Hypertension in mesangial IgA glomerulonephritis.
Blood pressure in 75 patients with IgA nephropathy (IgA-GN), confirmed by renal biopsy, was related to clinical, immunological and morphological findings. The findings were compared with an age-matched control group of patients with non-IgA-GN. Overall prevalence of hypertension (HT) was similar in IgA-GN and non-IgA-GN (38.7% vs 38.2%). The presence of HT in IgA-GN was related to age, renal function, immunohistological pattern and degree of glomerular sclerosis or vascular lesions respectively. No correlation was found between HT and elevated serum IgA, circulating IgA immune complexes and IgA skin deposits. The current observations underline the value of hypertension for predicting development of renal failure. Vascular lesions are not only strongly correlated with, but may even precede development of, hypertension as confirmed by longitudinal observations.
D000293:Adolescent; D000328:Adult; D005921:Glomerulonephritis / Q000150:complications; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008875:Middle Aged