Biochemical heterogeneity of splenic purine nucleoside phosphorylase (NP-1a) from five strains of wild mice.
Inbred and wild mice having the same purine nucleoside phosphorylase-1 electromorph exhibit differences in specific activity, Michaelis constants and thermal stability. The Np-1a allele of C57BL/6J represents a high-activity variant. The Np-1 locus appears to be under regulatory control.
D000818:Animals; D004355:Drug Stability; D004592:Electrophoresis, Starch Gel; D006358:Hot Temperature; D007526:Isoelectric Point; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010430:Pentosyltransferases / Q000378:metabolism*; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology*
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase