title: Problems and results in testing the possible general mode of action of glucocorticoids in rat adjuvant arthritis.
abstract: The antiinflammatory action of dexamethasone in both phases of rat adjuvant arthritis was significantly reduced by injection of the RNA synthesis inhibitor actinomycin D into the inflamed paw. This effect is apparently caused by inhibition of RNA/protein synthesis and not by actinomycin D irritant activity. Thus, the present data support the view of indirect glucocorticoid activity via gene expression also in subacute and chronic adjuvant arthritis. The dexamethasone-induced antiinflammatory protein seems to be synthetized at the site of inflammation.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000517:prevention & control*; D001169:Arthritis, Experimental / Q000473:pathology / Q000517:prevention & control*; D002351:Carrageenan; D003609:Dactinomycin / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005938:Glucocorticoids; D003609:Dactinomycin; D003907:Dexamethasone; D002351:Carrageenan