Interference with high performance liquid chromatographic chloramphenicol assay in a patient receiving dobutamine.
We report potential interference by dobutamine with our high performance liquid chromatography (HPLC) procedure for assaying chloramphenicol succinate and chloramphenicol. Interference was discovered in a 1-year-old boy receiving chloramphenicol succinate and dobutamine. The identity of the interfering substance was confirmed by HPLC and gas chromatography.
D002395:Catecholamines / Q000097:blood*; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D004280:Dobutamine / Q000097:blood*; D006801:Humans; D007223:Infant; D008297:Male; D008991:Monitoring, Physiologic; D011183:Postoperative Complications / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy
D002395:Catecholamines; D004280:Dobutamine; D002701:Chloramphenicol; C026016:chloramphenicol succinate