title: Polymer resins with amino acid containing pendants for sorption of bilirubin. II. Polyamide resins with various basic amino acids.
abstract: Short peptides, three to eight amino acids in length, containing various combinations of alanine, arginine, lysine, histidine and tyrosine have been synthesized onto water-swellable polyamide resin by the solid phase peptide synthesis method. The amount of bilirubin adsorbed from aqueous buffer solution (pH = 7.8) by the resins increases with increasing basicity of the amino acids in the pendant. As the number of basic amino acids on the pendant is increased from one to five a 4.7 fold enhancement in the adsorption capacity is seen for arginine while a 9.3 fold enhancement is obtained for lysine. A corresponding increase in length for the non-basic histidine results in a 6 fold enhancement. With alanine the adsorption capacity is uneffected by an increase in pendant length.
mesh_terms: D000409:Alanine; D000818:Animals; D001663:Bilirubin / Q000097:blood*; D002417:Cattle; D002792:Cholestyramine Resin; D006464:Hemoperfusion / Q000379:methods*; D009757:Nylons; D009842:Oligopeptides
chemical_list: D009757:Nylons; D009842:Oligopeptides; D002792:Cholestyramine Resin; D000409:Alanine; D001663:Bilirubin