The pharmacokinetics of oral and intravenous prenalterol in young, healthy volunteers.
The pharmacokinetics of prenalterol in healthy young volunteers after i.v. and oral dosing has been studied. There is evidence of non-linearity following the i.v. dosing. Evidence of dose-dependent pharmacokinetics following i.v. dosing has been obtained. The sustained-release formulation is very effective: almost 12 h were needed to achieve 50 per cent of the total AUC.
D000284:Administration, Oral; D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011217:Practolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D011294:Prenalterol
D003692:Delayed-Action Preparations; D011294:Prenalterol; D011217:Practolol