Inhibition of arachidonic acid metabolism by antipyrine and 4-aminoantipyrine.
Antipyrine and 4-aminoantipyrine are used to determine uterine and umbilical blood flows. When administered in vivo, these compounds produce a decrease in uterine contracture activity and maternal uterine vein 13,14-dihydro-15-keto-prostaglandin F2 alpha concentrations. In this paper we report that they also inhibit in vitro activity of prostaglandin synthase in bovine seminal microsomes.
D000675:Ampyrone / Q000494:pharmacology*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001091:Arachidonate Lipoxygenases; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D008297:Male; D012669:Seminal Vesicles / Q000187:drug effects / Q000201:enzymology
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D000675:Ampyrone; D016718:Arachidonic Acid; D001091:Arachidonate Lipoxygenases; D000983:Antipyrine