Obstructive airway disease as a risk factor for asbestos-associated malignancy.
A case-control study of a heavily asbestos-exposed group was performed to determine if obstructive airway disorder is an independent risk factor for developing asbestos-associated malignancies. From a group of 1,500 asbestos workers who had previously undergone careful evaluation, 18 case employees were identified. Each case employee was matched by smoking status, pack-years, age, and years of asbestos exposure to a single referent, a member of the same exposed population known to be free of malignancy. The spirometry results, obtained prior to the clinical manifestation of the cancer, were compared. The FEV1/FVC ratio and the FEV1/height3 ratio were lower (P less than .05, P less than .10, respectively) in the case employees. These results suggest that obstructive airway disease may be an independent risk factor for cancer.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008175:Lung Neoplasms / Q000209:etiology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology; D009784:Occupational Diseases / Q000209:etiology*; D012306:Risk; D012907:Smoking; D013147:Spirometry; D013997:Time Factors
D001194:Asbestos