title: Changes in histochemical profile of muscle after long-term electrical stimulation in patients with idiopathic scoliosis.
abstract: Adolescent patients with idiopathic scoliosis were treated with long-term electrical stimulation (30 Hz) at the posterior axillary line on the convex side of the curvature in order to correct the spinal deformity. The patients were also followed with muscle biopsies from the latissimus dorsi of the stimulated side taken before, after 3 and 6 months of electrical stimulation. There was a tendency for an increase in the percentage of type I and especially the type II C (undifferentiated) fibers after stimulation. The mean muscle fiber area and the fiber areas of the various fiber types did not change significantly. Histopathological findings were generally rare before as well as after 3 months of electrical stimulation, the only noticeable finding being a somewhat increased frequency of atrophic fibers in groups after 6 months of stimulation. In all studied patients the enzymatic activity of citrate synthase increased after 3 months and further in three studied patients after 6 months of stimulation. The present study gives some evidence of an adaptive process caused by electrical stimulation towards a more fatigue-resistant muscle.
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D001706:Biopsy; D002648:Child; D002950:Citrate (si)-Synthase / Q000378:metabolism; D004599:Electric Stimulation Therapy; D004798:Enzymes / Q000378:metabolism*; D005260:Female; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008134:Long-Term Care; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000473:pathology*; D012600:Scoliosis / Q000201:enzymology / Q000473:pathology / Q000628:therapy*
chemical_list: D004798:Enzymes; D009124:Muscle Proteins; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D002950:Citrate (si)-Synthase; D000263:Adenylate Kinase