[Incorporation of the protective antigen of Brucella abortus into liposomes and the immunogenic properties of the antigen-containing liposomes].
The incorporation of B. abortus protective antigen into liposomes and its localization in liposomes have been found to depend on the lipid composition of liposomes. After the injection of the protective antigen conjugated with negatively charged liposomes humoral response is more pronounced than after the injection of the protective antigen incorporated into neutral liposomes. The immunization of guinea pigs with antigen-containing liposomes ensures the production of "incomplete antibodies" in the animals in high titers.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000032:analysis / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology*; D003298:Coombs Test; D006168:Guinea Pigs; D007114:Immunization; D008055:Lipids / Q000032:analysis / Q000276:immunology; D008081:Liposomes / Q000032:analysis / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D008055:Lipids; D008081:Liposomes
Vkliuchenie protektivnogo antigena Brucella abortus v liposomy i immunogennye svoĭstva antigensoderzhashchikh liposom.