title: Cromolyn prevents bronchospastic attacks caused by Bacillus Calmette Geurin immunotherapy for malignant melanoma patient.
abstract: Bacillus Calmette Geurin (BCG) skin immunization is an adjuvant therapy for malignant melanoma patients. Adverse reactions to BCG skin immunization therapy are not uncommon and usually present as fever, influenza-like syndrome, pruritus skin rash, ulcers at the injection site, regional lymphadenopathy, and liver dysfunction. To our knowledge, a bronchospastic BCG immunotherapy-related attack has not yet been reported. We present a case of a patient with malignant melanoma who developed an unusual reaction during BCG immunotherapy. He developed asthma-like attacks after treatment, which could be prevented by inhalation of Cromolyn prior to and after therapy.
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use; D001986:Bronchial Spasm / Q000209:etiology / Q000517:prevention & control*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008297:Male; D008545:Melanoma / Q000628:therapy; D008875:Middle Aged; D012878:Skin Neoplasms / Q000628:therapy
chemical_list: D001500:BCG Vaccine; D004205:Cromolyn Sodium