title: The influence of diuretics on the excretion and metabolism of doping agents. II. Phentermine.
abstract: The urinary excretion of phentermine in humans was followed over a period of several days after the oral administration of two formulations. The intake of phentermine in a capsule generally resulted in an excretion peak 4 h after the administration followed by a second peak 12 or 24 h post dosing. The total amount excreted during 72 h varied from 62.7 to 84.8%. Concerning the administration of Ionamine 15, a sustained release formulation, the maximal excretion rate was spread over 3-9 h, while more than 85% of phentermine were excreted after 72 h. The excretion was affected by urinary pH. The intake of acetazolamide shortly after phentermine resulted in a decrease of the phentermine excretion during one day and in one subject in a suppression below the detection limit 4 h post dosing. The administration of furosemide or bumetanide produced only a diluting effect during 2 h.
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology; D002034:Bumetanide / Q000494:pharmacology; D002214:Capsules; D003692:Delayed-Action Preparations; D004232:Diuretics / Q000494:pharmacology*; D004300:Doping in Sports; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D010645:Phentermine / Q000032:analysis / Q000652:urine*; D013997:Time Factors
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004232:Diuretics; D002034:Bumetanide; D005665:Furosemide; D010645:Phentermine; D000086:Acetazolamide