A proform of secretin with high secretin-like bioactivity.
A variant form of the heptacosapeptide amide secretin, with C-terminal -Val-Gly-Lys-Arg instead of valine amide, has been isolated from porcine upper intestinal tissue. Unexpectedly, this triacontapeptide exhibited a substantially higher bioactivity than the heptacosapeptide amide.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001681:Biological Assay; D007422:Intestines / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis; D011498:Protein Precursors / Q000302:isolation & purification*; D012633:Secretin / Q000031:analogs & derivatives / Q000302:isolation & purification*; D013329:Structure-Activity Relationship; D013552:Swine
D000596:Amino Acids; D010446:Peptide Fragments; D011498:Protein Precursors; D012633:Secretin