The key role of sex dependency on kidney citrate metabolism in the rat.
An evaluation of the potential role of the kidney in the regulation of the blood citrate level under different acid-base statuses and various diets was performed. Twenty-four hours after bilateral nephrectomy there was a highly significant increase in the blood citrate concentrations in female rats, whereas the blood citrate levels either remained unchanged or decreased in bilateral nephrectomized male animals. Our data clearly indicate a key role of sex dependency on kidney citrate metabolism in the rat.
D020155:3-Hydroxybutyric Acid; D000136:Acid-Base Equilibrium; D000818:Animals; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D005260:Female; D006885:Hydroxybutyrates / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013217:Starvation
D002951:Citrates; D006885:Hydroxybutyrates; D019343:Citric Acid; D020155:3-Hydroxybutyric Acid