title: Greater brain response of left-handers to drugs.
abstract: Among subjects participating in 14 placebo-controlled drug cross-over studies, left-handers showed a greater drug-related change in their electroencephalograms (EEGs) than did right-handers. Response differences between left- and right-handers were not hemisphere-specific. Further, the magnitude of EEG changes correlated with handedness scores. A greater effect of centrally active substances in left-handers may, in part, explain the high incidence of left-handers among those with certain brain-related pathologies and the evolution of right-hander predominance in the general population.
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D007839:Functional Laterality / Q000502:physiology*; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male