Comparative structural aspects of cation binding to phosphatidylserine bilayers.
X-ray diffraction data recorded for monovalent and divalent cation complexes of a series of phosphatidylserines (PS) varying in chain length reveal a simple structural pattern. Only two bilayer structural types differing in hydrocarbon chain tilt but with similar polar group conformations are observed for (i) anhydrous acidic PS, (ii) anhydrous K+-PS, and (iii) Li+, Mg2+, Ca2+, Sr2+, Ba2+, and Pr3+ complexes of 'hydrated' PS. The X-ray diffraction data suggest that PS becomes dehydrated on complexing with Li+, Mg2+, Ca2+, and other divalent cations and adopts either the chain untilted (form I) or tilted (form II) bilayer structure.
D001464:Barium / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002412:Cations / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003460:Crystallization; D008051:Lipid Bilayers / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008968:Molecular Conformation; D010718:Phosphatidylserines / Q000378:metabolism*; D013324:Strontium / Q000378:metabolism; D014961:X-Ray Diffraction
D002412:Cations; D008051:Lipid Bilayers; D010718:Phosphatidylserines; D001464:Barium; D008094:Lithium; D008274:Magnesium; D002118:Calcium; D013324:Strontium