On the possibility of cross-resistance between rifampicin and clofazimine in mycobacteria--a laboratory study.
One-way cross-resistance to rifampicin in clofazimine-resistant substrains of Mycobacterium smegmatis ATCC 607 was seen in 4 instances, whereas at most a borderline situation (probably within the experimental error) occurred in this respect with Mycobacterium parafortuitum 16009 and with strains of Mycobacterium "lufu" and Mycobacterium fortuitum. Clofazimine-resistant sub-strains were not isolated from the parental strains of Mycobacterium tuberculosis. Methodological influences (the gradient plate technique was used in this study) are discussed.
D002991:Clofazimine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects* / Q000302:isolation & purification; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D009170:Nontuberculous Mycobacteria / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology*
D002991:Clofazimine; D012293:Rifampin