The effect of short-term immunotherapy with Pollinex on anti-IgE and antigen-induced histamine release from sensitive human basophils.
Anti-IgE and antigen-induced histamine release from basophils isolated from 30 atopic patients sensitive to grass pollen allergens was evaluated. The studies were made before and after short-term immunotherapy with glutaraldehyde-pollen-tyrosine adsorbate (Pollinex). It was shown, that after immunotherapy a significant drop in anti-IgE and specific antigen-induced histamine release from isolated basophils occurs. The investigations confirm that the diminution of the target cell sensitivity and releasability may be one of the effects of specific immunotherapy.
D000447:Aldehydes / Q000008:administration & dosage*; D000485:Allergens / Q000627:therapeutic use*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000494:pharmacology; D052179:Antigens, Plant / Q000627:therapeutic use; D001491:Basophils / Q000032:analysis / Q000187:drug effects / Q000276:immunology*; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D005976:Glutaral / Q000008:administration & dosage* / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007110:Immunity, Active; D007073:Immunoglobulin E / Q000276:immunology / Q000494:pharmacology; D007167:Immunotherapy; D007273:Injections, Intramuscular; D008517:Phytotherapy; D010936:Plant Extracts; D011058:Pollen / Q000008:administration & dosage* / Q000276:immunology / Q000494:pharmacology; D013997:Time Factors; D014443:Tyrosine / Q000008:administration & dosage* / Q000494:pharmacology
D000447:Aldehydes; D000485:Allergens; D000888:Antibodies, Anti-Idiotypic; D052179:Antigens, Plant; D004338:Drug Combinations; D000949:Histocompatibility Antigens Class II; D010936:Plant Extracts; C026408:anti-IgE antibodies; D007073:Immunoglobulin E; D014443:Tyrosine; C014155:Parietaria judaica pollen; D006632:Histamine; D005976:Glutaral