Effect of a small dose of droperidol on nausea, vomiting and recovery after outpatient enflurane anaesthesia.
Young, healthy outpatients (100) undergoing restorative dentistry and/or oral surgery under enfluranenitrous oxide-oxygen anaesthesia were given 0.014 mg/kg of droperidol or a saline placebo i.v. in a double-blind random fashion 5 min after induction of anaesthesia to prevent postoperative nausea and vomiting. Overall, less patients given droperidol were nauseated (18%) or vomited (7%) in comparison with patients given saline (27% and 11%, respectively). During the first postoperative hour, 4% of patients given droperidol were nauseated and 2% vomited, whereas 16% of patients given saline were nauseated and 6% vomited. Four patients given saline were not discharged from the clinic 1 h after anaesthesia owing to prolonged nausea and vomiting. The time elapsed until the patients were oriented as to time and place after cessation of enflurane and nitrous oxide administration was similar in both groups (mean +/- s.d., 13.5 +/- 4.7 min). Thirty minutes after anaesthesia, the ability to walk on a straight line was significantly (P less than 0.001) worse in patients given droperidol as compared to patients given saline. After 60 min, only one patient given droperidol and four patients who received saline and vomited took side steps or were unable to walk. Psychomotor performance was significantly (P less than 0.05) better in a perceptual speed test both 30 and 60 min after anaesthesia in patients receiving saline as compared to those given droperidol. It is concluded that although droperidol is a less effective antiemetic after outpatient than after inpatient enflurane anaesthesia, small doses of droperidol may be used for outpatients prone to vomiting to prevent delayed discharge from the clinic due to prolonged vomiting.
D000328:Adult; D000556:Ambulatory Surgical Procedures; D000770:Anesthesia, Endotracheal; D003793:Dental Restoration, Permanent; D004329:Droperidol / Q000627:therapeutic use*; D004737:Enflurane / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D009055:Mouth / Q000601:surgery; D009325:Nausea / Q000139:chemically induced* / Q000517:prevention & control; D014839:Vomiting / Q000139:chemically induced* / Q000517:prevention & control
D004737:Enflurane; D004329:Droperidol