Multiple myeloma terminating in acute eosinophilic leukemia.
A 71-year-old woman with multiple myeloma was successfully managed for 8 years with melphalan (total dose 2056 mg). She developed a refractory anemia (myelodysplastic state), which terminated in acute eosinophilic leukemia. This form of acute leukemia, induced by chemotherapy, appears to be very rare. The cytogenetic changes, including 5q- and monosomy 7, were similar to those observed in other patients with acute nonlymphocytic leukemia as a secondary malignancy following treatments of other primary tumors.
D000208:Acute Disease; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D004804:Eosinophils; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D008558:Melphalan / Q000009:adverse effects*; D009101:Multiple Myeloma / Q000188:drug therapy*
D008558:Melphalan