Is the jaw-opening reflex a valid model of pain?
Tooth pulp shock does not produce only pain; low intensity stimulation results in a non-painful sensation that is termed pre-pain. In animals low intensity tooth pulp shock does not evoke escape behavior; the similarity of the animal escape/detection threshold ratio with the human pain/pre-pain threshold ratio is evidence that pre-pain and pain may be present in animals as in humans. Both pre-pain and pain may arise from the activation of a common afferent modality. The TP-JOR does not correlate with the degree of pain experienced under all conditions. The TP-JOR threshold is at or near the sensory detection threshold, at stimulation intensities which evoke pre-pain. Under normal conditions both the magnitude of the TP-JOR response and the degree of pain experienced increase with increasing stimulation intensity. The TP-JOR and the tooth pulp-evoked pain are affected in parallel by sensory habituation and both appear to relay in the rostral trigeminal complex. There are no cases where the TP-JOR is suppressed and pain is still experienced from tooth pulp shock; the suppression of the TP-JOR may therefore be an accurate index of analgesia. However, in humans treatments that produce analgesia have not been shown to produce suppression of the TP-JOR. Thus, the TP-JOR that persists following analgesic treatments is not a reliable index of either analgesia or pain.
D000698:Analgesia; D000818:Animals; D002415:Cats; D003782:Dental Pulp / Q000294:innervation; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004924:Escape Reaction / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D000882:Haplorhini; D006801:Humans; D008410:Masticatory Muscles; D009475:Neurons, Afferent / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D012018:Reflex; D012684:Sensory Thresholds