Antagonism of physostigmine induced lethality by a combination of scopolamine and methscopolamine.
The antagonistic effects of scopolamine, methscopolamine, and a combination of methscopolamine and scopolamine were evaluated in preventing physostigmine induced lethality in Swiss Webster mice. Low dose scopolamine was found to be highly effective in reversing high dose (3 X the LD100) physostigmine induced lethality, in contrast to methscopolamine, which was ineffective except in very high doses. A combination of scopolamine and methscopolamine was more effective than either drug alone.
D000818:Animals; D004357:Drug Synergism; D051379:Mice; D019832:N-Methylscopolamine; D010830:Physostigmine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D012601:Scopolamine / Q000494:pharmacology*; D012602:Scopolamine Derivatives / Q000494:pharmacology*
D012602:Scopolamine Derivatives; D010830:Physostigmine; D012601:Scopolamine; D019832:N-Methylscopolamine