[Clinical characteristics of the course of acute viral hepatitis B in middle-aged and aged patients].
The clinical manifestations of acute virus hepatitis B were studied and compared in 109 elderly and senile patients (group I) and in 103 young patients (group II). In all the patients, the clinical diagnosis was confirmed by HBsAg demonstration in the peripheral blood. It was established that hepatitis B ran a severe and medium-severe course in 93.5% of the group I patients. In severe hepatitis B, intoxication was marked in 44.6% of the group I and in 65.3% of the group II patients. In group I, it was more prolonged reaching on an average 21 +/- 2 days versus 13 +/- 3 days in group II. The liver increased by 4 cm and more in 27.52% of the group I patients and in 9.71% of the group II patients. In the group I patients, the liver size returned to normal by the discharge from hospital less frequently than in the group II patients whatever the disease severity. Splenomegaly was noted in 6.42% of the group I patients only with a severe hepatitis B, and in 23.3% of the group II patients. In the group I patients with a severe hepatitis B, bilirubinemia reached a maximum at the eleventh day of jaundice or later (71.4%). In 64.3% of the group II patients, the maximum was seen within the first ten days of jaundice. In the group I patients, more severe disease patterns correlated with more marked hyperfermentemia ALAT (31.7 +/- 1.59 mmol/h.l. in a severe pattern, 26.9 +/- 1.29 mmol/h.l. in a medium-severe pattern). In the group II patients, no relationship was found between the degree of hyperfermentemia and disease severity.
D000208:Acute Disease; D000367:Age Factors; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006529:Hepatomegaly / Q000175:diagnosis; D006801:Humans; D006932:Hyperbilirubinemia / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000175:diagnosis
D006514:Hepatitis B Surface Antigens
Klinicheskie osobennosti techeniia ostrogo virusnogo gepatita B u lits pozhilogo i starcheskogo vozrasta.