Muscle damage induced by the ionophore A23187 can be prevented by prostaglandin inhibitors and leupeptin.
Frog skeletal muscle incubated in vitro with the ionophore A23187 shows extensive morphological alterations. Myofilament disruption, presumably mediated by excess intracellular calcium, can be partially prevented by preincubating the muscle with inhibitors of prostaglandin synthesis and the lysosomal thiol protease inhibitor leupeptin.
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D000001:Calcimycin / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000633:toxicity; D002118:Calcium / Q000502:physiology; D007976:Leupeptins / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000648:ultrastructure; D009842:Oligopeptides / Q000494:pharmacology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011894:Rana pipiens
D007976:Leupeptins; D009842:Oligopeptides; D011448:Prostaglandin Antagonists; D000001:Calcimycin; C032854:leupeptin; D002118:Calcium