The effect of nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors.
The effect of intracellular nucleotides on the rate of spontaneous quantum bumps in Limulus ventral photoreceptors has been examined. Internal dialysis of photoreceptors with solutions lacking nucleotide leads to an elevation of the quantum bump rate that can be reversed by introduction of nucleotide. Similarly, elevation occurs after treating intact cells with the metabolic inhibitor 2-deoxyglucose. This effect can be reversed by intracellular injection of ATP. The rate of spontaneous quantum bumps in unpoisoned cells can be reduced to below normal levels by injection of ATP. These results support the hypothesis that high-energy nucleotides suppress the rate of spontaneous quantum bumps.
D000469:Alkaline Phosphatase / Q000494:pharmacology; D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D003956:Dialysis; D006737:Horseshoe Crabs; D007267:Injections; D009711:Nucleotides / Q000494:pharmacology*; D010786:Photoreceptor Cells / Q000187:drug effects*; D047428:Protein Kinase Inhibitors
D009711:Nucleotides; D047428:Protein Kinase Inhibitors; D003847:Deoxyglucose; D000469:Alkaline Phosphatase