Influence of low and high cadmium diet in normotensive and hypertensive SH-rats.
Normotensive and SH-rats (Münster strain) were fed a cadmium-rich, normal or cadmium-poor diet. The blood pressure was slightly increased in normotensive rats after feeding a cadmium-rich diet and decreased after a cadmium-poor diet. In contrast, in SH-rats blood pressure was decreased after a cadmium-rich and increased after a cadmium-poor diet. This behavior of the blood pressure corresponded with the intra-erythrocytic Ca2+ activities. Whereas the calcium activities increased in the normotensive group after a cadmium-rich diet, the calcium activities decreased in the SH-group after cadmium feeding. It should be pointed out that normally the calcium activities were found to be elevated in SH-rats. Thus, cadmium feeding here had the same effect as a calcium antagonist.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D004032:Diet; D004912:Erythrocytes / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D002104:Cadmium; D002118:Calcium