Efficacy of phenytoin, procainamide, and tocainide in murine genetic myotonia.
A newly described single locus mutation in the mouse, myotonia (mto), features classical myotonia with autosomal recessive inheritance. Phenytoin, procainamide, and tocainide (drugs considered effective in the human myotonias) produced dose-dependent improvement in the behavioral myotonia of mto homozygotes.
D000818:Animals; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D008817:Mice, Mutant Strains; D009222:Myotonia / Q000188:drug therapy*; D010672:Phenytoin / Q000627:therapeutic use*; D011342:Procainamide / Q000627:therapeutic use*; D016677:Tocainide
D016677:Tocainide; D010672:Phenytoin; D008012:Lidocaine; D011342:Procainamide