The effect of a prostaglandin I2 analogue (OP-41483) on renal function in burned rabbits.
It is known that the number of platelets decreases after burn injury. However, the mechanism of such a decrease and its influence on systemic organs have not been fully elucidated. In this study, we evaluated the efficacy of OP-41483 (a derivative of the prostaglandin I2 (PGI2) in burned rabbits with special reference to its association with renal function. Full thickness skin loss burns, covering 35 per cent of the total body surface area, were experimentally produced on the back of rabbits. Among the following groups of rabbits (six rabbits each), the time courses of renal function and platelet function were compared; Group I (no treatment), Group II (fluid therapy only), Group III (treated with OP-41483 + fluid therapy; IIIa: 50 ng/kg/min, IIIb: 75 ng/kg/min, IIIc: 100 ng/kg/min). The results show that in Group I, all rabbits died after 8 h. Renal function tests in this group showed a decrease in creatinine clearance and increases in FENa and CH2O. Such changes were improved in Groups IIIb, IIIa and II (in order of the degree of improvement). Group IIIc showed no improvement. As for the platelets the decrease in platelets was the smallest in Group IIIb, where platelets showed no decrease until 8 h after injury and the fibrinogen concentration increased. No improvement was found in Group IIIc by our tests, presumably owing to an overdose of OP-41483. The optimal dose of OP-41483 for improving the renal function of burned rabbits was 75 ng/kg/min in our study.
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000473:pathology; D001806:Blood Urea Nitrogen; D002056:Burns / Q000097:blood* / Q000503:physiopathology; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D010979:Platelet Function Tests; D011817:Rabbits
D011464:Epoprostenol; C035847:ataprost