[Systematic and local reactions during phlebography of the leg with special reference to postphlebographic complications. Randomized, prospective, intraindividual double-blind study of iopamidol and ioxithalamate (250 mg I/ml) using the 125I-fibrinogen test: II].
The rate of positive 125I-fibrinogen accumulations after typical ascending phlebography was significantly less (9/40 = 23%) with iopamidol compared with ioxithalamate (16/40 = 40%). The iodine content of the contrast media used in this intraindividual study (40 patients) was 250 mg/ml. With the 125I-fibrinogen uptake accepted as a method of reference, the clinically observed postphlebographic symptoms of thrombophlebitis were false positive in 1/6 and false negative in 3/4 of the cases. These incidences were registered for both contrast media. With the lowered iodine content (250 mg/ml), too, pain reactions were seen in approx. 50% during the injection of the ionic agent, but in none of the cases using the non-ionic agent. Not one of the commercial contrast media can be regarded as "ideal" at this time. Nevertheless, it can be concluded, that non-ionic contrast media with iodine content of 250 mg/ml are highly effective in preventing acute and delayed reactions. Moreover, this concentration seems to be adequate for optimal imaging in phlebography.
D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D007866:Leg / Q000098:blood supply*; D010690:Phlebography / Q000009:adverse effects*; D011446:Prospective Studies; D011897:Random Allocation
D003287:Contrast Media; D007483:Iothalamic Acid; C002587:ioxitalamic acid; D007479:Iopamidol
Systemische und lokale Reaktionen bei der Beinphlebographie unter besonderer Berücksichtigung postphlebographischer Komplikationen. Randomisierte, prospektive, intraindividuelle Doppelblindstudie mit Iopamidol und Ioxitalamat (250 mg J/ml) unter Verwendung des 125J-Fibrinogen-Testes: II. Mitteilung.