Water and electrolyte absorption from a human Thiry-Vella ileal loop. Responses to systemic administration of gastrin, glucagon, secretin, and cholecystokinin.
Water and electrolyte flux in response to systemic administration of four different gastrointestinal hormones were studied in a human with a chronic Thiry-Vella ileal loop. Gastrin infusion with a pharmacological dose of 4 micrograms/kg-hr has no effect. Responses to glucagon were proportional to infused doses with directly increased absorption of water and electrolytes (except bicarbonate). However, when gastrin was infused simultaneously with glucagon, the enhanced absorption was inhibited. Secretin only transiently increased absorption of fluid and electrolytes. In contrast to its effects on jejunum, CCK increased both water and electrolyte absorption from the ileum.
D002766:Cholecystokinin / Q000008:administration & dosage / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D005755:Gastrins / Q000008:administration & dosage / Q000494:pharmacology*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D014867:Water / Q000378:metabolism*
D004573:Electrolytes; D005755:Gastrins; D014867:Water; D012633:Secretin; D005934:Glucagon; D002766:Cholecystokinin