Prenatal selection and fetal development disturbances occurring in carriers of G6PD deficiency.
The incidence of spontaneous abortions in women with glucose-6-phosphate dehydrogenase (G6PD) deficiency was studied. In 78 families where the wife was a heterozygous carrier of G6PD deficiency the percentage of unsuccessful pregnancies with spontaneous abortions occurring in the first trimester was higher (21.7%, calculated from 258 pregnancies) than in the control group (9.3%, calculated from 678 pregnancies.
D000022:Abortion, Spontaneous / Q000235:genetics*; D005260:Female; D005328:Fetal Viability; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D011247:Pregnancy; D012641:Selection, Genetic