[Prediction and prognosis of diabetes incidence in treated hypertensive patients].
The study is based on a clinical population of 1962 hypertensive men and women consecutively examined as in- or out-patients in our clinic from Jan. 1967 to Dec. 1976. Those having a diabetes (treated for diabetes, or fasting glycemia greater than or equal to 7.75 USI) at initial exam were excluded. In february 1977, all were contacted by mail. 89 p. 100 of the subjects still living at the same address answered. 74 "cases" had developed a diabetes (clinical diagnosis, or fasting glycemia greater than or equal to 9.5 USI); they were matched with "controls" according to sex, age (+/- 2), and date of entry (+/- 4 months); all the controls had answered that they were not diabetic in Feb. 1977. At initial exam, the following abnormalities were significantly more pronounced in cases than in controls (by decreasing level of significance): glycemia 1 h. after glucose load, weight index (W/H2), fasting glycemia (p less than 0.001); ECG abnormalities of T (Minnesota code 5.1-3), and J-ST (4.1-3) (p less than 0.01); angina (p less than 0.05). Incidence of diabetes was studied in the basal population, by life table method, according to two abnormalities: relative weight greater than or equal to 115 p. 100, glycemia after load greater than or equal to 8.33. At five years, the estimations were: 0 p. 100 in both sexes, when both abnormalities were absent; 20 p. 100 in men and 31 p. 100 in women when both abnormalities were simultaneously present; 4 p. 100 in men and 2 p. 100 in women in other cases.(ABSTRACT TRUNCATED AT 250 WORDS)
D001581:Benzothiadiazines; D001786:Blood Glucose / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000209:etiology*; D004232:Diuretics; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D009765:Obesity; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects
D001581:Benzothiadiazines; D001786:Blood Glucose; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors
Prédiction et pronostic du diabète incident chez l'hypertendu traité.