Intramuscular ceruletide does not affect food intake in obese and non-obese human subjects.
Intramuscular ceruletide or placebo was given in a randomized double-blind crossover design to 12 non-obese and 12 obese individuals, 30 min before a palatable lunch meal. No significant effects were found on the amount of food intake or the hunger ratings in any group. Although rapid CCK or ceruletide infusions have been found in some studies to reduce food intake in man and animals, slow infusions have increased food intake. Under the present study conditions, the moderate rate of release of ceruletide from intramuscular depots did not affect the food intake.
D000328:Adult; D002108:Ceruletide / Q000627:therapeutic use*; D004435:Eating / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects*; D005260:Female; D006801:Humans; D006815:Hunger / Q000187:drug effects; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D012527:Satiation / Q000187:drug effects
D002108:Ceruletide