Effect of acetazolamide (Diamox) on tear secretion.
The side effects of acetazolamide (Diamox) on lacrimation were measured in rats by means of the cotton-thread tear test. After a daily oral 1-mg dose (administered for five days), comparable to the dose used for adult humans on a drug-to-bodyweight basis, tear production remained unaffected but the lacrimal peroxidase secretion decreased by 60% of the baseline level. After withdrawal of acetazolamide the peroxidase secretion returned to the baseline level.
D000086:Acetazolamide / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D004232:Diuretics / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013666:Tears / Q000378:metabolism*
D004232:Diuretics; D000086:Acetazolamide