Studies on healthy contacts of leprosy patients--a preliminary report.
91 healthy contacts of leprosy patients were studied for subclinical infection and possibly the pre-clinical stage of the disease using a battery of tests. It was observed that the test based on competitive inhibition of monoclonal antibody binding to the MY2 a determinant of M. leprae identifies a preclinical stage of the disease.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007916:Lepromin; D007918:Leprosy / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000635:transmission*; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology*; D009297:Nasal Mucosa / Q000473:pathology; D018805:Sepsis
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007916:Lepromin