Inhibition of IgE antibody formation by n-pentyl alpha-L-sorbopyranoside.
Effect of n-pentyl glycosides and alkyl alpha-L-sorbopyranosides on IgE antibody formation in rats and mice were investigated. When n-pentyl alpha-L-sorbopyranoside was given subcutaneously or orally, the IgE antibody formation in rats and mice was suppressed, while no suppression of hemagglutinin formation was observed. The study on timing of administration indicated that n-pentyl alpha-L-sorbopyranoside significantly suppressed the secondary IgE antibody response when administered before the secondary immunization.
D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D005260:Female; D006388:Hemagglutinins / Q000096:biosynthesis; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains; D013013:Sorbose / Q000031:analogs & derivatives* / Q000494:pharmacology
D006388:Hemagglutinins; D007166:Immunosuppressive Agents; D007073:Immunoglobulin E; C048508:n-pentylsorbopyranoside; D013013:Sorbose