Modification of fatty acid composition in adipocyte plasma membranes by an oral treatment with a new antidiabetic agent, AS-6, in genetically obese diabetic mice, db/db.
Male 12-week-old C57BL/KsJ db/db mice were treated for 1 week with a dietary admixture of an experimental antidiabetic agent, AS-6 (4-O-carboxymethylascochlorin, 0.1%). The fatty acid composition of the adipose tissue and its plasma membranes in the treated mice was compared with that in untreated db/db mice and their lean littermates. The results indicate that, when compared with the lean, the db/db adipose tissue and its plasma membrane are extremely rich in nonessential fatty acids, and AS-6 treatment modifies the fatty acyl composition only in the membranes in which 16:1 and 18:1 increase and C18 decreases.
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D002462:Cell Membrane / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005227:Fatty Acids / Q000032:analysis*; D006016:Glycolates / Q000627:therapeutic use*; D008563:Membrane Lipids / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity
D005227:Fatty Acids; D006016:Glycolates; D008563:Membrane Lipids; C043832:4-O-carboxymethylascochlorin