[Pupillometry in psychopharmacologic experiments].
Considering data of various clinical pharmacological studies, in which computer-assisted pupillometry was utilized, we investigated the following questions: What are the effects of drugs of 7 psychopharmacological classes on the human pupil? Do dose-efficacy and time-efficacy curves based on pupillary variables provide cues about pharmacodynamic properties of psychotropic substances? Is there a relationship between pupillometric and critical flicker frequency measures? Is there a relation between pupillometric and quantitative electroencephalographic changes? Are there correlations between static pupillometric and pharmacokinetic (e.g. blood levels) variables? Our investigations demonstrated that static pupillometry-utilized in the described manner and under certain experimental conditions - provide valuable information about effects of psychotropic drugs on the central and autonomous nervous system.
D000328:Adult; D001341:Autonomic Nervous System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography; D004585:Electrooculography; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008297:Male; D011619:Psychotropic Drugs / Q000097:blood / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects*
D011619:Psychotropic Drugs
Pupillometrie im psychopharmakologischen Experiment.