title: [Flaccid paralysis following oral poliomyelitis vaccination].
abstract: This is the report of a four months old boy who developed a serous meningitis and flaccid paralysis of the left upper and lower extremity 17 days following the first immunisation with a trivalent life poliomyelitis vaccine. The patient recovered well within 2 months. Presently a mild functional disturbance and muscle wasting of the left leg can still be observed. An acute poliomyelitis can be due to a wild virus infection in an unimmunized child. Secondly an acute poliomyelitis can occur as vaccine associated poliomyelitis as it is reported in the immunocompromised host. As a third possibility the remutation of a poliomyelitis vaccine virus in a patient concomitantly infected with cytomegalovirus can be discussed. Our patient showed a normal humoral and cellular immunity. Virologic studies in our patient disclosed a wild poliomyelitis virus type III which was isolated from the stool. It cannot be clearly distinguished at the present time whether this wild virus is due to a remutation in the presence of a recent cytomegalovirus infection in our patient or due to a newly acquired wild virus infection.
mesh_terms: D002675:Child, Preschool; D006801:Humans; D008297:Male; D008581:Meningitis / Q000209:etiology; D009123:Muscle Hypotonia; D010243:Paralysis / Q000209:etiology*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects*
chemical_list: D011055:Poliovirus Vaccine, Oral
vernacular_title: Schlaffe Parese nach oraler Poliomyelitisimpfung.