title: Age associated alteration of lidocaine metabolism is position selective.
abstract: Patterns of associated alterations in N-deethylation, 3-hydroxylation, and aromatic methylhydroxylation of a single substrate, lidocaine in liver microsomes from 0.7 - 28 months old Fischer 344 rats were examined. These three patterns were all different from one another. In addition to this position selectiveness, a clear sex difference was observed in the pattern of alteration in N-deethylation. These results are consistent with the hypothesis that age associated alterations in drug metabolism are caused by age associated alterations in relative abundance of multiple species of cytochrome P-450.
mesh_terms: D000375:Aging; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D008012:Lidocaine / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013329:Structure-Activity Relationship
chemical_list: D008012:Lidocaine