Effect of chlorpromazine on peritoneal clearances.
Chlorpromazine added to the dialysate improved the ultrafiltration and increased peritoneal clearances of urea and inulin. These results were postulated to be due to the narrowed stagnant dialysate fluid layer by the surface-active property of chlorpromazine. The study suggested another way to improve large solute (possibly uremic toxin) transport by using substances that facilitate convective transport. Intraperitoneal chlorpromazine increased the peritoneal dialysis efficiency.
D002746:Chlorpromazine / Q000494:pharmacology*; D002908:Chronic Disease; D006801:Humans; D007444:Inulin / Q000378:metabolism*; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D013500:Surface Tension; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism*; D014511:Uremia / Q000628:therapy
D014508:Urea; D007444:Inulin; D002746:Chlorpromazine