Alteration of the cell surface acid phosphatase concomitant with the morphological transformation in Trypanosoma cruzi.
Acid phosphatase activity in Trypanosoma cruzi was found to be located on the external surface of the plasma membranes. Both specific activity and activity per cell of this bound enzyme were significantly higher in the cells of amastigote (an intracellular form) than that of trypomastigote (a bloodstream form) and epimastigote (culture form). During the transformation of epimastigotes to amastigotes in vitro the activity of surface acid phosphatase was elevated concomitant with the increase in population of amastigotes. These results were interpreted as that the elevated enzyme activity is required for the intracellular parasitization of this organism or is a consequence of the morphological transformation.
D000135:Acid Phosphatase / Q000378:metabolism*; D000222:Adaptation, Physiological; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D006367:HeLa Cells; D006801:Humans; D014349:Trypanosoma cruzi / Q000201:enzymology* / Q000254:growth & development / Q000502:physiology
D000135:Acid Phosphatase