Specific prolactin release refractoriness to thyroid-stimulating hormone-releasing factor in an obese infertile man.
A specific PRL unresponsiveness to TSH-releasing factor was uncovered during the workup of an obese man with infertility due to oligozoospermia. Normal PRL responses were demonstrated in response to insulin-induced hypoglycemia, MTC, and sleep. Borderline-low circulating T without elevated baseline LH levels which rose in response to clomiphene citrate and normal LH and FSH responses were noted after LH-RH administration, indicating normal pituitary responsiveness, even though occurring in the presence of hypothalamic dysfunction, affecting pituitary gonadal relations, appears located in the pituitary and limited to a single stimulus: TSH-releasing factor.
D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism; D007248:Infertility, Male / Q000097:blood* / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008787:Metoclopramide; D009765:Obesity / Q000097:blood*; D009845:Oligospermia / Q000150:complications; D011388:Prolactin / Q000097:blood*; D012890:Sleep / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D008787:Metoclopramide; D006854:Hydrocortisone