Inhibition of phagosome-lysosome fusion in macrophages by soluble extracts of virulent Brucella abortus.
Water extracts of virulent Brucella abortus were able to inhibit phagosome-lysosome fusion in unelicited murine peritoneal macrophages following ingestion of yeast. Extracts from an avirulent strain were unable to produce a similar effect. Lipopolysaccharide from B abortus did not appear to be involved with the ability of the extracts to inhibit fusion.
D000482:Allantois; D000818:Animals; D001826:Body Fluids / Q000502:physiology; D002003:Brucella abortus / Q000472:pathogenicity*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008247:Lysosomes / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008561:Membrane Fusion / Q000187:drug effects; D051379:Mice; D010537:Peritoneum / Q000166:cytology; D010587:Phagocytosis; D012441:Saccharomyces cerevisiae / Q000502:physiology; D014774:Virulence
D008070:Lipopolysaccharides