JTC-11 cells derived from Ehrlich ascites tumor deficient in a growing medium containing citrulline.
JTC-11 cells derived from an Ehrlich ascites tumor do not proliferate and do not synthesize DNA in a medium which contains citrulline but not arginine. Mouse L and HeLa cells grew well in citrulline medium. Since JTC-11 cells have been transplanted intraperitoneally in vivo and cultured in vitro for a long period, these cells may spontaneously lose the ability to synthesize arginine from citrulline.
D000818:Animals; D001120:Arginine / Q000172:deficiency*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002455:Cell Division; D002460:Cell Line; D002956:Citrulline / Q000378:metabolism*; D003470:Culture Media; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007739:L Cells / Q000378:metabolism; D051379:Mice
D003470:Culture Media; D004273:DNA, Neoplasm; D002956:Citrulline; D001120:Arginine