Monitoring therapeutic drug levels in older patients.
Reduced renal function is the most important variable to consider in reducing dosage of drugs that are excreted largely unchanged in the urine, eg, cardiac glycosides and aminoglycoside antibiotics. Generally, therapeutic concentrations listed for specific drugs are equivalent for both younger and older adults. The major change in treatment of the elderly is lowering the customary dose to compensate for decreases in metabolism or clearance.
D000042:Absorption; D000328:Adult; D000368:Aged; D000375:Aging; D001775:Blood Circulation; D002302:Cardiac Output; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism* / Q000652:urine; D011485:Protein Binding
D004364:Pharmaceutical Preparations