Effects of immunological adjuvants on the mouse complement system--II. Anti-complementary effects of surface-active compounds.
The anti-complementary effects of the surface-active immunological adjuvants dimethyldioctadecylammonium bromide (DDA) and pluronic polyols L101 and L121 were investigated in the mouse system. All three adjuvants showed complement (C)-inactivating effects. DDA caused a time- and dose-dependent reduction of alternative pathway (AP) and overall C activity, which varied with the serum concentration. Polyols induced a preferential inactivation of the AP by a more direct mechanism. A rather general, causative relationship between anti-complementary and immunological adjuvant activities is suggested. This might involve interference with nonspecific elimination of antigen, counteraction of immunosuppression by terminal C components, and/or moderation of C3b-mediated reduction of Ia-expression, leading to a better antigen presentation.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D003170:Complement Pathway, Alternative / Q000187:drug effects; D003634:DDT / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011060:Poloxalene / Q000494:pharmacology; D011817:Rabbits; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D013501:Surface-Active Agents; C000849:bis(p-chlorophenyl)acetic acid; D011060:Poloxalene; D003634:DDT