[Tumor killing in cooperation with actinomycin D and neutrophils].
Actinomycin D can induce neutrophils at the site of injection, in a similar way to biological response modifiers. Various tumor cells were killed by the cooperative action of actinomycin D with neutrophils (drug-dependent cellular cytotoxicity; DDCC). A soluble factor derived from neutrophils can be substituted for neutrophils, and this factor was detected at the site of neutrophil infiltration.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology*; D007958:Leukocyte Count; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000276:immunology* / Q000473:pathology; D009504:Neutrophils / Q000276:immunology*
D003609:Dactinomycin