Cultured human neural cells accumulate a heat-shock protein during acute herpes simplex virus infection.
Herpes simplex virus-1 (HSV-1) infection of cultured human neural cells causes the accumulation of a host cell-encoded nuclear protein identified as a 57,000 mol.wt. stress protein by monoclonal antibody TI56. This protein is cell cycle-related in fibroblast, may mediate host cell control during HSV infection and could play a role in the regulation of HSV latency.
D000911:Antibodies, Monoclonal; D005333:Fetus; D005347:Fibroblasts; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006561:Herpes Simplex / Q000378:metabolism*; D006801:Humans; D013116:Spinal Cord
D000911:Antibodies, Monoclonal; D006360:Heat-Shock Proteins