Tyrosinase-catalyzed conjugation of dopa with glutathione.
A convenient method is described for the preparation of 5-S- and 2-S-glutathionyldopa, based on tyrosinase oxidation of dopa in the presence of glutathione. The yields of 5-S, 2-S, and 6-S isomers produced were about 76, 12, and 5%, respectively.
D003548:Cysteinyldopa / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D005978:Glutathione / Q000031:analogs & derivatives*; D007536:Isomerism; D014442:Monophenol Monooxygenase
D003548:Cysteinyldopa; C033574:glutathionyldopa; D004295:Dihydroxyphenylalanine; D014442:Monophenol Monooxygenase; D005978:Glutathione