Investigation of drug absorption from the gastrointestinal tract of man. IV. Influence of food and digestive secretions on metoprolol jejunal absorption.
The influence of nutrients and digestive secretions on the intestinal absorption and bioavailability of the beta-adrenoceptor antagonist, metoprolol, was investigated in an isolated segment of jejunum using an intestinal perfusion technique. Two solutions containing metoprolol, one with, and one without nutrients, were perfused into the jejunum with an occluding balloon inflated or deflated. Jejunal fluid, blood and urine samples were then collected for drug or metabolite estimation. In the segment studied, metoprolol absorption from the nutrient solution was four times that observed during perfusion of the saline solution. Bile salts did not enhance drug absorption. Both in the presence and absence of nutrients, a linear relationship was observed between the computed cumulative amount of drug absorbed from the gastrointestinal tract and the resulting plasma concentration at each sampling time, indicating that first-pass loss was not saturated. This result was also reflected in the similarity of the AUC:dose ratios, and in the lack of effect of nutrients on the metabolism of the drug.
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D001834:Body Water / Q000378:metabolism; D005502:Food; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007419:Intestinal Secretions / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008790:Metoprolol / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010648:Phenylacetates / Q000652:urine
D001647:Bile Acids and Salts; D010648:Phenylacetates; C029504:alpha-hydroxymetoprolol; C025136:phenylacetic acid; D008790:Metoprolol