Glycosaminoglycans in the bronchial mucus of patients with chronic bronchitis and mucoid impaction of the bronchus.
Glycosaminoglycans were isolated from mucus of patients with chronic bronchitis and mucoid impaction of the bronchus, whose contents were approximately 56 mumoles and 80 mumoles of hexosamine per g of dry weight of mucus respectively. Electrophoretic and chemical characterization and enzymatic susceptibility demonstrated that the glycosaminoglycans in mucus from both groups of the patients contained hyaluronic acid as the main constituent, with undersulphated chondroitin as a minor component. In addition, in mucus from the patient with mucoid impaction of the bronchus chondroitin sulphate and heparan sulphate or heparan sulphate-like substance were identified.
D000328:Adult; D000368:Aged; D001982:Bronchial Diseases / Q000378:metabolism*; D001991:Bronchitis / Q000378:metabolism*; D005591:Chemical Fractionation; D002810:Chondroitinases and Chondroitin Lyases; D002850:Chromatography, Gel; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D005688:Galactosamine / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D006025:Glycosaminoglycans / Q000302:isolation & purification*; D006595:Hexosamines / Q000032:analysis; D006601:Hexoses / Q000032:analysis; D006801:Humans; D006821:Hyaluronoglucosaminidase; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000032:analysis*; D013431:Sulfates / Q000032:analysis; D014574:Uronic Acids / Q000032:analysis
D006025:Glycosaminoglycans; D006595:Hexosamines; D006601:Hexoses; D013431:Sulfates; D014574:Uronic Acids; D005688:Galactosamine; D006821:Hyaluronoglucosaminidase; D002810:Chondroitinases and Chondroitin Lyases; D005944:Glucosamine