Mitomycin C extravasation ulcers.
In a four-year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed. The ulcers should be excised, and primary closure is recommended; if it is not possible then the defect is covered by a partial thickness skin graft.
D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000150:complications*; D006801:Humans; D007263:Infusions, Parenteral; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects*; D009336:Necrosis; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology
D008937:Mitomycins; D016685:Mitomycin