[Mechanism of the antihypoxic action of zinc compounds].
It was established in experimental normobaric and hypobaric hypoxia and hemic hypoxia induced by carbon monoxide poisoning that zinc compounds administered in a dose of 0.15 mA/kg have a marked prophylactic protective effect. The mechanism of action of zinc compounds consists in changes of oxygen transport blood function. It was shown that interaction of the hemoglobin molecule with zinc ion brings about an increase in Hb affinity for O2 (the left drive of the oxyhemoglobin dissociation curve), a reduction in cooperative interaction of hemoglobin subunits, and a relative decrease in hemoglobin affinity for carbon monoxide. The leading defence mechanism against hypoxic hypoxia is the left drive, the mechanism of defence against carbon monoxide protection consists in the lowering of the "hem-hem" cooperation and of the relative hemoglobin affinity for carbon monoxide.
D000208:Acute Disease; D000531:Altitude; D000818:Animals; D001273:Atmosphere Exposure Chambers; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications / Q000188:drug therapy; D002263:Carboxyhemoglobin / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010108:Oxyhemoglobins / Q000032:analysis; D011190:Potassium Cyanide / Q000633:toxicity; D051381:Rats; D015032:Zinc / Q000627:therapeutic use*
D010108:Oxyhemoglobins; D002263:Carboxyhemoglobin; D015032:Zinc; D011190:Potassium Cyanide
Mekhanizm protivogipoksicheskogo deĭstviia soedineniĭ tsinka.