin were equally effective in treating acute inflammatory soft-tissue injuries; however, adverse experiences occurred in fewer patients and at a lower frequency with fenoprofen calcium therapy. In global assessments, 73% of the patients rated fenoprofen therapy as very good or good compared to 64% of the patients who received aspirin therapy. There were no significant differences in the clinician's and the patients' global assessments of therapy. The study suggests that fenoprofen calcium is effective for use in treating soft-tissue injuries since it is better tolerated than aspirin when given in equally effective doses.
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use* / Q000633:toxicity; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005279:Fenoprofen / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D010666:Phenylpropionates / Q000627:therapeutic use*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000503:physiopathology
D010666:Phenylpropionates; D001241:Aspirin; D005279:Fenoprofen