Urinary proteins in a patient with Tangier disease.
We have investigated the possibility that the mild proteinuria in a patient with Tangier disease is directly related to the plasma HDL-deficiency through excretion of apolipoprotein A-I (Mr 28,300). An increased urinary excretion of a 29,000 polypeptide was observed in this patient. However, western blot analysis of the urine showed that this protein was not apolipoprotein A-1 or its precursor form. Subsequent investigations identified the urinary protein as immunoglobulin light chains. The elevated excretion may be a consequence of the patient's plasma polyclonal gammopathy which had resulted from a chronic infection.
D000328:Adult; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000652:urine*; D006801:Humans; D007009:Hypolipoproteinemias / Q000652:urine*; D007147:Immunoglobulin Light Chains / Q000652:urine*; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D013631:Tangier Disease / Q000652:urine*
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D007147:Immunoglobulin Light Chains; D008075:Lipoproteins, HDL