title: What changes can be expected during high frequency jet ventilation when the rate of ventilation, the I:E ratio and the driving pressure are modified? A laboratory study.
abstract: Changes in minute ventilation, tracheal airway pressure and lung volume have been measured using a jet ventilator (VS 600) during different rates of ventilation, I:E ratios and driving pressures. A lung model with a slightly increased compliance and an increased airway resistance was used. Five rates of ventilation (from 60 to 230 b.p.m.), three I:E ratios (0.25, 0.43, 0.67) and three driving pressures (200, 300 and 400 kPa) were studied. The increases in the rate of ventilation did not modify minute ventilation significantly, decreased peak airway pressure only slightly and increased end-expiratory pressure and lung volume. The increases in I:E ratio produced increases in minute ventilation, peak airway pressure, end-expiratory pressure and lung volume. The increases in driving pressure induced changes similar to those produced by the alterations in I:E ratio.
mesh_terms: D000403:Airway Resistance; D005652:Functional Residual Capacity; D006801:Humans; D008170:Lung Compliance; D008954:Models, Biological; D011312:Pressure; D012121:Respiration, Artificial / Q000379:methods*; D012143:Respiratory Physiological Phenomena