Giant cell myocarditis: evidence for the macrophage origin of the giant cells.
In order to elucidate the origin of giant cells in giant cell myocarditis a case has been studied immunohistologically using monoclonal antibodies against a variety of antigens, including those associated with muscle and macrophages. The results strongly suggest that the giant cells are derived from macrophages rather than the muscle cells.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology; D009205:Myocarditis / Q000473:pathology*; D009206:Myocardium / Q000648:ultrastructure
D000911:Antibodies, Monoclonal