Virilization during pregnancy due to bilateral hyperthecosis. A case report.
A case of recurrent maternal virilization associated with bilateral hyperthecosis of the ovary during two pregnancies is described. In the first pregnancy, serum testosterone increased to the level of 12.5 nmol/l and in the second pregnancy to 35 nmol/l and after delivery to 66 nmol/l.5 months after the second birth the testosterone level was 2.7 nmol/l and virilization had spontaneously regressed. Puerperal stimulation tests with human menopausal or with human chorionic gonadotropin did not increase ovarian androgen production. Female babies were not virilized.
D000328:Adult; D000735:Androstenedione / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007231:Infant, Newborn; D010049:Ovarian Diseases / Q000150:complications* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D013739:Testosterone / Q000097:blood; D013799:Theca Cells / Q000473:pathology; D014770:Virilism / Q000209:etiology*
D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol