title: Modification of the nucleolar structure of the rat oocyte observed just before maturation.
abstract: Oocytes removed from antral follicles of 28- to 30-day-old rats treated with FSH (Folligon) show cavities and vesicles in the nucleoli. Repeated injections of Folligon significantly increase the frequency of these nucleolar inclusions. A possible relationship between intranucleolar cavities and rRNA metabolism has been suggested to account for this occurrence.
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D051381:Rats
chemical_list: D005640:Follicle Stimulating Hormone