title: Spontaneous induction of colicin E1 in Escherichia coli strains deficient in both exonucleases I and V.
abstract: Colicin E1 synthesis is spontaneously induced in pRSF2124-carrying strains of Escherichia coli deficient in exonucleases I (sbcB) and V (recB recC). In contrast, the specific activity of beta-lactamase, which is also encoded by pRSF2124, is not affected by the absence of these enzymes. These results suggest that colicin E1 induction is specific and does not result either from a significant change in overall plasmid transcription or copy number. Furthermore, the level of spontaneous induction was similar to that obtained with mitomycin C.
mesh_terms: D003087:Colicins / Q000096:biosynthesis* / Q000235:genetics; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics; D029968:Escherichia coli Proteins; D043211:Exodeoxyribonuclease V; D005090:Exodeoxyribonucleases / Q000172:deficiency*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D003087:Colicins; D029968:Escherichia coli Proteins; D008937:Mitomycins; D016685:Mitomycin; D005090:Exodeoxyribonucleases; C028450:exodeoxyribonuclease I; D043211:Exodeoxyribonuclease V; C468322:exodeoxyribonuclease V, E coli; D001618:beta-Lactamases