Increased beta-aminoisobutyric acid in rat liver with 6-azauracil and its enantiomer.
When 6-azauracil was subcutaneously injected, beta-aminoisobutyric acid and beta-alanine contents were increased 22 and 61-fold, respectively, in rat liver. Incorporation of [methyl-14C]thymine into beta-aminoisobutyric acid was increased to 42-fold by 6-azauracil treatment. The absolute configuration of this amino acid was proved to be the (R)-form by means of a gas-chromatographic technique. 6-Azauracil inhibited beta-alanine-pyruvate aminotransferase activity with an I50 of approx. 2.5 mM.
D000621:Aminoisobutyric Acids / Q000032:analysis*; D000818:Animals; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013941:Thymine / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015091:beta-Alanine / Q000378:metabolism
D000621:Aminoisobutyric Acids; D015091:beta-Alanine; D014498:Uracil; C100248:azauracil; D013941:Thymine; C033435:3-aminoisobutyric acid