[Comparative characteristics of voluntary and semivoluntary methods of the alcoholization of rats].
Water and ethanol consumption, blood and urine ethanol concentrations were measured in male rats aged 1.5 to 8 months. The animals had ethanol solutions (5-25%) and water as alternate fluid (two-bottle choice) or a 10% ethanol solution as a sole water source. In both cases, the rats did not exceed 7 g/kg of ethanol consumption per day. From 10 a.m. to 16 p.m. the blood ethanol concentration was no more than 0.1 g/l. Ethanol excretion with urine did not go beyond 0.1% of the daily dose. Ethanol consumption was increased by 1-2 g/kg a day if saccharin (0.125%) and sodium chloride (1%) were added to ethanol solution. In this case the withdrawal signs developed after ethanol consumption cessation.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage; D008297:Male; D008722:Methods; D051381:Rats; D012646:Self Administration; D013997:Time Factors; D014868:Water Deprivation
D000431:Ethanol
Sravnitel'naia kharakteristika dobrovol'nykh i poludobrovol'nykh metodov alkogolizatsii krys.