Hypertrophy of liver peroxisomes in type II and type IV hyperlipoproteinemia.
A morphometric study on liver biopsies from patients with primary hyperlipoproteinemia (IIa n = 4, IIb n = 7, IV n = 7) and in controls (n = 7) was performed by light and electron microscopy. We found hypertrophy of peroxisomes in all subjects with hyperlipoproteinemia. As none of our patients had been given lipid-lowering drugs, this increase in volume seems to be due to hyperlipoproteinemia. Hypertrophy of peroxisomes in hyperlipoproteinemia may constitute a response of the hepatocyte to a disturbed metabolic state. Alterations of peroxisomes in hyperlipoproteinemia may thus occur prior to any lipid-lowering therapy.
D000328:Adult; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000145:classification / Q000473:pathology*; D006953:Hyperlipoproteinemia Type IV / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D008830:Microbodies / Q000473:pathology*; D008875:Middle Aged