title: Evidence of abnormality of lymphocyte uroporphyrinogen synthase in family members of patients with lymphoproliferative diseases.
abstract: Patients with active lymphoproliferative diseases (LPD) were shown to have high activity of lymphocyte uroporphyrinogen synthase (L-UROS), the enzyme which converts porphobilinogen to uroporphyrinogen. The mean L-UROS activity of 64 first-degree relatives of patients with LPD was significantly higher than that of a control group and 45% of these relatives had pathological values of L-UROS. L-UROS activity was also determined in the spouses of 2 patients and was pathologically elevated in both. The pattern of pathological values among family members may indicate the presence of a communicable agent.
mesh_terms: D000328:Adult; D000368:Aged; D000642:Ammonia-Lyases / Q000097:blood*; D005260:Female; D006689:Hodgkin Disease / Q000201:enzymology / Q000235:genetics; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood*; D011163:Hydroxymethylbilane Synthase / Q000097:blood*; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000235:genetics; D008214:Lymphocytes / Q000201:enzymology*; D008223:Lymphoma / Q000201:enzymology / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000201:enzymology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014576:Uroporphyrinogen III Synthetase / Q000097:blood*
chemical_list: D011163:Hydroxymethylbilane Synthase; D006836:Hydro-Lyases; D014576:Uroporphyrinogen III Synthetase; D000642:Ammonia-Lyases