In vitro monitoring of immunotherapy with serial measurement of serum levels of allergen-specific IgG antibodies.
The essence of the scientific method is in reproducibility. The use of biochemical information as the basis of clinical management decisions is as desirable in the clinical practice of allergy as it has been in other disciplines of medicine. The objective in successful immunotherapy for an IgE-mediated disorder is to elicit the maximal specific IgG response against a given antigen system. To date, the most reproducible and practical method of doing this is by measurement of serum levels of allergen-specific IgG antibodies. In this article, an attempt has been made to provide guidelines for the use of IP-specific G assay for in vitro monitoring of the effects of immunotherapy.
D000485:Allergens / Q000008:administration & dosage / Q000276:immunology*; D000918:Antibody Specificity; D003888:Desensitization, Immunologic; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis* / Q000096:biosynthesis; D008991:Monitoring, Physiologic; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D013997:Time Factors
D000485:Allergens; D007074:Immunoglobulin G