Neuropsychologic detection of abnormal mental decline in older persons.
We conducted comprehensive neuropsychologic assessment in normal 60- to 88-year-old persons and in patients with dementia of various causes, matched for age and sex. Patients with dementia performed significantly poorer on tests of short-term memory, temporal orientation, visual perception, and language. Further data analysis, including multivariate classification procedures, identified a combination of three tests (Visual Retention, Controlled Oral Word Association, and Temporal Orientation) that in a cross-validation study correctly classified 89% of cases with a high degree of probability. Only 6.5% of cases were misclassified, while 4.5% were in a questionable, borderline category. The battery constituted by these three discriminating tests provides a brief, easily administered neuropsychologic screening instrument that may be used by a variety of health professionals for the detection of abnormal mental decline in older persons.
D000368:Aged; D001499:Bayes Theorem; D003704:Dementia / Q000175:diagnosis*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007807:Language Tests; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000379:methods*; D013223:Statistics as Topic; D013998:Time Perception; D014796:Visual Perception