Immune complexes in patients with contact dermatitis.
By C1q binding assay, circulating immune complexes (cic) were detected in 19 out of 30 patients with contact dermatitis to nickel or chromium. Their presence was correlated with the duration of the disease, while any patients positive for cic showed any signs of type III immunopathological lesions. Atomic absorption analysis of the polyethlylene glycol precipitates (PEG ppt) from the sera of 16 patients--8 positive and 8 negative for cic--revealed an amount of nickel or chromium significantly higher in the PEG ppt from the sera of patients positive for cic.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D002857:Chromium / Q000097:blood / Q000276:immunology; D003877:Dermatitis, Contact / Q000097:blood / Q000276:immunology*; D006801:Humans; D009532:Nickel / Q000097:blood / Q000276:immunology
D000936:Antigen-Antibody Complex; D002857:Chromium; D009532:Nickel