title: Pyloric Campylobacter infection and gastroduodenal disease.
abstract: In 1982, a new spiral Gram-negative bacterium which was similar to those of the genus Campylobacter was isolated from the gastric mucosa of 11 patients with gastritis. From then on, the organism was isolated in a further 114 of 267 patients who underwent antral biopsy in Fremantle Hospital between January 1983 and September 1984. During 1984, the bacterium was cultured from 88% of patients in whom it was detected histologically, and was not cultured from any patient with histologically normal gastric mucosa. The new bacterium, pyloric campylobacter, grew in three days on brain-heart infusion blood-agar at 37 degrees C in an atmosphere with added CO2. All isolates tested were sensitive to penicillin, erythromycin, tetracycline, cephalosporins, gentamicin and bismuth citrate; 80% of isolates were sensitive to metronidazole or tinidazole. It is suggested that pyloric campylobacter infection is a major factor in the causation of dyspeptic disease and peptic ulceration. Antibacterial regimens directed against the bacterium may provide a permanent cure for these chronic disorders.
mesh_terms: D000208:Acute Disease; D002167:Campylobacter / Q000472:pathogenicity; D002169:Campylobacter Infections / Q000382:microbiology* / Q000473:pathology; D004378:Duodenal Diseases / Q000209:etiology / Q000382:microbiology*; D004381:Duodenal Ulcer / Q000209:etiology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D010437:Peptic Ulcer / Q000382:microbiology; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology