Increased basal and reactive plasma norepinephrine and epinephrine levels in awake DOCA-salt hypertensive rats.
The sympatho-adrenal basal tone and reactivity were studied using plasma norepinephrine (NE) and epinephrine (E) levels in awake DOCA-salt hypertensive rats. In those animals, basal NE and E levels were about twice greater than those found in normotensive rats. Moreover, plasma NE levels could be significantly correlated with mean arterial pressures in both groups of animals. Following a hemorrhagic hypotension, elevation in NE and E levels tended to be greater in hypertensive rats. These studies suggest that the basal activity of the sympatho-adrenal system is increased and that its reactivity might be potentiated in DOCA-salt hypertension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004837:Epinephrine / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D007022:Hypotension / Q000097:blood; D009638:Norepinephrine / Q000097:blood*; D051381:Rats; D011918:Rats, Inbred SHR
D003900:Desoxycorticosterone; D009638:Norepinephrine; D004837:Epinephrine