Cells from patients with ataxia telangiectasia are abnormally sensitive to the cytotoxic effect of a tumor promoter, phorbol-12-myristate-13-acetate.
Fibroblast strains from 6 patients with ataxia telangiectasia (A-T) were found to be markedly hypersensitive to the cytotoxic action of the tumor promoter phorbol-12-myristate-13-acetate (PMA), their D37 values being 5 times lower than those of two normal controls. Two A-T heterozygous strains were slightly hypersensitive to PMA, while a third one showed normal sensitivity. It is concluded that the DNA lesion which is critical in A-T cells is an important component of the damage caused by PMA-induced free radicals and may play a role both in the tumor-promoting activity of PMA and the cancer proneness of A-T patients.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects; D006579:Heterozygote; D006801:Humans; D010704:Phorbols / Q000633:toxicity*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*
D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate