Polychlorinated biphenyl poisoning: correlation of sensory and motor nerve conduction, neurologic symptoms, and blood levels of polychlorinated biphenyls, quaterphenyls, and dibenzofurans.
In 1979 in Taiwan, more than 2000 people were poisoned with rice cooking oil contaminated with polychlorinated biphenyls (PCB). One hundred ten patients were studied within one year of the exposure. The blood PCB levels were 39.3 +/- 16.6 ppb. The blood levels of the PCB derivatives, polychlorinated quaterphenyls (PCQ) and polychlorinated dibenzofurans (PCDF), were 8.6 +/- 4.8 and 0.076 +/- 0.038 ppb, respectively. Both the sensory and motor nerve conduction velocities (NCV) of the patients were significantly lower than the control. Abnormal slowing of sensory NCV was found in 43.6% and abnormal slowing of motor NCV was seen in 21.8%. Patients who had higher PCQ blood levels had significantly slower median nerve sensory NCV than those with lower PCQ levels. Patients with higher PCB blood levels had significantly slower peroneal nerve motor NCV than those with lower PCB levels.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000187:drug effects; D008875:Middle Aged; D009431:Neural Conduction / Q000187:drug effects*; D010292:Paresthesia / Q000139:chemically induced / Q000175:diagnosis; D010543:Peroneal Nerve / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D013979:Tibial Nerve / Q000187:drug effects; D014459:Ulnar Nerve / Q000187:drug effects
D011078:Polychlorinated Biphenyls