Contact urticaria from diethyl fumarate.
The contact urticariagenic properties of diethyl fumarate were studied using the guinea pig ear swelling assay and by open application on the human upper back skin. Diethyl fumarate caused non-immunologic contact urticaria in both human and guinea pig skin, and the reactions exhibited similar dose dependency and timing of maximal response.
D000328:Adult; D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D005650:Fumarates / Q000009:adverse effects*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced*
D005650:Fumarates; C035088:diethyl fumarate