Ribosome-SRP-signal sequence interactions. The relay helix hypothesis.
The role of the signal sequence in protein export is reviewed, and some difficulties inherent in the conventional picture of how it interacts with other components of the export machinery are pointed out. An alternative model is suggested, which seems to account better for some of the critical experimental findings made so far.
D000595:Amino Acid Sequence; D001692:Biological Transport; D008565:Membrane Proteins / Q000378:metabolism; D008956:Models, Chemical; D009154:Mutation; D011485:Protein Binding; D014176:Protein Biosynthesis; D011487:Protein Conformation; D021382:Protein Sorting Signals / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
D008565:Membrane Proteins; D021382:Protein Sorting Signals; D011506:Proteins