title: Catheter-associated bacteriuria. An experimental study.
abstract: A bacteriologically-stressed catheterized animal model was developed to evaluate the comparative importance of the intraluminal versus the extraluminal route of catheter-acquired urinary tract infections. This study indicated that in short-term catheterization (less than 7 days), contamination of the drainage spout or accidental disconnection of the drainage tube resulted in bacteriuria within a short time (32-48 hours). If a strict sterile closed drainage system was maintained, the extraluminal route assumed more importance in the development of bacteriuria, however this pathway was considerably slower (72-168 hours). It appeared that catheter-associated bacteriuria results from ascending bacterial colonization within glycocalyx-enclosed biofilm on the inside and/or outside surfaces of the catheter and drainage systems. Development of a biomaterial that inhibits bacterial adherence and does not allow upstream colonization of bacteria on the catheter drainage system would significantly influence the rate of catheter-acquired urinary tract infection.
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001437:Bacteriuria / Q000209:etiology* / Q000382:microbiology; D003428:Cross Infection / Q000209:etiology*; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000502:physiology / Q000648:ultrastructure; D011817:Rabbits; D013997:Time Factors; D014546:Urinary Catheterization / Q000009:adverse effects* / Q000379:methods