title: Presence of colonization factor antigens on fresh isolates of fecal Escherichia coli: a prospective study.
abstract: In Dhaka, Bangladesh, fresh isolates of Escherichia coli from 197 patients with diarrhea were investigated for production of enterotoxin and possession of colonization factor antigen (CFA) I or II. Enterotoxigenic E. coli (ETEC) was isolated from 34% of the patients, and of the 67 enterotoxin-positive strains, 75% carried CFAs. Among 68 healthy control persons no strains positive for both enterotoxin and CFA were found. The CFAs in general were restricted to certain serotypes of E. coli. In a subgroup of patients, part of an ongoing surveillance study, mixed infection was seen in 23% of those from whom recognized pathogens were identified. There was a tendency to more severe dehydration when the two virulence factors, enterotoxin and CFA, were simultaneously present.
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis*; D001427:Bacterial Toxins / Q000096:biosynthesis; D003681:Dehydration / Q000382:microbiology; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology; D004768:Enterotoxins / Q000096:biosynthesis; D004926:Escherichia coli / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D029968:Escherichia coli Proteins; D005243:Feces / Q000382:microbiology*; D036781:Fimbriae Proteins; D006386:Hemagglutination Tests; D006801:Humans; D005779:Immunodiffusion; D011446:Prospective Studies; D012703:Serotyping
chemical_list: D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C022924:colonization factor antigens; C034151:heat stable toxin (E coli); D036781:Fimbriae Proteins; C027538:heat-labile enterotoxin, E coli