Idiopathic dystonia-parkinsonism with marked diurnal fluctuation of symptoms.
Studies were performed on 5 patients with idiopathic dystonia-parkinsonism, each of whom had minor dystonic movements and parkinsonian symptoms with marked diurnal fluctuation. Levels of homovanillic acid and 5-hydroxyindoleacetic acid were not different from those in controls. Considerable improvement in dystonic movements and parkinsonian symptoms was obtained with a small dose of L-dopa, trihexyphenidyl hydrochloride, amantadine, or bromocriptine hydrochloride. Electrophysiological investigation confirmed that the dystonic movements, which became remarkably worsened on attempted movement, contributed importantly to the diurnal fluctuation of symptoms.
D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000097:blood; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000145:classification* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D014282:Trihexyphenidyl
D001971:Bromocriptine; D007980:Levodopa; D014282:Trihexyphenidyl