title: [Transmissible formaldehyde resistance in Serratia marcescens].
abstract: It was possible to isolate a strain of Serratia marcescens from fresh clinical bacterial isolates which was 4-6 times more resistant against formaldehyde than other strains. It was shown that the strain harbours two plasmids with molecular sizes of 58- and 90 Mdal. It was demonstrated by conjugation-, transformation- and plasmid-curing experiments that the formaldehyderesistance is plasmid mediated and transferable to E. coli. It was shown by labelling with 14C-formaldehyde that the resistant strains bind much more formaldehyde than the sensible strains.
mesh_terms: D004202:Disinfectants / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005557:Formaldehyde / Q000494:pharmacology*; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011815:R Factors / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects* / Q000235:genetics; D014169:Transformation, Bacterial / Q000187:drug effects
chemical_list: D004202:Disinfectants; D005557:Formaldehyde
vernacular_title: Ubertragbare Formaldehydresistenz bei Serratia marcescens.