Comparison of the effects of testosterone and dihydrotestosterone on the behavior of male cynomolgus monkeys (Macaca fascicularis).
To compare the behavioral effects of testosterone propionate (TP) and diyhdrotestosterone propionate (DHTP) at doses producing plasma levels of androgens within the physiological rage, observations were made on 4 castrated male cynomolgus monkeys during successive 4-week treatment periods while they received 25, 50, 100, 200, 400 and 800 micrograms of either TP or DHTP SC/day in counterbalanced order. Males were tested with each of the same 4 female partners (16 pairs, 1024 1-hr behavior tests). Males were injected at 1600 hr and blood samples were obtained at 0800 hr (256 samples, 456 hormone determinations). Physiological plasma levels of T resulted from the 200 micrograms and 400 micrograms TP treatments, and were associated with significantly increased ejaculatory behavior. Physiological plasma levels of DHT resulted from the 50 micrograms and 100 micrograms DHTP treatments, but there were no changes in ejaculatory behavior over the entire DHTP dose range used. This difference in the behavioral effects of TP and DHTP, not previously reported for a primate, could not be accounted for by the effects of treatment order, season, long-term behavioral testing, female sexual motivation or behavior reflecting the peripheral action of androgens.
D000818:Animals; D013196:Dihydrotestosterone / Q000097:blood / Q000494:pharmacology*; D004542:Ejaculation / Q000187:drug effects; D005260:Female; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009919:Orchiectomy; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013045:Species Specificity; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D013196:Dihydrotestosterone; D013739:Testosterone