[Dantrolene in the treatment of life-threatening psychiatric disease pictures. A contribution to the therapy of the malignant neuroleptic syndrome and acute febrile catatonia].
The malignant neuroleptic syndrome and acute febrile catatonia are life-threatening psychiatric disorders which frequently are treated in intensive care units outside psychiatric departments. Their manifestations are very similar to those of anaesthesia-specific malignant hyperthermia. The three syndromes have in common signs of increased muscle metabolism. Dantrolene, a specific drug in the treatment of malignant hyperthermia, has been used successfully several times recently in the treatment of the malignant neuroleptic syndrome. One such case is reported. In a 23-year-old man with signs of acute febrile catatonia parenteral dantrolene and electroconvulsive shocks succeeded in counteracting the symptoms of the abnormally raised muscle metabolism.
D000328:Adult; D001480:Basal Ganglia Diseases / Q000188:drug therapy*; D003620:Dantrolene / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis; D009459:Neuroleptic Malignant Syndrome / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012560:Schizophrenia, Catatonic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D003620:Dantrolene
Dantrolen in der Behandlung lebensbedrohlicher psychiatrischer Krankheitsbilder. Ein Beitrag zur Therapie des malignen neuroleptischen Syndroms und der akuten febrilen Katatonie.