Selective phosphorylation of human DNA methyltransferase by protein kinase C.
Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.
D002118:Calcium / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D010743:Phospholipids / Q000494:pharmacology; D010766:Phosphorylation; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D013379:Substrate Specificity
D010743:Phospholipids; D004247:DNA; D004248:DNA (Cytosine-5-)-Methyltransferases; D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium