Corticosteroid stimulation of the growth of Plasmodium falciparum gametocytes in vitro.
Corticosteroids were found to enhance gametocyte production in vitro in two gametocyte-producing chloroquine-resistant strains of Plasmodium falciparum. No significant enhancement was observed in two chloroquine-sensitive strains. Gametocytes were not induced by corticosteroids in a fifth strain which had lost the ability to produce gametocytes.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D006854:Hydrocortisone / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D003348:Cortisone; D006854:Hydrocortisone