Increase of predominantly k-type light chains in the CSF of a case of subacute sclerosing panencephalitis treated with interferon.
The results of a study of the CSF protein pattern in a case of SSPE treated with interferon are reported. An increase in the IgG, IgG index and CNS IgG synthesis values was found during and after the period of treatment. The electrophoretic and IEF patterns show a predominant increase in the L-chain bands, principally k-type, which are anti-measles antibodies. It is suggested that interferon could stimulate some cell clones to synthesize a particular type of L-chains.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000134:cerebrospinal fluid*; D007145:Immunoglobulin kappa-Chains / Q000134:cerebrospinal fluid*; D007370:Interferon Type I / Q000627:therapeutic use*; D007525:Isoelectric Focusing; D008297:Male; D012967:Sodium Dodecyl Sulfate; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid / Q000188:drug therapy*
D000914:Antibodies, Viral; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007370:Interferon Type I; D012967:Sodium Dodecyl Sulfate