Auxotypes of Neisseria gonorrhoeae in Toronto: relationship to penicillin resistance and to sex of patient.
The relationship of auxotype to penicillinase production, penicillin susceptibility, and sex of the patient, has been studied in 8446 non-penicillinase-producing and 153 penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated during 1980-1983 in Toronto. Proline-requiring types constituted 51% of the PPNG and 13% of the non-PPNG strains; ornithine-requiring types constituted only 4% of the PPNG compared with 12% of the non-PPNG isolates. The various auxotypes of the non-PPNG isolates showed marked differences in their degree of resistance to penicillin; and the proportions of each auxotype from male and female patients were dissimilar.
D002170:Canada; D002956:Citrulline / Q000494:pharmacology; D005260:Female; D006069:Gonorrhea / Q000382:microbiology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000145:classification* / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification / Q000378:metabolism; D009952:Ornithine / Q000494:pharmacology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D011392:Proline / Q000494:pharmacology; D012737:Sex Factors; D014498:Uracil / Q000494:pharmacology
D002956:Citrulline; D014498:Uracil; D011392:Proline; D009952:Ornithine; D010405:Penicillinase