Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?
Seven psychotic patients' plasma haloperidol levels, determined with gas-liquid chromatography, fell a mean of 60% when carbamazepine treatment was instituted. Two patients' levels became undetectable, and their symptoms worsened. Haloperidol level monitoring may be required for patients given both haloperidol and carbamazepine.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002849:Chromatography, Gas; D003864:Depression, Chemical; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood / Q000188:drug therapy / Q000523:psychology*
D002220:Carbamazepine; D006220:Haloperidol