title: Genotypic characterization of type-2 variants of canine adenovirus.
abstract: Two canine adenovirus (CAV) isolates, apparently distinct from type-1 (Utrecht) and type-2 (Toronto A26/61) reference strains in their biochemical and/or immunologic properties, were submitted to DNA-restriction endonuclease analysis. Both isolates, designated IAF-81-2116 and IAF-75-95, appeared as genotypic variants of CAV-2. Isolate IAF-81-2116 was recovered from the intestine of a young pup with diarrheal disease. Seemingly, relatively small changes in the original CAV-2 DNA sequence allowed the virus to replicate at an unusual site in the dog.
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000648:ultrastructure; D000818:Animals; D002460:Cell Line; D004279:DNA, Viral / Q000302:isolation & purification; D004285:Dogs; D005814:Genes, Viral; D014644:Genetic Variation; D005838:Genotype; D006385:Hemagglutination Inhibition Tests; D007668:Kidney; D008854:Microscopy, Electron
chemical_list: D004279:DNA, Viral