Effect of teleocidin on immune responses in vitro.
The effect of teleocidin, a new tumor promoter, on immune responses was studied in vitro using murine lymphocytes. Teleocidin had a mitogenic and a comitogenic activity on murine lymphocytes at doses of 1-1000 ng/ml. The responder cells to teleocidin stimulation were T cells. However, for the stimulation of T cells with teleocidin, Ia-positive macrophages were required as accessory cells. On the other hand, teleocidin had a suppressive activity at the same doses on the induction of hapten-reactive cytotoxic T cell response in vitro. All these results on mitogenic and immunosuppressive activity are similar to those obtained in a previous study on 12-O-tetradecanoyl phorbol-13-acetate. Thus, it is suggested that the role of tumor promoters during carcinogenesis is a potentiation of the growth of transformed cells and a suppression of the immune-surveillance mechanism.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D008235:Lyngbya Toxins / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects
D002273:Carcinogens; D000949:Histocompatibility Antigens Class II; D008235:Lyngbya Toxins; C022176:teleocidins