Age-dependent enhancement of diazepam sensitivity is accelerated in New Zealand Black mice.
Separate age groups of C57BL/6 and autoimmune New Zealand Black (NZB) mice were compared for diazepam-induced ataxia and barbiturate-induced loss of righting reflex. Between 1 and 3 months of age, both strains showed a similar age-related decrease in ED50 for diazepam-induced ataxia. However, between 3 and 12 months the decrease in ED50 was markedly greater in NZB mice. In contrast, age-related increases in the durations of loss of righting reflex following hexobarbital or barbital were similar in both strains. The results suggest that NZB mice show relatively accelerated age-related increases in sensitivity to benzodiazepine, but not to barbiturates.
D000375:Aging; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001463:Barbiturates / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB / Q000502:physiology*; D012018:Reflex / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity; D013997:Time Factors
D001463:Barbiturates; D003975:Diazepam