[Damage to the liver DNA of rats during the endogenous synthesis of N-nitrosodimethylamine].
The damage of liver DNA formation during endogenic synthesis of N-nitrosodimethylamine (NDMA) have been studied after introduction of its precursors, dimethylamine, amidopyrine and sodium nitrite, into the rat stomach. A combined administration of various doses of dimethylamine and nitrite increased the amount of single-strand DNA from 3.0 to 11.3%. The maximum DNA damage after administration of the precursors was observed after 24 h, and after 48 h it decreased to the control level. Pretreatment of rats with dimethylamine or nitrite increased the DNA damage induced by NDMA formation (37.4% and 41.6%, respectively).
D000478:Alkylation; D000632:Aminopyrine / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism; D004123:Dimethylamines / Q000378:metabolism / Q000494:pharmacology; D004128:Dimethylnitrosamine / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D012977:Sodium Nitrite / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors
D004277:DNA, Single-Stranded; D004123:Dimethylamines; D000632:Aminopyrine; D004247:DNA; C034516:dimethylamine; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine
Povrezhdenie DNK pecheni krys pri éndogennom sinteze N-nitrozodimetilamina.