Satellite DNA in the three C-bands of an unusual mouse marker chromosome. A model of chromosomal evolution.
A marker chromosome in the stemline of a new murine cell line is described on the basis of different stainings and in situ hybridization. The marker was characterized originally by three C-bands, one from each centromeric region of the three chromosomes constituting the marker. In the course of stemline evolution, two of the C-bands have been lost and the marker has developed into a monocentric chromosome, phenotypically and functionally normal.
D000818:Animals; D005075:Biological Evolution; D002460:Cell Line; D002871:Chromosome Banding; D002875:Chromosomes / Q000032:analysis* / Q000648:ultrastructure; D004276:DNA, Satellite / Q000032:analysis*; D006570:Heterochromatin / Q000032:analysis; D007621:Karyotyping; D051379:Mice; D009693:Nucleic Acid Hybridization
D004276:DNA, Satellite; D006570:Heterochromatin