Teratologic evaluation of Alcide liquid in rats and mice. I.
Alcide, a liquid sterilizer, was evaluated for teratogenic potential in rats and mice. Sodium chlorite and lactic acid, the active ingredients of this compound, form chlorine dioxide when mixed. Pregnant rats and mice were administered 1 ml and 0.1 ml, respectively, of Alcide liquid by gavage on days 6-15 of gestation. The general health of the dams was evaluated and the fetuses examined for external, visceral and skeletal malformations. There was no evidence of maternal toxicity among treated rats and mice. Fetal viability, weight, length and number of resorptions were comparable with control groups. Teratogenic toxicity was not detected in either species. There was some incidence of skeletal and visceral anomalies; however, these variances were not significantly different from control animals.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities; D002713:Chlorine / Q000633:toxicity*; D017606:Chlorine Compounds; D002853:Chromatography, Liquid; D004202:Disinfectants / Q000633:toxicity; D005260:Female; D005865:Gestational Age; D051379:Mice; D010087:Oxides / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013045:Species Specificity; D013723:Teratogens
D017606:Chlorine Compounds; D004202:Disinfectants; D010087:Oxides; D013723:Teratogens; D002713:Chlorine; C025109:chlorine dioxide