Effect of puromycin on sugar transport in isolated rat adipocytes.
This study was performed to determine whether puromycin effects sugar transport into isolated rat adipocytes. Time-course and kinetic studies demonstrated that puromycin competitively inhibited 3-O-methylglucose transport. The data indicate that there is an acute effect of puromycin on sugar transport via competitive inhibition that is independent of the inhibition of protein synthesis.
D019325:3-O-Methylglucose; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002250:Carbon Radioisotopes; D007700:Kinetics; D008297:Male; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D011691:Puromycin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D008757:Methylglucosides; D008759:Methylglycosides; D019325:3-O-Methylglucose; D011691:Puromycin