Cyclosporin A enhances the survivability of mouse cerebral cortex grafted into the third ventricle of rat brain.
The effect of the immunosuppressant cyclosporin A on the survivability of newborn mouse cerebral cortex transplanted into the third ventricle of adult rats was investigated. Hematoxylin staining revealed that the transplanted mouse brain tissue was rejected by 4 weeks after the transplantation in the control group. In contrast, a large mass of grafted tissue was clearly detected in the third ventricle even 4 weeks after the transplantation in the cyclosporin A-treated group, and the grafted tissue was heavily stained with Thy-1.2 mouse monoclonal antibody. The results indicate that cyclosporin A is an effective immunosuppressant in neuronal transplantation as well as in transplantation of other organs.
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000637:transplantation*; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical
D003524:Cyclosporins