Effect of propane sultone pretreatment on Friend virus leukemogenesis in mice.
Propane sultone (PS) injected i.p. 24 or more hours before Friend leukemia virus increased the incidence of lymphoma in SJL/J mice and at a higher dose increased the incidence of erythroleukemia in B10SJF1 mice. PS at the same time also decreased hematopoietic stem cell clonogenicity.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002273:Carcinogens; D002472:Cell Transformation, Viral / Q000187:drug effects; D005622:Friend murine leukemia virus; D006410:Hematopoiesis / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007942:Leukemia, Experimental / Q000209:etiology* / Q000382:microbiology; D051379:Mice; D008815:Mice, Inbred Strains; D013876:Thiophenes
D002273:Carcinogens; D013876:Thiophenes; C003218:1,3-propane sultone