title: Current brain tumour models with particular consideration of the transplantation techniques. Outline of literature and personal preliminary results.
abstract: The most well known brain tumour models will be discussed. It is a series of animal experiments with an induced tumour and with heterologous and homologous transplantation. This work will deal especially with technical problems, which have not so far been satisfactorily resolved. With the aid of a stereotaxic operation method, the exactness of the technique of transplantation could be improved. The tumour contamination problem of the injection pathway as well as of the cerebral spinal fluid compartment is satisfactorily resolved. The authors have at their disposal a standardized cerebral glioma model in the rat in order to study the interstitial chemotherapy of brain tumours.
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004195:Disease Models, Animal; D005038:Ethylnitrosourea; D005910:Glioma / Q000139:chemically induced / Q000188:drug therapy*; D006085:Graft Survival; D007427:Intracranial Pressure; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005038:Ethylnitrosourea