Effects of ranitidine and cimetidine on plasma lipoproteins in healthy subjects.
Serum lipoproteins were monitored in 24 healthy subjects receiving either ranitidine or cimetidine for four weeks. Ranitidine produced a significant (P less than .05) reduction in high-density lipoprotein (HDL)-cholesterol in both men and women. Cimetidine caused a nonsignificant increase in HDL-cholesterol and a reduction in LDL-cholesterol that was significant (P less than .05) only in women. As these drugs had opposite effects on HDL-cholesterol levels, the mechanism of action is unlikely to be medicated by H2-receptor blockade.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D002927:Cimetidine; D011899:Ranitidine