Acute non-lymphocytic leukemia following multimodality therapy for retinoblastoma.
The genetic form of retinoblastoma carries a high risk of secondary malignant neoplasm, apparently not related to the use of chemotherapy. A child with unilateral non-genetic retinoblastoma who had received chemotherapy and radiation therapy and developed acute non-lymphocytic leukemia (ANLL) is reported. The occurrence of ANLL and retinoblastoma has not been previously reported.
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure*; D002675:Child, Preschool; D002872:Chromosome Deletion; D003131:Combined Modality Therapy / Q000009:adverse effects; D005134:Eye Neoplasms / Q000628:therapy*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000209:etiology* / Q000235:genetics; D010198:Pancytopenia / Q000209:etiology; D012175:Retinoblastoma / Q000628:therapy*