Autoradiographic distribution of [3H]dexoxadrol (a phencyclidine-related ligand) binding sites in rat and human brain.
[3H]dexoxadrol, a dissociative anesthetic, binds with high affinity to specific sites in rat brain (membrane binding and light microscopic autoradiography). Various phencyclidine (PCP) analogues compete for [3H]dexoxadrol sites in a slightly different manner than against [3H]PCP binding sites. As for [3H]PCP binding, [3H]dexoxadrol binding sites are highly concentrated in brain regions such as the cortex and the hippocampus. However, other areas such as the hypothalamus are enriched only in [3H]dexoxadrol binding sites. This suggests that [3H]dexoxadrol binds to PCP-related sites in certain brain regions but not in others. In the human forebrain, [3H]dexoxadrol binding sites are distributed as in the rat brain and mainly found in the caudate, putamen and cortex.
D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D004148:Dioxolanes / Q000378:metabolism*; D004149:Dioxoles / Q000378:metabolism*; D006801:Humans; D008566:Membranes / Q000378:metabolism; D010622:Phencyclidine / Q000378:metabolism; D010880:Piperidines / Q000378:metabolism*; D051381:Rats
D004148:Dioxolanes; D004149:Dioxoles; D010880:Piperidines; C005840:dioxadrol; D010622:Phencyclidine; C579650:dexoxadrol