Determination of impurities in nucleoside 3'-phosphoramidites by fast atom bombardment mass spectrometry.
Negative-ion fast atom bombardment mass spectrometry is quite useful for the identification of products and by-products formed during the synthesis of nucleoside 3'-phosphoramidites. The data show that detritylation and oxidation are side reactions which occur during the synthesis of monomeric units used in the construction of oligodeoxyribonucleotides by the phosphite triester method.
D000577:Amides / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D013058:Mass Spectrometry / Q000379:methods*; D009711:Nucleotides / Q000032:analysis*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000032:analysis*
D000577:Amides; D009711:Nucleotides; D009838:Oligodeoxyribonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid