Radiation-induced heart disease in rats.
After local irradiation of the rat heart with X ray doses of over 10 Gy (single dose), animals developed symptoms of radiation-induced heart disease, which at higher doses would lead to fatal cardiac failure. The LD 50 at 1 year was between 15 Gy and 20 Gy. The pericardium and epicardium responded to irradiation with exudative pericarditis after 4 months. Focal myocardial damage was secondary to progressive capillary damage.
D000818:Animals; D003326:Coronary Circulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D008833:Microcirculation; D009206:Myocardium / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000473:pathology; D051381:Rats