[A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (1) Experimental study on basic characteristics in dogs].
A new embolus consisting of a fibrin clot containing an anticancer drug (mitomycin-C) was devised. An experimental study was then performed using the new embolus in dogs and several interesting characteristics were observed. The fibrin clot containing mitomycin-C was in a fluid from when infused and its action as an embolus did not occur until it reached a target artery. The fibrin clot containing mitomycin-C formed a mold within of the arteries in which it was embolized and was soluble with urokinase during a ten-hour period. The release of mitomycin-C from the fibrin clot was sustained over sixty hours. The intraarterial occlusion formed by fibrin clot was temporary, and recanalization was observed over forty-eight by hours by both angiography and pathological examination.
D000818:Animals; D002122:Calcium Chloride / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D004285:Dogs; D004621:Embolization, Therapeutic; D005340:Fibrinogen / Q000008:administration & dosage*; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D013917:Thrombin / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D008937:Mitomycins; D016685:Mitomycin; D005340:Fibrinogen; D013917:Thrombin; D002122:Calcium Chloride