[Oral amoxicillin for purulent meningitis in the child: early relief and reduction in symptoms].
The pharmacokinetics of amoxycillin in the CSF following intravenous and oral administration at a 150 mg/kg per day or 250 mg/kg per day dosage in the treatment of purulent meningitis is described. A significant correlation between meningeal inflammation and CSF levels of amoxycillin were observed, including a correlation between the initial neurological state and the outcome of the illness. Despite the early introduction of oral therapy and the reduction in dosage following meningeal and pneumococcal meningitis, no treatment failures could be attributed to this therapeutic regime. Such a treatment schedule, moreover, reduces the risk of superinfection in hospital as well as the cost of treatment and aids the comfort to the patient.
D000284:Administration, Oral; D000658:Amoxicillin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003365:Costs and Cost Analysis; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D007700:Kinetics; D008585:Meningitis, Meningococcal / Q000188:drug therapy*; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*
D000658:Amoxicillin
Amoxicilline orale dans les Méningites purulentes de l'enfant: relais précoce et réduction de la posologie.