[Metabolism of foreign substances in human skin and hair follicles].
Human skin has an inducible aryl hydrocarbon hydroxylase (AHH) activity which is dependent on cytochrome P-450. The cutaneous AHH-activity is inhibited by 7,8 benzoflavone but not by metapyrone, whereas recently published data showed that AHH-activity in human liver is enhanced by 7,8 benzoflavone and inhibited by metapyrone. These results suggest that AHH activity of human skin depends on different isoenzymes compared with those in human liver.
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001564:Benzo(a)pyrene / Q000378:metabolism*; D001571:Benzoflavones / Q000494:pharmacology; D046508:Culture Techniques; D003577:Cytochrome P-450 Enzyme System / Q000494:pharmacology; D004790:Enzyme Induction; D004794:Enzyme Repression; D005663:Furans / Q000494:pharmacology; D006197:Hair / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008861:Microsomes / Q000201:enzymology; D011725:Pyridines / Q000494:pharmacology; D012867:Skin / Q000201:enzymology / Q000378:metabolism*
D001571:Benzoflavones; D005663:Furans; D011725:Pyridines; C013109:metapyrone; D001564:Benzo(a)pyrene; C018674:tetrahydrofuran; C011512:alpha-naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases
Fremdstoff-Metabolismus in menschlicher Haut und Haarfollikeln.