[Increased body resistance to the toxic action of cyclophosphane through the use of short-term hypoxic hypoxia].
Experiments were carried out on 535 SHK albino male mice weighing 24.0 +/- 4.0 g to study the modifying effect of gas hypoxic mixture containing 10.0 +/- 1.0% O2 and 90.0 +/- 1.0% N2 (GHM-10) on cyclophosphane toxicity after intraperitoneal injection of 800, 1000, 1200, 1400, 1600, 1800, and 2000 mg/kg. Before the injection, the animals were kept in a hypoxic medium for 30 min, which reduced mortality rate. It is found that human organism can endure GHM-10 quite well.
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004780:Environment, Controlled; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
D003520:Cyclophosphamide
Povyshenie rezistentnosti organizma k toksicheskomu deĭstviiu tsiklofosfana s pomoshch'iu kratkovremennoĭ gipoksicheskoĭ gipoksii.