[Mitigation of cisplatin toxicity by the complexon tetacin-calcium].
A possibility to decrease toxic properties of intraperitoneally injected platidiam (cis-platin, CSSR) administered by means of edtacal, a complexon (tetracinium-calcium, CSSR), administered per os is studied. It is established in intact mice that administration of edtacal simultaneously with platidiam or 1 h before decreases the mortality rate, diarrhea incidence and animal body mass loss. Edtacal is shown to have also an antiemetic action. Edtacal administered simultaneously with platidiam as well as 1 and 3 h before its injection does not decrease the antitumour activity of the preparation in (C57B1 X CBA)F1 mice with the Ehrlich ascite carcinoma.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D000932:Antiemetics / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002945:Cisplatin / Q000627:therapeutic use / Q000633:toxicity*; D004285:Dogs; D004492:Edetic Acid / Q000627:therapeutic use*; D051379:Mice
D000931:Antidotes; D000932:Antiemetics; D004492:Edetic Acid; D002945:Cisplatin
Umen'shenie toksicheskogo éffekta tsisplatina pod vliianiem kompleksona tetatsin-kal'tsiia.