[Proteolytic destruction of a hemorrhagic toxin from the venom of the habu (Trimeresurus flavoviridis)].
The major hemorrhagic principle (HR1B) in the venom of Habu (Trimeresurus flavoviridis), a crotalid, was found to be easily inactivated and hydrolyzed by a commercial protease (Nagarse). The ability of the hydrolysate to produce the toxin-neutralizing antibody has been shown to be comparable to or superior to those of two formol toxoids used as the controls, suggesting that inactivation of HR1B by the protease provides a new method for the preparation of Habu toxoid.
D000818:Animals; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007700:Kinetics; D008970:Molecular Weight; D013381:Subtilisins / Q000378:metabolism; D014121:Toxoids / Q000302:isolation & purification
D003435:Crotalid Venoms; D014121:Toxoids; D013381:Subtilisins
Proteolytischer Abbau eines Hämorrhagischen Toxins aus dem Schlangengift der Habu (Trimeresurus flavoviridis).