Effect of pertussis toxin on water metabolism in the rat.
Pertussis toxin administered to rats resulted in a polyuric state that was due to enhanced renal water excretion. Pertussis toxin also induced a defect in renal water conservation. These abnormalities in renal water excretion could not be attributed to polydipsia, impaired synthesis and/or release of arginine vasopressin or renal tubular dysfunction with solute diuresis. No evidence of pertussis toxin-induced renal tubular damage was present. These results indicate that pertussis toxin induces nephrogenic diabetes insipidus and this defect occurs at the level of the renal collecting tubule.
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001834:Body Water / Q000378:metabolism*; D004231:Diuresis; D004326:Drinking / Q000187:drug effects; D007684:Kidney Tubules / Q000503:physiopathology; D009318:Natriuresis; D009994:Osmolar Concentration; D037342:Pertussis Toxin; D011188:Potassium / Q000652:urine; D051381:Rats; D014556:Urine; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D010566:Virulence Factors, Bordetella; D001127:Arginine Vasopressin; D037342:Pertussis Toxin; D011188:Potassium