Complement activation and anaphylactoid response to protamine in a child after cardiopulmonary bypass.
A 2 1/2 year old boy had a sudden, severe, and unexpected anaphylactoid reaction after an otherwise uncomplicated repair of a partial atrioventricular septal defect. The reaction, comprising haemorrhagic pulmonary oedema and peripheral circulatory collapse, followed neutralisation of heparin by protamine. Measurements of serum complement (C3 and C4) concentrations suggested that a pronounced consumption of complement occurred during the adverse response.
D000707:Anaphylaxis / Q000097:blood / Q000139:chemically induced*; D002315:Cardiopulmonary Bypass; D002675:Child, Preschool; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D006801:Humans; D008297:Male; D011184:Postoperative Period; D011479:Protamines / Q000009:adverse effects*
D003176:Complement C3; D003181:Complement C4; D011479:Protamines