Macromolecules mediate prostacyclin release from human umbilical artery.
Previous reports regarding the modulation of prostaglandin release from tissues by serum components did not identify these components. We have found that inhibition of prostacyclin release from human umbilical artery by human serum is attributable to serum macromolecules. We demonstrate that such inhibitory activity depends on macromolecular size and may result from macromolecule/cell surface interactions.
D001158:Arteries / Q000378:metabolism*; D001345:Autoradiography; D001798:Blood Proteins / Q000502:physiology*; D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D008297:Male; D011863:Radioimmunoassay; D014469:Umbilical Arteries / Q000378:metabolism
D001798:Blood Proteins; D046911:Macromolecular Substances; D011464:Epoprostenol