Systemic allergy to human (recombinant DNA) insulin.
Allergy to insulin is extremely rare and is, in part, due to the differences in amino acid sequence of animal and human insulin. We report here a 37-year-old, white, pregnant woman who was allergic to beef/pork, purified pork, as well as human insulin. She reacted with a wheal and flare reaction in response to intradermal human and purified porcine insulins. She was desensitized to human insulin in order to continue insulin therapy during pregnancy. The course of this patient emphasizes that some patients are allergic even to human insulin and may require desensitization prior to insulin therapy.
D000328:Adult; D000818:Animals; D002417:Cattle; D003888:Desensitization, Immunologic; D003920:Diabetes Mellitus / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D013552:Swine
D007328:Insulin