[Pharmacokinetics of amoxicillin trihydrate in sheep infected experimentally with Corynebacterium pyogenes and Escherichia coli].
A comparative experiment was carried out with sheep that were infected i/v and via the joints with Corynebacterium pyogenes and Escherichia coli, and with normal sheep left as controls. The pharmacokinetic parameters were determined of amoxicillin-trihydrate following its i/m application to all animals in a 20 percent oil suspension. It was found that there was delayed excretion of the antibiotic, and as a rule it was maintained in higher concentrations in the diseased animals. the differences were likely to be due to changes in the metabolic processes and to injury of the kidneys.
D000658:Amoxicillin / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D003354:Corynebacterium Infections / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D003355:Corynebacterium pyogenes; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D007700:Kinetics; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000378:metabolism*; D013535:Suspensions; D013997:Time Factors
D013535:Suspensions; D000658:Amoxicillin
Farmakokinetika na amoksitsilin-trikhidrat pri ovtse, zarazeni eksperimentalno s Corynebacterium pyogenes i Escherichia coli.