Effect of lignocaine and nitrous oxide on hypoxic pulmonary vasoconstriction in the dog constant-flow perfused left lower lobe preparation.
The effects of lignocaine hydrochloride on hypoxic pulmonary vasoconstriction in the presence and absence of nitrous oxide were examined during constant-flow perfusion of the left lower lobe. Lignocaine had no effect on lobar pulmonary vascular resistance during lobar ventilation with oxygen or 7% oxygen in nitrogen. The substitution of nitrous oxide for nitrogen diminished the hypoxic vasoconstrictor response, whilst the subsequent infusion of lignocaine during 7% oxygen in nitrous oxide increased the response to a value which was not significantly different from that produced by 7% oxygen in nitrogen alone.
D000818:Animals; D004285:Dogs; D008012:Lidocaine / Q000494:pharmacology*; D008168:Lung / Q000098:blood supply* / Q000187:drug effects; D009609:Nitrous Oxide / Q000494:pharmacology*; D010100:Oxygen / Q000502:physiology*; D010477:Perfusion; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D008012:Lidocaine; D009609:Nitrous Oxide; D010100:Oxygen