Pharmacokinetics of oxfendazole in red deer (Cervus elaphus).
The pharmacokinetics of oxfendazole (OFZ) in red deer (Cervus elaphus) was examined. OFZ, administered per os at 4.53 mg kg-1, was extracted in ether from plasma and identified and concentrations estimated by high pressure liquid chromatography. Irrespective of whether the animals were fed concentrates indoors as pellets or grass while on pasture, OFZ was absorbed rapidly. Concentrations of OFZ in plasma reached maxima within 20 hours (0.83 and 1.005 mg litre-1 respectively) and were undetectable 36 hours after administration. Fenbendazole was not detected at any time in the chromatograms. Metabolism of OFZ occurred rapidly producing the sulphone metabolite. In comparison with published data for OFZ in sheep, red deer appear to metabolise OFZ and excrete OFZ sulphone at much faster rates. Consequently, anthelmintic efficacy is likely to vary from species to species.
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003670:Deer / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D006109:Poaceae; D013997:Time Factors
D000871:Anthelmintics; D001562:Benzimidazoles; C031608:oxfendazole sulfone; C011030:oxfendazole