[Toxic epidermal necrolysis (Lyell's syndrome) caused by piroxicam, with fatal outcome from disseminated aspergillosis].
A case of Lyell Syndrome provoked by ingestion of an antirheumatic drug (Piroxicam) is commented. The evolution under treatment with steroids and broad spectrum antibiotics was excellent but once recovered from this, the patient died subsequently to a systemic infectious process caused by an Aspergillosis with pulmonary involvement and secondary affectation of the kidneys, brain liver, and heart. The hepatic involvement during the acute stage is discussed and evaluated (increase of transaminases), amylasemia, amylasuria, anemia and thrombopenia which persisted throughout the process and presumably conditioned the evolution of the disease.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001228:Aspergillosis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000473:pathology; D013843:Thiazines / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D010894:Piroxicam
Necrolisis epidérmica tóxica (síndrome de Lyell) por piroxican, con evolución fatal por aspergilosis diseminada.