Effect of ticlopidine on neutrophil chemotaxis in rats.
The ex vivo effect of oral administration of ticlopidine on rat neutrophil chemotaxis was evaluated. Rats received either 3 oral doses (100 mg/kg body weight) of the drug, within a period of 48 h, via a gastric tube, or the drug was administered in drinking water for 14 days at a dosage of 75 mg/kg/day. Absorption of the drug was manifested by significant inhibition of adenosine diphosphate-(ADP-)induced platelet aggregation. No impairment of neutrophil chemotaxis toward zymosan-activated serum was observed in the ticlopidine-treated animals. These results indicate that concentrations of ticlopidine that significantly inhibit platelet function in rats are without effect on neutrophil chemotaxis toward zymosan-activated serum.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003864:Depression, Chemical; D008297:Male; D009504:Neutrophils / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*; D013988:Ticlopidine; D015054:Zymosan / Q000494:pharmacology
D013876:Thiophenes; D000244:Adenosine Diphosphate; D015054:Zymosan; D013988:Ticlopidine