[Comparison of the level of sister chromatid exchanges and chromosome aberrations induced by chemical mutagens in vitro and in vivo].
The paper presents results of a study of a dose dependence of induction of SCE and chromosomal aberrations at the exposure of human lymphocytes in vitro and bone marrow cells of mice in vivo to 5 alkylating chemicals. The efficiency of SCE induction in vitro is found to be 300-30 times as high as that of arising of chromosomal aberrations. The same regularity is observed in experiments in vivo, but the ratio is reduced to 60-20 times.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D009153:Mutagens
Sopostavlenie urovnia sestrinskikh khromatidnykh bmenov i khromosomnykh aberratsiĭ, indutsirovannykh khimicheskimi mutagenami in vitro i in vivo.