Oral stimulation alters digestion of intragastric oil meals in rats.
Rats were fed corn oil by gastric catheter, and plasma levels of triglycerides were measured 1-6 h later. In previous studies intragastric feeding of oil resulted in a more rapid rise in plasma triglycerides, followed by a more rapid fall, than oral feeding of the same amount of oil. In the present study administration of a small amount of oil or saccharin to the mouths of rats immediately before intragastric feeding prolonged the elevation in blood triglycerides 4 h later. This latter effect appeared only in rats having previous experience with oil paired with the taste. Oral stimulation with saccharin also increased the amount of fat remaining in the stomach 1 h after the intragastric meal. The amount of free fatty acids remaining in the stomach 1 h after intragastric feeding was not significantly influenced by oral stimulation, suggesting that lingual lipase is not responsible for the observed effects. These findings demonstrate that a taste which has been paired with fat intake can acquire the ability to influence the digestion of fat.
D000818:Animals; D004063:Digestion; D004361:Drug Tolerance; D005746:Gastric Emptying; D007441:Intubation, Gastrointestinal; D008297:Male; D009055:Mouth / Q000502:physiology*; D009821:Oils / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013268:Stimulation, Chemical; D013649:Taste / Q000502:physiology; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D009821:Oils; D014280:Triglycerides; D012965:Sodium Chloride; D012439:Saccharin