Bactericidal effects of photochemical smog constituents produced by a flow reactor. III. Communication: determination of mutagenic effects of photochemical smog on E. coli K 12 343/113.
The multipurpose strain E. coli K12 343/113 allows the simultaneous detection of different DNA alterations such as base-pair changes, frameshifts and deletions. The investigations show the detection of mutagenic potency in the mixture which is called photochemical smog, produced by a flow reactor. Responsible for these effects were ozone and hydrocarbon-radicals, but not NOx, hydrocarbons (propene, isobutene, trans-2-butene) and peroxiacetylnitrate (PAN). In the given conditions these mutagenic substances are involved in DNA alterations like base-pair changes and deletions due to the amounts of colonies in the gal+-, MTR-, and arg+-system. No frameshifts could be detected in the nad+-system.
D000085:Acetates / Q000494:pharmacology*; D000475:Alkenes / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D009153:Mutagens; D009154:Mutation; D010126:Ozone / Q000494:pharmacology*; D010463:Peracetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D012905:Smog; D014466:Ultraviolet Rays
D000085:Acetates; D000475:Alkenes; D004269:DNA, Bacterial; D009153:Mutagens; D012905:Smog; D010126:Ozone; D010463:Peracetic Acid; C021639:2-butene; C004185:peroxyacetyl nitrate