Effects of exercise training on coronary transport capacity.
Coronary transport capacity was estimated in eight sedentary control and eight exercise-trained anesthetized dogs by determining the differences between base line and the highest coronary blood flow and permeability-surface area product (PS) obtained during maximal adenosine vasodilation with coronary perfusion pressure constant. The anterior descending branch of the left coronary artery was cannulated and pump-perfused under constant-pressure conditions (approximately equal to 100 Torr) while aortic, central venous, and coronary perfusion pressures, heart rate, electrocardiogram, and coronary flow were monitored. Myocardial extraction and PS of 51Cr-labeled ethylenediaminetetraacetic acid were determined with the single-injection indicator-diffusion method. The efficacy of the 16 +/- 1 wk exercise training program was shown by significant increases in the succinate dehydrogenase activities of the gastrocnemius, gluteus medialis, and long head of triceps brachii muscles. There were no differences between control and trained dogs for either resting coronary blood flow or PS. During maximal vasodilation with adenosine, the trained dogs had significantly lower perfusion pressures with constant flow and, with constant-pressure vasodilation, greater coronary blood flow and PS. It is concluded that exercise training in dogs induces an increased coronary transport capacity that includes increases in coronary blood flow capacity (26% of control) and capillary diffusion capacity (82% of control).
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D002199:Capillary Permeability; D002860:Chromium Radioisotopes; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology; D004285:Dogs; D004492:Edetic Acid; D005260:Female; D006339:Heart Rate; D008297:Male; D010805:Physical Conditioning, Animal; D005082:Physical Exertion; D011865:Radioisotope Dilution Technique; D012711:Serum Albumin, Radio-Iodinated; D014664:Vasodilation / Q000187:drug effects
D002860:Chromium Radioisotopes; D012711:Serum Albumin, Radio-Iodinated; D004492:Edetic Acid; D000241:Adenosine