Evidence that the anterior hypothalamus contributes to the control of tonic secretion of follicle-stimulating hormone in the female rat.
A horizontal knife cut was placed between the dorsal anterior hypothalamic area (DAHA) and the medial basal hypothalamus to examine the role of the DAHA in the selective secretion of follicle-stimulating hormone (FSH) following unilateral ovariectomy (ULO) and bilateral ovariectomy of the rat. Complete cuts markedly attenuated the increase in FSH observed 8 h after ULO, whereas incomplete or sham cuts did not. Concentration of luteinizing hormone (LH) did not increase in any group. These cuts also blocked the prolongation of estrous FSH secretion observed in long-term hemicastrated rats, since FSH levels on estrus were significantly lower in rats with complete cuts than in those rats given sham or incomplete cuts. In contrast, neural surgery had no effect on proestrous FSH concentrations. Finally, when FSH levels were monitored 2 days after bilateral ovariectomy, the postcastration rise in FSH was not altered by any neurosurgical procedures. These results support the hypothesis that a neural system originating in, or passing through, the DAHA is necessary for the selective increase in FSH following ULO.
D000818:Animals; D002369:Castration; D004971:Estrus; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000502:physiology; D009929:Organ Size; D010053:Ovary / Q000033:anatomy & histology; D011247:Pregnancy; D011359:Proestrus; D051381:Rats; D011919:Rats, Inbred Strains
D005640:Follicle Stimulating Hormone