Field studies on sugar substitutes.
Four field studies assessing the caries preventive value of partial substitution of sucrose by xylitol or a mixture of xylitol and sorbitol were recently conducted. The trials (in Thailand, Hungary and two in French Polynesia) had certain common features, i.e. protocols approved by the WHO; low intake of polyol(s); non-randomized young study populations, differing baseline caries prevalences between groups; and planned duration of 32-36 months. Analysis of the findings was facilitated through the use of rates to measure caries increments expressed as DMF teeth and surface counts in relation to the numbers of teeth at risk. Irrespective of baseline differences, all studies revealed, in comparison to known methods, that partial substitution of sucrose was associated with a preventive effect.
D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D006814:Hungary; D009067:Mouthwashes; D011114:Polynesia; D013012:Sorbitol / Q000008:administration & dosage / Q000494:pharmacology; D013549:Sweetening Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013785:Thailand; D014993:Xylitol / Q000008:administration & dosage / Q000494:pharmacology
D009067:Mouthwashes; D013549:Sweetening Agents; D013012:Sorbitol; D005459:Fluorides; D014993:Xylitol