Premature ovarian failure: its relationship to autoimmune disease.
Thirty-three patients with the diagnosis of chromosomally competent premature ovarian failure were reviewed for evidence of autoimmune disease. Thirty-nine percent of subjects had an associated autoimmune disorder, of which thyroid disease was the most common. One patient had vitiligo and one had adrenal insufficiency. A family history of autoimmune disease was elicited from 18% of subjects, all of whom proved to have an autoimmune disease themselves. From these findings, and a review of other studies, the authors conclude that an associated autoimmune disease, or other evidence of autoimmunity, is present in 30 to 50% of patients with premature ovarian failure.
D000293:Adolescent; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008593:Menopause; D008594:Menopause, Premature; D010049:Ovarian Diseases / Q000209:etiology* / Q000503:physiopathology; D013959:Thyroid Diseases / Q000150:complications / Q000503:physiopathology