Gossypol, a potent inhibitor of arachidonate 5- and 12-lipoxygenases.
Gossypol inhibited 5- and 12-lipoxygenases of rat basophilic leukemia (RBL-1) cells with ID50 of 0.3 microM and 0.7 microM, respectively. Nearly two orders of magnitude of higher concentration of gossypol was required to inhibit prostaglandin synthetase. The inhibition was of a non-competitive type with respect to arachidonate.
D000818:Animals; D001091:Arachidonate Lipoxygenases; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001491:Basophils; D016861:Cyclooxygenase Inhibitors; D006072:Gossypol / Q000494:pharmacology*; D007938:Leukemia / Q000201:enzymology; D016859:Lipoxygenase Inhibitors; D051381:Rats
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D016718:Arachidonic Acid; D001091:Arachidonate Lipoxygenases; D006072:Gossypol