Does the mouse C4-binding protein gene (C4BP) map in the H-2 region?
A previous study on the genetics of mouse C4-binding protein (C4-bp) indicated the existence of a genetic polymorphism. Two genetic variants were reported and their segregation used to determine the mapping position of the C4BP locus to the H-2D-Qa interval of the mouse H-2 system. We show here, however, that purified C4-bp does not display the previously reported polymorphism. The mapping position of C4BP in the mouse therefore remains undetermined.
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003181:Complement C4; D003169:Complement Inactivator Proteins; D005796:Genes; D008040:Genetic Linkage; D006023:Glycoproteins; D006183:H-2 Antigens / Q000235:genetics*; D007526:Isoelectric Point; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight
D002352:Carrier Proteins; D003181:Complement C4; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D006183:H-2 Antigens