title: Aneuploidy in the embryonic progeny of females heterozygous for the Robertsonian chromosome (9.12) in genetically wild Peru-Coppock mice (Mus musculus).
abstract: The spontaneous appearance of a Robertsonian translocation in a laboratory colony of genetically wild Peru-Coppock mice gave the opportunity to study potential meiotic nondisjunction soon after the formation of the new chromosome and also in a hitherto untested combination of genotype and environment Metaphase II scores from the progenitor male had indicated a nondisjunction rate of approximately 10%, a figure that was confirmed by the finding of an estimated 12-16% total trisomic and probable monosomic zygotes in chromosomal studies of Day 9 embryos from heterozygous females. The chromosome studies also showed the presence of a significant excess of normal embryos that were heterozygous for the Robertsonian chromosome.
mesh_terms: D000782:Aneuploidy; D000828:Animal Population Groups / Q000235:genetics*; D000818:Animals; D000835:Animals, Wild / Q000235:genetics*; D001755:Blastocyst / Q000502:physiology; D005260:Female; D006579:Heterozygote; D007621:Karyotyping; D008677:Metaphase; D051379:Mice / Q000235:genetics*; D011247:Pregnancy; D014178:Translocation, Genetic