[Morphologic findings of the secretory epithelium of the ampulla following ethacrynic acid].
The effect of ethacrynic acid (dose 60 mg./kg. and 100 mg./kg.) on the secretory epithelium of guinea pig ampulla and semicircular epithelium was investigated. With high doses of ethacrynic acid and after long periods (3-4 hours) only, discrete electron microscopic alterations were seen. These consisted mainly in swelling of mitochondria, increase of vesicles, and movement or destruction of melanocytes. Interstitial oedema, well-documented in stria vascularis, was not observed.
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D004976:Ethacrynic Acid / Q000494:pharmacology*; D006168:Guinea Pigs; D008854:Microscopy, Electron; D012665:Semicircular Canals / Q000187:drug effects* / Q000648:ultrastructure; D013316:Stria Vascularis / Q000187:drug effects
D004976:Ethacrynic Acid
Morphologische Befunde am sekretorischen Epithel der Ampulle nach Ethacrynsäure.