[Inhibition of radiation-induced pyknosis of cell nuclei by cadmium ions].
The effect of cadmium chloride (1 to 100 microM) on the frequency of radiation pyknosis, autologous rosette-formation and supercoiled DNA structure was studied in the thymic cells of rats upon gamma-radiation and incubation of cells for 5 h at 37 degrees C. A protective effect of cadmium ions was found at concentrations of 10 to 100 microM and 0.5--4.0 Gy of gamma-radiation, when using pyknotic criterion. Similar effects of Cd2+ were noted in surface receptor assay employing the nucleoid technique. A possible role of cadmium in the inhibition of the interphase death programme is discussed.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D019256:Cadmium Chloride; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002843:Chromatin / Q000187:drug effects / Q000528:radiation effects*; D004278:DNA, Superhelical / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure
D002843:Chromatin; D004278:DNA, Superhelical; D002104:Cadmium; D019256:Cadmium Chloride
Podavlenie radiatsionnogo piknoza kletochnykh iader ionami kadmiia.