An investigation of the functional role of the carboxylic groups of heparin. Affinity for antithrombin III and anti-Xa activity of selectively carboxyl esterified heparin.
D000990:Antithrombin III / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004951:Esterification; D005170:Factor X / Q000037:antagonists & inhibitors*; D015951:Factor Xa; D005965:Glucuronates; D020723:Glucuronic Acid; D006493:Heparin / Q000378:metabolism / Q000494:pharmacology*; D007067:Iduronic Acid; D013329:Structure-Activity Relationship; D013431:Sulfates; D014574:Uronic Acids
D005965:Glucuronates; D013431:Sulfates; D014574:Uronic Acids; D007067:Iduronic Acid; D020723:Glucuronic Acid; D000990:Antithrombin III; D005170:Factor X; D006493:Heparin; D015951:Factor Xa