[Synergism of the anti-anginal action of beta-blockers and calcium antagonists in patients with ischemic heart disease].
A variety of anti-anginal drugs and their combinations were selected in a group of patients with stable angina of effort, with the effects assessed by bicycle ergometry. Effective doses of propranolol, corinfar, finoptin provided for at least 3 minutes' increment in the duration of the effort. Combinations of these drugs in doses reduced by half produced a more pronounced increment in the duration of the effort, an observation suggestive of synergistic anti-anginal effects of calcium antagonists and beta-blockers.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy; D001794:Blood Pressure; D003327:Coronary Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage*; D014700:Verapamil / Q000008:administration & dosage*
D011433:Propranolol; D014700:Verapamil; D005996:Nitroglycerin; D009543:Nifedipine
Izuchenie sinergizma antianginal'nogo deĭstviia beta-blokatorov i antagonistov kal'tsiia u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.