[Transport of antibiotics to the endocardium following administration into the pericardial cavity--experimental study].
After injection of diverse antibiotics (penicillin G, tetracycline, cephalosporin) into the pericardial cavity of miniature swine higher antimicrobial activities in the subendocardial layers (mitral valve) were observed than after the intravenous application. Additional experimental studies should succeed these preliminary results. The intrapericardial application could be discussed than as a last measure in conservative treatment of the therapy-resistant endocarditis.
D000042:Absorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism; D004699:Endocardium / Q000378:metabolism*; D005260:Female; D007267:Injections; D008297:Male; D010400:Penicillin G / Q000378:metabolism; D010496:Pericardium / Q000378:metabolism*; D013552:Swine; D013556:Swine, Miniature; D013752:Tetracycline / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013752:Tetracycline; D010400:Penicillin G
Transport von Antibiotika zum Endokard nach Applikation in die Perikardhöhle--Experimentelle Studie.