[Demonstration of 2-5A synthetase in human circulating mononuclear cells after oral administration of an interferon inducer isolated from a fraction of Escherichia coli and Klebsiella pneumoniae].
Evaluation of the activity of an enzyme activated by interferon (2'-5' oligo-isoadenylate synthetase or 2-5A synthetase) has been used to determine, in man, the interferon inducing capacity of a fraction isolated from Escherichia coli and Klebsiella pneumoniae, SL04, an immunomodulating agent administrated per os. An increase of the activity of this enzyme has been shown in four out of five volunteers following a single oral administration of 100 mg of SL04. This activation demonstrated in humans confirms the pharmacological results of the interferon induction obtained with SL04 in vivo in mice and in vitro in human cell cultures.
D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood*; D000284:Administration, Oral; D000328:Adult; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006801:Humans; D007369:Interferon Inducers / Q000008:administration & dosage / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D007711:Klebsiella pneumoniae / Q000276:immunology*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology*
D007369:Interferon Inducers; D015088:2',5'-Oligoadenylate Synthetase
Mise en évidence de la 2-5A synthétase dans les cellules mononuclées circulantes chez l'Homme après administration orale d'un inducteur d'interféron présent dans une fraction issue d'Escherichia coli et Klebsiella pneumoniae.