[Suppression of the parasitemia in rodent filariasis (Litomosoides carinii) by immunization with BCG and microfilaria. II. Intravenous BCG application].
By intravenous (i.v.) inoculation of living tuberculosis bacteria (BCG) non-specific resistance to microfilariae of Litomosoides carinii (Filarioidea) is induced in cotton rats. This is only possible using the preparation "Immune-BCG Pasteur F" (suspended germs), but not with "Vaccin-BCG pour scarifications" (lyophilized tuberculosis bacteria). After inoculation of Immune-BCG, followed by a challenge infection by 60 infective larvae 6 weeks later, a patent infection develops. However, the level of microfilaraemia is constantly lower than in the control. After challenge infection 12 weeks later, this effect has disappeared. Immune-BCG has no influence on the worm load or the output of microfilariae by the adult worms. If i.v. inoculation of Immune-BCG is combined with a subcutaneous injection of specific antigen--living embryos from the uteri of adult worms--the BCG-activated immune system undergoes specific sensitization. Upon challenge infection 6 weeks later, the microfilaraemia is completely suppressed, but the worm load and production of microfilariae by the adult female worms are normal. If Immune-BCG is injected i.v. 3 days before intraperitoneal injection of freeze-killed microfilariae, there is still constantly reduced microfilaraemia when challenge infection follows 12 weeks later. Obviously, the effect of this relatively weak antigen may be increased by BCG stimulation.
D000818:Animals; D000947:Antigens, Helminth / Q000008:administration & dosage / Q000276:immunology; D003411:Arvicolinae; D001500:BCG Vaccine / Q000008:administration & dosage*; D005368:Filariasis / Q000097:blood / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D005370:Filarioidea / Q000276:immunology*; D007114:Immunization; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008842:Microfilariae / Q000276:immunology; D009163:Mycobacterium bovis / Q000276:immunology*; D012376:Rodent Diseases / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D013997:Time Factors
D000947:Antigens, Helminth; D001500:BCG Vaccine
Unterdrückung der Parasitämie bei der Nagetierfilariose (Litomosoides carinii) durch Immunisierung mit BCG und Mikrofilarien. II. Intravenöse Applikation von BCG.