A model of brain abscess: septic homologous blood clot emboli in rats.
Brain abscesses in rats were produced by intra-arterial injection of septic homologous blood clot emboli. The production rate was 100% and the histopathological features closely resembled those seen in other animal models and in spontaneously occurring brain abscesses in humans. This small-animal model may be useful for systematic study of the development of brain abscesses as well as for evaluation of various therapeutic procedures.
D000038:Abscess / Q000209:etiology / Q000473:pathology*; D000818:Animals; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology*; D002542:Intracranial Embolism and Thrombosis / Q000150:complications; D008297:Male; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000150:complications / Q000473:pathology