An intravital microscopy model for studies of immune complex induced inflammation at the microvascular level.
The hamster cheek pouch model was used for studies of immune complex induced inflammation. Vascular leakage and leukocyte accumulation were observed after topical application of antigen. This occurred at the post-capillary venules, where also antigen localization could be seen, indicating immune complex deposition at these sites.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002610:Cheek / Q000098:blood supply; D006224:Cricetinae; D007249:Inflammation / Q000276:immunology* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D008833:Microcirculation / Q000032:analysis / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex