Sensitization of rotational behavior produced by a single exposure to cocaine.
In rats with a unilateral 6-OHDA lesion of the substantia nigra a single exposure to cocaine significantly enhanced the ipsiversive rotational behavior produced by a second injection given one week later. It is concluded that it is not necessary to repeatedly administer psychomotor stimulant drugs to produce long-lasting changes in brain and behavior.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine; D051381:Rats; D012399:Rotation; D013268:Stimulation, Chemical; D013378:Substantia Nigra / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine; D003042:Cocaine