title: Cytogenetic effects of epoxy resin in man: dependence on sex, age and period of exposure.
abstract: The cytogenetic analysis of 156 subjects occupationally exposed to epoxy resin has revealed sex-dependent differences: average frequencies of aberrant metaphases and chromosome breaks per cell were significantly higher in males than in females. No linear or other functional relationship between the frequency of aberrant metaphases and the period of exposure to the resin has been revealed. However, a significantly higher average frequency of aberrant metaphases was observed in the group of elderly workers with a long period of exposure. The distribution of individuals according to the frequency of aberrant metaphases in the control group does not differ significantly from Poisson's law, while in individuals exposed to epoxy resin it is closer to the normal distribution.
mesh_terms: D000328:Adult; D000367:Age Factors; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects; D004781:Environmental Exposure; D004853:Epoxy Resins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009790:Occupations; D012737:Sex Factors; D013997:Time Factors
chemical_list: D004853:Epoxy Resins