Pharmacokinetics of amikacin in pony foals after a single intramuscular injection.
Six healthy pony foals, from 2 to 11 days of age, were given a single IM injection of amikacin sulfate (250 mg/ml) at a dosage rate of 7 mg/kg of body weight. Serum amikacin concentrations were measured serially over a 24-hour period. The mean peak serum concentration was 14.7 micrograms/ml at 0.5 hour. The elimination rate constant for amikacin was 0.24/hour, the elimination half-life was 3.0 hours, and the apparent volume of distribution was 0.58 L/kg.
D000583:Amikacin / Q000008:administration & dosage / Q000097:blood*; D000818:Animals; D000831:Animals, Newborn; D006207:Half-Life; D006736:Horses / Q000097:blood*; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000031:analogs & derivatives*; D007700:Kinetics; D008657:Metabolic Clearance Rate
D007612:Kanamycin; D000583:Amikacin