Inhibition by dietary organoselenium, p-methoxybenzene-selenol, of hepatocarcinogenesis induced by azoxymethane in rats.
The effect of dietary p-methoxybenzeneselenol, a new organoselenium compound, on azoxymethane (AOM)-induced hepatocarcinogenesis was examined in female F344 rats. Semipurified diets containing 0 and 5 ppm p-methoxybenzeneselenol were fed to the rats, starting at 5 weeks of age until one week after the carcinogen treatment. At 7 weeks of age, all animals except the vehicle-treated controls were given weekly sc injections of AOM (15 mg/kg body weight, 3 times). At 34 weeks after the last AOM treatment, the liver neoplasm incidence and liver tumor multiplicity as well as the incidence of altered liver cell foci were significantly lower in AOM-treated rats fed the diet containing 50 ppm p-methoxybenzeneselenol (tumor incidence 19%, tumor multiplicity 0.45/rat, foci incidence 3.47/cm2) than in AOM-treated animals fed the diet without p-methoxybenzeneselenol (tumor incidence 66%, tumor multiplicity 2.24/rat, foci incidence 12.08/cm2). These results indicate that dietary p-methoxybenzeneselenol at a dose of 50 ppm inhibits AOM-induced hepatic tumorigenesis.
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001391:Azo Compounds; D001397:Azoxymethane; D001835:Body Weight; D004032:Diet; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D016566:Organoselenium Compounds; D051381:Rats; D011916:Rats, Inbred F344; D012643:Selenium / Q000494:pharmacology*
D000840:Anisoles; D001391:Azo Compounds; D016566:Organoselenium Compounds; C045562:4-methoxybenzeneselenol; D012643:Selenium; D001397:Azoxymethane