[Fate of benzo(a)pyrene in the digestive tract. 1. Its disappearance].
In an early stage, diets with 0,1% or 0,05% of B(a)P decreased the intake and the growth of young rats (78 g) and adult rats (415 g). The stomach tissue adsorbed the B(a)P (30 micrograms/whole tissue) by a physical mechanism. Both in intestinal contents and wall, the amount of B(a)P was much higher in growing rats than in old animals; also, the faeces respectively contained 1.99 mg and 0.03 mg of B(a)P/g dry. The "digestibility" of B(a)P was of 88.7% (after 6-13 days of experiment) to 99.6% after 15-22 days. The blood serum of young rats contained 1.36 microgram de B(a)P/100 ml.
D000042:Absorption; D000375:Aging; D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004063:Digestion; D004064:Digestive System / Q000378:metabolism*; D004435:Eating / Q000187:drug effects; D005243:Feces / Q000032:analysis; D005753:Gastric Mucosa / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001564:Benzo(a)pyrene
Evolution du benzo(a)pyrène dans le tube digestif. 1. Sa disparition.