[Current concepts of the functional characteristics of the muscarinic cholinoceptor].
Methodical approaches to the investigation of M-cholinoreceptors of the CNS and peripheral organs are considered. The materials on heterogeneity of M-cholinoreceptors population and the ways of interconversion of their heterogeneous molecular forms are discussed. Special attention is given to the contribution of G-proteins to the functioning of M-cholinoreceptors and to the role of guanylic nucleotides in changes of their affinity to cholinergic ligands. Materials are presented on the participation of guanyl nucleotides--G-protein system in the realization of the functional interrelations of cholino- and adrenoreactive systems.
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006150:Guanine Nucleotides / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006165:Guanylyl Imidodiphosphate / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D009206:Myocardium / Q000378:metabolism; D010276:Parasympatholytics / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011976:Receptors, Muscarinic / Q000145:classification / Q000187:drug effects / Q000502:physiology*
D006150:Guanine Nucleotides; D008024:Ligands; D010276:Parasympatholytics; D011976:Receptors, Muscarinic; D006165:Guanylyl Imidodiphosphate; D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins
Sovremennye predstavleniia o nekotorykh osobennostiakh funktsionirovaniia muskarinovogo kholinoretseptora.