[Metabolic effects of ring-substituted arylalkylguanidines on insulin-sensitive systems. I. Amino-substituted benzylguanidines].
The synthesis of benzylguanidines carrying amino groups and their influence on insulin-sensitive metabolic systems are described. All substances show hypoglycemic activity in mice with intact metabolism. (3-Acetamido-benzyl)guanidine is most effective; the blood glucose concentration is lowered by 55%, accompanied by only a weak increase in serum lactate concentration; the glucose oxidation of epididymal fat cells of the rat remains unaffected.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism; D006146:Guanidines / Q000138:chemical synthesis / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction
D001786:Blood Glucose; D006146:Guanidines; D007004:Hypoglycemic Agents; D007328:Insulin; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid
Stoffwechseleffekte ringsubstituierter Arylalkylguanidine an insulinempfindlichen Systemen. I. Aminosubstituierte Benzylguanidine.