Senescence does not alter activation or inhibition of striatal adenylate cyclase.
The effects of senescence on the striatal adenylate cyclase system were investigated in 8-10 and 28-30 month old male, CDF(F-344) rats. No difference was observed between the two groups of animals in the activation of adenylate cyclase by dopamine, manganese chloride or sodium fluoride. Similarly, the potency and efficacy of morphine and acetylcholine to inhibit adenylate cyclase activity were not different in the two groups of rats. Thus, the components of the adenylate cyclase system, as well as the coupling of this system to the dopamine, opiate and muscarinic receptors are not changed during senescence.
D000109:Acetylcholine / Q000494:pharmacology; D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000201:enzymology*; D004298:Dopamine / Q000494:pharmacology; D004789:Enzyme Activation; D008297:Male; D009020:Morphine / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344
D000067956:Adenylyl Cyclase Inhibitors; D009020:Morphine; D000262:Adenylyl Cyclases; D000109:Acetylcholine; D004298:Dopamine