T6 antigen-positive cells in human labial salivary glands.
The distribution of T6-positive cells in glands from three healthy individuals and 18 patients suffering from various systemic disorders was studied using OKT 6 and NA1/34 monoclonal antibodies in an indirect immunoperoxidase method on frozen sections. Although no positive cells were seen in the glands of healthy controls, 10 of the 18 biopsies from the patient-group contained T6-positive cells which were mostly within glandular epithelium. The presence of T6-positive cells appeared to correlate with lymphoid infiltration of the glands. Only one of the 8 patient biopsies showing normal or minimally-altered structure contained T6-positive cells. Thus these cells are unlikely to play a role in the normal physiological function of labial salivary glands.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000276:immunology; D008046:Lip / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface