[Serum concentration of glyceryl trinitrate (GTN) in transdermal application of GTN dressings of various origins].
Serum levels of glyceryl trinitrate have been determined in eight healthy subjects following transdermal application of four different glyceryl trinitrate plasters using a randomised crossover design. The plasters investigated were Deponit 10, Nitradisc 10, Nitroderm TTS 10 and Nitro-Pflaster-ratiopharm 10. The medians of serum concentrations arranged in decreasing order were 0.17-0.23 ng/ml for Nitroderm TTS 10, 0.13-0.21 ng/ml for Nitradisc 10, 0.08-0.13 ng/ml for Deponit 10, and 0.04-0.09 ng/ml for Nitro-Pflaster-ratiopharm 10. Corresponding areas under the concentration-time curves (AUC 0-24) were 23.15 nmol . h/l (Nitroderm TTS), 20.32 nmol . h/l (Nitradisc), 10.39 nmol . h/l (Deponit), and 5.7 nmol . h/l (Nitro-Pflaster-ratiopharm).
D000287:Administration, Topical; D000328:Adult; D001458:Bandages; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000097:blood*; D013810:Therapeutic Equivalency
D005996:Nitroglycerin
Serumkonzentration von Glyceroltrinitrat (GTN) bei transdermaler Applikation von GTN-Pflastern unterschiedlicher Provenienz.