Regression of genetically determined polycystic kidney disease in murine organ culture.
Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.
D000818:Animals; D002470:Cell Survival; D003470:Culture Media; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009924:Organ Culture Techniques; D007690:Polycystic Kidney Diseases / Q000235:genetics / Q000473:pathology*; D013997:Time Factors
D003470:Culture Media