Effects of suxamethonium on CO2-production.
Eighteen patients undergoing alloplastic surgery of the hip were divided into three groups, each consisting of six patients. All operations were performed under endotracheal intubation using halothane N2O-O2 anaesthesia. After a steady state as to CO2-production had been obtained, suxamethonium 1 mg kg-1 was given intravenously to the patients in Group I. A maximum rise in CO2-production of 14.8% (range: 12.9-16.8) was observed after 5 min. In Group II, patients were pretreated with pancuronium 0.01 mg kg-1: no increase in CO2-production was observed. The third group received a continuous infusion of suxamethonium. In this group there was an increase in CO2-production of 17.6% (range: 6.7-22.0) 5 min after start of infusion. The CO2-production then fell to the preinfusion level over the next 10 min.
D000328:Adult; D000368:Aged; D000770:Anesthesia, Endotracheal; D002245:Carbon Dioxide / Q000378:metabolism*; D005260:Female; D006221:Halothane; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D009609:Nitrous Oxide; D010197:Pancuronium / Q000494:pharmacology; D013268:Stimulation, Chemical; D013390:Succinylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D002245:Carbon Dioxide; D013390:Succinylcholine; D010197:Pancuronium; D009609:Nitrous Oxide; D006221:Halothane