Pharmacokinetics: metabolism and renal excretion of quinolones in man.
The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination, though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body.
D000890:Anti-Infective Agents / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007674:Kidney Diseases / Q000652:urine; D007700:Kinetics; D009268:Nalidixic Acid / Q000378:metabolism; D011804:Quinolines / Q000378:metabolism* / Q000652:urine
D000890:Anti-Infective Agents; D011804:Quinolines; D009268:Nalidixic Acid