Effect of ambroxol on human phagocytic cell function.
The in vitro effects of ambroxol on phagocytic and microbicidal activities of human neutrophils and monocytes have been studied. Preincubation of neutrophils with ambroxol (10 to 100 ng/ml) had no effect on their phagocytic or microbicidal capacities. On the other hand, when monocytes were preincubated for 24 hours with ambroxol a significant increase of their microbicidal activity was observed, without effect on the phagocytic properties.
D000551:Ambroxol / Q000494:pharmacology*; D001964:Bromhexine / Q000031:analogs & derivatives*; D002176:Candida albicans; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D013997:Time Factors
D000551:Ambroxol; D001964:Bromhexine