[Inhibition of NDV replication by theophylline].
Theophylline is said to produce an inhibiting effect on the replication of the Newcastle disease virus in chick embryo fibroblast cultures when used in conc. of 1 mM. When the cultures are treated with theophylline 24 hours prior to their infection or following one-hour adsorption the virus titer is lowered in the process of replication by about 2 lg as against the titer when the virus is replicated in theophylline-free cultures. The inhibiting effect consists in blocking or arresting the production of mature virions.
D000327:Adsorption; D000818:Animals; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D009522:Newcastle disease virus / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology*; D013997:Time Factors; D014771:Virion / Q000187:drug effects; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects*
D013806:Theophylline
Inkhibirane replikatsiiata na NDV s teofilin.