Quinine tolerance during self-stimulation in cats.
Thirsty cats, offered a choice between distilled water and quinine solution, preferred the latter to distilled water and accepted quinine concentrations greater than those they accepted in control sessions when drinking quinine solution was rewarded by hypothalamic stimulation, whereas drinking distilled water was not. When the same stimulation rewarded drinking distilled water only, the cats switched to distilled water and refused quinine solutions at concentrations even less than those previously accepted in control sessions. It was concluded that drinking quinine solution was an instrumental response which secured the desirable hypothalamic stimulation.
D000818:Animals; D002415:Cats; D003216:Conditioning, Operant / Q000502:physiology*; D004326:Drinking; D004361:Drug Tolerance; D007031:Hypothalamus / Q000502:physiology*; D011803:Quinine / Q000502:physiology*; D012054:Reinforcement, Psychology
D011803:Quinine