Possible relationship of chromosome abnormalities and gene amplification with effects of chemotherapy: a neuroblastoma xenograft study.
The possible relationship of chromosome abnormalities and gene amplification with tumor growth and sensitivity to chemotherapy was studied in six human neuroblastomas transplanted in nude mice. Our results suggest that cells with DMs are more sensitive to Aclacinomycin A than those with HSRs.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics*; D004351:Drug Resistance; D005784:Gene Amplification; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009447:Neuroblastoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm