[The effects of the pulsatile administration of naloxone on the secretion of gonadotrophins in a case of hypothalamo-hypophyseal amenorrhea].
12 mg of Naloxone were given using an intravenous pulsatile pump at the rate of 0.4 mg/minute every 8 minutes over a period of 4 hours in a woman of 28 years of age who had secondary amenorrhea of hypothalamic origin. The levels of L.H., F.S.H. and Prolactin were calculated every half hour during and after the perfusion. These was a progressive rise in the amplitude of L.H. peaks but no changes in F.S.H. and Prolactin levels. Intermittent inhibition of endogenous opioids seems to re-establish the pulsatile secretions of the hypothalamo-pituitary axis.
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism*; D006801:Humans; D007027:Hypothalamic Diseases / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000097:blood; D009270:Naloxone / Q000008:administration & dosage* / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood
D006062:Gonadotropins; D009270:Naloxone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Effets de l'administration pulsatile de naloxone sur la sécrétion des gonadotrophines dans un cas d'aménorrhée d'origine hypothalamo-hypophysaire.