title: Stable dicentric chromosomes induced by chemical mutagens in L5178Y mouse lymphoma cells.
abstract: Stable, tandem dicentric chromosomes were discovered in two mutant cell colonies resulting from exposure of L5178Y mouse lymphoma cells to chemical mutagens. These unusual dicentrics were present in all metaphase cells examined from these colonies, even after approximately 65 cell generations in culture. Observation of cells in metaphase and anaphase suggests that the interstitial centromere in these dicentrics is non-functional, and that the terminal centromere is solely responsible for their orderly anaphase segregation.
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives / Q000633:toxicity; D000705:Anaphase / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D006826:Hycanthone / Q000031:analogs & derivatives / Q000633:toxicity; D007621:Karyotyping; D007940:Leukemia L5178 / Q000235:genetics*; D007942:Leukemia, Experimental / Q000235:genetics*; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D009153:Mutagens; D009154:Mutation
chemical_list: D009153:Mutagens; D006826:Hycanthone; C001358:hycanthone methanesulfonate; D000171:Acrolein; C012843:cinnamaldehyde