Synthesis and properties of 3-aminomethyl derivatives of 3H-2-imino-7-methyl-4-oxopyrido-[3,2-e]-1,3-thiazine-5- and -6-carboxylic acids.
It was stated that esters of 3H-2-imino-7-methyl-4-oxopyrido [3,2-e]-1,3-thiazine-5- and -6-carboxylic acids (I, II) undergo the Mannich reaction giving the corresponding 3-aminomethyl derivatives (III-XIV). Derivatives of ester II [(XII) and (XIV)] showed distinct analgesic and antiserotonic activities.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D000927:Anticonvulsants / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists / Q000138:chemical synthesis*; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D002264:Carboxylic Acids; D011725:Pyridines; D012702:Serotonin Antagonists; D013843:Thiazines; D012110:Reserpine; D006591:Hexobarbital