[Effect of enkephalins on the course of experimental izadrin-induced myocardial necrosis in the rabbit].
The effect of a synthetic analogue of encephalin was studied experimentally in 150 rabbits with neoepinephrine-induced myocardial necrosis to whom the drug was administered intravenously at the rate of 100 micrograms/kg, 1 and 6 hours later. Necrotic developments were assessed on the basis of MB CPK and LDH activity and myoglobin levels. Control animals received saline solutions or propranolol in equimolar doses. In encephalin-treated animals, enzyme activity and myoglobin values were significantly lower, an evidence of encephalins' favorable effect on the course of neoepinephrine-induced myocardial necrosis.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy*; D003402:Creatine Kinase / Q000097:blood; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine; D007527:Isoenzymes; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009211:Myoglobin / Q000097:blood; D009336:Necrosis; D011433:Propranolol / Q000627:therapeutic use
D007527:Isoenzymes; D009211:Myoglobin; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D011433:Propranolol; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D007545:Isoproterenol
Vliianie énkefalinov na techenie izadrinovogo nekroza miokarda u krolikov v éksperimente.