Inhibitors for distinction of three types of human glutathione transferase.
A set of inhibitors that are useful for distinction of three types of human cytosolic glutathione transferase is presented. The near-neutral transferase is inhibited most effectively by Cibacron blue (I50 = 0.05 microM), the acidic transferase by Cibacron blue (I50 = 0.5 microM), and the basic transferase by tributyltin acetate (I50 = 0.1 microM). The use of any of these two compounds makes possible differentiation between all three types of human transferase.
D003600:Cytosol / Q000201:enzymology; D005260:Female; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D014220:Trialkyltin Compounds / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology
D007527:Isoenzymes; D014220:Trialkyltin Compounds; D014227:Triazines; C011559:tributyltin; C012842:Cibacron Blue F 3GA; D005982:Glutathione Transferase