The effect of vehicle on the oral absorption of cyclosporin.
Twelve healthy volunteers received four separate doses of cyclosporin (5 mg kg-1). On three occasions the neat oil suspension (Sandimmun) was given dispersed in a different liquid vehicle and on one occasion the suspension was taken directly. Measurement of whole blood cyclosporin concentrations by radioimmunoassay showed no significant difference in the pharmacokinetic parameters of absorption between the neat preparation and the three dispersants used (milk, milk + chocolate flavouring and orange juice).
D000328:Adult; D001628:Beverages; D003524:Cyclosporins / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D014677:Pharmaceutical Vehicles
D003524:Cyclosporins; D014677:Pharmaceutical Vehicles