[Synthesis and properties of an organophosphorous regulator of hemoglobin oxygenation].
Racemic 1-O-(epsilon-aminohexanoyl)-2,3-diphosphoglycerol (ADPG) was synthesized. The pH dependence of the 31P-NMR spectra was studied for the ADPG cyclohexylammonium salt. ADPG binding to hemoglobin and its functional activity as a regulator of human hemoglobin reversible oxygenation were assayed.
D055598:Chemical Phenomena; D002621:Chemistry; D004163:Diphosphoglyceric Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010108:Oxyhemoglobins / Q000378:metabolism*; D013237:Stereoisomerism
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D010108:Oxyhemoglobins; C045133:1-O-(6-aminohexanoyl)-2,3-diphosphoglycerol
Sintez i izuchenie svoĭstv fosfororganicheskogo reguliatora oksigenatsii gemoglobina.