Impairment to viability of neutrophils and lymphocytes by angular psoralens and UV-radiation.
The angular psoralen derivative, 4,5'-dimethylangelicin (Dm Agn), both without and with UV-radiation induces under adequate conditions a higher percentage of lethally damaged cultured human polymorphonuclear neutrophils (PMN) as compared with angelicin (Agn). In general, PMN photosensitized with Dm Agn are less resistant than similarly photosensitized lymphocytes. These results suggest that Dm Agn might be used to improve the photochemo (PUVA-)therapy of skin diseases where PMN are of pathogenic importance.
D002470:Cell Survival / Q000187:drug effects; D011564:Furocoumarins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D011701:PUVA Therapy; D010778:Photochemotherapy
D011564:Furocoumarins