title: Are there adverse effects of periconceptional spermicide use?
abstract: Recent studies have suggested that spermicide exposure around conception may cause congenital malformations, reduced birth weight, or spontaneous abortion. This large, prospective study examined the risk for multiple malformation, patterns of malformations, low birth weight, preterm delivery, and spontaneous abortion in infants whose mothers used spermicides only before or after their last menstrual period, compared with a control group using other contraceptive methods. The multiple malformation rates in women using spermicides only before or after their last menstrual period were 3.8 and 4.8 per thousand, respectively. For the control groups, the corresponding rates were 5.4 and 6.4 (not significant). No pattern of malformations was found in spermicide-exposed infants. The risk of preterm delivery, the risk for producing a low-birth-weight (less than 2500 gm) infant, and the risk of spontaneous abortion were no higher in women exposed to spermicides than in women using other methods of contraception. This study finds no evidence that spermicide exposure around the time of conception is dangerous to the fetus.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000022:Abortion, Spontaneous / Q000139:chemically induced; D000328:Adult; D001724:Birth Weight; D003271:Contraceptive Agents, Female / Q000009:adverse effects; D003274:Contraceptive Devices, Female / Q000009:adverse effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D008597:Menstrual Cycle; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D012744:Sex Ratio; D013089:Spermatocidal Agents / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D003271:Contraceptive Agents, Female; D013089:Spermatocidal Agents