Liposome-delivered phosphatidylcholine enhances the acetylcholine sensitivity of dystrophic mouse myotubes.
Myotubes were obtained in vitro from satellite cells of normal and dystrophic C57BL/6J/dydy mice. The acetylcholine sensitivity (mV/nC) of dystrophic myotubes determined with conventional electrophysiological techniques, was lower than that of normal myotubes. Incubation of dystrophic myotubes with liposomes containing phosphatidylcholine (a lipid present in higher amounts in normal adult muscle) significantly increased their acetylcholine sensitivity.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation; D004594:Electrophysiology; D008081:Liposomes / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000187:drug effects*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism*
D008081:Liposomes; D010713:Phosphatidylcholines; D000109:Acetylcholine