Transport of conjugates of toxicants by blood proteins.
Binding of naphthol and its glucoside and glucuronide conjugates by blood proteins was studied in vitro and in vivo. Binding was found to be primarily to the albumin fraction of human blood and the binding constants were moderate to low. Both in vivo (mice) and in vitro (human) experiments suggest that a substantial portion of naphthol and two conjugates are transported in bound form to the site of elimination.
D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008813:Mice, Inbred ICR; D009284:Naphthols / Q000097:blood; D011042:Poisons / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D012995:Solubility
D001798:Blood Proteins; D002352:Carrier Proteins; D009284:Naphthols; D011042:Poisons; D012709:Serum Albumin