Pyrimidine deoxyribonucleotide metabolism in Acholeplasma laidlawii B-PG9.
Extracts of Acholeplasma laidlawii B-PG9 were examined for the enzymes associated with the interconversion of the pyrimidine deoxyribonucleotides and the biosynthesis of thymidine nucleotides. A. laidlawii B-PG9 possessed deaminases for deoxycytidine and dCMP, pyrophosphatases for dUTP, phosphorylases for thymidine and uridine, and a membrane-associated pyrimidine deoxyribonucleoside monophosphate phosphatase activity. The role these enzyme activities have in the generation of deoxyribose-1-phosphate during growth may explain the ability of A. laidlawii B-PG9 to utilize either thymine or thymidine for biosynthesis.
D000128:Acholeplasma laidlawii / Q000201:enzymology / Q000378:metabolism*; D002462:Cell Membrane / Q000201:enzymology; D003593:Cytoplasm / Q000201:enzymology; D011742:Pyrimidine Nucleotides / Q000378:metabolism*; D012267:Ribosemonophosphates / Q000378:metabolism; D013942:Thymine Nucleotides / Q000096:biosynthesis
D011742:Pyrimidine Nucleotides; D012267:Ribosemonophosphates; D013942:Thymine Nucleotides; C031302:2-deoxyribose 1-phosphate