Acetylcholine receptor antibody production by bone marrow cells in a patient with myasthenia gravis.
We briefly report antiacetylcholine receptor antibody production by cultured bone marrow cells (4.9 +/- 0.9 fmol/10(6) cells/wk, mean +/- SD) in a 65-year-old man with myasthenia gravis without thymoma. Lymphocytes from peripheral blood, thymus, and lymph nodes produced less antibody (1.8 +/- 0.1, 0.9 +/- 0.3, and 1.0 +/- 0.4, respectively). The thymus was involuted, and the effect of thymectomy was doubtful 6 months postoperatively.
D000368:Aged; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic