Gonadotropin releasing hormone elicits abnormal hormone responses in schizophrenia.
We studied the non-specific responses of GH and PRL to gonadotropin releasing hormone (GnRH) in eleven male patients aged 18-30 in whom a diagnosis of acute schizophrenia was made according to Crow's criteria. GnRH administration was followed by a significant increase in plasma GH in five patients; plasma PRL increased in two patients. The two prolactin responders were also GH responders. Non-specific GH response was confirmed on repeated testing in two patients in whom GnRH stimulation was performed twice. During saline control, non-specific hormone responses were not observed. The abnormal hormone responses observed in acute schizophrenia are probably due to the disordered monoamine regulation characteristic of this condition.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin / Q000378:metabolism*; D012559:Schizophrenia / Q000503:physiopathology*
D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin; D013006:Growth Hormone