Lactate transport through the blood-retinal and the blood-brain barrier in rats.
The retinal and brain uptake index method was utilized in a study on rats to evaluate the existence of transport systems for lactate in the blood-retinal and the blood-brain barrier, respectively. For both retina and brain a saturable, pH-dependent uptake of L-lactate was observed. The uptake could also be inhibited by pyruvate and 3-hydroxybutyrate. It is concluded that lactate is transported through the blood-retinal and the blood-brain barriers by similar carrier-mediated transport systems with affinity also to other monocarboxylic acids, such as pyruvate, and to the ketone body 3-hydroxybutyrate. The pH-dependence of the lactate transport suggests that co-transport of H+ ions or counter-transport of OH- ions takes place.
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D006863:Hydrogen-Ion Concentration; D006885:Hydroxybutyrates / Q000494:pharmacology; D007773:Lactates / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D011773:Pyruvates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012171:Retinal Vessels / Q000378:metabolism*
D006885:Hydroxybutyrates; D007773:Lactates; D011773:Pyruvates; D020155:3-Hydroxybutyric Acid