[Immunomodulation by antitumor antibiotics].
Antibiotics exhibiting immunomodulatory activities were found among antitumor antibiotics. These antibiotics had antileukemic activity. Neothramycin and mazethramycin, which are classified as anthramycin-group antibiotics, activated macrophages so that they became antitumor effector cells. Aclacinomycin and oxanosine inhibited generation of suppressor cells in tumor-bearing mice and oxanosine enhanced antitumor effector cells. Therapy using spergualin produced specific antitumor immunity in cured mice. The immunomodulatory activities of auromomycin and bactobolin were also reported.
D015250:Aclarubicin / Q000031:analogs & derivatives*; D000818:Animals; D000876:Anthramycin / Q000031:analogs & derivatives / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects*; D007939:Leukemia L1210 / Q000188:drug therapy / Q000276:immunology*; D051379:Mice; D009279:Naphthacenes / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D012263:Ribonucleosides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001570:Benzodiazepinones; D006146:Guanidines; D009279:Naphthacenes; D010455:Peptides; D012263:Ribonucleosides; C011157:aclacinomycins; C001666:auromomycin; D000876:Anthramycin; C012453:neothramycins; C027073:mazethramycin; C033797:spergualin; D015250:Aclarubicin; C032886:oxanosine