Effects of maternal administration of diethylstilbestrol and estradiol on the newborn guinea pig.
The subcutaneous injection of diethylstilbestrol (2.5 micrograms/day) into pregnant guinea pigs from the 28th or 40th day to term resulted in an accelerated tempo of differentiation of the genital tract of the female offspring at birth, as well as intense estrogenic stimulation. Estradiol (50 micrograms per day) injected over the same period caused insignificant estrogenic stimulation in the newborn. The normal embryogenesis of the genital tract is described and a pattern of caudocranial differentiation identified. The normal genital tract is described as a basis for the analysis of results in the newborn. Comparative studies in other animals are discussed.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005836:Genitalia, Female / Q000033:anatomy & histology / Q000187:drug effects / Q000196:embryology; D006168:Guinea Pigs; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D004958:Estradiol; D004054:Diethylstilbestrol