[Experimental model for studying the participation of bone marrow cells in antibody formation].
Participation of bone marrow cells in the production of IgM antibody forming cells (AFC) in the primary immune response to sheep red blood cells (SRBC) in C57Bl/6 and BDA/2 mice was studied. The animals of this line differed in sensitivity to preoral benz(a)pyren (BP) injection. After BP injection a toxical injury of bone marrow cells was observed for two days in DBA 2 mice but was not marked in C57Bl/6 mice. In the former it was followed by a 10-fold decrease of IgMAFC, while no profound changes were noticed in the immune response of the latter. A new model is offered for the evaluation of bone marrow cell participation. A suggestion is made concerning some connection of immunodepression in the bone marrow with the change of the stem hemopoietic precursor differentiation.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology*; D001564:Benzo(a)pyrene / Q000494:pharmacology; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007114:Immunization / Q000379:methods; D007075:Immunoglobulin M / Q000096:biosynthesis; D007422:Intestines / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008862:Microsomes, Liver / Q000201:enzymology; D008954:Models, Biological
D007075:Immunoglobulin M; D001564:Benzo(a)pyrene; D001579:Benzopyrene Hydroxylase
Eksperimental'naia model' dlia izucheniia uchastiia kletok kostnogo mozga v antitelogeneze.