title: Structure-related effect of pH on the bioassay sensitivity of five thiadiazole cephalosporins (a note).
abstract: Using the buffered disc agar-diffusion method with Bacillus subtilis as test organism' a direct relationship was found between the pH, incubation temperature and the structure-dependent activity of five thiadiazole cephalosporins. This appears to be related to the ionizable group(s) of the molecules.
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D002511:Cephalosporins / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: D002511:Cephalosporins