Evidence for an increase in membrane conductance during adenosine triphosphate-induced depolarization in the guinea-pig vas deferens.
The effects of exogenously applied adenosine triphosphate (ATP) on the smooth muscle of guinea-pig vas deferens were studied with the double sucrose-gap method. ATP evoked a membrane depolarization which was associated with a decrease in the size of electrotonic potentials. Conditioning hyperpolarization induced by current application caused an increase in the magnitude of the ATP-induced depolarization; the larger the conditioning hyperpolarization, the greater the ATP-induced depolarization. These results are discussed with respect to the ionic mechanism of the electrical event in response to ATP in this tissue.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008566:Membranes / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects*
D000255:Adenosine Triphosphate