The influence of acetylsalicylic acid on the transepithelial potential difference of gastric mucosa in children.
The gastric transepithelial potential difference seems to be a sensitive parameter of the integrity of gastric mucosa. The administration of acetylsalicylic acid in adults causes a rapid and significant decrease in gastric potential difference, whereas in children this characteristic reaction fails to occur.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001241:Aspirin / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004573:Electrolytes / Q000378:metabolism; D004848:Epithelium / Q000502:physiology; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects
D004573:Electrolytes; D001241:Aspirin