[Pharmacokinetic study of pefloxacin in 37 hospital patients under resuscitation].
Pharmacokinetics of pefloxacin were studied in thirty-seven intensive care patients. Fluorimetric assay was used for determining pefloxacin concentrations. Serum concentrations were usually far above threshold levels; however, wide variations across patients were evidenced, with no demonstrable relation to physiologic status. For this reason, pefloxacin assay is useful in high risk patients to avoid subconcentrations.
D006801:Humans; D007362:Intensive Care Units; D007700:Kinetics; D008581:Meningitis / Q000188:drug therapy; D009643:Norfloxacin / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D015366:Pefloxacin; D011014:Pneumonia / Q000188:drug therapy; D012306:Risk; D018805:Sepsis / Q000188:drug therapy
D015366:Pefloxacin; D009643:Norfloxacin
Etude pharmacocinétique de la péfloxacine chez trente-sept malades hospitalisés en réanimation.