A proposed plan for the detection and identification of potential sensitizers.
For toxicologists who are actively involved in safety testing and risk assessment, the ideal animal model should accurately predict the biologic response of humans after any contact with potentially hazardous materials. Unfortunately this goal is seldom, if ever, approached. Therefore, the toxicologist must design and execute experiments that will define to a higher degree of accuracy the inherent toxicity of the chemical and the biological response of the model. If the biologic response can be defined and understood and if the relevant information is available for comparable human responses, then the extrapolation to the human situation, although not always precise, can be made with a measure of assurance. Finally, and perhaps most importantly, it is essential that follow-up on human exposures be in sufficient detail so that the variations in biologic response can be further defined. In this way the precision and accuracy of the safety assessment can be checked.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology; D004195:Disease Models, Animal; D004342:Drug Hypersensitivity / Q000209:etiology*; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D012882:Skin Tests; D013045:Species Specificity