Synthesis of quinoline-Mannich bases of possible antimalarial activity.
For possible antimalarial activity, a series of some 4-substituted aminoquinoline Mannich bases (5a-e) was synthesized. The antimalarial evaluation showed that compound 5b was active against Plasmodium berghei in mice at a dose of 100 mg/kg.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002739:Chloroquinolinols / Q000138:chemical synthesis* / Q000494:pharmacology; D006912:Hydroxyquinolines / Q000138:chemical synthesis*; D008297:Male; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D010962:Plasmodium berghei / Q000187:drug effects
D000962:Antimalarials; D002739:Chloroquinolinols; D006912:Hydroxyquinolines; D008352:Mannich Bases