title: Alcohol enhancement of marihuana-induced fetotoxicity.
abstract: In two separate studies marihuana and alcohol were administered, either separately or in combination, to pregnant mice or rats. Control animals were given vehicle only or were nontreated. Marihuana-, alcohol-, and vehicle-treated animals were pair-fed and pair watered with animals given marihuana plus alcohol, to control for drug-related undernutrition. The combination of marihuana and alcohol caused a 100% fetomortality in mice and a 73% fetomortality in rats, whereas neither marihuana nor alcohol alone had any effects on fetomortality that differed significantly from vehicle treatment. These studies suggest a potential danger to pregnancy resulting from the combined use of two commonly used drugs that is far greater than that associated with use of either drug alone.
mesh_terms: D000818:Animals; D001835:Body Weight; D002188:Cannabis; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced* / Q000473:pathology; D005327:Fetal Resorption / Q000139:chemically induced; D051379:Mice; D011247:Pregnancy
chemical_list: D000431:Ethanol