Effect of 1,25-dihydroxyvitamin D3 and nifedipine on prolactin release in normal man.
In normal man 1,25 (OH)2-vitamin D3 [1,25 (OH)2D] increases both basal and TRH-stimulated prolactinemia; this effect is completely reversible by the calcium antagonist nifedipine. Similarly the 1,25 (OH)2D-induced hypercalcemia is totally inhibited by nifedipine. These findings suggest that both biological effects of 1,25 (OH)2D are mediated by calcium-dependent mechanisms.
D000328:Adult; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D002117:Calcitriol; D009543:Nifedipine; D002118:Calcium