Failure to warfarin to affect the tissue factor activity and the metastatic potential of murine fibrosarcoma cells.
Vitamin K deficiency, either dietary or pharmacologically induced by warfarin, was unable to affect the metastatic capacity of cells from a benzopyrene-induced fibrosarcoma in C57BL/6J mice. The same cells had a procoagulant activity, of tissue thromboplastin type, which was also completely unaffected by vitamin K antagonism or deficiency. In another murine model of spontaneous metastasis we previously suggested that depression of a particular procoagulant such as a direct factor X activator might contribute to the antimetastatic activity of warfarin. The failure of vitamin K deficiency to affect both the procoagulant and the metastatic capacity of the model reported here offers strong negative support to the same concept.
D000818:Animals; D005354:Fibrosarcoma / Q000097:blood / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000473:pathology*; D013925:Thromboplastin / Q000378:metabolism*; D014813:Vitamin K Deficiency / Q000150:complications; D014859:Warfarin / Q000627:therapeutic use*
D014859:Warfarin; D013925:Thromboplastin