Bone mineral and vitamin D in Aleutian Islanders.
Serum concentrations of vitamin D metabolites (chromatography) and bone mineral status (125I absorptiometry) were examined in a group of Aleutian Islanders age 40-75 from St Paul Island, Alaska. Based on 25-(OH)D (16.6 ng/ml) vitamin D status appeared adequate. However, high concentrations of 1,25-(OH)2D (44.3 pg/ml) and very low concentrations of 24,25-(OH)2D3 (0.6 ng/ml) were found. Among females, low bone mineral levels were associated with high concentrations of 1,25-(OH)2D. A low calcium intake in these Aleutians may be responsible for high concentrations of 1,25-(OH)2D and resorption of calcium from bone.
D000328:Adult; D000368:Aged; D000413:Alaska; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010024:Osteoporosis / Q000453:epidemiology; D012737:Sex Factors; D014807:Vitamin D / Q000097:blood*
D008903:Minerals; D014807:Vitamin D