The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma.
The plasma activity level of the recently discovered fast-acting inhibitor of tissue-type plasminogen activator (t-PA) was found to be temporarily increased after surgery, myocardial infarction and severe trauma. Detailed analysis of the postoperative period revealed simultaneously increased t-PA antigen and inhibition and decreased t-PA activity only on the first postoperative day. These changes were more rapid than those in fibrinogen and C-reactive protein. It is concluded that t-PA inhibition shows the most rapidly changing pattern observed so far in response to trauma. The postoperative fibrinolytic shutdown in blood fibrinolytic activity can be ascribed to a primary increase in t-PA inhibitor levels.
D000941:Antigens / Q000032:analysis; D005342:Fibrinolysis; D050723:Fractures, Bone / Q000097:blood; D006801:Humans; D011184:Postoperative Period; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors* / Q000097:blood / Q000276:immunology
D000941:Antigens; D010959:Tissue Plasminogen Activator