Changes in immunoreactive basic somatomedin in conscious and anaesthetized male rats.
Basic somatomedin (B-SM) like insulin-like growth factor-I or somatomedin-C belongs to the basic group of somatomedins. In preliminary studies on the control system for B-SM, we have found that plasma levels of immunoreactive B-SM (IRSM) fluctuate in conscious adult male rats. The peaks average 85% of the local baseline level (minimum of 6 points) and occur with an interpeak interval of 2.1 h. In rats anaesthetized with nembutal (50 mg/kg) very few peaks were found. After approximately 3.4 hr. of anaesthesia, plasma IRSM levels dropped precipitously with a calculated T1/2 of 50 minutes. These results suggest that IRSM levels may be related to serum CH levels which occurred 4 hr previously and that part of variation seen in serum levels in conscious rodents may be due to physiological fluctuations.
D000758:Anesthesia; D000818:Animals; D002940:Circadian Rhythm; D013006:Growth Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013002:Somatomedins / Q000097:blood*; D013997:Time Factors
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D010424:Pentobarbital