AF64A produces long-term cognitive impairments following infusion into the lateral cerebral ventricles or the dorsal hippocampus: involvement of hippocampal cholinergic processes in learning and memory.
In summary, the data presented here suggest that depleting ACh in the HPC has long term consequences on cognitive behavior. It is suggested that HPC cholinergic processes are an important neurobiological substrate of cognitive behavior. Finally, AF64A seems a useful tool for elucidating the cholinergic mechanisms underlying the modulation of behavior.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D001596:Benzylamines / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D016627:Oxidopamine; D051381:Rats; D011916:Rats, Inbred F344
D001388:Aziridines; D001389:Azirines; D001596:Benzylamines; D006892:Hydroxydopamines; D009466:Neuromuscular Blocking Agents; D016627:Oxidopamine; C044894:ethylcholine aziridinium; D002794:Choline; C012102:DSP 4