[Tissue polypeptide antigen in gynecological cancer].
Serum tissue polypeptide antigen (TPA), CEA and IAP were measured simultaneously in cervical cancer, corpus cancer and ovarian cancer. TPA levels were increased (more than 110 U/1) in 39% (32/82) of the cervical cancer and in 46% (6/12) of the corpus cancer patients, respectively. In ovarian cancer, TPA levels were elevated (146 U/1 or higher) in 64% (13/22). The positive rate of CEA was somewhat lower than that of TPA and LAP levels were as high as TPA. Moreover, TPA levels were correlated in clinical course. In immunohistochemical examination, TPA was present in cancer cells and absent in normal tissue.
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000097:blood; D010051:Ovarian Neoplasms / Q000276:immunology*; D010704:Phorbols / Q000032:analysis*; D013755:Tetradecanoylphorbol Acetate / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*; D014594:Uterine Neoplasms / Q000276:immunology*
D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; D010704:Phorbols; C030193:immunosuppressive acidic protein; D013755:Tetradecanoylphorbol Acetate