Endocrine changes associated with the human aging process: II. Effect of age on the number and size of thyrotropin immunoreactive cells in the human pituitary.
The thyrotropin immunoreactive cells in the pituitaries of 40 patients of varying ages were quantified after immunocytochemical staining. Thyrotroph hypertrophy and relative hyperplasia were both present in aged pituitaries. No consistent relation with the histologic features of the thyroid or adrenal, or with the cause of death, was demonstrable.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000918:Antibody Specificity; D002452:Cell Count; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000166:cytology*; D013961:Thyroid Gland / Q000473:pathology; D013972:Thyrotropin / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000096:biosynthesis
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin