Dopamine D-2 receptor-mediated excitation of caudate nucleus neurons from the substantia nigra.
Microiontophoretic studies using cats anesthetized with alpha-chloralose were performed to elucidate whether the excitatory response of caudate nucleus (CN) neurons upon stimulation of the pars compacta of the substantia nigra (SN) is mediated by the dopamine D-1 or D-2 receptor. There were rare convergent inputs from the SN and motor cortex (MC) in the CN neurons. Iontophoretic application of haloperidol and domperidone (dopamine D-2 receptor antagonist) produced dose-dependent inhibition of spikes elicited by SN stimulation in 25 of 42 and 50 of 82 CN neurons, respectively, however, no alterations of spikes elicited by MC stimulation occurred in any 11 neurons tested. Iontophoretically applied SCH 23390 (D-1 antagonist) did not inhibit the SN-induced spikes in any CN neurons, of which spikes were inhibited by domperidone. These results suggest that the SN-induced spikes are mediated by dopamine, which acts on postsynaptic D-2 receptors.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D002415:Cats; D002421:Caudate Nucleus / Q000166:cytology* / Q000502:physiology; D004294:Domperidone / Q000494:pharmacology; D004558:Electric Stimulation; D004594:Electrophysiology; D006220:Haloperidol / Q000494:pharmacology; D007478:Iontophoresis; D009474:Neurons / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D013378:Substantia Nigra / Q000166:cytology* / Q000502:physiology; D013997:Time Factors
D001552:Benzazepines; D011954:Receptors, Dopamine; D004294:Domperidone; D006220:Haloperidol