Epidermal and nerve growth factors manifest antilipolytic and lipogenic activities in isolated rat adipocytes.
The effects of epidermal growth factor (EGF) and nerve growth factor (NGF) from mouse submaxillary glands on lipolysis and lipogenesis in isolated rat adipocytes were studied. EGF and NGF at nanomolar concentrations augmented basal lipogenesis. The lipogenic responses to EGF and NGF were additive with a submaximal response induced by insulin but not with that of a maximal response to insulin, indicating a similarity in the mechanisms of action of EGF, NGF and insulin. EGF and NGF also inhibited epinephrine-induced lipolysis. The antilipolytic and lipogenic activities of EGF and NGF were considerably less potent by concentration than those of insulin.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008055:Lipids / Q000096:biosynthesis*; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland
D007328:Insulin; D008055:Lipids; D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor; D004837:Epinephrine