title: [Results of the clinical use of 75Se-methionine in gastroenterology with different modes of administration].
abstract: Gamma-topography of the abdominal region and radiometry of duodenal aspirates were used for examination of 707 patients with different gastroenterological pathology using various modes of the administration of 75Se-methionine (intravenously, per os, into the duodenal and cecal lumens, intra-arterially in the celiac trunk and superior mesenteric artery). The RP administered intravenously was accumulated in health in the liver and pancreas. The drug fixation by the proximal part of the jejunum was also typical of chronic pancreatitis, the degree of fixation being well correlated with a period of disease. A jejunum image on gamma-topograms proved to be determined not by radioactivity of the jejunum in passage of labeled pancreatic juice but by extraction of the radionuclide from the blood by its wall. In transduodenal administration of the radionuclide its major part was rapidly absorbed and accumulated in the liver. At the same time a considerable part of the drug remained at the site of administration and retained there for several days. There was almost no absorption of the drug in the cecum and ascending colon. Like in the duodenum, the drug retained at the site of administration for a long time. Intestinal extravasal trophicity was assumed.
mesh_terms: D000284:Administration, Oral; D002432:Cecum; D004066:Digestive System Diseases / Q000000981:diagnostic imaging*; D004386:Duodenum; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D011877:Radionuclide Imaging; D012643:Selenium / Q000008:administration & dosage*; D012645:Selenomethionine / Q000008:administration & dosage*
chemical_list: D012645:Selenomethionine; D012643:Selenium
vernacular_title: Rezul'taty klinicheskogo primeneniia 75Se-metionina v gastroénterologii pri raznykh sposobakh vvedeniia preparata.