An antiemetic is antidotal to the satiety effects of cholecystokinin.
Although cholecystokinin (CCK) has been proposed as a satiety agent, this property has been disputed by some who claim that the compound exerts its 'satiety' effects by inducing aversion. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects*
D000932:Antiemetics; D001549:Benzamides; D002766:Cholecystokinin; C100146:trimethobenzamide