Diclofenac versus indomethacin given as intravenous infusions: their effect on haemodynamics and bleeding time, and side-effects in healthy subjects.
Given as an intravenous infusion during a 1-hour period, 32.5 mg diclofenac and 25 mg indomethacin did not cause significant changes in blood pressure or pulse rate in 31 healthy subjects. One hour after the end of the infusion, the bleeding time was significantly prolonged with both drugs; however, the mean values were within the normal range. There was no difference in the type of side-effects recorded in this study when compared to previous reports, except for a centrally stimulating effect of diclofenac, which appeared in 11 subjects. Diclofenac and indomethacin thus seem suitable for a patient study of pre-, intra- and postoperative treatment of pain.
D000328:Adult; D001760:Bleeding Time; D001777:Blood Coagulation / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011897:Random Allocation
D004008:Diclofenac; D007213:Indomethacin