A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county, China.
Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.
D000818:Animals; D002681:China; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004938:Esophageal Neoplasms / Q000209:etiology*; D005670:Fusarium / Q000378:metabolism*; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D009153:Mutagens; D011090:Polyenes / Q000302:isolation & purification*; D012854:Sister Chromatid Exchange; D003313:Zea mays / Q000382:microbiology*
D009153:Mutagens; D011090:Polyenes; C041403:fusarin C