[Mechanism of the cerebrovascular effect of piracetam].
Piracetam produces a more pronounced effect on cerebral circulation disturbed by hemorrhagic shock as compared with intact animals. Piracetam has a depressant effect on the nervous regulation of cerebral circulation by suppressing the reflex constriction of the vessels in both arterial systems of the brain. The cerebrovascular effects of piracetam are not mediated through the GABAergic bicuculline-sensitive mechanisms, which is supported by experiments where the drug exhibits its effects under the blockade of GABA receptors.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004562:Electrocardiography; D004569:Electroencephalography; D006439:Hemodynamics / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects
D011760:Pyrrolidinones; D001640:Bicuculline; D010889:Piracetam
K voprosu o mekhanizme tserebrovaskuliarnogo éffekta piratsetamida.