Effect of cephalexin and tetracycline on galactose absorption in rat small intestine.
The effects of cephalexin and tetracycline HCl on D-galactose absorption in rat small intestine were investigated. Both antibiotics inhibited D-galactose uptake into isolated intestinal mucosa in a dose-dependent fashion. In vivo studies showed that cephalexin and tetracycline HCl reduced D-galactose absorption and that the transport defect was not reversible on cessation of antibiotic perfusion. Both the active and passive components of D-glactose absorption were inhibited by the antibiotics tested. Furthermore, both drugs reduced mucosa O2 consumption and inhibited D-galactose absorption when they were perfused in a contiguous loop. We conclude that the diminished D-galactose transport by rat small intestine after tissue exposure to either cephalexin or tetracycline HCl appears to be in part due to an insufficient energy supply.
D000818:Animals; D002506:Cephalexin / Q000494:pharmacology*; D005690:Galactose / Q000378:metabolism*; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D010695:Phlorhizin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000494:pharmacology*; D013997:Time Factors
D010695:Phlorhizin; D013752:Tetracycline; D002506:Cephalexin; D005690:Galactose