Progressive cardiac involvement by Fabry's disease despite successful renal allotransplantation.
Enzyme replacement by renal allotransplantation has been suggested as a specific mode of therapy for Fabry's disease. We report a case of Fabry's disease who developed symptoms and signs of heart failure despite successful renal transplantation 14 years ago. Echo- and angiocardiographic features resembled findings in patients with hypertrophic non-obstructive cardiomyopathy. Endomyocardial biopsy specimens demonstrated cardiac manifestation of Fabry's disease.
D001706:Biopsy; D004699:Endocardium / Q000473:pathology; D000795:Fabry Disease / Q000473:pathology*; D006338:Heart Neoplasms / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011183:Postoperative Complications / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology