Antigen-induced suppression: the role of class I major histocompatibility antigens.
The role of Class I major histocompatibility (MHC) antigens in the induction of specific suppression of graft rejection has been investigated. Two experimental transplantation models have been used - fully vascularized heterotopic cardiac allografts in the mouse and fully vascularized orthotopic renal allografts in the rat. Preparations of cells expressing Class I MHC antigens, for example highly purified preparations of rat erythrocytes or platelets or mouse L cells (H2k) transfected with the D locus Class I gene of the b haplotype, LDb-1 cells, were used to pretreat recipients prior to transplantation. The function of the allograft was monitored in order to assess any beneficial effects induced by Class I MHC antigens. The results obtained implicate Class I MHC as important in the induction of specific immunosuppression of vascularized allograft rejection.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D003326:Coronary Circulation; D006084:Graft Rejection; D016027:Heart Transplantation; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D012079:Renal Circulation; D013045:Species Specificity; D014184:Transplantation, Homologous
D000941:Antigens