Construction and evaluation of a coronary catheter for chronic implantation in dogs.
Construction of a Silastic catheter and the procedure for chronic implantation in a coronary artery in dogs is described. In addition, studies designed to evaluate whether chronic coronary artery catheterization altered coronary vascular reactivity and myocardial function are presented. The results of these studies indicate that chronic implantation of the catheter in a coronary artery of conscious dogs does not significantly interfere with the normal reactivity of the coronary vascular bed, does not compromise regional or global left ventricular function, and does not induce collateral vessel development. This technique will be useful in studies involving the neural and metabolic regulation of the coronary circulation in animals subjected to exercise and/or exercise training.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation*; D003097:Collateral Circulation; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000601:surgery; D004285:Dogs; D005069:Evaluation Studies as Topic; D006321:Heart / Q000502:physiology; D005082:Physical Exertion; D012039:Regional Blood Flow / Q000187:drug effects
D000241:Adenosine