Ulcers of the small bowel associated with stomach-bypassing salicylates.
Ulcers of the small bowel are documented in a patient after intake of salsalate. Rapid clinical and endoscopic improvement occurred on discontinuation of administration of the drug. Endoscopic features suggested the direct effect of a tablet dissolving in the proximal part of the small bowel. To my knowledge, this is the first report of small-bowel ulcerations associated with the newer form of salicylates that bypass the stomach for their absorption.
D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000139:chemically induced*; D007421:Intestine, Small / Q000187:drug effects / Q000473:pathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000150:complications / Q000188:drug therapy; D010437:Peptic Ulcer / Q000150:complications; D012459:Salicylates / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced*
D012459:Salicylates; C014182:salicylsalicylic acid