Subclasses of olfactory receptor cells and their segregated central projections demonstrated by a monoclonal antibody.
A library of monoclonal antibodies (MAbs) was generated against a homogenate of the rabbit olfactory bulb. One of them immunohistochemically distinguished a subgroup of olfactory nerves. Both in the olfactory bulb and the epithelium, this MAb labeled most olfactory receptor axons in the lateral but only a small fraction in the medial portion. These findings demonstrate a molecular heterogeneity among olfactory receptor cells and suggest a functional division between the lateral and the medial portions of the epithelium and the bulb.
D000818:Animals; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D009830:Olfactory Bulb / Q000166:cytology* / Q000276:immunology; D009831:Olfactory Mucosa / Q000294:innervation*; D009832:Olfactory Nerve / Q000166:cytology*; D009833:Olfactory Pathways / Q000276:immunology; D011984:Sensory Receptor Cells / Q000166:cytology* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens