Fetal brain implants improve maze performance in hippocampal-lesioned rats.
Hippocampal tissue from day 16 fetal rats was implanted into the damaged hippocampal formation of adults. Significant recovery of the lesion-induced deficit in spatial maze performance was observed, particularly in those animals which showed integration of the implanted fetal tissue with the host hippocampal formation. A two-stage procedure in which 2 weeks or more elapsed between the initial lesion and the implantation resulted in more successful tissue integration and better behavioral recovery.
D000818:Animals; D001927:Brain Diseases / Q000628:therapy; D005333:Fetus; D006624:Hippocampus / Q000637:transplantation*; D007859:Learning Disabilities / Q000628:therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains