Relationships between hypocalcaemic and anorectic effect of calcitonin in the rat.
Salmon calcitonin (sCT, 2 and 20 U/kg), porcine calcitonin (pCT, 20 and 40 U/kg) and human calcitonin (hCT, 20 and 40 U/kg) were injected subcutaneously to rats trained to eat their food during two hours each day. Food intake and serum Ca++ concentrations were determined at the end of 2h-feeding period. A long lasting anorectic effect was observed for 20 U/kg of sCT with a parallelism between hypocalcaemia and anorexia in the first 8 hours after treatment; on the contrary, rats continued to eat less than controls in the following hours when their serum Ca++ concentrations had risen to normal or even higher levels. As regards pCT and hCT, it was shown that these peptides reduced significantly meal size only for 1-2 hours when serum Ca++ levels were at their lowest levels for these peptides.
D000818:Animals; D001067:Appetite Depressants; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood*; D003864:Depression, Chemical; D004435:Eating / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D013997:Time Factors
D001067:Appetite Depressants; C028815:salmon calcitonin; D002116:Calcitonin; D002118:Calcium