Functions of polymorphonuclear (PMN) leukocytes of patients with lymphoproliferative diseases.
PMN leukocytes from untreated patients with multiple myeloma (MM), Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) were studied in vitro for their phagocytic and chemotactic function. Alkaline phosphatase score and the reduction of nitroblue tetrazolium (NBT) in these leukocytes were also determined. Most of the functions of PMN leukocytes from untreated patients with MM were impaired, compared to control leukocytes, while those from patients with HD and NHL were impaired only in their chemotactic response to casein and endotoxin-activated serum (EAS).
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D006689:Hodgkin Disease / Q000276:immunology; D006801:Humans; D008223:Lymphoma / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010084:Oxidation-Reduction; D010587:Phagocytosis
D009580:Nitroblue Tetrazolium; D000469:Alkaline Phosphatase