Biotransformation of progesterone to 14 alpha-hydroxypregna-1,4-diene-3,20-dione, a novel fungal metabolite, by Colletotrichum antirrhini.
The fermentation of progesterone by Colletotrichum antirrhini SC 2144 was examined. Instead of 15 alpha-hydroxyprogesterone, the reported product, this fungus converted progesterone to androst-4-ene-3,17-dione, androsta-1,4-diene-3,17-dione, 14 alpha-hydroxyandrosta-1,4-diene-3,17-dione, 11 alpha-hydroxypregn-4-ene-3,20-dione, 14 alpha-hydroxypregn-4-ene-3,20-dione, and a hitherto undescribed compound, 14 alpha-hydroxypregna-1,4-diene-3,20-dione.
D005285:Fermentation; D006908:Hydroxyprogesterones / Q000378:metabolism*; D003904:Mitosporic Fungi / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*
D006908:Hydroxyprogesterones; D011374:Progesterone; C045403:14-hydroxypregna-1,4-diene-3,20-dione