The in vitro cytotoxic effect of bilirubin on human lymphocytes and granulocytes.
Using an in vitro cytotoxicity assay (51Cr-release), it was shown that bilirubin exerts a cytotoxic effect on both adult and newborn human lymphocytes after a 1-d incubation of cells with bilirubin. The effect of bilirubin on human granulocytes was less pronounced; the association of the cytotoxic effect with a functional immunological perturbation of these cells is discussed.
D000328:Adult; D001663:Bilirubin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*
D001663:Bilirubin