Experimental intravitreal 5-fluorocytosine.
The pyrimidine 5-fluorocytosine is a water soluble agent which may be suitable for intravitreal injection in the treatment of Candida endophthalmitis. Experimental ocular toxicity studies of intravitreal 5-fluorocytosine have been performed in rabbits with the aid of slit-lamp biomicroscopy, indirect ophthalmoscopy, electroretinography, and histologic examination. Intravitreal injection of 100 micrograms 5-fluorocytosine produced no detectable ocular injury.
D000818:Animals; D002177:Candidiasis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D004596:Electroretinography; D005437:Flucytosine / Q000009:adverse effects / Q000627:therapeutic use*; D007267:Injections; D009916:Orbital Diseases / Q000188:drug therapy*; D010786:Photoreceptor Cells / Q000187:drug effects; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D014822:Vitreous Body
D003596:Cytosine; D005437:Flucytosine