Some interleukin-3 dependent mast-cell lines also respond to interleukin-2.
The haemopoietic stem cell line 32D cl-23 is alcian blue positive, Lyt 1+, and requires a growth factor, interleukin-3 (IL-3). This cell has now been shown to respond to interleukin-2 (IL-2). Antibodies directed against the murine interleukin-2 receptor blocked 3H-thymidine incorporation by 32D cl-23 cells grown in interleukin-2, but had no effect on 32D cl-23 in interleukin-3. Thus the receptor for interleukin-2 on 32D cl-23 cells may be similar to the interleukin-2 receptor on murine T cells. Similar results were obtained using a different basophil cell line 32D cl-5, but not using another basophil cell line, Rotundi, or factor dependent musocal type mast cells (P cells) derived from spleen.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology* / Q000302:isolation & purification; D007377:Interleukin-3; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000494:pharmacology*; D008407:Mast Cells / Q000166:cytology / Q000276:immunology*; D051379:Mice; D011971:Receptors, Immunologic / Q000276:immunology; D015375:Receptors, Interleukin-2; D013601:T-Lymphocytes / Q000276:immunology
D007376:Interleukin-2; D007377:Interleukin-3; D008222:Lymphokines; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2