[Radiosensitizing activity of maleic acid derivatives. Effect of maleic acid o-nitroanilide, anilide and diethyl ester on the survival of gamma-irradiated cells of Escherichia coli B/r].
Among three substances under study, only o-nitroanilide of maleic acid (oNAM) possessed a radiosensitizing activity. Radiosensitivity of E. coli B/r cells irradiated in the presence of Ar and oNAM was higher by 4.8 times than that of irradiated controls. The survival rate of E. coli B/r cells irradiated in the presence of oxygen was changed by 1.4 times by the effect of oNAM.
D000332:Aerobiosis; D000693:Anaerobiosis; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects*; D008298:Maleates / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D008298:Maleates; D011838:Radiation-Sensitizing Agents; C047560:maleic acid 2-nitroanilide; C047561:maleic acid anilide; C014476:diethyl maleate
Radiosensibiliziruiushchaia aktivnost' proizvodnykh maleinovoĭ kisloty. Vliianie o-nitroanilida, anilida i diétilovogo éfira maleinovoĭ kisloty na vyzhivaemost' gamma-obluchennykh kletok Escherichia coli B/r.