title: Schilder's (1912) disease. Total cerebral blindness due to acute demyelination.
abstract: A 51-year-old woman became blind from involvement of both occipital lobes with a confluent lesion demonstrated by computed tomographic scan. Biopsy showed demyelination consistent with Schilder's 1912 variant of diffuse sclerosis. No cytoplasmic inclusions were found on electron microscopy.
mesh_terms: D000208:Acute Disease; D001766:Blindness / Q000209:etiology*; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D003711:Demyelinating Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009186:Myelin Sheath / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed