Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement.
Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.
D000818:Animals; D001345:Autoradiography; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004699:Endocardium / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006346:Heart Septum / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005227:Fatty Acids; D019788:Fluorodeoxyglucose F18; C033637:3-methylheptadecanoic acid; D003847:Deoxyglucose; D005947:Glucose