Coronary heart disease and risk factor modification. Is there a threshold?
Modification of coronary heart disease risk factors may play an important role in the control and alteration of the atherosclerotic process. The amount of modification necessary to obtain beneficial results is a controversial issue. Review of epidemiologic studies and recent arteriographic investigations allows for the approach to the issue of threshold levels of modification that may be required prior to obtaining some benefit. Serum lipoproteins appear to play a central role in the atherosclerotic risk factor relationship. On the basis of current evidence, clinical aims are suggested for coronary heart disease risk factor modification in order to assist in obtaining optimal health goals.
D000328:Adult; D001161:Arteriosclerosis / Q000503:physiopathology; D001794:Blood Pressure; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012306:Risk; D012907:Smoking; D014481:United States
D008055:Lipids; D002784:Cholesterol