title: Growth rate of a peripheral annulus defined by neurotoxic destruction in the goldfish retina.
abstract: Fifteen goldfish of similar size (6.8 cm in body length on the average) were reared in an aquarium (about 22 degrees C) for 5 months after neurotoxic destruction of retinal dopamine (DA) cells with intravitreal injection of 6-hydroxydopamine, and then further for 8 months after destruction of indoleamine-accumulating cells with 5,7-dihydroxytryptamine. By means of a histofluorescence technique for retinal wholemounts, the growth rate and the number of DA cells were estimated for a peripheral annulus which had been well defined by the successive neurotoxic destructions of monoamine-accumulating cells. As the fish grew from 8.4 to 11.6 cm in body length on the average over the 8-month period, the defined peripheral annulus of the retina was found to be enlarged radially by approximately 1.5 X and circumferentially by 1.3 X while the number of DA cells in the annulus remained unchanged.
mesh_terms: D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D003530:Cyprinidae / Q000254:growth & development*; D004298:Dopamine / Q000378:metabolism; D006054:Goldfish / Q000254:growth & development*; D006892:Hydroxydopamines / Q000494:pharmacology; D007211:Indoles / Q000378:metabolism; D008856:Microscopy, Fluorescence; D016627:Oxidopamine; D012160:Retina / Q000254:growth & development* / Q000378:metabolism
chemical_list: D006892:Hydroxydopamines; D007211:Indoles; D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine; D004298:Dopamine