[Acute amiodarone poisoning. Clinical and pharmacokinetic study].
A 73 years old patient, treated with Amiodarone for ventricular tachycardia, ingested 6 000 mg of Amiodarone. This did not induce hemodynamic troubles or aggravation of ventricular arrhythmia. Treatment included a gastric lavage and purging at the third hour. Plasma assay revealed a concentration of 3.69 mg/l at the fourth hour. Their evolution can be described as the sum of two exponentials. The half-life of the first exponential is 4.9 hours ; the half-life of the second one is 544 hours. Amiodarone is an antiarrhythmic agent of high safety.
D000368:Aged; D000638:Amiodarone / Q000378:metabolism / Q000506:poisoning*; D001572:Benzofurans / Q000506:poisoning*; D005260:Female; D006801:Humans; D007700:Kinetics
D001572:Benzofurans; D000638:Amiodarone
Intoxication aiguë à l'amiodarone. Etude clinique et pharmacocinétique.