Effect of intraventricular putrescine on adenosylmethionine decarboxylase in rat hypothalamus and caudate nucleus.
Effects of intracerebroventricularly injected putrescine on adenosylmethionine decarboxylase activity in rat hypothalamus and caudate nucleus were studied. Doses that lacked the capacity to produce behavioral and electrocortical epileptogenic disorder caused a significant activation of enzyme occurring between 10 and 15 min after injection. The changes in hypothalamic and caudate nucleus enzyme activity after putrescine administration were dose-dependent, and they supported the assumption that limiting putrescine concentration in vivo may play a role in adenosylmethionine decarboxylase regulation.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism*; D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D002421:Caudate Nucleus / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D007031:Hypothalamus / Q000201:enzymology*; D007276:Injections, Intraventricular; D007700:Kinetics; D011700:Putrescine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase; D011700:Putrescine