Bilateral focal cortical atrophy and chronic ergotamine abuse.
A 67-year-old patient took 5 mg of ergotamine daily for 18 months. His headaches and dysphoria were greatly improved by stopping this drug. Brain imaging by CT and magnetic resonance techniques showed numerous atrophic lesions that may represent infarcts due to occlusion of superficial cortical vessels.
D000368:Aged; D001284:Atrophy; D001927:Brain Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply; D002544:Cerebral Infarction / Q000139:chemically induced / Q000000981:diagnostic imaging; D004878:Ergotamine; D004879:Ergotamines / Q000506:poisoning*; D004881:Ergotism / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007383:Intermittent Claudication / Q000139:chemically induced; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000000981:diagnostic imaging; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D004879:Ergotamines; D004878:Ergotamine