title: Trifluoperazine and calcium antagonists accelerate cholinergic desensitization in Aplysia neurons.
abstract: The onset of desensitization of excitatory acetylcholine responses in isolated, voltage clamped Aplysia RB neurons to microperfused agonist was accelerated by trifluoperazine and the calcium antagonists SKF-525A and D-600. In the absence of these drugs the time course of desensitization is described as the sum of two exponentials plus a constant. All 3 compounds accelerated the fast exponential component of desensitization, but had opposite effects on the slow component: trifluoperazine and SKF-525A accelerated the slow component, whereas this phase was greatly slowed by D-600. These results provide further evidence that the two components of cholinergic desensitization may be independent and influenced by agents which may affect calcium binding to the acetylcholine receptor.
mesh_terms: D000818:Animals; D001048:Aplysia; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005711:Gallopamil / Q000494:pharmacology; D005724:Ganglia / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D011335:Proadifen / Q000494:pharmacology; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D011978:Receptors, Nicotinic; D014268:Trifluoperazine; D005711:Gallopamil; D011335:Proadifen; D002118:Calcium