Correlation between unscheduled DNA synthesis and chromosome condensation in mitoses from human lymphocytes.
The correlation between chromosome condensation and amount of repair synthesis after UV irradiation was studied in PHA-stimulated human lymphocytes. The length of selected chromosomes and the number of autoradiographic grains were determined in cells from late prophase to middle metaphase. The statistical analysis of data indicates a highly significant correlation between the two variables and a positive linear regression of the number of grains on chromosome length.
D001345:Autoradiography; D002875:Chromosomes / Q000648:ultrastructure*; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D008938:Mitosis
D004247:DNA