Genesis of lithium-induced T wave flattening.
We studied the effect of oral potassium supplement alone and with spironolactone on the lithium-induced T wave change in rabbits. T wave flattening produced by lithium was not affected by oral potassium supplementation. Oral spironolactone therapy effectively reverted as well as prevented lithium-induced T wave flattening.
D000818:Animals; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D008094:Lithium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016651:Lithium Carbonate; D009206:Myocardium / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D013148:Spironolactone / Q000494:pharmacology
D013148:Spironolactone; D016651:Lithium Carbonate; D011189:Potassium Chloride; D008094:Lithium; D011188:Potassium