Degradation of human fibronectin by metalloproteases of Serratia marcescens.
The purified metalloproteases of Serratia marcescens strains SF 178 and SH 186 attacked soluble human serum fibronectin. This observation points to a novel mechanism through which bacterial 'aggressins' might abolish nonspecific host defense mechanisms.
D010450:Endopeptidases / Q000378:metabolism*; D005343:Fibrinolytic Agents / Q000378:metabolism*; D005353:Fibronectins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008666:Metalloendopeptidases; D011489:Protein Denaturation; D012706:Serratia marcescens / Q000201:enzymology*
D005343:Fibrinolytic Agents; D005353:Fibronectins; D010450:Endopeptidases; D008666:Metalloendopeptidases