Non-neural malignancy complicating neurofibromatosis in two relatives.
In a family with neurofibromatosis, an affected 16-year-old male developed undifferentiated lymphoma that evolved into acute lymphocytic leukemia. Five years later, his 7-month-old nephew with neurofibromatosis developed a prostatic embryonal rhabdomyosarcoma. This illustrates familial neurofibromatosis complicated by non-neural malignancy in relatives.
D000293:Adolescent; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D009456:Neurofibromatosis 1 / Q000235:genetics*; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics