Urinary excretion of benzidine in relation to the acetylator status of occupationally exposed subjects.
Twenty-four male workers engaged in the manufacture of benzidine dihydrochloride for 1-4 years were included in this study. Urinary levels of free benzidine were estimated by high-pressure liquid chromatography in all the workers. Acetylator status of the workers was determined with sulphamethazine. There was substantial absorption of benzidine over an 8-h work shift. A significant correlation was observed between the rate of sulphamethazine acetylation and urinary excretion of free benzidine.
D000107:Acetylation; D000328:Adult; D001560:Benzidines / Q000652:urine*; D002617:Chemical Industry; D004781:Environmental Exposure; D006417:Hematuria / Q000652:urine; D006801:Humans; D008297:Male; D013418:Sulfamethazine / Q000097:blood; D014556:Urine / Q000166:cytology
D001560:Benzidines; C029876:benzidine; D013418:Sulfamethazine