Oncogenes and linkage groups: conservation during mammalian chromosome evolution.
Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS-all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years.
D000818:Animals; D005075:Biological Evolution; D002875:Chromosomes / Q000502:physiology*; D002999:Clone Cells; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000302:isolation & purification; D008040:Genetic Linkage; D006822:Hybrid Cells / Q000166:cytology; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D013154:Spleen
D004247:DNA