Blood transfusions generate/increase previously absent/weak blocking antibody in women with habitual abortion.
Women who suffered recurrent spontaneous abortions of unknown cause were studied for cellular reactivity and blocking antibody in a one-way mixed lymphocyte culture. A defined group of 20 women whose serum displayed no blocking capacity was given three transfusions of leukocyte-rich erythrocyte concentrates. Serum from all women displayed significant blocking capacity 2 months after the third transfusion. Because blocking antibody seems to be one of the necessary prerequisites for successful pregnancy, leukocyte transfusions from third-party donors ought to be an effective cure for habitual abortion in selected cases.
D000017:ABO Blood-Group System; D000026:Abortion, Habitual / Q000276:immunology* / Q000517:prevention & control; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis*; D008222:Lymphokines / Q000032:analysis*; D011247:Pregnancy
D000017:ABO Blood-Group System; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines