Assignment of two Japanese xeroderma pigmentosum patients to complementation group D and their characteristics.
Japanese xeroderma pigmentosum sib patients XP58TO and XP59TO were assigned to complementation group D on the basis of cell hybridization studies. Ultraviolet and 4-nitroquinoline-1-oxide hypersensitivity and reduced unscheduled DNA synthesis of cells of these XP patients were also characteristic of authentic group-D cells. The patients have not yet developed either apparent neuromental abnormalities or skin cancers.
D015112:4-Nitroquinoline-1-oxide; D001345:Autoradiography; D002459:Cell Fusion; D002478:Cells, Cultured; D002648:Child; D002901:Chromosomes, Human, 13-15; D004260:DNA Repair; D004261:DNA Replication / Q000528:radiation effects; D005260:Female; D005816:Genetic Complementation Test; D006801:Humans; D006824:Hybridization, Genetic; D008297:Male; D012871:Skin Diseases / Q000235:genetics*; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics*
D015112:4-Nitroquinoline-1-oxide