Xanthine calculi in the patient with the Lesch-Nyhan syndrome associated with urinary tract infection.
A Japanese boy with Lesch-Nyhan syndrome who passed xanthine calculi is reported. After pyelolithotomy for a left renal stone, made up of ammonium urate, associated with urinary tract infection, a high dose of allopurinol was given because of the persistence of pyuria. In the present case, the administration of a high dose of allopurinol, given for the prevention of ammonium urate stone formation in infected urine, induced xanthine calculi formation and we had difficulty in the management of this patient with Lesch-Nyhan syndrome associated with urinary tract infection. However, we believe it a basic necessity to cure our patient of his urinary tract infection and prevent recurrent ammonium urate stone formation because of the risk of renal deterioration.
D000493:Allopurinol / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D013293:Enterococcus faecalis; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced / Q000652:urine*; D007926:Lesch-Nyhan Syndrome / Q000652:urine*; D008297:Male; D011512:Proteus Infections / Q000652:urine; D000644:Quaternary Ammonium Compounds / Q000652:urine; D013290:Streptococcal Infections / Q000652:urine; D014527:Uric Acid / Q000652:urine; D014552:Urinary Tract Infections / Q000652:urine*; D019820:Xanthine; D014970:Xanthines / Q000652:urine*
D000644:Quaternary Ammonium Compounds; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D000493:Allopurinol