Effect of aspirin and indomethacin on exercise-induced changes in blood pressure and limb blood flow in normal volunteers.
To evaluate the possible role of prostaglandins in exercise-induced changes in blood pressure and limb blood flow we have compared the effects of aspirin and indomethacin in a double-blind placebo controlled study in a group of normal volunteers. Nine men undertook treadmill exercise after pretreatment with placebo, aspirin and indomethacin. Indomethacin caused a greater increase in systolic blood pressure during exercise than aspirin (p less than 0.05) and a smaller fall in diastolic pressure than either placebo or aspirin (p less than 0.02 and p less than 0.01). Compared with placebo both aspirin and indomethacin attenuated to a similar degree the increase in calf blood flow (p less than 0.05 and p less than 0.03) and the changes in forearm blood flow following exercise. These results suggest that although aspirin and indomethacin both inhibit prostaglandin production they have different effects on exercise-induced changes in blood pressure. They have, however, similar effects on limb blood flow.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005121:Extremities / Q000098:blood supply*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007866:Leg / Q000098:blood supply; D008297:Male; D005082:Physical Exertion; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
D001241:Aspirin; D007213:Indomethacin