Secondary hypertension and neurofibromatosis: bilateral renal artery stenosis and coarctation of the abdominal aorta.
A 34-year-old white man with generalized neurofibromatosis was found to have severe renal vascular hypertension due to a coarctation of the abdominal aorta and bilateral renal artery stenosis with saccular aneurysms. Increased renal venous renin activity showed the active involvement of the renin-angiotensin system in maintaining the hypertension. Because the patient refused surgical treatment, antihypertensive treatment with Captopril, a specific inhibitor of the angiotensin converting enzyme was used, resulting in normal blood pressure being restored over an 18 month observation period.
D000328:Adult; D000783:Aneurysm / Q000150:complications; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001017:Aortic Coarctation / Q000150:complications*; D001027:Aortography; D002216:Captopril / Q000627:therapeutic use; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D012077:Renal Artery / Q000000981:diagnostic imaging; D012078:Renal Artery Obstruction / Q000150:complications*; D014057:Tomography, X-Ray Computed
D002216:Captopril