title: Pulmonary and systemic consequences of localized acid aspiration.
abstract: Acid aspiration may recruit a generalized inflammatory reaction that can potentiate the local injury. After surgical isolation of bronchi in a group of 15 dogs, 1 milliliter per kilogram of 0.37 normal hydrochloric acid was instilled into either side. After five minutes, platelet and white blood cell counts fell to 10,000 and 1,000 per cubic millimeter (p less than 0.05). Platelet aggregates were noted in blood smears. 111Indium-platelet activity doubled over both the aspirated and nonaspirated lung (p less than 0.05). Physiologic dead space rose from 18 to 67 per cent and to 46 per cent in the aspirated and nonaspirated lung (p less than 0.05). Physiologic shunt increased from 12 to 47 per cent and to 43 per cent (p less than 0.05) on the two sides. Plasma thromboxane B2 levels at 30 minutes rose from 0.28 to 0.93 nanograms per milliliter (p less than 0.05). Edema fluid from the aspirated lung had thromboxane B2 values of 2.87 nanograms per milliliter, indicating pulmonary synthesis. Within five minutes of aspiration, systemic effects were prominent; mean arterial pressure fell from 114 to 46 milliliters of mercury (p less than 0.05), and the cardiac index fell 24 per cent from 106 to 81 milliliters per kilogram per minute (p less than 0.05) along with an 18 per cent decrease in contractility of a rat papillary muscle bathed in plasma from the aspirated dog. Mean pulmonary arterial pressure rose from 12 to 18 millimeters of mercury (p less than 0.05). Despite fluid infusion at 36 milliliters per kilogram per hour to keep wedge pressure constant at 5.5 millimeters of mercury, and sampling of one-third the blood volume, hemoglobin concentration rose 0.9 grams per cent (p less than 0.05) indicating increased microvascular permeability. At autopsy, the aspirated and nonaspirated lung were indistinguishable with congestion, interstitial hemorrhage, and white blood cell infiltrates. Systemic organs showed vascular congestion and edema. These data demonstrate that local aspiration leads to generalized inflammatory sequelae with cardiopulmonary failure.
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006851:Hydrochloric Acid; D000860:Hypoxia / Q000503:physiopathology; D007958:Leukocyte Count / Q000187:drug effects; D008168:Lung / Q000473:pathology; D008176:Lung Volume Measurements; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011015:Pneumonia, Aspiration / Q000097:blood / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D013929:Thromboxane B2; D006851:Hydrochloric Acid