Induction of penicillin-binding proteins under catabolite-repressed conditions.
Decoyinine, an inhibitor of GMP synthetase, was used to induce sporulation under catabolite-repressed conditions in Bacillus subtilis. Sporulation-specific penicillin-binding proteins 4* and 5* were produced in abundance, and there was an increase in vegetative penicillin-binding proteins 2B and 3. These results, which were completely blocked by addition of guanosine, suggest that synthesis of penicillin-binding proteins is neither catabolite repressed nor directly dependent on the stringent response.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins; D002268:Carboxypeptidases / Q000096:biosynthesis*; D002352:Carrier Proteins / Q000096:biosynthesis*; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase / Q000096:biosynthesis*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D013171:Spores, Bacterial / Q000502:physiology
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; C012182:angustmycin A; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002268:Carboxypeptidases; D002267:Muramoylpentapeptide Carboxypeptidase; D000241:Adenosine