Inhibition of N-nitrosodiethylamine-induced respiratory tract carcinogenesis by piperonylbutoxide in hamsters.
The influence of pretreatment with piperonylbutoxide (PIP) on the biological effects of N-nitrosodiethylamine (DEN) in vivo in Syrian golden hamsters was investigated. PIP pretreatment significantly reduced covalent binding of N-[ethyl-1-14C]DEN to tissue macromolecules in trachea, lung, and liver, while it did not change the tissue distribution of the parent compound. In a chronic experiment, hamsters treated with PIP before each DEN injection did not develop any tumors or precancerous changes in the lungs, while 60% of the animals given DEN alone developed lung tumors with the morphology of Clara cells and endocrine cells. Tumor incidence in the trachea was also significantly reduced by PIP, but to a lesser extent than in the lungs.
D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000378:metabolism*; D010882:Piperonyl Butoxide / Q000494:pharmacology*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control
D009602:Nitrosamines; D004052:Diethylnitrosamine; D010882:Piperonyl Butoxide