title: Selection for growth alters the feeding response to injections of biogenic amines.
abstract: Two experiments were conducted to determine if selection for growth altered the response to intracerebroventricular (ICV) injections of methoxamine and 5-hydroxytryptamine (5-HT). Lines of chickens divergently selected over 25 generations for 8-week body weight were used. The ICV injection of methoxamine into fully fed birds significantly increased food intake in the high-weight line but had no effect on food intake in the low-weight line. Conversely, the ICV injection of 5-HT had no effect in fully fed birds but significantly decreased food intake in 24-hr fasted birds in both weight-lines. Food intake was affected by 5-HT for a much longer period in the high-weight line than in the low-weight line. These results suggest that selection for growth alters the brain response to biogenic amines.
mesh_terms: D000818:Animals; D001679:Biogenic Amines / Q000494:pharmacology*; D001835:Body Weight; D002645:Chickens / Q000254:growth & development*; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D001679:Biogenic Amines; D012701:Serotonin; D008729:Methoxamine