Changes in the levels of polyunsaturated fatty acids in the lung and lecithin cholesterol acyl transferase activity in plasma of monkeys exposed to ambient levels of ozone.
A group of 8 sub-adult bonnet monkeys (Macaca radiata) was exposed to 0.15 ppm ozone (O3) and another group of 8 to 0.3 ppm O3, 8 h/day, for 90 days. Four monkeys in the control group breathed filtered air during this period. Polyunsaturated fatty acids (PUFA) comprised about 22% of total fatty acids in the lungs of controls. The PUFA level decreased to about 90% and 6% in monkeys exposed to 0.15 ppm and 0.3 ppm O3, respectively. Lecithin cholesterol acyl transferase (LCAT) activity in the plasma of monkeys exposed to 0.15 ppm O3 was similar to that in the controls. However, the LCAT activity of plasma was significantly increased by the exposure of monkeys to 0.3 ppm O3.
D000388:Air; D000818:Animals; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008255:Macaca radiata; D010126:Ozone / Q000633:toxicity*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D013997:Time Factors
D002788:Cholesterol Esters; D005231:Fatty Acids, Unsaturated; D010126:Ozone; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase