title: Pharmacokinetics of cefotaxime in the domestic cat.
abstract: Cefotaxime was administered as single IV or IM dose for the purpose of examining its pharmacokinetics in healthy cats. The mean predicted plasma concentration of cefotaxime in 6 cats at 0 time after a single IV dosage of 10 mg/kg of body weight was 88.9 micrograms/ml. The mean plasma concentrations decreased to 10.8 micrograms/ml at 2 hours, 3.7 micrograms/ml at 3 hours, and 0.5 microgram/ml at 6 hours. The half-life was 0.98 +/- 0.25 hour (mean +/- SD), and the total body clearance was determined to be 2.76 +/- 1.25 ml/min/kg. After a single IM injection of 10 mg/kg of body weight, the mean maximum observed plasma concentration was 36.2 micrograms/ml at 0.75 hour. The mean absorption half-life was 0.24 hour. In 2 animals, the bioavailability of an IM injection was 98.2% and 93.0%.
mesh_terms: D000818:Animals; D002415:Cats; D002439:Cefotaxime / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics
chemical_list: D002439:Cefotaxime