Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.
The ability of nucleoside permeants to accelerate the efflux of uridine from human erythrocytes has been compared. In contrast to uridine, 2-chloroadenosine acted as a trans-inhibitor of uridine efflux from fresh human erythrocytes, and adenosine had little effect. These results are consistent with the lower maximum velocity for influx of 2-chloroadenosine and adenosine as compared with uridine and demonstrate that trans acceleration experiments do not discriminate between transported and non-transported permeants for the human erythrocyte nucleoside carrier.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology*; D014529:Uridine / Q000097:blood* / Q000494:pharmacology
D009705:Nucleosides; D015762:2-Chloroadenosine; D000241:Adenosine; D014529:Uridine