Decreased serum reverse triiodothyronine levels with major weight loss in obese women.
Anorexia nervosa is accompanied by increased serum reverse triiodothyronine levels and decreased serum triiodothyronine levels. We observed 28 women undergoing gastric plication for morbid obesity and found serum reverse triiodothyronine levels to be significantly decreased (p = 0.018) from a preoperative mean (+/- SD) of 0.30 (+/- 0.17) to 0.21 (+/- 0.06) ng/ml after weight loss. As all of our subjects were on semistarvation diets and had a significant weight loss (p less than 0.001), the observed decrease in reverse triiodothyronine rather than increase (as reported in anorexia nervosa) suggests factors other than weight loss or a semistarvation diet are important in the reverse triiodothyronine increase observed in anorexia nervosa.
D000328:Adult; D001835:Body Weight; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000601:surgery; D012709:Serum Albumin / Q000032:analysis; D013270:Stomach / Q000601:surgery; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000032:analysis; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood*
D012709:Serum Albumin; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D013974:Thyroxine