[Systemic hemodynamic changes during the development of DOCA-salt hypertension. The effect of neonatal sympathectomy].
The elevation of the cardiac index was discovered at the initial stage of DOCA-salt hypertension in rats. The blood pressure rise at the stage of stable hypertension was caused by an increase in the total peripheral vascular resistance. Neonatal sympathectomy prevented the development of DOCA-salt hypertension and elevation of the cardiac index revealed in control sympathectomized rats.
D000818:Animals; D000831:Animals, Newborn; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006145:Guanethidine; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D009392:Nephrectomy; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D013563:Sympathectomy, Chemical; D013997:Time Factors
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D006145:Guanethidine
Izmenenie sistemnoĭ gemodinamiki v protsesse razvitiia DOKA-solevoĭ gipertenzii. Vliianie neonatal'noĭ simpatéktomii.