title: Blood group variation in the Isle of Lewis.
abstract: Blood groups and protein and enzyme polymorphism distributions were studied in 285 residents on the Isle of Lewis, in the Outer Hebrides. As well as gene frequency calculations for individual loci, genetic distance estimations were made and a phylogenetic tree was constructed. The results indicated several major differences from North-west European populations, with high values of R2(CDe), Rz(CDE) and P1. Among protein and enzyme polymorphisms Hp1, EAPA and PGM1(1) had very high frequencies. Genetic distances show Lewis to be unlike both Western and Eastern North European populations, while the phylogenetic tree shows a common, but rather distant, ancestry with Icelanders. This genetic uniqueness of Lewis as a whole is accompanied by a considerable degree of heterogeneity within the island itself, especially in the ABO and Rh systems. Stornoway, with a greater proportion of residents descended from immigrant stock, shows a greater degree of similarity with neighbouring populations. The reasons for both the overall uniqueness and the heterogeneity within Lewis are discussed, but in the absence of a large time-depth and adequate vital records, the various roles of selection, drift and migration in producing them are difficult to establish.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D001789:Blood Group Antigens / Q000235:genetics*; D001798:Blood Proteins / Q000235:genetics; D004912:Erythrocytes / Q000276:immunology; D005060:Europe; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000235:genetics; D010641:Phenotype; D012204:Rh-Hr Blood-Group System / Q000235:genetics; D012606:Scotland; D006113:United Kingdom
chemical_list: D000017:ABO Blood-Group System; D001789:Blood Group Antigens; D001798:Blood Proteins; D007983:Lewis Blood Group Antigens; D012204:Rh-Hr Blood-Group System