A trial of 13-cis-retinoic acid for treatment of squamous cell carcinoma and preneoplastic lesions of the head in cats.
Ten cats with a total of 15 cancerous or precancerous lesions were examined for clinical response to and histopathologic changes after treatment with 13-cis-retinoic acid. Before treatment was started, the lesions were graded according to clinical severity and biopsied for histopathologic examination. Serum samples were prepared for determining vitamin A concentrations. For comparison, serum vitamin A concentrations in 10 clinically healthy cats were determined. 13-cis-Retinoic acid (approx 3.0 mg/kg) was given to affected cats once a day for an average of 68 days. At the completion of the therapeutic trial, additional biopsy tissues were obtained for histopathologic examination, and serum was assayed for 13-cis-retinoic acid. Of the 15 lesions examined, only 1 showed partial clinical and microscopic improvement during the therapy period. The mean serum vitamin A concentration of the affected cats was not statistically different from that of the 10 healthy cats. The results of this trial indicated that 13-cis-retinoic acid used at this dosage, daily frequency, and duration did not have therapeutic efficacy for squamous cell carcinomas or preneoplastic lesions in the cat and that the mean serum vitamin A concentration did not differ between the affected cats and clinically healthy cats.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D002986:Clinical Trials as Topic; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D015474:Isotretinoin; D011230:Precancerous Conditions / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014212:Tretinoin / Q000627:therapeutic use*; D014801:Vitamin A / Q000097:blood
D014801:Vitamin A; D014212:Tretinoin; D015474:Isotretinoin