Dose-response relationship of vindeburnol based on spectral analysis of posturographic recordings.
The dose-response relationship of vindeburnol has been investigated by assessing postural activity in a population of elderly patients, using posturography, an objective method for measuring balance. A controlled double blind trial was done in two periods: during the first week each patient received placebo, and during the second week either placebo or vindeburnol 30, 60 or 90 mg/d was given. Subjects underwent three posturographic recordings at weekly intervals (prior to treatment, after one week on placebo and after one week of treatment). There was no placebo effect. A significant decrease in the sagittal and lateral energies of body sway was found after vindeburnol, which indicates an improvement in balance. The improvement was proportional to the daily dose of vindeburnol.
D000368:Aged; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture; D011897:Random Allocation; D014748:Vinca Alkaloids / Q000494:pharmacology*; D014749:Vincamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*
D014748:Vinca Alkaloids; D014749:Vincamine; C044616:vindeburnol