Lack of effect of liver disease on the pharmacokinetics of acebutolol and diacetolol: a single dose study.
The pharmacokinetics of acebutolol and its major metabolite, diacetolol, following a single 400 mg oral dose, were investigated in patients with liver disease. No significant differences were found in any of the parameters measured.
D000070:Acebutolol / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
C025527:diacetolol; D000070:Acebutolol