[Studies on the mechanism of the estrogen action in human breast cancer].
Only some 50% of estrogen receptor positive breast cancer patients respond to hormone therapy. It is possible that the mechanism of the estrogen action is disturbed in malignant cells. In order to determine which steps of the mechanism are disturbed, cytoplasmic estrogen and progesterone receptor and nuclear estrogen receptor were studied in 217 cases of human breast cancer. Thirty breast cancer tumors were examined for nuclear translocation of estradiol in vitro. The assessment of the translocation experiments showed good correlation to the ERN status by the DCC method. This experiment was considered to be a simple method of assessment of translocative ability.
D001943:Breast Neoplasms / Q000032:analysis*; D002467:Cell Nucleus / Q000032:analysis; D004967:Estrogens / Q000502:physiology*; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis
D004967:Estrogens; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone