[Effects of human urinary trypsin inhibitor against operative stress].
Effects of human urinary trypsin inhibitor (MTI) against operative stress were investigated. Laparotomy in a mouse caused suppression of immunological functions such as phagocytic activity and antibody formation, followed by loss of resistivity to bacterial infection and acceleration of growth of concealed tumor. The operation also caused damages to the body such as enhancement of protein catabolism and suppression of renal function, followed by increase of blood urea nitrogen, increase of protease activity in skeletal muscle and suppression of PSP clearance. Since MTI wholly ameliorated these undesirable conditions of the body caused by operative stress, it was suggested that MTI has an effect on maintaining the homeostasis of the living body as well as the ability to inhibit trypsin.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000517:prevention & control; D010587:Phagocytosis / Q000187:drug effects; D011183:Postoperative Complications / Q000517:prevention & control; D011512:Proteus Infections / Q000517:prevention & control; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D014361:Trypsin Inhibitors