[Pharmacologic activity of tert-aminoalkyl derivates of quinoxalinone, aza- and diaza-quinoxalinone].
Eight tert-aminoalkyl derivatives of 3-methyl-6R-quinoxalin-2-one, 3-methyl-6/8-azaquinoxalin-2-ones and 3-methyl-6,8-diazaquinoxalin-2-one, previously selected for their deconditioning activity in rats were now tested in mice for analgesic, explorative and incoordinating (muscle relaxant) activities; acute toxicity was also determined. Several compounds show a good degree of activity in the tests used.
D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000588:Amines; D000700:Analgesics; D009125:Muscle Relaxants, Central; D011810:Quinoxalines
Attività farmacologica di terz-amminoalchilderivati di chinossalinoni aza- e diaza-chinossalinoni.