Brain histamine turnover enhanced by footshock.
When footshock was given to mice at 15-s intervals for 30-120 min, there was a significant increase in the brain level of tele-methyl-histamine (t-MH), a predominant metabolite of brain histamine (HA). This footshock-induced elevation of the t-MH level also occurred in mice pretreated with pargyline but not in mice pretreated with metoprine. The footshock facilitated the HA depletion induced by a-fluoromethylhistidine. These results suggest that footshock increases the brain HA turnover.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004597:Electroshock; D005528:Foot / Q000502:physiology*; D006632:Histamine / Q000378:metabolism*; D008297:Male; D008761:Methylhistamines / Q000378:metabolism; D008762:Methylhistidines / Q000494:pharmacology; D051379:Mice; D010293:Pargyline / Q000494:pharmacology; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology
D008761:Methylhistamines; D008762:Methylhistidines; C006308:metoprine; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D010293:Pargyline; C020404:tele-methylhistamine; D011739:Pyrimethamine