Bone mineral loss during centre and home haemodialysis. Influence of vitamin D metabolites and serum parathyroid hormone.
Twenty-seven patients on chronic haemodialysis were investigated for a mean of 4.8 years (3.0-6.5 years). Mean bone mineral content fell constantly and similarly at a rate of three to four per cent per year in both centre (n = 14) and home (n = 13) haemodialysis patients. Mean serum values of 25(OH)D3 (normal), 24,25(OH)2D3 (decreased to half the normal level and 1,25(OH)2D3 (severely decreased and almost non-detectable) were similar in patients with a rapid bone mineral content loss (greater than 10%/3 years) and a slow bone mineral loss (less than 10%/3 years). Mean serum parathyroid hormone was markedly elevated, but significantly higher (about twice the level) in the 'rapid losers' than in the 'slow losers'; whereas the two groups did not differ with regard to mean serum concentrations of calcium, phosphate and alkaline phosphatase.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D005260:Female; D006437:Hemodialysis, Home / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects*; D014807:Vitamin D / Q000097:blood
D008903:Minerals; D010281:Parathyroid Hormone; D014807:Vitamin D