[Does gelatin as a blood substitute selectively depress plasma fibronectin? A clinical randomized study].
In 18 adult patients, in a randomized way, 15 ml/kg of blood were replaced either by gelatin 5.5 pc or serum protein solution. 0,5, 4 and 24 h later there was only a significant difference between the two groups in total protein and serum albumin. The low molecular weight infection related proteins alpha-1-antitrypsin, immunoglobulin G and antithrombin III, as well as the high molecular weight proteins immunoglobulin M, plasma fibronectin and alpha-2-macroglobulin were at no time significantly different between the two groups. It is concluded that gelatin as a plasma substitute does not impair the opsonising effect of plasma fibronectin upon the reticuloendothelial system.
D000328:Adult; D002986:Clinical Trials as Topic; D005353:Fibronectins / Q000097:blood*; D005780:Gelatin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000494:pharmacology*; D011897:Random Allocation
D005353:Fibronectins; D010952:Plasma Substitutes; D005780:Gelatin
Senkt Gelatine als Blutersatzmittel selektiv das Plasmafibronectin? Eine klinische randomisierte Studie.