[Effect of chronic alcoholic intoxication in the rat on the structural organization of the caudate nucleus in their progeny].
By means of light (Nissl and Golgi), electron microscopy, as well as using morphometry, structure of neurons and interneuronal connections of the nucleus caudatus has been studied in 21-day-old rats reproduced by chronically alcoholized parents. As demonstrated the investigations, in young rats, physically underdeveloped, there are some signs of a delayed maturation in neurons, dendrites and synapses. Certain distrophic and reparative shifts are observed in all experimental animals. The distrophic changes of neural structures in the nucleus caudatus preponderate over the reparative ones, and in the destructive course not only the neuronal body is involved, but its processes, as well. The lesions of the latter influence organization of the synaptic contacts. This is demonstrated as a sharply decreased number of synapses of the formation studied in the field of vision. The occurring disturbance in the structure of dendrites, which play an important role in the primary integration of the information received by the neuron, can cause development of certain mental disorders in children born in alcoholic families. The reparative changes in neurons and interneuronal connections revealed suppose possible reversibility of the morphological changes observed in the offspring of drunkards.
D000818:Animals; D002421:Caudate Nucleus / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D011247:Pregnancy; D051381:Rats; D013569:Synapses / Q000648:ultrastructure
Vliianie khronicheskoĭ alkogol'noĭ intoksikatsii krys na strukturnuiu organizatsiiu khvostatogo iadra ikh potomstva.