Increased survival from peritonitis after blockade of transdiaphragmatic absorption of bacteria.
Based upon the knowledge that bacteria in the peritoneal cavity gain access to circulating blood by way of transdiaphragmatic absorption into lymph, a study was carried out to determine whether this absorption protects or endangers the host. Blockade of absorption produced by intraperitoneal (IP) injection of platelet rich plasma (PRP) or by scarification of the peritoneal surface of the diaphragm increased survival time in rats with double colonic perforation from 20 per cent in control rats to 86 and 93 per cent, respectively. Each of these maneuvers significantly increased the number of negative blood culture findings.
D000042:Absorption; D000818:Animals; D018407:Bacterial Physiological Phenomena; D001770:Blood Bactericidal Activity; D001803:Blood Transfusion; D002921:Cicatrix / Q000382:microbiology; D003964:Diaphragm / Q000382:microbiology* / Q000601:surgery; D008196:Lymph / Q000382:microbiology; D008297:Male; D010529:Peritoneal Cavity / Q000382:microbiology; D010538:Peritonitis / Q000382:microbiology / Q000401:mortality / Q000628:therapy*; D017713:Platelet Transfusion; D051381:Rats; D011919:Rats, Inbred Strains