Queen Elizabeth I: a case of testicular feminization?
The purpose of this paper is to provide support for the hypothesis that Queen Elizabeth I was a case of testicular feminization (male pseudohermaphroditism) and for the explanation of her contemporaries and of some historians, that she never married because of some congenital defect. The phenotypical characteristics of the testicular feminization syndrome are strikingly similar to descriptions of Elizabeth's appearance, personality, behaviour, and particularly, to those physical defects which her contemporaries believed made her sterile and unwilling to marry. Modern historians have rejected the "physical defect" explanation of Elizabeth's refusal to marry in favour of a "psychological" explanation. The basic premise of the "psychological" explanation, that Elizabeth was physically capable of bearing children is unsound for a number of reasons. Recent advances in our understanding of the process of sexual differentiation, particularly, the description of the testicular feminization syndrome, justify a re-evaluation of the "physical defect evidence" of Elizabeth's contemporaries.
D013734:Androgen-Insensitivity Syndrome / Q000266:history*; D004739:England; D005197:Famous Persons; D049669:History, 16th Century; D006801:Humans