Topical treatment of pressure ulcers. A randomized comparative trial of Varidase and zinc oxide.
In a single-blind, randomized trial, the efficacy of topical streptokinase-streptodornase (Varidase) solution was compared with that of zinc oxide on necrotic pressure ulcers in 28 patients. The effectiveness was determined by measuring the necrosis removal within 8 weeks. This occurred in 6 patients (43%) treated with Varidase and in 7 (50%) treated with zinc oxide. The statistical tests applied showed no significant difference between the two treatments despite the use of a high power (1-beta = 0.95). The data suggest that the two regimens are about equally effective in the treatment of necrotic tissue.
D000368:Aged; D001458:Bandages; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000188:drug therapy*; D011897:Random Allocation; D013299:Streptodornase and Streptokinase / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*; D015034:Zinc Oxide / Q000008:administration & dosage*
D007552:Isotonic Solutions; D013299:Streptodornase and Streptokinase; D015032:Zinc; D015034:Zinc Oxide