Quantitative determination of amoxicillin and its decomposition products by high-performance liquid chromatography.
Amoxicillin, amoxicilloates, amoxicillin oligomers and amoxicillin piperazine-2,5-dione are separated by reversed-phase (C8) high-performance liquid chromatography with gradient elution. Quantitative results are reported for a number of samples. Amoxicillin trihydrate samples mostly contain amoxicilloate as the main impurity. Samples of the sodium salt also contain the piperazine-2,5-dione and the dimer. Higher oligomers such as the trimer and tetramer were not present in significant amounts. Several samples were also analysed by a mercurimetric titration method.
D000658:Amoxicillin / Q000031:analogs & derivatives / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D007536:Isomerism
D000658:Amoxicillin