The value of Tc-DTPA transit times and NMR T1 measurements in monitoring the progress of renal transplants.
The value of 99Tcm-DPTA transit times and NMR T1 measurements in monitoring the progress of renal transplants has been investigated. Renal transit times were calculated from 182 renograms performed on 29 patients and from 22 of these patients 67 proton spin-lattice relaxation time (T1) measurements were obtained using the Aberdeen Mk 2 NMR Imager. The clinical status of each patient at the time of investigation was defined in retrospect. The principal value of the mean transit time (MTT) was in differentiating between acute rejection and other causes of raised plasma creatinine. During a rejection episode the MTT is raised out of the normal range of 227 +/- 26 s but with chronic rejection or other causes of raised plasma creatinine the MTT remains within normal limits. NMR T1 values appeared to be of little diagnostic value as the normal range was found to be very wide ranging from 340 to 640 ms.
D003404:Creatinine / Q000097:blood; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism; D016030:Kidney Transplantation; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011866:Radioisotope Renography; D016284:Technetium Tc 99m Pentetate
D009942:Organometallic Compounds; D004369:Pentetic Acid; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate