title: Myelin changes in the rats CNS following intraventricular injection of serum.
abstract: Normal human or rat serum administered by intraventricular injection induced demonstrable changes in the rat CNS myelin as seen from an increased recovery of dissociated myelin (DM), i.e. a myelin-related low density membrane fragments, from the tissue homogenates. The yield of DM reached a maximum on the third postinjection day and returned to the control level by day 5. In spite of the increased recovery of DM, no physico-chemical alternations in myelin isolates and no histological abnormalities in the tissue could be detected. The production of DM seems to be a sensitive index of serum-induced alteration of the myelin sheath.
mesh_terms: D000818:Animals; D001769:Blood; D001921:Brain / Q000648:ultrastructure*; D001933:Brain Stem / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009185:Myelin Proteins / Q000032:analysis; D009186:Myelin Sheath / Q000032:analysis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009185:Myelin Proteins