Addition of sorbitol to a milk substitute for veal calves. II. Effects on plasma, liver and muscle lipids.
Two homologous groups of preruminant male calves (10 control and 9 sorbitol) of the Friesian X Holstein crossbreed were used to study the effects of sorbitol on lipid metabolism. Between 1 and 8 weeks of age they received two diets (IC, IS) with high levels of protein and fat (23% of DM), and then between 8 and 19 weeks two diets (FC, FS) containing lower levels of protein and fat (21% of DM). Diets IC and FC contained no sorbitol, while in the IS and FS diets it accounted for 0.8% of DM. Blood samples were taken at 2, 3, 4, 7, 12 and 19 weeks of age and at the following times: 2 h before (T-2), and then 1/2 (T1/2), 2 (T2), 3 (T3), 5 (T5) and 7 (T7) hours after ingestion of the morning meal. At slaughter (19 weeks), samples of liver and of rectus abdominis muscle were taken from the carcasses. The addition of sorbitol to the replacer milks had no effect on plasma levels of nonesterified fatty acids or triglycerides. However at weeks 2, 7 and 12, the levels of free and esterified cholesterol decreased significantly by a mean of 60 and 15% respectively. Sorbitol intake significantly reduced muscle levels of triglycerides (6.8 mg/g of fresh tissue vs 18.6 mg/g), free cholesterol (0.41 mg/g vs 0.66) and total lipids (13.6 mg/g vs 26.1). Lipid composition of liver was not modified by sorbitol ingestion. An histological study confirmed that the diets caused no serious lesions. Generally, the results were more dispersed in the control group than in the sorbitol group.
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002417:Cattle; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D013012:Sorbitol / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D004041:Dietary Fats; D004044:Dietary Proteins; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D013012:Sorbitol; D002784:Cholesterol