The effect of lactacidemia on regional cerebral blood flow in the newborn dog.
The effects of lactacidemia on regional cerebral blood flow (rCBF) were determined in newborn dogs using [14C]iodoantipyrine autoradiography. Measurements of rCBF were made in normoxic, normocarbic, normotensive newborn dogs which were paralyzed and passively ventilated with 70% N2O and 30% O2. In 6 dogs rendered lactacidemic by the intravenous infusion of a 2% unneutralized L-lactic acid solution, arterial lactate concentrations increased by 268% while arterial pH decreased to a mean value of 7.105 +/- 0.051. Lactacidemia also increased mean arterial pCO2 values to 48.3 +/- 4.3 Torr from their original pre-infusion levels of 38.8 +/- 3.1 Torr. Although there were apparent increases in rCBF ranging from 26 to 54% above control levels, upon correction of each region's blood flow values for changes in arterial pCO2, there were no statistically significant differences between rCBF in the control and experimental animals. These results suggest that lactacidemia does not directly alter the cerebral circulation of the normoxic newborn dog.
D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000983:Antipyrine / Q000031:analogs & derivatives; D001345:Autoradiography; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D007773:Lactates / Q000097:blood*; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow
D007773:Lactates; D002245:Carbon Dioxide; D010100:Oxygen; D000983:Antipyrine; C008135:iodoantipyrine