Effect of prolactin on short circuit current, potential and electrical resistance across isolated frog skin.
The effect of a range of ovine prolactin doses (10(-9)-10(-6)M) on the short circuit current (Isc), potential difference (E) and electrical resistance (R) of isolated frog skin has been studied. Prolactin produced a dose dependent stimulation of Isc and generally a fall in R, although the latter was only significant after 10(-9) and 10(-6)M prolactin. The effect of prolactin on E was found to be more dependent upon the initial E (at the time of hormone addition) than on the dose of hormone. 10(-9)M prolactin, in contrast to higher doses, produced a sustained fall in R without stimulating Isc. Thus the effect of prolactin on frog skin appears to be predominantly on passive permeability at low doses, and on active ion transport at higher doses.
D000818:Animals; D001001:Anura; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D004594:Electrophysiology; D011388:Prolactin / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*; D012879:Skin Physiological Phenomena
D011388:Prolactin