Systemic malacoplakia in a breeding pig.
An adult breeding pig had multiple disseminated lesions in several organs of the thoracic and abdominal cavities. Histopathologically, the lesions consisted of accumulated histiocytic cells with a few giant cells and a mild infiltration of lymphocytes and plasma cells associated with concentric laminated spherical Michaelis-Gutmann bodies which stained strongly with haematoxylin and varied in diameter. The histological features of the lesions were similar to those of malacoplakia reported in man. The present case seems to be unique because the characteristic lesions were found in many organs including kidneys, liver, spleen, lungs, gall bladder, small intestine and several lymph nodes. The possibility of the haematogenous spread of malacoplakia was suggested by the frequent formation of the lesions in perivascular areas. The present case should be described as "systemic malacoplakia in a breeding pig".
D000818:Animals; D003593:Cytoplasm / Q000648:ultrastructure; D006644:Histiocytes; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes; D008264:Macrophages / Q000648:ultrastructure; D008287:Malacoplakia / Q000473:pathology / Q000662:veterinary*; D010950:Plasma Cells; D012077:Renal Artery / Q000473:pathology; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*