title: Peripheral sympathetic ingrowth can alter metabolic activity within the hippocampal formation.
abstract: After cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers arising from the superior cervical ganglia grow into the dentate gyrus and CA3 region; the functional significance of sympathetic ingrowth into the hippocampal formation is unknown. Utilizing electrical stimulation of the preganglionic trunk in combination with 2-deoxy-D-[3H]-glucose fine-grained autoradiograms, we demonstrated an alteration of hippocampal glucose metabolism, suggesting that this neuronal rearrangement makes functional connections within the hippocampus.
mesh_terms: D000818:Animals; D001345:Autoradiography; D003847:Deoxyglucose / Q000378:metabolism; D004558:Electric Stimulation; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D010525:Peripheral Nerves / Q000254:growth & development*; D051381:Rats; D011919:Rats, Inbred Strains; D012834:Silver; D013564:Sympathetic Nervous System / Q000254:growth & development*; D014316:Tritium
chemical_list: D014316:Tritium; D012834:Silver; D003847:Deoxyglucose