title: Fine tuning of ribosomal accuracy.
abstract: If the rate constant for peptide bond formation were high just after an amino acid incorporation and occasionally switched to a lower value afterwards, then the ribosome could compensate for tRNA imbalance specifically at hungry codons. A rigorous analysis of the scheme proves its effectiveness. For instance, a 10-fold reduction in cognate tRNA concentration may increase the error rate by only a factor of two.
mesh_terms: D003062:Codon / Q000378:metabolism; D007700:Kinetics; D008957:Models, Genetic; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000378:metabolism; D012270:Ribosomes / Q000502:physiology*
chemical_list: D003062:Codon; D012343:RNA, Transfer