Colonic absorption of 1,2-dimethyl hydrazine (DMH) in the rat.
1,2-Dimethyl hydrazine (DMH) is absorbed in the colon by passive diffusion in the 0.1-5.0 mM concentration range. Absorption of DMH is enhanced by both conjugated and unconjugated bile acids. The presence of hydroxy-fatty acids in the colon markedly increased DMH absorption while fatty acids of different chain length did not influence absorption.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002273:Carcinogens / Q000378:metabolism*; D003106:Colon / Q000378:metabolism*; D004127:Dimethylhydrazines / Q000378:metabolism*; D005227:Fatty Acids / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008763:Methylhydrazines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D002273:Carcinogens; D004127:Dimethylhydrazines; D005227:Fatty Acids; D008763:Methylhydrazines; D019813:1,2-Dimethylhydrazine