Glycine antagonism by RU 5135.
In the spinal cord of the pentobarbitone-anaesthetised cat, microelectrophoretic RU 5135, a steroid derivative, was a potent strychnine-like glycine antagonist, having less effect on the inhibition by GABA of neuronal firing.
D000200:Action Potentials / Q000187:drug effects; D000731:Androstanes / Q000494:pharmacology*; D000818:Animals; D001378:Azasteroids / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors*; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D007395:Interneurons / Q000187:drug effects* / Q000502:physiology; D013260:Steroids, Heterocyclic / Q000494:pharmacology*; D013331:Strychnine / Q000494:pharmacology
D000731:Androstanes; D001378:Azasteroids; D018756:GABA Antagonists; D013260:Steroids, Heterocyclic; D006710:Homocysteine; C007956:homocysteic acid; D013331:Strychnine; C032061:RU 5135; D005998:Glycine; D001640:Bicuculline