HLA and genetic predisposition to lupus erythematosus and other dermatologic disorders.
Human leukocyte antigen (HLA) associations with different clinical and serologic subsets of lupus erythematosus are providing important clues to genetic predisposition and pathogenesis. The evolving complexity of the HLA-D region is described, and currently recognized HLA-region associations with systemic lupus erythematosus, subacute cutaneous lupus erythematosus, homozygous C2-deficient lupus, Sjögren's syndrome, and the neonatal lupus syndrome are reviewed. The striking relationship between the Ro/SSA-La/SSB antibody responses and HLA-DR2 and DR3 are emphasized. Other dermatologic conditions associated with HLA are also noted.
D000328:Adult; D000818:Animals; D001324:Autoantigens / Q000032:analysis; D003175:Complement C2 / Q000172:deficiency; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008179:Lupus Erythematosus, Discoid / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012859:Sjogren's Syndrome / Q000235:genetics*; D012871:Skin Diseases / Q000235:genetics*; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001324:Autoantigens; D003175:Complement C2; D006680:HLA Antigens; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human