[Effect of brain antibodies on the lipid peroxidation process in the brain].
The authors studies the effects of blood serum and IgG fraction from dogs immunized with brain and blood sera from patients with multiple sclerosis and schizophrenia on lipid peroxidation in rat brain homogenates. Measured the content of diene conjugates (DC) and malonic dialdehyde (MDA) in the rat brain after administering the IgG fraction. It was established that antioxidant activity of blood sera and IgG fraction from control animals and donors was significantly higher as compared to experimental. Administration of the IgG fraction brought about an increase in the content of DC and MDA in the brain of experimental animals. It is concluded that complement-dependent brain antibodies present in the blood serum of patients with schizophrenia and multiple sclerosis potentiate lipid peroxidation in the cerebral tissue and that the unsophisticated and informative method for antibody determination may be used in clinical practice.
D000818:Animals; D000906:Antibodies / Q000502:physiology*; D001921:Brain / Q000276:immunology* / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism; D004285:Dogs; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000502:physiology; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012559:Schizophrenia / Q000378:metabolism
D000906:Antibodies; D007074:Immunoglobulin G; D008054:Lipid Peroxides
Vliianie protivomozgovykh antitel na protsess perekisnogo okisleniia lipidov v mozge.