Target cells for dihydrotestosterone in the guinea pig pituitary gland.
Adult male guinea pigs were castrated and 24 h later injected with [3H]dihydrotestosterone. Their pituitary glands were then processed for autoradiographic and immunocytochemical analyses. Three percent of the parenchymal cells in the pars distalis were radiolabelled. These cells were primarily gonadotrophs; a small population of thyrotrophs were also found to retain the [3H]androgen. Labelling occurred in cells of the pars intermedia (3.2%) as well as in 9.6% of the pituicytes. These data indicate that in addition to gonadotrophs, the pars nervosa is a major target for dihydrotestosterone in the guinea pig pituitary gland.
D000818:Animals; D001345:Autoradiography; D013196:Dihydrotestosterone / Q000378:metabolism*; D006168:Guinea Pigs / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism; D014018:Tissue Distribution; D014316:Tritium
D013196:Dihydrotestosterone; D014316:Tritium; D007986:Luteinizing Hormone; D013972:Thyrotropin