Botulism intoxication after surgery in the gut.
Botulism intoxication is described in a 45-year-old woman who was hospitalized with symptoms suggesting an intestinal obstruction. At intervention a 20-cm length of necrotic small intestine was excised and prophylactic antibiotics were given. Five days after surgery--during which time the patient was fed only parenterally--dryness of the mouth, difficulty in swallowing, general weakness, and difficulty with speech and in keeping her eyes open were noted. The patient was alert and well oriented. The clinical symptoms and the electrophysiological studies suggested the diagnosis of botulism. A serum sample caused death in mice upon inoculation and two samples of feces were positive for the presence of Clostridium botulinum organisms. Supportive treatment with botulinum antitoxin was given and the patient was discharged in good condition.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000032:analysis; D001906:Botulism / Q000097:blood / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000097:blood / Q000382:microbiology / Q000601:surgery*; D008875:Middle Aged; D009500:Neutralization Tests; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D001905:Botulinum Toxins