[Changes in the phospholipid-phospholipid ratio and lipid peroxidation in the heart muscle in experimental myocardial infarction before and after combined antioxidant therapy].
Dynamics of quantitative relations between neutral and acid phospholipids in rabbit myocardium was studied with simultaneous registration of lipid free radical oxidation (estimated by malonic dialdehyde content) in NADP-dependent system of oxidation within various periods after simulation of myocardial infarction in the animals treated with alpha-tocopherol and sodium nucleinate 2 and 25 mg/kg of body mass, respectively) and did not receiving the drugs. The complex treatment led to normalization of qualitative and quantitative relations between phospholipids in the impaired myocardium and to decrease the lipid peroxidation in myocardium infarction.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009696:Nucleic Acids / Q000008:administration & dosage / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D008054:Lipid Peroxides; D009696:Nucleic Acids; D010743:Phospholipids; D014810:Vitamin E; D008315:Malondialdehyde; C013683:sodium nucleinate
Izmenenie fosfolipid-fosfolipidnykh sootnosheniĭ i perekisnoe okislenie lipidov v serdechnoĭ myshtse pri éksperimental'nom infarkt miokarda do i posle provedeniia kombinirovannoĭ antioksidantoterapii.