title: The antibacterial activity of gentamicin in the glucosuric environment.
abstract: The antibacterial activity of gentamicin against 10 isolates of E. coli and 10 of P. aeruginosa was investigated in pooled human urine, with or without the addition of 20 g % dextrose, at pH 6. Mean values for T50 under the influence of 50 mg/ml gentamicin were 3 +/- 0.23 h vs 1.86 +/- 0.10 h and 3.5 +/- 0.08 h vs 1.56 +/- 0.13 h with an osmolality of 1200 mosm/l and 820 mosm/l respectively.
mesh_terms: D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005839:Gentamicins / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D013045:Species Specificity
chemical_list: D003470:Culture Media; D005839:Gentamicins; D005947:Glucose