[Effect of ethanol on the DNA-polymerase activity in the liver subcellular fractions of adult and old rats].
The effect of 5% ethanol on DNA polymerase activity in nuclei, mitochondria, microsomes and cytosol of intact and regenerating liver of adult and old rats has been studied. No changes in DNA polymerase activity were detected in subcellular fractions of adult rat liver. On the contrary, the increased activity of intact liver nuclei and decreased activity of regenerating liver microsomes was observed with ageing. These age-dependent peculiarities of DNA polymerase activity in response to 5% ethanol may be related to changes in the enzyme molecules or microenvironment associated with ageing.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008115:Liver Regeneration / Q000187:drug effects; D019384:Nucleic Acid Synthesis Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology
D019384:Nucleic Acid Synthesis Inhibitors; D000431:Ethanol; D004259:DNA-Directed DNA Polymerase
Vliianie étanola na DNK-polimeraznuiu aktivnost' v subkletochnykh fraktsiiakh pecheni vzroslykh i straykh krys.