Studies of the effects of spherulin from Coccidioides immitis on human polymorphonuclear leukocytes.
The effects of spherule lysate (spherulin) on human polymorphonuclear leukocyte (PMN) function was examined. PMN adherence to glass and capping was increased by spherulin, findings which may account for spherulin's interference with complement-mediated migration through cellulose ester filters. In contrast, PMN attachment to yeast, killing of bacteria, and effects on spherules were virtually unaffected by spherulin, suggesting that it does not directly inhibit PMN antimicrobial function.
D000946:Antigens, Fungal / Q000276:immunology*; D001770:Blood Bactericidal Activity; D002175:Candida / Q000276:immunology; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte; D003045:Coccidioides / Q000276:immunology*; D003046:Coccidioidin / Q000276:immunology*; D006801:Humans; D007152:Immunologic Capping; D009504:Neutrophils / Q000276:immunology*
D000946:Antigens, Fungal; C009303:spherulin; D003046:Coccidioidin