Dramatic increase of placental protein 5 levels following injection of small doses of heparin.
In the course of an investigation on the effects of thyroid releasing hormone in pregnant women we noted a dramatic increase in the levels of placental protein 5 (PP5) in maternal blood. This increase ranged from 10 times to over 40 times the basal levels. Further study showed that the rise was associated with the use of heparin to maintain the patency of the cannula through which the samples were collected. Furthermore, the phenomenon appeared to be systemic rather than local, and may well be due to a direct effect of heparin on PP5 secretion by the placenta.
D005260:Female; D006023:Glycoproteins; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D006023:Glycoproteins; D011257:Pregnancy Proteins; C021240:tissue-factor-pathway inhibitor 2; D013973:Thyrotropin-Releasing Hormone; D006493:Heparin