Plasma apolipoprotein pattern in fish-eye disease examined by high-resolution two-dimensional electrophoresis.
We compared the plasma protein patterns of the two living patients suffering from fish-eye disease with those of appropriate controls, using high-resolution two-dimensional electrophoresis. Quantitative abnormalities were detected in plasma polypeptides corresponding to the isoforms of apolipoproteins A-I and A-II. The disease was characterized by normal concentrations of proapo A-I but dramatically subnormal concentrations of the other apo A-I isoforms and apo A-II. No significant difference was detected in the concentrations of other plasma proteins. These findings are discussed in relation to other apolipoprotein disorders.
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001053:Apolipoproteins / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D005128:Eye Diseases / Q000097:blood* / Q000235:genetics; D006801:Humans; D007009:Hypolipoproteinemias / Q000097:blood* / Q000235:genetics; D007525:Isoelectric Focusing; D010455:Peptides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001053:Apolipoproteins; D001054:Apolipoproteins A; D010455:Peptides