title: Mutation of Pseudomonas aeruginosa to piperacillin resistance mediated by beta-lactamase production.
abstract: Piperacillin-resistant mutants were detected in each of ten strains of Pseudomonas aeruginosa. The resistance was associated with constitutive production by the strains of high levels of beta-lactamase which was similar in character to the induced chromosomal Id beta-lactamase of the parent strains. This type of mutation to piperacillin-resistance occurred at a low frequency. The beta-lactamase production and piperacillin-resistance were stable on repeated subculture and prolonged storage of the strains.
mesh_terms: D009154:Mutation; D010403:Penicillin Resistance; D010878:Piperacillin / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001618:beta-Lactamases; D010878:Piperacillin