The effects of post-heparin plasma lipases on anti-Xa clotting activity.
The effects of hepatic triglyceride lipase (HTGL) and lipoprotein lipase (LPL) on the anti-Xa clotting activity of plasma were studied. LPL had no effect, but HTGL enhanced anti-Xa activity. This enhancement was shown to be due to a time-dependent action of HTGL on lipoproteins. These results could explain the increases in anti-Xa clotting activity previously observed after injection of heparin analogues, SSHA and SP54, which are potent releasers of lipase enzymes.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005170:Factor X / Q000037:antagonists & inhibitors*; D015951:Factor Xa; D006493:Heparin; D006801:Humans; D007700:Kinetics; D008049:Lipase / Q000097:blood / Q000494:pharmacology*; D008071:Lipoprotein Lipase / Q000097:blood / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats
D005170:Factor X; D006493:Heparin; D008049:Lipase; D008071:Lipoprotein Lipase; D015951:Factor Xa