Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes.
We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 micrograms of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004147:Dioxins / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009154:Mutation; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D004147:Dioxins; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins