title: [Monoclonal gammopathies: classification of laboratory tests].
abstract: Monoclonal gammopathies have been examined and classified. In the field of chemico-clinical and immunological investigations, the various methods of analysing dysproteinaemia, of which the monoclonal component is a typical expression (electrophoresis, radial immunodiffusion, immunoelectrophoresis, immunofixation), and the main haematological and immunohaematological changes (lymphocyte biological markers) involved are reviewed. After describing the main histological and histo-cytochemical investigations, particularly amyloidosis, electronic microscope aspects and the most important chromosome abnormalities revealed by karyotype study are reported for their diagnostic interest.
mesh_terms: D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology; D001778:Blood Coagulation Disorders / Q000175:diagnosis; D001797:Blood Protein Electrophoresis; D001809:Blood Viscosity; D002118:Calcium / Q000097:blood; D019411:Clinical Laboratory Techniques / Q000145:classification*; D003404:Creatinine / Q000097:blood; D003450:Cryoglobulins / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000175:diagnosis; D010265:Paraproteinemias / Q000175:diagnosis*; D010266:Paraproteins / Q000032:analysis; D010974:Platelet Aggregation; D012397:Rosette Formation; D014508:Urea / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D003450:Cryoglobulins; D006680:HLA Antigens; D010266:Paraproteins; D001613:beta 2-Microglobulin; D014508:Urea; D003404:Creatinine; D002118:Calcium
vernacular_title: Le gammopatie monoclonali: inquadramento delle indagini di laboratorio.