Lack of inhibition of mitogen-induced lymphoproliferation by interferon gamma.
Interferon (IFN) gamma has been shown to have enhancing effects on immunocompetent cells, as for example induction of the expression of I-A antigens. In this report the effect of purified mouse IFN-gamma on mitogen-induced proliferation was studied. In contrast to the situation observed with IFN-alpha or IFN-beta, treatment by IFN-gamma had no suppressive effect on mitogenesis. Enhancing effects on DNA synthesis induced by phytohemagglutinin were observed at low concentrations of IFN-gamma in the early stage of lymphocyte activation. The effects on T cell proliferation, however, were not consistent under all experimental conditions.
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D007370:Interferon Type I; D008934:Mitogens; D007371:Interferon-gamma