Spleen cell transfusion in the Bio-Breeding/Worcester rat. Prevention of diabetes, major histocompatibility complex restriction, and long-term persistence of transfused cells.
We report that transfusions of RT1u Wistar-Furth (WF) spleen cells prevented spontaneous diabetes in the RT1u BB/W rat while RT1b Buffalo rat spleen cells did not. In addition, donor origin WF T lymphocytes were detected in nondiabetic-susceptible BB/W recipients 5 mo after transfusion. Survival of donor-origin lymphocytes may provide the cellular mechanism by which major histocompatibility complex-compatible WF spleen cell transfusions prevent BB rat diabetes.
D000818:Animals; D002470:Cell Survival; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D008285:Major Histocompatibility Complex; D051381:Rats; D011915:Rats, Inbred BUF; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology* / Q000637:transplantation; D013997:Time Factors