title: Preleukemia and leukemia with 12p- and 19q+ chromosome alterations following Alkeran therapy.
abstract: Among 20 patients with acute nonlymphocytic leukemia or dysmyelopoietic preleukemia secondary to Alkeran therapy for another tumor, four had a del(12)(p11-p12) and four had a translocation to 19q13 among multiple karyotypic alterations in their neoplastic hematopoetic clones. It is suggested that these two cytogenetic abnormalities may occur nonrandomly in such hemic disorders and may play a limited role in their pathogenesis.
mesh_terms: D002872:Chromosome Deletion; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000235:genetics*; D008558:Melphalan / Q000009:adverse effects*; D011289:Preleukemia / Q000139:chemically induced / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D008558:Melphalan