Antihemostatic and antithrombotic effects of capsaicin in comparison with aspirin and indomethacin.
Capsaicin prolonged the tail bleeding time in the conscious mice. This effect was dose-dependent and maximal effect was observed at 3 hr after the oral administration. Capsaicin was effective in preventing death caused by ADP-induced acute pulmonary thromboembolism in mice at dose of 25 mg/kg, while aspirin and indomethacin had no effect at 200 mg/kg. Capsaicin also reduced the mortality in collagen- and sodium arachidonate-induced thromboembolic death at dose of 25 and 50 mg/kg, respectively, and aspirin and indomethacin were also effective in these models but only when the dose was higher than 200 mg/kg. Capsaicin, aspirin or indomethacin could not protect mice from endotoxin shock. Capsaicin was found to suppress platelet aggregation markedly, but did not affect blood coagulation. In conclusion, capsaicin was proved to be more effective than aspirin and indomethacin in preventing the death of acute pulmonary thromboembolism, and this effect could be due to its inhibition on platelet aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010974:Platelet Aggregation / Q000187:drug effects; D013923:Thromboembolism / Q000517:prevention & control; D013927:Thrombosis / Q000517:prevention & control*
D000244:Adenosine Diphosphate; D001241:Aspirin; D002211:Capsaicin; D007213:Indomethacin