Effects of anticonvulsant monotherapy in pregnancy on the newborn endocrine system. Preliminary data.
Pituitary-thyroid axis function and gonadotropin secretion were evaluated by a combined TRH and LHRH test in 4 newborn female infants appropriate for gestational age of mothers treated by AEDs throughout pregnancy. We found: high basal FSH levels with normal FSH reserve, normal LH-HCG levels both before and after LHRH stimulation, normal TSH and T4 levels both before and after TRH stimulation, high T3 basal values with a normal increase after TRH and low rT3 basal values. It is suggested an AED increased T4 deiodination towards T3 in the newborn liver without a marked impairment of the endocrine functions of the fetus.
D000927:Anticonvulsants / Q000009:adverse effects*; D004700:Endocrine System Diseases / Q000151:congenital*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000031:analogs & derivatives / Q000097:blood
D000927:Anticonvulsants; D014284:Triiodothyronine; C040407:3,3',5-triiodothyronamine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine