A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young children with asthma.
Sixty-one chronic asthmatic children received either a new slow-release sprinkle format of theophylline, twice daily, or theophylline liquid, 4-times per day. Over a study period of three months, there was no measurable difference in compliance or symptom control between the two groups. The sprinkle-treated patients, however, had a greater incidence of side-effects and had higher rates of nebulization with beta-agonists. Possible explanations are discussed.
D000042:Absorption; D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D004304:Dosage Forms; D005069:Evaluation Studies as Topic; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011897:Random Allocation; D013806:Theophylline / Q000008:administration & dosage* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D004304:Dosage Forms; D013806:Theophylline