Evoked potentials in multiple sclerosis before and after high-dose methylprednisolone infusion.
We studied 8 patients with definite multiple sclerosis (3 with acute relapse, 5 with progression), and 2 patients with acute optic neuritis, who were treated with methylprednisolone infusions, 1 g daily for 3 days. Visual, brain stem-auditory and somatosensory-evoked potentials were used to test the effect of therapy. There were no manifest changes of the evoked potentials parameters parallel to the clinical effect of high-dose therapy.
D000328:Adult; D005071:Evoked Potentials / Q000187:drug effects*; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D009902:Optic Neuritis / Q000188:drug therapy / Q000503:physiopathology; D011446:Prospective Studies; D013979:Tibial Nerve / Q000503:physiopathology
D008775:Methylprednisolone