An ocular reaction index for use in the study of onchocerciasis.
To evaluate ocular changes of onchocerciasis, we constructed a single ocular reaction index. Counts of microfilaria in the anterior chamber and cornea, corneal punctate opacities, and grades of limbitis and uveitis were rated from 0 to 6 and then summed. The index was applied to the ocular findings of the subjects who were entered in a study comparing diethyl-carbamazine with ivermectin and found to be valid and stable over time. It is suggested that the proposed index can be used to evaluate a patient's ocular status following treatment or during the course of disease.
D002986:Clinical Trials as Topic; D003315:Cornea / Q000469:parasitology; D004049:Diethylcarbamazine / Q000627:therapeutic use; D004311:Double-Blind Method; D005123:Eye / Q000469:parasitology / Q000473:pathology*; D006801:Humans; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use; D008297:Male; D009854:Onchocerca / Q000302:isolation & purification; D009855:Onchocerciasis / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology*
D007783:Lactones; D007559:Ivermectin; D004049:Diethylcarbamazine