The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae).
The ability of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae) to affect the activities of a range of mammalian and microbial aspartic proteinases was examined. The inhibitor appeared to be completely selective in that only the aspartic proteinase A from yeast was inhibited to any significant extent. IA3 thus represents the first example of a totally specific, naturally occurring, aspartic-proteinase inhibitor.
D000818:Animals; D016282:Aspartic Acid Endopeptidases; D005656:Fungal Proteins / Q000494:pharmacology*; D005658:Fungi / Q000201:enzymology; D006801:Humans; D011480:Protease Inhibitors / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000032:analysis*; D029701:Saccharomyces cerevisiae Proteins
D005656:Fungal Proteins; C018134:PAI3 protein, S cerevisiae; D011480:Protease Inhibitors; D029701:Saccharomyces cerevisiae Proteins; D016282:Aspartic Acid Endopeptidases