[Phorbol diester induces phenotypic and functional changes in human T-lymphocyte clones].
Tumor promoting phorbol myristate acetate (PMA) induce to enhance the expression of IL2 Receptor and to decrease the antigen receptor expression on the cell surface. The same phenotypic changes are also observed when the T cell clones are stimulated by the specific ligand. In contrast to the IL2 Receptor induced by the specific antigen, the ones induced by PMA are less active.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D010641:Phenotype; D010704:Phorbols / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000378:metabolism; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives / Q000494:pharmacology*
D000954:Antigens, Surface; D010704:Phorbols; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; C016658:phorbolol myristate acetate; D013755:Tetradecanoylphorbol Acetate
Le phorbol diester induit au niveau de clones de lymphocytes T humains des modifications phénotypiques et fonctionnelles.