Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.
Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.
D001980:Bronchi / Q000166:cytology; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D004357:Drug Synergism; D005347:Fibroblasts / Q000187:drug effects; D005557:Formaldehyde / Q000009:adverse effects* / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008770:Methylnitrosourea / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*
D009153:Mutagens; D005557:Formaldehyde; D006147:Guanine; C008450:7-methylguanine; D008770:Methylnitrosourea; C008449:O-(6)-methylguanine