Possible human analogs of the murine T/t complex.
After a short description of the T-t complex of the mouse, a comparison between the MHCs of mouse and man and HLA marker-disease associations, possible candidates for human t-analogs are discussed. The hypothesis is put forward that some extended MHC haplotypes might be human analogs of murine t-mutants.
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D003434:Crossing Over, Genetic; D004195:Disease Models, Animal; D005804:Genes, Lethal; D005808:Genes, Recessive; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D013131:Spine / Q000002:abnormalities