title: [Secretion of organic acids and bases by the kidneys of marine teleosts].
abstract: In the experiments performed on kidneys of 5 species of marine Teleostei, morphological peculiarities in secretion of 8 fluorescent organic acids (uranin, primulin, tripaphlavin, erythrosin etc.) and in 5 organic bases (rhodamin C, auramin etc.) have been studied. At a very low concentration in the incubation medium--about 0.005 mg/ml--the substances mentioned penetrate into the epithelial cell of the canaliculus; its weak fluorescence appears, and soon they begin to be excreted in great amount through the apical part of the plasmolemma and accumulated in the canalicular lumen. All the substances studied accumulate in the cell and only some of them (uranin, primulin, titanic yellow, etc.) are secreted into the canalicular lumen. Penicillinum and probenecide inhibit penetration of the organic acids into the cell through the basal membrane. Uranin secretion into the canalicular lumen is inhibited in the presence of furocemid; amilorid, magnium and sulfate ions do not influence secretion of the organic acids. Secretion of the organic bases does not change when paraaminohippuric acid and furocemid are added to the medium, but it decreases when concentration of magnium ions increases.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D004232:Diuretics / Q000494:pharmacology; D005399:Fishes / Q000378:metabolism*; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D066298:In Vitro Techniques; D007684:Kidney Tubules / Q000378:metabolism*; D008278:Magnesium Sulfate / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D013045:Species Specificity; D010130:p-Aminohippuric Acid / Q000494:pharmacology
chemical_list: D004232:Diuretics; D005452:Fluoresceins; D008278:Magnesium Sulfate; D019793:Fluorescein; D010130:p-Aminohippuric Acid
vernacular_title: Sekrestiia organicheskikh kislot i osnovaniĭ pochkoĭ morskikh kostistykh ryb.