Comparison of the vascular permeability of the brain and the spinal cord to mannitol and inulin in rats.
The kinetics of the movement of [14C]mannitol and [14C]inulin from the blood into the CNS of the rat were measured. The spinal cord was found to have a higher permeability to these two substances than the brain. It is likely that the channels through which the tracers diffused are larger in the capillaries of the spinal cord than those in the brain.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002199:Capillary Permeability; D007444:Inulin / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000378:metabolism*
D008353:Mannitol; D007444:Inulin