Low skin temperatures produced by new skin refrigerants.
Temperatures produced by Cryosthesia -30 degrees C, Cryosthesia -60 degrees C, and Frigiderm were measured in minipigs. Cryosthesia -60 degrees C and Cryosthesia -30 degrees C were both found to rapidly lower skin temperatures to levels that have been shown to cause cell injury, necrosis, and loss of melanocytes. Use of these agents requires extreme caution in dermabrasion.
D000818:Animals; D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane / Q000494:pharmacology*; D003452:Cryosurgery / Q000379:methods; D003869:Dermabrasion / Q000379:methods; D004353:Drug Evaluation, Preclinical; D012881:Skin Temperature / Q000187:drug effects*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D064227:Chlorofluorocarbons, Ethane; D005617:Chlorofluorocarbons, Methane; C043995:Cryosthesia -30 C; C007783:Freon 114; C007782:dichlorodifluoromethane