Sperm counts and reproductive tract lesions in male Syrian hamsters exposed in utero to diethylstilbestrol.
Pregnant hamsters were administered diethylstilbestrol (DES) orally on day 14 of gestation. Sperm counts from F1 adult males were lower than controls. Significant and consistent lesions were confined to the epididymides of DES exposed males, in which epididymal granulomas were the most common lesion. Epididymal granulomas of the tail have been associated with a bacterial etiology while granulomas of the head may be related to blind ductules or a lack of ductule connection.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae / Q000502:physiology*; D004054:Diethylstilbestrol / Q000633:toxicity*; D005260:Female; D005837:Genitalia, Male / Q000187:drug effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D008647:Mesocricetus / Q000502:physiology*; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D013076:Sperm Count / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology
D004054:Diethylstilbestrol