[Effect of experimental alcoholic intoxication on the cell-mediated immune response in mice].
Repeated ip injection of ethyl alcohol in a relatively high dose depressed the immune response, to a greater degree in Swiss mice than in C57BL/6 mice, as shown by a diminution in granuloma size and in the hypersensitivity reaction to tuberculin compared with untreated controls. The control of bacillary multiplication in the popliteal lymph node was more efficient in alcohol-treated Swiss mice than in the corresponding controls, but was less efficient in alcohol-treated C57BL/6 animals than in their controls. Alcohol treatment caused no reduction in the number of circulating lymphocytes, and no modification of the distribution of B and T lymphocytes in the spleen, or of the stimulation of T lymphocytes in the presence of mitogens.
D000437:Alcoholism / Q000276:immunology*; D000818:Animals; D005260:Female; D006099:Granuloma / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology; D014374:Tuberculin Test
Effet de l'intoxication expérimentale par l'alcool sur la réponse d'immunite à médiation cellulaire de la souris.