Indomethacin and chloroquine fail to inhibit fluid loss in cholera.
A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera. All patients received intravenous infusion to restore fluid balance, but no antibiotics were given. Patients treated with oral indomethacin (total 200 mg) and chloroquine (total 1.5 g) did not have significantly different stool output than untreated controls during the five 8-h posttreatment periods (40 h).
D000328:Adult; D001835:Body Weight; D002738:Chloroquine / Q000627:therapeutic use*; D002771:Cholera / Q000188:drug therapy* / Q000378:metabolism / Q000652:urine; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008297:Male; D011897:Random Allocation
D002738:Chloroquine; D007213:Indomethacin