Serum lactate dehydrogenase isoenzyme-1 in children with yolk sac tumor.
Although in recent years the evidence of an increase in serum lactate dehydrogenase isoenzyme-1 (LDH-1) in patients with germ cell tumor (GCT) has attracted attention, there have only been a few reports concerning yolk sac tumor (YST), which is a frequent type of GCT in childhood. Serum LDH isoenzymes were determined in eight children with YST, and an increase in LDH-1 was found in seven of them, excluding one in an early stage. On the basis of the findings of serial serum LDH-1 levels during treatment and of LDH isoenzyme pattern in tumor tissues, it is presumed that the increased serum LDH-1 is derived from tumor tissues. LDH-1 seems to be useful as a tumor marker, not specific for YST but associated with the whole spectrum of GCT, for monitoring of YST.
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D008297:Male; D008649:Mesonephroma / Q000201:enzymology* / Q000473:pathology / Q000556:secondary; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000473:pathology; D012445:Sacrococcygeal Region; D013736:Testicular Neoplasms / Q000201:enzymology / Q000473:pathology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase