[Anti-inflammatory effect of tiaprofenic acid following ocular surgery].
We evaluated the anti-inflammatory and analgesic action of tiaprofenic acid in the post-operative course of ocular surgery by means of a double-blind study versus placebo in a series of 85 patients. 41 of these patients received tiaprofenic acid and 44 received the placebo. Tiaprofenic acid was administrated at a dose of 600 mg/day according to a peri-operative therapeutic plan (2 days before and 6 days after the operation). The results demonstrate that the anti-inflammatory action of tiaprofenic acid is significantly better than that of the placebo and that it is very rapid, appearing on the day after the operation. The tolerance was very good and identical in the two groups. The use of tiaprofenic acid in ocular surgery results in a significant reduction in the intensity and the duration of the inflammatory reaction.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002387:Cataract Extraction / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003229:Conjunctival Diseases / Q000188:drug therapy; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy; D005141:Eyelid Diseases / Q000188:drug therapy; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D013508:Ophthalmologic Surgical Procedures; D010149:Postoperative Pain / Q000188:drug therapy*; D011183:Postoperative Complications / Q000188:drug therapy; D011422:Propionates / Q000627:therapeutic use*; D012163:Retinal Detachment / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid
Action anti-inflammatoire de l'acide tiaprofénique dans les suites de la chirurgie oculaire.