A new principle of RNA folding based on pseudoknotting.
Tertiary interactions involving hairpin or interior loops of RNA can lead to extended quasi-continuous double helical stem regions, consisting of coaxially stacked segments of duplex RNA, bridged by single-stranded connections. This type of compact folding plays a role in various strategic regions of RNA molecules. Their role in ribosome functioning, RNA splicing and recognition of tRNA-like structures is discussed.
D001483:Base Sequence; D003201:Computers; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D012326:RNA Splicing; D012343:RNA, Transfer / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis*; D012270:Ribosomes / Q000502:physiology
D012367:RNA, Viral; D012343:RNA, Transfer