Immunogenicity and protective effect of hemolysis mutants of Mycoplasma pneumoniae.
Two attenuated strains of Mycoplasma pneumoniae, P24-S1 and P24-S11, were tested for their ability as a live vaccine to confer on hamsters immune resistance against challenge infection with a virulent strain of M. pneumoniae, FH-P24. Fifty percent protection was obtained by vaccination with the P24-S1 strain administered once or twice. In contrast, only 10% of the animals were protected by the P24-S11 vaccine even when it was given three times. Vaccination with the P24-S1 strain resulted in higher humoral and cellular immune responses than the P24-S11 did. These results suggest that the P24-S1 strain has the primary qualities a vaccine which may be used for protection against human mycoplasmal infection.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D006224:Cricetinae; D006461:Hemolysis; D008168:Lung / Q000382:microbiology; D008297:Male; D008647:Mesocricetus; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D011019:Pneumonia, Mycoplasma / Q000276:immunology / Q000517:prevention & control*; D014132:Trachea / Q000382:microbiology; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated