title: [Effect of a course of pentoxifylline (trental) treatment on microcirculatory and central hemodynamic functions in chronic ischemic heart disease patients].
abstract: The author studied the effect of trental therapy lasting one month on the functions of the microcirculation and central hemodynamics in 45 patients with chronic coronary heart disease (CHD). It was established that as regards the clinical response to the treatment all the patients could be distributed into 2 groups: responsive and refractory to therapy. In patients who responded to the treatment (36 persons), the rate of the microlymph flow and capillary permeability substantially increased. The increase in capillary permeability led to a lowering in the CPV and BCV, which in turn gave rise to a reduction in the parameters of the cardiac output. There were no changes on the whole in the microhemodynamics. In patients refractory to therapy, trental treatment did not bring about any changes in the central hemodynamics, microhemodynamics or lymphodynamics. Capillary permeability dropped with a high degree of significance. The data obtained point to the necessity of a differential approach to the treatment of CHD patients with trental.
mesh_terms: D000328:Adult; D002199:Capillary Permeability / Q000187:drug effects; D002908:Chronic Disease; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007866:Leg / Q000098:blood supply; D008196:Lymph / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D013805:Theobromine / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: D013805:Theobromine; D010431:Pentoxifylline
vernacular_title: Vliianie kursovogo lecheniia pentoksifillinom (trentalom) na sostoianie mikrotsirkuliatsii i tsentral'noĭ gemodinamiki u bol'nykh khronicheskoĭ ishemicheskoĭ bolezn'iu serdtsa.