[Morphologic and biochemical study of the functional state of the adrenal cortex in the rat during prolonged hypokinesia].
Female rats exposed to 3-month hypokinesia were used to study adrenal morphology and plasma corticosterone. Prolonged hypokinesia (60-90 days) led to a dissociation between adrenal hypertrophy and lower corticosterone content in plasma. During hypokinesia rats were also exposed to an additional stress-effect, i.e. 5-hour immobilization. This approach showed that in the course of 90-day hypokinesia the adrenal cortex retained its ability to react to an acute stress by an enhanced corticosteroid secretion. Moreover, in response to stress-effects of identical strength and duration the experimental adrenals produced more corticosterone than the controls with no structural rearrangement or de-lipoidization.
D000222:Adaptation, Physiological; D000302:Adrenal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D005260:Female; D050356:Lipid Metabolism; D009068:Movement; D009929:Organ Size; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D003345:Corticosterone
Morfologicheskoe i biokhimicheskoe issledovanie funktsional'nogo sostoianiia kory nadpochechnikov krys pri dlitel'noĭ gipokinezii.