title: Renal effects of aluminium in uraemic rats and in rats with intact kidney function.
abstract: The effect on renal function following administration of aluminium (i.p., five times weekly (0.05 or 0.5 mg kg-1 body weight) for 12 weeks) to partially nephrectomized (5/6 NX) or intact female rats was examined. The observed loss of concentrating ability, characterized by increased urine volume and an increased sodium excretion, as well as increased renal excretion of p-aminohippurate (demonstrable after low-dose treatment with nephrotoxins) can be interpreted as an initiation of kidney function injury. No distinct differences in response were observed between partially nephrectomized and intact animals.
mesh_terms: D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D001835:Body Weight; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007671:Kidney Concentrating Ability / Q000187:drug effects; D009392:Nephrectomy; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D014511:Uremia / Q000503:physiopathology* / Q000652:urine; D010130:p-Aminohippuric Acid
chemical_list: D012964:Sodium; D000535:Aluminum; D011188:Potassium; D010130:p-Aminohippuric Acid