A calculation of percutaneous drug absorption--II. Computation results.
The numerical computation data of percutaneous drug absorption are reported in this article. When the concentration of a drug in the uppermost epidermis can be considered unchanged, more than 50, 75, 90, 95 and 99% of the amount saturated at quasi-steady-state are accumulated after the respective time intervals of 0.5, 1, 2, 3 and 4 times the lag-time. After the ointment removal, the drug flux from the skin becomes linear on a semilogarithmic scale and the elimination rate constant is not dependent on the initial condition.
D000042:Absorption; D000287:Administration, Topical; D002196:Capillaries / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009994:Osmolar Concentration; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012867:Skin / Q000098:blood supply / Q000378:metabolism*
D004364:Pharmaceutical Preparations