Effect of glucose and phloretin-2'-beta-D-glucose (phloridzin) on in vitro fertilization of mouse ova.
The fertilization ratio of mouse ova in vitro decreased when glucose concentration in the medium was lowered. However, the addition of phloretin-2'-beta-D-glucose (phloridzin), known as a glucose uptake inhibitor, restored the fertilization ratio back to the control level. The glucose moiety of the phloridzin seemed to be responsible for this effect.
D000818:Animals; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D051379:Mice; D010063:Ovum / Q000187:drug effects / Q000502:physiology*; D010695:Phlorhizin / Q000494:pharmacology*
D010695:Phlorhizin; D005947:Glucose