title: Ganglioside headgroups decrease lipid order in reconstituted phosphatidylcholine liposomes.
abstract: The effect of oligosaccharide carrying lipids on membrane fluidity has been investigated. Gangliosides GM1 and GQ1 were reconstituted into phosphatidylcholine bilayer membranes at low concentrations (less than 5 mol%). A strong fluidizing effect was observed leading to a suppression of the phase transition temperature. This was most pronounced with highly sialylated gangliosides. Ca2+ reverses the effect due to phase separation phenomena. We assume a hydrophilic lipid-lipid interaction in accordance with previously studied glycoprotein-lipid interactions.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D055598:Chemical Phenomena; D002621:Chemistry; D005732:Gangliosides / Q000302:isolation & purification; D008081:Liposomes; D008560:Membrane Fluidity; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship; D013552:Swine; D013816:Thermodynamics
chemical_list: D005732:Gangliosides; D008081:Liposomes; D010713:Phosphatidylcholines