Malaria in the province of Takeo, Cambodia.
Malaria was studied in the province of Takeo, Cambodia. In the hyperendemic region of Kirivong district, 49 (46.0%) of 105 suspected patients were found to be infected, 98% of them with Plasmodium falciparum and 2.0% with P. vivax. The highest prevalence (85.7%) was recorded in the group of 15-20-year-old patients. A total of 296 patients were examined in the hospital of Takeo during one year (1983-1984) and 77 (26.0%) of them were positive. P. falciparum infection was found in 76.6% and P. vivax in 23.4% of cases. The highest prevalence (42.3%) was also in the age-group of 15-20 years. The "7-day test" was used in vivo in 15 patients in order to detect the sensitivity of P. falciparum to Fansidar. The asexual forms of parasites disappeared within 4 days, while the gametocytes survived in two patients until 7th and 8th day, respectively. The observations could not be terminated, since the two patients will fully left the hospital.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D002160:Cambodia; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D010966:Plasmodium vivax / Q000187:drug effects; D011739:Pyrimethamine / Q000494:pharmacology* / Q000627:therapeutic use; D011891:Rain; D012621:Seasons; D013413:Sulfadoxine / Q000494:pharmacology* / Q000627:therapeutic use; D013424:Sulfanilamides / Q000494:pharmacology*; D013997:Time Factors; D014329:Tropical Climate
D004338:Drug Combinations; D013424:Sulfanilamides; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine