[Erythema migrans borreliosis in the Federal Republic of Germany. Epidemiology and clinical aspects].
A positive antibody titre against Ixodes-ricinus-Borrelia (burgdorferi), using indirect immunofluorescence or ELISA, could be detected in serum and (or) liquor of 935 (32%) out of a total of 2955 patients between January 1984 and July 1985. In 289 of these cases the typical clinical manifestations were lacking whereas a characteristic disease picture enabled a diagnosis to be made in 171 patients with negative or borderline antibody titres. The 1106 cases of infection observed covered all regions of the country. A typical clinical syndrome was seen in 817 (74%) of these. Most common were erythema chronicum migrans (n = 458) and meningopolyneuritis Garin-Bujadoux-Bannwarth (n = 404); in 42% of the cases meningopolyneuritis was preceded by an erythema. Arthritis (n = 63), acrodermatitis chronica atrophicans (n = 72), carditis (n = 13) and lymphadenosis benigna cutis (n = 5) were much less common. Chronic Borrelian encephalomyelitis (n = 45) appeared surprisingly often (n = 45). The fact that in 73% of cases the various syndromes appeared alone, were double in 24% and combined only in 3%, illustrates the polymorphic nature of this disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001898:Borrelia / Q000276:immunology; D001899:Borrelia Infections / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D004679:Encephalomyelitis / Q000209:etiology; D004797:Enzyme-Linked Immunosorbent Assay; D004890:Erythema / Q000209:etiology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005860:Germany, West; D006801:Humans; D008297:Male; D008581:Meningitis / Q000209:etiology; D008875:Middle Aged; D011115:Polyneuropathies / Q000209:etiology; D013577:Syndrome
D000907:Antibodies, Bacterial
Erythema-migrans-Borreliose in der Bundesrepublik Deutschland. Epidemiologie und klinisches Bild.