[Specific contribution of dietary polyunsaturated fatty acids of the n-3 series to the development of nervous system membranes].
Polyunsaturated fatty acids, especially omega 3 fatty acids, made a specific contribution to the nervous tissue. Retarded intrauterine growth caused a twofold reduction in the oligodendrocyte ratio of omega 3/omega 6 while the same ratio increased by more than twofold in the neurons. A fatty acid-poor diet composed of arachid or sunflower oil dramatically altered the composition of cells and subcellular particles when compared with a soya or rapeseed oil diet containing omega 3 fatty acids; phosphatidylethanolamine was particularly affected. Nerve cell culture showed that brain essential fatty acids are probably docosahexaenoic acid and arachidonic acid.
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000196:embryology*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009836:Oligodendroglia / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008563:Membrane Lipids; D010743:Phospholipids
Importance spécifique des acides gras polyinsaturés alimentaires de la série n-3 dans l'élaboration des membranes du système nerveux.