Tuberoinfundibular dopaminergic system and anterior pituitary dopamine receptor in Shy-Drager syndrome.
Tuberoinfundibular dopaminergic system (TIDA) together with anterior pituitary dopamine receptor was evaluated in 9 patients with Shy-Drager syndrome (SDS) through the responses of serum growth hormone (GH) and prolactin (PRL) to dopaminergic stimulation or dopamine receptor inhibition. A variety of abnormal responses of serum GH and/or PRL following the administration of these drugs suggests the TIDA involvement as well as the nigrostriatal system and moreover the different degeneration processes in each dopaminergic system in SDS.
D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D001971:Bromocriptine; D004298:Dopamine / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D011388:Prolactin / Q000097:blood; D011954:Receptors, Dopamine / Q000502:physiology*; D012791:Shy-Drager Syndrome / Q000503:physiopathology*; D013469:Sulpiride
D011954:Receptors, Dopamine; D001971:Bromocriptine; D013469:Sulpiride; D011388:Prolactin; D013006:Growth Hormone; D004298:Dopamine