Effects of san-huang-hsieh-hsin-tang on sympathetic activity, plasma renin, and plasma aldosterone.
San-Huang-Hsieh-Hsin-Tang, an ancient Chinese remedy for gastrointestinal disorders, was also found to lower blood pressure. The authors therefore investigated the effects of this substance on sympathetic activity, plasma renin, and plasma aldosterone. Sympathetic activity and plasma renin activity, but not plasma aldosterone levels, were significantly reduced with treatment. The depressed plasma renin activity could be secondary to depressed sympathetic activity. The discrepancy between plasma renin activity and plasma aldosterone levels, which is also found with beta-blockers, could be explained by the following sequence: decreased renin----decreased aldosterone----increased serum potassium----recovery of aldosterone.
D000450:Aldosterone / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000628:therapy; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D010946:Plants, Medicinal; D012083:Renin / Q000097:blood*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000450:Aldosterone; D012083:Renin