title: Reduced thromboplastin activity in blood monocytes and reduced sensitivity to stimuli in vitro of blood monocytes from pregnant women.
abstract: The thromboplastin activity in blood monocytes from 18 normal third trimester pregnant women has been compared with a group of 20 healthy non-pregnant women. The thromboplastin activity in unstimulated monocytes from the normal pregnant group was on average 40% of the activity in the non-pregnant group (P less than 0.01). In endotoxin stimulated monocytes, the thromboplastin activity was also significantly lower in the pregnant group as compared to the non-pregnant group (P less than 0.001). Fibrinogen and factors V, VII and VIII were significantly higher in the pregnant than in the non-pregnant group, whereas no difference was observed in AT-III, prekallikrein and alpha 2-antiplasmin levels.
mesh_terms: D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D013925:Thromboplastin / Q000378:metabolism*
chemical_list: D001779:Blood Coagulation Factors; D004731:Endotoxins; D013925:Thromboplastin