title: The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology; D002470:Cell Survival; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus / Q000378:metabolism; D045647:DNA Glycosylases; D011088:DNA Ligases / Q000502:physiology; D004260:DNA Repair; D004351:Drug Resistance; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D000882:Haplorhini / Q000378:metabolism; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008322:Mammals / Q000378:metabolism*; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008770:Methylnitrosourea / Q000494:pharmacology; D008780:Methyltransferases / Q000502:physiology; D051379:Mice; D009154:Mutation; D009699:N-Glycosyl Hydrolases / Q000502:physiology; D019853:O(6)-Methylguanine-DNA Methyltransferase; D010641:Phenotype; D010920:Placenta / Q000201:enzymology; D051381:Rats
chemical_list: D000477:Alkylating Agents; D001426:Bacterial Proteins; D008769:Methylnitronitrosoguanidine; D006147:Guanine; D008770:Methylnitrosourea; C008449:O-(6)-methylguanine; D008741:Methyl Methanesulfonate; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; C021565:3-methyladenine-DNA glycosylase; D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D011088:DNA Ligases