[Persistent influenza virus infection. Molecular genetic characteristics of ts mutants selected during persistence].
Properties of ts mutants isolated from systems of persistent influenza infection formed in MDCK cell culture by A/Victoria/35/72 virus were studied. The ts mutants isolated at later intervals of persistent infection (158 days) were characterized by thermolability of hemagglutinin and neuraminidase, changes in the EP mobility of HA2 polypeptide, decrease in the molecular weight of this polypeptide, appearance of multiple ts mutations in genes 3, 5, 6, 7, and 8, coding for P2, NP, NA, M, and NS proteins, respectively.
D000818:Animals; D003673:Defective Viruses / Q000235:genetics; D005814:Genes, Viral; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000032:analysis / Q000235:genetics* / Q000472:pathogenicity; D009154:Mutation; D009439:Neuraminidase / Q000032:analysis; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D010455:Peptides / Q000032:analysis; D011995:Recombination, Genetic; D012641:Selection, Genetic; D013696:Temperature; D014776:Virus Cultivation
D006389:Hemagglutinins, Viral; D010455:Peptides; D009439:Neuraminidase
Persistentnaia infektsiia virusa grippa. Molekuliarno-geneticheskaia kharakteristika ts-mutantov, selektsioniruiushchikhsia v protsesse persistentsii.