Sequential computed tomographic imaging of a transplantable rabbit brain tumor.
The accuracy of CT imaging in evaluating VX-2 tumor growth in the rabbit brain was assessed. CT scanning was performed in 5 outbred New Zealand white male rabbits before and at 4, 7, 9 and 13 (in 3 animals) days after surgical implantation of 3 X 10(5) viable VX-2 tumor cells in the frontoparietal lobes. The CT studies were correlated with gross pathology in each. The tumor was visualized with CT in all 5 rabbits by the 9th day post implantation when the tumor ranged in size from 4-6 X 3-4 X 2-3 mm. Between the 9th and 13th day, the tumor increased 6-fold in two rabbits and 12-fold in the third rabbit. CT is a useful technique to evaluate brain tumor growth in this model and should be valuable in documenting the efficacy of chemotherapy on tumor growth.
D000818:Animals; D001479:Basal Ganglia; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005625:Frontal Lobe; D008297:Male; D009368:Neoplasm Transplantation; D011817:Rabbits; D014057:Tomography, X-Ray Computed