title: [Metabolic interactions of denaverine].
abstract: Owing to enzyme induction, the pretreatment of female Wistar rats with denaverine (Spasmalgan) produces a dose-dependent shortening of the hexobarbital sleeping time, corresponding with an increase in aminophenazon-N- and p-nitroanisol-O-demethylation, cytochrome P-450 concentration and NADPH-cytochrome-c-reductase activity in the 9000 g supernatant of liver homogenates and the relative liver weight, but no change in p-nitrophenetol-O-dealkylation and p-nitrophenol-glucuronidation. Our data suggest that denaverine is a phenobarbital-type microsomal enzyme inducer and justify the expectation of drug interactions in case of repeated application of denaverine in the framework of a combined therapy.
mesh_terms: D000818:Animals; D001561:Benzilates / Q000494:pharmacology*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D008862:Microsomes, Liver / Q000201:enzymology; D008954:Models, Biological; D009251:NADPH-Ferrihemoprotein Reductase / Q000096:biosynthesis; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
chemical_list: D001561:Benzilates; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D009251:NADPH-Ferrihemoprotein Reductase; C001967:denaverine; D010634:Phenobarbital
vernacular_title: Metabolische Wechselwirkungen von Denaverin.