Small intestinal adenocarcinoma complicating regional enteritis.
Three new cases of small intestinal adenocarcinoma complicating Crohn's disease are reported. Seventy-five other cases have been reported to date. Analysis of these cases in comparison with de novo adenocarcinoma of the small bowel shows that they: (1) occur at a younger age; (2) occur in distal small bowel; (3) show a male predilection; and (4) have a worse prognosis. The increasing number of these cases suggests that small intestinal regional enteritis predisposes to adenocarcinoma. Improved prognosis can only be achieved with earlier diagnosis.
D000230:Adenocarcinoma / Q000209:etiology* / Q000601:surgery; D000231:Adenocarcinoma, Papillary / Q000209:etiology / Q000601:surgery; D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000209:etiology* / Q000601:surgery; D007580:Jejunal Neoplasms / Q000209:etiology* / Q000601:surgery; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D011379:Prognosis