A new erythrocytic antigen of C57BL/10 (B10) mice.
A new antigen, detectable on murine erythrocytes by hemagglutination assay with a (BALB/cCrl X SWR/J)F1 anti-B10.D2n/Sn alloantiserum, is described. Among the inbred and congenic mouse strains tested for reactivity with the antiserum, only the immunizing strain, B10.D2, and its congenic resistant partner, C57BL/10 (B10), reacted. Three other C57 strains, C57BL/6J, C57BL/6By, and C57L, were negative for the antigen. F1 hybrids between B10 and BALB/c, an antigen-negative strain, were positive for the antigen indicating that its expression is dominant. Typing of 39 (BALB/c X (BALB/c X B10)F1) and 62 [BALB/c X B10)F1 X BALB/c) backcross mice revealed that a single gene controls expression of the antigen. The gene is autosomal and not linked to H-2, Ly-4, or the c (albino) or b coat color genes.
D000818:Animals; D001789:Blood Group Antigens; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D007518:Isoantibodies / Q000276:immunology; D007519:Isoantigens / Q000032:analysis*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood*
D001789:Blood Group Antigens; D007518:Isoantibodies; D007519:Isoantigens