[Synthesis and secretion of prolactin and growth hormone in rats with protein-calorie malnutrition and effect of administration of cortisol].
Pituitary content, intensity of synthesis and secretion of prolactin and growth hormone were studied after incubation of the rat glands in the solution containing a mixture of 3H-labeled amino acids. Pituitary hormones were separated by electrophoresis in polyacrylamide gel. The content of prolactin in the pituitary was diminished in deprived animals. Administration of cortisol decreased the content of prolactin in intact, but not in malnourished rats. In deprived animals, reduced content and synthesis of prolactin were observed, the hormone secretion was unchanged. Cortisol treatment increased incorporation of tritiated amino acids into pituitary prolactin. Malnutrition resulted in decreased content and secretion of the growth hormone; administration of cortisol increased secretion of the growth hormone, its level in the glands remaining unchanged.
D000818:Animals; D005215:Fasting; D013006:Growth Hormone / Q000378:metabolism*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D007279:Injections, Subcutaneous; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*; D051381:Rats; D013997:Time Factors
D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone
Intensivnost' sinteza i sekretsii prolaktina i gormona rosta u krys pri belkovo-kaloriĭnoĭ nedostatochnosti i vvedenii kortizola.