The effect of various drugs on canine ureteric peristalsis.
Using an intact concious animal model the effect of various drugs on the rate of canine ureteric peristalsis was studied. The drugs found to reduce consistently the rate of ureteric peristalsis were diazoxide, terbutaline, and ritodrine. Ritodrine was the most consistent, having a prolonged effect and reducing the rate of ureteric peristalsis to 50% of the rates observed in control experiments.
D000818:Animals; D003085:Colic / Q000188:drug therapy; D003981:Diazoxide / Q000494:pharmacology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D009119:Muscle Contraction / Q000187:drug effects; D012312:Ritodrine / Q000494:pharmacology; D013726:Terbutaline / Q000494:pharmacology; D014513:Ureter / Q000187:drug effects* / Q000502:physiology; D014515:Ureteral Diseases / Q000188:drug therapy; D014700:Verapamil / Q000494:pharmacology
D014700:Verapamil; D012312:Ritodrine; D013726:Terbutaline; D003981:Diazoxide