Recurrent prolactinoma and meningioma following irradiation and bromocriptine treatment.
This case report describes a 45-year-old man with a massive extrasellar prolactinoma, treated initially with surgery and radiotherapy, who experienced a dramatic reduction of the bulk of his tumor but persistence and subsequent progression of an extrasellar portion while receiving long-term bromocriptine therapy, despite stable, suppressed prolactin levels. Although the residual tumor was thought to be adenomatous tissue unresponsive to bromocriptine, a meningioma was ultimately diagnosed. Because the meningioma may have been radiation-induced, clinicians are reminded to consider a second neoplasm in cases of apparent bromocriptine treatment failures, especially when prolactin levels are stable.
D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008579:Meningioma / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D011388:Prolactin / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D001971:Bromocriptine; D011388:Prolactin