Immunoelectron microscopic study of Hodgkin's disease.
Seven patients with Hodgkin's disease were studied for the presence of lysozyme and alpha-1-antitrypsin activity by immunoelectron microscopy. As a result, Reed-Sternberg cells, Hodgkin's cells, and atypical cells were distinctly positive for lysozyme in four cases and weakly positive in the remaining three cases. These cells were also positive for alpha-1-antitrypsin in all cases. Because the cells of the monocyte-macrophage lineage also bore lysozyme and alpha-1-antitrypsin, it is suggested that Reed-Sternberg cells, Hodgkin's cells, and the atypical cells are derived from the monocyte-macrophage lineage.
D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000032:analysis / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007951:Leukemia, Myeloid / Q000473:pathology; D008198:Lymph Nodes / Q000032:analysis / Q000473:pathology; D008206:Lymphatic Diseases / Q000473:pathology; D008264:Macrophages / Q000032:analysis; D008854:Microscopy, Electron; D009000:Monocytes / Q000032:analysis; D009113:Muramidase / Q000032:analysis; D012507:Sarcoidosis / Q000473:pathology; D014376:Tuberculosis / Q000473:pathology; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000515:alpha 1-Antitrypsin; D009113:Muramidase