title: Phase II trials of hexamethylmelamine, dianhydrogalactitol, razoxane, and beta-2'-deoxythioguanosine as single agents against advanced measurable tumors of the pancreas. Gastrointestinal Tumor Study Group.
abstract: Phase II trials of several single agents demonstrated only minimal objective response rates in patients with pancreatic carcinoma and measurable tumors: hexamethylmelamine (7%; four responses among 55 patients); dianhydrogalactitol (2.5%; one response among 40 patients); razoxane (7%; two responses among 29 patients); and beta-2'-deoxythioguanosine (6%; two responses among 32 patients). Among patients with a good performance status (0-2) and no prior chemotherapy, response rates were 8% for hexamethylmelamine (two responses among 26 patients); 8% for dianhydrogalactitol (one response among 13 patients); 8% for razoxane (one response among 12 patients); and 10% for beta-2'-deoxythioguanosine (two responses among 20 patients). None of these agents given by the methods of this study offers substantive benefit to the patient with advanced pancreatic cancer.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D006585:Altretamine / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003961:Dianhydrogalactitol / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D010190:Pancreatic Neoplasms / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use*; D011929:Razoxane / Q000627:therapeutic use*; D013402:Sugar Alcohols / Q000627:therapeutic use*; D013872:Thionucleosides / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; D013402:Sugar Alcohols; D013872:Thionucleosides; D014227:Triazines; D003961:Dianhydrogalactitol; D011929:Razoxane; C010438:beta-2'-deoxythioguanosine; D003849:Deoxyguanosine; D006585:Altretamine