Cigarette smoking causes accumulation of polymorphonuclear leukocytes in alveolar septum.
The polymorphonuclear leukocyte (PMN) may play an important role in the pathogenesis of emphysema. Cigarette smoking is associated with the accumulation of PMN in the lung as determined by bronchoalveolar lavage. We enumerated alveolar wall PMN on histologic sections from lungs of humans and hamsters with and without cigarette smoke exposure. In human nonsmokers, there were 0.9 +/- 0.2 PMN/mm alveolar wall. In cigarette smokers without emphysema, there were 2.1 +/- 0.3 PMN/mm alveolar wall (p less than 0.01), and in cigarette smokers with emphysema, there were 2.4 +/- 0.7 PMN/alveolar wall (p less than 0.05). There were 1.7 +/- 0.3 PMN/mm alveolar wall in the lungs of hamsters unexposed to cigarette smoke compared with 3.1 +/- 0.3 PMN/mm alveolar wall in smoke-exposed hamsters (p less than 0.005). Although cigarette smoking causes PMN to accumulate within alveolar septa, the accumulation does not seem to be closely related to the development of emphysema. This suggests that additional or other factors are important in the pathogenesis of emphysema.
D000368:Aged; D000818:Animals; D002452:Cell Count; D006224:Cricetinae; D006801:Humans; D008647:Mesocricetus; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D011650:Pulmonary Alveoli / Q000166:cytology*; D011656:Pulmonary Emphysema / Q000473:pathology; D012907:Smoking