Detection of thyroid tumour using a monoclonal 123I anti-human thyroglobulin antibody.
A monoclonal antibody to human thyroglobulin was radiolabelled with 123I NaI and shown to be a stable and biologically active reagent in vivo. When injected intravenously into 12 patients with cancer of the thyroid on thyroxine-replacement therapy, 6 of the 12 patients had localization of the labelled antibody in tumour sites. These results were compared to 131I scans done on the same patients 1 month after stopping thyroxine. The biological half-life of the antibody in the blood was influenced by the levels of circulating thyroglobulin.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000556:secondary; D000328:Adult; D000911:Antibodies, Monoclonal; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000556:secondary; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013954:Thyroglobulin / Q000276:immunology*; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D013954:Thyroglobulin