title: Effect of topical acyclovir therapy on experimental herpes simplex keratouveitis.
abstract: Stromal keratitis and associated iritis were produced in rabbit eyes with the intrastromal injection of live herpes simplex virus. Treatment with 3% acyclovir and 2% trifluridine eye ointments was initiated one day after infection and continued for five consecutive days. These therapies significantly suppressed the development of keratouveitis compared with a placebo ointment. The suppressive action of trifluridine ointment on keratouveitis was significantly more pronounced than that of acyclovir ointment.
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000287:Administration, Topical; D000818:Animals; D007500:Iritis / Q000188:drug therapy; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009824:Ointments; D011817:Rabbits; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000008:administration & dosage / Q000627:therapeutic use*; D014605:Uveitis / Q000188:drug therapy*
chemical_list: D009824:Ointments; D014271:Trifluridine; D013936:Thymidine; D000212:Acyclovir