[Structural changes in the gastric mucosa in experimental hyperthyroidism].
Using a structural and functional analysis experiments on rats have shown the morphological substrate of the impaired pepsin secretion in experimental hyperthyroidism. It has been established that enhancement of the proteolytic activity of gastric juice at early times of hyperthyroidism is linked with activation of biosynthetic processes in the chief gastric cells. Under the conditions of prolonged hyperthyroidism, the reduced proteolytic activity of gastric juice is caused by inhibition of both bioenergetic and biosynthetic processes in the chief cells.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000648:ultrastructure*; D006651:Histocytochemistry; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000633:toxicity; D013997:Time Factors
D013974:Thyroxine
Strukturnye izmeneniia slizistoĭ obolochki zheludka pri éksperimental'nom gipertireoze.