[Epidemiological trial of the prophylactic effectiveness of the interferon inducer dipyridamole with respect to influenza and acute respiratory diseases].
The epidemiological effectiveness of dipyridamol, an interferon-inducing agent used for the prevention of influenza and viral acute respiratory diseases, was tested in 4 epidemiological trials, 3 of them carried out as double blind trials. Observations were made in groups of adults (a research institute, a factory) and children (a kindergarten, a school), comprising 1040 subjects in the test groups and 771 subjects in the control groups. The drug was used during the whole epidemic period (January--March 1983) according to the following schedule: 1 oral administration in 8 days, in doses of 8 mg for adults, 50 mg for schoolchildren and 24 mg for children in the kindergarten. The epidemiological effectiveness of the drug was evaluated by comparing the total morbidity rates in influenza and acute respiratory diseases in the test and control groups. The results of 4 trials showed a pronounced epidemiological effectiveness of dipyridamol. The values of the epidemiological effectiveness index of the drug were 2.38 in the kindergarten, 1.55 at the school, 7.42 at the factory and 2.16 at the research institute. The results of the study of dipyridamol suggest that further investigations should be made with a view to use it for the mass prevention of influenza and acute respiratory diseases.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002031:Bulgaria; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004176:Dipyridamole / Q000627:therapeutic use*; D004196:Disease Outbreaks / Q000517:prevention & control*; D004311:Double-Blind Method; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D007369:Interferon Inducers; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D014505:Urban Population
D007369:Interferon Inducers; D004176:Dipyridamole
Epidemiologicheskoe ispytanie profilakticheskoĭ éffektivnosti induktora interferona dipiridamola v otnoshenii grippa i ostrykh respiratornykh zabolevaniĭ.