Protein and amino acid metabolism after severe cerebral trauma.
Fourteen patients (20-48 years) suffering from severe head injury were followed for changes in amino acid and protein metabolism during the first 8 days after trauma. All patients received a standardized intravenous nutrition containing 15.7 g of nitrogen per day and additional carbohydrates. Electrolytes, free water, and blood constituents were given as needed. Additional treatment included surgical decompression of space-occupying hematomas, high dose dexamethasone therapy, and controlled hyperventilation for at least 5 days. Gross changes of protein metabolism were observed particularly on the days 5 and 6. The duration and chronological sequence of these changes are different from those usually found in patients with multiple injuries.
D000328:Adult; D000596:Amino Acids / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000628:therapy; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition; D011506:Proteins / Q000378:metabolism*; D013997:Time Factors
D000596:Amino Acids; D001798:Blood Proteins; D011506:Proteins; D009584:Nitrogen