Attempt to fulfil Koch's postulates for pyloric Campylobacter.
A volunteer with histologically normal gastric mucosa received pyloric campylobacter by mouth. A mild illness developed, which lasted 14 days. Histologically proven gastritis was present on the tenth day after the ingestion of bacteria, but this had largely resolved by the fourteenth day. The syndrome of acute pyloric campylobacter gastritis is described. It is proposed that this disorder may progress to a chronic infection which predisposes to peptic ulceration.
D000126:Achlorhydria / Q000209:etiology; D000208:Acute Disease; D000328:Adult; D001706:Biopsy; D002167:Campylobacter / Q000472:pathogenicity; D002169:Campylobacter Infections / Q000188:drug therapy / Q000382:microbiology; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D014011:Tinidazole / Q000627:therapeutic use
D014011:Tinidazole