[HR 810 (cefpirome). Experimental evaluation of the in vitro and in vivo antibiotic activity of a new amino-2-thiazole methoxy- imino cephalosporin].
HR 810 or cefpirome is a new amino thiazole cephalosporin whose specific characteristic is a cyclopentenopyridinium group in position 3 of the cephem nucleus. This structure is responsible for a broad spectrum of activity, covering Enterobacteriaceae, including cephalosporinase-producing Enterobacter spp. and Citrobacter spp., Staphylococcus aureus, Pseudomonas aeruginosa and group D Streptococci.
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D002954:Citrobacter / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D007710:Klebsiella Infections / Q000188:drug therapy; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012486:Salmonella typhimurium; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome
HR 810 (cefpirome). Evaluation expérimentale de l'activité antibiotique in vitro et in vivo d'une nouvelle amino-2-thiazole méthoxy-imino céphalosporine.