Dynamics of the urinary tract in longterm vesico-ureteral reflux with infravesical obstruction and infection in pigs; V.
In a study of the dynamic function of the urinary tract in infravesically obstructed pigs with vesicoureteric reflux, 5 pigs with 6 refluxing ureters evidenced urinary tract infection after 8 and 10 weeks of obstruction. Examination showed that the median ureteric baseline activity had decreased to 0.0 A.P./min (action potentials/min). During bladder filling, no increase in activity was seen, although there was pressure equilibration between the bladder and the renal pelvis, when the reflux producing bladder pressure was reached. Only a few episodes of retrograde activity were recorded during the bladder filling. 46% of the ureteric contractions were incomplete and stopped in the mid-third of ureter. The study showed the severe, irreversible impairment of ureteric function when subjected to not only reflux and obstruction but also infection.
D000818:Animals; D004927:Escherichia coli Infections / Q000503:physiopathology; D005260:Female; D010326:Pasteurella Infections / Q000503:physiopathology; D011312:Pressure; D013552:Swine / Q000502:physiology*; D014517:Ureteral Obstruction / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology; D014552:Urinary Tract Infections / Q000503:physiopathology*; D014563:Urodynamics; D014718:Vesico-Ureteral Reflux / Q000503:physiopathology*