[Assessment of the effectiveness of the action of chemical compounds on the enzymatic peroxidation of lipids].
Inhibitory effects of 3-hydroxypyridines and of some drugs on NADPH-dependent lipid peroxidation was studied in liver microsomes of rats using a spectrophotometric technique with continuous monitoring of accumulation of peroxidation products. At the same time, inhibition of fatty acyl peroxidation catalyzed by the NADPH-dependent system and lipoxygenase from soybean was studied. The data obtained suggest that peroxidation, catalyzed by enzymes of two different types, may be inhibited to different degree by the same chemical compounds.
D000818:Animals; D002384:Catalysis; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008084:Lipoxygenase / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D010743:Phospholipids; D009249:NADP; D008084:Lipoxygenase
Otsenka éffektivnosti deístviia khimicheskikh soedineniĭ na fermentativnoe perekisnoe okislenie lipidov.