Differentiation of fluorinated quinolone antibacterials with Neisseria gonorrhoeae isolates.
Clinical isolates of Neisseria gonorrhoeae were tested for growth inhibition by various quinolones. One acrosoxacin-resistant isolate was also resistant to several fluorinated quinolones with 7-heterocyclic substitution, but, inhibitory concentrations were not elevated for quinolones substituted with a methyl group in the corresponding position (nalidixic acid:position 7, S-25930:position 8) or unsubstituted (flumequine:position 8). Isolates resistant to flumequine demonstrated elevated inhibitory concentrations for all quinolones examined.
D000900:Anti-Bacterial Agents; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000254:growth & development; D011804:Quinolines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011804:Quinolines