Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein.
The transforming protein of Rous sarcoma virus, p60src, was shown to be acylated at its amino terminus with the long-chain fatty acid myristic acid by isolation of a tryptic peptide with the following structure: myristylglycylserylseryllysine. The occurrence of this unusual posttranslational modification in the cyclic adenosine monophosphate-dependent protein kinase and in several transforming protein kinases of mammalian retroviruses suggests that myristylation of the amino terminal glycyl residue may be critical for the function of certain proteins related to cell transformation and growth control.
D000215:Acylation; D000595:Amino Acid Sequence; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D019814:Myristic Acid; D009227:Myristic Acids / Q000032:analysis* / Q000378:metabolism; D015688:Oncogene Protein pp60(v-src); D011494:Protein Kinases / Q000032:analysis* / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014764:Viral Proteins / Q000032:analysis* / Q000378:metabolism
D009227:Myristic Acids; D014764:Viral Proteins; D019814:Myristic Acid; D011494:Protein Kinases; D015688:Oncogene Protein pp60(v-src)