Synthesis and bioevaluation of a rapidly biodegradable tissue adhesive: 1,2-isopropylidene glyceryl 2-cyanoacrylate.
A rapidly biodegradable tissue adhesive, 1,2-isopropylidene glyceryl 2-cyanoacrylate, was synthesized and characterized by NMR. Bond strength was determined. Three types of corresponding polymers were prepared and evaluated for in vitro and in vivo toxicity. The polymers were generally found to be in the moderately toxic and toxic groups similar to the lower alkyl 2-cyanoacrylates.
D000268:Adhesiveness; D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003487:Cyanoacrylates / Q000138:chemical synthesis* / Q000633:toxicity; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D014014:Tissue Adhesives / Q000138:chemical synthesis*
D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives; C048604:1,2-isopropylidene glyceryl 2-cyanoacrylate