Prognosis of urolithiasis and nephrocalcinosis in hypomagnesemia.
In 78 patients with hypomagnesemia in urolithiasis the clinical course of disease was established in relation to therapy and dynamics of changes of serum magnesium levels. Almost 70% of patients had multiple, bilateral or recurrent nephrolithiasis or nephrocalcinosis. 70% of patients had Ca-oxalate stones or bilateral nephrocalcinosis. In 52% of patients a long-term magnesium supplementation was necessary. Significant progress of nephrolithiasis and nephrocalcinosis was observed in 80% of patients with permanent hypomagnesemia and in 4% of patients with normalization of serum magnesium level. Three of 15 patients with hypomagnesemia and progress of disease were transplanted a kidney and two were treated by hemodialysis. All five patients with renal failure had bilateral nephrocalcinosis, in three of them familiar occurrence of nephrolithiasis and hypomagnesemia was found.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use; D002411:Cation Exchange Resins / Q000627:therapeutic use; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002951:Citrates / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007223:Infant; D007669:Kidney Calculi / Q000209:etiology* / Q000378:metabolism; D016030:Kidney Transplantation; D008275:Magnesium Deficiency / Q000150:complications* / Q000188:drug therapy; D008277:Magnesium Oxide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000188:drug therapy / Q000209:etiology; D010396:Penicillamine / Q000627:therapeutic use; D011379:Prognosis; D011736:Pyridoxine / Q000627:therapeutic use; D006435:Renal Dialysis
D002411:Cation Exchange Resins; D002951:Citrates; D006852:Hydrochlorothiazide; D008277:Magnesium Oxide; D000493:Allopurinol; D002482:Cellulose; C008881:phosphocellulose; D010396:Penicillamine; D011736:Pyridoxine