Intragastric acidity under 28-day omeprazole treatment.
The aim of our study was to investigate both the effect of 28-day treatment with omeprazole (30 mg orally once daily) and of repeated investigations on 24 h intragastric H+ activity. In double-blind randomized order, 10 healthy subjects received omeprazole and 5 placebo. 24 h acidity was determined before, during and after, treatment on days -8, -4, -1, 14 and 28, 32, 36, 42 and 70. A 90% reduction in the 24 h acid concentration was found after 14 and 28 days of treatment. Nocturnal H+ activity was decreased by 85%. No hyperacidity was observed after withdrawal of the drug. Control levels before, (between days -8 and -1) and after, therapy (between days 36 and 70), however, showed a significant increase in 24 h intragastric H+-activity. Summarizing, omeprazole 30 mg mane inhibits gastric acidity markedly both day and night. Repeated investigations at short intervals lead to a significant increase in intragastric acid concentration.
D000328:Adult; D001562:Benzimidazoles / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D009853:Omeprazole; D011897:Random Allocation; D013997:Time Factors
D001562:Benzimidazoles; D009853:Omeprazole