Management of haemophilia A with antibodies--the effect of combined treatment with factor VIII, hydrocortisone and cyclophosphamide.
Immune tolerance has by several methods been induced in haemophiliacs with antibodies. A conversion of "high responders" into "low responders" was previously reported after repeated moderate factor IX doses over periods of 7-10 days in combination with cyclophosphamide and steroids in two patients with haemophilia B and inhibitors. This paper reports similar results in a haemophilia A patient by giving factor VIII, cyclophosphamide, and steroids during relatively short periods of time (7-8 days). The anamnestic response markedly decreased already following the first treatment and never exceeded a level of 1 u/ml (approximately 3 BU/ml) even when boosted with ordinary factor VIII doses for only 3 days. It is concluded that the markedly decreased secondary antibody response is most probably the result of factor VIII given at short intervals (twice a day) for periods of up to about one week when given in combination with cyclophosphamide and steroids. The same effect may be achieved by other methods. The treatment schedule suggested in the present paper is, however, simple and avoids long periods of high antibody levels. Furthermore, the total factor VIII dose used is lower than suggested in most other treatment schedules, which makes the treatment substantially less expensive.
D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000008:administration & dosage* / Q000276:immunology; D006467:Hemophilia A / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged
D003520:Cyclophosphamide; D005169:Factor VIII; D006854:Hydrocortisone