[Transplacental transfer of 5 antibiotics by in vitro human placental perfusion].
Transplacental transfer of 5 semi-synthetic penicillins which act on Gram + and Gram - bacteria were studied by in vitro perfusion of the human placenta. These penicillins were: amoxicillin, apalcillin, mezlocillin, piperacillin and ticarcillin. Placental transfer of these 5 antibiotics varies between 5 and 7% of the maternal concentration. Amoxicillin 7,62% - apalcillin 5,66% - mezlocillin 5,4% - piperacillin 7,37% - ticarcillin 4,86%. The reasons for such low transfer and the clinical repercussions of these results are discussed by the authors.
D000658:Amoxicillin / Q000378:metabolism; D000667:Ampicillin / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008431:Maternal-Fetal Exchange; D008802:Mezlocillin / Q000378:metabolism; D009287:Naphthyridines; D010406:Penicillins / Q000378:metabolism*; D010477:Perfusion; D010878:Piperacillin / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D013982:Ticarcillin / Q000378:metabolism
D009287:Naphthyridines; D010406:Penicillins; C012122:apalcillin; D000667:Ampicillin; D000658:Amoxicillin; D013982:Ticarcillin; D008802:Mezlocillin; D010878:Piperacillin
Etude du passage transplacentaire de cinq antibiotiques par perfusion in vitro du placenta humain.