title: Present status of antimycotics.
abstract: The four principal classes of antimycotic drugs used in clinical practice are the polyene macrolide antibiotics, the synthetic imidazole drugs, griseofulvin and 5-fluorocytosine. Drugs in the first two groups interfere with the synthesis and functioning of cell membranes and the others interfere with nuclear metabolism. The mode of action of 5-fluorocytosine is well understood, but the detailed molecular mechanisms by which the other compounds work have yet to be elucidated.
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents