Abnormal release of storage pool adenine nucleotides from platelets of dogs affected with basset hound hereditary thrombopathy.
Platelets from dogs affected with Basset Hound Hereditary Thrombopathy (BHT), have a thrombasthenia-like aggregation defect but release storage pool ATP in quantities not significantly different from normal controls or BHT heterozygotes when stimulated with 1 X 10(-5)M ADP and 0.22 U/ml thrombin. However, the release occurs so rapidly in the BHT platelets stimulated with ADP that it is complete in approximately one-sixth of the time required for release from normal control and heterozygote platelets. Sequential electron micrographs reveal early release of BHT dense body constituents 30 seconds after stimulation with 1 X 10(-5)M ADP while resting BHT morphology is indistinguishable from normal control animals.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000097:blood / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000097:blood / Q000378:metabolism; D000818:Animals; D001791:Blood Platelet Disorders / Q000097:blood / Q000662:veterinary*; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D008163:Luminescent Measurements; D008854:Microscopy, Electron; D010974:Platelet Aggregation
D000227:Adenine Nucleotides; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate