Kinetics and free-radical mechanisms of ageing and carcinogenesis.
Kinetic investigations play an important role in gerontology. Basis research on mathematical models of the ageing process in living organisms is described and illustrated by empirical data. The role of free-radical processes in the development of pathological states, including carcinogenesis, and in ageing is considered. The role of free-radical reactions in the conversion of known carcinogens in the organism and the interaction of their active radical forms with the most important biomacromolecules is discussed. It is shown that antioxidants of low toxicity, which inhibit radical processes, are anticarcinogenic, and data are given on their experimental utilization as possible 'geroprotectors'.
D000375:Aging; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism; D004260:DNA Repair; D005609:Free Radicals; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D009026:Mortality; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism
D000970:Antineoplastic Agents; D000975:Antioxidants; D002273:Carcinogens; D005609:Free Radicals