title: [Prealbumin and retinol-binding protein].
abstract: Thyroxin binding prealbumin (TBPA) and retinol binding protein (RBP) are associated in a complex responsible for the transport of vitamin A and of about 10% of the thyroid hormones T3 and T4. Both are synthetized in the liver. RBP can be characterized by two essential points: its hepatic secretion depending on the nutritional vitamin A status explains the close relation noted between these two parameters; its catabolism located in the renal tubular cells indicates the important role played by kidney in its metabolism. The concentrations, in serum of normal healthy adults, of TBPA and RBP are respectively 323 mg/l and 63 mg/l for men, 283 mg/l and 52 mg/l for women. In these cases the variations of the two proteins are significantly correlated. In patients with liver diseases and with protein deficiency, there is a lack of synthesis of TBPA and RBP (deficiency in substrate and/or decrease in hepatic synthesis). In vitamin A deficiency and in renal failure, RBP alone is disturbed.
mesh_terms: D000375:Aging; D000728:Androgens / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport; D055598:Chemical Phenomena; D002621:Chemistry; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology; D006505:Hepatitis / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D008970:Molecular Weight; D011379:Prognosis; D011488:Protein Deficiency / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D012177:Retinol-Binding Proteins / Q000502:physiology*; D013959:Thyroid Diseases / Q000378:metabolism; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000502:physiology*; D014801:Vitamin A / Q000097:blood; D014802:Vitamin A Deficiency / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology
chemical_list: D000728:Androgens; D004967:Estrogens; D005938:Glucocorticoids; D046911:Macromolecular Substances; D012177:Retinol-Binding Proteins; D013975:Thyroxine-Binding Proteins; D014801:Vitamin A; D015032:Zinc; D013974:Thyroxine
vernacular_title: Préalbumine et retinol binding protein.