title: [Complexes of the N-terminal disulfide branch point of fibrin with fibrinogen].
abstract: Investigation of fibrin N-terminal disulphide knot (N-DSK) binding with fibrinogen (F) showed, that the F-N-DSK-complex represents growing polymer structure which is soluble at early polymerization stage and forms a solid phase during the further growth. This complex is characterized by constant stoichiometry expressed by formula F (N-DSK)2. A model of the complex structure as a regular copolymer of fibrinogen and N-DSK is proposed, in which neighbouring fibrinogen molecules are clamped with two N-DSK molecules. Such copolymer was never described. Since its formation is caused by specific D-E interdomain binding, it may be considered as a peculiar analogue of fibrin polymer.
mesh_terms: D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D005337:Fibrin; D005340:Fibrinogen; D008958:Models, Molecular; D011108:Polymers
chemical_list: D011108:Polymers; D005337:Fibrin; D005340:Fibrinogen
vernacular_title: Kompleksy N-kol'tsevogo disul'fidnogo uzla fibrina s fibrinogenom.