Paradoxical cardiovascular response to visceral afferent stimulation in the established spontaneously hypertensive rat.
Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that the central integrated mechanisms for activating a cardiovascular state change as evoked by visceral afferents may differ in the established hypertensive rat from that of the normotensive.
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000294:innervation / Q000503:physiopathology*; D002339:Carotid Arteries / Q000503:physiopathology; D003000:Clonidine / Q000494:pharmacology; D003250:Constriction; D004195:Disease Models, Animal; D005071:Evoked Potentials; D006973:Hypertension / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013153:Splanchnic Nerves / Q000187:drug effects / Q000503:physiopathology*
D003000:Clonidine