Disorders of cobalamin (vitamin B12) absorption and transport.
Highly specialized mechanisms are required for transporting cobalamin (vitamin B12) into and out of mammalian cells. This review describes the key role of the cobalamin-binding proteins in meeting the stringent requirements for transport of this essential nutrient. Also summarized are the various defects capable of impairing intestinal absorption and transcellular transport of cobalamin. Elucidation of these defects proved crucial for our current understanding of normal cobalamin transport mechanisms.
D001693:Biological Transport, Active; D006801:Humans; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D011485:Protein Binding; D014805:Vitamin B 12 / Q000378:metabolism*; D014806:Vitamin B 12 Deficiency / Q000378:metabolism
D014805:Vitamin B 12