Toxicity of intravitreal interferon.
We evaluated the toxicity of injecting human fibroblast interferon intravitreally in rabbit eyes. A single intravitreal injection of 166,660 units/0.1 ml was nontoxic to ocular structures, as demonstrated by electroretinographic and histologic examination.
D000818:Animals; D004596:Electroretinography; D006801:Humans; D007267:Injections; D007370:Interferon Type I / Q000008:administration & dosage / Q000009:adverse effects*; D011817:Rabbits; D014822:Vitreous Body / Q000187:drug effects*
D007370:Interferon Type I