Adrenalectomy does not prevent the hyperprolactinemic, induced sexual behavior deficits in CDF male rats.
Inbred male CDF rats were bilaterally adrenalectomized and received either two pituitaries under each kidney capsule or were sham operated. They were tested at approximately four, seven and eight weeks after surgery. Between the first and second behavioral test, the animals received corticosterone replacement therapy. In each of the three tests, grafted animals exhibited deficits in male sexual behavior as compared to sham-grafted controls. These results suggest that, at least in CDF inbred rats, the adrenal gland is not necessary for the reduction in male sex behavior resulting from chronic hyperprolactinemia.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000502:physiology; D005837:Genitalia, Male / Q000033:anatomy & histology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000502:physiology; D011388:Prolactin / Q000097:blood* / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D003345:Corticosterone