title: Effect of bacterial lipopolysaccharide on serum lipids and on the development of aortic atherosclerosis in rabbits.
abstract: The effect of repeated intravenous administration of bacterial lipopolysaccharide (LPS) on serum lipids and on aortic atherosclerosis was studied in rabbits on basal diet and on hypercholesterolemic diets containing 0.15-1.0% cholesterol. LPS (10 or 100 ng/kg body weight) was administered 3 times per week for 3 or 6 weeks. No difference was observed in serum lipid levels or in aortic atherosclerosis between LPS- and saline-treated animals. These observations do not support the hypothesis that LPS has an effect on the progression of atherosclerosis.
mesh_terms: D000818:Animals; D001018:Aortic Diseases / Q000097:blood / Q000209:etiology*; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008055:Lipids / Q000097:blood*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D011817:Rabbits
chemical_list: D002791:Cholesterol, Dietary; D008055:Lipids; D008070:Lipopolysaccharides