Synergism between gentamicin and mitomycin C in staphylococcal infections in mice.
Mitomycin C, an antineoplastic antibiotic, and gentamicin showed a dose-related protective effect in mice against a lethal staphylococcal infection when used singly. A combination of these two drugs was shown to be synergistic in the mouse model. A specific logistic regression analysis method confirmed that a synergistic bactericidal effect was obtained with the combination.
D000818:Animals; D004357:Drug Synergism; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000401:mortality
D005839:Gentamicins; D008937:Mitomycins; D016685:Mitomycin