Pharmacogeriatrics.
The elderly comprise one of the fastest growing populations in the United States. By the year 2020, an estimated 45 million will be classified as elderly. Aging is a highly variable process as declines occur in physiologic functions. Alterations in cardiovascular, renal and hepatic function have the greatest effect on drug therapy. All pharmacokinetic and pharmacodynamic variables may be altered by age. Adverse drug reactions, drug interactions and poor compliance are frequent and may further complicate drug therapy. A review of those processes that commonly influence pharmacologic response and patient compliance to drug therapy is appropriate.
D000368:Aged; D000375:Aging; D001711:Biotransformation; D001823:Body Composition; D001847:Bone Diseases / Q000453:epidemiology; D004347:Drug Interactions; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D005128:Eye Diseases / Q000453:epidemiology; D005260:Female; D005767:Gastrointestinal Diseases / Q000453:epidemiology; D005853:Geriatrics; D006311:Hearing Disorders / Q000453:epidemiology; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology; D008657:Metabolic Clearance Rate; D009135:Muscular Diseases / Q000453:epidemiology; D010349:Patient Compliance; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology; D014481:United States; D014555:Urination Disorders / Q000453:epidemiology; D014652:Vascular Diseases / Q000453:epidemiology
D004364:Pharmaceutical Preparations