[Detection of cells resistant to the cytotoxic action of CCl4 in the hepatocyte populations of rats following a single exposure to 4-dimethylaminoazobenzene combined with subsequent injections of the tumor promoter phenobarbital].
It is found that hepatic cells of intact rats measuring 129-192 mcm2 are resistant to cytotoxical action of carbon tetrachloride (CCl4). After a single interperitoneal injection of the carcinogen 4-dimethylaminoazobenzene, small hepatocytes (64-128 mcm2) appear to be maintained for one month following five injections of phenobarbital. These small hepatocytes are resistant to cytotoxical action of CCl4. The resistance was studied using a cytochemical test on succinate dehydrogenase. A direct dependence exists between the cell size and the sensitivity to CCl4 among large sized hepatocytes.
D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors*; D002273:Carcinogens; D002469:Cell Separation; D004351:Drug Resistance; D006651:Histocytochemistry; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010634:Phenobarbital / Q000633:toxicity*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors; D004124:p-Dimethylaminoazobenzene / Q000633:toxicity*
D002273:Carcinogens; D004124:p-Dimethylaminoazobenzene; D002251:Carbon Tetrachloride; D013385:Succinate Dehydrogenase; D010634:Phenobarbital
Vyiavlenie rezistentnykh k tsitotoksicheskomu deĭstviiu CCl4 kletok v populiatsiiakh gepatotsitov krys posle odnokratnogo vozdeĭstviia 4-dimetilaminoazobenzolom v sochetanii s posleduiushchimi in''ektsiiami opukholevogo promotora fenobarbitala.