Effect of topical acyclovir therapy on experimental herpes simplex keratouveitis.
Stromal keratitis and associated iritis were produced in rabbit eyes with the intrastromal injection of live herpes simplex virus. Treatment with 3% acyclovir and 2% trifluridine eye ointments was initiated one day after infection and continued for five consecutive days. These therapies significantly suppressed the development of keratouveitis compared with a placebo ointment. The suppressive action of trifluridine ointment on keratouveitis was significantly more pronounced than that of acyclovir ointment.
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000287:Administration, Topical; D000818:Animals; D007500:Iritis / Q000188:drug therapy; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009824:Ointments; D011817:Rabbits; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000008:administration & dosage / Q000627:therapeutic use*; D014605:Uveitis / Q000188:drug therapy*
D009824:Ointments; D014271:Trifluridine; D013936:Thymidine; D000212:Acyclovir