MR imaging of the aging brain: patchy white-matter lesions and dementia.
Magnetic resonance (MR) imaging studies of the brain in five elderly patients with non-Alzheimer dementia were compared with those in two groups of nondemented control subjects. Group 1 included five subjects aged 59-66; group 2 included nine subjects aged 74-81. In all of the demented patients and in three of the subjects in the older control group, MR showed diffuse, patchy white-matter lesions. A rating scale was used to grade the severity of the changes. The results suggest a higher incidence of white-matter lesions in elderly patients with non-Alzheimer dementia and in cognitively normal elderly with advancing age.
D000367:Age Factors; D000368:Aged; D000375:Aging; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003071:Cognition; D003704:Dementia / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests