Nonrandom chromosome alterations in rhabdomyosarcoma.
Chromosome banding analysis was attempted on tumor cells from a total of six rhabdomyosarcomas. Results revealed a variety of chromosome alterations, including frequent structural rearrangement of chromosome #1 and the finding in one patient of multiple double minutes. The single chromosome most consistently involved in structural rearrangements was #3. Simple deletion or translocation of either the long or short arm of chromosome #3 was found in all rhabdomyosarcoma tumors examined in this report. Further, a review of the limited previous literature on rhabdomyosarcoma provided further support for the frequent alteration of chromosome #3 in this disease. Results from our study provide preliminary evidence that alterations of chromosome 3p14-21 may represent a site of nonrandom chromosome change in rhabdomyosarcoma.
D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D006801:Humans; D007621:Karyotyping; D012208:Rhabdomyosarcoma / Q000235:genetics*; D014178:Translocation, Genetic