[Dupuytren contracture in childhood].
A two-year old boy suffered a contracture of the second and third digit beginning at the age of seven months. The clinical examination suggested a diagnosis of early Dupuytren's disease. A partial fasciectomy was performed. Histological examination showed a fibrosis palmaris similar to Dupuytren's disease. The biochemical examination (Glycans, hyaluronic acid, chrondroitinsulfat, dermatansulfat and heparansulfat) showed also changes in the extracellular proteoglycanmatrix similar to those found in adult Dupuytren's disease.
D002675:Child, Preschool; D002809:Chondroitin Sulfates / Q000378:metabolism; D003871:Dermatan Sulfate / Q000378:metabolism; D004387:Dupuytren Contracture / Q000473:pathology / Q000601:surgery*; D005205:Fascia / Q000473:pathology; D006025:Glycosaminoglycans / Q000378:metabolism; D006225:Hand / Q000473:pathology / Q000601:surgery; D006227:Hand Deformities, Acquired / Q000473:pathology / Q000601:surgery*; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D008297:Male; D013710:Tendons / Q000473:pathology
D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D006820:Hyaluronic Acid
Dupuytren'sche Kontrakturen im Kindesalter.