title: TL 333, a benzhydro[g]quinoline, stimulates both D-1 and D-2 dopamine receptors: implications for the selectivity of LY 141865 towards the D-2 receptor.
abstract: TL 333, (trans-N-ethyl-6,7-dihydroxyoctahydrobenzo[g]-quinoline), stimulates both D-1 and D-2 dopamine receptors. In contrast, LY 171555 (the active enantiomer of the selective D-2 agonist LY 141865) and LY 149632 stimulate only D-2 receptors. The structural differences between TL 333, LY 171555 and LY 149632 are discussed with regards to understanding the basis for the selective D-2 agonist activity of LY 171555 or LY 149632.
mesh_terms: D000818:Animals; D004873:Ergolines / Q000494:pharmacology*; D005399:Fishes; D066298:In Vitro Techniques; D011804:Quinolines / Q000494:pharmacology*; D019257:Quinpirole; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004873:Ergolines; D011804:Quinolines; D011954:Receptors, Dopamine; D019257:Quinpirole; C044940:N-ethyl-6,7-dihydroxyoctahydrobenzo(g)quinoline