Evaluation of two distinctive beta-carbolines on serotonin binding in human platelets.
6-MeOTHBC binds to both high and low affinity receptors in human platelets. The beta-carboline is less active than chlorimipramine at the low affinity site, and it is weaker than methysergide, a known 5-HT antagonist, at the high affinity site. The other beta-carboline, B-CCE, is not active at either receptor in platelets. The data supports the view that platelets could be used as a limited model for studying 5-HT-ergic neurons.
D001792:Blood Platelets / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008784:Methysergide / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012701:Serotonin / Q000097:blood*
D002243:Carbolines; D007211:Indoles; D011985:Receptors, Serotonin; C002272:6-methoxytryptoline; D012701:Serotonin; C024915:beta-carboline-3-carboxylic acid ethyl ester; D008784:Methysergide