Antibody production in the brain tissue of mice immunized into the central nervous system.
Injection of T-dependent antigens into the subarachnoid space and brain parenchyma induced a marked antibody production in the spleen, as detected by plaque-forming cells (PFC). The presence of specific antibody-producing cells in the brain tissue was only observed in those animals which received antigenic challenge into the central nervous system. Local antibody production requires successive antigenic challenges with doses of sheep red blood cells larger than 2 X 10(4). Brain trauma did not influence the background numbers of spleen PFC nor did it induce the appearance of antibody-producing cells in the brains of mice challenged intra-peritoneally. The presence of specific antibody-producing cells in the brain tissue following antigenic challenge within the CNS suggests that a local immune response can be maintained in this organ.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D015478:Antigens, Heterophile / Q000276:immunology; D001921:Brain / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology
D015478:Antigens, Heterophile