Red cell superoxide dismutase is increased in iron deficiency anemia.
Red blood cells (RBC) from iron-deficient rats were found to generate more malonyldialdehyde after in vitro incubation with H2O2 than RBC from control rats (p less than 0.001). The iron-deficient RBC, however, had a higher content of superoxide dismutase (SOD) than control RBC (p less than 0.02). This finding suggests an increased formation of SOD compensatory to an increased oxidant stress.
D000747:Anemia, Hypochromic / Q000097:blood / Q000201:enzymology*; D000818:Animals; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000201:enzymology*; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000166:cytology; D013482:Superoxide Dismutase / Q000097:blood*
D006454:Hemoglobins; D007501:Iron; D013482:Superoxide Dismutase