title: Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti: potent anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide.
abstract: The anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide (emimycin riboside), against five species of chicken Eimeria was tested individually in battery experiments. With 16 ppm of the compound in feed, marked anticoccidial activity was obtained against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti. The last named species was more drug-sensitive than the others--dietary levels of at least 8 ppm of the drug exhibited good protection and eliminated practically all clinical signs. The battery tests with delayed and restricted medications showed that emimycin riboside affected the development of parasites in first and second generation schizogony of the life cycle of E. tenella.
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004539:Eimeria / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D012263:Ribonucleosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013045:Species Specificity
chemical_list: D003049:Coccidiostats; D012263:Ribonucleosides; C047873:emimycin riboside