Strain comparison of synaptic density in hippocampal CA1 of aged rats.
Synaptic density in hippocampal CA1 stratum radiatum was studied in two different strains of rat at 3 and 24-28 months of age. Neither Fischer 344 nor Sprague-Dawley rodents showed any age-related loss of synapses. These data support the contention that synapse loss with age is not a generalized phenomenon in the mammalian CNS.
D000375:Aging; D000818:Animals; D006624:Hippocampus / Q000648:ultrastructure*; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D013569:Synapses / Q000648:ultrastructure*