title: A dramatic loss of cumulus cell gap junctions is correlated with germinal vesicle breakdown in rat oocytes.
abstract: Interactions between the cumulus-oophorus and the oocyte have been implicated in the regulation of meiotic maturation. Quantitative analysis of freeze-fractured rat cumulus-oocyte complexes reveals that the net area of cumulus cell gap junction membrane decreases about 15-fold, 2-3 hr following an ovulatory stimulus. This dramatic loss of gap junctions is temporally correlated with germinal vesicle breakdown and cumulus expansion, and is discussed with respect to meiotic maturation and ovulation of the mammalian oocyte.
mesh_terms: D000818:Animals; D002450:Cell Communication; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D007365:Intercellular Junctions / Q000502:physiology* / Q000648:ultrastructure; D008540:Meiosis; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology / Q000648:ultrastructure*; D010060:Ovulation; D051381:Rats
chemical_list: D006063:Chorionic Gonadotropin