Frameshift mutagenicity of dinitrobenzene derivatives on Salmonella typhimurium TA98 and Tm elevation of calf thymus DNA by dinitrobenzene derivatives.
1-Chloro-2,4-dinitrobenzene and m-dinitrobenzene were mutagenic on Salmonella typhimurium TA98 without S-9mix. But 1-substituted-2,4-dinitrobenzene derivatives which substituted by electron releasing groups such as OH-, NH2- or CH3- did not show mutagenicity on Salmonella typhimurium TA98 without S-9mix. Tm of calf thymus DNA was elevated by addition of m-dinitrobenzene or 1-chloro-2,4-dinitrobenzene, and falled by addition of 1-substituted-2,4-dinitrobenzenes which substituted by electron releasing substituents such as OH-, NH2- or CH3- groups. The mutagenic dinitrobenzene derivatives such as 1-chloro-2,4-dinitrobenzene showed the special changes in the difference spectra about four bases of the DNA and this compound.
D000818:Animals; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D004136:Dinitrobenzenes / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D009578:Nitrobenzenes / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D013950:Thymus Gland
D004136:Dinitrobenzenes; D009153:Mutagens; D009578:Nitrobenzenes; D004247:DNA