Urinary sodium excretion and the renin-aldosterone system in new-born calves.
Urinary Na+ and K+ excretion, plasma aldosterone levels (PAL) and plasma renin activity (PRA) were measured in three groups of four 3-day-old calves infused with aldosterone, ethacrynic acid and hydrochlorothiazide or with vehicle. Aldosterone infusion (16.7 micrograms/kg body wt. given by rapid injection, followed by the infusion of 33.3 micrograms/kg body wt. during 6 h) decreased urinary Na+ concentration and excretion during the 6 h period of infusion. This effect disappeared during the following 18 h. Ethacrynic acid (2 mg/kg body wt. by rapid injection, followed by the infusion of 1.5 mg/kg body wt..h during 6 h) and hydrochlorothiazide (8 mg/kg body wt. by rapid injection, followed by the infusion of 6 mg/kg body wt..h during 6 h) increased urinary volume and urinary excretion of Na+, but decreased urinary K+ concentration without affecting urinary K+ excretion during the 6 h period of infusion. During the same time, the plasma Na+ concentration decreased, PRA increased rapidly and was followed by a significant rise in PAL. These results demonstrate that in very young healthy calves, the renal tubules are able to respond to aldosterone. The renin-aldosterone system is also operative in these animals since it responds to Na+ depletion induced by the combination of diuretics and inhibitors of tubular Na+ reabsorption.
D000450:Aldosterone / Q000097:blood / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002417:Cattle / Q000502:physiology*; D004976:Ethacrynic Acid / Q000494:pharmacology; D006400:Hematocrit; D006852:Hydrochlorothiazide / Q000494:pharmacology; D007668:Kidney / Q000502:physiology*; D008297:Male; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000652:urine*
D006852:Hydrochlorothiazide; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D004976:Ethacrynic Acid; D011188:Potassium