title: Another immune-mediated disease associated with hairy cell leukemia: chronic active hepatitis.
abstract: This report describes a case of hairy cell leukemia (HCL) occurring with autoimmune chronic active hepatitis (CAH). A 74-year-old woman presented with typical clinical and histologic features of HCL for which splenectomy was performed. 2 years later she developed abnormal liver function tests due to auto-immune CAH. The liver function tests improved promptly after prednisolone therapy. HCL has been reported to occur with several immune-mediated diseases including polyarteritis nodosa, rheumatoid arthritis, hemolytic anemia, cutaneous vasculitis and monoclonal gammopathy with amyloidosis. This report adds a further example of HCL coexisting with an immune-mediated disease, in this case autoimmune CAH.
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications*; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications*; D008099:Liver / Q000473:pathology