Indoprofen, a non-steroidal anti-inflammatory analgesic which does not depress respiration in normal man. A study comparing indoprofen with morphine.
The respiratory effects of intravenous indoprofen 400 mg, a highly effective non-steroidal anti-inflammatory analgesic, were compared with those of morphine 10 mg in 10 healthy volunteers. Morphine exhibited its characteristic adverse respiratory depressant properties, Indoprofen, in contrast, did not influence the subjects' breathing pattern.
D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide / Q000502:physiology; D005260:Female; D006801:Humans; D007216:Indoprofen / Q000494:pharmacology*; D007275:Injections, Intravenous; D008176:Lung Volume Measurements; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D010313:Partial Pressure; D010666:Phenylpropionates / Q000494:pharmacology*; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume; D013997:Time Factors
D010666:Phenylpropionates; D002245:Carbon Dioxide; D009020:Morphine; D007216:Indoprofen