Immune complexes and autoantibodies in patients with giant cell arteritis and their relationship with autologous rosette-forming cells.
Serologic studies and lymphocyte analysis were carried out in 29 patients with giant cell arteritis (GCA). IgA-containing circulating immune complexes (CIC) were detected in 16 GCA patients with or without polymyalgia rheumatica (55%). A significant difference was demonstrated in autologous rosette-forming cells between the patients as a whole, and matched controls (8.6 +/- 2.0 vs 11.6 +/- 2.4, p less than 0.001), and also between patients with and patients without CIC (7.9 +/- 1.6 vs 9.4 +/- 2.0, p less than 0.001).
D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000150:complications; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007136:Immunoglobulins; D003165:Complement System Proteins