Why was the 1918 influenza pandemic so lethal? The possible role of a neurovirulent neuraminidase.
Epidemiological, viral, behavioral and neuropathological evidence suggests that some influenza epidemics were neurovirulent. Re-examination of the data from the lethal 1918 pandemic armed with recent observations about the influenza virus implicates a neurovirulent influenza virus in manic-depressive disease, schizophrenia and Parkinson's disease. The neurovirulence seems to have been related to the species of neuraminidase.
D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000473:pathology; D004196:Disease Outbreaks; D004660:Encephalitis / Q000209:etiology* / Q000276:immunology / Q000401:mortality; D006801:Humans; D007251:Influenza, Human / Q000401:mortality; D009439:Neuraminidase / Q000633:toxicity*; D009975:Orthomyxoviridae / Q000201:enzymology* / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
D000956:Antigens, Viral; D009439:Neuraminidase