[Comparative evaluation of the hormonal changes in alimentaro-constitutional and hypothalamic obesity].
A study was made of change in hormone secretion in 243 patients with alimentary-constitutional and hypothalamic obesity. Activation of the somatostatin mechanism, a decrease in somatotropic and thyrotropic function of the hypophysis, an increment of corticotropin, beta-lipotropin and vasopressin levels in the blood, disturbance of circadian fluctuations of hormone secretion, an increase in insulin and C-peptide secretion, a decrease in glucagon secretion and triiodothyronine and cortisol levels in the blood, activation of the renin-aldosterone system and cortisol secretion rate were equally expressed both in alimentary-constitutional and primary hypothalamic obesity. The central mechanisms of the regulation of endocrine functions were incorporated in a pathological process even in alimentary-constitutional obesity. Disorders of the hypothalamic regulation lay in the basis of both types of obesity.
D000302:Adrenal Cortex / Q000378:metabolism; D001824:Body Constitution; D002940:Circadian Rhythm; D006728:Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D009765:Obesity / Q000097:blood*; D010179:Pancreas / Q000378:metabolism; D011863:Radioimmunoassay; D013961:Thyroid Gland / Q000378:metabolism
D006728:Hormones
Sravnitel'naia otsenka gormonal'nykh izmeneniĭ pri alimentarno-konstitutsional'nom i gipotalamicheskom ozhirenii.