[Cellular composition and ultrastructure of the thymus of the newborn mouse after immunization of pregnant females with homologous brain antigens].
Immunization is performed with 20% of water-saline extract of medulla oblongata on the 6th, 8th, 10th days of pregnancy (1 g per 200 g body mass). In the thymus cortical substance of newborn rats no statistically significant difference in content of small lympocytes, lymphoblasts and large lymphocytes, mitotically deviding cells is revealed as compared to the normal. The part of middle lymphocytes decreases up to 5.7 +/- 0.7% (control--10.0 +/- 1.7%). The content of distroying cells and fagocytic macrophages is increasing. In cytoplasm of one macrophage several fagocyted degenerating cells with pyknotic nuclei and destructively altered organells are often present. In the interlobular connective tissue an increased amount of degenerating forms of mast cells is noted. In the thymus medullary substance small lymphocytes are growing in number. Certain changes in vessels of the microcirculatory bed are revealed.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002452:Cell Count; D005260:Female; D008214:Lymphocytes / Q000166:cytology; D008407:Mast Cells / Q000166:cytology; D008431:Maternal-Fetal Exchange; D008854:Microscopy, Electron; D011247:Pregnancy; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000648:ultrastructure
Kletochnyĭ sostav i ul'trastruktura timusa novorozhdennykh krys pri immunizatsii beremennykh samok antigenami gomologichnogo mozga.