Effects of mixed-function oxidase modifiers on neurotoxicity of acrylamide in rats.
The effects of modifiers of the microsomal mixed-function oxidase system on acrylamide-induced hind-limb paralysis were investigated in rats. Pretreatment of rats with phenobarbital, trans-stilbene oxide or dichloro diphenyl trichloroethane (DDT) resulted in an earlier onset and subsequent development of acrylamide-induced hind-limb paralysis than that observed in animals treated only with acrylamide. Cobalt chloride pretreatment of rats caused a significant delay in the onset and development of hind-limb paralysis. Our results suggest that an intermediate formed by the cytochrome P-450 system may be responsible for acrylamide neurotoxicity.
D020106:Acrylamide; D000178:Acrylamides / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D003035:Cobalt / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003634:DDT / Q000494:pharmacology; D004790:Enzyme Induction; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009420:Nervous System / Q000187:drug effects*; D010243:Paralysis / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000178:Acrylamides; D020106:Acrylamide; D003035:Cobalt; D003577:Cytochrome P-450 Enzyme System; D003634:DDT; D006899:Mixed Function Oxygenases; C018021:cobaltous chloride; D010634:Phenobarbital