[Embryonal malformation following etretinate therapy of Darier's disease in the mother].
A 22-year-old woman suffering from dyskeratosis follicularis Darier became pregnant 4 months after the last dose of etretinate (Tigason). The pregnancy was terminated in the 10th week because of teratogenic risk. The pathological examination of the fetus revealed severe malformation of the left leg with aplasia of tibia and fibula, as well as hypoplasia of the left femur. This observation emphasises the necessity of effective contraception even after discontinuation of etretinate therapy.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000015:Abnormalities, Multiple / Q000139:chemically induced*; D000032:Abortion, Therapeutic; D000328:Adult; D007644:Darier Disease / Q000188:drug therapy*; D005050:Etretinate / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013723:Teratogens
D013723:Teratogens; D005050:Etretinate
Embryonale Fehlbildung bei Etretinat-Therapie der Mutter wegen Morbus Darier.