Altered amitriptyline kinetics in a depressed patient with porto-caval anastomosis.
A case of altered kinetics of amitriptyline in a patient with porto-caval anastomosis and liver cirrhosis who showed an unusually strong sedative response to the drug, is presented. Therapy with tricyclic antidepressants should be initiated with lower doses and adjusted by plasma level monitoring in patients with liver by-pass.
D000284:Administration, Oral; D000328:Adult; D000639:Amitriptyline / Q000008:administration & dosage / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D008297:Male; D009661:Nortriptyline / Q000097:blood; D011167:Portacaval Shunt, Surgical
D000639:Amitriptyline; D009661:Nortriptyline