[Effectiveness of protecting the myocardium against ischemia with a normothermic cardioplegic solution and creatine phosphate].
The protective effects of cardioplegic solutions (CS) containing creatine phosphate (CP) were studied in a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest. Isolated rat hearts were subjected to a 3-minute coronary infusion with CS containing CP in normothermic (37 degrees C) and hypothermic (4-6 degrees C) regimes. In the normothermia group, the postischemic functional recovery was 70-75% of the preischemic control value, while the cellular ATP and CP content was reduced but insignificantly. By contrast, in the hypothermia group, the postischemic functional recovery was markedly depressed, with the tissue high-energy phosphate content being appreciably lowered. The data obtained confirm high efficacy of CP-containing cardioplegic solutions administered under normothermia conditions.
D000255:Adenosine Triphosphate; D000818:Animals; D003327:Coronary Disease / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D006324:Heart Arrest, Induced / Q000379:methods*; D007036:Hypothermia, Induced; D066298:In Vitro Techniques; D008297:Male; D010725:Phosphocreatine; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions
D012996:Solutions; D010725:Phosphocreatine; D000255:Adenosine Triphosphate
Effektivnost' zashchity miokarda ot ishemii normotermicheskim kardioplegicheskim rastvorom s kreatinfosfatom.