Carcinogenic N-hydroxylaminopurine derivatives do not act as base analog mutagens in Salmonella typhimurium.
N-Hydroxylaminopurines are highly mutagenic for growing as well as resting Salmonella typhimurium strain TA100 and to a lesser extent for strain TA98. Aminopurines, under similar conditions, are not mutagenic. N-Methylhydroxylaminopurine, under similar conditions, exhibits only minimal activity. The results are taken to indicate that unlike non-hydroxylated aminopurines, N-hydroxylaminopurines exert their mutagenicity not by acting as base analogs but by direct covalent binding with DNA-guanine.
D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism; D002273:Carcinogens; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D002273:Carcinogens; D011687:Purines; C032610:6-N-hydroxylaminopurine; D004247:DNA; D000225:Adenine