Role of thyroxine in the postnatal development of rat hepatic tryptophan oxygenase and ornithine aminotransferase.
The activities of tryptophan oxygenase and ornithine aminotransferase are known to increase markedly in rat liver during the postnatal period. The aim of this study was to determine whether thyroxine regulates the development of these two enzymes. It was found that hyperthyroidism had no effect on the activity of tryptophan oxygenase, but caused a modest increase of ornithine aminotransferase activity at 10 days of age. The latter effect persisted in adrenalectomized animals, indicating that it was not secondary to elevation of plasma corticosterone. When thyroxine was administered together with cortisone acetate, elevation of ornithine aminotransferase activity was substantially greater than that observed with cortisone acetate alone. It is concluded that the postnatal development of hepatic ornithine aminotransferase is primarily controlled by glucocorticoids, but that the effect of these hormones may be potentiated by thyroxine.
D000315:Adrenalectomy; D000818:Animals; D000833:Animals, Suckling; D003345:Corticosterone / Q000097:blood / Q000502:physiology; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D005938:Glucocorticoids / Q000502:physiology; D008099:Liver / Q000201:enzymology / Q000254:growth & development*; D009953:Ornithine-Oxo-Acid Transaminase / Q000096:biosynthesis*; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*; D000637:Transaminases / Q000096:biosynthesis*; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*
D005938:Glucocorticoids; D011441:Propylthiouracil; D014366:Tryptophan Oxygenase; D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase; D013974:Thyroxine; D003348:Cortisone; D003345:Corticosterone