[Endocrine function of the pancreas in tumors of the chiasmal-sellar region].
A clinicobiochemical study of 10 patients with tumors of the chiasmal sellar region and 8 healthy persons using the i. v. glucose tolerance test (IGTT) made it possible to reveal disorder of pancreatic alpha- and beta-cell function in the patients with tumors. A distinct picture of the chiasmal sellar process with the involved hypothalamus was clinically determined in all the patients. Radioimmunoassay of immunoreactive insulin, glucagon, C-peptide and glucose revealed fasting hyperinsulinemia in the presence of both hypo- and hyperglycemia. The latter was accompanied by a raised level of glucagon in the blood. The IGTT revealed in the patients with tumors of the chiasmal sellar region hyperreactivity of beta-cells and a decrease in the sensitivity of alpha-cells to glucose as well as glucose tolerance that may be both regarded as pathogenetic factors of the development of a prediabetic condition in such patients.
D000328:Adult; D003390:Cranial Nerve Neoplasms / Q000503:physiopathology*; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D006946:Hyperinsulinism / Q000209:etiology; D007003:Hypoglycemia / Q000209:etiology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009897:Optic Chiasm; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D011236:Prediabetic State / Q000209:etiology
D007328:Insulin; D005934:Glucagon
Sostoianie endokrinnoĭ funktsii podzheludochnoĭ zhelezy pri opukholiakh khiazmal'no-selliarnoĭ oblasti.