Fibronectin initiates fibrin production by rabbit corneal endothelial cells in vitro.
Confluent rabbit corneal endothelial cells incubated in the absence of serum do not produce fibrinogen. When exogenous fibronectin is added to these cultures, fibrinogen production is observed. Fibronectin concentrations stimulate fibrinogen synthesis by endothelial cells in a dose-response fashion. This direct interaction of fibronectin and fibrinogen may be important in both wound healing processes and pathological states.
D000818:Animals; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D005337:Fibrin / Q000096:biosynthesis*; D005340:Fibrinogen / Q000096:biosynthesis; D005353:Fibronectins / Q000494:pharmacology*; D066298:In Vitro Techniques; D011817:Rabbits; D014945:Wound Healing
D005353:Fibronectins; D005337:Fibrin; D005340:Fibrinogen