Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma.
A segregation analysis was performed on the bronchial response to a standardized methacholine inhalation challenge obtained from members of 83 families that were part of a Natural History of Asthma study population. Each bronchial response was expressed as the area under the best fitting parabolic dose-response curve. Standard methods of statistical analysis demonstrated that age, sex, and recent respiratory infection had a significant effect on the bronchial response to methacholine inhalation. Segregation analysis indicated that, although a familial component exists in the transmission of bronchial response to methacholine, the bimodal distribution of the bronchial response is not due to segregation at a single autosomal locus.
D001249:Asthma / Q000235:genetics*; D001980:Bronchi / Q000187:drug effects; D001985:Bronchial Provocation Tests; D006801:Humans; D008688:Methacholine Compounds; D013223:Statistics as Topic
D008688:Methacholine Compounds