Increased frequency of the apolipoprotein E-4 isoform in male subjects with multifactorial hypercholesterolemia.
The apoE polymorphism was studied by two-dimensional gel electrophoresis in serum samples from 62 male subjects with multifactorial hypercholesterolemia and from 63 normal subjects. The apoE-4 isoform was significantly more frequent (p less than 0.02) among the hypercholesterolemic subjects than among the normocholesterolemic controls.
D000328:Adult; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D053327:Apolipoprotein E4; D001057:Apolipoproteins E