Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats.
The promoting effect of trisodium nitrilotriacetate monohydrate (Na3NTA X H2O) on two-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at levels of 0.01 and 0.05% was investigated. Administration of 2.0% Na3NTA X H2O significantly increased both the incidence and the number per 10 cm of basement membrane of preneoplastic lesions and papillomas of the urinary bladder in rats pretreated with 0.05% BBN. This result shows that Na3NTA X H2O has weak promoting activity in urinary bladder carcinogenesis.
D000085:Acetates / Q000633:toxicity*; D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D002273:Carcinogens; D008297:Male; D009571:Nitrilotriacetic Acid / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000652:urine
D000085:Acetates; D002273:Carcinogens; D002085:Butylhydroxybutylnitrosamine; D009571:Nitrilotriacetic Acid