Adverse effects of pregnancy on multifocal eosinophilic granuloma.
An unusual case of a patient diagnosed as having the histiocytic proliferative disorder characterized by the lesion eosinophilic granuloma (histiocytosis X) is presented. Fifteen-year follow-up revealed a progression from a solitary eosinophilic granuloma of the bone to multifocal involvement of many body structures including the vulva, vagina, and cervix. This progression occurred after nine asymptomatic years and was temporally related to the patient's first pregnancy. After successful treatment and remission, rapid appearance and growth of observable genital lesions were noted during a second pregnancy. Pregnancy termination in the first trimester was advised due to signs of dissemination and local symptoms.
D000032:Abortion, Therapeutic; D000328:Adult; D001847:Bone Diseases / Q000188:drug therapy / Q000209:etiology; D004803:Eosinophilic Granuloma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D005260:Female; D005882:Gingival Diseases / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D006801:Humans; D009916:Orbital Diseases / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D002577:Uterine Cervical Diseases / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D014623:Vaginal Diseases / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy; D014845:Vulvar Diseases / Q000188:drug therapy / Q000209:etiology / Q000532:radiotherapy