The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.
Recent clinical observations and psychiatric diagnostic findings of drug-dependent individuals suggest that they are predisposed to addiction because they suffer with painful affect states and related psychiatric disorders. The drugs that addicts select are not chosen randomly. Their drug of choice is the result of an interaction between the psychopharmacologic action of the drug and the dominant painful feelings with which they struggle. Narcotic addicts prefer opiates because of their powerful muting action on the disorganizing and threatening affects of rage and aggression. Cocaine has its appeal because of its ability to relieve distress associated with depression, hypomania, and hyperactivity.
D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D000374:Aggression / Q000187:drug effects; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D002755:Choice Behavior; D003042:Cocaine / Q000494:pharmacology; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D003932:Heroin / Q000494:pharmacology; D006556:Heroin Dependence / Q000209:etiology / Q000523:psychology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D009294:Narcotics / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011574:Psychoanalytic Theory; D011889:Rage / Q000187:drug effects; D012651:Self Medication / Q000523:psychology*
D009294:Narcotics; D003932:Heroin; D003042:Cocaine