Isolation and characterization of and some observations on poisoning by bufadienolides from Cotyledon orbiculata L. var. orbiculata.
The approximate LD50 and cumulative effect of 4 bufadienolides, isolated from Cotyledon orbiculata, were determined in guinea-pigs. Two of the bufadienolides proved to be mildly cumulative. One of the mildly cumulative bufadienolides induced subacute intoxication with some signs of krimpsiekte when injected intravenously into a sheep over 13 days. In the sheep, the paralysis was accompanied by signs of malaise, such as electrocardiographic changes and ruminal stasis.
D000818:Animals; D002018:Bufanolides / Q000302:isolation & purification / Q000506:poisoning*; D006168:Guinea Pigs; D010939:Plant Poisoning / Q000662:veterinary*; D010947:Plants, Toxic; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*
D002018:Bufanolides; C038322:cotyledoside