[Kinetics of Streptomyces baarnensis growth and antibiotic synthesis in batch and dialysis cultures].
The kinetics of biomass and antibiotic formation in batch and dialysis culture of Streptomyces baarnensis at various initial concentrations limiting the substrate growth (glucose) has been studied. The antibiotic substances were synthesized by actively growing culture, its concentration in the cultural media was maximum in the log-phase. In continuous dialysis culture on the background of biomass lianer growth in the course of time the constant antibiotic concentration in the media proportional to the glucose input concentration has been established. The inactivation (decomposition) of antibiotic was immediately initiated after discontinuation of substrate supply and followed first kinetics order. Observed features were used for construction of kinetical model of antibiotic biosynthesis. A conclusion has been made that the dialysis culture gives opportunity for more effective antibiotic synthesis as compared with the batch one.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media / Q000378:metabolism; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D012988:Soil Microbiology; D013302:Streptomyces / Q000254:growth & development* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003470:Culture Media; D005947:Glucose
Kinetika rosta Streptomyces baarnensis i sintez antibiotika v periodicheskoĭ i dializnoĭ kul'turakh.