Peripheral edema associated with trazodone: a report of ten cases.
Ten depressed patients treated with trazodone developed edema and weight gain that was promptly reversed by reduction or discontinuation of trazodone. This suggests a dose-dependent effect. None of the patients had an active medical problem that might predispose to edema formation. Summary data on all 10 cases and three case histories are presented to alert physicians to this side effect.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010879:Piperazines / Q000009:adverse effects*; D012008:Recurrence; D014196:Trazodone / Q000009:adverse effects* / Q000627:therapeutic use
D010879:Piperazines; D014196:Trazodone