Intestinal permeability changes and excretion of micro-organisms in stools of infants with diarrhoea and vomiting.
The relation between diarrhoea and vomiting, the excretion of stool micro-organisms, and the passive intestinal permeability in 20 infants living in a deprived urban area was studied prospectively from birth to age 6 months. Intestinal permeability was measured from the ratio of lactulose to mannitol recovered in the urine of infants receiving feeds containing both markers. Micro-organism excretion was found to occur in both the presence and absence of gastrointestinal symptoms, but a significantly higher mean intestinal permeability was recorded in those infants with symptoms and organisms in the stool than in those with neither. An increased intestinal permeability may be a sign of mucosal damage by intestinal micro-organisms.
D003968:Diarrhea, Infantile / Q000378:metabolism / Q000382:microbiology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007408:Intestinal Absorption; D007792:Lactulose / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000378:metabolism; D010539:Permeability; D011446:Prospective Studies; D011610:Psychosocial Deprivation; D012924:Social Conditions; D014839:Vomiting / Q000378:metabolism / Q000382:microbiology*
D008353:Mannitol; D007792:Lactulose