title: [Comparative anorexigenic activity and other pharmacological properties of quipazine and its N-acyl derivatives].
abstract: In experiments on mice and rats quipazine exerts a moderate and short-term anorexigenic activity. N-acyl quipazine derivatives are markedly less toxic, do not exert anorexigenic action and influence weakly the serotoninergic and adrenergic systems.
mesh_terms: D000818:Animals; D001067:Appetite Depressants; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D013747:Tetrabenazine / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
chemical_list: D001067:Appetite Depressants; D011804:Quinolines; D011985:Receptors, Serotonin; D011814:Quipazine; D013747:Tetrabenazine
vernacular_title: Sravnitel'naia anoreksigennaia aktivnost' i drugie farmakologicheskie svoĭstva kvipazina i ego N-atsil'nykh proizvodnykh.