Atracurium for short surgical procedures: a comparison with succinylcholine.
A comparison was made between atracurium and succinylcholine in 40 patients undergoing short gynaecological procedures of 30 minutes or less. Good intubating conditions were produced in 76.7 +/- 39.3 seconds (mean +/- S.D.) with succinylcholine 1 mg . kg-1 and 198 +/- 84 seconds with atracurium 400 micrograms . kg-1. Muscle relaxation was maintained with the initial dose of atracurium or with repeated boluses of succinylcholine. The mean time of surgery was 17.65 +/- 5.3 minutes in the atracurium group and 15.2 +/- 4.6 minutes in the succinylcholine group. Residual neuromuscular block with atracurium was reversed with neostigmine 0.036 mg . kg-1 and atropine 0.018 mg . kg-1. Recovery of neuromuscular function following reversal, assessed by return of all responses to train-of-four stimulation occurred in 5.05 +/- 4.6 minutes in the atracurium group but half the above doses of neostigmine and atropine were repeated in three patients. We conclude that a single dose of atracurium 400 micrograms . kg-1 is suitable for intubation and maintainance of muscle relaxation for short surgical procedures. However, the onset of action is slow, compared to succinylcholine. Residual neuromuscular block can be antagonised with standard doses of neostigmine, less than 20 minutes after the initial dose of relaxant. Atracurium appears to be a suitable alternative for short procedures where succinylcholine is unsuitable or contraindicated.
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001279:Atracurium; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*; D009388:Neostigmine / Q000627:therapeutic use; D013390:Succinylcholine / Q000627:therapeutic use*
D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D001279:Atracurium; D009388:Neostigmine; D013390:Succinylcholine