The acquisition of a kindled response in developing rats using 24-h intertrial intervals.
The purpose of this study was to evaluate a methodology which would permit serial EEG recordings and daily amygdaloid kindling stimulations in young rats (16-26 days old). The preparation was sufficient to maintain the developing rats for 26 consecutive days of stimulation and recording and to permit the acquisition of kindled seizures. Developing rats required a slightly greater number of trials to acquire the kindled response than did adult rats in previous studies using a 24-h intertrial interval.
D000367:Age Factors; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D013997:Time Factors