title: Bioavailability of dioxin in soil from a 2,4,5-T manufacturing site.
abstract: Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a highly toxic contaminant produced in the manufacture of phenoxy herbicides. Despite its high TCDD content, soil from a contaminated area associated with a 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) manufacturing site in Newark, New Jersey, did not induce acute toxicity when administered to guinea pigs (the most sensitive species) by gavage. Analysis of liver samples demonstrated low bioavailability of TCDD from this soil. A comparative analysis of soils showed that Soxhlet extraction was necessary for the determination of TCDD on Newark soil, whereas solvent extraction was sufficient for soil from Times Beach, Missouri. The difference in the bioavailability of TCDD from these soils is correlated with TCDD extractability and may be related to the different compositions of the soils.
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000138:chemical synthesis*; D000818:Animals; D001572:Benzofurans / Q000032:analysis; D001682:Biological Availability; D002617:Chemical Industry; D004147:Dioxins / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009515:New Jersey; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D012987:Soil / Q000032:analysis; D012989:Soil Pollutants / Q000032:analysis
chemical_list: D001572:Benzofurans; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012987:Soil; D012989:Soil Pollutants; C023614:dibenzofuran; D015085:2,4,5-Trichlorophenoxyacetic Acid