Unexpected increase in catecholamines in adrenals of rats treated with 3-deazaadenosine.
Using electrochemical detection, 3-deazaadenosine, a proximal inhibitor of methylation via the inhibition of S-adenosylhomocysteine hydrolase, perturbed the metabolism of catecholamines in the adrenals of rats. In adrenals of rats treated with 3-deazaadenosine, both norepinephrine and epinephrine increased significantly by about two-fold. 3-Deazaadenosine may inhibit the release of catecholamines from the adrenals by affecting membrane functions of the adrenals.
D043383:Adenosylhomocysteinase; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D006867:Hydrolases / Q000037:antagonists & inhibitors; D008745:Methylation; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012263:Ribonucleosides / Q000494:pharmacology*; D012435:S-Adenosylhomocysteine / Q000031:analogs & derivatives / Q000378:metabolism; D014372:Tubercidin / Q000494:pharmacology*
D012263:Ribonucleosides; C018258:3-deazaadenosine; C033256:S-(3-deazaadenosyl)homocysteine; D012435:S-Adenosylhomocysteine; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D014372:Tubercidin; D009638:Norepinephrine; D004837:Epinephrine