Intestinal absorption of aluminum in rats: effect of intraluminal pH and aluminum concentration.
The intestinal absorption of aluminum (Al) was studied in an in situ perfusion system of rat small intestine in combination with systemic and portal blood sampling. The jejunum-ileum was perfused with media containing 4.63, 9.25 and 18.50 mmol l-1 Al chloride at pH 4.0 and 7.0. Both mucosal retention was not affected by pH but at lower pH more Al was released into the blood. The amount of Al which appeared in the blood was linearly related to the mucosal retention. The Al release into the blood was much less (mumol l-1) than the mucosal retention (mmol l-1). It is concluded that the intestinal absorption of Al is pH- and concentration-dependent.
D000535:Aluminum / Q000097:blood / Q000378:metabolism*; D000818:Animals; D005260:Female; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism; D010477:Perfusion; D011168:Portal System; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000535:Aluminum