Chronic portal hypertension: effects on gastrointestinal blood flow distribution.
The intramural distribution of blood flow in the gastrointestinal tract was measured in shamoperated control and portal vein-stenosed rats. Total organ blood flow, measured via the radioactive microsphere technique, was elevated in the esophagus (66%), stomach (102%), duodenum (42%), jejunum (52%), ileum (54%), and colon (79%) of portal-hypertensive rats. Histological evaluation of carbonized nonradioactive 15-microns microspheres allowed for fractionation of blood flow within the wall (mucosa, submucosa, and muscularis externa) of each organ. The microsphere distribution pattern indicates that intramural blood flow distribution in all organs was not dramatically affected by chronic portal hypertension. These findings further define the characteristics of the factors responsible for the gastrointestinal hyperemia produced by chronic portal hypertension.
D000818:Animals; D004064:Digestive System / Q000098:blood supply*; D006975:Hypertension, Portal / Q000503:physiopathology*; D008433:Mathematics; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow