[The role of beta-lactamases and the permeability barrier in resistance to beta-lactam antibiotics].
The role played by beta-lactamases and by permeability barrier in resistance to beta-lactam antibiotics was investigated in 250 clinical isolates of Enterobacteriaceae. The data obtained showed that in 73 strains (52.9%) was a significant correlation between the specific enzyme activity and resistance, however in 38 strains (27.5%) an essential role was played by permeability barrier because the addition of subinhibitory levels of EDTA produced markedly reduction in the MIC.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004492:Edetic Acid / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D004492:Edetic Acid; D001618:beta-Lactamases
Ruolo delle beta-lattamasi e della barriera di permeabilità nella resistenza agli antibiotici beta-lattamici.