Serum pepsinogen I levels in relation to pepsinogen phenotypes.
Serum PG I levels were measured by an enzyme linked immuno sorbent assay (ELISA) in 567 blood donors and 171 patients from a routine gastroscopy program to study the relationship between PG I phenotypes and serum levels. In normal subjects no association was found between PG I phenotypes and serum levels. A low serum PG I level in patients was associated with phenotypes characterized by intense PG I fraction 5. This probably reflects the high frequency of these phenotypes in patients with atrophic gastritis or gastric cancer. The mean (+/- SD) serum PG I level was 45.8 +/- 17.7 micrograms/1 in control subjects. Serum PG I levels were lower in females (41.4 +/- 17.5) than in males (47.3 +/- 17.7) and increased with advancing age up to 65 years.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020116:Pepsinogen A; D010435:Pepsinogens / Q000032:analysis / Q000097:blood* / Q000235:genetics; D010641:Phenotype; D013272:Stomach Diseases / Q000097:blood
D010435:Pepsinogens; D020116:Pepsinogen A