The effect of N-acetylcysteine on toxicity of cyclophosphamide and doxorubicin on murine hemopoietic progenitors.
The effect of N-acetylcysteine on hemopoietic stem cells was studied. The drug was given to mice untreated and injected with a single dose of cyclophosphamide or doxorubicin. The results show that the antioxidant drug N-acetylcysteine does not induce any significant decrease in the cytotoxic effect of cyclophosphamide or doxorubicin.
D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D012156:Reticulocytes / Q000187:drug effects
D004317:Doxorubicin; D003520:Cyclophosphamide; D000111:Acetylcysteine