[HPLC studies on the distribution behavior of guanyl- and N-phenylguanylhydrazone derivatives].
The article in hand presents first HPLC studies on the distribution behaviour of guanylic and N-phenylguanylic hydrazone derivates. The chromatographic parameters of compounds, which had been separated at NH2-columns by 0.06 mol X 1(-1) Na2HPO4 buffer/methanole (30 : 70), could be identified, and the k'/rates could be utilized for the calculation of the coefficient of distribution. As a result of performed calculations of the correlation, it could be proved that the log. P rates which had been ascertained by the HPLC method, been determined by the shaked flash method and been calculated acc. to Leo, correlate to the 1% significant level.
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D006146:Guanidines; D008935:Mitoguazone / Q000031:analogs & derivatives* / Q000032:analysis
D006146:Guanidines; D008935:Mitoguazone
HPLC-Untersuchungen zum Verteilungsverhalten von Guanyl- und N-Phenylguanylhydrazonderivaten.