Is phase variation in Bordetella caused by mutation and selection?
In vitro growth conditions of Bordetella bronchiseptica led to an enrichment of phase variants. The frequency of phase variation was about 10(-6) per cell per generation. Therefore phase variation in Bordetella may result from a random mutation in a controlling region, followed by selection.
D000262:Adenylyl Cyclases / Q000032:analysis; D001884:Bordetella / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development; D002453:Cell Cycle; D014644:Genetic Variation; D009154:Mutation; D012641:Selection, Genetic
D000262:Adenylyl Cyclases