Plasma follicle-stimulating hormone, luteinizing hormone, and sex hormones in patients with gout.
Plasma levels of follicle-stimulating hormone, luteinizing hormone, testosterone, progesterone, 17 beta-estradiol, and cortisol were examined in normal subjects and gout patients under baseline conditions and after clomiphene stimulation. A significant decrease in follicle-stimulating hormone, luteinizing hormone, and 17 beta-estradiol was observed both in male and female gout patients; in the same patients, the plasma testosterone: 17 beta-estradiol ratio was found to be significantly higher than in control subjects. The changes observed suggest a possible role played by 17 beta-estradiol in the regulation of purine biosynthesis and uric acid metabolism.
D000328:Adult; D000368:Aged; D002996:Clomiphene / Q000494:pharmacology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006062:Gonadotropins / Q000378:metabolism; D006073:Gout / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D014527:Uric Acid / Q000652:urine
D012739:Gonadal Steroid Hormones; D006062:Gonadotropins; D002996:Clomiphene; D014527:Uric Acid; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006854:Hydrocortisone