Plasmid-cured Salmonella enteritidis AL1192 as a candidate for a live vaccine.
We report the immunizing capacity of Salmonella enteritidis AL1192, a strain that has been cured of a 36-megadalton plasmid, to protect ddY mice against subsequent challenge with virulent salmonellas. This strain, which was given subcutaneously at a dose of 10(6) organisms, provided significant protection against oral, subcutaneous, or intraperitoneal challenge by virulent wild-type strains of not only S. enteritidis, but also S. dublin, S. naestved, and S. typhimurium.
D000818:Animals; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D010957:Plasmids; D012477:Salmonella enteritidis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D014612:Vaccines; D014774:Virulence
D014612:Vaccines