Pentagastrin-stimulated gastric acid output and plasma enteroglucagon in acarbose-treated rats.
Although the purified porcine enteroglucagons glicentin and oxyntomodulin inhibit pentagastrin-stimulated gastrin acid secretion when given parenterally to rats, it is not known whether the postprandial rise in endogenous enteroglucagons is capable of exerting a similar effect. We have used the alpha-glucosidase inhibitor acarbose in combination with a sucrose- and starch-rich semisynthetic diet over 8 days to bring about a mean increase of 89 pmol/l in the fasting plasma enteroglucagon concentration in rats, without significantly affecting plasma gastrin concentrations. There was no significant suppression of pentagastrin-stimulated gastric acid secretion in the acarbose-treated rats, suggesting that endogenous enteroglucagons do not act as physiological inhibitors of gastric acid secretion.
D020909:Acarbose; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D004763:Glucagon-Like Peptides / Q000097:blood* / Q000502:physiology; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D008297:Male; D053772:Oxyntomodulin; D010418:Pentagastrin / Q000494:pharmacology*; D010455:Peptides / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000494:pharmacology*
D005755:Gastrins; D005768:Gastrointestinal Hormones; D065089:Glycoside Hydrolase Inhibitors; D053772:Oxyntomodulin; D010455:Peptides; D014312:Trisaccharides; D004763:Glucagon-Like Peptides; C015236:glucagon-like-immunoreactivity; D005959:Glucosidases; D010418:Pentagastrin; D020909:Acarbose