Ovarian hyperstimulation due to long-term pulsatile intravenous GnRH treatment.
Pulsatile long-term gonadotropin releasing hormone (GnRH) therapy with an average dosage of 8 micrograms/pulse i.v. in intervals of 90 min induced in a patient with hypothalamic amenorrhea the development of multiple ovarian cysts as visualized by ultrasonography. Estradiol (E2) plasma concentration reached values of 5000 pg/ml. These findings indicate that pulsatile GnRH application can induce ovarian hyperstimulation.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007263:Infusions, Parenteral; D007986:Luteinizing Hormone / Q000097:blood; D010048:Ovarian Cysts / Q000139:chemically induced*; D010053:Ovary / Q000187:drug effects; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D010906:Pituitary Hormone-Releasing Hormones; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone