Sympathectomy inhibits growth of a murine plasmacytoma tumor.
The effects of 6-hydroxydopamine (6-OHDA), N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) and anti-nerve growth factor (anti-NGF) on the development and growth of a tumor of non-neuronal origin were studied in mice. Murine LPC-1 plasmacytoma cells were grown either subcutaneously (s.c.) as solid tumors in the hindleg or intraperitoneally (i.p.) in ascitic form. Growth of s.c. tumors was monitored by caliper measurements of the hindleg at the site of tumor cell inoculation; growth of ascitic tumors was followed by electrophoretic determination in plasma of the tumor associated protein IgG2a kappa, M component. Adult mice were treated with 6-OHDA or DSP-4 six hours prior to tumor cell implantation; newborn mice were treated with anti-NGF and tumor cells were given 9 weeks later. Both chemical- and immunosympathectomy significantly altered the growth pattern of solid and ascitic tumors (P less than 0.0001). The effect of sympathectomy on the growth of solid tumors was most pronounced during the early phase of tumor growth. The data document that the effect of each drug treatment on tumor growth was not due to direct cytotoxic actions of the agents employed on tumor cells but the result of impairment of sympathetic functions. The findings of this study suggest a role of the sympathetic nervous system in tumor growth.
D000818:Animals; D000831:Animals, Newborn; D001596:Benzylamines / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D007106:Immune Sera / Q000008:administration & dosage; D051379:Mice; D008807:Mice, Inbred BALB C; D009414:Nerve Growth Factors / Q000276:immunology; D016627:Oxidopamine; D010954:Plasmacytoma / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D011930:Reaction Time; D013563:Sympathectomy, Chemical / Q000379:methods
D001596:Benzylamines; D006892:Hydroxydopamines; D007106:Immune Sera; D009414:Nerve Growth Factors; D016627:Oxidopamine; D004299:Dopamine beta-Hydroxylase; C012102:DSP 4