[Plasma assay of somatocrinin during growth hormone stimulation tests. Results in pediatrics].
Somatocrinin (GHRH) levels were measured by RIA in the plasma of 41 children with constitutionally short stature. Basal plasma GHRH level was 51 +/- 10 pg/ml. L-Dopa induced a two fold increase in circulating GHRH levels 30 to 45 minutes before the elevation of GH. A positive correlation (p less than 0.005) was found between the peak of GH and GHRH levels during the dopaminergic stimulus. Conversely, the secretion of GH induced by amino-acids or clonidine was not preceded by an elevation of GHRH. These results suggest that the various stimulations of GH secretion used for investigations of short stature do not act in the same way at the hypothalamo-pituitary level.
D000596:Amino Acids / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000494:pharmacology; D006130:Growth Disorders / Q000097:blood*; D013006:Growth Hormone / Q000378:metabolism; D013007:Growth Hormone-Releasing Hormone / Q000097:blood*; D006801:Humans; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology; D010901:Pituitary Function Tests; D011863:Radioimmunoassay; D013268:Stimulation, Chemical
D000596:Amino Acids; D007980:Levodopa; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D003000:Clonidine
Dosage plasmatique de la somatocrinine (GHRH) au cours des épreuves de stimulation de l'hormone de croissance. Résultats en pédiatrie.