Calcitonin gene-related peptide projection from the ventromedial thalamic nucleus to the insular cortex: a combined retrograde transport and immunocytochemical study.
We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wheat germ agglutinin (B-WGA) injected into the insular cortex labeled numerous neurons in the vl-vl and the caudal continuation ipsilaterally; simultaneous staining with CGRP antiserum revealed that some of these neurons are CGRP positive.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide; D002540:Cerebral Cortex / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009434:Neural Pathways / Q000378:metabolism; D051381:Rats; D013787:Thalamic Nuclei / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D015740:Calcitonin Gene-Related Peptide