title: Induction of chromosomal aberrations in the Syrian hamster by insecticides tested in vivo.
abstract: The insecticides demeton, dimetoat, dichlorovos, endosulfan, trichlorofon, carbaryl, lindane, methoxychlor, propoxur and malathion were examined for their ability to induce chromosomal aberrations in the bone marrow cells of the Syrian hamster (Mesocricetus auratus) treated in vivo. Mutagenicity of commercial preparations was examined at four doses: LD50; 1/2, 1/5 and 1/10 LD50. The positive control was an IP injection of cyclophosphamide to hamsters at a dose of 40 mg/kg body wt. Demeton, dichlorovos and endosulfan gave positive results. Malathion, dimethoate and the mixture of methoxychlor and propoxur were weakly clastogenic; at some doses these compounds induced statistically significant increases in the number of aberrations. Trichlorfon and the mixture of carbaryl and lindane were negative in this test.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D003520:Cyclophosphamide / Q000633:toxicity; D004006:Dichlorvos / Q000633:toxicity; D004117:Dimethoate / Q000633:toxicity; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008294:Malathion / Q000633:toxicity; D008647:Mesocricetus; D063086:Organothiophosphates / Q000633:toxicity; D014236:Trichlorfon / Q000633:toxicity
chemical_list: D007306:Insecticides; D063086:Organothiophosphates; D004006:Dichlorvos; D003520:Cyclophosphamide; D014236:Trichlorfon; C030064:demeton-S-methyl; D008294:Malathion; D004117:Dimethoate