title: Phospholipid and ether linked phospholipid content alter with cellular resistance to vinblastine.
abstract: The phospholipid and ether linked phospholipid content of leukaemic lymphocytes alters when the cells become resistant to low levels of the anti-cancer drug, vinblastine. Sphingomyelin and cardiolipin increase, and phosphatidyl ethanolamine and serine decrease in resistant cells. In addition, increases in 1-alkyl-2-acyl phosphatidyl choline and 1-alkenyl-2-acyl-phosphatidyl ethanolamine are concomitant with decreased 1,2-diacyl phosphatidyl choline and ethanolamine. Changes to the ultrastructure of the inner half of the plasma membrane bilayer, as a consequence of drug resistance, are illustrated by freeze-fracture electron microscopy.
mesh_terms: D001665:Binding Sites; D002308:Cardiolipins / Q000378:metabolism; D002460:Cell Line; D046508:Culture Techniques; D004351:Drug Resistance; D004987:Ethers / Q000378:metabolism; D005614:Freeze Fracturing; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D013109:Sphingomyelins / Q000378:metabolism; D014747:Vinblastine / Q000494:pharmacology*
chemical_list: D002308:Cardiolipins; D004987:Ethers; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D013109:Sphingomyelins; D012694:Serine; D014747:Vinblastine