Fast, low-temperature preparation of carrier-free 17-123I-heptadecanoic acid applied for liver and heart scintigraphy.
A high-yield method for labelling 17-I-heptadecanoic acid with 123I is described, and a clinical evaluation of the radiopharmaceutical is given. The labelling procedure is based on the use of a conventional ultrasonic bath. It was found that the addition of thiosulphate to the reaction medium avoids the formation of labelled side products and increases the yield considerably. The carrier-free 17-123I-heptadecanoic acid (2 mCi) in 6% human serum albumin was injected IV for heart and liver studies on selected patients with cirrhosis (alcoholic, post-necrotic) and diabetes.
D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging; D005227:Fatty Acids; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008104:Liver Cirrhosis, Alcoholic / Q000000981:diagnostic imaging; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging; D013696:Temperature; D013997:Time Factors
D005227:Fatty Acids; C027252:17-iodoheptadecanoic acid