Oral submucous fibrosis--treatment with hyalase.
Oral Submucous Fibrosis (OSMF) is a disease of unknown etiology. A total of 96 patients with Oral Submucous Fibrosis have received four regimens of treatment--local dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. The patients were followed up for a period varying from 3 months to 2 years. The group of patients receiving hyaluronidase alone showed quicker improvement in symptoms although its combination with dexamethasone gave somewhat better longer-term results. A new regimen for the treatment of submucous fibrosis is recommended.
D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000627:therapeutic use*; D009059:Mouth Diseases / Q000188:drug therapy*; D009914:Oral Submucous Fibrosis / Q000188:drug therapy*; D010924:Placental Extracts / Q000627:therapeutic use; D011897:Random Allocation; D013997:Time Factors
D010924:Placental Extracts; D003907:Dexamethasone; D006821:Hyaluronoglucosaminidase