title: Topical anaesthetic and tear film stability.
abstract: The effect of unpreserved topical anaesthetic on tear film stability (0.4% oxybuprocaine hydrochloride) was investigated in a double masked randomised study in 12 healthy volunteers, using a noninvasive tear film break up technique (NIBUT). It was found that the topical anaesthetic did not reduce the pre-corneal tear film stability, contrary to the electron microscopic evidence.
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D011343:Procaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011897:Random Allocation; D012965:Sodium Chloride / Q000494:pharmacology; D013666:Tears / Q000187:drug effects*
chemical_list: D000779:Anesthetics, Local; D009883:Ophthalmic Solutions; D012965:Sodium Chloride; D011343:Procaine; C005298:benoxinate