The association of IgG heavy-chain allotypes (Gm) with Graves' disease in Hungary.
In an Eastern Hungarian population of patients, we sought to confirm an association with IgG heavy-chain allotypes (Gm) with Graves' disease. We found an increase in the phenotype fb (chi 2(1) = 4.7, p less than 0.05) among the patient group compared to controls. The influence of Ig-linked genes to Graves' disease susceptibility is, thus, dose-dependent. We found no interaction between fb homozygosity and HLA-DR3 positivity in Graves' disease susceptibility.
D004198:Disease Susceptibility; D005787:Gene Frequency; D005803:Genes, Immunoglobulin; D006111:Graves Disease / Q000235:genetics / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis / Q000235:genetics; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000032:analysis* / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D010641:Phenotype
D006684:HLA-DR Antigens; D007129:Immunoglobulin Gm Allotypes; D007143:Immunoglobulin Heavy Chains