title: Oral administration of factor VIII concentrate preparation in von Willebrand's disease.
abstract: We investigated on how to effectively administer orally factor VIII preparation to two patients with von Willebrand's disease as volunteers, and the following results were obtained: Bleeding time and aPTT were shortened, but no change of PT was observed. Factor VIII:C increased slightly, but no significant increase was observed in factor VIIIC:Ag. The recovery of factor VIII:C was 19-40%. Factor VIIIR:Ag increased slightly, but no changes of factor VIIIR:RCo were observed. In the Ristocetin induced platelet aggregation (1.5 mg/ml of ristocetin), the collected aggregation abilities were not clear. The factor VIII concentrate preparations, entrapped with liposome, were absorbed from the intestines.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001682:Biological Availability; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D005169:Factor VIII / Q000008:administration & dosage* / Q000032:analysis / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008081:Liposomes / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D014842:von Willebrand Diseases / Q000188:drug therapy*
chemical_list: D001779:Blood Coagulation Factors; D008081:Liposomes; D014677:Pharmaceutical Vehicles; D005169:Factor VIII