Reticular formation of the lower brainstem. A common system for cardio-respiratory and somatomotor functions. Considerations aided by computer simulations.
Parallel investigations were done using the reticular formation of the lower brainstem of dogs and computer simulated neuronal networks with properties of reticular neurones. By the aid of the simulations, understanding of the functional organisation of the common brainstem system, reticular formation and the experiments performed were optimized. The fact that discharge sequences of model neurones are very similar to those of reticular neurones was proved by interval histograms and covariance histograms. Discharges of neighbouring reticular neurones tend to be strongly coupled. In the model the discharges of the neurones could be coupled by common afferent inflows. Physiologically, neighbouring reticular neurones receive common afferents from peripheral somato-sensory systems. Neighbouring neurones with strongly coupled discharging are organized in subpopulations. The configurations of the subpopulations are determined by number and type of afferents actively influencing neurones and by the level of intrinsic activity of the network. Signal processing and transfer by neuronal subpopulations depend on the level of activity and on the degree of coupled discharging, i.e. the local organisation of the neurones.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D003201:Computers; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000294:innervation*; D008168:Lung / Q000294:innervation*; D008526:Medulla Oblongata / Q000502:physiology; D008564:Membrane Potentials; D008959:Models, Neurological; D009132:Muscles / Q000294:innervation*; D009415:Nerve Net / Q000502:physiology; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology; D012154:Reticular Formation / Q000502:physiology*