Anti-Dob implicated as the cause of a delayed hemolytic transfusion reaction.
A 27-year-old, gravida 3, para 2 woman experienced a delayed hemolytic transfusion reaction. She had anti-Dob in both serum and eluate 8 days after infusion of 6 units of Do(b+) red cells. No antibody had been detected prior to transfusion. By the 15th day after transfusion, there was no evidence of survival of red cells from any of the 6 units. Anti-C and anti-M were demonstrated later, but 29 months after transfusion, no atypical antibodies were detectable. The evidence suggests anti-Dob should be considered an antibody of potential clinical significance until contrary evidence becomes available.
D000328:Adult; D000937:Antigen-Antibody Reactions; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D003298:Coombs Test; D005260:Female; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000008:administration & dosage* / Q000032:analysis / Q000502:physiology; D013997:Time Factors; D065227:Transfusion Reaction
D001789:Blood Group Antigens; D007518:Isoantibodies