Filamentous structures morphologically similar to viral nucleocapsids in otosclerotic lesions in two patients.
Two of four patients with active stapedial otospongiosis had abnormal filamentous structures in osteoblast-like cells. These structures were rare in these cells and did not occur in any other cells. The structures were 17 nm wide and clustered in a loose skein in dilated cisternae of the rough endoplasmic reticulum. They resembled the nucleocapsids of subacute sclerosing panenecephalitis, a variant of measles virus.
D002213:Capsid; D004429:Ear Ossicles / Q000648:ultrastructure*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D010006:Osteoblasts / Q000648:ultrastructure; D010010:Osteoclasts / Q000648:ultrastructure; D010040:Otosclerosis / Q000473:pathology*; D013199:Stapes / Q000648:ultrastructure*