[2 cases of metabolic acidosis during therapy of portosystemic encephalopathy with branched-chain amino acids].
Two patients known to be suffering from liver cirrhosis were admitted to hospital in a state of coma. The apparent ineffectiveness of treatment with branched chain amino acids was found in reality to be due to the onset of metabolic acidosis. The suspension of treatment and balancing of the metabolic imbalance with an infusion of bicarbonate solutions led to lessening of the neurological symptomatology.
D000138:Acidosis / Q000139:chemically induced* / Q000188:drug therapy; D000368:Aged; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000009:adverse effects*; D001639:Bicarbonates / Q000008:administration & dosage; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D012996:Solutions
D000597:Amino Acids, Branched-Chain; D001639:Bicarbonates; D012996:Solutions
Due casi di acidosi metabolica in corso di terapia con soluzioni di aminoacidi a catena ramificata per encefalopatia porto-sistemica.