A comparative trial of 400 mg cimetidine twice daily and 1000 mg daily in the short-term treatment of duodenal ulceration.
The therapeutic efficacy of cimetidine given as 400 mg twice daily was compared to that of cimetidine given as 1.0 g daily in 4 divided doses (200 mg 3-times daily and 400 mg at night) in two groups of 25 patients (total 50 patients) with active duodenal ulceration. After 4 weeks, healing rates of 72% and 76%, respectively, were observed for the two dosage regimens. Patients who remained unhealed at 4 weeks were treated for a further 4 weeks, after which cumulative healing rates of 84% and 92%, respectively, were obtained. None of the observed differences in healing rates were statistically significant. Symptomatic improvement was similar for the two dosage regimens. No significant adverse reactions were reported.
D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011897:Random Allocation; D013997:Time Factors; D014945:Wound Healing
D002927:Cimetidine