title: [Local and transcutaneous pharmacotherapy. Pharmacokinetic principles and clinical evaluation].
abstract: The pharmacological and pharmacokinetic postulates and preconditions for the various kinds of pharmaco-therapy (topical, systemic and transcutaneous) are presented. Taking into consideration mathematical and physical principles as well as anatomical and physiological factors, the possibilities for influencing the flow of drugs into and through the skin are described (choice of vehicle and concentrations, permeation enhancers). In the clinical part of the study, it is shown that following these guidelines can lead to new forms of therapy and to safer application of drugs and cosmetics.
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000818:Animals; D001452:Balneology; D001682:Biological Availability; D002199:Capillary Permeability / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003872:Dermatitis / Q000097:blood / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D003879:Dermatologic Agents
vernacular_title: Die lokale und transkutane Pharmakotherapie. Pharmakokinetische Grundlagen und klinische Bewertung.