I-J expression is not associated with murine chromosome 4.
I-J originally mapped within the murine major histocompatibility complex (H-2) between the EB and Ea loci using intra-H-2 recombinants. Cloning of this segment of H-2 shows no DNA that can be ascribed to I-J. Various hypotheses have attempted to explain this dilemma. One hypothesis attributes a chromosome 4 locus with I-Jk expression. This hypothesis requires the AKR/J and A/WySn mouse strains to be I-Jk negative. In the present report we show that AKR/J spleen cells express I-Jk surface molecules and that both the AKR/J and A/WySn mouse strains produce functional I-Jk-bearing suppressor factors to poly(Glu50Tyr50). Our data imply that mapping of I-J-determining genes to chromosome 4 may be premature.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002874:Chromosome Mapping; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D013154:Spleen / Q000166:cytology
D000954:Antigens, Surface; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II