Familial nonspherocytic hemolytic anemia in poodles.
Nonspherocytic hemolytic anemia, characterized by marked reticulocytosis, hepatosplenomegaly, hemosiderosis of reticuloendothelial organs and bone marrow myelofibrosis, and osteosclerosis, was diagnosed in 5 related Poodles. The unremitting anemia was clinically evident by 1 year of age, and was fatal as early as 3 years of age. Despite intense diagnostic endeavors including RBC fragility studies, RBC enzyme assays, and hemoglobin electrophoresis, the cause of this nonspherocytic hemolytic anemia remains to be determined.
D000745:Anemia, Hemolytic, Congenital / Q000662:veterinary*; D000746:Anemia, Hemolytic, Congenital Nonspherocytic / Q000097:blood / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000235:genetics*; D004285:Dogs; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D006461:Hemolysis; D008297:Male; D010375:Pedigree; D012156:Reticulocytes / Q000166:cytology