title: Consequences of candidemia for pediatric patients.
abstract: The hospital records of 45 infants and children with one or more blood cultures positive for Candida species were studied retrospectively in an attempt to define the risk of Candida-related complications. Death of eight of the patients (18%) was related to Candida infection, and five additional patients (11%) had metastatic foci of infection but survived. No characteristics were identified that would predict patients who were at high risk for complications of candidemia. Eleven patients were treated with amphotericin B for longer than a week and were examined for evidence of nephrotoxicity. None had persistent abnormalities of blood urea nitrogen or serum creatinine concentrations develop during treatment; two patients had hypokalemia.
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use*; D001769:Blood / Q000382:microbiology; D001806:Blood Urea Nitrogen; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced / Q000188:drug therapy; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D012189:Retrospective Studies
chemical_list: D000666:Amphotericin B; D003404:Creatinine; D005437:Flucytosine