Monoclonal antibodies in dermatologic research. Studies with a unique cell-surface antigen defined specifically for keratinocytes by a monoclonal antibody.
Basic principles of production of monoclonal antibodies are discussed in this paper. In order to illustrate the usefulness of such production, studies of a new monoclonal antibody designated KF-2 which defines a unique cell-surface antigen found exclusively in the stratum spinosum of man and lower primates are recounted.
D000051:Acantholysis / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000302:isolation & purification; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology*; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D004817:Epidermis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D011323:Primates; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface