Morphologic changes in the guinea pig cochlea following cochleostomy--a preliminary scanning electron microscope study.
Fistulization of the membranous labyrinth via a surgically created endolymphatic-perilymphatic shunt (cochleosacculotomy) is currently being advocated as a treatment for endolymphatic hydrops. As a preliminary study to the investigation of the effects of labyrinthine fistulization on the hydropic condition, we sought first to reproduce the cochleosacculotomy procedure in a series of normal animals. Fistulization of the cochlear duct was performed in 15 normal animals using a tungsten wire directed via the round window through the cochlear partition in the region of the organ of Corti. The animals were sacrificed at regular intervals and the cochleas examined for histopathologic changes with the scanning electron microscope. Observations suggest that discrete permanent fistulization of the cochlear duct in the normal guinea pig results in progressive sensory cell degeneration. The implication of these observations and the apparent difference between these results and the experience thus far reported in humans are discussed.
D000818:Animals; D001489:Basilar Membrane / Q000648:ultrastructure; D003051:Cochlea / Q000601:surgery / Q000648:ultrastructure*; D003053:Cochlear Duct / Q000648:ultrastructure; D005402:Fistula / Q000473:pathology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D006199:Hair Cells, Auditory, Inner / Q000648:ultrastructure; D007759:Labyrinth Diseases / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000648:ultrastructure; D012405:Round Window, Ear / Q000648:ultrastructure