Amino acid sequence of an amyloidogenic Bence Jones protein in myeloma-associated systemic amyloidosis.
The complete amino acid sequence of an amyloidogenic Bence Jones protein (NIG-84) from an individual with myeloma-associated systemic amyloidosis has been determined. The protein, with a blocked N-terminus, represents a complete light chain consisting of 217 residues and it has a structural feature characteristic of the V lambda II subgroup. In addition to a two-residue insertion at positions 28 and 29, it has an additional rare insertion of alanine at position 100. NIG-84 is an example of the first complete sequence presented for the amyloidogenic Bence Jones protein of the V lambda II subgroup.
D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000209:etiology / Q000652:urine*; D001536:Bence Jones Protein / Q000652:urine*; D006801:Humans; D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains; D009101:Multiple Myeloma / Q000150:complications* / Q000652:urine
D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein