The role of blood platelet and fibrinogen in experimental metastasis in nude mice following whole body X-irradiation.
Human tumor cells were injected intravenously into nude mice following whole body X-irradiation and the number of platelets and the serum fibrinogen level in the blood were examined. Pulmonary metastasis was present in the irradiated mice but not in the non-irradiated mice. The number of platelets decreased rapidly after intravenous injection of the tumor cells and remained low in the irradiated mice, yet there was a recovery in the number in the non-irradiated mice. Serum fibrinogen level was increased in the irradiated mice and was decreased after intravenous injection in the irradiated mice, to a greater extent than seen in the non-irradiated mice. These findings may be related to trapping and lodgement of tumor cells in the target organ.
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009362:Neoplasm Metastasis / Q000209:etiology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced; D010976:Platelet Count; D014916:Whole-Body Irradiation
D005340:Fibrinogen