Screening human populations for chromosome aberrations.
In order to determine the usefulness of micronuclear counts (MNC) for identifying people with relatively high frequencies of chromosome aberrations we have examined factors that influence the MNC in a learning set of blood samples obtained from 28 adults. The presence of cells with chromosome aberrations among approximately 170 metaphase cells per sample was the most important factor. Controlling for the effect of chromosome aberrations we found that age had a significant effect on MNC, but that donor sex, the mitotic index, the per cent of metaphase cells in the second or third division or the frequency of abnormal anaphase cells did not. Using logistic regression analysis we found that MNC was an excellent predictor of the presence of cells with chromosome aberrations among both the learning set and a test set of 17 additional blood samples.
D002467:Cell Nucleus / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012044:Regression Analysis