title: Lesions of experimental flea bite hypersensitivity in the dog.
abstract: Hypersensitivity to fleas was induced in flea-naive dogs by controlled challenge exposure to virgin fleas. By week 10 of the investigation, immediate (15 minute) and delayed (24-48 hours) responses could be elicited in the skin by flea bites. Histologically, the immediate response consisted of edema and eosinophils which sometimes overlapped with a delayed inflammatory response comprised of perivascular lymphocytes and fewer histiocytes. These inflammatory patterns correlated with type I or immediate, and type IV or cellular, allergic reactions. The combined immediate and delayed responses to fleas in the dog are as observed by other investigators in man and guinea pigs.
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004487:Edema / Q000473:pathology / Q000662:veterinary*; D004804:Eosinophils / Q000166:cytology; D006968:Hypersensitivity, Delayed / Q000473:pathology / Q000662:veterinary*; D006969:Hypersensitivity, Immediate / Q000473:pathology / Q000662:veterinary*; D007299:Insect Bites and Stings / Q000473:pathology / Q000662:veterinary*; D008214:Lymphocytes / Q000166:cytology; D008407:Mast Cells / Q000166:cytology; D009504:Neutrophils / Q000166:cytology; D005423:Siphonaptera; D012867:Skin / Q000473:pathology