Chromosome 12 rearrangement with breakage at the p11 level in hematologic disorders: report of four cases.
Four patients with chromosome #12 rearrangement at the p11 level are described. One had acute promyelocytic leukemia, one had myelofibrosis evoluting to acute undifferentiated leukemia, one had acute nonlymphoid leukemia (ANLL) secondary to Hodgkin's disease, and another had acute leukemia recurring after allogeneic bone marrow transplantation. This chromosome abnormality was always associated with other karyotypic aberrations, probably as a secondary event. Possible correlations with recent findings in oncogene research are discussed.
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000235:genetics*