Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.
Gnotobiotic mice died 2 days after inoculation of a cytotoxigenic Clostridium difficile strain. Protection occurred when mice were previously inoculated with a strain of Escherichia coli or Bifidobacterium bifidum. Intestinal cytotoxin production was highly reduced in the surviving mice, whereas the C. difficile population level did not decrease to a great extent.
D000328:Adult; D000818:Animals; D000898:Antibiosis; D001419:Bacteria / Q000254:growth & development* / Q000302:isolation & purification; D003013:Clostridium / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D003015:Clostridium Infections / Q000401:mortality*; D003603:Cytotoxins / Q000096:biosynthesis*; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D006801:Humans; D007231:Infant, Newborn; D051379:Mice; D013045:Species Specificity
D003603:Cytotoxins