The influence of captopril, the nitrates and propranolol on apparent liver blood flow.
Indocyanine green estimated apparent liver blood flow was measured in normal volunteers following glyceryl trinitrate, propranolol, isosorbide mononitrate and captopril. Glyceryl trinitrate and propranolol significantly reduced apparent liver blood flow. Isosorbide mononitrate did not alter apparent liver blood flow or produce an additional reduction in apparent liver blood flow when combined with propranolol. Captopril did not alter apparent liver blood flow despite a significant fall in mean arterial pressure and rise in plasma renin activity. Captopril and isosorbide mononitrate if shown to reduce portal pressure, do so without a fall in apparent liver blood flow.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007208:Indocyanine Green; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives / Q000494:pharmacology*; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D005996:Nitroglycerin / Q000494:pharmacology; D011187:Posture; D011392:Proline / Q000031:analogs & derivatives*; D011433:Propranolol / Q000494:pharmacology*; D012083:Renin / Q000097:blood
D000450:Aldosterone; D011392:Proline; D002216:Captopril; D011433:Propranolol; D012083:Renin; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D007208:Indocyanine Green