Effects of chalcone derivatives on lipoxygenase and cyclooxygenase activities of mouse epidermis.
The effects of chalcone derivatives on 12-lipoxygenase and cyclooxygenase of mouse epidermis were investigated. The chalcone derivatives which have 3,4-dihydroxycinnamoyl structure in the molecule, such as 3,4-dihydroxychalcone, 3,4,2'-trihydroxychalcone, 3,4,4'-trihydroxychalcone and 3,4,2'4'-tetrahydroxychalcone, potently inhibited epidermal 12-lipoxygenase activity. Although some of them also inhibited cyclooxygenase activity at relatively high concentrations, the inhibitory effects of these chalcone derivatives on 12-lipoxygenase were 10 times or more potent than their effects on cyclooxygenase. The chalcone derivatives which have cinnamoyl or 4-hydroxycinnamoyl structure, instead of 3,4-dihydroxycinnamoyl structure, in the molecule, showed little or no inhibitory effects on either 12-lipoxygenase or cyclooxygenase activities. The inhibitory effects of chalcone derivatives on 12-lipoxygenase and cyclooxygenase of mouse epidermis are dependent on the particular structure, i.e. 3,4-dihydroxycinnamoyl structure, of the chalcone derivatives.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002109:Caffeic Acids / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004817:Epidermis / Q000201:enzymology; D005260:Female; D016859:Lipoxygenase Inhibitors; D051379:Mice; D011427:Propiophenones / Q000494:pharmacology*; D011794:Quercetin / Q000494:pharmacology; D012867:Skin / Q000201:enzymology; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D002109:Caffeic Acids; D003373:Coumaric Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011427:Propiophenones; D016718:Arachidonic Acid; D002599:Chalcone; D011794:Quercetin; C004999:ferulic acid; C040048:caffeic acid