title: The development of reliable compliance tests for antihypertensive drugs.
abstract: Many tests for measuring compliance have been proposed, but in most cases compliance rates have been determined without taking into account the factors influencing the interval during which a drug can be detected by a qualitative test after having been taken by the patient. The drug half-life, often used for determining the time at which the sample is collected, is inadequate for obtaining conclusive test results. A procedure is described for the determination of urine collection intervals during which reliable information on compliance can be obtained, using oxprenolol, hydrochlorothiazide, and pindolol as examples.
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use / Q000652:urine*; D003124:Colorimetry; D004435:Eating; D005260:Female; D006184:Habits; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use / Q000652:urine; D008297:Male; D010096:Oxprenolol / Q000627:therapeutic use / Q000652:urine; D010349:Patient Compliance; D010869:Pindolol / Q000627:therapeutic use / Q000652:urine; D013050:Spectrometry, Fluorescence; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D010096:Oxprenolol; D010869:Pindolol