title: [Verification of a monogenic hypothesis on pedigrees with an arbitrary structure selected for proband. I. Alternative trait].
abstract: On the example of human familial hypercholesterinemia, a method for verification of hypothesis on monogenic diallele control of alternative characters is demonstrated. An algorithm of estimation of genotype frequencies and penetrances by pedigrees selected for collective probands, using the maximum likelihood method, is described.
mesh_terms: D000483:Alleles; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000235:genetics*; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability
vernacular_title: Proverka monogennoĭ gipotezy na rodoslovnykh proizvol'noĭ struktury,vybrannykh po probandu. Soobshchenie I. Al'ternativnyĭ priznak.