title: Aspirin intolerance and asthmal induction of a tolerance and long-term monitoring.
abstract: Acetylsalicylic-acid (ASA) intolerance is well recognized as a possible cause for exacerbating asthma. It has been postulated that if this could be overcome, long-term aspirin administration could improve asthma symptoms and enable reduction of the use of other anti-asthmatic drugs. We succeeded in inducing an ASA tolerance in nine corticosteroid-dependent asthmatics, and this tolerance lasted at least 1 month and at most 1 year. Progressive deterioration in lung function was seen, however, in all patients taking ASA for more than 1 month, unless the corticosteroid intake was increased. These results suggest that ASA long-term treatment is of no help to severe corticosteroid-dependent, ASA-sensitive asthmatics. This conclusion differs from other reports on ASA intolerance in asthma.
mesh_terms: D000328:Adult; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000628:therapy; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D012137:Respiratory System / Q000503:physiopathology; D013997:Time Factors
chemical_list: D001241:Aspirin