title: Effect of vasopressin, oxytocin and peptides derived from these hormones on field potential induced in lateral septum of rats by stimulation of the fimbria fornix.
abstract: Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negativity was also observed following superfusion of the septum with [pGlu4, Cyt6] VP(4-9), [pGlu4, Cyt6] VP(4-8), [Cyt6] VP (5-9), desglycinamide9-VP and 1-deamino, 8-D-arginine-VP. However, for obtaining the effect with these peptides 10(3-4) times higher concentrations had to be used. Superfusion of the septum with 10(-8) M oxytocin (OX) elicited nearly the same N-wave increase as the 10(-8) M VP septal superfusion. The 10(-10) M concentration of OX as well as 10(-7) M [pGlu4, Cyt6] OX(4-9) and [pGlu4, Cyt6] OX(4-8) had little effect on the FPs negativity. The significance of these findings for the elucidation of the VP function in the LS is discussed.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology*; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects*; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D010121:Oxytocin / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects*
chemical_list: D010446:Peptide Fragments; D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-; D010121:Oxytocin; C025161:vasopressin, deamino-homo-Arg-; D003894:Deamino Arginine Vasopressin