Idiopathic haemochromatosis and eye symptoms. A case report.
A 61-year-old man with idiopathic haemochromatosis and eye symptoms is described. The examination showed microaneurysms scattered over the bulbar conjunctiva, and some discrete pigmentations in the superficial tissue in the perilimbal area. Each cornea revealed a light brown, ellipsoid opacity with the longest diameter horizontally, seemingly being located in the corneal epithelium and/or the anterior part of the stroma. A corneal biopsy was examined by light and electron microscopy. Two different types of granules were found mainly located to the Bowman's membrane. X-ray microanalysis showed no detectable amounts of iron, but high concentrations of phosphorus and calcium, and in addition magnesium in one type of the granules. Treatment with EDTA improved the vision considerably.
D003228:Conjunctiva / Q000473:pathology*; D003315:Cornea / Q000473:pathology* / Q000648:ultrastructure; D004492:Edetic Acid / Q000627:therapeutic use; D004577:Electron Probe Microanalysis; D004848:Epithelium / Q000473:pathology; D006432:Hemochromatosis / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014786:Vision Disorders / Q000188:drug therapy / Q000209:etiology
D004492:Edetic Acid