Long-term effects of febrile convulsion on seizure susceptibility in P77PMC rat--resistant to acoustic stimuli but susceptible to kainate-induced seizures.
A new audiogenic seizure (AGS)-susceptible strain of rats (P77PMC) was evaluated as a possible model of human febrile seizures. The long-term effects of experimental febrile seizures were observed. All 30-day-old rat pups exhibited clonic seizures during exposure to an ambient temperature of 45 +/- 0.5 degree C. The mean latency from the beginning of the hyperthermic stimulus to the onset of convulsion was 16.9 +/- 2.2 min. The rats survived this hyperthermic seizure, developed a resistance to acoustic stimulations, but were more susceptible at the age of 50 to 60 days to kainate-induced limbic seizures than controls. The results of this study imply that febrile seizures of developing P77PMC rats can change later seizure susceptibility, and there may be some correlation between febrile convulsion and temporal lobe epilepsy.
D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D005334:Fever / Q000150:complications*; D007113:Immunity, Innate; D007608:Kainic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors
D007608:Kainic Acid