Amiodarone-induced sinoatrial block.
We observed sinoatrial block due to chronic amiodarone administration in a 5-year-old boy with primary cardiomyopathy, Wolff-Parkinson-White syndrome and supraventricular tachycardia. Reduction in the dosage of amiodarone resulted in the disappearance of the sinoatrial block and the persistence of asymptomatic sinus bradycardia.
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D001572:Benzofurans / Q000009:adverse effects*; D009202:Cardiomyopathies / Q000188:drug therapy*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012848:Sinoatrial Block / Q000139:chemically induced*
D001572:Benzofurans; D000638:Amiodarone