Ethanol and heart disease. An underestimated contributing factor.
With the number of chronic heavy users of ethanol in the United States estimated to be 15 to 20 million and the evidence increasing that ethanol causes serious cardiac metabolic disturbances, ethanol abuse is obviously a serious problem and most likely is an important contributing factor to cardiac morbidity and mortality. However, a direct cause-and-effect relationship between the biochemical dysfunctions produced by ethanol and the clinical entity of alcoholic cardiomyopathy has not been clearly established. What is lacking is a method to differentiate the damage secondary to ethanol abuse from that secondary to other causes. Sorely needed is a biochemical or anatomic marker (perhaps evaluated by serial myocardial biopsy) for alcoholic cardiomyopathy and a study to detect which cases of dilated cardiomyopathy indeed are due to ethanol-induced damage. Further longterm studies are also needed to demonstrate the benefits of abstinence upon large groups of patients, the effects of abstinence upon sudden death, and the effects of discontinuance of ethanol use for patients in the early stages of alcoholic cardiomyopathy. Ethanol is probably an underestimated contributing factor to cardiac disease. The importance of determining ethanol's impact on cardiovascular morbidity and mortality is underscored by the facts that alcoholic heart disease is completely avoidable and is largely reversible by abstinence.
D000925:Anticoagulants / Q000627:therapeutic use; D002310:Cardiomyopathy, Alcoholic / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D000431:Ethanol / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008991:Monitoring, Physiologic; D009206:Myocardium / Q000473:pathology; D010808:Physical Examination; D013695:Temperance; D014665:Vasodilator Agents / Q000627:therapeutic use
D000925:Anticoagulants; D002316:Cardiotonic Agents; D004232:Diuretics; D014665:Vasodilator Agents; D000431:Ethanol