Bile acid profiles in analbuminemia rats.
Bile acid profiles in serum, urine and bile of Nagase analbuminemia rats (NAR) and Sprague-Dawley rats (SDR) were examined. Serum bile acid levels in NAR (2.02 + 0.51 micrograms/ml, n = 15, M +/- S.E.) were markedly decreased as compared with those in SDR (20.86 +/- 3.72 micrograms/ml, n = 10). The unbound fraction of acids in serum examined by equilibrium dialysis was about ten times higher in NAR than in SDR. In the profiles of urinary and biliary bile acids in NAR and SDR, as big differences as seen for serum bile acids were not observed. Low bile acid levels in serum of NAR may reflect low bile acid binding capacity of NAR serum because the absence of albumin was thought to be one of the major causes of low bile acid levels in serum of NAR.
D000375:Aging; D000818:Animals; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000097:blood / Q000378:metabolism* / Q000652:urine; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D008095:Lithocholic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*; D013656:Taurocholic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D002793:Cholic Acids; D012709:Serum Albumin; D013656:Taurocholic Acid; D008095:Lithocholic Acid; D019826:Cholic Acid