Response of rats to seizure stimulus modified by feeding.
Wistar (W) and Sprague-Dawley (S.D.) rats responded differently to electroshock and metrazole test when fed with two diets (A and B). Latency periods of B for male (m) and female (f) were: W.m. greater than W.f. (P less than 0.001); W.m. greater than S.D.m. (P less than 0.05); S.D.f. greater than W.m. (P less than 0.001); S.D.m. B greater than S.D.m. A (P less than 0.001); W.m. B greater than W and S.D.m. A (P less than 0.001). Preconvulsive period for B were: W.f. and m. greater than S.D.f. and m. (P less than 0.001); W.m. greater than S.D.m. (P less than 0.001); W.m. greater than S.D.f. (P less than 0.001); S.D.m. greater than S.D.f. (P less than 0.001) and W.m. greater than W.f. (P less than 0.001). Effects of A were negligible. Phenytoin and phenobarbital protected against electroshock.
D000818:Animals; D004435:Eating; D004597:Electroshock; D005260:Female; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D012737:Sex Factors
D010433:Pentylenetetrazole