title: [Effect of glycerol trinitrate on the R amplitude in patients with chronic ischemic heart disease].
abstract: In 46 patients with coronarographically proved stenosing changes of the coronary vessels and typical angina pectoris as well as in 23 patients with coronary system without pathological findings before and after application of 0.8 mg glycerol trinitrate the sum of the R-amplitudes (sigma R) was determined with the help of a precordial mapping system comprising 36 leads. In 10 patients the examinations were repeated after application of an aortocoronary venous bypass. In the coronary patients after glycerol trinitrate a decrease of sigma R was shown. The control group revealed a slight increase of sigma R. The differences between the two groups were statistically significant. After bypass operation the decrease of sigma R under glycerol trinitrate practically disappeared. These results plead with reservation for the thesis that by glycerol trinitrate in coronary patients a reduction of the R-amplitude induced and enlarged by hypoxia may be achieved.
mesh_terms: D000787:Angina Pectoris / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy*; D004562:Electrocardiography; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D005996:Nitroglycerin / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D005996:Nitroglycerin
vernacular_title: Zum Einfluss von Glyzeroltrinitrat auf die R-Amplitude bei Patienten mit chronisch ischämischer Herzkrankheit.