Allosensitization in tumor therapy and prophylaxis, and in female contraception--a prospect for clinical use.
A hypothesis is presented on the possible role of allosensitization in therapy and prophylaxis of human tumors, and in human female contraception. The essence of the proposed treatment of human malignancies is allosensitization with allogeneic white blood cells by means of application of two blood transfusions from normal healthy donors within a certain time interval to patients with invasive or metastasizing cancer. The therapy should be accompanied by immunoglobulins, bacterial toxins and a single dose of cytostatics. In the case of a successful tumor regression a prophylaxis of recurrence should be made with two doses of intradermally injected allogeneic lympho-leucocytic concentrates mixed with bacterial toxins; such treatment might also be effective in tumor prophylaxis, or in long-lasting contraception in women. The hypothesis is supported by recent literature as well as by our recent results in the area of cell-mediated control of tissue proliferation, fetal allograft survival or tumor development. It is concluded that tumor rejection can be mediated not only by the direct effect of anti-tumor drugs but more effectively by the organisms mechanisms responsible for removal of undesirable tissue.
D001803:Blood Transfusion; D003267:Contraception; D003269:Contraception, Immunologic; D005260:Female; D006801:Humans; D007114:Immunization; D017708:Leukocyte Transfusion; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D014184:Transplantation, Homologous