Dose-related beneficial and adverse effects of dietary corticosterone on organophosphorus-induced delayed neuropathy in chickens.
Tri-ortho-tolyl phosphate (TOTP), 360 mg/kg, po, and 0,0'-diisopropyl phosphorofluoridate (DFP), 1 mg/kg sc, were administered to adult White Leghorn chickens 24 hr after they were placed on diets containing 0 to 300 ppm corticosterone. Supplemented diets were continued until clinical signs and lesions of delayed neuropathy appeared. Although low concentrations (less than or equal to 50 ppm) of corticosterone had beneficial effects on TOTP-induced neuropathy, greater than or equal to 200 ppm exacerbated clinical signs in chickens given either TOTP or DFP. Neurotoxic esterase activities 24 hr after TOTP or DFP were less than 20% of values measured in chickens not given organophosphorous compounds. Chickens given 200 ppm corticosterone without TOTP or DFP had significantly elevated activity of plasma cholinesterase and significantly inhibited activity of liver carboxylesterase. Degenerating myelinated fibers were also evident in distal levels of the peripheral nerves of chickens given TOTP or DFP.
D000284:Administration, Oral; D000818:Animals; D001259:Ataxia / Q000139:chemically induced* / Q000517:prevention & control; D001921:Brain / Q000201:enzymology; D002265:Carboxylic Ester Hydrolases / Q000097:blood / Q000378:metabolism; D002645:Chickens; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism; D003345:Corticosterone / Q000494:pharmacology* / Q000627:therapeutic use; D003408:Cresols / Q000633:toxicity*; D004347:Drug Interactions; D007279:Injections, Subcutaneous; D007531:Isoflurophate / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008099:Liver / Q000201:enzymology; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000473:pathology; D051381:Rats; D014317:Tritolyl Phosphates / Q000037:antagonists & inhibitors / Q000633:toxicity*
D003408:Cresols; D014317:Tritolyl Phosphates; D007531:Isoflurophate; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase; D002802:Cholinesterases; D003345:Corticosterone; C025541:tri-o-cresyl phosphate