title: Further studies on the ability of different metal salts to influence the DNA synthesis of human lymphoid cells.
abstract: In a further study on the ability of different metal salts to influence the DNA synthesis of human lymphoid cells, aluminum chloride, beryllium chloride, cadmium chloride, cupric sulfate, ferric chloride, manganese chloride, palladium chloride, platinum chloride and silver nitrate, were tested regarding effect on thymocytes and peripheral blood lymphocytes in children. At certain concentrations in the range of 10(-4)-10(-5)M, all tested compounds but aluminum chloride and ferric chloride, were inhibitory, the latter compounds inhibited at 4.8 X 10(-3)M. A slight stimulation mainly on the thymocytes was obtained with beryllium chloride, cadmium chloride, palladium chloride, platinum chloride and silver nitrate, at certain concentrations in the range of 10(-5)-10(-6)M, while ferric chloride gave a slight stimulation at 1.2 X 10(-3)M. Thus, the tested metal salts should be suitable for use in lymphocyte transformation tests for diagnosis of contact allergy.
mesh_terms: D000535:Aluminum / Q000494:pharmacology; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D001608:Beryllium / Q000494:pharmacology; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002712:Chlorides; D003300:Copper / Q000494:pharmacology; D019327:Copper Sulfate; D003877:Dermatitis, Contact / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D008345:Manganese / Q000494:pharmacology; D017895:Manganese Compounds; D008670:Metals / Q000494:pharmacology*; D010165:Palladium / Q000494:pharmacology; D010984:Platinum / Q000494:pharmacology; D017671:Platinum Compounds; D012835:Silver Nitrate / Q000494:pharmacology
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D005290:Ferric Compounds; D017895:Manganese Compounds; D008670:Metals; D017671:Platinum Compounds; D002104:Cadmium; C030173:platinum chloride; D000077410:Aluminum Chloride; D008345:Manganese; D010984:Platinum; C032776:beryllium chloride; D010165:Palladium; D003300:Copper; D012835:Silver Nitrate; D000535:Aluminum; D019256:Cadmium Chloride; D019327:Copper Sulfate; C008756:palladium chloride; D001608:Beryllium; C025340:manganese chloride; C024555:ferric chloride