Clonal chromosome abnormalities in prison-acquired lymphoproliferative syndrome.
Lymph nodes from five male patients with prison-acquired lymphoproliferative syndrome (PALS), which seems to be a prodrome of acquired immune deficiency syndrome (AIDS), were examined cytogenetically. Two had clonal chromosome abnormalities, i.e., 11q- and -11, and another had multiple nonclonal chromosome changes, including t(2p-;3q+),6q-,+12,14q+. These chromosome changes are also common in malignant lymphoma and suggest that the patients with PALS may be predisposed to develop malignant lymphoma.
D000328:Adult; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000473:pathology; D008297:Male; D011330:Prisons; D013577:Syndrome; D009626:Terminology as Topic