Increase in skin mast cells following chronic house dust mite exposure.
Application of inhalant allergens in high concentration to the mildly abraded skin of sensitive patients with atopic dermatitis gave rise to eczematous skin responses at 48 h. These lesions, infiltrated by basophils, eosinophils and mononuclear cells, are examples of cutaneous basophil hypersensitivity. Repeated application of allergen induced an increase in skin mast cells by 6 days, the mast cell hyperplasia replacing the earlier basophil infiltration. No electron microscopic evidence of mast cell heterogeneity among the recruited cells was found.
D000287:Administration, Topical; D000328:Adult; D000485:Allergens / Q000008:administration & dosage*; D002465:Cell Movement; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000150:complications*; D003877:Dermatitis, Contact / Q000209:etiology / Q000473:pathology*; D004391:Dust; D005260:Female; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000502:physiology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D008925:Mites / Q000276:immunology*
D000485:Allergens; D004391:Dust