[Study on human lymphoblastoid interferon-alpha (MOR-22): Part II. Anticellular effects].
The direct and indirect anti-cell proliferation effects of IFN-alpha produced by BALL-1 cells were examined. Of 23 cell lines, 7 including 2 normal diploids were resistant to a dose 1000 IU/ml of IFN-alpha. On the other hand, 16 cell lines were sensitive and showed IC50 values of less than 1000 IU/ml. This anti-cell proliferation spectrum showed no specificity to tumor origin and its activity was reversible. Cellular oncogene expression was markedly suppressed by IFN-alpha treatment. This finding showed that there might be some correlation between anti-cell proliferation activity and anti-oncogene expression activity. Furthermore, by activating natural killer cell activity and antibody dependent cell-mediated cytotoxicity, IFN-alpha potentiated indirect anti-cell activity.
D000920:Antibody-Dependent Cell Cytotoxicity; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology; D009857:Oncogenes; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D007370:Interferon Type I; D012333:RNA, Messenger