Plasma cells in acute hepatitis: an ultrastructural study.
Plasma cells and their precursors were studied by electron microscopy in liver biopsies from 41 patients with acute viral or drug-induced hepatitis. Mature plasma cells showed the ultrastructural features of the reticular or lymphatic type. Blast cells of different types were also observed. Type 1 predominated in classical acute hepatitis, and appears to transform directly into mature plasma cells. Type 2 corresponds to the centroblast of lymphoid tissue. It was found in fully developed hepatitis, especially when necrosis was severe. Type 3 resembled the centrocyte of lymphoid organs; it was seen particularly in viral hepatitis, and only in severe cases with extensive necrosis. The type 4 plasmablast had the ultrastructural characteristics of a plasmacytoid T cell.
D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D010950:Plasma Cells / Q000648:ultrastructure*