[Abnormal sugar chains found in tumor glycoproteins].
Comparative study of the asparagine-linked sugar chains of hCGs purified from urine of pregnant women and of choriocarcinoma patients revealed that extensive and structural changes occur common in the sugar chains of tumor hCGs. The changes can be ascribed to enhancement of an alpha-fucosyltransferase that forms the Fuc alpha 1----6GlcNAc group in the sugar chains and the appearance of N-acetylglucosaminyltransferase IV.
D001216:Asparagine / Q000032:analysis; D002822:Choriocarcinoma / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000032:analysis*; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D008970:Molecular Weight; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000032:analysis*
D006063:Chorionic Gonadotropin; D006023:Glycoproteins; D001216:Asparagine