Disposition of nitroglycerin in the beagle dog after intravenous and buccal administration.
The disposition of nitroglycerin was studied in dogs using a crossover design for I.V. (0.85 mg/kg) and buccal (0.75 mg/kg) administration. The pharmacokinetic parameters after I.V. administration are comparable to those in man. The mean values are: t1/2 = 9.2 min; V beta = 3.8 L/kg, Cltot = 238 ml/kg. Similar values were obtained after buccal administration. The bioavailability buccally is 47%. After 7 days pretreatment with nitroglycerin (0.75 mg/kg twice daily, buccally), the area under the I.V. curve (0.85 mg/kg) decreased by about 23%, indicating possible enzyme induction.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D009061:Mouth Mucosa / Q000378:metabolism; D005996:Nitroglycerin / Q000008:administration & dosage / Q000378:metabolism*
D005996:Nitroglycerin