Preformulation studies in a drug development program for tablet formulations.
Recently developed techniques were applied in a preformulation program to select a compound and a suitable salt for use in a one-month toxicological test. The program showed that valuable information can be obtained prior to the choice of a compound as a candidate for a solid-dosage form. Information about the physical and mechanical properties of the chosen compound can be obtained with a limited amount of substance, i.e., surface color and hygroscopicity (1-2 g), dissolution rate and solubility (1-2 g), powder properties (1-2 g), and compaction properties (5-7 g).
D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003116:Color; D004339:Drug Compounding; D004355:Drug Stability; D010316:Particle Size; D011208:Powders; D012995:Solubility; D013607:Tablets
D011208:Powders; D013607:Tablets