Experimental reproduction of leprosy in seven-banded armadillos (Dasypus hybridus).
Four autochthonous seven-banded armadillos (Dasypus hybridus) from Argentina which developed disseminated leprosy are reported. The average time from inoculation to death was 14.6 months. Acid-fast bacilli (AFB) were found in the skin, nerves, spleen, lymph nodes, lungs, meninges, and striated muscle. Several tests were used to prove that the AFB found in the infected animals were Mycobacterium leprae: a) failure to grow in standard culture media for mycobacteria, b) extraction of acid-fastness with the pyridine test, c) patterns of growth in the mouse foot pad, and d) histopathologic features.
D000818:Animals; D001135:Armadillos; D005260:Female; D007918:Leprosy / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009132:Muscles / Q000473:pathology; D009166:Mycobacterium leprae / Q000254:growth & development; D010525:Peripheral Nerves / Q000473:pathology; D012867:Skin / Q000473:pathology; D013997:Time Factors; D004490:Xenarthra / Q000382:microbiology*