Dopamine receptors: structure-activity relationship of d-tubocurarine analogues.
d-Tubocurarine (dTC) and d-tubocurine acted as antagonists of the dopamine-induced inhibition of adrenergic neurotransmission in the isolated, perfused rabbit ear artery. N-Methyl-dTC and O,O,N-trimethyl-dTC (metocurine) did not exhibit dopaminergic antagonist activity. dTC contains one tertiary (3 degrees) nitrogen and one quaternary (4 degrees) nitrogen and d-tubocurine contains two 3 degrees nitrogens; whereas, both N-methyl-dTC and O,O,N-trimethyl-dTC have two 4 degrees nitrogens. The results suggest that a dTC analogue (e.g., metocurine) which lacks a 3 degrees nitrogen should be considered for use in patients treated with dopamine.
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014403:Tubocurarine / Q000031:analogs & derivatives* / Q000494:pharmacology
D011954:Receptors, Dopamine; D014403:Tubocurarine