Induction of proliferation of human circulating monocytes in vitro by lectin-induced factor(s) from lymphocytes.
Human peripheral blood monocytes, which have been considered to be non-dividing cells, were induced to proliferate in vitro by soluble mediator(s) from lectin-activated human lymphocytes. The lectin-induced factor from lymphocytes increased both the number of nuclei of cultured monocytes and [3H]-thymidine incorporation into the monocytes. The molecular weights of the soluble factor(s) that promote growth of monocytes were in the range of 20,000-70,000 daltons with two peaks.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002850:Chromatography, Gel; D006801:Humans; D066298:In Vitro Techniques; D008222:Lymphokines / Q000096:biosynthesis / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000097:blood
D008222:Lymphokines; D010835:Phytohemagglutinins; D013936:Thymidine