[Changes in the permeability of nerve fiber membranes during the initiation of lipid peroxidation].
The role of lipid oxidation in the mechanism of ion transport was investigated. During initiation of lipid oxidation by actin "Fe2+--ascorbic acid" in the crab nerve 45Ca and 22Na accumulation and level of lipid oxidation were increased, but electric stimulation of the nerve greatly changed ion accumulation. Increased Na+Ca2+ accumulation during the initiation of lipid oxidation is explained not only by changes in the lipid phase of excitable membranes but by the effects of rhythmic excitation on potential-dependent channels.
D000200:Action Potentials; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D003386:Brachyura; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D005296:Ferrous Compounds / Q000378:metabolism; D066298:In Vitro Techniques; D007552:Isotonic Solutions; D008054:Lipid Peroxides / Q000378:metabolism*; D009412:Nerve Fibers / Q000378:metabolism* / Q000502:physiology; D000077331:Ringer's Solution; D012964:Sodium / Q000378:metabolism
D005296:Ferrous Compounds; D007552:Isotonic Solutions; D008054:Lipid Peroxides; C020748:ferrous sulfate; D000077331:Ringer's Solution; D012964:Sodium; D001205:Ascorbic Acid; D002118:Calcium
Izmenenie pronitsaemosti membran nervnykh volokon v usloviiakh initsiatsii perekisnogo okisleniia lipidov.