The influence of maternal protein deprivation on the developmental pattern of serum immunoreactive insulin-like growth factor 1 (IGF-1) levels.
The influence of maternal protein deprivation on body and brain growth and on serum immunoreactive insulin-like growth factor I (IGF-I) levels was examined in rats during development. The offspring of protein-deprived mothers were significantly growth-retarded postnatally and showed an altered developmental pattern of serum immunoreactive IGF-I levels. In contrast to control animals, between days 5 and 20 postnatally, a significant elevation in serum immunoreactive IGF-I levels which peaked at day 15 was found. However, in adult growth-retarded rats a significant reduction in serum immunoreactive IGF-I levels was found. These findings suggested the preweaning period to be critical for the development of the mature somatomedin system.
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000254:growth & development*; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000097:blood*; D008431:Maternal-Fetal Exchange; D009929:Organ Size; D011247:Pregnancy; D011248:Pregnancy Complications; D011488:Protein Deficiency; D051381:Rats; D011919:Rats, Inbred Strains; D013002:Somatomedins / Q000097:blood*
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I