title: Sequelae of left ventricular electrical endocardial ablation.
abstract: The endomyocardial residual effects of left ventricular endocardial electrical ablation utilizing unipolar and bipolar electrode catheters were studied in 15 dogs. Histopathologic techniques specific for contraction band necrosis revealed that the mean maximal depth and breadth of necrosis was 0.63 +/- 0.44 and 1.23 +/- 0.82 cm, respectively. The dimensions of necrosis were significantly increased when utilizing larger energy discharges, especially through unipolar electrodes. Four dogs died during the procedure, three from ventricular fibrillation and one from asystole, and two died suddenly within the succeeding 24 hours. Endocardial thrombi were noted at necropsy in two dogs. In conclusion, transcatheter endocardial electrical ablation may destroy a sufficient mass of myocardium to interrupt arrhythmogenic conduction tissue, especially when larger currents are delivered through unipolar electrodes. However, serious ventricular arrhythmias and endocardial thrombi should be anticipated.
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000295:instrumentation*; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects / Q000379:methods; D004285:Dogs; D004566:Electrodes / Q000009:adverse effects / Q000627:therapeutic use; D004699:Endocardium / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D013159:Splenic Infarction / Q000209:etiology; D013927:Thrombosis / Q000209:etiology