Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons.
A 3-choice, variable-delay, matching-to-sample procedure was used to evaluate drugs in both pigeons and monkeys while tested under nearly-identical conditions. Aniracetam (Roche 13-5057) improved accuracy of matching at all retention intervals following oral administration (12.5, 25 and 50 mg/kg) to macaque monkeys, with a maximal effect at 25 mg/kg. Aniracetam also antagonized scopolamine-induced impairment of the monkey's performance. Intramuscular administration of these same doses of aniracetam produced a similar, but not significant trend toward improved matching accuracy in pigeons.
D000818:Animals; D003071:Cognition / Q000187:drug effects*; D010856:Columbidae; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D011760:Pyrrolidinones / Q000494:pharmacology*; D012601:Scopolamine / Q000037:antagonists & inhibitors; D013045:Species Specificity
D011760:Pyrrolidinones; C036466:aniracetam; D012601:Scopolamine