Metabolism of D(-)lactic acid in rats given high intragastral doses.
In rats given D[u-14C]-labelled DL-lactate with 3.8-13.4 mmol D-lactate per kg 0.75 by stomach tube, the exhalation of CO2 produced from and the renal excretion of D-lactate and metabolites were measured. Exhalation of D-lactate-C accounted for 45-30% of the dosage given with a decreasing proportion at higher doses. The renal excretion of D-lactate averaged 0.9% and that of metabolites from D-lactate 2.4% of the doses given. The fraction of unrecovered D-lactate accounted for about 54-68% of the doses given and increased with doses. The time course of D-lactate oxidation indicated a maximum rate of about 1.5 mmol C per kg 0.75 in 1 hr which was reached at 1 hr after infusion at the earliest and extended up to 8 hr if high doses were given.
D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D002250:Carbon Radioisotopes; D005260:Female; D007441:Intubation, Gastrointestinal; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000008:administration & dosage / Q000378:metabolism*; D019344:Lactic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D002250:Carbon Radioisotopes; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D007770:L-Lactate Dehydrogenase