Selective inhibition by fenflumizole tissue cyclooxygenase in rabbits ex vivo.
A new non-steroidal anti-inflammatory drug fenflumizole when administered orally to rabbits at therapeutic doses of 10 and 30 mg/kg affects neither PGI2 generation by arterial slices nor PGE2 generation by gastric mucosa, respectively. Fenflumizole at doses of 10 and 30 mg/kg per os inhibits platelet aggregability and generation of TXA2 by platelets. It is suggested that this selective action of fenflumizole on tissue cyclooxygenase ex vivo may justify with fenflumizole in anti-thrombotic therapy.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D015232:Dinoprostone; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011458:Prostaglandins E / Q000096:biosynthesis; D011817:Rabbits; D013928:Thromboxane A2 / Q000096:biosynthesis
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; D011458:Prostaglandins E; D013928:Thromboxane A2; D011464:Epoprostenol; D015232:Dinoprostone; C038996:fenflumizole