Alternative involvement of two cytogenetically distinguishable breakpoints on chromosome 8 in Burkitt's lymphoma associated translocations.
The chromosomes of 16 Burkitt's lymphoma (BL) derived cell lines were submitted to high-resolution G-band analysis. They included seven lines with t(8;14), three with t(2;8), and four with t(8;22). The translocation breakpoint in chromosome #14 was located in 14q32.3, in chromosome #2 in 2p11.1, and in chromosome #22 in 22q12.12. In chromosome #8, the translocation breakpoint was located in two cytogenetically distinct subbands: 8q24.1 in cell lines with t(8;14) and t(2;8) and 8q24.22 in cell lines with t(8;22). In the light of recent molecular findings, these results indicate that the distance between the c-myc gene, located in 8q24, and the Ig sequences might be much larger in BL lines with t(8;22) than in those with t(2;8).
D002051:Burkitt Lymphoma / Q000235:genetics*; D002460:Cell Line; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D009857:Oncogenes; D014178:Translocation, Genetic