title: Effect of starch ingestion on plasma glutamate concentrations in humans ingesting monosodium L-glutamate in soup.
abstract: Plasma glutamate concentrations in human subjects are markedly lower when monosodium L-glutamate is ingested in a water solution containing partially hydrolyzed starch than when ingested in water alone. This study was carried out to investigate whether starch ingested as crackers had a similar effect. Eight normal adult subjects (four male, four female) ingested three servings of a beef consommé providing 50 mg/kg body weight monosodium L-glutamate. One serving was consommé alone, the other two were accompanied by sufficient crackers to provide 0.25 or 0.5 g starch per kilogram body weight, respectively. Ingestion of consommé containing glutamate significantly increased the mean plasma glutamate concentration above baseline to a mean peak value 30 min later. The peak after consumption of 0.5 g starch per kilogram body weight, but not 0.25 g/kg body weight, was significantly lower than when consommé alone was ingested. These data indicate that simultaneous ingestion of metabolizable carbohydrate with glutamate has a marked effect on the plasma glutamate response and indicate that the threshold value for carbohydrate is greater than 0.25 g/kg body weight.
mesh_terms: D000328:Adult; D000409:Alanine / Q000097:blood; D000597:Amino Acids, Branched-Chain / Q000097:blood; D001224:Aspartic Acid / Q000097:blood; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005260:Female; D005971:Glutamates / Q000097:blood* / Q000378:metabolism*; D005973:Glutamine / Q000097:blood; D006801:Humans; D008297:Male; D012970:Sodium Glutamate / Q000378:metabolism*; D013213:Starch / Q000494:pharmacology*
chemical_list: D000597:Amino Acids, Branched-Chain; D004040:Dietary Carbohydrates; D005971:Glutamates; D005973:Glutamine; D001224:Aspartic Acid; D013213:Starch; D000409:Alanine; D012970:Sodium Glutamate