White noise analysis of cable properties of neuroblastoma cells and lamprey central neurons.
The integrative properties of two kinds of excitable cells, a cultured neuroblastoma cell and the lamprey giant interneuron, are described using a white-noise impedance method. The impedance functions were fitted with a neuron model consisting of an isopotential soma plus a single equivalent dendritic process, which contained up to 16 equal elements. The frequency-domain characteristics of both the passive and active conductances were used to estimate the dendritic-to-soma areas, the electrotonic length of an equivalent dendrite, the membrane time constant, and the relaxation time constants associated with the voltage-dependent conductances. The effect of differing degrees of synaptic input was simulated by localizing the synaptically activated conductances to the soma, a point at the end of the dendrite, or the entire dendritic membrane.
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002460:Cell Line; D004594:Electrophysiology; D005399:Fishes / Q000502:physiology*; D006822:Hybrid Cells / Q000502:physiology; D007798:Lampreys / Q000502:physiology*; D051379:Mice; D008959:Models, Neurological; D009447:Neuroblastoma; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*