[Prolonged survival of skin allografts in rats by injection of serum or a serum fraction extracted from pregnant rats].
This work report the partial purification of an alpha 2-macroglobulin present in the serum of allopregnant rats. Ultrogel filtration followed by immune absorption on different antisera were used giving a single band on polyacrylamide gel electrophoresis. This fraction was able to inhibit in vitro T cell cytotoxic response to allogenic cells. When administered repeatedly to rats it significantly increased the survival of skin allograft. This alpha 2-macroglobulin fraction isolated from allopregnant rats was denominated IRG to its graft rejection inhibitory activity.
D000818:Animals; D005260:Female; D006082:Graft Enhancement, Immunologic; D007108:Immune Tolerance; D008297:Male; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000276:immunology* / Q000302:isolation & purification; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013997:Time Factors
D011257:Pregnancy Proteins
Survie prolongée d'allogreffes de peau chez le rat par injection de sérum ou d'une fraction sérique (IRG) extraite de rattes.