A comparative trial of metronidazole v. tinidazole in the treatment of amoebic liver abscess.
Forty-eight patients were treated for amoebic liver abscess, 27 with metronidazole (Flagyl; Maybaker) and 21 with tinidazole (Fasigyn; Pfizer). Although 4 patients treated with tinidazole and 2 treated with metronidazole required a second course of therapy, both drugs were highly effective and resulted in rapid clinical improvement. The only side-effect was oral candidiasis, which developed in 2 patients in each drug group.
D000328:Adult; D002986:Clinical Trials as Topic; D006801:Humans; D008101:Liver Abscess, Amebic / Q000188:drug therapy*; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011897:Random Allocation; D014011:Tinidazole / Q000008:administration & dosage / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole