Local cerebral glucose utilization in Long-Evans and Brattleboro rats during acute dehydration.
The quantitative autoradiographic deoxyglucose method was used to study the effects of acute dehydration on local cerebral glucose utilization in Long-Evans and homozygous Brattleboro rats. Water-sated Brattleboro rats had high rates of glucose utilization in the subfornical organ, habenular complex, septal triangular nucleus and pituitary neural lobe. Deprivation of water for 16-18 h enhanced glucose utilization in these structures, more intensely in the Brattleboro rats, and activated others, particularly those connected to the subfornical organ. In Long-Evans rats, water deprivation increased metabolic activity in the subfornical organ, in several structures with which it is connected, and in other brain regions putatively involved in maintaining fluid balance.
D000208:Acute Disease; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D003681:Dehydration / Q000378:metabolism*; D004027:Diencephalon / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D012686:Septal Nuclei / Q000378:metabolism; D013356:Subfornical Organ / Q000378:metabolism
D005947:Glucose