Plasma concentrations of clonazepam after single rectal administration.
Clonazepam was administered rectally to six children aged 1.4 to 4.7 years in a dose of 0.05 mg/kg and to five children aged 1.4 to 4.1 years in a dose of 0.1 mg/kg. Plasma concentrations indicate that it is rapidly absorbed, and it may therefore be an alternative to rectal administration of diazepam in continuing convulsions.
D001570:Benzodiazepinones / Q000008:administration & dosage*; D002675:Child, Preschool; D002998:Clonazepam / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D007267:Injections; D008297:Male; D012007:Rectum; D003294:Seizures, Febrile / Q000188:drug therapy*
D001570:Benzodiazepinones; D002998:Clonazepam