Isolation and characterization of bulgecins, new bacterial metabolites with bulge-inducing activity.
Bulgecins A, B and C, new bacterial metabolites which induce the formation of bulges by cooperation with beta-lactam antibiotics, were isolated from the culture broth of Pseudomonas mesoacidophila. The three components, separated by column chromatography on QAE-Sephadex A-25, are water-soluble acidic compounds containing a sulfate group in the molecule. Acid hydrolysis showed that D-glucosamine and a new proline derivative are common constituents of the three components. In addition, taurine and beta-alanine are constituents of bulgecins A and B, respectively.
D005944:Glucosamine / Q000032:analysis; D006020:Glycopeptides / Q000302:isolation & purification*; D006868:Hydrolysis; D011392:Proline / Q000031:analogs & derivatives / Q000032:analysis; D011549:Pseudomonas / Q000032:analysis*; D012995:Solubility; D013057:Spectrum Analysis; D015091:beta-Alanine / Q000032:analysis
D006020:Glycopeptides; D015091:beta-Alanine; C036713:bulgecin; D011392:Proline; D005944:Glucosamine