[Capacity of bone marrow cells to restore thrombocytopoiesis in lethally irradiated animals].
A study was made of the kinetics of thrombocytopoiesis restoration in lethally irradiated mice after transplantation to them of the donor marrow cells. In the initial period, the thrombocytopoiesis restoration is provided by transite cells-precursors of megakaryocytes present in the transplanted bone marrow; the subsequent restoration is due to cells of the self-maintaining population. The level of restoration does not correlate with the number of polypotent cells that form macrocolonies in the spleen of irradiated recipients.
D000818:Animals; D001792:Blood Platelets / Q000528:radiation effects*; D001853:Bone Marrow / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D002455:Cell Division / Q000528:radiation effects; D006410:Hematopoiesis / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010976:Platelet Count / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood*; D013997:Time Factors
Izuchenie sposobnosti kletok kostnogo mozga vosstanavlivat' trombotsitopoéz u lethal'no obluchennykh zhivotnykh.