title: Immunization of guinea-pigs and cattle with a reduced dose Clostridium chauvoei vaccine produced in a semi-synthetic medium.
abstract: A semi-synthetic culture medium and method are described for the production of a reduced dose Clostridium chauvoei vaccine. The vaccine gave excellent results in guinea-pigs, and 2 injections of 2.0 ml protected cattle against challenge with 2 M.L.D. of a virulent culture for at least 12 months. The suitability of C. chauvoei Strain OP64 as a vaccine strain was confirmed.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000592:standards*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control; D003013:Clostridium / Q000276:immunology*; D003015:Clostridium Infections / Q000517:prevention & control / Q000662:veterinary*; D003470:Culture Media; D006168:Guinea Pigs; D013997:Time Factors; D014611:Vaccination / Q000662:veterinary
chemical_list: D001428:Bacterial Vaccines; D003470:Culture Media