Bactericidal effects of amoxycillin/clavulanic acid and ticarcillin/clavulanic acid in in-vitro kinetic models.
The bactericidal effects of amoxycillin and ticarcillin in the presence of clavulanic acid against beta-lactamase-producing bacteria were investigated in in-vitro kinetic models. Amoxycillin/clavulanic acid was rapidly bactericidal as a simulated intravenous 1.2 g bolus dose, against a strain of Klebsiella pneumoniae highly resistant to amoxycillin. Similarly, ticarcillin/clavulanic acid at concentrations similar to those achieved with a 30 min iv infusion of ticarcillin/clavulanic acid (5.0 g/200 mg) produced bactericidal effects against a ticarcillin-resistant strain of Pseudomonas aeruginosa. Addition of gentamicin to the system resulted in a further enhancement of activity.
D000658:Amoxicillin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D004338:Drug Combinations; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010406:Penicillins / Q000008:administration & dosage*; D013982:Ticarcillin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology
D002969:Clavulanic Acids; D004338:Drug Combinations; D010406:Penicillins; D019818:Clavulanic Acid; D000658:Amoxicillin; D013982:Ticarcillin