[In vivo activity of drug-metabolizing enzymes in various pathological conditions].
Activity of enzymes, metabolizing drugs, was studied in acute kidney insufficiency and acute purulent peritonitis of rabbits using antipyrine test. In these pathological states the antipyrine half-life was increased and clearance was decreased, thus demonstrating the inhibition of drug-metabolizing enzymes. The data obtained suggest that the antipyrine test may exhibit the rate of drug metabolism in pathological conditions.
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D000983:Antipyrine / Q000378:metabolism; D001711:Biotransformation; D006207:Half-Life; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008657:Metabolic Clearance Rate; D008862:Microsomes, Liver / Q000201:enzymology; D010538:Peritonitis / Q000201:enzymology* / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011817:Rabbits
D004364:Pharmaceutical Preparations; D000983:Antipyrine
Izuchenie in vivo aktivnosti fermentov, metaboliziruiushchikh lekarstvennye veshchestva, pri nekotorykh patologicheskikh sostoianiiakh.