Application of the modified one-compartment open model in pharmacokinetic investigations.
A simple method which uses a one-compartment open model to describe changes of concentration of a drug in blood plasma after rapid i.v. injection is described. Application of this method makes it possible to reduce the number of parameters which are necessary to describe experimental data.
D007275:Injections, Intravenous; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations