Enhancement of phenol-induced tremor caused by central monoamine depletion.
The effects of monoamine depletors and monoamine denervators on phenol-induced tremor were studied in mice. The tremor induced by phenol was enhanced by pretreatment with reserpine or tetrabenazine, but not with syrosingopine. However, alpha-methyl-p-tyrosine, p-chlorophenylalanine or 6-hydroxydopamine did not affect the tremor. These results suggest that the depletion of central monoamines as a whole contribute to the enhancement of the tremor induced by phenol.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D019800:Phenol; D010636:Phenols / Q000494:pharmacology*; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced*
D008996:Monoamine Oxidase Inhibitors; D010636:Phenols; D019800:Phenol