Effect of folic acid treatment in the fragile X syndrome.
The effect of folic acid intake on the frequency of fragile X positive cells and some behavioural characteristics were evaluated in 5 boys and 4 adult males with the fragile X syndrome. The expression of fragile X was nullified in 6 and decreased in 3 of the 9 patients. Behavioural and motor ability were considered to have improved in 4 of the 5 boys but not in the 4 adults with fragile X syndrome.
D000293:Adolescent; D001519:Behavior / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002873:Chromosome Fragility; D005492:Folic Acid / Q000627:therapeutic use*; D005600:Fragile X Syndrome / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012729:Sex Chromosome Aberrations / Q000188:drug therapy*; D013997:Time Factors
D005492:Folic Acid