Reproductive tract abnormalities in female mice treated neonatally with tamoxifen.
Immature female mice of the NMRI strain were treated with 20 micrograms/day of tamoxifen or vehicle for the first 3 days after birth. At 90 days of age, vaginas, uteri, and ovaries were examined histologically. A benign epithelial change, vaginal adenosis characterized by abnormal growth of columnar epithelium with glandular structures, was found in all of the tamoxifen-treated mice. Anatomic anomalies such as hypospadias, cervical hypoplasia, uterine hypoplasia, and absence of corpora lutea also were commonly observed. Such abnormalities were not found in the control mice.
D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D002584:Cervix Uteri / Q000002:abnormalities; D003338:Corpus Luteum / Q000002:abnormalities; D005260:Female; D005836:Genitalia, Female / Q000002:abnormalities*; D007021:Hypospadias / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D013629:Tamoxifen / Q000633:toxicity*; D014599:Uterus / Q000002:abnormalities; D014621:Vagina / Q000002:abnormalities
D013629:Tamoxifen