[Stability of 8 second or third generation cephalosporins in peritoneal dialysis fluid].
The main complication of chronic ambulatory peritoneal dialysis is peritoneal infection due to contamination while handling dialysate bags. For this reason antibiotics should be added to the dialysate to prevent infection. Some antibiotics are known to be unstable when dissolved in dialysate. We therefore studied the bactericidal activity of eight second or third generation cephalosporins against Escherichia coli and Staphylococcus aureus under conditions similar to in vivo situations. Comparison of killing curves shows that bactericidal activity is unchanged after 24 hours in the dialysis fluid at room temperature.
D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects*
D002511:Cephalosporins; D012996:Solutions
Etude de la stabilité de huit céphalosporines de deuxième et troisième générations dans le liquide de dialyse péritonéale.