Components of attention, methylphenidate dosage, and blood levels in children with attention deficit disorder.
In this study we analyzed some of the cognitive components that may constitute attention deficit disorder. It consisted of a double-blind, drug-placebo study of 12 children being treated with three doses of methylphenidate and placebo. Results of an attentional test battery, teacher and parent ratings, and blood levels of methylphenidate are reported. In general, performance was best with 0.6 mg/kg of methylphenidate (the highest dose tested) and worst with placebo. It is argued that no single test provides a complete assessment of attentional deficits and that methylphenidate can improve performance by affecting the allocation of cognitive resources to a task.
D000293:Adolescent; D001288:Attention / Q000187:drug effects*; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects; D007206:Individuality; D008297:Male; D008568:Memory / Q000187:drug effects; D008774:Methylphenidate / Q000008:administration & dosage* / Q000097:blood; D011932:Reading
D008774:Methylphenidate