Hydrogen peroxide detoxication by catalase in subcellular fractions of human brain tumors and normal brain tissues.
Hydrogen peroxide detoxication by catalase was found to be significantly lower in human brain tumoral tissue as compared with normal brain tissue. As to the subcellular distribution of catalase activity, the tumoral tissue showed a decrease in the nuclear and mitochondrial fractions and an increase in the supernatants.
D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D002374:Catalase / Q000494:pharmacology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D066298:In Vitro Techniques; D008658:Inactivation, Metabolic; D013347:Subcellular Fractions / Q000378:metabolism
D006861:Hydrogen Peroxide; D002374:Catalase