6-Nitrochrysene is a potent tumorigen in newborn mice.
A newborn mouse (BLU:Ha) lung adenoma bioassay demonstrated that 6-nitrochrysene was a highly potent tumorigen. It induced 100% incidence of lung tumors and a 150-fold increase in their number (20.84 tumors/mouse) at the lowest dose level tested (total dose: 38.5 micrograms/mouse). 70% of the 6-nitrochrysene treated mice had malignant lung tumors (adenocarcinomas). Lymphomas and nodular hyperplasia of the liver were also observed in treated, but not control, animals. The tumorigenicity of 6-nitrochrysene relative to other polynuclear aromatic hydrocarbons and their mononitro-derivatives has been discussed.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D002911:Chrysenes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D010616:Phenanthrenes / Q000633:toxicity*
D002273:Carcinogens; D002911:Chrysenes; D010616:Phenanthrenes; C035986:6-nitrochrysene