[Insulin production of isolated fresh and cryopreserved islands of Langerhans of rats].
The effect of glucose and Domperidon (R 33812, pharmaceutical factory Gedeon Richter, Budapest) on the insulin secretion were investigated in the isolated islets of Langerhans of rats. The insulin secretion was increased by glucose and also by Domperidon, however, in a smaller size. The insulin secretion of cryopreserved islets--stored in liquid nitrogen of -196 degrees C during 2-6 months--was equal with the secretion of fresh isolated islets. Thus the cryopreservation had not impaired the insulin secretion ability of the islets.
D000818:Animals; D004294:Domperidone / Q000494:pharmacology; D005615:Freezing; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011309:Preservation, Biological; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D004294:Domperidone; D005947:Glucose
Untersuchung der Insulinproduktion der isolierten frischen bzw. kryopräservierten Langerhans-Inseln von Ratten.