Predicative calculation of the efficiency of hemodialysis or hemoperfusion for the removal of drugs from the body.
Formula are derived for the calculation of the amounts of drug which, during a defined time interval, are eliminated from the body with and without the help of hemodialysis or hemoperfusion (HD/HP). A programmable pocket calculator like the TI-59 suffices to perform all calculations. The pharmacokinetic system constants of the drug, the effective plasma flow, and the HD/HP plasma extraction rate are entered into the program. Additional information can be obtained if the plasma concentration of the drug at the onset of HD/HP is known. Worked examples are presented.
D000435:Alcoholic Intoxication / Q000628:therapy; D001783:Blood Flow Velocity; D001798:Blood Proteins / Q000378:metabolism; D006464:Hemoperfusion; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood*; D011485:Protein Binding; D006435:Renal Dialysis
D001798:Blood Proteins; D004364:Pharmaceutical Preparations