[Organ distribution of ruthenocenyl biogenic amine derivatives--radiodiagnostic agents for the adrenals and ovaries?].
The organ distribution of 103Ru labelled ruthenocenyl derivatives of tyramine, histamine, benzylamine, phenylethylamine and homoveratrylamine were measured in rats. The derivatives of tyramine, histamine and benzylamine showed a high affinity for the adrenal and ovar. Adrenal/muscle ratios up to 2000:1 were gained but only if the dose was administered i.v. and was below 0.1 mumol/kg. The ruthenocenyl derivatives of tyramine labelled with 103Ru in the ruthenocene moiety or with 14C in the tyramine moiety showed a parallel distribution pattern but completely different from the distribution of 103RuCl3. This indicates that the tyramine derivatives are not destroyed in the body yielding Ru-ions. The advantages of the ruthenocenyl derivatives in comparison with the known amphetamine derivatives labelled with radioactive iodine are discussed.
D000311:Adrenal Glands / Q000000981:diagnostic imaging*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D003287:Contrast Media / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000378:metabolism*; D010053:Ovary / Q000000981:diagnostic imaging*; D011859:Radiography; D011868:Radioisotopes / Q000378:metabolism; D051381:Rats; D012428:Ruthenium / Q000378:metabolism*; D014018:Tissue Distribution
D001679:Biogenic Amines; D003287:Contrast Media; D009942:Organometallic Compounds; D011868:Radioisotopes; C016721:ruthenocene; D012428:Ruthenium
Organverteilung von Ruthenocenylderivaten biogener Amine--Radiodiagnostika für Nebenniere und Ovar?