Factor VIII related antigen in term and preterm newborns with severe neonatal haemorrhage.
Plasma factor VIII related antigen (VIIIR:Ag) concentrations were studied in term and preterm newborn infants. The control population was a group of normal children 2 to 12 years of age without any manifest disorder. The aim of the present investigation was to follow the change of VIIIR:Ag in the newborn and to study its level in sick preterm infants with severe bleeding disease. The VIIIR:Ag level in the control children was 86.2 +/- 20.5%. The lowest concentration was measured in term infants between 48-72 hours of life. The highest VIIIR:Ag level (129.1 +/- 8.1%) was found in those preterm newborns who died of pulmonary and intracranial bleeding in the early neonatal period. VIIIR:Ag is a useful marker of endothelial cell damage in the perinatal period.
D000941:Antigens / Q000032:analysis*; D001779:Blood Coagulation Factors / Q000032:analysis*; D002543:Cerebral Hemorrhage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005260:Female; D006470:Hemorrhage / Q000097:blood*; D006801:Humans; D007122:Immunoelectrophoresis; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood*; D008171:Lung Diseases / Q000097:blood*; D008297:Male; D014841:von Willebrand Factor / Q000032:analysis*
D000941:Antigens; D001779:Blood Coagulation Factors; D014841:von Willebrand Factor; D005169:Factor VIII