Cyclophosphamide-associated hepatotoxicity.
Cyclophosphamide, a potent alkylating agent, is effective therapy for some rheumatic diseases. Despite primary hepatic activation of the drug, hepatic toxicity has been reported only in one case. We have reported two episodes of hepatic dysfunction associated with oral cyclophosphamide administration in patients with systemic rheumatic diseases.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D003520:Cyclophosphamide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008297:Male; D009220:Myositis / Q000188:drug therapy
D003520:Cyclophosphamide