[Hypotension induced by molsidomine or trinitroglycerin].
Molsidomine--a new vasodilator agent with predominant venous effect--is used for the treatment of coronary artery disease. Haemodynamic effects of i.v. molsidomine (300 micrograms X kg-1) during deliberate hypotension were investigated in 11 dogs and compared with nitroglycerin-induced-hypotension, at the same decrease in MAP (-25%). Hypotension was only obtained in 5 dogs with both drugs. Hypotension resulted from decrease in stroke volume due to a decrease in preload. Decrease in systemic vascular resistance and tachycardia were less important with molsidomine than with nitroglycerin. After molsidomine MAP decreased progressively over 30 minutes.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007022:Hypotension / Q000139:chemically induced*; D008981:Molsidomine; D005996:Nitroglycerin / Q000494:pharmacology*; D010069:Oxadiazoles / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects; D013558:Sydnones / Q000494:pharmacology*; D013610:Tachycardia / Q000139:chemically induced; D014655:Vascular Resistance / Q000187:drug effects
D000959:Antihypertensive Agents; D010069:Oxadiazoles; D013558:Sydnones; D008981:Molsidomine; D005996:Nitroglycerin
Hypotension provoquée par molsidomine ou trinitroglycérine.