[Leukocyte aggregation activity in the serum of a patient with Sweet's syndrome].
In the blood serum of a patient with Sweet's syndrome an aggregation activity of polimorphonuclear leucocytes was found in vitro. The aggregation response occurs with a latent period of one minute after the stimulation and was slow but sustained. The aggregation was totally inhibited by the hydrocortisone (500 mg./ml.). Although the polymorphonuclears of the patient aggregate normally being stimulated with C5a (ZAS), FMLP and the degranulant PMA, they remain unchanged with the patient's serum. A particular state of "leucocytic stimulation" induced by a serum agent, different from the common chemotactic factors, perhaps an immunocomplex, is postulated.
D002449:Cell Aggregation / Q000187:drug effects; D003872:Dermatitis / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology*
D006854:Hydrocortisone
Actividad agregante para los leucocitos en el suero de un paciente con síndrome de Sweet.