Effect of administration of carnitine on the severity of myocardial infarction induced by isoproterenol in rats.
The effect of administration of carnitine on the severity of myocardial infarction in rats induced by isoproterenol was studied by following histopathological and biochemical parameters. Carnitine afforded partial protection against myocardial infarction. Serum aspartate amino transferase (GOT) and creative phospho kinase (CPK) values, serum, heart and aortic lipids, serum protein-bound hexose and sialic acid and glycosaminoglycans in the heart were lower in the carnitine-treated rats. Histopathological examination showed very little necrosis in the carnitine-treated rats when compared to the extensive necrosis in the untreated controls.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002331:Carnitine / Q000494:pharmacology*; D002784:Cholesterol / Q000032:analysis; D003402:Creatine Kinase / Q000097:blood; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006601:Hexoses / Q000032:analysis; D007545:Isoproterenol / Q000633:toxicity*; D008929:Mitochondria, Heart / Q000378:metabolism; D009203:Myocardial Infarction / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000032:analysis; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000032:analysis; D013997:Time Factors; D014280:Triglycerides / Q000032:analysis
D005227:Fatty Acids; D006025:Glycosaminoglycans; D006601:Hexoses; D012794:Sialic Acids; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D007545:Isoproterenol; D002331:Carnitine