Colony formation by primitive haemopoietic progenitors in cocultures of bone marrow cells and stromal cells.
Human bone marrow contains a class of human haemopoietic progenitor cells that adhere to cultured marrow stromal cells and form colonies of blast cells. These progenitor cells are found in the non-adherent mononuclear fraction of normal human bone marrow. They are not in active cell cycle and do not express Ia-like (HLA-DR) antigens but appear to be capable of self-renewal in vitro. These properties indicate that they should be classified as members of the primitive haemopoietic progenitor cell compartment.
D001854:Bone Marrow Cells; D002448:Cell Adhesion; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D013997:Time Factors
D006918:Hydroxyurea