[Modification of vigilance in the postanesthetic phase using physostigmine].
Physostigmine is an approved antidote in the treatment of intoxication as well as in the management of overdoses of numerous medications--many of which are used in the course of pre-medication or anesthesia induction or maintenance. In order to clarify whether or not physostigmine can accelerate the restoration of normal vigilance, a randomised, double-blind study of 60 patients was performed on the basis of 14 pre-determined vigilance criteria. The patients who received physostigmine demonstrated a significantly superior and more rapid restoration of consciousness as compared to the control group. Side-effects following administration were not observed. The results of our study indicate that post-anaesthesia administration of physostigmine appears useful in the treatment of certain types of patients.
D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D001143:Arousal / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010830:Physostigmine / Q000494:pharmacology*; D011184:Postoperative Period; D011897:Random Allocation; D013268:Stimulation, Chemical
D010830:Physostigmine
Zur Beeinflussung der Vigilanz in der postnarkotischen Phase durch Physostigmin.