title: Differentiation and the cell membrane excitability of teratocarcinoma OTT6050 in culture.
abstract: The electrophysiological properties of differentiated cells which were derived from teratocarcinoma OTT6050 in culture showed two different types of spike generation: (1) In the differentiated cells treated by retinoic acid, the action potential of cells involved Ca2+; (2) in the differentiated cells treated by both retinoic acid and nerve growth factor (NGF), the action potential of cells involved Na+ and CA2+. The results indicate that the effects of drugs appear to be important factors in the induction as well as in the regulation of cellular functions in the differentiated cells.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D004558:Electric Stimulation; D004594:Electrophysiology; D009414:Nerve Growth Factors / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D013724:Teratoma / Q000648:ultrastructure*; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D009414:Nerve Growth Factors; D014212:Tretinoin; D012964:Sodium; D002118:Calcium