title: Contrast media-induced nephrotoxicity. Survey and present state.
abstract: Reports of renal failure induced by contrast media are increasing. Adverse effects of contrast media on kidney function include diuresis, changes in renal blood flow, osmotic nephroses, albuminuria, enzymuria and, most important, glomerular filtration rate. Animal studies indicate that the new nonionic contrast medium, iohexol, has fewer adverse effects on kidney function than the ionic media currently used. Three clinical studies offer some evidence of the effect of iohexol on renal function, but it is not yet possible to conclude that lower nephrotoxicity found in animals will also be found in man. Further clinical studies are warranted, and careful monitoring of contrast media clearance is recommended in all high-risk patients.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000419:Albuminuria / Q000139:chemically induced; D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D003973:Diatrizoate / Q000633:toxicity; D004231:Diuresis / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007472:Iohexol; D007668:Kidney / Q000187:drug effects; D008793:Metrizamide / Q000633:toxicity; D008794:Metrizoic Acid / Q000633:toxicity; D009401:Nephrosis / Q000139:chemically induced; D012079:Renal Circulation / Q000187:drug effects; D014283:Triiodobenzoic Acids / Q000633:toxicity
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007472:Iohexol; D003404:Creatinine; D008794:Metrizoic Acid; D008793:Metrizamide