Studies on high-dose chemotherapy of amygdalin in murine P388 lymphocytic leukaemia and P815 mast cell leukaemia.
The anti-tumor activity of amygdalin (NSC 251222), commercially known as Laetrile, was investigated using P388 lymphocytic leukaemia and P815 mast-cell leukaemia in BDF1 mice. Doses varying from 200 mg/kg to 2,000 mg/kg were used following the days 1 and 5 and days 1, 5 and 9 schedules. Despite treatment with high doses of amygdalin there was no prolongation in the life-span of mice bearing either P388 or P815 tumor.
D000678:Amygdalin / Q000008:administration & dosage*; D000818:Animals; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008407:Mast Cells; D051379:Mice; D008815:Mice, Inbred Strains
D000678:Amygdalin