Auxiliary transplantation of part of the liver improves survival and provides metabolic support in pigs with acute liver failure.
In pigs subtotal ischemic liver cell necrosis was induced 4 days after auxiliary transplantation of 60% of the liver of an MLC-compatible donor (ATPL group, n = 13). In control animals (n = 14) temporary liver ischemia was preceded by division of the hepatic ligaments and creation of an end-to-side portacaval shunt. In the ATPL group six animals died of gastric hemorrhage, intestinal strangulation, or sepsis. The remaining seven animals survived in excellent condition until sacrifice 26 days after the induction of liver ischemia. Excellent graft function was demonstrated by uptake and excretion of 99mTc-HIDA at cholescintigraphy, ammonia detoxification, synthesis of clotting factors and glucohomeostasis. EEG recordings in the animals that underwent transplantation did not change from preischemic levels. Evidence of hepatic regeneration was found in the transplanted livers but could not be demonstrated in the damaged host livers. The control animals died in coma within 72 hours. These results indicate that auxiliary transplantation of a partial liver provides metabolic support and improves survival in animals with induced acute liver failure.
D000208:Acute Disease; D000818:Animals; D002828:Choristoma; D004569:Electroencephalography; D005260:Female; D006085:Graft Survival; D006501:Hepatic Encephalopathy / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000378:metabolism* / Q000401:mortality / Q000601:surgery; D016031:Liver Transplantation; D013552:Swine; D013997:Time Factors