Rapid correction of red-cell nucleotide abnormalities following successful renal transplantation.
Erythrocyte levels of 5' mono-, di- and triphosphates of adenosine, inosine and guanosine, together with NAD+ (H) and NADP+ (H) were measured before and serially after renal transplantation. The high levels of ATP and guanosine triphosphate (GTP) fell to normal within 3 d of achieving a normal plasma creatinine. The decline in ATP and GTP levels paralleled the fall in plasma creatinine. Acute graft rejection was accompanied by a rise in ATP and GTP, both of which returned rapidly to normal with resolution of the rejection episode. Radiolabelling of red cells confirmed that the metabolism of the existing red-cell population was corrected so that observed changes in nucleotide concentrations were not due to a new cohort of cells.
D000328:Adult; D003401:Creatine / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006084:Graft Rejection; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D016030:Kidney Transplantation; D008297:Male; D010710:Phosphates / Q000097:blood; D011184:Postoperative Period; D011685:Purine Nucleotides / Q000097:blood*
D006454:Hemoglobins; D010710:Phosphates; D011685:Purine Nucleotides; D003401:Creatine