Comparison of immune response stimulated in sheep, rabbits and guinea pigs by the administration of multi-component clostridial vaccines.
Over 3 years, the immunogenic responses of various batches of multi-component clostridial vaccines in sheep, rabbits and guinea pigs were compared. Fully susceptible healthy sheep were found to be more suitable than rabbits or guinea pigs for testing the potency of multi-component clostridial vaccines containing Clostridium novyi type B, C. perfringens type D, C. septicum and C. tetani, and recommendations are made that sheep are the preferred species for testing the potency of clostridial vaccines.
D000818:Animals; D000992:Antitoxins / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003013:Clostridium / Q000276:immunology*; D003017:Clostridium tetani / Q000276:immunology*; D006168:Guinea Pigs / Q000276:immunology*; D008297:Male; D009500:Neutralization Tests; D011817:Rabbits / Q000276:immunology*; D012756:Sheep / Q000276:immunology*; D013045:Species Specificity; D014121:Toxoids / Q000276:immunology*
D000992:Antitoxins; D001428:Bacterial Vaccines; C035454:Clostridium perfringens toxoid; D014121:Toxoids