Association of second primary leukemias with the method of treatment of the first primary cancer.
A case-control study of the association between chemotherapy and/or radiotherapy for the first primary cancer and the second primary leukemia was made. All leukemia cases were collected from the cancer patients' file of the Osaka Cancer Registry which listed more than 220,000 cases during the 1965-82 period. Among the 2,765 leukemia patients, 46 had other (first) cancers. Two controls were selected from the cancer patients' file for each of the first primary cancers of 46 cases, with which they were matched in age, sex, cancer site, date of diagnosis, size of the treating hospital and survival period. Comparing the method of treatment of the first primary cancer in the cases and the controls, the proportion of patients treated by chemotherapy and/or radiotherapy was significantly higher among the cases than among the controls when the interval of the two primary cancers was 5 years or more.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors
D000970:Antineoplastic Agents