Comparative function of centrifugal apheresis devices.
The function of four apheresis devices has been evaluated to obtain comparative data on performance and safety. Granulocyte yields were highest with the CS-3000 with 1.7 X 10(10) cells, but this preparation also contained 4.5 X 10(11) platelets; plateletpheresis gave ranges of 3.4 X 10(11) to 4.5 X 10(11) cells. The amount of blood processed to obtain these yields varied greatly, ranging from 2.4 to 7 liters. Studies done on the donor return line showed no significant effects of the process. Comparative results on the efficacy of plasma exchange showed relatively little red cell contamination with any of these devices, but significant (6.9 X 10(10) platelet removal in the Fenwal bag.
D002469:Cell Separation / Q000295:instrumentation*; D002498:Centrifugation / Q000295:instrumentation; D005069:Evaluation Studies as Topic; D006098:Granulocytes; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation*; D010983:Plateletpheresis / Q000295:instrumentation*