The effect of glucose upon restitution after transient cerebral ischemia: a summary.
The study describes a reproducible model of complete brain ischemia in rats. Rats with different plasma glucose concentrations were exposed to 10 min of complete cerebral ischemia achieved by compression of neck vessels by a pneumatic cuff. All 30 rats, except one, in which pre-ischemic plasma glucose level were lower than 22 mM (range 1.6-22) survived 10 min complete ischemia and made a similar recovery. Ten rats with pre-ischemic plasma glucose levels above 22 mM (range 22-47.2) died from seizures in the post-ischemic period. Post-ischemic treatment of seizures and hyperglycemia in the hyperglycemic rats significantly improved recovery. In conclusion, pre-ischemic hyperglycemia above 22 mM impairs recovery after complete ischemia by inducing seizures, post-ischemic hyperglycemia and lactic acidosis.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001921:Brain / Q000098:blood supply; D003975:Diazepam / Q000627:therapeutic use; D004195:Disease Models, Animal; D007328:Insulin / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D010424:Pentobarbital / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow
D001786:Blood Glucose; D007328:Insulin; D010424:Pentobarbital; D003975:Diazepam