Deficits in manipulative behaviors induced by local injections of muscimol in the first somatosensory cortex of the conscious monkey.
Injection of muscimol (GABA agonist) in the finger region of area 2 of the alert monkey led to the striking yet reversible loss of finger coordination, thus disabling the monkey from picking up a small piece of food from a small hole or a funnel. Symptoms varied depending on sites of injection within the finger region. Neither weakness of hand or finger movements nor deficit in hand reach was observed.
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology; D001931:Brain Mapping; D005260:Female; D006225:Hand; D008251:Macaca; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid