Inhibition of cell proliferation by D-ribose and deoxy-D-ribose.
D-Ribose and deoxy-D-ribose inhibited DNA, RNA, and protein synthesis in a wide variety of cells (dividing and nondividing, normal and neoplastic, freely floating and substrate adhering, human and murine) at concentrations at which other monosaccharides have little or no effect. Inhibition was irreversible and proportional to the sugar concentration and time of contact. However, the first effects were seen only after 24 hr of incubation and progressed slowly to cell death. Whether the two sugars share the same mechanisms of action is not known. In any case, they deeply disturb metabolic processes in both dividing and nondividing cells.
D000818:Animals; D001853:Bone Marrow; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004247:DNA / Q000032:analysis; D003855:Deoxyribose / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D009132:Muscles; D051381:Rats; D012266:Ribose / Q000494:pharmacology*; D013154:Spleen
D008934:Mitogens; D003855:Deoxyribose; D012266:Ribose; D004247:DNA