Plasma nor1-chlorpromazine concentrations: effects of age, race, and sex.
Plasma nor1-chlorpromazine (nor1-CPZ) and chlorpromazine concentrations were measured by gas chromatography--mass fragmentometry in 15 inpatients receiving stable doses of chlorpromazine. Nor1-CPZ concentrations averaged 20% of chlorpromazine concentrations and were highly correlated with them. Relative concentrations of nor1-CPZ increased with age. Nor1-CPZ concentrations per milligram dose were higher in black than in white patients.
D000328:Adult; D000367:Age Factors; D002746:Chlorpromazine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012737:Sex Factors
C029699:norchlorpromazine; D002746:Chlorpromazine