Immunocytochemical characterisation of human pituitary adenomas.
Immunohistochemical and histological investigations were undertaken on 24 surgically-removed pituitary adenomas. By histology (haemalu-eosin staining), 7 chromophobe, 12 acidophil and 5 basophil pituitary adenomas were revealed. For immunohistochemical purposes the peroxidase-antiperoxidase technique was applied. Primary antisera against 10 hormones were used. By immunohistochemistry, 7 prolactin-containing, 2 TSH-containing, 2 GH-containing and 1 beta-endorphin-containing pituitary adenomas were identified. Furthermore, 1 mixed thyrotropic-prolactin human pituitary adenoma was detected. A possible connection between histological and immunocytochemical findings is discussed.
D000236:Adenoma / Q000378:metabolism / Q000473:pathology*; D002766:Cholecystokinin / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D009384:Paraneoplastic Endocrine Syndromes / Q000473:pathology*; D010902:Pituitary Gland / Q000473:pathology; D010907:Pituitary Hormones / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology*
D005755:Gastrins; D006729:Hormones, Ectopic; D007328:Insulin; D010907:Pituitary Hormones; D005934:Glucagon; D002766:Cholecystokinin