Malignant hyperthermia triggered by heating in anaesthetized pigs.
Three malignant hyperthermia susceptible (MHS) and three normal Danish landrace pigs were heated using a water-heated mattress, warm blankets and warm intravenous saline during anaesthesia with barbiturate and 50% nitrous oxide in oxygen. The MHS pigs developed typical malignant hyperthermia (MH) at a rectal temperature of 41.0 +/- 0.7 degrees C, whereas the normal pigs tolerated heating to the same temperature without any ill effects. Haemodynamic and metabolic findings during MH were similar to those previously reported for anaesthetic-induced MH in pigs. Heat intolerance may thus be one factor in the genesis of MH.
D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D001794:Blood Pressure; D001831:Body Temperature; D002245:Carbon Dioxide / Q000378:metabolism; D006358:Hot Temperature / Q000009:adverse effects*; D008305:Malignant Hyperthermia / Q000209:etiology* / Q000378:metabolism; D011188:Potassium / Q000097:blood; D013552:Swine
D002245:Carbon Dioxide; D011188:Potassium