title: Cyclosporine and experimental renal ischemic injury.
abstract: To investigate the interaction of cyclosporine nephrotoxicity and renal ischemia, an animal model in rats with bilateral renal artery clamping was used. Rats given cyclosporine had a lower rate of recovery from ischemia. However, the percentages of reduction in glomerular filtration rate in vehicle and cyclosporine groups were the same in sham-operated or ischemically treated group. This suggests a superimposition of cyclosporine nephrotoxicity on the recovering kidneys rather than synergistic potentiation between ischemia and cyclosporine nephrotoxicity.
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003524:Cyclosporins / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D004334:Drug Administration Schedule; D007444:Inulin; D007511:Ischemia / Q000401:mortality / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003524:Cyclosporins; D007444:Inulin; D003404:Creatinine