title: Cost analysis of antibiotics in the management of perforated or gangrenous appendicitis.
abstract: Costs associated with treating patients for gangrenous or perforated appendicitis were compared. Patients received single agent therapy with cefoperazone or cefamandole or combination antibiotics consisting of clindamycin and serum level-adjusted gentamicin. Forty-eight patients received cefamandole, 47 received cefoperazone, and 52 received combination clindamycin and gentamicin. Costs to the pharmacy for drugs were greater for the combination therapy; however, the higher failure rate associated with the cephalosporins created greater expenses for the single agent therapy than for combination therapy.
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001064:Appendicitis / Q000188:drug therapy / Q000191:economics* / Q000473:pathology; D002435:Cefamandole / Q000627:therapeutic use; D002438:Cefoperazone / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D003365:Costs and Cost Analysis; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005734:Gangrene; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D007416:Intestinal Perforation / Q000188:drug therapy / Q000191:economics*; D008875:Middle Aged; D012189:Retrospective Studies; D012422:Rupture, Spontaneous
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin; D002435:Cefamandole; D002438:Cefoperazone