A variant myelodysplastic syndrome with multilineage Pelgeroid chromatin.
An unusual myelodysplastic syndrome with similar features in two patients is described. The entity is characterized by a maturation arrest at the myelocyte stage, strikingly clumpy chromatin, and a clinical course marked primarily by difficulties caused by anemia and thrombocytopenia. Electron microscopic description of the characteristic abnormal clumpy chromatin cells is included. While the disorder is unquestionably a myelodysplastic syndrome, it is clearly distinct from chronic myelogenous leukemia, chronic myelomonocytic leukemia, and the spectrum of refractory anemias with excess blasts.
D000368:Aged; D002843:Chromatin / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D010381:Pelger-Huet Anomaly / Q000473:pathology*; D011289:Preleukemia / Q000473:pathology*
D002843:Chromatin