title: Prognosis of urolithiasis and nephrocalcinosis in hypomagnesemia.
abstract: In 78 patients with hypomagnesemia in urolithiasis the clinical course of disease was established in relation to therapy and dynamics of changes of serum magnesium levels. Almost 70% of patients had multiple, bilateral or recurrent nephrolithiasis or nephrocalcinosis. 70% of patients had Ca-oxalate stones or bilateral nephrocalcinosis. In 52% of patients a long-term magnesium supplementation was necessary. Significant progress of nephrolithiasis and nephrocalcinosis was observed in 80% of patients with permanent hypomagnesemia and in 4% of patients with normalization of serum magnesium level. Three of 15 patients with hypomagnesemia and progress of disease were transplanted a kidney and two were treated by hemodialysis. All five patients with renal failure had bilateral nephrocalcinosis, in three of them familiar occurrence of nephrolithiasis and hypomagnesemia was found.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use; D002411:Cation Exchange Resins / Q000627:therapeutic use; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002951:Citrates / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007223:Infant; D007669:Kidney Calculi / Q000209:etiology* / Q000378:metabolism; D016030:Kidney Transplantation; D008275:Magnesium Deficiency / Q000150:complications* / Q000188:drug therapy; D008277:Magnesium Oxide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009397:Nephrocalcinosis / Q000188:drug therapy / Q000209:etiology; D010396:Penicillamine / Q000627:therapeutic use; D011379:Prognosis; D011736:Pyridoxine / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D002411:Cation Exchange Resins; D002951:Citrates; D006852:Hydrochlorothiazide; D008277:Magnesium Oxide; D000493:Allopurinol; D002482:Cellulose; C008881:phosphocellulose; D010396:Penicillamine; D011736:Pyridoxine