Changing pattern of resistant Shiga bacillus (Shigella dysenteriae type 1) and Shigella flexneri in Bangladesh.
Shigella dysenteriae type 1 (Shiga bacillus) has made a dramatic comeback in Bangladesh after 10 years when Shigella flexneri was the dominant serogroup. Whereas S. flexneri showed little increase in resistance to the commonly used antimicrobial agents--namely, trimethoprim-sulfamethoxazole (TMP-SMX) and ampicillin-over the years, S. dysenteriae type 1 underwent rapid changes with regard to sensitivity pattern during the last two years. The first TMP-SMX-resistant strain of S. dysenteriae type 1 was detected in September 1982; however, by mid-1984 most strains were resistant while retaining sensitivity to ampicillin. During this period, the ratio of S. flexneri to S. dysenteriae type 1 narrowed from 0.15 to 1. Such propagation of high resistance to TMP-SMX might have been due to widespread use of the drug imported into the country in large quantities. Resistance to ampicillin is increasing rapidly, particularly in S. dysenteriae type 1.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000667:Ampicillin / Q000494:pharmacology; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007223:Infant; D010403:Penicillin Resistance; D012762:Shigella dysenteriae / Q000187:drug effects*; D012763:Shigella flexneri / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology; D013419:Sulfamethizole / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology; D000096926:Benzenesulfonamides
D000667:Ampicillin; D002701:Chloramphenicol; D004338:Drug Combinations; D013307:Streptomycin; D013419:Sulfamethizole; D013752:Tetracycline; D014295:Trimethoprim; C029078:trimethoprim sulfamethizole; D000096926:Benzenesulfonamides