The pharmacokinetic behaviour of chloramphenicol in liver-damaged mini-pigs.
Using mini-pigs with an indwelling vascular catheter, the pharmacokinetics of chloramphenicol were investigated in healthy and liver-damaged animals. The liver damage was induced by thioacetamide and its degree was estimated by measuring the level of bile acids in serum. Employing a two-compartment open model for analysing the time-dependent course of the chloramphenicol concentration in serum, it was shown that in liver-damaged animals the elimination half-time was almost doubled as a result of reduced total body clearance. The consequences of liver damage for withdrawal times and dosage schedules are discussed.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D002701:Chloramphenicol / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008107:Liver Diseases / Q000378:metabolism*; D008297:Male; D013552:Swine; D013556:Swine, Miniature / Q000378:metabolism*; D013853:Thioacetamide
D013853:Thioacetamide; D002701:Chloramphenicol