title: [Microsomal and photochemical oxidation of aflatoxin B1].
abstract: The UV irradiation (lambda = 362 nm) of aflatoxin B1 (AfB1) dissolved in water resulted in the formation of an oxidized product. The process was not inhibited by ionol, a routine inhibitor of the radical processes. The oxidized product was not found in the system where AfB1 was metabolized by the 3-methylcholanthrene-activated rat liver microsomes. It is suggested that the product is identical with 2,3-dihydrodiol of AfB1.
mesh_terms: D016604:Aflatoxin B1; D000348:Aflatoxins / Q000032:analysis / Q000378:metabolism* / Q000528:radiation effects; D000818:Animals; D002273:Carcinogens / Q000032:analysis / Q000378:metabolism* / Q000528:radiation effects; D002851:Chromatography, High Pressure Liquid; D066298:In Vitro Techniques; D007700:Kinetics; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D010782:Photolysis; D051381:Rats; D014466:Ultraviolet Rays
chemical_list: D000348:Aflatoxins; D002273:Carcinogens; D008748:Methylcholanthrene; D016604:Aflatoxin B1
vernacular_title: Mikrosomal'noe i fotokhimicheskoe okislenie aflatoksina B1.