[Changes in fructosediphosphate aldolase and glucose-6-phosphate dehydrogenase activity after irradiation of animals with an absolute lethal dose of gamma rays].
A single total-body exposure of rats to gamma-rays in an absolutely lethal dose caused significant changes in the activity of fructosodiphosphate aldolase (ALD) and glucose-6-phosphate dehydrogenase (G-6-PDH) in the brain, liver, myocardium and skeletal muscles. The activity of ALD was mainly inhibited and that of G-6-PDH increased. Thus, the initial step of glycolysis was significantly inhibited and the key reaction of the pentose phosphate pathway enhanced in the irradiated body.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism* / Q000528:radiation effects; D005720:Gamma Rays; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism* / Q000528:radiation effects; D006019:Glycolysis / Q000528:radiation effects; D008297:Male; D009249:NADP; D011833:Radiation Injuries, Experimental / Q000201:enzymology* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D009249:NADP; D005954:Glucosephosphate Dehydrogenase; D005634:Fructose-Bisphosphate Aldolase
Izmenenie aktivnosti al'dolazy fruktozodifosfata i gliukozo-6-fosfatdegidrogenazy pri obluchenii zhivotnykh gamma-luchami v absoliutno letal'noĭ doze.