Learned tolerance to ethanol in a spinal reflex separated from supraspinal control.
We have recently reported that ethanol-induced inhibition of the tail flick reflex in intact and spinal rats is diminished during an eight day period if the animals are tested daily under the influence of ethanol. Ethanol only, or testing before ethanol administration, is not followed by tolerance. In the present study we used the tail flick testing of spinal rats to investigate the effect on tolerance development of repetitively triggering the tail flick reflex during intoxication, and of just placing the intoxicated animals in the test apparatus. We also investigated if damage to the tail tissue, due to repetitive prolonged test exposure, would facilitate the reflex and thereby reduce the inhibitory effect of ethanol. The results indicated that triggering of the reflex in the presence of ethanol was necessary for the tolerance to develop. Facilitation of the tail flick reflex, due to damage of the tail tissue, was not revealed. Thus the tolerance observed seems to be caused by an adaption to ethanol learned by structures involved in the tail flick reflex.
D000818:Animals; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D013116:Spinal Cord / Q000502:physiology*
D000431:Ethanol