Structure, phosphorylation and desensitization of the insulin receptor in hepatoma cells.
Long-term exposure of rat hepatoma cells to insulin results in a total desensitization of the cells to the action of the hormone. This is characterized by changes in binding and post-binding steps of insulin action, including a decrease in the number and phosphorylation of receptors, and a major modification in receptor oligomerization.
D000818:Animals; D002478:Cells, Cultured; D007328:Insulin / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D010703:Phorbol Esters / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D010766:Phosphorylation; D051381:Rats; D011972:Receptor, Insulin / Q000032:analysis* / Q000378:metabolism
D007328:Insulin; D010703:Phorbol Esters; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D011972:Receptor, Insulin