title: The generation of dense granules within cultured human retinal pigment epithelial cells at senescence.
abstract: Human retinal pigment epithelial cells routinely lose all forms of pigmentary inclusion when cultured. We report the repigmentation of a senescent population of cells. The pigmented inclusions were found to be neither melanin or lipofuscin but some form of dense membranous lamellae.
mesh_terms: D002470:Cell Survival; D002478:Cells, Cultured; D002675:Child, Preschool; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D006801:Humans; D007849:Laurence-Moon Syndrome / Q000473:pathology; D008854:Microscopy, Electron; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000648:ultrastructure*