The moyamoya syndrome associated with irradiation of an optic glioma in children: report of two cases and review of the literature.
We report two cases of the moyamoya syndrome which became clinically apparent after irradiation of an optic glioma during childhood. A summary of 14 cases of this syndrome following irradiation of intracranial tumors is also presented. Nine of these cases were optic gliomas; five were found in children with neurofibromatosis, another disorder that has a strong association with the moyamoya syndrome. The effectiveness of irradiation of optic gliomas in childhood is not definitely established. The possibility of inducing serious vascular disease is a further reason for caution when considering irradiating these tumors.
D001157:Arterial Occlusive Diseases / Q000209:etiology*; D002536:Cerebral Arteries / Q000528:radiation effects*; D003390:Cranial Nerve Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D009072:Moyamoya Disease / Q000209:etiology*; D009901:Optic Nerve Diseases / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology*