The effect of fluoride on chromosome aberration and sister-chromatid exchange frequencies in cultured human lymphocytes.
Sodium fluoride, at concentrations of up to 60 times the level normally used in drinking water for the prevention of dental decay, was compared with 2 other inorganic salts for its ability to induce chromosome aberrations and sister-chromatid exchanges (SCE) in cultured human lymphocytes. No significant increases in the frequencies of aberrations of SCEs were found.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D005459:Fluorides; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology*
D008937:Mitomycins; D017680:Potassium Compounds; D012965:Sodium Chloride; D016685:Mitomycin; D012969:Sodium Fluoride; C033320:potassium fluoride; D005459:Fluorides; D011188:Potassium