An attempt to differentiate female relatives of Duchenne type dystrophy from healthy subjects using an automatic EMG analysis.
A new automatic EMG analysis and on-line assignment of MUAP into 8 dynamic cluster algorithm classes (P1......P8) were applied to female relatives of patients with Duchenne type dystrophy. Promising results are given. MUAP amplitude and duration differed significantly in the female relatives compared to the control subjects. MUAP distribution patterns found in the carrier population were significantly different from those found in controls; the carrier population exhibited higher percentages of MUAP (than healthy subjects) in the classes where were assigned the great majority of the potentials obtained from patients with Duchenne type dystrophy. All the known carriers and 55.5% of the possible carriers were detected using these methods. Nevertheless, the absolute accuracy of the results cannot yet be considered achieved because no recognizable distribution pattern was observed in carrier's daughters. No correlation was found between CK levels and EMG distribution.
D000328:Adult; D000367:Age Factors; D003402:Creatine Kinase / Q000097:blood; D004576:Electromyography / Q000379:methods*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods; D006801:Humans; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000175:diagnosis*
D003402:Creatine Kinase