Lack of oestrogen-like activity in commercially refined vegetable oils.
Commercially refined corn, safflower, sunflower and soya-bean oils, as well as well as lard and beef tallow, were fed to pre-pubertal female mice at a level of 5 or 20% of a semi-synthetic diet to assess whether they exhibited any oestrogen-like activity, as measured by changes in uterine weight or in the ratio of uterine weight to body weight. No measurable oestrogen-like activity was observed, in contrast to the effects in positive-control animals treated with 5, 10 or 15 ppb diethylstilboestrol. This finding contradicts an earlier report in the literature. It also shows that oestrogen-like activity in a commercially refined oil is not likely to be a variable in the complex mechanism of the dietary modulation of induced breast-tumour growth.
D000818:Animals; D003314:Corn Oil; D004041:Dietary Fats / Q000009:adverse effects; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000209:etiology; D051379:Mice; D008813:Mice, Inbred ICR; D009821:Oils / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils; D013024:Soybean Oil; D000074242:Sunflower Oil; D014599:Uterus / Q000187:drug effects
D004041:Dietary Fats; D004967:Estrogens; D009821:Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D013024:Soybean Oil; D003314:Corn Oil