The interaction of dietary vitamin A and vitamin D related to skeletal development in the turkey poult.
Large white male turkey poults were fed diets with different levels of vitamins A and D to study the interaction of these vitamins with regard to skeletal development. Poults fed a basal diet deficient in both vitamins A and D developed severe lameness, growth depression, mortality and lesions consistent with rickets. Birds fed a diet containing the required level of vitamin D (900 ICU/kg, NRC estimated requirement) and a high level of vitamin A (400,000 IU/kg) also developed severe lameness, growth depression and a rachiticlike condition, characterized by thicker than normal proximal tibial epiphyseal plates and lower than normal bone mineral content. When fed a diet containing the required level of vitamin A (4,000 IU/kg, NRC estimated requirement) and a high level of vitamin D (900,000 ICU/kg), poults developed hypervitaminosis D as evidenced by mild growth depression and renal tubular mineralization. When poults were fed a diet containing high levels of both vitamins A and D growth rate and bone mineral content were similar to control poults fed a diet containing the required levels of vitamins A and D. In addition, lameness and renal tubular mineralization were not apparent in the poults fed a diet containing high levels of both vitamins A and D. It was concluded that there is an antagonistic interaction between vitamins A and D.
D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism; D004032:Diet; D004347:Drug Interactions; D008297:Male; D008903:Minerals / Q000378:metabolism; D011201:Poultry Diseases / Q000378:metabolism / Q000503:physiopathology; D011859:Radiography; D012279:Rickets / Q000662:veterinary; D014422:Turkeys / Q000254:growth & development*; D014801:Vitamin A / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism / Q000503:physiopathology / Q000662:veterinary
D008903:Minerals; D014801:Vitamin A; D014807:Vitamin D