Survival effect of coenzyme Q10 and naloxone on experimental stroke gerbils.
Coenzyme Q10 (CoQ10) and the opiate antagonist naloxone were compared as to their effect on the survival of mongolian gerbils with unilateral carotid ligation-induced stroke. Without medication all of the stroke gerbils died within 28 hours, but with a subcutaneous implantation of a 10 mg pellet of naloxone, 20% of the gerbils lived for 4 weeks. When a 250 mg pellet of CoQ10 was implanted subcutaneously, a definite effect on survival was observed, with 45% of the stroke gerbils living for 4 weeks. Considering that the action mechanisms of CoQ10 and naloxone are different, the combined use of these drugs in the treatment of stroke needs to be investigated.
D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000378:metabolism; D003067:Coenzymes; D004579:Electron Transport / Q000187:drug effects; D005849:Gerbillinae; D007977:Levallorphan / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D003067:Coenzymes; D014451:Ubiquinone; D007977:Levallorphan; D009270:Naloxone; C024989:coenzyme Q10