[Effects of 1,25-dihydroxyvitamin D3 on bone resorption and 45Ca2+ efflux in bone cells].
1,25-dihydroxyvitamin D3[1,25(OH)2D3] effects on bone resorption in organ culture and on 45Ca2+ efflux rates in bone cells were measured in presence of a calcium channel inhibitor, diltiazem. Though, diltiazem reduced the 45Ca release from mice calvaria it did not act at the same Ca compartment as 1,25(OH)2D3 to alter Ca2+ flux parameters. It therefore seems difficult to hypothesize a simple relationship between bone resorption and Ca2+ movements in bone cells.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004110:Diltiazem / Q000494:pharmacology; D051379:Mice; D009924:Organ Culture Techniques; D051381:Rats
D002132:Calcium Radioisotopes; D004110:Diltiazem; D002117:Calcitriol; D002118:Calcium
Effets de la 1.25-dihydroxyvitamine D3 sur la résorption osseuse et l'efflux du 45Ca2+ dans les cellules osseuses.