[Oxygen consumption in nerve centers. Effect of cyproheptadine hydrochloride on normal and alcohol-treated rats].
The effect of CLH-CP (Cyproheptadine Chlorhydrate) on the oxidative activity of the nervous centers involved in the control of ingestion: hypothalamus, anterior cortex, amygdala and septal area, has been studied in normal and alcoholized male rats. The statistical analysis of the results showed that O2 consumption decreased significantly with CLH-CP in all studied structures except the hypothalamus in the alcoholized group, whereas no modification of O2 consumption in the normal group had been observed after treatment with CLH-CP, which may be related to the assayed dose. There are further significant differences in O2 consumption between normal and alcoholized groups without treatment with CLH-CP, the O2 consumption being significantly higher in the latter group and in all the studied structures except the hypothalamus where the O2 consumption significantly decreased in the alcoholized group as compared to the normal group. These latter differences disappeared when the structures of both groups were treated with CLH-CP. On the basis of these observations the results of the CLH-CP effect in both animal groups are discussed.
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003533:Cyproheptadine / Q000494:pharmacology*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012688:Septum Pellucidum / Q000187:drug effects / Q000378:metabolism
D003533:Cyproheptadine; D000431:Ethanol
Consumo de O2 en centros nerviosos. Efecto del clorhidrato de ciproheptadina en ratas normales y alcoholizadas.