title: Resin hemoperfusion for chloramphenicol intoxication.
abstract: A case report of a three kilogram, four month infant who received excessive doses of chloramphenicol for the treatment of bacterial meningitis is presented. The child was treated with resin hemoperfusion (XAD-4) to reduce her serum chloramphenicol concentration. Her treatment was complicated by hypocalcemia and thrombocytopenia. During hemoperfusion a mean clearance of chloramphenicol of 27.4 ml/min was achieved. This represents a significant improvement over normal body clearance (4.7 ml/min/kg) in pediatric patients. We conclude that using hemoperfusion is an effective modality which may be used as an adjunct to supportive therapy when there is a need to increase the body clearance of chloramphenicol.
mesh_terms: D002701:Chloramphenicol / Q000506:poisoning* / Q000627:therapeutic use; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007223:Infant; D007475:Ion Exchange Resins; D008583:Meningitis, Haemophilus / Q000188:drug therapy; D011137:Polystyrenes; D011145:Polyvinyls
chemical_list: D007475:Ion Exchange Resins; D011137:Polystyrenes; D011145:Polyvinyls; C012101:XAD-4 resin; D002701:Chloramphenicol