[Incidence of spina bifida occulta in relatives of children with myelodysplasia. Indications for high-risk screening].
Consanguineous relatives (parents, siblings) of patients with myelodysplasia show an increased incidence of spina bifida occulta compared to a normal population. According to this and considering the obvious familiarity of neural tube defects, in all cases of a spina bifida occulta known in relatives a high-risk-screening (AFP, B-scan ultrasound) should be performed during early pregnancy. Patients with a spina bifida occulta should be informed about their anomaly and in case of pregnancy instruct the obstetrician to provide a careful screening examination.
D000328:Adult; D000757:Anencephaly / Q000235:genetics; D005260:Female; D006580:Genetic Carrier Screening; D005859:Germany, East; D006801:Humans; D006849:Hydrocephalus / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D008423:Maternal Age; D008591:Meningomyelocele / Q000235:genetics; D010298:Parity; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012306:Risk; D016136:Spina Bifida Occulta / Q000235:genetics*
Inzidenz der Spina bifida occulta bei Angehörigen von Kindern mit Myelodysplasie. Indikationen zum High-risk-Screening.