Sarcoid myopathy with elevated creatine phosphokinase.
Acute inflammatory myopathy complicating sarcoidosis is rare, and its prognosis and appropriate therapy have not been defined well. We describe a patient with chronic sarcoidosis who, during a 3-month period, developed an acute proximal myopathy associated with marked elevations in creatine phosphokinase (CPK) and extensive granulomatous inflammation on muscle biopsy. High-dose corticosteroids were dramatically effective in inducing remission, with resolution of all signs and symptoms of the myopathy and normalization of CPK.
D000328:Adult; D001706:Biopsy; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology
D003402:Creatine Kinase; D011241:Prednisone