Inhibition of the positive atrial chronotropic effect of isoproterenol by exposure to an acrylate floor finish.
Application of a commercial acrylate sealer/finish to the floor of our animal quarters resulted in almost complete elimination of the positive chronotropic response of the hypoxic rat atria to isoproterenol. Forty-eight hours exposure to this sealer/finish decreased sensitivity to isoproterenol by approximately 1000-fold and decreased maximal response by 70%. The elimination of the response to isoproterenol was associated with the resin portion of the sealer/finish and was reversible on removal of the rats from exposure to the product.
D000179:Acrylates / Q000494:pharmacology*; D000818:Animals; D005430:Floors and Floorcoverings; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000179:Acrylates; D007545:Isoproterenol