title: Platelet and fibrinogen kinetics in healthy and African swine fever-affected swine: [75Se]selenomethionine-labeling study.
abstract: Platelet and fibrinogen survival times were determined in healthy pigs and in pigs infected with African swine fever (ASF) virus. Cohort labeling with [75Se]selenomethionine was performed. The platelet survival time in healthy pigs was 5.3 +/- 0.7 days, and the fibrinogen survival time was 6.7 +/- 0.8 days. Early deaths and profound thrombocytopenia prevented calculation of accurate platelet and fibrinogen survival times in ASF virus-infected animals. The ASF virus-infected pigs died of extensive hemorrhage and effusions while thrombocytopenic; however, there was normal thrombocytopoiesis during infection, as measured by incorporation of the radionuclide into platelets. There was a slight decrease in plasma fibrinogen concentration when the platelet count decreased. A dysfunctional fibrinogen was present late in the infection.
mesh_terms: D000357:African Swine Fever / Q000097:blood*; D000818:Animals; D001792:Blood Platelets / Q000166:cytology* / Q000502:physiology; D002470:Cell Survival; D005340:Fibrinogen / Q000378:metabolism*; D006410:Hematopoiesis; D010976:Platelet Count / Q000662:veterinary; D012643:Selenium; D012645:Selenomethionine; D013552:Swine / Q000097:blood*
chemical_list: D005340:Fibrinogen; D012645:Selenomethionine; D012643:Selenium