Analysis of the genotoxic activity of four N-nitroso compounds by the Drosophila mosaic test.
Mutagenic activity of 4 nitroso compounds of environmental importance - N-nitroso-morpholine, dinitrosopiperazine, N,N'-dinitroso-pyridinol-carbamate and N-methyl-N-nitroso-p-toluenesulfonamide - was tested by the Drosophila mosaic test. Larvae were fed with the nitroso-compound-containing food for 2-4 days, and when they had developed into adults, their wings were screened for mosaic spots. All 4 compounds were positive. This finding supports the conclusion that the mosaic test - besides other test procedures - may become a tool for identifying mutagens.
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics*; D007814:Larva / Q000187:drug effects; D009030:Mosaicism / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods*; D009603:Nitroso Compounds / Q000633:toxicity*
D009603:Nitroso Compounds