Synthesis and evaluation of N,N'-bis(arylsulfonyl)hydrazines as antineoplastic agents.
Several N,N'-bis(arylsulfonyl)hydrazines, with the potential to function as biological methylating agents, were synthesized and evaluated for antineoplastic activity against the L1210 leukemia and other transplanted rodent tumors. In general, the N-methyl-N,N'-bis(arylsulfonyl)hydrazines that possess the capacity to generate an alkylating species under physiological conditions showed significant antineoplastic activity, while N,N'-bis(phenylsulfonyl)-hydrazine and N-methyl-N,N'-dibenzoylhydrazine were inactive.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D006834:Hydrazines; D013450:Sulfones