title: [Mutation process and malignant transformation induced by adenoviruses in mammalian cells].
abstract: Both oncogenic adenovirus (BAV-3) and nononcogenic adenovirus (Ad-1) are able to induce gene mutations in cultured mammalian cells. In the case of equal multiplicity of the infection the frequency of induced mutations is higher in variants with Ad-1. Unlike Ad-1 both mutagenic and transforming effects of BAV-3 are intensified by means of TPA promoters. TPA modifies analogously mutagenic and transforming effect of much less than oncogenic fragment much greater than of DNA BAV-3. Oncogene and, probably, other viral genes reveal mutagenic activity.
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000260:Adenoviruses, Human / Q000235:genetics; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002472:Cell Transformation, Viral / Q000187:drug effects; D002478:Cells, Cultured; D003043:Cocarcinogenesis; D006224:Cricetinae; D003412:Cricetulus; D004279:DNA, Viral / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014162:Transfection
chemical_list: D004279:DNA, Viral; D013755:Tetradecanoylphorbol Acetate
vernacular_title: Mutatsionnyĭ protsess i zlokachestvennaia transformatsiia, indutsirovannye adenovirusami v kletkakh mlekopitaiushchikh.