title: Monotherapy and polytherapy for intractable epilepsies.
abstract: A retrospective survey on 66 adults with epilepsy who received multiple drug therapy after the failure of single drugs showed: a reduction of seizure frequency of 75% or more in 16.5%, no change in 67% and an increase in seizure frequency of 100% or more in 16.5%. Multiple drug therapy is of limited value in severe epilepsies.
mesh_terms: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use; D002220:Carbamazepine / Q000627:therapeutic use; D000078306:Clobazam; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D011324:Primidone / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D011324:Primidone; D000078306:Clobazam; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital