A possible new type of chromosome rearrangement: telomere-centromere translocation (tct) followed by double duplication.
The reassessment of a case of complex interchromosomal rearrangement after breakage at centromeric and telomeric regions, and the comparison with four other independently published cases suggested the existence of a new type of rearrangement. It would consist of: formation of an isochromosome after breakage at a centromeric region, duplication of the telomeric region of another chromosome, and reassociation of the nonduplicated arm of the first chromosome with the duplicated telomeric region of the second chromosome.
D002503:Centromere; D002871:Chromosome Banding; D002875:Chromosomes; D002900:Chromosomes, Human, 1-3; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007621:Karyotyping; D014178:Translocation, Genetic