[Effect of gamma irradiation on brain enkephalin hydrolase activity in the rat].
A study was made of the effect of different radiation doses on the brain enzymes degrading enkephalins. Enkephalin aminopeptidase activity decreased during the first 60 min following irradiation with a dose of 774 X 10(-4) C/kg and increased after a dose of 3096 X X 10(-4) C/kg; enkephalinase A exhibited opposite changes. 48 hr after irradiation, enkephalin aminopeptidase activity exceeded the normal level, and no significant changes occurred in encephaliase A activity irrespective of the radiation dose.
D000626:Aminopeptidases / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D010450:Endopeptidases / Q000528:radiation effects; D004745:Enkephalins / Q000378:metabolism*; D005720:Gamma Rays; D008297:Male; D015260:Neprilysin; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004745:Enkephalins; D010450:Endopeptidases; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme; D015260:Neprilysin
Vliianie gamma-oblucheniia na aktivnost' énkefalingidrolaz mozga krys.