Vascular volume and permeability of human and murine tumors grown in athymic mice.
99mTc-labeled red blood cells have been used to measure tumor vascular volume (VV). When combined with the use of 125I-labeled bovine serum albumin [( 125I]BSA) and 131I-labeled IgGs this method also provides the rapid simultaneous determination of tumor vascular permeability (VP). Using this technique the VV and VP of a human (Clouser) and a murine tumor (SL2) grown in athymic mice were determined. The relative VV were Clouser = SL2 greater than or equal to skin greater than muscle. The relative VP of BSA and IgG were Clouser greater than SL2 = skin greater than muscle. These results may explain the differences observed in the accumulation of monoclonal antibodies in human and murine tumors grown in the athymic mouse.
D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D002199:Capillary Permeability; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply*; D013667:Technetium; D014183:Transplantation, Heterologous
D007074:Immunoglobulin G; D013667:Technetium