The photodeactivation of hedamycin, an antitumor antibiotic of the pluramycin type.
The cytotoxicities of hedamycin and photohedamycin A as well as of kidamycin and isokidamycin were determined using HeLa cell cultures. Photohedamycin A proved to be 15 times less cytotoxic than hedamycin thus explaining the loss of biological activity observed for solutions of hedamycin left in daylight. The fact that photohedamycin A is less active than hedamycin, and isokidamycin less than kidamycin points to the important role the rings E and F play in the biological activity of hedamycin and kidamycin.
D000880:Anthraquinones; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000528:radiation effects*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006367:HeLa Cells / Q000187:drug effects; D008027:Light
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C001328:hedamycin