title: Cytopathogenic cerebrospinal fluid from neurological and psychiatric patients.
abstract: Cerebrospinal fluids (CSFs) were examined for the presence of a cytopathogenic component by an in vitro assay. No abnormal proteins were detected in CSF which produced cytopathic effects. The cytopathic effect was associated with high-molecular-weight material which was resistant to enzyme treatment. The effect persisted after extensive ultraviolet irradiation. The presence of the cytopathic effect was associated with increased CSF enolase levels.
mesh_terms: D002478:Cells, Cultured; D002555:Cerebrospinal Fluid / Q000382:microbiology*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003588:Cytopathogenic Effect, Viral; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D014461:Ultracentrifugation; D014466:Ultraviolet Rays
chemical_list: D002556:Cerebrospinal Fluid Proteins; D010751:Phosphopyruvate Hydratase