[Effects of intravenous administration of chlordesmethyldiazepam on paroxysmal intercritical activity in various electroclinical forms of infantile epilepsy].
24 patients, ages ranging from 6 months to 14.5 years, affected by epilepsy resistant to common antiepileptic drugs were studied. CDDZ was administered intravenously at doses from 0.5 to 2 mg and EEG was recorded for 45 min (15 min before and 30 after drug administration). In 20 patients the EEGraphic paroxystic activity was modified: in 5 cases a total remission and in 2 cases a partial remission were obtained; in 13 cases the EEG alterations were reduced. Myoclonic petit mal and organic focal seizures were the forms of epilepsy showing the best responses to CDDZ administration. The drug was well tolerated and only in two cases was persistent drowsiness observed for more than six hours, possibly due to concomitant barbiturate therapy.
D000293:Adolescent; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000008:administration & dosage; D001569:Benzodiazepines; D002648:Child; D002675:Child, Preschool; D003975:Diazepam / Q000031:analogs & derivatives*; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy*; D004832:Epilepsy, Absence / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D003708:Nordazepam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam
Effetti della somministrazione endovenosa di clordemetildiazepam sull'attività parossistica intercritica in varie forme elettrocliniche di epilessia infantile.