Changes in density of muscarinic cholinergic receptor by adrenergic denervation with guanethidine.
The effects of chronic adrenergic denervation with guanethidine on muscarinic cholinergic receptors (mAChR) were investigated by binding of L-3H-quinuclidinyl benzilate (3H-QNB). Guanethidine treatment decreased the amount of mAChR from 102 to 87 fmoles/mg protein in the heart and from 444 to 388 fmoles/mg protein in the small intestine, but increased it from 223 to 282 fmoles/mg protein in the vas deferens, without changes in its characteristics. These findings suggested that adrenergic innervation has different influences on the mAChR population in different tissues.
D000818:Animals; D006145:Guanethidine / Q000494:pharmacology*; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D013563:Sympathectomy, Chemical; D014649:Vas Deferens / Q000378:metabolism
D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D006145:Guanethidine