[Initiation of unscheduled synthesis on DNA sites associated with a nuclear matrix of irradiated hepatoma cells].
A study was made of the distribution of unscheduled DNA synthesis (induced by UV- or gamma-radiation and resistant to hydroxyurea) between the DNA sites in the nuclear matrix and total nuclear DNA of Zajdela ascites hepatoma cells. It was shown that during the first 1.5 to 5 min of the postirradiation incubation the rate of the unscheduled synthesis of DNA was considerably higher in the DNA fraction, firmly associated with the nuclear matrix proteins, than in the total nuclear DNA.
D000818:Animals; D002460:Cell Line; D003037:Cobalt Radioisotopes; D004260:DNA Repair / Q000528:radiation effects*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005720:Gamma Rays; D066298:In Vitro Techniques; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D014466:Ultraviolet Rays
D003037:Cobalt Radioisotopes; D004273:DNA, Neoplasm
Ob initsiatsii vneplanovogo sinteza na uchastkakh DNK, assotsiirovannykh s iadernym matriksom obluchennykh kletok gepatomy.