Effect of triiodothyronine on intestinal and kidney isoenzymes of alkaline phosphatase and on vitamin D metabolism in adult female rats.
Adult female Wistar rats receiving normal or vitamin D restricted diet were made thyrotoxic by subcutaneous injection of T3. T3 treatment enhanced intestinal alkaline phosphatase activity and augmented the stimulatory effect of vitamin D on the enzyme in this tissue. In kidney, T3 treatment lead to a decrease in alkaline phosphatase activity in normal, vitamin D restricted and vitamin D repleted rats. The conversion of 25OHD3 to 24,25(OH)2D3 in vivo was enhanced in thyrotoxic rats. These results suggest an interaction between the thyroid and vitamin D endocrine systems.
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D005260:Female; D006980:Hyperthyroidism / Q000201:enzymology; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D007527:Isoenzymes / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology*; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000201:enzymology*
D007527:Isoenzymes; D014284:Triiodothyronine; D014807:Vitamin D; D000469:Alkaline Phosphatase