The effects of dietary butylated hydroxytoluene on liver and colon tumor development in mice.
Male and female C3H mice were fed a diet containing 0.5% or 0.05% of the antioxidant butylated hydroxytoluene (BHT). After 10 months, male but not female animals had a significantly increased incidence of liver tumors compared to animals kept on a BHT-free control diet. In a second experiment, male BALB/c mice were treated subcutaneously with the carcinogens dimethylhydrazine (DMH) or intrarectally with methylnitrosourea (MNU). A diet containing 0.5% BHT significantly increased the incidence of colon tumors in DMH treated animals but had no effect in mice given MNU. It is concluded that the effect of BHT on tumor development depends on strain and target organ examined and possibly also on the chemical carcinogen used.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002273:Carcinogens / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004032:Diet; D004127:Dimethylhydrazines / Q000008:administration & dosage; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced; D013997:Time Factors
D002273:Carcinogens; D004127:Dimethylhydrazines; D002084:Butylated Hydroxytoluene; D008770:Methylnitrosourea; D019813:1,2-Dimethylhydrazine