title: Salicylate toxicity.
abstract: Understanding of the pharmacologic principles and the pathogenesis of salicylate toxicity provides a basis for the optimization of clinical management. The role of salicylate as a scientifically proven cause of Reye's syndrome remains controversial despite epidemiologic data. The management guidelines discussed illustrate treatment details based on the pathophysiology of salicylate toxicity.
mesh_terms: D000042:Absorption; D000138:Acidosis / Q000139:chemically induced; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects; D002606:Charcoal / Q000627:therapeutic use; D002675:Child, Preschool; D005440:Fluid Therapy; D005751:Gastric Lavage; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007003:Hypoglycemia / Q000139:chemically induced; D007223:Infant; D007700:Kinetics; D009325:Nausea / Q000139:chemically induced; D012125:Respiratory Center / Q000187:drug effects; D012202:Reye Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D012459:Salicylates / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism
chemical_list: D012459:Salicylates; D002606:Charcoal; D005947:Glucose