Bronchodilator combinations in animals and in man.
Combined bronchodilator effects of the beta 2-agonist pirbuterol and theophylline were studied in anaesthetized rats and in asthmatic outpatients. In rats, pirbuterol was more effective than aminophylline in reducing methacholine-induced bronchoconstriction without counteracting associated hypotension. In combination they caused additive bronchodilatation. In asthmatic patients, the combination pirbuterol + theophylline + hydroxyzine was as effective as the control combination ephedrine + theophylline + hydroxyzine, both differing significantly from the placebo. Thus, a beta 2-agonist may not be superior to ephedrine in these combinations.
D000328:Adult; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations; D004809:Ephedrine / Q000627:therapeutic use*; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains
D001993:Bronchodilator Agents; D004338:Drug Combinations; D004983:Ethanolamines; D004809:Ephedrine; C009118:pirbuterol