Translocation t(1;3)(p36;q21) in malignant myeloid stem cell disorders.
A t(1;3)(p36;q21) translocation was found in bone marrow samples of two patients with hematologic disorders. One patient had a myelodysplastic syndrome evolving into acute nonlymphocytic leukemia (ANLL) M1 and the second patient had ANLL-M6 secondary to treatment for Hodgkin's disease. Because myelodysplastic syndromes and secondary leukemia are stem cell disorders, the t(1;3)(p36;q21) appears to be a chromosome abnormality in malignant myeloid stem cells.
D000208:Acute Disease; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D005260:Female; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D014178:Translocation, Genetic