Immunological studies on the origin of the precursor cells in Waldenström's macroglobulinemia.
Preliminary results obtained with OK anti-T and FMC anti-B monoclonal antibodies in a study of peripheral blood lymphocytes from eight patients with Waldenström's macroglobulinemia and of bone marrow lymphocytes from three patients, are reported. Endocytoplasmic immunofluorescence revealed a 1 to 3% marrow plasma cell fraction in all three cases, together with an approximately 10% increase in the monoclonal precursor compartment. Displacement of the peripheral blood helper: suppressor ratio was also observed using anti-T-lymphocyte monoclonal antibodies.
D006801:Humans; D008214:Lymphocytes / Q000145:classification; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013154:Spleen / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology* / Q000473:pathology
D011947:Receptors, Antigen, B-Cell