Effects of beta-hydroxybutyrate on rat embryos grown in culture.
In order to investigate further the relationship between maternal diabetes and fetal malformation, rat embryos were grown in vitro in the presence of beta-hydroxybutyrate, one of the ketone bodies produced by diabetics. At 10 mM, beta-hydroxybutyrate produced minor abnormalities and at 20 mM it produced major abnormalities in rat embryos.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D016883:Diabetic Ketoacidosis / Q000150:complications*; D004195:Disease Models, Animal; D004477:Ectogenesis; D005260:Female; D006885:Hydroxybutyrates / Q000633:toxicity*; D008855:Microscopy, Electron, Scanning; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D051381:Rats
D006885:Hydroxybutyrates