[Lack of effect of aging on dopaminergic inhibition of aldosterone and prolactin increase].
Because of the decreased dopamine concentration in the elderly brain an alteration of the dopaminergic suppression of aldosterone and prolactin incretion was postulated. In contrast, the application of the dopamine D2-antagonist metoclopramide showed no significant difference as to the blockade of this dopaminergic suppression in two groups of patients with a mean age of 40 and 80 years. Subsequently aldosterone and prolactin incretion was equally stimulated in both groups.
D000328:Adult; D000368:Aged; D000375:Aging; D000450:Aldosterone / Q000097:blood*; D001921:Brain / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008787:Metoclopramide / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects; D011388:Prolactin / Q000097:blood*; D012083:Renin / Q000097:blood
D000450:Aldosterone; D011388:Prolactin; D012083:Renin; D008787:Metoclopramide; D004298:Dopamine; D006854:Hydrocortisone
Fehlender Einfluss des Alters auf die dopaminerge Inhibierung der Aldosteron- und Prolaktininkretion.