title: Psychophysiological evidence for cerebral laterality effects in a high-risk sample of students with subsyndromal bipolar depressive disorder.
abstract: The authors compared bilateral recordings of electrodermal activity and conjugate lateral eye movements in two groups (10 men and 10 women each) of college students: high-risk nonpatients with subsyndromal depression and normal control subjects. Like acutely depressed patients, the high-risk subjects showed smaller right- than left-hand skin conductance response amplitudes to neutral tones. This group also showed a bias toward left-tending conjugate lateral eye movements in response to various cognitive problems. Control subjects showed symmetrical responses on all electrodermal activity measures and question-specific conjugate lateral eye movements. These data are tentatively interpreted as reflecting right-hemisphere hyperexcitability in affective illness.
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D005133:Eye Movements; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D005712:Galvanic Skin Response; D006801:Humans; D008297:Male; D010555:Personality Inventory; D011340:Problem Solving / Q000502:physiology; D012306:Risk