Microvascular repair following local crush and avulsion vascular injury.
A model has been developed demonstrating intimal damage resulting from a combined crush and avulsion injury to the femoral artery of the rat. Revascularization after traumatization is accomplished with microvascular anastomosis of the severed ends. Vascular patency rates at 2 and 7 days postoperatively are low (0-25%) in comparison with control groups (90-100%). A high correlation is found between patency tests performed at 20 minutes and at 2 days after blood flow re-establishment. Systemically administered heparin improves traumatized-vessel patency dramatically.
D000818:Animals; D005260:Female; D005263:Femoral Artery / Q000293:injuries*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D006406:Hematoma / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use; D008833:Microcirculation / Q000293:injuries / Q000601:surgery*; D011183:Postoperative Complications; D051381:Rats; D011919:Rats, Inbred Strains
D006493:Heparin