Scanning electron microscopical study of the effects of crystalloid and water-soluble glucocorticoids on articular cartilage.
A comparative scanning electron microscopical study on the topical effects of glucocorticoids on rat knee cartilage was undertaken. Water-soluble and crystalloid 'depot'-form glucocorticoids were tested. Cartilage destruction was dependent on the number of injections and was clearly more pronounced in the knees injected with crystalloid glucocorticoid. We conclude that repeated injection of the joint with glucocorticoids should be given only after careful consideration of the clinical state.
D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects* / Q000648:ultrastructure; D003460:Crystallization; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility
D006854:Hydrocortisone; D008775:Methylprednisolone