Monoamine and diamine oxidative deamination in the longitudinal smooth muscle of guinea pig ileum.
The longitudinal smooth muscle of guinea pig ileum contains three different types of oxidative deaminating enzymes: monoamine oxidase types A and B, diamine oxidase and a soluble clorgyline-deprenyl-resistant benzylamine oxidase. These enzymes have different subcellular locations. The longitudinal smooth muscle of guinea pig ileum oxidatively deaminates beta-phenylethylamine at a much higher rate than benzylamine. beta-Phenylethylamine is a good substrate for monoamine oxidase type B but also for the soluble clorgyline-deprenyl-resistant benzylamine oxidase. On the other hand, benzylamine is oxidised by mitochondrial monoamine oxidase, by the clorgyline-deprenyl-resistant enzyme and by diamine oxidase.
D000818:Animals; D001595:Benzylamine Oxidase / Q000378:metabolism*; D001679:Biogenic Amines / Q000378:metabolism*; D003641:Deamination; D005260:Female; D006168:Guinea Pigs; D007082:Ileum; D066298:In Vitro Techniques; D008297:Male; D008861:Microsomes / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009130:Muscle, Smooth / Q000201:enzymology*; D013347:Subcellular Fractions / Q000201:enzymology
D001679:Biogenic Amines; D008996:Monoamine Oxidase Inhibitors; D001595:Benzylamine Oxidase; D008995:Monoamine Oxidase