Ambulatory monitoring of blood pressure and arrhythmias by non-invasive methods in hypertensive patients treated with metoprolol.
Non-invasive ambulatory monitoring of blood pressure and ECG was employed to assess the 24-hour profile of blood pressure and arrhythmias in 20 out-patients aged 31-69 years. The technique was further used to measure the therapeutic response to 100 mg once daily of the cardioselective beta-blocker metoprolol. The basal ambulatory examinations revealed that all 20 patients had a mean 24-hour blood pressure of greater than 160/90 mm Hg, corresponding to a mean arterial pressure (MAP) of greater than 113 mm Hg. In 16 of the 20 patients (80%) the mean 24-hour MAP was reduced to below 113 mm Hg. Addition of diuretics in the remaining four patients further decreased the mean 24-hour MAP to less than 113 mm Hg, which confirmed by a third ambulatory examination. The ECG recordings in the initial ambulatory study revealed severe degrees of ventricular arrhythmias in 7 patients. After treatment with metoprolol, all of them presented an improved ECG picture.
D000553:Ambulatory Care; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008991:Monitoring, Physiologic / Q000379:methods*
D008790:Metoprolol