Unusual nonimmunoglobulin-containing inclusions in a case of follicular large cell lymphoma.
Intracytoplasmic inclusion bodies were found in a case of follicular large cell lymphoma. They did not react with anti-immunoglobulin antisera and showed no enzyme reactivity. On electron microscopy the inclusions consisted of loosely packed fibrillar material not surrounded by a membrane or by rough endoplasmic reticulum. They were found only in the large lymphomatous cells. Immunocytochemistry showed a reactivity of these cells with anti-HLA-Dr and the OKT10 monoclonal antibodies. The nature of the inclusions remains unknown. They differ significantly from those described in the literature in cases of B-cell lymphoproliferative disorders.
D000911:Antibodies, Monoclonal; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008224:Lymphoma, Follicular / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins