[Specificity and sensitivity of lipoprotein lipids in normal persons and cardiovascular patients].
The amplitude of the determination of lipoprotein lipids and cholesterol quotients for the estimation of the atherogenic risk and the risk of myocardial infarction was investigated on 24 normal persons, 21 patients with overcome myocardial infarction, 47 hypertensives and 20 obese patients. Under the methodical conditions the quotient total cholesterol/HDL cholesterol showed the best separating power between normal and atherogenically endangered (increased risk greater than 6.0: specifity 92%, sensitivity 67% for patients with infarction, 57% for hypertensives, and 45% for obese persons). LDL-cholesterol, calculatorily established by means of Friedewald's formula, and the quotient LDL/HDL-cholesterol with circa the same specifity for the groups of patients had a clearly lower sensitivity (patients with infarction 38%, hypertensives 50%, obese 21%). The lower sensitivity of the quotient LDL-/HDL-cholesterol is traced back to methodical insufficiencies (calculation of the LDL-cholesterol from three lipid values). The determination of the quotient total cholesterol/HDL-cholesterol for the description of the atherogenic and coronary risk respectively, is recommended for practice.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D009765:Obesity / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol
Spezifität und Sensitivität von Lipoproteinlipiden bei Normalpersonen und Herz-Kreislaufpatienten.