[Importance of the auxotyping of Neisseria gonorrhoeae for evaluating gonorrhea therapy studies].
So far, there was no absolutely reliable way to distinguish between failure and reinfection in clinical trials on the treatment of gonorrhoea. If one, however, analyzes the auxotypes of the gonococcal strains isolated before and after application of the drug from non-cured patients, reinfection can clearly be demonstrated in cases with a changed auxotype. Thus, in a trial on the single intramuscular application of cefotiam 1 g for uncomplicated gonorrhoea, the bacteriological cure rate increased from 90 to at least 95%.
D002986:Clinical Trials as Topic; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D012008:Recurrence
Zur Bedeutung der Auxotypisierung von Neisseria gonorrhoeae für die Auswertung von Gonorrhoe-Therapiestudien.