Triacylglycerol lipase in developing rat sciatic nerve.
Triacylglycerol lipase activity, with a pH optimum of 7.5, was demonstrated in cell-free homogenates of rat sciatic endoneurium. 1,2-Diacylglycerol was the major product of triacylglycerol hydrolysis. A rapid decline in lipase activity was found in rats up to 2 months of age. After this time, the decrease continued, but at a much slower rate. Such developmental changes in triacylglycerol lipase activity may, at least in part, account for the slower metabolic turnover of endoneurial triacylglycerol in adult rat sciatic nerve.
D000818:Animals; D004075:Diglycerides / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008049:Lipase / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000201:enzymology* / Q000254:growth & development
C011439:1,2-diacylglycerol; D004075:Diglycerides; D008049:Lipase