Depression by slime-extract from Pseudomonas aeruginosa of delayed type hypersensitivity to sheep erythrocytes.
High doses of slime-extract from Pseudomonas aeruginosa was found to suppress the delayed type hypersensitivity response to sheep erythrocytes when administered intraperitoneally 1 to 3 days before or 3 days after intravenous sensitization of mice. Moreover, the spleen cells from sensitized and slime-extract treated mice transferred the depression to normal recipients. Inhibition of DTH response was also seen when recipients were injected with slime-extract 24 h before they were infused with spleen cells from donor mice immunized with sheep erythrocytes. The development of skin DTH was quantitated by footpad increase. The data suggest that slime-extract from P. aeruginosa induces in spleens of mice immunosuppressive cells which affect the immunization with sheep red blood cells.
D000818:Animals; D004912:Erythrocytes / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D007116:Immunization, Passive; D051379:Mice; D008815:Mice, Inbred Strains; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012756:Sheep