Failure of histiocytosis X cells to express i blood group antigen.
Expression of HLADR, I, i blood group antigen and T6 antigen were studied in Histiocytosis X cells and pulmonary alveolar macrophages using double labelling immunofluorescence technique or immuno-peroxidase procedure. Alveolar macrophages express simultaneously HLADR and i blood group antigen. Histiocytosis X cells, characterized by HLADR and T6 antigens, and by their ultra-structural marker do not express i antigen. These results confirm the hypothesis that histiocytosis X cells constitute a specialized sub-population of the mononuclear phagocyte system.
D001789:Blood Group Antigens; D001847:Bone Diseases / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007048:I Blood-Group System; D007106:Immune Sera; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000276:immunology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D012886:Skull / Q000473:pathology
D001789:Blood Group Antigens; D007048:I Blood-Group System; D007106:Immune Sera