Effects of aspirin and propranolol on feline platelet aggregation.
Three groups of cats were given aspirin in single dosages of 5, 10, and 25 mg/kg. A 4th group was given 2 dosages of 25 mg/kg, 3 days between doses. The degree of inhibition of platelet function and the duration of antagonism to platelet aggregation were studied. The dosage of 25 mg/kg (single and repeated) consistently inhibited platelet function, and the effects lasted 3 to 5 days. Additive drug effect was not noted in group 4, since the 2nd dosage antagonized platelet function to a degree and duration similar to the effects of the 1st. The dosage of aspirin recommended for antiplatelet activity in the average-sized cat (3 kg) equals approximately 1 pediatric aspirin (90 mg) given twice a week. Propranolol, given to cats at dosages of 2.5 to 15 mg had no effect on platelet aggregation.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D002415:Cats / Q000097:blood*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology*
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D011433:Propranolol; D001241:Aspirin