Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle.
Oxygen consumption and the activities of the selenoenzyme glutathione peroxidase, and of the hexose monophosphate shunt were lower than normal in neutrophils from Se deficient cattle. However, these activities and the activity of Cu/zinc superoxide dismutase were unaffected in neutrophils from Cu deficient cattle. These results are discussed with reference to impaired neutrophil microbicidal activity previously demonstrated to result from Se or Cu deficiency in cattle.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle; D003300:Copper / Q000172:deficiency*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood*; D008954:Models, Biological; D009504:Neutrophils / Q000201:enzymology*; D010101:Oxygen Consumption; D010427:Pentose Phosphate Pathway; D010587:Phagocytosis; D012643:Selenium / Q000172:deficiency*; D013482:Superoxide Dismutase / Q000097:blood*
D001786:Blood Glucose; D003300:Copper; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium