title: The epidemiology of polycythaemia rubra vera in England and Wales 1968-1982.
abstract: The epidemiology of polycythaemia rubra vera (PV) has not been studied extensively in the past. In 1968 PV became subject to cancer registration in England and Wales. The mortality rates and registration rates for PV were abstracted for 1968-1982. The average annual mortality rates were 3.0/million/y (men, 1068 cases) and 2.3/million/y (women, 886 cases), there being no significant increase over the time period. The average annual registration rates were 10.7/million/y (men, 3321 cases) and 6.7/million/y (women, 2207 cases) and showed a large increase from 1968 to 1974 with a stable rate subsequently. This increase was concentrated in the 65+ age groups. The median age of registration was 60--64 y with a peak of mortality and incidence between ages 75 and 84 y. The data suggest some degree of overdiagnosis for PV registrations, however the rates are comparable with those seen in other studies in developed countries. The routine data sources require further validation, but they appear to provide useful information for the study of the epidemiology of PV.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D004739:England; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000453:epidemiology* / Q000401:mortality; D014852:Wales