[Carcinogenic activity of dioxidine].
A study was made of the blastomogenic activity of dioxydin, a new antibacterial broad-action drug. Administration of dioxydin in doses of 20-100 mg/kg (exceeding 2-10-fold the therapeutic dose for humans) to mice and rats intragastrically for 18 months and intraperitoneally (2 years of observation) as well as combined administration of the drug to rats transplacentally and postnatally (1.5 years of observation) did not induce any neoplasms.
D000818:Animals; D000831:Animals, Newborn; D000890:Anti-Infective Agents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D010920:Placenta; D011247:Pregnancy; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats; D012996:Solutions; D013997:Time Factors
D000890:Anti-Infective Agents; D011810:Quinoxalines; D012996:Solutions; C001077:dioxidine
Izuchenie kantserogennoĭ aktivnosti dioksidina.