[Effect of psychotropic substances on the development of alcoholic motivation in noninbred white rats].
The experiments have shown the capacity of antidepressant amitriptylin (0.5 mg/kg, i. p.) and tranquilizer phenazepam (0.1 mg/kg i. p.) to normalize the adaptive behaviour and almost completely prevent the development of alcohol motivation in animals with insufficient adaptive behaviour. It was established that in animals initially rejecting alcohol, chronic treatment with these drugs as well as d-amphetamine promoted alcohol motivation. The results obtained have proved our earlier hypothesis that preclinical search for drugs for the prevention and treatment of early stages of alcoholism is possible only in animals pre-selected according to their inclination to experimental alcoholism.
D000223:Adaptation, Psychological / Q000187:drug effects; D000428:Alcohol Drinking; D000639:Amitriptyline / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D003220:Conflict, Psychological; D003863:Depression / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009042:Motivation / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013550:Swimming; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D011619:Psychotropic Drugs; D001569:Benzodiazepines; D000639:Amitriptyline; C017928:phenazepam; D000661:Amphetamine
Vliianie psikhotropnykh veshchestv na formirovanie alkogol'noĭ motivatsii u besporodnykh belykh krys.