[Effect of thyroliberin on pancreatic islet cell function in rats].
A study was made of the TRH effect on insulin and glucagon secretory function of a 4-day neonatal rat pancreatic islet cell culture. The TRH effect was determined in the range of 10-1000 ng/ml concentrations within 30 min and 3 h of cell cultivation with the hormone. TRH stimulated insulin and glucagon secretion within the range of the above doses. No dose dependence was revealed in the TRH stimulation of insulin and glucagon secretion. The data obtained suggest that TRH produces an direct effect on islet cell function stimulating insulin and glucagon secretion.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007328:Insulin; D013973:Thyrotropin-Releasing Hormone; D005934:Glucagon
Vliianie tiroliberina na funktsiiu ostrovkovykh kletok podzheludochnoĭ zhelezy krys.