title: Pulmonary antioxidant defense mechanisms.
abstract: Intrinsic enzymatic and non-enzymatic pulmonary antioxidant defense mechanisms undoubtedly protect the lung against oxidant-mediated environmental stresses and diseases. In addition, new ways of augmenting pulmonary antioxidant defenses are being developed which can be used to bolster disease-overwhelmed intrinsic lung defense mechanisms. Improved understanding of antioxidant defense mechanisms will increase our knowledge of the causes and suggest rational approaches for treating oxidant-induced lung injury.
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008168:Lung / Q000502:physiology*; D008322:Mammals; D008954:Models, Biological; D009249:NADP / Q000378:metabolism; D011092:Polyethylene Glycols; D013482:Superoxide Dismutase / Q000378:metabolism; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D004041:Dietary Fats; D004044:Dietary Proteins; D008054:Lipid Peroxides; D014810:Vitamin E; D011092:Polyethylene Glycols; D009249:NADP; C038983:1,3-dimethylthiourea; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D013890:Thiourea; D000111:Acetylcysteine; D004121:Dimethyl Sulfoxide