Pathogenesis of postmyelographic arachnoiditis.
The causal relationship between a myelogram with an aqueous contrast medium and postmyelographic arachnoiditis has not been clarified. Primates after myelography with metrizamide or meglumine iocarmate were studied with fluorescent microscopy, energy dispersion analysis and with scanning and transmission electron and light microscopy. All controls and, up to the eighth day after myelography, all treated animals had normal-appearing arachnoid membranes by microscopy. After eight days the treated animals had progressively more severe arachnoid fibrosis. Energy dispersive analysis revealed iodine in the arachnoid only up to 24 hours after myelography. Fluorescent microscopy revealed no evidence of immune complexes in the arachnoid. The chronic effects of water-soluble media on the arachnoid are not apparently mediated by contrast medium persisting in the arachnoid or by immune complexes.
D000818:Animals; D001099:Arachnoid / Q000473:pathology; D001100:Arachnoiditis / Q000139:chemically induced* / Q000473:pathology; D003287:Contrast Media / Q000633:toxicity*; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D008251:Macaca; D008536:Meglumine / Q000633:toxicity*; D008793:Metrizamide / Q000633:toxicity*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D009192:Myelography / Q000009:adverse effects*; D013012:Sorbitol / Q000031:analogs & derivatives*; D013997:Time Factors
D003287:Contrast Media; D007483:Iothalamic Acid; C025504:iocarmate meglumine; D013012:Sorbitol; D008536:Meglumine; D008793:Metrizamide