Central muscarinic receptors and male rat sexual behavior: facilitation by oxotremorine but not arecoline or pilocarpine in methscopolamine pretreated animals.
Oxotremorine (0.1-0.8 mg/kg IP), but not arecoline (12-48 mg/kg IP), or pilocarpine (5-20 mg/kg IP), reduced both the number of intromissions to ejaculation and the ejaculation latency in methscopolamine-pretreated male rats. The effects of oxotremorine, (0.4 mg/kg IP) were completely antagonized by the administration of scopolamine (0.4 mg/kg IP). Methscopolamine (3-12 mg/kg IP), or scopolamine (0.2-0.4 mg/kg IP) did not by themselves produce any statistically significant effects on male rat sexual behavior.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D019832:N-Methylscopolamine; D010095:Oxotremorine / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000494:pharmacology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D011976:Receptors, Muscarinic; D012602:Scopolamine Derivatives; D010862:Pilocarpine; D001115:Arecoline; D010095:Oxotremorine; D019832:N-Methylscopolamine