title: Development of mammalian endocochlear potential: normal ontogeny and effects of anoxia.
abstract: The development of the positive endocochlear potential (EP), the negative anoxic EP, and the organ of Corti potential were measured at various postnatal ages in the Mongolian gerbil, beginning at 8 days after birth (DAB). The organ of Corti potential (OCP) was present at 8 DAB but averaged 21% less than the adult value. OCP increased regularly with age, reaching adult values of -90 mV by 14 DAB. The positive EP was first observed at 10 DAB, at which age it averaged only 2-3 mV. This potential increased monotonically between 10 and 20 DAB, by which time it had reached the adult value of 75 mV. Anoxia did not result in a negative EP until 12 DAB, at which age this potential averaged -7 mV. The negative anoxic EP matured more rapidly than the positive EP, achieving the adult value of 40 mV by 18 DAB. During development the positive EP appeared to closely parallel the maturation of glucose metabolism in the stria vascularis. The negative anoxic EP was more closely related temporally to the development of cochlear microphonic potential (CM) thresholds. It is hypothesized that changes which occur between 10 and 16 DAB in the apical membranes of the cochlear hair cells contribute to the maturation of both CM and the negative anoxic EP.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D003051:Cochlea / Q000254:growth & development* / Q000502:physiology; D004594:Electrophysiology; D004710:Endolymph / Q000502:physiology*; D005849:Gerbillinae; D000860:Hypoxia / Q000503:physiopathology*; D007761:Labyrinthine Fluids / Q000502:physiology*; D009925:Organ of Corti / Q000254:growth & development / Q000502:physiology