Prevalence of chlorpropamide alcohol flush in Jewish Israeli diabetics. The role of serum chlorpropamide concentrations.
Among 53 patients with noninsulin-dependent diabetes (NIDD), chlorpropamide alcohol flushing (CPAF) was more prevalent than among 18 patients with insulin-dependent diabetes (64 vs. 28%, respectively). Among the former, chronic users of chlorpropamide (CP) had a higher prevalence of CPAF than those challenged once with the drug (86 vs. 56%, respectively). Serum CP concentrations were much higher in CP-treated patients, but levels were not different in CPAF-positive compared with CPAF-negative subjects, regardless of the length of their exposure to the drug. Our data confirm the association between CPAF and NIDD in a Jewish Israeli diabetic population and the effect of serum CP levels on the prevalence of this phenomenon.
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D001831:Body Temperature / Q000187:drug effects; D002747:Chlorpropamide / Q000009:adverse effects / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D005145:Face; D005260:Female; D005483:Flushing / Q000209:etiology*; D006801:Humans; D007557:Israel; D007585:Jews; D008297:Male; D008875:Middle Aged
D000431:Ethanol; D002747:Chlorpropamide