B-cell subsets: functional and structural characteristics.
The review will examine B-cell differentiation with an emphasis on B-cell subpopulations. We will begin with an analysis of current evidence concerning B-cell ontogeny. The development of the B-cell repertoire will be traced from stem cell to effector cells. The CBA/N mouse, which expresses an X-linked immunodeficiency, will serve as a basis for discussing the delineation of B cells into subpopulations. The CBA/N mouse provides evidence for distinct populations of B cells which can be differentiated by cell surface antigens as well as function. We intend to focus on the functional diversity of B-cell subpopulations and how they develop. The CBA/N mouse is not the only evidence for distinct B cell subpopulations and we will attempt to organize these data into a coherent story of B-cell subsets.
D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D007154:Immune System Diseases / Q000235:genetics; D007074:Immunoglobulin G; D051379:Mice; D008808:Mice, Inbred CBA; D009928:Organ Specificity; D051381:Rats; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012729:Sex Chromosome Aberrations; D013601:T-Lymphocytes / Q000276:immunology; D014960:X Chromosome
D000906:Antibodies; D000954:Antigens, Surface; D007074:Immunoglobulin G; D011947:Receptors, Antigen, B-Cell