Rapid rejection of fetal chick neocortical xenografts into the spinal cord of adult rats.
Xenografts of embryonic day 5 chick cortex were placed into the dorsal column of the spinal cord of 15 adult male Sprague-Dawley rats. This implantation site is known to support comparable E11 rat cortex for months. At 1 DPI (day postoperative), transplanted chicken cortex formed neuroepithelia with a surround of transplanted cells. By 3 DPI, all transplanted cells contained cytoplasmic lipid droplets or lysosomes, as well as necrotic cells. By 7 DPI, the fetal chicken cortical xenograft had necrosed or was phagocytized. The rapid cross-class xenograft rejection is unique since grafts of various rodent tissues tend to survive in the adult rodent central nervous system.
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology / Q000637:transplantation*; D002642:Chick Embryo; D004848:Epithelium / Q000473:pathology; D006084:Graft Rejection; D008297:Male; D009410:Nerve Degeneration; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology*; D014183:Transplantation, Heterologous