Chlorpromazine inhibition of electron transport in Azotobacter vinelandii membranes.
Chlorpromazine was a potent inhibitor of O2-dependent malate oxidation, but not of H2 oxidation in Azotobacter vinelandii membranes. However, chlorpromazine did not significantly affect the activity of malate reductase or the reduction of cytochromes c and d. In the presence of chlorpromazine, cytochrome o failed to form a complex with CO. The site of action of chlorpromazine seems to be in the cytochromes c to cytochrome o branch, the pathway utilized by malate, succinate and NADH, but not by H2.
D001395:Azotobacter / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D003580:Cytochromes / Q000378:metabolism; D004579:Electron Transport / Q000187:drug effects*; D006859:Hydrogen / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D003580:Cytochromes; D008293:Malates; D006859:Hydrogen; D002746:Chlorpromazine