Histamine and collagen levels in the lathyritic chick embryos after administration of 48/80.
The studies were undertaken to investigate the influence of compound 48/80 on histamine (Hi) and collagen levels of chick embryos after administration of lathyrogen factor, beta-aminopropionitrile (BAPN). Hi and soluble collagen levels in bones (tibia and femur) and skin were significantly higher in the embryos treated with BAPN. Compound 48/80 administered together with BAPN lowered Hi and soluble collagen in the bones and skin as compared with the embryos treated with BAPN alone. Both, in the skin and bones, 48/80 was found to be a protective factor against the changes in biosynthesis of collagen.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001842:Bone and Bones / Q000032:analysis; D002642:Chick Embryo; D003094:Collagen / Q000032:analysis*; D006632:Histamine / Q000032:analysis*; D007842:Lathyrism / Q000378:metabolism; D012867:Skin / Q000032:analysis; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D000629:Aminopropionitrile; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D003094:Collagen