[Transformation of skeletal muscle by progressive sequential stimulation with a view toward its use as a myocardial substitute].
Progressive sequential stimulation of a skeletal muscle using trains of 30 Hz impulses with increasing frequencies from 20/min. to 80/min. within 3 months, allowed us to obtain in goats a transformation of the fast twitch glycolytic muscular fibers into fatigue resistant slow twitch oxidative muscular fibers. The conditioned muscle can be used in the treatment of various myocardial lesions or to reinforce cardiac contractility in severe cardiac insufficiencies. The first clinical case successfully operated upon is reported.
D000328:Adult; D000818:Animals; D009202:Cardiomyopathies / Q000628:therapy*; D004558:Electric Stimulation / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D005350:Fibroma / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006041:Goats; D006338:Heart Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009119:Muscle Contraction; D009132:Muscles / Q000502:physiology*; D009200:Myocardial Contraction
Transformation d'un muscle squelettique par stimulation séquentielle progressive en vue de son utilisation comme substitut myocardique.