Investigation of the cytotoxic effects of DNA damaging agents on neurofibromatosis cells.
Cells cultured from individuals with neurofibromatosis, a genetic syndrome associated with a predisposition to malignancy, were studied. We examined survival as measured by colony formation in skin fibroblasts from 5 patients with neurofibromatosis after exposure to X-rays, ultraviolet light and an alkylating agent. We did not observe mutagen hypersensitivity in neurofibromatosis cells as compared to normal controls.
D000293:Adolescent; D000328:Adult; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D002648:Child; D004247:DNA / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009456:Neurofibromatosis 1 / Q000235:genetics*; D014466:Ultraviolet Rays; D014965:X-Rays
D008769:Methylnitronitrosoguanidine; D004247:DNA