Effects of neonatal treatment with monosodium-glutamate in spontaneously hypertensive rats.
Following neonatal treatment with monosodium-glutamate (MSG), blood pressure in adult spontaneously hypertensive rats (SHR) was markedly lower than in control SHR, with only a small decrease in normotensive Wistar-Kyoto controls (WKY). In addition, in MSG-treated SHR an increase in pain-sensitivity was found and both strains showed increased water intake and reduced organ and body weights as compared to vehicle-treated rats.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D005971:Glutamates / Q000627:therapeutic use*; D006973:Hypertension / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012684:Sensory Thresholds / Q000187:drug effects; D012970:Sodium Glutamate / Q000494:pharmacology / Q000627:therapeutic use*; D013045:Species Specificity
D005971:Glutamates; D012970:Sodium Glutamate