Pattern of CNS recovery following reversal of neuromuscular blockade. Comparison of atropine and glycopyrrolate.
Recovery from anaesthesia was compared, in a group of patients (n = 25) receiving a mixture of glycopyrrolate and neostigmine (to reverse non-depolarizing neuromuscular blockade), with recovery in a group of patients (n = 25) receiving an atropine-neostigmine mixture. Recovery following anaesthesia was more rapid in the patients receiving the glycopyrrolate-neostigmine mixture.
D000328:Adult; D001285:Atropine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D009892:Opium / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy; D010197:Pancuronium / Q000037:antagonists & inhibitors; D011759:Pyrrolidines / Q000494:pharmacology*; D013390:Succinylcholine / Q000037:antagonists & inhibitors; D013997:Time Factors
D011759:Pyrrolidines; D009388:Neostigmine; D001285:Atropine; D009892:Opium; D013390:Succinylcholine; D010197:Pancuronium; D006024:Glycopyrrolate