title: Mania induced by tricyclic-MAOI combination therapy in bipolar treatment-resistant disorder: case reports.
abstract: Three patients with bipolar disorder developed manic symptoms while receiving a combination of isocarboxazid and amitriptyline during an episode of major depression refractory to previous treatments. It is suggested that mania be considered a possible complication of combined treatment with an MAO inhibitor and a tricyclic antidepressant.
mesh_terms: D000639:Amitriptyline / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D000639:Amitriptyline; D007520:Isocarboxazid