Biochemical and morphologic effects of ethanol on fetuses from normally ovulating and superovulated mice.
To further our understanding about the teratogenicity of ethanol, we studied the changes produced by this compound in the incorporation of glucose 14C into several tissue fractions of 12-day mice fetuses and the morphologic alterations present at day 19 of gestation. Furthermore, to determine if the fetal toxicity of ethanol was modified by changes in the characteristics of the pregnancy, we performed similar biochemical and morphologic observations in fetuses from superovulated mice. Maternal ethanol administration caused biochemical alterations in the fetal tissues of both normally ovulating and superovulated mice, but it caused morphologic alterations predominantly in fetuses from superovulated animals. The prevalent morphologic alteration found in ethanol-treated animals was a hemorrhagic lesion dorsal to the lumbar or dorsal vertebrae. These results suggest that superovulation increases the susceptibility of the fetal mice tissues to the teratogenic effects of ethanol.
D000014:Abnormalities, Drug-Induced / Q000378:metabolism; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism* / Q000473:pathology; D005317:Fetal Growth Retardation / Q000139:chemically induced; D005865:Gestational Age; D005947:Glucose / Q000378:metabolism; D006406:Hematoma / Q000139:chemically induced; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D010060:Ovulation; D011247:Pregnancy; D012871:Skin Diseases / Q000139:chemically induced; D013131:Spine; D013347:Subcellular Fractions / Q000378:metabolism; D013480:Superovulation
D000431:Ethanol; D005947:Glucose