Histological changes in rat bronchus-associated lymphoid tissue after administration of five different antigens.
Histological changes in bronchus-associated lymphoid tissue (BALT) following single intratracheal administration of five different antigens were studied in the rat. After administration of T-dependent antigens (i.e., horseradish peroxidase, bovine serum albumin, and Bacillus Calmette Guérin) only minor changes in BALT in the rat occurred. Intratracheal administration of a T-independent antigen (lipopolysaccharide) and a partly T-independent antigen (paratyphoid vaccine) resulted after 1 week in an increase in cytoplasmic IgM-containing (cIgM) blast cells and plasma cells; these appeared to enter via the high endothelial venules (HEV). After 6 weeks, germinal centers were seen.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D000955:Antigens, T-Independent; D001980:Bronchi / Q000276:immunology* / Q000473:pathology; D006735:Horseradish Peroxidase / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008221:Lymphoid Tissue / Q000276:immunology* / Q000473:pathology; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012710:Serum Albumin, Bovine; D014132:Trachea; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology
D000941:Antigens; D000955:Antigens, T-Independent; D008070:Lipopolysaccharides; D014436:Typhoid-Paratyphoid Vaccines; D012710:Serum Albumin, Bovine; D006735:Horseradish Peroxidase