title: Effect of left-to-right, mixed left-to-right, and right-to-left shunts on inhalational anesthetic induction in children: a computer model.
abstract: We describe a seven-compartment physiologic model of inhalational anesthetic induction with circulatory shunts that was used to simulate inhalational anesthetic induction in children with congenital heart disease. Our conclusions based on this model are that left-to-right (L-R) shunting has little effect on speed of induction; right-to-left (R-L) shunting significantly slows induction of N2O and halothane anesthesia; and adding an L-R shunt to a preexisting R-L shunt will attenuate the slowing of induction caused by the R-L shunt.
mesh_terms: D000769:Anesthesia, Inhalation; D001166:Arteriovenous Shunt, Surgical; D002560:Cerebrovascular Circulation; D002648:Child; D003201:Computers; D004986:Ether; D006221:Halothane; D006439:Hemodynamics; D006801:Humans; D008954:Models, Biological; D009589:Nitrogen Oxides; D010313:Partial Pressure; D011652:Pulmonary Circulation; D012119:Respiration
chemical_list: D009589:Nitrogen Oxides; D004986:Ether; D006221:Halothane