Abnormal neuronal growth in the little (lit) cerebrum.
Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the Golgi-Cox method modified by Ramon-Moliner, however, the pyramidal neuron was found to have short primary dendrites with sparse branchings. This result was confirmed in sections stained for neuron-specific enolase. Therefore, we conclude that growth hormone has an independent action on neuronal development.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D001921:Brain / Q000166:cytology / Q000201:enzymology / Q000254:growth & development* / Q000648:ultrastructure; D002455:Cell Division; D003712:Dendrites / Q000648:ultrastructure; D005260:Female; D013006:Growth Hormone / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains / Q000033:anatomy & histology / Q000254:growth & development*; D009044:Motor Cortex / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis
D013006:Growth Hormone; D010751:Phosphopyruvate Hydratase