The penetration of ceftazidime into peritoneal fluid in patients undergoing elective abdominal surgery.
Using paper discs we have made repeated observations during laparotomy in 31 patients after giving 1 g of ceftazidime intravenously. Samples of serum were obtained simultaneously. Rapid transfer of antibiotic occurred. Peak concentration in peritoneal fluid occurred within 10 minutes of injection (66.7 mg/l, S.E. +/- 10.6), the concurrent mean serum level being 106.0 mg/l (S.E. +/- 10.7). Thereafter levels in serum and peritoneal fluid fell roughly in parallel.
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D002442:Ceftazidime / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D011292:Premedication; D013997:Time Factors
D002442:Ceftazidime