Effects of treatment with azathioprine and cyclosporin A on interferon-gamma production by peripheral blood leukocytes of renal allograft recipients.
We have studied the concanavalin A (ConA)-induced interferon gamma (IFN-gamma) production of peripheral blood mononuclear cells (PBMC) of renal allograft recipients. Both under immunosuppressive treatment with azathioprine and with cyclosporin A (CsA) the PBMC of these patients proved deficient for IFN-gamma production when compared to those of healthy controls. After conversion from conventional azathioprine to CsA medication the ConA-induced IFN-gamma production increased.
D001379:Azathioprine / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D016030:Kidney Transplantation; D007962:Leukocytes / Q000378:metabolism*; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007371:Interferon-gamma; D001379:Azathioprine