[The effect of meclofenoxate on the growth, fertility and number of offspring in Wistar rats].
In experiments with rats concerning teratological aspects of meclofenoxate it was demonstrated that this drug reduces the teratogenicity in Wistar rats. Meclofenoxate leads in the fetuses of rats to a significant increase of the weight when the dams were treated prenatally with the ester. Besides, meclofenoxate causes in continuous series of generations an increase of fertility which results in a higher number of offsprings.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D006016:Glycolates / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects*; D002504:Meclofenoxate / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens
D006016:Glycolates; D013723:Teratogens; D003520:Cyclophosphamide; D002504:Meclofenoxate
Einfluss von Meclofenoxat auf die Gewichtsentwicklung, Fertilität und Wurfgrösse bei Wistar-Ratten.