Mechanical response of rabbit myocardium and coronary arteries to leukotriene D4. Failure to demonstrate a role in the pathophysiology of hypoxia.
We have studied the effect of leukotriene D4 (LTD4) on rabbit and rat myocardial contractility and on rabbit coronary arteries. A concentration of 2 X 10(-7) M caused only a small reduction of myocardial contractility, but caused a contraction of smooth muscle in coronary arteries similar to that obtained with potassium (30 mmoles/liter). LTD4 (2 X 10(-7) M) added to the perfusate 10 min before or at the time of reoxygenation after a period of 30 min of hypoxia did not alter contractility or resting tension. LTD4 is unlikely to be a contributing factor in the initiation of cell necrosis on reoxygenation of hypoxic myocardium.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D002396:Catechols / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006346:Heart Septum / Q000187:drug effects; D016859:Lipoxygenase Inhibitors; D008297:Male; D009637:Masoprocol; D009200:Myocardial Contraction / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D011720:Pyrazoles / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000494:pharmacology*
D002396:Catechols; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; D013189:SRS-A; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D009637:Masoprocol