Generalized pustular psoriasis provoked by propranolol.
An 80-year-old man who had had plaque-type psoriasis for 40 years experienced a rapid onset of generalized pustular psoriasis three days after initiation of propranolol hydrochloride therapy. Trial therapy with propranolol on two occasions resulted in similar episodes. The skin lesions and systemic symptoms resolved after the discontinuation of propranolol therapy and administration of methotrexate sodium. This case study documents propranolol--a beta-blocker--as another causal factor for pustular psoriasis.
D000368:Aged; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011433:Propranolol / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced* / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D014202:Tremor / Q000188:drug therapy
D011433:Propranolol; D008727:Methotrexate