Testing the statistical certainty of a response to increasing doses of a drug.
Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.
D000818:Animals; D001699:Biometry; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D012044:Regression Analysis; D012709:Serum Albumin / Q000032:analysis; D014116:Toxicology
D012709:Serum Albumin