The effect of allopurinol ribonucleoside and formycin B on Trypanosoma cruzi infections in mice.
The anti-Trypanosoma cruzi effect of allopurinol ribonucleoside and formycin B was examined against infections of the sensitive Y and Peru strains in inbred mice, strain DBA/1. Allopurinol ribonucleoside given in the drinking water at doses calculated to be 239, 511 and 929 mg/kg/day for 28 days, prevented the death of the mice but did not eradicate the infection. Formycin B given orally at 100 and 10 mg/kg/day X 5 days, showed a similar effect.
D000493:Allopurinol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy*; D005573:Formycins / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D012263:Ribonucleosides / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*
D000903:Antibiotics, Antineoplastic; D005573:Formycins; D012263:Ribonucleosides; D014344:Trypanocidal Agents; C034561:formycin B; D000493:Allopurinol; C021958:allopurinol riboside