On the number of neurons in the dentate gyrus of the rat.
We have estimated the number of dentate granule cells in Sprague-Dawley and Wistar rats at 1, 4 and 12 months of age. In Sprague-Dawley rats the number of granule cells is relatively constant throughout this period at about 1 million. In Wistar rats, on the other hand, there is a progressive increase in the number from about 700,000 at 1 month to 1 million at 4 months; thereafter the number declines to about 800,000 at 1 year. Estimates of the numbers of cells in the polymorphic zone that can be stained immunohistochemically for somatostatin, cholecystokinin, vasoactive-intestinal peptide, and glutamic acid decarboxylase show no appreciable differences in the two strains.
D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry; D002452:Cell Count; D002766:Cholecystokinin / Q000032:analysis; D005260:Female; D005968:Glutamate Decarboxylase / Q000032:analysis; D006624:Hippocampus / Q000166:cytology* / Q000201:enzymology; D007124:Immunoenzyme Techniques; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009474:Neurons / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D009419:Nerve Tissue Proteins; D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D002766:Cholecystokinin; D005968:Glutamate Decarboxylase