Plasma activities of lipoprotein lipase, hepatic lipase and lecithin: cholesterol acyltransferase in patients considered for parenteral nutrition with fat emulsion.
Intralipid is a fat emulsion which is widely used for intravenous nutrition in very ill patients. In order to know more about the capacity of these patients to metabolize exogenous triglycerides, the plasma activities of lipoprotein lipase (LPL), hepatic lipase (HL) and lecithin: cholesterol acyltransferase (LCAT), the key enzymes in the metabolism of serum lipoproteins were measured by a radioisotope technique in 23 critically ill patients and 20 patients with recent major surgery. Compared with normal volunteers, the activities were significantly decreased. On the other hand, the capacity to clear intravenously given Intralipid (0.1 g/kg), expressed as fractional removal rate (K2), was retained in patients. It is suggested that the measurement of K2 could not be useful to evaluate the capacity of Intralipid administration to satisfy the metabolic needs and also that its utilization must be reevaluated in terms of potential harmful effects.
D000328:Adult; D000368:Aged; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006304:Health Status; D006801:Humans; D008049:Lipase / Q000097:blood*; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D002785:Sterol O-Acyltransferase / Q000097:blood*
D005217:Fat Emulsions, Intravenous; D008055:Lipids; D002785:Sterol O-Acyltransferase; D008049:Lipase; D008071:Lipoprotein Lipase