[Activation of cholesterogenesis in response to ionizing irradiation of the animal body].
The assumption is made that ionizing radiation induces cholesterogenesis activation in different cells of mammalian organism as an early reaction to the harmful effect necessary for restoration of biomembranes. Liver cells activate adaptively the cholesterol synthesis in the animal body irradiated with lethal doses in response to the injury to radiosensitive cells in order to make them recover and compensate for their functions (with the gastrointestinal syndrome, for instance, to compensate for the cholesterol-producing function of the intestine and to make it recover). With lethal radiation doses, a change in the lipid content and metabolism of microsomal membrane lipids of the liver is associated with activation of synthetic functions of the liver due to compensation of the injury to radiosensitive tissues.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D008099:Liver / Q000528:radiation effects; D008563:Membrane Lipids / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats
D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D002784:Cholesterol
Ob aktivatsii kholesterogeneza pri vozdeĭstvii ioniziruiushcheĭ radiatsii na zhivotnyĭ organizm.