Platelet X-ray microanalysis in patients with chronic renal failure.
The platelet element content was determined by semiquantitative X-ray microanalysis in 6 patients with chronic renal failure. The patients showed a different degree of thrombocytopathy expressed by impaired adhesiveness, epinephrine-induced aggregation and platelet factor 3 availability. The microanalysis indicated significantly increased quantities of phosphorus and copper in patients' platelets. Sodium and zinc showed a decrease in about half of the patients, whereas iron was significantly increased in at least 50% of the patients. Magnesium and potassium did not show any difference from the control. The results of sulfur, chlorine and calcium did not reveal a consistent pattern.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000648:ultrastructure*; D003094:Collagen / Q000494:pharmacology; D003300:Copper / Q000097:blood; D004577:Electron Probe Microanalysis / Q000379:methods; D004602:Elements / Q000097:blood*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D007501:Iron / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000032:analysis; D012310:Ristocetin / Q000494:pharmacology; D012964:Sodium / Q000097:blood; D015032:Zinc / Q000097:blood
D001095:Arachidonic Acids; D004602:Elements; D012310:Ristocetin; D016718:Arachidonic Acid; D010758:Phosphorus; D010977:Platelet Factor 3; D003300:Copper; D003094:Collagen; D012964:Sodium; D007501:Iron; D015032:Zinc; D004837:Epinephrine