The role of noradrenaline in tuning and dopamine in switching between signals in the CNS.
Neuronal catecholaminergic activity modulates central nervous function. Specifically noradrenaline can exert a tuning or biassing function whereby the signal to noise ratio is altered. Dopamine activity may promote switching between inputs and outputs of information to specific brain regions. It has been ten years since evidence for a tuning function was advanced for noradrenaline and in the last 5 years the switching hypothesis for dopamine has been tentatively put forward. Recent studies are reviewed to show that while catecholamine activity contributes to neural interactions in separate brain regions that give rise to the organization of different functions, their working principles may be common between species and independent of the nucleus of origin. Behavioral examples are discussed and an attempt is made to integrate this with evidence from intracellular recording studies. It is suggested that the tuning principle in noradrenergic systems is particularly important for the formation of associations and neural plasticity (interference control) and that the switching principle of dopaminergic systems modulates the timing, time-sharing and initiation of responses (program-control).
D000320:Adrenergic Fibers / Q000502:physiology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001143:Arousal / Q000502:physiology; D001288:Attention / Q000502:physiology; D001921:Brain / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology; D007858:Learning / Q000502:physiology*; D008032:Limbic System / Q000502:physiology; D008568:Memory / Q000502:physiology; D009042:Motivation / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology*; D016627:Oxidopamine; D011603:Psychophysiology / Q000379:methods; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology
D006892:Hydroxydopamines; D016627:Oxidopamine; D000661:Amphetamine; D004298:Dopamine; D009638:Norepinephrine