Selective induction of nasal cavity tumors in rats by diallylnitrosamine.
Weekly intragastric administration of 20, 40, and 80 mg/kg body weight diallylnitrosamine to BD IX rats selectively induced nasal and paranasal cavity tumors with incidences of 30%, 85%, and 65% in females and of 0%, 75%, and 80% in males, respectively. All tumors were carcinomas of the olfactory region, and 95% were invasive. Only a few papillomas in the anterior region were found simultaneously with the carcinomas.
D000230:Adenocarcinoma / Q000139:chemically induced; D000284:Administration, Oral; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D005260:Female; D008297:Male; D009296:Nasal Cavity / Q000187:drug effects / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009602:Nitrosamines; C015125:diallylnitrosamine