Hepatic delta 6-desaturase activity in lean and genetically obese ob/ob mice.
Hepatic delta 6-desaturase activity is primarily located in the mitochondrial fraction in mice. Both delta 6- and delta 5-desaturase activities are increased in the liver of young (6-week-old) obese mice. The increase in hepatic delta 6-desaturase activity in obese mice does not occur until weaning. Neither restriction of food intake nor hyperinsulinaemia normalize hepatic delta 6-desaturase activity of obese mice. Both cold acclimation and tri-iodothyronine (30 micrograms/day per kg) decreased hepatic delta 6-desaturase activity of obese mice to levels observed in lean mice, whereas the increase in activity in obese mice was still maintained after the induction of hypothyroidism.
D000818:Animals; D001921:Brain / Q000201:enzymology; D044943:Fatty Acid Desaturases / Q000378:metabolism*; D005502:Food; D007037:Hypothyroidism / Q000201:enzymology; D050602:Linoleoyl-CoA Desaturase; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008820:Mice, Obese; D008930:Mitochondria, Liver / Q000201:enzymology; D009765:Obesity / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology; D013696:Temperature; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D044943:Fatty Acid Desaturases; C000616952:delta-6 desaturase, mouse; D050602:Linoleoyl-CoA Desaturase