title: Effect of surfactants on weight gain in mice.
abstract: A study was conducted to determine if four surfactants can induce increased weight gain in the mouse. Basic-H, Triton X-100, Amway All Purpose Adjuvant and X-77 were put in water and fed to various groups of ICR 21 day old female mice for a period of 43 days. All the mice were clinically normal throughout the study period. Pathological examination of a random sample of the mice revealed no gross pathological changes. Similarly, histopathological examination of the lungs, livers and intestines did not reveal any visible lesions. Basic-H and Amway surfactants induced weight gain, though not significantly, better at 0.1% (V/V) concentration while X-77 and Triton X-100 induced weight gain better at 0.4% (V/V) concentration. Overall results show that none of the surfactants tested induced significant weight gain.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors; D014886:Weaning
chemical_list: D013501:Surface-Active Agents