[The role of structural heterogeneity of circulating lipids in the regulation of lipoprotein metabolism in the plasma and lymph in hypercholesterolemia in dogs].
Fatty acid spectrum of lipoproteins was studied in intestinal steam lymph and blood plasma of dogs with alimentary hypercholesterolemia. Mechanism of cholesterol accumulation in blood plasma appears to relate to increase in content of cholesterol palmitate which is secreted from intestine into lymph and hydrolyzed slowly in liver tissue. Alterations in composition of fatty acid acyls of cholesterol esters, of phosphatidyl cholines and triacyl glycerides as well as effect of these alterations on the lecithin-cholesterol acyl-transferase reaction and lipoprotein lipolysis are discussed.
D000818:Animals; D002788:Cholesterol Esters / Q000097:blood / Q000378:metabolism; D004036:Diet, Atherogenic; D004285:Dogs; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism; D006937:Hypercholesterolemia / Q000097:blood / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008196:Lymph / Q000378:metabolism*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood; D010713:Phosphatidylcholines / Q000097:blood / Q000378:metabolism
D002788:Cholesterol Esters; D005227:Fatty Acids; D008074:Lipoproteins; D010713:Phosphatidylcholines; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008071:Lipoprotein Lipase
Znachenie strukturnoĭ geterogennosti tsirkuliruiushchikh lipidov v reguliatsii metabolizma lipoproteidov v plazme krovi i limfe v usloviiakh giperkholesterinemii u sobak.