[Effect of tamoxifen and estrogens on breast cancer cell lines: MCF-7 and R-27, and on the uterus and vagina of fetal and newborn guinea-pigs].
The action of tamoxifen was studied in two models: in breast cancer cell lines MCF-7 and R-27. The latter is resistant to tamoxifen; 2) in the uterus and vagina of guinea pig during the perinatal period. In the breast cancer cell line MCF-7 tamoxifen blocks the proliferation of the cells and in the R-27 it does not antagonize the effects provoked by estrogens. However, in this cell line tamoxifen provokes a significant alteration of the ultrastructures. In the uterus and vagina of guinea pig (fetal and newborn) tamoxifen acts as a real estrogen and it does not block the effects provoked by estrogens.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001943:Breast Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D002460:Cell Line; D004958:Estradiol / Q000494:pharmacology; D004964:Estriol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000378:metabolism; D013629:Tamoxifen / Q000378:metabolism / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects* / Q000196:embryology; D014621:Vagina / Q000187:drug effects* / Q000196:embryology
D004967:Estrogens; D011980:Receptors, Progesterone; D013629:Tamoxifen; D004958:Estradiol; D004964:Estriol
Effet du tamoxifène et des oestrogènes dans les lignées cellulaires du cancer mammaire: MCF-7 et R-27, ainsi que dans l'utérus et le vagin du foetus et du nouveau-né de cobaye.