Synergistic deleterious effects of nitrous oxide exposure and vitamin B12 deficiency.
Rats raised on a vitamin B12-deficient or -sufficient diet were either exposed or not exposed to nitrous oxide for 3 hours before sacrifice. Bone marrow cells were assayed for thymidylate synthetase activity by the deoxyuridine suppression test. A synergistic interaction between vitamin B12 deficiency and nitrous oxide exposure was observed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects*; D001856:Bone Marrow Examination; D004247:DNA / Q000378:metabolism; D003857:Deoxyuridine / Q000032:analysis / Q000378:metabolism*; D004347:Drug Interactions; D008297:Male; D009609:Nitrous Oxide / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
D004247:DNA; D009609:Nitrous Oxide; D014805:Vitamin B 12; D003857:Deoxyuridine