Pharmacokinetics of flunixin meglumine in dogs.
The pharmacokinetics of flunixin meglumine, a potent nonsteroidal anti-inflammatory agent, were studied in 6 intact, awake dogs. Plasma samples were obtained up to 12 hours after IV administration of flunixin meglumine. Flunixin concentration was determined, using high performance liquid chromatography. Plasma data best fit a 2-compartment model. Distribution half-life was 0.55 hour; elimination half-life was 3.7 hours; volume of distribution (area) was 0.35 L/kg; volume of distribution at steady state was 0.18 L/kg; volume of the central compartment was 0.079 L/kg; and total body clearance was 0.064 L/hr/kg. Flunixin concentrations obtained over a 6-hour period in 3 dogs with septic peritonitis did not differ significantly from those obtained from healthy dogs.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism; D004285:Dogs / Q000378:metabolism*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007700:Kinetics; D009539:Nicotinic Acids / Q000378:metabolism*; D010538:Peritonitis / Q000378:metabolism / Q000662:veterinary; D013997:Time Factors
D009539:Nicotinic Acids; C014558:flunixin meglumine; D003002:Clonixin