title: [Toxicologic studies with thymostimulin].
abstract: Thymostimulin (Tp-1 Serono) was tested toxicological in rats and monkeys during 6 weeks of repeated administration. Corresponding to the therapeutic use intended in man the substance was given to rats and monkeys intramuscularly in dosages of 10 or 100 mg/kg b.w. and due to technical reasons subcutaneously in a dosage of 1000 mg/kg b.w. No substance-related effects, either systemic or local, were observed in the monkeys. After treatment with the high dose level (1000 mg/kg b.w. s.c.) the rats exhibited inflammatory changes in the region of the injection sites.
mesh_terms: D000818:Animals; D005260:Female; D000882:Haplorhini; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013949:Thymus Extracts / Q000633:toxicity*
chemical_list: D013949:Thymus Extracts; C031407:thymostimulin
vernacular_title: Toxikologische Untersuchungen mit Thymostimulin.