Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis.
Synovial tissues were studied, using immunofluorescence techniques, for localization of lymphocytic infiltrates and immune reactants, including C3, C5b-9, C9, and Ia antigen. Tissue distribution of interleukin-2 (IL-2) and gamma-interferon was also determined, using mouse monoclonal antibodies. IL-2 was found in association with OKT8 and OKT4 T cells, and gamma-interferon was noted in association with T cells, B cells, and macrophages. Staining both for IL-2 and for gamma-interferon was surprisingly faint in view of the intensity of lymphocytic infiltration.
D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis*; D007376:Interleukin-2 / Q000032:analysis*; D008264:Macrophages / Q000276:immunology; D013583:Synovial Membrane / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology; D014018:Tissue Distribution
D007376:Interleukin-2; D007371:Interferon-gamma