title: Neurology and the lupus anticoagulant.
abstract: The lupus anticoagulant, an immunoglobulin of the IgG or IgM class, is one of a group of antiphospholipid antibodies. Although an anticoagulant in vitro, its action in vivo is that of a procoagulant. This procoagulant activity may involve many organ systems including the nervous system. Thus far cerebral thrombosis, spinal thrombosis, chorea and Guillain-Barré syndrome have been described in association with the lupus anticoagulant. Although the lupus anticoagulant is an uncommon cause of neurological disease, it must be considered, especially in a setting of a prolongation of the common pathway of coagulation, thrombosis and other autoimmune phenomena.
mesh_terms: D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D013921:Thrombocytopenia / Q000276:immunology; D013927:Thrombosis / Q000276:immunology
chemical_list: D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor