[Pathogenesis of insulin-dependent diabetes mellitus].
Insulin-dependent and independent types of diabetes mellitus differ not only in clinical traits but also in some other peculiarities: a different degree of disorder of insulin secretion, relationship with the HLA system, the presence of antibodies to pancreatic islets. The latter antibodies are typical of insulin-dependent diabetes mellitus whereas in insulin-independent diabetes mellitus they are absent. Autoimmune mechanisms of the pathogenesis of diabetes mellitus are confirmed by the presence of different antibodies to pancreatic islets, including cytoplasmic, cell-bound, cytotoxic and immunoprecipitating antibodies. The above autoantibodies were characterized, and a hypothetical mechanism of the development of insulin-dependent diabetes mellitus was proposed.
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology*; D002452:Cell Count; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007330:Insulin Antibodies / Q000276:immunology; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology; D008297:Male
D001323:Autoantibodies; D006680:HLA Antigens; D007330:Insulin Antibodies
Patogenez insulinzavisimogo sakharnogo diabeta.