Linkage and recombination between fragile X-linked mental retardation and the factor IX gene.
Linkage analysis on a family with fragile X-linked mental retardation was performed using a Taq 1 restriction fragment length polymorphism detected by a cloned human coagulation factor IX cDNA. Two affected brothers in this sibship were found to have different factor IX RFLP alleles, indicating a recombinational event occurred between the two genes. Our data therefore indicate that the gene responsible for fragile X-linked mental retardation is not as tightly linked to the factor IX gene as the previously published data may suggest.
D000483:Alleles; D004274:DNA, Recombinant; D005164:Factor IX / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations / Q000235:genetics*
D004274:DNA, Recombinant; D005164:Factor IX