[Effect of experimental subarachnoid hemorrhage on calcium incorporation and adrenergic innervation of the cerebral arteries of the cat].
The effect of experimental subarachnoid hemorrhage (SAH) on the adrenergic innervation and on the 45Ca2+ uptake of cat cerebral arteries was analyzed. Intracisternal injections of autologous blood reduced the noradrenaline content of perivascular nerve endings and 3H-noradrenaline uptake. These values returned to normal levels in a period of two weeks after SAH. The activity of dopamine-beta-hydroxylase was also reduced 3 and 7 days after SAH. Superior cervical gangliectomy and intracisternal injection of 6-hydroxydopamine also reduced these three parameters. The uptake of 45Ca2+ by arteries from animals submitted to SAH was greater than if the blood vessels were from untreated cats. Lantanum brought about a less 45Ca2+ displacement in the arterial segments from untreated animals than in those from cats after SAH. These results suggest that SAH induces a transient adrenergic denervation as well as changes in the membrane of smooth muscle cell which increase the quantity of Ca2+ bound to it. All these modifications might be involved in the cause of chronic cerebral vasospasm that appears after SAH.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002415:Cats; D002941:Circle of Willis / Q000294:innervation / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009411:Nerve Endings / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D013562:Sympathectomy
D006892:Hydroxydopamines; D016627:Oxidopamine; D004299:Dopamine beta-Hydroxylase; D002118:Calcium; D009638:Norepinephrine
Efecto de la hemorragia subaracnoidea experimental sobre la incorporación de calcio y la inervación adrenérgica en arterias cerebrales de gato.