The stimulations of arachidonic acid metabolism by recombinant murine interleukin 1 and tumor promoters or 1-oleoyl-2-acetyl-glycerol are synergistic.
Recombinant murine IL 1 stimulated arachidonic acid metabolism by rat liver cells (the C-9 cell line) and squirrel monkey smooth muscle cells, and in the presence of tumor promoters this stimulation was synergistic. In the rat liver cells that had been prelabeled with [3H]arachidonic acid, the release of 6-keto-PGF1 alpha and arachidonic acid also was stimulated by the IL 1, and this release was synergistic in the presence of TPA. 1-Oleoyl-2-acetyl-glycerol (OAG) stimulated prostaglandin production, and IL 1 synergized the prostaglandin production in the presence of OAG. OAG and TPA mimic the endogenous activator of protein kinase C, 1,2-diacylglycerol, and therefore IL 1 may amplify arachidonic acid metabolism during signal transmission processes.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002460:Cell Line; D004075:Diglycerides / Q000494:pharmacology*; D015237:Dinoprost; D015232:Dinoprostone; D004357:Drug Synergism; D011464:Epoprostenol / Q000096:biosynthesis; D005989:Glycerides / Q000494:pharmacology*; D007375:Interleukin-1 / Q000494:pharmacology*; D008099:Liver / Q000166:cytology; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D010703:Phorbol Esters / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011994:Recombinant Proteins; D012453:Saimiri
D001095:Arachidonic Acids; D004075:Diglycerides; D005989:Glycerides; D007375:Interleukin-1; D010703:Phorbol Esters; D011458:Prostaglandins E; D011460:Prostaglandins F; D011994:Recombinant Proteins; D016718:Arachidonic Acid; C038237:1-oleoyl-2-acetylglycerol; D015237:Dinoprost; D011464:Epoprostenol; D011493:Protein Kinase C; D015232:Dinoprostone