Development of transformed phenotype induced by a human ras oncogene is inhibited by interferon.
Mouse IFN inhibited the development of transformed foci in NIH 3T3 cultures transfected with the viral Ha-MuSV(ras) and Mo-MuSV(mos) oncogenes, or with the human bladder carcinoma ras EJ/T24 DNA. IFN treatment five or seven days after transfection was still effective in inhibiting the oncogenic transformation, but did not inhibit significantly the biochemical transformation induced by pSV2-neo or Ecogpt DNA, so that inhibition of ras-induced transformation was not a result of a general effect on the transfection process. Treatment with IFN did not alter the expression of ras EJ/T24 DNA after the transformed phenotype had been established.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006251:Harvey murine sarcoma virus / Q000235:genetics; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D009857:Oncogenes; D009876:Operon; D010641:Phenotype; D014162:Transfection; D001749:Urinary Bladder Neoplasms / Q000235:genetics
D007370:Interferon Type I