Potential role of arachidonic acid metabolites in hypoxic pulmonary vasoconstriction.
Hypoxic vasoconstriction is important for lung ventilation/perfusion matching. The mechanism of hypoxic vasoconstriction remains elusive. Arachidonic acid is released from hypoxic tissues; possibly vasoconstricting arachidonate metabolites are involved in hypoxic pulmonary vasoconstriction. Data are presented that consider (a) lipoxygenase product(s) as "local," which could be involved in the hypoxia induced pulmonary vasoconstriction.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008084:Lipoxygenase / Q000378:metabolism; D008168:Lung / Q000098:blood supply; D008171:Lung Diseases / Q000378:metabolism*; D014661:Vasoconstriction
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D008084:Lipoxygenase