Tumor promoter phorbol esters induce unresponsiveness to antigen and expression of interleukin 2 receptor on T cells.
The tumor promoter 12-O-tetradecanoylphorbol 13-acetate induces the expression of the interleukin 2 receptor and the disappearance of the T3 complex in a T cell hybridoma, T cell clones, thymic and peripheral T cells and T cell tumors. These changes are accompanied by an increased sensitivity to interleukin 2 and antigen-specific unresponsiveness in T cell clones.
D000911:Antibodies, Monoclonal; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D010704:Phorbols / Q000494:pharmacology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D011971:Receptors, Immunologic / Q000187:drug effects*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D010704:Phorbols; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D013755:Tetradecanoylphorbol Acetate