Interaction of gentamicin, dibekacin, netilmicin and amikacin with various penicillins, cephalosporins, minocycline and new fluoro-quinolones against Enterobacteriaceae and Pseudomonas aeruginosa.
Thirty strains of Enterobacteriaceae and ten strains of Pseudomonas aeruginosa were selected to study the in-vitro activity of various combinations containing aminoglycosides, by the checkerboard method. The following aminoglycosides: gentamicin, dibekacin, netilmicin and amikacin were used in combination with each of the following: ampicillin, ticarcillin, piperacillin, cefazolin, cefuroxime, ceftazidime, norfloxacin, enoxacin and minocycline. Synergy was not a constant feature of beta-lactam+aminoglycoside combinations. Discrepancies occurred with the same strain submitted to combinations containing different aminoglycosides. The combinations containing new quinolones+aminoglycosides were usually additive, although occasionally synergy occurred. The combination minocycline+aminoglycoside was usually additive but partial antagonism (FIC or FBC index: 1 X 5- less than 2) occurred in 10 to 40% of the strains depending on the aminoglycoside. The combinations of beta-lactams with dibekacin or netilmicin most frequently produced partial or full synergy against strains of Ps. aeruginosa susceptible to all four aminoglycosides tested.
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D003982:Dibekacin / Q000494:pharmacology; D004347:Drug Interactions; D004755:Enterobacteriaceae / Q000187:drug effects*; D005839:Gentamicins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D010406:Penicillins; D011804:Quinolines; D003982:Dibekacin; D009428:Netilmicin; D000583:Amikacin