Methylphenidate and children with attention deficit disorder. Dose effects on classroom academic and social behavior.
The short-term, dose-response effects of methylphenidate hydrochloride were evaluated on academic and social classroom measures in 29 children with attention deficit disorder. In a double-blind, cross-over design with order randomized, children received a placebo for two weeks and three doses of methylphenidate hydrochloride (0.15 mg/kg, 0.3 mg/kg, and 0.6 mg/kg) for one week each. Dependent measures included the output and accuracy of performance in grade-appropriate reading comprehension workbooks and arithmetic problems, spelling word acquisition, and observations of disruptive and on-task behavior. Beneficial drug effects and linear dose-response curves on all dependent measures were found. The results suggest that beneficial methylphenidate effects on classroom behavior may be accompanied by enhanced academic achievement in some hyperactive children.
D000124:Achievement; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008774:Methylphenidate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011340:Problem Solving / Q000187:drug effects; D011897:Random Allocation; D011932:Reading; D012919:Social Behavior
D008774:Methylphenidate