No evidence for an autoregulatory mechanism for the proestrous afternoon surge of prolactin secretion in rats.
The temporal effects of intracerebroventricular (icv) infusion of prolactin (PRL) on endogenous PRL secretion was investigated in intact, freely moving, cycling rats. An icv infusion of 10 ng or 100 ng rat-PRL/min from 13.00 to 17.00 h during the proestrous afternoon did not affect endogenous PRL secretion; infusion from 09.00 to 13.00 h showed a tendency to delay the time of onset of the PRL proestrous afternoon surge. The results do not indicate the involvement of an autoregulatory mechanism in the expression or the termination of the proestrous afternoon surge of PRL secretion.
D000818:Animals; D004971:Estrus; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D008433:Mathematics; D011359:Proestrus; D011388:Prolactin / Q000008:administration & dosage / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011388:Prolactin