Increased chromosomal aberrations in first metaphases of cells isolated from the kidneys of aged mice.
Chromosomal aberrations were scored in the first metaphases of cells isolated from the kidneys of young (8 months old) and aged (40 months old) CB6F1 mice. There was a sixfold increase in the frequency of such aberrations in metaphases from old mice as compared with young mice.
D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D007621:Karyotyping; D007668:Kidney / Q000166:cytology*; D008297:Male; D008677:Metaphase; D051379:Mice; D008940:Mitotic Index