Delayed gastric emptying with dothiepin.
Dothiepin induced symptoms of delayed gastric emptying in an elderly lady. Rechallenge studies were undertaken and demonstrated a delay in gastric emptying of liquid after re-administration of dothiepin at a time when plasma concentrations were 93 micrograms/l. Elderly patients may be more susceptible to the anticholinergic effects of tricyclic antidepressants on the gut.
D000368:Aged; D003864:Depression, Chemical; D003988:Dibenzothiepins / Q000009:adverse effects*; D004308:Dothiepin / Q000009:adverse effects*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D010276:Parasympatholytics / Q000009:adverse effects*
D003988:Dibenzothiepins; D010276:Parasympatholytics; D004308:Dothiepin