[Analysis of the kinetic growth patterns of cultured cells. II. The action of ionizing radiation, an alkylating agent and a low-frequency electromagnetic field].
With the help of the earlier devised model of cultured cell growth kinetics it is shown that the "plateau" level on the growth curve of Chinese hamster cells decreased proportionally to a dose of the agent applied after a short-term treatment by gamma-radiation or by alkylating agent thiophosphamide. The analysis of our own and literature data enabled us to propose that the lowering of the growth curve may testify to the geropromoter character (i.e. manifesting in ageing promoting) of the investigated factor action. As the low-frequency electromagnetic field induces similar changes in the growth curve, it is related (together with both the above factors investigated) to geropromoters.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D005720:Gamma Rays; D013852:Thiotepa / Q000494:pharmacology
D000477:Alkylating Agents; D013852:Thiotepa
Analiz nekotorykh kineticheskikh zakonomernosteĭ rosta kul'tiviruemykh kletok. II. Deĭstvie ioniziruiushcheĭ radiatsii, alkiliruiushchego agents, nizkochastotnogo élektromagnitnogo polia.