Normetanephrine and metanephrine oxidized by both types of monoamine oxidase.
Both normetanephrine and metanephrine were found to be oxidized by both types of monoamine oxidase in mouse liver mitochondria. Both Km and Vmax values of type B MAO for both substrates were higher than those of type A MAO, which caused the shift of inhibition curves with clorgyline and deprenyl according to the increase in substrate concentration.
D000818:Animals; D004837:Epinephrine / Q000031:analogs & derivatives*; D007527:Isoenzymes / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008676:Metanephrine / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D008930:Mitochondria, Liver / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009647:Normetanephrine / Q000378:metabolism*; D013379:Substrate Specificity
D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D009647:Normetanephrine; D008676:Metanephrine; D008995:Monoamine Oxidase; D004837:Epinephrine