title: Gastric motility is a major factor in cold restraint-induced lesion formation in rats.
abstract: These studies were performed to characterize the pattern of gastric contractility associated with cold restraint-induced lesion formation. Gastric motility in the rat was examined with extraluminal transducers at three sites of the stomach. The motility was monitored in the 24-h-fasted state, the postprandial state, and during cold-water immersion restraint. Gastric acid secretion was also monitored in a separate group of animals placed in cold restraint. Both feeding and cold restraint resulted in an equivalent increase in the amplitude of gastric contractions. Prolonged cold restraint, however, resulted in a distinct contractile pattern in which contractions were 56% less frequent and 300-400% longer in duration than those stimulated by feeding. All cold-restrained animals developed multiple gastric erosions. Cold restraint was not associated with increased acid secretion. A single subcutaneous injection of papaverine HCl (50 or 100 mg/kg) suppressed cold restraint-induced high-amplitude contractions and the cold restraint-induced lesion formation without altering acid secretion. These studies suggest that the stimulation of high-amplitude, prolonged duration contractions are more important than changes in gastric acid secretion in the formation of cold restraint-induced gastric lesions.
mesh_terms: D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D004435:Eating; D005215:Fasting; D005744:Gastric Acid / Q000378:metabolism; D005769:Gastrointestinal Motility; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical / Q000009:adverse effects*; D013272:Stomach Diseases / Q000209:etiology*; D013997:Time Factors
chemical_list: D010208:Papaverine