Accumulation of HDL-like lipoproteins in the plasma low-density fractions of tumor-bearing mice.
Outgrowth of the transplanted GRSL lymphoma in GR mice yielded several-fold increased blood plasma levels of low- and very-low-density lipoproteins, while high-density lipoproteins were strongly reduced. Changes in cholesteryl ester fatty acid profiles indicated an accumulation of HDL-like particles rather than LDL in the low-density fractions. By intravenous injection of [14C]cholesteryl ester-labeled HDL into tumor-bearing mice, conversion of HDL into lipoproteins of low density was demonstrated.
D000818:Animals; D002499:Centrifugation, Density Gradient; D002788:Cholesterol Esters / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D053439:Lipoproteins, HDL2; D008077:Lipoproteins, LDL / Q000097:blood*; D008223:Lymphoma / Q000097:blood*; D051379:Mice
D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D008077:Lipoproteins, LDL; C035392:high density lipoprotein-1