Syntheses and hypotensive properties of substituted 2-aminotetralins.
The synthesis and activity in the spontaneously hypertensive rat of several 4-(1,2,3,4-tetrahydronaphthyl-2-amino)-1-(4-fluorophenyl)-1-but anones is reported. Maximal antihypertensive activity was associated with 5,6-dimethoxy substitution in the aminotetralin moiety.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis*; D051381:Rats; D011918:Rats, Inbred SHR; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis*
D000959:Antihypertensive Agents; D009281:Naphthalenes; D013764:Tetrahydronaphthalenes