title: Lidocaine depresses synaptic activity in the rat hippocampal slice.
abstract: The direct effect of the local anesthetic lidocaine was studied using the hippocampal slice preparation in order to assess the involvement of this structure in lidocaine-induced seizure activity. Changes in the evoked field potential amplitude and latency were used to measure the effect of the drug. A dose-dependent depression of the evoked field potentials was observed at lidocaine concentration of 10(-4)M and greater. No synchronized population bursting (seizures) was observed at any of the concentrations tested (10(-6)M to 10(-3)M). However, the hippocampal slice preparation is capable of producing seizure activity, as was demonstrated following application of penicillin G. The results suggest that the hippocampus is not the site of lidocaine-induced seizure activity.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
chemical_list: D008012:Lidocaine