[Effect of dimethoxy dichloro vinyl phosphate and fluorostigmine on the cyclic nucleotide content and dopamine level in the brain nigrostriatal system].
Study of the levels of cAMP, cGMP and dopamine in the caudate nucleus of rats 30 min and 24 h after acute poisoning with fluorostigmine or dimethoxy dichlorovinyl phosphate (DDVP) has shown that at the acute period the content of cGMP was elevated only in grave poisonings (by 46% after administration of fluorostigmine and by 64% after DDVP). Following 24 h the changes in the content of cAMP and cGMP were found to be retained only in the group of rats which received fluorostigmine (a 21% reduction and 27% rise, respectively). The dopamine level at the acute period was discovered to be altered only in mild patterns of poisoning (a 1.5-fold increase). After 24 h all the groups of animals demonstrated a 1.3-1.4 lowering of dopamine content.
D000208:Acute Disease; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004006:Dichlorvos / Q000506:poisoning*; D004298:Dopamine / Q000378:metabolism*; D007531:Isoflurophate / Q000506:poisoning*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D062025:Organophosphate Poisoning; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects* / Q000378:metabolism
D009712:Nucleotides, Cyclic; D007531:Isoflurophate; D004006:Dichlorvos; D004298:Dopamine
Vliianie dimetoksidikhlorvinilfosfata i fliuorostigmina na soderzhanie tsiklicheskikh nukleotidov i uroven' dofamina v nigrostriatnoĭ sisteme mozga.