[Potential adaptation of the gastrointestinal system. Existence of an enteropancreatic trophic axis, the role of hormones and polyamines].
The evidence for an enteropancreatic trophic axis is reviewed. Luminal nutrition is essential for the maintenance of normal intestinal mucosal, as well as exocrine pancreatic structure and function. Exclusion of luminal nutrition leads to mucosal hypoplasia and hypofunction with similar changes in the pancreas. The trophic effect of luminal nutrition may be mediated through the release of regulatory peptides with endocrine or paracrine effects. Enteroglucagon is the strongest candidate for the role of "enterotrophin" while cholecystokinin (CCK) markedly influences pancreatic growth. Thus, CCK not only stimulates exocrine pancreatic secretion but makes acinar cells divide and the pancreas grow. The cellular mechanisms whereby trophic peptides influence normal and adaptive growth are also discussed with emphasis on polyamines (putrescine, spermidine and spermine) and the key enzymes controlling their synthesis (ornithine decarboxylase [ODC]) and degradation (diamine oxidase [DAO]). When polyamine synthesis is blocked with the ODC inhibitor difluoromethyl ornithine (DFMO), the adaptive intestinal hyperplasia of pancreaticobiliary diversion is either inhibited or completely prevented. A proposed sequence of events might be: luminal nutrients, particularly long chain fat, reach the ileum and colon and stimulate increased enteroglucagon release. Enteroglucagon binds to cell receptors and triggers an intracellular cascade involving ODC and the polyamines which, in turn, stimulate RNA polymerase, DNA, RNA and protein synthesis, cell division and adaptive tissue growth.
D000222:Adaptation, Physiological; D000818:Animals; D002766:Cholecystokinin / Q000502:physiology; D004068:Digestive System Physiological Phenomena; D004285:Dogs; D000518:Eflornithine; D005768:Gastrointestinal Hormones / Q000502:physiology*; D004763:Glucagon-Like Peptides / Q000502:physiology; D006801:Humans; D009747:Nutritional Physiological Phenomena; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D010179:Pancreas / Q000254:growth & development / Q000502:physiology*; D011073:Polyamines / Q000502:physiology*; D051381:Rats
D005768:Gastrointestinal Hormones; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines; D004763:Glucagon-Like Peptides; D002766:Cholecystokinin; D009952:Ornithine; D000518:Eflornithine
Potentiel d'adaptation du tractus gastro-intestinal. Existence d'un axe trophique entéro-pancréatique, rôle des hormones et polyamines.