Capsaicin activates neurogenic non-adrenergic non-cholinergic relaxations of the isolated rat duodenum.
Capsaicin induces a transient relaxation of the isolated rat duodenum in the presence of atropine plus guanethidine. The relaxant effect of capsaicin was not observed in vitro in the duodenum of capsaicin-pretreated animals. Capsaicin-induced relaxation was antagonized by tetrodotoxin or cold storage (24 h at 4 degrees C). It is concluded that capsaicin produces a neurogenic relaxation of the rat duodenum by activating an intramural non-adrenergic non-cholinergic mechanism which inhibits intestinal motility.
D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects / Q000294:innervation; D004558:Electric Stimulation; D006145:Guanethidine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology
D006584:Hexamethonium Compounds; D013779:Tetrodotoxin; D004246:Dimethylphenylpiperazinium Iodide; D002211:Capsaicin; D009638:Norepinephrine; D006145:Guanethidine