A clinical trial using co-trimoxazole in an attempt to reduce wound infection rates in dog bite wounds.
One hundred and thirteen patients were entered into a randomized, prospective double-blind, placebo controlled trial to assess the use of co-trimoxazole in reducing wound infections after dog bites. Although there was a reduction in the wound infection rate from 13.8% in the placebo group to 5.5% in the treatment group this did not reach statistical significance (P = 0.135). If hand wounds are considered separately, no infections occurred in the treatment group and a benefit seems likely.
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001733:Bites and Stings / Q000150:complications*; D002986:Clinical Trials as Topic; D004285:Dogs; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D004341:Drug Evaluation; D006230:Hand Injuries / Q000150:complications; D006801:Humans; D011446:Prospective Studies; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014946:Wound Infection / Q000517:prevention & control*
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole