Structural study of a new antitumor antibiotic, kazusamycin.
The structure of a new antitumor antibiotic, kazusamycin produced by Streptomyces sp. No. 81-484, was determined on the basis of its spectral and chemical properties. Kazusamycin has a structure characteristic of an unsaturated, branched-chain fatty acid with a terminal delta-lactone ring.
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification; D007783:Lactones / Q000302:isolation & purification; D010443:Peptide Chain Termination, Translational; D013302:Streptomyces / Q000378:metabolism; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D005231:Fatty Acids, Unsaturated; D007783:Lactones; C042541:kazusamycin A