Guanabenz therapy for opiate withdrawal.
A 29-year-old man used codeine approximately 1000 mg/d for seven years prior to detoxification. He developed dose-related clonidine side effects of dizziness, sedation, and dysphoria during standard clonidine detoxification; however, opiate withdrawal symptoms persisted. Conversion to guanabenz, a clonidine-like alpha 2 agonist, promptly relieved the opiate withdrawal symptoms without side effect recurrence. Guanabenz shows promise as an opiate withdrawal agent.
D000328:Adult; D003000:Clonidine / Q000009:adverse effects; D003061:Codeine / Q000009:adverse effects*; D006143:Guanabenz / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D006146:Guanidines; D006143:Guanabenz; D003000:Clonidine; D003061:Codeine