title: Changes in plasma hormone profiles after tumor transplantation into syngeneic and allogeneic rats.
abstract: Transplantation of 2 chemically (DMBA, MCA)-induced tumors into syngeneic female or male DA strain rats elicited hormonal changes during tumor growth. Plasma levels of 7 different hormones were studied. Tumor cells in syngeneic recipients produced a biphasic decrease in insulin, an early increase in prolactin, and a late-phase decrease in thyroxine. Corticosterone decreased in female tumor bearers but increased in males. This difference may reflect differences in the tumors transplanted. Male rats had a decrease in testosterone during the late phase of tumor growth, while females had a biphasic decrease in progesterone and a late-phase increase in growth hormone. The tumors used were moderately immunogenic in syngeneic recipients. However, tumor transplantation to allogeneic recipients produced an early decrease in growth hormone and no change in insulin, corticosterone or thyroxine. Further, transplantation of normal liver cells to syngeneic or allogeneic recipients produced no hormonal abnormalities. This study demonstrates that hormonal changes which are not observed with normal cells or allogeneic tumor transplantation can occur within 2 days of syngeneic tumor transplantation. Progressive tumor growth is characterized by a worsening endocrine imbalance which involves multiple hormone systems.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D003345:Corticosterone / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D008297:Male; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D010908:Pituitary Hormones, Anterior / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D006728:Hormones; D007328:Insulin; D010908:Pituitary Hormones, Anterior; D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D013974:Thyroxine; D003345:Corticosterone