Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.
Human interferon gamma (HuIFN-gamma) was found to prevent herpes-simplex virus (HSV 1) induced keratitis in monkey eyes, when administered topically at concentrations of greater than or equal to 3 X 10(5) reference units/ml. Protective efficacy demonstrated with lower concentrations of HuIFN-gamma in combination with low titers of HuIFN-alpha provided evidence of synergistic interferon activity in vivo. Tolerance problems observed in eyes affected by virus inoculation seem to be attributable to the experimental conditions including species heterology.
D000818:Animals; D002522:Chlorocebus aethiops; D004274:DNA, Recombinant; D004279:DNA, Viral; D004357:Drug Synergism; D005455:Fluorescent Antibody Technique; D007370:Interferon Type I / Q000235:genetics / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000235:genetics / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000517:prevention & control*
D004274:DNA, Recombinant; D004279:DNA, Viral; D007370:Interferon Type I; D007371:Interferon-gamma