The growing rabbit with a solitary, partially-obstructed kidney. Analysis of an experimental model with reference to the renal concentrating ability.
The systemic and renal effects of high partial ureteral obstruction were investigated in a new model of experimental hydronephrosis. The test group comprised 12 contralaterally nephrectomized growing male New Zealand rabbits. As compared to the pyelographic findings in 6 unilaterally nephrectomized control animals, the test group could be divided into partially obstructed but non-hydronephrotic and obstructed-hydronephrotic subgroups. Animals of all 3 groups were capable of increasing their weight during the first 2 postoperative months. The mean plasma creatinine concentration remained normal in the obstructed group and even hydronephrosis was compatible with a normal serum creatinine level. As studied during forced hypotonic expansion, the renal response to a vasopressin analogue was significantly different in all 3 animal groups. Reciprocal but less marked differences were noted in the animals' ability to retain water during this test. We conclude that in this experimental model the magnitude of the antidiuretic response is inversely related to the radiologically defined degree of obstruction.
D000818:Animals; D003894:Deamino Arginine Vasopressin; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D006869:Hydronephrosis / Q000503:physiopathology; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects; D007671:Kidney Concentrating Ability / Q000187:drug effects; D008297:Male; D009392:Nephrectomy; D009994:Osmolar Concentration; D011817:Rabbits / Q000254:growth & development*; D011859:Radiography; D014517:Ureteral Obstruction / Q000209:etiology* / Q000503:physiopathology
D003894:Deamino Arginine Vasopressin