Brain angiotensin II and III binding and dipsogenicity in the rabbit.
The rabbit brain evidenced low or non-detectable levels of [125I]angiotensin II binding but considerable [125I]angiotensin III specific binding in agreement with distributions reported for the primate brain. The rabbit was dispsogenically responsive to the intracerebroventricular infusions of angiotensin II and III; however, no elevations in blood pressure were measured for either peptide. Thus, members of this species appear to have limited usefulness as a primate model for central angiotensin-induced cardiovascular changes.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D000805:Angiotensin III / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D004326:Drinking / Q000187:drug effects*; D005849:Gerbillinae; D000882:Haplorhini; D007276:Injections, Intraventricular; D008297:Male; D011817:Rabbits; D051381:Rats
D000804:Angiotensin II; D000805:Angiotensin III