Niridazole: Evidence for promutagenic events involving guanine-cytosine and adenine-thymine base pairs.
Niridazole, a widely used antiprotozoan agent, is mutagenic for Salmonella typhimurium strains that contain guanine-cytosine as well as adenine-thymine base pairs at their mutational sites. The mutagenic activity for both types of targets depends upon nitroreduction.
D001483:Base Sequence; D001711:Biotransformation; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009560:Niridazole / Q000494:pharmacology*; D009601:Nitroreductases; D010088:Oxidoreductases / Q000378:metabolism; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D010088:Oxidoreductases; D009601:Nitroreductases; D009560:Niridazole