Iron exclusion by proliferative foci and neoplastic lesions induced by 7,12-dimethylbenz(a)anthracene in the rat adrenal cortex.
Proliferative and neoplastic adrenal cortical lesions were produced in female Sprague-Dawley rats by 7,12-dimethylbenz(a)anthracene. These lesions were studied for their ability to store histochemically demonstrable cellular iron compared with normal adrenocortical cells following iron loading by subcutaneous injection of iron-dextran. Stainable iron was excluded, under conditions in which normal cortical cells were heavily loaded with iron, in three histological types of adrenal cortical lesions; eosinophilic and basophilic proliferative foci; adenomas and lesions transitional between foci and tumours. The property of iron exclusion may be useful in studying neoplastic development in the adrenal gland.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000236:Adenoma / Q000139:chemically induced; D000302:Adrenal Cortex / Q000378:metabolism / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D007501:Iron / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains
D015127:9,10-Dimethyl-1,2-benzanthracene; D007501:Iron