Non-muscarinic effects of atropine on calcium conductances in cultured mouse spinal cord neurons.
Cultured neurons derived from mouse spinal cord were studied using intracellular recording techniques. Effects of muscarinic cholinergic antagonists (atropine) on voltage-dependent membrane events, which could not be related to muscarinic receptors are described. Atropine (in nanomolar to micromolar concentrations) blocks calcium conductances in a manner which is not blocked by carbachol (100 microM). A direct effect of atropine on membrane Ca2+ conductances is suggested.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D002118:Calcium / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D002478:Cells, Cultured; D004553:Electric Conductivity; D051379:Mice / Q000196:embryology; D009474:Neurons / Q000502:physiology; D011930:Reaction Time; D013116:Spinal Cord / Q000502:physiology*
D001285:Atropine; D002217:Carbachol; D002118:Calcium