Hyperglycemic effect of high doses of dobutamine in the rat: studies of insulin and glucagon secretion.
The influence of dobutamine on glucoregulation has been assessed in the rat during and after an intravenous infusion given at the following doses: 0, 0.1, 1.0, 10, 100, and 1000 micrograms X kg-1 X min-1. Plasma glucose, insulin, and glucagon levels were measured at 15-min intervals in unanesthetized previously cannulated rats. Basal glucose levels were preserved with the less than or equal to 10 micrograms X kg-1 X min-1 doses. At the greater than or equal to 100 micrograms X kg-1 X min-1 doses, a marked hyperglycemic effect was observed, partly attributable to some inhibitory effect of dobutamine on glucose-induced insulin secretion and to its stimulatory effect on glucagon secretion. Such data suggest that dobutamine may disturb the normal glucose homeostasis, particularly in situations of deficient insulin reserve.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004280:Dobutamine / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D006943:Hyperglycemia / Q000139:chemically induced*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D008353:Mannitol; D004280:Dobutamine; D005934:Glucagon