title: Secretion of bromide by the canine prostate.
abstract: Four dogs with surgically produced prostatic fistulas were given single oral doses of 1.13 gm of sodium bromide daily for five consecutive days. Two days later the mean (+/- SE) serum level of bromide was 28.0 +/- 4.0 meq/L and the serum chloride level had decreased from a pretreatment value of 112.5 +/- 1.0 meq/L to 86.5 +/- 3.7 meq/L; in the basal prostatic secretion, the mean prostatic fluid to serum (PF/S) ratios for bromide and chloride were 0.56 +/- 0.15 and 0.53 +/- 0.11, respectively, and were not different (P greater than 0.05, paired t-test); at higher rates of secretion provoked by intravenous pilocarpine the corresponding PF/S ratios of 1.48 +/- 0.04 and 1.32 +/- 0.01 were significantly different (P less than 0.05, paired t-test). It is concluded that the processes involved in forming the basal and pilocarpine-induced prostatic secretions must differ and that the ability of the chloride-transporting system to transport bromide is slightly greater than that for chloride. Because it may impair sperm motility, bromide secreted in prostatic fluid potentially could adversely affect reproduction.
mesh_terms: D000818:Animals; D001965:Bromides / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D002712:Chlorides / Q000378:metabolism; D004285:Dogs; D005402:Fistula / Q000378:metabolism; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D011469:Prostatic Diseases / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D017670:Sodium Compounds
chemical_list: D001965:Bromides; D002712:Chlorides; D017670:Sodium Compounds; D010862:Pilocarpine; D012964:Sodium; C027938:sodium bromide