Effects of arterial pH and HCO-3 concentration on HCO-3 secretion in the isolated blood-perfused dog pancreas.
We examined the effects of plasma pH and plasma HCO-3 concentration on pancreatic HCO-3 secretion in resting state and in stimulated state by secretin, pancreozymin or dopamine, using the isolated blood-perfused dog pancreas. Secretin- or pancreozymin-induced HCO-3 secretion was sensitive to changes in both plasma pH and HCO-3 concentration. On the other hand, neither plasma pH nor plasma HCO-3 concentration affected dopamine-induced HCO-3 secretion and spontaneous HCO-3 secretion. These results suggest that secretin- or pancreozymin-induced pancreatic HCO-3 secretion is induced by the active H+-pump, but dopamine-induced or spontaneous pancreatic HCO-3 secretion may be caused by different mechanisms.
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D001784:Blood Gas Analysis; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010477:Perfusion; D012633:Secretin / Q000494:pharmacology
D001639:Bicarbonates; D012633:Secretin; D002766:Cholecystokinin; D004298:Dopamine