Relationship of administered dose to blood venom levels in mice following experimental envenomation by Russell's viper (Vipera russelli) venom.
I125 labelled Russell's viper venom was administered i.m. into mice at various doses. Radioactivity in the blood at different intervals was determined and related to the amount injected. A mathematical equation was formulated to represent the relationship of administered dose to blood venom levels. This study suggests that the derivation of such an equation is also possible in humans in order to predict the amount envenomated.
D000818:Animals; D001345:Autoradiography; D002850:Chromatography, Gel; D004305:Dose-Response Relationship, Drug; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007457:Iodine Radioisotopes; D008297:Male; D051379:Mice; D012909:Snake Bites / Q000097:blood*; D013997:Time Factors; D014757:Viper Venoms / Q000008:administration & dosage / Q000097:blood*
D007457:Iodine Radioisotopes; D014757:Viper Venoms