Blood volume, erythrokinetics and spleen function in thrombocythaemia.
Essential thrombocythaemia was diagnosed in a series of 18 patients on the basis of platelet counts greater than 1,000 X 10(9)/1. Radionuclide studies have been carried out to distinguish thrombocythaemia as a primary disease from polycythaemia vera, myelofibrosis and chronic granulocytic leukaemia presenting with high platelet counts. These have included blood volume and spleen function, and radio-iron (52Fe) has been used to demonstrate the presence of extramedullary (splenic) erythropoiesis. The value of these investigations in distinguishing between the various myeloproliferative disorders associated with thrombocythaemia is illustrated.
D000328:Adult; D000368:Aged; D001810:Blood Volume; D001856:Bone Marrow Examination; D004912:Erythrocytes / Q000000981:diagnostic imaging; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013154:Spleen / Q000378:metabolism / Q000502:physiology; D013920:Thrombocythemia, Essential / Q000503:physiopathology*
D007501:Iron