Psychoses associated with bupropion treatment.
The authors describe the development of acute psychoses in four patients treated with bupropion, a unicyclic aminoketone antidepressant. In two of the cases the psychoses seemed to be affected by dose. The mechanism responsible for the psychotic reactions is unclear, although it may involve perturbation of dopaminergic systems. On the basis of their experience, the authors offer recommendations regarding the clinical use of bupropion.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016642:Bupropion; D003866:Depressive Disorder / Q000188:drug therapy; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011427:Propiophenones / Q000008:administration & dosage / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology* / Q000503:physiopathology
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion; D004298:Dopamine