Hemophagocytosis simulating malignant histiocytosis: a terminal event of the myelodysplastic syndrome.
We describe a patient with hemophagocytic syndrome resembling malignant histiocytosis which was complicating myelodysplastic disease of 3 years duration. Detailed morphological and ultrastructural studies indicate that the histiocytic component did not demonstrate features of malignancy. A review of other known malignancies ending up in the hemophagocytic syndrome is given, and the significance of this syndrome is discussed.
D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000175:diagnosis*; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology; D010587:Phagocytosis