title: Development and persistence of class-specific antibodies in the serum and nasopharyngeal washings of rubella vaccinees.
abstract: Serial samples of serum and nasopharyngeal washings were obtained from 43 volunteers given one of four rubella vaccines (HPV77.DE5, RA27/3, To-336, and Cendehill) and from nine naturally infected volunteers. Rubella-specific serum IgG was detected by radioimmunoassay for up to 12 years in all but one vaccinee, and booster responses occurred in 23.3% of vaccinees. Rubella-specific serum IgA was detected in 37 (90.2%) of 41 vaccinees one year after vaccination but in only five (45.5%) of 11 vaccinees tested 10-12 years after vaccination. Low levels of rubella-specific IgM detected by M-antibody capture radioimmunoassay persisted in seven volunteers--four of them HPV77.DE5 vaccinees--four more than one year after vaccination. Rubella-specific nasopharyngeal IgA was detected for up to five years after natural infection or vaccination with RA27/3 but for no longer than three years among Cendehill, HPV77.DE5, and To-336 vaccinees. Nasopharyngeal IgG antibodies were detected less frequently and at lower levels.
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D009305:Nasopharynx / Q000276:immunology; D012411:Rubella Vaccine / Q000276:immunology*; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012411:Rubella Vaccine