Warfarin absorption after massive small bowel resection.
Small bowel resection is often accompanied by malabsorption and nutritional deficiencies. Malabsorption of drugs may also occur; however, few reports have been published. We treated five patients with oral warfarin for thrombotic problems after substantial small bowel resection. All five had a documented hypoprothrombinemic response to the warfarin (patient prothrombin time: control greater than 1.5). Maintenance warfarin doses were up to 10 mg/day. Oral warfarin appears to be well absorbed after removal of the majority of the jejunum and ileum. This may indicate a proximal site of warfarin absorption.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time; D013923:Thromboembolism / Q000188:drug therapy; D014859:Warfarin / Q000378:metabolism* / Q000627:therapeutic use
D014859:Warfarin