Serum IL-2 inhibitor in mice. I. Increase during infection.
Serum from normal mice contains an inhibitor of interleukin-2 (IL-2) which probably interacts directly with IL-2. Athymic mice and normal mice kept under specific pathogen-free conditions do not show this activity, whereas mice infected with malaria parasites have increased serum levels of inhibitor. This IL-2 inhibitor may play an important part in regulating T-cell function.
D000818:Animals; D002460:Cell Line; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000032:analysis* / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D010962:Plasmodium berghei; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007375:Interleukin-1; D007376:Interleukin-2