[Effect of ionol on cytochrome P-450 induction in the liver of rats by polychlorinated biphenyls].
A single oral administration of a mixture of polychlorinated diphenyls (50 and mg/kg) leads to a dose-dependent increase in the cytochrome P-450 content in rat liver. The synthetic antioxidant ionol administered singly and repeatedly (30 mg/kg) does not exert any substantial influence on the hemoprotein content in the liver. Preliminary administration of ionol potentiates the action of the mixture of polychlorinated diphenyls on cytochrome P-450 induction in the liver of experimental animals.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008995:Monoamine Oxidase / Q000096:biosynthesis; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002084:Butylated Hydroxytoluene; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D008995:Monoamine Oxidase
Izuchenie vliianiia ionola na induktsiiu tsitokhroma P-450 v pecheni krys polikhlorirovannymi difenilami.