15(S)-15-methyl-prostaglandin F2 alpha used for induction of delivery in the case of intra-uterine fetal death.
102 pregnant women with intra-uterine fetal death after the 12th week of gestation were treated with 15(S)-15-methyl-prostaglandin F2 alpha intramuscularly with doses of 125-250 micrograms at 2-3 hourly intervals. In all cases abortion or delivery was completed within 30 hours. The average time in primigravidae was 9 hours 43 minutes, and in multigravidae 9 hours and 59 minutes. In approximately two-thirds of the patients, mild or moderate gastrointestinal side effects were recorded in spite of prophylactic treatment with Retardin or Loperamide + Diphenoxylate. The therapy was found to be effective, easy to administer and the side effects acceptable. No serious side effects were recorded.
D000028:Abortion, Induced; D000328:Adult; D002260:Carboprost / Q000008:administration & dosage* / Q000009:adverse effects; D004157:Diphenoxylate / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007273:Injections, Intramuscular; D007751:Labor, Induced; D008139:Loperamide / Q000627:therapeutic use; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*
D011461:Prostaglandins F, Synthetic; D008139:Loperamide; D004157:Diphenoxylate; D002260:Carboprost