Changes in lymphoma development in female SJL/J mice as a function of the ratio in low polyunsaturated/high polyunsaturated fat diet.
A diet of low polyunsaturated-to-saturated fatty acid (P/S) ratio known to alter fatty acid composition of lymphocyte membranes and retard the progressive changes which result in loss of suppressor capacity in SJL/J female mice, was fed to these mice from conception to study its effect on the development of lymphoma. Between 12 and 14 months, at a time when 100% of mice on a diet of high polyunsaturated-to-saturated fatty acid ratio showed lymphoma, only 70% of the mice fed the low P/S diet had developed lymphoma. Dietary fatty acid levels would appear to have a significant effect on the rate of progression of lymphoma in SJL/J female mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated