Effects of plasma treatment with purified protein A and Staphylococcus aureus Cowan I on spontaneous animal neoplasms.
Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semi-automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral "blocking" factors.
D000818:Animals; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009369:Neoplasms / Q000628:therapy / Q000662:veterinary*; D010477:Perfusion / Q000379:methods*; D010949:Plasma; D012685:Sepharose / Q000008:administration & dosage; D013205:Staphylococcal Protein A / Q000008:administration & dosage*; D013211:Staphylococcus aureus
D007074:Immunoglobulin G; D013205:Staphylococcal Protein A; D012685:Sepharose