[Harman-induced changes in the anxiolytic effect of diazepam].
It has been demonstrated in experiments on rats under conflict situation that intraperitoneal injection of harman in high doses (20 mg/kg) counteracts and, in low doses (1 mg/kg), potentiates the anxiolytic effect of diazepam. A possible mechanism of the dual effect of harman on the anxiolytic action of diazepam is discussed.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004347:Drug Interactions; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D000470:Alkaloids; D006247:Harmine; C005010:harman; D003975:Diazepam
Izmenenie garmanom anksioliticheskogo éffekta diazepama.