Lipid peroxidation as a possible mechanism for the neurotoxic and nephrotoxic effects of a combination of lithium carbonate and haloperidol.
Lithium carbonate as well as haloperidol increased lipid peroxidation in rat cerebral cortex synaptosomes and rat kidney homogenates while sulpiride had no significant effects. A combination of lithium carbonate and haloperidol caused a greater increase in lipid peroxidation than did either lithium carbonate or haloperidol alone. It is concluded that the neurotoxic and nephrotoxic effects of lithium carbonate and haloperidol might be a consequence of increased lipid peroxidation in the cerebral cortex and the kidney, respectively.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D004347:Drug Interactions; D006220:Haloperidol / Q000633:toxicity*; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008094:Lithium / Q000633:toxicity*; D016651:Lithium Carbonate; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013469:Sulpiride / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors
D008054:Lipid Peroxides; D016651:Lithium Carbonate; D013469:Sulpiride; D008094:Lithium; D006220:Haloperidol