title: Combination therapy for psoriasis with methotrexate and etretinate.
abstract: Two young male patients with severe erythrodermic psoriasis and pustular episodes have both been successfully treated with a combination of methotrexate and etretinate for a period of 21/2 years. On this regimen, relative clearing of the psoriatic lesions has been achieved with no significant side effects. Neither patient has developed evidence of hepatotoxicity. The safety of and indications for combination therapy with methotrexate and etretinate are discussed, and the recent reports in the literature of experience with this combination regimen are considered.
mesh_terms: D000328:Adult; D002280:Basal Cell Carcinoma / Q000209:etiology; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011701:PUVA Therapy / Q000009:adverse effects; D011565:Psoriasis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000209:etiology
chemical_list: D005050:Etretinate; D008727:Methotrexate