Presence of kappa 2 light chain in normal rabbits and as induced auto anti-allotype antibody in kappa 1 light chain suppressed subjects.
Using an antiserum raised in b(bas)/b(bas)-suppressed rabbits to kappa 2 light chain we have shown that the kappa 2 light chain is an isotype of kappa 1, present in the majority of, if not all, rabbits. It probably exists in at least 2 allelic forms. It is capable of producing a functional antibody molecule (auto anti-b6) and compensates for the absence of kappa 1 light chain in homozygous b6-suppressed rabbits.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D006720:Homozygote; D007106:Immune Sera / Q000276:immunology; D007108:Immune Tolerance; D005779:Immunodiffusion; D007126:Immunoglobulin Allotypes / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis* / Q000276:immunology; D011817:Rabbits
D001323:Autoantibodies; D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007145:Immunoglobulin kappa-Chains