Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs.
Dermatosis in magnesium-deficient hairless rats has been described as a reproducible model of skin inflammation. It was therefore felt of interest to search for the effects of various anti-inflammatory compounds on this model. Results showed that 1) Dexamethasone acetate completely abolished the rash, 2) Indomethacin, a Non-Steroidal Anti-Inflammatory Drug (NSAID), inhibitor of the cyclooxygenase pathway was quite inactive, 3) Benoxaprofen, a NSAID inhibitor of both cyclooxygenase and lipoxygenase pathways only slightly modified the development of the pathology. Activity of steroidal anti-inflammatory drugs on this model may be related to their immunosuppressive effects.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D003907:Dexamethasone / Q000627:therapeutic use; D004032:Diet; D007213:Indomethacin / Q000627:therapeutic use; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011422:Propionates / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011422:Propionates; D013256:Steroids; C011677:benoxaprofen; D003907:Dexamethasone; D008274:Magnesium; D007213:Indomethacin