Energy expenditure in acute trauma to the head with and without barbiturate therapy.
The increased energy expenditure associated with severe trauma to the head appears genuine but exhibits wide variation in its magnitude. Patients with severe acute trauma to the head without barbiturate treatment are hypermetabolic with an average energy expenditure 26 per cent over predicted. Barbiturate therapy abolishes this hypermetabolism and decreases energy expenditure to 14 per cent below predicted. In the individual patient, there appears to be a close relationship between the degree of suppression of energy expenditure and the serum barbiturate level. However, this relationship would appear to be different in each patient, and therefore, for this group, a significant correlation between energy expenditure and serum barbiturate level does not exist. The wide variability of energy expenditure in individual patients makes the estimation of energy expenditure by population predictive formulas imprecise. This may lead to incorrect estimates of caloric requirements and inappropriate provision of exogenous energy substrates. Although for those patients receiving energy expenditure and serum barbiturate levels in the individual may further aid in estimating the caloric expenditure for each individual, in order to provide appropriate amounts of calories to the patient with trauma to the head, energy expenditure should be measured in each instance.
D000293:Adolescent; D000328:Adult; D001463:Barbiturates / Q000097:blood / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000502:physiology; D006259:Craniocerebral Trauma / Q000378:metabolism* / Q000628:therapy; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005947:Glucose / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010289:Parenteral Nutrition, Total
D001463:Barbiturates; D002245:Carbon Dioxide; D005947:Glucose