[Participation of the cholinergic nervous mechanism in regulating adequate blood supply to the rabbit cerebral cortex].
Dilatation of the pial arteries and their active segments (sphincters of the offshots and precortical arteries) was studied in rabbits under the conditions of enhanced neuronal activity of the brain cortex, induced by application of 0.5% strychnine to its surface. The blockade of the cholinergic transmission by microapplication of atropine to vessel walls caused a significant inhibition of the dilatatory responses of the study microvessels. Reduction of functional dilatation was most demonstrable in the precortical arteries, less marked in the sphincters of the offshots and still less marked in the small pial arteries. No differences in the responses of the large pial arteries were discovered either before or after atropine microapplications. The author suggests that the cholinergic mechanism plays an important part in regulation of adequate brain blood supply and that such a regulation may be performed locally within the area of a single radial artery occupying ca. 1/5 mm2 of the brain surface in rabbits.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000187:drug effects; D005260:Female; D008297:Male; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013331:Strychnine / Q000494:pharmacology; D014664:Vasodilation
D001285:Atropine; D013331:Strychnine
Uchastie kholinergicheskogo nervnogo mekhanizma v regulirovanii adekvatnogo krovosnabzheniia kory golovnogo mozga krolika.