title: Reaction of cimetidine with Fenton reagent. A biomimetic model for the mixed-function oxidase drug metabolism.
abstract: Cimetidine sulfoxide, N-desmethylcimetidine, N-desmethylcimetidine sulfoxide, cimetidine guanylurea, and the 5-hydroxymethylimidazole derivative of cimetidine sulfoxide were isolated from the reaction of cimetidine with Fenton reagent. The product distribution from the reaction of cimetidine with Fenton reagent clearly simulates the metabolism of cimetidine by the mixed-function oxidase.
mesh_terms: D002927:Cimetidine; D006861:Hydrogen Peroxide; D007501:Iron; D009682:Magnetic Resonance Spectroscopy; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D008956:Models, Chemical
chemical_list: C045076:Fenton's reagent; D002927:Cimetidine; D006861:Hydrogen Peroxide; D007501:Iron; D006899:Mixed Function Oxygenases