Comparison of cyclothiazide and hydrochlorthiazide in hypertension. Effects of different doses of diuretics.
In a group of 12 hypertensive outpatients, randomized double-blind cross-over comparison of the antihypertensive effect of various doses of cyclothiazide and hydrochlorthiazide revealed that 2.5 mg of cyclothiazide daily or 25 mg of hydrochlorthiazide daily have an equal antihypertensive effect. Increasing the dose of either diuretic did not further reduce the blood pressure.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001581:Benzothiadiazines / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004573:Electrolytes / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D001786:Blood Glucose; D004573:Electrolytes; D006852:Hydrochlorothiazide; D014527:Uric Acid; C004639:cyclothiazide