Assessment of the hot-plate antinociceptive test in mice. A new method for the statistical treatment of graded data.
The use of graded data from hot-plate antinociceptive tests is complicated by the problem of how to treat responses that are greater than the cut-off time. This paper describes a statistical procedure for analysis of antinociceptive data that circumvents this problem. The method is based upon the likelihood function and the data is assumed to follow a Weibull distribution. The technique can be implemented with the use of a computer and provides a more comprehensive assessment of antinociceptive data.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006358:Hot Temperature; D051379:Mice; D009294:Narcotics / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D012107:Research Design; D013223:Statistics as Topic
D000700:Analgesics; D009294:Narcotics