[Comparative study of the indices of the antidepressive activity of potassium orotate and piracetam].
It has been established in mouse experiments that potassium orotate (100 mg/kg) and piracetam (500 mg/kg) given in chronic oral doses have an antidepressant activity according to the "behavioral despair" test. It has been demonstrated that antidepressant activity of potassium orotate (20 and 50 mg/kg) and piracetam (50 and 100 mg/kg) is associated with a psychostimulant effect.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009963:Orotic Acid / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology; D011760:Pyrrolidinones / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D012149:Restraint, Physical; D013558:Sydnones / Q000494:pharmacology; D013997:Time Factors
D000928:Antidepressive Agents; D011619:Psychotropic Drugs; D011760:Pyrrolidinones; D013558:Sydnones; D000639:Amitriptyline; D009963:Orotic Acid; D012110:Reserpine; C009257:sidnocarb; D010889:Piracetam
Sravnitel'noe issledovanie nekotorykh pokazateleĭ antidepressivnoĭ aktivnosti kaliia orotata i piratsetama.