Hemoglobin San Diego/beta zero thalassemia in a Greek adult.
Interaction of beta zero thalassemia with Hb San Diego [a high affinity hemoglobin variant, alpha 2 beta (2)109(G11)Val----Met] in a 29-year-old Greek male is described. A marked polycythemia with low MCH and MCV, but minor clinical problems were observed. Functional properties of the isolated variant are described.
D000328:Adult; D000495:Allosteric Site; D006455:Hemoglobins, Abnormal / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism; D010455:Peptides / Q000032:analysis; D011086:Polycythemia / Q000097:blood; D011487:Protein Conformation; D013789:Thalassemia / Q000097:blood*
D006455:Hemoglobins, Abnormal; D010455:Peptides; C028906:hemoglobin San Diego; D010100:Oxygen