High concentrations of enolase, alpha- and gamma-subunits, in the aqueous humor in cases of retinoblastoma.
Because retinoblastomas contain a large amount of the gamma-subunit of enolase or neuronspecific enolase, we studied the aqueous humor levels of the gamma-subunit and alpha-subunit in 12 cases of retinoblastoma. Enzyme immunoassay demonstrated that both the gamma-subunit and the alpha-subunit were greatly increased in all 12 (minimum levels, 87.8 ng/ml and 354 ng/ml, respectively). Thus, aqueous enolase levels, especially that of the gamma-subunit, are useful in the diagnosis of retinoblastoma and may be useful as monitoring markers in retinoblastoma involving the central nervous system.
D000368:Aged; D001082:Aqueous Humor / Q000201:enzymology*; D002675:Child, Preschool; D005134:Eye Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D009994:Osmolar Concentration; D010751:Phosphopyruvate Hydratase / Q000145:classification / Q000378:metabolism*; D012175:Retinoblastoma / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology
D007527:Isoenzymes; D010751:Phosphopyruvate Hydratase