Effects of glycerol on cochlear frequency selectivity in patients with Menière's disease.
During transtympanic electrocochleography, action potential (AP) tuning curves were derived as a measure of cochlear frequency selectivity. In 18 out of 21 patients with symptoms of Menière's disease, a poor frequency selectivity was observed. In 12 subjects the effects on frequency selectivity of oral glycerol were measured, and in 5 patients AP tuning curves indicated an improvement in sharpness of tuning by a factor of 1.5-2.5. These changes started approximately 30 min after oral glycerol administration. In 2 subjects there was a deterioration in AP tuning. In 5 patients no significant changes were observed.
D000200:Action Potentials / Q000187:drug effects; D001299:Audiometry; D001300:Audiometry, Evoked Response; D003051:Cochlea / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology; D006801:Humans; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology; D013065:Speech Intelligibility
D005990:Glycerol