[Acid phosphatase distribution in the liver in cirrhosis].
The distribution of acid phosphatase in liver cirrhosis, as well as in its reverse development, was investigated in mice using histochemistry and electron histochemistry methods. Histochemistry demonstrated a sharp activity increase of acid phosphatase (as compared with the same in the material of partial hepatectomy) in liver cells (especially hepatocytes) during liver cirrhosis regression 10 days after a partial hepatectomy. Electron histochemistry has shown the enzyme withdraw out of hepatocytes and connective tissue cells of fibrotic stratum in the extra-cell medium. The reaction product localized on the neighbouring collagen fibres giving evidence that during reverse development of liver cirrhosis the lisosomal enzyme release from specified cells by means of exocytosis and they are involved in the lysis of collagen.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D006498:Hepatectomy; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000201:enzymology; D008115:Liver Regeneration; D008247:Lysosomes / Q000201:enzymology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D013997:Time Factors
D000135:Acid Phosphatase
Raspredelenie kisloĭ fosfatazy v pecheni pri tsirroze.