Tissue deposition of bisantrene in B16 melanoma tumor-bearing mice.
Single doses of 14C-labeled bisantrene, a new antitumor agent, were administered intravenously at 10 and 100 mg/kg to mice bearing intraperitoneally implanted B16 melanoma. At 24 hr after dosing, the tumors contained relatively high drug concentrations as compared to most of the other tissues. The concentrations averaged 2.4 and 28.3 micrograms/g tumor and the tumor/blood concentration ratios were 40/1 and 29/1 for the low and high doses, respectively.
D000818:Animals; D000873:Anthracenes / Q000097:blood / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002460:Cell Line; D008297:Male; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D014018:Tissue Distribution
D000873:Anthracenes; D000903:Antibiotics, Antineoplastic; D002250:Carbon Radioisotopes; C031404:bisantrene