Endometrial adenomatous hyperplasia and carcinoma and multiple endocrinopathies in rats exposed to N-nitrosomethylurea.
Female Sprague-Dawley strain rats were given 3 i.v. injections of N-nitrosomethylurea, 4 mg/100 g body weight, at 4 weekly intervals. All rats developed mammary tumors, which were then excised to prolong survival. Seven months after the first injection, 14 of 27 (52%) rats examined has adenomatous hyperplasia of the endometrium, and 6 (22%) had endometrial carcinomas. The remaining 7 animals had varying degrees of hyperplasia, some with squamous metaplasia. Endocrine pathology in these same rats included hyperplasia of the eosinophilic and basophilic cells of the hypophysis (100%), adrenocortical adenomas (81%), polycystic ovaries (70%), thyroid follicular enlargement with colloid accumulation (67%), and parathyroid hyperplasia (7%). Serum TSH levels were elevated in the rats with thyroid abnormalities.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004717:Endometrium / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006965:Hyperplasia; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008679:Metaplasia; D008770:Methylnitrosourea; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000097:blood; D014594:Uterine Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008770:Methylnitrosourea; D013972:Thyrotropin