[Dynamics of the immunodepressive and antitumor activity of adriamycin].
It was revealed in experiments on mice that the immunodepressive activity of adriamycin depends exponentially on the dose of the preparation and is marked both before and after the antigen stimulation. The degree of immunodepression, the kinetics of formation and attenuation of the immune response depend on the dose of adriamycin. The preparation possesses antitumoral activity in relation to the plasmacytoma MOPC-315.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D004306:Dose-Response Relationship, Immunologic; D004317:Doxorubicin / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D007114:Immunization; D007166:Immunosuppressive Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000188:drug therapy / Q000276:immunology; D013997:Time Factors
D007166:Immunosuppressive Agents; D004317:Doxorubicin
Dinamika immunodepressivnoĭ i protivoopukholevoĭ aktivnosti adriamitsina.