Experimental osteoarthritis induced by selective myectomy and tendotomy.
A new model of osteoarthritis has been developed that utilizes an extraarticular surgical technique to alter gait and weight-bearing capabilities in the hind limbs of experimental animals. Guinea pigs, averaging 650 gm in weight, were subjected to unilateral resection of a segment of the gluteal muscles at the sacral origin, to section of the infrapatellar ligament, or to both procedures. Progressive changes consistent with osteoarthritis developed over 10-24 weeks as judged by gross, radiologic, and microscopic findings. In addition, an increase in mean cartilage water content and 35SO4(-2) incorporation into proteoglycans by 10 and 14 weeks, respectively, were consistent with the chemical changes observed in early osteoarthritis. Abnormalities developed not only in the operated hind limb, but in the contralateral, unoperated hind limb at a slightly later time. Thus, this animal model provided the opportunity to evaluate a mild gait abnormality and other biomechanical influences on the evolution of osteoarthritis which is uninfluenced by any intraarticular joint trauma.
D000818:Animals; D002358:Cartilage, Articular / Q000032:analysis / Q000473:pathology; D004195:Disease Models, Animal; D005270:Femur Head / Q000473:pathology; D005684:Gait; D006168:Guinea Pigs; D006614:Hindlimb; D006621:Hip Joint / Q000000981:diagnostic imaging; D007719:Knee Joint / Q000473:pathology; D008023:Ligaments, Articular / Q000601:surgery; D008297:Male; D009132:Muscles / Q000601:surgery*; D010003:Osteoarthritis / Q000209:etiology*; D011509:Proteoglycans / Q000032:analysis; D011859:Radiography; D013462:Sulfur Radioisotopes; D013710:Tendons / Q000601:surgery*; D013977:Tibia / Q000473:pathology; D013997:Time Factors
D011509:Proteoglycans; D013462:Sulfur Radioisotopes