A role for Ca2+ in the effect of very low frequency electromagnetic field on the blastogenesis of human lymphocytes.
The DNA synthesis of lymphocytes triggered by phytohemagglutinin or phorbol-myristate-acetate is strongly reduced by the externally applied electromagnetic field (ELF). Ca2+ uptake by stimulated lymphocytes is also reduced by ELF. The effect appears to be synergistic with that of the well-known calcium blocker agent, verapamil.
D002118:Calcium / Q000378:metabolism*; D055590:Electromagnetic Phenomena; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014700:Verapamil / Q000494:pharmacology
D010835:Phytohemagglutinins; D014700:Verapamil; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium; D013936:Thymidine