[Experimental diarrhea in mice induced by oral infection with an enterotoxigenic strain of E. coli].
It has been shown in experiments on adult random-bred and BALB/c Sto mice that oral infection with human strain of E. coli N-10407 induces enterocolitis characterized by marked diarrheal syndrome but without lethal outcome. The action of the strain not colonizing the intestinal mucosa of mice may be accounted for by a weak cytopathic effect of the infecting microorganism and its toxin. The data obtained indicate that adult mice may serve as a convenient model for investigation of colibacillary diarrhea induced by enterotoxigenic strain of E. coli, BALB/c Sto mice being a more sensitive model than random-bred animals.
D000818:Animals; D003967:Diarrhea / Q000209:etiology*; D004927:Escherichia coli Infections / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C
Eksperimental'naia diareia u mysheĭ, vyzvannaia peroral'nym zarazheniem énterotoksigennym shtammom E. coli.