title: Chronic perianal herpes simplex in immunocompromised hosts.
abstract: Four immunosuppressed patients are described with chronic ulcerative herpes simplex virus infection in the sacral and perianal area. Three of these patients were evaluated for decubitus ulcers. Prompt diagnosis was possible when the characteristic morphologic features were recognized and when viral culture and Tzanck smear specimens were obtained. Previously reported cases are reviewed as well. Chronic mucocutaneous herpes simplex infections are complications of immunocompromised hosts and should be recognized early if appropriate therapy is to be initiated.
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D001004:Anus Diseases / Q000276:immunology*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000276:immunology; D006561:Herpes Simplex / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012445:Sacrococcygeal Region
chemical_list: D000212:Acyclovir