NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: support of steroid hydroxylation.
In gerbil adrenal cortex the activity of intramitochondrial NADP-linked isocitric dehydrogenase (IDH) is up to 10-fold greater than the NAD-linked IDH. The NADP-IDH, apparent Km 0.58 mM, Vmax 280 nmoles/min/mg mitochondrial protein, appears to be the major source of reducing equivalents to support adrenal mitochondrial steroid 11B- and 19-hydroxylation in this species.
D000311:Adrenal Glands / Q000201:enzymology*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D005849:Gerbillinae / Q000378:metabolism*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D013250:Steroid Hydroxylases / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D000735:Androstenedione; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; C039355:isocitrate dehydrogenase (NADP+); D013250:Steroid Hydroxylases