Acute nonlymphocytic leukemia with a translocation (1;3)(p36;q21) in an XYY man.
Neoplastic disease is quite rare in an XYY syndrome. We report the fifth known case, who suffered from acute nonlymphocytic leukemia (ANLL). Cytogenetic study of his bone marrow revealed a new chromosomal translocation (1;3)(q36;q21), which has only recently been described in patients with myelodysplastic syndrome.
D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014178:Translocation, Genetic; D014997:XYY Karyotype / Q000235:genetics*