[Effect of amidopyrine on the rate of cytochrome P-450 isoform breakdown].
The effect of liver monooxygenase system substrates upon the rate of cytochrome P-450 isoform degradation was investigated by measuring the half-life of liver microsomal proteins in C57BL/6 mice injected with phenobarbital and then 24 hours later with aminopyrine every 6 hours. The rate of phenobarbital-induced degradation of cytochrome P-450 isoform (mol weight 56000 daltons) was shown to be increased two-fold.
D000632:Aminopyrine / Q000494:pharmacology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006207:Half-Life; D007536:Isomerism; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010105:Oxygenases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011506:Proteins / Q000378:metabolism; D013379:Substrate Specificity / Q000187:drug effects; D013997:Time Factors
D011506:Proteins; D000632:Aminopyrine; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D010634:Phenobarbital
Vliianie amidopirina na skorost' raspada izoform tsitokhroma P-450.