Intraneuronal accumulation of myeloma proteins.
We studied a patient with multiple myeloma who had immunologically identified myeloma light chain proteins within neurons projecting beyond the blood-brain barrier, but not within intrinsic neurons of the spinal cord, brain stem, and cerebral cortex. There was a possibility that these myeloma light chain proteins or their immunologically recognizable fragments were transported intra-axonally by human peripheral nerves. Myeloma light chain proteins were also identified within cerebellar Purkinje's neurons. This labeling may have been secondary to transport from cerebrospinal fluid.
D001369:Axons / Q000378:metabolism; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000032:analysis* / Q000648:ultrastructure; D009194:Myeloma Proteins / Q000032:analysis*; D009474:Neurons / Q000032:analysis* / Q000648:ultrastructure
D007147:Immunoglobulin Light Chains; D009194:Myeloma Proteins