[Pharmacokinetics of a water-soluble antioxidant from the class of 3-hydroxypyridines].
The study of pharmacokinetics of water-soluble 2-ethyl-6-methyl-3-hydroxypyridine salt (EM-3-HP) in rats has shown this substance to be quickly absorbed from the abdominal cavity of animals. Its maximal concentrations in the plasma, brain and liver were determined 2-3 hours later, with the following monoexponential decrease in EM-3-HP level with the elimination half-life of 2-6 hours observed. Considerable EM-3-HP tropism to membranes of endoplasmic reticulum in the liver and brain cells is suggested to cause its membranomodulatory effect and to facilitate its pharmacological activity.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010847:Picolines / Q000378:metabolism*; D051381:Rats; D012995:Solubility; D013997:Time Factors; D014018:Tissue Distribution
D000975:Antioxidants; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine
Farmakokinetika vodorstvorimogo antioksidanta iz klassa 3-oksipiridinov.