Changes of auditory brainstem responses in electrolyte-induced myelinolysis in rats. Role of hyponatremia and hypernatremia.
Electrolyte-induced myelinolysis was produced in rats to evaluate electrophysiological derangement in the brainstem. Auditory brainstem responses (ABRs) were used to assess the brainstem function. Rats treated with hypertonic saline for 2 days had normal interpeak latencies in ABRs. Rats treated with vasopressin-induced hyponatremia alone and those with hypertonic saline after 3 days of hyponatremia had significantly prolonged interpeak latencies between waves II-III and III-IV in ABRs. These prolongations indicate electrophysiological derangement of the upper pons and mesencephalon in hyponatremic rats as well as in rats with hyponatremia followed by hypernatremic myelinolysis. In view of these data, hyponatremia may be a prerequisite for electrolyte-induced myelinolysis and electrolyte derangements such as hyponatremia, and rapidly correcting hypernatremia may be the cause of electrolyte-induced myelinolysis in rats.
D000818:Animals; D001306:Auditory Pathways / Q000503:physiopathology*; D001933:Brain Stem / Q000503:physiopathology*; D003711:Demyelinating Diseases / Q000139:chemically induced / Q000503:physiopathology*; D004594:Electrophysiology; D006955:Hypernatremia / Q000503:physiopathology*; D007010:Hyponatremia / Q000503:physiopathology*; D008636:Mesencephalon / Q000503:physiopathology; D011149:Pons / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D014667:Vasopressins / Q000494:pharmacology
D012462:Saline Solution, Hypertonic; D014667:Vasopressins