title: Lymphangiosarcoma of the edematous thigh after radiation therapy for carcinoma of the vulva.
abstract: A 66-year-old patient was treated with external radiation therapy for an advanced carcinoma of the vulva. Seven years later, a lymphangiosarcoma developed in her edematous lower extremity. Lymphangiosarcomas have been reported to occur in postmastectomy patients; however, this is only the third case in a patient with a gynecologic primary malignancy. In anticipation of possible increased use of radiation therapy in vulvar carcinoma, gynecologists should be aware of this rare, highly aggressive neoplasm.
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D004487:Edema / Q000150:complications / Q000209:etiology*; D005260:Female; D006801:Humans; D008204:Lymphangiosarcoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D009378:Neoplasms, Multiple Primary; D009381:Neoplasms, Radiation-Induced; D011867:Radioisotope Teletherapy; D011878:Radiotherapy / Q000009:adverse effects*; D013848:Thigh; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014846:Vulvar Neoplasms / Q000532:radiotherapy*
chemical_list: D003037:Cobalt Radioisotopes