title: Pseudo-precocious puberty associated with mediastinal teratoma and polycystic ovary.
abstract: A 10-month-old girl with sexual precocity of recent onset was found to have elevated levels of estrogens, progesterone and androgen precursors, associated with a polycystic left ovary. After ovariectomy, estrogen and androgen levels were normal, and the clinical symptoms began to regress. A few months later, a huge mediastinal mass was unexpectedly discovered. Removal of the mass, identified later as a benign teratoma, was followed by the total normalization of the clinical and hormonal findings. The patient's pseudo-precocious puberty might have been due to an ovarian overproduction of estroprogestins and androgens, associated with a paraneoplastic production of progesterone, or in theory, it might have been due to a gonadotropin-like stimulation of the ovary by the teratoma.
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood; D008479:Mediastinal Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011374:Progesterone / Q000097:blood; D011629:Puberty, Precocious / Q000209:etiology*; D013724:Teratoma / Q000150:complications*
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone