An unusual Donath-Landsteiner antibody detectable at 37 degrees C by the antiglobulin test.
A 14-year-old boy with no history of transfusion experienced a hemolytic crisis attributed to paroxysmal cold hemoglobinuria. The Donath-Landsteiner test was positive. The IgG autoantibody had anti-P specificity but was unique in that it also reacted strongly by indirect antiglobulin test at 37 degrees C.
D000293:Adolescent; D001323:Autoantibodies / Q000032:analysis*; D001789:Blood Group Antigens / Q000276:immunology*; D001831:Body Temperature; D003298:Coombs Test; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood; D006461:Hemolysis; D006801:Humans; D008297:Male; D010127:P Blood-Group System / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies; D001789:Blood Group Antigens; D010127:P Blood-Group System