Adenosine deaminase complexing protein (ADCP) immunoreactivity in colorectal adenocarcinoma.
Immunoreactive adenosine deaminase complexing protein (ADCP) was studied in 91 human colorectal adenocarcinomas. The expression of ADCP was correlated with that of secretory component (SC) and carcinoembryonic antigen (CEA), with the histological grade and the Dukes' stage of the carcinomas. The histological grade was scored semi-quantitatively according to 5 structural and 4 cytological variables. ADCP expression was observed in 3 different staining patterns, namely: (1) diffuse cytoplasmic (77% of the carcinomas); (2) granular cytoplasmic (13%); and (3) membrane-associated (66%). These patterns were observed alone or in combination. Eleven percent of the carcinomas exhibited no ADCP immunoreactivity. Linear regression analysis showed that the expression of ADCP correlates with that of SC and CEA. However, no significant correlation emerged between the histological parameters or the Dukes' stage and any of the immunohistological parameters. Comparison of the histological characteristics of carcinomas exhibiting little or no ADCP immunoreactivity with those showing extensive immunoreactivity, showed that membranous ADCP immunoreactivity occurs more frequently in well-differentiated carcinomas. Structural parameters showed a better correlation with membranous ADCP expression than the cytological variables. It is concluded that membranous expression of ADCP and CEA are indicators of a high level of differentiation as reflected primarily in the structural characteristics of the tumor.
D000230:Adenocarcinoma / Q000032:analysis* / Q000473:pathology; D000243:Adenosine Deaminase / Q000032:analysis* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003110:Colonic Neoplasms / Q000032:analysis* / Q000473:pathology; D018819:Dipeptidyl Peptidase 4; D006023:Glycoproteins / Q000032:analysis* / Q000276:immunology; D006801:Humans; D009700:Nucleoside Deaminases / Q000032:analysis*; D012004:Rectal Neoplasms / Q000032:analysis* / Q000473:pathology; D012635:Secretory Component / Q000032:analysis
D002272:Carcinoembryonic Antigen; D006023:Glycoproteins; D012635:Secretory Component; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase