title: Hormonal influence on experimental infections by a toxic shock strain of Staphylococcus aureus.
abstract: Subcutaneous infection chambers in rabbits were infected with a strain of Staphylococcus aureus isolated from a patient with toxic shock syndrome. Estrogens (mestranol and 17-beta-estradiol) protected male rabbits and prolonged survival. Neither androgens (testosterone and dihydrotestosterone) nor progesterone affected the susceptibility of intact or ovarihysterectomized female rabbits.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins; D004768:Enterotoxins / Q000633:toxicity*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D008656:Mestranol / Q000494:pharmacology; D009919:Orchiectomy; D010052:Ovariectomy; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D018089:Superantigens; D013739:Testosterone / Q000097:blood
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D012739:Gonadal Steroid Hormones; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D008656:Mestranol