title: Rare adverse reactions to nonsteroidal antiinflammatory drugs.
abstract: Excluding the most frequent kinds of problems seen with the nonsteroidal antiinflammatory drugs (NSAID)--gastritis, peptic ulceration and renal effects--published reports indicate that these drugs may cause a wide variety of rare adverse reactions. The most serious of these are hypersensitivity reactions: blood dyscrasias (aplastic anemia, thrombocytopenia, agranulocytosis, hemolytic anemia), erythema multiforme and hepatitis. Aseptic meningitis and anaphylactoid reactions may strike patients with underlying immunologic abnormalities; urticaria, bronchospasm and proctocolitis may affect aspirin-sensitive patients. Other unusual reactions include several kinds of bullous dermatitis, febrile reactions, pneumonitis, esophageal ulceration, parotitis, pancreatitis and neurological or psychological effects.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced; D001696:Biomechanical Phenomena; D001847:Bone Diseases / Q000139:chemically induced; D004342:Drug Hypersensitivity; D004892:Erythema Multiforme / Q000139:chemically induced; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced; D008722:Methods; D009336:Necrosis; D010391:Pemphigoid, Bullous / Q000139:chemically induced; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011654:Pulmonary Edema / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced
chemical_list: D000893:Anti-Inflammatory Agents; D001241:Aspirin