title: Relationship between turnover rate and oxidation rate of alanine in the post-absorptive state and during parenteral nutrition before and after surgery.
abstract: The influence of total parenteral nutrition and stomach resection on alanine turnover rate and alanine oxidation rate was measured in ten patients after single injection of U-14 C-alanine. Sequential studies were done in three patients. During parenteral nutrition alanine turnover was significantly higher than in the post-abortive state (14.75 +/- 2.56 mumol kg-1 min-1 and 8.48 +/- 1.88 mumol kg-1 min-1, respectively; P less than 0.01, mean +/- s.d.). Surgery had no additional significant influence on alanine turnover. In the post-absorptive state 4.71 +/- 0.71 mumol kg-1 min-1 was oxidized, during parenteral feeding before surgery 7.93 +/- 1.93 mumol kg-1 min-1 (P less than 0.01 v. post-absorptive state), and during parenteral feeding after surgery 7.67 +/- 1.67 mumol kg-1 min-1. The percentages of alanine turnover used for oxidation in the post-absorptive state and during parenteral feeding before and after surgery were 57 +/- 11%, 54 +/- 7% and 45 +/- 11%, respectively (no significant differences). It is concluded that the degree of alanine oxidation seems to be directed by the degree of alanine turnover. A discussion about differences in alanine oxidation under different circumstances must therefore include a discussion about changes in alanine turnover.
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D000409:Alanine / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010289:Parenteral Nutrition, Total; D013514:Surgical Procedures, Operative
chemical_list: D002245:Carbon Dioxide; D000409:Alanine