[Effect of nitroprusside, nitroglycerin, propranolol and mannitol on the size of a myocardial infarct].
Effects of nitroprusside, nitroglycerin, propranolol and mannitol on the size of infarcted and peri-infarction areas were examined in 276 patients with acute left-ventricular anterior myocardial infarction. The study involved an assessment of electrocardiograms from 35 precordial leads, and the measurement of central venous blood pressure, hemodynamic parameters, serum enzymes, acid-base state and, in some patients, the pressure inside the pulmonary artery, right and left cavities of the heart and the aorta, left-ventricular kinetocardiography, etc. All the drugs examined were shown to have a favourable effect on the size of the peri-infarction area and reduce the extent of myocardial infarction. Indications for each of the drugs have been worked out on a differential basis. A detailed analysis of ECG patterns from multiple chest leads under the action of nitroprusside, nitroglycerin, propranolol and mannitol is presented.
D006328:Cardiac Catheterization; D004341:Drug Evaluation; D004562:Electrocardiography / Q000379:methods; D005292:Ferricyanides / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007702:Kinetocardiography; D008353:Mannitol / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005996:Nitroglycerin / Q000627:therapeutic use*; D009599:Nitroprusside / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D013997:Time Factors
D005292:Ferricyanides; D009599:Nitroprusside; D008353:Mannitol; D011433:Propranolol; D005996:Nitroglycerin
Vliianie nitroprussida, nitroglitserina, propranolola i mannitola na razmery infarkta miokarda.