title: Properties of macrophages from low- and high-responder strains of mice. I. Effect of antigenic stimulation.
abstract: In the high-responder A/J mice a lower percentage of peritoneal macrophages express Fc receptors and accordingly phagocytize less intensely via these receptors than the macrophages of the low-IgG-responder C57BL/10ScSn strain. Similarly, the phagocytosis mediated by the receptors for foreign substances tested by CdCO3 microcrystals is lower in the A/J strain. Pinocytic activity was the same in both mouse strains. Intraperitoneal immunization with sheep red blood cells led to a prompt increase in Fc receptor expression and in both phagocytic and pinocytic activities in A/J mice, while in C57BL/10ScSn mice these activities remained unchanged. A similar effect was found when spontaneous and induced rosette formation with sheep red blood cells was studied. The opposite was true when the phagocytic activity of peripheral leucocytes to non-antigenic synthetic microspheres was studied; after immunization with sheep red blood cells a strong increase was observed not in the A/J but C57BL/10ScSn strain. The importance of these results for the regulatory role of macrophages in immune responses in the low- and high-IgG-responder strains of mice is discussed.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D001202:Ascitic Fluid; D002104:Cadmium; D002254:Carbonates; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D008264:Macrophages / Q000276:immunology*; D008689:Methacrylates; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D010873:Pinocytosis; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation; D012756:Sheep
chemical_list: D000941:Antigens; D002254:Carbonates; D008689:Methacrylates; D011961:Receptors, Fc; D002104:Cadmium; C038075:cadmium carbonate; C005044:hydroxyethyl methacrylate