Plasma secretin in response to pure bile salts and endogenous bile in man.
The effect of exogenous bile salts on plasma concentrations of secretin was studied by infusion of chenodeoxycholate, cholate, glycocholate, and taurocholate into the duodenum of normal subjects. The effect of endogenous bile on plasma secretin was studied by ingestion of a liquid test meal, by reinfusion of postprandial duodenal aspirates with known contents of bile salts, and by stimulation of gallbladder contraction by cholecystokinin. Each experiment was performed in groups of seven subjects. The relative secretin-releasing potencies of glycocholate, cholate, taurocholate and chenodeoxycholate (2.25 mmol) were 1.0:1.3:1.9:3.2. Hydrochloric acid (0.5 mmol) was, on a molar basis, approximately ten times more potent than sodium cholate. The effect of taurocholate was diminished when a liquid meal was used as vehicle instead of saline. Endogenous bile did, in no circumstance, elicit release of secretin. It is concluded that although bile salts have the ability to stimulate secretin release, endogenous secretin release is of minor, if any, importance for secretin release when physiological conditions are approached.
D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000008:administration & dosage / Q000494:pharmacology*; D002635:Chenodeoxycholic Acid / Q000494:pharmacology; D019826:Cholic Acid; D002793:Cholic Acids / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D004386:Duodenum / Q000187:drug effects / Q000378:metabolism*; D004435:Eating; D005704:Gallbladder / Q000187:drug effects / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D006000:Glycocholic Acid / Q000494:pharmacology; D006801:Humans; D012633:Secretin / Q000097:blood*; D012844:Sincalide; D013656:Taurocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D012633:Secretin; D013656:Taurocholic Acid; D002927:Cimetidine; D019826:Cholic Acid; D006000:Glycocholic Acid; D012844:Sincalide