title: Selective phosphorylation of human DNA methyltransferase by protein kinase C.
abstract: Human DNA methyltransferase, the enzyme thought to be responsible for the somatic inheritance of patterns of DNA methylation, is an effective substrate for phosphorylation by protein kinase C. This provides a plausible mechanistic link between the action of tumor promoting phorbol esters, which stimulate protein kinase C, and abnormal patterns of DNA methylation often observed in transformed cells.
mesh_terms: D002118:Calcium / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D010743:Phospholipids / Q000494:pharmacology; D010766:Phosphorylation; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011493:Protein Kinase C / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D010743:Phospholipids; D004247:DNA; D004248:DNA (Cytosine-5-)-Methyltransferases; D011494:Protein Kinases; D011493:Protein Kinase C; D002118:Calcium