Amiodarone-induced vasculitis and polyserositis.
A dose-dependent cutaneous leukocytoclastic vasculitis developed in a 34 year old man who was given amiodarone for supraventricular tachycardias resistant to other drugs. This adverse reaction disappeared within 2 weeks after discontinuation of amiodarone despite its very long half-life of 52 days in this patient. During previous treatment periods with amiodarone, the patient had experienced photosensitivity and dose-dependent polyserositis. Since high doses of amiodarone have been recently proposed for the treatment of resistant cardiac arrhythmias, dose-dependent adverse effects as described here may be encountered with increasing frequency.
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001572:Benzofurans / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009336:Necrosis; D010787:Photosensitivity Disorders / Q000139:chemically induced; D012700:Serositis / Q000139:chemically induced; D013610:Tachycardia / Q000188:drug therapy; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000473:pathology
D001572:Benzofurans; D000638:Amiodarone