Circling behavior induced by phencyclidine in mice and its inhibition by naloxone.
Phencyclidine (PCP), when given to mice, induces general hyperactivity and rapid circling, similar to that caused by morphine. These effects are partially antagonized by naloxone.
D000818:Animals; D007700:Kinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D010622:Phencyclidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012399:Rotation
D009270:Naloxone; D009020:Morphine; D010622:Phencyclidine