[Dependence of the embryotoxic action of dioxidine and cyclophosphamide on the immunoreactivity of the maternal-fetal system in mice].
It has been shown that the embryotoxic action of cyclophosphamide and dioxydin (an antibacterial drug) was more pronounced upon syngeneic than upon reciprocal crossing of CBA and C57BL/6 mice. Preliminary (21 days before crossing intrauterine sensitization of C57BL/6 mice with syngeneic or allogeneic lymphocytes obtained from males' spleen led to the attenuation of the embryotoxic action of cyclophosphamide and dioxydin. During sensitization with allogeneic lymphocytes, the embryotoxic action was attenuated more appreciably. Extirpation of the paraaortal lymph nodes in female C57BL/6 mice performed 14-15 days before crossing potentiated the embryotoxic action of cyclophosphamide in the case of allogeneic crossing of females. Upon syngeneic crossing of females with the extirpated paraaortal lymph nodes the intensity of the embryotoxic action of cyclophosphamide remained unchanged. It is concluded that the immune status of the mother-embryo system can, under the definite conditions, determine the intensity of the embryotoxic action of xenobiotics on the mammals.
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D003433:Crosses, Genetic; D003520:Cyclophosphamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011810:Quinoxalines / Q000633:toxicity*; D013997:Time Factors
D000890:Anti-Infective Agents; D011810:Quinoxalines; C001077:dioxidine; D003520:Cyclophosphamide
Issledovanie zavisimosti émbriotokischeskogo deĭstviia dioksidina i tsiklofosfamida ot immunoreaktivnosti sistemy mat'-plod u mysheĭ.