title: Comparison of five methods for the analysis of the light chain type of monoclonal serum IgM proteins.
abstract: Five methods for the analysis of the light chain type of monoclonal IgM proteins present in serum at low concentration were compared in terms of sensitivity, feasibility for use in a clinical laboratory, technical effort required, and cost. These studies indicated that methods based on the removal of IgG from serum were the most appropriate for routine use.
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis*; D002845:Chromatography; D002852:Chromatography, Ion Exchange; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D013205:Staphylococcal Protein A
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D013205:Staphylococcal Protein A