Influence of aminoglycoside usage on susceptibilities.
Units of aminoglycosides issued from the hospital pharmacy and susceptibilities for Serratia marcescens and Pseudomonas aeruginosa were retrospectively analyzed for the years 1975-82. The use of gentamicin appears to select out for tobramycin-resistant S. marcescens and gentamicin-, tobramycin-susceptible P. aeruginosa; whereas the use of tobramycin appears to select out for gentamicin-, tobramycin-susceptible S. marcescens and gentamicin-resistant P. aeruginosa.
D004352:Drug Resistance, Microbial; D004363:Drug Utilization; D005839:Gentamicins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012706:Serratia marcescens / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology*
D005839:Gentamicins; D014031:Tobramycin