Antifungal properties of 1,2-dihydro-3-methylpyrido-(3,2-e)-as-triazine dihydrochloride (I-476).
Antifungal activity of compound I-476 (1,2-dihydro-3-methylpyrido[3,2-e]as-triazine dihydrochloride) was evaluated in vitro and in vivo. Minimal concentration inhibiting the growth of pathogenetic and saprophytic fungi in vitro ranged from 3.1 to 25 micrograms/ml. The in vivo experiments were performed in a model of experimental candidiasis in Balb/c mice. Antifungal activity of I-476 was measured by the survival time of the animals and the number of living Candida albicans cells in the kidney and spleen of the animals infected and then treated with the compound in question. A single intraperitoneal dose of I-476 markedly prolonged the survival time of mice with experimental candidiasis. The compound administered for 5 subsequent days, diminished the number of Candida albicans cells in the kidney and spleen or caused their complete elimination from these organs.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000473:pathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005658:Fungi / Q000187:drug effects; D007668:Kidney / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D013045:Species Specificity; D013154:Spleen / Q000473:pathology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000494:pharmacology*
D000935:Antifungal Agents; D014227:Triazines; C047119:I 476