title: Immunological evaluation in children with juvenile chronic arthritis treated with auranofin.
abstract: An immunological evaluation was performed before therapy and every four months during the first year of treatment with auranofin in 6 children with juvenile chronic arthritis. The immunological tests included: IgG, IgA, IgM, IgE and "natural" antibody serum levels, CH50 of the classical and alternative complement pathways, PWM-induced IgM production in vitro, and polymorphonuclear neutrophil functions. A reduction of the in vitro IgM synthesis and in the CH50 of the classical pathway of complement, and a normalization of impaired chemotaxis, occurred in patients who presented a clinically significant improvement during auranofin treatment.
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D001171:Arthritis, Juvenile / Q000188:drug therapy* / Q000276:immunology; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003167:Complement Activation / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D004912:Erythrocytes / Q000276:immunology; D006046:Gold / Q000031:analogs & derivatives*; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D013997:Time Factors
chemical_list: D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold