title: Survival effect of coenzyme Q10 and naloxone on experimental stroke gerbils.
abstract: Coenzyme Q10 (CoQ10) and the opiate antagonist naloxone were compared as to their effect on the survival of mongolian gerbils with unilateral carotid ligation-induced stroke. Without medication all of the stroke gerbils died within 28 hours, but with a subcutaneous implantation of a 10 mg pellet of naloxone, 20% of the gerbils lived for 4 weeks. When a 250 mg pellet of CoQ10 was implanted subcutaneously, a definite effect on survival was observed, with 45% of the stroke gerbils living for 4 weeks. Considering that the action mechanisms of CoQ10 and naloxone are different, the combined use of these drugs in the treatment of stroke needs to be investigated.
mesh_terms: D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000378:metabolism; D003067:Coenzymes; D004579:Electron Transport / Q000187:drug effects; D005849:Gerbillinae; D007977:Levallorphan / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; D007977:Levallorphan; D009270:Naloxone; C024989:coenzyme Q10