[Effect of tuftsin on the activity of energy metabolism enzymes in peritoneal macrophages].
Cytochemistry was used to measure the activity of succinate dehydrogenase (SOD), lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) in rat peritoneal macrophages under the action of the endogenous immunostimulant tuftcin (tre-lys-pro-arg) during phagocytosis of latex particles and at rest. Tuftcin did not affect the activity of the study enzymes in non-phagocytic cells. Elevation of the peptide concentration to 0.25 micrograms/ml and higher in phagocytic macrophages activated G-6-PDH and lowered the activity of LDH. Tuftcin did not alter the activity of SOD in phagocytic macrophages.
D000818:Animals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D010587:Phagocytosis; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014405:Tuftsin / Q000494:pharmacology*
D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D014405:Tuftsin
Vliianie taftsina na aktivnost' nekotorykh fermentov énergeticheskogo metabolizma peritoneal'nykh makrofagov.