title: tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster.
abstract: Developmental analysis of a newly isolated maternal effect grandchildless mutant, tudor (tud), in Drosophila melanogaster indicates that tud+ activity is required during oogenesis for the determination and/or formation of primordial germ cells (pole cells) and for normal embryonic abdominal segmentation. Regardless of their genotype, progeny of females homozygous for strong alleles (tud1 and tud3) never form pole cells, apparently lack polar granules in the germ plasm, and approximately 40% of them die during late embryogenesis exhibiting severe abdominal segmentation pattern defects. Females carrying weak allele, tud4, produce progeny with some functional pole cells and form polar granules approximately one-third the size of those observed in wild-type oocytes and embryos. No segmentation abnormalities are observed in the inviable embryos derived from tud4/tud4 females.
mesh_terms: D000483:Alleles; D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D005260:Female; D005796:Genes; D005816:Genetic Complementation Test; D005854:Germ Cells; D008297:Male; D009154:Mutation; D009865:Oocytes / Q000648:ultrastructure; D009866:Oogenesis