title: Responsiveness of oxytocin-producing neurons to acute salt loading in rats: comparisons with vasopressin-producing neurons.
abstract: Plasma oxytocin-associated neurophysin concentration [( OT-RNP]) was used to evaluate the responsiveness of oxytocinergic neurons to an acute salt load in Long-Evans (LE) rats and Brattleboro homozygous (DI) rats. This responsiveness was compared with that of vasopressinergic neurons in LE rats as indexed by plasma vasopressin-associated neurophysin concentration [( VP-RNP]). Acute salt loading was induced by infusing 18% saline for 60 min into conscious, trained, chronically catheterized animals and plasma osmolality (Posm) and mean arterial pressure (MAP) were monitored. An increase in Posm was associated with a rise in [OT-RNP] and the relationship between delta [OT-RNP] and delta Posm was similar for both LE and DI rats over the first 40 min of infusion (21.6 and 19.7 fmol ml-1 mosm-1 kg-1, respectively). Although Posm continued to rise between 40 and 60 min infusion, [OT-RNP] actually fell slightly during this period in LE rats to a final elevation of 682 +/- 40 fmol/ml above initial values whereas [OT-RNP] in DI rats continued to rise to a final elevation of 1,927 +/- 288 fmol/ml above initial values at 60 min of infusion. The differences between these elevations at 60 min for LE and DI rats were highly significant (p less than 0.001). For LE rats, the increase of [OT-RNP] with Posm for the first 40 min of infusion was much greater than the increase in [VP-RNP] with the slope between delta [VP-RNP] and delta Posm being only 8.3 compared to 21.6 fmol ml-1 mosm-1 kg-1 in the case of delta [OT-RNP].(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006973:Hypertension / Q000209:etiology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009481:Neurophysins / Q000097:blood; D009994:Osmolar Concentration; D010121:Oxytocin / Q000096:biosynthesis* / Q000097:blood; D051381:Rats; D011910:Rats, Brattleboro; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D014667:Vasopressins / Q000096:biosynthesis* / Q000097:blood
chemical_list: D009481:Neurophysins; D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D012965:Sodium Chloride; D010121:Oxytocin