Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system.
Na+-dependent binding of 3H-Cocaine is located on dopaminergic terminals and is related to the dopamine uptake system. Studies on senescent rats indicate a decrease in 3H-Cocaine binding density in the striatum. In the same tissue an increase in the Km for dopamine uptake is observed. These changes might be relevant in the age-dependent alterations in dopaminergic function.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D003042:Cocaine / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000378:metabolism
D012965:Sodium Chloride; D003042:Cocaine; D004298:Dopamine