A dose-response model for teratological experiments involving quantal responses.
This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D001699:Biometry; D004787:Environmental Pollution; D005260:Female; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011247:Pregnancy; D011336:Probability; D013723:Teratogens
D013723:Teratogens