Linkage of the alpha G Philadelphia locus to alpha-thalassemia in the Cuban population.
The inheritance of the alpha-chain hemoglobin variant G Philadelphia was studied in three Cuban families of African ancestry. The variant represented approximately 33% of the total adult hemoglobin in all subjects, and was associated to a 10.5 kb Bam HI restriction fragment. Mild hematological alterations were present. These data indicate that also in the Cuban population the alpha G Philadelphia locus is linked to a deletional alpha-thalassemia.
D000328:Adult; D044383:Black People; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D003462:Cuba; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D013789:Thalassemia / Q000235:genetics*
D006455:Hemoglobins, Abnormal; C031679:hemoglobin G Philadelphia