Dose-dependent occurrence of the aberrant longitudinal bundle in the brains of mice born acallosal after prenatal gamma irradiation.
Two groups of pregnant mice were gamma-irradiated at the 16th gestation day with doses of 2 or 3 Gy. All litters were born acallosal, but while the 3-Gy mice showed a severely hypotrophic neocortex without the aberrant longitudinal bundle typical of early disconnected rodents, in the 2-Gy group the cortex was less deranged and the aberrant bundle appeared consistently underneath the white matter.
D061085:Agenesis of Corpus Callosum; D000818:Animals; D002540:Cerebral Cortex / Q000528:radiation effects; D003337:Corpus Callosum / Q000196:embryology / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D051379:Mice