Urinary beta 2-microglobulin and retinol binding protein: individual fluctuations in cadmium-exposed workers.
Urinary retinol binding protein (RBP) and beta 2-microglobulin (beta 2-m) were compared in apparently healthy population groups with and without occupational exposure to cadmium (Cd). The relationship observed in neutral urine was: RBP (micrograms/mmol creatinine) = 0.786 + 0.814 beta 2-m (micrograms/mmol creatinine). This relationship was similar to that reported for patients with various renal diseases [13]. Analysis of urine samples collected weekly from workers exposed occupationally to Cd revealed marked fluctuations, not only in the concentration of the acid-labile beta 2-m but also in the level of the pre-analytically more stable RBP. Therefore, repeated sampling and urine analyses are suggested as means to obtain more reliable data when monitoring Cd-exposed personnel.
D000368:Aged; D002104:Cadmium / Q000633:toxicity*; D004781:Environmental Exposure; D006801:Humans; D008875:Middle Aged; D012177:Retinol-Binding Proteins / Q000652:urine*; D001613:beta 2-Microglobulin / Q000652:urine*
D012177:Retinol-Binding Proteins; D001613:beta 2-Microglobulin; D002104:Cadmium