[TPA enhancement of the mutagenic and transforming action of bovine adenovirus type 3 on cultured mouse cells].
The cultured 10TI/2C3H mouse cells were infected with bovine adenovirus 3(BAV-3) and treated by TPA. This combined treatment induced ouabain-resistant mutants 19 to 26 times more often than action of only BAV-3. BAV-3- and TPA-treated cells were implanted to syngenic mice. The tumours appeared 10 times more often than in the mice after implantation of only adenovirus treated cells.
D000256:Adenoviridae / Q000187:drug effects / Q000472:pathogenicity*; D000818:Animals; D002417:Cattle; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D051379:Mice; D008809:Mice, Inbred C3H; D009154:Mutation; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000209:etiology; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate
Usilenie s pomoshch'iu TFA mutagennogo i transformiruiushchego deĭstviia bych'ego adenovirusa tipa 3 na kul'tiviruemye kletki myshi.