Effect of intratracheal injection of zinc oxide dust in guinea pigs.
Intratracheal injection of zinc oxide dust, a component of many cosmetic preparations caused elevation of alkaline phosphatase and lactate dehydrogenase in serum and lung of guinea pigs. Clearance of zinc oxide dust from lungs through zinc-carrying proteins was evident.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004391:Dust / Q000009:adverse effects*; D005260:Female; D066298:In Vitro Techniques; D007267:Injections; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D011485:Protein Binding; D014132:Trachea; D015032:Zinc / Q000633:toxicity*; D015034:Zinc Oxide / Q000378:metabolism / Q000633:toxicity*
D004391:Dust; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase; D015032:Zinc; D015034:Zinc Oxide