Fibroblast growth factor is a mitogen for oligodendrocytes in vitro.
The effect of fibroblast growth factor (FGF) on oligodendrocyte development has been studied using dissociated mixed brain cells, cultured in a previously described serum-free medium. A greater number of galactocerebroside-positive oligodendrocytes could be demonstrated after 7 days in the presence of FGF than in control values. Using combined immunofluorescence and autoradiography an increased [3H]thymidine incorporation by galactocerebroside-positive oligodendrocytes was demonstrated after various times of exposure to FGF.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D005455:Fluorescent Antibody Technique; D005699:Galactosylceramides / Q000032:analysis; D066298:In Vitro Techniques; D008934:Mitogens / Q000494:pharmacology*; D009457:Neuroglia / Q000145:classification / Q000187:drug effects*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D005699:Galactosylceramides; D008934:Mitogens; D005346:Fibroblast Growth Factors; D013936:Thymidine