Sodium-salicylate in contrast with acetylsalicylic acid prevents gastric antral and intestinal ulcers produced by indomethacin in the refed rat.
Indomethacin produced true ulcers; the lesions penetrated into the muscularis mucosae of the antrum of refed rats and into the intestine of both refed and conventionally fed rats. Sodium-salicylate dose-dependently and simultaneously prevented the antral and intestinal ulcers produced by indomethacin in refed rats. Acetylsalicylic acid had no preventive effect on small intestinal ulcers and markedly increased the indomethacin induced antral ulcers.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005260:Female; D007213:Indomethacin; D007410:Intestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D011706:Pyloric Antrum; D051381:Rats; D011919:Rats, Inbred Strains; D012980:Sodium Salicylate / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014456:Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D001241:Aspirin; D012980:Sodium Salicylate; D007213:Indomethacin