Isolation and identification of alpha-(gamma-aminobutyryl)-hypusine.
A new dipeptide, alpha-(gamma-aminobutyryl)-hypusine, was identified in bovine brain. This compound was isolated from trichloroacetic acid-soluble fraction of bovine brain with five steps of ion-exchange chromatography. Its structure was postulated by routine chemical analyses and determined by synthesis. The amount of the compound isolated from 1.2 kg of bovine brain was 870 nmol.
D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004151:Dipeptides / Q000302:isolation & purification*; D004590:Electrophoresis, Paper
D004151:Dipeptides; C048217:alpha-(4-aminobutyryl)hypusine