[Treatment of diabetes by implantation of isolated islands of Langerhans in semipermeable chambers].
The biological tolerance of chambers with membranes of regenerated cellulose and the influence of the implantation of isolated islets of Langerhans in these chambers on the blood sugar level of rats with experimental diabetes was investigated. It was concluded that retroperitoneal space offers the best conditions for the implantation of such chambers. The technique of implantation and the preparation of the chambers are the critical factors for the degree of foreign body reaction. The implantation normalized the blood sugar level in rats with an experimental diabetes of a slight degree for a duration of 3 weeks and the glycemia in severe diabetes was soothed for the period of 11 days.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002482:Cellulose; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation; D008567:Membranes, Artificial; D010539:Permeability; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D008567:Membranes, Artificial; D002482:Cellulose
Die Behandlung des Diabetes durch Implantationen von isolierten Langerhansschen Inseln in semipermeablen Kammern.