Monoclonal B-cell lymphocytosis in early childhood. A case report.
A case is reported of a 12-year-old girl with a benign course of a lymphocytosis through years associated with splenomegaly. The lymphocytes simultaneously expressed a monoclonal B-cell phenotype of IgM-kappa and a mature T-antigen using the monoclonal OKT1 antibody. Due to her stable condition, no treatment was required. The immunological results suggest the possibility of an early childhood B-cell chronic lymphoid leukemia.
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology*; D002648:Child; D002999:Clone Cells; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology; D008218:Lymphocytosis / Q000473:pathology*; D011289:Preleukemia / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D013163:Splenomegaly
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D011947:Receptors, Antigen, B-Cell