title: 2-Aminoethylmethyl-sulfone (AEMS): a potent stimulator of ATP-dependent calcium uptake.
abstract: Retinal ATP-dependent calcium ion uptake is stimulated by a number of agents, but none are previously reported to be as potent as taurine. We have evaluated the effects of 2-aminoethylmethyl-sulfone (AEMS), thiomorpholine-1,1-dioxide (TMS), and N-methyl-thiomorpholine-1,1-dioxide (M-TMS) on calcium ion uptake. AEMS is twice as potent a stimulator of calcium ion uptake compared to taurine. TMS and M-TMS did not stimulate calcium ion uptake at concentrations up to 20 mM. These data demonstrate that the sulfonic acid moiety can be replaced by a methyl sulfone moiety for stimulation of ATP-dependent calcium ion uptake.
mesh_terms: D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D066298:In Vitro Techniques; D008566:Membranes / Q000378:metabolism; D051381:Rats; D012160:Retina / Q000378:metabolism; D013268:Stimulation, Chemical; D013450:Sulfones / Q000494:pharmacology*; D013654:Taurine / Q000494:pharmacology
chemical_list: D002132:Calcium Radioisotopes; D013450:Sulfones; D013654:Taurine; C048130:2-aminoethylmethyl sulfone; D000255:Adenosine Triphosphate; D002118:Calcium