Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats.
Many processes are involved in the renal excretion of drugs, but very little is known about their quantitative structure-activity relationship. The relationship between urinary excretion and lipophilic character of a series of nitroimidazoles and nitrothiazoles was studied. The unmetabolized forms of the drugs were detected in the urine by means of UV and HPLC procedures. The urinary excretion of unmetabolized forms is parabolically related with the log P, as an expression of lipophilic character of molecules.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007668:Kidney / Q000378:metabolism; D009593:Nitroimidazoles / Q000652:urine*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000652:urine*; D013997:Time Factors
D009593:Nitroimidazoles; D013844:Thiazoles