Bronchial hyperreactivity and bronchial obstruction in respiratory viral infection. An attempt to evaluate the relationship.
The aim of this study was to investigate the relation of viral respiratory infection with bronchial hyperreactivity and bronchial obstruction. A viral infection using a live attenuated influenza virus was induced successfully in 10 of 30 patients with chronic obstructive pulmonary disease (COPD) and in 3 subjects without COPD (non-COPD). No significant change in bronchial reactivity and lung function could be found in comparison with the baseline values.
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D007958:Leukocyte Count; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000503:physiopathology; D008297:Male; D012141:Respiratory Tract Infections / Q000150:complications / Q000503:physiopathology*; D014777:Virus Diseases / Q000150:complications / Q000503:physiopathology*; D014797:Vital Capacity
D007252:Influenza Vaccines