A macrophage factor that stimulates the proliferation of vascular endothelial cells.
Sarcoid macrophage-epithelioid cells have been shown to release a growth factor that stimulates the proliferation of vascular endothelial cells in vitro. In the presence of this factor, cultured endothelial cells can proliferate in a serum-free medium. Gel-chromatography on Sephadex G-75 revealed a single peak of activity on endothelial cells. The molecular weight was estimated at 7,000-10,000. The activity was heat-labile and trypsin-sensitive, and did not adhere to heparin-Sepharose.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002850:Chromatography, Gel; D004727:Endothelium / Q000166:cytology* / Q000187:drug effects; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D007525:Isoelectric Focusing; D008264:Macrophages / Q000032:analysis*; D008970:Molecular Weight; D012507:Sarcoidosis / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism
D006133:Growth Substances; D014357:Trypsin; D013936:Thymidine