title: Reduction in hepatic lipid and plasma estradiol in estrogenized chicks injected with ascorbic acid.
abstract: Injecting White Leghorn chicks every other day with 20 mg ascorbic acid significantly reduced the increase in liver weight and lipids caused by feeding a diet with 0.1% dienestrol diacetate. In chicks fed two different basal diets containing 0.1% dienestrol diacetate, injecting chicks every other day with 20 mg alpha-tocopherol did not significantly reduce liver weight or lipids while the ascorbic acid injections did. Injecting meat-type chicks implanted with estradiol with 10 mg ascorbic acid daily significantly reduced liver weight, liver lipids, and plasma estradiol, but injecting with 8 mg alpha-tocopherol daily had no significant effect.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004028:Dienestrol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood* / Q000494:pharmacology; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D008055:Lipids; D010636:Phenols; D014810:Vitamin E; D004958:Estradiol; C034731:dienestrol diacetate; D001205:Ascorbic Acid; D004028:Dienestrol