Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children.
In the present study, plasma DBH activity and urinary HVA levels were measured in 19 autistic and 15 normal children. DBH activity was significantly elevated in the 8 less retarded autistic patients. In this subgroup, a negative correlation was found between plasma DBH and urinary HVA levels. These results support the hypothesis of a possible involvement of brain catecholamine dysfunction in the production of autistic symptoms.
D000367:Age Factors; D001321:Autistic Disorder / Q000097:blood* / Q000652:urine; D001923:Brain Chemistry; D002395:Catecholamines / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D005260:Female; D006719:Homovanillic Acid / Q000652:urine*; D006801:Humans; D008297:Male
D002395:Catecholamines; D004299:Dopamine beta-Hydroxylase; D006719:Homovanillic Acid