Immunological evaluation in children with juvenile chronic arthritis treated with auranofin.
An immunological evaluation was performed before therapy and every four months during the first year of treatment with auranofin in 6 children with juvenile chronic arthritis. The immunological tests included: IgG, IgA, IgM, IgE and "natural" antibody serum levels, CH50 of the classical and alternative complement pathways, PWM-induced IgM production in vitro, and polymorphonuclear neutrophil functions. A reduction of the in vitro IgM synthesis and in the CH50 of the classical pathway of complement, and a normalization of impaired chemotaxis, occurred in patients who presented a clinically significant improvement during auranofin treatment.
D000917:Antibody Formation / Q000187:drug effects; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000276:immunology; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003167:Complement Activation / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology; D006046:Gold / Q000031:analogs & derivatives*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D013997:Time Factors
D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold