Cyclosporine measurement in transplantation.
Use of cyclosporine is a major breakthrough in immunosuppressive therapy for organ transplantation. Critical to its success, however, is the availability of regular and frequent measurements of the blood levels of the drug. Radioimmunoassay and/or high-pressure liquid chromatography may be employed for this analysis. Radioimmunoassay measures the parent molecule together with its metabolites, whereas high-pressure liquid chromatography measures only the parent drug, which indicates that clinical and laboratory experience, as well as an understanding of methodology, are necessary for the interpretation of cyclosporine levels.
D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008991:Monitoring, Physiologic; D011863:Radioimmunoassay
D003524:Cyclosporins