[The effect of synthetic gonadotropin releasing hormone on the plasma levels of FH and LSH in women with hirsutism and polycystic ovaries].
GN-RH test was performed in 33 women with hirsutism and irregular menstrual cycles. Fourteen patients had polycystic ovary syndrome (PCO) and 19 had idiopathic hirsutism (IH). In the control group, there were 5 healthy women with regular menstrual cycles. Absolute cumulative increase of LH as significantly higher in the examinees with hirsutism than in the control group. A significantly higher net increase of LH was found only in the PCO group. However, absolute and net increase of FSH in examinees with hirsutism did not significantly differ from that in the control group. Patients with PCO had a significantly higher increase of FSH than the IH group. Only the PCO group had a significant correlation between basal LH and LH increase during the test. It was found that patients with hirsutism and irregular menstrual cycles had an increased reactivity of the hypophysis to a direct stimulation with synthetic GN-RH. The degree of disfunction of the gonad axis in women with PCO is significantly higher than in patients with IH.
D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006628:Hirsutism / Q000097:blood* / Q000175:diagnosis; D006728:Hormones / Q000502:physiology; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis
D006728:Hormones; D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Uticaj sintetskog rilizing hormona za gonadotropine na nivo LH i FSH u plazmi u zena sa hirzutizmom i policisticnim ovarijumima.