Genes for insulin I and II, parathyroid hormone, and calcitonin are on rat chromosome 1.
Insulin, parathyroid hormone, and calcitonin are polypeptide hormones that regulate important physiological processes in target tissues. Rat genes encoding each hormone were chromosomally assigned to rat chromosome 1. Both rats and mice have two insulin genes (I and II). However, in contrast to mice in which insulin I and II are asyntenic, rat insulin I and II were both localized to chromosome 1. This study identifies a conserved syntenic group on rat chromosome 1, and implies that mouse insulin I and II genes were chromosomally separated after rats and mice diverged 20-35 million years ago.
D000818:Animals; D002116:Calcitonin / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D004247:DNA; D006822:Hybrid Cells; D007328:Insulin / Q000235:genetics*; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D010281:Parathyroid Hormone / Q000235:genetics*; D051381:Rats
D007328:Insulin; D010281:Parathyroid Hormone; D002116:Calcitonin; D004247:DNA