title: Persistent 24-h variations of urinary 6-hydroxy melatonin sulphate and cortisol in Antarctica.
abstract: Bright light (2000-3000 lux) of sufficient intensity to suppress human melatonin secretion, acts as a strong zeitgeber in the entrainment of circadian rhythms in man. In polar conditions, light of this intensity is not experienced for several weeks during the winter. The entrainment of human circadian rhythms, in particular that of melatonin, is clearly of interest in these circumstances. Urinary 6-hydroxy melatonin sulphate (aMT6s) is a good index of melatonin secretion in man. In a limited study of seven male volunteers living on an Antarctic base the overall 24-h rhythm of aMT6s excretion was maintained at four different times of year (spring, summer, autumn and winter) and no significant seasonal effects were noted. Cortisol excretion, appeared to be markedly affected by the season although other factors such as social and environmental stress cannot be discounted. These observations suggest that in the absence of a strong light-dark cycle melatonin production may be entrained by other factors.
mesh_terms: D000864:Antarctic Regions; D002940:Circadian Rhythm; D003624:Darkness; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D008027:Light; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine; D012621:Seasons
chemical_list: D008550:Melatonin; C012365:6-hydroxymelatonin; D006854:Hydrocortisone