Computer analysis of intraarterially recorded blood pressure in conscious unrestrained rats.
A precise knowledge of cardiovascular activity and its pharmacological modifications in the conscious unrestrained animal requires intraarterial blood pressure recording for long periods of time. For that purpose, a technique was developed involving chronic catheterization of the rat abdominal aorta and the use of a computer system to perform the digitization of the blood pressure signal and the on-line calculation of five cardiovascular parameters. By means of duplexing, two rats (one treated and one control) can be studied simultaneously. Off-line processing is devoted to the graphic treatment and statistical analysis of the data. The effects of a single intravenous administration of dihydralazine are presented in order to show the usefulness of the technique.
D000818:Animals; D001158:Arteries / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination / Q000295:instrumentation*; D002317:Cardiovascular Agents / Q000494:pharmacology; D003201:Computers; D004078:Dihydralazine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002317:Cardiovascular Agents; D004078:Dihydralazine