Cytologic diagnosis of endometrial adenocarcinoma using the Endo-pap sampler.
Six hundred ambulatory women were screened with the Endo-pap cytology sampler in two medical centers. None of the women developed complications from the use of the instrument. Their smears were routinely processed together with cervical cytology smears. One hundred fifty-three of these women had a tissue diagnosis by endometrial biopsy, dilatation and curettage, or hysterectomy. Adequate cytology specimens were obtained in 93% of these patients. In these 153 patients, 32 (18%) had a tissue diagnosis of endometrial adenocarcinoma, and 31 patients had a tissue diagnosis of endometrial hyperplasia. The cytology samples obtained with this device were diagnostic of endometrial adenocarcinoma in 30 (94%) of these 32 patients and ten (32%) of the patients with endometrial hyperplasia. Two patients (1.6%) were diagnosed falsely positive. The Endo-pap cytology sampler is considered a safe and effective screening tool for endometrial adenocarcinoma. Its value in diagnosing endometrial hyperplasia remains to be determined.
D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D004717:Endometrium / Q000473:pathology; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000473:pathology*; D014626:Vaginal Smears / Q000295:instrumentation* / Q000592:standards