[Circadian fluctuations in dioxidine toxicity].
It has been established in rat experiments that toxicity of the antibacterial drug dioxydin (1,4-di-N-oxide 2,3-dioxymethylquinoxaline) depends on the time of administration. The drug exhibits the minimal and maximal toxicity upon administration at 8 o'clock p.m. and at 12 o'clock, respectively.
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D005938:Glucocorticoids / Q000097:blood; D008297:Male; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D000890:Anti-Infective Agents; D005938:Glucocorticoids; D011810:Quinoxalines; C001077:dioxidine
Sutochnye kolebaniia toksichnosti dioksidina.