The genotoxicity of selenium.
Selenium at nutritional levels has been shown to have numerous anticarcinogenic or preventative effects against carcinogen-induced breast, colon, liver and skin cancer in animals. Many of these anticarcinogenic effects have been summarized. In addition, numerous mutagenic and antimutagenic effects of selenium compounds have been reported. Some of the selenium compounds frequently tested for mutagenicity are listed in Table 1. Because of the numerous reported anticarcinogenic and preventative effects of selenium, many individuals are supplementing their diets with amounts of selenium that are greater than the recommended daily requirement. Selenium is also used widely in industrial products such as selenium rectifiers, photoelectric batteries, alloys and paints. Because selenium at higher levels is known to be toxic, there should be a greater understanding about its genotoxic as well as its beneficial effect. The object of this review is to summarize experimental evidence both for the antimutagenic and the mutagenic effect of selenium.
D000478:Alkylation; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D002474:Cell-Free System; D002875:Chromosomes / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects; D004331:Drosophila melanogaster / Q000187:drug effects; D005399:Fishes; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010944:Plants / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012643:Selenium / Q000633:toxicity*; D013090:Spermatocytes / Q000187:drug effects; D014170:Transformation, Genetic / Q000187:drug effects
D004247:DNA; D012643:Selenium