Microbial phosphorylation of compactin (ML-236B) and related compounds.
Several fungal strains were found to convert compactin (ML-236B) to 5'-phosphocompactic acid. The product was isolated by solvent extraction and column chromatography, and identified by IR, UV, 1H NMR, 13C NMR and 31P NMR spectroscopy. Related structures (monacolin K, L and X) were also transformed to their corresponding phosphorylated analogues. The products were re-converted back to respective parental compounds by treatment with alkaline phosphatase of calf intestine.
D000469:Alkaline Phosphatase / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D000924:Anticholesteremic Agents / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000378:metabolism*; D006868:Hydrolysis; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin / Q000031:analogs & derivatives*; D009281:Naphthalenes / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats
D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; C012258:mevastatin; D008148:Lovastatin; D000469:Alkaline Phosphatase