Chloroquine reduces neuronal and glial iron uptake.
The effect of chloroquine, a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported. Chloroquine significantly inhibited iron uptake in both neuronal and glial cells. These findings suggest that iron transport into both neuronal and glial cells is mediated by the transferrin-iron complex.
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D002738:Chloroquine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007501:Iron / Q000378:metabolism*; D051379:Mice; D009457:Neuroglia / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism
D002738:Chloroquine; D007501:Iron