[Infusion of prostaglandin E1 in resting angina resistant to conventional therapy].
Effect of 48-72 hour infusion of prostaglandin E1 (PGE1) was studied in 17 patients with angina refractory to conventional medical treatment (combination of propranolol, 160 mg/day nifedipin, 30 mg/day and nitrates) by the double blind test. PGE1 was infused to 11, placebo to 6 patients. There was no difference between PGE1 and placebo groups in the number of ischemic episodes and duration of myocardial ischemia as evidenced by Holter ECG monitoring. But in 2 patients with vasospastic angina attacks of ischemia were almost completely abolished by PGE1.
D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004562:Electrocardiography; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
D000527:Alprostadil
Infuziia prostaglandina E1 pri refrakternoĭ k obychnomu lecheniiu stenokardii pokoia.