The effect of prednisolone on the foetotoxicity of cadmium in pregnant mice.
The effects of prednisolone was investigated on the foetotoxicity of cadmium. CFLP female mice were given a single i.p. dose of 2.5 mg cadmium (Cd) per kg body weight on day 5 or 9 of gestation. This treatment significantly decreased both the number of live foetuses and foetal weights on day 18 of gestation. Prednisolone (0.1 mg kg-1) given daily from the day of cadmium treatment death, prevented the effects of cadmium on foetal weights in both groups, and on the number of live foetuses when cadmium was given on day 9 of gestation. When Cd was given on day 13 of gestation similar treatment with prednisolone did not influence either litter size or the weights of 1-day-old pups.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005333:Fetus / Q000187:drug effects*; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D011239:Prednisolone / Q000494:pharmacology*; D011247:Pregnancy
D002104:Cadmium; D011239:Prednisolone