Serum-mediated oligodendrocyte cytotoxicity in multiple sclerosis patients and controls.
We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding a source of complement. Despite apparent lack of disease specificity, such factors might damage oligodendrocytes if they gained access to these cells through a damaged blood-brain barrier in MS or other disorders.
D000328:Adult; D000818:Animals; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D006168:Guinea Pigs; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology*; D009836:Oligodendroglia / Q000276:immunology*; D011817:Rabbits; D051381:Rats
D003165:Complement System Proteins