HLA antigens, jejunal morphology and associated diseases in children with dermatitis herpetiformis.
Forty-five Hungarian and Finnish children from 1.5 to 15 years with dermatitis herpetiformis were studied for HLA antigens, jejunal morphology on gluten-containing diet and associated diseases in the patients and their relatives. A strong association with HLA-B8 was found in patients of both nationalities, the relative risks were 12.8 and 9.6, respectively. The Hungarian patients were also typed for HLA-DR locus, and an association with DR3 but not with DR7 was observed. Patients with subtotal villous atrophy had slightly more often HLA-B8 and DR3 than those with milder intestinal lesions. Atopic eczema occurred in 20% of the patients and family history of atopy seemed to have an inverse correlation with HLA-B8 and DR3.
D000293:Adolescent; D001284:Atrophy; D002446:Celiac Disease / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D005387:Finland; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D006814:Hungary; D006969:Hypersensitivity, Immediate; D007223:Infant; D007583:Jejunum / Q000473:pathology*; D008297:Male; D012306:Risk
D006680:HLA Antigens