recA-independent mutagenicity induced by chloroethylene oxide in E. coli.
The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10(-2) recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arises mainly from miscoding DNA adducts.
D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005027:Ethylene Oxide / Q000031:analogs & derivatives / Q000494:pharmacology*; D007700:Kinetics; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011938:Rec A Recombinases / Q000235:genetics*; D013045:Species Specificity
D009153:Mutagens; C015061:chloroethylene oxide; D011938:Rec A Recombinases; D005027:Ethylene Oxide