Nifedipine in exercise-induced asthma.
The calcium entry blockers may inhibit EIA in patients with bronchial asthma, but it is not demonstrated that they produced bronchodilation once the crisis is established. Nine patients with exercise induced asthma were studied. We carried out an exercise test for ten minutes with constant load and the following were measured; FVC, PEF, MEF25 and sGaw before and after test. All the values fell 20% or more than the initial values. A 20 mg was administered without modifying the studied parameters and only the administration of 400 micrograms of metaproterenol by inhalation made the sensation of dyspnea recur in all patients.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004341:Drug Evaluation; D005080:Exercise Test; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D009921:Metaproterenol; D009543:Nifedipine / Q000627:therapeutic use*; D012129:Respiratory Function Tests
D009921:Metaproterenol; D009543:Nifedipine