Effects of hyperthermia on normal or neoplastic rat liver.
An experimental study was conducted in rats to evaluate the sensitivity of the liver to infrared hyperthermia. A 15-min hyperthermia session treating only the liver was done in rats with a normal hepatic parenchyma and in rats with hepatocarcinoma induced by chronic 3'-diethylaminoazobenzene intoxication, at various ranges of intrahepatic temperature. In normal rats, 40-42 degrees C hyperthermia was well tolerated, but the mortality rate increased when the intrahepatic temperature exceeded 42 degrees C. In rats with tumors, a 40-42 degrees C hyperthermia session was well tolerated in case of small tumors, but resulted in a high mortality rate in case of large tumors. In all cases, death occurred as a consequence of liver injury. This study using a simple method of hyperthermia defines the thermosensitivity of the neoplastic or normal rat liver and provides a basis for further investigations on the effect of hyperthermia on experimental liver tumors.
D000818:Animals; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D008099:Liver / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D004124:p-Dimethylaminoazobenzene
D004124:p-Dimethylaminoazobenzene