Cell growth and cell division: dissociated and random initiated? A study performed on embryonal carcinoma cell lines. II.
The 'random transition probability' cell-cycle models have so far failed to convincingly link the transition events with phenomena describable by biochemical methods. The study presented was carried out on the F9 and PCC3 N/1 embryonal carcinoma (EC) cell lines. We now report an extended analysis of the two-random transition probability (TP) model and preliminary results are presented showing that the deterministic L period in that model can be regarded as reflecting the 'cell-growth cycle'. Evidence is presented that suggests that the 'cell-growth cycle' is a supramitotic deterministic phase--i.e. starting in one cell cycle and being completed in the next following G1 period and dissociated from the 'DNA-division cycle'. This phenomenon makes an interesting contribution to the old knowledge of a stepwise G1 prolongation during early embryogenesis in yielding a mechanism by which the cell can alter the ratio of nucleus to cytoplasm prior to the onset of gene expression.
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D004247:DNA / Q000032:analysis; D054278:Embryonal Carcinoma Stem Cells; D007399:Interphase; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism; D011336:Probability; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis
D011506:Proteins; D004247:DNA