Effects of digoxin and acetyl-digitoxin on basal and CO2-stimulated ventilation.
Eight healthy volunteers were studied to ascertain the effect of digoxin and the relatively more lipophylic cardiac glycoside, acetyl-digitoxin on ventilation. Baseline ventilation as well as the response to the inspiration of 2.2% and 4.8% carbon dioxide were assessed. Digoxin produced a depression of minute volume and oxygen consumption whereas acetyl-digitoxin produced the opposite effect. This could be the result of a relatively greater vagomimetic effect with digoxin and a greater symphatomimetic effect with acetyl-digitoxin. These findings might have clinical implications in cardiac patients who have pulmonary disease.
D000112:Acetyldigitoxins / Q000494:pharmacology*; D000328:Adult; D002245:Carbon Dioxide / Q000494:pharmacology*; D004074:Digitoxin / Q000031:analogs & derivatives*; D004077:Digoxin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D012119:Respiration / Q000187:drug effects*; D013599:Systole / Q000187:drug effects
D000112:Acetyldigitoxins; D002245:Carbon Dioxide; D004077:Digoxin; D004074:Digitoxin