Potential role of angiotensin II in noise-induced increases in inner ear blood flow.
Guinea pigs were exposed to 120 dB white noise for 30 min and evidenced a four-fold elevation in plasma concentration of the potent vasoconstricting hormone angiotensin II (AII). Anesthetized animals received intra-arterial injections of AII at doses that approximated the endogenous levels measured following noise exposure. A marked decrease in skin blood flow was observed with a concomitant increase in cochlear blood flow as measured by laser Doppler flowmeters. Increased cochlear blood flow appeared to be secondary to the increases in systemic blood pressure induced by AII. These findings suggest that cochlear blood flow may increase during periods of intense noise exposure.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D009622:Noise; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply
D000804:Angiotensin II