title: [Mechanism of formation of intramedullary cavities and their role in the regeneration of the spinal cord].
abstract: The spinal cord preparations of 38 dogs and 20 rabbits have been studied with the aim to investigate the influence of the cerebrospinal fluid on the spinal cord nervous tissue. The spinal cord preparations of 8 patients having trauma of the vertebral column with interruption of the spinal cord have also been studied. As demonstrate histological investigations, the cerebral tissue of the pieces, put into the flask with liquor, in the subarachnoidal space of the canine spinal cord, in diastasis between the ends of the cut spinal cord during 6 h up to 7 days, swells, becomes edematous. Cavities occupying about 30% of the area in the slices studied appear in it. At hemisection of the rabbit spinal cord without closure of the defect in the meninx vasculosa with the glue MK-6, the area of the cavity formation varies from 24 up to 35%, comparing the whole area of the preparation, while in rabbits with hemisection and successive gluing of the defect in the meninx vasculosa the area of the nervous tissue destruction makes 13-18%. It has been proved that the scar forming in the traumatized segment of the spinal cord does not present a continuous formation, but contains a large amount of cavities that prevent regeneration of nerve fibers. The experimental data concerning lysing effect of the cerebrospinal fluid on the traumatized nervous tissue are confirmed by the results obtained at investigating the preparations of the spinal cord of the patients died as the cause of the spinal cord trauma.
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D011817:Rabbits; D012038:Regeneration; D013116:Spinal Cord / Q000473:pathology* / Q000502:physiology; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid / Q000473:pathology*
vernacular_title: Mekhanizm obrazovaniia intramedulliarnykh polosteĭ i ikh rol' v protsesse regeneratsii spinnogo mozga.