Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan.
Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight. As demonstrated, the steady-state serum level of phenytoin is not affected by the age and sex of the patients or by phenobarbital used as a comedication. Thus, the main contributing factor influencing the steady-state serum concentration of phenytoin is the drug dosage. Among Chinese epileptic patients, the saturation of phenytoin metabolism occurs at the dosage of 4 mg/kg/day.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D044466:Asian People; D001835:Body Weight; D002648:Child; D004827:Epilepsy / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood*; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D012737:Sex Factors; D013624:Taiwan
D010672:Phenytoin; D010634:Phenobarbital