title: Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster.
abstract: To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000633:toxicity; D004331:Drosophila melanogaster / Q000187:drug effects*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009152:Mutagenicity Tests; D011796:Quinacrine / Q000494:pharmacology* / Q000633:toxicity; D012729:Sex Chromosome Aberrations / Q000139:chemically induced
chemical_list: D002738:Chloroquine; D011796:Quinacrine