Monocyte escape through a glomerular capillary basement membrane gap. An ultrastructural observation in a case of acute glomerulonephritis.
A focal discontinuity of glomerular basement membrane (GBM) with extravasation of a monocyte is described in a case of acute postinfectious glomerulonephritis in a 2-year-old girl. It is proposed that also monocytes could play a role in causing disruption of glomerular capillary wall. Moreover, this finding gives morphologic support to the hypothesis that monocyte-forming crescents reach the urinary space through GBM gaps.
D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D002196:Capillaries / Q000648:ultrastructure; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000473:pathology*; D008854:Microscopy, Electron; D009000:Monocytes / Q000473:pathology*