Effects of chemotherapy on mice submitted to multiple Schistosoma mansoni infections. A controlled randomized prospective study.
In an attempt to reproduce experimentally as close a possible the conditions found in endemic areas of mansonian schistosomiasis, a controlled trial in mice submitted to weakly infections with cercariae of S. mansoni was performed. One group (I) was not treated, the other (II) was treated with a single oral doses (100 mg/kg) of oxamniquine at the 13th week. After treatment infections were maintained bi-weekly. Mortality was significantly higher in group I (p less than 0.0001). A comparative morphological and immunoenzymatic study of the liver in the two groups was also carried out, showing a tendency to smaller granulomas and to more efficient antigen restriction in the treated group.
D000284:Administration, Oral; D000818:Animals; D000947:Antigens, Helminth / Q000032:analysis; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000473:pathology; D007124:Immunoenzyme Techniques; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D051379:Mice; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D011897:Random Allocation; D012550:Schistosoma mansoni / Q000276:immunology; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology / Q000473:pathology
D000947:Antigens, Helminth; D009600:Nitroquinolines; D010073:Oxamniquine