[The study of urinary tract infection with a possible cause of fungi and evaluation of the efficacy of 5-FC].
Prior to clinical investigations, in vitro activities of 5-fluorocytosine (5-FC), ofloxacin (OFLX), and the combination on a strain of E. coli and of C. albicans were tested. The two drugs showed highly active on each target strain without any interaction. In clinical studies, 5 female adult patients with persistent uncomplicated UTI (3 of cystitis, 2 of pyelonephritis) caused by polymicrobial organisms (including bacteria and fungi) were treated in combination of 5-FC and oral chemotherapeutic agent. The results were both bacteriologically and symptomatically successful in all of 5 cases. Those had been poor by other antibiotic drugs in single use or 5-FC alone. Consequently, 5-FC and oral antibacterial drug combination was useful in therapy on even uncomplicated UTI due to polymicrobial organisms including fungi.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D003596:Cytosine / Q000031:analogs & derivatives*; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010078:Oxazines; D003596:Cytosine; D015242:Ofloxacin; D005437:Flucytosine