Increased erythrocyte adenosine deaminase activity without haemolytic anaemia.
A 4-fold increase of red blood cell adenosine deaminase (ADA) activity was found in a patient without haemolytic anaemia, but with mild anisopoikilocytosis. High-performance liquid chromatography showed a 40% reduction of adenosine-5'-triphosphate (ATP) while all the other nucleotides were in normal ranges. The patient's parents (first cousins) and a brother displayed the same enzyme activities as the controls. This observation suggests that mild increases of ADA activity is neither a marker for congenital hypoplastic anaemia as previously reported nor associated with haemolytic anaemia.
D000243:Adenosine Deaminase / Q000097:blood*; D000244:Adenosine Diphosphate / Q000097:blood; D000249:Adenosine Monophosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000743:Anemia, Hemolytic / Q000175:diagnosis; D004796:Clinical Enzyme Tests; D004798:Enzymes / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D004913:Erythrocytes, Abnormal / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D009243:NAD / Q000097:blood; D009249:NADP / Q000097:blood; D009700:Nucleoside Deaminases / Q000097:blood*; D012016:Reference Values
D004798:Enzymes; D009243:NAD; D000249:Adenosine Monophosphate; D009249:NADP; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase