[Synthesis and in vitro antimicrobial activity of N-substituted derivatives of phenylpiperidine and phenylpiperazine].
Synthesis and antimicrobial activity of some N-substituted aza- and diaza-phenylcycloalkanes are reported. All the compounds screened in vitro show significant antibacterial and antimycotic activities. Particularly, compounds of the N-(ethoxymethyl)phenylpiperidine series, show activity towards S. aureus 1,2-1,9 superior to ampicillin. Furthermore the microbiological results indicate that the latter activity depends on the position of the phenyl-substituent.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010879:Piperazines; D010880:Piperidines
Sintesi ed attività antimicrobica in vitro di derivati N-sostituiti di fenilpiperidine e fenilpiperazine.