Differentiation and the cell membrane excitability of teratocarcinoma OTT6050 in culture.
The electrophysiological properties of differentiated cells which were derived from teratocarcinoma OTT6050 in culture showed two different types of spike generation: (1) In the differentiated cells treated by retinoic acid, the action potential of cells involved Ca2+; (2) in the differentiated cells treated by both retinoic acid and nerve growth factor (NGF), the action potential of cells involved Na+ and CA2+. The results indicate that the effects of drugs appear to be important factors in the induction as well as in the regulation of cellular functions in the differentiated cells.
D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology; D009414:Nerve Growth Factors / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013724:Teratoma / Q000648:ultrastructure*; D014212:Tretinoin / Q000494:pharmacology
D009414:Nerve Growth Factors; D014212:Tretinoin; D012964:Sodium; D002118:Calcium