Correspondence of the monocyte antigen HMA-1 to the non-HLA antigen 9a.
Monocyte-specific antibodies are detrimental to bone marrow and renal transplantation. By using human antimonocyte sera we were able to identify two monocyte-specific antigens, human monocyte antigen 1 and 2 (HMA-1 and HMA-2). The presence of HMA-1 and HMA-2 was compared with the presence of several non-HLA antigens. In panel and inhibition studies, HMA-1 corresponded to the previously described non-HLA granulocyte antigen 9a. Absorption studies showed that HMA-1 and 9a were both present on granulocytes and monocytes. The clinical relevance of these antigens is discussed.
D000954:Antigens, Surface / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D009000:Monocytes / Q000276:immunology*
D000954:Antigens, Surface; D007519:Isoantigens