The lymphatic route. 1) Albumin and hyaluronidase modify the normal distribution of interferon in lymph and plasma.
When human recombinant interferon-alpha 2 diluted in saline was injected s.c. into rabbits, the total amount recovered in thoracic lymph was less than 0.4%. Recoveries increased from 2- to 8-fold if interferon was injected in 4% albumin or with hyaluronidase, respectively. Albumin added to interferon acts as an interstitial fluid expander, thus favoring interferon absorption through lymphatics rather than blood capillaries. This strategy may increase the therapeutic index of interferon.
D000818:Animals; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D007370:Interferon Type I / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008196:Lymph / Q000032:analysis*; D008297:Male; D011817:Rabbits; D011994:Recombinant Proteins / Q000097:blood / Q000378:metabolism*; D012709:Serum Albumin / Q000494:pharmacology*
D007370:Interferon Type I; D011994:Recombinant Proteins; D012709:Serum Albumin; D006821:Hyaluronoglucosaminidase