Suppression by the cyclohexanetrione Ro 31-0521 of retinoic acid-induced teratogenicity.
The cyclohexanetrione Ro 31-0521, which stimulates prostaglandin synthesis, inhibited retinoic acid-induced cartilage degradation in vitro and suppressed the congenital forelimb malformations in rats treated with retinoic acid on day 13 of gestation in a dose-dependent manner.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities / Q000196:embryology; D002356:Cartilage / Q000196:embryology* / Q000378:metabolism; D046508:Culture Techniques; D003510:Cyclohexanes / Q000494:pharmacology*; D003512:Cyclohexanones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005552:Forelimb / Q000002:abnormalities*; D011247:Pregnancy; D011509:Proteoglycans / Q000378:metabolism; D051381:Rats; D014212:Tretinoin / Q000037:antagonists & inhibitors* / Q000633:toxicity
D003510:Cyclohexanes; D003512:Cyclohexanones; D011509:Proteoglycans; C047848:Ro 31-0521; D014212:Tretinoin