T-kininogen--the major plasma kininogen in rat adjuvant arthritis.
Total kininogen in plasma of Freund's adjuvant treated rats increased 20-fold 7 days following the injection. Analysis of the kininogens demonstrated that increases in T-kininogen was the major reason for the rise in kininogen. High molecular weight and low molecular weight kininogens showed little or no change. The increase in T-kininogen paralleled the inflammatory condition. Anti-inflammatory agents which reduced paw swelling also reduced plasma T-kininogen levels. Unidentified peaks on HPLC of kinin following plasma treatment by trypsin were shown to be oligopeptides containing T-kinin (Ile-serbradykinin). The relationship of T-kininogen to the inflammatory response is discussed.
D000818:Animals; D001168:Arthritis / Q000097:blood*; D001169:Arthritis, Experimental / Q000097:blood* / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007704:Kininogens / Q000097:blood*; D007705:Kinins / Q000097:blood; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D014357:Trypsin / Q000378:metabolism
D007704:Kininogens; D007705:Kinins; D003907:Dexamethasone; D014357:Trypsin; D007213:Indomethacin