Lack of DNA-strand breaks in rat testicular cells after in vivo treatment with sodium fluoride.
Oral administration of up to 84 mg/kg of NaF to adult male rats did not induce DNA-strand breaks in testicular cells when measured by alkaline elution. Although plasma fluoride levels were as high as 12 ppm is rats given 84 mg/kg of NaF, testicular fluoride levels in most cases were only 10-20% of plasma levels. Fluoride did not accumulate in the testes after 5 daily treatments. Therefore, it is unlikely that NaF, even at high doses, poses a hazard with respect to heritable genetic effects.
D000818:Animals; D004247:DNA / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000032:analysis / Q000097:blood; D006801:Humans; D008297:Male; D009153:Mutagens; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D013737:Testis / Q000032:analysis / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D009153:Mutagens; D012969:Sodium Fluoride; D004247:DNA; D005459:Fluorides