[Randomized controlled trial of postoperative adjuvant chemotherapy with bestatin for gastric cancer].
The effectiveness of Bestatin on the prognosis of gastric cancer patients was investigated in a randomized controlled trial of postoperative adjuvant chemotherapy. One hundred and sixty-two cases of gastrectomized patients were divided into two groups; a Bestatin group (83 cases, 1/2MF'C [mitomycin C 2 mg and cytosine arabinoside 20 mg i.v. twice a week for 3 weeks, FT-207 400 mg/day i.v. for 3 weeks] followed by Bestatin 30 mg/day and FT-207 0.6 g/day p.o.) and a control group (79 cases, 1/2MF'C followed by FT-207 alone). No significant differences in background factors between the two groups were found. Bestatin was slightly effective in improving the three-year survival rates of gastric cancer patients, but this was not significant. However, survival rates in the Bestatin group in Stage II, curatively operated cases, and n (-) ps (+) cases were significantly higher than those of the control group during the same postoperative period. Bestatin prolonged the disease-free interval in curatively resected cases. Thus, efficacy of Bestatin in improving survival rates was observed in the early stages of disease, but it is suggested that combination a stronger chemotherapeutic regimen may be effective in advanced cases.
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003561:Cytarabine / Q000008:administration & dosage; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D011182:Postoperative Care; D011379:Prognosis; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D003561:Cytarabine; D005641:Tegafur; D016685:Mitomycin; D007930:Leucine; C012211:ubenimex