Hyperinnervation of the striatum by dorsal raphe afferents after dopamine-depleting brain lesions in neonatal rats.
Dopamine-depleting brain lesions produced in neonatal rats by intraventricular injection of 6-hydroxydopamine (6-OHDA) are known to increase striatal levels of serotonin by adulthood. We now report that such lesions lead to an increased innervation of the striatum by serotonin-containing neurons from the dorsal raphe nucleus. This hyperinnervation was revealed as a 300% increase in the number of retrogradely labeled neurons in the dorsal raphe after horseradish peroxidase was injected into the adult striatum. The degree of hyperinnervation was reduced sharply when serotonin-depleting brain lesions were given to adult animals that had received 6-OHDA as neonates.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D006735:Horseradish Peroxidase; D006892:Hydroxydopamines / Q000494:pharmacology*; D016627:Oxidopamine; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism
D006892:Hydroxydopamines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D016627:Oxidopamine; D006735:Horseradish Peroxidase; D004298:Dopamine