title: [Effect of preliminary chronic irradiation and alpha-tocopherol on the frequency of chromosome aberrations in mouse bone marrow cells, induced by exposure to acute gamma-irradiation].
abstract: The incidence of chromosome aberrations in bone marrow cells of femur did not exceed the spontaneous one in CBA mice exposed, during 70 days, to gamma-radiation at dose--rates of 33.7-35.8 nA/kg and cumulative dose of 2.75 Gy. A single acute exposure of intact animals to a dose of 2.98 Gy increased significantly the mutation level. Preirradiation with small doses increased the resistance of hereditary structures to sublethal radiation doses. Exogenous alpha-tocopherol (0.06 mg/20 g mass) protected the genetic apparatus of cells from total-body irradiation and was an additional factor decreasing the mutation level after acute exposure of mice at the background of long-term irradiation with small doses.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D051379:Mice; D008808:Mice, Inbred CBA; D011831:Radiation Genetics; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D003037:Cobalt Radioisotopes; D014810:Vitamin E
vernacular_title: Vliianie predvaritel'nogo khronicheskogo oblucheniia i al'fa-tokoferola na chastotu aberratsii khromosom v kletkakh kostnogo mozga mysheĭ, indutsirovannykh ostrym vozdeĭstviem gamma-lucheĭ.