Syntheses of carbon-11 labelled ornithine and lysine. Preliminary accumulation studies in rats with Walker 256 carcinosarcoma.
DL-[1-11C]ornithine and lysine have been synthesized by carboxylation of the corresponding alpha-lithioisocyanide with a radiochemical yield of up to 14% without correction for decay. The total preparation time is 50 min. Accumulation of both DL-[1-11C]ornithine and lysine in Walker 256 carcinosarcoma is observed, with a tumor/non-tumor ratio of 4.9 and 4.5 respectively, at 45 min after intravenous injection.
D000818:Animals; D002250:Carbon Radioisotopes; D002279:Carcinoma 256, Walker / Q000000981:diagnostic imaging*; D005260:Female; D007553:Isotope Labeling / Q000379:methods; D008239:Lysine; D008297:Male; D009368:Neoplasm Transplantation; D009952:Ornithine; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D009952:Ornithine; D008239:Lysine