Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: possible homology with mouse AP-1 and human ACP2.
A genetic locus controlling the electrophoretic mobility of an acid phosphatase in the rat (Rattus norvegicus) is described. The locus, designed Acp-2, is not expressed in erythrocytes but is expressed in all other tissues studied. The product of Acp-2 hydrolyzes a wide variety of phosphate monoesters and is inhibited by L(+)-tartaric acid. Inbred rat strains have fixed either allele Acp-2a or allele Acp-2b. Codominant expression is observed in the respective F1 hybrids. Backcross progenies revealed the expected 1:1 segregation ratio. Possible loose linkage was found between the Acp-2 and the Pep-3 gene loci at a recombination frequency of 0.36 +/- 0.06.
D000135:Acid Phosphatase / Q000235:genetics*; D000483:Alleles; D000818:Animals; D008040:Genetic Linkage; D014644:Genetic Variation; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D051381:Rats / Q000235:genetics*; D014018:Tissue Distribution
D007527:Isoenzymes; D000135:Acid Phosphatase