Intravenous immune globulin therapy. Treatment of a patient with severe immunodeficiency, chronic malabsorption, and fulminant septicemia.
Biweekly 200 mg/kg infusions of immune globulin (Gamimune) were given to a 46-year-old woman with severe common variable immunodeficiency, bronchiectasis, and chronic diarrhea with malabsorption. Failure to achieve therapeutically effective serum IgG concentrations in the face of fulminant sepsis was accompanied by a shortened serum IgG half-life of 10.6 days. Currently recommended doses of 200 mg/kg may prove inadequate in very ill patients with sepsis and malabsorption.
D000361:Agammaglobulinemia / Q000628:therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D016756:Immunoglobulins, Intravenous; D007263:Infusions, Parenteral; D008286:Malabsorption Syndromes / Q000628:therapy*; D008875:Middle Aged; D012008:Recurrence; D018805:Sepsis / Q000188:drug therapy / Q000628:therapy*
D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous