title: The effect of fluoride on chromosome aberration and sister-chromatid exchange frequencies in cultured human lymphocytes.
abstract: Sodium fluoride, at concentrations of up to 60 times the level normally used in drinking water for the prevention of dental decay, was compared with 2 other inorganic salts for its ability to induce chromosome aberrations and sister-chromatid exchanges (SCE) in cultured human lymphocytes. No significant increases in the frequencies of aberrations of SCEs were found.
mesh_terms: D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D005459:Fluorides; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D017680:Potassium Compounds; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology*
chemical_list: D008937:Mitomycins; D017680:Potassium Compounds; D012965:Sodium Chloride; D016685:Mitomycin; D012969:Sodium Fluoride; C033320:potassium fluoride; D005459:Fluorides; D011188:Potassium