Hemodynamic effects of rapid and slow infusions of manganese chloride and gadolinium-DTPA in dogs.
The acute hemodynamic effects of two paramagnetic contrast materials, manganese chloride and gadolinium-DTPA, were examined in dogs using ultrasonic dimension gauge crystals. Slow infusions (more than 15 minutes) of MnCl2 (0.1 mm/kg) or Gd-DTPA (0.1 mm/kg) via an infusion pump had no significant hemodynamic effects. When given in just over 1 minute, Gd-DTPA produced elevated left ventricular (LV) end diastolic pressure and minor dilation of the ventricle and slowed diastolic filling. MnCl2, given rapidly, reduced systemic vascular resistance, resulting in hypotension. It also reduced LV volume and had less marked diastolic effects (probably secondary to the amount of hypotension created). With both agents, these side effects waned after 5-10 minutes. It is concluded that both Gd-DTPA and MnCl2 can be given safely in 0.1-mm/kg doses when administered as a slow, continuous infusion. The acute hemodynamic effects of Gd-DTPA are consistent although minor. While the acute effects of Gd-DTPA are small, neither agent is sufficiently innocuous to be given as a rapid injection in clinically unstable patients. Slow, intravenous infusion of Gd-DTPA or MnCl2 is likely to be tolerated well by even severely ill individuals.
D000818:Animals; D002712:Chlorides; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005682:Gadolinium; D006439:Hemodynamics / Q000187:drug effects; D007263:Infusions, Parenteral; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000494:pharmacology*; D017895:Manganese Compounds; D004369:Pentetic Acid / Q000494:pharmacology*; D013997:Time Factors
D002712:Chlorides; D017895:Manganese Compounds; D008345:Manganese; D004369:Pentetic Acid; D005682:Gadolinium; C025340:manganese chloride