[Anticoagulant and nonenzymatic fibrinolytic activity of plasma in animals after intravenous injection of a heparin-antithrombin III complex].
The heparin-antithrombin III complex with a weight ratio 1:3 had a powerful anticoagulant and non-enzymatic fibrinolytic activity in vitro. Seven and 30 min after intravenous injection of the complex the animal blood plasma showed a considerable prolongation of the thrombin time and an increase in non-enzymatic fibrinolytic activity. The effect of heparin injected in a dose equivalent to its content in the complex on the parameters under study was appreciably less and disappeared by the 30th minute of the observation period.
D000818:Animals; D000990:Antithrombin III / Q000494:pharmacology*; D004338:Drug Combinations; D005342:Fibrinolysis; D006493:Heparin / Q000494:pharmacology*; D007275:Injections, Intravenous; D010949:Plasma / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013918:Thrombin Time; D013997:Time Factors
D004338:Drug Combinations; D000990:Antithrombin III; D006493:Heparin
Antikoaguliantnaia i nefermentativnaia fibrinoliticheskaia aktivnost' plazmy zhivotnykh posle vnutrivennoĭ in"ektsii kompleksa geparin-antitrombin III.