The effect of a range of antimicrobial drugs on the haemagglutination of two clinical isolates from urinary tract infections.
A range of nine common antimicrobial drugs were tested for their effect on adhesion of the mannose-resistant haemagglutination-positive Proteus vulgaris strain BH77 and Escherichia coli strain BH121, isolated from patients with urinary tract infections. Minimum inhibitory concentrations of the antimicrobials for these strains were determined in Mueller-Hinton broth and the effect of each antimicrobial, at the quarter MIC values, on the haemagglutination of the strains was then determined. Haemagglutination could only be prevented by inhibitors of protein synthesis. After the introduction of an R-plasmid into strain BH121 this effect was annihilated. When the new MICs were determined, the inhibition was still observed at the new quarter MIC values.
D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006386:Hemagglutination Tests; D006801:Humans; D008826:Microbial Sensitivity Tests; D011514:Proteus vulgaris / Q000187:drug effects*; D014552:Urinary Tract Infections / Q000382:microbiology*
D000892:Anti-Infective Agents, Urinary