[Effect of rutin and esculamine on models of aseptic inflammation].
It was shown in experiments on rats that intraabdominal administration of silver nitrate solution induces peritonitis and the subplantar administration of histamine, serotonin and prostaglandin E2 leads to an acute paw edema. Preliminary subcutaneous administration of esculamine or rutin inhibited the development of the inflammation. Esculamine proved more active here.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004929:Esculin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005419:Flavonoids / Q000627:therapeutic use*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010538:Peritonitis / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012431:Rutin / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D004929:Esculin; C001158:esculamine; D012431:Rutin
Vliianie rutina i éskulamina na nekotorye modeli aspeticheskogo vospaleniia.