Cerebrospinal fluid beta-glucuronidase activities in patients with central nervous system metastases.
beta-Glucuronidase activities were determined in cerebrospinal fluid from 249 patients suffering from various neurological diseases. Reference values were established as 9-27 mU/l. Marked elevations of cerebrospinal beta-glucuronidase activities were observed in patients with bacterial and carcinomatous meningitis. Slight elevations of cerebrospinal beta-glucuronidase activities were observed in epidural and parenchymal metastases from solid tumours. Comparison was made with the determination of total protein, glucose and lactate dehydrogenase in cerebrospinal fluid. Cerebrospinal beta-glucuronidase activity appeared the most useful test in monitoring patients at risk in developing meningeal metastases from solid primary tumours.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001099:Arachnoid; D001932:Brain Neoplasms / Q000201:enzymology; D002556:Cerebrospinal Fluid Proteins / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D005966:Glucuronidase / Q000134:cerebrospinal fluid*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid; D008297:Male; D008581:Meningitis / Q000201:enzymology; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000201:enzymology / Q000556:secondary*; D010841:Pia Mater; D012016:Reference Values; D013120:Spinal Cord Neoplasms / Q000201:enzymology / Q000556:secondary
D002556:Cerebrospinal Fluid Proteins; D007770:L-Lactate Dehydrogenase; D005966:Glucuronidase; D005947:Glucose