[Induction of drug resistance to sarcolysine in plasmacytoma line MORC/406].
A sarcolysine-resistant strain of mouse plasmacytoma MOPC/406 was obtained in experiments on 250 BALB/c mice. The initial plasmacytoma strain is highly sensitive to sarcolysine. When administered in doses of 10 and 5 mg/kg it increases the lifespan up to 50 days (the observation period). In the course of resistance induction by incremental doses of sarcolysine, a highly resistant plasmacytoma strain was obtained. In the 20th generation of inoculations with the use of sarcolysine administration of 10 mg/kg (intraperitoneally) provided only a 18% increase in the lifespan, whereas the dose 5 mg/kg stimulated the growth of plasmacytoma. The strain obtained preserves its resistance under cryoconservation in liquid nitrogen, being a model that permits one to study resistance, cross-resistance and approaches to its overcoming.
D000818:Animals; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D008558:Melphalan / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000188:drug therapy* / Q000401:mortality
D008558:Melphalan
Induktsiia lekarstvennoĭ rezistentnosti k sarkolizinu na shtamme plazmotsitomy MORC/406.