Natural antibodies to interferon-alpha and interferon-beta are a common feature of inbred mouse strains.
Neutralizing antibodies to murine interferon-alpha (MuIFN-alpha) and MuIFN-beta of the immunoglobulin (Ig)G and IgM class were naturally present in sera of BALB/c and C57BL/6 mice of four different age groups, ranging from 1 to 15 mo. These antibodies not only neutralized IFN made by C-243 cells (Swiss genotype), but also isogenic IFN-alpha and IFN-beta, and can therefore be considered to be real autoantibodies. Natural anti-MuIFN antibodies were also found in the sera of mice from 12 other inbred strains, and seem to be a common feature of inbred mouse strains.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002846:Chromatography, Affinity; D005260:Female; D005590:Fractional Precipitation; D007106:Immune Sera / Q000032:analysis; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D009500:Neutralization Tests
D000906:Antibodies; D007106:Immune Sera; D007370:Interferon Type I