title: Complete tyrosine O-sulfation of gastrin in adult and neonatal cat pancreas.
abstract: We have found gastrin in both the adult and neonatal cat pancreas. In contrast with the main production sites, antrum and duodenum, gastrin in the pancreas occurs in a single molecular form, tyrosine O-sulfated gastrin-17. Since tyrosine sulfation increases the pancreozymic effect of gastrin, the complete sulfation seems functionally expedient.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002415:Cats; D004285:Dogs; D005755:Gastrins / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D005755:Gastrins; C005662:tyrosine O-sulfate; D014443:Tyrosine