[Modification of 3-methylcholanthrene-induced blastomogenesis in BALB/c mice by using the subcellular components of Bac. megaterium H].
It is shown that the cytoplasm of Bac. megaterium H possessing the antigenic affinity with the malignant tumour cells, being injected 7 days before the 3-methylcholanthrene injection promotes intensification of its blastomogenic effect, reduces both the period of tumour appearance and longevity of the tumour-bearing animals. On the contrary the cell wall preparation under the similar conditions, produces a therapeutic effect. An assumption is advanced that the effect of these preparations is associated with their different influence on the immune system.
D000818:Animals; D001410:Bacillus megaterium / Q000276:immunology*; D002473:Cell Wall / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D007114:Immunization / Q000379:methods; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology / Q000401:mortality; D013997:Time Factors
D008748:Methylcholanthrene
Modifikatsiia blastomogeneza, indutsirovannogo 3-metilkholantrenom u mysheĭ BALB/c, pri pomoshchi subkletochnykh komponentov Bac. megaterium H.