Hyperprolactinemia and estrogen-induced rhythms in LH and prolactin release in the ovariectomized rat.
Short-term (9 days) hyperprolactinemia induced by pituitary grafts reduced basal plasma LH levels in ovariectomized rats whereas long-term (31 days) grafts increased basal LH levels. Although long-term grafts inhibited estradiol-induced prolactin surges, hyperprolactinemia had no effect on the LH surge. It is concluded that the estrogen-treated ovariectomized rat is not suitable for studying the effects of hyperprolactinemia on LH release.
D000818:Animals; D002369:Castration; D002940:Circadian Rhythm / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood*; D010902:Pituitary Gland / Q000637:transplantation; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone