Intraocular penetration of systemically administered antifungal agents.
Amphotericin B, 5-flucytosine (5-FC), and ketoconazole levels were estimated in vitreous and aqueous samples taken from four patients undergoing therapeutic vitrectomy for fungal endophthalmitis. The levels of amphotericin B in the vitreous of three patients were low (.04 - .17 microgram/ml). However, 5-FC was present in a concentration of 22.2 micrograms/ml in one patient. In another case the aqueous level of ketoconazole was 0.35 microgram/ml. The vitreous in the same patient contained 0.71 microgram/ml of the drug.
D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy; D002387:Cataract Extraction / Q000009:adverse effects; D004340:Drug Contamination; D005123:Eye / Q000378:metabolism*; D005437:Flucytosine / Q000008:administration & dosage; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage; D009916:Orbital Diseases / Q000188:drug therapy; D011183:Postoperative Complications; D007507:Therapeutic Irrigation / Q000009:adverse effects
D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine; D007654:Ketoconazole