Inactivity of styrene in the mouse sperm morphology test.
Male F1-mice (C3H/He X C57B1/6J) were exposed to styrene by inhalation (150 and 300 ppm; 6 h per day; 5 days) or intraperitoneally (175, 350 and 700 mg/kg per day, 5 days). No statistically significant increase was detected in the frequency of abnormal sperm heads 3 weeks (spermatids exposed) or 5 weeks (late spermatogonia/early spermatocytes exposed) after the beginning of the exposures.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005740:Gases; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*; D020058:Styrene; D013343:Styrenes / Q000633:toxicity*
D005740:Gases; D009153:Mutagens; D013343:Styrenes; D020058:Styrene; D003520:Cyclophosphamide