Effect of peritoneal dialysis on serum concentrations of three drugs commonly used in pediatric patients.
The use of peritoneal dialysis in young infants bears the theoretical advantage that the relative size of their peritoneal surface area is twice that of adults. The movement of drugs across the peritoneum is affected by the physiochemical properties of the drug molecules and the pathophysiologic condition of the patient. It is observed that the peritoneal dialysis clearances of phenobarbital, amikacin and cefazolin in infants were 1.07-1.33, 0.54-0.86 and 0.40-1.02 ml/min, respectively. The dosage determination in the dialysis patients receiving these drugs is discussed.
D000583:Amikacin / Q000097:blood*; D002437:Cefazolin / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008657:Metabolic Clearance Rate; D010530:Peritoneal Dialysis; D010634:Phenobarbital / Q000097:blood*
D007612:Kanamycin; D000583:Amikacin; D002437:Cefazolin; D010634:Phenobarbital