[Methods of evaluating the efficacy of combinations of aminoglycosides with penicillins and their value for the possibility of predicting the therapeutic effect in patients].
The efficacy of the combinations of aminoglycosides and penicillin with respect to Pseudomonas, Klebsiella and Escherichia strains was estimated with the methods of two-fold serial dilutions of aminoglycosides and constant concentrations of penicillin and the "chess board" method. Correlation between the synergistic effect and sensitivity of the strains to separate components of the combinations was observed. For prediction of the combination efficacy these methods are not useful, since they are labour-intensive and their results are very variable. In this connection a simple informative test is recommended. With the use of this test it is possible to judge the chemotherapeutic efficacy of antibiotics and their combinations by the value of the serum antibacterial activity (titer) against the infection causative agent. The blood serum titer of at least 1:8 is accompanied by a pronounced effect. The test also indirectly provides information on the sensitivity of isolated pathogens and adequacy of the drug blood levels after administration of the chosen dose.
D000818:Animals; D001390:Azlocillin / Q000494:pharmacology; D002228:Carbenicillin / Q000494:pharmacology; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000494:pharmacology
D004338:Drug Combinations; D005839:Gentamicins; D002228:Carbenicillin; D001390:Azlocillin; D010400:Penicillin G; D012853:Sisomicin
Metody otsenki éffektivnosti kombinatsiĭ aminoglikozidov s penitsillinami i ikh znachenie dlia vozmozhnosti prognozirovaniia lechebnogo éffekta u bol'nogo.