Localized intestinal perforations after enteral administration of indomethacin in premature infants.
Four very-low-birth-weight infants developed localized intestinal perforations after enteral administration of indomethacin. The clinical picture and histologic findings were unlike those seen in necrotizing enterocolitis.
D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000473:pathology; D007441:Intubation, Gastrointestinal; D007579:Jejunal Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D007213:Indomethacin