title: Mucosal destruction and regeneration of the colon by local hyperthermia. An experimental preliminary study.
abstract: An experimental model has been developed to produce colonic mucosal destruction followed by regeneration. The canine model consists of a defunctioned portion of the large intestine which has been subjected to water at a temperature of 125 degrees F for 7 hours. Colonic specimens were harvested at different periods of up to six weeks and studied macro- and microscopically. It has been shown that it is possible to achieve significant mucosal destruction and regeneration. Possible adaptation to clinical states is presented and discussed.
mesh_terms: D000042:Absorption; D000818:Animals; D003106:Colon / Q000254:growth & development* / Q000378:metabolism; D003108:Colonic Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D006358:Hot Temperature; D009092:Mucous Membrane / Q000378:metabolism; D009336:Necrosis; D014994:Xylose / Q000378:metabolism
chemical_list: D014994:Xylose