title: Hyperthermia enhances X ray cell killing in normal and homozygous and heterozygous ataxia telangiectasia human cells.
abstract: Two homozygous and heterozygous ataxia telangiectasia (AT) cell strains were compared to normal human cells for heat and radiation responses. The thermal sensitivities to one hour heating at 42.0 degrees C were comparable in the five cell strains. Thermal enhancement of radiosensitivity occurred in both homo- and hetero-zygous AT cell strains and was comparable to the thermal enhancement observed in the normal cell strain. Normal cells recovered during incubation at 37.0 degrees C between the two treatments of heat and X rays while homozygous AT cells showed no recovery. The heterozygous cell strains showed only a slight sequence dependence for heat and radiation sensitivity.
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics / Q000503:physiopathology*; D002470:Cell Survival / Q000528:radiation effects*; D002478:Cells, Cultured; D004260:DNA Repair; D006579:Heterozygote; D006720:Homozygote; D006358:Hot Temperature; D006801:Humans; D014965:X-Rays