Stimulation by food of peripheral plasma immunoreactive growth hormone releasing factor.
A highly specific radioimmunoassay has been used to study changes in peripheral human plasma growth hormone releasing factor (GRF) following the ingestion of food. From a mean basal plasma concentration of 11.8 pg/ml (range less than 7-15.4 pg/ml) in six normal individuals following overnight fast, the circulating concentration of GRF-like immunoreactivity increased to a mean maximum of 36.7 pg/ml (range 20.2-77.0 pg/ml) sampled 120 min after a mixed breakfast. This increase in GRF was accompanied by suppression rather than stimulation of circulating growth hormone. The predominant source of peripheral circulating GRF-like immunoreactivity may therefore by extrahypothalamic and responds to an oral food stimulus.
D000328:Adult; D004435:Eating; D005260:Female; D013006:Growth Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D011863:Radioimmunoassay
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone