First-trimester drug use and congenital disorders.
The authors determined the prevalence of certain major congenital disorders among live-born infants of 6509 mothers in a prepaid health plan for the 30-month period of January 1, 1980 through June 30, 1982 who used a wide variety of drugs during the first trimester of pregnancy. The results were similar to those obtained in this population in a prior 30-month study. No strong associations between any of the commonly used drugs and the congenital disorders studied were present.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D001977:Brompheniramine / Q000009:adverse effects; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology; D004025:Dicyclomine; D004319:Doxylamine / Q000009:adverse effects; D004338:Drug Combinations / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010656:Phenylephrine / Q000009:adverse effects; D010665:Phenylpropanolamine / Q000009:adverse effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D054199:Pseudoephedrine; D011736:Pyridoxine / Q000009:adverse effects; D014861:Washington
D004338:Drug Combinations; C007484:brompheniramine, pseudoephedrine drug combination; C004454:dicyclomine, doxylamine, pyridoxine drug combination; D010656:Phenylephrine; D010665:Phenylpropanolamine; D004025:Dicyclomine; D054199:Pseudoephedrine; D004319:Doxylamine; D001977:Brompheniramine; D011736:Pyridoxine