Further investigation of the role of progesterone in the control of embryo transport in the mouse.
Combined ovariectomy and adrenalectomy retarded mouse embryo transport while either operation alone did not. Serum progesterone levels were reduced after ovariectomy and after the combined operation but detectable levels were still present on Day 4 following both procedures. Embryo transport was also retarded after administration of testosterone propionate. This effect was abolished by progesterone and was not mimicked by 5 alpha-dihydrotestosterone. From these results it is concluded that progesterone influences embryo transport and that androgenic effects are probably a result of antagonism of progesterone.
D000315:Adrenalectomy; D000818:Animals; D002369:Castration; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010066:Ovum Transport / Q000187:drug effects; D011374:Progesterone / Q000097:blood / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology
D013739:Testosterone; D011374:Progesterone