Tumor promoters potentiate the adrenomedullary secretion induced by acetylcholine and excess K possibly by stimulating phorbol ester receptors.
Catecholamine secretion from the perfused cat adrenal in response to 15 mM KC1 or acetylcholine was significantly increased by treatment with active tumor promoters. A good correlation was found between potentiation of the secretory response and the phorbol ester receptor binding activity, suggesting that promoters modulate the secretory mechanism via the receptors.
D000109:Acetylcholine / Q000494:pharmacology*; D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002273:Carcinogens / Q000494:pharmacology*; D002352:Carrier Proteins; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D008235:Lyngbya Toxins / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D011493:Protein Kinase C; D011955:Receptors, Drug; D011971:Receptors, Immunologic / Q000502:physiology*; D013268:Stimulation, Chemical; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors
D029742:Caenorhabditis elegans Proteins; D002273:Carcinogens; D002352:Carrier Proteins; D002395:Catecholamines; D008235:Lyngbya Toxins; D011955:Receptors, Drug; D011971:Receptors, Immunologic; C083141:phorbol ester binding protein; C027776:phorbol ester receptor; C022176:teleocidins; D011493:Protein Kinase C; D009543:Nifedipine; D000109:Acetylcholine; D013755:Tetradecanoylphorbol Acetate; D011188:Potassium