Evaluation of the thrombogenicity of selected microporous oxygenator membranes.
A comparative study of the thrombogenicity of several microporous membranes was performed using an ex vivo system simulating the conditions in an artificial lung. A study of platelet adhesion and adsorbed protein layer indicated that the membranes separated into three groups. Copolyurethane membranes adsorbed very few platelets and appeared to be most compatible; microporous polypropylene and polytetrafluoroethylene membranes were intermediate in their response; silicone rubber and silicone rubber-coated paper membranes showed numerous platelet clots, often involving neutrophils and fibrin, and were the least blood compatible.
D004129:Dimethylpolysiloxanes; D008851:Micropore Filters; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D010973:Platelet Adhesiveness; D011108:Polymers; D011126:Polypropylenes; D011138:Polytetrafluoroethylene; D011140:Polyurethanes; D012826:Silicone Elastomers
D004129:Dimethylpolysiloxanes; D011108:Polymers; D011126:Polypropylenes; D011140:Polyurethanes; D012826:Silicone Elastomers; D011138:Polytetrafluoroethylene