Reduced aggregation capacity of washed platelets and dysfibrinogenaemia in rats given butylated hydroxytoluene.
Calcium-dependent aggregation of washed platelets and the fibrin monomer polymerization (FMP) ratio were determined in rats fed 1.20% butylated hydroxytoluene (BHT) for 7 days. Thrombin-induced aggregation was significantly reduced in rats given BHT, but calcium ionophore A23187-induced aggregation was not. The FMP ratio was significantly increased by BHT administration. These results provide additional evidence of defective platelet function and coagulation-factor abnormality (dysfibrinogenaemia) in rats fed BHT.
D000818:Animals; D001704:Biopolymers; D001780:Blood Coagulation Tests; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D005340:Fibrinogen / Q000378:metabolism*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000494:pharmacology
D001704:Biopolymers; D002084:Butylated Hydroxytoluene; D000001:Calcimycin; D005340:Fibrinogen; D013917:Thrombin