title: Assessment of renal blood flow in dogs: analysis of 131I-hippuran blood clearance in healthy dogs and in dogs with proteinuria.
abstract: In 30 clinically healthy dogs (weights 7.5 to 57 kg) and in 41 proteinuric dogs the 131I-hippuran blood disappearance curve after single injection was determined (0 to 90 minutes), described by a bi-exponential function and analysed according to a two compartment model. The dependence of the blood clearance (C), representing an effective renal blood flow, on the bodyweight (W) (kg) could be described with both a linear function (C = 61 + 13.2 W ml min-1) and a power function (C = 30.56 W0.79 ml min-1) in the healthy dogs. The results of the regression between blood clearance and bodyweight were reproducible (r = 0.92, n = 10 residual error 12 per cent, P less than 0.01).
mesh_terms: D000818:Animals; D001835:Body Weight; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs / Q000502:physiology*; D005260:Female; D007465:Iodohippuric Acid; D008297:Male; D011507:Proteinuria / Q000503:physiopathology / Q000662:veterinary*; D012044:Regression Analysis; D012079:Renal Circulation
chemical_list: D007465:Iodohippuric Acid