[Genetic and biochemical study of yeast acid phosphatases. XI. Gene ACP80 controls inorganic phosphate transport].
Mutations in the gene ACP80 which simultaneously lead to constitutive synthesis of repressible acid phosphatases, resistance to 1 X 10(-3) M sodium arsenate and to the disturbance of phosphate uptake in the cell were obtained. Mutations suppressible by ochre suppressors in this gene were identified. The conclusion that the gene ACP80 encodes a protein which participates in the phosphate transport into the cell, was drawn. A selective method for isolation of mutations in this gene is proposed.
D000135:Acid Phosphatase / Q000096:biosynthesis / Q000235:genetics*; D001149:Arsenates / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D005796:Genes; D005800:Genes, Fungal / Q000187:drug effects; D005809:Genes, Regulator / Q000187:drug effects; D009154:Mutation; D010710:Phosphates / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*
D001149:Arsenates; D010710:Phosphates; C009277:sodium arsenate; D000135:Acid Phosphatase
Genetiko-biokhimicheskoe izuchenie kislykh fosfataz drozhzheĭ. Soobshchenie XI. Gen ACP80 kontroliruet transport neorganicheskogo fosfata.