Multistrain comparison of three antimicrobial prophylaxis regimens in experimental postoperative Pseudomonas endophthalmitis.
We compared subconjunctivally administered ceftazidime and BMY 28142, two third-generation cephalosporins, to a regimen of gentamicin and cefazolin for their ability to prevent experimental Pseudomonas postoperative endophthalmitis in rabbits. After extracapsular lens extraction, an inoculum of Pseudomonas was injected into the vitreous; one of the three antimicrobial regimens was then administered subconjunctivally. All 25 eyes treated with gentamicin and cefazolin become infected (P = 1). Two of 25 eyes treated with BMY 28142 became infected (P less than .001). None of the 25 eyes treated with ceftazidime became infected (P less than .001).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002437:Cefazolin / Q000627:therapeutic use; D000077723:Cefepime; D002442:Ceftazidime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005128:Eye Diseases / Q000209:etiology*; D005839:Gentamicins / Q000627:therapeutic use; D007249:Inflammation / Q000209:etiology; D011184:Postoperative Period; D011552:Pseudomonas Infections; D011817:Rabbits
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D005839:Gentamicins; D000077723:Cefepime; D002442:Ceftazidime; D002437:Cefazolin