Mitomycin C-induced mosaicism in C-band regions of human chromosomes 1, 9, 16, and Y.
In order to test the hypothesis that somatic mosaicism involving C-band polymorphism of human chromosomes 1, 9, 16 may arise from mitotic crossing over, peripheral blood lymphocytes from normal males were treated with mitomycin C, which is known to induce somatic crossing over in lower eukaryotes. Evidence is presented which shows that mitomycin C is able to alter the heterochromatic pattern in human lymphocytes.
D002478:Cells, Cultured; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D003434:Crossing Over, Genetic; D006570:Heterochromatin / Q000187:drug effects / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D009030:Mosaicism; D011110:Polymorphism, Genetic; D014998:Y Chromosome
D006570:Heterochromatin; D008937:Mitomycins; D016685:Mitomycin