[Structure of the progesterone receptor of chick oviduct. The 110 kDa B protein which binds the hormone has affinity for DNA].
Purified "B" protein (MW approximately 110 kDa) that binds progesterone, and more than 90% of the activated receptor labelled with tritiated hormone in the oviduct cytosol of chicks pretreated with estrogen have the same chromatography behavior on DNA-cellulose. Conversely, neither the nonactivated "8S" receptor, that includes the heat-shock protein hsp90, nor the later bind to DNA. With other biochemical and immunological arguments, these results indicate that the hormone binding B unit of the progesterone receptor binds DNA as do all steroid hormone receptors.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D005260:Female; D008970:Molecular Weight; D010057:Oviducts / Q000378:metabolism*; D011485:Protein Binding; D011980:Receptors, Progesterone / Q000378:metabolism*
D011980:Receptors, Progesterone; D004247:DNA
Structure du récepteur de la progestérone de l'oviducte de poule. La protéine B de 110 kDa liant l'hormone a de l'affinité pour l'ADN.