title: A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes.
abstract: Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic; D004247:DNA / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008540:Meiosis; D051379:Mice; D010641:Phenotype; D011995:Recombination, Genetic; D014960:X Chromosome / Q000502:physiology*; D014998:Y Chromosome / Q000502:physiology*
chemical_list: D004247:DNA