title: Changes in the human visual evoked potential caused by the anticholinergic agent hyoscine hydrobromide: comparison with results in Alzheimer's disease.
abstract: The anticholinergic drug hyoscine hydrobromide produced a slowing of the P2 and N3 components of the flash visual evoked potential (VEP) in young normals but did not affect the pattern reversal VEP. These results, which are similar to those found in Alzheimer's disease, could be explained by an underlying defect of the cholinergic system.
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006801:Humans; D007279:Injections, Subcutaneous; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology*
chemical_list: D012601:Scopolamine; D002795:Choline O-Acetyltransferase