Release of high molecular weight forms of met5-enkephalin-arg6-gly7-leu8 from rat brain.
The release of various molecular weight forms of met5-enk-arg6-gly7-leu8 (MERGL) from slices prepared from rat medulla-pons and hypothalamus was studied. The release of MERGL-IR from both medulla-pons and hypothalamic slices was elevated four- to ten-fold in response to potassium depolarization. Gel of 8 to 10 kilodalton MERGL-IR peptide(s), as well as MERGL itself, were released in response to stimulation with 50 mM K+.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D008526:Medulla Oblongata / Q000378:metabolism; D008970:Molecular Weight; D011149:Pons / Q000378:metabolism; D051381:Rats
D004744:Enkephalin, Methionine; C033453:enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-