A case of progressive hemichorea responsive to high-dose reserpine.
A 74-year-old woman developed a slowly progressive hemichorea starting 3 weeks after discontinuation of low-dose amitriptyline and perphenazine. The duration of neuroleptic exposure was 3 months. The chorea was initially well controlled on 5.25 mg/day of reserpine, but after 21 months, required 2.0 mg/day. No complications of reserpine occurred.
D000368:Aged; D000639:Amitriptyline / Q000009:adverse effects*; D002819:Chorea / Q000139:chemically induced / Q000188:drug therapy*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D010546:Perphenazine / Q000009:adverse effects*; D012110:Reserpine / Q000008:administration & dosage*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology
D000639:Amitriptyline; D012110:Reserpine; D010546:Perphenazine