Improved patient and graft survival using cyclosporin A in cadaver renal transplantation.
In two consecutive prospective randomised trials cyclosporin A has been compared with conventional immunosuppressive therapy (azathioprine and steroids) and with cyclosporin combined with steroids. The present report is a 4 year review and includes 165 patients.Cyclosporin A alone had a significant advantage over conventional therapy at both 1 and 3 years (p = 0.02) for both patient and graft survival. No significant difference was seen when cyclosporin was combined with steroids. Nephrotoxicity was the most troublesome side-effect of cyclosporin A - but this resolved spontaneously on withdrawal of the drug.
D002102:Cadaver; D002986:Clinical Trials as Topic; D003524:Cyclosporins / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D016030:Kidney Transplantation; D011897:Random Allocation
D003524:Cyclosporins