EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia.
With a newly developed system of brain electrical activity mapping we studied 10 right-handed, neuroleptic-treated schizophrenics (five of the disorganized, five of the paranoid type, corresponding to 295.1 and .3 in DSM-III), compared with 10 normal controls. Increasingly complex motor tasks were used for cortical activation, all functional states being referenced to resting states recorded after a special relaxation program. We found higher delta and theta amplitudes during rest, as noted in previous studies, and lower beta power values. As a major result, however, we found a widespread left hemisphere dysfunction in schizophrenics, predominantly in the left primary sensory and motor areas. Additionally, we found signs of a "compensatory" overactivation in patients in motor tasks, when this hemisphere is not "used" by normal persons. The results support our findings obtained with this method during multisensory motor coordination in schizophrenia. The results in these patients suggest that these are not merely vigilance, attention, or motivation dysfunctions, but rather specific cortical correlates of impaired motor performance.
D000208:Acute Disease; D000328:Adult; D000513:Alpha Rhythm; D001143:Arousal / Q000502:physiology; D001611:Beta Rhythm; D003700:Delta Rhythm; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D007092:Imagination / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology; D009048:Motor Skills / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology; D013826:Theta Rhythm