The effect of 6-OHDA lesions of the lateral septum on schedule-induced polydipsia.
In this study the relationship between 6-hydroxydopamine lesions of dopaminergic innervation of the lateral septum and schedule-induced polydipsia was examined. Animals with lesions were found to have a significant increase in water intake during a test involving an intermittent schedule of food delivery. Additional experiments with these animals showed that lesions had no effect on: (i) spontaneous drinking, the amount of drinking after 24 h food or water deprivation, water intake following a hypertonic saline challenge; (ii) eating behavior with or without food deprivation; and (iii) spontaneous locomotor activity. This increase in adjunctive behavior is discussed in the light of an enhanced frustrative effect induced by the septal lesions.
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D005639:Frustration; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D012055:Reinforcement Schedule; D012688:Septum Pellucidum / Q000187:drug effects* / Q000378:metabolism; D014868:Water Deprivation
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D004298:Dopamine