Simultaneous recording of pattern electroretinogram and visual evoked responses in neuro-ophthalmologic disorders.
Simultaneous pattern electroretinograms (P-ERG) and pattern visual evoked potentials (P-VEP) to transient and steady-state checkerboard pattern reversal were recorded in 52 normal volunteers. Twenty-seven patients were also studied. Three patterns of abnormalities emerged. Pattern 1 with prolonged P-ERG, prolonged P-VEP, and normal retino-cortical time (RCT) was found exclusively in early maculopathies. Pattern 2 with normal P-ERG, prolonged P-VEP, and prolonged RCT was found in optic nerve lesions without optic atrophy, probably indicating the presence of a demyelinating lesion of the optic nerve. Pattern 3, with very small or absent P-ERG and P-VEP, was observed in both maculopathies and optic atrophies.
D000328:Adult; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000503:physiopathology; D003937:Diagnosis, Differential; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D005556:Form Perception / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D008266:Macula Lutea / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology; D009896:Optic Atrophy / Q000175:diagnosis / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D014792:Visual Acuity; D058609:Visual Field Tests