Pharmacologic treatment of parkinsonian tremor.
The relative efficacy of trihexiphenidyl hydrochloride, amantadine hydrochloride, and low-dose carbidopa-levodopa in reducing parkinsonian tremor was investigated using objective techniques. Trihexiphenidyl and carbidopa-levodopa decreased tremor by greater than 50%. Some patients responded to one drug but not to the other. Amantadine decreased tremor less than 25%. Monotherapy with trihexiphenidyl or carbidopa-levodopa should be the initial treatment for the tremor of Parkinson's disease.
D000547:Amantadine / Q000627:therapeutic use*; D002230:Carbidopa / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D014202:Tremor / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000627:therapeutic use*
D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D014282:Trihexyphenidyl; D000547:Amantadine; D002230:Carbidopa