Posterior cataract induction by UV-B radiation in albino mice.
UV-B radiation (290-320 nm) was very effective at inducing posterior cortical cataracts in mice similar to those seen in the human senile lens. UV-A radiation, in contrast, was at most weakly cataractogenic. The posterior opacities induced by UV-B began to appear 5-6 months after daily exposure to 8 X 10-6 W cm-2 for 12 hr per day or 10-4 W cm-2 for 1 hr per day. Progression was more rapid following the more intense exposure rate. The cataracts developed without any apparent damage to the cornea. A hypothesis of how damage sustained by the epithelium results in posterior opacities is presented.
D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D004307:Dose-Response Relationship, Radiation; D007908:Lens, Crystalline / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D014466:Ultraviolet Rays