Effect of adrenalectomy on gamma-aminobutyric acid concentrations in the central nervous system.
Pyridoxal-5'-phosphate (PLP) plays a crucial role in regulating the steady-state levels of gamma-aminobutyric acid (GABA) in CNS. Adrenalectomy resulted in decreased conversion of dietary vitamin B6 to PLP. As a consequence of this, GABA levels in cerebral cortex decrease, since synthesis of GABA is determined by glutamate decarboxylase, a PLP-dependent enzyme. Feeding diet supplemented with vitamin B6 elevated the GABA levels in adrenalectomized animals, because of increased availability of the coenzyme for apodecarboxylase. The data suggest a role for corticosteroids in maintaining GABA levels, through their effects on PLP formation.
D000315:Adrenalectomy; D000818:Animals; D002540:Cerebral Cortex / Q000032:analysis*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D008099:Liver / Q000032:analysis; D008297:Male; D011732:Pyridoxal Phosphate / Q000032:analysis / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D005973:Glutamine; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D005968:Glutamate Decarboxylase