title: Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus.
abstract: The 3' RNA base sequences of several Marburg (MBG) and Ebola (EBO) virus isolates have been determined. A comparison of these 3' terminal noncoding sequences with those of other negative strand RNA viruses suggests a unique phylogenic niche for Marburg and Ebola viruses. The translation initiation site and 35 N-terminal amino acids of the 3' proximal coding gene of a Zaire strain of Ebola virus was predicted. In addition, putative leader RNA sequences preceding the first gene are discussed in terms of possible regulatory functions.
mesh_terms: D001483:Base Sequence; D002213:Capsid / Q000235:genetics; D003062:Codon; D029043:Ebolavirus / Q000145:classification / Q000235:genetics; D005814:Genes, Viral; D029024:Marburgvirus / Q000145:classification / Q000235:genetics*; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000235:genetics*; D012209:Rhabdoviridae / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014758:Viral Core Proteins / Q000235:genetics
chemical_list: D003062:Codon; D012367:RNA, Viral; D014758:Viral Core Proteins