title: The biosynthesis of 3 beta-hydroxy-5,7-androstadien-17-one by the horse fetal gonad.
abstract: Horse fetal gonadal tissue was incubated with 3 beta-hydroxy-5,7-pregnadien-20-one and 5,7-cholestadien-3 beta-ol and it was shown that both substrates were converted to 3 beta-hydroxy-5,7-androstadien-17-one. These findings support the proposal that in this tissue there is a 5,7-diene pathway producing 3 beta-hydroxy-5,7-androstadien-17-one, the putative precursor of equilin in the placenta.
mesh_terms: D000730:Androstadienes / Q000096:biosynthesis*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003684:Dehydrocholesterols / Q000378:metabolism; D005260:Female; D006066:Gonads / Q000196:embryology* / Q000378:metabolism; D006736:Horses; D011245:Pregnadienes / Q000378:metabolism; D011247:Pregnancy
chemical_list: D000730:Androstadienes; D003684:Dehydrocholesterols; D011245:Pregnadienes; C039560:3-hydroxyandrosta-5,7-dien-17-one; C037376:3-hydroxy-5,7-pregnadien-20-one; C016705:7-dehydrocholesterol