Reduction of neophobia in mice following lesions of the caudate-putamen.
Electrolytic lesions of the caudate-putamen result in a significant decrease in neophobic responses in mice towards a novel object introduced into their familiar environment; however, preference for a novel environment was not altered by the lesion. These data provide a parallel between the effects of lesions of the caudate-putamen and the well-known "amygdala-lesion-syndrome." It is suggested that the striatal complex, which receives massive afferent projection systems, plays a crucial role in sensory-motor integration processes which allow the animals to adapt their responses towards biological significant stimuli in order to cope with their environment.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology*; D004777:Environment; D005247:Feeding Behavior / Q000502:physiology; D006120:Grooming / Q000502:physiology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D011699:Putamen / Q000502:physiology*