Impaired antibiotic entry into lung tissue following acid injury.
The purpose of this study was to compare the lung tissue burden of intravenous (i.v.) and intrabronchial (i.b.) cefazolin, using a standardized hydrochloric acid injury to the lungs. Ten mongrel dogs were anesthetized with pentobarbital and artificially ventilated. Following administration of cefazolin i.v. (N = 5) or i.b. (N = 5), lung biopsies were obtained at 6 hourly intervals. Simultaneous serum levels were also determined. The effective time (Teff) was defined as the period during which all serum and lung specimens demonstrated antibiotic activity exceeding 8 mcg/gm. These levels should provide comprehensive coverage of common lung and wound pathogens that are sensitive to cefazolin. Teff for the i.v. group was 1 hour, while aerosolized cefazolin never produced lung levels exceeding 8 mcg/gm. Thus, these findings suggest an explanation for cefazolin failure in gram negative pneumonia.
D000336:Aerosols; D000818:Animals; D002437:Cefazolin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D006851:Hydrochloric Acid; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism*; D055370:Lung Injury; D011014:Pneumonia / Q000188:drug therapy / Q000378:metabolism
D000336:Aerosols; D002437:Cefazolin; D006851:Hydrochloric Acid