[Possible regulation of the growth of thyroid tissue by plasma iodide].
Rats on iodine deficient diet for 6 months received propylthiouracil (PTU) (0.15%) during the last 2 months. At the end of this treatment, PTU was withdrawn and the rats were iodine refed. 48 hrs. before the iodine refeeding all rats were injected with 3H thymidine. The results showed that some prelabelled cells in the hyperplastic goitre preferentially disappeared during its involution and therefore are more sensitive to iodine.
D000818:Animals; D006042:Goiter / Q000139:chemically induced; D007454:Iodides / Q000097:blood*; D007455:Iodine / Q000172:deficiency*; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood
D007454:Iodides; D011441:Propylthiouracil; D013972:Thyrotropin; D007455:Iodine; D013936:Thymidine
Régulation possible de la croissance du tissu thyroïdien par l'iodure plasmatique.