[Comparison of chain breaks produced in DNA in vivo by gamma rays and neutrons; hypothesis of a new DNA radiolesion].
Using the method of alkaline elution for the treatment of cell DNA in chinese hamster fibroblasts irradiated with low doses of either cobalt-60 gamma rays or p (34 MeV) Be neutrons, we determined the kinetics of radio-induced strand breaks. The comparison gamma rays-neutrons reveals important discrepancies which suggest that neutrons induce a so for unknown reaction in DNA simultaneously with single and double strand breakage. This observation could contribute to explain the high RBE value of high LET particles.
D000818:Animals; D002999:Clone Cells / Q000528:radiation effects; D006224:Cricetinae; D004247:DNA / Q000528:radiation effects*; D005720:Gamma Rays; D007668:Kidney; D007700:Kinetics; D009502:Neutrons; D014462:Ultrafiltration
D004247:DNA
Comparaison des ruptures de chaîne produites dans l'ADN in vivo par les rayons gamma et les neutrons; hypothèse d'une nouvelle radiolésion de l'ADN.