title: Effect of diverting colostomy on collagen metabolism in the colonic wall. Studies in the rat.
abstract: The effect of total bowel rest by colostomy on collagen metabolism was studied. Fecal diversion led to a marked decrease of collagen and protein synthesis in the excluded colon. These changes were accompanied by a decrease in the amount of collagen and noncollagenous components. In the colonic part proximal to the colostomy site, a less marked decrease in collagen content was observed. It was concluded that stimulation of intraluminal bulk might be important as a regulating factor for collagen turnover. It remains to be determined if the observed changes in collagen metabolism affect colonic healing.
mesh_terms: D000818:Animals; D001835:Body Weight; D002432:Cecum / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D003106:Colon / Q000378:metabolism*; D003125:Colostomy; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D012007:Rectum / Q000378:metabolism
chemical_list: D003094:Collagen