Kinetics of 3H-serotonin uptake by platelets in infantile autism and developmental language disorder (including five pairs of twins).
The kinetics of 5-HT uptake by platelets was studied in cases of infantile autism and developmental language disorder (DLD) and normal subjects. Two patients of the autism group were twins, and the seven patients of the DLD group were members of four pairs of twins. The Vmax values (means +/- SD) for autism and DLD were 6.46 +/- .90 pmol 5-HT/10(7) cells/min and 4.85 +/- 1.50 pmol 5-HT/10(7) cells/min, respectively. These values were both significantly higher than that of 2.25 +/- .97 pmole 5-HT/10(7) cells/min for normal children. The Km values of the three groups were not significantly different. Data on the five pairs of twins examined suggested that the elevated Vmax of 5-HT uptake by platelets was determined genetically.
D001321:Autistic Disorder / Q000097:blood* / Q000235:genetics; D001792:Blood Platelets / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004200:Diseases in Twins; D006801:Humans; D007700:Kinetics; D007805:Language Development Disorders / Q000097:blood* / Q000235:genetics; D008297:Male; D012701:Serotonin / Q000378:metabolism*; D014316:Tritium; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D014316:Tritium; D012701:Serotonin