[Hydrogen ion concentration in tumor issue and artificial hyperglycemia].
A series of articles concerned with determination of pH in the tumour and with studies of pH changes under induced hyperglycemia are reviewed. Based on the available data the following conclusions are drawn: pH in the tumour tissue is lower than in the initial normal or surrounding tissues by 0.5 units on the average; the optimal pH value is more acidic; alkalosis in the tumour-bearing organism is a hypercompensatory reaction of the host as a result of advanced tumour in which pH is dropped; the induced hyperglycemia promotes a pronounced decrease of pH in the tumour, pH of the normal tissues being unchanged; the possibility to decrease pH in the tumour should be taken into account when developing new methods of the antitumour therapy.
D000818:Animals; D005260:Female; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D006019:Glycolysis; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D006943:Hyperglycemia / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000628:therapy; D010084:Oxidation-Reduction; D051381:Rats; D013997:Time Factors
D007527:Isoenzymes; D007773:Lactates; D006859:Hydrogen; D005947:Glucose
Kontsentratsiia ionov vodoroda v opukholevoĭ tkani i iskusstvennaia giperglikemiia.