In vitro fertilization using cryopreserved donor semen in cases where both partners are infertile.
The incidence of pregnancy after in vitro fertilization (IVF) was studied in a group of 38 couples (55 cycles) where both partners were infertile. Cryopreserved donor semen (IVF-D) was used in all cycles. Results were compared with those in a control group of couples where the husband's semen was considered normal and only the wife was infertile. No significant differences were found between the IVF-D and control groups in the incidence of fertilization (80% versus 72%), pregnancy per cycle (33% versus 29%), and abortion (18% versus 20%), despite the considerably lower percentage of motile spermatozoa in the IVF-D group. Forty percent of patients, each treated unsuccessfully with at least 12 artificial inseminations with donor semen, became pregnant after one or two IVF-D cycles. It is concluded that IVF with frozen donor semen is a beneficial treatment for couples where both partners are infertile.
D005260:Female; D005307:Fertilization in Vitro; D005615:Freezing; D006801:Humans; D007247:Infertility, Female; D007248:Infertility, Male; D007315:Insemination, Artificial; D007316:Insemination, Artificial, Heterologous; D008297:Male; D012662:Semen Preservation; D013081:Sperm Motility