Oncogene expression in rat hepatomas and during hepatocarcinogenesis.
In this study we examined oncogene expression in several Morris hepatomas. We found elevated transcripts for Ha-ras, Ki-ras, and the myc oncogenes, while the src oncogene was not increased. Northern analysis revealed transcript sizes of 1.4 kb for Ha-ras and 2.5 kb for myc. Analysis of primary tumors induced by the carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'-MDAB) showed increasing oncogene transcript production with increasing length of diet. The results show enhanced ras and myc expression in rat hepatocellular carcinomas and during hepatocarcinogenesis.
D000818:Animals; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D009857:Oncogenes; D012334:RNA, Neoplasm / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344
D012334:RNA, Neoplasm; D008749:Methyldimethylaminoazobenzene