[Yield of the thoracoscopic biopsy in experimental pulmonary infections in the immunosuppressed rabbit].
Using thoracoscopy lung biopsy we investigated the bacteriological diagnostic yield in immunodepressed and/or infected NZ rabbits. 84 rabbits were used: 18 controls, 30 immunodepressed rabbits and 36 rabbits immunodepressed and then infected with Aspergillus fumigatus. Candida albicans or B.C.G. The thoracoscopy technique was the one we designed for humans, the instruments were adapted to the size of animals. Thoracoscopy biopsy results were compared to those of surgical biopsies made in the same animals. The results of both techniques were similar: indeed, the sensitivity of thoracoscopy biopsy was 88.9% in immunodepressed rabbits (versus 100% with surgical biopsies), 86% in the group of rabbits infected with B.C.G. (versus 86%), 90.1% in rabbits infected with Aspergillus fumigatus (versus 100%) and 88.9% in rabbits infected with Candida albicans (versus 100%). The indications for thoracoscopic lung biopsy in immunodepressed patients with infectious lung diseases are drawn from these experimental data, from our experience and the known mortality and morbidity of surgical lung biopsy.
D000818:Animals; D001228:Aspergillosis / Q000276:immunology*; D001431:Bacteriological Techniques; D001706:Biopsy / Q000379:methods; D002177:Candidiasis / Q000276:immunology*; D007165:Immunosuppression Therapy; D008168:Lung / Q000473:pathology; D009163:Mycobacterium bovis; D011014:Pneumonia / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D011817:Rabbits; D013906:Thoracoscopy
Rendement de la biopsie thoracoscopique dans les infections pulmonaires expérimentales chez le lapin immunodéprimé.