A protein cross-reacting immunohistochemically with rat glutathione S-transferase placental form as a marker for preneoplasia in Syrian hamster pancreatic and hepatocarcinogenesis.
Immunohistochemical staining using antirat glutathione S-transferase placental form (GST-P) rabbit antibody demonstrated marked binding to cells of putative preneoplastic lesions induced in both the liver and pancreas of Syrian hamsters by dihydroxy-di-n-propylnitrosamine treatment, whereas background normal-appearing tissue was negative. Thus, a protein showing immunological cross-reaction with rat GST-P is also elevated during pancreatic carcinogenesis and hepatocarcinogenesis in the hamster, suggesting its usefulness as a marker with potential relevance to the mechanisms underlying the neoplastic process.
D000818:Animals; D006224:Cricetinae; D005260:Female; D005982:Glutathione Transferase / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008114:Liver Neoplasms, Experimental / Q000032:analysis / Q000473:pathology*; D008297:Male; D008647:Mesocricetus; D009363:Neoplasm Proteins / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000032:analysis / Q000473:pathology*; D010920:Placenta / Q000201:enzymology*; D011230:Precancerous Conditions / Q000032:analysis / Q000473:pathology*; D011247:Pregnancy; D051381:Rats
D009363:Neoplasm Proteins; D005982:Glutathione Transferase