Radioiodinated peanut lectin: clinical use as a tumour-imaging agent and potential use in assessing renal-tubular function.
Peanut lectin (PNA) has been shown to have a high affinity for Thomsen-Friedenreich (T) antigen, which is associated with the membrane of many solid tumour cells. PNA labelled with 131I was used as a tumour-imaging substance in patients with known metastatic cancer. Serial gamma scintiscans were obtained in 17 patients following a single injection of 131I-labelled PNA. Only in 1 patient was this technique able to reveal a known metastasis at analogue imaging. In the remaining patients, no visible uptake of 131I-PNA could be demonstrated at sites of known metastases. PNA is rapidly excreted through the kidneys and localizes in the renal tubules. As a tumour-imaging agent, 131I-PNA appears to be without value, but its renal-excretory characteristics make it a potentially useful agent for the in vivo assessment of renal-tubular disorders.
D006801:Humans; D007457:Iodine Radioisotopes; D007668:Kidney / Q000000981:diagnostic imaging; D007677:Kidney Function Tests; D037102:Lectins; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging*; D019887:Peanut Agglutinin; D011877:Radionuclide Imaging
D007457:Iodine Radioisotopes; D037102:Lectins; D019887:Peanut Agglutinin