Evolution and expression of the transplantation antigen gene family.
We have cloned 26 different class I genes that are located in the major histocompatibility complex of the C57BL/10 mouse. Two of the three class I genes found in the H-2 complex encode the H-2Kb and H-2Db antigens; the other 23 class I genes map to the adjacent Tla complex. We have grouped the cosmids containing these genes into three clusters: one cluster links the H-2K and I-A regions, one cluster links the H-2D and Qa-2 regions, and the final cluster maps to the TL region. The class I gene organizations in the Qa-2 and TL regions of the C57BL/10 and BALB/c mice are generally similar, but there are several polymorphic segments. The Qa-2 region of both mice seems to have evolved by the duplication of gene pairs; furthermore, the H-2K region may have been generated by the translocation of a gene pair from the Qa-2 region. We have evidence that several of the genes in the Qa-2 region are expressed.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D005796:Genes; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006649:Histocompatibility Antigens / Q000145:classification / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D000954:Antigens, Surface; D006183:H-2 Antigens; C024755:H-2K(K) antigen; D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; C040588:Tla antigens