[Formation of the complex of the triterpene glycoside holothurin A with cholesterol in liposomal membranes].
Interaction between holothurin A triterpene glycoside and lipid-cholesterol liposomes was studied by differential scanning microcalorimetry. Partial restoration of the peak of basic phase transition of dipalmitoyl phosphatidyl choline was shown to be related to the formation of holothurin A (in the membrane)-cholesterol complex. The data obtained are in favor of "sterol" hypothesis of the mechanism of membrane-tropic action of holothurin A.
D002151:Calorimetry; D002784:Cholesterol / Q000378:metabolism*; D006697:Holothurin / Q000031:analogs & derivatives / Q000378:metabolism*; D066298:In Vitro Techniques; D008081:Liposomes; D008563:Membrane Lipids / Q000378:metabolism*; D012503:Saponins / Q000378:metabolism*
D008081:Liposomes; D008563:Membrane Lipids; D012503:Saponins; D006697:Holothurin; C034723:holothurin A; D002784:Cholesterol
Obrazovanie kompleksa triterpenovogo glikozida goloturina A s kholesterinom v liposomal'nykh membranakh.