title: beta-Chloro-L-alanine inhibition of the Escherichia coli alanine-valine transaminase.
abstract: beta-Chloro-L-alanine, an amino acid analog which inhibits a number of enzymes, reversibly inhibited the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, accounted for the isoleucine-plus-valine requirement of E. coli in the presence of beta-chloro-L-alanine.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D004926:Escherichia coli / Q000201:enzymology* / Q000254:growth & development; D007532:Isoleucine / Q000378:metabolism; D000637:Transaminases / Q000037:antagonists & inhibitors*; D014633:Valine / Q000378:metabolism; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D007532:Isoleucine; D015091:beta-Alanine; C006977:3-chloroalanine; D000637:Transaminases; C019798:branched-chain-amino-acid transaminase; C034522:valine-pyruvate transaminase; D014633:Valine; D000409:Alanine