title: Monozygotic twins non-concordant for oligomeganephronic renal hypoplasia: artery-vein placental shunting as a possible pathogenetic mechanism.
abstract: The etiology and pathogenesis of oligomeganephronic renal hypoplasia (OMN) are not known. In the present paper a second case of monozygotic twins non-concordant for OMN is described. It is hypothesized that one of the mechanisms which have been proposed to explain structural defects in monozygotic twins, namely placental artery-vein shunting, may have been involved in the pathogenesis of OMN in these patients. In OMN in general vascular abnormalities may have to be considered as a pathogenetic mechanism.
mesh_terms: D001706:Biopsy; D002648:Child; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000235:genetics*; D009399:Nephrons / Q000002:abnormalities; D014430:Twins, Monozygotic