Treatment of gonorrhea with clavulanate-potentiated amoxicillin (Augmentin).
One hundred sixty-one patients with culture-proved Neisseria gonorrhoeae infection were treated with a single oral dose of amoxicillin trihydrate (3 g) and potassium clavulanate (Augmentin, 0.25 g). Of 153 patients infected with non-penicillinase-producing strains of N. gonorrhoeae, 139 (91%) were cured, and five (62.5%) of eight patients infected with penicillinase-producing N. gonorrhoeae were cured. Augmentin was successful in eradicating N. gonorrhoeae from the rectum; 30 (97%) of 31 such infections were cured.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D002969:Clavulanic Acids / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010405:Penicillinase / Q000096:biosynthesis
D002969:Clavulanic Acids; D004338:Drug Combinations; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D010405:Penicillinase