Human seminal antiliquefying agents--a potential approach towards vaginal contraception.
One-hundred-one natural and synthetic enzyme inhibitors or inactivators were screened in vitro against the liquefaction property of human ejaculates with a view to develop antiliquefying agents for vaginal contraception. Of those compounds, 27 demonstrated no effect, 36 quickened and 20 delayed the process of liquefaction, while 18 agents stopped it completely. The highly effective antiliquefying agents also showed spermicidal property and were found to coagulate even the liquid ejaculates. Compounds having antiliquefying property, together with coagulating and spermicidal activities, will offer a highly promising approach towards vaginal contraception.
D003270:Contraceptive Agents; D004542:Ejaculation; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D012661:Semen / Q000187:drug effects*; D013081:Sperm Motility / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014621:Vagina
D003270:Contraceptive Agents; D004791:Enzyme Inhibitors