Interaction between ophthalmic drugs and intraocular lenses.
We evaluated the in vitro interaction between commonly used ophthalmic drugs and a series of intraocular lenses to determine if the lenses could act as a drug reservoir in the eye. Lenses examined included anterior and posterior chamber lenses as well as iris plane lenses. Assessment of lens uptake was made by immersing the lens for nine days in a radioactive drug solution with a concentration equal to that found in the anterior chamber one hour after drug administration. No evidence of drug uptake was found for any lens immersed in epinephrine, norepinephrine, dexamethasone, or chloramphenicol.
D000042:Absorption; D000327:Adsorption; D002701:Chloramphenicol; D003907:Dexamethasone; D004837:Epinephrine; D007910:Lenses, Intraocular; D009638:Norepinephrine; D009883:Ophthalmic Solutions
D009883:Ophthalmic Solutions; D002701:Chloramphenicol; D003907:Dexamethasone; D009638:Norepinephrine; D004837:Epinephrine