[Double-blind clinical study: flunarizine versus pizotifen in a single nightly dose in hemicrania patients].
In this double-blind clinical trial we compared the prophylactic efficacy of the calcium-entry blocker flunarizine (15 mg nocte) with that of pizotifen (1,5 mg nocte). In 30 patients affected by classical and common migraine. During a two months treatment both drugs showed a good efficacy. Flunarizine tended to more markedly suppress severity of pain and duration of attacks than pizotifen. Daytime drowsiness and weight gain occurred with both drugs; the first side effect was more evident in the group treated with flunarizine, the second one in the group treated with pizotifen.
D000328:Adult; D002936:Cinnarizine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005444:Flunarizine; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D010879:Piperazines / Q000627:therapeutic use*; D010918:Pizotyline / Q000009:adverse effects / Q000627:therapeutic use*; D013876:Thiophenes / Q000627:therapeutic use*
D010879:Piperazines; D013876:Thiophenes; D010918:Pizotyline; D002936:Cinnarizine; D005444:Flunarizine
Studio clinico in doppio cieco: flunarizina contro pizotifene in un'unica somministrazione serale in pazienti emicranici.