Caerulein and its analogues: neuropharmacological properties.
The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and water; antinociception; sedation; catalepsy; ptosis, antistereotypic, anticonvulsive and tremorolytic effects; inhibition of self-stimulation. Effects of CER in man comprise sedation, satiety, changes in mood, analgesia and antipsychotic effects. A modulation of central dopaminergic functions appears to be one possible mechanism of CER and its analogues. A common denominator for all effects of CER is, at present, not evident.
D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001763:Blepharoptosis / Q000139:chemically induced; D001833:Body Temperature Regulation / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D002108:Ceruletide / Q000031:analogs & derivatives / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D004594:Electrophysiology; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives; D009043:Motor Activity / Q000187:drug effects; D010146:Pain / Q000503:physiopathology; D011618:Psychotic Disorders / Q000188:drug therapy; D012653:Self Stimulation / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship; D019966:Substance-Related Disorders / Q000503:physiopathology; D014202:Tremor / Q000503:physiopathology
D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D002108:Ceruletide