Gastrointestinal absorption of aluminum.
It has recently been documented that a small amount of aluminum is absorbed from a variety of different orally administered aluminum compounds. A variety of factors including gastric acidity, fluoride ingestion, parathyroid hormone, vitamin D and the quantity of aluminum ingested could theoretically modulate aluminum absorption from the gastrointestinal tract. However, partially because of the unavailability of an aluminum isotope, knowledge regarding factors which modify aluminum absorption is quite limited. In healthy individuals the absorbed aluminum is largely eliminated from the body by the kidneys. However, with renal failure the absorbed aluminum is retained and can markedly alter the body aluminum burden with resulting toxicity. In view of this finding, it is suggested that uremic patients receive the smallest amount possible of aluminum-containing, phosphate-binding gels consistent with the control of serum phosphorus levels and that alternate methods for the control of the serum phosphorus should be sought.
D000042:Absorption; D000535:Aluminum / Q000378:metabolism*; D004347:Drug Interactions; D005459:Fluorides / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D012995:Solubility; D014511:Uremia / Q000378:metabolism
D010281:Parathyroid Hormone; D000535:Aluminum; D005459:Fluorides