title: Effects of dehydration on the vasopressin response to immersion.
abstract: Nine healthy volunteers underwent three experimental procedures in random order. The protocols were 4 h of thermal dehydration followed by 2 h of head-out water immersion, 4 h of thermal dehydration followed by 2 h of chair rest, and 6 h of rest in the supine position. Four hours of heat exposure (50 degrees C) resulted in a body weight loss of approximately 3.5%. Plasma osmolality rose by approximately 5 mosmol/kg, mean arterial pressure (MAP) decreased from 85 to 78 mmHg, and body temperature increased from 36.8 to 38.6 degrees C. As a consequence of the combined action of hypertonicity, hypovolemia, hypotension, and hyperthermia, plasma arginine vasopressin (AVP) increased from 2.1 to 8.1 pg/ml after 4 h thermal dehydration. Changes in body weight, plasma osmolality, body temperature, and MAP were similar after either a subsequent 2 h of water immersion or 2 h of chair rest. However, during chair rest plasma AVP remained elevated (8.4 pg/ml), whereas during immersion plasma AVP decreased from 8.1 to 4.7 pg/ml. This was probably due to the central hypervolemia induced by immersion. Our results support the hypothesis that central hypervolemia rather than hypotonicity is the primary stimulus for AVP suppression during water immersion in dehydrated subjects. During the early immersion period hypoosmolality might contribute to the AVP suppression.
mesh_terms: D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood / Q000502:physiology*; D001794:Blood Pressure; D001798:Blood Proteins / Q000378:metabolism; D001810:Blood Volume; D001831:Body Temperature; D001835:Body Weight; D003681:Dehydration / Q000503:physiopathology* / Q000652:urine; D006339:Heart Rate; D006801:Humans; D007101:Immersion / Q000503:physiopathology*; D009994:Osmolar Concentration
chemical_list: D001798:Blood Proteins; D001127:Arginine Vasopressin