Coexistence of renin and cathepsin B in epithelioid cell secretory granules.
Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin B-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin B is suggested to be involved in the activation of renin prior to secretion.
D000818:Animals; D002401:Cathepsin B; D002403:Cathepsins / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D004848:Epithelium / Q000201:enzymology / Q000648:ultrastructure; D007606:Juxtaglomerular Apparatus / Q000201:enzymology* / Q000648:ultrastructure; D007668:Kidney / Q000201:enzymology* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D012083:Renin / Q000378:metabolism*
D002403:Cathepsins; D002401:Cathepsin B; D012083:Renin