title: Effect of halogenmethylenebisphosphonates on bone cells in culture and on bone resorption in vivo.
abstract: Dihalogenmethylenebisphosphonates increase alkaline phosphatase activity and fatty acid oxidation in calvaria cells in culture (Cl2MBP greater than Br2MBP approximately equal to F2MBP). The monohalogen ClMBP and the non-halogenated analogues are less active on phosphatase and inactive on or inhibitory towards fatty acid oxidation. The three dihalogenbisphosphonates and ClMBP inhibit bone resorption in vivo, Cl2MBP most strongly.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D004164:Diphosphonates / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D010006:Osteoblasts / Q000187:drug effects; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D004164:Diphosphonates; D005227:Fatty Acids; D007773:Lactates; D019344:Lactic Acid; D000469:Alkaline Phosphatase