title: Efficacy of long-acting oxytetracycline alone or combined with streptomycin in the treatment of bovine brucellosis.
abstract: Twenty-nine Brucella abortus culture-positive cows were treated with a long-acting oxytetracycline (20 mg/kg of body weight, IM) alone or combined with streptomycin (25 mg/kg, IM or IV) or were re-treated with the same product. There appeared to be a synergism by the 2 drugs. Of 21 courses of treatment with the combined antibiotics, 14 (67%) were considered successful. Only 3 of 14 (21%) were successful using oxytetracycline alone. The period from onset of therapy to cessation of shedding in udder secretions was variable. Four cows that ceased shedding were culture-positive in tissues taken at slaughter. The titers on tube agglutination and complement-fixation tests were of limited value in short-term evaluations of therapeutic regimens.
mesh_terms: D000372:Agglutination Tests / Q000662:veterinary; D000818:Animals; D002003:Brucella abortus / Q000187:drug effects; D002007:Brucellosis, Bovine / Q000188:drug therapy*; D002417:Cattle; D003168:Complement Fixation Tests / Q000662:veterinary; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D010118:Oxytetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D013307:Streptomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D010118:Oxytetracycline; D013307:Streptomycin