Demonstration of gastrin/cholecystokinin-like immunoreactivity in the arcuate nucleus, median eminence and pituitary of the guinea pig.
In the brains of colchicine-treated guinea pigs, antibodies directed against the C-terminal sequence of cholecystokinin octapeptide (CCK-8) and cross-reacting with gastrin, visualized a dense population of cell bodies in the arcuate nucleus, periportal nerve endings in the external layer of the median eminence and a few fibers in the neurohypophysis. In the adenohypophysis, at least the major part of corticomelanotrophs were labelled. Immunostainings are compared to those reported in the rat.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000032:analysis*; D002766:Cholecystokinin / Q000032:analysis* / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D005755:Gastrins / Q000032:analysis* / Q000276:immunology; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D008297:Male; D008473:Median Eminence / Q000032:analysis*; D010902:Pituitary Gland / Q000032:analysis*; D010903:Pituitary Gland, Anterior / Q000032:analysis; D010904:Pituitary Gland, Posterior / Q000032:analysis
D005755:Gastrins; D002766:Cholecystokinin