Occlusion and reperfusion as possible different mechanisms of ventricular tachyarrhythmias in Prinzmetal's variant angina.
A case of a patient with variant angina associated with severe ventricular tachyarrhythmias studied by continuous electrocardiographic and haemodynamic monitoring is reported. Severe ventricular arrhythmias developed both during maximal ST-segment elevation, in association with haemodynamic signs of acute ischaemic cardiac dysfunction and after nitroglycerin-induced reversion of ischaemia and return of the haemodynamic variables to the basal state. Thus, in this patient, ventricular arrhythmias during acute ischaemia could be related not only to acute vasospastic coronary occlusion but probably also to reperfusion after relief of coronary spasm.
D000788:Angina Pectoris, Variant / Q000188:drug therapy / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D003329:Coronary Vasospasm / Q000503:physiopathology; D004562:Electrocardiography; D004874:Ergonovine / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D005996:Nitroglycerin / Q000627:therapeutic use; D011651:Pulmonary Artery / Q000187:drug effects; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy / Q000503:physiopathology*
D005996:Nitroglycerin; D009543:Nifedipine; D004874:Ergonovine