The topical effects of Wy-41,195 [2-cyano-3-(methylamino)phenylamino] oxoacetic acid, sodium salt and disodium cromoglycate in the rat passive eyelid anaphylaxis.
Wy-41,195 demonstrated significant inhibitory effects (54-60%) when administered topically at 0.25-2% concentrations in a rat passive eyelid anaphylaxis assay. In contrast, topically applied disodium cromoglycate (DSCG) showed non significant inhibition at these concentrations. The potency of Wy-41,195 was more than 8 times greater than DSCG, and this compound may be an effective topical agent in man in preventing allergic and associated conditions.
D000287:Administration, Topical; D000596:Amino Acids; D000818:Animals; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000276:immunology*; D005143:Eyelids; D007165:Immunosuppression Therapy; D010072:Oxamic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; C031308:(2-cyano-3-(methylamino)phenyl)oxoacetic acid; D004205:Cromolyn Sodium; D010072:Oxamic Acid