Association between DR3 and thrombocytopenia due to gold or tiopronin. Case reports and review of the literature.
Two patients who developed thrombocytopenia while on Tiopronin and gold salts respectively were HLA typed. Their common haplotype was A25(10), B8, DR3. A survey of the literature showed that the association between DR3 and the sudden onset form of thrombocytopenia is striking. A genetic predisposition, besides other unknown factors, seems to play a crucial role.
D000603:Amino Acids, Sulfur / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005260:Female; D006046:Gold / Q000009:adverse effects*; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008875:Middle Aged; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D008625:Tiopronin / Q000009:adverse effects*
D000603:Amino Acids, Sulfur; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D006046:Gold; D008625:Tiopronin