Evaluation of genetic damage induced by 8-ethoxycaffeine in Drosophila melanogaster.
The methylated oxypurine, 8-ethoxycaffeine (EOC), was tested for the induction of genetic damage in Drosophila melanogaster. Sex-linked recessive lethals, sex-chromosome loss and tanslocation induction were studied following treatment of adult males, using a feeding technique. Our results show that EOC induces sex-chromosome loss and translocations between the second and third chromosomes, but is unable to induce point mutations in male germ cells under our conditions of testing.
D000818:Animals; D002110:Caffeine / Q000031:analogs & derivatives* / Q000633:toxicity; D004331:Drosophila melanogaster / Q000235:genetics; D005804:Genes, Lethal; D008297:Male; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D012729:Sex Chromosome Aberrations / Q000139:chemically induced; D014178:Translocation, Genetic / Q000187:drug effects*
C020899:8-ethoxycaffeine; D002110:Caffeine