Chromosome changes with time in lymphocytes after occupational exposure to toluene.
Chromosome analyses were carried out in peripheral lymphocytes of 27 workers exposed to toluene in a rotogravure plant. At the time of blood sampling all of them had not been exposed to toluene for at least 4 months up to 5 years. Up to 2 years after cessation of exposure to toluene a higher incidence of chromatid-type aberrations could be observed than in controls. After longer post-exposure periods the aberration yields can no longer be distinguished from background level. No differences were revealed in SCE frequencies of smoking or non-smoking workers post toluene exposure compared with the corresponding controls.
D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes; D009784:Occupational Diseases / Q000139:chemically induced*; D012854:Sister Chromatid Exchange; D012907:Smoking; D013997:Time Factors; D014050:Toluene / Q000633:toxicity*
D014050:Toluene