Genetic control of the resistance to spontaneous immunocytoma (plasmacytoma-IR tumour) development in LOU/C rats.
Immunocytomas (immunoglobulin secreting tumours) appear with a highly spontaneous incidence in animals of the inbred LOU/C strain but never in those of the inbred OKA strain. Congenic rats with LOU/C genetic background, having either the heavy or the kappa light immunoglobulin chain loci from the OKA strain, have an immunocytoma incidence similar to that of the LOU/C strain. The congenic strain, having the major histocompatibility complex of the OKA strain on the LOU/C background, showed no immunocytoma incidence. These results indicate that the MHC locus of the rat, or a gene closely linked to it, determines resistance to immunocytoma development. Specific chromosomal translocation associated with Ig gene chromosome and c-myc play a major role in the origin of the rat IR tumours. These experiments show that the resistance of the OKA strain to the appearance of IR tumours is not correlated with special properties of Ig heavy and kappa gene segments.
D000818:Animals; D002430:Cecal Neoplasms / Q000235:genetics / Q000276:immunology; D002460:Cell Line; D007078:Ileal Neoplasms / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate; D007136:Immunoglobulins / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000235:genetics* / Q000276:immunology; D010954:Plasmacytoma / Q000235:genetics* / Q000276:immunology; D051381:Rats
D007136:Immunoglobulins