[Evaluation of the effects of anabolic steroids, calcitonin and 25-hydroxycholecalciferol on the spongy bone of rats].
Prevention of the experimental bone rarefaction which occurs in rats put on a low calcium diet was attempted by using salmon calcitonin and 25 hydroxyvitamin D given with a similar regimen to that used in human disease. Results were compared with the previously reported effects of synthetic anabolic steroids. Statistical analysis was carried out on measurements of cancellous bone mass. No statistically significant increase in the femoral trabecular bone volume occurred in rats put on an hypocalcemic diet plus treatment by calcitonin and vitamin D whereas such an increase had been noted when anabolic steroids were used. Measurement of the trabecular bone volume of proximal and distal epiphyses demonstrated a statistically significant difference between rats on a hypocalcemic diet treated by 25-OH-D3 and rats treated by calcitonin or controls on a normal diet. In rats on a normal diet, 25 hydroxyvitamin D led to an increase in bone mass which did not reach statistical significance but is probably explained by improvement in calcium intestinal absorption.
D045930:Anabolic Agents / Q000627:therapeutic use*; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects*; D002112:Calcifediol / Q000627:therapeutic use*; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000172:deficiency; D002136:Calcium, Dietary / Q000008:administration & dosage; D004838:Epiphyses / Q000473:pathology; D005260:Female; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D045930:Anabolic Agents; D002136:Calcium, Dietary; C028815:salmon calcitonin; D002116:Calcitonin; D002112:Calcifediol; D002118:Calcium
Evaluation des effets sur l'os spongieux du rat des anabolisants, de la calcitonine et du 25-hydroxycholécalciférol.