Effect of acidosis and hypoxia on intestinal blood flow of sheep fetus.
In sheep fetuses 110-130 days of age acidosis (blood pH 6.95; produced by infusion with 1.1 M lactic acid) significantly lowered blood flow (ml/min/100g) to the full thickness wall of the jejunum from 135 +/- 11 to 93 +/- 14 and in the full thickness wall of the ileum from 122 +/- 13 to 95 +/- 11. The decrease was mainly due to the decline in blood flow to mucosa of the segment, where flow decreased from 182 +/- 20 to 83 +/- 14 in the jejunum and from 130 +/- 10 to 107 +/- 9 in the ileum. Fetal hypoxemia (PaO2 of 14.9 mm Hg; induced by allowing ewes to breath 11.1% O2 and 88.9% nitrogen) reduced blood flow only to the jejunal mucosa from 142 +/- 14 to 99 +/- 16. The reduction in blood flow to the full thickness wall of the jejunum and the ileum did not change significantly from the control period, when PaO2 was 25 mm Hg.
D000138:Acidosis / Q000196:embryology*; D000818:Animals; D005260:Female; D005333:Fetus / Q000502:physiology*; D000860:Hypoxia / Q000196:embryology*; D007082:Ileum / Q000098:blood supply / Q000196:embryology; D007413:Intestinal Mucosa / Q000098:blood supply / Q000196:embryology; D007422:Intestines / Q000098:blood supply / Q000196:embryology*; D007583:Jejunum / Q000098:blood supply / Q000196:embryology; D011247:Pregnancy; D012039:Regional Blood Flow; D012756:Sheep / Q000196:embryology