Serotonin receptors on pulmonary alveolar macrophages.
Pulmonary alveolar macrophages harvested from the albino mouse lung were shown to possess surface receptor sites capable of binding physiological concentrations of serotonin (5-hydroxytryptamine). These specific, high affinity binding sites showed temperature-dependent kinetics with a single order high affinity binding site for serotonin. The presence of serotonin receptors on pulmonary alveolar macrophages provides a basis for relating at least one mediator of pulmonary inflammatory processes and transport processes to effects upon the macrophage surface.
D000818:Animals; D001665:Binding Sites; D007700:Kinetics; D008264:Macrophages / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008855:Microscopy, Electron, Scanning; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D014316:Tritium
D011985:Receptors, Serotonin; D014316:Tritium; D012701:Serotonin