Influence of growth phase on the susceptibility of Candida albicans to butoconazole, oxiconazole, and sulconazole.
Three topical antifungal imidazoles were examined for fungicidal potential. At 8 X 10(-5) M, butoconazole, oxiconazole, and sulconazole were strictly fungistatic against early stationary phase Candida albicans cells diluted into fresh medium. With early logarithmic phase organisms, oxiconazole again was fungistatic, but sulconazole and butoconazole were highly lethal at only 2 X 10(-5) M.
D002176:Candida albicans / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013997:Time Factors
D007093:Imidazoles; C017125:butoconazole; C033308:sulconazole; C022155:oxiconazole