DR antigens as a guide in the search for Dw homozygous typing cells (HTC).
Advantage has been taken from association between DR and Dw genes in the search for homozygous typing cells (HTC). From population data it was calculated that the probability of Dw homozygosity should be about 10 times higher among persons with one identified DR antigen than in a random population. To prove this assumption cells from 11 persons with one DR antigen were tested in different MLR combinations and 5 from them gave reaction patterns typical for HTC. These cells revealed ability to discriminate between high and low MLR responses as indicated by the bimodal or asymmetric curves of distribution of the results.
D000483:Alleles; D002455:Cell Division; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006720:Homozygote; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D008297:Male
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II