Mechanisms of action of sodium cromoglycate.
The effects of sodium cromoglycate (SCG) on cardiovascular and pulmonary responses to phenylbiguanide, capsaicin, and vagal stimulation were studied in anesthetized guinea pigs. Phenylbiguanide had no bronchospastic activity but induced reflex changes in arterial blood pressure which were reduced or abolished by SCG. Capsaicin induced nonreflex bronchospasm, and decreases in arterial blood pressure that were unaffected by SCG. Sodium cromoglycate, given before or after atropine, had no effect on the bronchospasm and cardiovascular responses to unilateral or bilateral stimulation of the vagus nerves. We conclude that SCG may influence both the afferent and efferent pathways of responses to drugs.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001645:Biguanides / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008170:Lung Compliance / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects
D001645:Biguanides; D001285:Atropine; D004205:Cromolyn Sodium; D002211:Capsaicin; C008846:phenyl biguanide