Metastatic neuroblastoma in an infant: translocation (1;11), deletion (2) and double minute chromosomes.
An extensive chromosomal analysis was performed in cells of primary tumour and bone marrow metastases from an 8-month-old girl with disseminated neuroblastoma prior to therapy. A modal chromosome number of 46 was found. Consistent abnormalities in the karyotype were seen: in particular, a translocation (1;11), a deletion (2)(p21) and a chromosome 7p+. Furthermore, double minute chromosomes of two distinct sizes were found in 50%-80% of metaphases in the cell populations examined. These extra chromosomal double minutes might be the cytogenetic form of amplified cellular oncogene-DNA.
D000310:Adrenal Gland Neoplasms / Q000235:genetics*; D001853:Bone Marrow / Q000648:ultrastructure; D001859:Bone Neoplasms / Q000235:genetics / Q000556:secondary*; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D009447:Neuroblastoma / Q000235:genetics / Q000556:secondary*; D014178:Translocation, Genetic