[Sensitivity of the lymphocyte chromosomes of chronic alcoholism patients to mutagenic exposure].
The level of chromosome aberrations induced by mitomycin C and cytosine arabinoside in the cultured lymphocytes from patients with chronic alcoholism is elevated, as compared to that observed in the cultured lymphocytes of healthy persons. A supposition was made that transitory instability of cell genome could cause this phenomenon.
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003561:Cytarabine / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D009153:Mutagens; D003561:Cytarabine; D016685:Mitomycin
Chustvitel'nost' khromosom limfotsitov bol'nykh khronicheskim alkogolizmom k mutagennym vozdeĭstviiam.