[Effect of irradiation on the intensity of chromatin protein synthesis in the rat liver during protection with serotonin in pulsed inhibition of translation by cycloheximide].
The model of impulse translation inhibition by cycloheximide in the rat liver was used for studying the combined and separate effect of serotonin and irradiation on the intensity of synthesis of chromatin proteins (histones and nonhistone proteins). Irradiation induces a considerable inhibition of the protein synthesis intensity, while serotonin has a contrary action, that under conditions of subsequent irradiation provides an increase in the synthesis level of histones and nonhistone proteins. Possible mechanisms of the irradiation and serotonin effect on the synthesis processes of chromatin proteins in the organism are discussed.
D000818:Animals; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis / Q000528:radiation effects; D003513:Cycloheximide / Q000494:pharmacology*; D006657:Histones / Q000096:biosynthesis / Q000528:radiation effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D011837:Radiation-Protective Agents; D012701:Serotonin; D003513:Cycloheximide
Vliianie oblucheniia na intensivnost' sinteza belkov khromatina v pecheni krys pri zashchite serotoninom v usloviiakh impul'snogo tormozheniia transliatsii tsiklogeksimidom.