Effect of dimethyl sulfoxide and glycerol on acute bowel ischemia in the rat.
After a 30 minute period of superior mesenteric artery occlusion in adult rats, there was a significant decrease in peritoneal inflammatory reaction, ileus, peritoneal adhesion formation, and histologically proved bowel wall necrosis in animals given intravenous dimethyl sulfoxide at the end of the ischemic period. In contrast, control rats given normal saline solution intravenously demonstrated severe inflammatory reaction, ileus, hemorrhagic peritoneal fluid, extensive adhesion formation, and areas of bowel wall necrosis. Intravenous glycerol did not have the beneficial effect seen with dimethyl sulfoxide. Neither compound was effective when given intraperitoneally. We conclude that intravenous dimethyl sulfoxide has a significant protective effect in rats with acute intestinal ischemia due to the superior mesenteric artery occlusion in the rat.
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D005990:Glycerol / Q000494:pharmacology*; D006465:Hemoperitoneum / Q000209:etiology; D007415:Intestinal Obstruction / Q000209:etiology; D007511:Ischemia / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D008297:Male; D008638:Mesenteric Arteries; D008641:Mesenteric Vascular Occlusion / Q000150:complications; D010538:Peritonitis / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D000267:Tissue Adhesions / Q000209:etiology
D005990:Glycerol; D004121:Dimethyl Sulfoxide