Repair of growing vessels. Continuous absorbable or interrupted nonabsorbable suture?
Twenty 1-month-old piglets were subjected to aortic transection and primary repair either with a posterior-running, anterior-interrupted nonabsorbable suture (group 1) or a circumferential continuous absorbable suture (group 2) technique. Mean piglet weight increased by 886% at six months and 1,184% at nine months. Aortic cross-sectional areas increased by 243% and 340%, respectively. Grossly visible, though minimal, stricture formation was noted in three pigs from group 1 and was associated with an overall 5.8% average anastomotic stricture at six months and 3.5% at nine months in group 1, compared with 0.2% and -0.1%, respectively, in group 2. Adhesion formation, fibrosis, and foreign-body reaction were common in group 1 but negligible in group 2. This corresponded to a mean wall thickness measured at nine months of 2.0 +/- 0.9 mm in group 1 and of 1.0 +/- 0.4 mm in group 2.
D000042:Absorption; D000818:Animals; D001012:Aorta, Abdominal / Q000254:growth & development* / Q000601:surgery; D001672:Biocompatible Materials; D003251:Constriction, Pathologic / Q000209:etiology / Q000503:physiopathology; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D011108:Polymers; D013536:Suture Techniques; D013537:Sutures / Q000009:adverse effects*; D013552:Swine; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology; D014652:Vascular Diseases / Q000209:etiology / Q000473:pathology
D001672:Biocompatible Materials; D011108:Polymers; C046409:polyglyconate