title: [Metabolic pathways of arachidonic acid: prostaglandins, thromboxane and leukotrienes].
abstract: The powerful and varied biological effects of the metabolites of arachidonic acid suggest that they may play a role in cardiovascular diseases. These substances seem to be involved in a number of pathological situations although there are few satisfactory methods of assessing their role in vivo. At present, it is very difficult to elaborate experiments and/or tests to analyse the production of these autacoids in protocols of clinical investigation reflecting a pharmacological or pathological condition. The development of new methods of study should provide information about the role of these metabolites in the development of cardiovascular diseases.
mesh_terms: D001095:Arachidonic Acids / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000209:etiology / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D019746:Intramolecular Oxidoreductases; D007535:Isomerases / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism*; D013189:SRS-A / Q000378:metabolism*; D013930:Thromboxane-A Synthase / Q000378:metabolism; D013931:Thromboxanes / Q000378:metabolism*
chemical_list: D001095:Arachidonic Acids; D011453:Prostaglandins; D013189:SRS-A; D013931:Thromboxanes; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D007535:Isomerases; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase; D013930:Thromboxane-A Synthase
vernacular_title: Les voies métaboliques de l'acide arachidonique: prostaglandines, thromboxane et leucotriènes.