title: [Intracavitary high dose rate afterloading irradiation of inoperable malignant bile duct obstruction].
abstract: After decompression of the bile duct with PTCD, seven patients with carcinomas of the bile ducts were submitted to an intracavitary Ir-afterloading irradiation performed according to the high-dose-rate method with a Buchler device. Most of the patients were irradiated with 30 Gy in two fractions. Five patients were also exposed to percutaneous radiation with 40 to 50 Gy. Local control was achieved in six patients. One patient developed a locoregional recurrence which was possibly due to a so-called "geographic miss". In one patient a benign fibrotic stenosis of the bile duct was found at the site of most intensive irradiation. Intracavitary irradiation is very important in the treatment of malignant obstruction of bile ducts. However, there is an urgent need of research with regard to the combined method with percutaneous irradiation and to the optimum fractionation of intracavitary high dose rate irradiation.
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D002779:Cholestasis / Q000601:surgery; D004322:Drainage; D005260:Female; D006801:Humans; D007495:Iridium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011868:Radioisotopes / Q000627:therapeutic use
chemical_list: D011868:Radioisotopes; D007495:Iridium
vernacular_title: Intrakavitäre High-dose-rate-Afterloading-Bestrahlung beim inoperablen malignen Gallengangsverschluss.