title: A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein.
abstract: A mutant Rauscher spleen focus-forming virus (mutant 4-3) that causes mild splenic erythroblastosis in mice has a 44-base-pair deletion in the 3' region of its envelope glycoprotein (env) gene. The encoded glycoprotein terminates prematurely, lacks a hydrophobic membrane anchor, and has a shortened intracellular lifespan. An active site for causing erythroblast proliferation may occur in the undamaged amino-terminal domain of the env glycoprotein.
mesh_terms: D001483:Base Sequence; D002872:Chromosome Deletion; D004900:Erythroblasts / Q000473:pathology; D006023:Glycoproteins / Q000032:analysis*; D009154:Mutation; D011925:Rauscher Virus / Q000235:genetics* / Q000472:pathogenicity; D013154:Spleen / Q000473:pathology; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000235:genetics
chemical_list: D006023:Glycoproteins; D014759:Viral Envelope Proteins