Biochemical RBC abnormalities in drug-free and lithium-treated manic patients.
RBCs from two lithium-free manic patients displayed lower choline transport and higher choline concentrations and methionine S-adenosyltransferase activity than those of controls. Lithium therapy decreased RBC methionine S-adenosyltransferase activity to normal, decreased choline transport further, and increased choline concentrations further.
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D002794:Choline / Q000032:analysis*; D004912:Erythrocytes / Q000032:analysis* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008716:Methionine Adenosyltransferase / Q000032:analysis* / Q000378:metabolism; D008875:Middle Aged; D010865:Pilot Projects; D014166:Transferases / Q000032:analysis*
D008094:Lithium; D014166:Transferases; D008716:Methionine Adenosyltransferase; D002794:Choline