title: Heterogeneity of brain blood flow and permeability during acute hypertension.
abstract: The purpose of this study was to examine regional autoregulation of blood flow in the brain during acute hypertension. In anesthetized cats severe hypertension increased blood flow more in cerebrum (159%) and cerebellum (106%) than brain stem (58%). In contrast to the heterogeneous autoregulatory response, hypocapnia produced uniform vasoconstriction in the brain. We also compared vasodilatation during severe hypertension with vasodilatation during hypercapnia. During hypercapnia, blood flow increased as much in brain stem, as in cerebrum and cerebellum. Thus regional differences in autoregulation appear to be specific for autoregulatory stimulus and are not secondary to nonspecific differences in vasoconstrictor or vasodilator capacity. To determine whether the blood-brain barrier is more susceptible to hypertensive disruption in regions with less effective autoregulation, permeability of the barrier was quantitated with 125I-albumin. Severe hypertension produced disruption of the barrier in cerebrum but not in brain stem. Thus there are parallel differences in effectiveness of autoregulation and susceptibility to disruption of the blood-brain barrier in different regions of the brain.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000473:pathology; D002245:Carbon Dioxide / Q000097:blood; D002415:Cats; D002560:Cerebrovascular Circulation; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D009928:Organ Specificity; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010539:Permeability; D011868:Radioisotopes; D012016:Reference Values; D012039:Regional Blood Flow
chemical_list: D011868:Radioisotopes; D002245:Carbon Dioxide; D010100:Oxygen