Effects of chlorpromazine and the antidepressant drugs amitriptyline, clomipramine and mianserin on the Ca-depleted rat uterus.
We have investigated the effect of three antidepressants and one phenothiazine on the EDTA-treated rat uterus. It was found that these drugs induce a sustained contraction of tissue in a Ca-free medium (called Ca-free contraction) at concentrations between 5 X 10(-5) and 1 X 10(-4) M. These responses allowed the construction of dose-response curves. However, higher concentrations caused a relaxation of strips contracted by lower doses previously applied. Oxytocin 1 X 10(-2) IU/ml accelerates the appearance of this relaxation. The antidepressants and chlorpromazine at high doses inhibit the oxytocin-induced Ca-free contraction. The drugs-induced Ca-free contraction could be repeated in the same preparation with only a slight reduction in magnitude.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D008803:Mianserin / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*
D000928:Antidepressive Agents; D000639:Amitriptyline; D008803:Mianserin; D010121:Oxytocin; D004492:Edetic Acid; D002997:Clomipramine; D002118:Calcium; D002746:Chlorpromazine