Aluminum accumulation in individuals with normal renal function.
In individuals with normal renal function, oral aluminum may be absorbed, but the kidneys are able to excrete the load, and significant pathology is not seen. If aluminum is given parenterally, however, it can accumulate in tissues and lead to osteomalacia or aplastic bone lesions. Low calcitriol and PTH levels are often seen, and may contribute to the bone disease. These findings in individuals with normal renal function add to the growing body of evidence that aluminum is toxic to bone.
D000535:Aluminum / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D000818:Animals; D005526:Food, Formulated / Q000009:adverse effects; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism; D010018:Osteomalacia / Q000139:chemically induced*; D010289:Parenteral Nutrition, Total
D000535:Aluminum