Roles of coronary circulation as a determinant of the left ventriculo-arterial interaction.
We investigated how coronary circulation influences the ventriculo-arterial interaction. For the quantitative analysis of this interaction, we proposed a simple framework where both ventricular property and vascular property were expressed as the end-systolic pressure-volume relationship. Combining this analysis with experimental data indicated the interactive nature of ventricular function that varied with loading condition through coronary circulation. Effects of regional ischemia on the ventriculo-arterial interaction was also analyzed. The loading condition insensitivity, simplicity and adequacy of the end-systolic pressure-volume relationship of ventricle made it possible to analytically couple the ventricle with arterial system providing a useful view in understanding the complex hydraulic interaction between the ventricle and arterial system.
D016275:Atrial Function; D001794:Blood Pressure; D002302:Cardiac Output; D003326:Coronary Circulation; D006321:Heart / Q000502:physiology*; D008955:Models, Cardiovascular; D013318:Stroke Volume; D014655:Vascular Resistance; D016276:Ventricular Function