Maturation-inhibiting activity in growing mouse oocytes.
Growing mouse oocytes incompetent to resume meiosis were fused with fully grown immature mouse oocytes and cultured for 20-24 h. In giant cells that developed, two intact germinal vesicles remained well conserved in all cases. We propose that the cytoplasm of growing oocytes possesses a maturation-inhibiting activity which is able to arrest, after fusion, nuclear maturation in fully grown oocytes competent to mature spontaneously.
D000818:Animals; D002459:Cell Fusion; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000502:physiology; D005260:Female; D006133:Growth Substances / Q000096:biosynthesis; D036341:Intercellular Signaling Peptides and Proteins; D016200:Maturation-Promoting Factor; D008540:Meiosis; D051379:Mice; D008805:Mice, Inbred A; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D010455:Peptides / Q000502:physiology*
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C018355:intraovarian peptides; D016200:Maturation-Promoting Factor