Specific bronchoalveolar lavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate.
We evaluated a patient for dyspnea, fever, malaise, and hypoxemia that developed after exposure to diphenylmethane diisocyanate (MDI). Specific inhalation challenge with MDI caused fever, leukocytosis, a restrictive decline in forced vital capacity, and a decrease in Pao2 several hours after challenge. Bronchoalveolar lavage 24 h after challenge showed lymphocytic alveolitis. Specific IgG antibodies to MDI human serum albumin (MDI-HSA) conjugate were demonstrated in serum and bronchial lavage fluid using the enzyme-linked immunoabsorbent (ELISA) technique. These findings suggest participation of both humoral and cellular immunity in the pathogenesis of hypersensitivity pneumonitis from isocyanate exposure.
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D001980:Bronchi / Q000276:immunology; D001999:Bronchoscopy; D003485:Cyanates / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D017953:Isocyanates; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000276:immunology; D001559:Benzhydryl Compounds
D003485:Cyanates; D007074:Immunoglobulin G; D017953:Isocyanates; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds