Multicompartment kinetic models for lead. I. Bone diffusion models for long-term retention.
The long-term retention of lead in bone poses a number of difficulties for the usual multicompartment models. The use of diffusion models based on exchange of lead between blood in canaliculi and the crystalline bone of the osteon allows a linear compartmental approximation suitable for statistical estimation of kinetic parameters in peripheral compartments. The model is applied to lead retention by beagle dogs.
D000818:Animals; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism*; D004058:Diffusion; D004285:Dogs; D006801:Humans; D007700:Kinetics; D007854:Lead / Q000378:metabolism*; D008954:Models, Biological
D007854:Lead