title: [Light optical and electron microscopic studies of the tumor cells in rats exposed to vinblastine against a background of increased activity of the anticoagulating system].
abstract: It is shown that the damage of sarcoma 45 cells at different stages of cell life cycle occurs under the effect of vinblastine treatment against a background of higher activity of the blood anticoagulating system. A decrease in the mitotic activity, mitosis accumulation in prophase and especially in the metaphase as well as essential changes in the interphase cell ultrastructure are detected.
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000627:therapeutic use; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000503:physiopathology / Q000648:ultrastructure*; D014508:Urea / Q000627:therapeutic use; D014747:Vinblastine / Q000627:therapeutic use*
chemical_list: D014747:Vinblastine; D014508:Urea; D006493:Heparin; D002746:Chlorpromazine
vernacular_title: Svetoopticheskoe i élektronno-mikroskopicheskoe issledovanie opukholevykh kletok krys pri deĭstvii vinblastina na fone povyshennoĭ aktivnosti protivosvertyvaiushcheĭ sistemy.