[Course of serum alkaline phosphatase during treatment with isoniazid and rifampicin].
In a population of 132 tuberculous children coming from immigrant families, statistical analysis of data showed a significant increase in serum alkaline phosphatase levels. This phenomenon is more significant when several antibiotics are used (Isoniazid and Rifampicin) than when monotherapy is used (Isoniazid). These results demonstrate a high tendency to occult osteomalacia in tuberculous patients treated by tuberculostatic drugs.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D012189:Retrospective Studies; D012293:Rifampin / Q000009:adverse effects*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000469:Alkaline Phosphatase; D007538:Isoniazid; D012293:Rifampin
Evolution de la phosphatase alcaline sérique sous traitement d'isoniazide et de rifampicine.