[Degradation of DNA and chromatin in cells of mouse lymphoid organs after irradiation and PHA administration].
Phytohemagglutinin (PHA) administered to irradiated mice did not influence the postirradiation degradation of DNA and the yield of polydeoxynucleotides (PDN) in cells of thymus, spleen and bone marrow. The degree of degradation of DNA and chromatin was higher in the thymus as compared to other studied organs. A possible mechanism of the radiotherapeutic action of PHA is discussed.
D000818:Animals; D002843:Chromatin / Q000378:metabolism* / Q000528:radiation effects; D004247:DNA / Q000378:metabolism* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008221:Lymphoid Tissue / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism*; D011836:Radiation Tolerance; D013997:Time Factors
D002843:Chromatin; D010835:Phytohemagglutinins; D004247:DNA
Degradatsiia DNK i khromatina v kletkakh limfoidnykh organov mysheĭ posle oblucheniia i vvedeniia FGA.