Vitamin C intoxication and hyperoxalemia in chronic hemodialysis patients.
We studied vitamin C levels in 25 stable patients on chronic hemodialysis who were taking 0.5-1 g vitamin C orally daily and/or dialyzed against dialysate containing 33.3 micrograms/ml of vitamin C. We also studied the relationship between serum vitamin C and oxalate levels in 7 patients on chronic hemodialysis. All patients had markedly elevated pre- and postdialysis levels of vitamin C. The predialysis levels of vitamin C showed extremely good correlation to the serum oxalate levels. Overingestion of vitamin C in food or as supplementation may lead to excessive serum levels of vitamin C, resulting in hyperoxalemia that may contribute to vascular disease in patients on chronic hemodialysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000378:metabolism / Q000506:poisoning*; D002648:Child; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008875:Middle Aged; D010070:Oxalates / Q000097:blood*; D019815:Oxalic Acid; D006435:Renal Dialysis
D010070:Oxalates; D019815:Oxalic Acid; D001205:Ascorbic Acid