Immunogenicity and immunosensitivity of a guinea pig B-cell leukemia subline lacking cell surface Ia antigens.
L2C is a transplantable B-cell leukemia of strain 2 guinea pigs. Transplantation protection experiments were performed with L2C sublines expressing or lacking cell surface antigens coded for by the I region of the major histocompatibility complex (Ia). A subline (BZ-L2C) that lacked cell surface Ia antigens was immunogenic but relatively resistant to immunological attack. The data suggest that rejection of this B-cell leukemia may be influenced by expression of cell surface Ia antigens.
D000818:Animals; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D003877:Dermatitis, Contact; D005260:Female; D005434:Flow Cytometry; D005802:Genes, MHC Class II; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007942:Leukemia, Experimental / Q000276:immunology* / Q000473:pathology; D008297:Male; D009154:Mutation
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II