Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by tricyclic antidepressants and mazindol: case report.
A 43-year-old man who experienced profound dose-related erectile and ejaculatory dysfunction without loss of libido on three separate antidepressants and on the anorectic agent mazindol is described. Bethanechol chloride 20 mg p.o., taken 1 to 2 hours prior to sexual activity, permitted satisfactory erection and ejaculation during sexual intercourse, while the patient continued to take protriptyline or mazindol. Bethanechol chloride may prove to be of use in treating sexual dysfunction associated with drugs or conditions which increase sympathetic tone.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D001626:Bethanechol Compounds / Q000627:therapeutic use*; D004542:Ejaculation / Q000187:drug effects; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000188:drug therapy / Q000523:psychology; D006801:Humans; D006963:Hyperphagia / Q000188:drug therapy; D007211:Indoles / Q000009:adverse effects*; D007989:Libido; D008297:Male; D008454:Mazindol / Q000009:adverse effects*; D010410:Penile Erection / Q000187:drug effects; D011530:Protriptyline / Q000009:adverse effects
D000929:Antidepressive Agents, Tricyclic; D001626:Bethanechol Compounds; D007211:Indoles; D011530:Protriptyline; D008454:Mazindol