Long-term histologic follow-up of phenol face peels.
Deep phenol peels were done on 11 middle-aged white women with severe actinic damage. Subsequently, face lifts were carried out after periods of 1.5 to 20 years. This made it possible to obtain a full-thickness specimen extending several centimeters on either side of the border between peeled and unpeeled skin. In contrast to the markedly abnormal elastotic appearance of unpeeled skin, a new band of connective tissue 2 to 3 mm in width was laid down in the subepidermal region. Fine elastic fibers formed a dense network in the band of regenerated collagen. The disarray and cytologic abnormalities of sun-damaged epidermis were also largely corrected. Melanocytes were not eliminated, but melanin synthesis was evidently impaired, accounting for the bleaching effects. The effects of a phenol peel are very long lasting and adequately account for the effacement of wrinkles and obliteration of actinic keratoses, mottling, and freckling.
D000328:Adult; D002615:Chemexfoliation / Q000009:adverse effects; D004817:Epidermis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D019800:Phenol; D010636:Phenols / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D013472:Sunlight / Q000009:adverse effects
D010636:Phenols; D019800:Phenol