title: Efforts toward combined analgesic/antidepressants: synthesis and evaluation of (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines.
abstract: Several (3-aryl-2,3-dihydrobenzofuran-3-yl)alkanamines, designed as potential antidepressant agents with analgesic properties, were synthesized and pharmacologically evaluated. While two compounds (1a, 1f) displayed potent antitetrabenazine activity, concomitant antinociceptive activity in the phenylquinone writhing assay was not observed.
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis*; D001572:Benzofurans / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D051379:Mice; D013747:Tetrabenazine / Q000037:antagonists & inhibitors
chemical_list: D000588:Amines; D000700:Analgesics; D000928:Antidepressive Agents; D001572:Benzofurans; D013747:Tetrabenazine