Relationship between plasma concentrations of clonidine and mean arterial pressure during an accidental clonidine overdose.
The time course of toxicity in a 28 year old man following a 100 mg accidental overdose of clonidine hydrochloride is compared with the decline of plasma clonidine over 5 days. The concentration data were analyzed by nonlinear least squares regression, and fitted to a model which dissociated the blood pressure effects into pressor and depressor components. According to this analysis, there appeared to be two phases of toxicity over time--a hypertensive, and a hypotensive phase. The hypotensive and the hypertensive phases may result primarily through differential stimulation of central alpha 2-, alpha 1-, and vascular post-synaptic alpha 2-adrenoceptors as plasma concentrations fall.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D003000:Clonidine / Q000097:blood* / Q000506:poisoning; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male
D003000:Clonidine