Lidocaine reduces intravenous diazepam pain.
We studied 41 consecutive patients receiving intravenous (IV) diazepam in the preoperative holding area to evaluate whether low-dose IV lidocaine could ameliorate pain of the diazepam injection. In a double-blind trial we found 1 cc of 1% lidocaine effective versus placebo at lowering the incidence of pain from 80% to 5% (P less than .001) and recommend its routine use as an antecedent to IV diazepam.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*
D008012:Lidocaine; D003975:Diazepam