The effects of lanthanum chloride on pregnancy in mice and on preimplantation mouse embryos in vitro.
A single intraperitoneal injection of 10(-6.5) mol lanthanum chloride/g body wt (44 mg metal/kg body wt) into pregnant mice reduced the number of successful pregnancies and the average litter size. The most susceptible periods of pregnancy were peri-implantation (days 4 and 6) and near-term period (days 14 and 16). Injection of lanthanum during the peri-implantation period resulted in a cessation of pregnancy in 24-43% of females, and injection during near-term period produced the cessation of pregnancy in 36-46% of the females. The average litter size after injection of lanthanum during peri-implantation or near-term periods was reduced to about 75% of the average litter size in the control animals. No external malformations were observed among fetuses. Paradoxically, the exposure of 1-cell stage embryos to 10(-3.0) M and 10(-3.5) M lanthanum chloride in vitro resulted in a significant improvement of the proportion of embryos developing into blastocysts.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D010064:Embryo Implantation / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D066298:In Vitro Techniques; D007811:Lanthanum / Q000633:toxicity*; D008098:Litter Size / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
C028521:lanthanum chloride; D007811:Lanthanum