Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema.
The effect of an extract of Ginkgo biloba was studied on cerebral edema in rats intoxicated with triethyltin chloride (TET). Brains of TET-treated rats showed elevated water and sodium levels and a significant increase in the sodium/potassium ratio. Animals treated with TET plus the extract did not show water and electrolyte changes. The course of intoxication and treatment was studied light- and electron-microscopically. A severe edema with extensive vacuolization was seen in the cerebral and cerebellar white matter. Morphometric measurements revealed a significant decrease in these manifestations of the cytotoxic edema when the animals were treated with an extract of Ginkgo biloba. Thus, we conclude that this extract has a protective effect on the development of a cytotoxic edema in the white matter of the brain.
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D001929:Brain Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D011188:Potassium / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000032:analysis; D014267:Triethyltin Compounds / Q000037:antagonists & inhibitors; D014867:Water / Q000032:analysis
D010936:Plant Extracts; D014267:Triethyltin Compounds; D014867:Water; D012964:Sodium; D011188:Potassium