Plasma cell generation inhibition in lymphocyte cultures containing cerebrospinal fluid from children with central nervous system viral infections.
Plasma cell generation in pokeweed mitogen-pulsed lymphocyte cultures was markedly suppressed when the experiments were carried out by adding cell-depleted cerebrospinal fluid (CSF) from 5 acute aseptic meningitis or meningoencephalitis children known to have an overexpanded cell population with the suppressor-cytotoxic T-cell surface phenotype in their CSF. In contrast, B-cell terminal differentiation was not affected by the addition of CSF from 5 control children with non-neurological diseases, thereby indicating that CSF from central nervous system virus-infected children contains soluble factors which are themselves capable of exerting regulatory influences on immunocompetent cells.
D000293:Adolescent; D002478:Cells, Cultured; D002648:Child; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008581:Meningitis / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid* / Q000276:immunology; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid* / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology*; D014777:Virus Diseases / Q000134:cerebrospinal fluid* / Q000276:immunology