[Role of serotonin and dopamine receptors in the mechanism of action of haloperidol and pirenperone].
The effects of haloperidol, a typical neuroleptic, and pirenperone, a selective blocker of serotonin-2-receptors, were studied and compared. Acute administration of haloperidol had effects mainly in dopaminergic models, whereas pirenperone was active only in serotoninergic models. Chronic administration of both drugs made the systems indicated hypersensitive. This effect may be important in the mechanism of action of neuroleptic drugs.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013134:Spiperone / Q000378:metabolism; D013997:Time Factors
D010880:Piperidines; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D011814:Quipazine; D013134:Spiperone; D000661:Amphetamine; D006220:Haloperidol; D001058:Apomorphine; C034177:pirenperone
Rol' serotoninovykh i dofaminovykh retseptorov v mekhanizme deĭstviia galoperidola i pirenperona.