[Relation between therapeutic efficacy of antianginal preparations in patients with ischemic heart disease and their effect on the rheologic properties of blood].
The effects of a variety of currently-used anti-anginal drugs on major hemorheologic parameters (blood viscosity in the 0.692-2348 s-1 variation rates range, plasma viscosity, erythrocyte and platelet function) and also the hemostatic system were examined in 100 chronic coronary patients during specific treatment courses. The nitrates, beta-blockers (alone or in combinations), cordaron and molsidomin were shown to produce positive effects on blood rheology. A relationship was demonstrated between physical stress tolerance and blood viscosity pattern in propranolol-treated coronary patients. It is suggested that positive hemorheologic effects of anti-anginal drugs may be an important constituent of their therapeutic action and, as such, provide an additional marker of their efficiency in coronary heart disease.
D000328:Adult; D000638:Amiodarone / Q000627:therapeutic use*; D001572:Benzofurans / Q000627:therapeutic use*; D001777:Blood Coagulation; D001809:Blood Viscosity; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D004903:Erythrocyte Aggregation; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008981:Molsidomine; D005996:Nitroglycerin / Q000627:therapeutic use*; D010069:Oxadiazoles / Q000627:therapeutic use*; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011433:Propranolol / Q000627:therapeutic use*; D013558:Sydnones / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D001572:Benzofurans; D010069:Oxadiazoles; D013558:Sydnones; D014665:Vasodilator Agents; D011433:Propranolol; D008981:Molsidomine; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D000638:Amiodarone
Terapevticheskaia éffektivnost' antianginal'nykh preparatov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa v sviazi s ikh vliianiem na reologicheskie svoĭstva krovi.