Neonatal behaviour disturbances in infants of epileptic women treated during pregnancy.
Infants exposed in utero to antiepileptic drugs showed significantly more behaviour disturbances such as sedation (p less than 0.05) and hyperexcitability (p less than 0.01) than infants of a control group. The presence of these clinical symptoms and the time of their appearance did not seem to be dependent on the type of maternal medication, nor on the drug serum concentration in cord blood nor on the rate of drug disappearance from the infant's plasma.
D017109:Akathisia, Drug-Induced; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002653:Child Behavior Disorders / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced
D000927:Anticonvulsants