[Immunologic phenotype of blast cells in the diagnosis of myeloblastic leukemias].
A study was made of immunologic cell markers in 32 patients with acute myeloid leukemia by indirect immunofluorescence with the aid of xenogeneic antisera and monoclonal antibodies obtained by the authors. Ia-like antigen demonstrated by monoclonal antisera IKO-I expressed in myeloblastic leukemia with maturation in myelomonoblastic leukemia and in all patients with monoblastic leukemia. Antigen of EK-cells demonstrated by monoclonal antibodies IKO-II was found in 10 out of 18 patients. The number of antigen positive cells correlated with the number of monoblasts. One out of 22 patients showed 19% of cells which express with OLL antigen. In 2 out of 18 cases, the blast cells carried T-cell antigens. A remission was attained in 1 out of these 2 patients treated similarly to patients with OLL.
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006681:HLA-D Antigens; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000276:immunology; D010641:Phenotype; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006681:HLA-D Antigens; D000949:Histocompatibility Antigens Class II
Immunologicheskiĭ fenotip blastnykh kletok v diagnostike ostrykh mieloidnykh leĭkozov.