The temperature dependence of halothane-induced contractures of skeletal muscle.
Frog muscles bathed in solutions equilibrated with 0.5%-2.0% halothane develop large contractures when cooled to 2-4 degrees C. These halothane-cooling contractures (HCC) are dose dependent and reproducible; they are potentiated by lidocaine (5 mM), abolished by procaine (5 mM), and partially inhibited by procainamide (5 mM) or sodium salicylate (2 mM). The HCC provides a simple model system for investigating the effects of low halothane concentrations on Ca homeostasis and contractility in skeletal muscle.
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001001:Anura; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D006221:Halothane / Q000494:pharmacology*; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia / Q000188:drug therapy / Q000209:etiology; D009119:Muscle Contraction / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D013696:Temperature
D000779:Anesthetics, Local; D002110:Caffeine; D002118:Calcium; D006221:Halothane