Schistosoma mansoni: reduced efficacy of chemotherapy in infected T-cell-deprived mice.
The effect of host immunosuppression on the efficacy of schistosomicidal chemotherapy has been tested in T-cell-deprived CBA mice infected with Schistosoma mansoni. The drugs hycanthone, oxamniquine, and praziquantel were found to kill fewer adult S. mansoni worms in deprived mice than in comparably infected strain-, age-, and sex-matched, immunologically intact controls. Inconsistent results were obtained with niridazole, and amoscanate was as effective in deprived mice as in controls. The possibility that hycanthone, oxamniquine, praziquantel, and previously studied antimony act synergistically with immune effector mechanisms in killing adult schistosomes is discussed.
D000818:Animals; D000961:Antilymphocyte Serum; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006826:Hycanthone / Q000627:therapeutic use; D017879:Isothiocyanates; D051379:Mice; D008808:Mice, Inbred CBA; D010073:Oxamniquine / Q000627:therapeutic use; D011223:Praziquantel / Q000627:therapeutic use; D012550:Schistosoma mansoni; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013861:Thiocyanates / Q000627:therapeutic use; D013934:Thymectomy
D000961:Antilymphocyte Serum; D017879:Isothiocyanates; D013861:Thiocyanates; D010073:Oxamniquine; D006826:Hycanthone; D011223:Praziquantel; D004159:Diphenylamine; C012391:amoscanate