Indium 111 toxicity in the human lymphocyte.
Indium-labeled lymphocytes were examined for response to a variety of mitogens, ability to synthesize immunoglobulins, mitotic index, and presence of chromosome aberrations at a range of exposures from 0.2 to 500 muCi/10(8) cells. Results of all four tests were found to be abnormal when the lymphocytes were labeled with 111In activities well within those employed for diagnostic testing.
D002470:Cell Survival; D002869:Chromosome Aberrations / Q000528:radiation effects; D002875:Chromosomes / Q000528:radiation effects; D006801:Humans; D007204:Indium / Q000633:toxicity*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000528:radiation effects*; D008940:Mitotic Index; D011868:Radioisotopes / Q000633:toxicity*
D011868:Radioisotopes; D007204:Indium