Third-line therapy. A cautionary note.
Ten patients who failed to achieve a satisfactory blood pressure level with dual therapy of a diuretic and a beta-blocker were allocated to captopril, nifedipine and methyldopa in random order as third-line therapy. Four patients failed to respond to any third-line agent; one patient responded to all three agents, two to nifedipine and captopril and one only to captopril. Third-line therapy is frequently ineffective and several agents may have to be tried to achieve an adequate response.
D001262:Atenolol / Q000627:therapeutic use; D001539:Bendroflumethiazide / Q000627:therapeutic use; D002216:Captopril / Q000627:therapeutic use*; D002752:Chlorthalidone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use*; D009543:Nifedipine / Q000627:therapeutic use*
D001262:Atenolol; D008750:Methyldopa; D001539:Bendroflumethiazide; D002216:Captopril; D009543:Nifedipine; D002752:Chlorthalidone