title: Hemorrhage from the cosmetic otoplasty of Doberman Pinschers with von Willebrand's disease.
abstract: The hemorrhagic tendencies of 23 Doberman Pinscher pups were observed during cosmetic otoplasty and were ranked by a +1 to +4 grading system (+1 = least hemorrhage, and +4 = most hemorrhage). A second estimate of the hemostatic competencies of these dogs was made by counting the gauze sponges used in the otoplasties. Factor VIII-related antigen concentrations and coagglutinin cofactor concentrations were measured in plasma samples from blood drawn not more than 30 hours before the surgical procedures were done. The factor VIII-related antigen concentrations were between 9% and 147% of the concentration in a normal plasma pool, and the coagglutinin cofactor concentrations were between 1% and 165%, indicating that some of these dogs had von Willebrand's disease. The hemorrhagic tendencies of 12 pups were graded +1. This group had a mean antigen concentration of 75% (min-max, 38% to 147%) and a mean coagglutinin cofactor concentration of 89% (min-max, 42% to 165%). These were significantly greater than the antigen and cofactor concentrations of the grades +2 (n = 5), +3 (n = 3), or +4 (n = 3) dogs. Significant differences were not found when antigen concentrations of the grade +2 dogs (mean, 16%; min-max, 11% to 22%), grade +3 dogs (mean, 13%; 12% to 16%), and grade +4 dogs (mean, 11%; 9% to 12%) were compared with each other, nor were significant differences seen among the coagglutinin cofactor concentrations of the grade +2 dogs (mean, 7%; min-max, 1% to 11%), grade +3 dogs (mean, 6%, 4% to 8%), and grade +4 dogs (mean, 5%; 2% to 9%).(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D000941:Antigens / Q000032:analysis; D004283:Dog Diseases / Q000276:immunology / Q000601:surgery*; D004285:Dogs; D004431:Ear, External / Q000601:surgery*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000662:veterinary*; D007431:Intraoperative Complications / Q000453:epidemiology / Q000662:veterinary*; D008297:Male; D013045:Species Specificity; D013518:Surgery, Plastic / Q000662:veterinary; D014842:von Willebrand Diseases / Q000276:immunology / Q000601:surgery / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII