Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin.
A prospective randomized trial comparing hyperbaric oxygen and systemic antibiotics in the prevention of osteoradionecrosis was presented. The results indicated, in a high-risk population who required tooth removal in irradiated mandibles, that up-front hyperbaric oxygen produced an incidence of osteoradionecrosis of 5.4% as compared with the antibiotic group of 29.9% (P = .005). Hyperbaric oxygen should be considered a prophylactic measure when post-irradiation dental care involving trauma to tissue is necessary.
D002986:Clinical Trials as Topic; D006801:Humans; D006931:Hyperbaric Oxygenation; D008334:Mandible / Q000528:radiation effects; D008336:Mandibular Diseases / Q000517:prevention & control*; D010025:Osteoradionecrosis / Q000517:prevention & control*; D010400:Penicillin G / Q000627:therapeutic use*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000517:prevention & control*; D011897:Random Allocation; D012306:Risk; D013997:Time Factors; D014081:Tooth Extraction / Q000009:adverse effects; D014945:Wound Healing
D010400:Penicillin G