Influence of testosterone on precocious sexual development in immature rainbow trout.
The influence of testosterone on plasma and pituitary levels of gonadotrophin (GTH) as well as on gonadal development was studied in immature rainbow trout. Among the animals receiving a testosterone-cocoa butter implant (200 micrograms) at the age of 5 months, gonadal puberty occurred 8 months later in half of the males (opposite to the controls which remained immature) and the beginning of oocyte maturation was observed in only one female. These animals were characterized by a higher pituitary GTH level. Owing to the multivariate statistical analyses made, it was possible to provide evidence for the presence of two populations with different reactions to the same steroid treatment. They also confirmed the existence of a positive testosterone feedback, in the male, leading to a precocious gonadal development. The pituitary GTH load obtained with 200 micrograms of testosterone seemed to be related to the age of first maturation. The secretion of an appropriate level of GTH resulting in the stimulation of gametogenesis required the availability of a relatively large pituitary GTH level and seemed to be possible because the animals were already in the pubertal period. The fact that the highest pituitary GTH level of the treated lot was found in the only female showing a beginning of sexual maturation suggests that testosterone may also act in females.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006062:Gonadotropins / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000032:analysis; D012487:Salmonidae / Q000502:physiology*; D012737:Sex Factors; D012741:Sexual Maturation / Q000187:drug effects*; D013737:Testis / Q000166:cytology; D013739:Testosterone / Q000494:pharmacology*; D014337:Trout / Q000502:physiology*
D006062:Gonadotropins; D013739:Testosterone