[Synthesis and discharge of secretions in the pancreas of the white rat in the presence of excessive hydrocortisone].
Under conditions of physiological loading at feeding, histologically and radio-autographically (35S-methionine), granuloformation and protein metabolism have been studied in exocrinic pancreocytes in mature white rats under abundant injection of hydrocortisone (6 daily injections, 1 mg per 100 g of body mass). The procedure stimulates formation of zymogen granules, but intensity of the excretion remains unchanged. This results in overfilling the cell with the secretory product, considered as the base of the alterative changes, that in their turn could stimulate the development of the steroid pancreatitis.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects; D004435:Eating; D004792:Enzyme Precursors / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000596:Amino Acids; D004792:Enzyme Precursors; D006854:Hydrocortisone
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