Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
The products of six unidentified reading frames of human mitochondrial DNA are precipitated from a mitochondrial lysate by antibodies against highly purified native beef heart NADH-ubiquinone oxidoreductase (complex I). These products are enriched greatly in a human submitochondrial fraction enriched in NADH-Q1 and NADH-K3Fe(CN)6 oxidoreductase activities. We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase.
D000818:Animals; D002417:Cattle; D003579:Cytochrome Reductases / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005796:Genes; D006801:Humans; D007425:Intracellular Membranes; D046911:Macromolecular Substances; D008970:Molecular Weight; D016660:NAD(P)H Dehydrogenase (Quinone); D009245:NADH Dehydrogenase / Q000235:genetics* / Q000276:immunology; D009247:NADH, NADPH Oxidoreductases / Q000235:genetics*; D011808:Quinone Reductases / Q000235:genetics*
D004272:DNA, Mitochondrial; D046911:Macromolecular Substances; D009247:NADH, NADPH Oxidoreductases; D003579:Cytochrome Reductases; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases; D009245:NADH Dehydrogenase