[Statural growth following irradiation of the central nervous system for medulloblastoma of the posterior fossa. Retrospective analysis of 45 cases].
Treatment of medulloblastoma in children with head and spinal irradiation causes growth hormone deficiency and growth retardation. The present study deals with 45 patients presenting a follow-up time superior to 4 years; some of them having reached their final height. The mean final height is 3 standard deviations below normal mean. Growth retardation which occurred in 42 of 45 children, appears to be due to two major factors: 1) GH deficiency in 42 cases as assessed by the arginine insulin tolerance test. 2) Spinal lesions due to irradiation, causing early growth retardation and a reduced trunk length in most of these children. The response to hGH treatment (10 mg/kg/yr) was not sufficient in this group of patients.
D001827:Body Height; D002490:Central Nervous System / Q000528:radiation effects*; D002528:Cerebellar Neoplasms / Q000532:radiotherapy*; D002648:Child; D006130:Growth Disorders / Q000209:etiology*; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008527:Medulloblastoma / Q000532:radiotherapy*; D012189:Retrospective Studies
D013006:Growth Hormone
Croissance staturale après irradiation du système nerveux central pour médulloblastome de la fosse postérieure. Analyse rétrospective de 45 observations.