[The cell population kinetics of established human uterine cervical carcinoma in nude mice, with comparative examination by types of tissues].
In order to clarify the cell kinetics as the biological features of human squamous cell cancer in uterine cervix, analysis was conducted on the cells of this cancer in nude mice to which various strains had been transplanted. The results of autoradiography revealed LI = 23 approximately 35.9%, Tc = 15 approximately 23 hours, and GF = 42.4 approximately 67.3%. The values for the small-cell non-keratinizing type were generally higher than in the other types. The results of FCM revealed G1 = 49.4 approximately 66.0%, S = 24.8 approximately 38.3%, and G2 approximately M = 5.8 approximately 17.7%. The results of comparison of tissue types were identical with those of paragraph 1. The results of calculation of the numbers of non-proliferative cell compartments on the basis of the results of autoradiography and FCM revealed Q1 = 26.7 approximately 44.9%, and Q2 = 0.84 approximately 10.5%. From these findings, the Q1/G1 ratio was found to be 50 approximately 70%. The comparison by types of tissues revealed the order small cell non-keratinizing less than large cell non-keratinizing less than keratinizing. From the above findings, it was regarded as very likely that the types of tissues and the cell kinetics in the cases with squamous cell cancer in the uterine cervix are closely related to each other.
D000818:Animals; D001345:Autoradiography; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002453:Cell Cycle; D005260:Female; D006801:Humans; D007399:Interphase; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D002583:Uterine Cervical Neoplasms / Q000473:pathology*