Alcohol interactions with typical and atypical antidepressants.
Selected parameters of central nervous system function have been examined in rabbits and mice given ethyl alcohol (ET) in combination with antidepressant drugs with different pharmacological profiles. A significant prolongation of the ET-induced loss of righting reflex was observed in mice treated with amitriptyline, 3 mg/kg, or trazodone, 8 mg/kg, injected intraperitoneally. The same drugs failed to cause narcosis when given alone to mice at doses up to 40 (amitriptyline) and 100 (trazodone) mg/kg. Rabbits given single 5 mg/kg IV doses of amitriptyline or trazodone exhibited a synchronous EEG pattern with an increase in spectrum total power that became more pronounced after IV injection of a low dose of ET (0.2 g/kg). The increase in the spectrum total power after ET was significantly greater in rabbits given trazodone than in those given amitriptyline. No significant interactive effects were observed in animals receiving combinations of ET with viloxazine, bupropion or fluvoxamine.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D016642:Bupropion; D004347:Drug Interactions; D004569:Electroencephalography; D000431:Ethanol / Q000008:administration & dosage*; D016666:Fluvoxamine; D008297:Male; D051379:Mice; D010091:Oximes / Q000008:administration & dosage; D011427:Propiophenones / Q000008:administration & dosage; D011817:Rabbits; D051381:Rats; D012890:Sleep / Q000187:drug effects; D014196:Trazodone / Q000008:administration & dosage; D014745:Viloxazine / Q000008:administration & dosage
D000928:Antidepressive Agents; D010091:Oximes; D011427:Propiophenones; D016642:Bupropion; D000431:Ethanol; D014745:Viloxazine; D016666:Fluvoxamine; D014196:Trazodone