Sera from diabetic pregnant women contain reduced titres of inhibiting factors on killer cell activity.
The presence of Fc-receptor-blocking factors in the sera of normal and insulin-dependent diabetic pregnant women was investigated by means of an antibody-dependent cell-mediated cytotoxicity assay. Sera from normal pregnant women induced a significant depression of antibody dependent cell-mediated cytotoxicity when compared with sera from normal and diabetic non-pregnant women (p less than 0.0001; p less than 0.002, respectively). The effect of sera from diabetic pregnant women, however, was not different from that observed with sera from normal and diabetic non-pregnant women. Thus, we confirm the presence of Fc-receptor-blocking factors in the sera of normal pregnant women. The higher cytotoxicity levels measured in the presence of sera from pregnant women with insulin-dependent diabetes suggests that the titres of such factors are reduced in this condition.
D000293:Adolescent; D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood / Q000276:immunology*; D011961:Receptors, Fc / Q000378:metabolism
D011961:Receptors, Fc