Drugs as research tools in psychology: cholinergic drugs and aggression.
A review of studies using cholinergic drugs as tools to investigate the neural mechanisms mediating affective and predatory aggressive behaviour reveals that the same two cholinergic systems are involved with both sorts of behaviour. There is a brain muscarinic system initiating aggression and a nicotinic system which inhibits aggressive behaviour. This evidence suggests that there could be two possible forms of cholinergic therapy for aggression, cholinolytics and nicotinic agonists. These possibilities are discussed.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002217:Carbachol / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology; D011235:Predatory Behavior / Q000187:drug effects; D012934:Social Isolation
D002800:Cholinesterase Inhibitors; D005731:Ganglionic Stimulants; D010277:Parasympathomimetics; D002217:Carbachol; D010830:Physostigmine