title: Absence of antibody production in patients treated with botulinum A toxin.
abstract: To test the possibility of the formation of an antibody to botulinum A toxin after multiple injections of this potent neurotoxin, we collected serum samples from 28 patients who received 57 doses. These injections over a nine-month period with as much as 50 units per injection formed no detectable antibody.
mesh_terms: D000917:Antibody Formation / Q000187:drug effects*; D001764:Blepharospasm / Q000188:drug therapy / Q000276:immunology; D001905:Botulinum Toxins / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D005152:Facial Muscles; D006801:Humans; D013035:Spasm / Q000188:drug therapy / Q000276:immunology; D013285:Strabismus / Q000188:drug therapy / Q000276:immunology
chemical_list: D001905:Botulinum Toxins