Different course of acute hepatitis B in elderly adults.
A retrospective study on 50 young and 35 aged patients with acute hepatitis B was performed. Clinical and laboratory parameters were evaluated. The most significant results obtained in the aged group when compared with the young were longer hospitalization, less elevated serum glutamic-pyruvic transaminase, serum bilirubin and alkaline phosphatase significantly higher, lower IgM and higher IgA levels. The results indicate that acute hepatitis B in elderly adults is characterized by a milder liver cell necrosis and a hypercholestatic pattern. The possible causes for these features are discussed.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007902:Length of Stay; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin