[Gastroduodenal tolerability of indomethacin and acetaminophen. A comparative endoscopic study in healthy subjects].
The effect of a 5- and 10-day treatment with indometacin and acemetacin (Rantudil) on the gastroduodenal mucosa was endoscopically evaluated in 16 healthy volunteers. In a randomised double-blind cross-over fashion the volunteers received 50 mg t.i.d. indometacin as well as 60 mg t.i.d. acemetacin. Acemetacin evoked after 5 and 10 days significantly less gastroduodenal lesions than indometacin. Possible reasons for this apparently better tolerability of acemetacin in man are discussed.
D000082:Acetaminophen / Q000009:adverse effects*; D000328:Adult; D004311:Double-Blind Method; D004361:Drug Tolerance; D004378:Duodenal Diseases / Q000139:chemically induced*; D005753:Gastric Mucosa / Q000187:drug effects; D005773:Gastroscopy; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007413:Intestinal Mucosa / Q000187:drug effects; D013272:Stomach Diseases / Q000139:chemically induced*
D000082:Acetaminophen; D007213:Indomethacin
Gastroduodenale Verträglichkeit von Indometacin und Acemetacin. Eine endoskopische Vergleichsstudie bei gesunden Probanden.