Effects of copper sulfate supplement on growth, tissue concentration, and ruminal solubilities of molybdenum and copper in sheep fed low and high molybdenum diets.
Each of four groups of six wethers were fed one of a low molybdenum, high molybdenum, low molybdenum plus copper sulfate, or high molybdenum plus copper sulfate corn silage-based diet for ad libitum intake for 221 days. Average daily gains and ratios of feed/gain were depressed for the high molybdenum diet as compared with the low molybdenum diet suggesting molybdenum toxicity in sheep fed the high molybdenum diet. This was alleviated partly by the copper sulfate supplement. The supplement also decreased solubility of both copper and molybdenum in the rumen but had no effect on copper concentration in blood plasma. Concentration of molybdenum was higher in both liver and kidney in sheep fed high-molybdenum diets as compared with low-molybdenum diets. Copper concentration was higher in kidneys of sheep fed high-molybdenum diets, but no difference was significant in liver copper between sheep fed diets high or low in molybdenum.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology*; D019327:Copper Sulfate; D005527:Food, Fortified; D008297:Male; D008982:Molybdenum / Q000008:administration & dosage / Q000378:metabolism*; D012417:Rumen / Q000378:metabolism*; D012756:Sheep / Q000502:physiology*; D012995:Solubility; D014018:Tissue Distribution
D003300:Copper; D008982:Molybdenum; D019327:Copper Sulfate