Nonprogression of coronary artery atherosclerosis in homozygous familial hypercholesterolemia after 31 months of repetitive plasma exchange.
The effects of plasma exchange performed every two weeks for 31 months in combination with diet and drug therapy were studied in a patient with receptor-defective homozygous familial hypercholesterolemia. Coronary angiography performed three years prior to commencing plasma exchange was compared to angiography 31 months after starting the program. Comparison of the angiograms taken six years apart showed no progression of coronary atheroma in the main left coronary artery in which a 30% narrowing was originally seen. An internal mammary artery-coronary artery bypass remained widely patent and showed no development of atherosclerosis. Plasma cholesterol levels were reduced 46% by plasma exchange, diet and drug compared to diet and drug alone. Achilles tendon xanthoma diminished significantly. It appears that plasma exchange combined with diet and drug therapy, while not producing regression of existing atheromatous lesions, does retard or prevent further progression.
D000125:Achilles Tendon; D000328:Adult; D000792:Angiography; D002784:Cholesterol / Q000032:analysis; D008078:Cholesterol, LDL / Q000032:analysis; D002792:Cholestyramine Resin / Q000627:therapeutic use; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D004452:Echocardiography; D005260:Female; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications* / Q000235:genetics; D010951:Plasma Exchange; D011341:Probucol / Q000627:therapeutic use; D014973:Xanthomatosis / Q000150:complications / Q000628:therapy
D008078:Cholesterol, LDL; D002792:Cholestyramine Resin; D002784:Cholesterol; D011341:Probucol