[Neutron activation analysis in modelling the elimination from the kidneys of cis-dichlorodiammineplatinum].
A neutron activation analysis was used for a study of platinum elimination from the kidneys of male rats after administration of cis-DDP at a dose of 7 mg per 1 kg of the animal body mass. The literature data on beagles were taken for comparison. A simple mathematical model for platinum elimination from the kidneys was proposed: the platinum content was 2.27 micrograms per 1 g of raw tissue for the time interval of 3h less than or equal to t less than or equal to 1 day; 2.34 X X t(-0,51) micrograms/g for t greater than 1 day and a dose of 1 mg per 1 kg of the animal body mass. An opportunity to predict the platinum content in the human kidneys was tested.
D000201:Activation Analysis; D000818:Animals; D002945:Cisplatin / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D051381:Rats
D002945:Cisplatin
Neĭtronno-aktivatsionnyĭ analiz v modelirovanii éliminatsii iz pochek preparata tsis-dikhlordiamminplatiny.