In vitro effect of cadmium on primary antibody response to T-cell independent antigen (DNP-Ficoll).
The effect of various concentrations of cadmium on the in vitro primary antibody response to T-cell independent antigen (DNP-Ficoll) was investigated. Anti DNP-Ficoll antibody response in mice was significantly enhanced by 8 microM cadmium, but suppressed by 20 and 40 microM cadmium. However, cell viabilities were decreased by cadmium exposure with dose-dependent relationships. The results suggest that in vitro exposure to cadmium produces different effects on antibody responses.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002104:Cadmium / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011134:Polysaccharides / Q000276:immunology*
C031007:DNP-Ficoll; D011134:Polysaccharides; D002104:Cadmium; D005362:Ficoll