title: Aneurysmal subarachnoid hemorrhage and viral infection. Lack of association.
abstract: We tested the hypothesis that intracranial aneurysm develops because of viral infection that produces arterial damage, and that aneurysmal rupture is related to viral infection. The following viral agents were studied: influenza A, influenza B, and respiratory syncytial viral titers, by the indirect immunofluorescence method, in 29 patients and 29 controls; herpes simplex virus titers, by immunofluorescence, in 31 patients and 31 controls; rubella viral titers (Rubazyme test), in 34 patients and 34 controls; and influenza A and B viral titers, by the complement fixation method, in 54 patients and 54 controls. Patients were selected on the basis of documented aneurysmal subarachnoid hemorrhage. Analysis, with derivation of the chi 2 method, to compare titer levels in patients and controls for each specific viral titer did not reveal positive correlations between the viral titers and aneurysmal subarachnoid hemorrhage.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006561:Herpes Simplex / Q000150:complications / Q000276:immunology; D006801:Humans; D007251:Influenza, Human / Q000150:complications* / Q000276:immunology; D002532:Intracranial Aneurysm / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D010253:Respirovirus Infections / Q000150:complications / Q000276:immunology; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000209:etiology*
chemical_list: D000914:Antibodies, Viral