Vitamin E consumption by human blood platelets activated by latex particles.
Human blood platelet activation elicited by latex particles is associated to a 30% decrease in the cellular content of vitamin E. The vitamin E consumption is inhibited by the addition of catalase (500 U/ml) and azide (1 mM), but it is not affected by potassium cyanide (1 mM). It may be proposed that the challenge of platelets with particulate stimuli causes generation of oxygen reduction products, which leads to vitamin E depletion.
D001386:Azides / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D002374:Catalase / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D007840:Latex; D008315:Malondialdehyde / Q000096:biosynthesis; D008863:Microspheres; D010100:Oxygen / Q000378:metabolism; D019810:Sodium Azide; D013929:Thromboxane B2 / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D001386:Azides; D005609:Free Radicals; D007840:Latex; D014810:Vitamin E; D008315:Malondialdehyde; D013929:Thromboxane B2; D019810:Sodium Azide; D002374:Catalase; D010100:Oxygen