Effect of taurine administration on liver lipids in guinea pig.
The oral administration of 0.4% taurine in drinking water for 14 consecutive days showed the following hepatic effects in male guinea pig. The percentage of tauro-conjugated biliary bile acids was increased from 17.2-54.2%; the ratio liver weight/body weight was increased, and fatty change was induced. Liver triglyceride concentration was accordingly increased; diglyceride and phosphatidylcholine concentrations were reduced by the treatment, while phosphatidylethanolamine level was not affected. These changes suggest an adverse effect of taurine administration on phosphatidylcholine hepatic synthesis.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005234:Fatty Liver / Q000473:pathology; D005989:Glycerides / Q000378:metabolism; D006168:Guinea Pigs; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D013654:Taurine / Q000633:toxicity*
D005989:Glycerides; D010743:Phospholipids; D013654:Taurine