title: Some insect sensory neurones contain 5-hydroxytryptamine.
abstract: Immunocytochemistry of the locust central nervous system shows that most segmental nerves, in particular those of the legs, contain afferent fibres that react with antibody to 5-hydroxytryptamine (5-HT). Adsorption controls indicate that the antigen is 5-HT or a closely related compound. This is supported by the finding of significant amounts of 5-HT in leg nerves using reverse phase high-performance liquid chromatography (HPLC) and electrochemical detection. On the other hand 5-HT was not detectable in locust antennal and cercal nerves with either immunocytochemistry or with HPLC. These results strongly support that some populations of sensory neurones in the locust contain 5-HT.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry / Q000379:methods; D005724:Ganglia / Q000378:metabolism*; D006110:Grasshoppers / Q000032:analysis / Q000378:metabolism*; D009475:Neurons, Afferent / Q000378:metabolism; D012701:Serotonin / Q000032:analysis / Q000378:metabolism*
chemical_list: D012701:Serotonin