Histological examination of combined effects of chemotherapeutical agents and differently fractionated irradiations in transplanted solid Ehrlich carcinoma of mice. I. Observations after adriamycin treatment.
4 X 3 mg/kg body weight adriamycin treatment induced histological damages in solid Ehrlich carcinoma, which increased on the effect of the parallel applied 10 X 5 Gy dose local fractionated X-ray irradiation. Comparing the effect of differently fractionated irradiations of the same total dose combined with adriamycin treatment, it can be stated that daily given less radiation fractions induce more severe damage than relatively higher ones applied in three to four days interval.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000628:therapy*; D002452:Cell Count / Q000187:drug effects / Q000528:radiation effects; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000379:methods; D004317:Doxorubicin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D009336:Necrosis; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D013997:Time Factors
D004317:Doxorubicin