Immunization of pigs against Ascaris suum by sequential experimental infections terminated with fenbendazole during larval migration.
Three experimental infections of weaning pigs with 2000 embryonated Ascaris suum eggs each, 11 days apart, followed each time by fenbendazole treatment, produced a significant host response when compared with similar infected or uninfected control pigs as assessed by response to a subsequent challenge with 100 embryonated A. suum eggs. The response elicited from pigs treated with fenbendazole on either 2, 3, and 4 days or, 6, 7, and 8 days after each experimental infection was expressed as a reduction in the number of pigs with A. suum, in the number of worms per pig, in the weight of male and female worms, and in the length of male and female worms. No differences in average daily weight gain, feed-conversion efficiency or histology of lungs and liver were noted among the 4 treatment groups.
D000818:Animals; D001196:Ascariasis / Q000469:parasitology / Q000628:therapy / Q000662:veterinary*; D001200:Ascaris / Q000187:drug effects / Q000502:physiology; D001562:Benzimidazoles / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005273:Fenbendazole / Q000494:pharmacology / Q000627:therapeutic use*; D007114:Immunization / Q000662:veterinary*; D007814:Larva / Q000187:drug effects; D008297:Male; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology / Q000628:therapy*
D001562:Benzimidazoles; D005273:Fenbendazole