Stereospecific reduction by narcotic antagonists of clonidine-induced food intake.
The present study examined the effect of opiate antagonists on clonidine-induced feeding in rabbits. The change in food intake induced by clonidine was blocked by naltrexone. The active (-)-isomer of the antagonist 5,9 alpha-diethyl-2-(3-furylmethyl)-2'-hydroxy-6,7-benzomorphan had an effect similar to naltrexone. Similar doses of the (+)-isomer were inactive, except at the highest dose used in the study. The results suggest that opiate antagonists block feeding elicited by a specific noradrenoreceptor agonist and that this inhibition is due to a direct interaction with opiate systems.
D000818:Animals; D001575:Benzomorphans / Q000494:pharmacology; D003000:Clonidine / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011817:Rabbits; D013237:Stereoisomerism
D001575:Benzomorphans; D009292:Narcotic Antagonists; C027247:MR 2266; D009271:Naltrexone; D003000:Clonidine