Clinical usefulness of 111In-oxine-labeled autologous lymphocytes in kidney-graft rejection.
A method of lymphocyte labeling with 111In-oxine was applied for the diagnosis of acute kidney-graft rejection. After the injection of labeled lymphocytes, scintigrams of the graft area, contralateral iliac fossa, and spleen were obtained. Indexes of activity were calculated. No patient without rejection (n = 3) showed lymphocyte graft deposition. Twenty-two patients with acute graft rejection and two patients with on abdominal-wall abscess over the graft area showed lymphocyte graft trapping. When acute graft rejection was present, index i (graft/contralateral iliac fossa) increased, and index c (spleen/graft) decreased. The improvement after the rejection crisis occurred parallel to the decrease in index i. Index c remained unchange regardless of rejection evolution. In summary, 111In-oxine-labeled lymphocytes may be used for the diagnosis of acute kidney-graft rejection and for evolving control.
D006084:Graft Rejection; D006801:Humans; D006912:Hydroxyquinolines; D007204:Indium; D007668:Kidney / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D008214:Lymphocytes; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011877:Radionuclide Imaging
D006912:Hydroxyquinolines; D009942:Organometallic Compounds; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline