Cis-platin ototoxicity in previously noise-exposed guinea pigs.
The ototoxic effect of Cis-platin on guinea pigs was assessed with frequency-specific brainstem audiometry in the frequency range 0.8-20 kHz. The animals had a noise-induced hearing loss in one ear before Cis-platin treatment. The loss of threshold showed a large inter-individual variability, with a rapid increase above a hypothetic threshold dose. In the noise-exposed ear the total loss was larger, but the additional ototoxic effect was smaller than on the non-exposed side. The hearing loss was independent of pigmentation. in conclusion, there is no potentiation between noise-induced hearing loss and Cis-platin. The data support regular audiometric control before and during Cis-platin treatment for easy detection of incipient hearing loss, before the speech frequency range is affected.
D000818:Animals; D001300:Audiometry, Evoked Response; D002945:Cisplatin / Q000009:adverse effects*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D034381:Hearing Loss / Q000139:chemically induced*; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced*; D006317:Hearing Loss, Noise-Induced / Q000150:complications*; D010858:Pigmentation
D002945:Cisplatin