Stability of ribosomal protein mRNA and translational feedback regulation in Escherichia coli.
It was previously observed that the stability of ribosomal protein (r-protein) mRNA in Escherichia coli decreases under the conditions where its translation is feedback inhibited by repressor r-protein. We have now demonstrated that the stability of mRNA for r-proteins S13, S11 and S4 increases in a strain carrying a mutation in the gene for S4, a translational repressor regulating these r-proteins. The results confirm the previous observations that translational repression increases the decay rate of r-protein mRNA, and in addition, show that the half-life of S13-S4 r-protein mRNA in cells growing under ordinary conditions is significantly shorter than its inherent stability would predict, due to the operation of translational feedback regulation.
D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D005246:Feedback; D007700:Kinetics; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics*; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000235:genetics*
D012333:RNA, Messenger; D012269:Ribosomal Proteins