[Antiherpetic activity of xylure].
In vivo experiments demonstrated antiherpetic activity of abnormal nucleoside, 5-trimethylsylil-2'-deoxyuridine alpha-anomer. In a model of herpetic encephalitis in cotton rats the preparation, inoculated intraperitoneally and administered orally, reduced the lethality by 25%-30% as compared with the controls, and also was effective in topical treatment of genital herpes in guinea pigs. Low toxicity, clear-cut antiherpetic activity, favourable metabolic properties as compared with known antiherpetic drugs indicate the necessity of further thorough investigation of this preparation.
D000212:Acyclovir / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003411:Arvicolinae; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002642:Chick Embryo; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy*; D008590:Meningoencephalitis / Q000188:drug therapy
D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine; D000212:Acyclovir
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