Relative value of oestrogen receptor assay, lactoferrin content, and glucose-6-phosphate dehydrogenase activity as prognostic indicators in primary breast cancer.
Oestrogen receptor content, lactoferrin, hexokinase, and glucose-6-phosphate dehydrogenase levels were measured in cytosol from 25 primary breast cancers and 3 fibroadenomas. Both hexokinase and glucose-6-phosphate dehydrogenase activity were higher in malignant tissue as compared to benign breast lesions. Oestrogen receptor concentration and lactoferrin content failed to predict the development of metastatic disease, while glucose-6-phosphate dehydrogenase activity was significantly higher in cytosol from those tumours which subsequently metastasized compared to those which remained localized.
D000232:Adenofibroma / Q000032:analysis / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000032:analysis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis*; D006593:Hexokinase / Q000032:analysis; D006801:Humans; D007781:Lactoferrin / Q000032:analysis; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*
D011960:Receptors, Estrogen; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D007781:Lactoferrin