Current status of release of fluoride ions and other bioactive agents from dental materials: prospects for controlled release.
Many kinds of intraoral systems of bioactive agents have been developed. The cariostatic effect of fluoride ions on enamel caries has been demonstrated through numerous clinical studies. In order to maximize the exposure time of fluoride on enamel for improved prevention of dental caries, fluoride compounds were incorporated into various dental materials and other fluoride-releasing devices were made. The application of fluoride-releasing system is accepted as one of effective caries-preventing procedures. The release of other bioactive agents such as antimicrobial agents (antibiotics, chrorhexidines, eugenols, o-ethoxybenzoic acids and nystatins, etc.) and antiinflammatory agents (benzydamine HCl and steroids) from dental materials and devices have also been investigated. In this article, current status of these systems is reviewed and the therapeutic applicabilities are evaluated.
D000269:Adhesives; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology; D002126:Calcium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology; D002327:Cariostatic Agents / Q000008:administration & dosage; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology; D003692:Delayed-Action Preparations; D003723:Dental Amalgam; D003738:Dental Cements; D003764:Dental Materials; D005054:Eugenol / Q000008:administration & dosage / Q000494:pharmacology; D005459:Fluorides / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates / Q000008:administration & dosage / Q000494:pharmacology; D010895:Pit and Fissure Sealants; D012116:Resins, Plant
D000269:Adhesives; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D002327:Cariostatic Agents; D003692:Delayed-Action Preparations; D003738:Dental Cements; D003764:Dental Materials; D062425:Hydroxybenzoate Ethers; D062385:Hydroxybenzoates; D010895:Pit and Fissure Sealants; D012116:Resins, Plant; C015199:ethoxybenzoic acid; D005054:Eugenol; D003723:Dental Amalgam; D002126:Calcium Hydroxide; D005459:Fluorides; D002710:Chlorhexidine