[Chromosome analysis of female baboons following treatment with STS 557 and levonorgestrel].
Adult, female baboons (Papio hamadryas) were administered orally once 18 h p.c., either 1.6 mg STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4;9(10)-dien-3-one) or 1.6 mg levonorgestrel. Investigations of the bone-marrow cells of these animals showed, compared to untreated controls, no signs of increased chromosome aberrations caused by the substances. The relative frequency of chromosome aberrations were estimated for controls: STS 557: levonorgestrel with 0.60 +/- 0.35 : 0.55 +/- 0.39 : 0.92 +/- 0.46%, respectively. The differences between the three groups investigated in the exact Fisher-test (2 alpha = 0.05) were not significant.
D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology*; D010215:Papio / Q000235:genetics*; D045167:Progesterone Congeners / Q000494:pharmacology*; D013237:Stereoisomerism
D003277:Contraceptives, Oral, Combined; D003281:Contraceptives, Postcoital; D045167:Progesterone Congeners; D009644:Norgestrel; C023635:dienogest; D016912:Levonorgestrel; D009277:Nandrolone
Chromosomenanalytische Untersuchungen an weiblichen Pavianen nach Behandlung mit STS 557 und Levonorgestrel.