The incidence of naturally-occurring primary brain tumours in the laboratory rat.
Histological analysis of 90 spontaneous primary tumours of the brain observed among 8960 ageing rats (Sprague-Dawley-derived) revealed 55 granular-cell meningiomas, 19 neoplastic reticuloses, 11 neuroglial tumours, 4 pineal tumours, and one pleomorphic, meningeal sarcoma. Although all these tumour types can occur in man and other animal species, the high incidence of granular-cell tumours, and the low degree of differentiation of some neuroglial and pineal tumours, appear to be characteristic attributes of the rat.
D000818:Animals; D001254:Astrocytoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D001932:Brain Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005910:Glioma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D008297:Male; D008579:Meningioma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D009837:Oligodendroglioma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D010871:Pinealoma / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000453:epidemiology* / Q000473:pathology