title: Inhaled anaesthetics have no effect on fertility in Drosophila melanogaster.
abstract: The potential effects of enflurane, isoflurane, halothane, fluroxene and nitrous oxide on mortality and fertility in Drosophila melanogaster were examined. The LD50 value 1 day after exposure for 1 h was the same for males and females and was about 8% for enflurane, isoflurane and halothane, about 20% for fluroxene, and greater than 100% for nitrous oxide. Male and female fertility, however, were not affected by any of the anaesthetics, even at concentrations well above those used clinically.
mesh_terms: D000769:Anesthesia, Inhalation / Q000009:adverse effects; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D008297:Male
chemical_list: D000777:Anesthetics