Calcitonin gene-related peptidergic projection from the parabrachial area to the forebrain and diencephalon in the rat: an immunohistochemical analysis.
We investigated ascending fiber projections of calcitonin gene-related peptide from the parabrachial area to the forebrain and diencephalon in the rat using immunocytochemistry. Destruction of the lateral portion of the dorsal parabrachial area resulted in a marked ipsilateral decrease in the fibers containing calcitonin gene-related peptide in the ventromedial hypothalamic nucleus, indicating that cells containing calcitonin gene-related peptide in the lateral portion of the dorsal parabrachial area projected to the ipsilateral ventromedial hypothalamic nucleus. Destruction of the ventral portion of the parabrachial area resulted in a marked decrease of fibers containing calcitonin gene-related peptide in the bed nucleus of the stria terminalis, the central amygdaloid nucleus and the lateral hypothalamus just medial to the crus cerebri (the far-lateral hypothalamus), and a less marked decrease in the ventromedial thalamic nucleus. This means that there are projections from cells containing calcitonin gene-related peptide in the ventral portion of the parabrachial area to the first three regions just mentioned, and to some extent to the last.
D000344:Afferent Pathways / Q000378:metabolism / Q000502:physiology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002766:Cholecystokinin / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011149:Pons / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D013649:Taste / Q000502:physiology; D013687:Telencephalon / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D002766:Cholecystokinin; D015740:Calcitonin Gene-Related Peptide