The effect of a rat plasma high-density lipoprotein subfraction on the synthesis of bile salts by rat hepatocyte monolayers.
The effect of a rat high-density lipoprotein subfraction (HDL2) on the synthesis of bile salts by rat hepatocyte monolayers prepared from rats fed a diet containing cholestyramine, was investigated. The synthesis of bile salts as measured by radioimmunoassay of conjugated cholic, chenodeoxycholic and beta-muricholic acids was significantly increased when hepatocytes were incubated with a physiological concentration (500 micrograms HDL2 protein X ml-1) of HDL2.
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002478:Cells, Cultured; D005260:Female; D007700:Kinetics; D008075:Lipoproteins, HDL / Q000097:blood* / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D008075:Lipoproteins, HDL