Ciamexone--a new highly selective immunosuppressive compound.
A local graft versus host reaction between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir). In this local mixed lymphocyte reaction mainly T-helper cells and B-cells are involved. An induction of a delayed type hypersensitivity reaction with oxazolon significantly decreases the local graft versus host reaction. Cyclosporin A depresses the local graft versus host reaction and the delayed type hypersensitivity in mice whereas Ciamexone, a 2-cyanaziridine derivative, very selectively only suppresses the local graft versus host reaction and increases the delayed type hypersensitivity.
D000818:Animals; D001388:Aziridines / Q000008:administration & dosage / Q000494:pharmacology*; D001389:Azirines / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006968:Hypersensitivity, Delayed / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008198:Lymph Nodes / Q000033:anatomy & histology; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D010081:Oxazolone / Q000494:pharmacology
D001388:Aziridines; D001389:Azirines; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D010081:Oxazolone; C035520:ciamexon