title: Serial changes in selected serum constituents in low birth weight infants on peripheral parenteral nutrition with different zinc and copper supplements.
abstract: One hundred and five infants of birth weight 2000 g or less who received peripherally administered parenteral nutrition for periods of three or more weeks, were randomly assigned to groups receiving different amounts of zinc and copper supplement. The blood concentrations of zinc, copper, retinol-binding protein, prealbumin, alkaline phosphatase and aspartate transaminase were followed weekly. Mean serum zinc, retinol-binding protein and prealbumin declined significantly over time while alkaline phosphatase rose. Only the group receiving the highest zinc supplement maintained a mean serum zinc concentration within the normal range at seven weeks. No difference in the protein or enzyme concentrations was found between the different zinc supplement groups. No difference was seen in serum copper or ceruloplasmin between copper dose groups although one intravenous supplement was double that of the other.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009751:Nutritional Requirements; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D011228:Prealbumin / Q000378:metabolism; D012177:Retinol-Binding Proteins / Q000378:metabolism; D015032:Zinc / Q000008:administration & dosage* / Q000097:blood
chemical_list: D011228:Prealbumin; D012177:Retinol-Binding Proteins; D003300:Copper; D002570:Ceruloplasmin; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D015032:Zinc