Effect of norethisterone enanthate on the blood count and endometrial histology of Indian women.
Endometrial histology and the haematological indices were studied in women receiving 200 mg of norethisterone enanthate (NET-EN) at 60-day intervals for 24 months as a method of contraception. Significant elevations occurred in the haemoglobin concentration and red blood cell counts during one year of therapy, while eosinophil counts showed a transient increase at 4 months of trial. The changes in the haematological indices seem to be due to stimulation of the erythropoietic system by NET-EN and may also be attributable to diminished blood loss due to amenorrhoea during the course of therapy. The endometrial histology revealed proliferative glands at 2 months which turned quiescent at 6-12 months of NET-EN therapy. Long-term use of 18 months showed atrophic changes with few glands, narrow lumina and stromal oedema.
D001773:Blood Cells / Q000166:cytology / Q000187:drug effects*; D002986:Clinical Trials as Topic; D003271:Contraceptive Agents, Female / Q000009:adverse effects*; D004717:Endometrium / Q000033:anatomy & histology* / Q000187:drug effects; D004804:Eosinophils / Q000166:cytology; D004906:Erythrocyte Count; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007267:Injections; D007958:Leukocyte Count; D009640:Norethindrone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D003271:Contraceptive Agents, Female; D006454:Hemoglobins; C024319:norethindrone enanthate; D009640:Norethindrone