Potentiation of photodynamic therapy with haematoporphyrin derivatives by glucocorticoids.
The effect of glucocorticoids on tumour destruction by photodynamic therapy (PDT) with haematoporphyrin derivative (HPD) and light has been examined in a transplantable mouse tumour model. Administration of glucocorticoid after irradiation enhanced the effect of PDT on both Lewis lung carcinoma and B16 melanoma. Administration of methylprednisolone acetate in depot form concurrently with HPD inhibited the response to PDT while soluble hydrocortisone sodium succinate had no effect. Correctly timed administration of glucocorticoid may have a place in treatment of human tumours by PDT with HPD. Glucocorticoid did not reduce the temporary photosensitivity of the skin induced by HPD.
D000818:Animals; D002460:Cell Line; D004347:Drug Interactions; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology*; D006414:Hematoporphyrin Photoradiation / Q000009:adverse effects / Q000379:methods*; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology; D008775:Methylprednisolone / Q000031:analogs & derivatives / Q000494:pharmacology; D000077555:Methylprednisolone Acetate; D008776:Methylprednisolone Hemisuccinate / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009364:Neoplasm Recurrence, Local; D010778:Photochemotherapy / Q000379:methods*; D010787:Photosensitivity Disorders / Q000517:prevention & control; D013997:Time Factors
D005938:Glucocorticoids; D000077555:Methylprednisolone Acetate; D008776:Methylprednisolone Hemisuccinate; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone; D008775:Methylprednisolone