Glucocorticoid-induced vasoconstriction in canine skin.
Vasoconstriction, manifest as a reduction in blood flow necessary to maintain a constant pressure, was observed over 4 h in the arteries supplying isolated abdominal skin flaps of greyhound dogs treated with intravenously administered betamethasone-17-valerate. Norepinephrine concentration-response curves performed initially and after 4 h showed no significant difference between the treated or control animals.
D000818:Animals; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D001623:Betamethasone; D001624:Betamethasone Valerate; D009638:Norepinephrine