Delayed-type hypersensitivity responses induced by bovine colostral components.
Transfer factor-type substances obtained from leukocytic cells and fluid portions of bovine colostrum caused effective passive transfer of delayed-type hypersensitivity responses across species barriers. Passive transfer of Brucella abortus sensitivity was obtained with equal regularity when using components derived from peripheral blood and colostrum of dams sensitized at 3 and 9 months of age. Colostral feedings to calves caused the passive transfer of delayed-type hypersensitivity as early as 2 days after parturition. The findings indicated that colostral components were important in the process of cell-mediated immunity.
D000818:Animals; D002003:Brucella abortus / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D002418:Cattle Diseases / Q000276:immunology*; D003126:Colostrum / Q000276:immunology*; D006168:Guinea Pigs / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000662:veterinary*; D007116:Immunization, Passive / Q000662:veterinary*; D012376:Rodent Diseases / Q000276:immunology*; D012882:Skin Tests / Q000662:veterinary