Ankylosing spondylitis and rheumatoid arthritis in a patient with Paget's disease. Differential effects of indomethacin, D-penicillamine, or gold sodium thiomalate in the respective arthritides.
A patient developed both ankylosing spondylitis and rheumatoid arthritis, each of which responded to D-penicillamine or gold sodium thiomalate and indomethacin, respectively. The patient was both HLA-B27 and -DR4 positive. In addition, he was found to have Paget's disease of bone, which has required no treatment.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D010001:Osteitis Deformans / Q000150:complications*; D010396:Penicillamine / Q000627:therapeutic use*; D011859:Radiography; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D006052:Gold Sodium Thiomalate; D010396:Penicillamine; D007213:Indomethacin