[Proliferative activity of the uterine epithelium and mesenchymal elements in CBA-strain mice administered 1,2-dimethylhydrazine and estradiol dipropionate].
Difference have been demonstrated in proliferative responses of epithelial and mesenchymal cells in the uterus of CBA mice under administration of 20 weekly subcutaneous injections of 1,2-dimethylhydrazine (DMH) and estradiol dipropionate (EP) separately and in combination (DMH+EP). The proliferative pool (Pc) of uterine glands epithelium increases under the effect of EP and decreases under the effect of both DMH and DMH+EP. The proliferative pool of mesenchymal cells increases under the effect of DMH, EP, and DMH+EP 5 to 10 weeks after the beginning of their administration, then it decreases. But percentage of DNA synthesizing cells in the regions of hyperplasia and the tumour formation enhances significantly by the 15th to 20th weeks after the beginning of DMH+EP administration.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004127:Dimethylhydrazines / Q000633:toxicity*; D004357:Drug Synergism; D004714:Endometrial Hyperplasia / Q000139:chemically induced / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives* / Q000633:toxicity; D004971:Estrus / Q000187:drug effects; D005260:Female; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000473:pathology; D014599:Uterus / Q000166:cytology / Q000187:drug effects*
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate
Proliferativnaia aktivnost' épiteliia i mezenkhimnykh élementov matki mysheĭ linii CBA pri vvedenii 1,2-dimetilgidrazina i éstradioldipropionata.