Some experimental and methodological experiences on the selective inhibition of blood microcirculation in tumor tissues as the central mechanism of the cancer multistep therapy (CMT).
Microcirculation is a very sensitive process. Under hyperthermia and/or artificial tissue acidification bloodflow ceased regularly and reproducibly. This bloodflow inhibition imposes seemingly as a consequence of a progressing decrease of blood fluidity. However, blood flowing through irritated vessels is subjected to local heat and acidic milieu only for few seconds, whereas the vessels of the respective area are exposed to these conditions as long as they continue. Hence, it is important to look for lesions of the vessels, particularly for enhanced porosity.--Using light-conducting electrodes we have studied the perivascular glucose concentrations and the influence of oxygen deficiency on microvessels in vivo. In contrast to our expectation, we have failed to detect endothelial cell swelling. On the other hand, we could observe diminished blood fluidity under anaerobic conditions by use of a simple method with filterpaper strips.--In our tumor studies we achieved reproducibly microcirculation inhibition of about 95% in DS carcinosarcomas as compared to muscle by combining hyperglycemia with hyperthermia (100 min at 43 C degrees). Each of these measures applied alone resulted only exceptionally in an approximately comparable effect. For therapeutic purposes the combination of both seems to us the method of choice.--Controlled hypotension, which can be adjusted extremely well by NAD, caused blood flow inhibition selectively in the tumors.--The remarkable bloodflow inhibition in tumors is achievable in principle also in human tumors.
D000818:Animals; D001786:Blood Glucose / Q000502:physiology; D002296:Carcinosarcoma / Q000098:blood supply* / Q000628:therapy; D003131:Combined Modality Therapy; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008297:Male; D008833:Microcirculation; D051381:Rats
D001786:Blood Glucose