title: Thin-section CT of midbrain abnormalities in progressive supranuclear palsy.
abstract: Thin-section computed tomographic (CT) scans of 3 and 1.5 mm thickness were obtained using the Philips Tomoscan 310 and General Electric 8800 CT/T scanners in the study of 10 consecutive patients with progressive supranuclear palsy (PSP) and 31 patients with other diseases. Marked midbrain and moderate pontine atrophy, a dilated third ventricle, and enlarged quadrigeminal plate cisterns were observed in all PSP cases. The aqueduct was dilated in several. In six of the PSP cases, there was a striking midbrain abnormality in the form of a low-density area extending from the interpeduncular cistern toward the aqueduct. Thin-section metrizamide-enhanced cisternography of three of the six PSP cases showed that the low-density abnormality was the result of the interpeduncular cistern invaginating the atrophic midbrain.
mesh_terms: D000368:Aged; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D010243:Paralysis / Q000000981:diagnostic imaging*; D011149:Pons / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed