Malignant melanoma of the choroid in a mother and retinoblastoma in her son.
A 31-year-old woman was diagnosed as having a malignant melanoma of the choroid in the right eye. Twenty months later her 7-year-old son was diagnosed as having retinoblastoma in the right eye. Both diagnoses were confirmed histopathologically after enucleation. A chromosomal study revealed normal karyotypes in the son. The family history was positive for cancer of the stomach. The implications of this rare association are discussed.
D000328:Adult; D002648:Child; D002830:Choroid Neoplasms / Q000235:genetics* / Q000473:pathology; D003241:Consanguinity; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D012175:Retinoblastoma / Q000235:genetics* / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics