Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse.
We have determined the DNA sequence of a gene encoding a thymus leukemia (TL) antigen in the BALB/c mouse, and have more definitively mapped the cloned BALB/c Tla-region class I gene clusters. Analysis of the sequence shows that the Tla gene is less closely related to the H-2 genes than H-2 genes are to one another or to a Qa-2,3-region genes. The Tla gene, 17.3A, contains an apparent gene conversion. Comparison of the BALB/c Tla genes with those from C57BL shows that BALB/c has more Tla-region class I genes, and that one of the genes absent in C57BL is gene 17.3A.
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005785:Gene Conversion; D005796:Genes; D008040:Genetic Linkage; D008285:Major Histocompatibility Complex; D008562:Membrane Glycoproteins; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D011110:Polymorphism, Genetic
D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens; D004247:DNA