[Primperan and gastroesophageal reflux. Review of the literature].
After reviewing its mechanism of action, the author summarises the action of Primperan in gastro-oesophageal reflux. Various studies have shown that the intravenous or oral administration of a single dose of Primperan induces an increase in the tone of the inferior oesophageal sphincter and an acceleration of gastric emptying in patients with gastro-oesophageal reflux. A dose of at least 10 mg is required. Long term Primperan treatment, at a dose of 40 mg/day in 4 doses, before each meal and at bedtime, significantly reduces the symptoms of gastro-oesophageal reflux and the consumption of antacids.
D001626:Bethanechol Compounds / Q000494:pharmacology; D004943:Esophagogastric Junction / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013270:Stomach / Q000187:drug effects
D001626:Bethanechol Compounds; D008787:Metoclopramide
Primpéran et reflux gastro-oesophagien. Revue de la littérature.