Protection of germinal epithelium with luteinizing hormone-releasing hormone analogue.
A dog model for chemotherapy and radiation-induced testicular damage was created to study the protective potential of superactive analogue of luteinizing hormone-releasing hormone, buserelin. Buserelin appeared to offer protection of the canine germinal epithelium against cyclophosphamide, cisplatinum and radiation. Clinical trials with buserelin in patients of reproductive age undergoing treatment for cancer should be encouraged.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002064:Buserelin / Q000494:pharmacology / Q000627:therapeutic use*; D002945:Cisplatin / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004285:Dogs; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011878:Radiotherapy / Q000009:adverse effects; D013733:Testicular Diseases / Q000517:prevention & control*; D013737:Testis / Q000187:drug effects* / Q000528:radiation effects
D000970:Antineoplastic Agents; D011837:Radiation-Protective Agents; D003520:Cyclophosphamide; D002064:Buserelin; D002945:Cisplatin