A case of postpartum hemolytic uremic syndrome with severe elevations of liver enzymes.
An unusual case of multifocused postpartum thrombotic microangiopathy was encountered in a woman with pregnancy-induced hypertension, which presented clinical features different from those generally seen in postpartum hemolytic uremic syndrome or thrombotic thrombocytopenic purpura. These changes included acute disseminated intravascular coagulation, severe elevations of liver enzymes, severe renal dysfunction, and hemolytic anemia. The patient was treated successfully with heparin, gabexate mesilate, furosemide, fresh whole blood, and large doses of corticosteroid with antibiotics, and she recovered completely without sequelae. The hypothetical pathogenesis of the complex symptoms of this catastrophic clinical condition is proposed.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000201:enzymology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use; D006463:Hemolytic-Uremic Syndrome / Q000188:drug therapy / Q000201:enzymology* / Q000276:immunology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D008099:Liver / Q000201:enzymology* / Q000473:pathology; D049590:Postpartum Period; D011247:Pregnancy; D013921:Thrombocytopenia / Q000201:enzymology
D006146:Guanidines; D016670:Gabexate; D005665:Furosemide; D006493:Heparin; D000469:Alkaline Phosphatase