Ventricular tachycardia induced by clonidine withdrawal.
Ventricular tachycardia developed after the abrupt withdrawal of clonidine in a patient with atrial septal defect of the ostium secundum type, renal insufficiency, and hypertension. Ventricular tachycardia was completely suppressed by intravenous phentolamine, which contrasted with the limited effectiveness of intravenous lignocaine and procainamide. Sublingual glyceryl trinitrate or inhaled amyl nitrate reduced the blood pressure to a level similar to that after phentolamine but had no effect on the ventricular tachycardia. Ventricular tachycardia was probably produced by humoral or neural stimulation, or both, of upregulated myocardial alpha adrenoceptors.
D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D010646:Phentolamine / Q000627:therapeutic use; D011224:Prazosin / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome; D013610:Tachycardia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy
D003000:Clonidine; D011224:Prazosin; D010646:Phentolamine