title: In vitro pulsatile flow velocity and shear stress measurements in the vicinity of mechanical mitral heart valve prostheses.
abstract: A three beam laser Doppler anemometer system was used to study the flow fields created by various types of mitral heart valve prostheses under physiological pulsatile flow conditions. The prosthetic valves studied were: Beall caged disc valve, Bjork-Shiley tilting disc valve, Medtronic-Hall tilting disc valve and St. Jude bileaflet valve. The results indicate that all four prosthetic valve designs studied create very disturbed flow fields with elevated turbulent shear stresses and regions of flow separation and/or stagnation. The observed elevated turbulent shear stresses could cause sublethal and/or lethal damage to red cells and platelets. The regions of flow separation and/or stagnation, could lead to thrombus formation and/or tissue overgrowth on the valve structure, as observed on clinically recovered prosthetic valves.
mesh_terms: D001783:Blood Flow Velocity; D006350:Heart Valve Prosthesis; D006801:Humans; D008943:Mitral Valve / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D012212:Rheology