title: Drug-induced thrombocytopenia.
abstract: A variety of drugs may cause thrombocytopenia. Although it occurs more often than drug-induced anemia it is less well understood because techniques for studying drug-platelet-immune interactions have been unavailable until recently. The mechanisms by which drugs cause thrombocytopenia are varied. Bone marrow suppression or increased peripheral destruction of platelets could be involved. Nonimmunologic as well as immunologic mechanisms may also occur. These different mechanisms of drug-induced thrombocytopenia are reviewed. Diagnostic methods and treatment are also summarized.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology / Q000662:veterinary; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology; D001853:Bone Marrow / Q000187:drug effects; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000276:immunology / Q000662:veterinary; D004285:Dogs; D004342:Drug Hypersensitivity / Q000276:immunology / Q000662:veterinary; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000662:veterinary; D014730:Veterinary Medicine
chemical_list: D004364:Pharmaceutical Preparations