Hyperammonemia-induced cytotoxic brain edema under osmotic opening of blood-brain barrier in dogs.
Infusion of an ammonium acetate solution into dogs during mannitol-induced reversible opening of the blood-brain barrier (BBB) resulted in a marked rise in intracranial pressure with exclusion of Evans blue dye. This indicated cytotoxic brain edema. These findings suggest a role for hyperammonemia in cerebral edema during acute liver failure.
D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology; D000641:Ammonia / Q000097:blood*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000139:chemically induced*; D004285:Dogs; D007261:Infusions, Intra-Arterial; D007427:Intracranial Pressure / Q000187:drug effects; D008107:Liver Diseases / Q000503:physiopathology; D008353:Mannitol / Q000008:administration & dosage
D000085:Acetates; D008353:Mannitol; D000641:Ammonia; C018824:ammonium acetate