Bupranolol, a beta 1- and beta 2-blocker, causes constriction of the pupil in men.
Two out of three normal eyes tested with frequent instillation of 30 microliters of drops of 0.5% bupranolol, a beta 1 + beta 2 blocking drug with some intrinsic sympathomimetic and local anesthetic activity, showed a miotic effect of the order of a 25% reduction of pupil area, as estimated by an open-loop iris-videorecorder. A slight contralateral effect was also observed. Blocking by the drug of tonic inhibitory beta-adrenergic activity on the sphincter muscle of the pupil is postulated.
D000320:Adrenergic Fibers / Q000187:drug effects / Q000502:physiology; D000328:Adult; D002046:Bupranolol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008916:Miotics; D009801:Oculomotor Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D011412:Propanolamines / Q000009:adverse effects*; D011680:Pupil / Q000187:drug effects*
D008916:Miotics; D011412:Propanolamines; D002046:Bupranolol