Severe liver injury due to phenelzine with unique hepatic deposition of extracellular material.
Severe acute and chronic hepatic damage occurred in a white man who had taken phenelzine sulfate (Nardil) 45 mg daily for 70 days. Liver biopsy showed a mixed hepatitic and cholestatic pattern with extracellular deposition of a unique homogeneous collagenous substance. Portal cirrhosis developed and has persisted. The patient was found to have a "rapid acetylator phenotype" and high rate of metabolism of antipyrine. These innate factors may have predisposed to hepatic injury due to phenelzine.
D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005110:Extracellular Space; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010624:Phenelzine / Q000009:adverse effects*
D010624:Phenelzine