Copper malabsorption in coeliac disease.
Copper uptake during three hours from an oral test dose of copper sulphate solution giving three mg Cu++, close to the recommended daily dietary intake, was significantly reduced in patients with proximal intestinal disease, compared with normal subjects. Three out of ten patients had abnormal and otherwise unexplained blood counts compatible with the known haematological effects of copper deficiency and were restored to normal levels on a gluten-free diet. Copper deficiency and proximal intestinal disease should be suspected in patients with otherwise unexplained anaemia, especially neutropenia.
D000328:Adult; D000368:Aged; D001284:Atrophy; D002446:Celiac Disease / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D019327:Copper Sulfate; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D003300:Copper; D019327:Copper Sulfate