[Antiradiation properties of adeturon and polyanion used separately and in combination].
A study was made of the radioprotective effect of polyanion, a co-polymer of maleic and methacrylic acids, administered separately and in a combination with adeturon to irradiated (8 Gy, LD100/18) H male mice. Adeturon (300 mg/kg) was injected 15 min before, and polyanion (4 mg/kg) 24 h after gamma-irradiation. The effect of the preparations was assessed by the survival rate and hematologic indices (for instance, weight and cellularity of the spleen, bone marrow cellularity, and the number of leukocytes) at defined intervals within 30 days. Adeturon exerted a pronounced protective effect on the haemopoietic system of lethally exposed mice. The therapeutic effect of polyanion applied in a combination with adeturon was not enhanced and did not modify the effect of the latter.
D000180:Acrylic Resins / Q000627:therapeutic use*; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D002588:Cesium Radioisotopes; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005720:Gamma Rays; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D011108:Polymers / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D000338:beta-Aminoethyl Isothiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000180:Acrylic Resins; D002588:Cesium Radioisotopes; D008298:Maleates; D011108:Polymers; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; C012704:Adeturon; C048088:maleic acid-methacrylic acid copolymer; D000255:Adenosine Triphosphate
Izuchenie protivoluchevykh svoĭstv adeturona i polianiona v usloviiakh samostoiatel'nogo i sochetannogo primeneniia.