Collagen-based wound dressing: effects of hyaluronic acid and fibronectin on wound healing.
Our previous studies have shown that a collagen-based wound dressing induces the spatial deposition of wound tissue. This study was conducted to determine the effects of hyaluronic acid and fibronectin on wound healing. These macromolecules play an important role in wound healing, embryonic development and cellular migration in vitro. The effects of the addition of varying levels of fibronectin and hyaluronate to a collagen sponge were studied. Low levels of both hyaluronate and fibronectin modified the structure of the implant, and resulted in increased chemoattraction, replication and collagen deposition in an in vivo wound healing model.
D000818:Animals; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use*; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D005353:Fibronectins / Q000627:therapeutic use*; D006168:Guinea Pigs; D006801:Humans; D006820:Hyaluronic Acid / Q000302:isolation & purification / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D009779:Occlusive Dressings; D011247:Pregnancy; D012867:Skin; D012871:Skin Diseases / Q000188:drug therapy; D014470:Umbilical Cord; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy
D005353:Fibronectins; D006820:Hyaluronic Acid; D003094:Collagen