Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography.
2-Deoxy-2[18F]fluoro-D-glucose positron emission tomography performed in human infants during development revealed progressive changes in local cerebral glucose utilization. In infants 5 weeks of age and younger, glucose utilization was highest in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months. These functional changes measured with positron emission tomography are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000254:growth & development / Q000502:physiology*; D001933:Brain Stem / Q000378:metabolism; D002421:Caudate Nucleus / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D002675:Child, Preschool; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D013788:Thalamus / Q000378:metabolism
D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose