title: Benzylpenicillin in mice. Effect of meningococci on plasma concentrations.
abstract: Plasma concentration studies were performed in mice given high intravenous (i.v.) bolus injections or subcutaneous (s.c.) depot doses of benzylpenicillin. There was a marked difference in plasma concentration within and between individuals both after benzylpenicillin (BP) given i.v. and after benzylpenicillin procaine (BPP) given s.c. BP given i.v. resulted in a plasma half-life of 15.2 minutes, while BPP given s.c. resulted in a plasma half-life of 2.7 hours. Infection with an endotoxin-liberating meningococcal strain in BP-treated animals increased the plasma levels of BP compared with uninfected controls.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D008585:Meningitis, Meningococcal / Q000097:blood* / Q000188:drug therapy; D051379:Mice; D009345:Neisseria meningitidis; D010400:Penicillin G / Q000097:blood*; D010402:Penicillin G Procaine / Q000097:blood
chemical_list: D010402:Penicillin G Procaine; D010400:Penicillin G