Multifocal recurrent periostitis responsive to colchicine.
A brother and sister with multifocal recurrent periostitis are presented. Their disease started at an early age and manifested itself as an episodic migrating arthropathy. At roentgenography, reversible solid periosteal reactions were visible along large tubular bones. Scintigraphic and histological investigations revealed a sterile osteitis and thickened periosteum, but there was no indication of a viral infection. The girl experienced spontaneous amelioration after puberty; the boy improved markedly on colchicine.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D006130:Growth Disorders / Q000139:chemically induced; D006801:Humans; D007223:Infant; D008297:Male; D010522:Periostitis / Q000188:drug therapy* / Q000235:genetics; D011241:Prednisone / Q000627:therapeutic use; D013752:Tetracycline / Q000627:therapeutic use; D013977:Tibia / Q000473:pathology
D000305:Adrenal Cortex Hormones; D013752:Tetracycline; D003078:Colchicine; D011241:Prednisone