[Effect of an amoxicillin-clavulanic acid combination on the aerobic fecal flora in children].
Counts of aerobic fecal pathogens were done using serial dilutions of stools cultured on selective media with or without amoxicillin + clavulanic acid in 15 hospitalized pediatric patients under oral treatment with the association and in 12 non-hospitalized, non-treated controls. Susceptibility was confirmed by disk antibiotic sensitivity testing. The following microorganisms were studied: Enterobacteriaceae, Pseudomonas, Streptococci D, Staphylococci and Candida. In 8 of the 15 treated patients, Enterobacteriaceae were lacking in one sample or more, but subsequent emergence of resistant Enterobacteriaceae during treatment occurred in 4 of these cases. The 7 other treated patients were immediately colonized by resistant Enterobacteriaceae. No resistant Pseudomonas strains emerged. Streptococci D decreased in some cases. No detectable effect on Staphylococci or Candida was found. Enterobacteriaceae resistant to amoxicillin + clavulanic acid were found in 5 of the 12 controls and in 2 cases accounted for the majority of Enterobacteriaceae.
D000293:Adolescent; D000658:Amoxicillin / Q000494:pharmacology* / Q000627:therapeutic use; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy; D002175:Candida / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D000658:Amoxicillin
Effet de l'association amoxycilline-acide clavulanique sur la flore fécale aérobie de l'enfant.