Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation.
We have observed a differential effect of silybin dihemisuccinate on rat liver microsomal oxygen consumption and on lipid peroxidation induced by NADPH-Fe2+-ADP and t-butyl hydroperoxide. These results are ascribed to the antioxidant properties of the flavonoid. The differences observed in the effect of the catalysts may be a consequence of the different capacity of silybin to act as a scavenger of free radicals formed by NADPH-Fe2+-ADP or t-butyl hydroperoxide.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D005296:Ferrous Compounds / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005609:Free Radicals; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010545:Peroxides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D000077385:Silybin; D012838:Silymarin / Q000031:analogs & derivatives / Q000494:pharmacology*; D020122:tert-Butylhydroperoxide
D005296:Ferrous Compounds; D005419:Flavonoids; D005609:Free Radicals; D008054:Lipid Peroxides; D010545:Peroxides; D012838:Silymarin; D000077385:Silybin; D009249:NADP; D000244:Adenosine Diphosphate; D020122:tert-Butylhydroperoxide; C038266:silybin dihemisuccinate; D007501:Iron; C029451:ferrous chloride