Concentrations of metallothionein and metals in malignant and non-malignant tissues in human liver.
Concentration of metallothionein in the malignant and non-malignant tissues of the human liver was determined by the Cd-hem method. The concentration of metallothionein was high in the non-malignant tissue (471 +/- 306 micrograms/g). Metallothionein in the non-malignant tissue was mainly Zn-thionein and metallothionein-bound Zn was a major chemical form of Zn in the non-malignant tissue. The concentration of metallothionein in the malignant tissue was 75.6 +/- 79.6 micrograms/g, and significantly lower than that in the nonmalignant tissue. A strong, positive relationship was observed between the Zn and metallothionein concentrations, and the regression equation was MT (microgram/g) = -94.7 + 11.9 Zn (micrograms/g).
D000328:Adult; D002104:Cadmium / Q000032:analysis; D002850:Chromatography, Gel; D003300:Copper / Q000032:analysis; D006801:Humans; D008099:Liver / Q000032:analysis*; D008113:Liver Neoplasms / Q000032:analysis*; D008668:Metallothionein / Q000032:analysis* / Q000502:physiology; D015032:Zinc / Q000032:analysis / Q000502:physiology
D002104:Cadmium; D003300:Copper; D008668:Metallothionein; D015032:Zinc