[Mechanism of the antimutagenic action of interferon: the capacity to protect the human cellular repair system].
It has been shown that premutagenic treatment with leukocytic interferon (10, 100 IU/ml) of human peripheral blood lymphocytes cultivated in vitro at the G1-stage of the mitotic cycle results in different cell response to gamma-radiation in doses of 0.5, 1, 2, 4 Gy according to chromosome aberration. The antimutagenic effect failed to be attained with the doses 0.5 and 1 Gy, being maximal at the dose 2 Gy. According to sister chromatid exchanges (SCE) cell pretreatment with interferon leads to a reduction in the effect of gamma-radiation at the dose 2 Gy to the level obtained in the cells after exposure to interferon. In experiments with 4-nitroquinoline-I-oxide, there was a significant decrease in the number of SCE in interferon-treated cells.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects* / Q000528:radiation effects; D009154:Mutation; D010835:Phytohemagglutinins / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects
D007370:Interferon Type I; D010835:Phytohemagglutinins; D015112:4-Nitroquinoline-1-oxide; D001973:Bromodeoxyuridine
K mekhanizmu antimutagennogo deĭstviia interferona: sposobnost' zashchishchat' sistemu reparatsii keltok cheloveka.