Use of POR-8 in the management of burned children.
In the paediatric burn unit of Brugmann University Hospital, children are treated conservatively for three weeks before excision and grafting. In order to avoid excessive bleeding during tangential excision of the granulating tissue, sub-eschar infiltration with Para-Ornithin-8-Vasopressin (POR 8), a synthetic neurohypophyseal-like hormone, has been performed since 1979 on 145 children. Bleeding is reduced dramatically by this technique. Therefore, since 1984, infiltration of the donor site with POR 8 was also performed in 25 children. Excision and grafting of areas up to 20% of total body surface are possible in one operation with a graft take rate of 95 to 100%. We didn't record any variation in heart rate. A 5 to 10% increase of arterial blood pressure occurred in all children. No general or local complications have been observed. We believe this technique to be of great help in the operative treatment of burns in children.
D000293:Adolescent; D002056:Burns / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D009951:Ornipressin / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies; D016038:Skin Transplantation; D014667:Vasopressins / Q000627:therapeutic use*
D014667:Vasopressins; D009951:Ornipressin