title: The need for pilot studies and surgery-only controls in adjuvant therapy trials for large-bowel cancer.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002986:Clinical Trials as Topic / Q000379:methods; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use; D010865:Pilot Projects; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D012107:Research Design
chemical_list: D008937:Mitomycins; D016685:Mitomycin; D005472:Fluorouracil