Peroxisome proliferators show tumor-promoting but no direct transforming activity in vitro.
The chemically unrelated hypolipidemic drugs, tiadenol, niadenate, and clofibrate have been tested for carcinogenic and tumor-promoting potential in the C3H/10TI/2 C18 cell test system. None of these chemicals were carcinogenic, while both niadenate and clofibrate were active tumor promoters at micromolar concentrations. All 3 drugs induced the differentiation of C3H/10T1/2 C18 cells to adipocytes. This latter finding confirms previously observed effects of the tumor promoter TPA.
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002994:Clofibrate / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005233:Fatty Alcohols / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000633:toxicity*; D051379:Mice; D008830:Microbodies / Q000187:drug effects*; D009539:Nicotinic Acids / Q000633:toxicity; D013755:Tetradecanoylphorbol Acetate
D002273:Carcinogens; D005233:Fatty Alcohols; D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; C004568:tiadenol; C036558:niadenate; D002994:Clofibrate; D013755:Tetradecanoylphorbol Acetate