Clonal heterogeneity in a case of Merkel cell carcinoma demonstrated by flow cytometry.
A 66-year-old female patient is presented in whom a rapidly growing tumour developed on the glabella. Light and electron microscopy confirmed Merkel cell carcinoma. Flow cytometry (FCM), performed of a tumour specimen, yielded multiple aneuploid stem lines. The FCM data are discussed with regard to the histological features and the biological behaviour of the tumour.
D000368:Aged; D002277:Carcinoma / Q000235:genetics* / Q000648:ultrastructure; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D012878:Skin Neoplasms / Q000235:genetics* / Q000648:ultrastructure