[The role of vitamin E in the biosynthesis of the isoprenoid region of the ubiquinone molecule in the rat liver].
A decrease in the CoA and acetyl-CoA amount in the rat liver tissue by 34.8 and 29.4%, respectively, as well as inhibition of the biosynthesis rate of mevalonic acid from [I-14C] acetyl-CoA in the postmitochondrial liver fraction by 17.9% as compared to the control are found against a background of E-hypovitaminosis. The last change is not associated with the inhibition of the 3-oxy-3-methylglutaryl-CoA-reductase activity and may not be one of reasons which cause the biosynthesis disturbances in the isoprenoid part of the ubiquinone molecule in this organ. alpha-Tocopherol activates the ubiquinone biosynthesis from [2-14C] sodium acetate in the liver of rats with E-hypovitaminosis under conditions of 30 min preincubation and is not efficient when added in combination with actinomycin D. Probably, such an effect of alpha-tocopherol is realized at the level of RNA synthesis and is associated with the biosynthesis activation of short-living RNA.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D005260:Female; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008798:Mevalonic Acid / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000378:metabolism*; D014451:Ubiquinone / Q000096:biosynthesis*; D014810:Vitamin E / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000201:enzymology / Q000378:metabolism
D013729:Terpenes; D014451:Ubiquinone; D014810:Vitamin E; D000105:Acetyl Coenzyme A; D008798:Mevalonic Acid
Izuchenie roli vitamina E v biosinteze izoprenoidnoĭ chasti molekuly ubikhinona v pecheni krys.