title: Early decrease in total hemolytic complement activity (CH100) after fasting or intestinal bypass in the rat.
abstract: An evaluation of total hemolytic complement activity (CH100) after fasting or intestinal bypass was performed in rats. The experiment lasted 6 days. Three groups, of 5 animals each, were studied. On the 1st day, basal values of total complement (TC), albumin and body weight were determined. Group A received normal, ad libitum feeding, group B started on a 'water only' diet, group C underwent intestinal bypass. On the 4th and 6th day the parameters were assessed. TC mean values were significantly lower in groups B and C, as compared to group A, on the 4th as well as on the 6th day (p less than 0.01 by Mann-Whitney's U test). Body weight showed a similar trend. Differences in albumin were never statistically significant. Limitations of the analytical method are discussed. The data show that fasting or bypass-induced malabsorption may determine an early decrease in total hemolytic complement activity, though a development of an immune deficiency is not proved.
mesh_terms: D000818:Animals; D001835:Body Weight; D003165:Complement System Proteins / Q000378:metabolism; D005215:Fasting; D005260:Female; D007581:Jejunoileal Bypass / Q000009:adverse effects; D008286:Malabsorption Syndromes / Q000209:etiology / Q000276:immunology; D009748:Nutrition Disorders / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; C048010:complement H100; D003165:Complement System Proteins