[Continuous venous infusion of 5-fluorouracil (5-FU) under total parenteral nutrition (TPN) in advanced gastric cancer].
Continuous venous infusion of 5-FU was investigated in patients with advanced gastric cancer under TPN. In preliminary research Yoshida Sarcoma-bearing rats were continuously infused with 5-FU at a dose of 20 mg/kg/day under TPN. The 5-FU level in the tumor was 2-5 times higher than that in the kidney, stomach, intestine and liver, and 40-50 times higher than that in serum. Advanced gastric cancer patients were continuously infused with 5-FU at a dose of 500 mg/day under TPN. Serum 5-FU level was constantly maintained at 0.05 mcg/ml during the infusion period. The effects of 5-FU continuously infused with other anticancer agents and TPN were satisfactory with regard to anticancer response and general condition. In conclusion, in advanced cancer, 5-FU is recommended for use in continuous infusion at a dose of 500 mg/day under TPN.
D000818:Animals; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010289:Parenteral Nutrition, Total; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy*
D005472:Fluorouracil