title: Endothelial mitochondrial content of cerebral cortical capillaries in Alzheimer's disease. An ultrastructural quantitative study.
abstract: The mitochondrial content of endothelial cells of cerebral cortical capillaries in patients with Alzheimer's disease and age-matched controls was calculated using stereologic methods. No morphologic abnormalities or quantitative changes in endothelial mitochondria are reported. Our findings do not support the hypothesis of a blood-brain barrier defect in Alzheimer's disease.
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D002196:Capillaries / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000098:blood supply*; D004727:Endothelium / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure*