Antibiotic aerosolization: the effect on experimentally induced Alcaligenes rhinotracheitis in turkeys.
Oxytetracycline hydrochloride was delivered by aerosol twice daily for 3 days to uninfected turkeys and to turkeys experimentally inoculated with Alcaligenes faecalis. The clinical, microbiological, and histological changes in the upper respiratory tracts were studied. No lesions were observed in the tracheas of uninoculated poults exposed to the aerosol. In experimentally infected poults, clinical signs included ocular and nasal discharges and open-mouthed breathing. Histologic lesions included progressive bacterial colonization of ciliated epithelium, loss of cilia, depletion of mucin from goblet cells, and accumulation of inflammatory cells within the tracheal lumen. Aerosolization of oxytetracycline effected a temporary decrease in bacterial colonization and a delay in clinical signs and histologic lesions in infected treated poults compared with untreated infected poults. Bacterial colonization and histologic lesions in the tracheas of both treated and untreated infected poults were similar by 4 days after the treatment was discontinued. This study indicates additional research with bactericidal antibiotics is needed to further evaluate antibiotic aerosolization as a treatment for alcaligenes rhinotracheitis.
D000336:Aerosols; D000421:Alcaligenes / Q000187:drug effects; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000473:pathology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012220:Rhinitis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014132:Trachea / Q000473:pathology; D014136:Tracheitis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014422:Turkeys
D000336:Aerosols; D010118:Oxytetracycline