The influence of thymosin (TEX) on antigen-induced primary and secondary antibody responses of mice.
Thymosin (TFX) administered in mice does not alter their primary IgM humoral responses, while it significantly increases the number of IgG plaque-forming cells and IgM PFC during the secondary response. In the thymectomized mice, thymosin partially restores primary and secondary IgM responses, but IgM production remains low.
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D013934:Thymectomy; D013947:Thymosin / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; C019108:TFX; D013949:Thymus Extracts; D013947:Thymosin