Histamine H1 receptors and affinity analyses in human nasal mucosa in cases of nasal allergy.
An increased number (density) or sensitivity (affinity) of histamine H1 receptors could cause an increase of allergic symptoms. Using the specific H1 receptor blocker 3H-mepyramine, we have demonstrated for the first time an H1 receptor number (Bmax) and a binding affinity (Kd) in guinea pig and human nasal mucosa. H1 antihistamines inhibited that 3H-mepyramine binding sites represent H1 receptors in nasal mucosa. Bmax and Kd values were not significantly different among the nonallergic sinusitis, vasomotor rhinitis, or the nasal allergy group, suggesting that H1 receptors do not change quantitatively and qualitatively in allergic nasal mucosa. There was no significant correlation between H1 receptor number and clinical data (IgE, peripheral eosinophils, RAST). These data suggest that H1 receptor number and affinity are not main etiological and pathophysiological factors in nasal allergy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001667:Binding, Competitive; D002648:Child; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D011738:Pyrilamine / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D012223:Rhinitis, Vasomotor / Q000378:metabolism; D012852:Sinusitis / Q000378:metabolism
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011738:Pyrilamine