[Effect of ethinyl estradiol sulfonate/norethisterone acetate on TSH, T4, TBC and the FT4 index in pubertal girls].
In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and TRH stimulated TSH secretion, total thyroxine (T4), thyroxine binding capacity (TBC) and free thyroxine index (FT4 index) was investigated. The investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. TSH and T4 serum levels were determined by RIA, TBC by radio agent assay, the FT4 index was calculated. The mean basal TSH levels before, during and after therapy showed no significant differences. During hormonal therapy T4, TBC and FT4 were significant higher (p less than 0.05) than before and after therapy.
D000293:Adolescent; D001120:Arginine; D001827:Body Height / Q000187:drug effects*; D002648:Child; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D010906:Pituitary Hormone-Releasing Hormones; D011627:Puberty / Q000187:drug effects*; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism
D010906:Pituitary Hormone-Releasing Hormones; D013963:Thyroid Hormones; D013975:Thyroxine-Binding Proteins; C025723:ethinyl estradiol sulfonate; D004997:Ethinyl Estradiol; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D001120:Arginine; D000077563:Norethindrone Acetate; D013974:Thyroxine; D009640:Norethindrone
Einfluss von Athinylöstradiolsulfonat/Noräthisteronazetat auf TSH, T4, TBC sowie den FT4-Index bei puberalen Mädchen.