title: The degradation of phospholipids, formation of metabolites of arachidonic acid, and demyelination following experimental spinal cord injury.
abstract: Spinal cord injury has been studied using a cat compression model. Very early changes in lipid metabolism were found that compromise the integrity of the plasma membrane and decrease the activities of ATPases. Up to 18% of the ethanolamine plasmalogens are lost, with very marked elevations of the free fatty acids, arachidonic acid, diacylglycerols, prostaglandins, thromboxanes, and leukotrienes. These changes result in edema, inflammation, necrosis of oligodendroglia, demyelination, and paralysis.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002415:Cats; D004075:Diglycerides / Q000378:metabolism; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007796:Laminectomy; D008054:Lipid Peroxides / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism* / Q000502:physiology; D010743:Phospholipids / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D001095:Arachidonic Acids; D004075:Diglycerides; D005230:Fatty Acids, Nonesterified; D008054:Lipid Peroxides; D010743:Phospholipids; D016718:Arachidonic Acid