Anaphylactic-like reaction of small intestinal epithelium in parasitized guinea-pigs.
Antigens derived from Trichinella spiralis were used to challenge, in vitro, sensitized jejunum from infected guinea-pigs while monitoring ion transport properties of the tissue. Antigen challenge resulted in dose-dependent increases in trans-epithelial electrical potential difference and short circuit current. Both antigen-stimulated electrical alterations and Schultz-Dale contractions were demonstrated in small intestinal tissue after the passive transfer of immune serum containing anti-trichinella homocytotropic antibodies.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004553:Electric Conductivity; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D007413:Intestinal Mucosa / Q000276:immunology / Q000503:physiopathology; D007421:Intestine, Small / Q000276:immunology*; D008297:Male; D008564:Membrane Potentials; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D014235:Trichinellosis / Q000276:immunology* / Q000503:physiopathology
D000947:Antigens, Helminth; D007106:Immune Sera; D010047:Ovalbumin