[Use of gravitational loads as a screening method in research on new biologically active substances].
The application of longitudinal gravitational overloads in white rats in craniocaudal and caudo-cranial directions modelled on a centrifuge is suggested for the screening of bioactive agents. The time and value of the overload are selected in such a way, as to kill 50% of animals in the control experiments. The same overload is given to animals that have previously received the tested agents. The difference in the survival rate of these animals and the control ones serves as the indicator of activity of the new compounds. This method reflects mainly the functional stability of the system of cerebral circulation.
D000054:Acceleration; D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006112:Gravitation; D051381:Rats
Isplo'zovanie gravitatsionnykh peregruzok v kachestve skriningovoĭ metodiki issledovaniia novykh biologicheski aktivnykh veshchestv.