title: Lysinoalanine: absence of mutagenic response in the Salmonella/mammalian-microsome mutagenicity assay.
abstract: Lysinoalanine (N epsilon-(DL-2-amino-2-carboxyethyl)-L-lysine) was tested for mutagenicity in the Ames Salmonella/mammalian-microsome mutagenicity assay. No mutagenic response was detected at doses up to 5 mg/plate when samples were pre-incubated without S-9 mix, nor when they were pre-incubated with S-9 mix prepared from Aroclor 1254-induced rat liver or kidney. The results indicate that the stereoisomers of lysinoalanine likely to be present in the greatest proportions in processed foods are not mutagenic in the Ames assay.
mesh_terms: D000818:Animals; D007684:Kidney Tubules / Q000187:drug effects; D008239:Lysine / Q000031:analogs & derivatives*; D008241:Lysinoalanine / Q000633:toxicity*; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism; D051381:Rats; D012475:Salmonella / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D009153:Mutagens; D008241:Lysinoalanine; D008239:Lysine