title: Mitochondrial myoneuropathy with respiratory failure and myoclonic epilepsy. A case report with biochemical studies.
abstract: A 55-year-old man is presented who developed severe multifocal myoclonus and tonic clonic seizures in his early thirties, and progressive limb weakness in his mid forties, when a ragged red fibre myopathy was diagnosed. He went on to develop a distal motor neuropathy and respiratory failure. Respiratory function tests indicated respiratory failure secondary to respiratory muscle weakness and a central hypoventilation syndrome. CT scan revealed brain stem atrophy and brain stem evoked responses were abnormal. A sural nerve biopsy showed severe axonal degeneration. Cytochrome difference spectra and polarographic studies on isolated intact muscle mitochondria were normal. This study reports the association of respiratory failure and sleep apnoea with Fukuhara's syndrome and presents biochemical data suggesting that the mitochondrial respiratory chain may be intact in some patients with this syndrome.
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D001706:Biopsy; D004831:Epilepsies, Myoclonic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000032:analysis / Q000473:pathology*; D009207:Myoclonus / Q000378:metabolism* / Q000473:pathology; D010101:Oxygen Consumption; D012119:Respiration; D012131:Respiratory Insufficiency / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology
chemical_list: D000244:Adenosine Diphosphate