Use of RU 25960, a new calcium antagonist, in normobaric and hypobaric hypoxia.
RU 25960--3-[Bis(3,3-diphenylpropyl)-amino]-propan-1-ol hydrochloride--a vasodilator with calcium antagonist properties, was tested on learning in hypobaric hypoxic rats and survival time in normobaric hypoxic mice. It decreased learning in hypobaric hypoxia, but did not change survival time in mice. This suggests that the mechanisms underlying learning and survival are not the same, and that like other calcium antagonists, RU 25960 has no protective effect against the deleterious effects of hypoxia on the brain.
D000337:Aerospace Medicine; D000532:Altitude Sickness / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000633:toxicity; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D000860:Hypoxia / Q000139:chemically induced / Q000188:drug therapy*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011412:Propanolamines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats
D002121:Calcium Channel Blockers; D011412:Propanolamines; C006074:PF-244