The effect of alpha-solanine on the active calcium transport in rat intestine.
Solanine, an alkaloid isolated from potatoes was found to inhibit active calcium transport in rat duodenum both when added to the everted intestine sacs in vitro and when given to the rats in drinking water for 12 days. The inhibition by solanine of the active calcium transport in the rat intestine was found to be noncompetitive, the inhibitory constant being 25 microM.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012992:Solanine / Q000494:pharmacology*
D012992:Solanine; D002118:Calcium