Chylous effusions due to neuroblastoma resolved by intrapleural chlorambucil coupled to father's antibodies.
A 2-year-old boy presented with a stage IV neuroblastoma and, despite surgical reduction of the tumor mass followed by chemotherapy and radiotherapy, he developed bilateral chylous pleural effusions. These proved resistant to traditional methods of treatment but were resolved with minimal discomfort to the child by intrapleural injections of chlorambucil chemically bound to antibodies raised by immunizing his father with irradiated tumor cells.
D000912:Antibodies, Neoplasm / Q000008:administration & dosage* / Q000627:therapeutic use; D002675:Child, Preschool; D002699:Chlorambucil / Q000008:administration & dosage* / Q000627:therapeutic use; D002913:Chyle; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005220:Fathers; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D007167:Immunotherapy; D008297:Male; D009447:Neuroblastoma / Q000150:complications* / Q000628:therapy; D010996:Pleural Effusion / Q000188:drug therapy* / Q000209:etiology
D000912:Antibodies, Neoplasm; D004338:Drug Combinations; D007074:Immunoglobulin G; D002699:Chlorambucil