Factors affecting the metabolic control of cytosolic and lysosomal glycogen levels in the liver.
Rats with a gentic deficiency of phosphorylase kinase have been treated with the 1,4-alpha-glucosidase inhibitor, Acarbose. Lysosomal glycogen metabolism has been markedly altered and the results support the concept of a feedback control mechanism operating on the uptake mechanism into the lysosomal compartment.
D020909:Acarbose; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D010764:Phosphorylase Kinase / Q000172:deficiency; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000494:pharmacology
D065089:Glycoside Hydrolase Inhibitors; D008112:Liver Glycogen; D014312:Trisaccharides; D010764:Phosphorylase Kinase; D020909:Acarbose