Effect of increased levels of free fatty acids on the size of the ischaemic area.
Mongrel dogs, anaesthetized with sodium pentobarbital were artificially ventilated and prepared in order to produce a 3-min occlusion of the left descending coronary artery. High serum levels of free fatty acids (FFA) were obtained by infusion of Lipofundin (1 and 3 ml/min). A significant increase in the size of the ischemic area was found following a 3 ml/min infusion rate of Lipofundin, and in 2 out of 7 and 1 of 7 dogs ventricular extrasystoles and ventricular fibrillation respectively appeared. It is concluded that high level of FFA early after coronary occlusion can increase the size of the ischaemic area and can secondarily produce ventricular arrhythmias.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000209:etiology; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology / Q000633:toxicity; D004562:Electrocardiography; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010101:Oxygen Consumption / Q000187:drug effects; D010743:Phospholipids / Q000494:pharmacology / Q000633:toxicity*; D012709:Serum Albumin / Q000032:analysis; D013012:Sorbitol / Q000494:pharmacology / Q000633:toxicity*
D004338:Drug Combinations; D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D012709:Serum Albumin; C008288:Lipofundin; D013012:Sorbitol