Low rate of NADPH/ADP-iron dependent lipid peroxidation in hepatic microsomes of DBA/2 mice.
Hepatic microsomal lipid peroxidation has been studied in 4 inbred strains of mice: C57BL/6, BALB/c, AKR and DBA/2. The rates of lipid peroxidation stimulated in vitro by carbon tetrachloride, ascorbate-iron and cumene hydroperoxide were similar in all 4 strains. Lipid peroxidation induced by NADPH/ADP-iron, however, proceeded at a substantially lower rate in the hepatic microsomes of DBA/2 mice. It is suggested that this low rate of enzymic iron-induced lipid peroxidation is a factor that may be involved in the resistance of this strain of mice to experimental hepatic porphyria induced by polyhalogenated aromatic hydrocarbons.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA / Q000378:metabolism*; D008815:Mice, Inbred Strains / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism
D005227:Fatty Acids; D008054:Lipid Peroxides; D009249:NADP; D000244:Adenosine Diphosphate; D003577:Cytochrome P-450 Enzyme System; D007501:Iron; D009251:NADPH-Ferrihemoprotein Reductase