Comparative study of two iodinated contrast media containing 20% iodine in lower-limb phlebography: ioxaglate versus a conventional product.
Forty-eight patients were examined by bilateral ascending phlebography in a crossover, prospective, randomised, double-blind study. A low-osmolar agent (Hexabrix) (ioxaglate, 200 mg iodine/ml) and a dilute conventional contrast medium (Angiografin) (meglumine diatrizoate) with the same iodine concentration were used for each limb alternately. The adverse reactions and the quality of diagnostic data were recorded: the Student paired-t-test showed statistically that ioxaglate containing 200 mg iodine per ml was better tolerated and that diagnostic information was equally good for the deep and ilio-caval systems, but seemed better with diatrizoate for superficial veins with extensive varicosity. The authors conclude that ioxaglate 200 is advantageous overall in lower-limb phlebography from the standpoints of tolerance, diagnostic data and cost.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D007463:Iodobenzoates; D007485:Ioxaglic Acid; D007866:Leg / Q000098:blood supply*; D008875:Middle Aged; D010690:Phlebography; D011446:Prospective Studies; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D011897:Random Allocation; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014648:Varicose Veins / Q000000981:diagnostic imaging
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007485:Ioxaglic Acid