[Effect of indomethacin and voltaren on glutathione oxidation and reduction in the liver of white rats].
It has been established that oral administration of indomethacin (2.5 mg/kg) to albino rats for one week leads to a decline in the level of reduced and an increase in the level of oxidized glutathione with a simultaneous activation of liver glutathione reductase and glutathione peroxidase. Administration of the drug for two weeks makes the indicators under study return in the main to normal. The raising of the drug dose up to 5 mg/kg makes the total content of glutathione fall at the expense of its reduced form. The activity of the enzymes significantly rises in all the observation periods (days 1-5 after administration). The use of voltaren in doses of 2.5 and 5 mg/kg does not produce any action on the glutathione forms or glutathione reductase and glutathione peroxidase activity in the liver.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; D004008:Diclofenac; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D007213:Indomethacin
Vliianie indometatsina i vol'tarena na okislenie i vosstanovlenie glutationa v pecheni belykh krys.