[Clinical studies on ceftriaxone in the field of obstetrics and gynecology].
Clinical studies were made on ceftriaxone (CTRX, Ro 13-9904), a new long-acting cephalosporin antibiotic, with the following results. Following a single intravenous injection of 1 g, the transfer of CTRX to the internal genital organs was found to be good. The transfer of CTRX to exudate of the dead space of pelvis was also good. Elbow vein and uterine artery blood serum levels revealed marked increase immediately after administration, then followed by gradual reduction at very slow rate. CTRX was given to 3 patients of female genital infections. Efficacy was excellent in 1 case and good in 2 cases. As to side effect, 2 cases of diarrhea and 1 case of leukopenia were observed.
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002439:Cefotaxime / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002443:Ceftriaxone; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy*; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy*; D013492:Suppuration / Q000188:drug therapy; D014591:Uterine Diseases / Q000188:drug therapy*
D002443:Ceftriaxone; D002439:Cefotaxime