Methyl parathion (O-O-dimethyl O-4-nitrophenyl thiophosphate) effects on whole-body and tissue respiration in the teleost, Tilapia mossambica (Peters).
The respiratory parameters of a freshwater teleost, Tilapia mossambica Peters, were studied under sublethal intoxication of methyl parathion. The rate of oxygen consumption by whole fish and selected tissues decreased during a 48-hr time-course study. The activities of the respiratory enzymes succinate dehydrogenase, malate dehydrogenase, and cytochrome-c oxidase also decreased considerably under methyl parathion exposure in muscle, gill, liver, and brain tissues. These results suggest that methyl parathion has a profound effect on the oxidative metabolism of the fish which results in low ATP turnover, possibly due to its influence on the respiratory center of the brain.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005399:Fishes / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008743:Methyl Parathion / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010278:Parathion / Q000031:analogs & derivatives*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D008743:Methyl Parathion; D010278:Parathion; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase