In vitro insulin effect on acetylcholine esterase of erythrocyte membranes of normal and diabetic rats.
Alloxan induced diabetes in rats was associated with a significant reduction in the acetylcholine esterase activity of the erythrocyte membrane. Preincubation of these membranes with insulin caused a rapid but transient stimulation of this enzyme activity in both normal and diabetic rats, the effect being more marked in the latter group.
D000110:Acetylcholinesterase / Q000097:blood*; D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D004910:Erythrocyte Membrane / Q000201:enzymology*; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007328:Insulin; D000496:Alloxan; D000110:Acetylcholinesterase