Decreased sensitivity to insulin in women with microprolactinomas.
To determine whether there exists an altered sensitivity to insulin in hyperprolactinemia, we studied, in 15 women with microprolactinomas, the insulin effects on glucose, PRL, GH, and cortisol before and after successful adenoma removal. Our results show that in women with microprolactinomas, the sensitivity to insulin is lower in hyperprolactinemia than in normoprolactinemia achieved by selective adenomectomy.
D000236:Adenoma / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006966:Hyperprolactinemia / Q000503:physiopathology* / Q000601:surgery; D007333:Insulin Resistance; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
D001786:Blood Glucose; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone