Difference in the inhibitory effect of linoleic acid hydroperoxide on prostacyclin biosynthesis between cultured endothelial cells from human umbilical cord vein and cultured smooth muscle cells from rabbit aorta.
The biosynthesis of prostacyclin in cultured endothelial cells from human umbilical cord vein was inhibited by linoleic acid hydroperoxide at a concentration of 0.1 nmol/ml (in terms of malondialdehyde), while that in cultured smooth muscle cells from rabbit aorta was inhibited only at a higher concentration of the hydroperoxide (5.0 nmol/ml).
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002478:Cells, Cultured; D003864:Depression, Chemical; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D014471:Umbilical Veins / Q000378:metabolism
D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D011464:Epoprostenol