Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats.
The administration of sublethal doses of Escherichia coli O111:B4 endotoxin to starved rats results in significant increases in plasma ammonia, free fatty acids, and serum lactate compared with starved controls. These metabolic alterations are associated with Reye syndrome-like histological findings of hepatic microvesicular fatty accumulation and hepatic ultrastructural evidence of mitochondrial pleomorphism with matrix disruption. This sublethal endotoxin model may help elucidate the relationship between the hepatic mitochondrial injury, characteristic metabolic impairment, and encephalopathy seen in patients with Reye syndrome.
D000410:Alanine Transaminase / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007773:Lactates / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D008930:Mitochondria, Liver / Q000648:ultrastructure*; D008933:Mitochondrial Swelling; D051381:Rats; D011919:Rats, Inbred Strains; D012202:Reye Syndrome / Q000097:blood / Q000382:microbiology* / Q000473:pathology
D001786:Blood Glucose; D004731:Endotoxins; D005230:Fatty Acids, Nonesterified; D007773:Lactates; C044101:endotoxin, Escherichia coli; D000641:Ammonia; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase