Vascular diversion in chemotherapy of brain tumors.
Of the patients with malignant gliomas treated by arterial infusion of chemotherapeutic agents at one institution, tumor extension beyond the territory supplied by a single internal carotid artery was documented at operation or by computed tomography or angiography in 55%. In 47% of the patients, a surgical procedure was performed to modify the cerebral circulation so that the entire lesion could be treated by infusing a single internal carotid artery. This report examines the anatomical and radiological background for these procedures, and the surgical options, techniques, and complications in this series of patients.
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002339:Carotid Arteries; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002533:Cerebral Angiography; D002548:Cerebral Revascularization; D002941:Circle of Willis / Q000601:surgery; D005910:Glioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents