Dolichols and enzymatic formation of dolichyl phosphate sugars in the thymus of mice on neoplastic transformation.
The content of dolichol in thymus gland of mice increased up to four times upon malignant transformation evoked by X-ray irradiation of animals or/and in the case of spontaneous tumours as compared with normal thymus. Dolichyl phosphate mannose and dolichyl pyrophosphate N-acetylglucosamine were formed in homogenates of transformed thymus at a higher rate than in normal gland.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000528:radiation effects; D004224:Diterpenes / Q000378:metabolism*; D004287:Dolichol Monophosphate Mannose / Q000378:metabolism; D004288:Dolichol Phosphates / Q000378:metabolism*; D004286:Dolichols / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011105:Polyisoprenyl Phosphate Sugars / Q000378:metabolism*; D011106:Polyisoprenyl Phosphates / Q000378:metabolism*; D013953:Thymus Neoplasms / Q000378:metabolism*; D014965:X-Rays
D004224:Diterpenes; D004288:Dolichol Phosphates; D004286:Dolichols; D011105:Polyisoprenyl Phosphate Sugars; D011106:Polyisoprenyl Phosphates; D004287:Dolichol Monophosphate Mannose