[Rearrangement of the chromosome 17 in colonic adenocarcinoma].
Chromosome studies on five cases of large bowel adenocarcinoma show a systematic rearrangement of chromosome No. 17 after breakage in its juxtacentromeric region (band 17 q 11). A frequent involvement of chromosome No. 8 (juxtacentromeric break) and the loss of chromosome No. 18 are also noticed. A review of the literature strengthens the hypothesis of a preferential involvement of these chromosomes in large bowel cancer.
D000230:Adenocarcinoma / Q000235:genetics*; D002503:Centromere / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D003110:Colonic Neoplasms / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008677:Metaphase; D009857:Oncogenes; D012004:Rectal Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D005819:Genetic Markers
Remaniement du chromosome 17 dans l'adénocarcinome colique.