Acute nonlymphocytic leukemia following gastric adenocarcinoma treated by surgery alone. Evidence for etiologic heterogeneity of "secondary" leukemias.
The case of a 36-year-old Hispanic man who developed acute nonlymphocytic leukemia 18 months following gastric adenocarcinoma treated by surgery alone is presented. Cytogenetic analysis of the leukemic cells revealed numerical and structural chromosomal rearrangements including chromosomes 5 and 7 and immunologic characterization of the blasts revealed terminal deoxynucleotidyltransferase positivity with monocytoid features. This report suggests that not all cases of acute nonlymphocytic leukemia following chemotherapy and/or radiotherapy, which characteristically display similar cytogenetic and immunologic features, should be exclusively ascribed to the leukemogenic properties of anticancer treatment.
D000208:Acute Disease; D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D001853:Bone Marrow / Q000201:enzymology / Q000648:ultrastructure; D002869:Chromosome Aberrations; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*
D000954:Antigens, Surface