[Estrogen and progesterone receptors in malignant melanoma, benign pigmented nevi and basocellular epithelioma].
45 malignant melanomas, 10 benign nevi and 17 basal cell carcinomas were investigated for estradiol (ER) and progesterone (PR) receptor activity by a single saturating-dose method (5 nM for ER and 10 nM for PR) using DCC. ER were found respectively in 7%, 10% and 24% of the studied samples and PR in 18%, 40% and 29% of the same samples. The low rates of ER+ and PR+ samples were discussed according to the data of the literature, more specially to the weak results obtained with anti-estrogenic therapy and to the possibility of tyrosinase to mimic the estrogen binding detected in melanomas.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000032:analysis / Q000556:secondary; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000032:analysis*; D009508:Nevus, Pigmented / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis* / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
Récepteurs cestrogéniques et progestéroniques dans les mélanomes malins, les naevi pigmentaires bénins et les épithéliomas baso-cellulaires.