Local controlled-release of diphosphonates from ethylenevinylacetate matrices prevents bioprosthetic heart valve calcification.
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D002114:Calcinosis / Q000517:prevention & control*; D002118:Calcium / Q000378:metabolism; D003692:Delayed-Action Preparations; D012968:Etidronic Acid / Q000008:administration & dosage*; D006350:Heart Valve Prosthesis; D008297:Male; D011145:Polyvinyls; D013552:Swine
D003692:Delayed-Action Preparations; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D012968:Etidronic Acid; D002118:Calcium