[Yeast resistance to polyene antibiotics. IV. A study of the inheritance of changes in the sterol composition of Saccharomyces cerevisiae yeasts caused by mutations of nystatin resistance].
Sterol content in haploid and diploid strains of yeast having mutations of resistance to nystatin were studied by UV spectrometry method. Heterozygous diploids carrying one or two nystatin resistance mutations have, as a rule, the sterol content of the wild type strains. Segregants of the same genotype demonstrate differences in sterol content. Double mutants nys1 nys2 and nys1 nys3 have UV spectra typical for single nys2 and nys3 mutants, respectively. Double mutants nys1 nysX are characterized by a "mixed" UV spectra of sterols.
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D004171:Diploidy; D004352:Drug Resistance, Microbial; D005838:Genotype; D006238:Haploidy; D006579:Heterozygote; D009154:Mutation; D009761:Nystatin / Q000037:antagonists & inhibitors*; D011090:Polyenes / Q000037:antagonists & inhibitors; D012441:Saccharomyces cerevisiae / Q000032:analysis / Q000187:drug effects / Q000235:genetics*; D013261:Sterols / Q000032:analysis / Q000235:genetics*
D000900:Anti-Bacterial Agents; D011090:Polyenes; D013261:Sterols; D009761:Nystatin
Rezistentnost' drozhzheĭ k polienovym antibiotikam. Soobshchenie IV. Izuchenie nasledovaniia izmeneniĭ v sostave sterinov, obuslovlennykh mutatsiĭ ustoĭchivosti k nistatinu u drozhzheĭ Saccharomyces cerevisiae.