Biochemical differences between perilymph, cerebrospinal fluid and blood plasma in the guinea pig.
Seven selected biochemical substances were systematically analyzed in perilymph (PL), cerebrospinal fluid (CSF) and blood plasma or serum of anesthetized guinea pigs in order to compare the composition of these fluids with regard to the origin and biochemical nature of PL. Compositional differences between the fluids were expressed by PL/CSF and PL/plasma concentration ratios of the chemical components measured. Contrary to the prevailing notion, the results suggest that the specific biochemical composition of PL corresponds neither to that of CSF nor to that of a simple ultrafiltrate of blood plasma. Furthermore, except for the total protein concentration, no significant differences were found in the composition of PL between the scala tympani and scala vestibuli.
D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002555:Cerebrospinal Fluid / Q000032:analysis*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006168:Guinea Pigs; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D007761:Labyrinthine Fluids / Q000032:analysis*; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D010498:Perilymph / Q000032:analysis*; D011188:Potassium / Q000032:analysis; D011506:Proteins / Q000032:analysis; D011773:Pyruvates / Q000032:analysis; D019289:Pyruvic Acid; D012964:Sodium / Q000032:analysis
D001786:Blood Glucose; D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D007773:Lactates; D011506:Proteins; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D012964:Sodium; D007770:L-Lactate Dehydrogenase; D005947:Glucose; D011188:Potassium