title: [Myelopathy manifesting as macroglobulinemia].
abstract: Slowly progressive cervical cord symptoms over a 2 year period led to the diagnosis of Waldenström macroglobulinemia in a 32 year old man. Diagnosis was made on the finding of circulating monoclonal IgM and lymphocyte infiltration of the bone marrow. Perimedullary infiltration of cervico-dorsal cord was visualized by CT scan. No other tumor tissue was found. Intrathecal secretion of IgM in the CSF was demonstrated. Cervico-dorsal cord radiotherapy followed by systemic chemotherapy led to a rapid improvement in the neurological signs. Reports of spinal cord lesions in Waldenström macroglobulinemia are rare and the relationship of this condition with respect to so-called secreting neurolymphomatosis is discussed.
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000134:cerebrospinal fluid / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid / Q000276:immunology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013118:Spinal Cord Diseases / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy; D014750:Vincristine / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Myélopathie révélatrice d'une macroglobulinémie.