In vitro assessment of sensitivity of Plasmodium falciparum to chloroquine and mefloquine in Ghana.
An in vitro study of sensitivity of Plasmodium falciparum to chloroquine and mefloquine in Ghana is described. Results of 60 short-term cultures from 36 patients are evaluated. No sign of chloroquine resistance was found as all microtests showed complete inhibition of maturation at a level of 0.8 X 10(-6) M. For mefloquine schizont maturation was seen at higher levels of the drug. However, the estimated EC99, with 2.2830 X 10(-6) M is probably within the range of sensitivity.
D000293:Adolescent; D000328:Adult; D000962:Antimalarials; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology*; D005260:Female; D005869:Ghana; D006801:Humans; D008288:Malaria / Q000469:parasitology; D008297:Male; D015767:Mefloquine; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*
D000962:Antimalarials; D011804:Quinolines; D002738:Chloroquine; D015767:Mefloquine