Inhibitory effects of tannic acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase.
Soybean lipoxygenase and cyclooxygenase from ram seminal vesicles were inhibited by tannic acid and the apparent ID50's were 7.5 x 10(-7) M and 6 x 10(-6) M, respectively. The inhibition of lipoxygenase by tannic acid was noncompetitive. Benzophenone inhibited cyclooxygenase, and the ID50 was 8 x 10(-7) M. The inhibition constant, Ki values of both tannic acid and benzophenone are presented.
D000818:Animals; D001577:Benzophenones / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D007700:Kinetics; D016859:Lipoxygenase Inhibitors; D008297:Male; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology; D013025:Glycine max / Q000201:enzymology; D013634:Tannins / Q000494:pharmacology*
D001577:Benzophenones; D016861:Cyclooxygenase Inhibitors; D047348:Hydrolyzable Tannins; D016859:Lipoxygenase Inhibitors; D013634:Tannins