Indomethacin treatment in a patient with lithium-induced polyuria.
Lithium intoxication causes polyuria, central nervous system manifestations, and ultimately stupor progressing to coma. Moreover, polyuria leading to hypernatraemia itself can progress to convulsions and coma. We present a patient with lithium intoxication who remained polyuric, hypernatraemic and somnolent despite normal serum lithium concentrations. After institution of indomethacin orally, polyuria and hypernatraemia disappeared and patient regained consciousness.
D003128:Coma / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced / Q000188:drug therapy; D007213:Indomethacin / Q000627:therapeutic use*; D008094:Lithium / Q000506:poisoning*; D016651:Lithium Carbonate; D008875:Middle Aged; D011141:Polyuria / Q000139:chemically induced / Q000188:drug therapy*
D016651:Lithium Carbonate; D008094:Lithium; D007213:Indomethacin