Effects of the 1,5-benzodiazepine clobazam on pituitary hormones in the male rat.
The aim of this study is to evaluate the effects of the acute and subchronic administration of the benzodiazepine clobazam (20 mg/kg orally) on the plasma levels of the pituitary hormones (prolactin, FSH and LH) in the male rat. This 1.5 benzodiazepine did not induce any variation of the hormone levels either after acute or subchronic administration. These negative data are discussed as compared to the effects of other benzodiazepines of GABA and GABA receptor agonists and antagonists on the pituitary hormone levels according to particular experimental conditions.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D000078306:Clobazam; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; D000078306:Clobazam; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone