[Characteristics of Candida tropicalis D-2 mutants resistant to nystatin, levorin, amphotericin B. I. Frequency of induction depending on the intracellular lipid level and phenotypic characteristics of mutants].
Induction frequency of mutants of Candida tropicalis D-2 strain depends on the number of intracellular lipids and the nature of a chemical mutagen. Para-aminobenzoic acid leads to a decrease in the lethality and mutagenicity of nitrosocompounds, which is stronger expressed in cells with enhanced quantity of lipids. Among nystatin and levorin-resistant mutants obtained independently, the mutants with supersensitivity to other antibiotics were discovered. The majority of mutants possess cross-resistance.
D000666:Amphotericin B / Q000494:pharmacology; D002174:Candicidin / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D050356:Lipid Metabolism; D009154:Mutation; D009761:Nystatin / Q000494:pharmacology; D010641:Phenotype
D009761:Nystatin; D002174:Candicidin; D000666:Amphotericin B
Osobennosti mutantov shtamma Candida tropicalis D-2, rezistentnykh k nistatinu, levorinu, amfoteritsinu B. Soobshchenie I. Chastota induktsii v zavisimosti ot kolichestva vnutrikletochnykh lipidov i fenotipicheskaia kharakteristika mutantov.