Selective effects of gonadal steroids on the response of peripheral serotonin receptors.
The maximal contraction provoked by serotonin (5-HT) in isolated stomach strips of adult rats, a functional index for peripheral 5-HT receptors, was sexually differentiated, androgen-sensitive, and estrogen refractory. This is at variance with the reported sensitivity of central 5-HT receptors to estrogen.
D000375:Aging; D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005748:Gastric Fundus / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000494:pharmacology; D012737:Sex Factors; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D011985:Receptors, Serotonin; D012701:Serotonin; D013739:Testosterone; D004958:Estradiol; C004648:testosterone enanthate