Reduced binding of basic somatomedin by mouse placental membranes following maternal alcohol administration.
The effects of 3 days of maternal ethanol administration on the placenta and on basic somatomedin (B-SM) were investigated in the mouse. Following administration of aqueous ethanol by gavage on days 13, 14 and 15 of gestation, there was no treatment-related difference in embyonic growth or placental weight as seen on day 15. There was a significant reduction in the specific binding of [125I]B-SM by day 15 placental membranes, but no difference in serum B-SM concentrations or in the frequency or severity of degenerative changes in the placenta. We have shown that changing levels of serum B-SM over the normal course of pregnancy correspond closely to patterns of cellular proliferation and aging in the placenta. It is possible that impairment in the binding activity of B-SM receptors contributes to the premature aging observed in term placentas exposed to alcohol during pregnancy in the rodent.
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D008861:Microsomes / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011485:Protein Binding; D012098:Reproduction / Q000187:drug effects; D013002:Somatomedins / Q000378:metabolism*
D013002:Somatomedins; D000431:Ethanol