[Effect of naphthoquinones and tocopherols on the changes in mitochondrial volume].
Experiments with albino mice show that a long deficiency of natural tocopherols and naphthoquinones in the organism causes a change in the mitochondrial volume of the liver, myocardium and skeletal muscles. Addition of ADP (5 mM) to the mitochondrial suspension does not lead to adequate changes in the optic density that evidences for inability of mitochondria to regulate actively their volume under a long K- and E-hypovitaminosis. Due to the treatment of intact mitochondria with 1% acetone solution the volume of mitochondria changes significantly, whereas addition of vitamin KI (2-4 mM) prevents partially these changes.
D000818:Animals; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism; D009285:Naphthoquinones / Q000494:pharmacology*; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology
D009285:Naphthoquinones; D014812:Vitamin K; D014810:Vitamin E
Vliianie naftokhinonov i tokoferolov na izmenenie ob''ema mitokhondriĭ.