Inhibition of contact sensitivity reactions to DNFB by topical cyclosporin application in the guinea-pig.
Contact sensitivity skin reactions to dinitrofluorobenzene (DNFB) were inhibited by twice daily topical application of cyclosporin (CsA, 2%) in normal guinea-pigs and in those with enhanced contact sensitivity reactions following pre-treatment with cyclophosphamide. In contrast to oral administration of CsA (25 mg/kg) for 4 days, topical application of the drug over the same period did not result in systemic absorption (as measured by radioimmunoassay) or in any evidence of nephrotoxicity.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003524:Cyclosporins / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control*; D004139:Dinitrofluorobenzene; D006168:Guinea Pigs; D006854:Hydrocortisone; D008297:Male; D011863:Radioimmunoassay; D012882:Skin Tests
D000893:Anti-Inflammatory Agents; D003524:Cyclosporins; D004139:Dinitrofluorobenzene; D006854:Hydrocortisone