Chemotoxicity of indium-111 oxine in mammalian cells.
We have studied the uptake and toxicity of [111In]oxine in Chinese hamster V79 lung fibroblasts. The incorporation of the radionuclide into these cells reached a plateau within 2 hr. Uptake was proportional to the extracellular radioactive concentration. Both radioactive and "decayed" [111In]oxine exhibited similar toxicities, indicating that the observed toxicity was chemical in nature. These results are discussed in terms of the present status of this radiolabeling agent.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D006912:Hydroxyquinolines / Q000633:toxicity*; D007204:Indium / Q000633:toxicity*; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000633:toxicity*; D011868:Radioisotopes
D006912:Hydroxyquinolines; D009942:Organometallic Compounds; D011868:Radioisotopes; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline