[Cefmenoxime diffusion into cerebrospinal fluid during human purulent meningitis].
We treated 10 patients with bacterial meningitis by 150 mg/kg/day cefmenoxime divided into six intravenous infusions. CSF samples were taken one hour after an IV on the second and fifth days. CSF cefmenoxime determined by microbiologic assay was 8.3 mg/l on days 2 and 5. Every patient recovered without sequelae. In our opinion, these results may support use of cefmenoxime in bacterial meningitis.
D000328:Adult; D000368:Aged; D015281:Cefmenoxime; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008875:Middle Aged
D015281:Cefmenoxime; D002439:Cefotaxime
Diffusion de la cefménoxime dans le liquide céphalorachidien au cours des méningites purulentes humaines.