Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity.
Novel hydroxynaphthoquinones are reported with outstanding efficacy against Plasmodium, Eimeria and Theileria species. Biochemical evidence is presented for the selective toxicity of these compounds being due to inhibition of parasite respiratory systems.
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016782:Apicomplexa / Q000187:drug effects*; D002417:Cattle; D002645:Chickens / Q000469:parasitology; D003048:Coccidiosis / Q000188:drug therapy; D004539:Eimeria / Q000187:drug effects; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D010962:Plasmodium berghei / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects; D011528:Protozoan Infections / Q000188:drug therapy*; D013801:Theileriasis / Q000188:drug therapy; D014122:Toxoplasma / Q000187:drug effects; D014124:Toxoplasmosis, Animal / Q000188:drug therapy
D000981:Antiprotozoal Agents; D009285:Naphthoquinones