title: Visual field defects in cats with neonatal or adult immunological loss of retinal ganglion cells.
abstract: Behavioral perimetry methods were used to assess the monocular visual fields of 12 cats that had received intraocular injections of antibodies against large (alpha/Y) retinal ganglion cells. The antibodies produced defects in head and eye orientation responses to stimuli presented in the nasal visual field of the treated eye; responses to stimuli in the temporal visual hemifield were normal. Similar results were seen in cats that received antibody injections at 4 weeks of age or as adults. In the context of previous results, these findings suggest that a loss of Y cells in the lateral geniculate nucleus is sufficient to reduce geniculocortical function for head and eye orientation to visual stimuli in the nasal visual field.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D055592:Biophysical Phenomena; D001703:Biophysics; D002415:Cats; D005829:Geniculate Bodies / Q000502:physiology; D007106:Immune Sera / Q000494:pharmacology; D009949:Orientation / Q000502:physiology*; D012160:Retina / Q000276:immunology* / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000276:immunology* / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology; D014794:Visual Fields; D014795:Visual Pathways / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*
chemical_list: D007106:Immune Sera