Bioavailability of D-penicillamine in a patient with gastrointestinal progressive systemic sclerosis.
D-penicillamine pharmacokinetics were studied in a patient with gastrointestinal progressive systemic sclerosis possibly complicated by malabsorption. D-penicillamine bioavailability was examined after oral, duodenal, intravenous and rectal administration. No D-penicillamine was detectable in plasma after administration to the gastrointestinal tract. The pharmacokinetics after intravenous administration agreed closely with the corresponding situation in healthy volunteers.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004733:Enema; D005223:Fats / Q000032:analysis; D005243:Feces / Q000032:analysis; D005767:Gastrointestinal Diseases / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010396:Penicillamine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012007:Rectum; D012595:Scleroderma, Systemic / Q000378:metabolism*
D005223:Fats; D010396:Penicillamine