Cholecystokinin and bombesin suppress operant responding for food reward.
The effects of intraperitoneal injections of cholecystokinin (CCK) and bombesin (BBS) on food-rewarded operant responding were investigated. Response rates were significantly suppressed following administrations of CCK (0.7, 1.4, and 2.9 micrograms/kg). The effects appeared to be dose dependent. Responding was also suppressed following injections of BBS (6 and 16 micrograms/kg). These results confirm and extend previous findings concerning the possible function of these peptides.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005502:Food; D006815:Hunger / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000187:drug effects
D010455:Peptides; D002766:Cholecystokinin; D001839:Bombesin