title: Upper airway lesions in children after accidental ingestion of caustic substances.
abstract: Of 33 children admitted within 24 hours after accidental ingestion of a caustic substance, 14 (42.5%) had evidence of upper airway lesions on direct laryngoscopy. Three patients, 10 to 12 months old, needed endotracheal intubation for acute respiratory obstruction; four patients younger than 2 years had severe dyspnea without obstruction; seven patients had mild or no respiratory symptoms. All were discharged without respiratory sequelae, although esophageal stenosis developed in six patients. Nine of 13 patients younger than 2 years, compared to five of 20 patients older than 2 years, had upper airway lesions (P less than 0.01). The frequency of respiratory tract lesions was higher in patients with severe esophagitis. Eleven of 17 patients with severe esophagitis, compared to three of 16 with mild inflammation, had respiratory tract lesions (P less than 0.025). No specific caustic substance predisposed to upper airway lesions.
mesh_terms: D000667:Ampicillin / Q000627:therapeutic use; D002057:Burns, Chemical / Q000209:etiology*; D002424:Caustics / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D004825:Epiglottis / Q000293:injuries; D004945:Esophagoscopy; D005336:Fiber Optic Technology; D005753:Gastric Mucosa / Q000293:injuries; D005931:Glottis / Q000293:injuries; D006801:Humans; D007223:Infant; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D007830:Larynx / Q000293:injuries*; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D002424:Caustics; D000667:Ampicillin; D011241:Prednisone