Physiologic effects of columbinic acid and its metabolites on rat skin.
Columbinic acid and its cyclooxygenase and lipoxygenase metabolites were applied topically to the skin of essential fatty acid-deficient rats and their transepidermal water loss was measured. Despite the ability of the major lipoxygenase metabolite to reverse the scaly dermatitis, neither metabolite of columbinate was able to normalize the epidermal water loss, but the parent acid lowered the measurements in a dose-dependent fashion. These results indicate that some essential fatty acids have important functions as such, and not merely as precursors for other, biologically active, oxygenated metabolites.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005228:Fatty Acids, Essential / Q000172:deficiency; D008042:Linolenic Acids / Q000378:metabolism / Q000494:pharmacology*; D008084:Lipoxygenase / Q000378:metabolism; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects*; D013997:Time Factors
D005228:Fatty Acids, Essential; D008042:Linolenic Acids; C034302:5,9,12-octadecatrienoic acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases