Modification of nucleic acids with 1-nitropyrene in the rat: identification of the modified nucleic acid base.
A modified nucleic acid base was isolated from liver DNA of rats treated with 1-nitropyrene. The structure of the modified nucleic acid base was identified as 1-(guanin-8-yl)-aminopyrene by comparison with an authentic sample.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011721:Pyrenes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011721:Pyrenes; D004247:DNA; C032668:1-nitropyrene