[Protective effect of two antacids in acute acetylsalicylic acid-induced injuries to the human gastric mucosa].
The present study deals with the protective effect of a pretreatment period with antacids (preparation A = gastropulgit) 50; 1 bag with suspension corresponding to 12.5 g contains: 1 g attapulgite, 1.8 g aluminium hydroxide-magnesium carbonate gel and 0.7 g sorbitol. Reference preparation B = commercial product; 1 bag with suspension corresponding to 10 ml contains: 600 mg magnesium hydroxide and 9 g aluminium hydroxide gel) on the acute acetylsalicylic acid (ASA)-induced lesions of gastric mucosa in man. 8 healthy volunteers received in a double-blind crossover design 1 or 2 bags of the antacids or placebo 15 min prior to 1500 mg p.o. of ASA. Endoscopy was performed 2 h later. In the placebo experiments ASA caused severe lesions in all volunteers (placebo values, study with preparation A: 2.9 +/- 0.1; study with preparation B: 2.8 +/- 0.2). Pretreatment with either one bag reduced the ASA-injuries to 2.2 +/- 0.3) (preparation A) and 2.1 +/- 0.3 (preparation B) (not significant compared with placebo). By contrast, a significant protection of human gastric mucosa against ASA could be achieved with 2 bags of preparation A, but not with 2 bags of preparation B (1.5 +/- 0.3, p less than 0.05; 1.9 +/- 0.3, p less than 0.05). The majority of the volunteers reported less discomfort evoked by ASA under the higher antacid doses.
D000328:Adult; D000863:Antacids / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D008297:Male; D011897:Random Allocation; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000863:Antacids; D001241:Aspirin
Schutzwirkung von zwei Antazida bei akuter Acetylsalicylsäure-Schädigung der menschlichen Magenschleimhaut.