Digitalis receptors and digoxin sensitivity in renal failure.
The number and the in vitro and in vivo affinity of digitalis receptors for digoxin were measured in patients with normal renal function and in uraemics. In uraemic patients the number of receptors was decreased. Although their in vitro affinity for digoxin was unchanged the in vivo affinity was decreased, probably due to hyperkalaemia. These findings provide a possible pharmacodynamic explanation for decreased activity of cardiac glycosides in chronic renal failure.
D000328:Adult; D000368:Aged; D004077:Digoxin / Q000378:metabolism / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D007700:Kinetics; D008875:Middle Aged; D010042:Ouabain / Q000494:pharmacology; D011955:Receptors, Drug / Q000378:metabolism*; D006435:Renal Dialysis; D000254:Sodium-Potassium-Exchanging ATPase
D011955:Receptors, Drug; C027082:digitalis receptor; D010042:Ouabain; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase