[Changes in the microviscosity of lipid bilayer membranes of various malignant cells and tumor transplantability].
It is shown that cholesterol incorporation into the membranes of Zajdel hepatoma cells, lymphoblast leukemia cells L1210 and into those of ovary tumour causes an increase in the membrane phospholipid bilayer microviscosity measured by pyrene as fluorescent probe. The increase in the membrane lipid microviscosity resulted in a decrease in the activity of Na,K-ATPase and 5-nucleotidase of the tumour cells. After the injection of tumour cells with an increase of cholesterol/phospholipid ratio we observed an increase of the life-span of experimental animals as compared to the control groups.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D008051:Lipid Bilayers; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D010647:Phenyl Ethers / Q000494:pharmacology*; D051381:Rats; D014783:Viscosity
D008051:Lipid Bilayers; D008563:Membrane Lipids; D010647:Phenyl Ethers; C048426:1,5-((3,3'-dimethylphosphate)diphenoxy)-3-oxapentane; D002784:Cholesterol
Izmenenie mikroviazkosti lipidnogo bisloia membran nekotorykh zlokachestvennykh kletok i perevivaemost' opukholeĭ.