Effect of Zaditen on serum neutrophil chemotactic activity in exercise-induced asthma.
Zaditen has a partial blocking effect in exercise-induced asthma, but the mechanism of this effect is unknown. In our study we investigated the effect of Zaditen on one of the mediators released by mast cells. We measured the serum neutrophil chemotactic activity - by using a modified Boyden chamber assay - after 2 week's treatment with Zaditen or placebo. The airway parameters (SGaw) were recorded with a wholebody plethysmograph. Our studies on 10 patients show that Zaditen has a protective effect on the release of the neutrophil chemotactic factor during an exercise challenge test. A direct effect of Zaditen on the mast cell degranulation process is postulated.
D000328:Adult; D001249:Asthma / Q000097:blood / Q000517:prevention & control*; D001250:Asthma, Exercise-Induced / Q000517:prevention & control*; D002630:Chemotactic Factors / Q000097:blood*; D006801:Humans; D007665:Ketotifen / Q000627:therapeutic use*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011292:Premedication
D002630:Chemotactic Factors; D007665:Ketotifen