Successful in vitro fertilization with sperm cells from a man with immune infertility.
In vitro fertilization and embryo transfer was carried out in a couple that has been infertile for 7 years. High titers of antisperm autoantibodies in the husband's serum are (table, see text) believed to be the main cause of their infertility. Prolonged methylprednisolone treatment of the man combined with artificial insemination remained unsuccessful. In two IVF attempts embryos were obtained and replaced using capacitated sperm of the husband. A pregnancy was established in the second IVF cycle, but a spontaneous abortion followed after 6 weeks of amenorrhea.
D000328:Adult; D000371:Agglutination; D000372:Agglutination Tests; D000906:Antibodies / Q000032:analysis; D002996:Clomiphene / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000276:immunology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D011374:Progesterone / Q000097:blood; D013075:Sperm Capacitation; D013081:Sperm Motility; D013094:Spermatozoa / Q000276:immunology* / Q000502:physiology
D000906:Antibodies; D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone