Solitary pelvic neural tumors with high steroid receptor content.
Two pelvic benign neural tumors, a neurofibroma and a neurilemmoma, were found to have high levels of cell nuclear estrogen receptors and both cytoplasmic and nuclear progestin receptors. A review of the literature reveals that neurogenic tumors occur predominantly in young women. This observation together with the recent findings of elevated sex steroid receptor proteins in meningiomas supports a hypothesis for the common hormonal dependence of neoplasms arising from the neural supporting tissues.
D000328:Adult; D001665:Binding Sites; D002467:Cell Nucleus / Q000032:analysis; D002850:Chromatography, Gel / Q000379:methods; D003593:Cytoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009442:Neurilemmoma / Q000032:analysis* / Q000473:pathology; D009455:Neurofibroma / Q000032:analysis* / Q000473:pathology; D010386:Pelvic Neoplasms / Q000032:analysis* / Q000473:pathology; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid