Hyperpigmentation in megaloblastic anemia.
Generalized hyperpigmentation developed over 2 years in a 65-year-old woman. A diagnosis of pernicious anemia was made, and treatment with vitamin B12 led to complete reversion of her hyperpigmentation to normal. Literature pertinent to hyperpigmentation and its association with megaloblastic anemias is reviewed and several possible mechanisms are mentioned.
D000368:Aged; D000752:Anemia, Pernicious / Q000150:complications* / Q000188:drug therapy; D002648:Child; D005260:Female; D006801:Humans; D010859:Pigmentation Disorders / Q000209:etiology*; D014805:Vitamin B 12 / Q000627:therapeutic use
D014805:Vitamin B 12