[Effect of subtotal small intestine resection on insulin and glucagon secretion by the isolated perfused rat pancreas following glucose stimulation].
An attempt has been made to investigate possible regulatory effects of gastrointestinal hormones on insulin and glucagon secretion in Wistar rats that had been subjected to partial resection of the duodenum and jejunum or the ileum. Release of insulin and glucagon was studied on perfused pancrease 4 weeks after the operation. Partial resection of both the duodenum and jejunum resulted in a significant decrease of glucose-induced insulin secretion and basal glucagon release when compared with the controls. Glucagon release was not further suppressed by increasing glucose concentration in the perfusion medium. Resection of the ileum only had no effects. Also, there was no difference to be observed in plasma insulin levels between the two groups. Resection of the ileum, however, provoked a drastical decrease of plasma insulin levels. Food intake was not significantly changed while body weight slightly decreased 1 week after operation but returned to normal after 4 weeks. The results suggest that the various parts of the small intestine seem to be involved in the regulation of glucose-stimulated insulin secretion as well as basal glucagon release. The alterations in glucose-stimulated insulin or glucose-suppressed glucagon secretion are likely due to the action of gastrointestinal hormones or hitherto unknown peptides.
D000818:Animals; D005260:Female; D005768:Gastrointestinal Hormones / Q000502:physiology; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007421:Intestine, Small / Q000502:physiology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D005768:Gastrointestinal Hormones; D007328:Insulin; D005934:Glucagon; D005947:Glucose
Zur Wirkung einer subtotalen Dünndarmresektion auf die Insulin- und Glukagonsekretion des isoliert perfundierten Pankreas der Wistar-Ratte nach Glukosestimulation.