[Residual DNA damages in irradiated HeLa cells].
A possibility to detect the low level residual DNA damages was undertaken in HeLa cells during a long time after irradiation. The mixture of two inhibitors of replicative and reparative syntheses (hydroxyurea and beta-arabinosylcytosine) was added to the HeLa monolayer culture cells 6--24 hours after irradiation, when the potentially lethal damages was removed. A decrease in cell survival was shown. These data suggest that a certain amount of damages may still remain in DNA of irradiated cells.
D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004261:DNA Replication / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D013997:Time Factors
D003561:Cytarabine; D004247:DNA; D006918:Hydroxyurea
Ostatochnye povrezhdeniia DNK v obluchennykh kletkakh HeLa.