title: Erythema annulare centrifugum as the presenting sign of the hypereosinophilic syndrome: observations on therapy.
abstract: A 79-year-old man with severe generalized pruritus and erythema annulare centrifugum as manifestations of his idiopathic hypereosinophilic syndrome slowly responded to long-term therapy with ketoconazole and dapsone. The skin lesions cleared within one month but the pruritus and eosinophilia required seven full months of therapy.
mesh_terms: D000368:Aged; D003622:Dapsone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004802:Eosinophilia / Q000150:complications* / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D013577:Syndrome; D013997:Time Factors
chemical_list: D003622:Dapsone; D007654:Ketoconazole