An autopsy case of prolidase deficiency.
A 25-year-old female who suffered from longstanding incurable leg ulcers was found to have prolidase deficiency with iminodipeptiduria. On ultrastructural studies of autopsy specimens, the lamina densa of the epidermal basement membrane was found to show irregular splitting and the basement membranes of the dermal blood vessels were lamellated with interruptions. Lamellar changes and splitting of the basement membranes of the renal tubules, interstitial blood vessels and glomerular capillaries also occurred. These morphological abnormalities seem to be one of causes of the clinical symptomatology.
D000328:Adult; D000682:Amyloid / Q000032:analysis; D001485:Basement Membrane / Q000473:pathology; D004150:Dipeptidases / Q000172:deficiency*; D004151:Dipeptides / Q000652:urine; D005260:Female; D006801:Humans; D007097:Imines / Q000652:urine; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D007871:Leg Ulcer / Q000209:etiology / Q000473:pathology; D012867:Skin / Q000098:blood supply / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy; D016038:Skin Transplantation
D000682:Amyloid; D004151:Dipeptides; D007097:Imines; D004150:Dipeptidases; C022449:proline dipeptidase