Antimicrobial activity of HR810 against 419 strict anaerobic bacteria.
HR810 and four other new beta-lactams were tested against 419 recent clinical anaerobic bacterial isolates. HR810 was found to have an antimicrobial spectrum most similar to that of cefotaxime, inhibiting 52.6% of Bacteroides fragilis group strains and 97.2% of all other anaerobic strains at an MIC of less than or equal to 16 micrograms/ml. Cefoxitin was found to have a narrower antimicrobial spectrum against the gram-positive anaerobic bacteria (8.4 to 10.1% less) than HR810 and cefotaxime, respectively.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D000097572:Cefpirome
D000900:Anti-Bacterial Agents; D002439:Cefotaxime; D002511:Cephalosporins; D000097572:Cefpirome