title: Circulatory effects of splanchnic nerve stimulation in developing swine.
abstract: The relative maturity of immediate intestinal circulatory responses to efferent splanchnic nerve stimulation for 20 s was tested in 34 piglets (1 day-1 mo old) under pentobarbital anesthesia (15-30 mg/kg). Aortic pressure, heart rate, and superior mesenteric arterial flow (measured by electromagnetic flow transducers) were recorded simultaneously. Intestinal vascular resistance was calculated as mean aortic pressure/mean arterial flow. Resistance increased in most animals during experimental inhibition of the carotid sinus baroreceptor reflex. Transection of the splanchnic nerve decreased mesenteric resistance in all animals. Nerve stimulation at 2 Hz was not effective in all of the youngest animals; at 3 Hz, mesenteric resistance increased in all animals. The latency of this response was shorter at each increase in stimulation frequency. The aortic pressure rise associated with splanchnic nerve stimulation was greater with each increase in frequency. This rise was attenuated or absent after adrenalectomy and during postganglionic fiber stimulation. The vasoconstrictor effect of splanchnic nerve stimulation was attenuated after alpha-adrenergic receptor blockade with phentolamine in a dose (0.25-0.75 mg/kg) that blocked vasoconstrictor effects of norepinephrine (0.5 micrograms/kg). We conclude that alpha-adrenergic mechanisms are functional, although not mature, and that sympathetic vasoconstrictor tone is present in the intestinal circulation of swine at birth.
mesh_terms: D000315:Adrenalectomy; D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001011:Aorta; D001794:Blood Pressure; D004558:Electric Stimulation; D007422:Intestines / Q000098:blood supply*; D008638:Mesenteric Arteries; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011930:Reaction Time; D012039:Regional Blood Flow; D013153:Splanchnic Nerves / Q000502:physiology*; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D009638:Norepinephrine; D010646:Phentolamine