Lysolecithin-induced Ca2+ uptake by pigeon red cells.
Lysolecithin (LPC) induced a rapid but transitory increase in 45Ca2+ influx, and an abrupt 45Ca2+ net uptake by pigeon red cells. The effect on uptake was seen with doses of added lysolecithin calculated to be 2.1-8.4% of the cytoplasmic membrane phospholipid, well within the reported physiological range of 1-9%. Lysolecithin effects were not due to prelytic membrane changes nor action as a platelet activating factor agonist. Changes in the amino acids in the medium mimicking human homocysteinuria, an atherosclerosis risk factor, increased the lysolecithin effect. The findings are consistent with a role for lysolecithin in atherosclerosis.
D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism; D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002132:Calcium Radioisotopes; D010856:Columbidae / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006710:Homocysteine / Q000378:metabolism; D007700:Kinetics; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
D000596:Amino Acids; D002132:Calcium Radioisotopes; D008244:Lysophosphatidylcholines; D006710:Homocysteine; D012964:Sodium; D002118:Calcium