Gastric emptying and gastrointestinal absorption of alcohol ingested with a meal.
We have measured, by an intubation method, gastric evacuation and gastrointestinal absorption of alcohol ingested with a meal in seven healthy nonalcoholic subjects. A homogenized meal containing [14C]PEG and ethanol (1 g/kg body wt) was given intragastrically while saline containing [57CO]vitamin B12 was perfused into the duodenum. Of the ingested alcohol, 39.4 +/- 4.1% was absorbed through the stomach wall during the first postprandial hour and 73.2 +/- 4.2% during the total postcibal period, whereas only 24 +/- 3% was absorbed during the same time in the duodenum. Thus alcohol ingested with a meal is mainly and rapidly absorbed in the stomach; the contribution of the small intestine below the angle of Treitz to alcohol absorption is negligible.
D000328:Adult; D002250:Carbon Radioisotopes; D003037:Cobalt Radioisotopes; D004386:Duodenum / Q000378:metabolism; D000431:Ethanol / Q000097:blood / Q000378:metabolism*; D005502:Food; D005746:Gastric Emptying; D005753:Gastric Mucosa / Q000378:metabolism; D005766:Gastrointestinal Contents; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols; D011708:Pylorus / Q000502:physiology; D014805:Vitamin B 12
D002250:Carbon Radioisotopes; D003037:Cobalt Radioisotopes; D000431:Ethanol; D011092:Polyethylene Glycols; D014805:Vitamin B 12