Utilization of data obtained in pilot acute experiments for practical hygienic assessment of a chemical substance.
A large number of the chemical substances and preparations (compositions) that are incorporated into the national economy cannot be subjected to long-term and detailed testing for toxicity and safety. There are simple methods on the acute experimental level which can serve as a basis for working out the necessary prophylactic measures in introducing new substances into the industry. Determination of LD50 upon intragastric administration, intravenous administration (model of rapid penetration into the organism), static inhalatory treatment under saturated concentration, determination of the primary local effect of the skin and mucous membranes, together with careful observation of the behaviour of the experimental animals, signs of their intoxication and their death, as well as comparison of the physico-chemical properties of the substance and its already familiar structural analogues may serve as the ground for predicting the biological significance of the new substance even at longer terms of contact with the organism and making toxicological and hygienic assessments under concrete technological conditions.
D000208:Acute Disease; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003604:Czechoslovakia; D007928:Lethal Dose 50; D008452:Maximum Allowable Concentration; D008722:Methods; D051379:Mice; D011041:Poisoning / Q000209:etiology; D011042:Poisons / Q000633:toxicity*; D011817:Rabbits; D051381:Rats
D011042:Poisons