Effect of LTD4 on conjunctival vasopermeability and blood-aqueous barrier integrity.
The effect of leukotriene D4 (LTD4) on the microvascular permeability of selected ocular tissues of the guinea pig was evaluated quantitatively by utilizing 125I-albumin and 51Cr-erythrocytes. Topically applied LTD4 (1 ng-10 micrograms) produced a dose-related increase in conjunctival microvascular permeability. However, topical administration of such doses of LTD4 did not promote albumin leakage into the aqueous humor or iris-ciliary body. Intravitreal injection of graded doses of LTD4 also failed to increase the albumin content of the aqueous humor and iris-ciliary body. Thus, although LTD4 increased conjunctival microvascular permeability, it does not appear to disrupt the blood-aqueous barrier of the guinea pig eye.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000502:physiology*; D002199:Capillary Permeability / Q000187:drug effects; D002924:Ciliary Body / Q000378:metabolism; D003228:Conjunctiva / Q000098:blood supply*; D003315:Cornea / Q000378:metabolism; D065306:Corneal Injuries; D004305:Dose-Response Relationship, Drug; D005143:Eyelids / Q000378:metabolism; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D007498:Iris / Q000378:metabolism; D008297:Male; D013189:SRS-A / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism
D013189:SRS-A; D012709:Serum Albumin; D006632:Histamine