Loss of responsiveness to glucagon following underperfusion of the isolated rat liver.
Increases in glucose and urea output in response to increasing glucagon concentration have been studied in isolated livers perfused with physiological concentrations of amino acids. Glucose output was more sensitive to glucagon than urea output. A period of non-perfusion caused a subsequent loss of responsiveness to glucagon concentrations, at the high end of the physiological range, but the response to glucagon at the low end of the physiological range was unaffected. This probably represents a post-receptor effect rather than alterations at the receptor level.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D005934:Glucagon / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D014508:Urea / Q000378:metabolism
D000596:Amino Acids; D014508:Urea; D005934:Glucagon; D005947:Glucose