Experimental models of nephrotoxic acute renal failure.
Table 1 summarizes the findings in these three models of nephrotoxic acute renal failure. As can be noted, leakage of filtrate across damaged tubular epithelium is a factor in each instance. Some degree of tubular obstruction is probably present in each model but is of major importance only with severe tubular injury. Hemodynamic alterations and a change in the ultrafiltration coefficient may also play a role in the renal functional impairment. It is not presently possible to quantitatively determine the significance of each of these abnormalities in a given experimental model.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity; D004195:Disease Models, Animal; D004285:Dogs; D005839:Gentamicins / Q000633:toxicity; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply; D007678:Kidney Glomerulus / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D012078:Renal Artery Obstruction / Q000139:chemically induced / Q000503:physiopathology; D014502:Uranyl Nitrate / Q000633:toxicity
D005839:Gentamicins; D014502:Uranyl Nitrate; D002945:Cisplatin