Chemotherapeutically active anthraquinones. II. Aminomethylanthraquinones.
Basically substituted 2,6- and 2,7-bis-amino-methylanthraquinones have a pronounced in vitro and in vivo effect against Entamoeba hystolytica (extraintestinal amoebiasis in golden hamsters) and marked interferon-inducing properties. In 2,6- and 2,7-bis-aminomethyl-anthraquinones only the introduction of hydroxyl groups in 1,5 or 1,8 position led to an additional high systemic activity against Trichomonas foetus in NMRI mice, but it also resulted in the loss of the interferon-inducing effect. Both substance classes included several compounds whose effects against E. histolytica or T. foetus were either comparable or superior to those of standard compounds ornidazole and tinidazole.
D000562:Amebiasis / Q000188:drug therapy; D000656:Amoeba / Q000187:drug effects; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology* / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D007369:Interferon Inducers; D008647:Mesocricetus; D051379:Mice; D014244:Trichomonas / Q000187:drug effects; D014245:Trichomonas Infections / Q000188:drug therapy
D000880:Anthraquinones; D000981:Antiprotozoal Agents; D007369:Interferon Inducers