[The effects of different inhibitors on the bronchoconstriction induced by leukotriene D4 in the isolated and perfused guinea pig lung].
The effects of selective inhibitors of both cyclo-oxygenase and lipoxygenase pathways were studied in the isolated, perfused and ventilated guinea-pig lungs. Leukotriene D4 (0,3 nmol) induced a significant bronchoconstriction. This effect was significantly inhibited by FPL 55712 (a SRS-A antagonist) and by Imidazole or Dazoxiben (specific thromboxane synthetase inhibitors), but aspirin and indomethacin were without significant effect on this bronchoconstriction. Our results suggests that the principal component of leukotriene D4 induced bronchoconstriction in guinea-pig lungs is primary.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008084:Lipoxygenase / Q000378:metabolism; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology*
D001993:Bronchodilator Agents; D013189:SRS-A; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases
Effets de différents inhibiteurs sur la bronchoconstriction induite par le leucotriène D4 au niveau du poumon isolé et perfusé de cobaye.