Mutagenic activity of acrinol in Salmonella typhimurium.
Acrinol, which is used as a disinfectant and an abortifacient in several countries, was tested for mutagenicity by the Ames test system. After incubation with a rat-liver S9 microsomal preparation, acrinol showed potent mutagenicity for Salmonella typhimurium strains TA98 and TA100, although it had no direct mutagenicity for the microorganisms.
D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology; D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D004202:Disinfectants / Q000494:pharmacology; D004975:Ethacridine / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*
D000020:Abortifacient Agents, Nonsteroidal; D000166:Acridines; D004202:Disinfectants; D004975:Ethacridine