Prophylaxis of Pseudomonas aeruginosa infections in leukopenic mice by a combination of active and passive immunization.
Mice rendered leukopenic with cyclophosphamide and then challenged with viable Pseudomonas aeruginosa were used to determine the protective efficacy of active immunization against exotoxin A and of passive immunization with human antiserum to Escherichia coli J5, a rough mutant of Escherichia coli O111:B4. Neither treatment alone provided a greater degree of protection than its respective control. However, the combination of these treatments produced a moderate, yet consistent, increase in the survival of infected immunosuppressed mice.
D036002:ADP Ribose Transferases; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001427:Bacterial Toxins; D003520:Cyclophosphamide; D004926:Escherichia coli / Q000276:immunology; D005098:Exotoxins / Q000276:immunology; D007114:Immunization; D007116:Immunization, Passive; D007970:Leukopenia / Q000139:chemically induced / Q000150:complications / Q000382:microbiology*; D051379:Mice; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
D036002:ADP Ribose Transferases; D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D003520:Cyclophosphamide; D005098:Exotoxins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A