title: Influence of ampicillin elimination half-life on in-vitro bactericidal effect.
abstract: Escherichia coli ATCC 12407 was exposed in an in-vitro kinetic model to multiple dose ampicillin regimens differing in simulated drug elimination half-life but with equal dosage intervals and similar dose levels. Bacterial sensitivity was monitored during drug exposure. Greater bactericidal effect was observed with long half-life regimens. The development of rapid low-level resistance was not influenced by the half-life. Results suggest that in-vivo drug activity may be improved by increasing the drug elimination half-life.
mesh_terms: D000667:Ampicillin / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000667:Ampicillin