[Immunological and functional characteristics of the blast cells in acute monoblastic and acute myeloblastic leukemias].
The increase in the expression of membrane receptors of monoblast cells to the Fc-fragment of immunoglobulins of classes IgG, IgA, IgM, to the C3-component of complement and FcH receptor in 8 patients with acute monoblastic leukemia and in 3 patients with acute myelomonoblastic leukemia, compared to results obtained for 11 patients with acute myeloblastic leukemia. Leukemic cells in the cases of acute myelomonoblastic and monoblastic leukemia maintained such properties of the phagocytosis (restoring Nitro-blue tetrazolium). Distinctions in degrees of expression of membrane receptors and functional activity of monoblastic and myeloblastic cells may be used as criteria of differential diagnosis of acute monoblastic and acute myeloblastic leukemia.
D000328:Adult; D000368:Aged; D002462:Cell Membrane / Q000276:immunology; D003937:Diagnosis, Differential; D005260:Female; D006098:Granulocytes / Q000276:immunology* / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000276:immunology*; D016177:Macrophage-1 Antigen; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010084:Oxidation-Reduction; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011951:Receptors, Complement / Q000032:analysis; D011961:Receptors, Fc / Q000032:analysis
D016177:Macrophage-1 Antigen; D011947:Receptors, Antigen, B-Cell; D011951:Receptors, Complement; D011961:Receptors, Fc; D009580:Nitroblue Tetrazolium
Immunologicheskaia i funktsional'naia kharakteristika blastnykh kletok pri ostrom monoblastnom i ostrom mieloblastnom leĭkoze.