Escherichia coli thymine auxotrophs suppressible by carbon dioxide.
Two independently-isolated thymine-requiring mutant strains of Escherichia coli were found to possess an unusual phenotype: in the presence of CO2, growth was independent of thymine. The two strains showed different profiles of temperature sensitivity. Glycine, serine and methionine were unable to relieve the thymine-dependence. Both strains were susceptible to trimethoprim under conditions where they were thymine-independent. The results are consistent with the occurrence of partial defects in thymidylate synthase.
D002245:Carbon Dioxide / Q000494:pharmacology*; D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D009154:Mutation; D010641:Phenotype; D013941:Thymine / Q000378:metabolism*; D014295:Trimethoprim / Q000494:pharmacology
D002245:Carbon Dioxide; D014295:Trimethoprim; D013941:Thymine