Interferon-gamma accelerates immune proliferation via its effect on monocyte HLA-DR expression.
The effect of interferon-gamma (IFN-gamma) on antigen-induced and autologous proliferative responses has been investigated. The enhanced proliferative response, which resulted in the presence of IFN-gamma, was found to be the consequence of the increased density of HLA-DR induced on the accessory cells. The enhanced proliferation was at least partly due to a shift in the proliferation time course. The response to tetanus toxoid peaked 1-2 days earlier when IFN-gamma-treated monocytes acted as accessory cells than when untreated monocytes presented the antigen. Modulation of the level of DR by preincubation of the monocytes with anti-DR antibody with and without IFN-gamma demonstrated that both autologous and antigen-driven proliferation was influenced in proportion to the level of DR expressed at the time of stimulation. These experiments point to the importance of IFN-gamma in inducing an accelerated immune response via its effect on the density of DR expression on the accessory cell.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000502:physiology; D000938:Antigen-Presenting Cells / Q000276:immunology; D001667:Binding, Competitive; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis* / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D009000:Monocytes / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D013745:Tetanus Toxoid; D007371:Interferon-gamma