title: Effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol.
abstract: Recent studies have implicated elevated levels of serum estradiol in males as the major predisposing factor for myocardial infarction, with serum cholesterol playing a secondary role. The purpose of the present study was to investigate the effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet and daily exercise on levels of serum estradiol, testosterone, and lipids in males. Twenty-one males participating in the Pritikin Longevity Center 26-day residential program volunteered for the study. During the program, serum estradiol levels were significantly reduced from 47.2 +/- 4.6 to 23.8 +/- 2.5 pg/ml (mean +/- SE) whereas serum testosterone levels were unchanged (5.1 +/- 0.3 versus 5.1 +/- 0.2 ng/ml). Total serum cholesterol levels were reduced from 229 +/- 9 to 181 +/- 7 mg/dl whereas triglyceride levels were reduced from 301 +/- 66 to 151 +/- 13 mg/dl. High-density lipoprotein-cholesterol levels fell from 41 +/- 3 to 35 +/- 1 mg/dl whereas the ratio of total cholesterol to high-density lipoprotein-cholesterol was unchanged (5.5 +/- 0.4 versus 5.1 +/- 0.3).
mesh_terms: D001786:Blood Glucose; D001835:Body Weight; D002791:Cholesterol, Dietary / Q000009:adverse effects / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood*; D004040:Dietary Carbohydrates / Q000378:metabolism* / Q000627:therapeutic use; D004041:Dietary Fats / Q000009:adverse effects / Q000378:metabolism*; D004958:Estradiol / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000517:prevention & control; D005082:Physical Exertion; D012306:Risk; D013739:Testosterone / Q000097:blood*
chemical_list: D001786:Blood Glucose; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D013739:Testosterone; D004958:Estradiol