title: Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis.
abstract: Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004407:Dysgerminoma / Q000150:complications / Q000276:immunology*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications / Q000276:immunology*; D006059:Gonadal Dysgenesis / Q000276:immunology*; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications / Q000276:immunology*; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D007962:Leukocytes / Q000276:immunology; D008297:Male; D014770:Virilism / Q000150:complications
chemical_list: D006182:H-Y Antigen