Tests for dominant-lethal effects of 1,2-dibromo-3-chloropropane (DBCP) in male and female mice.
DBCP was studied for dominant-lethal effects in male and female mice and for total reproductive effects in females. In males it was administered either intraperitoneally or subcutaneously while in females it was given only by the former route. No DBCP-related response was observed in either males or females indicating its ineffectiveness in inducing chromosomal aberrations or cytotoxicity in mouse germ cells. These findings differ markedly from the observations made in rats by other investigators. Thus, the probable existence of a species difference in germ cell response to DBCP has been strengthened by the availability of the present results. It should be noted, however, that only two stocks of male mice have been studied so far for dominant-lethal and germ cell cytotoxicity effects.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D012098:Reproduction / Q000187:drug effects*; D012737:Sex Factors
C007318:1,2-dibromo-3-chloropropane; D011407:Propane