Testing of chloroquine and quinacrine for mutagenicity in Drosophila melanogaster.
To extend the data on the mutagenic effects of intercalating agents in Drosophila melanogaster, chloroquine and quinacrine were tested for the induction of genetic damage in D. melanogaster males. Sex-linked recessive lethals and sex-chromosome loss induction were studied following treatment of adult males using a feeding technique. Our results show that both intercalating compounds increase significantly the frequency of sex-linked recessive lethals, but are unable to induce sex-chromosome loss in male germ cells under the conditions of testing.
D000818:Animals; D002738:Chloroquine / Q000494:pharmacology* / Q000633:toxicity; D004331:Drosophila melanogaster / Q000187:drug effects*; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009152:Mutagenicity Tests; D011796:Quinacrine / Q000494:pharmacology* / Q000633:toxicity; D012729:Sex Chromosome Aberrations / Q000139:chemically induced
D002738:Chloroquine; D011796:Quinacrine