[Effect of pargyline on the response to CO2 stress].
The effects of pargyline administration during three days on male rats for stress reaction caused by hypercapnia, taking into account the contents of noradrenaline in the left auricle, the right auricle, the ventricle, the spleen and the hypothalamus have been studied. The stress by CO2 only produces a significant depletion of noradrenaline at the hypothalamus level. The administration of pargyline (50 mg/kg/day) induces significant increases in the content of noradrenaline in all the tissues. The increases in noradrenaline content are greater when the pargyline is given before the stress.
D000818:Animals; D006935:Hypercapnia / Q000188:drug therapy* / Q000378:metabolism; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D009206:Myocardium / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D013154:Spleen / Q000032:analysis; D013312:Stress, Physiological / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism
D008996:Monoamine Oxidase Inhibitors; D010293:Pargyline; D008995:Monoamine Oxidase; D009638:Norepinephrine
Efecto de la pargilina sobre la respuesta al estrés por CO2.