Relevance of hyperglycemia to dieldrin toxicity in suckling and adult rats.
Acute exposure to dieldrin (HEOD) causes hyperglycemia and death in the adult rat. Whether the hyperglycemia contributes to the mortality was studied in 10- and 60-day-old Wistar rats given an LD50 dose of the insecticide (pups, 28 mg/kg p.o. and adults, 63 mg/kg p.o.). HEOD elevated blood glucose 2-fold in the adult but had no effect in the pup. d-Glucose (6 g/kg p.o., 0, 3, 6 and 18 h post HEOD) reduced by 79% the 24-h mortality the insecticide caused in the 10-day-old rat. Thus, hyperglycemia in the immature rat protects against dieldrin toxicity. Conversely, the 24-h mortality was not significantly affected in adult rats whose HEOD-induced hyperglycemia was increased with either d-glucose (6 g/kg p.o., every 2 h post HEOD) or 2-deoxyglucose (1 g/kg s.c., concomitant with the HEOD). Phenobarbital (40 mg/kg i.p., concomitant with the insecticide) significantly decreased both the hyperglycemia (23%) and the 24-h mortality (86%) in HEOD-treated adult rats. The administration of d-glucose (6 g/kg p.o., 0, 3, 9 and 18 h post HEOD) to phenobarbital and HEOD-treated animals restored the hyperglycemia and returned the 24-h mortality to that found in animals given dieldrin alone. Thus, in the adult rat HEOD-induced hyperglycemia is a component of dieldrin toxicity.
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D000833:Animals, Suckling; D001786:Blood Glucose; D003847:Deoxyglucose / Q000097:blood; D004026:Dieldrin / Q000633:toxicity*; D004347:Drug Interactions; D005947:Glucose / Q000633:toxicity; D006943:Hyperglycemia / Q000139:chemically induced*; D007928:Lethal Dose 50; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D001786:Blood Glucose; D003847:Deoxyglucose; D004026:Dieldrin; D005947:Glucose; D010634:Phenobarbital