Drug-induced liver injury in liver biopsies of the years 1981 and 1983, their prevalence and type of presentation.
Based on the histological picture of liver biopsies examined in the years 1981 and 1983, drug-induced liver injury has been suspected in 131 and 170 cases. In relation to the total number of the examined liver biopsies this accounted for 6 and 9.6%, respectively. In only 20 (i.e. 15%), respectively 17 (i.e. 10%) of the cases, a drug-induced injury could be clinically excluded. However, a drug-induced injury was doubtlessly secured in 21 (16%) and 28 (16.5%) of the cases. The histological phenotype seen in association with the incriminated drug is presented. In 90 (68.7%) and 125 (73.5%) of the cases it was neither possible to secure nor to exclude the drug as cause of this damage, either because in 32/72 cases the clinical work-up was incomplete or because the drug-induced damage was clinically suspected, but not sufficiently documented by follow-up examinations after drug-withdrawal.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006099:Granuloma / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000473:pathology; D006521:Hepatitis, Chronic / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged