Alterations in lymphocyte subpopulations in copper-deficient mice.
Analyses of cell surface determinants of splenocytes from copper-deficient C58 mice indicate alterations in lymphocyte subpopulation characteristics. Both the absolute number and the relative percentage of surface immunoglobulin-bearing (B) cells from copper-deficient mice were significantly greater than those from copper-supplemented controls. The relative percentage of Thy 1.2-positive (T) cells was decreased, and the decrease was most prominent within the Lyt 1-positive (helper) T-cell subset. The functional responsiveness of both B cells and T cells was decreased in copper deficiency.
D000818:Animals; D002455:Cell Division; D003300:Copper / Q000172:deficiency*; D007109:Immunity; D008214:Lymphocytes / Q000145:classification*; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology; D013163:Splenomegaly / Q000209:etiology
D008934:Mitogens; D003300:Copper