Bromocriptine and sulpiride competitively inhibit estrogen binding to its receptor in the adrenal gland.
Bromocriptine and sulpiride incubated simultaneously with [3H]-estradiol in the cytosol from adrenal glands of adult male rats, yielded curves typical of competitive inhibition as analyzed by Lineweaver-Burk plots. The inhibition constant for both drugs was approximately 10(8) M-1, only 10 times lower than the association constant for estradiol.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D001971:Bromocriptine / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000187:drug effects / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D001971:Bromocriptine; D004958:Estradiol; D013469:Sulpiride