Intercellular communication capacity as a possible determinant of transformation sensitivity of BALB/c 3T3 clonal cells.
While clonal cell variants of BALB/c 3T3 with high and low susceptibilities to ultraviolet radiation- and benzo(a)pyrene-induced transformation show similar intercellular communication capacities when they are in the growing phase, a significant loss in communication occurs at confluence only in transformation-sensitive clonal variant cells. A potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, which also enhances BALB/c 3T3 cell transformation induced by methylcholanthrene, inhibited intercellular communication of these variants to a similar extent. These results suggest that intrinsic differences in the control of intercellular communication may be a determinant of the susceptibility of these variants to the induction of transformation.
D000818:Animals; D002450:Cell Communication; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000648:ultrastructure*; D002999:Clone Cells / Q000166:cytology*; D003847:Deoxyglucose / Q000378:metabolism; D004351:Drug Resistance; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D008748:Methylcholanthrene; D003847:Deoxyglucose; D013755:Tetradecanoylphorbol Acetate