Kerosene aerosol induces guinea-pig airway hyperreactivity to acetylcholine.
Kerosene aerosol (32.5 mg/l; 20 min), when administered to guinea pigs 1 h before exposure to acetylcholine (Ach), induced potentiation of cumulative dose-response curve of this agonist on isolated tracheal strips as well as a decrease of the lethal doses of Ach. This enhanced response was absent or greatly reduced when kerosene aerosol was administered to guinea pigs 24 h previously or just before Ach challenge. This airway hyperreactivity was also lacking when carbachol or histamine were used as spasmogens instead of Ach. Possible explanations of these results are discussed.
D000109:Acetylcholine / Q000494:pharmacology*; D000336:Aerosols; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007648:Kerosene / Q000633:toxicity*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010578:Petroleum / Q000633:toxicity*; D013997:Time Factors; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D000336:Aerosols; D007648:Kerosene; D010578:Petroleum; D006632:Histamine; D002217:Carbachol; D000109:Acetylcholine