Candida endophthalmitis after heroin abuse.
Three cases of ocular candidosis involving heroin abusers have been observed in 1983 in Toulouse department of ophthalmology. These three patients had used iranian brown heroin. Twenty similar cases have been published in these last years. This new pathology can be explained on two reasons. The first is that the drug abusers have some immunity pertubation; however, immunity exploration in these patients does not reveal any immunodeficiency. The second reason, certainly more important, is the method of using heroin. The diagnosis of Candida endophthalmitis of course based on clinical context must be proved by biological tests. Candida albicans is never identified in aqueous humor. For this reason, it seems very interesting to detect anti-candida antibodies in aqueous humor. It has been used as methods of dosage laser Nephelemetry for IgG and immunofluorescence for candidosis antibodies. The criterion used is similar to the toxoplasmosis coefficient established by Desmonts (3). In two cases, this test was the only way that permits us to have certitude of candidosis ocular diagnosis. Otherwise the observations show that anterior chamber punction is more significant when there is an anterior uveitis.
D000328:Adult; D000867:Anterior Chamber / Q000276:immunology; D000908:Antibodies, Fungal / Q000032:analysis; D001082:Aqueous Humor / Q000276:immunology; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000209:etiology*; D009877:Endophthalmitis / Q000209:etiology*; D005260:Female; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D008297:Male
D000908:Antibodies, Fungal