The different response of guinea pig peritoneal macrophages to various stimulators.
To help clarify the mechanism of prostaglandin (PG) E2 and thromboxane (TX) B2 production by macrophages, the effects of three different stimulators (calcium ionophore A 23187, zymosan A and Actinomyces viscosus) on the release of arachidonic acid and the production of PGE2 and TXB2 from guinea pig macrophages were examined. In the present study, we showed that the produced levels of PGE2 and TXB2 were not dependent on the release of arachidonic acid from the phospholipids.
D000190:Actinomyces / Q000502:physiology*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001202:Ascitic Fluid; D000001:Calcimycin / Q000494:pharmacology*; D015232:Dinoprostone; D006168:Guinea Pigs; D007700:Kinetics; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D011458:Prostaglandins E / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D015054:Zymosan / Q000494:pharmacology*
D001095:Arachidonic Acids; D010743:Phospholipids; D011458:Prostaglandins E; D016718:Arachidonic Acid; D000001:Calcimycin; D013929:Thromboxane B2; D015054:Zymosan; D015232:Dinoprostone