[Virus-associated chronic autoimmune aggressive hepatitis (HBsAg seronegative) with pronounced diarrhea].
It is reported on a 17-year-old male patient who in 1982 fell ill with a HBsAg-seronegative hepatitis with therapy-resistant diarrhoeas of high frequency and in whom immunohistologically a virus-associated autoimmune chronic aggressive hepatitis was established. As cause of severe diarrhoeas which underwent involution only after 2 months as a sequel of the azathioprin-prednisolone therapy the proof of HBsAg in Lieberkühn's crypts of the small intestine performed by means of direct immunofluorescence is assumed.
D000293:Adolescent; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy; D003165:Complement System Proteins / Q000378:metabolism; D003967:Diarrhea / Q000473:pathology*; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000473:pathology; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006521:Hepatitis, Chronic / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007413:Intestinal Mucosa / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011239:Prednisolone / Q000627:therapeutic use
D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins; D011239:Prednisolone; D001379:Azathioprine
Virusassoziierte autoimmune chronisch-aggressive Hepatitis (HBsAg-seronegativ) mit ausgeprägten Diarrhoen.