The effect of carbon black ingestion on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats and mice.
The possible co-carcinogenic effect of ingestion of industrial carbon black was examined in female Sprague-Dawley rats and female CF1 mice treated with 1,2-dimethylhydrazine (DMH) to induce adenocarcinomas of the colon. Carbon black was added to the diet at 2.05 g/kg feed and fed for 52 weeks. No differences (P greater than 0.05) in tumor incidences were seen in rats or mice. Simultaneous 2-year feeding experiments with carbon black alone showed no increase in the development of spontaneous tumors. These findings are consistent with the belief that carbon blacks are ineffective as carcinogens because of their adsorptive properties.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002244:Carbon / Q000633:toxicity*; D003043:Cocarcinogenesis; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004127:Dimethylhydrazines; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D002244:Carbon; D019813:1,2-Dimethylhydrazine