[Significance of urothelial dysplasia in macroscopically normal mucosa in patients with bladder tumors. Results of a randomized study with and without intravesical mitomycin C in the prevention of recurrence].
During endoscopic treatment of 90 patients with bladder tumors, multiple random biopsies were carried out on normal looking bladder mucosa. Dysplasias were found in 25.6% of the patients. These findings are almost identical to the results of histological examination of bladder in autopsies. Postoperatively, a randomized prophylactic Mitomycin instillation therapy was carried out. Although the recurrence rate under Mitomycin treatment was significantly lower here than in the control group (18.8% vs. 56.7%), the rate of dysplasias was nearly twice as high as in the control group (43.8% vs. 23.3%). Therefore, the conclusion can be drawn that dysplasia only reflects the present picture of proliferative activity of urothelium, but allows no interpretation of biological activity or prognosis of bladder carcinoma.
D000368:Aged; D001706:Biopsy; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D009092:Mucous Membrane / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011182:Postoperative Care; D011379:Prognosis; D011897:Random Allocation; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D008937:Mitomycins; D016685:Mitomycin
Stellenwert der Urotheldysplasien in makroskopisch normaler Schleimhaut bei Patienten mit Blasentumoren. Ergebnis einer randomisierten Studie mit und ohne intravesikaler Mitomycin-C-Rezidivprophylaxe.