Crohn's disease activity: assessment by factor VIII coagulation proteins.
Twenty-eight patients (mean age 13.5 years) with proven Crohn's disease were examined for factor VIII coagulation activity (VIII:C), factor VIII-related antigen (VIII R:Ag), and factor VIII-related ristocetin cofactor activity (VIII R:RCF). The factor VIII coagulation proteins were correlated with disease activity index according to van Hees and were compared with inflammatory parameters such as erythrocyte sedimentation rate, c-reactive protein, and orosomucoid. Among the factor VIII proteins, factor VIII-related protein (VIII R:Ag) correlates best with van Hees disease activity index, orosomucoid, c-reactive protein, and erythrocyte sedimentation rate (p less than 0.001 for all parameters). Since acute phase proteins are produced by liver cells, whereas VIII R:Ag is synthesized by endothelial cells, we postulate that this coagulation factor is highly sensitive in reflecting the inflammatory process in the intestine.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000032:analysis; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000097:blood* / Q000276:immunology; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism
D000941:Antigens; D009961:Orosomucoid; D012709:Serum Albumin; D005169:Factor VIII; D002097:C-Reactive Protein