[Acute isoniazid poisoning].
Acute isoniazid intoxication is characterised by high mortality and vomiting, seizures, coma and metabolic acidosis as main symptoms. Besides isoniazid, its metabolites may also cause neurotoxicity, as demonstrated in a patient. Delayed onset of neurotoxicity should be considered. The therapy of intoxication with special emphasis on high-dose vitamin B6 application is discussed.
D000138:Acidosis / Q000139:chemically induced; D003128:Coma / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000139:chemically induced; D005260:Female; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000097:blood / Q000506:poisoning*; D008657:Metabolic Clearance Rate; D011736:Pyridoxine / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced
D011736:Pyridoxine; D007538:Isoniazid
Akute Isoniazid- Vergiftung.