Facial skin temperature in chlorpropamide alcohol flush.
Objective methods to study the chlorpropamide alcohol flush (CPAF) have been inadequate. Determination of blood acetaldehyde has proved to be a promising method, but the analysis is difficult and time-consuming. To measure the facial skin temperature is more handy. The results of these measurements can be presented as delta T (skin temperature increase), %T (per cent of maximum possible temperature rise) or delta MTCI (malar thermal circulation index) after calculations. The baseline skin temperature is accounted for in %T and delta MTCI. Blood acetaldehyde determinations and placebo-alcohol tests can be used to separate the CPAF reaction from alcohol flushing. Single dose CPAF tests including facial skin temperature measurements were performed in 133 type 2 (non-insulin dependent) diabetics. Facial flush was observed in 42.9%. The specificity and sensitivity of all three skin temperature methods were high: 88.2, 85.5, 96.1%, and 89.5, 86.0, 86.0%, respectively. Skin temperature measurement, whether expressed as delta T, %T or delta MTCI, provides a method to study CPAF with high accuracy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002747:Chlorpropamide; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D000431:Ethanol / Q000494:pharmacology*; D005145:Face / Q000098:blood supply; D005260:Female; D005483:Flushing / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012881:Skin Temperature / Q000187:drug effects*
D000431:Ethanol; D002747:Chlorpropamide