Alpha-particle track autoradiographic study of the distribution of a [211At]-astatinated drug in normal tissues of the mouse.
The microscopic distribution of the potential endoradiotherapeutic drug, 6-[211At]-astato-2-methyl-1,4- naphthoquinol bis (diphosphate salt) in normal tissues of the mouse has been studied by alpha-particle track autoradiography. The uptake into critical radiosensitive tissues, especially bone marrow, colon and lung, was low.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism; D001246:Astatine / Q000378:metabolism*; D001345:Autoradiography; D001853:Bone Marrow / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D014018:Tissue Distribution; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000378:metabolism; D024483:Vitamin K 3 / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; D014812:Vitamin K; D024483:Vitamin K 3; C033669:astato-2-methyl-1,4-naphthoquinol diphosphate; D001246:Astatine