title: Antibiotic irrigation prophylaxis in the high-risk cesarean section patient.
abstract: Two hundred twenty-three women who underwent cesarean section delivery were studied to assess the effectiveness of operative antibiotic irrigation in preventing postoperative uterine infection. Patients were prospectively randomized into high-risk and low-risk groups according to length of labor, and received irrigation with either a 2 gm solution of cefamandole or normal saline solution, or no irrigation. Infection rates of 48.6% and 54.8% were observed in high-risk patients given either saline solution or no irrigation, respectively. Three of 27 high-risk patients (11.1%) given antibiotic irrigation developed metritis. The authors find this method of preventing infection to be advantageous in terms of both efficacy and minimization of antibiotic exposure.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002435:Cefamandole / Q000008:administration & dosage*; D002585:Cesarean Section / Q000379:methods*; D005260:Female; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000191:economics / Q000382:microbiology; D007743:Labor, Obstetric; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D012306:Risk; D007507:Therapeutic Irrigation; D013997:Time Factors; D014591:Uterine Diseases / Q000191:economics / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D002435:Cefamandole