Bile acid metabolism during development: metabolism of taurodeoxycholic acid in human fetal liver.
The metabolism of tauro-[24-14C]deoxycholic acid was studied in microsomal preparations from fetal liver. The livers were obtained at legal abortions performed between week 13 and 24. Taurodeoxycholic acid was efficiently hydroxylated in the 1 beta- and 7 alpha-positions. The hydroxylase activities did not increase with gestational age. A marked variation in extent of hydroxylation was noted between different preparations. The results are discussed in relation to earlier knowledge of fetal and neonatal bile acid metabolism.
D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000196:embryology* / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D013656:Taurocholic Acid / Q000096:biosynthesis; D013657:Taurodeoxycholic Acid / Q000378:metabolism*
D003840:Deoxycholic Acid; D013657:Taurodeoxycholic Acid; D013656:Taurocholic Acid