A substrate analog inhibitor for arylsulfatase reduces NK cell cytotoxicity.
A synthetic aromatic sulfonate (I), which has been found to be an effective inhibitor of arylsulfatase, reduces NK-cell mediated cytotoxicity by ca. 60% at 10 microM concentration. At lower concentrations the effect is concentration dependent, but no further reduction of cytotoxicity is observed at concentrations above 10 microM.
D000818:Animals; D001192:Arylsulfatases / Q000037:antagonists & inhibitors*; D001557:Benzenesulfonates / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007700:Kinetics; D008698:Mesylates; D013429:Sulfatases / Q000037:antagonists & inhibitors*
D001557:Benzenesulfonates; D008698:Mesylates; C044452:2-hydroxy-5-nitro-alpha-toluenesulfonic acid; D013429:Sulfatases; D001192:Arylsulfatases