Influence of prostacyclin on early morphological changes in the rabbit brain after complete 20-min ischemia.
Complete 20-min lasting cerebral ischemia was induced in 12 rabbits. They received PGI2 3 min before, during, and for 15 min after ischemia. Control animals with complete cerebral ischemia over the same period of time were not given PGI2 medication. The ECoG changes of the animals receiving PGI2 recovered twice as fast as those of the controls. PGI2 had no noticeable effect on the loosening of the CNS white matter after ischemia; however, the perivascular swelling was much less conspicuous. PGI2 reduced the spectrum of neuronal changes and decreased the number of pathologically changed neurons in the cerebral hemispheres. Sporadically, the Purkinje cells underwent homogenisation without shrinkage of cytoplasm. The bulbar motoneurons were morphologically normal in all animals treated with PGI2. The results indicate a cytoprotective action of PGI2 on cerebral neurons during ischemia, and/or the prevention of CBF disturbances by this compound.
D000818:Animals; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004569:Electroencephalography; D011464:Epoprostenol / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits
D011464:Epoprostenol