Activation of c-Ki-ras gene in human pancreatic cancer.
DNA isolated from a lymph node with metastasis from pancreatic adenocarcinoma in a Japanese male patient transformed NIH3T3 cells upon transfection by the calcium-phosphate precipitation technique. Analysis of DNA from the transformant revealed the presence of an activated human c-Ki-ras gene, which is considered to be responsible for the transformation of the NIH3T3 cells.
D000230:Adenocarcinoma / Q000235:genetics*; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000235:genetics*; D014162:Transfection
D004273:DNA, Neoplasm