[Effect of desglycine-arginine vasopressin on the excitability of the command neurons of the defensive reflex in the edible snail].
Perfusion of the snail (Helix lucorum L.) CNS with DG-AVP (concentration 10(-6) M) in the course of low frequency intracellular stimulation (2-4-minute interval) of the defensive reflex command neurons led to an increase in the excitability. It was expressed both in the reduction of the spike generation latency, in the increased number of spikes in response to fixed stimuli, and in the activation of pacemaker potentials. If DG-AVP was added to the medium during endoneuronal habituation, there was no increase in the excitability. It is supposed that modification of the neuronal excitability may be caused by the DG-AVP effect on the pacemaker mechanism.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects*; D006372:Helix, Snails / Q000187:drug effects*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*
D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-
Vliianie dezglitsinarginin-vazopressina na vozbudimost' komandnykh neĭronov oboronitel'nogo refleksa vinogradnoĭ ulitki.