Association between giant cell (temporal) arteritis and HLA-Cw3.
Thirty-five Caucasian patients with giant cell (temporal) arteritis were typed for HLA class I and II antigens. A significant increase was found for A31, B40, Cw3, and DR4. HLA-Cw3 was the most frequent antigen observed (57%) and had the highest relative risk (5.65), suggesting that Cw3 may be the primary HLA risk factor for this disease. The increased occurrence of A31, B40, and DR4 is probably secondary to their association with Cw3.
D000368:Aged; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D013700:Giant Cell Arteritis / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D015236:HLA-C Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D011111:Polymyalgia Rheumatica / Q000235:genetics / Q000276:immunology; D012306:Risk; D044465:White People
D006680:HLA Antigens; D015236:HLA-C Antigens; C038653:HLA-C*03 antigen