Plasma six-keto-prostaglandin F1 alpha and endocrine pancreatic function in the newborn infant of the diabetic mother.
Plasma concentrations of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), C-peptide and pancreatic glucagon and blood glucose levels were measured in 13 infants of insulin-dependent diabetic mothers at the age of 2 h. Plasma 6-keto-PGF1 alpha levels were lower in these infants when compared to those of healthy controls at the same age (p less than 0.05). Plasma 6-keto-PGF1 alpha correlated negatively with the C-peptide levels (r = -0.57; p less than 0.05) and positively with the pancreatic glucagon concentrations (r = 0.83; p less than 0.001) in the infants of diabetic mothers. No correlation with blood glucose concentrations was found. The data suggest that hyperinsulinemia in infants of diabetic mothers is associated with a decreased vascular prostacyclin production.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D011464:Epoprostenol / Q000502:physiology; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000502:physiology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*
D001786:Blood Glucose; D002096:C-Peptide; D015121:6-Ketoprostaglandin F1 alpha; D005934:Glucagon; D011464:Epoprostenol