Carcinogenicity of 1-methyl-3(p-chlorophenyl)-1-nitrosourea and its 1-methyl trideuterated derivative in rats.
The carcinogenic activity of 1-methyl-3(p-chlorophenyl)-1-nitrosourea (Cl-MPNU) and its 1-methyl trideuterated analog (Cl-MPNU-d3) was compared by intragastric administration to hooded rats of equimolar doses of both compounds. A 100% frequency of forestomach tumors was observed in both groups. However, the mean latency period of the animals treated with Cl-MPNU-d3 was significantly longer (P less than 0.01). The results suggest the occurrence of a deuterium isotope effect in nitrosoureas but not as distinct as in nitrosamines.
D000818:Animals; D002273:Carcinogens; D007441:Intubation, Gastrointestinal; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D013274:Stomach Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; C022033:N-methyl-N'-(4-chlorophenyl)-N-nitrosourea; D008770:Methylnitrosourea