Is cyclosporine's nephrotoxicity related to its immunosuppressive effectiveness?
A fatal early acute rejection occurred in a heart allograft recipient immunosuppressed with Cyclosporine. This failure to prevent rejection in spite of satisfactory plasma levels of Cyclosporine was associated with total absence of renal impairment. The latter has always been present in our experience. The absence of immune and nephrotoxic effects raises the question of a biological defect in this patient, possibly a lack of specific receptors for Cyclosporine.
D003524:Cyclosporins / Q000009:adverse effects* / Q000097:blood / Q000494:pharmacology; D006084:Graft Rejection / Q000187:drug effects; D016027:Heart Transplantation; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011971:Receptors, Immunologic / Q000172:deficiency / Q000276:immunology; D014181:Transplantation Immunology
D003524:Cyclosporins; D011971:Receptors, Immunologic; C028752:cyclosporin receptor