Nickel allergy: analysis of metal clothing objects and patch testing to metal samples.
In 22 nickel-sensitive subjects, 57 metal clothing objects were said to be not tolerated (37) or tolerated (20). They were analysed by X-ray energy dispersion in electron microscopy, and by the dimethylglyoxime spot test. The correlation between the analytical results and the statements of patients is discussed. Patch tests to nickel-plated metal samples with various thicknesses of chromium (0.25 mu to 1 mu) or gold/copper/cadmium (0.5 mu) were performed in human subjects or in guinea pigs sensitive to nickel. Surface-plating and anticorrosive techniques, as well as the results in nickel-sensitive subjects, are described and discussed. Good tolerance will not be obtained under experimental conditions if nickel in any form is a component of the object. It is to be hoped that appropriate regulations will prohibit the use of nickel in the manufacture of clothing objects.
D000293:Adolescent; D000328:Adult; D000818:Animals; D003020:Clothing / Q000009:adverse effects*; D003343:Corrosion; D003877:Dermatitis, Contact / Q000209:etiology* / Q000517:prevention & control; D004577:Electron Probe Microanalysis; D004595:Electroplating; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D010091:Oximes; D010328:Patch Tests
D010091:Oximes; C013501:dimethylglyoxime; D009532:Nickel