title: [Pathology and pathogenesis of multiple sclerosis from the viewpoint of neurologic disease research].
abstract: The pathology of multiple sclerosis (MS) is characterized by the trias: inflammation, primary demyelination and reactive gliosis. However, besides these obligatory alterations a high inter- and intraindividual variability of structural aspects is found in MS lesions. Recent experimental studies in a model disease for MS, in chronic relapsing experimental allergic encephalomyelitis, provide a better understanding of the dynamics of lesions development in MS brains.
mesh_terms: D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology; D006801:Humans; D009103:Multiple Sclerosis / Q000473:pathology*; D009186:Myelin Sheath / Q000648:ultrastructure; D009416:Nerve Regeneration; D009836:Oligodendroglia / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000473:pathology; D012106:Research; D013126:Spinal Nerve Roots / Q000473:pathology
vernacular_title: Pathologie und Pathogenese der Multiplen Sklerose im Blickpunkt der neurologischen Krankheitsforschung.