The influence of immunoglobulin on the development of Pseudomonas aeruginosa infection in an immunocompromised mouse model.
Pretreatment with normal immunoglobulin G (normal IgG) isolated from human placental blood, in secondary immune deficiency after anaesthesia, surgery and corticosteroid therapy seems to be an effective protection against bacterial infection in clinical practice. For this purpose, we tried to verify the effectiveness of normal IgG in prevention of bacterial infection in an animal model. The influence of treatment with normal human IgG has been studied in mice exposed to a sublethal infection with Pseudomonas aeruginosa in various states of immunocompetence such as under anaesthesia and corticosteroid therapy. Results, evaluated as percentages of survivors, confirm significant protection against infection with P. aeruginosa despite immunodepression with hydrocortisone and anaesthesia (96.6% of survivors in the group treated with IgG as opposed to 30% for the untreated corresponding group--P less than 0.001).
D000758:Anesthesia; D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000008:administration & dosage*; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology; D051379:Mice; D011552:Pseudomonas Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa
D007074:Immunoglobulin G; D006854:Hydrocortisone