[Current data on the physiological effects of aldosterone in the kidney].
In this brief review, only the physiological effects of aldosterone on electrolyte transports along the nephron will be considered. An increase in sodium reabsorption is the only effect unanimously reported. A rise in potassium excretion is probable but still under discussion. This is also the case for acid excretion, but, in this case, the mechanism is controversial. Calcium, magnesium and phosphate excretion seem to be unaffected by aldosterone. Effects on water excretion are uncertain. The cortical collecting tubule is the only segment where an aldosterone effect is ensured. In spite of some contradictory data, it seems very probable that distal tubule is also a target site for aldosterone. In contrast, numerous evidences argue against a direct effect of aldosterone along the proximal tubule and Henle's loop. Data concerning medullary collecting ducts are still controversial. In order to interpret correctly data on aldosterone action, it is absolutely necessary to keep in mind the dose of aldosterone utilized (often too high, responsible for unspecific effects), and possible dissociations between results from in vitro and in vivo experiments, or between data obtained from whole kidney and from defined tubular segments.
D000143:Acids / Q000652:urine; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001834:Body Water / Q000378:metabolism; D002118:Calcium / Q000652:urine; D004285:Dogs; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D007685:Kidney Tubules, Collecting / Q000187:drug effects; D007686:Kidney Tubules, Distal / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000187:drug effects; D008138:Loop of Henle / Q000187:drug effects; D008274:Magnesium / Q000652:urine; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D011817:Rabbits; D051381:Rats; D012964:Sodium / Q000652:urine
D000143:Acids; D010710:Phosphates; D000450:Aldosterone; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium
Données actuelles sur les effets physiologiques de l'aldostérone dans le rein.