[Stability of tissue plasminogen activator].
Stability of the tissue activator plasminogen was studied in various experimental conditions in vitro. The enzyme did not loss its activity after 3 hrs incubation and 7-fold dilution with physiological saline. Blood plasma, added to the tissue activator plasminogen preparation, decreased twice the enzyme activity even without preincubation. In blood plasma, obtained within 1 min after intravenous administration of the activator preparation, inhibition of the enzyme occurred during all the period of incubation and it was more pronounced.
D000818:Animals; D001780:Blood Coagulation Tests; D004355:Drug Stability; D066298:In Vitro Techniques; D009206:Myocardium / Q000032:analysis; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors* / Q000097:blood / Q000302:isolation & purification; D015849:Plasminogen Inactivators; D051381:Rats; D013552:Swine
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators
Stabil'nost' tkanevogo aktivatora plazminogena.