[Osteogenesis induced by the addition of demineralized bone matrix to plaster pellets with antibiotics. Animal experiment].
The authors have previously shown the role of antibiotic loaded plaster-of-Paris pellets in the treatment of bone loss. In the present paper, a study has been made of the effects of osteogenesis of added decalcified bone matrix in powder. The experiment was made by the implantation of pellets in the muscles of rabbits. It was shown that bone induction by pellets of bone matrix was slightly lower when Rifamycin was added and was not modified by the addition of Fucidin or Gentamycin. The exudation of antibiotics was not diminished by the addition of bone matrix to plaster-of-Paris pellets. The double action, on infection and on bone induction, of composite pellets of plaster-of-Paris with antibiotics and bone matrix may lead to their use in the treatment of septic bone cavities since the pellets are absorbable.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001857:Bone Matrix / Q000033:anatomy & histology / Q000637:transplantation*; D002133:Calcium Sulfate; D005672:Fusidic Acid / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits; D012294:Rifamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012294:Rifamycins; D005672:Fusidic Acid; D002133:Calcium Sulfate
Ostéogénèse induite par l'addition de matrice osseuse déminéralisée à des billes de plâtre aux antibiotiques. Etude chez l'animal.