Enhancing effects of Hoe 175 on memory in mice.
These experiments investigated the effects of the nootropic compound Hoe 175 [3,8-dimethyl-4-phenyl-5,6,7,8-tetrahydro-pyrazolo-(3,4-b) (1,5)-diazepine-1H,4H-5,7-dione] on retention performance of mice in three training tasks. When administered prior to both training and retention testing on a one-trial inhibitory avoidance task, Hoe 175 (6-25 mg/kg PO) attenuated the amnestic effect of transcorneal electroconvulsive shock. Post-training administration of Hoe 175 enhanced retention of otherwise untreated mice in both inhibitory (3-12 mg/kg IP) and active avoidance (1-25 mg/kg IP) learning tasks. The drug was most effective at intermediate doses. The enhancing effect of post-training administration of Hoe 175 was time-dependent: enhancement of retention was obtained with injections administered 2 h but not 6 h after training. The findings are interpreted as suggesting that Hoe 175 affects retention performance through influences on memory storage and retrieval.
D000647:Amnesia / Q000517:prevention & control; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001381:Azepines / Q000494:pharmacology* / Q000627:therapeutic use; D004597:Electroshock; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D012153:Retention, Psychology / Q000187:drug effects; D013268:Stimulation, Chemical
D001381:Azepines; C046302:HOE 175