title: Trazodone, a nontricyclic antidepressant, is an inhibitor of adenosine deaminase.
abstract: Trazodone, a nontricyclic antidepressant drug, is a noncompetitive inhibitor of adenosine deaminase. The specific activity of adenosine deaminase in rat brain cortex homogenate is 140 +/- 15 (SEM) nm/min/gm tissue, while the apparent Km of adenosine is 77 microM. The apparent Ki of trazodone for the brain cortex enzyme is 1 X 10(-4)M, and 6 X 10(-5)M for purified calf intestine mucosal enzyme.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D002417:Cattle; D002540:Cerebral Cortex / Q000201:enzymology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000201:enzymology; D007700:Kinetics; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D014196:Trazodone / Q000494:pharmacology*
chemical_list: D058892:Adenosine Deaminase Inhibitors; D010879:Piperazines; D009700:Nucleoside Deaminases; D000241:Adenosine; D014196:Trazodone