Recombinant gamma-interferon inhibits prostaglandin-mediated and parathyroid hormone-induced bone resorption in cultured neonatal mouse calvaria.
A role of gamma-interferon in the bone remodeling process can be implicated from its interference with bone resorptive processes in cultured neonatal mouse calvaria. The immune interferon is an efficient inhibitor of endogenous prostaglandin synthesis, particularly after stimulation by thrombin or arachidonic acid, and, in addition, has a calcitonin-like inhibitory effect on PTH-induced osteoclastic bone resorption.
D000818:Animals; D000831:Animals, Newborn; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001862:Bone Resorption / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D004274:DNA, Recombinant; D007371:Interferon-gamma / Q000494:pharmacology*; D051379:Mice; D009924:Organ Culture Techniques; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors*; D011453:Prostaglandins / Q000096:biosynthesis*; D013917:Thrombin / Q000494:pharmacology
D001095:Arachidonic Acids; D004274:DNA, Recombinant; D010281:Parathyroid Hormone; D011453:Prostaglandins; D016718:Arachidonic Acid; D007371:Interferon-gamma; D013917:Thrombin; D002118:Calcium