Endothelial cell proliferation in myelofibrosis.
The distribution of laminin and collagen type IV in normal human bone marrow appeared to be limited to a small number of capillary and sinusoidal basement membranes. Cellular elements including megakaryocytes showed a negative staining reaction. In contrast, myelofibrotic bone marrow showed markedly increased quantities of both laminin and collagen type IV. This was consistent with a proliferation of endothelial cells within the marrow as confirmed by factor VIII RAG staining. It is suggested that in myelofibrosis in addition to a marked fibrous reaction proliferation of vascular elements is also prominent.
D000941:Antigens / Q000032:analysis; D001853:Bone Marrow / Q000032:analysis / Q000473:pathology*; D002455:Cell Division; D003094:Collagen / Q000032:analysis; D004727:Endothelium / Q000473:pathology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D006801:Humans; D007797:Laminin / Q000032:analysis; D055728:Primary Myelofibrosis / Q000378:metabolism / Q000473:pathology*; D014841:von Willebrand Factor
D000941:Antigens; D007797:Laminin; D014841:von Willebrand Factor; D005169:Factor VIII; D003094:Collagen