Changes in neutrophil alkaline phosphatase patterns in a case of chronic myelomonocytic leukemia.
In neutrophils from a 75-year-old woman suffering from chronic leukemia, an abnormal alkaline phosphatase (ALP) was observed, characterized by a significant increase in neutrophil alkaline phosphatase (NAP) activity, associated with an ectopic expression of two isoenzymes: a thermolabile ALP similar to the early placental form (or non-Regan variant), and a heat-stable isoenzyme closely related to the Nagao isoenzyme. The presence of these oncodevelopmental NAP isoenzymes in a myeloproliferative syndrome has previously not been reported.
D000368:Aged; D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000097:blood*; D007930:Leucine / Q000494:pharmacology; D007951:Leukemia, Myeloid / Q000201:enzymology*; D009504:Neutrophils / Q000201:enzymology*; D010649:Phenylalanine / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
D007527:Isoenzymes; D010649:Phenylalanine; D014508:Urea; D000469:Alkaline Phosphatase; D007930:Leucine