title: Integration of laboratory and epidemiologic studies to evaluate genotoxic exposure in tool and die workers.
abstract: In summary, the data presented here provides perspective on the analysis of cancer in a relatively small population of tool and die workers. Each part of the effort establishes evidence for or against the presence of a workplace carcinogenic effect. Overall, the weight of evidence leads to the hypothesis that cutting fluids are a likely candidate for observed increases in urinary system cancer and perhaps other sites. Because cutting fluids and a wide variety of metals are used together, the interaction of these entities need be considered in the overall process of carcinogenesis in the workplace.
mesh_terms: D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002869:Chromosome Aberrations; D004052:Diethylnitrosamine / Q000031:analogs & derivatives / Q000032:analysis; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D009602:Nitrosamines / Q000032:analysis; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D012854:Sister Chromatid Exchange
chemical_list: D009153:Mutagens; D009602:Nitrosamines; C014129:N-nitrosodiethanolamine; D004052:Diethylnitrosamine