NMU-1, a new transplantable mouse lung tumor: biological and chemosensitivity properties in vivo.
NMU-1 is a lung adenocarcinoma induced by N-nitroso-N-methyl-urea in a BALB/c Lac Dp mouse and maintained in vivo by sc passages of tumor fragments. No spontaneous regressions have been observed. After sc implantation, NMU-1 metastasizes to the lung as shown by a bioassay. Seven established antitumoral drugs were used to evaluate the chemosensitivity of this neoplasm. Mitomycin, cyclophosphamide, and cisplatin statistically affected tumor growth, as evaluated by three end points (ie, tumor weight, increase in lifespan, and tumor growth delay). 5-FU, doxorubicin, and vincristine showed significant activity on two end points. Carmustine did not affect any end points.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea; D051379:Mice; D008807:Mice, Inbred BALB C
D000970:Antineoplastic Agents; D008770:Methylnitrosourea