A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene.
Ground beef contains an organic solvent extractable mutagenesis modulator. Crude or partially-purified preparations of the activity were applied to the backs of SENCAR or CD-1 mice 5 min before application of 7,12-dimethylbenz[a]anthracene (DMBA). Controls received solvent (acetone) only prior to DMBA. Following 1-2 week intervals promotion was effected with twice-weekly applications of 12-O-tetradecanoylphorbol-13-acetate. Modulator-treated mice consistently developed fewer papillomas and exhibited lower tumor incidences than did positive control mice.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000818:Animals; D002417:Cattle; D008460:Meat / Q000032:analysis*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
D009153:Mutagens; D015127:9,10-Dimethyl-1,2-benzanthracene