title: Effects of apomorphine and haloperidol on "spontaneous" stereotyped licking behaviour in the Cebus monkey.
abstract: Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. Higher doses of apomorphine (0.25-1.0 mg/kg) and haloperidol (0.01-0.1 mg/kg) also decreased or abolished the oral stereotypies, but induced generalized stereotypies (apomorphine) or dystonia/parkinsonism (haloperidol), suppressing normal behaviour. The findings indicate that dopamine is involved in these presumably stress-induced (not drug-induced) stereotypies.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002428:Cebus; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008409:Mastication / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D014059:Tongue
chemical_list: D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine