Enhancement of respiratory response to carbon dioxide produced by lesioning caudal regions of the nucleus of the tractus solitarius.
Bilateral lesions of the caudal region of the nucleus of the tractus solitarius produced a significant enhancement of the ventilatory response to carbon dioxide in awake rats. The result indicates release of an inhibitory influence normally operating at hindbrain level. Respiration in air or oxygen was not affected while hypoxic responses were depressed insignificantly.
D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*
D002245:Carbon Dioxide