Intramitotic variation in proliferative potential: stochastic events in cellular aging.
A series of mitotic pairs of cells were isolated and the proliferative potential of each cell determined. Although the proliferative potentials of the two cells of a single pair were similar for most pairs examined, in a significant proportion large differences were observed. These results suggest a strong stochastic component in the somatic inheritance of proliferative potential. This observation provides the basis for refinement of a mathematical model for in vitro cellular aging.
D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes