title: Low-iodine diet for the production of severe I deficiency in marmosets (Callithrix jacchus jacchus).
abstract: A low-iodine diet consisting of maize, peas (Pisum sativum), torula yeast, meat meal, maize oil and added vitamins, minerals and amino acids was given to eight pairs of adult, common cotton-eared marmosets (Callithrix jacchus jacchus). Eight control pairs were given the same diet to which potassium iodate was added. Both groups also received low-I apple and deionized water. The diet provided adequate nutrition, as confirmed by the maintenance of body-weight and good health. In the I-deficient marmosets the concentration of plasma thyroxine was decreased from 140.1 nmol/l to 22.4 nmol/l and thyroid-stimulating hormone increased significantly from 1.8 ng/ml to 9.0 ng/ml compared with control marmosets, thereby indicating severe I deficiency. Compared with newborn offspring from control marmosets, the thyroid glands from the I-deficient offspring showed an increase in weight, a decrease in I content and, on histological examination, hyperplasia, hypertrophy and a total absence of colloid material in the follicles.
mesh_terms: D000818:Animals; D001835:Body Weight; D002143:Callitrichinae; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D007455:Iodine / Q000172:deficiency*; D008297:Male; D013961:Thyroid Gland / Q000473:pathology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
chemical_list: D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine