title: Effects of piretanide on potassium balance in hypertension.
abstract: Ten hypertensive patients completed a trial lasting 12 weeks to measure the effect of long-term treatment with piretanide, a new, powerful 'loop' diuretic, on total body potassium (TBK). After 2 weeks of placebo treatment, they received 6 mg piretanide twice daily. This dose was increased to 6 mg 3 times a day if blood pressure was not satisfactorily lowered after 4 weeks. Blood pressure and plasma potassium levels were measured weekly. The TBK was measured fortnightly. In this study potassium balance was not significantly affected by the administration of piretanide.
mesh_terms: D000328:Adult; D000368:Aged; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004232:Diuretics; D013449:Sulfonamides; C015451:piretanide; D011188:Potassium