Are beta-haemolytic streptococci involved in the pathogenesis of mesangial IgA-nephropathy?
In retrospect we have found that 38 of 187 patients who fulfilled the criteria of mesangial IgA-nephropathy had possible acute glomerulonephritis at the onset of their disease. We have therefore studied anti-streptococcal antibodies (ASO and ADNAseB) prospectively. Forty-three per cent of the patients had ADNAseB greater than 800 units. Thirty-one per cent of the patients studied more than once had a fourfold or greater change in their ADNAseB titre. Thirty-three per cent of the patients had different groups of beta-haemolytic streptococci isolated from their throats. This indicates a possible role of beta-haemolytic streptococci in the pathogenesis of some cases of mesangial IgA-nephropathy.
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D005260:Female; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D013290:Streptococcal Infections / Q000150:complications*; D013291:Streptococcus / Q000276:immunology
D000907:Antibodies, Bacterial