Pharmacokinetics of nifedipine.
The pharmacokinetics of a slow-release formulation of nifedipine were studied following oral administration of a single 20 mg tablet in nine young male volunteers. Blood samples were collected and nifedipine concentrations analysed by gas liquid chromatography. Compared to conventional nifedipine, there was a delay in peak concentrations and a much smaller range of peak plasma levels. The smaller interindividual variability of plasma drug levels may be useful in the treatment of hypertension.
D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage / Q000378:metabolism*
D009543:Nifedipine