[Inhibiting effect of dioxidine on corticosteroid secretion in an experiment].
The determination of corticosterone and aldosterone levels in the peripheral blood of rats and a cortisol level in the blood of guinea pigs by a radioimmunoassay following the administration of dioxydin (1,4-N-oxide 2 2,3-dioxymethylquinoxaline) has shown that it produces an inhibiting effect upon the secretion of corticosteroid hormones in animals with a diverse direction of their biosynthesis. There is a dose dependence of the effect detected. Substitution therapy with corticosteroids cuts short adrenal insufficiency caused by dioxydin.
D000305:Adrenal Cortex Hormones / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood; D011810:Quinoxalines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D011810:Quinoxalines; C001077:dioxidine; D000450:Aldosterone; D003345:Corticosterone; D006854:Hydrocortisone
Ingibiruiushchee vliianie dioksidina na sekretsiiu kortikosteroidov v éksperimente.