Low plasma pyridoxal-5'-phosphate levels in children with the nephrotic syndrome.
Of 35 children with the nephrotic syndrome in relapse, 88% were found to have low circulating plasma pyridoxal-5'-phosphate (PLP) levels. Remission of the syndrome was associated with spontaneous normalization of plasma PLP levels in 23 such children. A significant (P less than 0,001) positive correlation (r = 0,81) was found between plasma albumin and PLP levels and a significant (P less than 0,001) negative correlation (r = -0,66) between plasma PLP and serum cholesterol levels. The low plasma PLP levels may be due to enhanced urinary excretion of albumin-bound PLP in view of the severe proteinuria which characterizes the nephrotic syndrome.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood*; D011732:Pyridoxal Phosphate / Q000097:blood*; D012075:Remission, Spontaneous; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin; D011732:Pyridoxal Phosphate; D002784:Cholesterol