title: Hyperinflammatory proliferative (blastomycosis-like) pyodermas: review, mechanisms, and therapy.
abstract: Some sites of chronic localized infection have a vigorous granulocytic inflammatory response and develop marked tissue proliferation. This is most common in patients with poor nutrition, halogen ingestion or foreign bodies. The granulocytes release connective tissue-activating peptides which cause fibroblast proliferation and ground substance formation. The dermal papillae enlarge and support a larger germinative cell volume, producing pseudoepitheliomatous hyperplasia. Hypertrophic granulation tissue or "proud flesh" appears to be a similar phenomenon without the epithelial component. In a milder physiologic range this phenomenon probably accounts for the term "laudable pus."
mesh_terms: D001759:Blastomycosis; D003475:Curettage; D003646:Debridement; D062109:Dermatologic Surgical Procedures; D005347:Fibroblasts / Q000201:enzymology; D006025:Glycosaminoglycans / Q000096:biosynthesis; D006801:Humans; D007249:Inflammation; D009504:Neutrophils / Q000201:enzymology; D011711:Pyoderma / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D012867:Skin / Q000382:microbiology / Q000473:pathology
chemical_list: D006025:Glycosaminoglycans