Aminoglutethimide effect on circadian rhythms in urinary variables in a patient with idiopathic hyperaldosteronism.
Aminoglutethimide (AG: 750 mg/day) was administered to a patient with idiopathic hyperaldosteronism (IHA) and circadian rhythms in urinary excretion of sodium (UNaV), potassium (UKV), aldosterone (AER) and 17-OHCS were analyzed by the single cosinor method. Urine was collected every 4h for 24h on the day before and on the 1st, 3rd and 7th day of AG administration, and above variables in each sample were determined. Circadian rhythms of 14 patients with primary aldosteronism (PA) who served as controls were also analyzed. In the present case, circadian acrophases in UNaV and AER studied before AG administration occurred at 22(19) and 07(05), respectively. They were similar to those of preoperative PA-patients. Circadian acrophase in UNaV occurred earlier with AG administration and on the 7th day it was at 14(05), a value similar to that of postoperative PA-patients. Circadian mesor in AER decreased remarkably from 4.1 to 0.6 micrograms/4h with AG administration, as did circadian mesor in UKV, whereas circadian mesor and acrophase in 17-OHCS did not change. Thus, the circadian characteristics in urinary variables in the present IHA-case were pathophysiologically similar to those of PA.
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000328:Adult; D000450:Aldosterone / Q000652:urine; D000616:Aminoglutethimide / Q000494:pharmacology / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013997:Time Factors
D015065:17-Hydroxycorticosteroids; D000616:Aminoglutethimide; D000450:Aldosterone; D012964:Sodium; D011188:Potassium