Effects of rifampin pretreatment on hepatic parameters in the rabbit.
Rifampin pretreatment in the rabbit caused a selective induction of hepatic parameters resembling in some respects phenobarbital induction. Concomitant with induction, a transient selective inhibition of hepatic parameters was also observed. This two-fold effect of rifampin offers an explanation for the discrepancy surrounding the dosage and species differences in hepatic induction reported in the literature.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology*; D013997:Time Factors
D006899:Mixed Function Oxygenases; D012293:Rifampin; D010634:Phenobarbital