Dietary selenium and aniline-induced methemoglobinemia in rats.
Depletion of selenium from rats for 8 weeks decreased blood glutathione peroxidase activity to 5.7% of that in selenium-supplemented (0.5 ppm selenium as Na2SeO3) rats. Aniline (60 mg/kg, i.p.) resulted in no significant difference in methemoglobin and blood reduced glutathione (GSH) levels between Se-deficient and Se-supplemented rats. A lowered aniline dose (36 mg/kg, i.p.) also resulted in no difference in methemoglobin levels. The selenium-deficient rat was able to reduce methemoglobin induced by aniline as efficiently as the selenium-sufficient rat.
D000814:Aniline Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D004032:Diet; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006461:Hemolysis / Q000187:drug effects; D008708:Methemoglobinemia / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000172:deficiency / Q000494:pharmacology*
D000814:Aniline Compounds; D005979:Glutathione Peroxidase; D012643:Selenium; C023650:aniline