The use of competitive ligand binding results in QSAR studies.
The use in QSAR studies of parameters measuring the ability of an unlabeled molecule to compete for the binding site with a radioligand is examined. It is shown that in order to employ them within a recently developed formal model it is previously necessary to carry out a linear transformation. This necessarily demands the adoption by investigators of a standard measuring procedure.
D000818:Animals; D001667:Binding, Competitive; D066298:In Vitro Techniques; D008024:Ligands; D008954:Models, Biological; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008024:Ligands; D009292:Narcotic Antagonists; D009294:Narcotics; D004364:Pharmaceutical Preparations; D011955:Receptors, Drug