Mononuclear and multinuclear macrophages in filarial infections.
Filarial infections commonly involve chronic tissue responses to these complex and resiliant organisms. These responses, which occur with a number of the parasitic stages of filariae, involve macrophages, and these cells appear to be important in immunologically induced destruction and removal of these important parasites of man and animals. Details of their presence and experimental induction as well as their distinction into a number of morphological types, including multinuclear (giant cell) forms, is described in this communication. The ability of these various forms to function in phagocytic and immunologically mediated adherence assays is also described.
D000818:Animals; D002009:Brugia; D002467:Cell Nucleus / Q000473:pathology; D004605:Elephantiasis, Filarial / Q000276:immunology* / Q000469:parasitology; D006801:Humans; D066298:In Vitro Techniques; D008209:Lymphedema / Q000276:immunology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D009855:Onchocerciasis / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D010587:Phagocytosis; D051381:Rats