Inhibition of pancreatic exocrine secretion and bile entry into the duodenum by isometheptene, a sympathomimetic agent.
We have studied the effect of isometheptene, an indirectly acting sympathomimetic with analgesic and antispastic properties, on secretin-cholecystokinin-stimulated pancreatic and biliary outputs. Isometheptene, infused intravenously at a dose of 100 mg in 30 min, significantly inhibited bicarbonate, enzyme, and bilirubin output in eight healthy subjects (compared to control values, the maximum percent inhibition was 34% for bicarbonate, 57% for lipase, 61% for chymotrypsin, and 86% for bilirubin). In four cholecystectomized subjects, the drug inhibited only pancreatic outputs. The inhibitory effect on pancreatic secretion, coupled with the analgesic action, suggest a potential benefit of this drug in acute pancreatic pathology.
D000328:Adult; D001646:Bile / Q000502:physiology*; D001663:Bilirubin / Q000096:biosynthesis; D002918:Chymotrypsin / Q000096:biosynthesis; D004386:Duodenum / Q000032:analysis*; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007419:Intestinal Secretions / Q000032:analysis*; D008049:Lipase / Q000096:biosynthesis; D008297:Male; D008744:Methylamines / Q000494:pharmacology*; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*
D008744:Methylamines; D013566:Sympathomimetics; D008049:Lipase; D002918:Chymotrypsin; D001663:Bilirubin; C008192:isometheptene