title: [Controlled trial and cost/efficacy evaluation of the prevention of infectious complications in surgery of cancers of the upper aerodigestive tract with peri-operative cefoxitin].
abstract: Major surgery of the cancers of the upper aerodigestive tract involves a high risk of post operative infection. We report the results of a clinical controlled trial aimed to evaluate the effectiveness and the cost of the prevention of post operative infections by peri operative cefoxitin. These results show a significant difference in favor of the treated group when considering the local infection rate (15% versus 80%) the length of healing, as well as the direct costs related to the antibiotherapy. These results have been confirmed by a further study.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D002440:Cefoxitin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000601:surgery; D010610:Pharyngeal Neoplasms / Q000601:surgery*; D011292:Premedication / Q000191:economics*
chemical_list: D002440:Cefoxitin
vernacular_title: Essai contrôlé et évaluation coût/efficacité de la prévention des complications infectieuses de la chirurgie des cancers des voies aéro-digestives supérieures par la céfoxitine péri-opératoire.