title: The biological response to titanium and titanium-aluminium-vanadium alloy particles. II. Long-term animal studies.
abstract: The long-term tissue reactions to particulate titanium and titanium-aluminium-vanadium alloy were investigated by the intra-articular injection of material into the knee joints of mice. The tissue response was studied over a period of 2 to 52 weeks. In general, both materials were well tolerated, there was no evidence of necrosis and only a slight thickening of the synovium occurred around particles. Multinucleated giant cells were only rarely seen and no palpable tumours formed in any animal at any site.
mesh_terms: D000497:Alloys / Q000494:pharmacology*; D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000187:drug effects*; D005260:Female; D007267:Injections; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D014025:Titanium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium