Kinetic profiles of diacetoxyscirpenol and two of its metabolites in blood serum of pigs.
Orally administered diacetoxyscirpenol (2 mg/kg of body weight) was rapidly absorbed into the blood serum of pigs; within 1 h, the highest amounts of diacetoxyscirpenol (9.6 to 21.9 ng/ml) were detected. Two metabolites of diacetoxyscirpenol were identified by gas chromatography-mass spectroscopy as monoacetoxyscirpenol and scirpenetriol. The three trichothecenes were present in the blood serum of pigs for only 24 h, indicating a rapid metabolism of these compounds.
D000818:Animals; D005260:Female; D008657:Metabolic Clearance Rate; D009183:Mycotoxins / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*; D013552:Swine; D014255:Trichothecenes / Q000378:metabolism*
D009183:Mycotoxins; D012717:Sesquiterpenes; D014255:Trichothecenes; C001809:diacetoxyscirpenol