Retinal damage in pigmented and albino rats exposed to low levels of cyclic light following a single mydriatic treatment.
The present study demonstrated that less than three days of exposure to low levels of normally cycled ambient illumination are sufficient to cause death to photoreceptor cells in adult pigmented and albino rat. Cyclic light levels as low as 133 and 320 lux were found to destroy photoreceptor cells. A single mydriatic treatment with atropine immediately preceding the three-day exposure was sufficient to permit the effect in pigmented rats. No mydriasis was required for albino rats. When pigmented rats were reared in either 3 lux or 100 lux, it was found that these different light histories did not significantly affect the rats' subsequent susceptibility, during mydriasis, to retinal damage by cyclic illumination.
D000417:Albinism / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D008027:Light; D009184:Mydriatics / Q000494:pharmacology*; D010786:Photoreceptor Cells / Q000473:pathology / Q000528:radiation effects; D010858:Pigmentation; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000293:injuries / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors
D009184:Mydriatics; D001285:Atropine