[Organ distribution of bovine serum albumin administered intragastrically in the rat].
Radioimmunoassay was employed to examine distribution of antigenic structures of bovine serum albumin (BSA), absorbed by the gastrointestinal tract, in the blood serum and organs of intact rats. It was shown that 3 h after administering 3H-BSA an appreciable amount of its antigenic structures could be identified in the blood serum, liver, spleen, and carcass of the animals. The total amount of antigenic determinants of BSA which got into the internal environment of the body from the intestine amounted to about 0.2% of the dose administered. The highest specific content of antigenic structures of BSA supplied via the intestinal barrier was detected in the spleen.
D000818:Animals; D000941:Antigens / Q000032:analysis; D007163:Immunosorbent Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism*; D013270:Stomach; D014018:Tissue Distribution; D014316:Tritium
D000941:Antigens; D014316:Tritium; D012710:Serum Albumin, Bovine
Raspredelenie po organam krys bych'ego syvorotochnogo al'bumina pri ego vnutrizheludochnom vvedenii.