title: Endogenous splenic colonies and megakaryopoiesis in methylcellulose treated irradiated mice.
abstract: Endogenous splenic colonies are increased in methylcellulose-treated irradiated mice, 10 days after sublethal irradiation (450 R). The spleen shows an enhancement of megakaryopoiesis, especially localized around foam-cell foci. This suggests that the macrophage system, activated through phagocytic activity against methylcellulose, affects megakaryopoiesis by a microenvironmental mechanism.
mesh_terms: D000818:Animals; D005487:Foam Cells / Q000166:cytology; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D008264:Macrophages / Q000502:physiology; D008297:Male; D008533:Megakaryocytes / Q000166:cytology*; D008747:Methylcellulose / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*
chemical_list: D008747:Methylcellulose