[Role of microcirculatory hemodynamics, blood oxygen balance and carbohydrate metabolism in the pathogenesis of the initial (preclinical) stage of heart failure in ischemic heart disease].
A total of 207 patients with chronic coronary heart disease in the preclinical stage of heart failure were examined. In the majority of patients with the lack of marked changes in myocardial contractility at rest, the initial stage of heart failure was chiefly caused by microcirculatory disturbances that led to a change in blood oxygen balance, activation of glycolysis, pentosophosphate cycle and the Krebs cycle of tricarboxylic acids under the conditions of reduced aerobic oxidation of carbohydrates.
D000328:Adult; D000368:Aged; D002241:Carbohydrates / Q000097:blood*; D002908:Chronic Disease; D003228:Conjunctiva / Q000098:blood supply*; D003327:Coronary Disease / Q000150:complications* / Q000503:physiopathology; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008833:Microcirculation / Q000503:physiopathology; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure
D002241:Carbohydrates; D010100:Oxygen
Rol' mikrotsirkuliatornoĭ gemodinamimki, kislorodnogo balansa krovi i uglevodnogo obmena v patogeneze nachal'noĭ (doklinicheskoĭ) stadii serdechnoĭ nedostatochnosti pri ishemicheskoĭ bolezni serdtsa.