title: Oral and dental development in X chromosome aneuploidy.
abstract: Though frequently noted, orofacial anomalies in poly X syndromes have been seldom reviewed. In a study of patients with an X chromosome aneuploidy (XXXXX, XXXX, XXXXY, XXXY) the following facial and dental defects were found to be characteristic features of these syndromes: mainly bifid uvula and macroglossia, enamel defects, dental taurodontism and abnormal roots. These observations are discussed in the light of the possible role of X-linked genes.
mesh_terms: D000293:Adolescent; D000782:Aneuploidy; D002648:Child; D003743:Dental Enamel / Q000002:abnormalities; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D007621:Karyotyping; D008260:Macroglossia / Q000235:genetics*; D008297:Male; D011596:Psychomotor Disorders / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D013577:Syndrome; D014071:Tooth Abnormalities / Q000235:genetics*; D014609:Uvula / Q000002:abnormalities*; D014960:X Chromosome