Interactions between hepatotropic viruses in patients with haemophilia.
Infections with the hepatotropic viruses non-A, non-B (NANB), hepatitis B (HBV) and delta agent (HDV) are described in two patients with haemophilia. The first patient illustrates the phenomenon of interference following a simultaneous exposure to NANB and HBV. The second patient, a carrier of hepatitis B surface antigen (HBsAg), acquired superinfection with HDV which resulted in acute hepatitis progressing to chronic hepatitis. Liver disease seen in multitransfused haemophiliacs may be significantly different to that seen in other patients. As a consequence of the infusion of blood clotting factor concentrates, these patients become the site of complex viral interactions.
D002648:Child; D005164:Factor IX / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006509:Hepatitis B / Q000150:complications* / Q000209:etiology / Q000382:microbiology; D006515:Hepatitis B virus / Q000502:physiology; D006526:Hepatitis C / Q000150:complications* / Q000209:etiology / Q000382:microbiology; D003699:Hepatitis D / Q000150:complications* / Q000209:etiology / Q000382:microbiology; D003698:Hepatitis Delta Virus / Q000502:physiology; D006518:Hepatitis Viruses / Q000502:physiology*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction; D014779:Virus Replication
D005169:Factor VIII; D005164:Factor IX