title: Pertussis epidemic in Oklahoma. Difficulties in preventing transmission.
abstract: From Jan 1 to Dec 31, 1983, 351 cases of pertussis were reported in Oklahoma. Overall, 59% of the cases were among children 3 months to 6 years of age, the target age group for pertussis vaccination; only 42% of the patients in this age group were appropriately immunized for age with diphtheria and tetanus toxoids and pertussis vaccine (DTP). A survey of 185 households in the neighborhoods of three cases found that only 65% of 57 children 3 months to 6 years of age were appropriately immunized for their age. Aggressive control of the outbreak was attempted in Oklahoma County with recommendations for widespread vaccination against pertussis. However, the effort failed to immunize 82% of the 931 children in the initial target group. Nonetheless, analysis of the reported cases suggested that less than one fourth of the cases were potentially preventable by a single additional dose of DTP, ie, in individuals 3 months to 6 years of age with a history of at least one prior dose of DTP who were not appropriately immunized for age. The optimal solution to outbreak control is outbreak prevention by ensuring that the maximal number of children younger than 7 years of age receive routine age-appropriate DTP vaccination.
mesh_terms: D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000517:prevention & control; D004168:Diphtheria Toxoid; D004196:Disease Outbreaks / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007114:Immunization; D007223:Infant; D009825:Oklahoma; D010567:Pertussis Vaccine; D014917:Whooping Cough / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission
chemical_list: D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine