A unique element resembling a processed pseudogene.
We describe a unique DNA element with structural features of a processed pseudogene but with important differences. It is located within an 8.4-kilobase pair region of chicken DNA containing five histone genes, but it is not related to these genes. The presence of terminal repeats, an open reading frame (and stop codon), polyadenylation/processing signal, and a poly(A) rich region about 20 bases 3' to this, together with a lack of 5' promoter motifs all suggest a processed pseudogene. However, no parent gene can be detected in the genome by Southern blotting experiments and, in addition, codon boundary values and mid-base correlations are not consistent with a protein coding region of a eukaryotic gene. The element was detected in DNA from different chickens and in peafowl, but not in quail, pheasant, or turkey.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001717:Birds; D002645:Chickens; D005796:Genes; D005914:Globins / Q000235:genetics; D006657:Histones / Q000235:genetics; D006801:Humans; D051379:Mice; D011817:Rabbits; D012091:Repetitive Sequences, Nucleic Acid
D006657:Histones; D005914:Globins