Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor.
A bio-antimutagen, isolated from Japanese green tea (leaves of Camellia sinensis), reduced high spontaneous mutations due to altered DNA-polymerase III in a mutator strain of Bacillus subtilis. Chemical studies showed that the factor was epigallo-catechin-gallate (EGCg).
D001412:Bacillus subtilis / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D009153:Mutagens / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology*; D013662:Tea / Q000032:analysis*
D001578:Benzopyrans; D009153:Mutagens; D010936:Plant Extracts; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate