Effect of dexamethasone on polypeptides synthesised in polymorphonuclear leucocytes.
The effect of a glucocorticoid on protein synthesis in human polymorphonuclear leucocytes (PMNLs) was investigated by two-dimensional gel electrophoresis. In the peripheral blood PMNLs of healthy laboratory personnel, the rate of incorporation of L-[35S]methionine into a least nine polypeptides was consistently influenced by dexamethasone in a dose-dependent manner, being increased in the case of seven polypeptides and decreased in the remainder.
D001798:Blood Proteins / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007525:Isoelectric Focusing; D008715:Methionine / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*
D001798:Blood Proteins; D003907:Dexamethasone; D008715:Methionine