In vitro sensitivity of Plasmodium falciparum to chlorcycloguanil in The Gambia.
Chlorcycloguanil (10732), the active metabolite of the antifolate chlorproguanil, has been tested in vitro against 17 isolates of Plasmodium falciparum in The Gambia. Minimum inhibitory concentrations were 10(-9) molar or less. 11 isolates simultaneously tested with pyrimethamine were sensitive to 10(-8) molar concentrations of that drug.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005714:Gambia; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D002727:Proguanil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011739:Pyrimethamine / Q000494:pharmacology; D014227:Triazines
D000962:Antimalarials; D014227:Triazines; C026009:cycloguanil; D002727:Proguanil; D011739:Pyrimethamine