[Effect of a ticarcillin-clavulanic acid (timentin) combination on bacteria resistant to ticarcillin].
Sixty-nine ticarcillin-resistant strains (57 Gram negative bacilli and 12 S. aureus) were tested: MICs and MBCs were determined for clavulanic acid, ticarcillin, and both agents combined using a liquid micromethod. MICs were compared to results of disk antibiotic sensitivity tests. While clavulanic acid exhibits little antibacterial activity, its action is synergistic with that of ticarcillin making 100% of Staphylococci and 84.2% of Gram negative bacilli susceptible. Among the Gram negative bacilli tested, distribution is as follows: E. coli (9/9), Klebsiella (10/14), Enterobacter (1/3), Serratia (8/8), Proteus, Providencia (8/8), Salmonella (2/2), Acinetobacter (4/4), and Pseudomonas (6/9). Although strong bacteriostatic and bactericidal activities are already achieved with 4 mg, the best results are obtained with timentin 8 mg.
D000150:Acinetobacter / Q000187:drug effects; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects; D011532:Providencia / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D012705:Serratia / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects*; D013982:Ticarcillin / Q000494:pharmacology*
D002969:Clavulanic Acids; D010406:Penicillins; D019818:Clavulanic Acid; D013982:Ticarcillin
Activité de l'association ticarcilline-acide clavulanique (timentin) sur des germes résistants à la ticarcilline.