The detailed conformational study of a leukotriene antagonist, FPL-55712, using high-field nuclear magnetic resonance spectroscopy.
High-field proton magnetic resonance measurements at 400 MHz and 600 MHz allowed the evaluation of the preferred conformations of a leukotriene antagonist, FPL-55712. The experiments involved an analysis of proton-proton coupling constants, longitudinal relaxation time data and nuclear Overhauser effect experiments. The NMR parameters confirm the conformational features expected from X-ray and microwave data for related substances, such as rotational freedom about C14-C15 and C15-C16, synperiplanar arrangements for C7-C8-O-C14 and C16-O-C17-C18 and segmental motion in the propyl side chains.
D002867:Chromones; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D013189:SRS-A / Q000037:antagonists & inhibitors
D002867:Chromones; D013189:SRS-A; C006312:FPL 55712