Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline alpha-mannosidosis.
Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced alpha-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.
D000470:Alkaloids; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000254:growth & development* / Q000473:pathology; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D017026:Swainsonine; D008363:alpha-Mannosidosis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D000470:Alkaloids; D017026:Swainsonine