title: Comparison of the morbidity of tetanus toxoid boosters with tetanus-diphtheria toxoid boosters.
abstract: A double-blind randomized trial was performed to compare the subjective morbidity of tetanus toxoid (T) with that of tetanus-diphtheria toxoid (Td). Symptoms occurred in 46 (48%) of 93 patients who received T, and in 75 of 100 patients who received Td (chi 2 = 12.3; P less than .001). The effectiveness of immunization is clear, but with shift from use of T to Td as recommended, adherence to immunization guidelines and taking of adequate immunization histories becomes even more important.
mesh_terms: D000328:Adult; D004168:Diphtheria Toxoid / Q000009:adverse effects*; D022422:Diphtheria-Tetanus Vaccine; D004311:Double-Blind Method; D004338:Drug Combinations / Q000009:adverse effects; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D010146:Pain / Q000139:chemically induced; D011897:Random Allocation; D013745:Tetanus Toxoid / Q000009:adverse effects*
chemical_list: D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D013745:Tetanus Toxoid