The effect of praziquantel, an antihelminthicum, on the peptidergic nervous system of the tapeworm Diphyllobothrium dendriticum.
The effect of the antihelminthic substance Praziquantel on the peptidergic nervous system in the adult gull-tapeworm Diphyllobothrium dendriticum was tested. As well as increasing muscle contraction the drug provoked a fall in the amount and size of the peptidergic nerve terminals in the subtegumental region. The number of small clear vesicles in the terminals also fell.
D000818:Animals; D004170:Diphyllobothrium / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005399:Fishes / Q000469:parasitology; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009420:Nervous System / Q000187:drug effects*; D011223:Praziquantel / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007546:Isoquinolines; D009419:Nerve Tissue Proteins; D011223:Praziquantel