title: Influence of different dietary fatty acid sources on erythrocyte lipids and plasma and liver essential fatty acids in hamsters fed ethanol.
abstract: Hamsters fed ethanol were given three different dietary sources of essential fatty acids; safflower oil, evening primrose oil (both mainly n-6 fatty acids) or linseed oil (mainly n-3 fatty acids). After 7 weeks, plasma, erythrocyte and liver lipids and fatty acids were analyzed. Plasma and liver lipids were not significantly different in the ethanol-fed hamsters compared to the controls. Erythrocyte total phospholipid was increased only in the ethanol-fed groups given n-6 but not n-3 fatty acids. Some fatty acid changes induced by ethanol were predictable, e.g. lower 20:4 n-6 in hamsters fed n-6 fatty acids, but others were not predictable, e.g. higher 22:6 n-3 in all the ethanol-fed groups. The effect of ethanol on hamster lipids and fatty acid composition appears dependent on the predominant class of dietary fatty acids.
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D004041:Dietary Fats / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005228:Fatty Acids, Essential / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism*; D010743:Phospholipids / Q000097:blood
chemical_list: D004041:Dietary Fats; D005228:Fatty Acids, Essential; D008055:Lipids; D010743:Phospholipids; D000431:Ethanol; D002784:Cholesterol