Digitalis-induced augmentation of cardiopulmonary baroreflex control of forearm vascular resistance.
We sought to determine whether digitalis augments cardiopulmonary baroreflex control of forearm vascular resistance in normal young men. Cardiopulmonary baroreceptor input was reduced with lower body negative pressure (LBNP) at 10 and 20 mm Hg, which decreased central venous pressure but did not alter blood pressure or heart rate. Decreases in forearm blood flow and increases in forearm vascular resistance with LBNP were greater after administration of lanatoside C (Cedilanid) than before, and the slope of the regression line relating changes in central venous pressure and those in forearm vascular resistance was steeper after lanatoside C. Vasoconstrictor responses to the cold pressor test did not differ before and after lanatoside C, which suggested that augmented responses to LBNP after the drug were not caused by a generalized change in reflex control. These results suggest that lanatoside C augments the tonic inhibitory influence of cardiopulmonary baroreceptors in normal men.
D000328:Adult; D003080:Cold Temperature; D004071:Digitalis Glycosides / Q000494:pharmacology*; D005542:Forearm / Q000098:blood supply; D006321:Heart / Q000294:innervation; D006801:Humans; D007799:Lanatosides / Q000494:pharmacology; D008168:Lung / Q000294:innervation; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D011312:Pressure; D012018:Reflex / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects*
D004071:Digitalis Glycosides; D007799:Lanatosides; D012965:Sodium Chloride; C018548:lanatoside C