Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells.
Histamine inhibited the production of interferon-gamma and interleukin 2 (IL-2) induced in human peripheral blood mononuclear cells by Staphylococcal Enterotoxin A (SEA) but had no effect on the expression of IL-2 receptors. The effects on lymphokine production were dose dependent with maximal inhibition occurring at histamine concentrations of 10(-4) to 10(-6) M. The H2-agonist 4-methylhistamine but not the H1-agonist 2-methylhistamine modulated lymphokine production in a similar manner as histamine. Histamine at concentrations of 10(-3) to 10(-8) M had no inhibitory effect directly on the activity of admixed IL-2 containing medium. The inhibitory effects of histamine could be reversed by the H2-antagonist cimetidine but not by the H1-antagonist diphenhydramine. This indicates that the inhibitory effects of histamine on lymphokine production are mediated through H2-receptors on mononuclear cells.
D004306:Dose-Response Relationship, Immunologic; D004768:Enterotoxins / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000187:drug effects; D011971:Receptors, Immunologic / Q000187:drug effects; D015375:Receptors, Interleukin-2
D004768:Enterotoxins; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D011970:Receptors, Histamine H2; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; C026066:enterotoxin A, Staphylococcal; D006632:Histamine; D007371:Interferon-gamma