Differential translation of virogenic and oncogenic sequences in malignant lymphoproliferative diseases and transfection of coding DNAs into NIH 3T3 cells.
The expression of oncoviral p30 polypeptides and onc gene-specific proteins has been examined in different human lymphoid malignancies. The distribution of antigen(s) related to the p30 of BaEV lacked any specificity. Antigen(s) related to the main core polypeptide of GaLV could be detected mainly in B- and O-cell malignancies. The myc-encoded protein was translated at higher levels in malignant than in normal lymphoid cells. An active src gene was identified in three acute lymphoid leukaemias and in one non-Hodgkin lymphoma of T-cell origin. Human DNAs coding oncoviral antigens or onc gene-specific proteins could be transfected into NIH 3T3 cells. These data suggest that the synergistic effect of the myc and src genes would operate in malignant transformation of some progenitors of T-cell lineage.
D000818:Animals; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D005814:Genes, Viral; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000382:microbiology*; D007962:Leukocytes / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008223:Lymphoma / Q000235:genetics / Q000382:microbiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009857:Oncogenes; D014176:Protein Biosynthesis; D014162:Transfection; D014764:Viral Proteins / Q000235:genetics
D014764:Viral Proteins