The Ro 15-1788 cue: evidence for benzodiazepine agonist and inverse agonist properties.
Rats discriminating Ro 15-1788 (10 mg/kg, i.p.) from vehicle completely generalized this cue to typical benzodiazepines, and partially generalized it to barbiturates, pentylenetetrazol, CGS 8216, beta-CCM and PK 8165. CL 218872, Ro 5-4864, phenytoine, progabide, propranolol, yohimbine and various CNS stimulants predominantly induced vehicle-appropriate responding. Chlordiazepoxide, pentobarbital, CL 218 872, PK 8165, pentylenetetrazol, CGS 8216 and beta-CCM failed to block the Ro 15-1788 cue. Generalization to both anxiolytics/anticonvulsants and anxiogenics/(pro) convulsants suggests that Ro 15-1788 has benzodiazepine agonist and inverse agonist properties.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D004192:Discrimination, Psychological; D005442:Flumazenil; D008297:Male; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D001463:Barbiturates; D001570:Benzodiazepinones; D003292:Convulsants; D011724:Pyridazines; D001569:Benzodiazepines; D005442:Flumazenil; C021604:CL 218872