Bronchiolar epithelial lesions in spontaneously breathing premature newborn rabbits.
Premature rabbit neonates were stimulated to breathe for time periods varying between 5 and 150 min. The distribution of bronchiolar epithelial lesions was determined morphometrically. Animals breathing for 5-10 min had no lesions. Focal necrosis and desquamation of bronchiolar epithelium were found in 36 of 46 animals breathing for 15-150 min. These lesions were similar to those previously observed in premature rabbit neonates after a few minutes of artificial ventilation.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001980:Bronchi / Q000166:cytology* / Q000293:injuries; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure*; D006801:Humans; D007231:Infant, Newborn; D008854:Microscopy, Electron; D011175:Positive-Pressure Respiration / Q000009:adverse effects; D011817:Rabbits; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology