title: [The regulation of bone remodeling].
abstract: The adult skeleton is subject to a remodeling process which must be tightly regulated to keep bone mass constant. Bone resorption and bone formation are coupled. After a brief review of the cellular mechanisms of bone remodeling, its regulation is discussed. Bone resorption is modulated by parathyroid hormone, 1,25-dihydroxyvitamin D and other hormones. Locally, agents such as prostaglandins and factors from the immune system are important. Bone formation is stimulated by insulin and somatomedin C (= insulin like growth factor 1) which mediates the effect of growth hormone. Other hormones and local factors also play a role.
mesh_terms: D001846:Bone Development; D001862:Bone Resorption; D002116:Calcitonin / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010011:Osteocytes / Q000502:physiology; D010281:Parathyroid Hormone / Q000378:metabolism
chemical_list: D004100:Dihydroxycholecalciferols; D006133:Growth Substances; D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium
vernacular_title: Die Regulation des Knochenumbaus.