Influence of cyproheptadine on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs.
Changes in the coagulation system typical of consumption reaction, microthrombosis in the lungs and other organs and haemodynamic disturbances caused by infusion of endotoxin in weaned pigs were prevented by treatment with the serotonin receptor antagonist cyproheptadine.
D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D010976:Platelet Count; D013552:Swine; D013927:Thrombosis / Q000517:prevention & control; D014886:Weaning
D004731:Endotoxins; D006454:Hemoglobins; D003533:Cyproheptadine; D005337:Fibrin; D005340:Fibrinogen