Bromocriptine-induced removal of endoplasmic membranes from prolactinoma cells.
Adenomatous prolactin cells lose 39% of their cytoplasm volume within 7 days after the beginning of bromocriptine treatment. A simultaneous reduction of the rough-surfaced endoplasmic reticulum and the Golgi apparatus occurs. Their membranes are removed by rapid transport along the secretory pathway to the cell surface and to lysosomal destruction.
D000236:Adenoma / Q000188:drug therapy* / Q000648:ultrastructure; D001971:Bromocriptine / Q000627:therapeutic use*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure; D010911:Pituitary Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism*
D001971:Bromocriptine; D011388:Prolactin