Iron detoxification by haemoperfusion through deferoxamine-conjugated agarose-polyacrolein microsphere beads.
The natural iron chelator deferoxamine was bonded to agarose-polyacrolein microsphere beads (APAMB). This novel deferoxamine-conjugated APAMB (DCA), when used as the sorbent in a plasma/haemoperfusion system, showed specific and rapid removal of iron from plasma and blood in vitro; in vivo experiments also showed specific iron removal. The advantages of this sorbent are minimal damage to biocompounds during haemoperfusion, high capacity and specificity to iron, and the possibility of reuse.
D000171:Acrolein; D000818:Animals; D003676:Deferoxamine / Q000627:therapeutic use*; D004285:Dogs; D006464:Hemoperfusion / Q000379:methods*; D007501:Iron / Q000097:blood*; D008863:Microspheres; D011108:Polymers; D011817:Rabbits; D012685:Sepharose
D011108:Polymers; C029975:polyacrolein; D000171:Acrolein; D012685:Sepharose; D007501:Iron; D003676:Deferoxamine