Protection of guinea pigs against cutaneous leishmaniasis by combined infection and chemotherapy.
A paromomycin and methylbenzethonium chloride ointment cured Leishmania enriettii infections in guinea pigs. Amastigotes were totally eliminated from the treated lesion after 10 days of treatment. A delayed effect also occurred on untreated lesions in the same animals. Lesions treated at various times after infection permitted protective immunity to develop, and 90% of treated animals were refractory to reinfection.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001558:Benzethonium / Q000008:administration & dosage* / Q000031:analogs & derivatives; D004338:Drug Combinations; D006168:Guinea Pigs; D007896:Leishmaniasis / Q000188:drug therapy / Q000276:immunology*; D009824:Ointments; D010303:Paromomycin / Q000008:administration & dosage*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage*; D014611:Vaccination
D000906:Antibodies; D004338:Drug Combinations; D009824:Ointments; D000644:Quaternary Ammonium Compounds; D001558:Benzethonium; D010303:Paromomycin; C005106:methylbenzethonium chloride