Differential roles of raphe nuclei in the regulation of dopamine beta-hydroxylase in the adrenal gland of the rat.
The effect of reserpine on the activity of dopamine beta-hydroxylase (DBH) in the adrenal gland of the rat was determined following electrolytic lesion of the dorsal raphe nucleus (DRN) or medial raphe nucleus (MRN). In sham-operated rats, as well as in those with a lesion of the DRN, there was no significant modification of the action of reserpine on this enzyme. However, a lesion of MRN potentiated the inducing action of the drug. A specific role of MRN in the serotonergic regulation of adrenal DBH is suggested by this work.
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology
D012110:Reserpine; D004299:Dopamine beta-Hydroxylase