A statistical examination of historical controls for mouse bone marrow cytogenetic assays.
Data from 1,111 controls from assays run over 11 years are examined to determine a most powerful statistical procedure for detecting a mutagenic effect. It is concluded that the data do not show a constant probability of chromosomal abnormalities and that the data do not fit a simple Poisson or binomial distribution. Empirical Bayes techniques are used to derive a test that declares an effect if three or more cells in a group of 50 tested contain abnormalities.
D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure*; D002869:Chromosome Aberrations / Q000187:drug effects*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D013223:Statistics as Topic; D013997:Time Factors
D009153:Mutagens