title: Treatment of presumed prolactinoma by transsphenoidal operation: early and late results.
abstract: Seventy seven patients who were presumed to have a prolactinoma on the basis of biochemical findings underwent transsphenoidal operation between October 1977 and September 1983. Sixty one patients were found to have a microadenoma, and hyperprolactinaemia was cured in 46 of these, amenorrhoea in 39 (80% of those with the symptom), galactorrhoea in 32 (80%), and infertility in 31 (82%). Four of eight patients found to have a macroadenoma were also satisfactorily treated with surgery. Two patients had a lesion other than a prolactinoma, and in six a tumour could not be found at operation; four of these last eight patients had a normal serum prolactin concentration after operation. Recurrent hyperprolactinaemia was rare, occurring in only three patients in the series overall; among the 32 patients followed up for more than five years only two of the 22 whose operation had initially been successful developed recurrent hyperprolactinaemia.
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000601:surgery; D007247:Infertility, Female / Q000209:etiology; D008599:Menstruation Disturbances / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D011183:Postoperative Complications; D011388:Prolactin / Q000378:metabolism*; D012008:Recurrence
chemical_list: D011388:Prolactin