Effect of the Tc-nitrido group on the behaviour of 99mTc-radiopharmaceuticals.
The preparation of the 99mTcN-complexes of gluconate, EHDP, HIDA and PIPIDA by substitution reactions of 99mTcNCl4- is described. Studies of the distribution of these complexes in mice indicate that the presence of the Tc-nitrido group significantly alters the biological properties of the 99mTc-complexes formed using these ligands. Results suggest that the 99mTcN-complexes of these ligands are labile and undergo some ligand exchange in vivo.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D012968:Etidronic Acid; D005942:Gluconates; D007098:Imino Acids; D007700:Kinetics; D051379:Mice; D015609:Organotechnetium Compounds; D013329:Structure-Activity Relationship; D013667:Technetium / Q000378:metabolism; D019780:Technetium Tc 99m Lidofenin; D014018:Tissue Distribution
D005942:Gluconates; D007098:Imino Acids; D015609:Organotechnetium Compounds; C032080:technetium Tc 99m gluconate; C019561:technetium Tc 99m etidronate; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium; C003693:technetium Tc 99m PIPIDA; D012968:Etidronic Acid