c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.
The cellular proto-oncogene c-Ha-ras-1 undergoes up to 4-fold amplification during the limited replicative life span of normal human diploid fibroblasts in vitro. Levels of c-Ha-ras-1 messenger RNA and its p21 protein product are correspondingly elevated. Cellular proto-oncogene amplification and overexpression, although frequently associated with tumorigenesis, may thus occur during normal cellular growth.
D002453:Cell Cycle; D002455:Cell Division; D002470:Cell Survival; D002478:Cells, Cultured; D004247:DNA / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005784:Gene Amplification; D006801:Humans; D009154:Mutation; D009857:Oncogenes; D011506:Proteins / Q000378:metabolism; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000378:metabolism
C000715470:MAS1 protein, human; D011506:Proteins; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D004247:DNA