[Cyclic parenteral nutrition in children and glucose metabolism].
The effect of cyclic perfusion on glucose metabolism and insulin secretion was determined in 10 children under prolonged parenteral nutrition according to glycosylated hemoglobin (HbA1c) levels and C-peptide urinary excretion. Lack of glycosuria and increase in HbA1c levels (m: 4.4 +/- 0.7%) indicates a good regulation of glycemia. A ten times increase in urinary C-peptide (m: 47.2 +/- 33.3 nmol/m2-1) as compared with controls shows an hypersecretion of insulin induced by the high infusion delivery of glucose. This hypersecretion of insulin, which probably involves long-term risks, may be reduced if parenteral nutrition does not contain more than the energetic requirements for growth and if about 30% of the energetic intake is given as a lipid perfusion.
D000293:Adolescent; D002096:C-Peptide / Q000652:urine; D002648:Child; D005947:Glucose / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006029:Glycosuria / Q000175:diagnosis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007410:Intestinal Diseases / Q000378:metabolism / Q000628:therapy*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D013997:Time Factors
D002096:C-Peptide; D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin
Nutrition parentérale cyclique chez l'enfant et métabolisme du glucose.