A new model of arterial thrombosis.
A new model of arterial thrombosis in rats was based on a combination of a localizing hemodynamic factor /partial mechanical constriction of aorta/, generalized mild endothelial lesion /i.v.hypotonic saline/ and a humoral factor/i.v. serotonin/. The resulting aortic occlusion was indicated by measuring rectal temperature. Nicotine and oral methionine were similarly active as hypotonic saline. Histamine had to some extent similar activity as serotonin. The possible contribution of serotonin vasoactivity to the vascular obstruction was contradicted.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004727:Endothelium / Q000502:physiology; D005260:Female; D006461:Hemolysis; D007038:Hypotonic Solutions; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012965:Sodium Chloride; D013927:Thrombosis / Q000209:etiology*
D007038:Hypotonic Solutions; D012701:Serotonin; D012965:Sodium Chloride