Amyloidosis localized to the lower respiratory tract: probable immunoamyloid nature of the tracheobronchial and nodular pulmonary forms.
Seven patients with localized nodular pulmonary amyloidosis and four with tracheobronchial amyloidosis are presented and the pathological features described. The congophilia of these forms of amyloid is resistant to potassium permanganate, compatible with it representing immunoamyloid. This, together with the associated intense lymphocytic and plasma cell infiltration suggests a local inflammatory aetiology.
D000328:Adult; D000682:Amyloid / Q000145:classification / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D001982:Bronchial Diseases / Q000378:metabolism; D003224:Congo Red; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D008171:Lung Diseases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012140:Respiratory Tract Diseases / Q000378:metabolism*; D014133:Tracheal Diseases / Q000378:metabolism
D000682:Amyloid; D007147:Immunoglobulin Light Chains; C035222:amyloid protein AL; D003224:Congo Red