The role of diet in animal models of systemic lupus erythematosus: possible implications for human lupus.
Studies of diet in the mouse model of SLE have established the beneficial effects of a low calorie, low fat diet in these animals as well as the importance of the specific source of dietary fat. The role of zinc in murine and human SLE is less clear. The reported improvement of patients with SLE and other related diseases on a low phenylalanine and tyrosine diet high in fish content, and the lupus inducing capacity of a nonphysiologic amino acid present in alfalfa are also reviewed. The need for carefully controlled prospective studies of diet in patients with SLE is noted, and a diet of potential therapeutic benefit is described.
D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects; D004044:Dietary Proteins / Q000502:physiology; D002149:Energy Intake; D005228:Fatty Acids, Essential / Q000172:deficiency; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000178:diet therapy / Q000503:physiopathology*; D008297:Male; D008563:Membrane Lipids / Q000502:physiology; D051379:Mice; D008814:Mice, Inbred NZB; D015032:Zinc / Q000502:physiology
D004041:Dietary Fats; D004044:Dietary Proteins; D005228:Fatty Acids, Essential; D008563:Membrane Lipids; D015032:Zinc