Effect of precursors on biosynthesis of monensins A and B.
Precursors of monensins (acetate, propionate, butyrate, isobutyrate) affect the total production and the relative proportion of monensins A and B. Addition of propionate into the fermentation medium causes a prevalence of monensin B whereas butyrate and isobutyrate stimulate the production of monensin A and suppress the production of monensin B.
D000085:Acetates / Q000494:pharmacology; D019342:Acetic Acid; D002087:Butyrates / Q000494:pharmacology; D020148:Butyric Acid; D005663:Furans / Q000096:biosynthesis*; D058610:Isobutyrates; D008985:Monensin / Q000096:biosynthesis*; D011422:Propionates / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism
D000085:Acetates; D002087:Butyrates; D005663:Furans; D058610:Isobutyrates; D011422:Propionates; D020148:Butyric Acid; C020380:isobutyric acid; D008985:Monensin; C029658:propionic acid; D019342:Acetic Acid