[Effectiveness of a polyvalent corpuscular Pseudomonas aeruginosa vaccine, antibiotics and their combinations in experimental chronic Pseudomonas aeruginosa infection].
The data on the development of the experimental model of P. aeruginosa chronic infection in mice, produced by their intraperitoneal inoculation with the infective agent, and on the study of the properties of this model are presented. The model has been used in the experimental study of the preventive action of P. aeruginosa polyvalent corpuscular vaccine. The comparative study, carried out with the use of the proposed model, has been made with a view to evaluating the effectiveness of different methods for the treatment of P. aeruginosa chronic septic infection by means of antibiotics (polymixin B and tobramycin), P. aeruginosa polyvalent corpuscular vaccine and their combination. The combined use of this vaccine with antibiotics (polymixin B or tobramycin) has proved to give the most pronounced curative effect with respect to P. aeruginosa chronic infection.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D011112:Polymyxin B / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000276:immunology* / Q000302:isolation & purification; D013997:Time Factors; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D011112:Polymyxin B; D014031:Tobramycin
Effektivnost' polivalentnoĭ korpuskuliarnoĭ sinegnoĭnoĭ vaktsiny, nekotorykh antibiotikov i ikh kombinatsiĭ pri éksperimental'noĭ khronicheskoĭ sinegnoĭnoĭ infektsii.