[Chromosome imbalance and cellular proliferation potential in vitro].
The effect of chromosome unbalance on the cell proliferative potential (cloning efficiency) was studied. The proliferative potential of the cells obtained from spontaneous abortions with chromosome unbalance appeared drastically reduced as compared with the proliferative potential of the cells from medical abortions. Chromosome unbalance in postnatal cells did not lead to diminution of the proliferative potential as compared with control.
D000022:Abortion, Spontaneous / Q000235:genetics / Q000473:pathology; D000328:Adult; D002455:Cell Division; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D009006:Monosomy; D011247:Pregnancy; D012867:Skin / Q000473:pathology; D014314:Trisomy
Khromosomnyĭ disbalans i proliferativnyĭ potentsial kletok in vitro.