Naloxone specifically blocks the linear locomotion in mice.
The effects of naloxone on mouse behavior were investigated by using a multi-dimensional behavioral analyzer. No significant changes in behavior were seen after 1, 3 and 10 mg/kg doses of naloxone. Within 15 min following the start of observation, however, naloxone significantly suppressed linear locomotion at the 30 mg/kg dose, while the same dose of naloxone did not markedly affect other behaviors such as rearing and grooming. These results suggest that naloxone specifically disrupts linear locomotion in the mouse.
D000818:Animals; D004723:Endorphins / Q000502:physiology; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*
D004723:Endorphins; D009270:Naloxone