title: In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.
abstract: Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.
mesh_terms: D000658:Amoxicillin / Q000378:metabolism / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D002433:Cefaclor / Q000378:metabolism / Q000494:pharmacology; D015296:Ceftizoxime / Q000031:analogs & derivatives*; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology*; D002969:Clavulanic Acids / Q000494:pharmacology; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D002511:Cephalosporins; D002969:Clavulanic Acids; C047444:cefetamet; D002433:Cefaclor; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D015296:Ceftizoxime; D001618:beta-Lactamases; C047445:cefetamet pivoxyl