Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells.
Cytotoxicity, chromosome aberrations, and mutations to 6-thioguanine resistance were synergistically increased by incubating the ultraviolet light (UV)-irradiated Chinese hamster ovary (CHO) cells in medium containing sodium arsenite. However, the frequencies of sister-chromatid exchanges and mutations to ouabain resistance induced by UV were not synergistically increased by sodium arsenite. The synergistic effect of sodium arsenite on UV-induced chromosome aberrations varied with cell-harvesting time and decreased with increasing time intervals between UV and sodium arsenite treatments.
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D018053:Arsenites; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005260:Female; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D010042:Ouabain / Q000494:pharmacology; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects; D013866:Thioguanine / Q000494:pharmacology; D014466:Ultraviolet Rays
D018053:Arsenites; D010042:Ouabain; D013866:Thioguanine; C015001:arsenite; D001151:Arsenic