Lymphoid nodules and nodular lymphoid hyperplasia in bone marrow biopsies.
Out of 2,474 bone marrow biopsies we have observed 330 cases (13.3%) with presence of lymphoid nodules (LN). LN were frequent in old age (24.6% over 80 years), in females (17%) and in some diseases, such as rheumatoid arthritis and systemic lupus erythematosus (73.7% of the cases), partial aplasia (34%), hypersplenism (30.4%), hemopoietic dysplasia (25%), chronic renal failure (20.4%), polycythemia vera (20.2%), idiopathic thrombocytopenic purpura (18.8%), acute leukemia (17.7%). Nodular lymphoid hyperplasia of the bone marrow was found especially in systemic autoimmune diseases (26.3%), hypersplenism (9.8%), preleukemia (7.3%) and acute leukemia (4.2%). The presence of excessive medullary LN could indicate a bone marrow microenvironment damage, possibly of autoimmune origin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006402:Hematologic Diseases / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000453:epidemiology / Q000473:pathology; D007154:Immune System Diseases / Q000473:pathology; D007223:Infant; D007231:Infant, Newborn; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008875:Middle Aged