Unsuccessful treatment of disseminated protothecosis in a dog.
Systemic protothecosis was diagnosed in a 7-year-old dog that had only ocular manifestations. During the 3-month course of disease, a variety of drugs was administered, including amphotericin B, gentamicin, and ketoconazole. The ocular signs initially abated, but subsequently worsened during this period. The dog was found dead 3 months after initial examination, and systemic protothecosis was confirmed at necropsy.
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D002701:Chloramphenicol / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy*; D004285:Dogs; D005128:Eye Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D005839:Gentamicins / Q000627:therapeutic use; D007239:Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary; D007654:Ketoconazole / Q000627:therapeutic use; D011525:Prototheca
D005839:Gentamicins; D002701:Chloramphenicol; D000666:Amphotericin B; D007654:Ketoconazole