title: Growth and plasticity of rat cerebral cortex after central noradrenaline depletion.
abstract: Male Wistar rats (aged 31 to 33 days) received bilateral intraventricular injections of saline or 6-hydroxydopamine and were subjected to either "standard" or "enriched" rearing conditions for 42 days. The treatment reduced cerebral cortical noradrenaline by 80% and decreased the growth of the cerebral cortex. It did not, however, prevent experience in an enriched environment from enhancing the growth of the cerebral cortex.
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D004777:Environment; D006892:Hydroxydopamines; D008297:Male; D009473:Neuronal Plasticity; D009638:Norepinephrine / Q000172:deficiency* / Q000378:metabolism; D009929:Organ Size; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine