title: Tetracycline instillation for recurrent cystic thyroid nodules.
abstract: Ten patients, 5 with recurrent pure cystic and 5 with recurrent mixed cystic-solid thyroid nodules, were studied. When repeated needle aspirations failed to decrease reaccumulation of fluid, tetracycline was injected directly into the cysts. As a result, all the pure cysts resolved completely, and four of the five mixed cystic-solid nodules diminished in size and fluid did not reaccumulate. Follow-up ranged from 12 to 20 months (mean 15 months). The procedure was generally well tolerated. It is concluded that instillation of tetracycline into both recurrent pure cystic and mixed cystic-solid thyroid lesions is a simple, safe and effective treatment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003560:Cysts / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013396:Suction; D013752:Tetracycline / Q000008:administration & dosage*; D013959:Thyroid Diseases / Q000188:drug therapy*
chemical_list: D013752:Tetracycline