Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac.
The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D020910:Ketorolac; D051379:Mice; D008968:Molecular Conformation; D011758:Pyrroles; D051381:Rats; D013237:Stereoisomerism; D014046:Tolmetin / Q000031:analogs & derivatives
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011758:Pyrroles; D014046:Tolmetin; D020910:Ketorolac