Systemic and regional haemodynamic profile of captopril in conscious rabbits with bilateral cellophane perinephritis hypertension.
The radioactive microsphere technique was used to study the systemic and regional haemodynamic effects of the converting enzyme inhibitor captopril (0.1, 0.3 and 1.0 mg/kg) 10 min after intravenous administration in conscious rabbits with bilateral cellophane perinephritis hypertension, an experimental model of hypertension associated with normal plasma renin levels. Captopril lowered arterial blood pressure as a result of a dose-dependent decrease in total peripheral resistance. The fall in blood pressure was accompanied by an increase in cardiac output after the second and third dose of captopril; heart rate was not significantly altered. Captopril produced a generalized peripheral vasodilatation; the changes in vascular conductance being most pronounced in the kidneys, intestines and skin which resulted in a significant increase in blood flow to these vascular beds. The effective antihypertensive properties of captopril in this 'low plasma renin' model of hypertension and the uniform increase in vascular conductances produced by captopril, which antagonizes the generalized increase in vascular resistances that characterizes cellophane perinephritis hypertension, may indicate the involvement of an increased activity of the renin-angiotensin system, possibly in tissues, such as the vascular wall and brain, in the maintenance of the elevated blood pressure in this hypertensive form.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D002476:Cellophane; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D006977:Hypertension, Renal / Q000503:physiopathology*; D008297:Male; D008863:Microspheres; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D012083:Renin / Q000097:blood
D002476:Cellophane; D002216:Captopril; D012083:Renin