Calmodulin levels in hypertensive rats.
Intracellular calmodulin levels were measured by direct radioimmunoassay in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). Decreased calmodulin levels were demonstrated in the brain, heart, aorta and kidney of spontaneously hypertensive rats compared with those in Wistar-Kyoto rats. Calmodulin levels in the brain were also decreased in deoxycorticosterone acetate (DOCA)-salt rats, but not changed significantly in the heart, aorta and kidney compared with those in Wistar-Kyoto rats. These findings suggest that intracellular calcium-dependent regulatory systems are genetically disrupted in spontaneously hypertensive rats, but this is probably not an important factor in the development of hypertension.
D000818:Animals; D001011:Aorta / Q000032:analysis; D001923:Brain Chemistry; D002147:Calmodulin / Q000378:metabolism*; D003900:Desoxycorticosterone; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D007668:Kidney / Q000032:analysis; D008297:Male; D009206:Myocardium / Q000032:analysis; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D002147:Calmodulin; D003900:Desoxycorticosterone