Sodium cromoglycate/chlorpheniramine and sodium cromoglycate nasal sprays in the treatment of seasonal rhinitis.
Fifty-one patients suffering from symptomatic seasonal rhinitis were studied in a double-blind comparative trial using nasal sprays containing 2% sodium cromoglycate (Rynacrom; Fisons) (group 1) or 2% sodium cromoglycate plus 0,2% chlorpheniramine (group 2). Dosage was two sprays into each nostril 4 times a day. There was a marked clinical improvement in both treatment groups although the differences between the two regimens were not significant. In group 2 80% of patients thought the treatment had been effective within 2 days and in group 1 58% of patients also experienced relief of symptoms within 2 days. At final assessment, full or reasonable control was achieved in 22 of 25 patients in group 2 and in 21 of 25 patients in group 1. These differences are not significant. Fourteen patients in group 2 and 6 patients in group 1 reported a burning sensation in the nose when the spray was administered, but this was usually mild and transient. No side-effects from the use of the intranasal antihistamine/sodium cromoglycate spray were recorded.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D002648:Child; D002744:Chlorpheniramine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy*
D000336:Aerosols; D004338:Drug Combinations; D002744:Chlorpheniramine; D004205:Cromolyn Sodium