title: The importance of brain serotonergic receptor mechanisms for the action of antidepressant drugs.
abstract: The present studies have shown that chronic antidepressant treatment with different types of antidepressant drugs results in adaptive changes in postsynaptic 5-HT receptor mechanisms which appear to result in 5-HT sub- or supersensitivity development depending upon the 5-HT nerve terminal system analyzed. The results underline the heterogeneity of the central 5-HT neuron systems in their responses to chronic antidepressant treatment. In addition, a number of antidepressant drugs have potent, direct actions on 5-HT2 receptors, which may be of clinical relevance.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D008134:Long-Term Care; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D013569:Synapses / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D011985:Receptors, Serotonin; D012701:Serotonin; D011388:Prolactin; D003345:Corticosterone; D009638:Norepinephrine