Prophylaxis for acute stress ulcers. Antacids or cimetidine.
Two hundred and forty-nine patients are divided into four homogenous groups to compare the efficacy of Cimetidine versus antacids, as well as the mode of delivery--bolus versus continuous drip--in the prophylaxis of acute hemorrhagic gastritis in critically ill patients. Antacids were favored over Cimetidine, and the continuous drip was the superior method with both drugs.
D000208:Acute Disease; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007441:Intubation, Gastrointestinal; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control / Q000601:surgery; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013312:Stress, Physiological / Q000150:complications*; D013997:Time Factors
D000863:Antacids; D002927:Cimetidine