Induction of colony-stimulating factor from quiescent fibroblasts by avian macrophages and monocytic leukemic cells.
Confluent, quiescent chick embryo fibroblasts maintained in protein-free medium released CSF(s) active on granulocyte and monocyte progenitors and on monocytic leukemia cells induced by avian 'myeloblastosis' virus (AMV) when exposed to formaldehyde-fixed AMV leukemic cells. The CSF was assayed under serum-free conditions. Of several normal cell types tested including populations enriched for blast cells, only macrophages exhibited this capacity.
D000818:Animals; D009189:Avian Myeloblastosis Virus; D002478:Cells, Cultured; D002642:Chick Embryo; D002645:Chickens; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D007377:Interleukin-3; D007951:Leukemia, Myeloid / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*
D003115:Colony-Stimulating Factors; D007377:Interleukin-3; D008222:Lymphokines