[Acute recurrence of focal-segmental glomerulosclerosis in the kidney transplanted from mother to son with rapidly progressing failure of renal function].
After a brief survey, stressing upon the high susceptibility of the focal-segmental glomerulosclerosis to recurrences in transplated kidney, the authors announced one of their own observations on a youth, aged 19, that was transplated a kidney from a living donor--his mother. The basic disease in the acceptor led to chroniodialysis after 20 months of the first clinical signs. In spite of the high diuresis, that was observed after the transplantation of the maternal kidney, proteinuria persisted as early as the first days after the transplantation, creatinine did not reach the normal values and after I month chroniodialysis was again included, followed by detransplantation. The cause of that malignant course of the disease and in the transplanted kidney, the authors admitted to be the high tissue compatibility between the donor-mother and acceptor--son, one antigen in locus A and two antigens in loci B and DR. They think that with a malignant course of the focal segmental glomurolosclerosis, living donor for kidney transplantation should not be used and on no account--in case of high tissue compatibility.
D000208:Acute Disease; D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology*; D006648:Histocompatibility; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D016030:Kidney Transplantation; D008297:Male; D012008:Recurrence; D014019:Tissue Donors
Ostŭr retsidiv na ognishtno-segmentna glomeruloskleroza v transplantiran bŭbrek ot maĭka na sin s bŭrzo rukhvane na bŭbrechnata funktsiia.