In situ hybridization and translocation breakpoint mapping. II. Two unusual t(21;22) translocations.
Using a combination of banding techniques, we examined two atypical 21;22 translocations, 46,XX or XY,t(21;22)(p11;q11). In situ chromosomal hybridization of a probe for the constant region of the lambda light chain locus demonstrated that the 22q11 breakpoints of both rearrangements were proximal to the C lambda gene cluster. These studies permitted us to distinguish the 22q11 breakpoints of these translocations from the breakpoint of the 22q--chromosome of chronic myelogenous leukemia.
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D005796:Genes; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000235:genetics*; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains