Monocyte subsets in the production of inhibitory factor by Candida albicans-activated human T cells.
Macrophages are essential for the proliferative response of human T lymphocytes to a purified polysaccharide extract from Candida albicans (MPPS). The role of macrophages as antigen-presenting cells in the production of an antigen non-specific inhibitory factor (nsINH) by MPPS-activated T cells was also investigated. Fc receptor positive (FcR+) or negative (FcR-) plastic-adherent mononuclear cells were used as MPPS-presenting cells, and the results show that the FcR- subset is mainly responsible for the release of nsINH from activated T cells.
D000938:Antigen-Presenting Cells / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D011134:Polysaccharides / Q000494:pharmacology; D013491:Suppressor Factors, Immunologic / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D011134:Polysaccharides; D013491:Suppressor Factors, Immunologic