Proteolytic and beta-glucuronidase activity in adjuvant arthritis during the ibuprofen therapy.
Antiinflammatory effect of ibuprofen was studied in the model of adjuvant arthritis in rats. Its effectiveness was evaluated on the basis of morphological and biochemical indices. The values of proteolytic and beta-glucuronidase activity in the blood serum were shown to correlate well with clinical exacerbation of adjuvant disease. Both enzymes, especially the beta-glucuronidase activity appeared to be the indices of particular value.
D000818:Animals; D001168:Arthritis / Q000201:enzymology*; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000201:enzymology*; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D007052:Ibuprofen / Q000627:therapeutic use*; D007700:Kinetics; D008297:Male; D010447:Peptide Hydrolases / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005966:Glucuronidase; D010447:Peptide Hydrolases; D007052:Ibuprofen