[Characteristics of the effect of different cardiovasotropic preparations on the contractility of separate sections of the myocardium in acute coronary occlusion].
In acute experiments on cats, the effect of nitroglycerin (0,5 mg/kg), obsidan (0,5 mg/kg) and adrenaline (0,005 mg/kg) on the contractility of various segments of the myocardium in acute ischemia state was studied. It is shown that nitroglycerin increases the contractility of the border zone and decreases the compensatory hyperfunction of intact myocardial zones. Obsidan reduces the contractility of all the zones and adrenaline suppresses the border zone contractility despite the marked growth of contractile function of the intact zones and of the heart on the whole. The central-ischemic myocardial zone responded weakly to drug action.
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002415:Cats; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003331:Coronary Vessels; D004353:Drug Evaluation, Preclinical; D004553:Electric Conductivity; D004837:Epinephrine / Q000627:therapeutic use; D008026:Ligation; D009200:Myocardial Contraction / Q000187:drug effects*; D005996:Nitroglycerin / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use
D002317:Cardiovascular Agents; D011433:Propranolol; D005996:Nitroglycerin; D004837:Epinephrine
Osobennosti vliianiia razlichnykh kardiovazotropnykh preparatov na sokratimost' otdel'nykh uchastkov miokarda pri ostroĭ koronarookkliuzii.