[Defects in the prostaglandin system. V. Inherited (?) disorder of prostacyclin degradation in the plasma (Wien-Döbling defect)].
The case report is presented of a woman of child-bearing age who developed myocardial infarction. An extremely shortened in vitro half-life of PGI2 in plasma was detected in this patient. This new familial defect "Wien-Döbling", in the prostaglandin system might affect an essential coregulator of haemostatic balance in man. It is not known whether this short half-life of PGI2 in vitro is due to accelerated degradation or a failure in stabilization of this biologically active compound.
D000328:Adult; D000368:Aged; D011464:Epoprostenol / Q000097:blood* / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010375:Pedigree; D010978:Platelet Factor 4 / Q000032:analysis; D010979:Platelet Function Tests
D010978:Platelet Factor 4; D011464:Epoprostenol
Defekte im Prostaglandinsystem. V. Vererbte (?) Störung des Prostazyklinabbaus im Plasma (Defekt Wien-Döbling).