title: [Evaluation of regimens for the simultaneous and sequential administration of cytostatics in the combined chemotherapy of disseminated forms of breast cancer].
abstract: Fifty-eight patients with disseminated breast cancer were randomly divided into 2 study groups. All patients received 4-week courses of combination chemotherapy with vinblastine, thiotepa and 5-fluorouracil. In study group I, the drugs were injected simultaneously once a week, while, in study group II, the treatment schedule was as follows: vinblastine--on days 1 and 2, thiotepa--day 3 and 5-fluorouracil--on day 5, weekly. Leucopenia development was significantly more frequent in study group 2.
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011897:Random Allocation; D013852:Thiotepa / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014747:Vinblastine; D013852:Thiotepa; D005472:Fluorouracil
vernacular_title: Otsenka rezhimov odnovremennogo i posledovatel'nogo vvedeniia tsitostatikov pri kombinirovannoĭ khimioterapii rasprostranennykh form raka molochnoĭ zhelezy.