[Histological study of the biocompatibility of hydroxyapatite crystals in periodontal surgery].
The purpose of this investigation was to analyse, after 6 years of clinical trials, the findings obtained from biopsies of infrabony defects in man treated by grafts of hydroxyapatite. Filled extraction sockets in miniature swine treated in a similar manner with apatite were also studied. Light microscope analysis showed bone neoformation around and in the neighbourhood of grafted apatite fragments with the presence of osteocytes, osteoblasts and a normal peripheral connective tissue without inflammatory reaction. These results demonstrate the biocompatibility of the implanted apatites accompanied by a normal fibrogenesis and a seeming osteogenesis.
D000328:Adult; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D001706:Biopsy; D001842:Bone and Bones / Q000187:drug effects* / Q000473:pathology; D003460:Crystallization; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D006882:Hydroxyapatites / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010012:Osteogenesis / Q000187:drug effects; D010519:Periodontium / Q000601:surgery*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D001672:Biocompatible Materials; D006882:Hydroxyapatites
Etude histologique de la biocompatibilité des cristaux d'hydroxyapatite en chirurgie parodontale.