Queuosine metabolism: possible relation to B-cell activation by C8 derivatives of guanosine.
The observed enhancement of B-lymphocyte activation by 8-bromoguanosine and 8-mercaptoguanosine is hypothesized to occur via a "binding protein" which requires a guanine nucleoside as the syn conformer for productive interaction. In addition, because of the 7-substituent, Q nucleoside also is hypothesized to bind as the syn conformer and, therefore, to be a potential B-lymphocyte activator.
D000818:Animals; D000926:Anticodon; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D002352:Carrier Proteins / Q000502:physiology; D006151:Guanosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D009704:Nucleoside Q / Q000502:physiology*; D012343:RNA, Transfer / Q000502:physiology*; D013329:Structure-Activity Relationship; D013872:Thionucleosides / Q000494:pharmacology
D000926:Anticodon; D002352:Carrier Proteins; D013872:Thionucleosides; D006151:Guanosine; C035169:8-bromoguanosine; D009704:Nucleoside Q; D012343:RNA, Transfer; C037031:8-thioguanosine