[Results of animal experimentation activities at the Institut Marchoux in Bamako (1982-1984)].
The Institut Marchoux animal research unit report of activities 1982-1984 shows increasing results in mouse-foods-pads inoculations. Among 17 multibacillary cases, 16 were clinically dapsone-resistant suspected. In 9 cases there was no multiplication; however in 4 cases, multiplication were observed in the untreated controled mice group but no multiplication in dapsone groups. Three cases were fully dapsone-resistant in all concentrations tested. In one case we have detected a partial DDS resistance. No multiplication in the mice group with 10(-2) dapsone dict, but multiplication in 10(-3) and 10(-4) dapsone dict.
D000818:Animals; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice
D003622:Dapsone
Bilan d'activité de l'animalerie expérimentale de l'Institut Marchoux de Bamako (1982-1984).