An unusual sialoglycoprotein associated with the Webb-positive phenotype.
This paper presents the results of a study on the erythrocyte membrane proteins from Webb-positive individuals. The membrane proteins were separated by polyacrylamide electrophoresis and stained using a Silver stain as well as Coomassie blue and PAS stains. All Webb-positive individuals exhibited a decrease in the beta-sialoglycoprotein beta SGP band along with the appearance of a new SGP 3,000 daltons less than beta SGP. It is postulated that this band is an abnormal beta SGP possibly lacking the N-linked oligosaccharide that is normally present in beta-SGP.
D002462:Cell Membrane / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D004912:Erythrocytes / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008297:Male; D008970:Molecular Weight; D009439:Neuraminidase / Q000494:pharmacology; D010375:Pedigree; D010503:Periodic Acid-Schiff Reaction; D010641:Phenotype; D012795:Sialoglycoproteins / Q000032:analysis / Q000235:genetics*
D012795:Sialoglycoproteins; D009439:Neuraminidase