Evidence of abnormality of lymphocyte uroporphyrinogen synthase in family members of patients with lymphoproliferative diseases.
Patients with active lymphoproliferative diseases (LPD) were shown to have high activity of lymphocyte uroporphyrinogen synthase (L-UROS), the enzyme which converts porphobilinogen to uroporphyrinogen. The mean L-UROS activity of 64 first-degree relatives of patients with LPD was significantly higher than that of a control group and 45% of these relatives had pathological values of L-UROS. L-UROS activity was also determined in the spouses of 2 patients and was pathologically elevated in both. The pattern of pathological values among family members may indicate the presence of a communicable agent.
D000328:Adult; D000368:Aged; D000642:Ammonia-Lyases / Q000097:blood*; D005260:Female; D006689:Hodgkin Disease / Q000201:enzymology / Q000235:genetics; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood*; D011163:Hydroxymethylbilane Synthase / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000235:genetics; D008214:Lymphocytes / Q000201:enzymology*; D008223:Lymphoma / Q000201:enzymology / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000201:enzymology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014576:Uroporphyrinogen III Synthetase / Q000097:blood*
D011163:Hydroxymethylbilane Synthase; D006836:Hydro-Lyases; D014576:Uroporphyrinogen III Synthetase; D000642:Ammonia-Lyases