Reduction of centrally-stimulated gastric acid secretion by tizanidine, a new imidazoline derivative, in anesthetized rats.
The effect of a novel imidazoline derivative (tizanidine) on stimulated gastric acid secretion was studied in the perfused stomach of anesthetized rats. Tizanidine, which did not prevent peripherally-stimulated gastric acid secretion, inhibited 2DG- or TRH-stimulated gastric acid secretion. Yohimbine and phentolamine reduced the inhibition of TRH-stimulated acid secretion by tizanidine. Clonidine was found to have similar effects to tizanidine at a lower dose. These results indicate that tizanidine may inhibit gastric acid secretion via the central alpha-adrenergic system similar to clonidine in anesthetized rats.
D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000037:antagonists & inhibitors; D001626:Bethanechol Compounds / Q000037:antagonists & inhibitors; D003000:Clonidine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003847:Deoxyglucose / Q000037:antagonists & inhibitors; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D010646:Phentolamine / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000037:antagonists & inhibitors
D001626:Bethanechol Compounds; D009125:Muscle Relaxants, Central; D013973:Thyrotropin-Releasing Hormone; C023754:tizanidine; D001285:Atropine; D003847:Deoxyglucose; D003000:Clonidine; D010646:Phentolamine