Reactions during hemodialysis caused by allergy to ethylene oxide gas sterilization.
In patients receiving long-term hemodialysis (HD), we have examined the presence of IgE-dependent sensitization to ethylene oxide (EO) gas, which is used for sterilization of disposable medical products including dialyzers. Serum was obtained from 25 patients who experienced acute allergic reactions during HD, five patients receiving HD with isolated eosinophilia, and 37 unselected patients receiving HD. Sera from 22 of 25 of the allergic reaction group and from five of 35 of the unselected group were demonstrated to contain IgE antibodies with specificity for EO. Corresponding IgG antibodies were also present. No such antibodies were detected in serum from normal controls or ragweed-allergic patients. The serum from one patient with isolated eosinophilia had a borderline elevated IgE antibody level. These results demonstrate a close relationship between the presence of IgE antibodies to EO and HD-related allergic reactions in this patient population.
D005027:Ethylene Oxide / Q000276:immunology*; D005740:Gases; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D011852:Radioallergosorbent Test; D006435:Renal Dialysis / Q000009:adverse effects*
D005740:Gases; D005027:Ethylene Oxide