[Plasmacytomas without paraproteins].
Rare plasmocytomas without paraprotein (frequency less than 1%) can present a diagnostic trap. Three observations give grounds for drawing attention to misinterpretation of symptoms and the problematic nature of the diagnosis. In one patient, a monoclonal immunoglobulin (kappa light-chains) was detectable in the bone-marrow myeloma cells (non-excretory plasmacytoma). In a further patient no paraprotein could be found in the myeloma cells (non-secretory plasmacytoma) despite repeated investigations. An additional unusual feature in a third patient was the simultaneous presence of chronic lymphocytic leukaemia; his plasmocytoma was first detected at autopsy.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology; D010954:Plasmacytoma / Q000150:complications / Q000378:metabolism*
D000911:Antibodies, Monoclonal
Plasmozytome ohne Paraprotein.