Conjunctival involvement with mycosis fungoides in a patient receiving PUVA therapy.
A 40-year-old woman had documented mycosis fungoides of the skin. Over a period of five years, she had undergone intermittent treatment with psoralen long-wave ultraviolet light (PUVA) therapy. Despite regression of the skin lesions, tumor plaques developed in her eyelid and conjunctiva within the area shielded by dark glasses. Light and electron microscopic examination of a biopsy from the conjunctival plaque confirmed that the lesion was a deposit of mycosis fungoides. Local radiotherapy resulted in complete regression of these ocular lesions. The conjunctiva may well be an iatrogenic "sanctuary site" when this disease is treated with PUVA therapy.
D000328:Adult; D003228:Conjunctiva / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000139:chemically induced* / Q000473:pathology; D005142:Eyelid Neoplasms / Q000139:chemically induced; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D009182:Mycosis Fungoides / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D011701:PUVA Therapy / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D011247:Pregnancy; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology