The effect of tetrachlorohydroquinone on hexachlorobenzene-induced porphyria in Japanese quail.
Female Japanese quail received either hexachlorobenzene (HCB, 100 mg/kg . d) or tetrachlorohydroquinone (TCHQ, 175 mg/kg . d) for 10 d as a primary treatment. Following this, a secondary treatment of HCB (100 mg/kg . d) or TCHQ (175 mg/kg . d), alone or in combination, was administered for 1, 5, 10 or 15 d. The primary HCB treatment caused elevated delta-aminolevulinic acid synthetase (ALA-S) activities and small increases in porphyrin concentrations. Subsequent treatment of these birds with lactose resulted in no further increases in porphyrins or ALA-S. TCHQ treatment caused increases in porphyrins similar to those seen with continued HCB treatment. Apparently, despite the fact that TCHQ alone had no affect on ALA-S or porphyrin levels, this compound is able, in the presence of elevated ALA levels to cause porphyria. A combination of HCB and TCHQ administered to HCB-pretreated animals caused a more severe porphyria than did follow-up treatment with either HCB or TCHQ alone.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D002722:Chlorobenzenes / Q000633:toxicity*; D003370:Coturnix; D004347:Drug Interactions; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism / Q000633:toxicity*; D006873:Hydroquinones / Q000633:toxicity*; D007785:Lactose / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008107:Liver Diseases / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000032:analysis*
D002722:Chlorobenzenes; D006873:Hydroquinones; D011166:Porphyrins; D006581:Hexachlorobenzene; C044578:2,3,5,6-tetrachlorohydroquinone; D000624:5-Aminolevulinate Synthetase; D007785:Lactose