Central cholinergic-dopaminergic interaction in carbaryl-induced tremor.
Acute administration of the anticholinesterase agent carbaryl to rats produced a dose-dependent increase of tremors. The carbaryl-induced tremor was significantly reduced by prior treatment of the rats with either atropine or L-DOPA and was exacerbated by haloperidol. These results suggest the possible involvement of a central cholinergic-dopaminergic interaction in the carbaryl-induced tremor.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D012721:Carbaryl / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002230:Carbidopa / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006220:Haloperidol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D014202:Tremor / Q000139:chemically induced* / Q000378:metabolism
D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D007980:Levodopa; D001285:Atropine; D006220:Haloperidol; D002230:Carbidopa; D012721:Carbaryl