Antibacterial activity in vitro of sulbenicillin against mucoid and non-mucoid strains of Pseudomonas aeruginosa.
The in vitro antibacterial activity of sulbenicillin against a number of mucoid and non-mucoid strains of Pseudomonas aeruginosa was investigated and compared with that of some other beta-lactam antibiotics. From the data reported it is evident that sulbenicillin showed better anti-microbial activity than carbenicillin in almost all the tests run. Sulbenicillin appears to have a somewhat lower activity than piperacillin and cefotaxime; however, cefotaxime and particularly piperacillin are highly conditioned by the inoculum size and have a less favourable MBC to MIC ratio.
D000667:Ampicillin / Q000494:pharmacology; D002228:Carbenicillin / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D003550:Cystic Fibrosis / Q000382:microbiology; D006801:Humans; D008722:Methods; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013408:Sulbenicillin / Q000494:pharmacology*
D000667:Ampicillin; D002228:Carbenicillin; D002439:Cefotaxime; D013408:Sulbenicillin; D010400:Penicillin G; D010878:Piperacillin