title: The dose-dependent systemic availability of prednisone: one reason for the reduced biological effect of alternate-day prednisone.
abstract: An analysis of the literature was performed, revealing that in many studies both the desired and the undesired effects are decreased in alternate-day prednisone regimens as compared with the daily regimens. In the present report evidence is given that part of the diminished biological effect of dose-spacing regimens is attributable to a decreased total exposure to prednisolone. Following a high dose of 0.8 mg kg-1 of oral prednisone or prednisolone the plasma concentration vs time curves of total prednisolone, unbound prednisolone and prednisolone bound to albumin or transcortin were always less than four times higher than following a low dose of 0.2 mg kg-1 of prednisone or prednisolone. This dose-dependent systemic availability of prednisolone explains partly the diminished biological effect when the same total amount of prednisone or prednisolone is divided into several small doses as opposed to a single oral dose.
mesh_terms: D000284:Administration, Oral; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D011239:Prednisolone / Q000008:administration & dosage / Q000097:blood; D011241:Prednisone / Q000008:administration & dosage / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014156:Transcortin / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D014156:Transcortin; D011239:Prednisolone; D011241:Prednisone