High resolution ultrasound of macro-orchidism in mental retardation.
Asymptomatic testicular enlargement is common in mentally retarded males. This enlargement includes males with non-specific forms of mental retardation as well as a subgroup of males who have a chromosomally recognizable feature involving the X-chromosome ("fragile X" chromosome). We examined the testes of a group of 25 mentally retarded males with macro-orchidism including both fragile X and non-fragile X patients. Apart from large size, the testes scanned were all normal in appearance. In particular, there was no evidence for neoplasia. There were no distinguishing features between the fragile X and the non-fragile X groups.
D005069:Evaluation Studies as Topic; D005600:Fragile X Syndrome / Q000150:complications; D006801:Humans; D006984:Hypertrophy; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D013737:Testis / Q000473:pathology*; D014463:Ultrasonography