The supersensitivity of dopaminergic neurons to apomorphine in rats following chronic haloperidol.
Supersensitivity to apomorphine's inhibitory effect on dopamine neurons was induced in Sprague-Dawley rats by chronically administering haloperidol. It is concluded that the increased sensitivity of dopamine neurons to apomorphine may be linked to its influence on autoreceptors. The possibility that autoreceptor supersensitivity could contribute to enhancement of antipsychotic therapy is discussed.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology
D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine