Effect of fusaric acid (a dopamine beta-hydroxylase inhibitor) on phaeochromocytoma.
Fusaric acid, an inhibitor of dopamine beta-hydroxylase, which converts dopamine to noradrenaline, lowered the blood pressure and induced a subjective improvement in patients with phaeochromocytoma. These effects may be due either to an impairment of catecholamine biosynthesis or to a direct action on the blood vessels. The use of this drug in the treatment of patients with inoperable malignant phaeochromocytoma or neuroblastoma may improve symptoms and prolong survival.
D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000652:urine; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors* / Q000097:blood; D004837:Epinephrine / Q000652:urine; D005669:Fusaric Acid / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine; D010673:Pheochromocytoma / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D010848:Picolinic Acids / Q000627:therapeutic use*
D010848:Picolinic Acids; D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine