Iontophoresis of fluorescein into the posterior segment of the rabbit eye.
Iontophoresis of appreciable quantities of fluorescein into the vitreous body of the rabbit results from the use of a high electrical current density over a limited area of the globe. This is achieved by passing current through the fluorescein when it is held against the region of the ora serrata in a tube less than 1 mm in diameter. The retina is destroyed over a corresponding area when the current enters the eye. An electrode is described which is held to the eye by suction and could be practical for clinical applications.
D000818:Animals; D004566:Electrodes; D005131:Eye Injuries / Q000209:etiology / Q000473:pathology; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000008:administration & dosage* / Q000378:metabolism; D007478:Iontophoresis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D011817:Rabbits; D014822:Vitreous Body
D005452:Fluoresceins; D019793:Fluorescein