Comparison of inhibitory effects of atropine, cimetidine, and atropine plus cimetidine on the indomethacin-provoked gastric mucosal erosions in rats.
20 mg/kg-1 indomethacin suspended in 1% carboxymethyl-cellulose solution was given subcutaneously into rats to provoke gastric mucosal erosions during 5 h. Dose-dependent inhibitions of indomethacin erosions were observed following different doses of atropine (0.025; 0.2; 1.0 mg/kg-1) and cimetidine (2.5; 10; 50 mg/kg-1) administered intraperitoneally (25%; 38%; 81% and 0%; 42%; 89% respectively). More pronounced inhibitory effects have been obtained with the combinations of both drugs (51%; 68%; 92%). In particular there was a remarkable potentiated synergism in the lowest doses of atropine and cimetidine (51%, against 0% and 25%). These results provide further evidence of synergism of histamine H2-receptor blockers and anticholinergics, which combinations would be useful, for example, in peptic ulcer therapy.
D000818:Animals; D000897:Anti-Ulcer Agents; D001285:Atropine / Q000008:administration & dosage* / Q000494:pharmacology*; D002927:Cimetidine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000037:antagonists & inhibitors; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*
D000897:Anti-Ulcer Agents; D001285:Atropine; D002927:Cimetidine; D007213:Indomethacin