Dihydroergotoxine decreases blood pressure in spontaneously hypertensive rats by interacting with peripheral dopamine receptors.
Dihydroergotoxine (10 micrograms/kg s.c.) decreased mean carotid blood pressure in urethane-anaesthetized spontaneously hypertensive rats but failed to modify the same parameter in normotensive rats. The effect was statistically significant 20 min after the injection and relatively long lasting (up to 90 min). Pharmacological characterization of the phenomenon indicated that it is mediated by stimulation of dopamine receptors, since pretreatment with haloperidol, cis-flupentixol but not with trans-flupentixol, completely prevent the reduction in blood pressure induced by dihydroergotoxine. Moreover, a challenge dose of dihydroergotoxine did not reduce mean blood pressure values in spontaneously hypertensive rats pretreated with domperidone or (-)sulpiride, but not with (+)sulpiride. These results suggest that the ergot derivative modifies the cardiovascular system by interaction with peripheral dopamine receptors of the DA2 type.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004294:Domperidone / Q000494:pharmacology; D004347:Drug Interactions; D005475:Flupenthixol / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011920:Rats, Inbred WF; D011954:Receptors, Dopamine / Q000378:metabolism*; D013997:Time Factors
D011954:Receptors, Dopamine; D004088:Dihydroergotoxine; D004294:Domperidone; D005475:Flupenthixol; D006220:Haloperidol