Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo.
Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP greater than Br2MBP approximately equal to F2MBP). The monohalogen ClMBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and ClMBP inhibit bone resorption in vivo, Cl2MBP most strongly.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D004164:Diphosphonates / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D010006:Osteoblasts / Q000187:drug effects; D010084:Oxidation-Reduction; D051381:Rats
D004164:Diphosphonates; D005227:Fatty Acids; D007773:Lactates; D019344:Lactic Acid; D000469:Alkaline Phosphatase