Role of central nervous system monoamines in cardiopulmonary effects of Althesin in rabbit and man.
The steroid induction agent, Althesin, infused intravenously in light anesthetic doses in otherwise unsedated man (84 micrograms kg-1 min-1) and rabbit (140 micrograms kg-1 min-1) causes similar autonomic and somatic effects. In the rabbit, the rise in heart rate (mainly due to central vagal blockade) and the selective depressant effects on respiratory rate are independent of CNS 5-hydroxytryptamine and noradrenaline. The rise in arterial pressure and the fall in hindlimb conductance is dependent on CNS 5-hydroxytryptamine and noradrenaline synthesizing neurons, which are probably arranged in series. These findings provide a working hypothesis for the mechanisms of action of Althesin on central cardiopulmonary controls in man.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D012701:Serotonin; D000530:Alfaxalone Alfadolone Mixture; D009638:Norepinephrine