Thymopentin treatment in a patient with pluriorificial pyoderma vegetans.
This paper presents longitudinal clinical and immunological findings in a patient with a life-long history of pluriorificial pyoderma vegetans, a disease characterized by a distinct immunodeficiency of T lymphocytes. After treatment with thymopentin, 50 mg s.c. three times weekly for 12 weeks, the number of T lymphocytes in peripheral blood normalized, while other impaired immunological functions failed to improve, however. The most impressive observation was the significant clinical improvement of the patient's condition.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000328:Adult; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010446:Peptide Fragments / Q000627:therapeutic use*; D011711:Pyoderma / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016305:Thymopentin; D013946:Thymopoietins / Q000627:therapeutic use*; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D010446:Peptide Fragments; D013946:Thymopoietins; D013951:Thymus Hormones; D007073:Immunoglobulin E; D016305:Thymopentin