Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin-ring granulomas.
Hepatic fibrin-ring granulomas were found in a 35-yr-old man who developed fever, myalgias, rash, eosinophilia, and abnormal liver function tests 4 wk after the beginning of allopurinol treatment. All clinical and biochemical abnormalities spontaneously resolved within 6 wk after cessation of therapy. There was no evidence for Q fever or Hodgkin's disease, which are the recognized causes of hepatic fibrin-ring granulomas. It is suggested that allopurinol hypersensitivity might be an additional cause of these peculiar granulomas.
D000328:Adult; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury; D004342:Drug Hypersensitivity / Q000150:complications* / Q000473:pathology; D005337:Fibrin; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology; D008297:Male
D000493:Allopurinol; D005337:Fibrin