Effect of cyclosporin A on low-dose streptozotocin diabetes in mice.
The effect of cyclosporin A administration on diabetes development following multiple low-dose streptozotocin treatment was determined in inbred mice. When given daily at a dose of 12 or 60 mg/kg body weight the drug induced an earlier development of hyperglycemia and led to persistently higher blood glucose levels. Enhancement of diabetes by cyclosporin A was also seen when the drug was given only after termination of treatment with streptozotocin.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006943:Hyperglycemia / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D001786:Blood Glucose; D003524:Cyclosporins; D007328:Insulin