Multiple congenital ocular defects in the Akita dog.
Microphthalmia, congenital cataracts, posterior lenticonus, and retinal dysplasia were observed in members of 3 litters of Akita puppies thought to be related to a common male ancestor. The electroretinograms of 3 clinically affected puppies were normal. Histological examination of 6 microphthalmic animals revealed nuclear and cortical cataract with multiple retinal folds and rosettes predominantly overlying the tapetum lucidum. Posterior lenticonus was observed histologically in 3 of the 6 puppies.
D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005124:Eye Abnormalities; D005260:Female; D007908:Lens, Crystalline / Q000002:abnormalities; D008297:Male; D008850:Microphthalmos / Q000235:genetics / Q000662:veterinary; D012160:Retina / Q000002:abnormalities / Q000473:pathology