Antiinflammatory action of hydrosoluble dimethyltriazenes on the carrageenin-induced edema in guinea pigs.
The antiinflammatory activity of three hydrosoluble aryldimethyltriazenes has been examined on the carrageenin induced edema in guinea pig. The administration of equitoxic dosages of p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK) and p-(3,3-dimethyl-1-triazeno)sulfonic acid sodium salt (DM-SO3Na) 1 h after carrageenin application, causes 4 h later a similar and statistically significant reduction of paw swelling by about 40% whereas, p-alanylphenyl-3,3-dimethyl-1-triazeno (DM-ALA(OH)) is inactive. Of the two active compounds, DM-COOK displays interesting properties, being rapidly active and causing a peak of inhibition higher than that caused by DM-SO3Na. The antiinflammatory activity of DM-COOK is comparable with that caused by 5 mg/kg indomethacin and 200 mg/kg phenylbutazone. However, DM-COOK, unlike indomethacin, causes an inhibition of leukocyte migration into the peritoneal cavity induced by casein treatment, thus indicating a different mechanism of action. This effect needs clarification and seems not to be correlated to cytotoxicity of the drug for migrating white blood cells, as evidenced by "in vitro' examination.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan; D002364:Caseins / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006168:Guinea Pigs; D007962:Leukocytes / Q000502:physiology; D010529:Peritoneal Cavity; D012995:Solubility; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D002364:Caseins; D014226:Triazenes; C030838:1-(4-carboxyphenyl)-3,3-dimethyltriazene; D002351:Carrageenan