Genetic mapping and characterization of Pseudomonas aeruginosa mutants that hyperproduce exoproteins.
We isolated two mutants of Pseudomonas aeruginosa PAO with defective iron uptake. In contrast to the wild-type strain, the mutants produced extracellular protease activity in media containing high concentrations of salts or iron and hyperproduced elastase, staphylolytic enzyme, and exotoxin A in ordinary media (Xch mutants). The mutations were located in the 55' region of the chromosome, between the markers met-9011 and pyrD.
D001426:Bacterial Proteins / Q000096:biosynthesis*; D002874:Chromosome Mapping; D005098:Exotoxins / Q000096:biosynthesis*; D009154:Mutation; D010196:Pancreatic Elastase / Q000096:biosynthesis; D010447:Peptide Hydrolases / Q000096:biosynthesis; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000378:metabolism
D001426:Bacterial Proteins; D005098:Exotoxins; D010447:Peptide Hydrolases; D010196:Pancreatic Elastase