A strain of hairless mouse susceptible to tumorigenesis by TPA alone: studies with 8-methoxypsoralen and solar simulated radiation.
Hairless albino mice were painted with 8-methoxypsoralen (8-MOP) and exposed to solar simulated radiation (SSR) for 0, 3 or 6 weeks and subsequently treated with the promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). TPA was highly tumourigenic in non-pretreated mice. Pretreatment with 8-MOP + SSR did not increase this level of tumorigenesis. It is proposed that 8-MOP + SSR tumour induction was the result of promotion of innate initiated cells and that this mouse strain might be useful as a promoter testing model.
D000818:Animals; D003043:Cocarcinogenesis; D005260:Female; D008730:Methoxsalen / Q000633:toxicity*; D051379:Mice; D008812:Mice, Hairless; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011701:PUVA Therapy / Q000009:adverse effects; D010704:Phorbols; D013472:Sunlight / Q000009:adverse effects*; D013755:Tetradecanoylphorbol Acetate
D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate; D008730:Methoxsalen