title: Interaction of 5-iminodaunorubicin with Fe(III) and with cardiolipin-containing vesicles.
abstract: 5-Iminodaunorubicin is an anthracycline derivative exhibiting promising antitumor activity. Using potentiometric and spectroscopic measurements we have shown that 5-iminodaunorubicin forms with Fe(III) a complex in which three molecules of drug are bound to one Fe(III) ion. Each molecule is chelated through the C-12-carbonyl and the C-11-phenolate oxygen atoms. The stability constant is 1.6 X 10(34). Using circular dichroism measurements we have studied the interactions of 5-iminodaunorubicin with cardiolipin-containing vesicles. We have shown that cardiolipin could bind one molecule of drug without penetration of the dihydroanthraquinone moiety into the bilayer.
mesh_terms: D002308:Cardiolipins; D002942:Circular Dichroism; D003630:Daunorubicin / Q000031:analogs & derivatives*; D005290:Ferric Compounds; D006863:Hydrogen-Ion Concentration; D007501:Iron; D008051:Lipid Bilayers; D011199:Potentiometry; D013057:Spectrum Analysis
chemical_list: D002308:Cardiolipins; D005290:Ferric Compounds; D008051:Lipid Bilayers; D007501:Iron; C018979:5-iminodaunorubicin; D003630:Daunorubicin