[Food inhibitors of the formation of carcinogenic nitroso compounds].
A study was made of the effect of plant preparations, pectin, plantastin, tiliaflan, cholosas and carbonic acid phytoextract from the fruit of the Umbelliferae family (CO2-EP) on the synthesis of carcinogenous nitrosodimethylamine from amidopyrine and sodium nitrite. Gas chromatography made in vitro and in short-term experiments on animals demonstrated plantastin to display an inhibitory action, which was less marked for tiliaflan, CO2-EP and cholosas. The system of experiments in question may be recommended for preliminary screening of the inhibitors of nitrosation with a purpose of using them for the prophylaxis of carcinogenesis induced by nitroso compounds.
D000818:Animals; D005260:Female; D005506:Food Contamination; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects; D008297:Male; D009603:Nitroso Compounds / Q000037:antagonists & inhibitors*; D010368:Pectins / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010943:Plantago; D010945:Plants, Edible; D010946:Plants, Medicinal; D051381:Rats
D009603:Nitroso Compounds; D010936:Plant Extracts; C045028:plantastin; C045029:tiliaflan; D010368:Pectins
Pishchevye ingibitory obrazovaniia kantserogennykh nitrozosoedineniĭ.