Gene for the human T cell differentiation antigen Leu-2/T8 is closely linked to the kappa light chain locus on chromosome 2.
We have mapped the gene encoding the T cell differentiation antigen Leu-2/T8 to human chromosome 2 by hybridization of a Leu-2/T8 complementary DNA clone to DNA from a panel of mouse-human cell hybrids. In situ hybridization further localizes the gene to the 2p1 region in close proximity to the Ig kappa light chain gene. The Leu-2/T8 gene translocates with C kappa to chromosome 8 in a Burkitt lymphoma line carrying a t(2;8) translocation. These data support the hypothesis that Leu-2/T8 is the human homologue of the mouse Lyt-2,3 antigen.
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000235:genetics*; D002900:Chromosomes, Human, 1-3; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005802:Genes, MHC Class II; D005815:Genetic Code; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008297:Male; D008677:Metaphase; D051379:Mice
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D004247:DNA