Correlation between outer-membrane lysis and susceptibility of mitochondria to inhibition by adriamycin and polyamines.
Pretreatment of rat liver mitochondria with digitonin or osmotic shock increases their susceptibility to respiratory inhibition by adriamycin and polyamines. Since enhanced inhibitor sensitivity coincides in each case with lysis of the mitochondrial outer membranes, the possibility is raised that this membrane represents a permeability barrier to certain polar, organic cations.
D000818:Animals; D002412:Cations; D004072:Digitonin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects*; D009994:Osmolar Concentration; D010539:Permeability; D011073:Polyamines / Q000494:pharmacology*; D051381:Rats; D013095:Spermidine / Q000494:pharmacology; D013096:Spermine / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents
D002412:Cations; D011073:Polyamines; D013386:Succinates; D014475:Uncoupling Agents; D013096:Spermine; D004317:Doxorubicin; D004072:Digitonin; D013095:Spermidine