Unexplained infertility and its treatment with intermittent GnRH application.
Spontaneous LH fluctuations were estimated in patients with unexplained infertility. This suggested that irregular LH bursts and a slightly decreased frequency are present in these individuals. Administration of sex steroids suppressed LH serum levels and no LH pulses were noted thereafter. Intermittent GnRH application by means of an automatic pump (Zyklomat) induced regular LH fluctuations: follicular maturation was enhanced using 20 micrograms GnRH per pulse than with 10 micrograms; the former dose however appeared to be supra-physiological. Three pregnancies occurred in these patients who had not conceived following previous treatment with clomiphene and human menopausal gonadotropins.
D004304:Dosage Forms; D004958:Estradiol / Q000097:blood; D005260:Female; D005498:Follicular Phase; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood
D004304:Dosage Forms; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone