title: Construction of human linkage maps: likelihood calculations for multilocus linkage analysis.
abstract: Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.
mesh_terms: D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D003433:Crosses, Genetic; D005163:Factor Analysis, Statistical; D005260:Female; D008040:Genetic Linkage; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D008297:Male; D008433:Mathematics; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D011995:Recombination, Genetic