Fosfomycin-resistance plasmids determine an intracellular modification of fosfomycin.
Escherichia coli cells carrying fosfomycin-resistance plasmids modify fosfomycin intracellularly. The product of this modification (fosfomycin-derivative) differs from fosfomycin in chromatographic mobility, but the chemical nature of the modification is not yet known. Fosfomycin-derivative appears to have a cytoplasmic location and lacks antibiotic activity. The modification system can be saturated by an excess of fosfomycin in the incubation media.
D001692:Biological Transport; D002854:Chromatography, Paper; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005578:Fosfomycin / Q000378:metabolism*; D007700:Kinetics; D011815:R Factors
D005578:Fosfomycin