Cellular abnormalities and reduced colony-forming cells in chronic neutrophilic leukaemia.
A case of chronic neutrophilic leukaemia with a 4-year survival is reported. The platelet function is abnormal due to a deficiency of storage pool adenine nucleotides. Neutrophils have a paucity of azurophil and specific granules. Circulating and bone marrow colony-forming cells are markedly reduced.
D000227:Adenine Nucleotides / Q000097:blood; D000368:Aged; D001792:Blood Platelets / Q000502:physiology; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000473:pathology* / Q000503:physiopathology; D008854:Microscopy, Electron; D009504:Neutrophils / Q000473:pathology*
D000227:Adenine Nucleotides