title: Antibody-toxin hybrids: a clinical review of their use.
abstract: Immunotoxins are protein molecules composed of monoclonal antibodies linked covalently to either peptide toxins or polypeptides related to toxins. These molecules can be used in the therapy of a number of malignant diseases including lymphoma, leukemia, and solid tumors. They can be used to prevent graft-versus-host disease or rejection in transplanted organs, such as bone marrow and pancreas. The design and development of these molecules, as well as a clinical development plan, will be discussed.
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D005260:Female; D006801:Humans; D016381:Islets of Langerhans Transplantation; D009369:Neoplasms / Q000628:therapy; D010051:Ovarian Neoplasms / Q000628:therapy; D014118:Toxins, Biological / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D014118:Toxins, Biological