Long-acting penicillins: historical perspectives.
For the more than three decades since benzathine penicillin G was discovered it remains unique as the only antibiotic formulation that can provide serum drug concentrations for several weeks following a single intramuscular injection. Benzathine penicillin G has withstood the test of time as the ideal drug to treat early, infectious syphilis and to prevent and treat Group A streptococcal infections. It has proved to be extraordinarily effective for the prevention of rheumatic fever recurrences and is a major reason for the marked reduction in the morbidity and mortality in countries where carefully monitored prophylaxis programs have been established.
D000284:Administration, Oral; D000328:Adult; D002648:Child; D006069:Gonorrhea / Q000188:drug therapy; D049673:History, 20th Century; D006801:Humans; D007231:Infant, Newborn; D010400:Penicillin G / Q000266:history*; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000097:blood / Q000266:history*; D010406:Penicillins / Q000008:administration & dosage / Q000097:blood; D010612:Pharyngitis / Q000188:drug therapy; D012008:Recurrence; D012213:Rheumatic Fever / Q000517:prevention & control; D013290:Streptococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D013297:Streptococcus pyogenes / Q000187:drug effects; D013449:Sulfonamides / Q000008:administration & dosage; D013587:Syphilis / Q000188:drug therapy; D013590:Syphilis, Congenital / Q000188:drug therapy
D010406:Penicillins; D013449:Sulfonamides; D010400:Penicillin G; D010401:Penicillin G Benzathine