Non-steroidal anti-inflammatory drugs in combination. Experimental observations.
Diflunisal in combinations with oxaprozin, indomethacin and sodium meclofenamate produced significant synergistic suppression of carrageenan-induced oedema of the rat foot-pad. Oxaprozin, benoxaprofen, indomethacin, diflunisal, sodium meclofenamate and auranofin in some paired combinations but not in others were associated with a greater effect than the component drugs used alone. Antagonism was demonstrated with other combinations of these drugs.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001310:Auranofin; D006051:Aurothioglucose / Q000008:administration & dosage / Q000031:analogs & derivatives; D004061:Diflunisal / Q000008:administration & dosage; D004195:Disease Models, Animal; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004487:Edema / Q000188:drug therapy; D007213:Indomethacin / Q000008:administration & dosage; D008469:Meclofenamic Acid / Q000008:administration & dosage; D000077431:Oxaprozin; D011422:Propionates / Q000008:administration & dosage; D051381:Rats
D000893:Anti-Inflammatory Agents; D011422:Propionates; C011677:benoxaprofen; D006051:Aurothioglucose; D001310:Auranofin; D008469:Meclofenamic Acid; D004061:Diflunisal; D000077431:Oxaprozin; D007213:Indomethacin