Age-related changes of proteoglycan subunits from sheep nasal cartilage.
Proteoglycan subunits of sheep nasal cartilage from animals of five different ages were studied. There is a continuous reduction in the size and chondroitin sulphate content of the aggregable and non-aggregable subunits with ageing. For each age group, the non-aggregable are poorer in protein and keratan sulphate than the corresponding aggregable molecules. Irrespective of age, the amount of proteoglycan protein extracted from each gramme wet cartilage is the same. The amino acid composition and the proportion of the aggregable proteoglycans are also the same.
D000375:Aging; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002356:Cartilage / Q000378:metabolism*; D002499:Centrifugation, Density Gradient; D002809:Chondroitin Sulfates / Q000378:metabolism; D002850:Chromatography, Gel; D006820:Hyaluronic Acid / Q000494:pharmacology; D007632:Keratan Sulfate / Q000378:metabolism; D046911:Macromolecular Substances; D011506:Proteins / Q000378:metabolism; D011509:Proteoglycans / Q000032:analysis / Q000378:metabolism*; D012756:Sheep
D000596:Amino Acids; D046911:Macromolecular Substances; D011506:Proteins; D011509:Proteoglycans; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate