[Changes in the lipid levels of the liver, plasma, aorta and cholesterol esterase activity of the rat liver during exposure to tetrachloromethane].
Content of cholesterol esters was increased 2.3-fold, triglycerides--4.7-fold, phospholipids--1.5-fold in liver tissue of CCl4-treated rats. The increase in the content of cholesterol esters and triglycerides correlated with a decrease in activity of lysosomal cholesterol esterase from liver tissue. After CCl4 intoxication content of free cholesterol was decreased 2.1-fold, free fatty acids--2-fold, phospholipids--2.3-fold, triglycerides--1.75-fold in blood. In aorta an increase in content of cholesterol esters and triglycerides was found to be 2-fold as well as activation of the cytosolic cholesterol esterase was noted. The data obtained suggest that intoxication with CCl4 affected the accumulation of cholesterol esters in the arterial wall.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002788:Cholesterol Esters / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D002787:Sterol Esterase / Q000378:metabolism*
D002788:Cholesterol Esters; D008055:Lipids; D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase
Izmenenie soderzhaniia lipidov pecheni, plazmy krovi, aorty i aktivnosti kholesterolésteraz pecheni krysy pri vozdeĭstvii tetrakhlormetana.