title: Liquid chromatographic determination of primidone in tablets: collaborative study.
abstract: Six laboratories collaboratively studied a liquid chromatographic (LC) method for the quantitative determination of primidone in tablets. Two lots each of commercially prepared 50 and 250 mg tablets and 2 authentic mixtures, at 50 and 250 mg levels, were sent to each collaborator. Samples were dissolved in the mobile phase, filtered, and injected into the chromatograph. Average recoveries for the 8 samples ranged from 97.5 to 101.2%, and coefficients of variation ranged from 0.53 to 3.01%. The LC method has been adopted interim official first action.
mesh_terms: D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D011324:Primidone / Q000032:analysis*; D013607:Tablets / Q000032:analysis
chemical_list: D013607:Tablets; D011324:Primidone