Immunological studies on the cerebrospinal fluid in neurological sarcoidosis.
The rate of intrathecal IgG synthesis and the degree of permeability of the blood-brain barrier in 5 patients with sarcoidosis involving the central nervous system are described. Intrathecal IgG synthesis was unusual but increased leakiness of the blood-brain barrier was common in these patients; a finding which may help differentiate such cases from patients with multiple sclerosis.
D000418:Albumins / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000276:immunology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000134:cerebrospinal fluid* / Q000276:immunology
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D007136:Immunoglobulins; D005947:Glucose