title: Good diabetic control early in pregnancy and favorable fetal outcome.
abstract: This study of 74 diabetic pregnant women shows that tight maternal blood glucose control before the 32nd week of gestation significantly reduces the incidence of fetal macrosomia (11%) when compared with that of patients with fair to poor control before the 32nd week of gestation (44%, P less than .05) or with those whose good diabetic control was not achieved until after the 32nd week of gestation (34%, P less than .05). The macrosomic infant produced by a diabetic mother is associated frequently with an elevated amniotic fluid C-peptide level, which shows the evidence of intrauterine fetal hyperinsulinism. The use of tight diabetic control early in pregnancy to reduce the risk of fetal macrosomia and/or neonatal complications is of clinical importance in the management of diabetes in pregnancy.
mesh_terms: D000653:Amniotic Fluid / Q000378:metabolism; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007567:Jaundice, Neonatal / Q000517:prevention & control; D008137:Longitudinal Studies; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D002096:C-Peptide