Low-dose cytarabine: chromosomal findings suggesting its cytostatic as well as differentiating effect.
Chromosome analysis of bone marrow cells of two leukemic patients treated with low-dose cytarabine were performed before initiation of therapy and after a complete remission had been achieved. Results suggest that low-dose cytarabine had a mainly cytostatic effect in one patient and a more differentiating effect in the other.
D000368:Aged; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D002454:Cell Differentiation / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D003561:Cytarabine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008297:Male
D003561:Cytarabine