Inhibitory influences of FMRFamide on morphine- and deprivation-induced feeding.
Intracerebroventricular administration of 0.01-1.0 microgram of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) to mice reduced morphine-induced feeding. Administration of FMRFamide also inhibited feeding induced by a 24-hour period of food deprivation. These results suggest that FMRFamide or FMRFamide-like neuropeptides play an important role in the control of opioid-mediated feeding.
D000818:Animals; D004435:Eating / Q000187:drug effects*; D019835:FMRFamide; D005508:Food Deprivation / Q000502:physiology*; D007700:Kinetics; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*
D009842:Oligopeptides; D019835:FMRFamide; D009020:Morphine