[In vivo antitumor activity of hydrosoluble derivatives of 7-hydroxycholesterols].
Sodium bis-hemisuccinates of 7 beta- and 7 alpha-hydroxycholesterols are moderately water-soluble. They have been tested intraperitoneally against the murine Krebs-II carcinoma, grown as an ascitic tumour, and their action has been compared with that of usual chemotherapeutic drugs, cyclophosphamide, 5-fluoro-uracil, and methotrexate. The hydroxycholesterol derivatives show a faster and stronger activity (life prolongation), and lead to the complete disappearance of the tumour in about 1/3 of the cases, even with one single injection. Similar results have been obtained (on fewer cases) with two other experimental ascitic tumours, the S-180 sarcoma and the ZHC hepatoma. The mechanism of action is not known; it appears to be very different from that of the usual anti-cancer chemotherapeutic agents.
D000818:Animals; D000970:Antineoplastic Agents; D002287:Carcinoma, Krebs 2 / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006888:Hydroxycholesterols / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use; D051379:Mice
D000970:Antineoplastic Agents; D006888:Hydroxycholesterols; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
Activité antitumorale in vivo de dérivés hydrosolubles de 7-hydroxycholestérols.