[Method for the cross protection of mice in studying the antigenic variability of the influenza virus].
A modification of the method of cross protection of mice was developed for the study of influenza virus antigenic drift. This modification does not require a pre-adaptation of the virus to mouse lungs. The experiments of cross protection of immune animals carried out by the modified method demonstrated antigenic variability of the influenza A virus strains (H3N2) isolated in 1968-1983. Immunologically significant differences between influenza A/Hong Kong/68/ and A/Victoria/36/72 virus strains were detected. Subsequently, with isolation of more influenza virus strains immunologically significant differences were found between A/Victoria/36/72 and A/Leningrad/42/75 (an analogue of A/Scotland/840/74) strains, A/Leningrad/42/75 and A/Leningrad/399/76 (an analogue of A/Victoria/3/75) strains. The differences between influenza A/Texas/1/77 and A/Leningrad/527/80 (an analogue of A/Bangkok/1/79), A/Leningrad/385/80 (an analogue of A/Bangkok/1/79), and A/Leningrad/50/83, (an analogue of A/Philippines/2/82) strains were not immunologically significant.
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002642:Chick Embryo; D003429:Cross Reactions; D014644:Genetic Variation; D007109:Immunity; D007114:Immunization / Q000379:methods; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology
D000956:Antigens, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Metodika perekrestnoĭ zashchity mysheĭ v izuchenii antigennoĭ izmenchivosti virusa grippa.