title: No effect of cefaclor on theophylline pharmacokinetics.
abstract: The effect of the antibiotic drug cefaclor on steady state pharmacokinetics of theophylline was studied in healthy adults by comparing the pharmacokinetic parameters as found during a 9 days course of theophylline alone and as obtained during comedication with cefaclor. Theophylline plasma concentrations were measured by means of HPLC analysis. On the ninth day of each of the 2 periods of drug administration, a concentration-time curve was evaluated. It showed no influence of cefaclor on volume of distribution and clearance of theophylline and only a slight, but significant (p less than 0.05) influence on the values for Cmax and tmax after cefaclor co-treatment. It is concluded that both drugs can be given concomitantly without any dosage adjustment of theophylline.
mesh_terms: D000328:Adult; D002433:Cefaclor / Q000097:blood / Q000494:pharmacology*; D002506:Cephalexin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D013806:Theophylline / Q000097:blood*
chemical_list: D002433:Cefaclor; D013806:Theophylline; D002506:Cephalexin