Complete tyrosine O-sulfation of gastrin in adult and neonatal cat pancreas.
We have found gastrin in both the adult and neonatal cat pancreas. In contrast with the main production sites, antrum and duodenum, gastrin in the pancreas occurs in a single molecular form, tyrosine O-sulfated gastrin-17. Since tyrosine sulfation increases the pancreozymic effect of gastrin, the complete sulfation seems functionally expedient.
D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D004285:Dogs; D005755:Gastrins / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
D005755:Gastrins; C005662:tyrosine O-sulfate; D014443:Tyrosine