Construction of human linkage maps: likelihood calculations for multilocus linkage analysis.
Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.
D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D003433:Crosses, Genetic; D005163:Factor Analysis, Statistical; D005260:Female; D008040:Genetic Linkage; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D008297:Male; D008433:Mathematics; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D011995:Recombination, Genetic