Bronchospasm following intravenous injection of ionic and non-ionic low-osmolality contrast media.
Eighty patients were given either intravenous Hexabrix 320 or Niopam 300 for urography, and any bronchospastic effect was assessed by measurement of forced expiratory volume in 1 s (FEV1). No significant difference between pre- and post-injection FEV1 was shown with either contrast medium. Minor side-effects were comparable, the only significant difference between the two being the higher incidence of nausea and vomiting with Hexabrix 320.
D000328:Adult; D000368:Aged; D001986:Bronchial Spasm / Q000139:chemically induced*; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007275:Injections, Intravenous; D007477:Ions; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D007485:Ioxaglic Acid; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D011897:Random Allocation; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014567:Urography / Q000379:methods
D003287:Contrast Media; D007477:Ions; D014283:Triiodobenzoic Acids; D007483:Iothalamic Acid; D007479:Iopamidol; D007485:Ioxaglic Acid