[Mathematical model for estimating the ratio of cells having passed the different number of divisions in the culture].
Different versions of the stochastic expansion of the continuous determined linear model proposed formerly for evaluation of the ratio of cells having passed the different number of divisions in the culture were worked out and theoretically based. The influence of approximation precision of the continuous model by its discrete analogues on the adequacy of the process under study was examined. The problem of simultaneous identification of unknown parameters and the model's primary conditions was solved. The proposed methods for construction of the stochastic models for evaluation of the ratio of cells having passed the different number of divisions in the culture make it possible not only to determine analytically the correlation of metaphases of the first, second, third and following divisions at definite times of fixation and under different conditions, but also to evaluate reliability of the results obtained.
D002452:Cell Count; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008433:Mathematics; D008954:Models, Biological
Matematicheskie modeli dlia otsenki sootnosheniia kletok, proshedshikh raznoe chislo deleniĭ v kul'ture.