title: Depression of postejaculatory ultrasonic vocalization by (+)-bicuculline.
abstract: The male rat emits ultrasonic (22 kHz) vocalizations after ejaculation and behavioural and electrophysiological evidence suggests that this vocalization reflects an inhibitory state underlying and determining the postejaculatory refractory period (PEI). Present results show that injection into the preoptic-anterior hypothalamic area of (+)-bicuculline methiodide, a GABA antagonist, shortens the PEI and reduces ultrasonic vocalization. It is suggested that the suppression of ultrasonic vocalization following bicuculline treatment reflects a depression of an inhibitory state normally produced by ejaculation.
mesh_terms: D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology*; D001931:Brain Mapping; D004542:Ejaculation / Q000187:drug effects*; D008297:Male; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D014465:Ultrasonics; D014828:Vocalization, Animal / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005680:gamma-Aminobutyric Acid; D001640:Bicuculline