title: The disinfection of silicone-foam dressings.
abstract: The efficiency of four commonly used antiseptics, chlorhexidine, povidone-iodine, cetrimide and sodium hypochlorite was compared in the disinfection of silicone-foam dressing used in the management of open granulating wounds. An in vitro model was first used to determine the minimum effective concentration of each antiseptic in killing a standard culture of Pseudomonas. The appropriate concentrations were then compared in comparative studies of clinical wounds. Chlorhexidine proved to be the most effective antiseptic, povidone-iodine and cetrimide were moderately successful, but sodium hypochlorite gave poor results. A subsidiary study looked at the problem of wound irritation by carry-over of the antiseptic. A rinse of the dressing after disinfection prevented irritation by chlorhexidine without compromising its antibacterial effect, but this procedure sometimes failed to prevent irritation when using the other antiseptic agents. It is concluded that chlorhexidine is the preferred cleansing agent in the management of silicone-foam dressings on both grounds of bacteriological efficiency and lack of wound irritation. It should be noted that Hibitane concentrate used in this work contains non-ionic detergent and a stabilizing agent. Pure preparations of chlorhexidine may not behave similarly.
mesh_terms: D000891:Anti-Infective Agents, Local; D001458:Bandages; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D004203:Disinfection; D006801:Humans; D008954:Models, Biological; D011206:Povidone-Iodine / Q000627:therapeutic use; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012828:Silicones; D012973:Sodium Hypochlorite / Q000627:therapeutic use; D013242:Sterilization; D014947:Wounds and Injuries / Q000628:therapy
chemical_list: D000891:Anti-Infective Agents, Local; D002593:Cetrimonium Compounds; D012828:Silicones; D011206:Povidone-Iodine; D012973:Sodium Hypochlorite; D002710:Chlorhexidine; D000077286:Cetrimonium