Secretion of apolipoproteins in the suckling rat. Absence of low-molecular-weight apolipoprotein B of hepatic origin.
Synthesis of apolipoprotein B in the intestine and liver in suckling rats whose duodena had been infused with [3H]lysine was estimated by measuring the radioactivity in the mesenteric lymph and blood serum. Apolipoprotein B synthesized in the suckling rat intestine was an exclusively low-molecular-weight form. In the serum d less than 1.21 g/ml fraction obtained from the lymph-diverted rats, apolipoprotein B of high molecular weight was only labeled with [3H]lysine in suckling rats, whereas both forms of apolipoprotein B were labeled in the adult rats. These results suggest developmental changes in hepatic apolipoprotein B synthesis and secretion.
D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001053:Apolipoproteins / Q000378:metabolism*; D001055:Apolipoproteins B / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D007422:Intestines / Q000032:analysis; D008099:Liver / Q000032:analysis*; D008196:Lymph / Q000032:analysis; D008239:Lysine / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains
D001053:Apolipoproteins; D001055:Apolipoproteins B; D008239:Lysine