Toxicity of amphotericins on chronic administration to mongrel dogs.
Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003711:Demyelinating Diseases / Q000139:chemically induced; D004285:Dogs; D007668:Kidney / Q000187:drug effects
C017501:methylamphotericin B; D000666:Amphotericin B