Protective effect of the flavonoid silybin dihemisuccinate on the toxicity of phenylhydrazine on rat liver.
Phenylhydrazine is a hemolytic agent whose mechanism of action is related with the formation of free radicals and the induction of lipid peroxidation. The flavonoid silybin dihemisuccinate is an antihepatotoxic principle used in the treatment of many liver diseases; its mechanism of action has been ascribed to its antioxidant properties. This work demonstrates, using a hemoglobin-free perfusion system, the protective effect of the in vivo treatment of the rat with silybin dihemisuccinate on the hepatic glutathione depletion and lipid peroxidation induced by the infusion of phenylhydrazine into the perfusion buffer.
D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010659:Phenylhydrazines / Q000494:pharmacology* / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D000077385:Silybin; D012838:Silymarin / Q000031:analogs & derivatives / Q000494:pharmacology*
D005419:Flavonoids; D008054:Lipid Peroxides; D010659:Phenylhydrazines; D012838:Silymarin; C030299:phenylhydrazine; D000077385:Silybin; D008315:Malondialdehyde; C038266:silybin dihemisuccinate; D005978:Glutathione