title: Studies in comparative chemical mutagenesis.
abstract: This paper presents a review of various collaborative studies in comparative mutagenesis. The following studies are briefly described: (1) the chemical mutagenesis programme of the European Community, (2) Drosophila studies with various alkylating agents of different s (Swain-Scott) factors, (3) the evaluation by the International Commission for Protection against Environmental Mutagens and Carcinogens (ICPEMC) Committee 1, (4) the Environmental Protection Agency's Gene-Tox Programme, (5) the first and second United Kingdom Environmental Mutagen Society (UKEMS) collaborative studies, and (6) the International Programme on Chemical Safety (IPCS) collaborative study on in vitro tests. The need for chemical dosimetry is emphasized. One of the main conclusions is that, of the mammalian point mutation assays, the L5178Y (TFTR, trifluorothymidine resistant) system showed greatest detection capability in the second UKEMS study. The consensus conclusion of the IPCS in vitro study was that chromosomal aberrations are considered to be the optimal assay for complementing the Salmonella assay and offer the additional advantage that aneuploidy, polyploidy, and sister chromatid exchanges can also be easily assessed.
mesh_terms: D000477:Alkylating Agents; D000818:Animals; D001419:Bacteria / Q000235:genetics; D002273:Carcinogens; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000235:genetics; D005062:European Union; D051379:Mice; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens; D006113:United Kingdom; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D000477:Alkylating Agents; D002273:Carcinogens; D009153:Mutagens