Enhanced responsiveness of the coronary blood vessel of the dog heart-lung preparation to PGI2 after chronic chemical sympathectomy.
Chronic chemical denervation of the sympathetic nervous system with 6-OH dopamine resulted in an augmentation of the coronary blood flow (CBF) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto PGF1 alpha in the circulating blood. In denervated HLP, 6-keto PGF1 alpha was lower and the vasodilator response to PGI2 larger at the start of the experiments. It was concluded that exaggerated increase in CBF was due to a potentiation of the vasodilator response to PGI2.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects*; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D016627:Oxidopamine; D013563:Sympathectomy, Chemical; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
D006892:Hydroxydopamines; D015121:6-Ketoprostaglandin F1 alpha; D016627:Oxidopamine; D011464:Epoprostenol