T-cell receptor gene rearrangement in a patient with common acute lymphocytic leukemia.
Using a beta-chain cDNA probe of the T-cell receptor, we detected T-cell receptor gene rearrangement in leukemic cells from an adult patient with common acute lymphocytic leukemia (cALL). The leukemic cells expressed non-T, non-B cell marker profiles (CALLA+, J5+, Leu-1-, Leu-4-, Ia+, B1-, c-Ig mu- and TdT+). This is the first reported case of cALL with T-cell receptor gene rearrangement and/or deletion.
D000328:Adult; D004247:DNA / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000276:immunology; D010677:Philadelphia Chromosome; D011971:Receptors, Immunologic / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology*
D004273:DNA, Neoplasm; D005819:Genetic Markers; D011971:Receptors, Immunologic; D004247:DNA