[Secondary immune response to flagellin conjugates with polyacrylic acid].
The conditions of the activation of immunological memory by means of flagellin and its conjugate with polyacrylic acid (PAA) have been studied. The flagellin-PAA conjugate has proved to be capable of inducing the appearance of memory cells when introduced in doses, considerably lower (0.01 and 0.001 micrograms) than those of native protein (0.1, 1 and 10 micrograms). At the same time no manifest differences in the reactivation of flagellin-induced and conjugate-induced memory cells by the antigen have been established. Immunization with protein, as well as with its conjugate, has been found to induce the formation of mainly anti-Hi : 1,2 IgG in secondary immune response.
D000180:Acrylic Resins / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001426:Bacterial Proteins / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005408:Flagellin / Q000276:immunology*; D007114:Immunization; D007156:Immunologic Memory / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D012486:Salmonella typhimurium / Q000276:immunology
D000180:Acrylic Resins; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D005408:Flagellin; C006903:carbopol 940
Vtorichnyĭ immunnyĭ otvet na kon''iugaty flagellina s poliakrilovoĭ kislotoĭ.