Bacterial inoculum and the activity of antimicrobial agents.
Experimental and clinical infections have concentrations of bacteria that are greater than the concentrations used in the laboratory for the determination of in vitro activity. When realistic concentrations are used, the antibiotic activity is reduced. The optimum selection of antibiotics may require a re-examination of the laboratory procedures for the determination of sensitivity data.
D000005:Abdomen; D000038:Abscess / Q000188:drug therapy / Q000382:microbiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods*; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents