title: Fenbendazole in equids: further controlled tests with emphasis on activity of multiple doses against naturally occurring infections of migratory large strongyles.
abstract: Two controlled tests (experiments D and E) were done to evaluate a fenbendazole (FBZ) paste dosage regimen (10 mg/kg once a day for 5 days) for activity against naturally occurring infections of migrating Strongylus vulgaris and S edentatus in the mesenteric arteries and ventral abdominal wall, respectively. Data were also obtained on other internal parasites of the gastrointestinal tract and eyes in experiment E. Eight pony yearlings were used in experiment D (4 treated and 4 nontreated) and 6 horse weanlings were used in experiment E (3 treated and 3 nontreated). Intervals, expressed as days between treatment and necropsy of animals, were 42 (n = 1) or 52 (n = 7) for experiment D and 52 or 53 for experiment E. Animals were on pasture during all or a portion of post-treatment intervals of both experiments. Efficacious killing of retroperitoneal forms of S edentatus in the ventral abdominal wall was observed in both experiments. The average numbers of live 4th-stage forms in equids were 0.0 (treated) and 2.25 (nontreated) for experiment D and 2.0 (treated) and 1.7 (nontreated) for experiment E. The average numbers of 5th-stage S edentatus were 0.5 (treated) and 4.0 (nontreated) for experiment D and 1.3 (treated) and 23.3 (nontreated) for experiment E. Fragments of dead specimens of S edentatus were also found in nodules in treated animals in both experiments, but not in nontreated animals. Consistency of the retroperitoneal lesions provided additional evidence of the killing action of the FBZ treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007814:Larva; D008297:Male; D009348:Nematoda / Q000187:drug effects / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D013045:Species Specificity; D013320:Strongyloidea / Q000254:growth & development*; D013323:Strongylus / Q000187:drug effects / Q000254:growth & development*
chemical_list: D001562:Benzimidazoles; D005273:Fenbendazole