Senescent cell differentiation antigen.
A terminal differentiation antigen, the senescent cell antigen, appears on the surface of senescent and damaged cells. Appearance of this antigen initiates immunologic binding of physiologic IgG autoantibodies and removal of the cells by macrophages. The senescent cell antigen appears to be derived from band 3, the major anion transport protein of erythrocytes. Both the senescent cell antigen and band 3 have been demonstrated in the membranes of all cells examined.
D001457:Anion Exchange Protein 1, Erythrocyte / Q000276:immunology / Q000378:metabolism*; D000943:Antigens, Differentiation; D000954:Antigens, Surface / Q000276:immunology*; D002454:Cell Differentiation; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology*; D010447:Peptide Hydrolases
D001457:Anion Exchange Protein 1, Erythrocyte; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D008565:Membrane Proteins; C047076:senescent cell differentiation antigen; D010447:Peptide Hydrolases