Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin.
Sodium valproate (VPA) inhibited the mitotic index of neuroblastoma (Neuro-2A) and glioma (C6) cells with an IC50 of 0.5 and 1.0 mM, respectively. Continued exposure of these cell lines to 1 mM VPA induced differentiation and increased adhesiveness. These observations are characteristic of putative teratogens and this implication for VPA is discussed.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005910:Glioma / Q000188:drug therapy / Q000473:pathology*; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects*; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014635:Valproic Acid / Q000633:toxicity*
D014635:Valproic Acid; D013936:Thymidine