Translocation (19;?) in two stage II neuroblastomas.
Chromosomes of two abdominal neuroblastomas (stage II) from a 10-month-old male infant and a 6-year-old girl were analyzed. A modal chromosome number of 70 and 46, respectively, was found. Neither double minute chromosomes (DM) or homogeneously staining regions (HSR), nor visible structural abnormalities of chromosome #1 could be detected. However, a common aberration was found to be a translocation on the short arm of chromosome #19. After tumor resection, both children are alive without any evidence of tumor disease.
D000008:Abdominal Neoplasms / Q000235:genetics*; D002648:Child; D002903:Chromosomes, Human, 19-20; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008677:Metaphase; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics*; D014178:Translocation, Genetic