Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests.
Aristolochic acid (AA) has been tested for genotoxic activity in three different assays with Drosophila melanogaster (i-iii). AA induced sex-linked recessive lethals (i) and chromosome losses (ii) in male germ cells. In a newly developed fast assay with somatic cells of larvae (iii), AA induced mutant single spots as well as twin spots. The data indicate that in addition to the mutagenic activity, AA also possesses recombinogenic activity leading to somatic recombination in mitotically active cells. The experimental labor involved to detect the genotoxic activity of AA was lowest with the somatic cell assay.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D034341:Aristolochic Acids; D004317:Doxorubicin / Q000633:toxicity; D004331:Drosophila melanogaster; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D005838:Genotype; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D010616:Phenanthrenes / Q000633:toxicity*; D011995:Recombination, Genetic / Q000187:drug effects*; D012730:Sex Chromosomes / Q000187:drug effects
D000970:Antineoplastic Agents; D034341:Aristolochic Acids; D009153:Mutagens; D010616:Phenanthrenes; D004317:Doxorubicin; C000228:aristolochic acid I