Promotional effects of testosterone and dietary fat on prostate carcinogenesis in genetically susceptible rats.
Germfree (GF) Lobund strain Wistar (LW) rats, fed vegetable diet L-485, have developed prostate adenocarcinomas spontaneously (10% incidence) at average age 34 months. Conventional LW rats, implanted with testosterone at age 4 months, developed a higher incidence of prostate cancer after an average interval of 14 months: 24% had developed gross tumors, and 40% when it included microscopic tumors. Preliminary results indicate that testosterone-treated LW rats that were fed the same diet, which was supplemented with corn oil up to 20% fat, developed prostate cancer after intervals of 6-12 months. Aged GF Sprague-Dawley (SD) rats have not developed prostate cancer spontaneously. Conventional SD rats fed diet L-485 and treated with testosterone developed only prostatitis. Experimental designs should consider genetic susceptibility as a basic prerequisite for studies on experimental prostate cancer.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000209:etiology*; D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects*; D004195:Disease Models, Animal; D008297:Male; D008722:Methods; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000209:etiology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects
D004041:Dietary Fats; D013739:Testosterone