Stability conditions of cell populations in vivo.
Specific exogenous stimulating and inhibiting substances act on cell proliferation and differentiation rates. An additional internal regulatory mechanism is shown to be necessary to ensure the regulation of cell proliferation in vivo. Various internal regulatory mechanisms have been envisaged. Stability conditions and experimental data led us to reject all of them except those postulating that an inhibitory signal produced by the differentiating cells acts on the rate of cell proliferation. This finding supports the theory concerning the mechanism of action of "chalone-like" inhibiting substances.
D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D000078404:Epidermal Cells; D005246:Feedback; D006801:Humans; D007399:Interphase; D008433:Mathematics; D008938:Mitosis; D008954:Models, Biological; D014945:Wound Healing