A bovine epithelial membrane protein that binds polymeric immunoglobulin and has a structure related to that of bovine secretory component.
A protein of Mr 94000 was isolated from detergent-solubilized bovine intestinal, liver and mammary-gland membranes. It binds immunoglobulin M and also undergoes proteolytic fragmentation in a similar manner to bovine secretory component (Mr 74000). The affinity-purified membrane protein is therefore most likely to be the bovine epithelial receptor for polymeric immunoglobulin. A structural model is proposed.
D000818:Animals; D002417:Cattle; D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000032:analysis*; D005260:Female; D007075:Immunoglobulin M / Q000378:metabolism*; D008565:Membrane Proteins / Q000276:immunology; D008954:Models, Biological; D010446:Peptide Fragments / Q000032:analysis
D007075:Immunoglobulin M; D008565:Membrane Proteins; D010446:Peptide Fragments