title: [Interaction of enzymatically modified low-density lipoproteins with fibronectin].
abstract: Interaction of human low-density lipoproteins (LDL) with homologous fibronectin fixed on collagen-Sepharose was studied. LDL were digested with pepsin, the degree of hydrolysis amounting to 10%. Upon passing modified LDL through a fibronectin-collagen-Sepharose column the desorption of fibronectin occurred. Addition of the increasing amount of fibronectin to the pepsin-treated LDL solution in the presence of Ca2+ ions led to the formation of LDL-fibronectin insoluble complexes. Interaction of native LDL with fibronectin was not observed. The data suggest that enzymatic modification of LDL increasing interaction of modified LDL with fibronectin, a component of extracellular matrix, could promote the accumulation of such LDL in arterial walls.
mesh_terms: D005353:Fibronectins; D006801:Humans; D066298:In Vitro Techniques; D008077:Lipoproteins, LDL; D010434:Pepsin A
chemical_list: D005353:Fibronectins; D008077:Lipoproteins, LDL; D010434:Pepsin A
vernacular_title: Vzaimodeĭstvie fermentativno modifitsirovannykh lipoproteidov nizkoĭ plotnosti s fibronektinom.