Intestinal absorption of ursodeoxycholic, glycoursodeoxycholic and tauroursodeoxycholic acids in rats.
We examined the intestinal absorption of ursodeoxycholic acid (UDC), glycoursodeoxycholic acid (GUDC) and tauroursodeoxycholic acid (TUDC) using an everted gut sac technique. UDC was absorbed throughout rat small intestine almost to the same extent. Absorption of both GUDC and TUDC, however, varied between jejunum and ileum. Absorption of these conjugated bile acids in the jejunal segments was less than that of UDC. While, absorption of GUDC and TUDC in the terminal ileum was more efficient than UDC. Although 2,4-dinitrophenol had no effect on the jejunal uptake, ileal uptake of these three bile acids was inhibited by 2,4-dinitrophenol.
D000818:Animals; D001693:Biological Transport, Active; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013655:Taurochenodeoxycholic Acid / Q000378:metabolism*; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*
D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; C031655:ursodoxicoltaurine; C024033:glycoursodeoxycholic acid; D014580:Ursodeoxycholic Acid