[Effect of phytoecdysteroids and steranobols on the activity and stability of membrane-bound enzymes of liver mitochondria in experimental hepatitis].
After administration of phytoecdisteroids (ecdisterone, turkesterone) at a dose of 5 mg/kg and the anabolic steroid preparation nerobol at a dose of 10 mg/kg into rats with experimental hepatitis caused by CCl4 poisoning, positive alterations were found in activity of the polyenzymatic systems in membranes of liver mitochondria simultaneously with an increase in their stability and resistance to the effect of exogenous factors producing the mitochondria degradation (controlled heating, treatment with phospholipase A2 or trypsin). These alterations, which appear to occur due to development of strong binds between phospholipids and proteins of inner mitochondrial membrane, promoted normalization of the respiratory chain and the outer pathway of electron transport in hepatocytes of rats with hepatitis.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000378:metabolism; D002783:Cholestenones / Q000494:pharmacology; D004441:Ecdysterone / Q000031:analogs & derivatives*; D007425:Intracellular Membranes / Q000201:enzymology; D008297:Male; D008696:Methandrostenolone / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000494:pharmacology*; D051381:Rats
D002783:Cholestenones; D009097:Multienzyme Complexes; D010937:Plant Growth Regulators; D004441:Ecdysterone; C017787:turkesterone; D008696:Methandrostenolone
Vliianie fitoékdisteroidov i steranobolov na aktivnost' i stabil'nost' membranno-sviazannykh fermentov mitokhondriĭ pecheni pri éksperimental'nom gepatite.