Prostaglandins act synergistically with antitumour agents on induction of sister chromatid exchanges in human lymphocytes.
Prostaglandins (PGs) E1 and E2 were found to enhance Sister Chromatid Exchange (SCE) frequencies induced by Mitomycin C (MMC) or Melphalan (ME-LPH) in cultured normal human lymphocytes. PG E1, E2 and F2a alone had no effect on SCE induction up to the higher concentration tested of 2 micrograms/ml. PG F2a does not act synergistically with MELPH on induction of SCEs.
D000527:Alprostadil; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D015237:Dinoprost; D015232:Dinoprostone; D004357:Drug Synergism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008558:Melphalan / Q000494:pharmacology; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents; D008937:Mitomycins; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D016685:Mitomycin; D015237:Dinoprost; D000527:Alprostadil; D015232:Dinoprostone; D008558:Melphalan