title: [Biological effects of new PAS derivatives on Mycobacterium tuberculosis].
abstract: A new series of p-aminosalicylic acid derivatives were tested in vitro against Myc.tbc. H37Rv strain and clinically isolated pathogenic mycobacteria. 4 - [alpha - (benzylamino - thiocarbonylthio) - acetamido] - salicylic acid was most active, 4 - [alpha - methyl - alpha - (furfurylamino - thiocarbonylthio) - acetamido] - salicylic acid was more active than PAS. 4 - [alpha - (ethylamino - thiocarbonylthio) - acetamido] - salicylic acid, and 4 - [alpha - methyl - alpha - (ethylamino - thiocarbonylthio) - acetamido] - salicylic acid derivatives were nearly as active as PAS. The causes of increase in tuberculostatic activity can be assumed to be the isothiocyanate groups, which are the products of hydrolysis of the compounds investigated.
mesh_terms: D010131:Aminosalicylic Acid / Q000494:pharmacology; D000636:Aminosalicylic Acids; D066298:In Vitro Techniques; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000636:Aminosalicylic Acids; D010131:Aminosalicylic Acid
vernacular_title: Yeni bazi PAS türevlerinin Mycobacterium tuberculosise karşi biyolojik etkilerinin incelenmesi.