Combined action of carbaryl and phenthoate on tissue lipid derivatives of murrel, Channa punctatus (Bloch).
The levels of total lipids, free fatty acids, cholesterol, and lipase activity were studied in selected tissues of Channa punctatus Bloch during individual and combined exposures of carbaryl and phenthoate. The total lipid levels decreased with elevated levels of free fatty acids and lipase activity during all exposures, suggesting increased lipid hydrolysis to derive energy as an attempt to face the pesticide toxic stress. The cholesterol levels showed an elevated trend. These results were discussed in relation to induced glyconeogenesis and diversion of acetyl-coA to cholesterol synthesis during pesticide treatment. The effect produced by carbaryl + phenthoate treatment remained higher than either of the pesticides alone, suggesting the manifestation of an additive effect.
D000818:Animals; D012721:Carbaryl / Q000494:pharmacology*; D004357:Drug Synergism; D005399:Fishes / Q000378:metabolism*; D005880:Gills / Q000378:metabolism; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D008049:Lipase; C008838:phenthoate; D012721:Carbaryl