Treatment of vaginal candidosis using clotrimazole vaginal cream: single dose versus 3-day therapy.
The effect of using a single dose of 10% clotrimazole cream was compared with that of using a twice-daily application of 2% clotrimazole cream for 3 days in 111 women with mycologically proven vaginal candidosis. The results, analyzed for 55 patients in each group, showed that 1 week after starting treatment, negative cultures were recorded for 91% of the patients who received single-dose therapy and 96% of patients treated with the 3-day regimen. Five weeks after treatment started, the figures were 84% and 81%, respectively, showing that both regimens were equally effective. No adverse events were recorded for either preparation.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001446:Balanitis / Q000188:drug therapy; D002177:Candidiasis / Q000188:drug therapy; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003022:Clotrimazole / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D008297:Male; D013997:Time Factors; D014622:Vaginal Creams, Foams, and Jellies
D007093:Imidazoles; D014622:Vaginal Creams, Foams, and Jellies; D003022:Clotrimazole