Mechanisms of lipid peroxidation.
This article provides an overview of how peroxidation of unsaturated lipids takes place and how it can be measured. Several different aspects of free-radical-mediated lipid peroxidation are discussed, including: the catalytic role of chelated iron and other redox metal ions; induction by reducing agents such as superoxide, ascorbate, and xenobiotic free radicals; suppression by antioxidant chemicals and enzymes; and how peroxidation that depends on pre-existing hydroperoxides (lipid hydroperoxide-dependent initiation of lipid peroxidation) can be distinguished from that which does not (lipid hydroperoxide-independent initiation of lipid peroxidation). Attention is also given to non-radical, singlet oxygen-driven peroxidation and how this can be resolved from radical-driven processes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008670:Metals / Q000378:metabolism; D008956:Models, Chemical; D010084:Oxidation-Reduction; D010100:Oxygen; D010777:Photochemistry; D026082:Singlet Oxygen; D013858:Thiobarbiturates / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D008670:Metals; D013858:Thiobarbiturates; D026082:Singlet Oxygen; C029684:thiobarbituric acid; D010100:Oxygen