Effects of propranolol on myocardial damage resulting from coronary artery occlusion followed by reperfusion.
To evaluate the effects of propranolol on myocardial metabolism after coronary reperfusion, serial measurements of myocardial creatine kinase (CK) and calcium (Ca) contents and CK and lactic acid (LA) concentrations in coronary sinus blood were carried out in 33 open-chest dogs. The left anterior descending coronary artery was occluded for 60 minutes and was then reopened. Twelve of the dogs were given propranolol before occlusion. Reperfusion for 30 minutes in dogs with and without propranolol pretreatment resulted in reduced myocardial CK in the ischemic region and rapidly elevated plasma CK and LA. However, when compared with the control group, the propranolol-treated group showed smaller changes in myocardial CK and plasma LA. Myocardial Ca in the ischemic region was significantly higher than that in the nonischemic region in the control group, but not in the propranolol-treated group. It was concluded that propranolol was protective against myocardial damage resulting from coronary occlusion followed by reperfusion.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood / Q000378:metabolism; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D010477:Perfusion; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000494:pharmacology*; D013997:Time Factors
D007773:Lactates; D019344:Lactic Acid; D011433:Propranolol; D003402:Creatine Kinase; D011188:Potassium; D002118:Calcium