The effect of dietary or intraperitoneally injected seaweed preparations on the growth of sarcoma-180 cells subcutaneously implanted into mice.
Sixteen preparations from 9 edible seaweeds including powdered weed (P), hot-water extract (E), the non-dialyzable fraction (I) of E and the residue (R) of hot-water extraction were incorporated into a basic diet, and they were given to mice implanted with Sarcoma-180 cells s.c., for 5 weeks. Consequently, diets with 6 preparations, E of Laminaria angustata, P and E of Laminaria angustata var. longissima, and P, E and R of Laminaria japonica var. ochotensis, were found to be effective, with inhibition ratios ranging from 70.3% to 83.6%. Intraperitoneal injection of 10 preparations from 6 edible seaweeds, including the above 3 weeds, were also noted to be effective in the same test system, with inhibition ratios ranging from 61.9% to 95.2%.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004035:Diet Therapy / Q000379:methods; D004353:Drug Evaluation, Preclinical; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000628:therapy*; D012624:Seaweed; D012878:Skin Neoplasms / Q000628:therapy*; D013997:Time Factors
D010936:Plant Extracts