The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes.
High glutathione transferase activity towards trans-stilbene oxide has been observed in resting mononuclear leukocytes only in a portion of the individuals examined. Approximately 46% of a population of 248 individuals demonstrated this high activity. In addition, eight families have been investigated in order to elucidate the hereditary transmission of this activity. The results are consistent with a dominant expression of a single gene located on an autosomal chromosome for this high glutathione transferase activity.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005799:Genes, Dominant; D005982:Glutathione Transferase / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000201:enzymology*; D010375:Pedigree; D010641:Phenotype; D013267:Stilbenes / Q000378:metabolism*
D013267:Stilbenes; D005982:Glutathione Transferase; C025906:stilbene oxide