Phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Report of a patient treated with corticosteroid "pulse therapy".
In this report we describe the successful outcome following the use of corticosteroid pulse therapy in a patient with a severe phenytoin hypersensitivity reaction presenting with toxic epidermal necrolysis and severe hepatitis. Steroid pulse therapy may be lifesaving in a severe dermatosis, such as toxic epidermal necrolysis.
D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*
D010672:Phenytoin; D008775:Methylprednisolone