title: Gentamicin dosage recommendations for neonates based on half-life predictions from birthweight.
abstract: The appropriate dosing of gentamicin in the newborn was evaluated. Gentamicin was administered intramuscularly to 151 neonates ranging in birthweight from 0.66 to 4.7 kg (gestational age, 26-42 weeks) during a 7-month period. A dosage of 2.5 mg/kg of birthweight every 12 hours was initiated at birth until gentamicin serum levels could be determined. These infants were divided into three groups based on birthweight: 1) less than or equal to 1000 gm; 2) 1001-2000 gm; 3) greater than 2000 gm. From gentamicin serum level data, these three groups had significantly different (P less than 0.05) gentamicin half-lives. Based on the desirability of maintaining a trough gentamicin serum level less than 2, 100, 95.5, and 39% of infants in groups 1, 2, and 3, respectively, required initial dosing interval adjustments. A second group of 74 infants whose birthweight ranged from 0.82 to 3.9 kg (gestational age, 26-42 weeks) required aminoglycoside therapy and were prospectively placed on gentamicin 2.5 mg/kg of birthweight on the following schedule: 1) less than or equal to 1000 gm every 24 hours; 2) 1001-2000 gm every 18 hours; 3) greater than 2000 gm every 12 hours. Using this method, only 15, 58, and 33% of infants in groups 1, 2, and 3, respectively, required dosing interval changes. We conclude that a marked reduction in undesirably high trough gentamicin serum levels can be affected by a simple change in dosing interval based on birthweight, although gentamicin serum levels are still required due to a significant number of infants with high trough levels.
mesh_terms: D001424:Bacterial Infections / Q000188:drug therapy*; D001724:Birth Weight; D004334:Drug Administration Schedule; D005839:Gentamicins / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006090:Gram-Negative Bacteria; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D005839:Gentamicins