Antimalarial agents. 1. alpha-Santonin-derived cyclic peroxide as potential antimalarial agent.
An alpha-santonin-derived cyclic peroxide (7) related to qinghaosu (1) has been synthesized and tested for antimalarial activity in vitro against the chloroquine-resistant (Smith) isolates of Plasmodium falciparum as well as in vivo against Plasmodium berghei in mice and was found to be devoid of activity.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010962:Plasmodium berghei; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D045787:Sesquiterpenes, Eudesmane
C047243:2,5-peroxy-6,11H-eudesm-3-en-6,13-olide; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D002738:Chloroquine