Experimental emphysematous bullae induced by methylcholanthrene and carrageenan.
An animal model for the emphysematous bullae in the rabbit lung induced by methylcholanthrene and carrageenan was reported. In early stages (by 2 months) the cystic lesions associated with extensive pneumonia. In later stages the inflammation subsided and only the cystic lesions remained, resulting in typical, large emphysematous bullae.
D000818:Animals; D002351:Carrageenan / Q000633:toxicity*; D003560:Cysts / Q000139:chemically induced / Q000473:pathology; D004357:Drug Synergism; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity*; D009336:Necrosis; D011014:Pneumonia / Q000139:chemically induced / Q000473:pathology; D011656:Pulmonary Emphysema / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits
D008748:Methylcholanthrene; D002351:Carrageenan