Intubating conditions following pre-induction priming with alcuronium.
Three priming doses of alcuronium have been investigated and, using a logistic transformation technique, the priming dose required to produce adequate intubating conditions in 99% of patients at 60 seconds following the second dose of alcuronium has been deduced. This dose, 106.5 micrograms/kg is extremely high and may be unsafe if used, since 30% of our patients complained of side effects when given a priming dose of only 50 micrograms/kg.
D000328:Adult; D000443:Alcuronium / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D007568:Jaw / Q000502:physiology; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects; D013997:Time Factors; D014117:Toxiferine / Q000031:analogs & derivatives*; D014827:Vocal Cords / Q000502:physiology
D014117:Toxiferine; D000443:Alcuronium