Apo E-mediated uptake and degradation of normal very low density lipoproteins by human monocyte/macrophages: a saturable pathway distinct from the LDL receptor.
Normal human fasting very low density lipoproteins (n-VLDL; d less than 1.006 g/ml) were demonstrated to be taken up and degraded by human monocyte-macrophages via a saturable process distinct from the previously described LDL and scavenger receptors. Through the use of apolipoprotein-phospholipid complexes, apolipoprotein E (apoE) was identified as the ligand mediating recognition of n-VLDL by this receptor.
D001057:Apolipoproteins E / Q000378:metabolism*; D005215:Fasting; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008954:Models, Biological; D009000:Monocytes / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism*
D001057:Apolipoproteins E; D008079:Lipoproteins, VLDL; D011973:Receptors, LDL