Chlordiazepoxide attenuates response suppression induced by corticotropin-releasing factor in the conflict test.
The role of corticotropin-releasing factor (CRF) in mediating the stress response was studied using a behavioral test in which anxiety or conflict influence performance. Rats implanted with intraventricular cannulae were tested in a Geller-Seifter conflict test modified for incremental shock. CRF produced a dose-dependent attenuation of punished and nonpunished responding in the conflict test. Chlordiazepoxide increased punished, but not unpunished, responding and produced a dose-dependent reversal of CRF-induced response suppression. CRF had no effect on tail flick or hot-plate analgesia tests. The results support the hypothesis that CRF produces behavioral effects consistent with "anxiety" or an increased responsiveness to stress.
D000700:Analgesics; D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D002707:Chlordiazepoxide; D003220:Conflict, Psychological; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*
D000700:Analgesics; D002707:Chlordiazepoxide; D003346:Corticotropin-Releasing Hormone