Mutagenic evaluation of propranolol in somatic and germ cells of mice.
The mutagenic effect of an antihypertensive drug, propranolol, was studied on somatic and germ cells of Swiss albino mice. The induction of a significant increase in the frequency of micronuclei in erythrocytes was observed at higher dose levels, whereas, in germ cells, propranolol failed to induce significant chromosomal aberrations at any dose tested.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004913:Erythrocytes, Abnormal / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D011433:Propranolol / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects / Q000648:ultrastructure
D011433:Propranolol