Serum beta-2 microglobulin in chronic lymphocytic leukaemia.
Serum-beta-2-microglobulin was measured by radioimmunoassay in 25 patients with chronic lymphocellular leukaemia in stages III-IV according to the Rai classification. A significant positive correlation was found between the absolute lymphocyte count and the serum-beta-2-microglobulin level. No similar relationship was observed between the score indicative of organ infiltration and the beta-2-microglobulin valve. On the evidence of the results, the increased production of beta-2-microglobulin is attributed in the first place to the circulating lymphocytes. The assay has been found to provide a reliable indicator, suitable for the monitoring and evaluation of therapy.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002699:Chlorambucil / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D011863:Radioimmunoassay; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin; D002699:Chlorambucil; D011239:Prednisolone