[Induction of chromosome aberrations in human lymphocytes by cyclophosphamide action in vivo and in vitro].
The dose dependences of chromosome aberrations rate were investigated in lymphocytes of oncological patients after cyclophosphamide (CP) administration. It was shown that the rate of chromosome aberrations and the number of disruptions per cell in vivo and in vitro increases exponentially with the dose. At the same time, the parameters of regression equations coincide. This evidences that CP has the similar effect in vivo and in vitro.
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013997:Time Factors
D003520:Cyclophosphamide
Induktsiia khromosomnykh aberratsiĭ v limfotsitakh cheloveka pri deĭstvii tsiklofosfamida in vivo i in vitro.