title: Bronchial hyperreactivity and bronchial obstruction in respiratory viral infection. An attempt to evaluate the relationship.
abstract: The aim of this study was to investigate the relation of viral respiratory infection with bronchial hyperreactivity and bronchial obstruction. A viral infection using a live attenuated influenza virus was induced successfully in 10 of 30 patients with chronic obstructive pulmonary disease (COPD) and in 3 subjects without COPD (non-COPD). No significant change in bronchial reactivity and lung function could be found in comparison with the baseline values.
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D004804:Eosinophils; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D007958:Leukocyte Count; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000503:physiopathology; D008297:Male; D012141:Respiratory Tract Infections / Q000150:complications / Q000503:physiopathology*; D014777:Virus Diseases / Q000150:complications / Q000503:physiopathology*; D014797:Vital Capacity
chemical_list: D007252:Influenza Vaccines