Tissue plasminogen activator inhibitor in the epidermis.
The presence of a tissue plasminogen activator inhibitor in the epidermis was investigated. A partially purified tissue plasminogen activator from a Bowes melanoma cell line medium was used as a tissue plasminogen activator. Extracts of epidermis dissolved in a 10 mM phosphate buffer, pH 7.0, were found to contain a tissue plasminogen activator inhibitor. The same extracts also contained a urokinase inhibitor. It is not clear whether these inhibitors are the same. This study is the first to show the existence of a tissue plasminogen activator inhibitor in the epidermis.
D000328:Adult; D001798:Blood Proteins / Q000032:analysis; D002460:Cell Line; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D004817:Epidermis / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008545:Melanoma / Q000378:metabolism; D015849:Plasminogen Inactivators; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors*
D001798:Blood Proteins; D006023:Glycoproteins; D015849:Plasminogen Inactivators; C031220:urokinase inhibitor; D010959:Tissue Plasminogen Activator