Desferrioxamine induced aluminium removal in haemodialysis.
This study evaluates if the use of high flux membranes and the type of dialysate influences aluminium removal in haemodialysis. Aluminium kinetics and dialysance were determined in baseline conditions and after infusion of desferrioxamine. The free diffusible fraction of plasma aluminium correlated significantly with the plasma aluminium post desferrioxamine, independently of the type of membrane or dialysate used. Aluminium removal therefore depends on the plasma concentration reached and the dialysate concentration. High flux membranes do not improve aluminium removal in vivo.
D000535:Aluminum / Q000097:blood* / Q000302:isolation & purification; D003676:Deferoxamine / Q000627:therapeutic use*; D006801:Humans; D006435:Renal Dialysis / Q000379:methods*
D000535:Aluminum; D003676:Deferoxamine