Analysis of immunoreactive insulins in man in relation to the effects of aging.
In order to elucidate the effects of aging on insulin content in human pancreas, the immunoelectrophoretic analysis of insulin was applied. The pancreas of senile humans appears to contain less total immunoreactive insulin, because of the decrement of proinsulin fraction after overnight fasting. The results suggest the involvement of insulin biosynthesis according to the aging process.
D000328:Adult; D000368:Aged; D000375:Aging; D001120:Arginine / Q000031:analogs & derivatives / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D005215:Fasting; D006801:Humans; D007122:Immunoelectrophoresis; D007328:Insulin / Q000031:analogs & derivatives / Q000032:analysis / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000378:metabolism; D008875:Middle Aged; D011384:Proinsulin / Q000032:analysis
D001786:Blood Glucose; D001798:Blood Proteins; D007328:Insulin; D011384:Proinsulin; D001120:Arginine