T-zone histiocytes in granulomatous skin diseases.
We investigated the distribution of T-zone histiocytes by immunohistochemical demonstration of S-100 protein in granulomatous skin diseases (granuloma annulare, 8 cases; necrobiosis lipoidica, rheumatoid nodule, sarcoidosis, lupus vulgaris, and foreign-body granuloma; 5 cases each). T-zone histiocytes were regularly found in the lymphohistiocytic mantle, but also occasionally between epitheloid cells. Our results show that, besides the monocyte-macrophage system, T-zone histiocytes consistently contribute to the formation of cutaneous granulomas. These findings may indicate a role of delayed-type hypersensitivity.
D005549:Foreign-Body Reaction / Q000473:pathology; D006099:Granuloma / Q000473:pathology*; D006644:Histiocytes / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008177:Lupus Vulgaris / Q000473:pathology; D009335:Necrobiosis Lipoidica / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D012507:Sarcoidosis / Q000473:pathology; D012867:Skin / Q000032:analysis; D012871:Skin Diseases / Q000473:pathology*
D009418:S100 Proteins