title: Psychophysiological reactivity in high-risk children.
abstract: This study was designed to test and extend previous reports of differences in autonomic responsivity between offspring of schizophrenic patients and control subjects. In specific, greater galvanic skin response (GSR) to stimuli and quicker GSR recovery have been reported in high-risk children. In the present study we found no evidence of autonomic hyperactivity, as evidenced by GSR to tones, in high-risk as compared to control subjects. There was some trend for index subjects to show slower GSR recoveries than control subjects, which is opposite to findings from earlier studies. Subjects were also presented with the Information Detection Test, in which GSR responses to emotionally meaningful vs. neutral stimuli were compared. Index children were less reactive than control subjects to the meaningful stimuli, and they discriminated between meaningful and neutral stimuli more poorly. Our findings do not confirm the learning theory of schizophrenia suggested by Mednick, but do suggest that developmental lags in high-risk as compared to control children may contribute to the psychophysiological differences that we found.
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D002648:Child; D005260:Female; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D008297:Male; D011930:Reaction Time; D012306:Risk; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology