Biological tolerance to polydioxanone absorbable clips: a comparison with metallic ligating clips.
An experiment was conducted in 96 rats to determine the tissue tolerance to a hemostatic and absorbable clip made of polydioxanone, as compared to standard metallic clips. Clinical tolerance was similar and no bleeding or death occurred because of the material. Pathological studies showed a mild histiocytic reaction with absorbable clips and a stronger inflammatory reaction with metallic clips. This experiment indicates that absorbable clips are efficient and well tolerated and we strongly recommend the use of this material.
D000042:Absorption; D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D006487:Hemostasis; D007249:Inflammation / Q000209:etiology / Q000473:pathology; D008297:Male; D008670:Metals / Q000633:toxicity; D016687:Polydioxanone; D011091:Polyesters / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013537:Sutures
D001672:Biocompatible Materials; D008670:Metals; D011091:Polyesters; D016687:Polydioxanone