Progesterone secretion in the rat in response to an adjuvant arthritis challenge.
This study was undertaken to determine if progesterone is secreted in response to an adjuvant-induced arthritis challenge in the rat. While the arthritic rat paw volume increased 33%, the plasma progesterone concentration increased from 502 pg/ml in the control rats to 1,202 pg/ml in the arthritic animals. A strong positive correlation was found between the degree of edema and the plasma progesterone concentrations. We suggest that progesterone may play an antiinflammatory role in adjuvant arthritis in the rat.
D000818:Animals; D001168:Arthritis / Q000097:blood*; D001169:Arthritis, Experimental / Q000097:blood*; D003345:Corticosterone / Q000378:metabolism; D004487:Edema / Q000097:blood; D005528:Foot; D008297:Male; D011374:Progesterone / Q000097:blood* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011374:Progesterone; D003345:Corticosterone