Effects of d,l-propranolol on open field behavior of rats.
Rats were administered with different doses of d,l-propranolol or d,l-propranolol plus amphetamine before open-field observations. Results show that d,l-propranolol decreased locomotion and rearing frequencies and increased immobility duration in rats. An antagonism between the effects of amphetamine and d,l-propranolol on general activity of rats was also observed. Results are discussed in the light of a possible interference of the drugs with the activity of either noradrenergic neurons or mid-brain reticular formation.
D000661:Amphetamine / Q000037:antagonists & inhibitors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011433:Propranolol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011433:Propranolol; D000661:Amphetamine