Mouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds.
Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.
D000818:Animals; D003622:Dapsone / Q000494:pharmacology / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005528:Foot / Q000382:microbiology; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology; D007918:Leprosy / Q000178:diet therapy / Q000188:drug therapy; D051379:Mice; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D007917:Leprostatic Agents; D012701:Serotonin; C018901:desoxyfructo-serotonin; D003622:Dapsone