In vivo distribution and activity of aphidicolin on dividing and quiescent cells.
In view of a possible use of aphidicolin, an inhibitor of DNA polymerases (including viral DNA polymerases), to control excessive cell proliferation we have investigated: the effect of the drug on the growth of several human neoplastic cells; the activity of synthetic analogs aimed at relating the structural feature of aphidicolin to cytotoxicity; the in vivo fate and distribution of aphidicolin in different fluids, organs and tissues of mice following parenteral and/or peroral administration.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016590:Aphidicolin; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004257:DNA Polymerase II / Q000037:antagonists & inhibitors*; D004261:DNA Replication / Q000187:drug effects; D004224:Diterpenes / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000473:pathology; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D004224:Diterpenes; D006680:HLA Antigens; D016590:Aphidicolin; D004257:DNA Polymerase II