Diffuse mesangial sclerosis--light, immunofluorescent and electronmicroscopy findings.
A 22-month-old child with familial infantile nephrotic syndrome due to diffuse mesangial sclerosis is presented. The case history of this patient is exceptional because of evidence of an immunologic pathogenesis of the renal disease, documented by characteristic immunofluorescent and electron-microscopy findings.
D003176:Complement C3 / Q000032:analysis; D003241:Consanguinity; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000473:pathology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000235:genetics / Q000276:immunology / Q000473:pathology*
D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G