Hypercalcemia associated with increased circulating 1,25 dihydroxyvitamin D in a patient with pulmonary tuberculosis.
Studies are described in a 53-year-old man with far-advanced pulmonary tuberculosis who developed transient increases in circulating 1,25 dihydroxyvitamin D (1,25(OH)2D) and hypercalcemia while on antituberculous treatment. Serial dilution of an extract of the patient's serum obtained while he was hypercalcemic displaced [3H]-1,25(OH)2D3 from chick intestinal receptor in a manner identical to authentic 1,25(OH)2D3. Serum 25-hydroxyvitamin D (25OHD) was suppressed during the abnormal elevation of serum 1,25(OH)2D. It is concluded that tuberculosis is another chronic granulomatous disease in which hypercalcemia may result from abnormal metabolism of vitamin D.
D000818:Animals; D003404:Creatinine / Q000097:blood; D004100:Dihydroxycholecalciferols / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000209:etiology
D004100:Dihydroxycholecalciferols; D010758:Phosphorus; D003404:Creatinine