The synthesis and mutagenicity of the 3-ethyl analogues of the potent mutagens IQ, MeIQ, MeIQx and its 3,7-dimethyl isomer.
The title compounds were synthesized and tested for mutagenicity on Salmonella typhimurium TA98 in the presence of S9 mix. All test compounds showed lower activity than their respective 3-methyl analogues (IQ compounds). The replacement of the 3-methyl by an ethyl group should not alter the chemistry of these compounds; hence, their lower mutagenic activity could merely be of steric origin.
D007093:Imidazoles / Q000138:chemical synthesis* / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis* / Q000633:toxicity; D011804:Quinolines / Q000138:chemical synthesis* / Q000633:toxicity; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000633:toxicity; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D007093:Imidazoles; D009153:Mutagens; D011804:Quinolines; D011810:Quinoxalines