title: Starvation increases the solubility of volatile anaesthetics in rat liver.
abstract: We evaluated the effect of starvation on anaesthetic solubility in tissues involved in lipid transport (blood) or metabolism (liver) and in a tissue not involved in either (brain). The liver/gas partition coefficients of isoflurane, enflurane, halothane and methoxyflurane in rats increased by 15-20% after 6 h of starvation and reached a maximum increase of 35-42% after 24 h of starvation. After 48 h of starvation the coefficients had returned to control values. Blood/gas and brain/gas partition coefficients were not changed or were inconsistently changed by starvation. The maximum change in blood or brain solubility was 14% (at 6 h), and 29 of 32 mean values changed less than 10%.
mesh_terms: D000777:Anesthetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004737:Enflurane / Q000378:metabolism; D005260:Female; D006221:Halothane / Q000378:metabolism; D007530:Isoflurane / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008733:Methoxyflurane / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000777:Anesthetics; D008733:Methoxyflurane; D004737:Enflurane; D007530:Isoflurane; D006221:Halothane