Changes in fatty acid elongation in developing mouse brain by mercury--comparison with other metals.
Hg2+ dramatically altered microsomal synthesis of very long chain fatty acids specific for myelin in mouse brain, as measured by lengthening of behenyl-CoA by means of malonyl-CoA in vitro. This alteration was found with Cu2+, but not with various other metal ions, showing that changes in fatty acid synthesis could be due to the alteration of sulphydryl groups.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry / Q000187:drug effects*; D005227:Fatty Acids / Q000096:biosynthesis*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008630:Mercury Poisoning / Q000378:metabolism*; D008670:Metals / Q000506:poisoning*; D051379:Mice; D008810:Mice, Inbred C57BL
D000214:Acyl Coenzyme A; D005227:Fatty Acids; D008670:Metals; C018002:behenyl-coenzyme A; D008316:Malonyl Coenzyme A