title: Genetic linkage studies in ataxia-telangiectasia: Gm markers.
abstract: Gm marker studies were performed on seven families with ataxia-telangiectasia in order to determine genetic linkage. For statistical analysis, the disorder was assumed to be monogenic. Using LOD scores computed by the program LIPED, tight linkage was excluded at a recombination fraction of less than or equal to 2 cM. This distance (equivalent to approximately two million nucleotides) includes most or all of the 14q32 chromosomal region.
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics*; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007074:Immunoglobulin G / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008126:Lod Score; D008297:Male
chemical_list: D005819:Genetic Markers; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains