Vitamin-D-deficient rickets in Manitoba, 1972-84.
Vitamin-D-deficient rickets still exists in children in Manitoba and adjacent areas. Between 1972 and 1984, 48 cases were documented at Winnipeg Children's Hospital. The patients ranged in age from 1 to 49 months; 40 were Canadian natives (38 Indians and 2 Inuit), most of whom lived in the Island Lake area of northern Manitoba. Of the 48, 16 had clinical signs of rickets, 12 had tetany due to hypocalcemia and 38 had radiologic evidence of rickets. Hypocalcemia was found in 27, and hypophosphatemia in 19; hyperaminoaciduria was found in 7 of 20. All 48 had elevated serum alkaline phosphatase levels. In addition to rickets, 16 patients aged 12 months or more had evidence of malnutrition. Climate and lifestyle in northern areas of the Canadian midwest result in little or no biosynthesis of vitamin D by solar radiation; therefore, adequate dietary vitamin D intake is essential to prevent deficiency. The diets of pregnant women and infants in these areas are deficient in vitamin D. The authors recommend vitamin D supplements for all pregnant women and infants in areas of risk to eradicate this preventable disease.
D000596:Amino Acids / Q000652:urine; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000175:diagnosis / Q000453:epidemiology; D007198:Indians, North American; D007223:Infant; D008297:Male; D008350:Manitoba; D009748:Nutrition Disorders / Q000175:diagnosis / Q000453:epidemiology; D010710:Phosphates / Q000097:blood; D012279:Rickets / Q000175:diagnosis / Q000453:epidemiology*; D012621:Seasons; D014808:Vitamin D Deficiency / Q000175:diagnosis / Q000453:epidemiology*
D000596:Amino Acids; D010710:Phosphates