title: Effect of intravenous aminophylline upon the incremental exercise performance of healthy men.
abstract: Aminophylline increases the contractile force of fatiguing muscles. The effects of aminophylline upon maximal exercise performance are not defined. 6 healthy men performed incremental bicycle ergometry before and after receiving intravenous aminophylline (6 mg/kg). Maximal oxygen uptake, maximum work rate, and maximum minute ventilation were unchanged following aminophylline. Heart rate measured at rest and at 50-watt increments of work rate was significantly increased following aminophylline (p less than 0.03). The heart rate response to incremental exercise (delta HR/delta VO2) was unchanged by aminophylline. We conclude that aminophylline does not increase maximal exercise performance of healthy men.
mesh_terms: D000328:Adult; D000332:Aerobiosis / Q000187:drug effects; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects*; D012129:Respiratory Function Tests
chemical_list: D002245:Carbon Dioxide; D000628:Aminophylline