Insulin antibodies in patients receiving penicillamine.
In a patient receiving penicillamine for treatment of rheumatoid arthritis, antibodies to insulin developed, which resulted in symptomatic hypoglycemia. When 30 additional patients receiving penicillamine were screened, another patient was discovered to have antibodies to insulin. The level of antibody fell sharply in both patients after penicillamine was discontinued. This particular immunologic reaction to penicillamine has not been reported previously.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007330:Insulin Antibodies / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
D001323:Autoantibodies; D007330:Insulin Antibodies; D010396:Penicillamine