title: [Direct and immediate results of the radiation and combined treatment of laryngeal cancer with local use of metronidazole].
abstract: The paper is concerned with the results of radiation and combined therapy of 122 patients with Stage III-IV laryngeal cancer, divided into 2 groups: 74 controls and 48 patients of the study group. The patients of the study group received radiotherapy in combination with local administration of 5% solution of metronidazole in dimethyl sulfoxide. According to biopsy findings, the average concentration of metronidazole in tumor was 569.5 +/- 196 micrograms/g. Therapeutic results were evaluated by the degree of expression of tumor radiation injury and by direct and short-term results. A statistically significant increase in the frequency of Stage IV tumor radiation injury from 31.1 +/- 5.4% in the control group to 58.3 +/- 7.2% in the study group (P less than 0.05) was revealed. The direct and short-term therapeutic results indicate an increase in tumor radiation injury in the patients of the study group.
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003131:Combined Modality Therapy; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008207:Lymphatic Metastasis; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012996:Solutions; D013997:Time Factors
chemical_list: D012996:Solutions; D008795:Metronidazole; D004121:Dimethyl Sulfoxide
vernacular_title: [Neposredstvennye i blizhaĭshie rezul'taty luchevogo i kombinirovannogo lecheniia raka gortani pri lokal'nom primenenii metronidazola.