Mezlocillin concentrations in human aqueous humour after intravenous and subconjunctival administration.
27 patients received either 4 g intravenous infusion 1-3 h or 100 mg subconjunctival application of mezlocillin 1-12 h before cataract extraction. After intravenous administration the mean aqueous humour concentration of mezlocillin was 2.9 micrograms/ml after 2 h. The subconjunctival dose produced a mean aqueous humour concentration of 23 and 2.6 micrograms/ml after 3 and 12 h, respectively. These levels are above the minimum inhibitory concentration of mezlocillin for sensitive organisms.
D001082:Aqueous Humor / Q000032:analysis*; D002387:Cataract Extraction; D003228:Conjunctiva; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage / Q000032:analysis*; D013997:Time Factors
D008802:Mezlocillin