Analysis of the renal tissue of a woman chronically exposed to cadmium.
In a 61-year-old woman, who had been exposed for 20 years to cadmium in the production of Ni-Cd batteries, nephrectomy of the contracted kidney was performed. The removed kidney was examined histologically and the cadmium concentration was determined in the cortex (44.97 micrograms g-1) and in the medulla (7.71 micrograms g-1). The homogenates of the renal cortex and medulla were subjected to gel filtration on Sephadex G-75. In the cortex, as well as the medulla, cadmium was predominantly found in the low-molecular (metallothionein) fraction, but in the cortex, Cd content in this fraction was six times higher than in the medulla. The determination of SH groups and proteins in high- and low-molecular fractions indicates an induction of the metallothionein formation primarily in the renal cortex.
D002104:Cadmium / Q000032:analysis / Q000633:toxicity*; D004781:Environmental Exposure; D005260:Female; D005978:Glutathione / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000032:analysis / Q000187:drug effects*; D008875:Middle Aged; D009392:Nephrectomy
D002104:Cadmium; D005978:Glutathione