Clonal abnormalities in patients with Waldenström's macroglobulinemia with special reference to a Burkitt-type t(8;14).
Clonal chromosome changes have been found in two patients with Waldenström's macroglobulinemia (WM). In one, the changes were only numerical: trisomy 3, trisomy 18, and monosomy 21. In the other, both numerical and structural changes were observed, among which t(8;14) with breakpoints (q24;q32), similar to those found in Burkitt's lymphoma, was the most relevant. This association between a new lymphoproliferative process and the Burkitt-type t(8;14) is stressed.
D000368:Aged; D000782:Aneuploidy; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic; D014314:Trisomy; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*