Detecting mitomycin C in human plasma during intravesical therapy.
Mitomycin C (MMC) concentrations in plasma and urine were measured in five patients with intact bladder during intravesical instillation therapy. No MMC was detected in plasma by a selective high performance liquid chromatographic (HPLC) method. The detection limit of the method is 1 ng/ml. Our results are in accordance with clinical experiences of the lack of systemic toxicity during MMC instillation therapy. There was a remarkable loss of MMC in the voided urine. The probable explanation could be that a considerable amount of MMC is absorbed into the bladder wall.
D000287:Administration, Topical; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use / Q000652:urine; D001743:Urinary Bladder; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000652:urine
D008937:Mitomycins; D016685:Mitomycin