title: The effect of chamber restraint (with or without lower body positive pressure) on hematopoiesis (particularly erythropoiesis) in squirrel monkeys (Saimiri sciureus)
abstract: Squirrel monkeys, restrained in lower body positive pressure (LBPP) chambers in attempts to model the space flight-induced hematological consequences of a cephalad fluid shift, showed a decrease in red blood cell mass which was largely independent of actual LBPP. The only LBPP-specific hematological effect was an alteration in red blood cell (RBC) survival. This monkey model represents the second, ground-based animal system in which this phenomenon has been recorded and shown to be unique to a cephalad fluid shift. These data suggest a re-evaluation is necessary of the role of altered RBC clearance as a contributing factor to the anemia of space flight in humans.
mesh_terms: D000337:Aerospace Medicine; D000818:Animals; D002427:Cebidae / Q000502:physiology*; D004780:Environment, Controlled / Q000009:adverse effects*; D004905:Erythrocyte Aging; D004920:Erythropoiesis; D006410:Hematopoiesis; D007958:Leukocyte Count; D008297:Male; D008954:Models, Biological; D011312:Pressure; D012149:Restraint, Physical; D012453:Saimiri / Q000502:physiology*; D013997:Time Factors