[Radiotherapy, using metronidazole, of regional lymph node metastases of cancer of the oral mucosa].
Altogether 67 patients with oral mucosa cancer metastases to the regional lymph nodes were given a split course of gamma-beam therapy with traditional dose fractionation and dynamic fractionation. Radiotherapy in the presence of metronidazole radiosensitization was given to 40 patients. Metronidazole was administered per os 3 = 4 h before irradiation with fractions I, III and V of each phase of a split course. A single dose of metronidazole was 5 g/m2, a summary dose 30 g/m2. Radiotherapy with metronidazole resulted in a 2-year cure of 17.5 +/- 6% of the patients. The therapy was the most effective in patients with metastases of diameter up to 2 cm. The results of therapy of oral mucosa cancer metastases to the regional lymph nodes were better in the use of the dynamic fractionation regimen.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000188:drug therapy / Q000532:radiotherapy*; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D011838:Radiation-Sensitizing Agents; D008795:Metronidazole
Luchevaia terapiia s metronidazolom metastazov v regionarnye limfaticheskie uzly raka slizistoĭ obolochki polosti rta.