Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability.
In a placebo-controlled trial healthy volunteers and patients with hyperlipoproteinemias types II and IV received orally vitamin E at doses of 300 mg and 600 mg daily for 2 weeks. Serum tocopherol levels increased two-fold, but serum concentrations of total lipids, cholesterol, triglycerides, ceruloplasmin and transferrin remained unchanged. Dietary supplementation with vitamin E suppressed elevated concentrations of plasma lipid peroxides and this effect was correlated with an increase in serum antioxidant activity. In patients a mild platelet suppressant effect of vitamin E (600 mg daily) was observed. Feeding an atherogenic diet to rabbits for a week resulted in elevation of plasma lipid peroxides and a 90% decrease in arterial generation of prostacyclin. Enrichment of the atherogenic diet with 100 mg vitamin E daily prevented the increase in plasma lipid peroxides and protected the prostacyclin generating system in arteries. Thus, in hyperlipoproteinemias vitamin E corrects certain abnormalities of lipid metabolism which might predispose to atherosclerosis.
D000328:Adult; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010974:Platelet Aggregation; D011817:Rabbits; D013928:Thromboxane A2 / Q000097:blood; D014168:Transferrin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D008054:Lipid Peroxides; D014168:Transferrin; D014280:Triglycerides; D014810:Vitamin E; D013928:Thromboxane A2; D002784:Cholesterol; D011464:Epoprostenol; D002570:Ceruloplasmin; D010100:Oxygen