Fluoride hypersensitivity in mains tap water demonstrated by skin potential changes in guinea-pigs.
Changes in skin electric potential following immune challenge provide a sensitive measure of the intensity of the allergic challenge. In guinea-pigs sensitised to Sodium Fluoride, Fluoridated Mains Tap Water, or Ovalbumen with Sodium Fluoride, and then challenged with one part in one million Sodium Fluoride, significant allergic responses were produced. Ovalbumen alone caused an allergic response only after a second challenge. Purified Water did not result in any immune response. It is concluded that Fluoridated Mains Tap Water is capable of causing an allergic response similar to that produced by Sodium Fluoride alone, and that Ovalbumen potentiates the immune response to Sodium Fluoride.
D000818:Animals; D000937:Antigen-Antibody Reactions; D005712:Galvanic Skin Response; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology*; D007494:Ireland; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D012969:Sodium Fluoride / Q000276:immunology*; D014881:Water Supply
D012969:Sodium Fluoride; D010047:Ovalbumin