Vasopressin influences renal function via a spinal action.
Intrathecal injections of arginine vasopressin (AVP) (3 pmol) into the lower thoracic region in rats produced consistent, dose-dependent antidiuretic responses accompanied by elevated urine osmolality. That these responses are not due to leakage of the peptide to the periphery is suggested by (a) the lack of response to the analogue, DDAVP, and (b) the lack of antidiuretic response to intrathecal AVP in denervated kidneys.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects*; D014554:Urination / Q000187:drug effects
D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin