[Function of the liver monooxygenase system after exposure to ionol and polychlorinated biphenyls].
After a single administration of polychlorinated diphenyls (sovol) at a dose of 50 mg/kg content of hemoproteins was increased simultaneously with an increase in the rate of N- and O-demethylation in rat liver microsomes. Repeated administrations of a synthetic antioxidant 2,6-ditret-butyl-4-methylphenol (ionol) at a dose of 500 mg/kg stimulated also the liver tissue monooxygenase system; in this case, an increase in content of cytochromes P-450 and b5 was accompanied by a distinct acceleration in oxidation of the first and second types of substrates in microsomes. A combined effect of sovol and ionol maintained the rate of microsomal enzymes induction, which exceeded markedly the values caused by individual effects of the compounds.
D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000815:Aniline Hydroxylase / Q000096:biosynthesis; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D003573:Cytochrome b Group / Q000096:biosynthesis; D015786:Cytochromes b5; D004357:Drug Synergism; D004721:Endoplasmic Reticulum / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003573:Cytochrome b Group; D002084:Butylated Hydroxytoluene; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D000815:Aniline Hydroxylase; C020065:N,N-dimethylaniline demethylase; D010089:Oxidoreductases, N-Demethylating; D000633:Aminopyrine N-Demethylase
Funktsional'noe sostoianie monooksigenaznoĭ sistemy pecheni pri vozdeĭstvii ionola i polikhlorirovannykh difenilov.