[Differentiation of the antipsoriatic and phototoxic effectiveness of topical PUVA therapy].
Using a 0.075% 8-methoxypsoralen solution, minimal phototoxic doses and improvement of psoriasis lesions were investigated in 15 patients suffering from chronic stationary psoriasis. The time interval between topical 8-methoxypsoralen application and long-wave ultraviolet light irradiation was increased stepwise. The mean minimal phototoxic dose declined with increasing time interval and reached its minimum 2 h after 8-methoxypsoralen application. In spite of that, antipsoriatic efficiency was maximal 15 min after application. In order to obtain a favorable relationship between antipsoriatic efficiency and unwanted side effects when using topical PUVA treatment, irradiation should be started 15 min after 8-methoxypsoralen application.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000379:methods*; D011565:Psoriasis / Q000188:drug therapy*
Differenzierung von antipsoriatischer und phototoxischer Effektivität bei topischer PUVA-Therapie.