Interaction of morphine and naloxone with mixed monolayers of lecithin and gangliosides.
Monomolecular films of lecithin, gangliosides or lecithin/gangliosides mixtures were studied on a Langmuir through in order to examine the interactions between these lipids and opioid agonists or antagonists. Lecithin alone did not interact in a monolayer structure with opioids. However, gangliosides and lecithin/gangliosides mixtures were expanded by both morphine and naloxone. The expansion of ganglioside-containing monolayers was greater with morphine than with the antagonist, naloxone.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005732:Gangliosides; D009020:Morphine; D009270:Naloxone; D010713:Phosphatidylcholines
D005732:Gangliosides; D010713:Phosphatidylcholines; D009270:Naloxone; D009020:Morphine