Serum neuron-specific enolase in metastatic Merkel cell tumors.
Three patients with widely disseminated Merkel cell tumors of the skin are presented. In all three cases, neuron-specific enolase (NSE) was demonstrated in neoplastic tissue by immunohistochemical staining, and serum NSE levels were also elevated in all three patients. Serum NSE may prove to be a useful tumor marker in this and other malignancies of neuroendocrine origin.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000201:enzymology / Q000556:secondary; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011863:Radioimmunoassay; D012878:Skin Neoplasms / Q000201:enzymology* / Q000628:therapy; D013899:Thoracic Neoplasms / Q000201:enzymology / Q000556:secondary
D010751:Phosphopyruvate Hydratase