Analysis of mutagenic imidazo[4,5-f]quinolines and -quinoxalines (IQ compounds). Comparison of electrochemical and ultraviolet detection.
Two synthetic imidazoquinolin-2-amines (IQ and MeIQ) and two imidazoquinoxalin-2-amines (MeIQx and 4,8-DiMeIQx), all known potent mutagens, have been separated by reversed-phase HPLC and detected by two methods - UV detection and electrochemical (EC) detection. The limits of detection were found to be 2.5 pmoles for UV detection and 0.5-1.5 pmoles for electrochemical detection.
D002853:Chromatography, Liquid; D007093:Imidazoles / Q000032:analysis*; D009153:Mutagens / Q000032:analysis*; D011804:Quinolines / Q000032:analysis; D011810:Quinoxalines / Q000032:analysis*
D007093:Imidazoles; D009153:Mutagens; D011804:Quinolines; D011810:Quinoxalines