title: [Changes in the met- and leu-enkephalin levels in the rat brain during burn shock].
abstract: The dynamics of met-and leu-enkephalin content in the brain cortex and hypothalamus of rats with severe burn shock caused by 50% burns by boiling water were studied. A tendency towards burn-induced growth in leu-enkephalin hypothalamus level was observed, with the content of met-and leu-enkephalins in the hypothalamus significantly increasing 30 min later. Met-enkephalin content in the brain cortex also rises. 2 hours later the changes are less pronounced, with met-enkephalin hypothalamus level remaining elevated. The adaptive nature of changes, mobilization of endogenous anti-pain defensive mechanisms in severe burn shock and the role of hypothalamus structures in this process are suggested.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002056:Burns / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000096:biosynthesis*; D004744:Enkephalin, Methionine / Q000096:biosynthesis*; D007031:Hypothalamus / Q000378:metabolism; D051381:Rats; D012774:Shock, Traumatic / Q000378:metabolism*; D013997:Time Factors
chemical_list: D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine
vernacular_title: Izmeneniia soderzhaniia met- i leĭ-énkefalinov v strukturakh mozga krys pri ozhogovom shoke.