Therapy of critically ill postoperative patients based on outcome prediction and prospective clinical trials.
An objective physiologic approach to therapy of high-risk postoperative patients was developed using survival as the criterion to determine the relative importance of variables and optimal goals for these variables. A protocol, based on a branch chain decision tree, also was developed from outcome data. When tested prospectively against the standard of care, this protocol markedly reduced mortality and morbidity.
D002319:Cardiovascular System / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003422:Critical Care; D003657:Decision Making; D003662:Decision Theory; D006439:Hemodynamics; D006801:Humans; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010347:Patient Care Planning; D011183:Postoperative Complications / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D011446:Prospective Studies; D012137:Respiratory System / Q000503:physiopathology; D012720:Severity of Illness Index; D013312:Stress, Physiological / Q000503:physiopathology
D010100:Oxygen