[Comparison between FT-207 and 5-FU on intravesical absorption--experimental study on intravesical absorption in the dog].
FT-207 and 5-FU (1,200 mg) were administered intravesically to 5 mongrel dogs, and their concentration in the serum and bladder wall was measured. The serum concentration was high in both groups because their molecular weights are less than 200. The serum concentration of FT-207 was approximately 40 times higher than that of 5-FU. This difference may be due to the fact that non-ionized molecules in FT-207 account for more than 80% but those in 5-FU account for less than 10%.
D000042:Absorption; D000818:Animals; D004285:Dogs; D005472:Fluorouracil / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D008970:Molecular Weight; D005641:Tegafur / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*
D005641:Tegafur; D005472:Fluorouracil