title: [Drug toxicity in piglets following long-term consumption of medicated feed].
abstract: The effect of the addition of various drugs to the feed on the performance of recent weaned piglets was studied. The following procedures were examined: no additive, 50 ppm of carbadox, 50 ppm of carbadox plus 400 ppm of furazolidone, 50 ppm of carbadox plus 22 ppm of lincomycin plus 22 ppm of spectinomycin, 400 ppm of furazolidone and 22 ppm of lincomycin plus 22 ppm of spectinomycin. Each treatment was carried out in ten groups of eight piglets. The trials were continued from the fifth to the eighth week of life. Addition of lincomycin and spectinomycin improved both growth and feed conversion. Combined administration of lincomycin and spectinomycin with carbadox resulted in the best performance. Supplementation of carbadox alone did not produce any beneficial effects. Addition of 400 ppm of furazolidone resulted in a significant depression of growth. Combined administration of 400 ppm furazolidone and 50 ppm of carbadox resulted in the poorest performance. The growth depressing effect of this combined treatment was observed as early as the first two weeks of the experiment. The animals undergoing this treatment showed a greyish-white colour of the skin and very hard stools.
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D004338:Drug Combinations; D005503:Food Additives / Q000633:toxicity*; D006128:Growth / Q000187:drug effects*; D008660:Metabolism / Q000187:drug effects; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D005503:Food Additives
vernacular_title: Geneesmiddel-intoxicaties bij biggen na langdurig gebruik van gemedicineerd voeder.