Gynecomasty: estrogen and androgen receptors. A clinical-pathological investigation.
The histology, estrogen (ER)- and androgen (AR)- receptor content, s-FSH, s-LH, s-17-beta-estradiol, U-17-ketosteroid and U-17-ketogenic steroid patterns were measured in a consecutive series of 20 patients operated on for gynecomasty. Two out of 22 specimens were ER-positive, and 4 out of 22 were AR-positive. No relationship was demonstrated between the histopathologic features, ie. active-intermediate-inactive gynecomasty, and the steroid receptor content in the present limited number of cases. In addition, there was no marked relationship between the histopathologic features and the hormone values.
D015065:17-Hydroxycorticosteroids / Q000032:analysis; D015068:17-Ketosteroids / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D004958:Estradiol / Q000032:analysis; D005640:Follicle Stimulating Hormone / Q000032:analysis; D006177:Gynecomastia / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011944:Receptors, Androgen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone