Recent advances in cardiopulmonary bypass and the clinical application of myocardial protection.
Basic scientific research has provided the impetus to develop cardioplegic solutions that offer excellent myocardial preservation. Future research will continue to develop methods for better delivery of cardioplegia to all myocardial regions. In addition, earlier detection of evolving ischemic damage during aortic cross-clamping might provide a basis for earlier intervention to reverse developing myocardial injury. At the present time, the cardiac surgeon has many cardioplegic solutions and delivery systems from which to choose. Only by understanding the principles involved in myocardial preservation will the surgeon be able to develop a system that will work best in his or her clinical practice.
D002021:Buffers; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006328:Cardiac Catheterization / Q000295:instrumentation; D002315:Cardiopulmonary Bypass / Q000379:methods / Q000639:trends*; D003326:Coronary Circulation; D004734:Energy Metabolism; D005112:Extracorporeal Circulation / Q000639:trends; D006324:Heart Arrest, Induced / Q000639:trends*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D009994:Osmolar Concentration; D010107:Oxygenators, Membrane; D010477:Perfusion; D013696:Temperature
D002021:Buffers; D002121:Calcium Channel Blockers