Multiple organ failure resulting from intravenous abuse of methylphenidate hydrochloride.
A 32-year-old woman who abused methylphenidate hydrochloride developed complications including hepatic, renal, pancreatic, pulmonary, and CNS toxicities. These were manifested by abnormal liver function enzymes, poor urine output, hypotension, tachypnea, tachycardia, abnormal blood gases, rising serum BUN and creatinine, and hyperactive deep-tendon reflexes. All were reversible with medication withdrawal and supportive therapy. Toxicities of this medication and their implications are discussed.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D004298:Dopamine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000139:chemically induced; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008774:Methylphenidate; D010195:Pancreatitis / Q000139:chemically induced; D012965:Sodium Chloride / Q000627:therapeutic use; D019966:Substance-Related Disorders / Q000503:physiopathology*
D008774:Methylphenidate; D012965:Sodium Chloride; D004298:Dopamine