In vitro antituberculosis activity of a new antibacterial substance ofloxacin (DL8280).
A new antituberculosis agent, ofloxacin (DL8280), inhibited the growth of Mycobacterium tuberculosis at concentrations of 0.63 to 1.25 micrograms/ml. There were no cross-resistance relationships between this agent and other antituberculosis agents. The agent delayed the growth rate of M. tuberculosis (strain H37Rv) at concentrations of 0.2 to 0.5 microgram/ml. It showed considerable bactericidal activity at concentrations a little higher than the growth-inhibitory concentration. The combined effect with other antituberculosis agents seemed to be additive. The pattern of resistance that developed with this agent was the obligatory two-step pattern, and there were 2 resistant phenotypes.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D066298:In Vitro Techniques; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D015242:Ofloxacin; D010078:Oxazines / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D010078:Oxazines; D015242:Ofloxacin