Lethal effect of male rat submandibular gland homogenate for rat neonates.
Suckling rats injected subcutaneously with male submandibular gland homogenate (SMGH), but not liver homogenate (LH), died within 24 h. Weanling and adult rats injected with proportionately greater doses of male SMGH did not die. Suckling rats injected with male SMGH exhibited a 1200% increase in serum trypsin-like activity while the corresponding increase for an adult receiving a proportionately similar dose was 46%. We suggest that pups injected subcutaneously with SMGH absorbed trypsin-like enzymes into their bloodstream, were unable to inactivate the enzymes, and suffered a hypotensive crisis leading to death.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D005260:Female; D008099:Liver / Q000502:physiology; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000201:enzymology / Q000502:physiology*; D014020:Tissue Extracts / Q000009:adverse effects*; D014357:Trypsin / Q000009:adverse effects / Q000378:metabolism
D014020:Tissue Extracts; D014357:Trypsin