An amphotericin B-resistant case of rhinocerebral mucor mycosis.
A 51-year-old male patient with diabetes mellitus complicated by ketoacidotic imbalance developed a rhinocerebral mucor mycosis that advanced despite early amphotericin B therapy and extensive surgical intervention. The MIC of amphotericin B for the isolated mucor species was 64 mg/l, meaning that in vitro resistance also existed. Only long-term treatment with ketoconazole (600 mg/day, perorally) was successful in curing the disease.
D000666:Amphotericin B / Q000494:pharmacology*; D001927:Brain Diseases / Q000150:complications / Q000188:drug therapy*; D048909:Diabetes Complications; D016883:Diabetic Ketoacidosis / Q000150:complications; D004352:Drug Resistance, Microbial; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009089:Mucor / Q000187:drug effects; D009091:Mucormycosis / Q000150:complications / Q000188:drug therapy*; D009668:Nose Diseases / Q000150:complications / Q000188:drug therapy*
D000666:Amphotericin B; D007654:Ketoconazole