Interaction of biodegradable beta-whitlockite ceramics with bone tissue: an in vivo study.
The biodegradation of different porous beta-whitlockite materials are studied by in vivo experiments, radiographic follow-ups and light microscopy observations. The materials were implanted in rabbit tibiae for 16 month. Micropores play an important role in the biodegradation rate. The resorbing materials evoke an inflammation with plasma cells. The resorption starts in the medulla, and the phagocytosed particles are removed to the lymph nodes. Normal bone function can be restored after all the implant material is resorbed.
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000166:cytology* / Q000000981:diagnostic imaging / Q000187:drug effects; D002130:Calcium Phosphates / Q000494:pharmacology*; D002516:Ceramics; D019736:Prostheses and Implants; D011817:Rabbits; D011859:Radiography; D013997:Time Factors
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C021767:whitlockite