Galactocerebroside antiserum causes demyelination of cat optic nerve.
A model of immune-mediated optic nerve demyelination is described. Micro-injection of small volumes (less than 5 microliter) of high titer polyclonal anti-Gal-C serum into the cat optic nerve resulted in a focal, highly selective demyelinative lesion followed by remyelination. Demyelination appears to be due to a dual effect on myelin and on oligodendrocytes. The numbers of these cells within the lesion were initially reduced but subsequently increased as remyelination occurred.
D000818:Animals; D002415:Cats; D002554:Cerebrosides / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005699:Galactosylceramides / Q000276:immunology*; D007106:Immune Sera / Q000633:toxicity; D008854:Microscopy, Electron; D009900:Optic Nerve / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000473:pathology
D002554:Cerebrosides; D005699:Galactosylceramides; D007106:Immune Sera; C002454:galactocerebroside