Effects of castration and testosterone treatment on the hexobarbital sensitivity in male rats.
Castration increases the central nervous system (CNS) sensitivity to hexobarbital as measured by an EEG-threshold method. Testosterone treatment in doses from 1 to 5 mg/kg/day decreases CNS-sensitivity and restores threshold values in castrated rats to a level found in normal young adult male rats.
D000818:Animals; D001835:Body Weight; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006591:Hexobarbital / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D006591:Hexobarbital