Ocular anti-inflammatory action of a lipoxygenase inhibitor in the rabbit.
Among all lipoxygenase inhibitors studied, REV 5901 was found to be the most potent one to reduce lens protein-induced ocular inflammation in rabbits. It reduced ocular inflammation effectively by either injection into the ear vein (10 mg/kg) (65% inhibition) or topical administration (50 microliters of 5% ointment) (40% inhibition). Local administration was less effective than intravenous injection presumably because of slower drug delivery into the eyes.
D000818:Animals; D009877:Endophthalmitis / Q000188:drug therapy*; D005260:Female; D006912:Hydroxyquinolines / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D016859:Lipoxygenase Inhibitors; D009883:Ophthalmic Solutions; D011804:Quinolines; D011817:Rabbits
D006912:Hydroxyquinolines; D016859:Lipoxygenase Inhibitors; D009883:Ophthalmic Solutions; D011804:Quinolines; C049740:alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol