Effect of repeated lepromin testing on experimental nine-banded armadillo leprosy.
Twenty-eight armadillos were lepromin tested and infected with M. leprae; 18 intravenously and 10 intradermally. The lepromin test was repeated after 3 months and at intervals of 6 months thereafter until their death or sacrifice up to 30 months. The one animal with tuberculoid lepromin was resistant and 14 of the 16 with lepromatous lepromin developed generalized disease. Of the 11 with borderline lepromin, 6 developed disseminated disease and 5 were resistant. There is a definite relationship between resistance and tuberculoid lepromin in the armadillo. Repeated lepromin testing had no effect in the rate of infection and the course of the disease in animals infected intravenously. In the intradermally infected animals the results were inconclusive. Whereas all the 20 animals with disseminated disease showed lesions in the liver, spleen and lymph nodes, only 4 animals had sciatic nerve involvement. Peripheral nerve trunk is not necessarily the preferred site in the armadillo. Lung lesions were an important cause of death in lepromatous armadillos.
D000818:Animals; D001135:Armadillos; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007916:Lepromin / Q000276:immunology; D007918:Leprosy / Q000276:immunology* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009166:Mycobacterium leprae / Q000276:immunology
D007916:Lepromin