[A serological criterion for Bechterew's disease. Demonstration of a new antibody specificity with polytene chromosomes].
A new antibody reacting with an antigen from polytene chromosomes of Drosophila melanogaster has been found in serum of patients with Bechterew's disease. This antigen-antibody system differs from other nuclear antibodies (anti-RNP, anti-Sm, anti-Ha/SS-B) in that it is not detectable by counter-immunoelectrophoresis. The antibody could be detected in 24 out of 62 Morbus Bechterew sera in which the antibody did not strictly correlate with the appearance of HLA-B27 antigen. The new antibody specificity is a specific serological finding in patients with Bechterew's disease and is therefore suitable for use as a diagnostic, and perhaps also as a prognostic test for this type of spondylarthritis till now assumed to be seronegative.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology*; D000918:Antibody Specificity; D002648:Child; D002875:Chromosomes / Q000276:immunology; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000276:immunology*
D000906:Antibodies; D006680:HLA Antigens; D015796:HLA-B27 Antigen
Ein serologisches Kriterium für Morbus Bechterew. Nachweis einer neuen Antikörperspezifität mit polytänen Chromosomen.