2'-Chloropentostatin: discovery, fermentation and biological activity.
2'-Chloropentostatin (2-CP) is a new nucleoside antibiotic produced by Actinomadura sp. ATCC 39365. A selectively sensitive assay organism, Enterococcus faecalis PD 05045 (MIC 0.005 micrograms/ml) was instrumental in the discovery of this compound. 2-CP is a tight-binding inhibitor of adenosine deaminase (Ki = 1.1 X 10(-10) M).
D000192:Actinomycetales / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001681:Biological Assay; D003070:Coformycin / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D005285:Fermentation; D009705:Nucleosides; D015649:Pentostatin / Q000031:analogs & derivatives*; D014740:Vidarabine / Q000494:pharmacology
D058892:Adenosine Deaminase Inhibitors; D000900:Anti-Bacterial Agents; D009705:Nucleosides; D003070:Coformycin; D015649:Pentostatin; C046686:adechlorin; D014740:Vidarabine