title: Bone mineral content of limb bones of male weanling rats subjected to 30 and 60 days of simulated increases in body weight.
abstract: The purpose of this study was to subject groups of male rats each to a specific 10% simulated increase in body weight, ranging from 1.1 to 2.0 g. Constant centrifugation was employed. After 30 and 60 days, rats were sacrificed and perfused with 10% BNF. The humerus, radius, ulna, femur, and tibia were removed, cleared of all soft tissues, weighed, decalcified with EDTA, and reweighed. Bone mineral content (BMC) was determined using the formula: [(Wu - Wd) divided by Wu] X 100. Tukey's multiple range test was used. The data suggest that male weanling rats subjected to simulated increases in body weight, within the range used in this study, undergo enhanced BMC, a bimodal curve describing the relationship between BMC and simulated increases in body weight.
mesh_terms: D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000378:metabolism*; D002498:Centrifugation; D005121:Extremities; D006112:Gravitation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014886:Weaning