[Side effects of postoperative irradiation of uterine cancer with high dose rate iridium and low dose rate radium].
A report is given about reversible and irreversible complications following postoperative irradiation in cases of endometrial carcinoma. Intravaginal brachytherapy was performed. In advanced cases or in cases with poor prognosis (tumor grading) percutaneous irradiation was added (Co60). In 156 cases low-dose-rate irradiation (Ra226) and in 143 cases high-dose-rate irradiation (Ir192) was applied intravaginally. Reversible complications (cystitis, proctitis) could be observed following Radium in 7%, following Iridium in 14%. Irreversible complications (fistulas, stenoses): 1.9% following Radium and 3.5% following Iridium. When high-dose-rate irradiation was combined with percutaneous Co60 therapy, reversible complications occurred in 22.8%. After changing the Iridium-therapy scheme (reduction of dose from 10 to 7 Gy and irradiation only of the upper two thirds of the vagina) complications only could be observed in the same level as in Radium-therapy. High-dose-rate irradiation does not need hospitalization of the patients.
D001918:Brachytherapy / Q000009:adverse effects*; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007495:Iridium / Q000009:adverse effects*; D011867:Radioisotope Teletherapy / Q000009:adverse effects; D011868:Radioisotopes / Q000009:adverse effects; D011879:Radiotherapy Dosage; D011883:Radium / Q000009:adverse effects*; D014594:Uterine Neoplasms / Q000532:radiotherapy* / Q000601:surgery
D003037:Cobalt Radioisotopes; D011868:Radioisotopes; D007495:Iridium; D011883:Radium
Nebenwirkungen der postoperativen High-dose-rate-Iridium- und Low-dose-rate-Radium-Bestrahlung beim Korpuskarzinom.