Gamma-2MSH is natriuretic in the rat.
Previous reports suggest that peptides containing an amino acid sequence similar to that of ACTH-(4-10) increased Na excretion in the rat. gamma 2MSH contains such a sequence. An in vivo rat bioassay for natriuretic factors was employed to demonstrate the natriuretic action of gamma 2MSH. A significant natriuretic effect was observed, with a peak response 30-50 min following the bolus injections of 0.64, 6.4 or 64 pmol, but not with smaller or larger amounts of gamma 2MSH. A kaliuretic and diuretic action of gamma 2MSH was not consistently evident. gamma MSH may represent an endogenous compound involved in the physiological regulation of Na excretion.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000494:pharmacology*; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000652:urine; D051381:Rats / Q000652:urine*; D011919:Rats, Inbred Strains; D013997:Time Factors
D009074:Melanocyte-Stimulating Hormones; D011188:Potassium