Effects of skin storage conditions and concentration of applied dose on [3H]T-2 toxin penetration through excised human and monkey skin.
Penetration of [3H]T-2 toxin through excised human and monkey skin stored at -60 degrees C was faster than through human and monkey skin stored at 4 degrees C, respectively. The permeability of refrigerated human skin was 34% of the permeability of refrigerated monkey skin. Increasing the concentration of [3H]T-2 toxin applied to the refrigerated monkey skin increased the amount of [3H]T-2 toxin penetrating the skin and enhanced the efficiency of penetration. Metabolites of [3H]T-2 toxin were identified in the receptor fluid bathing the dermal side of the excised human and monkey skin.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005615:Freezing; D006801:Humans; D066298:In Vitro Techniques; D008253:Macaca mulatta; D008297:Male; D010539:Permeability; D012034:Refrigeration; D012717:Sesquiterpenes / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D013045:Species Specificity; D013605:T-2 Toxin / Q000378:metabolism* / Q000633:toxicity; D014021:Tissue Preservation; D014316:Tritium
D012717:Sesquiterpenes; D014316:Tritium; D013605:T-2 Toxin