Elimination kinetic of high polar metabolites pool of quinidine from human serum.
The elimination half-life of high polar metabolites pool of quinidine (t1/2 beta = 6.1 h) has been determined in a quinidine phenobarbiturate intoxicated patient after the complete elimination of quinidine (its precursor) from blood. It is equivalent to the generally accepted t1/2 beta of quinidine (6.1 +/- 1.8 h) but substantially different from the t1/2 beta "hybrid" of 3-hydroxyquinidine (10.0 h) determined in therapeutic conditions in which 3-hydroxyquinidine coexists with quinidine in blood. With regard to the low serum level of quinidine and strong ECG impairments, it is speculated that high polar metabolites of quinidine taken as a whole could be involved in this life threatening intoxication.
D001463:Barbiturates / Q000506:poisoning; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D011802:Quinidine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000506:poisoning; D013997:Time Factors
D001463:Barbiturates; C013569:3-hydroxyquinidine; D011802:Quinidine