Effects of subconjunctivally injected antineoplastic agents on three models of corneal inflammation.
Three models of corneal inflammation--acute toxic keratitis, phlyctenular keratitis and corneal graft rejection--were induced in rabbits and treated with subconjunctival injections of antineoplastic agents (methotrexate, cytosine arabinoside, 5-fluorouracil and 6-mercaptopurine) and Solu-Medrol (methylprednisolone sodium succinate). The inflammations responded to the drugs to various degrees when compared with the response in control animals treated with saline. Cytosine arabinoside effected a slight decrease in the clinical features of acute toxic keratitis, methotrexate was superior in decreasing inflammation and neovascularization in phlyctenular keratitis, and Solu-Medrol appeared to be the most useful in the treatment of graft rejection. When injected repeatedly, 5-fluorouracil tended to have significant toxicity in the presence of inflammation.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003228:Conjunctiva; D016039:Corneal Transplantation; D005054:Eugenol; D006084:Graft Rejection / Q000187:drug effects; D007154:Immune System Diseases / Q000276:immunology; D007267:Injections; D007634:Keratitis / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D011183:Postoperative Complications; D011817:Rabbits
D000970:Antineoplastic Agents; D005054:Eugenol