title: Effects of ingestion of hibernia and Prudhoe Bay crude oils on hepatic and renal mixed function oxidase in nestling herring gulls (Larus argentatus).
abstract: Oral administration of Prudhoe Bay crude or Hibernia crude to nestling herring gulls increased the hepatic cytochrome P-450 content 4-fold. Concomitantly, there was an increase in various mixed-function oxidase and phase II enzyme activities. 7-Ethoxyresorufin O-deethylase was elevated 19-fold, benzo(a)pyrene 3-hydroxylase 6-fold, aniline hydroxylase 3-fold, and aminopyrine N-demethylase and uridine diphosphate glucuronyl transferase 2-fold. There was no change in reduced glutathione S-transferase activity. Renal mixed-function oxidase activities were also elevated. Herring gull livers contained very low levels of DT-diaphorase activity which was inducible 3- to 5-fold by oil administration.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001717:Birds; D003580:Cytochromes / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects*; D005648:Fuel Oils / Q000032:analysis / Q000633:toxicity*; D008401:Gas Chromatography-Mass Spectrometry; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010578:Petroleum / Q000633:toxicity*; D014166:Transferases / Q000378:metabolism
chemical_list: D003580:Cytochromes; D005648:Fuel Oils; D010578:Petroleum; D006899:Mixed Function Oxygenases; D014166:Transferases