title: [Adjuvant mono- and polychemotherapy in breast cancer (a randomized study)].
abstract: A clinical study started at the Institute in 1975 embraced 1,228 patients with breast tumors of stages I, II and III. Adjuvant monochemotherapy (six courses of 200 mg Thio-TEPA) was followed by a 24.3% decrease in the death rates for the patients with stage I-II tumors (pT0-2N0-1M0), whereas polychemotherapy (six courses of TMF and CMF)-by 32.4%. A 7.8-9.8% increase in corrected survival (as compared with control) was registered in those patients with less advanced malignancies of the breast (pT0-2N0M0) who had received mono- and polychemotherapy. In patients with pT0-2N0-1M0 tumors treated after the TMF or CMF modalities, survival rates showed a 12.0-16.6% increase, as compared with controls, after 6, 7 and 8 years. The beneficial effect of adjuvant chemotherapy (lower mortality rate matched by higher survival) was reliably established in patients under 50 only.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care; D011878:Radiotherapy; D011897:Random Allocation; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Ad''iuvantnaia mono- i polikhimioterapiia pri rake molochnoĭ zhelezy (randomizirovannoe issledovanie).