The inhibitory effects of beta-momorcharin on endometrial cells in the mouse.
beta-Momorcharin purified from the seeds of Momordica charantia L. suppressed the decidual response of pseudopregnant mouse uterus to mechanical stimulus. In the beta-momorcharin-treated uterus, stromal cells failed to decidualise, uterine glands distended, and a diminished cell proliferation was found in the endometrium and myometrium. beta-Momorcharin also inhibited the biosynthetic activity of the cultured endometrial cells. The rate of incorporation of 3H-thymidine, 3H-uridine and 3H-leucine was all depressed by beta-momorcharin. The termination of the early pregnancy in the mouse may have resulted from an inhibitory effect of the abortifacient protein on the differentiating endometrium.
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003656:Decidua / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects*; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D010940:Plant Proteins / Q000494:pharmacology*; D011247:Pregnancy; D011555:Pseudopregnancy; D012269:Ribosomal Proteins; D054788:Ribosome Inactivating Proteins; D014599:Uterus / Q000187:drug effects
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D010940:Plant Proteins; D012269:Ribosomal Proteins; C039582:MMC protein, Momordica charantia; D054788:Ribosome Inactivating Proteins