Changes in adenylate energy charge and total adenine nucleotide concentration in mouse testis induced by cadmium administration.
Subcutaneous administration of CdCl2 (3 mg/kg body weight) caused a decrease in adenylate energy charge, (ATP + 0.5ADP)/(ATP + ADP + AMP), and a depletion of the adenine nucleotide pool in the testis of mice. This preceded a decrease in LDH-X activity in the testicular extracts. These results biochemically support the hypothesis that the testicular damage induced by cadmium is secondary to anoxia caused by vascular lesion.
D000227:Adenine Nucleotides / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004734:Energy Metabolism / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D000227:Adenine Nucleotides; D002104:Cadmium; D000249:Adenosine Monophosphate; D007770:L-Lactate Dehydrogenase