Sodium pump activity in thymocytes of rats with Goldblatt hypertension.
Sodium transport has been studied in thymocytes of one-kidney, one-clip (1K, 1C) and two-kidney, one-clip (2K, 1C) models of hypertension in the rat. No differences of intracellular sodium or sodium transport could be demonstrated in either model when compared with sham-operated controls. The experiments provide no evidence to support the concept that an inhibitor of sodium transport is associated with the development of hypertension in the one-kidney, one-clip rat. A previously unrecognized effect of incubation time and cell density on thymocyte sodium metabolism is reported.
D000818:Animals; D001693:Biological Transport, Active; D006978:Hypertension, Renovascular / Q000378:metabolism*; D066298:In Vitro Techniques; D007958:Leukocyte Count; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D013997:Time Factors
D012964:Sodium