Increase of oleic acid in erythrocytes associated with malignancies.
Total lipid extracts of erythrocyte cell membranes from 60 patients with documented malignancies, 41 patients with various acute and chronic diseases, and 40 healthy subjects were analysed. The results were expressed as ratios of stearic to oleic acid, reflecting the degree of desaturation of stearic acid. The mean ratios for the healthy subjects and controls without cancer were 1.5 (SD 0.27) and 1.45 (0.28), respectively, whereas the ratios for patients with malignancies were consistently lower than the cut off point of 1.0, with a mean of 0.69 (0.15) (p less than 0.001). The desaturation ratio was also significantly lower (p less than 0.001) in the group with recurrent tumours (mean 0.75 (0.04)) compared with those with no evidence of recurrent tumours (mean 1.55 (0.27)). It is suggested that the increased unsaturation (oleic acid) in the circulating erythrocytes may be useful in the diagnosis and postoperative monitoring of patients with cancer.
D004910:Erythrocyte Membrane / Q000032:analysis*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood; D009369:Neoplasms / Q000097:blood*; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood*; D013229:Stearic Acids / Q000097:blood
D009829:Oleic Acids; D013229:Stearic Acids; D019301:Oleic Acid; C031183:stearic acid