Common evolutionary origin of the phage T4 dam and host Escherichia coli dam DNA-adenine methyltransferase genes.
We compared the known DNA nucleotide and encoded amino acid sequences of the Escherichia coli and bacteriophage T4 dam (DNA-adenine methyltransferase) genes. Despite the absence of any DNA sequence homology, there were four regions (11 to 33 residues long) of amino acid sequence homology containing 45 to 64% identity. These results suggest that the genes for these two enzymes have a common evolutionary origin.
D000225:Adenine / Q000032:analysis; D000595:Amino Acid Sequence; D001482:Base Composition; D005075:Biological Evolution; D003062:Codon; D004269:DNA, Bacterial / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005798:Genes, Bacterial; D005814:Genes, Viral; D008780:Methyltransferases / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D013604:T-Phages / Q000201:enzymology / Q000235:genetics*; D013941:Thymine / Q000032:analysis
D003062:Codon; D004269:DNA, Bacterial; D004279:DNA, Viral; D008780:Methyltransferases; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D000225:Adenine; D013941:Thymine