[Cyclic nucleotides and lipids in the realization of the radioprotective effect of ceruloplasmin].
Ceruloplasmin administered 60 min before irradiation diminished cAMP and cGMP levels, which were increased by irradiation at LD50 and LD100, and normalized cAMP/cGMP ratio in the rat liver during the first 24 h following irradiation with a dose of 6.24 Gy. The content of phospholipids increased and that of cholesterol decreased under the effect of ceruloplasmin leading to normalization of the molar cholesterol/phospholipid ratio in the rat liver on the 7th day of radiation sickness (LD50, 6.24 Gy).
D000818:Animals; D002570:Ceruloplasmin / Q000627:therapeutic use*; D006801:Humans; D008055:Lipids / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology / Q000528:radiation effects; D008297:Male; D009712:Nucleotides, Cyclic / Q000502:physiology*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats
D008055:Lipids; D009712:Nucleotides, Cyclic; D011837:Radiation-Protective Agents; D002570:Ceruloplasmin
Tsiklicheskie nukleotidy i lipidy v realizatsii radiozashchitnogo deĭstviia tseruloplazmina.