The satiety effect of growth hormone-releasing factor in rats.
The effect of growth hormone-releasing factor (GRF) on feeding behavior in rats was examined. Starvation-induced feeding was suppressed by intraventricular administration of 1 nmol and 4 nmol of synthetic human GRF (hGRF). Food intake was not affected when the peptide was administered by intraperitoneal injection. Furthermore, centrally administered hGRF also suppressed feeding in hypophysectomized rats. These results suggest that GRF suppression of food intake is mediated through the central nervous system independent of its effect on pituitary growth hormone secretion.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*; D012528:Satiety Response / Q000187:drug effects*; D013217:Starvation
D013007:Growth Hormone-Releasing Hormone