title: Selective consumption of large platelets during massive bleeding.
abstract: To see whether selective consumption of either small or large platelets occurs during haemostasis in vivo the mean platelet volume was studied in six patients who developed thrombocytopenia after trauma. The mean platelet volume at the onset of thrombocytopenia was significantly lower than that on admission (p less than 0.01): selective loss of large platelets had occurred.
mesh_terms: D001792:Blood Platelets; D006470:Hemorrhage / Q000097:blood*; D006487:Hemostasis; D006801:Humans; D010974:Platelet Aggregation; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood* / Q000209:etiology; D013997:Time Factors; D014947:Wounds and Injuries / Q000150:complications