Activated oncogenes in a rat hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline.
The presence of activated oncogenes in several rat hepatocellular carcinomas induced by 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) was examined by NIH 3T3 cell transfection assay and Southern blot analysis. In one tumor, IQ4, rat H-ras-1 and another oncogene that did not belong to the ras family were found to be activated.
D000818:Animals; D002273:Carcinogens; D002478:Cells, Cultured; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D051379:Mice; D009857:Oncogenes; D011804:Quinolines; D051381:Rats; D011916:Rats, Inbred F344; D014162:Transfection
D002273:Carcinogens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline