HLA antigens in hemophiliacs A with or without factor VIII antibodies in a Venezuelan Mestizo population.
Twenty-eight unrelated hemophilia A patients, seven of them with anti-factor VIII antibodies were typed for HLA-A, B, C antigens and 25 of them for HLA-DR. The results show a significant difference in HLA-DR4 frequency between hemophiliacs with antibodies who lack this antigen and hemophiliacs without antibodies, in whom HLA-DR4 is increased as compared to a healthy control series. This data suggests that DR4 may be associated with a factor preventing anti-factor VIII immunization.
D000906:Antibodies; D005169:Factor VIII / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015804:HLA-DR4 Antigen; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D014687:Venezuela
D000906:Antibodies; D006680:HLA Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D005169:Factor VIII