Iron-containing granules in the syncytiotrophoblast of the human chorionic villi.
The syncytiotrophoblast of the human chorionic villi during earlier stages of gestation contains abundant granules derived from Golgi complexes. The granules often include very electron-dense lamellae in their interior, and X-ray microanalysis revealed the presence of iron in these lamellae. It is, therefore, supposed that iron particles absorbed into the syncytiotrophoblast are transported to Golgi complexes and integrated into these lamellae. No evidences that the granules are released from the cells by exocytosis have been proved. Thus, one possibility to their nature might be considered, that is they play a role in lysosomal storage of iron during earlier stages when the capillaries in the chorionic stroma are undeveloped and so have little ability to transport iron into the fetal circulation.
D002824:Chorionic Villi / Q000648:ultrastructure*; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004577:Electron Probe Microanalysis; D005260:Female; D005865:Gestational Age; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008854:Microscopy, Electron; D011247:Pregnancy; D014327:Trophoblasts / Q000648:ultrastructure*
D007501:Iron