title: Trans-stimulation and trans-inhibition of uridine efflux from human erythrocytes by permeant nucleosides.
abstract: The ability of nucleoside permeants to accelerate the efflux of uridine from human erythrocytes has been compared. In contrast to uridine, 2-chloroadenosine acted as a trans-inhibitor of uridine efflux from fresh human erythrocytes, and adenosine had little effect. These results are consistent with the lower maximum velocity for influx of 2-chloroadenosine and adenosine as compared with uridine and demonstrate that trans acceleration experiments do not discriminate between transported and non-transported permeants for the human erythrocyte nucleoside carrier.
mesh_terms: D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009705:Nucleosides / Q000494:pharmacology*; D014529:Uridine / Q000097:blood* / Q000494:pharmacology
chemical_list: D009705:Nucleosides; D015762:2-Chloroadenosine; D000241:Adenosine; D014529:Uridine