Influence of major-histocompatibility-complex-compatible and incompatible Langerhans cells on the survival of H-Y-incompatible skin grafts in rats.
BN male trunk skin grafts, the Langerhans cells (LC) of which have been replaced with major histocompatibility complex (MHC)-incompatible Lewis female cells, survive longer on BN female rats than BN male trunk skin grafts bearing BN female LC. Evidence is presented that the privilege afforded these grafts is a consequence of MHC restriction. Thus, supplanting the native LC population of BN male trunk skin grafts with MHC-compatible Lewis.1N female cells has no affect on their survival on BN female rats. Evidence is also presented that H-Y-incompatible isografts deficient in MHC-compatible LC induce tolerance of H-Y.
D000818:Animals; D005260:Female; D006085:Graft Survival; D006182:H-Y Antigen / Q000276:immunology*; D007108:Immune Tolerance; D007801:Langerhans Cells / Q000276:immunology* / Q000637:transplantation; D008285:Major Histocompatibility Complex; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D006182:H-Y Antigen