Hemodynamic responses of the acutely stressed neonatal right ventricle: a maturational study in lambs.
Right ventricular Starling responses to acute volume infusion in newborn lambs were compared to those in older groups of lambs. When peak stroke volume/kg was reached during infusion, right ventricular end-diastolic pressures for the newborn group were significantly lower (p less than 0.001) than those obtained for older groups, in spite of significantly higher resting and peak stroke volumes in the two younger groups. Newborn lambs developed tricuspid regurgitation and right-to-left foraminal shunting, demonstrated by echocardiography, at a mean end-diastolic pressure of 7.5 mm Hg. No right-to-left shunting was noted in older lambs. This study demonstrated a blunted Starling response in the newborn lamb's right ventricle. The response to volume loading improved with maturation, but was still less than that reported for the left ventricle. Clinical implications regarding right ventricular immaturity and inadequate response to altered hemodynamic situations are raised.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004452:Echocardiography; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006439:Hemodynamics; D012756:Sheep; D012965:Sodium Chloride; D013318:Stroke Volume
D012965:Sodium Chloride