title: Factor VIII related antigen in gestational trophoblastic disease.
abstract: Serum factor VIII related antigen (factor VIII R:Ag) levels were determined in 34 patients with hydatidiform mole at diagnosis and at 2, 4 and 6 weeks after evacuation of uterus and in 272 normal pregnant women. Serum factor VIII R:Ag levels in molar pregnancies before evacuation of the uterus were significantly higher than those in normal pregnancies of the same gestation age. Serum factor VIII R:Ag levels in the group of patients with residual trophoblastic disease were significantly higher than those in the group without residual trophoblastic disease before evacuation and at 6 weeks after evacuation of uterus, but there is considerable overlap in the levels of factor VIII R:Ag between the two groups of patients especially before evacuation of uterus. Factor VIII R:Ag level does not appear to be an useful marker in predicting the outcome of hydatidiform mole.
mesh_terms: D000941:Antigens / Q000032:analysis*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000276:immunology*; D011247:Pregnancy; D011379:Prognosis; D013997:Time Factors; D014594:Uterine Neoplasms / Q000276:immunology*; D014841:von Willebrand Factor
chemical_list: D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII