Dynamic changes of the chicken erythrocyte membranes induced by N-methyl-N-aryl-N-nitrosoureas and their tumorigenicity.
The dynamic changes of chicken erythrocyte membranes induced by a series of N-methyl-N'-aryl-N-nitrosoureas (I X) were investigated in comparison with those of N-methyl-N-nitrosourea (MNU) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by electron spin resonance spectroscopy. Both I X and MNNG increased the intensity of the less mobile lipid component (h1) during the incubation while MNU decreased it. The more mobile lipid component (h2), however, was not much influenced by these agents. A positive correlation was observed between the degree of the spectral alterations (h2/h1) caused by I-X compounds and their tumorigenic potency on mouse skin with the exception of the chloride derivative (I-C1). The present results suggest that the reactions of ultimate carcinogens with cell membranes may play an important role in the tumor promoting process.
D000818:Animals; D002273:Carcinogens; D002645:Chickens; D004910:Erythrocyte Membrane / Q000187:drug effects*; D066298:In Vitro Techniques; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D008770:Methylnitrosourea / Q000633:toxicity; D051379:Mice; D009607:Nitrosourea Compounds / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced; D012995:Solubility
D002273:Carcinogens; D009607:Nitrosourea Compounds; D008769:Methylnitronitrosoguanidine; D008770:Methylnitrosourea