[Abnormal hemoglobins identified in Martinique].
Epidemiologic programs in Martinique during the last 10 years and particularly the last 5, have allowed the determination of the Hb S, Hb C, beta thalassemia traits frequencies. A number of rare variants have been detected during the course of these screening programs. Many of these Hb variants have been analysed at the structural level. For some of them a pathologic interaction with Hb S is observed (Hb D Punjab, Hb O Arab...), and the use of electrophoretic mobilities obtained with the reference samples provides the basis of a rapid, highly probable presumptive identification and then, a useful tool, when for example genetic counselling is necessary.
D004812:Epidemiologic Methods; D006444:Hemoglobin C / Q000302:isolation & purification; D006451:Hemoglobin, Sickle / Q000302:isolation & purification; D006455:Hemoglobins, Abnormal / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008395:Martinique; D010641:Phenotype; D012805:Sickle Cell Trait / Q000097:blood; D013789:Thalassemia / Q000097:blood
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; C032001:hemoglobin D; D006444:Hemoglobin C
Hémoglobines anormales identifiées à la Martinique.