title: Periodic leg movements in sleep: effect of clonazepam treatment.
abstract: Periodic leg movements in sleep were diagnosed in 8 patients with insomnia and in 12 patients with hypersomnia. Polysomnography did not reveal any difference in the number of leg movements in these groups, the mean duration of a leg movement, or the number of activity epochs. Those with insomnia, however, had a shorter intermovement interval than those with hypersomnia, with more leg movements in each activity epoch. Treatment with 0.5 to 2 mg clonazepam improved subjective complaints and decreased the number of leg movements without affecting the intermovement interval or movement duration.
mesh_terms: D000328:Adult; D000368:Aged; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D006970:Disorders of Excessive Somnolence / Q000150:complications; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D010507:Periodicity; D012649:Self Concept; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D001570:Benzodiazepinones; D002998:Clonazepam