title: [Modification of the genetic effect of N-nitrosoethylurea in inbred mice by para-aminobenzoic acid].
abstract: The ability of para-aminobenzoic acid--vitamin (PABA) to influence the sensitivity of mice to alkylating mutagens was studied. PABA had no influence on the cytogenetic effect of thio-TEPA. It was determined that PABA altered the effect of N-ethyl nitrosourea (ENU). The direction of modification depends on animal genotype: pre-treatment with PABA decreases the frequency of chromosome aberrations in bone marrow cells of CBA/LacY and C57BL/JY mice, but significantly increases it in 101/HY mice. The PABA influence on the frequency of gene mutations induced by ENU in melanocytes of mice and revealed by "spot-test" was not determined.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000627:therapeutic use*; D062365:Aminobenzoates / Q000627:therapeutic use*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004347:Drug Interactions; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000235:genetics*; D009154:Mutation; D009607:Nitrosourea Compounds / Q000633:toxicity*; D013852:Thiotepa / Q000633:toxicity
chemical_list: D062365:Aminobenzoates; D009607:Nitrosourea Compounds; D013852:Thiotepa; D005038:Ethylnitrosourea; D010129:4-Aminobenzoic Acid
vernacular_title: Modifikatsiia geneticheskogo éffekta N-nitrozoétilmocheviny u inbrednykh mysheĭ para-aminobenzoĭnoĭ kislotoĭ.