[A fibrin clot containing of anticancer drug for intra-arterial chemo-embolization therapy. (2) Chemotherapeutic effects on a model hepatoma using VX-2 carcinoma in rabbits].
The chemotherapeutic and ischemic effects of a fibrin clot containing mitomycin-C were observed on a model of primary hepatoma using VX-2 carcinoma inoculated in to the subcapsule of the liver of rabbits. The results of antitumor effect suppression of pulmonary and intrahepatic metastases and survival time using the fibrin clot containing mitomycin-C were better than with other treatments, namely a one-shot infusion of MMC or embolization with fibrin clot only. A synergistic antitumor effect was obtained using embolization with the fibrin clot incorporating mitomycin-C. Using direct subcapsular inoculation with a VX-2 carcinoma block a solitary hepatic tumor was obtained which was hypervascular and resembled human primary hepatoma. These results suggested that a fibrin clot containing an anticancer drug is safe a and effective modality for hepatic or other arterial embolization therapies.
D000818:Animals; D002122:Calcium Chloride / Q000008:administration & dosage; D004621:Embolization, Therapeutic; D005340:Fibrinogen / Q000008:administration & dosage*; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D011817:Rabbits; D013917:Thrombin / Q000008:administration & dosage*
D008937:Mitomycins; D016685:Mitomycin; D005340:Fibrinogen; D013917:Thrombin; D002122:Calcium Chloride