Nutritional studies on Paracoccidioides brasiliensis: the role of organic sulfur in dimorphism.
The nutritional requirements of the mycelial and yeast-like phases of the dimorphic fungus Paracoccidioides brasiliensis, a human pathogen, were investigated. For all nine isolates tested, mycelial cells were prototrophic, whereas yeast-like cells required a sulfur-containing amino acid for growth. Moreover, changing the source of nitrogen greatly affected the morphology of the yeast-like cells.
D000603:Amino Acids, Sulfur / Q000378:metabolism; D003470:Culture Media; D005658:Fungi / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D010228:Paracoccidioides / Q000254:growth & development / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism*
D000603:Amino Acids, Sulfur; D003470:Culture Media; D013455:Sulfur; D009584:Nitrogen