[Effect of ubiquinone on phospholipid metabolism in radiation injury].
The synthesis and phospholipid content in the liver, intestine and spleen in normal and irradiated rats administered ubiquinone-9 were studied with the use of 3H-serine. Ubiquinone markedly activated decarboxylation of phosphatidylserine and suppressed transformation of phosphatidylethanolamine to phosphatidylcholine in rat liver and spleen. The effect was also observed in the organs of irradiated animals. In rat intestine, administration of ubiquinone normalized a sharp gamma-irradiation-induced inhibition of transformation of phosphatidylcholine from phosphatidylethanolamine. The catabolism of phospholipids under the action of ubiquinone and radiation was inhibited in the liver and, on the contrary, was activated in radiosensitive organs.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects / Q000528:radiation effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D014451:Ubiquinone / Q000627:therapeutic use*
D010743:Phospholipids; D014451:Ubiquinone; C030571:ubiquinone 9
Vliianie ubikhinona na obmen fosfolipidov pri luchevom porazhenii.