Synthesis of aldehydic peptides inhibiting renin.
Reduction of peptidyl N, O-dimethyl hydroxamates with lithium aluminium hydride in diethyl ether at 0 degree allowed the preparation of peptidyl aldehydes in excellent yield and optical purity. These aldehydic peptides are able to inhibit renin activity. They are the shortest renin inhibitors known to date.
D000447:Aldehydes / Q000138:chemical synthesis / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D000092502:Renin Inhibitors
D000447:Aldehydes; D007202:Indicators and Reagents; D009842:Oligopeptides; D000092502:Renin Inhibitors