Hyperthermic effect of neurotensin in the rabbit.
Neurotensin injected into the anterior hypothalamus of the rabbit induces a consistent upward shift of the threshold core temperatures for inducing cold thermogenesis, peripheral vasomotor tone and respiratory evaporative heat loss, while leaving the efficiency and the intensity of these thermoregulatory outputs unchanged. Neurotensin injections into the PH are without effect on body temperature control. The effect of neurotensin is interpreted as a selective inhibition of activity of warm sensors in the anterior hypothalamus. The possible mediating role of dopaminergic pathways in the neurotensin action is discussed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D005260:Female; D005334:Fever / Q000139:chemically induced*; D007032:Hypothalamus, Anterior / Q000187:drug effects; D007034:Hypothalamus, Posterior / Q000187:drug effects; D007035:Hypothermia; D007276:Injections, Intraventricular; D007422:Intestines / Q000502:physiology; D008660:Metabolism / Q000187:drug effects; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012881:Skin Temperature / Q000187:drug effects
D009496:Neurotensin