[Effect of a membrane modulator from the 3-hydroxypyridine class on the pharmacological activity of a number of psychotropic preparations].
Influence of membrane-active derivative of 3-hydroxypyridine on psychotropic activity of drugs with different chemical structure and type of action--neuroleptics (chlorpromazine, trifluoperazine, reserpine), tranquillizers (diazepam, phenazepam, calcium valproate), hypnotics (Hexobarbital), was studied in the experiment on animals. Application of psychotropic drugs after preliminary 3-hydroxypyridine administration was established to induce a considerable increase of their pharmacological activity--anxiolytic, sedative and hypnotic. Mechanism of action of 3-hydroxypyridine on pharmacological effects of psychotropic drugs is supposed to be caused by its membrane-modulating action, precisely by its influence on physical-chemical properties and phospholipid composition of synaptic biomembranes.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003220:Conflict, Psychological; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D000975:Antioxidants; D011619:Psychotropic Drugs; D011725:Pyridines; C023500:3-hydroxypyridine
Vliianie membranomoduliatora iz klassa 3-oksipiridina na farmakologicheskuiu aktivnost' riada psikhotropnykh preparatov.