Effects of oestradiol-17 beta on peripheral plasma concentrations of LH and FSH in ovariectomized tammars (Macropus eugenii).
Two experiments, each using 8 animals, were conducted in the non-breeding and breeding seasons, respectively, and each animal was injected with 4 different doses of oestradiol benzoate over 4 trials. The resulting physiological concentrations of plasma oestradiol caused depression of both LH and FSH values. The highest dose elicited a biphasic response in LH with a pulse-like surge at 24 h after injection. There was no significant difference between the response of either hormone at the two times of the year and it is concluded that, in tammars, there is no seasonal difference in the responsiveness of the hypothalamus/pituitary to the negative feedback effect of oestradiol.
D000818:Animals; D002369:Castration; D003864:Depression, Chemical; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D004971:Estrus; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D007614:Macropodidae / Q000502:physiology*; D008394:Marsupialia / Q000502:physiology*; D010902:Pituitary Gland / Q000187:drug effects*; D011247:Pregnancy; D012621:Seasons; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone