[Skin vascular reactivity to noradrenaline in healthy subjects and hypertensives based on data from a method continuously recording the intensity of reflected light].
A method of investigating vascular response to noradrenaline is described, based on a continuous recording of changes in the intensity of reflected monochromatic light following rationed intracutaneous administration of vasoactive substances. The results of vascular response studies in 16 normal subjects and 92 patients with labile and stable essential lypertension are discussed. The amplitude of vasospastic response was shown to increase in proportion to the dose administered in both groups. Patients with stable essential hypertension demonstrated higher amplitude and longer duration of vasospastic response as well as a lower noradrenaline-sensitivity threshold.
D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000503:physiopathology; D008027:Light; D009638:Norepinephrine; D010991:Plethysmography / Q000379:methods; D012867:Skin / Q000098:blood supply / Q000187:drug effects*
D009638:Norepinephrine
Reaktivnost' kozhnykh sosudov k noradrenalinu u zdorovykh lits i bol'nykh gipertonicheskoĭ bolezn'iu po dannym metoda nepreryvnoĭ registratsii intensivnosti otrazhennogo sveta.