Prevention of intraventricular haemorrhage by fresh frozen plasma.
Seventy three preterm infants weighing less than 1500 g or less than 32 weeks' gestation, or both, were allocated randomly to treatment (fresh frozen plasma 10 ml/kg on admission and at 24 hours of age) or control groups. Fifteen (41%) out of 37 control patients sustained intraventricular haemorrhage compared with five (14%) of 36 patients receiving treatment (X2 = 5.24, P = 0.022). No difference was found in coagulation factors measured at birth or at 48 hours of age in both groups. Fresh frozen plasma appears to have a beneficial effect in the prevention of intraventricular haemorrhage.
D001777:Blood Coagulation; D001803:Blood Transfusion; D002543:Cerebral Hemorrhage / Q000097:blood / Q000517:prevention & control*; D002552:Cerebral Ventricles; D002986:Clinical Trials as Topic; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D010949:Plasma; D011446:Prospective Studies; D011897:Random Allocation