Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests.
Several quassinoids, obtained by isolation and derivatization from Simaba multiflora and Soulamea soulameoides, were evaluated for growth inhibitory and insecticidal effects against the tobacco budworm (Heliothis virescens) and for antifeedant effects against H. virescens and the fall armyworm (Spodoptera frugiperda). The relative activity of the quassinoids as insect growth inhibitors generally paralleled their known relative potency as antileukemic and cytotoxic agents.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D055598:Chemical Phenomena; D002621:Chemistry; D004224:Diterpenes / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005900:Glaucarubin / Q000031:analogs & derivatives / Q000494:pharmacology*; D007313:Insecta / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D007306:Insecticides; D007814:Larva / Q000187:drug effects; D010616:Phenanthrenes / Q000494:pharmacology*; D036702:Quassins
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007306:Insecticides; D010616:Phenanthrenes; D036702:Quassins; C024967:glaucarubolone; C024966:chaparrinone; C024964:bruceine A; C013559:holacanthone; C038607:6 alpha-senecioyloxychaparrin; D005900:Glaucarubin