Serum carbonic anhydrase III in progressive muscular dystrophy.
Serum carbonic anhydrase III (CA-III) levels were determined by means of an enzyme immunoassay method and compared with serum creatine kinase (CK) and muscle-specific enolase (MSE) levels in 143 patients with four types of progressive muscular dystrophy (PMD), namely, Duchenne muscular dystrophy (DMD), limb-girdle dystrophy, facioscapulohumeral dystrophy and congenital dystrophy. Serum CA-III levels were raised in the majority of patients, especially in those with DMD. In DMD patients, the gradual decline in the CA-III level was observed with age. High correlations were found between CA-III, CK and MSE levels. The frequency of cases with elevated CA-III levels was the same as or greater than that of elevated CK or MSE levels in four types of PMD. These results suggest that serum CA-III may be a useful marker of muscle disease.
D000293:Adolescent; D000328:Adult; D002256:Carbonic Anhydrases / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology; D009136:Muscular Dystrophies / Q000201:enzymology*; D009928:Organ Specificity; D010751:Phosphopyruvate Hydratase / Q000097:blood; D013577:Syndrome
D007527:Isoenzymes; D003402:Creatine Kinase; D002256:Carbonic Anhydrases; D010751:Phosphopyruvate Hydratase