Cimetidine and hepatic blood flow in polytrauma patients.
Recent reports suggest that cimetidine acutely reduces liver blood flow in normal healthy subjects. To determine whether this finding is applicable to critically ill patients, we studied nine polytrauma patients admitted to a surgical ICU. All patients were being monitored with pulmonary artery catheters; all were stable with normal liver function. Liver blood flow was estimated by indocyanine green clearance, before and after administration of a single dose of 600 mg cimetidine. Hemodynamic variables were measured at the same times. Cimetidine did not significantly alter either hepatic blood flow or cardiovascular status in these critically ill patients.
D000328:Adult; D000368:Aged; D002302:Cardiac Output / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism; D007275:Injections, Intravenous; D008102:Liver Circulation / Q000187:drug effects*; D008875:Middle Aged; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014947:Wounds and Injuries / Q000503:physiopathology*
D002927:Cimetidine; D007208:Indocyanine Green