title: Reduction of pathological findings in urine and bladder lesions in infection with Schistosoma haematobium after treatment with praziquantel.
abstract: Egg output, proteinuria, erythrocyturia, and leukocyturia were quantitatively assessed in six schoolchildren with urinary schistosomiasis due to Schistosoma haematobium on 5 days before and 1-35 and 61-65 days after administration of praziquantel (40 mg/kg). Twenty days after therapy, egg output had decreased from a median of 310 before therapy to less than one egg per 10 ml of urine. This decrease was paralleled by a reduction in proteinuria (1.01 g/liter), erythrocyturia (2,142/microliter), and leukocyturia (803/microliter) to normal values. Between days 31-35 and 61-65, five of the six patients had no detectable viable eggs on five consecutive days. Thickening of the bladder wall and vesical polyps detected by ultrasonography returned to a normal appearance one month after treatment. However, dilatation of the renal collecting system showed no significant reduction.
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D010063:Ovum; D011223:Praziquantel / Q000627:therapeutic use*; D012548:Schistosoma haematobium / Q000187:drug effects; D012553:Schistosomiasis haematobia / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D014463:Ultrasonography; D001743:Urinary Bladder / Q000473:pathology*; D014556:Urine / Q000469:parasitology
chemical_list: D011223:Praziquantel