title: Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation.
abstract: Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.
mesh_terms: D000483:Alleles; D002648:Child; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D010641:Phenotype; D011110:Polymorphism, Genetic; D011519:Proto-Oncogenes; D012509:Sarcoma / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D004273:DNA, Neoplasm