Chemical carcinogens and proto-oncogens activation.
The induction of proto-oncogens H-ras-1 by nitrosomethylurea (Sukumar et al. (1983), 306, 658-661) is discussed in term of lack of DNA-repair of lesions induced in DNA by this alkylating agent, particularly O6-methylguanine residues and apurinic/apyrimidinic sites.
D000477:Alkylating Agents / Q000494:pharmacology; D000478:Alkylation; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D005786:Gene Expression Regulation / Q000187:drug effects; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008745:Methylation; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes / Q000187:drug effects*
D000477:Alkylating Agents; D002273:Carcinogens; D006147:Guanine; D004247:DNA; C008449:O-(6)-methylguanine