Pharmacokinetic study of ceftazidime in bone and serum of patients undergoing hip and knee arthroplasty.
Twenty-eight patients undergoing hip arthroplasty and 15 undergoing knee arthroplasty, received chemoprophylaxis with ceftazidime 1.0 g administered intravenously at the time of induction of anaesthesia, followed by two doses of 500 mg given intramuscularly 6 and 12 h later. The mean bone concentration in hip arthroplasty showed a general rise towards a maximum of approximately 20 mg/kg when the exposure time (interval between antibiotic injection and removal of bone sample) was 35-40 min, with values ranging from 4.4 to 21.2 mg/kg (mean 14.4 mg/kg). The patients undergoing knee arthroplasty present a complicated pharmacokinetic problem, as the use of a tourniquet limits the exposure time. Bone concentrations of ceftazidime were highest at sampling times greater than 20 min in these patients (mean level of 15.9 mg/kg for femoral bone and 13.1 mg/kg for tibial bone).
D000328:Adult; D001842:Bone and Bones / Q000378:metabolism*; D002442:Ceftazidime / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use*; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007700:Kinetics; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D011292:Premedication
D002442:Ceftazidime