Kinetic evaluation of four Factor VIII concentrates by model-independent methods.
Single-dose kinetics of 4 Factor VIII concentrates (Kryobulin, Hemofil T, Koate, cryoprecipitate) were studied in 41 patients with haemophilia-A. Model-independent methods were adopted for calculating the kinetic parameters (area under the curve, clearance, area under the moment curve, mean residence time, volume of distribution at steady-state). No substantial difference was observed in the kinetic characteristics of the 4 Factor VIII concentrates. A considerable interindividual variability of the calculated kinetic parameters was demonstrated for all concentrates. Our findings support the need to individualize Factor VIII dosage.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005169:Factor VIII / Q000378:metabolism* / Q000627:therapeutic use; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008956:Models, Chemical; D013997:Time Factors
D005169:Factor VIII