Pre-natal amino acid transport inhibition: long term influences on behavior and protein metabolism.
DBA/2J mice were exposed in utero, between days 15-18 of gestation, to either of two enzyme inhibitors, previously shown to decrease blood-brain, large-neutral amino acid transport in adults: L-methionine-RS-sulfoximine and 2-imidazolidone-4-carboxylic acid. The young mice demonstrated persistently altered motor behavior relative to saline controls when 40-42 days old and evidence of differences in the entry and incorporation of 14C-valine in brain at up to 80 days of age. The findings suggest that interference with blood-brain amino acid transport in utero has long term consequences. This may be related to some human conditions such as maternal phenylketonuria.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001692:Biological Transport / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D048289:Imidazolidines; D008717:Methionine Sulfoximine / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011506:Proteins / Q000378:metabolism*; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D007093:Imidazoles; D048289:Imidazolidines; D011506:Proteins; D008717:Methionine Sulfoximine; C004806:2-imidazolidine-4-carboxylic acid; D014633:Valine