Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treatment of 'autoimmune' disease: a review.
Total lymphoid irradiation (TLI) is a powerful immunosuppressive agent. This immunosuppression has the potential for clinical application in certain selected situations. In this review, the immunological changes produced by TLI and its potential applications in organ transplantation and the treatment of certain 'autoimmune' diseases are discussed.
D000741:Anemia, Aplastic / Q000532:radiotherapy; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000532:radiotherapy; D001327:Autoimmune Diseases / Q000532:radiotherapy*; D016026:Bone Marrow Transplantation; D004285:Dogs; D000882:Haplorhini; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008180:Lupus Erythematosus, Systemic / Q000532:radiotherapy; D008208:Lymphatic System / Q000528:radiation effects*; D009103:Multiple Sclerosis / Q000532:radiotherapy; D009115:Muridae