A histological, immunological, and electron microscopic study of bovine collagen implants in the human.
The histological fate of an injectable form of type I bovine dermal collagen (Zyderm collagen implant) in the human dermis and subcutaneous tissue has been studied. Sequential biopsies were analyzed by hematoxylin-eosin and Weigert's stains, by immunofluorescence (using a highly specific rabbit anti-Zyderm collagen antibody and a specific anti-human type III collagen antibody), and by electron miscroscopy. The results of this study suggest that the bovine implant material stimulates a host response resulting in implant degradation and replacement by newly generated host collagen.
D000328:Adult; D000368:Aged; D000818:Animals; D001672:Biocompatible Materials / Q000276:immunology; D001706:Biopsy; D002417:Cattle; D003094:Collagen / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D004343:Drug Implants; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007249:Inflammation / Q000473:pathology; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron; D012867:Skin / Q000276:immunology
D001672:Biocompatible Materials; D004343:Drug Implants; D007074:Immunoglobulin G; D003094:Collagen