title: Chelation in metal intoxication XVII: Antidotal efficacy of polyaminocarboxylic acids on acute chromate toxicity.
abstract: Some polyaminocarboxylic acids containing amino and carboxyl groups as metal binding sites in different structural arrangements were evaluated for their relative efficacy in protecting against acute chromate intoxication in mice. Nitrilotriacetic acid (NTA) and 1,2 cyclohexylenediamine tetraacetic acid (CDTA) were most effective in preventing mortality (50-70%) due to a lethal dose of potassium chromate at one-tenth of their respective LD50.
mesh_terms: D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000931:Antidotes; D001665:Binding Sites; D002840:Chromates / Q000378:metabolism / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009571:Nitrilotriacetic Acid / Q000494:pharmacology; D017680:Potassium Compounds
chemical_list: D000596:Amino Acids; D000931:Antidotes; D002840:Chromates; D017680:Potassium Compounds; C005390:CDTA; C027373:potassium chromate(VI); D004492:Edetic Acid; D009571:Nitrilotriacetic Acid