[Role of emotions in cholinergic mechanisms of formation and reproduction of a bilateral conditioned avoidance reflex].
In experiments on rats it was shown that during elaboration of a bilateral avoidance conditioned reflex against scopolamine background, facilitation of the learning process takes place only at simultaneous elimination of the emotional fear reaction expressed in a decrease of the heart-rate. The presence of non-cholinergic mechanisms participating in generation of high-frequency (8-12 c/s) hippocampal regular activity is necessary for the reproduction of instrumental avoidance reaction against the scopolamine background. A resistivity of emotional fear reaction to cholinoblocators in animals learning with difficulty, is revealed (monitored according to conditioned decreasing of the heart-rates). This fact points to the non-cholinergic nature of a definite type of emotional passive fear reaction. The theory of memory dissociation explains the inversely-proportional dependence of the reflex stability after cancelling of scopolamine administration upon the duration of reaction stabilization against the background of the drug.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004562:Electrocardiography; D004569:Electroencephalography; D004597:Electroshock; D004644:Emotions / Q000502:physiology*; D010115:Oxyphenonium / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology*; D012601:Scopolamine; D013016:Sound
D010276:Parasympatholytics; D011976:Receptors, Muscarinic; D010115:Oxyphenonium; D012601:Scopolamine
Rol' émotsiĭ v kholinergicheskikh mekhanizmakh formirovaniia i vosproizvedeniia uslovnogo refleksa dvustoronnego izbeganiia.