The effects of chronic lithium on the EEG and locomotor response to drug challenge in rats.
Adult male Wistar rats were given lithium as a dietary supplement or a control diet for a period of eight weeks. Spectral analysis of cortical EEG activity revealed a significant shift in the amplitude and variance of the theta rhythm in rats administered lithium. A significant increase in the locomotor response to morphine over time but not to saline or caffeine was seen in lithium treated rats as compared to controls. The modulation of the locomotor response to morphine seen following lithium administration suggests the possibility that modification of a brain opioid system may contribute to the clinical response to lithium.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D002110:Caffeine; D009020:Morphine; D008094:Lithium