Effect of suprofen on corneal wound healing.
We studied the effect of suprofen, a new ophthalmic nonsteroidal anti-inflammatory agent, on corneal wound healing. Nine-millimeter, central, perforating corneal wounds were made in albino rabbits and sutured with 10-0 nylon. The animals were randomly treated with balanced salt solution, suprofen vehicle, 1% suprofen, or 0.1% dexamethasone sodium phosphate administered topically for six days. On the seventh postoperative day, the sutures were removed and, in situ, the intraocular pressure was increased in a controlled manner until the wound burst. Dexamethasone applied four times a day significantly inhibited corneal wound healing, whereas suprofen given as often as hourly did not. Pretreatment with hourly administered suprofen for two days prior to surgery, in addition to the same postoperative hourly therapy, also did not significantly decrease stromal wound strength.
D000287:Administration, Topical; D000818:Animals; D003315:Cornea / Q000502:physiology* / Q000601:surgery; D003907:Dexamethasone / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D011817:Rabbits; D013496:Suprofen / Q000008:administration & dosage / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D010666:Phenylpropionates; D003907:Dexamethasone; D013496:Suprofen