Reactions of the semiquinone free radicals of anti-tumour agents with oxygen and iron complexes.
The rates of reaction of the semiquinone radicals of adriamycin and mitomycin C with oxygen and several iron (III) complexes have been determined. These rates have been used to explain enhanced free radical damage produced by semiquinone radicals in a model system and to assess the feasibility of these types of reactions occurring in hypoxic cells.
D016227:Benzoquinones; D055598:Chemical Phenomena; D002621:Chemistry; D004317:Doxorubicin / Q000378:metabolism*; D005290:Ferric Compounds / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D016685:Mitomycin; D008937:Mitomycins / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011809:Quinones / Q000378:metabolism*
D016227:Benzoquinones; D005290:Ferric Compounds; D008937:Mitomycins; D011809:Quinones; C025232:semiquinone radicals; D016685:Mitomycin; D004317:Doxorubicin; D007501:Iron; D010100:Oxygen