Effect of polyethylene glycol 400 on the penetration of drugs through human cadaver skin in vitro.
The effect of polyethylene glycol 400 on the penetration of drugs through human cadaver skin is reported. Polyethylene glycol 400 was used in various concentrations in the donor and the receptor compartments. It was observed that polyethylene glycol 400 had significant effects on the penetration rates of compounds, both when used in the donor as well as in the receptor solutions. These effects were barrier specific and are related to the alteration of the skin structure and the mass flow of water.
D000893:Anti-Inflammatory Agents / Q000378:metabolism; D004058:Diffusion; D006143:Guanabenz / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008566:Membranes / Q000378:metabolism; D000077431:Oxaprozin; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011422:Propionates / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D012995:Solubility
D000893:Anti-Inflammatory Agents; D004364:Pharmaceutical Preparations; D011422:Propionates; D011092:Polyethylene Glycols; D006143:Guanabenz; D000077431:Oxaprozin