title: Penbutolol Pharmacokinetics: the influence of concomitant administration of cimetidine.
abstract: A possible interaction of penbutolol and cimetidine was investigated in healthy volunteers treated orally for 7 days. The plasma levels of unmetabolized penbutolol showed a slight but non-significant increase. The biphasic elimination kinetics of penbutolol (half-lives 0.8 and 17 h) was not affected by coadministration of cimetidine. Plasma levels of penbutolol were not significantly altered by chronic treatment with cimetidine, whereas the levels of 4-hydroxypenbutolol and 4-hydroxypenbutolol glucuronide were significantly reduced.
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004347:Drug Interactions; D005965:Glucuronates / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D010394:Penbutolol / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D005082:Physical Exertion; D011412:Propanolamines / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005965:Glucuronates; D011412:Propanolamines; D010394:Penbutolol; D002927:Cimetidine; C034270:4-hydroxypenbutolol