[Effect of gossypol on spermatogenesis and fertility in man and mammals].
This review summarizes the main results of experimental and clinical studies of a new antifertile agent, gossypol, a polyphenolic compound isolated from the cotton. This compound disturb the normal course of spermatogenesis and affects, first of all, the locomotory system of mature spermatozoa of the man and some mammal species. The mechanism of gossypol action on the development of germ cells is discussed. Since the action of gossypol is reversible and it does not induce strong side effects, the possibility of its application for the control of birth rate is considered.
D000176:Acrosin / Q000037:antagonists & inhibitors; D000728:Androgens / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D003272:Contraceptive Agents, Male; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004622:Embryo, Mammalian / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D005796:Genes / Q000187:drug effects; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D006072:Gossypol / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D013045:Species Specificity; D013089:Spermatocidal Agents; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology
D000728:Androgens; D003272:Contraceptive Agents, Male; D006065:Gonadotropins, Pituitary; D007527:Isoenzymes; D013089:Spermatocidal Agents; D007770:L-Lactate Dehydrogenase; D000176:Acrosin; D006072:Gossypol
Deĭstvie gossipola na spermatogenez i fertil'nost' cheloveka i mlekopitauishchikh zhivotnykh.