Indomethacin therapy for hypertrophic pulmonary osteoarthropathy in patients with bronchogenic carcinoma.
Hypertrophic pulmonary osteoarthropathy (HPO) is a disabling complication of lung cancer often requiring thoracotomy with vagotomy for control of pain. This condition was confirmed by scintigraphy in six consecutive patients with biopsy-proved lung cancer. All had characteristic bone and joint pain unresponsive to a variety of analgesics. Treatment with indomethacin gave dramatic relief of pain within 72 hours in all six. Consideration should be given to instituting a controlled trial to establish the efficacy of indomethacin for the treatment of HPO.
D000328:Adult; D002283:Carcinoma, Bronchogenic / Q000150:complications*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000188:drug therapy* / Q000209:etiology
D007213:Indomethacin