The effect of intravenous prostaglandin E1 on ischaemic pain and on leg blood-flow in subjects with peripheral artery disease: a double-blind controlled study.
The effect of intravenous PGE1 (15 micrograms/h for 72 h) and saline (placebo) on ischaemic resting pains and the macro- and microcirculation was studied in 16 patients with peripheral artery disease. No significant difference in pain relief was observed between PGE1 and placebo. The calf blood-flow was unchanged during both infusions. Skin temperature in the arteriosclerotic foot, however, increased significantly during PGE1 infusion but not during saline infusion. No significant effects were seen on blood-pressure, fluorescein angiography or vital capillary microscopy of the big toe 1 week or 1 month after the PGE1 and placebo infusions.
D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use*; D000700:Analgesics; D001794:Blood Pressure; D002196:Capillaries / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007511:Ischemia / Q000628:therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D012881:Skin Temperature
D000700:Analgesics; D000527:Alprostadil