title: The induction of reciprocal translocations in rhesus monkey stem-cell spermatogonia: effects of low doses and low dose rates.
abstract: The induction of reciprocal translocation in rhesus monkey spermatogonial stem cells was studied following exposure to low doses of acute X rays (0.25 Gy, 300 mGy/min) or to low-dose-rate X rays (1 Gy, 2 mGy/min) and gamma rays (1 Gy, 0.2 mGy/min). The results obtained at 0.25 Gy of X rays fitted exactly the linear extrapolation down from the 0.5 and 1.0 Gy points obtained earlier. Extension of X-ray exposure reduced the yield of translocations similar to that in the mouse by about 50%. The reduction to 40% of translocation rate after chronic gamma exposure was clearly less than the value of about 80% reported for the mouse over the same range of dose rates. Differential cell killing with ensuing differential elimination of aberration-carrying cells is the most likely explanation for the differences between mouse and monkey.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008253:Macaca mulatta; D008297:Male; D011831:Radiation Genetics; D013093:Spermatogonia / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D013234:Stem Cells / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000528:radiation effects*