Plasma protease inhibitor and anaphylatoxin inactivator levels in chronic urticaria/angioedema and in patients experiencing anaphylactoid reactions to radiographic contrast media.
Since a protease inhibitor or anaphylatoxin inactivator deficiency might explain why certain individuals are prone to develop chronic urticaria/angioedema or anaphylactoid reactions to radiographic contrast media, serum alpha 1-protease inhibitor, alpha 1-antichymotrypsin, alpha 2-macroglobulin, inter-alpha-inhibitor, antithrombin III, alpha 2-plasmin inhibitor, C1 inhibitor, and serum carboxypeptidase N were assessed by immunologic or functional methods. These values all were within normal limits in both groups of patients except for a low mean alpha 1-protease inhibitor level in chronic idiopathic urticaria/angioedema and cold urticaria patients and marginal decreases of alpha 1-protease and inter-alpha-inhibitor levels in radiographic contrast medium reactors. However, these abnormalities were not thought to be of pathogenetic significance.
D000706:Anaphylatoxins / Q000037:antagonists & inhibitors*; D000707:Anaphylaxis / Q000139:chemically induced*; D000799:Angioedema / Q000097:blood*; D002908:Chronic Disease; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D009391:Nephelometry and Turbidimetry; D010455:Peptides / Q000037:antagonists & inhibitors*; D011480:Protease Inhibitors / Q000097:blood*; D014581:Urticaria / Q000097:blood*
D000706:Anaphylatoxins; D003287:Contrast Media; D010455:Peptides; D011480:Protease Inhibitors