[Vitamin C in a long-term trial is without effect on experimental carcinogenesis].
This long-term study deals with the effect of ascorbic acid on chemically induced carcinogenesis of the small intestine in rats. Carcinoma was induced in 27 animals by application of N-Ethyl-N'-nitro-N-nitrosoguanidine (ENNG) alone in the drinking water (120 mg/1). The average survival time was 238 ( 40) days. The addition of large amounts of ascorbic acid to the food (3 g/100 g food) did not suppress the development of tumors. On the contrary, a significant reduction in the survival time was seen. All animals receiving ENNG and ascorbic acid only lived 207 ( 45) days on average. Neither histological type of tumor spread was influenced by the use of ascorbic acid. Giving ascorbic acid alone had no effect on the survival time and did not lead to changes in the tissue of the small intestine.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002273:Carcinogens; D004064:Digestive System / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007417:Intestinal Polyps / Q000139:chemically induced; D008134:Long-Term Care; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; C013525:ENNG; D001205:Ascorbic Acid
Vitamin C im Langzeitversuch ohne Einfluss auf die experimentelle Carcinogenese.