[Novel N-pyrazolylsalicylamides with antifungal activity].
A number of new N-pyrazolylsalicylamides were prepared by fusion of phenyl salicylate and aminopyrazoles. The condensation reaction is influenced by the substitution at the C-4 position of the aminopyrazole. All the substances obtained were tested for antifungal activity against Cryptococcus neoformans and Candida albicans. It was found that their fungitoxicity is dependent on the structural feature.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D012457:Salicylamides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D011720:Pyrazoles; D012457:Salicylamides
Nuove N-pirazolilsalicilammidi ad attività antifungina.