Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan.
The combination of monoamine oxidase inhibitors and tryptophan--a recognized antidepressant regimen--has been reported to cause behavioral or neurologic toxicity. The authors present eight cases of delirious syndromes apparently attributable to this combination of agents.
D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy; D003693:Delirium / Q000139:chemically induced*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006963:Hyperphagia / Q000188:drug therapy; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects*; D009207:Myoclonus / Q000139:chemically induced; D010624:Phenelzine / Q000009:adverse effects; D014191:Tranylcypromine / Q000009:adverse effects; D014364:Tryptophan / Q000009:adverse effects*
D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D014364:Tryptophan; D010624:Phenelzine