[Episode secretion of LH releasing hormone and LH in peripheral plasma of women with and without ovulatory disturbances].
We studied the secretory dynamics of plasma luteinizing hormone releasing hormone (LHRH) and luteinizing hormone (LH) in 5 normal ovulatory women during the early follicular phase, and 29 cases of ovuluatory disturbances using radioimmunoassay methods. All of the normal ovulatory women demonstrated one or two pulsatile LHRH releases in 3 or 4 hours. The height of LHRH secretory spikes was observed to be between 1.4 and 9.2 pg/ml. Plasma LH episodic secretion was related to LHRH episodic secretion. In 15 out of 27 cases of of ovulatory disturbances except cases with primary ovarian dysfunction, the LH episodic secretion revealed a significant decrease in pulse frequency. In 13 out of 16 cases of ovulatory disturbances, the height of LHRH secretory spikes was not greater than 1.3 pg/ml. This study indicates that the main causes of ovulatory disturbances are decrease in LHRH and LH episodic secretion. In all cases treated with clomphene, the plasma LHRH pulse increased after treatment. But in the cases where ovulation was not induced by clomiphene citrate, the plasma LH pulse did not increase as the LHRH pulse increased.
D000858:Anovulation / Q000378:metabolism*; D002996:Clomiphene / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D010060:Ovulation; D010902:Pituitary Gland / Q000378:metabolism
D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone