[Effect of sodium salicylate on insulin secretion and blood glucose behavior in metabolically healthy and type II diabetic patients].
The influence of Sodium-salicylate on insulin secretion and blood glucose behaviour was examined in 6 metabolic healthy persons and 9 type II-diabetics. Insulin secretion and blood glucose were twice examined under a combined stimulation with 100 g glucose (orally), 0.33 g glucose (Bolus injection) and 1.0 mg glucagon (i. v.) with and without a simultaneous infusion of Sodium salicylate during the whole period of examination (40 mg over 120 min). Sodium salicylate effected in type II-diabetics and metabolic healthy persons higher insulin levels. Qualitative differences of the insulin secretion pattern were not to be seen. In spite of higher insulin levels blood glucose was not influenced by Sodium salicylate. It is discussed if the results could be explained by a direct effect of Sodium salicylate on the cells ore on the metabolism of insulin and the gluconeogenesis.
D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005934:Glucagon; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012980:Sodium Salicylate / Q000008:administration & dosage*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon; D012980:Sodium Salicylate
Untersuchungen zum Einfluss von Natrium-Salizylat auf Insulinsekretion und Blutglukoseverhalten von Stoffwechselgesunden und Typ-II-Diabetikern.