Shock following generalized hypoxic-ischemic injury in previously healthy infants and children.
Eighteen previously healthy patients with hypoxic-ischemic shock were observed longitudinally by means of data measured or derived from systemic arterial and pulmonary artery catheters. Shock was characterized by low cardiac index, elevated right and left heart filling pressures, elevated systemic and pulmonary vascular resistances, decreased oxygen consumption, and elevated oxygen extraction indices. Oxygen consumption was significantly correlated with oxygen delivery (r = 0.74, P less than 0.0001). This pattern fits that of cardiogenic shock. Cardiopulmonary data were not significantly different in survivors (n = 10) and nonsurvivors (n = 8). Outcome was determined by neurologic injury.
D001794:Blood Pressure; D002302:Cardiac Output; D002404:Catheterization; D002648:Child; D002675:Child, Preschool; D004332:Drowning; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D007223:Infant; D007511:Ischemia / Q000150:complications*; D008168:Lung / Q000098:blood supply; D009422:Nervous System Diseases / Q000209:etiology; D010101:Oxygen Consumption; D010102:Oxygen Inhalation Therapy; D011446:Prospective Studies; D012129:Respiratory Function Tests; D012151:Resuscitation; D012770:Shock, Cardiogenic / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D013398:Sudden Infant Death; D014655:Vascular Resistance