Influence of circulating maternal antibody on the transfer of dietary antigen to neonatal mice via milk.
125I-BSA injected intravenously into lactating mice persisted in the circulation for 4 h, entered the mammary gland, and was transferred to the neonate via the milk. When injected with anti-BSA antibodies, it was rapidly cleared from the circulation. Although animals receiving anti-BSA antibodies transferred more radioactivity to the neonate via the milk, the radioactivity was not TCA-precipitable or bound to staphylococcal protein A, nor was it immunoreactive. These findings suggest that circulating maternal antibody can limit the transfer of specific protein antigen from mother to newborn.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000906:Antibodies / Q000276:immunology*; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000276:immunology*; D005260:Female; D007774:Lactation; D008099:Liver / Q000276:immunology; D008321:Mammary Glands, Animal / Q000276:immunology; D051379:Mice; D008892:Milk / Q000276:immunology*; D011247:Pregnancy; D012710:Serum Albumin, Bovine / Q000276:immunology / Q000378:metabolism*; D012711:Serum Albumin, Radio-Iodinated / Q000276:immunology / Q000378:metabolism; D013270:Stomach / Q000276:immunology; D014018:Tissue Distribution
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000941:Antigens; D012711:Serum Albumin, Radio-Iodinated; D012710:Serum Albumin, Bovine