Effect of interferon tested in a model system for organogenesis.
The effect of interferon (IFN) on growth and differentiation was examined in a model system for organogenesis--the embryonic murine kidney and its components. A relatively weak, transient inhibition of thymidine incorporation was recorded during the most active period of DNA synthesis in the presence of IFN at a concentration of 10(5) U/ml. No interference with cytodifferentiation or organogenesis could be shown by the end-point criteria used.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D007370:Interferon Type I / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013936:Thymidine / Q000378:metabolism
D007370:Interferon Type I; D013936:Thymidine