Retinal pigment epithelial correlates of avian retinal degeneration: electron microscopic analysis.
The delayed amelanotic (DAM) strain of domestic chicken is characterized by an early, developmental onset of choroidal inflammation and destruction of both feather and choroidal melanocytes. Secondarily, retinal pigment epithelial (RPE) cells in the peripapillary region develop abnormalities, and a series of progressive histopathological changes ensues which includes reduction and ultimate loss of RPE-melanin granules and RPE-cell atrophy. The earliest sign of RPE-cell abnormality is a dramatic alteration in the distribution of intracellular melanin granules. Apical processes also show a lessening of contact with photoreceptor outer segments, leading in more advanced stages to their retraction and development of retinal detachments. Other progressive alterations in RPE cells include disorganization and loss of basal infoldings; size reductions and density increases in both mitochondria and myeloid bodies from early to advanced stages; appearance of large macrophages in the subretinal space; Loss of intercellular junctional complexes; and progressive reduction in the density of melanin granules. These abnormalities appear to spread in a cell-by-cell, radial pattern, until widespread areas of the retina become severely pathologic and atrophic. The DAM chorioretinal disorder appears to show many of the histopathologic features which characterize experimentally induced uveitis and other ocular diseases which may result from hypersensitivity to, or autoimmune reaction against, pigments of the uveal tract.
D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D002645:Chickens; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D008543:Melanins; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure*; D012162:Retinal Degeneration / Q000235:genetics / Q000473:pathology*; D014617:Vacuoles
D008543:Melanins