[Benzylidene-5 pyrrolones, furanones and thiophenones. 2. Quantitative structure-activity relationship].
Quantitative structure-activity relationships (QSAR) have been derived for twenty two 5-benzylidene furanones, pyrrolones and thiophenones having antifungal activity against Candida albicans. The correlation with the parabolic (Hansch) or bilinear (McFarland-Kubinyi) models are superior to those with the linear models (Free-Wilson or Fujita-Ban), while no significant differences exist between the parabolic and bilinear models. Lipophilicity was necessary for good in vitro activity of these compounds.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D001597:Benzylidene Compounds; D005663:Furans; D011758:Pyrroles; D013876:Thiophenes
Benzylidène-5 pyrrolones, furanones et thiophénones. II. Corrélation structure activité antifongique quantitative.