Idiopathic post-operative pulmonary hypertension in the newborn.
A case of severe pulmonary hypertension following the primary repair of an omphalocele in a term infant is reported. There were no pre-disposing factors known to contribute to the postoperative pulmonary hypertension (PPH). Therapy was successful first by using hyperventilation, and then subsequently with tolazoline. Upper gastrointestinal bleeding limited the use of tolazoline after the first fourty-eight hours. Complete recovery ensued. The occurrence of PPH and the current therapy of this unpredictable condition is discussed.
D002245:Carbon Dioxide / Q000097:blood; D003131:Combined Modality Therapy; D004562:Electrocardiography; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006439:Hemodynamics / Q000187:drug effects; D006554:Hernia, Umbilical / Q000151:congenital / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications / Q000209:etiology; D012121:Respiration, Artificial; D014043:Tolazoline / Q000009:adverse effects / Q000627:therapeutic use
D002245:Carbon Dioxide; D014043:Tolazoline; D010100:Oxygen