Irradiation depresses prostacyclin generation upon stimulation with the platelet-derived growth factor.
Experimental and clinical findings demonstrated rather severe arterial lesions occurring in irradiated arteries. It is suggested that a local haemostatic imbalance might be one causative factor. Liberation of PDGF causes smooth-muscle cell proliferation and PGI2 formation by the arterial wall cells, inhibiting in turn further release of PDGF from the alpha granules of the platelets. A decreased ability of irradiated vascular segments to generate PGI2 upon PDGF stimulation described here might cause haemostatic imbalance and subsequent radiation-induced lesions.
D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D011464:Epoprostenol / Q000096:biosynthesis / Q000528:radiation effects*; D006487:Hemostasis; D006801:Humans; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D011464:Epoprostenol