Evaluation of sperm parameters in clinical trial with clomiphene citrate of oligospermic men.
A randomized group of 101 oligospermic men, with low or normal serum follicle-stimulating hormone levels and infertile marriages of more than 2 years were studied with and without clomiphene citrate. For 6 to 9 months 56 patients were treated with 50 mg. clomiphene citrate daily and 45 men were given no treatment. Significant improvement in volume, sperm density and sperm motility was observed in the treated group but not in the control group. Sperm density greater than 20 times 10(6) per ml. was obtained in 18 men and there were 7 pregnancies in the treated group. In the control group 3 men had a sperm count greater than 20 times 10(6) per ml. and there was no pregnancy. This study showed statistically significant improvement in sperm parameters in the treated group but not in the untreated patients.
D002986:Clinical Trials as Topic; D002996:Clomiphene / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy* / Q000503:physiopathology; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects
D002996:Clomiphene; D005640:Follicle Stimulating Hormone