Naltrexone facilitation of sexual receptivity in the rat.
Naltrexone hydrochloride (3mg/kg) facilitated sexual receptivity in ovariectomized female rats given estradiol benzoate 44 hr previously. The latency of naltrexone facilitation is 3 hr, which is similar to that by progesterone. Other doses of naltrexone (1 and 5 mg/kg) were ineffective. Unlike the effect of progesterone, the facilitation of behavior by naltrexone is not blocked by the protein synthesis inhibitor anisomycin. Naltrexone facilitation was blocked by pargyline, a monoamine oxidase inhibitor.
D000315:Adrenalectomy; D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D002369:Castration; D004347:Drug Interactions; D004723:Endorphins / Q000502:physiology; D005260:Female; D009270:Naloxone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D011187:Posture; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology
D004723:Endorphins; D009270:Naloxone; D009271:Naltrexone; D000841:Anisomycin; D010293:Pargyline