title: Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
abstract: Four histamine antagonists, methapyrilene, thenyldiamine, mepyramine and pyribenzamine were tested for carcinogenicity in rats by continuous application in drinking water. Only methapyrilene displayed significant carcinogenic effects, inducing liver tumors in a dose-related pattern. Analogues not containing a thiophene ring (mepyramine, pyribenzamine) did not exhibit neoplastic effects under the experimental conditions.
mesh_terms: D000236:Adenoma / Q000139:chemically induced; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000631:Aminopyridines; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008701:Methapyrilene; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011725:Pyridines; D011738:Pyrilamine; D051381:Rats; D013329:Structure-Activity Relationship; D014309:Tripelennamine
chemical_list: D000631:Aminopyridines; D011725:Pyridines; D014309:Tripelennamine; D008701:Methapyrilene; C005822:thenyldiamine; D011738:Pyrilamine