Hexitol production by canine retinal microvessels.
Hexitol-producing activity has been quantitated in microvessels isolated from retina and cerebral cortex of dogs, a species known to develop a retinopathy similar to that seen in diabetic patients. Both the retinal and cerebral microvessels produce galactitol from galactose, but at a rate several-fold less than that seen in canine lens epithelium. This hexitol-producing activity of the microvessels is not an artifact of erythrocyte contamination and can be inhibited by the aldose reductase inhibitor, Sorbinil.
D000818:Animals; D001921:Brain / Q000098:blood supply; D002196:Capillaries / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism; D004285:Dogs; D004376:Galactitol / Q000378:metabolism*; D012171:Retinal Vessels / Q000378:metabolism*; D013402:Sugar Alcohols / Q000378:metabolism*
D013402:Sugar Alcohols; D004376:Galactitol