A new H+ suppressor: RP 40 749 versus placebo and cimetidine. Ambulatory 48-hour intragastric pH monitoring in normal men.
Six normal male test persons had nasogastric glass electrodes placed in the antrum for four periods of 48 h each, separated by wash-out periods of 9 days. The electrodes were connected to a portable pH-monitoring system enabling continuous pH recording and storing during and after four different drug or placebo treatments arranged in a double-blind, cross-over experimental design. Data were read out and stored in a computer for later analysis. RP 40 749, a new gastric acid secretion inhibitor acting within the parital cell, raised the median 24-h intragastric pH significantly not only during medication but also during the day after its discontinuation. It also proved to be a significantly more potent H+ suppressor than cimetidine. The same was true for inhibition of nocturnal intragastric acidity, for which cimetidine seemed comparably ineffective. The efficacy of RP 40 749 is comparable to that of omeprazole.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D010919:Placebos; D011897:Random Allocation; D013607:Tablets; D013876:Thiophenes / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D010919:Placebos; D013607:Tablets; D013876:Thiophenes; C034498:RP 40749; D002927:Cimetidine