Unusual syndrome among premature infants: association with a new intravenous vitamin E product.
Eight small, premature infants developed an unusual symptom complex of pulmonary deterioration, thrombocytopenia, liver failure, ascites, and renal failure. Five infants died; the health of the other three infants improved and they were discharged from the hospital. This unusual syndrome occurred after introduction of a new intravenous vitamin E product (E-Ferol, alpha-tocopherol acetate) for routine use in the intensive care nursery. Even though no definite conclusion was reached as to its cause, the administration of this intravenous vitamin E product appears to be a significant risk factor.
D058186:Acute Kidney Injury / Q000139:chemically induced; D001201:Ascites / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000473:pathology; D007263:Infusions, Parenteral; D012140:Respiratory Tract Diseases / Q000139:chemically induced; D012306:Risk; D013577:Syndrome; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols