title: Cauda equina compression secondary to metastatic carcinoma of the uterine corpus: preservation of neurologic function and long-term survival following surgical decompression and radiation therapy.
abstract: Spinal cord or cauda equina compression secondary to epidural metastasis rarely develops in patients with endometrial carcinoma and the early signs and symptoms of compression can therefore be inadvertently overlooked. A 78-year-old patient who developed bone metastasis with destruction of the fifth lumbar vertebral body and blockage of the cauda equina at L-4, L-5 as the only sites of metastasis is reported. This occurred 2 years after initial treatment of a stage IB, well-differentiated, grade I, adenosquamous carcinoma of the endometrium. The patient remains alive, with good neurological function and free of metastatic disease, 2 1/2 years following vertebrectomy, radiation therapy, and adjuvant Provera (medroxyprogesterone acetate) therapy. This patient represents the only case of metastatic endometrial cancer with cauda equina compression in the literature in whom long-term disease-free follow-up has been noted.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000556:secondary / Q000628:therapy; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000556:secondary / Q000628:therapy; D002420:Cauda Equina / Q000503:physiopathology*; D005260:Female; D006801:Humans; D009408:Nerve Compression Syndromes / Q000209:etiology*; D013125:Spinal Neoplasms / Q000150:complications* / Q000556:secondary / Q000628:therapy; D014594:Uterine Neoplasms / Q000473:pathology / Q000628:therapy