Oral amoxycillin, an alternative treatment for neurosyphilis.
A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus 500 mg probenecid twice a day attained treponemicidal CSF amoxycillin concentrations. Thus amoxycillin by mouth offers an effective alternative method for treating patients with neurosyphilis.
D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage* / Q000134:cerebrospinal fluid / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D009494:Neurosyphilis / Q000188:drug therapy*; D011339:Probenecid / Q000627:therapeutic use; D011817:Rabbits; D014210:Treponema pallidum / Q000187:drug effects
D000658:Amoxicillin; D011339:Probenecid