Comparative ototoxicity of furosemide and piretanide.
The purpose of these studies was to compare the ototoxicity of piretanide to that of furosemide in the chinchilla. Chinchillas weighing 400 to 700 g were anesthetized with ketamine plus pentobarbital. Endocochlear potential (EP) was measured continuously by the round window approach using glass microelectrodes. Piretanide or furosemide injected through a jugular vein catheter in adults range from 10-100 mg/kg. Little or no change in EP was noted with doses below 15 mg/kg of either diuretic. The overall pattern of decline of EP was rather similar in piretanide-treated and furosemide-injected animals, and it was interesting to find that the dose-ototoxicity response curve for piretanide was similar to that for furosemide. The diuretic effect of equal ototoxic doses of either diuretic was equivalent. Both diuretics cause a decrease of endocochlear potential when applied locally to the round window membrane of the chinchilla as well as by systemic administration. These findings suggest that piretanide and furosemide have approximately the same propensity for ototoxicity.
D000287:Administration, Topical; D000818:Animals; D002682:Chinchilla; D003053:Cochlear Duct / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D007758:Ear, Inner / Q000187:drug effects*; D005665:Furosemide / Q000008:administration & dosage / Q000009:adverse effects*; D007275:Injections, Intravenous; D008564:Membrane Potentials; D012405:Round Window, Ear / Q000187:drug effects; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects*
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; C015451:piretanide