title: Benign mediastinal teratoma with immature elements exhibited clonal growth and motility in the human tumor clonogenic assay.
abstract: The human tumor clonogenic assay has been used to study the growth and drug sensitivity of a wide variety of malignant and a limited number of benign tumors. We conducted detailed studies on a multipotential benign teratoma from a young child that gave rise to colonies in soft agar culture. The colonies separated themselves from the surrounding agar and exhibited rapid rotary movement (15 r/min). Morphologic, ultrastructural, and immunologic studies showed the colonies to be comprised exclusively of ciliated respiratory epithelium. The uniform beating of the cilia resulted in a constant rolling motion of the colonies in a single direction.
mesh_terms: D002454:Cell Differentiation; D002465:Cell Movement; D002923:Cilia / Q000648:ultrastructure; D002999:Clone Cells / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008479:Mediastinal Neoplasms / Q000473:pathology*; D012137:Respiratory System / Q000473:pathology; D013724:Teratoma / Q000473:pathology*; D014410:Tumor Stem Cell Assay