Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats.
The weight of the stomach, small intestine and colon and the mucosal crypt cell production rate of these tissues were significantly decreased after 10 days on an isocaloric TPN diet when compared to orally fed controls. Continuous infusion of recombinant beta urogastrone, at a dose below that needed to inhibit gastric acid secretion, largely prevented this decrease in crypt cell production rate and gastrointestinal tissue weights.
D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects; D007422:Intestines / Q000166:cytology*; D008297:Male; D009929:Organ Size; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D004815:Epidermal Growth Factor