The effect of a diuretic (hydrochlorothiazide) on tear production in humans.
The effect of an orally administered diuretic, hydrochlorothiazide, on tear production in 11 normal young human subjects (five men and six women, 18 to 35 years old) was measured in a single-masked study. Schirmer tests with topical anesthetic showed a significant (P = .02) decrease in basal aqueous tear production on days when these subjects were taking the diuretic. The average decrease was 2.1 mm of wetting in five minutes.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003261:Contact Lenses / Q000009:adverse effects; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D012636:Secretory Rate / Q000187:drug effects; D013666:Tears / Q000378:metabolism*; D014985:Xerophthalmia / Q000139:chemically induced
D006852:Hydrochlorothiazide