Basal lamina at the site of spinal cord injury in normal, immunotolerant and immunosuppressed rats.
The cut ends of a rat spinal cord are capped with basal lamina (BL) within 20 days. This BL may block regenerating axons. BL at the transection site in rats made immunologically unresponsive to central nervous system antigens is not significantly different from that of control rats, but rats treated with cyclophosphamide show a less complete BL cap during the first 25 days. This may account for the increased axonal regeneration found in cyclophosphamide-treated rats.
D000818:Animals; D002921:Cicatrix; D003520:Cyclophosphamide / Q000627:therapeutic use*; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D051381:Rats; D012038:Regeneration; D013116:Spinal Cord / Q000473:pathology*; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*
D003520:Cyclophosphamide