Specific IgG subclass antibodies, IgE and IgG S-TS antibodies to wheat gluten fraction B in patients with coeliac disease.
Antibodies were measured in the sera of fifteen patients with untreated coeliac disease and twenty-eight patients with inflammatory bowel disease. Increased levels of specific IgG, IgG1, IgG2, and IgG4 antibody to wheat gluten fraction B, measured by an enzyme-linked immunosorbent assay, were shown in the coeliac disease group, but not in the inflammatory bowel disease group. No specific IgE antibody to fraction B was detected but 33% of the patients with coeliac disease had specific short-term sensitizing (anaphylactic) IgG antibody activity (IgG S-TS) to fraction B. There was no correlation between the IgG2 or IgG4 specific antibody and the presence of IgG S-TS activity.
D000328:Adult; D000918:Antibody Specificity; D002446:Celiac Disease / Q000276:immunology*; D005512:Food Hypersensitivity / Q000276:immunology; D005983:Glutens / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis* / Q000145:classification; D007074:Immunoglobulin G / Q000032:analysis* / Q000145:classification
D007074:Immunoglobulin G; D007073:Immunoglobulin E; D005983:Glutens