title: Morphological changes in peripheral blood cells and skin in amiodarone-treated patients.
abstract: Amiodarone, used in the treatment of cardiac arrhythmia, may lead to severe discolouration of sun-exposed skin. The lysosomal storage of a lipid-like material has been shown to be the morphological substrate for this cutaneous hyperpigmentation. Examination of peripheral white blood cells of amiodarone-treated patients disclosed identical lysosomal structures indicating that amiodarone treatment leads to a more generalized lysosomal storage of lipids and of amiodarone and its metabolites.
mesh_terms: D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000648:ultrastructure; D008247:Lysosomes / Q000648:ultrastructure; D008854:Microscopy, Electron; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000473:pathology; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
chemical_list: D001572:Benzofurans; D000638:Amiodarone