[Polychlorobiphenyl (Phenoclor DP6) and the metabolism of xenobiotics: effect of a high lipid diet].
Young male rats were fed a balanced diet or a hyperlipidic diet (lard 30%, w/w) for 6 wk. After the first 2 wk each group was divided, one half being maintained as the control and the other half being fed the same diet with a polychlorinated biphenyl (Phénoclor DP6) added at a level of 50 mg/kg diet for 4 wk. In animals fed the balanced diet, DP6 increased the microsomal-protein and cytochrome P-450 content and the specific activity of the monooxygenases. The high-fat diet increased the inductive effect of DP6 on cytochrome P-450, aminopyrine demethylase and benzo[a]pyrene hydroxylase, but not on aniline hydroxylase or cytochrome c reductase.
D000284:Administration, Oral; D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; C013191:phenoclor; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D000815:Aniline Hydroxylase; D001579:Benzopyrene Hydroxylase; D000633:Aminopyrine N-Demethylase; D009245:NADH Dehydrogenase
Polychlorobiphenyle (phenoclor DP6) et metabolisme des xenobiotiques: effets d'un regime hyperlipidique.