Protection against Yersinia infection induced by non-virulence-plasmid-encoded antigens.
Specific immunity against Yersinia was induced by plasmid-encoded antigens not associated with virulence. Mice were immunised with viable bacteria from a virulence-plasmid-cured strain of Y. pseudotuberculosis. This antigenic stimulation generated specific protection against virulence-plasmid-harbouring strains of Y. pseudotuberculosis and Y. pestis, demonstrating that protection can be generated by organisms lacking plasmid-encoded virulence antigens.
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D005260:Female; D007110:Immunity, Active; D007114:Immunization; D008088:Listeriosis / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D010930:Plague / Q000276:immunology* / Q000382:microbiology; D010957:Plasmids; D013154:Spleen / Q000382:microbiology; D014774:Virulence; D015007:Yersinia / Q000235:genetics / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity; D015009:Yersinia Infections / Q000276:immunology* / Q000382:microbiology; D015008:Yersinia enterocolitica / Q000254:growth & development / Q000276:immunology; D015010:Yersinia pestis / Q000254:growth & development / Q000276:immunology; D015012:Yersinia pseudotuberculosis Infections / Q000276:immunology / Q000382:microbiology
D000942:Antigens, Bacterial