Congenital diaphragmatic hernia.
Congenital diaphragmatic hernia continues to be a critical problem in neonatal surgery. Despite the apparent simplicity of the anatomic defect, the physiology is complex, and survival remains uncertain. Surgical success has been achieved, but we recognize that the barrier to survival is pulmonary parenchymal and vascular hypoplasia as well as the complex syndrome of persistent fetal circulation. In many ways the problem of diaphragmatic hernia is as much of an enigma to today's physician-scientist as it was to Bochdalek in the nineteenth century. The treatment of respiratory distress after repair of congenital diaphragmatic hernia has brought out the most creative and innovative efforts of pediatric surgeons in both the laboratory and the intensive care unit.
D000818:Animals; D002315:Cardiopulmonary Bypass; D003964:Diaphragm / Q000033:anatomy & histology; D005260:Female; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000196:embryology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D007441:Intubation, Gastrointestinal; D008168:Lung / Q000002:abnormalities; D008722:Methods; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011300:Preoperative Care; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents