Impairment of isoniazid clearance by propranolol.
The effect of propranolol on isoniazid elimination kinetics have been investigated in six healthy males. Following propranolol pretreatment of 40 mg at 8-hourly intervals given for three days, isoniazid clearance (13.0 l/hour +/- s.e.m. 2.6 l/hour) was significantly lower (p less than 0.01) than that obtained during the control study (16.4 l/hour +/- s.e.m. 3.0 l/hour). However, no significant correlation was demonstrated between the magnitude of the reduction in isoniazid clearance and the depression of the exercise-induced tachycardia caused by propranolol (rs = 0.03, p greater than 0.05). The mechanism of the impairment of isoniazid clearance by propranolol is unlikely due to the change in liver blood flow.
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D006801:Humans; D007538:Isoniazid / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*
D011433:Propranolol; D007538:Isoniazid