Effect of high intensity impulse noise on the vascular system of the chinchilla cochlea.
Changes in the vasculature of the chinchilla cochlea were quantitatively assessed 45 days after impulse noise exposure of either 155- or 160-dB peak sound pressure level. The condition of the vessels in the lateral wall and spiral lamina of each cochlea was evaluated in terms of 20 morphological parameters. Multivariate statistical analysis identified the parameters that were significantly affected by the noise exposure. Evaluation of these significant parameters indicated a net reduction in blood flow to the cochlea. All of the noise-exposed cochleas showed vascular changes when compared to controls, and the magnitude of these changes was related to the amount of hair cell loss. The vascular changes are presumed to be permanent.
D000818:Animals; D002682:Chinchilla; D003051:Cochlea / Q000098:blood supply* / Q000648:ultrastructure; D004906:Erythrocyte Count; D006198:Hair Cells, Auditory / Q000648:ultrastructure; D007958:Leukocyte Count; D009622:Noise / Q000009:adverse effects*; D013316:Stria Vascularis / Q000098:blood supply / Q000648:ultrastructure