Anti-pseudomonal activity of HR 810.
The anti-pseudomonal activity of HR 810, a new 2-aminothiazolyl cephalosporin, was compared to that of carbenicillin, azlocillin and cefsulodin against 187 non-fermenters. HR 810 was the best agent against Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens and Acinetobacter calcoaceticus with an MIC50 less than or equal to 4 mg/l and an MIC90 less than or equal to 16 mg/l. It was as effective as azlocillin against Pseudomonas stutzeri and Pseudomonas mendocina, with an MIC50 less than or equal to 0.25 mg/l and an MIC90 less than or equal to 1 mg/l. It was not active against other species of Pseudomonas or other non-fermenters such as Flavobacterium sp.
D000150:Acinetobacter / Q000187:drug effects; D000421:Alcaligenes / Q000187:drug effects; D001390:Azlocillin / Q000494:pharmacology; D002228:Carbenicillin / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D005417:Flavobacterium / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011551:Pseudomonas fluorescens / Q000187:drug effects; D000097572:Cefpirome
D001390:Azlocillin; D002228:Carbenicillin; D002511:Cephalosporins; D000097572:Cefpirome