[Effect of pregnancy and progesterone on the activity of an insulin-dependent cytoplasmic regulator in the liver, heart and diaphragm of rats].
The activity of the insulin-dependent regulator (IDR) in the thermostable fraction of the cytoplasm isolated from the liver, heart and diaphragm of rats as well as the glycogen level in the liver were estimated. The IDR activity in the insulin target organs and glycogen concentration in the liver were raised in the pregnant well-fed rats; a tendency to their decrease was observed after 24 h starvation. The range of changes between satiation and starvation was much more pronounced in the pregnant rats than in the controls. The IDR activity was also higher in well-fed rats receiving progesterone for 5 days and did not change after a single injection of progesterone. It was concluded that a raised level of progesterone in the blood was one of the reasons for an increase in the IDR activity in pregnant rats. An increase in the IDR activity in the insulin target organs under conditions of insulin resistance induced by pregnancy or progesterone administration testifies to the fact that the binding of insulin with its receptors is not a limiting link in the mechanism of insulin action.
D000818:Animals; D003593:Cytoplasm / Q000187:drug effects / Q000378:metabolism; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism*; D005215:Fasting; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D024101:Mitochondrial Proteins; D009206:Myocardium / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D006023:Glycoproteins; D007328:Insulin; D008112:Liver Glycogen; D024101:Mitochondrial Proteins; C031044:insulin-dependent cytoplasmic regulator protein, rat; D011374:Progesterone; D011972:Receptor, Insulin
Vliianie beremennosti i progesterona na aktivnost' insulinzavisimogo tsitoplazmaticheskogo reguliatora v pecheni, serdtse i diafragme krys.