Temocillin treatment of gynaecological infections with special reference to blood and tissue concentrations.
Tissue concentrations of temocillin were determined in samples from gynaecological surgical patients. Measurable concentrations of temocillin were observed during the entire time period investigated (up to 7 hours post administration). Inhibitory concentrations for the majority of susceptible bacteria were achieved. The therapeutic results observed in 40 patients with various infections (90% fully effective, 5% partially effective) confirm the high efficacy of temocillin in the treatment of gynaecological infections.
D000328:Adult; D000368:Aged; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D005836:Genitalia, Female / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D010406:Penicillins / Q000378:metabolism / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D014018:Tissue Distribution; D014552:Urinary Tract Infections / Q000188:drug therapy
D010406:Penicillins; C031367:temocillin