Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice.
Polyclonal and monoclonal antibodies with specificity for protein Mx (a karyophilic 75,000-dalton protein induced by interferon [IFN] in mouse cells carrying the influenza virus resistance allele Mx+) detected an IFN-induced 80,000-dalton protein in peripheral blood lymphocytes and in fibroblasts of healthy human donors. The human protein, like protein Mx, was induced by IFN-alpha but not by IFN-gamma. Unlike the mouse protein, it was predominantly localized in the cell cytoplasm.
D000483:Alleles; D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000998:Antiviral Agents; D002460:Cell Line; D005260:Female; D019204:GTP-Binding Proteins; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology; D008168:Lung / Q000196:embryology; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D064547:Myxovirus Resistance Proteins; D009975:Orthomyxoviridae / Q000276:immunology*; D011247:Pregnancy; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000998:Antiviral Agents; D007370:Interferon Type I; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D007371:Interferon-gamma; D019204:GTP-Binding Proteins