title: [Dependence of the duration of inhibition of the hypophyseo-adrenal cortex system on the dose of administered hydrocortisone in rats].
abstract: The effect of various doses of hydrocortisone on the functioning of the hypophyseal-adrenocortical system was studied in experiments on rats. The administration of increasing amounts of hydrocortisone (at a single dose of 100 micrograms 300 micrograms/100 g twice a day for 2 days) resulted in a prolonged period of the inhibition of basal and stress factor-induced corticosterone secretion. The stress reaction of the hypophyseal-adrenocortical system changed under the influence of hydrocortisone to a lesser degree than adrenal hormone basal secretion. An increase in the amount of administered hydrocortisone demonstrated a gradual transition from physiological inhibition of the hypophyseal-adrenocortical system to pathologically prolonged inhibition similar to that known in clinical practice.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005246:Feedback; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone
vernacular_title: Zavisimost' dlitel'nosti tormozheniia gipofizarno-adrenokortikal'noĭ sistemy ot dozy vvedennogo gidrokortizona u krys.