Allogeneic fetal liver transplantation in acute leukemia.
Three patients with acute leukemia in first complete remission were transplanted with fetal liver cells from May 1983 to June 1984. A conditioning regimen of cyclophosphamide (60-80 mg/kg) and TBI 600-700 rads (a dose rate of 5-7r per minute) was taken. The hemopoietic and immunological recovery was rapid and complete in every patient. There was proof of chimerism in case 1 as demonstrated by the existance of the XX karyotype of donor fetus in 68.7% and 75% of marrow metaphases, in 25% of peripheral blood metaphases, by the appearance of new HLA-antigens and RBC blood type antigens of donor origin. The serum alpha-fetoprotein level increased and maintained for 40 days in case 2, but definite evidence of engraftment was not observed. The allogeneic marker, the donor's HLA-antigens and RBC isoenzyme, were detected in case 3.
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000628:therapy*; D008099:Liver / Q000196:embryology; D016031:Liver Transplantation; D008297:Male; D011247:Pregnancy; D014184:Transplantation, Homologous
D006680:HLA Antigens