[Effect of serotonin on the yield of UV- and x ray-induced DNA damage].
Using two-dimensional thin-layer chromatography, the effect of serotonin on the yield of thymine dimers and on cleavage of the N-glycosidic bond in the DNA irradiated with ultraviolet (UV) light and X-ray was studied. Bound serotonin was shown to reduce the synthesis of UV-induced thymine dimers but had no effect on the number of X-ray-induced breaks in the N-glycoside bonds in thymidine residues. The data obtained are discussed in terms of the mechanisms of serotonin involvement in the photoprotection of yeast cells from the lethal action of UV and X-ray irradiations.
D004269:DNA, Bacterial / Q000378:metabolism / Q000528:radiation effects*; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D010777:Photochemistry; D011740:Pyrimidine Dimers / Q000528:radiation effects; D011837:Radiation-Protective Agents; D012701:Serotonin / Q000494:pharmacology*; D014466:Ultraviolet Rays; D014965:X-Rays
D004269:DNA, Bacterial; D011740:Pyrimidine Dimers; D011837:Radiation-Protective Agents; D012701:Serotonin
Vliianie serotonina na doliu indutsirovannykh ul'trafioletovym svetom i rentgenovskim oblucheniem povrezhdeniĭ v DNK.