title: Androgen and estrogen receptors in perinatal ferret brain.
abstract: Using DNA-cellulose affinity chromatography and either 3H-labeled dihydrotestosterone, testosterone, or estradiol, we qualitatively and quantitatively analyzed the androgen- and estrogen-binding activities present in four regions of male and female ferret brain at prenatal, early and late neonatal, and adult ages. The cytosolic androgen- and estrogen-binding activities in ferret brain at all ages studied were qualitatively similar in both sexes and in all brain regions and exhibited characteristics which resemble those of androgen and estrogen receptors from other species, including rodents and nonhuman primates. A developmental analysis indicated that high levels of both androgen and estrogen receptors were present in the hypothalamus-preoptic area as early as 5 days before birth. A significant, transient decline in concentrations of estrogen receptors (approximately 5-fold) occurred in anterior hypothalamus-preoptic area and mediobasal hypothalamus at 12 days of age in both males and females; this phenomenon has not been observed in any other species studied to date. The observed ontogeny of androgen receptors correlates with the known ability of testosterone, acting over postnatal days 5 to 20, to cause coital masculinization in ferrets, whereas the observed postnatal dip in estradiol receptor concentrations correlates with the inability of estradiol to cause coital masculinization or defeminization of receptive behavior in this species.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D002335:Carnivora / Q000378:metabolism*; D005260:Female; D005289:Ferrets / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D008297:Male; D010500:Perinatology; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012737:Sex Factors; D014018:Tissue Distribution
chemical_list: D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011987:Receptors, Steroid