title: Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program.
abstract: Results from Drosophila mutagenicity tests of 45 chemical compounds assayed for the National Toxicology Program are presented. Nine compounds were judged positive and four equivocal in the sex-linked recessive lethal test. The nine positive compounds were acetin, allyl glycidyl ether, cyclophosphamide, 1,2-dibromo-3-chloropropane, 2,3-dibromo-1-propanol, dimethylcarbamyl chloride, 1,2-epoxy-butane, lasiocarpine, and N-nitrosopiperidine. The results for chloral hydrate, maleic hydrazide, propantheline bromide, and trifluralin were equivocal. Of the nine compounds positive in recessive lethal induction, only two--allyl glycidyl ether and dimethylcarbamyl chloride--failed to induce translocations. The remaining 32 were judged to be nonmutagenic under the conditions used.
mesh_terms: D000818:Animals; D002273:Carcinogens; D004331:Drosophila melanogaster / Q000187:drug effects*; D005804:Genes, Lethal; D008040:Genetic Linkage; D008297:Male; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens; D012730:Sex Chromosomes; D013091:Spermatogenesis / Q000187:drug effects; D014178:Translocation, Genetic
chemical_list: D002273:Carcinogens; D009153:Mutagens