Release of cholecystokinin-immunoreactivity into the vascular bed of the guinea-pig small intestine during peristalsis.
The release of cholecystokinin-immunoreactivity (CCK-IR) into the venous effluate of the isolated and vascularly perfused guinea-pig small intestine was measured. Raising the intraluminal pressure by 5 mbar for 8 min initiated peristalsis and was associated with an increased release of CCK-IR. The ganglion stimulant dimethylphenyl-piperazinium failed to alter the release of CCK-IR. The results are discussed in the light of a possible involvement of CCK-containing neurones in intestinal peristalsis.
D000818:Animals; D002766:Cholecystokinin / Q000276:immunology / Q000378:metabolism*; D005769:Gastrointestinal Motility; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000098:blood supply / Q000378:metabolism*; D010528:Peristalsis
D002766:Cholecystokinin