title: A rabbit model of intracerebral hematoma.
abstract: The epiphenomena that seem to cause deterioration and death after spontaneous interacerebral hematoma (SICH) might best be studied in an animal model. Therefore, the principles for developing such a model and techniques to study these phenomena were evaluated. Animals will tolerate injection of 3%-5% of their brain volume with a high proportion of clots. Fluorescein can be used to study the blood-brain barrier, and gravimetry to study edema. Others have found that injection of a paraffin/oil mixture can be employed for a control model. Refinement of the fluorescein technique, development of a primate model, and directions for future research are suggested.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001929:Brain Edema / Q000209:etiology / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000150:complications / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins; D006406:Hematoma; D006801:Humans; D008297:Male; D011817:Rabbits
chemical_list: D005452:Fluoresceins; D019793:Fluorescein