[Oxygen metabolic characteristics in the tumor process].
The data available in literature and results of the authors, own investigations on the oxygen metabolism during the appearance and development of the tumour process are presented. The important role of biological oxidation disorders in cell malignancy is discussed. The appearance and development of malignant tumours occur against a background of tissues hypoxia. Severe hypoxia and anoxia are observed constantly in the tumour tissue. Some mechanisms of hypoxia development and cell respiration reduction in malignant tumours are considered. Necessity of methods and drugs searching (antihypoxic agents and antioxidants) for correction of oxygen homeostasis disturbances and increase of antitumour resistance of the organism is substantiated.
D000818:Animals; D002199:Capillary Permeability; D002273:Carcinogens / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism; D002952:Citric Acid Cycle / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000139:chemically induced / Q000378:metabolism*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption; D010313:Partial Pressure; D013482:Superoxide Dismutase / Q000378:metabolism
D002273:Carcinogens; D010088:Oxidoreductases; D013482:Superoxide Dismutase; D005947:Glucose
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