title: Event-related brain potentials (P300) and neuropsychological deficit in patients with focal brain lesions.
abstract: Sixteen patients with chronic focal brain lesions were investigated with an acoustic P300 test and psychological tests of spatial abilities (Maze Tracing Speed Test, Form Board Test), cognitive speed (Sequential Number Connection Test), categorization (Figure Sorting Test), verbal fluency and vigilance. Neither the psychological battery nor P300 analysis discriminated frontal from retrorolandic brain lesions. Abnormalities of P300 significantly correlated with impairments in those psychological tests which had a spinal component in common. We suggest that abnormality of the P300 with focal brain damage rather indicates higher mental function impairment than direct effects of the lesion.
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology* / Q000523:psychology; D001930:Brain Injuries / Q000503:physiopathology / Q000523:psychology; D002544:Cerebral Infarction / Q000503:physiopathology / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D013037:Spatial Behavior; D014705:Verbal Behavior / Q000502:physiology