Studies on mutagen-sensitive strains of Drosophila melanogaster. VII. Effects of repair deficiency in males on X-ray-induced sex-linked recessive lethals in spermatozoa.
The response of mature spermatozoa to the X-ray induction (500 R and 3000 R) of sex-linked recessive lethals was studied in Drosophila melanogaster males known to be deficient in excision- or post-replication repair of UV damage in somatic cells. The results show that the induced frequencies of recessive lethals in the excision-repair-deficient males (mei-9a and mei-9L1) are similar to those in the appropriate repair-proficient males (mei+ and Berlin-K). However, in the post-replication-repair-deficient males (w mus(1)101D1), these frequencies are significantly lower than in the comparable repair-proficient males (w) after 500 R, but not after 3000 R.
D000818:Animals; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics / Q000528:radiation effects*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009154:Mutation / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014965:X-Rays