Familial juvenile parkinsonism with multiple systems degenerations. A clinicopathological study.
An unusual case of familial multisystemic degeneration is reported. Two siblings had juvenile parkinsonism, areflexia, and retinal degeneration of slow progression. The main neuropathological findings in case 1 were pallidoluysian, nigral, dentate, and dorsal columns degeneration. The authors draw a comparison between this case and juvenile parkinsonism, dentato-rubro-pallido-luysian atrophy, and spino-cerebello-nigral degeneration.
D000328:Adult; D000367:Age Factors; D001284:Atrophy; D001921:Brain / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D010300:Parkinson Disease / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D012160:Retina / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology