In vitro lymphokine release by lymphocytes from mice infected with Salmonella.
Lymphocytes generated in mice by infection with Salmonella enteritidis 11RX release interleukin 2 and macrophage activation factor upon subsequent in vitro culture with bacterial antigens. Lymphokine release requires the co-culture of non-adherent sensitized Lyt 1+2- T cells and adherent metabolically active accessory cells; the interaction between these two populations is restricted by the H-2 I-A locus. Following systemic immunization with the 11RX strain, the two lymphokines are produced in parallel by peritoneal cells, whereas spleen cells primarily release macrophage activation factor.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis; D001681:Biological Assay; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2 / Q000032:analysis; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism*; D016215:Macrophage-Activating Factors; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D012480:Salmonella Infections / Q000276:immunology*
D000954:Antigens, Surface; D003524:Cyclosporins; D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D008222:Lymphokines; D016215:Macrophage-Activating Factors