A 2p;11q chromosome translocation in dysmyelopoietic preleukemia.
Three patients with dysmyelopoietic preleukemia had a marrow clone with translocation t(2;11)(p21;q23) as the only chromosome change. In one patient, the cytogenetically altered cells disappeared following treatment with 13-cis-retinoic acid. Although these patients did not constitute a homogeneous clinical subgroup, the 2p;11q translocation should probably be added to the short list of nonrandom karyotypic alterations involving 11q23 that have been described in various hematopoietic disorders.
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011289:Preleukemia / Q000235:genetics*; D014178:Translocation, Genetic