Pressor activity of angiotensin II-(2-7)-hexapeptide in man.
Pressor activity and speed of metabolic degradation of angiotensin II-(2-7)-hexapeptide [ANG-(2-7)] were studied in 5 normal men. When infused iv at a rate of 72 nmol/kg X min for 7 min, ANG-(2-7) caused a very slight but statistically significant increase in blood pressure. Average blood pressure increases at 2, 5 and 7 min were 5/4, 8/10 and 8/9 mmHg, respectively, and the duration of the pressor action after the cessation of the infusion (T) was 5 min on the average. The pressor activity and T of this peptide were much less than or shorter than those of angiotensin II-(1-7)-heptapeptide [ANG-(1-7)] infused previously in the same 5 normal men at a rate of 18 nmol/kg X min, indicating that the pressor activity ratio of both the peptides in man is 1: greater than 7.2 which is similar to that of angiotensin II-(2-8)-heptapeptide (angiotensin III) and Ile5-angiotensin II (Ile5-ANG II) (1: greater than 5) and that the removal of N-terminal aspartic acid from ANG-(1-7) hastens the speed of metabolic degradation of the peptide as from Ile5-ANG II.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D012083:Renin / Q000097:blood*
D010446:Peptide Fragments; C048187:angiotensin II (2-7); D000804:Angiotensin II; D000450:Aldosterone; D012083:Renin