Adenosine effects on glucose oxidation of adipocytes isolated from streptozotocin-diabetic rats.
Streptozotocin-induced diabetes did not impair the response of adipocytes to adenosine effects in glucose oxidation. The greatest effect of adenosine in potentiating the action of insulin was in the physiological concentration range of insulin (10-100 mu units/ml). The desensitization of cells by diabetes to the effects of insulin is therefore probably not related to the response of cells to adenosine.
D000241:Adenosine / Q000031:analogs & derivatives*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010084:Oxidation-Reduction; D010660:Phenylisopropyladenosine / Q000494:pharmacology*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex; D010660:Phenylisopropyladenosine; D005947:Glucose; D000241:Adenosine