Rational brain tumor chemotherapy. The interaction of drug and tumor.
This article demonstrates that drug delivery to brain tumors is a function of both drug properties and tumor properties and that both must be considered in planning chemotherapeutic strategies. The range of variability in drug and tumor properties and the effect of each on drug delivery are illustrated.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001783:Blood Flow Velocity; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism; D002199:Capillary Permeability; D006207:Half-Life; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008970:Molecular Weight; D012995:Solubility; D013499:Surface Properties; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents