title: Lack of antibody induction by Histolyn-CYL, a new skin-testing reagent for histoplasmosis.
abstract: Histolyn-CYL, a yeast phase skin-test reagent, was administered to 85 histoplasmin-sensitive subjects living in the United States and South America. In a multicenter study, sera were obtained at the time the skin tests were read and again 3 weeks later. In no instance did the skin test induce significant complement-fixing antibody changes or antibodies detected by immuno-diffusion.
mesh_terms: D000328:Adult; D000937:Antigen-Antibody Reactions; D000946:Antigens, Fungal; D002140:California; D003105:Colombia; D003168:Complement Fixation Tests; D006659:Histoplasmin; D006660:Histoplasmosis / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D009820:Ohio; D012882:Skin Tests / Q000379:methods
chemical_list: D000946:Antigens, Fungal; C040196:histolyn CYL; D006659:Histoplasmin