Absorption of 17 beta-estradiol in a neovagina constructed from the peritoneum.
Estrogen absorption from the neovagina was studied by administering 2.0 mg of micronized 17 beta-estradiol (E2) neovaginally to 6 patients. The neovagina in each patient was constructed by using the peritoneum from the pouch of Douglas. A mean peak of circulating E2 concentrations more than 15-times the basal level was achieved 90 min after the application. Until 12.5 h after the application, the E2 levels were significantly (P less than 10(-6)) elevated. FSH levels were significantly (P = 0.003) changed in comparison to the basal serum concentration. There was no significant (P = 0.08) change in LH levels. The resorption of estradiol from the neovagina is similar to that seen in women with normal vaginas.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D010537:Peritoneum / Q000601:surgery*; D013518:Surgery, Plastic; D013577:Syndrome; D013997:Time Factors; D014599:Uterus / Q000002:abnormalities; D014621:Vagina / Q000002:abnormalities* / Q000378:metabolism / Q000601:surgery
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone