Genetic toxicological testing of some dyes by the micronucleus test.
Three widely used dyes, acridine orange, blue VRS and fast green FCF were administered to male mice in order to study the induction of gross chromosomal anomalies using the micronucleus test. All 3 compounds were shown to be clastogenic.
D000165:Acridine Orange / Q000009:adverse effects*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004305:Dose-Response Relationship, Drug; D008086:Lissamine Green Dyes / Q000009:adverse effects*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D012394:Rosaniline Dyes / Q000009:adverse effects*
D008086:Lissamine Green Dyes; D009153:Mutagens; D000644:Quaternary Ammonium Compounds; D012394:Rosaniline Dyes; C007704:Fast Green FCF; D000165:Acridine Orange; C008769:sulfan blue