Toxicological evaluation of commercial alkyldimethylamine oxides: two-year chronic feeding and dermal studies.
Chronic feeding and dermal studies were conducted with commercial alkyldimethylamine oxides (ADAO) in rats and mice. Rats were dosed with 0.01, 0.1, or 0.2% w/v ADAO (on a 100% active basis) in their diet for 104 weeks. Mice were exposed to ADAO via a dermal application of 0.1 ml of an aqueous solution of ADAO at concentrations of 0.05, 0.13, or 0.26% w/v ADAO (on a 100% active basis) once daily three times per week for 104 weeks. No compound-related carcinogenic effects were observed in either chronic test.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004032:Diet; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009153:Mutagens; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics; D012871:Skin Diseases / Q000139:chemically induced*; D013997:Time Factors
D002273:Carcinogens; D009153:Mutagens