[Metabolism of antipyrine in man].
Antipyrine is widely used as a model compound to assess the hepatic metabolism in man. This drug is extensively metabolized by the hepatic microsomal drug-oxidizing system, into three main metabolites and six minor compounds of the phase I. The metabolite fate of this drug is not fully understood. A new metabolite pathway including a ring opening seems possible.
D000983:Antipyrine / Q000378:metabolism* / Q000652:urine; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006900:Hydroxylation; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism
D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; C023111:epoxidase; D010089:Oxidoreductases, N-Demethylating; D000983:Antipyrine
Métabolisme de l'antipyrine chez l'homme.