Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog.
The influence of phenobarbital and TCDD pretreatment on the formation and biliary excretion of TCDD-metabolites following single doses of 3H-TCDD was investigated. Without pretreatment, 24.5% of the absorbed 3H-TCDD dose was excreted in the bile within 110 h. Phenobarbital did not influence this rate, whereas a single dose of 10 micrograms of unlabeled TCDD/kg b.wt nine days earlier resulted in a doubling of the amount of radioactive material eliminated in the bile (47.4%).
D000818:Animals; D001646:Bile / Q000378:metabolism; D004147:Dioxins / Q000378:metabolism*; D004285:Dogs; D005243:Feces / Q000032:analysis; D007408:Intestinal Absorption; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D000072317:Polychlorinated Dibenzodioxins / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D010634:Phenobarbital