Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.
We report the case of a 59-year-old man who was treated with intraarterial chemotherapy for metastatic colonic adenocarcinoma. After the second course he developed persistent symptoms of nausea, vomiting, and pain. Endoscopic examination demonstrated severe erosive gastritis and duodenitis, and histological examination of the antral tissue showed severe atypia and histological appearances suggestive of in situ carcinoma. A 2-month course of sucralfate and cimetidine was used and successfully produced symptomatic relief as well as complete normalization of the dysplastic changes.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000535:Aluminum / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects* / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D013392:Sucralfate
D008937:Mitomycins; D016685:Mitomycin; D013392:Sucralfate; D002927:Cimetidine; D000535:Aluminum; D005472:Fluorouracil