The oocytic origin of dysgerminoma.
An early dysgerminoma, found by chance in a grossly normal ovary, was completely blocked and multiply sectioned. It was found to have a mainly cortical location, being densest in the subtunical and adjacent zones where primordial follicles are normally most numerous, and to be associated with a reduction of the oocyte count in tumor-involved areas. An oocytic origin of the tumor is inferred from these findings and from other data, including the age incidence, available in the literature.
D000293:Adolescent; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003338:Corpus Luteum / Q000473:pathology; D004407:Dysgerminoma / Q000473:pathology*; D005260:Female; D006801:Humans; D009865:Oocytes / Q000166:cytology*; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery