Congenital afibrinogenemia: an unusual case.
We describe a congenitally afibrinogenemic young man who experienced massive spontaneous bleeding episodes at unusual sites, including the thigh muscles, lung and brain. Each of these life-threatening episodes raised theoretical and critical practical problems. A large local hematoma was responsible for an accelerated consumption of fibrinogen, which was relieved following evacuation. It is unusual for an afibrinogenemic patient to survive a number of potentially lethal bleeding episodes.
D000328:Adult; D000347:Afibrinogenemia / Q000150:complications / Q000151:congenital*; D002543:Cerebral Hemorrhage / Q000209:etiology; D005340:Fibrinogen / Q000097:blood / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D009135:Muscular Diseases / Q000209:etiology; D011517:Prothrombin Time; D014057:Tomography, X-Ray Computed
D005340:Fibrinogen