Crystallization of excipients in tablets.
Whisker-like crystals appeared on the surface of tablets that contained lactose or mannitol, a hygroscopic material such as docusate sodium, magnesium chloride, or potassium acetate, and other ingredients stored in an atmosphere of high relative humidity. The crystals were observed under a scanning electron microscope and were measured using differential scanning calorimetry and TLC. The crystals contained lactose or mannitol.
D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004339:Drug Compounding; D004356:Drug Storage; D005079:Excipients; D006813:Humidity; D007785:Lactose / Q000032:analysis; D008353:Mannitol / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D013607:Tablets / Q000032:analysis; D013696:Temperature
D005079:Excipients; D013607:Tablets; D008353:Mannitol; D007785:Lactose