title: Amplification of c-yes-1 proto-oncogene in a primary human gastric cancer.
abstract: Abnormalities of cellular oncogenes in 22 cases of human primary gastric cancer were screened by Southern blot analysis using 16 onc probes. Human cellular sequences related to the v-yes oncogene of Y73 avian sarcoma virus (human c-yes-1 gene) were found to be amplified in a primary gastric cancer. The degree of amplification was about 4- to 5-fold. Another v-yes-related cellular gene (human c-yes-2, a pseudogene) was not amplified in this tumor. The normal stomach tissue adjacent to the tumor tissue in the same patient showed no amplification of c-yes-1 gene, suggesting that the amplified c-yes-1 is involved in the onset or the progress of this carcinoma.
mesh_terms: D004587:Electrophoresis, Agar Gel; D005753:Gastric Mucosa / Q000378:metabolism; D005784:Gene Amplification; D006801:Humans; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D013274:Stomach Neoplasms / Q000235:genetics*