Chromatographic separation as selection process for prebiotic evolution and the origin of the genetic code.
A model for the evolution of a translation apparatus has been suggested where oligonucleotides in a hairpin conformation act as primordial adapters. Specifically activated amino acids are assumed to be attached to these hairpin molecules. For the specific activation, a chromatographic separation of, e.g. ala and CMP from gly and GMP can be accomplished on silica (e.g. of volcanic origin) with aqueous salt solutions. Other adsorbents like clays (kaolin, bentonite, montmorillonite), different silicates (florisil, magnesium trisilicate, calcium silicate, talc), hydroxyapatite, barium sulfate, calcium carbonate, calcium fluoride and titanoxide have been examined as model systems for the separation of nucleotides, nucleosides and amino acids on mineral surfaces. The possible role of chromatographic separation of amino acids for the formation of proteinoids, composed of selected amino acids, is also considered.
D000596:Amino Acids / Q000302:isolation & purification; D005075:Biological Evolution; D002845:Chromatography; D005815:Genetic Code; D008903:Minerals; D008957:Models, Genetic; D009705:Nucleosides / Q000302:isolation & purification; D009711:Nucleotides / Q000302:isolation & purification; D014176:Protein Biosynthesis
D000596:Amino Acids; D008903:Minerals; D009705:Nucleosides; D009711:Nucleotides