Biochemical effects of L-deprenyl in atypical depressives.
To examine the biochemical effects of 10-30 mg/day L-deprenyl, measurement of 24-hr urinary output of phenylethylamine (PEA), 3-methoxy 4-hydroxy phenylethyleneglycol (MHPG), and L-deprenyl's amphetamine metabolites were carried out before and during the treatment of atypical depressives. Platelet monoamine oxidase (MAO) activity was also assessed. With L-deprenyl 10-30 mg/day, the expected MAO B inhibition occurred, as indicated by significant increase in urinary PEA excretion and virtual disappearance of platelet MAO activity. Twenty-five to 33% of the daily dose of L-deprenyl was recovered as urinary methamphetamine or amphetamine. Excretion of MHPG was significantly decreased with L-deprenyl 10-20 mg/day. Overall, the results suggest that L-deprenyl's antidepressant effects are mediated by some mechanism other than, or in addition to, MAO B inhibition.
D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000201:enzymology / Q000523:psychology; D003913:Dextroamphetamine; D004305:Dose-Response Relationship, Drug; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D010627:Phenethylamines / Q000627:therapeutic use* / Q000652:urine*; D012642:Selegiline / Q000627:therapeutic use*
D006018:Glycols; D010627:Phenethylamines; D012642:Selegiline; C029261:phenethylamine; D008734:Methoxyhydroxyphenylglycol; D008995:Monoamine Oxidase; D003913:Dextroamphetamine