Quantitative analysis of retinal outer segments in ovine ceroid-lipofuscinosis.
Isolated outer segments from the photoreceptors of the eye were markedly reduced in young animals with ovine ceroid-lipofuscinosis. At 5 months of age, 68% of these structures were lost and by 18 months, no segments remained. Our results suggest that loss of these structures can be identified earlier by quantitative analysis, than by electroretinography.
D000818:Animals; D003720:Densitometry; D004596:Electroretinography; D009472:Neuronal Ceroid-Lipofuscinoses / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010786:Photoreceptor Cells / Q000473:pathology; D012160:Retina / Q000473:pathology*; D012756:Sheep; D012757:Sheep Diseases / Q000175:diagnosis / Q000473:pathology*