title: Sublingual buprenorphine for premedication and postoperative pain relief in orthopaedic surgery.
abstract: The effect of sublingual buprenorphine (Temgesic) as a premedicant and for postoperative pain relief compared with morphine/pethidine was studied in 50 patients scheduled for elective surgery of the knee joint. Twenty-five patients received buprenorphine 0.4 mg sublingually 1 h before surgery and the same dose on demand postoperatively. Twenty-five patients were given morphine intramuscularly (7.5 mg or 10 mg to females and males respectively) 1 h preoperatively. This group received pethidine (75 mg) intramuscularly on demand postoperatively. All the patients were anaesthetized with halothane N2O/O2 after induction with thiopentone. No significant differences were found with regard to sedation, dizziness, nausea and vomiting during the study period. Emergence shivering, confusion and restlessness just after termination of the operation were equal in the two groups. In the recovery room, however, there was a higher frequency of shivering (P less than 0.05) in the morphine group. During the first 24 h postoperatively the buprenorphine group was given an average of 3.8 doses compared with 2.3 in the pethidine group (P greater than 0.05). It is concluded, that buprenorphine sublingually is as good as morphine intramuscularly for premedication and therefore should be recommended to patients who wish to avoid injections. For postoperative pain relief the initial dose of buprenorphine should be given intravenously. Only minor and unimportant side effects were seen.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008614:Meperidine / Q000009:adverse effects / Q000627:therapeutic use; D009019:Morphinans / Q000627:therapeutic use*; D009020:Morphine / Q000009:adverse effects / Q000627:therapeutic use; D009985:Orthopedics; D010149:Postoperative Pain / Q000188:drug therapy*; D011229:Preanesthetic Medication
chemical_list: D006993:Hypnotics and Sedatives; D009019:Morphinans; D002047:Buprenorphine; D009020:Morphine; D008614:Meperidine