[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].
Single doses of phenytoin (500 and 1.000 mg), carbamazepine 400 and 1.00 mg) and sodium valproate (600 mg) were given orally to 5 healthy young volunteers and serum concentrations determined between 1-8h after administration. The design was double-blind and placebo-controlled. Serum concentrations considered "therapeutic" were obtained after sodium valproate and the 100 mg dose of carbamazepine. The results suggest the loading-doses of phenytoin (1500-2000 mg) and carbamazepine (800 mg) are useful in the subacute control of frequent epileptic seizures on an out-patient basis, and that carbamazepine may be used for lasting control of seizures of status epilepticus treated initially with diazepam or other rapidly-acting preparation.
D000042:Absorption; D000284:Administration, Oral; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004827:Epilepsy / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D014635:Valproic Acid / Q000008:administration & dosage / Q000097:blood*
D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin
Concentrações séricas eficazes após doses únicas de drogas anti-epiléticas: conceito de dose carga.