title: A study of cryosurgery and the CO2 laser in treatment of carcinoma in situ (CIN III) of the uterine cervix.
abstract: The results of laser and cryosurgical treatment in 106 patients with histologically proven carcinoma in situ of the uterine cervix (CIN III) are presented. Seventy-one patients were treated with the laser and in 63 of these further follow-up with colposcopy and cytology failed to show any abnormality. This represents an initial success rate of 89%. In 8 patients (11%) initial treatment was considered to have failed because of persistent dyskaryotic smears and histological evidence of cervical intraepithelial neoplasia (CIN II-III). Six of these patients were treated successfully with a further laser application and two patients had conization. The overall success rate for the laser was 97%. Thirty-five patients were treated with cryosurgery and subsequent follow-up was negative in 29 of these patients (83%). The 6 treatment failures (17%) were subsequently successfully treated with local destructive therapy (4 with cryosurgery, 1 with laser, and 1 with needle diathermy). The overall success rate for cryofreezing was 94.2%. In cases of CIN III the laser is more likely to achieve eradication of the lesion with a single application than cryofreezing.
mesh_terms: D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide; D002278:Carcinoma in Situ / Q000601:surgery*; D002986:Clinical Trials as Topic; D003452:Cryosurgery; D005260:Female; D006801:Humans; D007223:Infant; D053685:Laser Therapy; D008875:Middle Aged; D011183:Postoperative Complications; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation; D002583:Uterine Cervical Neoplasms / Q000601:surgery*
chemical_list: D002245:Carbon Dioxide