Influence of dietary protein on the pathophysiology of ovine haemonchosis in Finn Dorset and Scottish Blackface lambs given a single moderate infection.
Two experiments were conducted to examine the influence of dietary protein on the pathophysiology of Haemonchus contortus in lambs of two breeds, namely Finn Dorset and Scottish Blackface. Erythrokinetic and metabolic studies using 51Cr-red cells, 59Fe-transferrin and 125I-albumin, and digestive efficiency and nitrogen balance measurements were conducted between four and six weeks after infection. Identical radioisotopic and nutritional studies were also conducted on pair-fed control lambs of both breeds. The results demonstrated that in normal control animals, there were no significant effects of diet or breed on any of the erythrokinetic, metabolic or nutritional parameters, with the possible exception of red cell survival which was considerably longer in the Finn Dorset lambs. However, in the infected animals diet and breed did influence those parameters. The severest effects were seen in the infected Finn Dorset lambs given the low protein diet. These animals had the highest level of abomasal blood loss and this was associated with low red cell volumes and high levels of both albumin catabolism and plasma iron turnover. These animals were also in negative nitrogen balance which was partly accounted for by a significantly greater urinary nitrogen loss compared with their pair-fed controls and partly due to the poorer digestibility of the crude protein fraction of the diet. In contrast, although the infected Scottish Blackface lambs had high levels of blood loss and associated pathophysiological changes, these did not differ between dietary treatments and were similar to the changes in the infected Finn Dorset lambs given the high protein diet.
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism; D004063:Digestion; D004905:Erythrocyte Aging; D004911:Erythrocyte Volume; D005260:Female; D006188:Haemonchiasis / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary*; D007501:Iron / Q000097:blood; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D012756:Sheep / Q000235:genetics; D012757:Sheep Diseases / Q000378:metabolism / Q000503:physiopathology*; D014168:Transferrin / Q000378:metabolism; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D004044:Dietary Proteins; D012709:Serum Albumin; D014168:Transferrin; D007501:Iron; D009584:Nitrogen