Thrombopoietin production in a patient with chronic thrombocytopenia after plasma infusion.
A thrombocytopoiesis-stimulating factor (TSF or thrombopoietin) was found to be significantly elevated in sera of a patient with chronic thrombocytopenia at one hour after infusion with fresh-frozen plasma (FFP). No detectable levels of TSF were found in the pre-infusion sera or in the infusate. At 2 hours post-infusion, TSF levels were decreased, and by 24 hrs the TSF titers were undetectable. Not only did FFP elevate TSF levels, but 6 days later significant increases in platelet counts were observed. This work confirms a previous finding of increased TSF levels following plasma infusion in a patient with similar clinical features and suggests that these patients lack a plasma factor that plays a critical role in TSF production.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D001803:Blood Transfusion; D002648:Child; D005353:Fibronectins / Q000494:pharmacology; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D051379:Mice; D013431:Sulfates / Q000097:blood; D013921:Thrombocytopenia / Q000378:metabolism*; D013926:Thrombopoietin / Q000096:biosynthesis*; D013997:Time Factors
D005353:Fibronectins; D006023:Glycoproteins; D013431:Sulfates; D013926:Thrombopoietin