[Experimental evaluation of the the possible use of 99mTc- and 133mIn-labelled aminomethylene phosphonates for skeletal scintigraphy].
The pharmacokinetics of 99mTc and 113mIn labeled aminopolymethyl phosphonic acids was studied in experiments on animals. Noticeable osteotropism of these compounds was shown. Scans of the rabbit and rat skeleton in health and experimental pathology 1 h after i.v. administration of these compounds were obtained making it possible to reveal the affected foci.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000378:metabolism; D007204:Indium / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism; D011817:Rabbits; D011868:Radioisotopes / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D013997:Time Factors
D009943:Organophosphorus Compounds; D011868:Radioisotopes; D007204:Indium; D013667:Technetium
Eksperimental'naia otsenka vozmozhnosti ispol'zovaniia aminometilenfosfonatov, mechennykh 99mTc i 133mIn, dlia stsintigrafii skeleta.