Oxidative and conjugative metabolism of diethylstilbestrol by rabbit preimplantation embryos.
Five- and six-day-old rabbit preimplantation embryos were found to be capable of metabolizing [3H]diethylstilbestrol (DES) in vitro. Based on the analysis of the metabolites formed during a 24-hr incubation period we conclude that these early stage embryos do have active monooxygenase and conjugative activity. The monooxygenase seems to be specific to this early stage of embryonic development.
D000818:Animals; D001711:Biotransformation; D001755:Blastocyst / Q000378:metabolism*; D004054:Diethylstilbestrol / Q000031:analogs & derivatives / Q000378:metabolism*; D005865:Gestational Age; D014453:Glucuronosyltransferase / Q000378:metabolism; D066298:In Vitro Techniques; D010105:Oxygenases / Q000378:metabolism; D011817:Rabbits; D013466:Sulfurtransferases / Q000378:metabolism
D004054:Diethylstilbestrol; D010105:Oxygenases; C045513:diethylstilbestrol monooxygenase; D014453:Glucuronosyltransferase; D013466:Sulfurtransferases