Persistence and progression of immunologic abnormalities in haemophilia.
Immunologic parameters in 51 patients with haemophilia treated with cryoprecipitate from volunteer donors or with commercial lyophilized concentrate were studied on 2-7 occasions. Concentrate users had significantly decreased mean T4 (helper)/T8 (suppressor) lymphocyte ratios when the initial (1.5 +/- .43) and most recent (1.25 +/- .60) values were compared (p less than .001), whereas in cryoprecipitate users mean values remained normal. Of the 22 concentrate users with initially normal T4/T8 ratios, 10 became abnormal during the study, an incidence of 45%. Fifteen of 28 (54%) patients with abnormal T4/T8 ratios had elevated circulating immune complexes (CIC), whereas all 16 patients with normal T4/T8 ratios had normal levels of CIC. Six patients have persistent lymphadenopathy.
D000954:Antigens, Surface / Q000032:analysis; D001772:Blood Cell Count; D001793:Blood Preservation; D001803:Blood Transfusion; D005169:Factor VIII / Q000037:antagonists & inhibitors; D005455:Fluorescent Antibody Technique; D005615:Freezing; D006467:Hemophilia A / Q000150:complications / Q000276:immunology*; D006801:Humans; D007154:Immune System Diseases / Q000150:complications*; D007074:Immunoglobulin G / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010976:Platelet Count
D000954:Antigens, Surface; D007074:Immunoglobulin G; D005169:Factor VIII