Influence of short-term water deprivation on antipyrine disposition.
The effects of acute (96 h) water deprivation on the disposition kinetics of antipyrine and hepatic cytochrome P-450 content were investigated in male rats. The disposition kinetics of antipyrine in rats deprived of water for 96 h was altered significantly: the total body clearance and steady-state volume of distribution decreased by 27.1 and 22.4%, respectively, as compared to control rats. There was no significant change in the disposition rate constant as a result of simultaneous changes in the volume of distribution and clearance. There was a 51.4% decrease in the hepatic cytochrome P-450 content in water-deprived rats. These results suggest that the pharmacokinetic changes observed in acute water deprivation with a model drug, antipyrine, are related to a decrease in total body water and to a reduced amount and/or activity of the hepatic microsomal oxidative enzymes.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D014868:Water Deprivation / Q000502:physiology*
D000983:Antipyrine