title: Pattern of the primary and secondary antibody responses elicited by TNP-LPS in mice.
abstract: Trinitrophenylated lipopolysaccharide (TNP-LPS) at high doses (30 micrograms) induces thymus-independent IgM and IgG anti-TNP responses. At low doses (0.3 microgram) it elicits only an IgM anti-TNP response. TNP-LPS primes for a secondary response of IgG type only when given at high doses (30 micrograms): this response is thymus dependent.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D051379:Mice; D009578:Nitrobenzenes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014301:Trinitrobenzenes / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D009578:Nitrobenzenes; D014301:Trinitrobenzenes