Isolation and purification of O6-alkylguanine-DNA alkyltransferase from human leukemic cells. Prevention of chloroethylnitrosourea-induced cross-links by purified enzyme.
D002460:Cell Line; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000201:enzymology* / Q000378:metabolism; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism; D008780:Methyltransferases / Q000302:isolation & purification* / Q000378:metabolism; D009603:Nitroso Compounds / Q000494:pharmacology*; D019853:O(6)-Methylguanine-DNA Methyltransferase
D003432:Cross-Linking Reagents; D009603:Nitroso Compounds; C041148:N-(2-chloroethyl)-N-nitrosoacetamide; D004247:DNA; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase