Amiodarone keratopathy and lens opacities.
Amiodarone hydrochloride is an antiarrhythmic drug which produces a keratopathy and anterior subcapsular lens opacities that are usually asymptomatic. Serial observations for eye findings were made in 21 patients on a daily dosage of 200-600 mg for periods ranging from six months to three years. Corneal deposits developed in all 21 patients and anterior lens opacities developed in 12 of 20 phakic patients. Resolving keratopathy was present in three patients for periods of at least seven to 20 months after amiodarone was discontinued.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001572:Benzofurans / Q000009:adverse effects*; D002386:Cataract / Q000139:chemically induced*; D003318:Corneal Opacity / Q000139:chemically induced*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D012306:Risk; D013610:Tachycardia / Q000188:drug therapy*
D001572:Benzofurans; D000638:Amiodarone