[Comparative analysis of the pharmacokinetics of N1-unsubstituted derivatives of 1,4-benzodiazepine].
Parameters of 14C-7-bromo-5-phenyl-1,2-dihydro-3H-1,4-benzodiazepine-2 and its main metabolite distribution in the blood plasma and brain of mice were compared with phenazepam and nordiazepam distribution. Constant ratio of blood plasma 14C-7-bromo-5-phenyl-1,2-dihydro-3A-1,4-benzodiazepine-2, its 3-hydroxy metabolite and other derivatives' level to brain level was noted vs their changing content in the mentioned test objects. Characteristic peculiarities of the distribution of initial 1,4-benzodiazepines and their metabolites and its predictive value are discussed.
D000818:Animals; D001569:Benzodiazepines / Q000032:analysis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D002855:Chromatography, Thin Layer; D005260:Female; D007700:Kinetics; D051379:Mice; D008808:Mice, Inbred CBA; D011485:Protein Binding / Q000187:drug effects; D013997:Time Factors
D001569:Benzodiazepines
Sravnitel'nyĭ analiz farmakokinetiki N1-nezameshchennykh proizvodnykh 1,4-benzodiazepama.