Uterotropic hormones produced by ovaries of Sl/Slt mutant mice before spontaneous development of tubular adenomas.
Tubular adenomas developed spontaneously in ovaries of (WB X C57BL/6)F1-Sl/Slt and -W/Wv mice after 150 days of age. The uteri of the W/Wv mice were hypoplastic before development of tubular adenomas, but the uteri of the Sl/Slt mice were not. Since oophorectomy significantly reduced the uterus weight in the Sl/Slt mice, we investigated the androgen- and estrogen-producing activity of Sl/Slt and W/Wv mice before development of tubular adenomas. Fragments of ovaries were cultured for 48 hr in serum-free medium containing either progesterone or 4-androstene-3,17-dione (androstenedione). The amount of androgens produced from progesterone by ovaries of Sl/Slt mice in the presence of human chorionic gonadotropin was comparable to that of W/Wv mice. In contrast, the amount of estrogens produced from androstenedione by ovaries of Sl/Slt mice in the presence of follicle stimulating hormone was much greater than that of W/Wv mice. Moreover, the amount of estrogens produced was much greater than the amount of androgens in the ovaries of Sl/Slt mice. Therefore, before development of tubular adenomas, estrogens rather than androgens seem to be a major uterotropic hormone produced by ovaries of Sl/Slt mice.
D000236:Adenoma / Q000209:etiology*; D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D051379:Mice; D008817:Mice, Mutant Strains; D009929:Organ Size; D010051:Ovarian Neoplasms / Q000209:etiology*; D011374:Progesterone / Q000378:metabolism; D014599:Uterus / Q000032:analysis / Q000378:metabolism*
D000728:Androgens; D004967:Estrogens; D000735:Androstenedione; D011374:Progesterone