[Quantitative and functional evaluation of immunoregulating cells and natural killers in patients with aplastic anemia].
Cell-mediated immunity was studied in 11 patients with idiopathic aplastic anemia according to several parameters at a time. Analysis of the data obtained draws attention to the pronounced relative lymphocytosis, disordered balance of the immunoregulatory subpopulations of T lymphocytes (T mu and T gamma) associated with an appreciable increase in the number of cytotoxic T suppressor cells. The lowering of spontaneous and optimal Con A dose-induced production of leukocyte migration inhibition factor and deficiency of the activity of normal killers can be determined by potentiation of the suppressor activity of T lymphocytes or by the influence of factors produced by T suppressors. The goal-oriented correction of the high suppressor activity of T cells may appear promising in the complex of therapeutic measures used in the management of the patients' population with idiopathic aplastic anemia.
D000741:Anemia, Aplastic / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002464:Cell Migration Inhibition; D006801:Humans; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology*; D007958:Leukocyte Count; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D007961:Leukocyte Migration-Inhibitory Factors
Kolichestvennaia i funktsionalnaia otsenka immunoreguliatornykh kletok i estestvennykh killerov u bol'nykh aplasticheskoĭ anemieĭ.