Anaphylactoid reactions during anaesthesia. Seven years' experience of intradermal testing.
Sixty one patients who had suffered intra-operative anaphylactoid reactions were studied. Intradermal testing identified the causative agent in 84% of cases and, in 75% of these, muscle relaxants were responsible. Predisposing factors in patients sensitive to muscle relaxants were: female sex, previous allergy and atopy. The incidence of previous exposure was considerably higher than that reported in the literature. Pancuronium is suggested to be the least likely currently available agent to provoke a major anaphylactoid reaction.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000443:Alcuronium / Q000009:adverse effects; D000707:Anaphylaxis / Q000139:chemically induced*; D002648:Child; D003429:Cross Reactions; D005260:Female; D005703:Gallamine Triethiodide / Q000009:adverse effects; D006801:Humans; D006967:Hypersensitivity; D006969:Hypersensitivity, Immediate; D007428:Intradermal Tests; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*; D010197:Pancuronium / Q000009:adverse effects; D013390:Succinylcholine / Q000009:adverse effects; D014403:Tubocurarine / Q000009:adverse effects
D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine; D010197:Pancuronium; D005703:Gallamine Triethiodide; D000443:Alcuronium; D014403:Tubocurarine