[Change in the level of steroid hormone receptors in the tumors of patients with breast cancer complicated by liver and bile duct diseases].
Estrogen, progesterone and glucocorticoid receptor levels were assayed in cytosols of primary tumor in 132 patients with breast cancer. Concomitant diseases of the liver and bile ducts were detected in 13 of them. Patients with concomitant hepatic pathology showed a relatively lower percentage of tumors bearing receptors of the above steroid hormones. This was matched by a significant reduction in the level of progesterone receptors. The frequency of identification of receptors of both estrogens and progesterone in tumor in cases of concomitant hepatic pathology was three times less than in those free from it.
D000328:Adult; D000368:Aged; D001649:Bile Duct Diseases / Q000150:complications / Q000378:metabolism*; D001943:Breast Neoplasms / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000378:metabolism*; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000150:complications / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*
D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid
Izmenenie soderzhaniia retseptorov steroidnykh gormonov v opukholiakh bol'nykh rakom molochnoĭ zhelezy s zabolevaniiami pecheni i zhelchnykh puteĭ.