Effects of intrahypothalamically administered norepinephrine, serotonin and bombesin on thermoregulation in the deermouse (Peromyscus maniculatus).
Norepinephrine, serotonin, and bombesin administered intrahypothalamically affected thermoregulation in the deermouse, Peromyscus maniculatus. At a Ta of 22 degrees C, doses of 3 micrograms and 6 micrograms of NE resulted in transient hypothermia (maximum drop of 1.6 +/- 1.0 degrees C and 4.3 +/- 2.3 degrees C, respectively). A 1.5 microgram dose of 5-HT induced a persistent hyperthermia (maximum increase of 1.8 +/- 0.8 degrees C) which persisted for more than 2 h. A 6 microgram dose of 5-HT did not produce any significant effects. At a Ta of 22 degrees C, doses of 1 ng and 10 ng of bombesin produced a transient hyperthermia (maximum increase of 1.8 +/- 0.3 degree C and 2.1 +/- 1.2 degrees C, respectively) immediately postinjection. At a Ta of 5 degrees C, a 1 ng dose of bombesin resulted in a prolonged hypothermia (maximum decrease of 2.0 +/- 0.4 degrees C), while a 10 ng dose of bombesin produced a hyperthermic response (maximum increase of 1.3 +/- 0.8 degree C) at 2 h postinjection.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D005260:Female; D007032:Hypothalamus, Anterior / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009638:Norepinephrine / Q000494:pharmacology*; D010542:Peromyscus; D011301:Preoptic Area / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D001839:Bombesin; D009638:Norepinephrine