Serological failure of Pseudomonas vaccination in patients receiving multiple chemotherapy.
Patients undergoing induction chemotherapy for malignant disease were immunized with a polyvalent Pseudomonas vaccine using a three or four dose schedule. A control group was immunized with a two dose schedule. Despite the more intensive administration of vaccine to the patients they produce a markedly subnormal and brief antibody response. A large clinical trial of this vaccine in patients with cancer seems unjustified in light of these data.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
D000907:Antibodies, Bacterial; D000970:Antineoplastic Agents; D001428:Bacterial Vaccines