Dynamics of otosclerosis-like lesions in LP/J mice.
The LP/J inbred mouse is the first known animal to spontaneously develop otosclerosis-like bone lesions in the middle and inner ear. These abnormal bone foci resemble human otosclerotic lesions, are inherited, and produce a progressive hearing loss. On the basis of histological evaluation alone, it was unclear whether these otosclerosis-like lesions in LP/J mice develop suddenly or gradually as in human otosclerosis. To study the dynamics of lesion formation, four different colored fluorochrome bone labels were given in sequence to postpubertal LP/J mice and CBA/J mice as normal controls. All of the otosclerosis-like lesions incorporated at least one fluorochrome, and half were labeled with two or more markers indicating continuous lesion growth over many weeks. It appears that otosclerosis-like lesions in LP/J mice develop during early adulthood and progress gradually as in human otosclerosis.
D000818:Animals; D004195:Disease Models, Animal; D005456:Fluorescent Dyes; D006314:Hearing Loss, Conductive / Q000209:etiology; D007188:Incus / Q000473:pathology; D008307:Malleus / Q000473:pathology; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D008856:Microscopy, Fluorescence; D010040:Otosclerosis / Q000473:pathology*; D013199:Stapes / Q000473:pathology; D013701:Temporal Bone / Q000473:pathology
D005456:Fluorescent Dyes