Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated damage.
Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and cutaneous lesions. The second case responded to prednisone therapy.
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D000936:Antigen-Antibody Complex / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D005779:Immunodiffusion; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests; D013300:Streptokinase / Q000009:adverse effects*
D000936:Antigen-Antibody Complex; D013300:Streptokinase