A genetic linkage study of a kindred with X-linked retinitis pigmentosa.
A large kindred with X-linked retinitis pigmentosa (XLRP) was investigated clinically and by means of genetic linkage with a view to developing methods of carrier detection and early diagnosis. A restriction fragment length polymorphism, identified by recombinant DNA probe L1.28, showed close genetic linkage to XLRP in this kindred and is a potentially useful marker for the purposes of genetic counselling.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004274:DNA, Recombinant; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010375:Pedigree; D012174:Retinitis Pigmentosa / Q000235:genetics*; D012729:Sex Chromosome Aberrations / Q000235:genetics; D014960:X Chromosome
D004274:DNA, Recombinant