Reactivators of organophosphorus-inhibited acetylcholinesterase. 1. Imidazole oxime derivatives.
4-[(Hydroxyimino)methyl]-3-methylimidazolium iodides were prepared and tested for their reactivating potency on acetylcholinesterase inhibited by tetraethyl pyrophosphate (TEPP). The in vitro testing revealed that the new compounds are weak reactivators of the phosphorylated electrophorus acetylcholinesterase.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D004593:Electrophorus; D004789:Enzyme Activation; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010766:Phosphorylation
D007093:Imidazoles; D000110:Acetylcholinesterase