The effect of glucagon and glucagon 1-21 on anal sphincter function.
Resting anal sphincter pressure and rectoanal reflex were studied in six healthy volunteers after administration of placebo, glucagon, and glucagon 1-21. Glucagon resulted in a marked but short-lived early decrease in resting anal pressure, whereas the 1-21 fragment of the glucagon molecule had no effect. Further investigation of the possible hormonal/peptidergic regulation of anal sphincter function is necessary.
D001003:Anal Canal / Q000187:drug effects* / Q000502:physiology; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology*; D011312:Pressure; D012018:Reflex / Q000187:drug effects; D013997:Time Factors
D010446:Peptide Fragments; C043386:glucagon (1-21); D005934:Glucagon