Induction and detection of a third isometallothionein (metallothionein-II') in rat liver.
A third isometallothionein was shown to be present during metallothionein synthesis, particularly following induction by zinc (Zn). It appeared to be closely related to metallothionein-II and the relative amount decreased with time, with only a minor peak after repeated cadmium (Cd) loading. On-line column switching by high-performance liquid chromatography (HPLC)-atomic absorption spectrophotometry (AAS) is effective in analysing and characterizing isometallothioneins.
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008668:Metallothionein / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000494:pharmacology
D008668:Metallothionein; D015032:Zinc