Immunoglobulin allotypes are not involved in systemic amyloidosis.
To evaluate the role of immunoglobulin (Ig) allotypes in the pathogenesis of amyloidosis, 8 Gm allotypes and the Km 1 allotype were determined in the sera of patients with amyloid AL (n = 27) and amyloid AA (n = 43). As controls we selected normal individuals (n = 204), 2 patients groups with multiple myeloma (both n = 40) and patients with rheumatoid arthritis (n = 71) and Crohn's disease (n = 47). Our results clearly show that Ig allotypes are not involved in the development of amyloidosis. Our results indicate that the Km 1 allotypic marker is associated with RA.
D000682:Amyloid / Q000235:genetics / Q000378:metabolism; D000686:Amyloidosis / Q000145:classification / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000502:physiology*; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism; D010641:Phenotype; D012107:Research Design; D000685:Serum Amyloid A Protein / Q000235:genetics / Q000378:metabolism
D000682:Amyloid; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D000685:Serum Amyloid A Protein; C035222:amyloid protein AL