Comparative study of visual evoked potentials in spinocerebellar ataxias and multiple sclerosis.
Visual evoked potentials (VEPs) were delayed in 11 out of 18 patients with Friedreich's ataxia, in 1 out of 8 patients with Strumpell's hereditary spastic ataxia, in 2 out of 5 cases with cerebellar atrophy and in 42 out of 50 patients with multiple sclerosis (MS). Responses were normal in 5 cases with Pierre Marie's disease. Amplitude and temporal dispersion were statistically analyzed in the above-mentioned groups of patients with respect to controls. An abnormal temporal dispersion, also considered as interpeak N1P2, was frequently found in MS but only occasionally in spinocerebellar ataxias. Amplitude was statistically reduced in Friedreich's ataxia group, where an inverse relationship between latency and amplitude was found. No relation was found between VEP delay and duration of the disease, in any group considered.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000175:diagnosis*; D002531:Cerebellum / Q000473:pathology; D004292:Dominance, Cerebral; D005074:Evoked Potentials, Visual; D005621:Friedreich Ataxia / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis; D011930:Reaction Time; D013118:Spinal Cord Diseases / Q000175:diagnosis*