Effects of topical epinephrine on experimental sickle cell hyphema.
Experimental sickle cell hyphemas were produced by injecting human sickle cell-beta(0)-thalassemia blood into rabbit anterior chambers. Eyes treated with topical 2% epinephrine hydrochloride showed no significant difference in the duration of the hyphema or in the percentage of sickled cells in the anterior chamber compared with untreated eyes. Topical 2% epinephrine had no apparent sustained effect on intraocular pressure.
D000755:Anemia, Sickle Cell / Q000097:blood*; D000818:Animals; D004195:Disease Models, Animal; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006988:Hyphema / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011817:Rabbits; D013997:Time Factors
D009883:Ophthalmic Solutions; D004837:Epinephrine