Plasma concentrations of fibrinopeptide A and fibrinopeptide B beta 15-42 in glomerulonephritis and the nephrotic syndrome.
Plasma fibrinopeptide A (FPA) and fibrinopeptide B beta 15-42 concentrations were determined by radioimmunoassay in 46 patients with glomerulonephritis and the nephrotic syndrome. An increase in plasma FPA and B beta 15-42 levels was noted in these patients; this increase was marked in the nephrotic patients. There was a positive correlation in these patients between plasma FPA and B beta 15-42 levels. The B beta 15-42/FPA ratio was significantly higher in nonnephrotic patients compared with controls. Intravascular coagulation with subsequent fibrinolysis to regulate fibrin formation may occur in patients. A positive correlation was found between plasma B beta 15-42 level and serum urea nitrogen or serum creatinine concentration, suggesting that plasma B beta 15-42 level is influenced not only by plasmin action, but also by renal dysfunction.
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis; D005344:Fibrinopeptide A / Q000032:analysis*; D005345:Fibrinopeptide B / Q000032:analysis*; D005921:Glomerulonephritis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000378:metabolism*; D010446:Peptide Fragments / Q000032:analysis*; D011863:Radioimmunoassay; D012709:Serum Albumin / Q000032:analysis
D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D012709:Serum Albumin; C033786:fibrinogen Bbeta (15-42); D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen; D002784:Cholesterol; D003404:Creatinine