title: Antibacterial activity of temocillin in combination with other beta-lactam antibiotics.
abstract: The antibacterial interactions of temocillin with other beta-lactam antibiotics were tested by the checkerboard combination method in Mueller-Hinton agar against 146 strains of Enterobacteriaceae, 35 Pseudomonas aeruginosa strains, and 35 Staphylococcus aureus strains. Most combinations showed either a moderate degree of synergism or indifference. Strains showing occasional antagonism at a particular proportion of concentrations of the test combination, were found to only be indifferent when the mean index of the fractional inhibition concentration of all checkerboard combinations was calculated.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams; C031367:temocillin