[Kinetics of 3H-remantadine accumulation and excretion in the tissues of pregnant mice and their fetuses].
The authors studied the pharmacodynamics of remantadin in fetuses, liver, kidneys and spleen of pregnant mice after a single oral administration of 3H-remantadin in a dose of 2.8 mg/kg. Thirty to 60 min after the drug administration the fetuses and tissues showed the maximal amount of the drug penetrating an organ. The greatest amount of remantadin was detected in the liver, the least amount in the kidneys and fetuses. The drug half-life in organs and fetuses did not exceed 2 hours. Twelve hours after the drug administration the kidneys and spleen demonstrated remantadin traces (less than 0.1%), the fetuses showed 0.2% and the liver about 0.7% of the drug. It is concluded that remantadin is marked by good placenta permeability and that it is completely eliminated from the fetus.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal; D012299:Rimantadine / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D014316:Tritium
D012299:Rimantadine; D014316:Tritium; D000218:Adamantane
Kinetika nakopleniia i vyvedeniia 3H-remantadina v tkaniakh beremennykh mysheĭ i plodakh.