[Quantitative evaluation and prognosis of the biological effects of hyperoxia].
Experiments in 104 white mice subjected to hyperoxia at different regimens of oxygenation, carried out by means of mathematical modelling of three hyperoxic effects (bradypnea, convulsions, lethality) revealed the dependence of biological (physiological, toxic) effects of hyperoxia upon both components of the oxygenation regimen (oxygen pressure, time of exposure). The proposed concept of integral dose allows to determine pressure-exposure correlations corresponding to a given biological phenomenon and to prognosticate the effects of hyperoxia.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D004305:Dose-Response Relationship, Drug; D006931:Hyperbaric Oxygenation; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008954:Models, Biological; D010100:Oxygen / Q000633:toxicity*; D011379:Prognosis; D013997:Time Factors
D010100:Oxygen
O kolichestvennoĭ otsenke i prognozirovanii biologicheskikh éffektov giperoksii.