[Effect of enkephalins on the function of the calcium-regulating endocrine glands in shock].
The experiments on white rats weighing 180-220 g have shown that in traumatic and hemorrhagic shock the initial increase in parathyroid hormone blood concentration is followed by the decrease of functional activity of parathyroid glands. Calcitonin concentration is found to increase during the first hours of shock. The changes in calcium-regulating gland function result in significant disturbances of calcium exchange during shock. The injection of synthetic leu-enkephalin analogs to rats with shock leads to normalization of calcium-regulating endocrine glands function.
D000818:Animals; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000097:blood*; D004353:Drug Evaluation, Preclinical; D004702:Endocrine Glands / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy*; D012774:Shock, Traumatic / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors
D010281:Parathyroid Hormone; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D002116:Calcitonin; D002118:Calcium; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie énkefalinov na funktsiiu kal'tsiĭreguliruiushchikh éndokrinnykh zhelez pri shoke.