Evidence for the existence of 5-hydroxytryptamine receptors, which are not of the 5-HT2 type, mediating contraction of rabbit isolated basilar artery.
In the rabbit isolated basilar artery the contractile action of 5-hydroxytryptamine (5-HT) was little affected by high concentrations of ketanserin (1.0 X 10(-6) M) indicating that 5-HT-receptors other than those of the 5-HT2-type were involved. The contractile action of 5-HT was mimicked by methysergide and 5-carboxamidotryptamine (5-CT) with equipotent concentration ratios (5-HT = 1) of about 22 and 0.6 respectively. This profile is characteristic of that in the dog saphenous vein which contains a 5-HT receptor type that may be described as '5-HT1-like'.
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D011817:Rabbits; D011985:Receptors, Serotonin / Q000032:analysis* / Q000187:drug effects; D012701:Serotonin / Q000031:analogs & derivatives / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
D011985:Receptors, Serotonin; D012701:Serotonin; C047087:5-carboxamidotryptamine; D008784:Methysergide