title: Management of preterm prematurely ruptured membranes: a prospective randomized comparison of observation versus use of steroids and timed delivery.
abstract: The use of hydrocortisone and timed delivery was compared to expectant management of pregnancies complicated by preterm prematurely ruptured membranes in a prospective randomized trial of 73 patients. The incidence of maternal and neonatal complications was compared. There was no significant difference in the incidence of respiratory distress syndrome. Steroid-treated mothers had an increased incidence of postpartum febrile morbidity. We conclude that treatment of women with preterm prematurely ruptured membranes with hydrocortisone and timed delivery offers no advantage over expectant management.
mesh_terms: D000293:Adolescent; D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000188:drug therapy*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D007226:Infant Mortality; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000453:epidemiology / Q000209:etiology; D007743:Labor, Obstetric; D007970:Leukopenia / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000209:etiology; D013997:Time Factors
chemical_list: D006854:Hydrocortisone