[Hemodynamic effects of phentolamine in acute and chronic mitral insufficiency after myocardial infarction].
The haemodynamic effects of phentolamine, a selective alpha blocker, were studied in patients with severe mitral regurgitation and cardiac failure in the acute (Group I, 7 cases) or chronic (Group II, 7 cases) phase of myocardial infarction. After 1 hour's treatment a rise in cardiac index (+29 p. 100, p less than 0.001 and +36 p. 100, p less than 0.01), and systolic index (+19 p. 100, p less than 0.001 and +19 p. 100, p less than 0.05) were observed; the V wave of the pulmonary capillary pressure recording decreased (-32 p. 100, p less than 0.005; -26 p. 100, p less than 0.01). Oxygen transport also increased by an average of 36 p. 100, p less than 0.001, without a significant change in arterial pp O2. These results show that phentolamine improves the haemodynamics and decreases mitral regurgitation in the acute and in the chronic phases of myocardial infarction.
D000208:Acute Disease; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000188:drug therapy* / Q000209:etiology; D009203:Myocardial Infarction / Q000150:complications*; D010646:Phentolamine / Q000627:therapeutic use*; D013997:Time Factors
D010646:Phentolamine
Effets hémodynamiques de la phentolamine sur les insuffisances mitrales aiguës et chroniques après infarctus du myocarde.