title: Effect of subminimal inhibitory concentrations of antibiotics on adherence of Neisseria gonorrhoeae in an experimental model.
abstract: The effect of subminimal inhibitory concentrations (subMICs) of six commonly used antibiotics on adherence of Neisseria gonorrhoeae to rabbit mesentery was studied. We found that, at 1/2 MIC, ampicillin, cefoxitin and penicillin G decreased adherence of gonococci by more than 65%, and erythromycin by approximately 40%; doxycycline and tetracycline had no appreciable effect. Results suggest that subMICs of some antibiotics could affect interactions of gonococci with some mammalian cells, more specifically adherence, a critical step in the pathogenesis of an infection.
mesh_terms: D000268:Adhesiveness; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents