Depressed plasma pyridoxal-5'-phosphate levels in tobacco-smoking men.
Tobacco-smoking men (n = 106) showed considerably lower plasma pyridoxal-5'-phosphate levels (P less than 0.001) than non-smoking controls (n = 143). A previously reported inverse relationship between plasma pyridoxal-5'-phosphate levels and age is confirmed by using new and sensitive high-performance liquid chromatography methodology for pyridoxal-5'-phosphate determinations. Plasma pyridoxal levels were neither lower in tobacco-smoking men nor could any relationship between pyridoxal levels and age be demonstrated. Two major risk factors for coronary artery disease, tobacco-smoking and increasing age, are thus associated with lower plasma pyridoxal-5'-phosphate levels.
D000328:Adult; D000367:Age Factors; D001161:Arteriosclerosis / Q000209:etiology; D003327:Coronary Disease / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011730:Pyridoxal / Q000097:blood; D011732:Pyridoxal Phosphate / Q000097:blood*; D012306:Risk; D012907:Smoking
D011730:Pyridoxal; D011732:Pyridoxal Phosphate