An anti-i biphasic hemolysin in chronic paroxysmal cold hemoglobinuria.
Paroxysmal cold hemoglobinuria (PCH) was diagnosed in an elderly patient with a history of chronic lymphocytic leukemia. In this case, the Donath-Landsteiner antibody demonstrated anti-i specificity rather than the more commonly reported anti-P specificity. This unusual case of a biphasic hemolysin with anti-i specificity emphasizes the importance of performing a Donath-Landsteiner test when presented with serological or clinical findings that are suggestive of PCH.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood; D000918:Antibody Specificity; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D002908:Chronic Disease; D003298:Coombs Test; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood*; D006460:Hemolysin Proteins / Q000032:analysis*; D006461:Hemolysis; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male
D001789:Blood Group Antigens; D006460:Hemolysin Proteins; D007048:I Blood-Group System; D007074:Immunoglobulin G