Effect of surgery and efferent duct ligation on testicular blood flow and testicular steroidogenesis in the rat.
A moderate reduction in testicular blood flow was observed in both testes 24 h after unilateral efferent duct ligation without any corresponding change in testosterone secretion as indicated in the peripheral blood, in testicular venous blood, or in testicular tissue fluid. At 21 days a pronounced unilateral decrease in blood flow was associated with the extensive degeneration of tubules in the testis on the ligated side. These changes were also associated with decreased testosterone secretion by the testis on the ligated side, although Leydig cell function was not abolished since testosterone in the tissue increased rather than decreased. It is therefore concluded that testicular blood flow may play an important role in the changes of testosterone secretion that follow unilateral efferent duct ligation.
D000818:Animals; D008026:Ligation; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013737:Testis / Q000033:anatomy & histology / Q000098:blood supply* / Q000378:metabolism / Q000601:surgery; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood; D013997:Time Factors
D013739:Testosterone