Evaluation of the Bolie model describing blood glucose response for the application to continuous subcutaneous insulin infusion.
In an attempt to develop an appropriate infusion program in a continuous subcutaneous insulin infusion system, a conventional pharmacodynamic model (the Bolie model) for describing the relationship between blood glucose and serum insulin levels was evaluated, using a depancreatized dog preparation. The Bolie model was found useful in estimating the basal insulin infusion rate. However, the model could not predict the serum insulin concentration-time profile required to maintain the postprandial blood glucose levels within a physiological range. It will be necessary to develop a more appropriate model for determining the prandial subcutaneous insulin infusion rates in the continuous subcutaneous insulin infusion system.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood; D004285:Dogs; D005502:Food; D007328:Insulin / Q000097:blood*; D007332:Insulin Infusion Systems; D008297:Male; D008954:Models, Biological; D010180:Pancreatectomy; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin