Calcium-regulating hormones modulate carbonic anhydrase II in the human erythrocyte.
The effect of calcitonin (CT) and parathyroid hormone (PTH) on carbonic anhydrase (carbonate hydrolyase, EC 4.2.1.1.) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II. The most important effect was on carbonic anhydrase II: CT showed a 2-fold increase and PTH showed a 50% decrease of carbonic anhydrase activity. This effect was observed at low hormonal concentrations and suggests the importance of CT in regulating carbonic anhydrase activity in the two important sites of CO2 exchange, erythrocyte and lung.
D002116:Calcitonin / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D007700:Kinetics; D010281:Parathyroid Hormone / Q000494:pharmacology*
D010281:Parathyroid Hormone; D002116:Calcitonin; D002256:Carbonic Anhydrases