Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms.
A human complementary DNA clone specific for the alpha-chain of the T-cell receptor and a panel of rodent X human somatic cell hybrids were used to map the alpha-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the alpha-chain gene to region 14q11q12, which is consistently involved in translocations and inversions detectable in human T-cell leukemias and lymphomas. Thus, the locus for the alpha-chain T-cell receptor may participate in oncogene activation in T-cell tumors.
D000818:Animals; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007137:Immunoglobulin alpha-Chains / Q000235:genetics*; D007938:Leukemia / Q000235:genetics; D008223:Lymphoma / Q000235:genetics; D051379:Mice; D009693:Nucleic Acid Hybridization; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013601:T-Lymphocytes; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains; D011948:Receptors, Antigen, T-Cell; D004247:DNA