Incorporation of aluminium and effect of removal in experimental osteomalacia and fibro-osteoclasia.
Osteomalacia (OM) and fibro-osteoclasia (FO) was induced in growing rats by feeding a low calcium, low phosphorus, vitamin D poor diet or a low calcium diet respectively. After two weeks, Al Cl3 was supplemented up to a content of 0.1% of elemental Al and feeding continued for another two weeks, when half of the animals were sacrificed and the rest treated with desferrioxamine. In spite of similar blood aluminium concentrations, OM rats retained more Al in bone than FO rats. Desferrioxamine (DFO) treatment resulted in a significant decrease of Al in OM rats and tended to decrease Al in FO rats. Simultaneously the per cent mineral weight of the bone increased. We conclude that the preexisting bone pathology (OM or FO) is related to aluminium uptake and removal by DFO, which results in rapid mineral uptake.
D000535:Aluminum / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D001862:Bone Resorption; D003676:Deferoxamine / Q000627:therapeutic use; D010018:Osteomalacia / Q000378:metabolism*; D051381:Rats
D000535:Aluminum; D003676:Deferoxamine