Opiate regulation of mesolimbic serotonin release: in vivo semiderivative electrochemical analyses.
The effect of a pharmacologically effective dose of d-morphine sulfate on serotonin release from nucleus accumbens of male, Sprague-Dawley rats was studied. In vivo electrochemical evidence showed that the reference exogenous opiate, morphine, after intraperitoneal administration, significantly increased basal nucleus accumbens serotonin release over control values. These data show a mesolimbic opiate-serotonergic interaction in rat brain.
D000818:Animals; D004563:Electrochemistry; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical
D012701:Serotonin; D009020:Morphine