Taste response to 2,5-anhydro-D-hexitols; rigid stereospecificity of the furanose site in the sugar receptor of the flesh fly.
2,5-Anhydro-D-mannitol with a fixed furanose ring stimulated the sugar receptor of the flesh fly and reacted with the furanose site. This is the first direct evidence that a furanose can stimulate the sugar receptor and supports strongly the assumption that beta-D-fructofuranose is the only stimulatory component in the solution of D-fructose. Rigid stereospecificity of the furanose site in the sugar receptor is discussed according to the effectiveness of various synthetic 2,5-anhydro-D-hexitols and related compounds. At least four receptor sites are concluded to be in a single sugar receptor: a pyranose (P) site, a furanose (F) site, an aliphatic carboxylate (R) site and an aromatic amino acid (Ar) site.
D000818:Animals; D002628:Chemoreceptor Cells / Q000187:drug effects*; D002729:Chloromercuribenzoates / Q000494:pharmacology; D004175:Diptera; D005632:Fructose / Q000494:pharmacology*; D008353:Mannitol / Q000031:analogs & derivatives / Q000494:pharmacology; D008968:Molecular Conformation; D013402:Sugar Alcohols / Q000494:pharmacology*; D013649:Taste / Q000502:physiology*; D020245:p-Chloromercuribenzoic Acid
D002729:Chloromercuribenzoates; D013402:Sugar Alcohols; D005632:Fructose; D008353:Mannitol; C031765:2,5-anhydromannitol; D020245:p-Chloromercuribenzoic Acid