Effects of an intravenous bolus calcium injection on glomerular filtration rate and electrolyte excretion in the kidney in conscious pigs.
This paper reports the changes observed in the concentration of various constituents of plasma and in their excretion in the urine after a bolus intravenous injection of 2,2 mM calcium gluconate into conscious pigs weighing 20 kg. In the plasma, both ionic and total calcium concentrations increased but returned to normal within 35 minutes, while sodium, potassium and inorganic phosphate did not change significantly. In the kidney, the urine volume, glomerular filtration rate (GFR) and fractional sodium excretion increased slightly during the first 10 minutes but became significantly depressed later. Potassium and phosphate levels decreased, the latter significantly, while the calcium concentration increased significantly and only returned to normal after 70 minutes. These results suggest that since the disturbances in urinary volume, GFR and fractional phosphate excretion persist after both the plasma calcium and urinary calcium levels have returned to normal, factors other than these calcium values may be responsible for changes in the former measurements.
D000042:Absorption; D000818:Animals; D002118:Calcium / Q000097:blood* / Q000652:urine; D002125:Calcium Gluconate / Q000494:pharmacology*; D004573:Electrolytes / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D005942:Gluconates / Q000494:pharmacology*; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013552:Swine; D013997:Time Factors
D004573:Electrolytes; D005942:Gluconates; D010710:Phosphates; D012964:Sodium; D011188:Potassium; D002125:Calcium Gluconate; D002118:Calcium