[Fundamental study on intra-arterial chemotherapy with direct hemoperfusion].
Pharmacokinetics of anti-neoplastic agents (Cis-platinum: CDDP, Mitomycin C: MMC and Doxorubicin hydrochloride: ADM) in intra-arterial infusion chemotherapy with direct hemoperfusion (DHP) for bladder cancer were compared using dogs. For all of the three drugs, the blood drug concentration in peripheral veins of the group with DHP was lower than that of the group without DHP. The clearance of the DHP cartridges was relatively high, 82 ml/min for MMC, 76-79 ml/min for ADM, and 78 ml/min for CDDP at the end of the first 30 minutes. The clearance of MMC and ADM remained high throughout the following 90 minutes, but that of CDDP decreased with the increase in DHP operating time. The calculated amounts of the drugs adsorbed in the cartridges were 45.6 mg for CDDP, 19.2 mg for MMC and 42.0 mg for ADM, which were nearly half of the total administered doses. The urinary recovery rate of CDDP was 22.3% in the group with DHP and 41.8% in the group without DHP. The actual amount of CDDP adsorbed in the cartridges was 48.3% of the total administered dose, which makes the sum of urinary recovery rate and DHP adsorption rate 70%. The use of DHP was effective to eliminate the renal toxicity of the drug. This study shows that it is most effective when the use of DHP is completely simultaneous with intra-arterial infusion chemotherapy from the start to the end.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000378:metabolism; D000970:Antineoplastic Agents / Q000378:metabolism*; D002945:Cisplatin / Q000008:administration & dosage / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage / Q000378:metabolism; D006464:Hemoperfusion; D007261:Infusions, Intra-Arterial; D007700:Kinetics; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin; D002945:Cisplatin