Cocaine and phencyclidine. Heterogenous dopaminergic interactions with tetrabenazine.
The present study investigated the actions of cocaine, phencyclidine and amfonelic acid upon the formation and release of dopamine in synaptosomes in the brain of the rat in the presence of tetrabenazine and reserpine. The results suggest that these three stimulants may act upon selective intraneuronal vesicles, heterogeneously associated with the formation of dopamine from phenylalanine and tyrosine.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D066298:In Vitro Techniques; D008928:Mitochondria / Q000187:drug effects; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology; D013574:Synaptosomes / Q000187:drug effects; D013747:Tetrabenazine / Q000494:pharmacology*; D014443:Tyrosine / Q000378:metabolism
D009287:Naphthyridines; D011954:Receptors, Dopamine; D009268:Nalidixic Acid; D014443:Tyrosine; D010649:Phenylalanine; D012110:Reserpine; D000661:Amphetamine; D003042:Cocaine; D010622:Phencyclidine; C006486:amfonelic acid; D004298:Dopamine; D013747:Tetrabenazine