Limitations of a histologic assay for syn-, allo-, and xenogeneic H-Y antigen.
In view of the potential significance of the H-Y antigen in the etiology of cases of sexual ambiguity we have attempted to develop a clinically useful test for the presence of H-Y on the cells of such patients. The attempts were directed at the detection of accelerated or decelerated rejection of syngeneic skin grafts on H-Y-incompatible mice previously exposed to H-Y positive syngeneic, allogeneic, or xenogeneic cells. Using a simple and rapid histologic assay after exposure to syn- or allogeneic cells, acceleration (sensitization) as well as deceleration (tolerance) was readily demonstrable. However, the assay was not helpful with the use of xenogeneic (rabbit, human) cells.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D006084:Graft Rejection; D006182:H-Y Antigen / Q000032:analysis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic
D006182:H-Y Antigen