[Multicomponent detoxifying system in albino rat liver].
Experiments on white rats were made to study the system of xenobiotic detoxifying. The measurements were taken of the content of cytochromes P-450 and b5, of the activity of NADP X H- and NAD X H-dependent monoxygenases, of the levels of microsomal albumin, thiol groups, and of the mass index of the liver in intact animals and in those injected with phenobarbital and SKF-525A. The most informative indicators determining the detoxifying system functioning were identified by factor analysis. Correlations were also established between components of the system. It turned out that transformation of the correlations in question was the result of phenobarbital and SKF-525A injection. The authors discuss the importance of the character and degree of this transformation for evaluation of the tension of the xenobiotic detoxifying system functioning and measures aimed at ensuring its reliability under the effect of harmful environmental factors.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats
D003573:Cytochrome b Group; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D010634:Phenobarbital
Issledovanie mnogokomponentnoĭ sistemy detoksikatsii v pecheni belykh krys.