Kinetics of dark repair inhibition in ultraviolet damaged DNA by substituted quinolines.
The effects of chloroquine on the kinetics of the dark repair process were investigated by employing a cellular system. Lineweaver-Burke plots and Dixon plots of chloroquine inhibition, respectively, showed that there was an increase in slope with increasing concentration of inhibitor which followed an enzyme-like pattern. These results are consistent with a model for excision-repair in which chloroquine may block the excision repair pathway.
D002738:Chloroquine / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000378:metabolism* / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D002738:Chloroquine