Isolation and characterization of lipocortin (lipomodulin).
Lipocortin is a phospholipase inhibitory protein whose synthesis is induced in various cells by glucocorticoids. At least three species with molecular weights of 40,000, 30,000, and 15,000 are presently known. This protein mimics the anti-inflammatory action of glucocorticoids in vitro as well as in vivo. The synthesis of the protein appears to be associated with the MHC genes.
D000818:Animals; D017302:Annexins; D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D002135:Calcium-Binding Proteins; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006023:Glycoproteins / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology; D066298:In Vitro Techniques; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D011817:Rabbits
D017302:Annexins; D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D002135:Calcium-Binding Proteins; D006023:Glycoproteins; C030958:lipomodulin; D010741:Phospholipases A