title: The norepinephrine and dopamine content of the cat carotid body in vivo under normoxic and hypoxic conditions.
abstract: The norepinephrine (NE) and dopamine (DA) content of the cat carotid body (CB) in vivo was investigated under normoxic and hypoxic conditions (5% O2 for 1 h) by radiolabelling method. To avoid a large scattering of the measured values due to inhomogeneity of the biological material, young sib animals were used. The mean NE content under normoxia was 617 +/- 184 pmol/CB, and the mean DA content 451 +/- 200 pmol/CB. Under hypoxia, NE and DA were lowered significantly by 37% and 30%, respectively. From these results we conclude that both transmitters with their known excitatory and inhibitory actions probably influence the chemoreceptive elements in the carotid body.
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000032:analysis*; D002415:Cats; D004298:Dopamine / Q000032:analysis*; D005260:Female; D000860:Hypoxia / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000032:analysis*
chemical_list: D004298:Dopamine; D009638:Norepinephrine