[Pharmacology of ethacizin].
Study of the relationship between the chemical structure and pharmacological action in the series of dialkylaminoacyl derivatives of phenothiazines made it possible to discover etacyzine (a diethylamine analog of etmozine). Comparison of the pharmacological action of etacyzine with that of etmozine demonstrated that the replacement of the morpholine radical of the side chain of the phenothiazine ring by the diethylamine one leads to the potentiation and increase of the duration of the antiarrhythmic effect, emergence of anti-fibrillary activity, antiischemic properties and to the ability to restrict the size of experimental myocardial infarction.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D016293:Moricizine / Q000031:analogs & derivatives; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000517:prevention & control; D010640:Phenothiazines / Q000627:therapeutic use*; D051381:Rats
D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
K farmakologii etatsizina.