Orthophenylphenol mutagenicity in a human cell strain.
Orthophenylphenol (OPP), a widely used fungicide, induced ouabain-resistant (OuaR) mutants in a ultraviolet (UV)-sensitive human RSa cell strain and the frequencies increased in a dose-related fashion. OPP was a more potent mutagen than UV at doses related to equal survival. These results suggest that OPP has a mutagenic activity and that further experiments on this chemical are warranted.
D001713:Biphenyl Compounds / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004351:Drug Resistance; D006801:Humans; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects* / Q000528:radiation effects; D010042:Ouabain / Q000494:pharmacology
D001713:Biphenyl Compounds; D010042:Ouabain; C004369:2-phenylphenol