Chronic changes in male rats' hormone-sensitive systems after suprathreshold pulses of testosterone.
Adult male rats were castrated and maintained on daily SC injections of a threshold amount (200 micrograms) of testosterone propionate (TP). To mimic naturally occurring pulses of suprathreshold testicular hormones in intact males, animals in the experimental groups also received either one (single TP) or five (multiple TP) injections of 800 micrograms TP over 12 days. The rats were examined on the following day (acute) or 15 days later (chronic) for changes in hormone-sensitive behavior, physiology, and morphology. The hypothesis tested was that the hormonal pulses function to provoke chronic changes in substrates underlying the reproductive system. The results were that multiple doses of suprathreshold TP provoked acute modifications in aggressive behavior, sex accessory glands, and glans penis integrity. Chronic changes were observed in sex accessory gland functioning and penile morphology, particularly in the size of penile papillae. A single exposure to suprathreshold TP was considerably less effective, though there was some evidence of acute changes in sex accessory glands and chronic changes in penile papillae. There was substantial variation in the responses of individual animals, particularly the chronic responses. The data were interpreted as supporting the hypothesis.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002369:Castration; D004056:Differential Threshold; D005837:Genitalia, Male / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology* / Q000502:physiology; D013997:Time Factors
D013739:Testosterone