Induction of hepatic drug-metabolising enzymes following treatment of rats and mice with chlordimeform.
We investigated the effects of the formamidine insecticide chlordimeform upon the activities of various hepatic drug metabolising enzymes in rats and mice. Chlordimeform treatment induced several enzyme activities. However, the extent of induction depended upon the activity studied, the sex of the animal and the species selected. Microsomal cytochrome P-450 content was elevated in both male and female rats and mice. Ethoxycoumarin O-deethylase activity was induced in male and female rats but not in mice, whilst ethylmorphine N-demethylase activity was elevated in mice, but not in rats. Benzo(a)pyrene hydroxylase activity was increased in female rats and mice, but not in males. UDP-glucuronyl transferase, glutathione S-transferase and microsomal epoxide hydrolase were induced in a dose-dependent manner in male rats, and female rats and mice, but not in male mice.
D000578:Amidines / Q000633:toxicity*; D000818:Animals; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis; D002742:Chlorphenamidine / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D014453:Glucuronosyltransferase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D000578:Amidines; D003577:Cytochrome P-450 Enzyme System; D001579:Benzopyrene Hydroxylase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D002742:Chlorphenamidine