Comparison of the structure of turtle pancreatic ribonuclease with those of mammalian ribonucleases.
There are 33 invariant amino acid positions out of 132 positions in 42 investigated sequences of ribonucleases from a number of mammalian species and a reptile (snapping turtle, Chelydra serpentina). These invariant residues are unequally distributed over 3 different parts of the molecule. The lobe of the S-protein part of the molecule, which lacks one disulfide bridge and has two shortened loops in turtle ribonuclease, has the lowest percentage of invariant residues, although the active-site residue His 119 is located in this part.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004722:Endoribonucleases / Q000302:isolation & purification; D046911:Macromolecular Substances; D010446:Peptide Fragments / Q000302:isolation & purification; D011487:Protein Conformation; D012260:Ribonucleases / Q000302:isolation & purification; D013045:Species Specificity; D014426:Turtles
D046911:Macromolecular Substances; D010446:Peptide Fragments; C023560:ribonuclease S-peptide; D004722:Endoribonucleases; D012260:Ribonucleases; C032523:ribonuclease SPL