Genotoxicity of ptaquiloside, a bracken carcinogen, in the hepatocyte primary culture/DNA-repair test.
The genotoxicity of ptaquiloside (PT), recently isolated from bracken fern and shown to be carcinogenic, was examined by means of the hepatocyte primary culture/DNA-repair test. PT elicited clear unscheduled DNA synthesis with a dose-response effect. The result indicates that PT is a genotoxic carcinogen.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007189:Indans; D008099:Liver / Q000378:metabolism; D008297:Male; D009152:Mutagenicity Tests; D010947:Plants, Toxic / Q000032:analysis*; D051381:Rats; D011912:Rats, Inbred ACI; D012717:Sesquiterpenes; D013729:Terpenes / Q000633:toxicity*
D002273:Carcinogens; D007189:Indans; D012717:Sesquiterpenes; D013729:Terpenes; D004247:DNA; C043680:ptaquiloside