[Mutagenic activity of nitrothiazole compounds].
The mutagenic activities of different nitrothiazole derivatives were examined by the Ames-test. Such nitrothiazoles which display pronounced antibacterial properties against aerobic as well as anaerobic bacteria exert strong mutagenic activities. Thereby, both base pair substitution and frame-shift mutation occur. Reduction of the nitro-group of the nitrothiazoles by bacterial nitroreductases is a prerequisite for these mutagenic activities. In contrast, nitrothiazole derivatives which are unable to inhibit bacterial multiplication are also not mutagenic.
D055598:Chemical Phenomena; D002621:Chemistry; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009154:Mutation; D009560:Niridazole / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013844:Thiazoles / Q000494:pharmacology*
D009153:Mutagens; D013844:Thiazoles; D009560:Niridazole
Mutagene Aktivität von Nitrothiazolverbindungen.