Pain relief by antidepressants: possible modes of action.
There is evidence that both tricyclic antidepressants and monoamine oxidase inhibitors can relieve chronic pain. There are a number of possible mechanisms for this phenomenon, recent studies suggest that this may be due to an analgesic rather than antidepressant effect.
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin