[Effect of serotonin on the yield of UV-induced thymine dimers in DNA].
Using a fluorescence method the interaction between serotonin and DNA has been investigated and the association constant Kc = 4.2 X 10(4) M-1 was determined. Bound serotonin is shown to reduce the yield of UV-induced thymine dimers in DNA. It is calculated that the value of the effective distance over which each protector acts is a segment of the DNA helix about four base pairs long.
D004269:DNA, Bacterial / Q000378:metabolism / Q000528:radiation effects*; D004926:Escherichia coli / Q000378:metabolism / Q000528:radiation effects; D066298:In Vitro Techniques; D010777:Photochemistry; D011740:Pyrimidine Dimers / Q000378:metabolism / Q000528:radiation effects*; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D011740:Pyrimidine Dimers; D012701:Serotonin
Vliianie serotonina na vykhod UF-indutsirovannykh timinovykh dimerov v DNK.