The effect of bilirubin on the phagocytic activity of mouse peripheral granulocytes and monocytes in vivo.
Using an in vitro phagocytic assay with synthetic 2-hydroxyethylmethacrylate copolymer particles, the phagocytic activity of leukocytes of bilirubin-treated mice (85 and 170 mumol/L in 0.5 mL intraperitoneally) was studied. Bilirubin treatment significantly stimulated the phagocytosis of both peripheral blood granulocytes and monocytes; the increase of phagocytosis persisted for 6 h after bilirubin injection. The potential immunostimulating and/or immunotoxic effect of bilirubin is discussed.
D000818:Animals; D001663:Bilirubin / Q000494:pharmacology*; D004731:Endotoxins / Q000097:blood; D005260:Female; D006098:Granulocytes / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000187:drug effects* / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects*; D012709:Serum Albumin / Q000494:pharmacology; D013997:Time Factors
D004731:Endotoxins; D012709:Serum Albumin; D001663:Bilirubin