title: Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
abstract: The human interleukin-2 receptor is an inducible growth factor receptor present on the surface of activated T lymphocytes. The receptor is required for a normal T-cell immune response. High-resolution fluorescence-activated chromosome sorting and DNA spot-blot analysis with complementary DNA's for the interleukin-2 receptor indicated that the receptor gene was located on chromosome 9, 10, 11, or 12. In situ hybridization studies showed that the interleukin-2 receptor gene is on the short arm of chromosome 10, p14----15.
mesh_terms: D002460:Cell Line; D002906:Chromosomes, Human, 6-12 and X; D004247:DNA / Q000032:analysis; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D009693:Nucleic Acid Hybridization; D010835:Phytohemagglutinins / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000235:genetics*; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology
chemical_list: D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D004247:DNA