Complete amino acid sequence of a unique protein related to the variable domain of lambda light chain from a case with Fanconi syndrome.
The complete amino acid sequence has been determined of a unique protein from a 55-years-old female with multiple myeloma associated with Fanconi syndrome. It existed in a monomer form with an apparent molecular weight of 10K daltons, and was consisted of 106 amino acid residues. The sequence was characteristic of the V-region of lambda light chains and was highly homologous with that of the first 106 residues of V lambda III subgroup. The presence of an intact light chain as well as a 13K daltons fragment, corresponding to the entire C-region, strongly suggests that the unique component is a catabolic product from the intact light chain rather than an aberrant product of synthesis.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D005198:Fanconi Syndrome / Q000150:complications / Q000652:urine*; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000652:urine*; D007146:Immunoglobulin lambda-Chains / Q000652:urine*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000652:urine*; D011507:Proteinuria / Q000209:etiology / Q000652:urine; D014357:Trypsin
D000596:Amino Acids; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D014357:Trypsin