Cardiotoxicity as a result of 5-fluorouracil therapy.
We report the case of a patient bearing a sigmoid colon carcinoma, stage IV, who after 11 months of antiblastic therapy, having completed a dose of 81,000 mg of 5-FU and CCNU, suffered a myocardial infarct. We attribute this complication to 5-FU. Due to the fact that the coronary angiogram did not confirm the arteriosclerotic nature of the lesion, we suggest that it could have been caused by an endoarteritis, resulting from an immuno-allergic or toxic cumulative process.
D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy; D000328:Adult; D005472:Fluorouracil / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced; D012811:Sigmoid Neoplasms / Q000150:complications / Q000188:drug therapy; D013997:Time Factors
D005472:Fluorouracil