Topical indomethacin therapy before argon laser trabeculoplasty.
Fifty treatment sessions for 43 eyes (35 patients) receiving argon laser trabeculoplasty to one-half the angle were randomly assigned in a double-masked fashion to pretreatment with either topical indomethacin 1% or placebo. In 25 treatments intraocular pressure increased 3 mm Hg or more within four hours. Topical indomethacin pretreatment had no effect on the incidence, magnitude, or time course of this acute increase. It also did not alter the long-term effectiveness of the laser treatment (-3.8 mm Hg in the indomethacin-treated group vs -4.3 mm Hg in the placebo-treated group). The overall incidence of new peripheral anterior synechiae found on gonioscopy at one month was 32% (16 of 50 treatments). Synechiae formation was much higher in blacks (ten of 11 eyes or 91%) than in whites (five of 38 eyes or 13%). Although there was an association between acute anterior chamber inflammation after laser treatment and ultimate synechia formation (P less than .05), indomethacin pretreatment did not alter its occurrence.
D000368:Aged; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007429:Intraocular Pressure; D053685:Laser Therapy; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D044469:Racial Groups; D014129:Trabecular Meshwork / Q000601:surgery*
D007213:Indomethacin