title: [Acute drug-induced pancreatitis].
abstract: 93 publications concerning drug-induced pancreatitis are reviewed. A confirmed causal relationship between drug and acute pancreatitis so far exists only for 8 compounds: azathioprine, chlorothiazide, furosemide, sulfonamides, tetracycline, estrogens, valproic acid and L-asparaginase. There is less convincing, but still suggestive, evidence for a causal relationship with 5 other drugs, namely: corticosteroids, chlorthalidone, ethacrynic acid, phenformin and iatrogenic hypercalcemia. Due to inadequate or contradictory evidence, the link between a number of additional drugs and acute pancreatitis is considered possible, conditional or doubtful. Finally, the scant literature concerning the pathogenesis and histological lesions of drug-induced pancreatitis is briefly reviewed.
mesh_terms: D000208:Acute Disease; D001215:Asparaginase / Q000009:adverse effects; D001379:Azathioprine / Q000009:adverse effects; D002740:Chlorothiazide / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004967:Estrogens / Q000009:adverse effects; D005665:Furosemide / Q000009:adverse effects; D006801:Humans; D010195:Pancreatitis / Q000139:chemically induced*; D013449:Sulfonamides / Q000009:adverse effects; D013752:Tetracycline / Q000009:adverse effects; D014635:Valproic Acid / Q000009:adverse effects
chemical_list: D004967:Estrogens; D013449:Sulfonamides; D014635:Valproic Acid; D002740:Chlorothiazide; D005665:Furosemide; D001215:Asparaginase; D013752:Tetracycline; D001379:Azathioprine
vernacular_title: Medikamentös induzierte akute Pankreatitis.