Valproate-induced hyperammonaemia in two epileptic identical twins.
The cases of two epileptic identical twins are described, one of whom had presented an episode of valproate (VPA)-induced stupor associated with very high blood ammonia (NH3) concentrations. Both twins showed a similar marked increase of venous NH3 concentrations after the administration of a single loading dose of VPA (800 mg).
D000328:Adult; D000641:Ammonia / Q000097:blood*; D004200:Diseases in Twins; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000188:drug therapy / Q000235:genetics*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid; D000641:Ammonia