A stable isosterically modified prostacyclin analogue, FCE-22176, acting as a competitive antagonist to prostacyclin in guinea-pig trachea and atria.
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D013237:Stereoisomerism; D014132:Trachea / Q000378:metabolism
C039192:13,14-didehydro-20-methylcarboprostacyclin; D006632:Histamine; D011464:Epoprostenol