Preparation of a short synthetic apurinic oligonucleotide.
The synthesis of the model apurinic oligonucleotide Tp(AP)pT is reported. Furthermore during the course of purification of this compound we have shown that the adduct formed upon reaction with methoxyamine has a Schiff base structure.
D001080:Apurinic Acid / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D006898:Hydroxylamines / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D011119:Polynucleotides / Q000138:chemical synthesis*; D012545:Schiff Bases
D006898:Hydroxylamines; D009838:Oligodeoxyribonucleotides; D011119:Polynucleotides; D012545:Schiff Bases; D001080:Apurinic Acid; C005214:methoxyamine