H-Y transplantation antigen in human XO females.
When sensitized with human cultured fibroblasts of the XY and XO, but not XX, sex chromosomal types C57BL/6 female mice reject syngeneic male grafts accelerated (second set graft reaction). These findings demonstrate that the antigenic determinants of H-Y antigen of man and mouse are homologous and that XO females (at least those tested) carry the H-Y transplantation antigen. The results are discussed in the light of the question of differences between the H-Y antigen as defined by grafting and serology and the chromosomal localization of the H-Y structural gene(s).
D000818:Animals; D002478:Cells, Cultured; D002874:Chromosome Mapping; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D005796:Genes; D006084:Graft Rejection; D006182:H-Y Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014424:Turner Syndrome / Q000235:genetics / Q000276:immunology*
D006182:H-Y Antigen