Autoantibody to albumin of type G and M in acute and chronic viral hepatitis.
Autoantibodies to albumin (AAA) were tested by an ELISA method in patients with A, B and NANB acute and chronic hepatitis, and in a control group. AAA-IgM had a different behaviour in acute hepatitis type A, in which we observed a high average titre as compared with B, and NANB hepatitis, in which we observed a decrease in the average titre. In the chronic phase, we noted a decrement of the average titre in all the types of hepatitis. For AAA-IgG, in the acute phase the average titre in hepatitis A, B and NANB was lower than in the control group. In the chronic stage, only NANB hepatitis showed a decrement of the average titre of the antibody. On the base of these results, we can say that the involvement of AAA seems to be different in hepatitis A from the other two types, in which the decrement of average titre may be explained by the formation of immunocomplexes which are not detected by this test.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D002353:Carrier State / Q000276:immunology; D002648:Child; D005260:Female; D006521:Hepatitis, Chronic / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000276:immunology*; D000075462:Serum Albumin, Human
D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin; C032137:polyalbumin; D000075462:Serum Albumin, Human