Cardiac toxicity of 5-fluorouracil. Report of a case of spontaneous angina.
We report a case of a patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocardiographic evolution was similar to that observed in Prinzmetal's angina, and chest pain promptly resolved with nifedipine. These data suggest that coronary spasm may be the cause of cardiotoxicity due to 5-FU, and that calcium antagonists may probably be used in the prevention or treatment of 5-FU cardiotoxicity.
D000787:Angina Pectoris / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000188:drug therapy; D004562:Electrocardiography; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use
D009543:Nifedipine; D005472:Fluorouracil