title: Correlations of sinus, conical elevation, median depression of the lower lip and types of oral clefts.
abstract: The incidence of autosomal dominantly inherited Van der Woude's syndrome among Finnish patients with cleft lip and palate CL(P) and with isolated cleft palate (CP) is approximately 2.5%. The incidence of conical elevation of the lower lip (CE) is 39% in CP and 0.8% in CL(P) patients. A pathogenetic similarity of sinuses and CE's was noted. The following classification was used to study associations between sinuses and CE's: (1) sinus; bilateral, unilateral, atypical; (2) CE: bilateral, unilateral; (3) median depression of the lower lip (MD); (4) combined sinus and CE; (5) combined CE and MD. According to the classification developed, a group of 77 sinus patients and 156 CE and/or MD patients was classified in subgroups of CL(P), CP, Pierre Robin anomalad (PR) and non-cleft subjects. The findings were: the sinus was bilateral on 52%, unilateral in 34% and atypical in 14%; the CE without associated sinus was bilateral in all cases; the sinus was associated with CE in 77% of all sinus subjects. The highly increased incidence of the CE in the CP (92%) and in the CL(P) (61%) sinus groups compared to the incidences of CE in these groups in general (39% and 0.8%) shows a close relationship between these 2 disorders of the lower lip, but the similarity of the genetic etiology still remains unclear.
mesh_terms: D002648:Child; D002971:Cleft Lip / Q000145:classification*; D002972:Cleft Palate / Q000145:classification*; D005260:Female; D006801:Humans; D008046:Lip / Q000002:abnormalities* / Q000473:pathology; D008297:Male