Regulation of gastric acid secretion by secretin and serotonin.
We have tested the interaction between serotonin and secretin in pentagastrin-induced gastric acid secretion in six dogs prepared with Thomas gastric and duodenal cannulas. We further examined the effect of methysergide, a serotonin antagonist, on gastric acid secretion. The intravenous administration of serotonin or secretin alone significantly inhibited pentagastrin-induced gastric acid secretion. The combined administration of serotonin and secretin inhibited gastric acid secretion to a greater magnitude than either secretagogue alone. The administration of methysergide diminished basal concentrations of secretin on gastric acid secretion. Methysergide also enhanced the stimulatory activity of pentagastrin-induced gastric acid secretion. The inhibitory action of intraduodenal acidification of pentagastrin-induced gastric acid secretion was reversed by methysergide.
D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D004386:Duodenum / Q000187:drug effects; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology; D007263:Infusions, Parenteral; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D012633:Secretin / Q000097:blood / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013997:Time Factors
D005755:Gastrins; D012633:Secretin; D012701:Serotonin; D010418:Pentagastrin; D006851:Hydrochloric Acid; D008784:Methysergide