[Determination by 15N tracer kinetics of the half-life of total body protein in premature and mature infants].
Based on 15N-tracer techniques important data of the intermediary protein metabolism can be assessed by compartment analysis. We calculated the half-life of whole body proteins in five preterm and five full term infants in addition to commonly used parameters of the protein metabolism e.g. protein synthesis rate, protein breakdown rate, N-turnover rate, size of metabolic pool, half-life and reutilization of aminoacid-N and the rate of endogenous urinary-N. The infants were aged 27 +/- 4 and 31 +/- 13 days resp. The half-life of whole body proteins were found to be 7.5 +/- 1.8 days in the premature infants and thus significantly shorter than the 16.0 +/- 3.8 days for the full term infants. The differences in the half-life of protein as well as protein synthesis rate and protein breakdown rate reflect the rapid proteinturnover in premature infants in comparison to full term infants.
D000596:Amino Acids / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001823:Body Composition; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009590:Nitrogen Radioisotopes; D011506:Proteins / Q000378:metabolism*
D000596:Amino Acids; D001798:Blood Proteins; D009590:Nitrogen Radioisotopes; D011506:Proteins
Zur 15N-tracerkinetischen Bestimmung der Halbwertszeit des Gesamtkörperproteins bei frühgeborenen und reifgeborenen Säuglingen.