Gossypol and hypokalaemia.
One major side effect of administration of gossypol as a male fertility regulating agent is the occurrence of hypokalaemic paralysis. We have reviewed the common causes of hypokalaemia in clinical practice and previous studies of gossypol-induced hypokalaemia in animals and man. The available evidences suggest that gossypol induced renal leakage of potassium. The most likely mechanism is a direct toxic effect of gossypol on the renal tubules.
D000818:Animals; D001464:Barium / Q000506:poisoning; D006072:Gossypol / Q000009:adverse effects*; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications; D006980:Hyperthyroidism / Q000150:complications; D007008:Hypokalemia / Q000139:chemically induced* / Q000150:complications; D008297:Male; D009132:Muscles / Q000378:metabolism; D010243:Paralysis / Q000209:etiology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000032:analysis
D001464:Barium; D012964:Sodium; D006072:Gossypol; D011188:Potassium