title: Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study.
abstract: Restless legs syndrome was present in nine members of a family over a span of five generations. In three subjects, the diagnosis was confirmed by all-night sleep recordings and concomitant EMG. Two of these three subjects also had periodic movements in sleep. The frequency of leg movements decreased from wakefulness to stages 1 and 2 non-REM sleep. There was an increase of free dopamine and homovanillic acid in CSF of the propositus. Clonazepam effectively controlled restless legs in the propositus and his mother.
mesh_terms: D000328:Adult; D001679:Biogenic Amines / Q000032:analysis; D002998:Clonazepam / Q000627:therapeutic use; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D012148:Restless Legs Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D012890:Sleep; D014851:Wakefulness
chemical_list: D001679:Biogenic Amines; D002998:Clonazepam