[Valinomycin biosynthesis and the dynamics of the content of macroergic phosphorus compounds in Streptomyces cyaneofuscatus].
The pattern of accumulation and consumption of macroergic phosphoric compounds such as polyphosphates, pyrophosphate and ATP in the mycelium of the valinomycin-producing organism was studied. The content of high polymeric polyphosphates in the high productive strain A of S. cyaneofuscatus was much lower than that in the isogenic low productive strain B, which was indicative of their participation in providing bioenergetics of antibiotic production. Cultivation of the low productive strain B in the presence or absence of the A-factor showed that the mutant reduced its sporulation and provided a 40-fold increase in biosynthesis of valinomycin. However, no difference in consumption of diverse polyphosphate fractions was observed.
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D003470:Culture Media / Q000378:metabolism; D004734:Energy Metabolism; D006133:Growth Substances / Q000378:metabolism; D046911:Macromolecular Substances; D009154:Mutation; D011122:Polyphosphates / Q000032:analysis / Q000378:metabolism*; D013302:Streptomyces / Q000032:analysis / Q000378:metabolism*; D014634:Valinomycin / Q000096:biosynthesis*
D003470:Culture Media; D006133:Growth Substances; D046911:Macromolecular Substances; D011122:Polyphosphates; D014634:Valinomycin; C025035:A-factor (Streptomyces); D015107:4-Butyrolactone
Biosintez valinomitsina i dinamika soderzhaniia makroérgicheskikh fosfornykh soedineniĭ u Streptomyces cyaneofuscatus.