[Behavior of the concentration of triiodothyronine, thyroxine, thyrotropin and thyroxine-binding globulin in the serum of children with nephrotic syndrome].
Concentrations of triiodothyronine, thyroxine, thyrotropin, thyroxine-binding globulin, urea, creatinine, cholesterol and total protein were determined in serum of six children (ages from 4 to 16 years) with nephrotic syndrome undergoing therapy. The results showed that with decreasing concentration of serum protein and increasing concentration of cholesterol the concentrations of thyroxine and thyroxine-binding globulin decreased whereas the concentration of thyrotropin was elevated. Improvement in the concentration of serum protein lead to an improvement of serum levels of thyroid hormones and thyroxine-binding globulin; concentrations of thyrotropin and cholesterol returned to values close to normal. Although triiodothyronine was decreased slightly it remained in the normal range thus preventing overt hypothyroidism.
D000293:Adolescent; D001798:Blood Proteins / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*; D013975:Thyroxine-Binding Proteins / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood*
D001798:Blood Proteins; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D002784:Cholesterol; D003404:Creatinine; D013974:Thyroxine
Verhalten der Konzentration von Trijodthyronin, Thyroxin, Thyreotropin und thyroxin-bindendem Globulin im Serum von Kindern mit nephrotischem Syndrom.