title: X-ray-induced chromosome aberrations in immediately preovulatory oocytes.
abstract: The effects of relatively small doses of X-rays (up to 100 cGy) to immediately preovulatory mouse oocytes have been examined by screening chromosome aberrations at metaphase I. Dose-related responses for the induction of aberrations were found. These were mainly of the quadratic or power-law types, and therefore similar in nature to the dose-responses described elsewhere for dictyate oocytes. The frequencies of the various categories of structural aberration have been compared to the previously determined rates of radiation-induced non-disjunction in immediately preovulatory oocytes in order to examine the potential involvement of structural chromosome aberrations in radiation-induced non-disjunction.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008540:Meiosis; D051379:Mice; D008809:Mice, Inbred C3H; D009630:Nondisjunction, Genetic / Q000528:radiation effects; D009865:Oocytes / Q000528:radiation effects* / Q000648:ultrastructure