[Studies on the combination action of sisomicin, gentamicin and cefmenoxime, ceftizoxime, cefoperazone, cefotetan against Serratia marcescens and Pseudomonas aeruginosa].
The combined actions of sisomicin (SISO), gentamicin (GM) and cefmenoxime (CMX), ceftizoxime (CZX), cefoperazone (CPZ), cefotetan (CTT) against S. marcescens IFO-3735 and P. aeruginosa IFO-12689 were investigated. The results were summarized as follows. The synergistic effect of the combinations of SISO-CMX, SISO-CZX, SISO-CPZ, SISO-CTT, GM-CMX, GM-CZX, GM-CPZ and GM-CTT using the checker board dilution method on S. marcescens IFO-3735 and P. aeruginosa IFO-12689 were found. Especially the minimum FIC index value of combination of SISO-CTT and GM-CTT were rather low as 0.14 and 0.13, respectively and these synergistic effect was remarkably strong on S. marcescens IFO-3735. With the killing kinetic method, all combinations tested showed the synergistic effect in both bacteria.
D015281:Cefmenoxime; D002438:Cefoperazone / Q000494:pharmacology*; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D015313:Cefotetan; D015296:Ceftizoxime; D002513:Cephamycins / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D005839:Gentamicins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012706:Serratia marcescens / Q000187:drug effects*; D012853:Sisomicin / Q000494:pharmacology*
D002513:Cephamycins; D004338:Drug Combinations; D005839:Gentamicins; D015313:Cefotetan; D002438:Cefoperazone; D015296:Ceftizoxime; D015281:Cefmenoxime; D002439:Cefotaxime; D012853:Sisomicin