Glycogen synthase in prenatal rat liver.
Glycogen synthase first appears in significant levels in fetal rat liver on day 18 of gestation (22 day term), but in a mostly inactive, phospho- form. This was reflected in a decreased affinity for its allosteric activator (increased A0.5 for glucose-6-phosphate), and with limited glycogen synthesis and accumulation. Peak glycogen synthesis occurs on day 21 of gestation, and glycogen synthase is in a more dephospho-form with decreased A0.5 for G6P and increased -G6P/+G6P activity ratio. The data suggest that a significant change in phosphorylation state of synthase occurs in late gestation to facilitate the large increase in glycogen synthesis and accumulation.
D000818:Animals; D005260:Female; D005333:Fetus / Q000201:enzymology; D005865:Gestational Age; D006006:Glycogen Synthase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000196:embryology* / Q000201:enzymology; D008112:Liver Glycogen / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
D008112:Liver Glycogen; D006006:Glycogen Synthase