Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene.
The carcinogenicity of a potent mutagen, 1,6-dinitropyrene (1,6-DNP), was examined by intratracheal instillation into non-inbred Syrian golden hamsters of both sexes. Animals were treated with 0.5 mg of 1,6-DNP suspended in 0.2 ml of saline intratracheally once a week for 26 weeks. Lung carcinomas developed in experimental weeks 20-48 in 100 and 90%, respectively, of the male and female hamsters treated with 1,6-DNP. Besides lung carcinomas, myeloid leukemias developed in 60% of both males and females treated with 1,6-DNP. No tumors were found in control hamsters.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D011721:Pyrenes
D002273:Carcinogens; D011721:Pyrenes; C033309:1,6-dinitropyrene