[Effect of histamine H2 receptor blockers on hepatic elimination of drugs].
In an investigation is proved that already after a treatment with the histamine-H2-receptor blocker Cimetidine (Altramet) lasting 14 days the elimination of Antipyrine is significantly delayed. In 14 male patients suffering from peptic ulcer the half-life period of Antipyrine (t50) was 8.6 +/- 0.6 h, whereas in the second test after 14 days it was 13 +/- 0.8 h. The systemic clearance (Cltot) was estimated with 78 +/- 11.3 ml X min-1 before treatment and with 40.8 +/- 3.6 ml X min-1 after treatment. It is pointed out that under a therapy with Cimetidine preparations and simultaneous application of medicaments which were eliminated by the so-called phase-I-reaction a hepatic interaction may occur.
D000328:Adult; D000983:Antipyrine / Q000097:blood*; D002927:Cimetidine / Q000009:adverse effects* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D010437:Peptic Ulcer / Q000097:blood / Q000188:drug therapy*
D002927:Cimetidine; D000983:Antipyrine
Der Einfluss von Histamin-H2-Rezeptorenblocker auf die hepatische Elimination von Arzneimitteln.