[Effect of Ca2+-ionophore and concanavalin A on potassium permeability and membrane potential of thymocytes].
The existence of Ca2+-dependent K+ channels in rat thymocytes, their activation by Ca2+-ionophore A23187 and concanavalin A, and inhibition by EGTA and quinine have been demonstrated using K+-electrode and fluorescent potential probe diS-C3-(5). The results indicate that Ca2+-dependent K+ channels take part in the increase of potassium permeability, one of the early events in mitogenic stimulation of lymphocytes.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003208:Concanavalin A / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000378:metabolism* / Q000502:physiology
D003208:Concanavalin A; D000001:Calcimycin; D011188:Potassium
Vliianie Ca2+-ionofora i konkanavalina A na kalievuiu pronitsaemost' i membrannyĭ potentsial timotsitov.