Rejection-related nephrotic syndrome associated with massive antiglomerular and antitubular basement membrane deposits.
A patient with end-stage renal disease due to nephronophthisis developed nephrotic syndrome following renal transplantation. Renal biopsy revealed rejection glomerulopathy with massive linear deposition of immunoglobulin (Ig) G and complement C3 along the glomerular and tubular basement membranes. The association of nephrotic syndrome with linear deposition of Ig is rare in chronic rejection of kidney allografts. The nephrotic syndrome in this case responded to treatment with plasmapheresis.
D000293:Adolescent; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology*; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000276:immunology*; D009404:Nephrotic Syndrome / Q000209:etiology*; D011183:Postoperative Complications; D011507:Proteinuria / Q000209:etiology
D007074:Immunoglobulin G