Serum concentration of cystatin C, factor D and beta 2-microglobulin as a measure of glomerular filtration rate.
Serum concentrations of creatinine and of the three low molecular weight (LMW) proteins cystatin C, factor D of the complement system and beta 2-microglobulin were measured in 135 consecutive patients, whose glomerular filtration rates (GFR) were determined by Cr-EDTA. In the total patient series, the reciprocals of S-creatinine and S-cystatin C were numerically and, in males, significantly more closely correlated to GFR than the reciprocals of S-factor D. The reciprocals of beta 2-microglobulin showed a weaker correlation to GFR than those of the other three substances. The calculated glomerular elimination rates of creatinine, cystatin C and factor D were normally distributed, in contrast to those of beta 2-microglobulin. According to data presented so far, cystatin C seems to be the LMW protein of first choice when GFR is to be estimated by measuring the plasma concentration of a LMW protein.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins; D002648:Child; D003166:Complement Activating Enzymes / Q000032:analysis*; D011416:Complement Factor D / Q000032:analysis*; D055316:Cystatin C; D015891:Cystatins; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009369:Neoplasms / Q000097:blood; D012216:Rheumatic Diseases / Q000097:blood; D014570:Urologic Diseases / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis*
D001798:Blood Proteins; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D001613:beta 2-Microglobulin; D003166:Complement Activating Enzymes; C493488:CFD protein, human; D011416:Complement Factor D