Squamous cell carcinoma of the extremities.
Between January 1976 and January 1983, 37 cases of squamous cell carcinoma of the extremities have been treated at the King Faisal Specialist Hospital and Research Centre by the authors. Each case has arisen in an area of preexisting scar or sinus. Twenty-nine cases were treated by definitive amputation, with 2 local recurrences and 12 nodal metastases. Seven cases had local excision, with three local recurrences and two nodal metastases. Recurrence rate was highest in Grade II and Grade III lesions, and 11 of 15 cases with Grade II disease had metastases to the regional lymph nodes an average of 5 months after surgery. With Grade I disease patients, 4 of 15 had nodal metastases an average of 5 months after surgery. Prophylactic regional nodal irradiation or node dissection was performed in seven cases. None of these cases have shown nodal metastases at an average of 24 months following definitive surgery and radiation. Routine prophylactic regional node irradiation is recommended in all cases of peripheral squamous cell carcinoma.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D002056:Burns / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000532:radiotherapy / Q000601:surgery; D002921:Cicatrix / Q000150:complications; D005121:Extremities / Q000293:injuries*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D010019:Osteomyelitis / Q000150:complications; D019736:Prostheses and Implants / Q000009:adverse effects; D012529:Saudi Arabia; D014456:Ulcer / Q000150:complications