title: Ability of base analogs to induce the SOS response: effect of a dam mutation and mismatch repair system.
abstract: 2-Aminopurine, 2-amino-N6-hydroxyadenine, 2-amino-N6-methoxyadenine and 2-amino-N6-methyl-N6-hydroxyadenine (but not N4-hydroxycytidine), strong mutagens of base analog type, may induce the SOS response in E. coli cells. This ability is greatly enhanced in dam3 mutants and abolished in dam3mutS, dam3mutH, and dam3mutL strains, thereby suggesting that the mismatch repair system is involved in the mechanism of induction.
mesh_terms: D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005786:Gene Expression Regulation / Q000187:drug effects; D005798:Genes, Bacterial; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D011401:Promoter Regions, Genetic; D011687:Purines / Q000494:pharmacology*; D014775:Virus Activation / Q000187:drug effects; D001616:beta-Galactosidase / Q000235:genetics
chemical_list: D009153:Mutagens; D011687:Purines; D001616:beta-Galactosidase