title: Involvement of central catecholamines in mediation of pressor responses of the rat to carotid occlusion.
abstract: Carotid occlusion evoked a pressor response in rats after transection of the spinal cord. Intraventricular pretreatment with 6-hydroxydopamine inhibited the pressor response. The pressor response to occlusion was also diminished by the intraventricular but not by the intravenous injection of guanethidine. Intravenous atropine or mecamylamine, or intraventricular captopril did not affect the pressor response. Thus, it appears that central catecholaminergic mechanisms are involved in the mediation of the pressor response to carotid occlusion.
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000502:physiology*; D002340:Carotid Artery Diseases / Q000503:physiopathology*; D002395:Catecholamines / Q000502:physiology*; D006145:Guanethidine / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000494:pharmacology
chemical_list: D002395:Catecholamines; D014667:Vasopressins; D006145:Guanethidine