[Effect of furosemide on the permeability of the wall of intact and ischemic nephrons in the rat].
It has been established in acute experiments on rats that furosemide reduces the supply of uranine from the lumen of renal tubules to the interstitial space and systemic blood flow. Complete disconnection of the renal blood flow for 1 h dramatically raises the permeability of the epithelial barrier of the tubules. Administration of furosemide before disconnection of the renal circulation is accompanied by an increase of uranine transport from the nephron lumen to the blood as compared with the control. However, this response is less pronounced than in experiments with renal ischemia without the use of the diuretic.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D019793:Fluorescein; D005452:Fluoresceins / Q000494:pharmacology; D005665:Furosemide / Q000494:pharmacology* / Q000627:therapeutic use; D007511:Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D007684:Kidney Tubules / Q000187:drug effects; D008433:Mathematics; D009399:Nephrons / Q000098:blood supply / Q000187:drug effects*; D051381:Rats
D005452:Fluoresceins; D005665:Furosemide; D019793:Fluorescein
Vliianie furosemida na pronitsaemost' stenki intaktnykh i ishemizirovannykh nefronov pochek krys.