[Interrelations between quinidine distribution in the brain and myocardial arrhythmogenic readiness to aconitine and calcium chloride in postnatal ontogeny].
It has been shown in experiments on rats of different age that antiarrhythmic activity of quinidine during aconitine and calcium chloride arrhythmias is mediated not only via the cardial mechanisms but also via the central nervous system, with the importance of these mechanisms in postnatal ontogenesis being inconclusive.
D000157:Aconitine / Q000494:pharmacology*; D031841:Aconitum / Q000031:analogs & derivatives*; D000375:Aging / Q000187:drug effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002122:Calcium Chloride / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007700:Kinetics; D011802:Quinidine / Q000378:metabolism* / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D011802:Quinidine; D002122:Calcium Chloride; D000157:Aconitine
Vzaimosviaz' mezhdu raspredeleniem khinidina v mozge i aritmogennoĭ gotovnost'iu miokarda k akonitinu i kal'tsiia khloridu v postnatal'nom ontogeneze.