The effect of various aldehydes on the respiration of rat liver and hepatoma AH-130 cells.
Some aldehydes, produced during lipid peroxidation of liver lipids, are able to inhibit the respiration of mitochondria and of intact cells both in normal hepatocytes and in Yoshida hepatoma. In mitochondria, the respiratory stimulation produced by addition of ADP and dinitrophenol is decreased more in hepatoma than in normal liver. Two- to four-fold higher concentrations of aldehydes are needed to obtain the same degree of inhibition in normal liver mitochondria as in tumorous organs. The effect of aldehydes on intact cell respiration is absent or very low in hepatocytes, but it is consistently observed in hepatoma cells.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000447:Aldehydes; D008054:Lipid Peroxides; D005978:Glutathione