Changes in intramuscular collagen and fibronectin in denervation atrophy.
The distribution of collagen types I, III, and V and fibronectin was investigated by means of immunofluorescent techniques in denervated and normal rat skeletal muscle. During a period of 28 days, a distinct atrophy developed in the denervated gastrocnemius muscle and was accompanied by an increase in types I and III collagen in the endomysium and perimysium. The amount of type V collagen showed little change, whereas fibronectin increase closely parallelled types I and III collagen. The results indicate that denervation atrophy in muscles is accompanied by striking fibrotic changes due to mesenchymal types I and III collagen.
D000818:Animals; D003094:Collagen / Q000145:classification / Q000378:metabolism*; D005260:Female; D005353:Fibronectins / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism / Q000473:pathology; D009133:Muscular Atrophy / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005353:Fibronectins; D003094:Collagen