[Reparative regeneration of the liver as a model for the preclinical study of the hepatotropism of anti-alcohol agents].
It has been established that administration of teturam (200 mg/kg) per os once a day for 14 days retards reparative regeneration of the liver in rats following partial hepatectomy and exerts an additional damaging action on the population of regenerating hepatocytes. Administration of potassium orotate (100 mg/kg) per os once a day for 14 days speeds up, on the contrary, organ regeneration. The combined use of the drugs potentiates paradoxically the negative hepatotropic effect of teturam. It is concluded that experimental reparative regeneration of the rat liver can be applied to the assessment of hepatotropism of the antialcoholic drugs.
D000427:Alcohol Deterrents / Q000494:pharmacology*; D000818:Animals; D004221:Disulfiram / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D009963:Orotic Acid / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D000427:Alcohol Deterrents; D009963:Orotic Acid; D004221:Disulfiram
Reparativnaia regeneratsiia pecheni kak model' dlia doklinicheskogo izucheniia gepatotropnosti protivoalkogol'nykh sredstv.