Effects of aldosterone on urinary kallikrein and sodium excretion during fetal life.
The present study was designed to investigate the effect of acute (2 h) and chronic aldosterone (4 days) infusion on urinary kallikrein excretion rate and on renal handling of Na+ and K+ in chronically catheterized fetal lambs less than 115 days gestation (n = 6) and greater than 125 days gestation (n = 7). Chronic aldosterone infusion decreased plasma renin activity in both groups of fetuses. Both acute and chronic aldosterone infusion produced significant decreases in UNa + V in fetuses greater than 125 days and in the majority of fetuses less than 115 days gestation (five of six). Aldosterone infusion did not increase K+ excretion in either group of fetuses. It is also demonstrated that chronic aldosterone infusion induced an increase in urinary kallikrein excretion rate in both groups of fetuses. Taken together, these results demonstrate that aldosterone has antinatriuretic but no kaliuretic effects during fetal life, but produces a rise in urinary kallikrein excretion rate during the last trimester of gestation in fetal lambs.
D000450:Aldosterone / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000652:urine*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007610:Kallikreins / Q000652:urine*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012083:Renin / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000652:urine*
D002712:Chlorides; D000450:Aldosterone; D012964:Sodium; D007610:Kallikreins; D012083:Renin