Effect of ketotifen treatment on cold-induced urticaria.
Eleven patients with primary acquired cold-induced urticaria were treated with ketotifen (1 mg b.i.d.) or placebo in a double-blind, crossover design trial. After seven days of ketotifen treatment, reaction times to a cold stimulus were significantly delayed in ten of the 11 subjects. No effect was seen after placebo treatment. It is concluded that ketotifen may have a place in the treatment of primary acquired cold urticaria.
D000293:Adolescent; D000328:Adult; D002648:Child; D002986:Clinical Trials as Topic; D003080:Cold Temperature / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D013997:Time Factors; D014581:Urticaria / Q000209:etiology / Q000517:prevention & control*
D010919:Placebos; D007665:Ketotifen