title: Mitogenic effects of sera from normal and psoriatic subjects on human skin fibroblasts.
abstract: Sera from normal and psoriatic subjects had similar mitogenic effects when added to monolayer cultures of human skin fibroblasts. Fibroblasts derived from a psoriasis patient proliferated faster in both types of sera than fibroblasts from a normal subject, despite similar rates of proliferation in foetal calf serum. The psoriatic fibroblasts appeared to be inherently capable of a greater response to human serum mitogens than the normal fibroblasts.
mesh_terms: D002455:Cell Division; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008934:Mitogens / Q000097:blood*; D011565:Psoriasis / Q000097:blood*; D012867:Skin / Q000166:cytology*
chemical_list: D008934:Mitogens