title: Heterogeneity of growth hormone in the nocturnal serum of children.
abstract: The nocturnal serum of 13 nongrowth hormone deficient, hyposomatomedinemic short children and of 12 normal children of average height was analyzed by both polyclonal and biclonal radioimmunoassays. The biclonal/polyclonal ratio for immunochemical grade human growth hormone was 1.0, but for the nocturnal sera in both groups, this ratio was significantly less than 1.0 (range 0.5-1.2, average 0.7-0.8). The ratio did not differ significantly between the two groups of children.
mesh_terms: D000293:Adolescent; D001667:Binding, Competitive; D002648:Child; D002850:Chromatography, Gel; D002940:Circadian Rhythm; D003429:Cross Reactions; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006130:Growth Disorders / Q000097:blood*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010928:Placental Lactogen / Q000097:blood; D011863:Radioimmunoassay; D012890:Sleep; D013002:Somatomedins / Q000172:deficiency; D013972:Thyrotropin / Q000097:blood
chemical_list: D013002:Somatomedins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D010928:Placental Lactogen