The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2k strains of mice.
Unprimed female CBA mice do not reject large (10 mm2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2k strains indicates that the nature of the response (i.e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex.
D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005838:Genotype; D006084:Graft Rejection; D006085:Graft Survival; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D006182:H-Y Antigen / Q000276:immunology*; D007108:Immune Tolerance; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen