Induction and suppression of seizures by cysteamine in hippocampal kindled rats.
Cysteamine has a biphasic effect in kindled rats. At a dose of 200 mg/kg (i.p.), hippocampal kindled rats all have myoclonic seizures during the first hour after injection, while naive rats seldom do. Four hours after cysteamine, the animals exhibited stage 5 seizures when stimulated. However, kindled seizures could not subsequently be elicited for up to 10 days in these animals.
D000818:Animals; D000927:Anticonvulsants; D003292:Convulsants; D003543:Cysteamine / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006624:Hippocampus / Q000187:drug effects*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009207:Myoclonus / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D003292:Convulsants; D003543:Cysteamine