[Effect of dibasol and several of its imidazo-analogs on the resistance of animals to gravitational overloading and the dynamics of the development of post-ischemic cerebrovascular phenomena].
Anesthetized and nonanesthetized animals (white rats and cats) were used to study the effect of dibasol and its new imidazo analogs (designated AKS-67 and AKS-87) on animal tolerance to gravitational effects and cerebral ischemia (ligation of both carotid arteries) as well as on systemic arterial pressure and tone of cerebral and peripheral vessels (resistographically) in the postischemic period. The drugs were administered 30-90 min before exposure. It was found that in nonanesthetized rats dibasol and AKS-87 increased tolerance to cranio-caudal acceleration and decreased it to caudo-cranial acceleration, whereas AKS-67 produced a distinct protective effect regardless of the vector. In anesthetized rats (bilateral carotid ligation) AKS-67 and AKS-87 increased acceleration tolerance and dibasol produced no protective effect. Dibasol enhanced postischemic hypotension while AKS-67 and AKS-87 delayed or completely arrested it. For aerospace medicine the drug AKS-67 is of particular importance because it increases significantly animal tolerance to acceleration and stabilizes arterial pressure in the postischemic period.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply; D002545:Brain Ischemia / Q000517:prevention & control*; D002415:Cats; D005260:Female; D006112:Gravitation; D006614:Hindlimb / Q000098:blood supply; D002534:Hypoxia, Brain / Q000517:prevention & control*; D008297:Male; D051381:Rats
C048185:AKS 67; C048186:AKS 87; D001562:Benzimidazoles; C004453:bendazole
Vliianie dibazola i nekotorykh ego imidazoanalogov na ustoĭchivost' zhivotnykh k gravitatsionnym peregruzkam i dinamiku razvitiia postishemicheskikh tserebrovaskuliarnykh fenomenov.