Sulindac hepatotoxicity: a case report and review.
A 44 year old female, previously on propranolol, phenytoin and phenobarbital, developed hepatotoxicity while on sulindac and acetaminophen containing analgesic. A limited review of hepatotoxicity and drug interactions of sulindac is presented. The possible mechanism of hepatotoxicity and its treatment is suggested.
D000082:Acetaminophen / Q000633:toxicity; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity; D005260:Female; D006801:Humans; D007192:Indenes / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000633:toxicity; D010672:Phenytoin / Q000633:toxicity; D011422:Propionates / Q000633:toxicity; D013467:Sulindac / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity*
D007192:Indenes; D011422:Propionates; C011677:benoxaprofen; D013467:Sulindac; D000082:Acetaminophen; D000431:Ethanol; D010672:Phenytoin; D010634:Phenobarbital