[Cardio- and hemodynamics of dogs in exposure of the heart to immune complexes].
The cardiovascular effects induced by in-vitro obtained immune complexes (horse serum antigens--rabbit specific antibodies) were studied in dogs. Intracoronary administration of immune complexes was followed by the development of a hypotensive reaction, with a marked decrease in the cardiac output, left ventricle performance, and impairment of pump heart function. After administering immune complexes no marked injuries to the myocardium or depression of its contractility were recorded in the acute period of the reaction. A substantial decrease of venous blood return to the heart caused by blood pooling in the venous peripheral vascular bed underlies pump heart function impairment and the decreased cardiac output.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000008:administration & dosage / Q000276:immunology*; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects*; D006736:Horses / Q000276:immunology; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology; D066298:In Vitro Techniques; D011817:Rabbits; D012769:Shock / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors
D000936:Antigen-Antibody Complex
Kardio- i gemodinamika u sobak pri deĭstvii na serdtse immunnykh kompleksov.