Sinus bradycardia associated with peripheral lipids and total parenteral nutrition.
This case report describes a 23-yr-old woman with Crohn's disease who developed sinus bradycardia 4 hr after initiation of total parenteral nutrition with lipids through a peripheral vein. The bradycardia persisted for 1 wk, with only slight improvement when the lipids were held for two 4-hr periods. The heart rate began to improve when lipids were changed from 10 to 20%, and continued to rise after Synthroid was started. The possible relationships between nutritional and thyroid status, as well as lipids and heart rate are discussed.
D000328:Adult; D001919:Bradycardia / Q000139:chemically induced / Q000209:etiology*; D003424:Crohn Disease / Q000150:complications / Q000628:therapy*; D004655:Emulsions; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D054709:Lecithins; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012450:Safflower Oil; D013024:Soybean Oil; D013960:Thyroid Function Tests
D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D054709:Lecithins; C031435:safflower oil, soybean oil, lecithin emulsion; D013024:Soybean Oil; D012450:Safflower Oil