Effects of human chorionic gonadotrophin, oestradiol and estromustine on testicular blood flow in hypophysectomized rats.
The effects of human chorionic gonadotrophin (hCG), eostradiol benzoate (E2) and estromustine (Eo) on testicular and prostatic blood flow and plasma levels of testosterone were studied in hypophysectomized rats. Daily injections of 5 IU hCG induced a significant increase in testicular blood flow when measured after 8-9 days treatment. This stimulatory effect was inhibited by concomitant injection of E2 (50 micrograms/day) but not by Eo. In contrast, the stimulatory effect of hCG on plasma levels of testosterone was inhibited by administration of E2 as well as by Eo. This inhibition was correlated with decreased blood flow to the prostate. The present study gives further support to the hypothesis the oestrogens have direct effects on the testis and prostate.
D000818:Animals; D001794:Blood Pressure; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004702:Endocrine Glands / Q000187:drug effects; D004822:Epididymis / Q000098:blood supply; D004958:Estradiol / Q000494:pharmacology*; D004970:Estrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007016:Hypophysectomy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011467:Prostate / Q000098:blood supply; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013268:Stimulation, Chemical; D013737:Testis / Q000098:blood supply*
D006063:Chorionic Gonadotropin; D009588:Nitrogen Mustard Compounds; D004970:Estrone; D004958:Estradiol; C012115:Leo 271 f; D007986:Luteinizing Hormone