Escherichia coli bacteremia, meningitis, and hemochromatosis.
A 67-year-old man with Escherichia coli bacteremia and meningitis was found to have hemochromatosis. To my knowledge this is the first documented case of E coli meningitis occurring in the setting of hemochromatosis. The case raises issues regarding the role of chronic liver disease in the pathogenesis of gram-negative sepsis and the impact of iron loading on host immunocompetence and bacterial virulence.
D000368:Aged; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000382:microbiology*; D006432:Hemochromatosis / Q000150:complications*; D006801:Humans; D008297:Male; D008581:Meningitis / Q000209:etiology*; D018805:Sepsis / Q000209:etiology*; D014774:Virulence