[Effect of adrenalectomy of the recipients of allogeneic lymphocytes on the inactivation of endogenous colony-forming cells in mice].
Intravenous injection of lymph node cells from the parental C57BL/6 mouse line in doses of 2 X 10(6) or 5 X 10(6) into sublethally irradiated (CBA X C57BL/6) F1 hybrids produced more demonstrable suppression of endogenous colony-formation in adrenalectomized recipients as compared with that seen in sham-operated on ones (P less than 0.01). The recipients' adrenalectomy itself was accompanied by an over 2-fold increase in the number of the endogenous colony-forming cells in the spleen as compared with sham-operated on mice. Possible mechanisms, by which the killer action of lymphocytes on the endogenous colony-forming cells is potentiated, are under discussion.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D007694:Killer Cells, Natural / Q000276:immunology / Q000528:radiation effects; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000528:radiation effects; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000276:immunology* / Q000528:radiation effects; D014181:Transplantation Immunology / Q000528:radiation effects
Vliianie adrenaléktomii retsipientov allogennykh limfotsitov na inaktivatsiiu éndogennykh kolonieobrazuiushchikh kletok u mysheĭ.