Lymphocyte proliferative responses to bacterial antigens in B27-associated arthropathies.
Lymphocyte transformation tests to Yersinia enterocolitica 0:3 and 0:6, Klebsiella pneumoniae and Streptococcus faecalis antigens have been carried out in ankylosing spondylitis, reactive arthritis/Reiter's disease and controls. Ankylosing spondylitis cases gave significantly lower responses than reactive arthritis/Reiter's to Yersinia enterocolitica 0:6 (p = 0.003) and Klebsiella pneumoniae (p = 0.008), and less than controls to S. faecalis (p = 0.008). It appears, therefore, that within the B27 arthritis population there is heterogeneity of cell-mediated response to certain enteric bacteria, with the hyporesponders manifesting ankylosing spondylitis and the hyper-responders reactive arthritis/Reiter's disease.
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology*; D001168:Arthritis / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology; D013293:Enterococcus faecalis / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D007111:Immunity, Cellular; D007711:Klebsiella pneumoniae / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000276:immunology; D015008:Yersinia enterocolitica / Q000276:immunology
D000942:Antigens, Bacterial; D006680:HLA Antigens; D015796:HLA-B27 Antigen