[Toxicological study of the long-term effects of the antioxidant dodecyl gallate on albino rats].
Toxicity of the antioxidant dodecyl gallate was studied in 150-day experiments on male white rats. The antioxidant was administered intragastrically in doses of 250, 50 and 10 mg/kg bw. The general status and behavior of the animals, the survival rate, weight gain, peripheral blood, the amount of urea, total serum protein, soluble proteins of the liver and kidneys, and activity of enzymes (AST, ALT, LDH, SDH, glucose-6-phosphate dehydrogenase, alkaline and acid phosphatase of the serum, liver and kidneys, the weight of the internal organs) were studied over time, followed by morbid anatomy studies. Quantitative determination of serum lipids (total fats, total cholesterol, esterified cholesterol, free cholesterol, triglycerides, free fatty acids, triglycerides plus free fatty acids, and phospholipids) was made on the 150th day after the onset of experiments. When administered in a dose of 250 mg/kg, dodecyl gallate produced death of the animals and an increase in the content of triglycerides plus free fatty acids, a decrease in the weight of the spleen and morphological alterations in the liver, kidneys and spleen. The dose 50 mg/kg was also toxic. It brought about changes in the activity of serum and liver AST, an increase in the content of TF, TG, FFA, TG plus FFA and phospholipids, a reduction in the weight of the spleen and pathological changes in the liver, kidneys and spleen. The dose 10 mg/kg is regarded as liminal.
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000633:toxicity*; D001284:Atrophy; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced; D005707:Gallic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects*; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D007687:Kidney Tubules, Proximal / Q000473:pathology; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D000975:Antioxidants; C008259:lauryl gallate; D005707:Gallic Acid
Toksikologicheskoe izuchenie antiokislitelia dodetsilgallata v usloviiakh dlitel'nogo vozdeĭstviia na belykh krys.