[Frequency of sensitization to D. pteronyssinus or D. farinae in children with perennial bronchial asthma].
Bronchial sensitization against house dust mites (dermatophagoides farinae, dermatophagoides pteronyssinus) was investigated in 48 children. The therapeutic effect of hyposensitization and removal of house dust mite allergen was evaluated. The diagnosis was established by skin-prick-test, RAST and bronchial provocation. The bronchial provocation test was carried out by a whole body plethysmograph with breath by breath registration of the airway resistance. We found a bronchial reaction against both mites in 70% of the children; 18% showed bronchial reaction only against d. farinae, 10% only against d. pteronyssinus. There was a better correlation between RAST and bronchial provocation (69,5%) than between skin-prick-test and bronchial provocation (65%). The correlation concerning the skin-brick-test and RAST was 55% with d. farinae and 59% with d. pteronyssinus. There was no correlation between PRIST and RAST, RAST and eosinophiles, therapeutic effects of hyposensitization and positive allergen tests. After one year of therapy, the conditions of 87,5% (only mite sensitization) respectively 92% (mixed sensitization) of patients improved. Another group of sensitized children was only treated by removal of house dust mite allergen and anti-allergic and bronchodilating drugs. 43% (mixed allergy) respectively 54% (only mite sensitization) had less asthma problems. After the hyposensitization the children showed a significant improvement. There was no difference in the therapeutic effect after hyposensitization against d. farinae or d. pteronyssinus.
D000293:Adolescent; D000328:Adult; D000946:Antigens, Fungal / Q000276:immunology*; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D004391:Dust / Q000009:adverse effects*; D006801:Humans; D007428:Intradermal Tests; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000628:therapy
D000946:Antigens, Fungal; D004391:Dust
Häufigkeit der Sensibilisierung gegen D. pteronyssinus oder D. farinae bei Kindern mit ganzjährigem Asthma bronchiale.