Impaired physical fitness and insulin secretion in normoglycaemic subjects with familial aggregation of type 2 diabetes mellitus.
Randomized subgroups from a health screening population were reinvestigated with oral glucose tolerance tests (OGTT) with simultaneous insulin and C-peptide measurements and submaximal exercise tests. Twenty-two normoglycaemic non-obese males with a strong family history of Type 2 diabetes were compared to 51 controls. While glucose levels tended to be somewhat higher, there was a tendency towards lower insulin and C-peptide levels in the hereditary group compared to controls, especially during the early phase of the OGTT, as reflected in a significant difference in the 40 min insulin level and the 0-40 min increment. Estimated maximal oxygen uptake was significantly lower in the hereditary group as were the sum ratios of insulin and C-peptide to glucose in the early phase of the OGTT. Insulin to C-peptide ratios did not differ. The data support both a decreased physical fitness, indicating peripheral insulin insensitivity, and a decreased insulin secretion among normoglycaemic individuals with familial aggregation of Type 2 diabetes.
D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007700:Kinetics; D008297:Male; D010809:Physical Fitness; D012016:Reference Values
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin