Urokinase treatment of pulmonary artery thrombosis complicating the pediatric nephrotic syndrome.
Two pediatric patients with severe pulmonary thrombosis complicating a lipoid nephrosis were treated with urokinase administered either as a continuous infusion or in massive bolus doses. Both patients recovered but one died suddenly 2 yr later after recurrence of the nephrotic syndrome and probably new massive pulmonary thrombosis. These patients had severe abnormalities of hemostasis and fibrinolysis, which favored thrombosis and complicated fibrinolytic treatment.
D002648:Child; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000503:physiopathology; D011651:Pulmonary Artery; D012008:Recurrence; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
D014568:Urokinase-Type Plasminogen Activator