Hydrogen peroxide has a role in the aggregation of human platelets.
The aggregation of platelets induced by soluble and particulate stimuli is enhanced by the addition of minute amounts of H2O2. Externally added catalase strongly inhibits the aggregation induced by particulate stimuli and by phorbol myristate acetate (PMA). The addition of aminotriazole to stimulated platelets causes a significant inhibition of intracellular catalase. This indicates the formation of H2O2 inside the platelets during activation. No effects were observed when the platelets were stimulated by the ionophore A23187.
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000640:Amitrole / Q000494:pharmacology; D002374:Catalase / Q000037:antagonists & inhibitors / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D015054:Zymosan / Q000494:pharmacology
D011450:Prostaglandin Endoperoxides, Synthetic; D000244:Adenosine Diphosphate; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D003094:Collagen; D015054:Zymosan; D006861:Hydrogen Peroxide; D002374:Catalase; D013917:Thrombin; D013755:Tetradecanoylphorbol Acetate; D000640:Amitrole