Antibody response to phenolic glycolipid I in inbred mice immunized with Mycobacterium leprae.
The level of circulating antibody to phenolic glycolipid I of Mycobacterium leprae was determined in 18 inbred strains of mice after immunization with M. leprae organisms. By using a solid-phase radioimmunoassay with phenolic glycolipid I as test antigen, a continuous distribution of antibody levels ranging from high to low was observed. The level was found to be controlled by multiple genes, including both H-2 complex- and Igh allotype complex-linked genes. Low antibody response to phenolic glycolipid I was shown to be inherited as a dominant trait in three combinations of high X low responder F1 progeny.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D000942:Antigens, Bacterial; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D006017:Glycolipids / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics; D007114:Immunization; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D009166:Mycobacterium leprae / Q000276:immunology*; D011863:Radioimmunoassay; D013045:Species Specificity
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D006017:Glycolipids; D006183:H-2 Antigens; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; C045169:phenolic glycolipid I, Mycobacterium leprae