title: [Differential cell mutability during oogenesis and exposure to ethyleneimine and ethylmethane sulfonate in different Drosophila melanogaster lines].
abstract: The rate of recessive sex-linked lethal mutations (RLM) was estimated by brood pattern method at different stages of oogenesis, initially, in the wild-type R-86 strain of Drosophila melanogaster after treatment with EI and EMS. The former which is known to induce dominant lethals in mature oocytes of the 14th stage with a high frequency was equally effective in inducing RLM in oocytes of different age and in oogonia. EMS which does not induce dominant lethals when used as vapour was shown to increase RLM frequency in mature fraction of oocytes (the 14A stage only). Similar type of different mutability was found in mutagen-sensitive strain mus-201G1 and in the control 3-4 strain having the same genetical background as mus mutation. Female germ cells of mus-201G1 strain appeared to have a higher mutability in the case of EI, though no differences in mutability between these strains after EMS treatment were registered. The data are discussed in view of the specificity of primer damages occurring as a result of comparable mutagens action and participation of different repair systems in elimination of these damages.
mesh_terms: D000818:Animals; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D004331:Drosophila melanogaster; D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D005260:Female; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D008040:Genetic Linkage / Q000187:drug effects; D009154:Mutation; D009865:Oocytes / Q000187:drug effects*; D009866:Oogenesis / Q000187:drug effects*; D009867:Oogonia / Q000187:drug effects; D013997:Time Factors
chemical_list: D001388:Aziridines; D001389:Azirines; D005020:Ethyl Methanesulfonate
vernacular_title: Differentsial'naia mutabil'nost' kletok v khode oogeneza pri deĭstvii étilenimina i étilmetansul'fonata u raznykh liniĭ Drosophila melanogaster.