[Effect of low doses of internal irradiation resulting from the administration of 75Se- and 35S-labeled compounds on the cellular immune response].
The administration to rats of radioactive preparations. 75Se- selenomethionine, 35S-methionine or sodium 75Se-selenite in the amounts creating the absorbed dose in the body of 0.5 Gy suppressed the delayed hypersensitivity reaction as was registered 1-12 months after the injection. The delayed hypersensitivity was tested in vitro by the method of inhibimacrophage spreding inhibition. The degree of suppression of the cellular immune response depended upon the type of the compound administered, of which the radionuclide was a component, and upon characteristics of radiation spectrum of the radionuclide.
D000818:Animals; D007111:Immunity, Cellular / Q000528:radiation effects*; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage*; D012645:Selenomethionine / Q000008:administration & dosage*; D013462:Sulfur Radioisotopes / Q000008:administration & dosage*
D013462:Sulfur Radioisotopes; D012645:Selenomethionine; D008715:Methionine; D020887:Selenious Acid; D012643:Selenium
Vliianie malykh doz vnutrennego oblucheniia, formiruiushchikhsia pri vvedenii v organizm soedinenii 75Se i 35S, na kletochnyĭ immunnyĭ otvet.