title: Prophage induction and filamentation in Bacillus thuringiensis caused by the genotoxic mycotoxin aflatoxin B1.
abstract: Cultures of the lysogenic strain of Bacillus thuringiensis var. tolworthi were made in the presence of various drugs. The determination of bacterial size and plaque forming units (by using an indicator strain of B. thuringiensis var. galleriae) as well as colony forming units were then performed. Treatment of lysogenic cells by aflatoxin B1: provokes the formation of elongated cells (filamentation); induces a pathway that leads to the induction of prophage. Results of the present study indicated that filament formation and bacteriophage induction are two commonplace effects that occur in virtually every member of this cellular population exposed to low doses of certain drugs such as aflatoxin B1 (10 micrograms/ml); all of which have in common the ability to produce damaging changes in DNA. The following findings support the hypothesis that error-prone repair mechanisms seem to be present in B. thuringiensis as in Escherichia coli.
mesh_terms: D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D001413:Bacillus thuringiensis / Q000166:cytology / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000348:Aflatoxins; D008937:Mitomycins; D016685:Mitomycin; D016604:Aflatoxin B1