[Information value of research on the enzyme status of the peripheral blood leukocytes in a toxicological experiment].
Cytochemical methods were used to explore the changes in the activity of redox (succinate dehydrogenase, mitochondrial alpha-glycerophosphate dehydrogenase) and hydrolytic (acid, alkaline phosphatase, myeloperoxidase) enzymes of peripheral blood leukocytes of random-bred albino rats during simulation of toxic hepato-, nephropathy and hemic hypoxia of different gravity. The studies of the changes of leukocyte distribution according to the activity of the above enzymes were demonstrated to be informative for the diagnosis of prepathological conditions. The possibility was also shown of differentiating the gravity of the pathological conditions with the aid of an analysis of the enzymes under study by the method of linear discriminant functions.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000175:diagnosis; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis; D004796:Clinical Enzyme Tests; D006651:Histocytochemistry; D000860:Hypoxia / Q000139:chemically induced / Q000175:diagnosis; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008630:Mercury Poisoning / Q000175:diagnosis; D051381:Rats; D012977:Sodium Nitrite / Q000506:poisoning
D012977:Sodium Nitrite
Informativost' issledovaniia fermentnogo statusa leĭkotsitov perifericheskoĭ krovi v toksikologicheskom éksperimente.