title: Two types of changes in skin conductance activity after intraventricular administration of 6-hydroxydopamine in rats.
abstract: Sixteen male Wistar strain rats were trained to have their skin conductance activity recorded through the soles of their hind limbs, and the effects of the intraventricular administration of 6-OHDA (200 micrograms) on this activity were studied. The intact rats showed skin conductance response and its habituation to repeated auditory stimuli (500 Hz, 90 dB, 1 sec). The 6-OHDA-treated rats exhibited either obliteration of the response or impairment of the habituation. The nonresponding state tended to be accompanied by a low rate of spontaneous skin conductance fluctuation, but the nonhabituating state was not accompanied by changes of the rate. The vehicle-treated rats showed no change in these activities. These electrodermal characteristics were discussed along with the CA hypothesis of schizophrenia.
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D005712:Galvanic Skin Response / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001679:Biogenic Amines; D006892:Hydroxydopamines; D016627:Oxidopamine