Some properties of a liver protein that activates glycogen synthase b.
A soluble protein has been identified in rat liver that increases the activity of glycogen synthase without causing synthase b to a conversion. The effect of the activator is to increase synthase b activity in the presence of saturating amounts of UDP-Glc and Glc-6-P. The activator is heat sensitive and does not have protease activity. The effect of the activator is linearly proportional to the amount assayed to a saturable level and its effect is not mimicked by other proteins associated with the control of glycogen metabolism (e.g., phosphorylase).
D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D004789:Enzyme Activation; D006006:Glycogen Synthase / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000032:analysis*; D010762:Phosphorylase a / Q000378:metabolism; D011506:Proteins / Q000494:pharmacology*; D051381:Rats
D007527:Isoenzymes; D011506:Proteins; D010762:Phosphorylase a; D006006:Glycogen Synthase