Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.
The effect of in vivo administration of monoclonal anti-L3T4 antibody on the development of murine collagen-induced arthritis (CIA) was assessed. Treatment with anti-L3T4 resulted in a greater than 90% depletion of L3T4+ T cells in lymph nodes and spleen, an effect that appears entirely reversed 30 d after treatment. Administration of anti-L3T4 before immunization with type II collagen resulted in a significant decrease in arthritis incidence and delayed onset of the disease while treatment begun after a strong anticollagen IgG humoral response was underway was not effective in altering disease expression. These results suggest a prominent role for L3T4+ T cells in the pathogenesis of CIA.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000276:immunology*; D001168:Arthritis / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control*; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D003094:Collagen / Q000276:immunology / Q000633:toxicity; D006183:H-2 Antigens / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA / Q000276:immunology
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D001323:Autoantibodies; D006183:H-2 Antigens; D007074:Immunoglobulin G; D003094:Collagen