Increase in enzyme activities of prostaglandin biosynthesis and catabolism by acute ureteral ligation in rat kidney.
Acute ureteral obstruction increased cyclooxygenase, thromboxane and prostacyclin synthases and NAD+-linked 15-hydroxyprostaglandin dehydrogenase activities in rat kidney. Significant increase in prostaglandin biosynthetic and catabolic activities may mediate some pathological consequences found in obstructive nephropathy.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol / Q000096:biosynthesis / Q000378:metabolism; D006911:Hydroxyprostaglandin Dehydrogenases / Q000378:metabolism; D019746:Intramolecular Oxidoreductases; D007668:Kidney / Q000201:enzymology*; D008026:Ligation; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013930:Thromboxane-A Synthase / Q000378:metabolism; D014513:Ureter / Q000502:physiology; D014517:Ureteral Obstruction / Q000201:enzymology*
D011453:Prostaglandins; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase; D011451:Prostaglandin-Endoperoxide Synthases; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase; D013930:Thromboxane-A Synthase