Piracetam attenuates the changes in the surface potential of the phosphatidylcholine monolayer produced by alcohols.
The surface potential changes produced by three alcohols on the phosphatidylcholine (PC) monolayer, either alone or in combination with piracetam were studied. The PC monolayer was formedon 145 mM KCL in a teflon trough and the surface change was measured by means of a Kiethley electrometer, with the high impedence output connected to an Americium 241 air electrode and the low impedence output to a calomel reference electrode. The alcohols produced a negative going change in the surface charge of the monolayer, proportional to the chain length of carbon atoms and amount of alcohol added. 10 microliter (2 mg) of piracetam applied to the PC monolayer before adding the alcohols partially inhibited the changes produced by them. It seems that in vitro piracetam opposes the action of alcohols on this membrane model.
D000438:Alcohols / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D010713:Phosphatidylcholines; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*
D000438:Alcohols; D010713:Phosphatidylcholines; D011760:Pyrrolidinones; D010889:Piracetam