Cutaneous, ocular, and osteoarticular candidiasis in heroin addicts: new clinical and therapeutic aspects in 38 patients.
Of 38 heroin addicts treated for systemic candidal infections, 36 had metastatic cutaneous lesions (deep-seated scalp nodules and pustulosis in hairy zones), 15 had ocular localizations (mainly chorioretinitis), and 10 had osteoarticular involvement (vertebrae, costal cartilage, knees, and sacroiliac). Such cutaneous lesions have not previously been described in classical systemic candidiasis; we also observed hair invasion by candidal hyphae. Candida albicans was the exclusive species isolated, in contrast to other visceral candidiases in heroin addicts. All isolates were sensitive to amphotericin B, flucytosine, and ketoconazole. Thirty-one visceral localizations were treated only with ketoconazole. Results were favorable in 15 of 18 cutaneous, 6 of 6 ocular, and 4 of 7 osteoarticular cases of involvement. This outbreak coincided with introduction of a new heroin on the drug market in the Paris area. C. albicans was not isolated from the drug. Pathogenesis of this syndrome is unclear.
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001847:Bone Diseases / Q000209:etiology; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D002179:Candidiasis, Cutaneous / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D005602:France; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000209:etiology; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000209:etiology; D012535:Scalp; D013577:Syndrome
D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole