Effects of phenobarbital and p,p'-DDT on carboxylesterase activity and hydrolysis of propanidid in rat liver.
Time-dependent responses of microsomal and cytosolic carboxylesterases (EC 3.1.1.1) to administration of phenobarbital or p,p'-DDT were studied in rat liver using p-nitrophenylacetate and propanidid as substrates. In vitro and in vivo studies indicate that the hepatic carboxylesterases are induced by phenobarbital and p,p'-DDT. The induced metabolism of propanidid does not appear to be due to the microsomal polysubstrate monooxygenase system of the liver.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003600:Cytosol / Q000201:enzymology; D003634:DDT / Q000494:pharmacology*; D006207:Half-Life; D006868:Hydrolysis; D007700:Kinetics; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology*; D011410:Propanidid / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D011410:Propanidid; D003634:DDT; D002265:Carboxylic Ester Hydrolases; D010634:Phenobarbital