Thyrotropin-releasing hormone stimulation testing in healthy dogs.
Serum triiodothyronine (T3) and thyroxine (T4) concentrations were determined after IV administration of 200 micrograms of thyrotropin-releasing hormone (TRH) to 10 healthy euthyroid dogs. Significant (P less than 0.05) changes were not found in the T3 concentration throughout an 8-hour sampling interval. All dogs had a significant increase (P less than 0.05) in the T4 concentration at 4, 5, 6, 7, and 8 hours after TRH administration. The largest increase in the serum T4 concentration occurred 4 hours after TRH injection. From 4 to 8 hours after TRH administration, the mean increase above basal T4 concentrations was 13.9 +/- 5.4 ng/ml.
D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D008297:Male; D011863:Radioimmunoassay / Q000662:veterinary; D013960:Thyroid Function Tests / Q000379:methods / Q000662:veterinary*; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine