Characterization of an epibody. An antiidiotype that reacts with both the idiotype of rheumatoid factors (RF) and the antigen recognized by RF.
Recently, an antiidiotype to human monoclonal IgM anti-IgG autoantibodies (rheumatoid factors) was found to react also with human IgG. This peculiar antiidiotype was called an 'epibody'. We describe the induction of a similar epibody by immunization with a synthetic peptide (corresponding to one hypervariable region of the IgM-RF Glo). The results confirm the existence of epibodies, and provide the possible molecular basis of the epibody phenomenon.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D002846:Chromatography, Affinity; D007074:Immunoglobulin G / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007147:Immunoglobulin Light Chains / Q000276:immunology; D010455:Peptides / Q000276:immunology / Q000494:pharmacology; D011817:Rabbits; D012217:Rheumatoid Factor / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000941:Antigens; D001324:Autoantigens; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D010455:Peptides; C030352:rheumatoid arthritis nuclear antigen; D012217:Rheumatoid Factor