[Changes in the metabolism of chondrocytes after chronic intake of phenol and lead].
White rats and guinea pigs were given phenol (0.2 and 10 mg/kg) or lead acetate (10 mg/kg of the body mass) for 3-6 months. Intensity of biosynthesis was estimated by glycosaminoglycane cells and by collagene (by means of 35S and 3H-glycine inclusion), distribution of glycoproteids, glycogene and alcaline phosphomonoesterase. The intensity of glycosaminoglycanes biosynthesis decrease in chondrocytes, as does glycogene content and alcaline phosphomonoesterase activity in the zones of the cartilage mineralization. In the intercellular cartilage substance, sertain deviations in quantity and in artio of different types of macromolecules appear, that results in decreasing rates of the cartilage substitution and of the osseous trabecules growth and in development of osteoporosis.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002356:Cartilage / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D005998:Glycine / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis*; D006132:Growth Plate / Q000378:metabolism; D006168:Guinea Pigs; D007855:Lead Poisoning / Q000378:metabolism*; D019800:Phenol; D010636:Phenols / Q000506:poisoning*; D011509:Proteoglycans / Q000378:metabolism; D051381:Rats; D013431:Sulfates / Q000378:metabolism
D006025:Glycosaminoglycans; D010636:Phenols; D011509:Proteoglycans; D013431:Sulfates; D019800:Phenol; D006003:Glycogen; D003094:Collagen; D000469:Alkaline Phosphatase; D005998:Glycine
Izmeneniia metabolizma khondrotsitov pri khronicheskom postuplenii v organizm fenola i svintsa.