IgA nephropathy associated with disseminated tuberculosis.
A 59-year-old man had disseminated tuberculosis and microscopic hematuria, red cell casts, and normal renal function. Renal biopsy revealed focal mesangial proliferation with exclusively IgA deposits, diagnostic of IgA nephropathy. After institution of antituberculous therapy, the urinary abnormalities resolved. There is evidence to suggest that tuberculosis, in addition to other conditions associated with mucosal exposure to antigens producing an IgA immune response, can result in IgA nephropathy. This glomerulopathy is reported as a potential renal complication of concurrent mycobacterial infection.
D005921:Glomerulonephritis / Q000209:etiology*; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000276:immunology; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000276:immunology
D007070:Immunoglobulin A