Treatment of central nervous system fungal infection with ketoconazole.
Two patients with fungal infection of the central nervous system (coccidioidal meningitis and cerebral histoplasmomas) were treated with ketoconazole for 30 months. Both responded to dosages substantially less than those described previously for similar infections. Neither patient experienced any significant adverse effects from the prolonged therapy.
D000368:Aged; D003047:Coccidioidomycosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006660:Histoplasmosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008297:Male; D008581:Meningitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D007654:Ketoconazole