The effect of diet on the metabolism of long acting theophylline.
Recently some concern has been expressed of the effect of diet on the metabolism of theophylline. This brief trial in normal healthy adults observed the effect of fasting, high fat, low fat, and liquid fat/low carbohydrate diet on the metabolism of a sustained-release theophylline preparation (Theo-Dur). On analysis of the mean theophylline level values, there were no significant differences in the theophylline levels between the diets. However, in certain individuals there were differences in the theophylline absorption rates between diets. No consistent pattern was seen.
D000328:Adult; D000704:Analysis of Variance; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D013806:Theophylline / Q000378:metabolism*
D004041:Dietary Fats; D013806:Theophylline