A convenient synthesis of the potent mutagen 3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine.
The highly mutagenic title compound (4,8-DiMeIQx) was synthesized in 13% overall yield from 2-fluoro-5-nitrotoluene in eight operations. The average operation yield was 83%. The reaction sequence used gave, in addition to the title compound, the isomer 3,4,7-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine (4,7-DiMeIQx).
D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis*; D051381:Rats
D009153:Mutagens; D011810:Quinoxalines; C045421:3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine