Idiopathic premature ovarian failure. A clinical and biochemical study.
Thirty-five black patients with premature ovarian failure were studied. All had normal female karyotypes. Vasomotor symptoms were present in 62% of patients and 60% experienced dyspareunia. Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were raised and circulating oestradiol levels were low in all patients. Ten patients consented to provocative challenge with gonadotrophin-releasing hormone and thyrotrophin-releasing hormone (TRH). After testing, FSH and LH levels were exaggerated in all 10 patients. During TRH administration, thyroid-stimulating hormone levels were within normal limits in 5 patients, elevated in 4 and low in 1. Prolactin responses were raised in 1 patient, subnormal in 1 and within the reference range in 8.
D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause; D008594:Menopause, Premature; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D010908:Pituitary Hormones, Anterior / Q000097:blood*; D011388:Prolactin / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D010906:Pituitary Hormone-Releasing Hormones; D010908:Pituitary Hormones, Anterior; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin