Hypercholesterolaemia accentuates platelet activity.
Platelet aggregation response to collagen has been studied in 20 rabbits, randomly allocated to receive a normal (control) or high cholesterol diet. The sensitivity of platelets to collagen was significantly higher in the hypercholesterolaemic group (p less than 0.01) compared to controls. All hypercholesterolaemic rabbits developed generalised atherosclerosis and this may be due to increased circulating platelet activity.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003094:Collagen / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D014280:Triglycerides; D003094:Collagen