Inhibition of calcium uptake by capsaicin.
The effects of capsaicin on 45Ca2+ uptake were studied in cultured rat aortic smooth muscle and mouse neuroblastoma cell lines. Capsaicin (up to 300 microM) caused a dose-dependent inhibition of 45Ca2+ uptake both under resting (5 mM K+) and depolarizing (50 mM K+) conditions in both cell lines. These results provide one possible mechanism of action of capsaicin.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology*; D002460:Cell Line; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007477:Ions; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism; D051381:Rats
D007477:Ions; D002211:Capsaicin; D002118:Calcium