Renal effects of aluminium in uraemic rats and in rats with intact kidney function.
The effect on renal function following administration of aluminium (i.p., five times weekly (0.05 or 0.5 mg kg-1 body weight) for 12 weeks) to partially nephrectomized (5/6 NX) or intact female rats was examined. The observed loss of concentrating ability, characterized by increased urine volume and an increased sodium excretion, as well as increased renal excretion of p-aminohippurate (demonstrable after low-dose treatment with nephrotoxins) can be interpreted as an initiation of kidney function injury. No distinct differences in response were observed between partially nephrectomized and intact animals.
D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001835:Body Weight; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D009392:Nephrectomy; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D014511:Uremia / Q000503:physiopathology* / Q000652:urine; D010130:p-Aminohippuric Acid
D012964:Sodium; D000535:Aluminum; D011188:Potassium; D010130:p-Aminohippuric Acid