Correlation of serum anti-basement membrane zone antibody and malignancy in bullous pemphigoid.
73 patients with bullous pemphigoid were studied to examine the association between serum anti-basement membrane zone (anti-BMZ) antibody and malignancy. Indirect immunofluorescence (IIF) was performed on the sera. 37 patients had positive IIF for anti-BMZ antibodies, ranging in titer from 1:20 to 1:10,230. On a follow-up of 7-41 months (mean 22 months), only 3 patients (8%) had malignancies (endometrium, bladder, squamous cell carcinoma of the skin). 36 patients had negative IIF for anti-BMZ antibodies. On a follow-up of 5-43 months (mean 16 months), 3 patients (8%) had malignancies (breast, colon, endometrium). No correlation between the presence or absence of anti-BMZ antibody in the serum and the development of malignant disease was observed.
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000276:immunology*; D010391:Pemphigoid, Bullous / Q000097:blood / Q000150:complications / Q000276:immunology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology*
D000906:Antibodies