[Isolation and study of the properties of a polyvalent corpuscular Pseudomonas aeruginosa vaccine. An evaluation of the biological properties of a polyvalent corpuscular Pseudomonas aeruginosa vaccine].
P. aeruginosa killed polyvalent corpuscular vaccine, tested in a trial on 42 volunteer donors, is safe, low reactogenic and possesses pronounced immunogenicity, as the injection of the vaccine induced a rise in the titer of antibodies to P. aeruginosa up to 1:1280 in 95% of the immunized donors. To obtain specific antibodies in the blood plasma of the donors in an amount sufficient for the protective activity of the plasma becoming manifest, it is expedient to use the vaccination schedule providing for subcutaneous injections of 0.5, 0.5 and 1.0 ml at intervals of 7 days. Intense immunity thus induced in the donors lasts for 3-4 months. The hyperimmune plasma obtained from the donors has an antibody titer of at least 1:320 and shows a 90-100% protective effect in mice infected intraperitoneally with P. aeruginosa. The preliminary results of the clinical trial of anti-P. aeruginosa plasma have demonstrated its efficiency as a part of the complex treatment of patients with purulent septic complications of P. aeruginosa etiology.
D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000276:immunology / Q000302:isolation & purification*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D051379:Mice; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000276:immunology / Q000517:prevention & control; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007106:Immune Sera; D007136:Immunoglobulins
Poluchenie i izuchenie svoĭstv polivalentnoĭ korpuskuliarnoĭ sinegnoĭnoĭ vaktsiny. Otsenka biologicheskikh svoĭstv polivalentnoĭ korpuskuliarnoĭ sinegnoĭnoĭ vaktsiny.