[Transplantation of allogeneic bone marrow treated in vitro with Campath-1 monoclonal antibody].
5 patients underwent bone marrow transplantation for severe aplastic anemia (2) and acute leukemia (ALL) in first remission (3). Graft versus host disease prophylaxis was performed by depleting T lymphocytes in the donor bone marrow with the rat monoclonal Campath-1 and autologous complement. In addition, patients received cyclosporin A. Engraftment occurred normally in all 5 patients but 1 patient (SAA) had a late graft failure. Two patients suffered mild degrees of GvHD. All patients are currently in complete remission, one having undergone a second transplantation.
D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007945:Leukemia, Lymphoid / Q000628:therapy*; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal
Transplantation de moelle osseuse allogénique traitée in vitro par l'anticorps monoclonal Campath-1.