Bone marrow transplantation.
Bone marrow transplantation is increasingly used to treat a broad spectrum of human diseases including aplastic anemia, leukemia, solid tumors, immune and genetic disorders. In certain circumstances the role of transplantation is reasonably well established, such as aplastic anemia and resistant leukemia. In other circumstances there is controversey as to the role of transplantation such as leukemia in remission. An increasing number of genetic disorders including severe combined immunodeficiency, Wiskott-Aldrich syndrome, osteopetrosis, and Thalassemia have been cured by transplantation. Despite substantial progress, with transplantation that remain to be solved including graft-vs.-host disease, interstitial pneumonia, immune deficiency, and the lack of suitable donors for most potential recipients. These problems and potential approaches are discussed in detail Future direction of research include the application of transplantation to other diseases as well as the use of this approach either as a prelude to solid-organ grafts or as a vehicle for the introduction of new genetic information.
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D007951:Leukemia, Myeloid / Q000628:therapy; D009369:Neoplasms / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000209:etiology; D012008:Recurrence; D013789:Thalassemia / Q000628:therapy; D014182:Transplantation, Autologous
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II