The growth of single crystal and the determination of crystallographic parameters of (L-tryptophan)A1-insulin and (D-tryptophan)A1-insulin.
The crystal-growing conditions and the results of preliminary X-ray crystallographic analysis of (L-Try)A1-insulin and (D-Try)A1-insulin are reported. The single crystals of this pair of insulin analogue suitable for X-ray diffraction analysis have been grown in the citrate buffer system by still-setting method. They both belong to the trigonal system with space group R3. The parameters of the unit cell (L-Trp)A1-insulin are aH = 80.31A, cH = 37.45A and those of (D-Trp)A1-insulin aH = 79.48A, cH = 43.81A. There are two molecules in an asymmetric unit. The obtained results are discussed.
D003461:Crystallography; D007328:Insulin / Q000031:analogs & derivatives* / Q000032:analysis; D011972:Receptor, Insulin / Q000187:drug effects; D013329:Structure-Activity Relationship
D007328:Insulin; C049598:insulin, Trp(A1)-; D011972:Receptor, Insulin