Pharmacologic considerations in the management of the asphyxiated newborn.
The causes of hypoxia and ischemia in the newborn are presented and the possible mechanisms of hypoxic- ischemic cerebral injury discussed in conjunction with the current therapeutic agents used in attempt to minimize neurological sequelae. More recent, non-invasive methods for measuring cerebral injury may allow more accurate assessment of cerebral injury and permit detailed evaluation of various therapies.
D001238:Asphyxia Neonatorum / Q000150:complications / Q000188:drug therapy*; D001463:Barbiturates / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply / Q000378:metabolism; D001929:Brain Edema / Q000517:prevention & control; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005609:Free Radicals; D006801:Humans; D002534:Hypoxia, Brain / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D007231:Infant, Newborn; D010634:Phenobarbital / Q000627:therapeutic use; D014661:Vasoconstriction / Q000187:drug effects
D001463:Barbiturates; D005609:Free Radicals; D010634:Phenobarbital