An albumin dimer in urine.
An albumin dimer (approximately 134 000 Da) was present, along with monomeric albumin, in freshly voided urine but not in serum from a 53-year-old man with alcoholic liver disease and chronic renal failure. The dimerization, evidently via disulfide bonds, resulted in a loss of [125I]thyroxin-binding capacity. This suggests that the S--S bridging is at a site different from that previously reported. The dimer was unstable at all storage temperatures studied.
D000418:Albumins; D000419:Albuminuria / Q000652:urine*; D001345:Autoradiography; D004587:Electrophoresis, Agar Gel; D004588:Electrophoresis, Cellulose Acetate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000652:urine; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000652:urine; D008297:Male; D008623:Mercaptoethanol; D008875:Middle Aged; D008970:Molecular Weight; D013975:Thyroxine-Binding Proteins
D000418:Albumins; D013975:Thyroxine-Binding Proteins; C030764:bisalbumins; D008623:Mercaptoethanol