Dose response to fenoprofen calcium using placebo and codeine as controls.
This paper evaluates the dose-response relationship of several doses of fenoprofen calcium, between 12.5 and 300 mg, and their relationship to 60 mg of codeine sulfate and placebo. Three separate parallel studies are included in this evaluation, including a total of 867 patients. The types of pain were cesarean section, episiotomy wound, uterine cramping, and general surgery. This paper shows that a significant increasing relationship exists between efficacy and dose of fenoprofen, suggesting that relatively larger doses of fenoprofen will achieve greater amounts of efficacy.
D002585:Cesarean Section; D002986:Clinical Trials as Topic; D003061:Codeine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005279:Fenoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007743:Labor, Obstetric; D010146:Pain / Q000188:drug therapy*; D010149:Postoperative Pain / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D010919:Placebos; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy* / Q000503:physiopathology
D010666:Phenylpropionates; D010919:Placebos; D005279:Fenoprofen; D003061:Codeine