Endothelium influences coronary and aortic vasomotion by release of an unstable humoral factor.
Using an isolated perfused coronary-artery preparation, we have demonstrated the ability of endothelium inhibit markedly to vasomotion in rabbit coronary arteries. Using a bioassay system, we have shown this effect to be mediated via the release of an unstable humoral agent (t 1/2 approximately equal to 6 sec) from endothelial cells, and we have partially characterized its chemical nature.
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology; D001798:Blood Proteins / Q000502:physiology*; D000001:Calcimycin / Q000494:pharmacology; D003331:Coronary Vessels / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000502:physiology; D007783:Lactones / Q000378:metabolism; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D010477:Perfusion; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects; D014666:Vasomotor System / Q000502:physiology
D001798:Blood Proteins; D007783:Lactones; D014662:Vasoconstrictor Agents; D000001:Calcimycin; D000255:Adenosine Triphosphate; D000109:Acetylcholine