title: Erythrocytic and leukocytic responses to cadmium poisoning in a freshwater fish, Puntius conchonius Ham.
abstract: Chronically sublethal concentrations of cadmium caused conspicuous hematological anomalies in the cyprinid fish, Puntius conchonius. Exposure to 0.63 and 0.84 mg/liter cadmium chloride (1/20 and 1/15 of 96-hr LC50) induced morphological aberrations in mature erythrocytes including cytoplasmic vacuolation, hypochromia, deterioration of cellular membrane, basophilic stippling of cytoplasm, clumping of chromatin material and extrusion of nuclei, and schistocytosis. Anomalous basophils and monocytes were also encountered though less frequently. Decreased erythrocyte counts, hemoglobin and hematocrit values were also associated with chronic cadmium poisoning. The mean corpuscular hemoglobin and mean corpuscular volume increased (30 days) but mean corpuscular hemoglobin concentration showed no obvious change. A significant thrombocytopenia (90 days), elevated small lymphocyte and basophil populations, and a mild neutropenia were manifested in the cadmium-exposed fish. Large lymphocytes were not significantly affected.
mesh_terms: D000818:Animals; D002105:Cadmium Poisoning / Q000097:blood / Q000662:veterinary*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D005393:Fish Diseases / Q000097:blood*; D005399:Fishes / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000473:pathology; D008297:Male
chemical_list: D006454:Hemoglobins