Effect of nicotine on drinking and diuresis in septal lesioned rats.
Lesions of septal nuclei in rats enhance water intake and urine outflow. The effects of nicotine tartrate (2.5 mg/kg) on drinking and diuresis were investigated in normal, sham and septal lesioned rats. Nicotine administration resulted in a surprising hyperdipsia and polyuria in lesioned animals, the mean output rose from 38 +/- 1.3 ml (before treatment) to 101.6 +/- 6.1 (during treatment) and water intake increased from 74.2 +/- 1.8 ml to 129.8 +/- 6.4 ml.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects; D012686:Septal Nuclei / Q000187:drug effects*
D011950:Receptors, Cholinergic; D009538:Nicotine; D000109:Acetylcholine