Plasma protein changes in rats treated with hypolipidaemic drugs and with phthalate esters.
Treatment of rats with hypolipidaemic drugs or with the plasticizer di-2-ethyl hexyl phthalate caused significant alterations in the concentration of certain plasma proteins. Certain proteins showed dose-dependent increases, in other cases the plasma concentrations fell in treated animals. The changes were quite distinct from the changes in plasma proteins which occur during the acute-phase response to inflammatory agents. Some changes appeared specific to agents which produce peroxisome proliferation in liver, other alterations appeared associated with mild, but sustained, liver injury.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002994:Clofibrate / Q000494:pharmacology; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000494:pharmacology; D011345:Fenofibrate / Q000494:pharmacology; D006242:Haptoglobins / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007122:Immunoelectrophoresis; D008297:Male; D010795:Phthalic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001798:Blood Proteins; D006242:Haptoglobins; D000960:Hypolipidemic Agents; D010795:Phthalic Acids; C027387:di-n-hexyl phthalate; C010715:di-n-octyl phthalate; D004051:Diethylhexyl Phthalate; D002994:Clofibrate; D011345:Fenofibrate