Hypercalcemia in disseminated histoplasmosis. Aggravation by vitamin D.
Hypercalcemia associated with disseminated histoplasmosis in an elderly male is described. Serum calcium levels increased during vitamin D supplementation, supporting the proposed mechanism of hypercalcemia in granulomatous diseases. Rapid clinical deterioration and death occurred shortly after administration of steroids for relative adrenal insufficiency. Vitamin D and calcium supplements may aggravate the hypercalcemia of granulomatous disease and should be avoided.
D002118:Calcium / Q000009:adverse effects / Q000097:blood; D006660:Histoplasmosis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000009:adverse effects*
D014807:Vitamin D; D002118:Calcium