Experimental studies on prenatal treatment of congenital anomalies.
Development of fetal animal models for congenital anomalies helps elucidate the pathophysiological consequences of the disease process as well as the efficiency of prenatal intervention in ameliorating the disease. The experimental work that supports the pathophysiological rationale for in-utero correction of diaphragmatic hernia and urinary tract obstruction is reviewed in this article.
D000818:Animals; D000013:Congenital Abnormalities / Q000601:surgery*; D004195:Disease Models, Animal / Q000503:physiopathology*; D005260:Female; D005865:Gestational Age; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D008168:Lung / Q000002:abnormalities; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011312:Pressure; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D012756:Sheep; D014570:Urologic Diseases / Q000150:complications / Q000151:congenital / Q000503:physiopathology