Cephalothin and penicillin G polymers as elicitors of rat PCA mediated by mouse IgE antibodies.
PCA-eliciting activities of cephalothin- and penicillin G-polymers were examined in rats sensitized with homologous IgE antibodies of mouse origin. Cephalothin-polymers elicited PCA regardless of the source of antibodies and the methods to raise them, the minimal effective dose being 2 to 20 micrograms/animal. Penicillin G-polymers provoked PCA only when anti-benzylpenicilloyl IgE antibody of C57BL/6J mouse raised early after immunization was used. The minimal effective dose in this case was 5 micrograms/animal, being comparable to that of cephalothin polymers.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002512:Cephalothin / Q000494:pharmacology*; D005260:Female; D007073:Immunoglobulin E / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010400:Penicillin G / Q000494:pharmacology*; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D011108:Polymers; D007073:Immunoglobulin E; D010400:Penicillin G; D002512:Cephalothin