title: Gynecological follow-up of parkinsonian patients on long-term bromocriptine treatment.
abstract: Bromocriptine given for prolonged times at high doses has been found to induce tumors in the uterus in aged rats. To elucidate the possible tumorigenic effect of long-term treatment with bromocriptine in humans, 35 women treated with this drug for chronic parkinsonism were studied. For each patient a gynecological anamnesis and examination were performed; one or several cervicovaginal smears and endometrial samples were also taken, by jetwash. No evidence of malignant changes was seen. Thus, in this respect bromocriptine would appear to be a safe drug, even for long-term use.
mesh_terms: D000328:Adult; D000368:Aged; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects; D014626:Vaginal Smears; D014844:Vulva / Q000187:drug effects
chemical_list: D001971:Bromocriptine