[Effect of chlorgyline on gamma-aminobutyric acid levels in hyperoxia].
Chlorgyline, an inhibitor of type A monoamine oxidase, administered to rats prevented oxygen-induced decrease in gamma-aminobutyric acid brain content in hyperoxia. At the same time chlorgyline had an overall protective effect, increasing two-fold the period prior to the development of oxygen convulsions. The data suggest an important role of the modification of monoamine oxidase catalytic properties in the development of oxygen-induced intoxication and, particularly, in the decrease of gamma-aminobutyric acid content in hyperoxia.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology*; D005260:Female; D008297:Male; D010100:Oxygen / Q000633:toxicity*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011437:Propylamines; D005680:gamma-Aminobutyric Acid; D003010:Clorgyline; D010100:Oxygen
Vliianie khlorgilina na uroven' gamma-aminomaslianoĭ kisloty pri giperoksii.