Study of hepatic binding protein activity in jejuno-ileal by-passed rat hepatocytes.
The kinetic constants of internalization of asialoorosomucoid were determined for normal and jejuno-ileal by-passed rat hepatocytes. In by-passed rats the maximum velocity of asialoorosomucoid internalization is decreased 3-fold, without any modification of apparant constant of internalization. Moreover, the rate constant of internalization was the same in the two groups of rats. These data suggest that the process of asialoorosomucoid internalization is not altered in by-passed hepatocytes and that the decrease of maximal velocity is only due to a decrease of total uptake receptor number.
D000818:Animals; D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D002352:Carrier Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D007082:Ileum / Q000502:physiology; D007583:Jejunum / Q000502:physiology; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D002352:Carrier Proteins; D009961:Orosomucoid; C017030:asialoorosomucoid; C027122:hepatic sialoglycoprotein receptor