[Sterol composition in yeast strains sensitive and resistant to nystatin].
The sterol composition of nystatin-sensitive and nystatin-resistant strains of Saccharomyces cerevisiae was being studied by gas-liquid chromatography and mass-spectroscopy. The synthesis of ergosterol is completely suppressed in polyene-resistant mutants. Three sterols derived from cholesterol were identified in the mutants: cholesta-8,24-diene-3 beta-ol, cholesta-5,7,24-triene-3 beta-ol, and cholesta-5,7,22,24-tetraene-3 beta-ol.
D002849:Chromatography, Gas; D004352:Drug Resistance, Microbial; D013058:Mass Spectrometry; D009154:Mutation; D009761:Nystatin / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000032:analysis* / Q000187:drug effects / Q000235:genetics; D013261:Sterols / Q000032:analysis*
D013261:Sterols; D009761:Nystatin
Sostav stearinov u shtammov drozhzheĭ, chuvstvitel'nykh i ustoĭchivykh k nistatinu.