The inhibition of norepinephrine release in nasal mucosa by acetylcholine.
Tritiated norepinephrine was incorporated into isolated dog nasal mucosa. Electrical stimulation of this mucosa induced a release of the tritiated norepinephrine. Acetylcholine inhibited this release in a dose-related manner. The inhibition is prevented by atropine. This data provides further evidence for the existence of presynaptic, inhibitory, muscarinic receptors on the sympathetic nerve terminals in nasal blood vessels.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D066298:In Vitro Techniques; D009297:Nasal Mucosa / Q000378:metabolism*; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010827:Physiology / Q000295:instrumentation; D014316:Tritium
D014316:Tritium; D000109:Acetylcholine; D009638:Norepinephrine