[The suitability of propylene glycol (1,2-propanediol) as an active antimicrobial adjuvant in ointments].
Propylene glycol was tested for its antimicrobial activity as well as its possible irritant effect in ointments. With regard to the antimicrobial effect, vehicles containing more than 5% propylene glycol proved to be superior to those containing glycerol. 269 volunteers with or without eczema who had been treated with 10% propylene glycol under occlusion and by means of the Duhring chamber method, showed very few irritations; there was almost none observed in patients tested with an ointment containing glycerol instead. We did not find any allergic sensitization against propylene glycol.
D000277:Adjuvants, Pharmaceutic; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001419:Bacteria / Q000187:drug effects*; D004485:Eczema / Q000188:drug therapy*; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology; D006801:Humans; D009824:Ointments; D010407:Penicillium / Q000187:drug effects; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000277:Adjuvants, Pharmaceutic; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009824:Ointments; D011409:Propylene Glycols; D019946:Propylene Glycol; D005990:Glycerol
Uber die Eignung von Propylenglykol (1,2-Propandiol) als antimikrobiell wirksamer Hilfsstoff für Cremesysteme.