[Evaluation of the radioprotective effect of total gaseous hypoxia based on the criteria of delayed radiation damage].
Breathing with gas mixture containing 6-8% of oxygen during whole-body and large-field irradiation of mice diminishes the radiation-induced life-span shortening (DMF = 2.2) and decreases the degree of canescence (DMF = 1.5), the frequency and severity of nephro- and cardiosclerosis (DMF = 1.5), and the probability of occurrence of pleura and pericardium edemas provoked by cardiopulmonary insufficiency (DMF = 1.4). The fact that hypoxic hypoxia retains its high radioprotective efficiency in relation to the delayed effects of radiation is important for radiotherapy of tumors.
D000818:Animals; D002588:Cesium Radioisotopes; D005260:Female; D005720:Gamma Rays; D051379:Mice; D009584:Nitrogen; D010100:Oxygen; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013997:Time Factors; D014916:Whole-Body Irradiation
D002588:Cesium Radioisotopes; D009584:Nitrogen; D010100:Oxygen
Otsenka radiozashchitnogo éffekta obshcheĭ gazovoĭ gipoksii po kriteriiami otdalennogo luchevogo porazheniia.