Spontaneous and mutagen-induced sister chromatid exchange in motor neurone disease.
Spontaneous and mutagen-induced sister-chromatid exchange frequencies have been studied in the peripheral blood lymphocytes of 6 patients with motor neurone disease. Their values were compared with those obtained in age- and sex-matched healthy controls. No significant differences were observed between the 2 groups. These results do not support the hypothesis of a defect in the repair of DNA damage as the primary abnormality in the development of the disease.
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D002478:Cells, Cultured; D004260:DNA Repair; D004305:Dose-Response Relationship, Drug; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D008937:Mitomycins; D016685:Mitomycin; D005020:Ethyl Methanesulfonate