Modification of bone formation rate by growth hormone, melanocyte-stimulating hormone, and cortisone in the normal rat.
Bone growth and remodelling was studied in rats after injection of growth hormone, melanocyte-stimulating hormone (alpha-MSH), and cortisone daily for 20 days with tetracycline as intravital marker. An increase of both longitudinal and periosteal growth with growth hormone was found. A decrease of both was found after a high cortisone dose. Lower cortisone doses seem to have stimulated periosteal growth. No effect of alpha-MSH was found.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D003348:Cortisone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005269:Femur / Q000254:growth & development; D006128:Growth; D013006:Growth Hormone / Q000494:pharmacology*; D006321:Heart / Q000033:anatomy & histology; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010521:Periosteum / Q000502:physiology; D051381:Rats / Q000254:growth & development*; D011919:Rats, Inbred Strains
D013006:Growth Hormone; D009074:Melanocyte-Stimulating Hormones; D003348:Cortisone