Effect of diet on spontaneous disease in the inbred mouse strain C57B1/10J.
The incidence of spontaneous disease in an inbred mouse strain, C57B1/10J, is compared in control groups from 5 carcinogenicity studies performed in the same laboratory between 1973 and 1980; the mice were bred at 2 laboratories, and 3 different diets were used. Significant differences were found in the incidence of total tumours and in many individual tumour types. The incidence of major non-neoplastic diseases also varied markedly. The effects of diet on spontaneous disease are now well-established. The results support this contention and demonstrate that diet may override the genetic characteristics of an inbred strain.
D000821:Animal Feed / Q000032:analysis; D000818:Animals; D004032:Diet; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary; D012376:Rodent Diseases / Q000453:epidemiology*