Carcinogenicity in rats of a mutagenic compound, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, from tryptophan pyrolysate.
3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is a mutagenic principle isolated from a tryptophan pyrolysate. When Trp-P-1 was given to male and female F344 rats at concentrations of 0.015% and 0.02%, respectively, in the diet, it induced hepatocellular carcinomas in high incidence within a year. No tumor was found in control rats.
D000818:Animals; D002243:Carbolines / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D013997:Time Factors
D002243:Carbolines; D002273:Carcinogens; D009153:Mutagens; C019132:3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole