Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.
The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted fluid contained less protein of plasma origin. Toxin B had no effect on either tissue. Secretory and tissue damaging properties of crude C difficile toxins were found to be due to toxin A.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D003013:Clostridium; D003106:Colon / Q000187:drug effects*; D003603:Cytotoxins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004768:Enterotoxins / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects*; D008297:Male; D010539:Permeability; D011817:Rabbits; D013997:Time Factors
D001427:Bacterial Toxins; D003603:Cytotoxins; D004768:Enterotoxins