Upper tract tumours in patients with vesico-ureteral reflux and recurrent bladder tumours.
27 patients with recurrent low-grade, low-stage transitional cell carcinoma (TCC) of the bladder and uni- or bilateral vesico-ureteral reflux were followed for up to 18 years in order to study a possible higher incidence of TCC of the upper tract. None of the patients developed tumours of the upper collecting system during the follow-up period. Routine bladder instillations with Thiotepa may be one explanation of such a finding.
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013997:Time Factors; D014516:Ureteral Neoplasms / Q000556:secondary*; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy; D014718:Vesico-Ureteral Reflux / Q000150:complications*