Poly ADP-ribosylation--a cellular emergency reaction?
We propose that the activation of poly(ADP-ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP-ribose). The result is a slow-down of energy-requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP-ribosylated proteins in this reaction beyond their action as acceptors for poly ADP-ribose.
D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004734:Energy Metabolism; D004789:Enzyme Activation / Q000187:drug effects; D009243:NAD / Q000096:biosynthesis / Q000378:metabolism; D009702:Nucleoside Diphosphate Sugars / Q000096:biosynthesis*; D011064:Poly Adenosine Diphosphate Ribose / Q000096:biosynthesis* / Q000502:physiology; D011065:Poly(ADP-ribose) Polymerases / Q000502:physiology
D009702:Nucleoside Diphosphate Sugars; D009243:NAD; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases