Penicillamine-induced ocular myasthenia gravis.
Two patients with rheumatoid arthritis (two women, 58 and 62 years old) developed reversible penicillamine-induced ocular myasthenia gravis. Both had the HLA-DR1 antigen, unlike most patients with idiopathic myasthenia gravis who show HLA-DR3, suggesting that penicillamine-induced myasthenia gravis and its idiopathic counterpart occur in patients with different genetic backgrounds. In both cases, cessation of drug treatment led to resolution of the symptoms.
D005128:Eye Diseases / Q000139:chemically induced / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000139:chemically induced* / Q000235:genetics; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine