Comparative in vitro activity of sanguinarine against oral microbial isolates.
MICs of sanguinarine were determined for 52 oral reference strains and 129 fresh isolates from human dental plaque. Sanguinarine was found to completely inhibit the growth of 98% of the isolates at a concentration of 16 micrograms/ml.
D000470:Alkaloids / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D053119:Benzophenanthridines; D003470:Culture Media; D003773:Dental Plaque / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D007546:Isoquinolines; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D053119:Benzophenanthridines; D003470:Culture Media; D007546:Isoquinolines; C005705:sanguinarine