Specific plasma cell accumulation in antigen-induced chronic inflammation in the guinea pig peritoneal cavity.
Specificity of plasmacellular infiltration was studied using a guinea pig peritoneal inflammation model. Acute and chronic inflammations were induced by repeated injections of either of two non-crossreacting antigens (DNP-BSA and PPD). With an enzyme-immunohistochemical sandwich procedure allowing quantitation of DNP-BSA-specific plasma cells, specificity of plasmacellular infiltration could be demonstrated. DNP-BSA-specific antibody-forming cells were found not to enter inflammatory reactions elicited by PPD. Our data support the hypothesis that virtually all plasma cells in a chronic inflammatory exudate release antibodies specific for antigens that are locally available, and that such antigens are likely to play a central role in the perpetuation of chronicity.
D000818:Animals; D000918:Antibody Specificity; D000921:Antibody-Producing Cells / Q000276:immunology*; D002465:Cell Movement; D002908:Chronic Disease; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007249:Inflammation / Q000276:immunology*; D010529:Peritoneal Cavity / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology*; D012710:Serum Albumin, Bovine / Q000276:immunology; D014373:Tuberculin / Q000276:immunology
D004136:Dinitrobenzenes; D014373:Tuberculin; D012710:Serum Albumin, Bovine