The effect of nerve lesions on the inflammatory response to injury.
The effects of surgical denervation, capsaicin, and 6-Hydroxydopamine pretreatment on the inflammatory response to thermal injury have been investigated in the rat. Surgical denervation and capsaicin pretreatment reduced the cellular and exudative reactions to the injury. 6-Hydroxydopamine appeared to have a selective effect on the exudative reaction only. The effects of surgical denervation are partly explained by local and systemic effects of the procedure.
D000818:Animals; D001768:Blister / Q000378:metabolism / Q000473:pathology; D002211:Capsaicin / Q000494:pharmacology; D002452:Cell Count; D006892:Hydroxydopamines; D007249:Inflammation / Q000503:physiopathology*; D007962:Leukocytes / Q000473:pathology; D016627:Oxidopamine; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology*; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013563:Sympathectomy, Chemical
D006892:Hydroxydopamines; D011506:Proteins; D016627:Oxidopamine; D002211:Capsaicin