title: Arterial pH in out-of-hospital cardiac arrest: response time as a determinant of acidosis.
abstract: It is unclear why some victims of out-of-hospital cardiac arrest are severely acidotic on arrival to the emergency department (ED), whereas others have a pH within normal limits. To explain the difference among patients, the authors collected data on 119 consecutive out-of-hospital adult nontraumatic cardiac arrest victims brought to the University of Nebraska Medical Center by paramedic rescue squad between December 1982 and January 1984. Patients who experienced restoration of spontaneous circulation (ROSC) in the field had a normal pH (7.40 +/- 0.13) as compared with the pH of patients still receiving cardiopulmonary resuscitation (CPR) on arrival at the ED (7.18 +/- 0.20). A rapid paramedic response time was the best determinant of ROSC and a normal pH on arrival at the ED. Bystander CPR neither significantly increased the number of patients with ROSC in the field nor protected against the development of acidosis, but did improve the neurological outcome of survivors. The presence of acidosis in patients still receiving CPR on arrival in the ED could not be predicted on the basis of paramedic response time, amount of sodium bicarbonate given in the field, whether or not the collapse was witnessed, or whether or not bystander CPR had been performed. Patients who were acidotic had a significantly higher (P less than 0.001) Paco2 (101 +/- 33 mm Hg) and a lower Pao2 (41 +/- 69 mm Hg) than patients with a normal pH (Paco2 37 +/- 10 mm Hg, Pao2 134 +/- 107 mm Hg). Adequacy of ventilation is the principal determinant of acidosis in patients who are still receiving CPR on arrival at the ED.
mesh_terms: D000138:Acidosis / Q000097:blood*; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood; D004634:Emergency Medical Technicians; D005260:Female; D006323:Heart Arrest / Q000097:blood* / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000592:standards; D012151:Resuscitation; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen