Blood pressure and metabolic effects of 9 alpha-fluorocorticosterone and 9 alpha-fluorodeoxycorticosterone in sheep.
9 alpha-Fluorocortisol has been postulated to have 'hypertensinogenic' as well as 'mineralocorticoid' and 'glucocorticoid' activity. The present study examined the blood pressure and metabolic effect in sheep of the structurally related steroids 9 alpha-fluorodeoxycorticosterone (9 alpha-FDOC) and 9 alpha-fluorocorticosterone (9 alpha-FB). Infusions of these fluorinated steroids at 0.63 and 0.67 mg/day respectively for 5 days produced falls in plasma potassium, but only 9 alpha-FB increased urine volume. 9 alpha-FDOC raised mean arterial pressure by 11 mmHg and 9 alpha-FB raised it by 14 mmHg. Addition of a 9 alpha-fluoro group appears to increase both 'mineralocorticoid' and 'hypertensinogenic' steroid potencies.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D011188:Potassium / Q000097:blood* / Q000652:urine; D012756:Sheep
C044438:9 alpha-fluorocorticosterone; C044437:9-fluorodeoxycorticosterone; D003900:Desoxycorticosterone; D011188:Potassium; D003345:Corticosterone