Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.
D000818:Animals; D000867:Anterior Chamber / Q000032:analysis; D003315:Cornea / Q000032:analysis; D007065:Idoxuridine / Q000031:analogs & derivatives* / Q000032:analysis / Q000627:therapeutic use; D007457:Iodine Radioisotopes; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D011817:Rabbits
D007457:Iodine Radioisotopes; C030360:5-(2-iodovinyl)-2'-deoxyuridine; D007065:Idoxuridine