Effects of single cortical spreading depression on metabolic heat production in the rat.
The effect of a single cortical spreading depression (CSD), elicited unilaterally by 10% KCI injection at the occipital cortex, was observed on the metabolic heat production in the rat with unilateral lesions in the preoptic and anterior hypothalamus (PO/AH). The metabolic rate increased by maximally 20% above its pre-CSD level for 7 min with a rise in rectal temperature when CSD entered the frontal cortex contralateral to the PO/AH lesion. By contrast, with the same onset, the increase in metabolic rate was lower (maximum 12%) and of shorter duration (3 min) in the ipsilateral CSD trial. Non-CSD trial with 0.9% NaCl injection had no effect on metabolic rate. The results provide further evidence to support the view that the frontal cortex of the rat is involved in the central thermoregulation.
D000818:Animals; D001833:Body Temperature Regulation; D001931:Brain Mapping; D013181:Cortical Spreading Depression; D005625:Frontal Lobe / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000502:physiology*; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology; D011301:Preoptic Area / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D011189:Potassium Chloride