[Carcinogenic hazard of small doses of nitrite in connection with the endogenous synthesis of nitroso compounds].
Carcinogenic risk of small doses of precursors of nitroso compounds, i.e. sodium nitrite (total dose in 0.2-2.0 g/mouse in drinking water) and morpholine (total dose is 0.23 g/mouse in bread) was studied in 520 CBA and 290 C57Bl mice during 96 weeks. It is shown that under these conditions the carcinogenic effect was more pronounced in CBA mice: there was a significant increase in general incidence of tumours, particularly liver tumours and hemoblastoses in CBA females and malignant liver tumours in CBA males.
D000818:Animals; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009025:Morpholines / Q000378:metabolism / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism / Q000633:toxicity*; D009603:Nitroso Compounds / Q000096:biosynthesis* / Q000633:toxicity; D012977:Sodium Nitrite / Q000378:metabolism / Q000633:toxicity
D009025:Morpholines; D009573:Nitrites; D009603:Nitroso Compounds; C037574:morpholine; D012977:Sodium Nitrite
Kantserogennaia opasnost' malykh doz nitrita v sviazi s éndogennym sintezom nitrozosoedineniĭ.