Inactivation of interferon by serum and synovial fluids.
The stability of interferons-alpha, -beta, and -gamma (IFN) in serum and synovial fluids were compared. Interferon-beta was the least stable interferon species, losing at least 75% of its activity during incubation in samples of both serum and synovial fluid. Interferon-alpha was the most stable IFN, but interferon-gamma under these conditions approached the stability of the alpha species. The inactivation of IFN-beta was found due to dialyzable factors and hence not classical antibodies.
D001172:Arthritis, Rheumatoid / Q000378:metabolism; D004355:Drug Stability; D006801:Humans; D007370:Interferon Type I / Q000032:analysis / Q000097:blood*; D007371:Interferon-gamma / Q000032:analysis / Q000097:blood*; D007592:Joint Diseases / Q000097:blood / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000378:metabolism; D013582:Synovial Fluid / Q000032:analysis*
D007370:Interferon Type I; D007371:Interferon-gamma