Neutropenia and thrombocytopenia: antibodies directed against circulating neutrophils and bone marrow myeloid progenitor cells (CFU-C).
The pathophysiology of a neutropenic disorder was evaluated in a 60-year-old man using myeloid progenitor cell (CFU-C), colony stimulating activity (CSA), and antineutrophil antibody assays. An immunoglobulin, present in the patient's serum at presentation, was directed against peripheral blood neutrophils, and autologous and allogeneic bone marrow CFU-C. A course of prednisone resulted in resolution of the neutropenia and a disappearance of the cytotoxic antibody. This study suggests that the patient's neutropenic disorder resulted from antibody-mediated destruction of circulating neutrophils and a suboptimal bone marrow granulopoietic response.
D000380:Agranulocytosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D011241:Prednisone