The generation of dense granules within cultured human retinal pigment epithelial cells at senescence.
Human retinal pigment epithelial cells routinely lose all forms of pigmentary inclusion when cultured. We report the repigmentation of a senescent population of cells. The pigmented inclusions were found to be neither melanin or lipofuscin but some form of dense membranous lamellae.
D002470:Cell Survival; D002478:Cells, Cultured; D002675:Child, Preschool; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D006801:Humans; D007849:Laurence-Moon Syndrome / Q000473:pathology; D008854:Microscopy, Electron; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000648:ultrastructure*