[Recurrence of chronic duodenal ulcer following initial therapy with pirenzepine or cimetidine].
Recurrence rates of chronic duodenal ulcer after initial therapy with pirenzepine or cimetidine were investigated in a prospective, randomized trial with a total of 80 patients. After 12 weeks of therapy with pirenzepine (50 mg b.i.d) or cimetidine (200 mg t.i.d. + 400 mg nocte) 68,7% and 88,5% respectively were healed (chi 2 = 3,97; p less than 0,05). These patients showed recurrences in 73,6% after pirenzepine and in 84,6% after cimetidine during a six months observation period. This difference is not statistically significant, nor was life table analysis capable to show any difference in the relapse pattern between the two groups.
D000328:Adult; D000368:Aged; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002908:Chronic Disease; D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010890:Pirenzepine; D012008:Recurrence; D014945:Wound Healing / Q000187:drug effects
D001570:Benzodiazepinones; D010890:Pirenzepine; D002927:Cimetidine
Rezidive des chronischen Ulcus duodeni nach initialer Therapie mit Pirenzepin oder Cimetidin.