title: Ultrastructure of skin window cells in malignant lymphoma.
abstract: The ultrastructure of cells in skin window preparations was analysed in 38 patients with malignant lymphoma and in 22 normal subjects. In the series as a whole, there were significant morphological changes in the macrophages between day 1 and day 2 consistent with cell maturation during the inflammatory response. At both intervals, lymphoma patients showed strikingly larger cell and nuclear profile areas as compared with normal subjects; there was a greater number of nucleoli per profile and proportionately more sections showed a Golgi complex. At day 1, a greater percentage of the patients' macrophages showed large numbers of phagocytic inclusions, but at day 2, significantly fewer profiles demonstrated this feature. These morphological findings could be a reflection of the known mononuclear phagocyte dysfunction in malignant lymphoma.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000648:ultrastructure*; D008264:Macrophages / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000473:pathology / Q000648:ultrastructure*; D012884:Skin Window Technique