The absorption of doxorubicin and mitomycin C in perioperative instillation. An experimental and clinical study.
Neither doxorubicin (ADM) nor mitomycin C (MMC) were well absorbed through the intact or damaged rabbit bladder wall into the blood stream. Preliminary clinical investigations indicating negligible systemic side effects of ADM and MMC agree with the experimental results.
D000042:Absorption; D000368:Aged; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism* / Q000627:therapeutic use; D004317:Doxorubicin / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000378:metabolism* / Q000627:therapeutic use; D011817:Rabbits; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin