Lack of influence of aluminum hydroxide on the bioavailability and beta-adrenoceptor blocking activity of propranolol.
Plasma concentrations of propranolol and the changes of exercise induced heart rate were determined in 6 healthy subjects. An amount of 40 mg of propranolol was given alone or in combination with 30 ml of aluminum hydroxide gel. Neither the bioavailability nor the beta-adrenoceptor blocking activity of propranolol was significantly changed by concurrent administration of aluminum hydroxide gel. There is no need to increase the propranolol dose when aluminum hydroxide gel is administered concurrently.
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D001682:Biological Availability; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011433:Propranolol / Q000378:metabolism* / Q000494:pharmacology
D000536:Aluminum Hydroxide; D011433:Propranolol