Are vascular mechanisms involved in antidepressant action?
Recent studies of the mechanisms of action of certain antidepressants, anti-migraine agents, and Ca2+ entry blockers have been briefly reviewed and analyzed. It is postulated that a thorough explanation of the therapeutic effects of antidepressants should include discussion of their actions on the cardiovascular (cerebrovascular) system. The inhibitory actions of antidepressants on Ca2+- and serotonin (5-HT)-mediated processes of vascular smooth muscle seem to be particularly important.
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002147:Calmodulin / Q000037:antagonists & inhibitors; D002319:Cardiovascular System / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy; D009203:Myocardial Infarction / Q000139:chemically induced; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D002121:Calcium Channel Blockers; D002147:Calmodulin; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists