Effects of oral contraceptive steroids (norethisterone/mestranol) on the activities of hepatic drug-metabolizing enzymes in iron-deficient anemic rats.
Either oral contraceptive steroid (norethisterone/mestranol; N/M) treatment or iron-deficiency (Fe(-] anemia alone caused an increase in NADPH cytochrome c reductase and in three hepatic microsomal mixed-function oxidase activities in female rats. When N/M treatment and the Fe(-) diet are combined, no further change in hepatic enzyme activity is seen compared with that with either treatment alone.
D000632:Aminopyrine / Q000378:metabolism; D000747:Anemia, Hypochromic / Q000201:enzymology*; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D006591:Hexobarbital / Q000378:metabolism; D008656:Mestranol / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D009640:Norethindrone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000632:Aminopyrine; D001564:Benzo(a)pyrene; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D008656:Mestranol; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase; D009640:Norethindrone