The penetration of metrizamide into the brain after routine lumbar myelography as shown by cerebral computed tomography and its effect on auditory brainstem transmission time.
Metrizamide is a widely used contrast medium with some well known adverse reactions. In a preliminary study, CT scans and brain stem evoked potentials (BAEP) were done before and 18 hours following lumbar myelography on 12 patients. A statistically significant prolongation of the BAEP was observed. Metrizamide therefore seems to be a potent substance in clinical use as indicated by its effect on BAEP. BAEP should not be done within the first few days after myelography with metrizamide.
D000368:Aged; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000187:drug effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D009192:Myelography; D011446:Prospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D008793:Metrizamide