[Ribamidil as a modulator of the toxic effect of 5-fluorouracil].
The in vitro experiments on CaOv cells demonstrated that ribamidyl (ribavirine) (Rb) enhances the intracellular pool of pyrimidine precursors of DNA. This was the basis for studies of its modifying effect on the antitumour activity of antimetabolites. In experiments with intact hybrid mice F1 (CBA+C57B1) the five times administration of ribavirine increase sharply the toxicity of 5-FU. The data should be taken into consideration when combining Rb with antimetabolites in clinical practice.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012254:Ribavirin / Q000627:therapeutic use*; D012263:Ribonucleosides / Q000627:therapeutic use*
D004273:DNA, Neoplasm; D012263:Ribonucleosides; D012254:Ribavirin; D005472:Fluorouracil
Ribamidil kak moduliator toksicheskogo éffekta 5-ftoruratsila.