title: HLA antigens-antibodies system and its association with severe toxemia of pregnancy.
abstract: HLA antigens and antibodies were investigated in order to study the relationship between severe toxemia of pregnancy (toxemia) and the HLA system, which is in a close relationship with the immune response. The frequencies of 8 HLA-A antigens, 21 HLA-B antigens, 10 HLA-DR antigens and 4 HLA-MT antigens were determined in 21 patients with toxemia and their husbands and some of their children, 45 fertile couples without a history of abnormal pregnancy and 206 healthy adult controls (DR were in 106 controls). Sera from toxemias and normal pregnant women in the 3rd. trimester and postpartum intra-uterine blood in women with normal deliveries were tested for Warm-T and Warm-B cell antibody against 30 panel lymphocytes. Results obtained were as follows: In toxemic couples there is a much higher incidence of HLA-DR and MT sharing between wives and husbands, mothers and children. In those sera with toxemias, there is a higher incidence of Warm-T antibody and a lower incidence of Warm-B antibody compared with those with a normal pregnancy. From the immunogenetic point of view, when the HLA-DR X MT locus of a certain fetus is homozygous, the mother tends to manifest toxemia. These results indicated that matching of HLA-DR X MT loci in parents possibly plays a role in causing severe toxemia, and genetic prediction of its onset and prognosis can be carried out through HLA typing.
mesh_terms: D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies