Population genetic and family studies on aldehyde dehydrogenase deficiency and alcohol sensitivity.
Population genetic studies on the prevalence of aldehyde dehydrogenase isozyme I (ALDH I) deficiency in various Caucasian, Oriental, African, and American Indian subjects were carried out using hair roots as peripheral source of the enzyme activity. While a very high percentage of Orientals with Mongoloid origin were found deficient in ALDH I activity, no deficiency was detected in Caucasian and African populations. Native American Indians showed a relatively low incidence of ALDH I deficiency. A genetic model based on the phenotype determination using antisera against purified human liver ALDH I is proposed. Pedigree analysis of Japanese families suggests an autosomal codominant mode of inheritance.
D000444:Aldehyde Dehydrogenase / Q000172:deficiency / Q000235:genetics*; D004361:Drug Tolerance; D004587:Electrophoresis, Agar Gel; D000431:Ethanol; D005260:Female; D005828:Genetics, Population; D006197:Hair / Q000201:enzymology; D006801:Humans; D005779:Immunodiffusion; D007123:Immunoelectrophoresis, Two-Dimensional; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000172:deficiency* / Q000235:genetics; D008297:Male; D010375:Pedigree; D010641:Phenotype
D007527:Isoenzymes; D000431:Ethanol; D000444:Aldehyde Dehydrogenase