title: Benoxaprofen reduces osteophyte formation and fibrillation after articular cartilage injury.
abstract: We examined the in vivo effect of benoxaprofen on the degeneration of articular cartilage after injection of sodium iodoacetate into the guinea pig knee. As shown previously, 3 weeks after the injection, samples from the ipsilateral knee of animals that did not receive benoxaprofen invariably exhibited marked loss of chondrocytes, absence of staining with safranin-O, fibrillation, and prominent osteophytes. In contrast, in samples from animals which received daily benoxaprofen (25 mg/kg) orally after the intraarticular injection of iodoacetate, pericellular safranin-O staining persisted, cell loss was less marked, osteophyte formation was markedly diminished and fibrillation occurred in only one of 5 samples. Knee cartilage from 2 animals that received benoxaprofen but were not injected with iodoacetate exhibited focal fibrillation, which may have been unrelated to the drug. Thus, benoxaprofen exhibited a marked protective effect in this chemically induced model of cartilage injury.
mesh_terms: D000818:Animals; D002357:Cartilage Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology*; D006168:Guinea Pigs; D006651:Histocytochemistry; D007461:Iodoacetates; D019807:Iodoacetic Acid; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D013583:Synovial Membrane / Q000473:pathology
chemical_list: D007461:Iodoacetates; D011422:Propionates; C011677:benoxaprofen; D019807:Iodoacetic Acid