[Comparative study of the relative bioavailabilities of two prazosin preparations in patients with essential hypertension].
The relative bioavailability of two different Prazosine preparations (Adversuten, VEB Arzneimittelwerk Dresden, GDR and Minipress, Pfizer GmbH, Karlsruhe, FRG) has been determined in 10 patients suffering from an essential hypertension by the cross-over test following a single oral application. The plasma concentrations determined on the same conditions revealed with both the preparations an almost equal blood level course. The pharmacokinetic parameters had been determined to the one-compartment system, demonstrating not any significant differences. Compared to the Minipress, the relative bioavailability of the preparation Adversuten was calculated to 102%. The discussion enters into a possible influence on the distribution parameters by alterations of the kidney function.
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000097:blood* / Q000627:therapeutic use; D011799:Quinazolines / Q000097:blood*
D011799:Quinazolines; D011224:Prazosin
Vergleichende Untersuchungen zur relativen Bioverfügbarkeit von zwei Prazosinpräparaten bei Patienten mit essentieller Hypertonie.