The influence of AZQ on the DNA distribution of human cerebral tumours in short-term culture.
The influence of AZQ, a chemotherapeutic agent, on the DNA-distribution of human cerebral tumours in short-term culture was studied by means of a MPV II cytofluorometer. The cell cultures were exposed to increasing concentrations of AZQ during 5 days. The results showed that AZQ has no cell phase-specific activity. The influence on the DNA-distribution varied considerably in the examined tumours. It is hypothesised that the effect of AZQ might depend upon the initial DNA-distribution of human cerebral tumours, hyperdiploid tumours being more vulnerable.
D001388:Aziridines / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D016227:Benzoquinones; D001932:Brain Neoplasms / Q000032:analysis* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D046508:Culture Techniques; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D011003:Ploidies
D001388:Aziridines; D001389:Azirines; D016227:Benzoquinones; D004273:DNA, Neoplasm; C029108:diaziquone