Presence of an estrogen-regulated protein in endometrial cancer.
The presence of an estrogen-regulated protein of Mr 24,000 (24K) was studied in 43 patients diagnosed as having endometrial adenocarcinoma. using an anti-24K monoclonal antibody, a modified immunoperoxidase system (avidinbiotin complex) was used to detect the presence of 24K in formalin-fixed, paraffin-embedded tissue samples. The positivity for 24K was correlated with low tumor histologic grade, few mitotic figures, few nucleoli, and a low degree of nuclear pleomorphism. These data suggest that 24K may be a potential marker of tumor differentiation.
D000230:Adenocarcinoma / Q000032:analysis / Q000473:pathology; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000032:analysis / Q000473:pathology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D008940:Mitotic Index; D008970:Molecular Weight; D009367:Neoplasm Staging; D011960:Receptors, Estrogen / Q000032:analysis*; D014594:Uterine Neoplasms / Q000032:analysis* / Q000473:pathology
D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen