Clinical automatic control of neuromuscular blockade.
A simple feedback control technique has been used to automatically deliver pancuronium to anaesthetised surgical patients. The dosage rate is automatically adjusted at 10-second intervals, according to the measured evoked, rectified, integrated electromyogram. When set to demand 80 percent blockade, in 40 patients, the controller maintained blockade at a steady mean level of 72.9 percent (consuming pancuronium at a mean rate of 0.47 microgram/kg/minute). The main clinical practical problems involved protection against electrical noise and the need to spend time setting up the equipment.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000776:Anesthesiology / Q000295:instrumentation*; D001331:Automation; D005246:Feedback; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D010197:Pancuronium