[Effect of propranolol and alcohol on hemodynamics and fatality in the rat].
In rats, diastolic and systolic pressure-volume correlations of the intact heart in situ were recorded under control conditions and after various amounts of propranolol and ethanol given intravenously. Besides the cardio-depressant effect of propranolol, there is an additional dose-dependent effect caused by ethanol. The administration of propranolol or ethanol alone, even in high doses, causes no mortality; the combination of both drugs even in low doses is associated with a lethality of about 40%. Only few comparable clinical findings have been presented.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats
D000431:Ethanol; D011433:Propranolol
Wirkung von Propranolol und Alkohol auf Hämodynamik und Letalität bei der Ratte.