title: The effects of external CO2 application on human skin microcirculation investigated by laser Doppler flowmetry.
abstract: The effects of an aqueous solution of CO2 applied to a small skin site were investigated by means of a laser Doppler flowmeter. The circulatory response to CO2 was an increased blood flow, reaching a maximum level within approximately 2-3 minutes. In addition there was a marked stimulation of rhythmical vasomotion, especially an increase in amplitudes. The effects, strongly dependent on dose and temperature, ceased rapidly when the CO2 sample was withdrawn.
mesh_terms: D002245:Carbon Dioxide / Q000494:pharmacology*; D004301:Doppler Effect; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D007834:Lasers; D008722:Methods; D008833:Microcirculation / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013696:Temperature; D014463:Ultrasonography
chemical_list: D002245:Carbon Dioxide