Effect of volume of water taken with diazepam tablets on absorption.
Thirty-three patients received either 10 ml (group A) or 50 ml (group B) of water with diazepam tablets as premedication while in the supine position. Plasma diazepam concentrations were measured, a delay in the attainment of the peak plasma concentration being taken as an indication of delayed absorption and oesophageal hold-up. There was no difference between the two groups, although in an important minority (16.7% (group A) and 20% (group B], absorption was delayed to beyond 60 min. There was a wide scatter of plasma diazepam concentrations in both groups. Dysphagia during swallowing did not appear to delay absorption.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003975:Diazepam / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004326:Drinking; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D003975:Diazepam