Properties of mouse leukemia viruses: XX. Variation of AKR Substrains in response to antibody therapy.
In previous reports in this series, we have demonstrated that treatment of young AKR mice with IgG prepared against the viral envelope glycoprotein suppresses the development of spontaneous leukemia. Moreover, animals exhibiting high anti-viral antibody titers can transfer protection to their offspring. In this report we have extended the studies to another strain of AKR mice and find that the ability to transfer protection to offspring was not obtained. Foster nursing experiments were therefore conducted and their outcomes are indicative that maternal factors may be responsible for this phenomenon.
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage; D007116:Immunization, Passive; D007942:Leukemia, Experimental / Q000628:therapy*; D051379:Mice; D008806:Mice, Inbred AKR / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology
D000914:Antibodies, Viral; D014759:Viral Envelope Proteins