[Enhanced effectiveness of antibiotic therapy with an exogenous lysozyme in dysentery in children].
The course of dysentery and the host immune responsiveness were studied in 171 children with acute Flexner's and Sonne dysentery. 67 children were treated with monomycin in combination with lysozyme and 104 children with monomycin alone. It was shown that the recovery period in children treated with monomycin and lysozyme was shorter as compared to that in children treated with monomycin alone. The immunity characteristics in children treated with monomycin were closer to the physiological values. It is concluded that lysozyme potentiates the antibiotic therapy in children with dysentery. It should be used combined with monomycin in the treatment of children irrespective of the age and the disease pattern. The treatment course with the use of monomycin in combination with lysozyme is reduced to 5 days.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004405:Dysentery, Bacillary / Q000188:drug therapy* / Q000276:immunology; D015643:Erythromycin Ethylsuccinate / Q000627:therapeutic use*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007223:Infant; D009113:Muramidase / Q000627:therapeutic use*; D012763:Shigella flexneri; D012764:Shigella sonnei; D013997:Time Factors
D015643:Erythromycin Ethylsuccinate; D009113:Muramidase
Povyshenie éffektivnosti antibiotikoterapii ékzogennym lizotsimom pri dizenterii u deteĭ.