Single dose prophylaxis with metronidazole in infants during abdominal surgery: a pharmacokinetic study.
Plasma metronidazole was measured following a single intravenous dose of 20 mg/kg (Flagyl 5 mg/ml) in 12 infants less than 1 year of age undergoing abdominal surgery. In all patients sufficient plasma concentrations, well above the MIC values for anaerobic bacteria, were found for at least 16 h. A prolonged half-life was demonstrated in the group less than 8 weeks of age (t1/2/18.4 h). The group over 8 weeks of age demonstrated a t1/2 comparable to that seen in adults (t1/2 7 h).
D000005:Abdomen / Q000601:surgery*; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
D008795:Metronidazole