A study of the effects of treating platelets with paraformaldehyde for use in the platelet suspension immunofluorescence test.
Discrepant results when paraformaldehyde (PFA) treated and untreated platelets were used in parallel in the platelet suspension immunofluorescence test (PSIFT) (von dem Borne et al, 1978) prompted further investigation of the sera of a group of patients suffering from chronic renal failure (CRF). The demonstration of a positive result in the PSIFT when only PFA treated platelets were used appears to be linked to the N like red cell antibody described in some patients suffering from CRF.
D001792:Blood Platelets / Q000187:drug effects* / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005557:Formaldehyde / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology; D008951:MNSs Blood-Group System / Q000276:immunology; D011108:Polymers / Q000494:pharmacology*
D008951:MNSs Blood-Group System; D011108:Polymers; D005557:Formaldehyde; C003043:paraform