[Immunohistochemical determination of estrogen receptors in breast carcinoma tissue using monoclonal antibodies. 1st clinical findings].
The results of preliminary investigations into specific immunohistochemical detection of the estrogen receptor in breast cancer tissue by means of monoclonal antibodies are presented. Thirty-one tumor tissue samples stored in a tumor tissue bank for between 10 and 35 months were immunohistochemically studied. The comparison between the immunohistochemical result and the result of the biochemical estrogen receptor assay show a large measure of agreement (90%). The comparison of the results with regard to response to endocrine therapy in cases of metastatization shows that immunohistochemical detection furnishes at least as much information as the dextran-coated charcoal method.
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000032:analysis* / Q000188:drug therapy; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*
D000911:Antibodies, Monoclonal; D006728:Hormones; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
Immunhistochemische Bestimmung von Ostrogenrezeptoren in Mammakarzinomgeweben mittels monoclonaler Antikörper. Erste klinische Ergebnisse.