Isotypic and idiotypic characterization of anti-bee venom phospholipase A2 antibodies.
It was shown that anti-bee venom phospholipase A2 antibodies (anti-PLA) of bee keepers belong mainly to the IgG4 class. Furthermore anti-PLA of different individuals are idiotypically related to each other. This was shown by the binding of heterologous antiidiotypic antibodies, produced against anti-PLA IgG from single donors, to anti-PLA F(ab')2 of different individuals. Therefore, the anti-PLA response provides a human model to study the idiotypic regulation of isotypes in a defined system.
D000906:Antibodies / Q000145:classification*; D001514:Bee Venoms / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007074:Immunoglobulin G / Q000145:classification; D007130:Immunoglobulin Idiotypes / Q000145:classification; D007299:Insect Bites and Stings / Q000276:immunology*; D010740:Phospholipases / Q000276:immunology*; D010741:Phospholipases A / Q000276:immunology*; D054467:Phospholipases A2
D000906:Antibodies; D001514:Bee Venoms; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2