Hemolytic disease of the newborn due to anti-C and anti-G masquerading as anti-D.
After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurrence in itself. Moreover, the fetus was affected significantly and was delivered at 32 1/2 weeks with moderate hemolytic disease of the newborn. Consideration is given to points regarding current methods of screening Rh-negative women for transfusion, the use of anti-Rh immune globulin in patients sensitized to anti-C and anti-G, medicolegal implications, and continuous attention to the risk-benefit ratio in decisions to use transfusions.
D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility; D004375:Duffy Blood-Group System / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000209:etiology*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D007567:Jaundice, Neonatal / Q000209:etiology*; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D065227:Transfusion Reaction
D001789:Blood Group Antigens; D004375:Duffy Blood-Group System; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System