title: [Circadian behavior of oxygen consumption of rats with and without peripheral chemical sympathectomy with 6-OH-dopamine].
abstract: The circadian rhythm of the night-active rats is reflected unequivocally in measurements of oxygen consumption under natural light conditions in investigations conducted from mid-March to mid-May. A phase of rest lasting from about 10 a.m. to 6 p.m. is followed by a phase of increasing activity, showing a first peak at about 10 p.m. and its climax around 6 a.m. and being followed by a phase of transition in which the values for oxygen consumption of the resting phase are reached again. The peripheral chemical sympathectomy by 100 mg 6-OH-dopamine/kg b.w. i.p. causes heavy behavioral disorders in the rats. Four to 6 h following this intervention extremely low values for the oxygen consumption are found, which rise again in the following 16 h to values corresponding to the resting phase of the animals of the control group. The circadian rhythm of the rats, as represented by the oxygen consumption, is extinguished at the time from 24-48 h following the application of 6-OH-dopamine. The oxygen consumption values fluctuate, without phases being observable, around a daily average value corresponding to that of the control values. Thus, the sympathetic nervous system is of essential importance for the course of the circadian rhythm in the rat. On the other hand, the sympathetic nervous system is replaced by an unknown mechanism to a degree that ensures the viability of the rats.
mesh_terms: D000818:Animals; D001831:Body Temperature; D002940:Circadian Rhythm; D005260:Female; D006892:Hydroxydopamines; D016627:Oxidopamine; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D013563:Sympathectomy, Chemical; D013997:Time Factors
chemical_list: D006892:Hydroxydopamines; D016627:Oxidopamine
vernacular_title: Das zirkadiane Verhalten des Sauerstoffverbrauchs von Ratten ohne und nach peripherer chemischer Sympathektomie durch 6-OH-Dopamin.