Effect of L-propargylglycine on metabolism of sulfur-containing amino acids in pregnant rats and their fetuses.
Cystathionine accumulated in several tissues of dams and fetuses by a single intraperitoneal administration of L-proparglyglycine to pregnant rats. Cystathionine in the liver of dams reached its maximal level at about 15 hrs after L-proparglyglycine injection (10 mg/300g), while that in the kidney and brain of dams, and in the liver, kidney, and brain of fetuses reached a maximum at about 21 hrs. The content of cystine in the liver of fetuses decreased gradually in proportion to the amount of L-proparglyglycine administered. Cystathionine gamma-lyase activity in the liver of dams and fetuses decreased to about 2-4% of that of control rats at 15 hrs after L-proparglyglycine injection, and that in the kidney and pancreas of dams to about 10-20% of that of control rats. On the other hand, cystathionine beta-synthase activity did not show significant changes from that of control rats.
D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003540:Cystathionine / Q000378:metabolism*; D003542:Cystathionine gamma-Lyase / Q000378:metabolism*; D003553:Cystine / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008190:Lyases / Q000378:metabolism*; D009928:Organ Specificity; D010179:Pancreas / Q000378:metabolism; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats
D000480:Alkynes; D003540:Cystathionine; D003553:Cystine; C009055:propargylglycine; D008190:Lyases; D003542:Cystathionine gamma-Lyase; D005998:Glycine