Liquid chromatographic method for perphenazine and its sulfoxide in pharmaceutical dosage forms for determination of stability.
A liquid chromatographic method is described for determination of perphenazine and perphenazine sulfoxide in representative dosage forms. Sulfoxide levels were nondetectable or less than 1% in tablets and in an injectable product. Sulfoxide levels increase with time in some syrup formulations and may be as high as 11% in syrup formulations before their expiration date.
D002853:Chromatography, Liquid; D004355:Drug Stability; D010546:Perphenazine / Q000032:analysis*; D012451:Safrole / Q000031:analogs & derivatives / Q000032:analysis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D013607:Tablets; D010546:Perphenazine; D012451:Safrole; C005746:sulfoxide