A chromosomal study on blood lymphocytes of patients poisoned by polychlorinated biphenyls.
Chromosome studies were carried out on peripheral blood lymphocytes from 36 PCB-poisoned patients and on ten PCB-unexposed healthy controls. Nineteen out of 36 patients (52.7%) had either chromosome or chromatid aberrations, while none of the controls had. The highest percentage of cells with chromosome or chromatid aberrations in a single individual was 34.0. The blood PCB level ranged from 6.4 to 101.8 ppb, with a mean of 34.1 ppb. No correlation was observed between the level of blood PCB and the presence or absence of chromosome or chromatid aberrations.
D000293:Adolescent; D000328:Adult; D000375:Aging; D002648:Child; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D012737:Sex Factors
D011078:Polychlorinated Biphenyls