Absorption of intragastrically administered DDAVP in conscious dogs.
Plasma concentrations of DDAVP were measured after intragastric administration and intravenous infusion in dogs. Oral ingestion of DDAVP led to a dose dependent increase in peak plasma concentrations as well as area under the curve (AUC). Intravenous infusion of DDAVP (0.13 pmol/l min) resulted in a mean steady-state level of 20.3 pmol/l. Elimination half-lives for oral DDAVP were 77.6 and 76.1 min for low and high doses respectively. T1/2 estimated from the ascending part of the i.v. infusion curve was 50 min. A metabolic clearance rate (MCR) of 3.9 ml/kg . min was assessed from the i.v. steady-state level.
D000042:Absorption; D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006207:Half-Life; D007700:Kinetics; D013270:Stomach
D003894:Deamino Arginine Vasopressin