Alteration of prostanoids in atherosclerosis.
We have briefly summarized only the data obtained in our own laboratory without including an extensive literature review. We have evaluated the changes in platelet membrane phospholipids and prostanoid formation in platelets. In atherosclerosis platelets show an activated prostanoid formation, whereas the plasma PGI2 levels are decreased.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications; D001792:Blood Platelets / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D015237:Dinoprost; D006801:Humans; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D012016:Reference Values; D012710:Serum Albumin, Bovine / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D012710:Serum Albumin, Bovine; D016718:Arachidonic Acid; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost