The biologically active conformation of ergot alkaloids.
Molecular mechanics and NMR studies of the D ring conformation of ergot alkaloids demonstrate that both D1 and D2 forms may exist in solution. The comparison of the geometric parameters defining the spatial relations between the aromatic moieties and the basic nitrogen of conformationally restricted dopamine analogs, and that of ergolene, shows the D1 conformation to be the bioactive one.
D004298:Dopamine / Q000031:analogs & derivatives; D004873:Ergolines / Q000378:metabolism; D004876:Ergot Alkaloids / Q000378:metabolism; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011954:Receptors, Dopamine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012996:Solutions; D013329:Structure-Activity Relationship
D004873:Ergolines; D004876:Ergot Alkaloids; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012996:Solutions; C048608:9,10-ergolene; D004298:Dopamine