title: Impairment of citrulline synthesis during late pregnancy and lactation in rats.
abstract: Synthesis of citrulline by rat liver mitochondria was investigated during late pregnancy and early lactation. It was strongly decreased over all the period studied except during delivery, where a sudden rise was observed. The mitochondrial enzymes carbamoylphosphate synthetase I (ammonia) (EC 6.3.4.16) and ornithine carbamoyltransferase (EC 2.1.3.3) did not fall significantly during this period, although carbamoylphosphate synthetase I (ammonia) was slightly decreased antepartum. Citrulline synthesis was found significantly correlated to N-acetylglutamate concentration in mitochondria throughout the period considered. On the other hand, low levels of N-acetylglutamate could be explained by low activity of N-acetylglutamate synthase (EC 2.3.1.1).
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism; D051046:Amino-Acid N-Acetyltransferase; D000818:Animals; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000378:metabolism; D002956:Citrulline / Q000096:biosynthesis*; D005260:Female; D005971:Glutamates / Q000096:biosynthesis; D007743:Labor, Obstetric; D007774:Lactation; D008930:Mitochondria, Liver / Q000378:metabolism*; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005971:Glutamates; D002956:Citrulline; D009954:Ornithine Carbamoyltransferase; D000123:Acetyltransferases; D051046:Amino-Acid N-Acetyltransferase; D002222:Carbamoyl-Phosphate Synthase (Ammonia); C016195:N-acetylglutamic acid