The effects of chronic neuroleptic treatment on neurotensin-like immunoreactivity in the rat central nervous system.
The dopamine receptor antagonist fluphenazine decanoate, when administered for a total period of 10 months, produced a large increase in neurotensin-like immunoreactivity in dopamine-rich brain areas, such as the nucleus accumbens, the striatum and the frontal cortex. A smaller, non-significant increase was observed in the substantia nigra with no change in either the hypothalamus or the spinal cord. The present results provide further evidence in favour of a functional interaction between neurotensin and dopamine in the central nervous system.
D000818:Animals; D002490:Central Nervous System / Q000032:analysis / Q000187:drug effects*; D005476:Fluphenazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009496:Neurotensin / Q000032:analysis*; D010903:Pituitary Gland, Anterior / Q000032:analysis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D009496:Neurotensin; C011825:fluphenazine depot; D005476:Fluphenazine