title: Pustular contact hypersensitivity to fluorouracil with rosacealike sequelae.
abstract: A 51-year-old woman had a severe pustular contact hypersensitivity reaction to fluorouracil used to treat actinic keratoses on the face. The reaction was composed of long-lasting redness, facial flushing, exaggerated skin markings, and sensory changes. Physicians prescribing topical fluorouracil should be aware of its potential to produce such a severe reaction.
mesh_terms: D000287:Administration, Topical; D003877:Dermatitis, Contact / Q000209:etiology* / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000209:etiology* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology
chemical_list: D005472:Fluorouracil