Effect of eosinophilia on the heterogeneity of the anticoagulant response to heparin in haemodialysis patients.
The anticoagulant response to heparin was determined, during haemodialysis, in a group of seven patients with eosinophilia and in a control group. The heparin half-life was similar in the two groups, but the heparin effect index was lower in patients with eosinophilia. The dose-response curve showed a reduced sensitivity to heparin in patients with eosinophilia. In patients with eosinophilia a significant reduction in eosinophil count was observed during cuprophan dialysis, but not during polyacrylonitrile dialysis. The hyposensitivity to heparin might be related to eosinophil degranulation, during cuprophan dialysis, with release of a major basic protein that neutralises heparin.
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D004351:Drug Resistance; D004802:Eosinophilia / Q000097:blood*; D005260:Female; D006493:Heparin / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D006493:Heparin