5-Substituted-2,2'-anhydrouridines, potent inhibitors of uridine phosphorylase.
5-Substituted-2,2'-anhydrouridines are a new class of competitive inhibitors of uridine phosphorylase. The most potent member of the series is 2,2'-anhydro-5-ethyluridine with an apparent Ki value of 25 nM. These compounds are selective inhibitors of uridine phosphorylase and have no effect on thymidine phosphorylase. 5-Substituted-2,2'-anhydrouridines are no substrates of either uridine phosphorylase or thymidine phosphorylase.
D000818:Animals; D008297:Male; D051379:Mice; D010430:Pentosyltransferases / Q000037:antagonists & inhibitors*; D051381:Rats; D013329:Structure-Activity Relationship; D014529:Uridine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014543:Uridine Phosphorylase / Q000037:antagonists & inhibitors*
D010430:Pentosyltransferases; D014543:Uridine Phosphorylase; D014529:Uridine