[3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years.
Chronic treatment of rats with manganese (1 mg MnCl2 X 4H2O per ml of drinking water) from conception till adulthood only slightly decreased [3H]spiperone binding in striatal membranes whereas [3H]quinuclidinyl benzilate binding was not affected. The age-related decreases in dopaminergic and muscarinic cholinergic receptor binding in striatal membranes were not affected by the life-span manganese treatment.
D000367:Age Factors; D000818:Animals; D002712:Chlorides; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D017895:Manganese Compounds; D020149:Manganese Poisoning; D008566:Membranes / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013997:Time Factors
D002712:Chlorides; D017895:Manganese Compounds; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D013134:Spiperone; D011813:Quinuclidinyl Benzilate; C025340:manganese chloride