Role of pharmacokinetics and DNA dosimetry in relating in vitro to in vivo actions of N-nitroso compounds.
D000818:Animals; D001711:Biotransformation; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002927:Cimetidine / Q000031:analogs & derivatives / Q000633:toxicity; D004273:DNA, Neoplasm / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D009154:Mutation / Q000187:drug effects*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity; D009603:Nitroso Compounds / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D004273:DNA, Neoplasm; D009602:Nitrosamines; D009603:Nitroso Compounds; C019503:nitrosocimetidine; D002927:Cimetidine; C010259:nitrosoproline