Low cyclosporin A blood levels and acute graft rejection in a renal transplant recipient during rifampin treatment.
Cyclosporin A trough blood levels were unusually low during rifampin treatment in a kidney transplant patient. Simultaneously, acute graft rejection occurred. Pharmacokinetic investigation revealed a rapid turnover of cyclosporin A leading to low blood levels. Cessation of rifampin therapy reversed these changes. Rifampin substantially reduces the bioavailability of cyclosporin A and should not be used in transplant recipients on cyclosporin A.
D000328:Adult; D001682:Biological Availability; D003524:Cyclosporins / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D016030:Kidney Transplantation; D012293:Rifampin / Q000009:adverse effects* / Q000627:therapeutic use; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
D003524:Cyclosporins; D012293:Rifampin