[Comparative quantitative assessment of a carcinogenic effect taking intercurrent mortality into account].
The paper discusses the advantages offered by the statistical evaluation of experimental carcinogenic effect with due regard to mortality from concomitant pathology. The method used complex tables of contingents and analysis was carried out separately in 3 groups of tumors--independent of mortality, fatal and incidental ones. The method was compared with standard procedures which do not take care of the said mortality rate (table of contingents 2 X 2 and precise procedure of Fisher). The data on development of 1,2-dimethylhydrazine-induced tumors of the skin, uterus and ovaries in 5 strains of mice were used in the study.
D000818:Animals; D004127:Dimethylhydrazines; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000401:mortality; D010051:Ovarian Neoplasms / Q000139:chemically induced / Q000401:mortality; D012878:Skin Neoplasms / Q000139:chemically induced / Q000401:mortality; D013223:Statistics as Topic; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000401:mortality
D004127:Dimethylhydrazines
Sravnitel'naia kolichestvennaia otsenka kantserogennogo éffekta s uchetom interkurrentnoĭ smertnosti.