Antimicrobial activities of N-chloramines and diazolidinyl urea.
A combination of MICs of an N-chloramine, a simple chlorinated amino acid, and diazolidinyl urea gave synergistic activity against bacteria, but not fungi. The two compounds at a higher concentration, 0.1 and 0.3%, respectively, gave synergistic inhibition of fungi; kill times were 1 h for Trichophyton tonsurans, 3 h for Aspergillus niger and Fusarium moniliforme, and 6 h for Aspergillus fumigatus.
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002700:Chloramines / Q000494:pharmacology*; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000891:Anti-Infective Agents, Local; D002700:Chloramines; C044983:IRX 1767; C044984:IRX 1775; D014508:Urea; C044982:diazolidinylurea