Naloxone-induced dissociation of oxytocin and prolactin releases.
Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT release was observed. These results demonstrate that concomitant releases of OT and PRL in response to a given physiologic stimulus (stress) can be dissociated and suggest that the hypothalamic events which are responsible for the release of these hormones during stress are different.
D000818:Animals; D004298:Dopamine / Q000502:physiology; D004723:Endorphins / Q000502:physiology*; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010121:Oxytocin / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
D004723:Endorphins; D009270:Naloxone; D010121:Oxytocin; D011388:Prolactin; D004298:Dopamine