Woodchuck hepatitis virus infection: serologic and histopathologic course and outcome.
Five out of seven American woodchucks inoculated with woodchuck hepatitis virus developed antigenemia after 2 to 13 weeks followed by an antibody response. One animal became a carrier, and another animal exhibited a primary antibody response. Clinical disease was not obvious and aminotransferase elevation could not be demonstrated. Liver biopsy showed mononuclear portal infiltration and little parenchymal cell necrosis.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral / Q000032:analysis; D002353:Carrier State / Q000662:veterinary; D006518:Hepatitis Viruses / Q000276:immunology*; D006524:Hepatitis, Viral, Animal / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008392:Marmota / Q000276:immunology / Q000382:microbiology*; D009336:Necrosis; D012589:Sciuridae / Q000382:microbiology*
D000914:Antibodies, Viral; D000956:Antigens, Viral