Inheritance of atrioventricular conduction time in Tokelau Islanders.
The inheritance of A-V conduction time in Polynesians has been examined, using ECGs taken from the population of the Tokelau Islands. As has been demonstrated in other racial groups, A-V conduction time was influenced by sex, age, and heart rate. Complex segregation analysis provides evidence for a significant polygenic influence on A-V conduction, but no evidence for a major gene. Familial correlations and commingling analysis are in agreement with this conclusion. The heritability of A-V conduction time was 0.46. The hypothesis of Møller & Heiberg (1980a) that a major gene could be influencing A-V conduction, is not supported by these data.
D001283:Atrioventricular Node / Q000502:physiology*; D005260:Female; D005826:Genetics, Medical; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008297:Male; D009520:New Zealand; D012044:Regression Analysis; D013997:Time Factors