Development of the gamma-aminobutyric acid neurotransmitter system in the rat cerebral cortex during repeated administration of the GABA-transaminase inhibitor ethanolamine O-sulphate.
Ethanolamine O-sulphate (400 mg/kg, i.p.) was administered to rat pups at 9 days of age and on alternate days up to 17 days of age. At 18 days of age, gamma-aminobutyric acid (GABA) concentration was increased (three- to fourfold), glutamic acid decarboxylase (GAD) activity reduced to 55% of control, and the number of GABAA and GABAB binding sites increased in the cerebral cortex. This is the same pattern of change as seen previously with oral administration of ethanolamine O-sulphate to the adult rat but the changes occur more rapidly in the developing rat. A lower dose of ethanolamine O-sulphate (100 mg/kg, i.p.), administered according to the same schedule, caused a twofold increase in cortical GABA at 18 days of age whereas GAD activity and GABAA binding were not significantly altered.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites; D001835:Body Weight / Q000187:drug effects; D002540:Cerebral Cortex / Q000032:analysis / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000494:pharmacology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism / Q000502:physiology*
D004983:Ethanolamines; D005680:gamma-Aminobutyric Acid; C020619:ethanolamine O-sulfate; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase