[Effect of estradiol and other endocrine factors on the level and dynamics of estrogen receptors in the liver cells of rats].
The authors studied the effects of different doses of estradiol (E2) on the level of estrogen receptors (ER) in female rat hepatocytes and the dynamics of ER distribution between the cytosol and nuclear cell fractions and compared the changes in the ER level in the liver in different endocrine states of the body. It was shown that the ER level in hepatocytes was far lower than in uterine cells and drastically increased during puberation and after ovariectomy. It was also found that the ER level in hepatocytes was dependent on pituitary functions. After a single injection of E2, the ER level in cytosol descended and that in the nucleus rose. The degree of ER reduction in cytosol and increase in the nucleus correlated with the dose of E2. The dynamics of intercombined changes in the levels of cytosol and nuclear ER was studied at different time intervals following the injection of different doses of the hormone. Some essential organ-specific features of E2 reception in the liver were revealed. Different mechanisms of the control of ER content in the liver and uterus are postulated.
D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000187:drug effects; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003600:Cytosol / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007016:Hypophysectomy; D008099:Liver / Q000187:drug effects*; D009928:Organ Specificity / Q000187:drug effects; D051381:Rats; D011960:Receptors, Estrogen / Q000032:analysis / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D006063:Chorionic Gonadotropin; D011960:Receptors, Estrogen; D004958:Estradiol
Vliianie éstradiola i drugikh éndokrinnykh faktorov na uroven' i dinamiku éstrogennykh retseptorov v kletkakh pecheni krys.