Molecular aspects of beta-lactamase inhibition and inactivation by clavulanic acid: a review.
In this short review paper the authors analyse some molecular aspects of the unusual property of clavulanic acid: beta-lactamase inactivation. After a discussion of beta-lactamase structure, two possible mechanisms of beta-lactamase inactivation are examined: chemical inactivation and physical denaturation.
D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007700:Kinetics; D013045:Species Specificity; D013211:Staphylococcus aureus / Q000201:enzymology; D065093:beta-Lactamase Inhibitors
D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; D019818:Clavulanic Acid