Osmosin and ileal ulceration: a case report.
A 78-year-old woman presented with an acute abdomen and was found to have a perforation of her terminal ileum. She did not survive the post-operative period and at necropsy was found to have numerous ulcers of the ileum. In the ulcerated areas there was a transmural chronic inflammatory infiltrate, but no evidence of granulomata. We believe that this ulceration was caused by ingestion of Osmosin tablets containing indomethacin and suggest a possible pathogenesis.
D000368:Aged; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D007213:Indomethacin / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced* / Q000473:pathology
D003692:Delayed-Action Preparations; D007213:Indomethacin