Adjuvant therapy for breast cancer with positive axillary nodes designed according to estrogen receptor status.
This is a preliminary report of the Southwest Oncology Group--Adjuvant Therapy in Operative Breast Cancer with Positive Axillary Nodes--in which therapy is randomized by estrogen receptor (ER) data. ER--patients receive either 1 or 2 years of CMFVP. The ER + group receive CMFVP for 1 year and/or hormonal therapy. ER + patients have a significant longer disease-free interval compared to ER--patients (P = 0.004). There was no significant difference in disease-free interval for ER--patients who receive either 1 or 2 years of CMFVP. The data for ER + patients is too preliminary to report for disease-free or total survival. Toxicity is acceptable because of frequent monitoring and examinations which results in the low percentage of life-threatening toxicity.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008408:Mastectomy; D008727:Methotrexate / Q000627:therapeutic use; D010052:Ovariectomy; D011241:Prednisone / Q000627:therapeutic use; D011897:Random Allocation; D011960:Receptors, Estrogen / Q000032:analysis*; D013629:Tamoxifen / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D011960:Receptors, Estrogen; D013629:Tamoxifen; D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D011241:Prednisone; D008727:Methotrexate