Comparative toxic effect of sumithion on rat and pigeon at the level of myelin.
Both rats and pigeons treated with sumithion, an organophosphorous pesticide, at a daily oral dose of one-tenth of the LD50, die after the 6th exposure. In spinal cord myelin of pigeon cerebroside, sulphatide and total protein contents decrease by 30, 15.7 and 40.8%, respectively, and cholesterol increases by 30% after 5 days of treatment; that of the rat shows none of these changes. Densitometric scannings of sodium dodecylsulphate-polyacrylamide gels of myelin proteins show a decrease in Wolfgram and proteolipid protein in rats and in pigeons up to 3 days; after 5 days this change continues only in pigeons, whereas rats show a normal pattern. The proteolipid protein and basic protein of both the species show increased mobility towards the anode up to 3 days, whereas after 5 days this trend continues in pigeons but not in rats.
D000818:Animals; D002490:Central Nervous System / Q000032:analysis; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D002788:Cholesterol Esters / Q000032:analysis; D010856:Columbidae; D005278:Fenitrothion / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008055:Lipids / Q000032:analysis; D008297:Male; D009185:Myelin Proteins / Q000032:analysis; D009186:Myelin Sheath / Q000032:analysis*; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D013045:Species Specificity
D002788:Cholesterol Esters; D007306:Insecticides; D008055:Lipids; D009185:Myelin Proteins; D010743:Phospholipids; D005278:Fenitrothion