The ferritin content of normoblasts and megaloblasts from human bone marrow.
Erythroblasts were enriched from human bone marrow samples and fractionated on Percoll gradients according to maturity. Heart-type and spleen-type ferritin was measured in each fraction by an immunoradiometric assay. In normal marrow, heart-type ferritin content was higher in the early erythroblast fractions and fell with maturation. Spleen-type ferritin content showed no such consistent change. Megaloblastic erythroblasts had a significantly higher ferritin content.
D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D002452:Cell Count; D002499:Centrifugation, Density Gradient; D004900:Erythroblasts / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005293:Ferritins / Q000032:analysis*; D006801:Humans; D011863:Radioimmunoassay
D005293:Ferritins