[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct].
The experiments on rats with a 3-day myocardial infarction caused by the left coronary artery ligation have shown that multiple lidocaine and pyromecaine injections according to a given scheme decrease the size of the necrosis area. Drug effects were not related to their action on the blood supply of the ischemic area.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011433:Propranolol / Q000627:therapeutic use; D011759:Pyrrolidines / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D011759:Pyrrolidines; C000661:bumecain; D008012:Lidocaine; D011433:Propranolol
Vliianie lidokaina i piromekaina na razmer éksperimental'nogo infarkta miokarda.