Changes in human platelet 5 HT level after 1 week of chlorimipramine treatment.
In platelets of six volunteers taking chlorimipramine (50 mg/day) for 1 week, 5-HT levels were markedly decreased at the time of treatment withdrawal, and remained significantly reduced after a 1-week washout. Individual levels in five subjects remained affected during a 3-week washout. The previously reported observations of reduced serotonin concentration in platelets from depressed patients may reflect a residual effect of previous antidepressant treatment.
D000328:Adult; D001792:Blood Platelets / Q000032:analysis*; D002997:Clomipramine / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
C012273:desmethylclomipramine; D012701:Serotonin; D002997:Clomipramine