[Aldolase isozyme gene: on the structure and the tissue-specific expression of a muscle type aldolase gene].
A muscle-type aldolase gene known to be a tumor marker enzyme was analyzed. It was found that three different molecular species of the mRNA exist and are expressed in a tissue-specific manner. These mRNAs have identical coding and 3' noncoding sequences and differ only at the 5' end of the sequence. Genomic DNA analysis indicated that a single aldolase gene for one muscle type specifies three different mRNAs by organizing as a leader sequence a region corresponding to each distinct 5' end of the mRNA followed by a shared common structural gene in the genome.
D000818:Animals; D001483:Base Sequence; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology* / Q000235:genetics; D009132:Muscles / Q000201:enzymology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats
D007527:Isoenzymes; D012333:RNA, Messenger; D005634:Fructose-Bisphosphate Aldolase