Increased hepatotoxicity of acetaminophen by concomitant administration of caffeine in the rat.
Since caffeine is frequently co-administered with acetaminophen, it is of clinical interest to study the effect of caffeine on the hepatotoxicity of acetaminophen. In male Sprague-Dawley rats fasted for 18 h, concomitant administration of caffeine (0.1 g/kg, i.p.) as judged by increased serum enzyme activities and increased incidence of hepatic necrosis. Careful observations on hepatotoxicity are suggested when acetaminophen is prescribed with caffeine.
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002110:Caffeine / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury; D004347:Drug Interactions; D008107:Liver Diseases / Q000201:enzymology / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D000082:Acetaminophen; D002110:Caffeine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase