Function of human autologous kidney grafts after extracorporeal preservation with Sacks' II solution.
The function of 18 human kidney grafts was studied before and 3 months after autotransplantation without prior bench surgery on the parenchyma or the vessels. Kidney protection was accomplished by pre-treating the patient with mannitol and low molecular weight dextran solution and flushing the kidney with a Xylocaine-heparin mixture and cold Sacks' II solution. The mean cold ischaemia time was 239 min (range 140-345 min). The glomerular filtration rate (GFR) remained unchanged post-operatively in terms of both total and split kidney GFR. Proximal and distal tubular integrity, as studied by determination of beta2-microglobulin excretion and concentration ability respectively, was also preserved.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006982:Hypertonic Solutions; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D007684:Kidney Tubules / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D009994:Osmolar Concentration; D014182:Transplantation, Autologous; D014556:Urine
D006982:Hypertonic Solutions; C027821:Sack's solution; D003404:Creatinine