Pericardial haematopoiesis with tamponade in myelofibrosis.
A 52-year-old male with idiopathic myelofibrosis of 8 years' duration developed pericardial tamponade during recovery from acute tubular interstitial nephropathia following septicaemia. Splenectomy had been performed 7 yr previously. The tamponade was relieved by pericardiocentesis and its recurrence was prevented by a minor pericardiectomy. Pathological examination, including staining for factor VIII-positive cells, demonstrated extramedullary haematopoiesis in the pericardium. In patients with myelofibrosis and increased silhouette on X-ray film, with or without clinical heart failure, echocardiographic examination is recommended in order to identify a possible pericardial effusion.
D002305:Cardiac Tamponade / Q000209:etiology*; D004452:Echocardiography; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000175:diagnosis; D010496:Pericardium / Q000503:physiopathology; D055728:Primary Myelofibrosis / Q000150:complications*