[Thymic hormonal effects on the antigen-dependent differentiation of accessory T-lymphocytes in the humoral immune response].
In the conditions of experimental deficiency of serum thymic factor (FTS) theophylline (TP) recovers in the post--thymic precursors of helper T lymphocytes an ability for differentiation to the effector regulatory stage and inhibits this process in the normal conditions. In the same conditions fraction 2 of thymosin (F2T) recovers this process and in combination with TP can relieve its opposite effects. The diversity of action of F2T on the differentiation of the post--thymic precursors of helper T lymphocytes is accounted for by the possibilities of realisation of the F2T and STF hormonal signals to these cells which depend on the condition of their specific receptors controlled by intracellular cAMP levels.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000938:Antigen-Presenting Cells / Q000187:drug effects* / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D006854:Hydrocortisone / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013806:Theophylline / Q000494:pharmacology; D013934:Thymectomy; D013935:Thymic Factor, Circulating / Q000172:deficiency; D013947:Thymosin / Q000494:pharmacology; D013951:Thymus Hormones / Q000494:pharmacology*
D007106:Immune Sera; D013951:Thymus Hormones; D013947:Thymosin; D013935:Thymic Factor, Circulating; D013806:Theophylline; D006854:Hydrocortisone
Gormonal'nye vliianiia timusa na antigenzavisimuiu differentsirovku vspomogatel'nykh T-limfotsitov gumoral'nogo immunnogo otveta.