Mutation affecting resistance of Escherichia coli K12 to nalidixic acid.
A new mutation, nalD, determining resistance of Escherichia coli to nalidixic acid (NAL) is reported. The nalD mutant described is resistant to NAL at 37 degrees C but sensitive at 30 degrees C. It is defective in penetration of NAL and glycerol through the outer membrane at 37 degrees C. The nalD mutation is located half-way between 89 and 89.5 min on the E. coli genetic map.
D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects; D002874:Chromosome Mapping; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000096:biosynthesis; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D009154:Mutation; D009268:Nalidixic Acid / Q000378:metabolism / Q000494:pharmacology*
D004269:DNA, Bacterial; D009268:Nalidixic Acid