Cyclosporine and graft failure following bone marrow transplantation for severe aplastic anaemia.
Thirty-nine patients with severe aplastic anaemia were transplanted from HLA identical sibling donors. Irradiation was not used in the pre-transplant immunosuppressive protocol and cyclosporine was used as the post graft immunosuppressive agent. The incidence of primary graft failure (no take) was low occurring in 3/38 evaluable patients. Late graft failure 4-7.5 months post BMT occurred in five patients and was associated with withdrawal of cyclosporine therapy. Mixed lymphocyte chimaerism was demonstrated in 3/5 cases at the time of late graft failure and subsequent marrow recovery was autologous in four patients. Mortality from graft failure was low with 2/38 evaluable patients (5%) dying from this complication.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D008297:Male; D013997:Time Factors; D014185:Transplantation, Isogeneic
D003524:Cyclosporins