Acromegaly and bronchial carcinoid. Effect of removal of the latter.
A patient with a long-standing history of bronchial carcinoid and acromegaly was studied. There was pituitary enlargement with an intrasellar mass (brain computed tomography scan), high basal GH levels, and abnormal GH and other pituitary hormones response to oral glucose and a combined test (LHRH, TRH, insulin). After resection of the bronchial carcinoid, basal GH was normal, GH was normally suppressed during OGTT, pituitary function was within expected normal range, and there was regression of the pituitary tumor together with clinical improvement. These data suggest that the patient's acromegaly was secondary to pituitary stimulation due to the bronchial carcinoid.
D000172:Acromegaly / Q000150:complications* / Q000000981:diagnostic imaging; D002276:Carcinoid Tumor / Q000150:complications* / Q000601:surgery; D002283:Carcinoma, Bronchogenic / Q000150:complications* / Q000601:surgery; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D013006:Growth Hormone