title: Heparin-induced thrombocytopenia and recurrent thromboembolism in siblings.
abstract: Two brothers with heparin-induced thrombocytopenia and multiple arterial and venous thromboembolism affecting peripheral vessels are described. Heparin-dependent antiplatelet antibody was detected using platelet aggregometry in both patients. Although these observations may be coincidental, the possibility of familial occurrence of this adverse reaction to heparin cannot be excluded with certainty.
mesh_terms: D004198:Disease Susceptibility; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D012008:Recurrence; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000235:genetics; D013923:Thromboembolism / Q000097:blood / Q000139:chemically induced* / Q000235:genetics; D013997:Time Factors
chemical_list: D006493:Heparin