Photodynamic inactivation and mutagenesis by angelicin (isopsoralen) or thiopyronin (methylene red) in wild-type and repair-deficient strains of bacteriophage T4.
Photodynamic inactivation of bacteriophage T4 particles, mediated by either angelicin or thiopyronin, is enhanced by defects in the T4 uvsW-uvsX-uvsY postreplication repair system but not by a defect in the denV pyrimidine-dimer-excision system. There was no evidence for functional interactions between the two repair systems. As observed previously with 8-methoxypsoralen, photodynamic mutagenesis with angelicin is abolished by defects in the uvsW-uvsX-uvsY system.
D004260:DNA Repair; D011564:Furocoumarins / Q000494:pharmacology*; D009154:Mutation; D011754:Pyronine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013604:T-Phages / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014966:Xanthenes / Q000494:pharmacology*
D011564:Furocoumarins; D014966:Xanthenes; C011659:angelicin; C005792:thiopyronine; D011754:Pyronine