An idiopathic factor VIII anticoagulant: resolution following plasmapheresis and cytotoxic therapy.
A case is described in which plasmapheresis and immunosuppressive therapy were employed to treat a patient with a spontaneously occurring idiopathic polyclonal immunoglobulin G factor VIII anticoagulant. The favorable response observed supports the usefulness of the described treatment methods for the acute and chronic management of acquired circulating factor VIII inhibitors.
D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000276:immunology / Q000628:therapy*; D001803:Blood Transfusion; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005169:Factor VIII / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D008875:Middle Aged; D010956:Plasmapheresis; D011241:Prednisone / Q000627:therapeutic use*
D007136:Immunoglobulins; C019158:circulating anticoagulants; D003520:Cyclophosphamide; D005169:Factor VIII; D011241:Prednisone