Inhibitory action of Piper betle on the initiation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rats.
When an aqueous extract of the leaves of Piper betle, a medicinal plant, was given orally at different dose levels during the initiation phase of 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in rats, higher doses of the extract inhibited the emergence of tumors. However, when the extract was fed to the rats bearing DMBA-induced mammary tumors for 8 weeks, no appreciable degree of inhibition of tumor growth was noticed. Betel leaf extract at the dose levels used in the present study did not affect the body weight gain among rats.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001114:Areca; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene