Iron mobilization from ferritin using alpha-oxohydroxy heteroaromatic chelators.
Several alpha-oxohydroxy heteroaromatic chelators have been shown to mobilize iron from horse spleen ferritin. Although the reactions were slow, taking up to 3 days to reach completion, the amounts of iron mobilized were higher than those reported for other chelators. These results increase the prospects for the clinical use of alpha-oxohydroxy chelators in the treatment of iron overload.
D002614:Chelating Agents; D000077543:Deferiprone; D003676:Deferoxamine / Q000494:pharmacology; D003956:Dialysis; D005293:Ferritins / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007659:Ketones / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology; D011753:Pyrones / Q000494:pharmacology; D013053:Spectrophotometry
D002614:Chelating Agents; D007659:Ketones; D011728:Pyridones; D011753:Pyrones; C048216:1-methyl-3-hydroxypyridine-2-one; D000077543:Deferiprone; C008316:maltol; D005293:Ferritins; D007501:Iron; D003676:Deferoxamine