Vitamin B6 and magnesium.
Administration of vitamin B6 at doses of 1 and 1.5 g/day, for 2-7 weeks, showed that only the high doses increased erythrocyte magnesium. Similarly, magnesium balance studies in subjects receiving 500, 1,000 and 1,500 mg/day of vitamin B6 for 8 days showed that doses of 1 g or less had no effect upon the intestinal absorption of magnesium. In view of the existence of reversible neurological complications in subjects taking 2 g of pyridoxine per day, the use of very high doses of vitamin B6 must be considered as inadvisable, even if effective. A study of the long-term effects, and upon leukocyte magnesium, of doses of 1 g or less would be desirable.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007962:Leukocytes / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011736:Pyridoxine / Q000008:administration & dosage* / Q000627:therapeutic use
D008274:Magnesium; D011736:Pyridoxine