Do quinolones really augment the antifungal effect of amphotericin B in vitro?
The minimum inhibitory concentrations (MICs) for amphotericin B and the quinolones norfloxacin and ciprofloxacin against 30 clinical isolates of Candida albicans were determined in various liquid media. Interaction studies were carried out to investigate a possible synergistic action of the quinolones on the antifungal effect of amphotericin B. No interaction between the drugs studied was observed in any of the media used.
D000666:Amphotericin B / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*; D013045:Species Specificity
D011804:Quinolines; D000666:Amphotericin B