The effects of nicotine on PGI2 production by rat aortic endothelium.
The production of prostacyclin by rat aortic rings was measured following administration of nicotine by a single subcutaneous injection and after continuous subcutaneous infusion over 7 days. Single subcutaneous injections of nicotine at 1, 5, 10 or 20 mg/kg had no effect on prostacyclin production by rat aortic rings in comparison with controls. However, aortic rings obtained after 7 days continuous subcutaneous infusion of 0.54 g/ml of nicotine at the rate of 1 microliter per hour produced significantly less prostacyclin than control animals.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D007279:Injections, Subcutaneous; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D011460:Prostaglandins F / Q000096:biosynthesis; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D013997:Time Factors
D011460:Prostaglandins F; D012965:Sodium Chloride; D009538:Nicotine; D011464:Epoprostenol; C100006:prostaglandin F1