Dopamine increases potassium efflux in the rat parotid gland by stimulating noradrenaline release from sympathetic nerve endings.
By studying 86Rb+ efflux (tracer for potassium) and labelled NA ([3H]NA) efflux from preloaded parotid glands in vitro it is suggested that dopamine stimulates potassium efflux through an indirect sympathomimetic activity--i.e. releasing noradrenaline from sympathetic nerve endings.
D000818:Animals; D001692:Biological Transport; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D009411:Nerve Endings / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010306:Parotid Gland / Q000294:innervation / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium; D013566:Sympathomimetics / Q000494:pharmacology
D011868:Radioisotopes; D013566:Sympathomimetics; D012413:Rubidium; D011188:Potassium; D004298:Dopamine; D009638:Norepinephrine