Transcripts from an aberrantly re-arranged human T-cell receptor beta-chain gene.
A number of cDNA clones homologous to the human T-cell receptor beta-chain gene have been isolated from a library constructed from the human leukaemic cell line Jurkat. The nucleotide sequences of two of these clones demonstrate that Jurkat synthesizes an RNA, probably derived from an aberrantly rearranged C beta 1 gene, which cannot encode a functional beta-chain. This transcript contains a novel joining region and similar transcripts appear to be relatively abundant in several T-cell lines.
D001483:Base Sequence; D006801:Humans; D009693:Nucleic Acid Hybridization; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D011948:Receptors, Antigen, T-Cell