[Evaluation of radioimmunoassay for antithyroglobulin autoantibodies].
A statistical analysis is performed on the results of 881 determinations of thyroglobulin antibodies in humans. Antibodies were assayed comparatively by radioimmunoassay using a sandwich method and by tanned red cell haemagglutination. A very good concordance was found between the two techniques, apart from the low titer zone. A significant correlation was observed between on the one side, the radioactivity index of the diluted serum, defined as the increment of radioactivity bound by undiluted patient serum over the positive threshold, divided by this threshold, and, on the other side, the antibody titer, i.e. the reciprocal of the highest serum dilution superior to the positive threshold by radioimmunoassay. The corresponding linear regression allows to define a arbitrary unit system which associates values of the radioactivity index with an average antibody titer.
D001323:Autoantibodies / Q000032:analysis*; D006386:Hemagglutination Tests; D006801:Humans; D011863:Radioimmunoassay / Q000592:standards; D013223:Statistics as Topic; D013954:Thyroglobulin / Q000276:immunology*
D001323:Autoantibodies; D013954:Thyroglobulin
Evaluation du dosage radio-immunologique des auto-anticorps antithyroglobuliniques.