A ninth complementation group in xeroderma pigmentosum, XP I.
A new complementation group of excision-deficient xeroderma pigmentosum (XP) is described in 2 patients living in the F.R.G. Dermatological, ophthalmological and neurological symptoms of XP are presented together with DNA repair characteristics such as unscheduled DNA synthesis, colony-forming ability and alkaline elution studied in cultured fibroblasts. The results are compared to normal controls.
D000293:Adolescent; D000328:Adult; D002273:Carcinogens / Q000494:pharmacology; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005816:Genetic Complementation Test; D006801:Humans; D008297:Male; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics*
D002273:Carcinogens; D004247:DNA