Effects on upper gastrointestinal mucosa of three delivery systems of potassium as supplement to frusemide administration.
Thirty healthy volunteers were recruited into a study to determine the effects on the gastrointestinal mucosa of 3 different delivery systems of oral potassium supplementation associated with diuretic therapy (Diumide-K ContinusR tablets, Napp; Lasikal tablets, Hoechst; Lasix and Slow-KR tablets, Hoechst, Ciba). The volunteers were gastroscoped initially and after one week of treatment with one of the three therapies. There was a 60% incidence of erosions in the Lasix + Slow-K group, a 40% incidence in the Lasikal group, but no erosions in the group receiving Diumide-K Continus tablets. It is therefore concluded that Diumide-K Continus tablets incorporate the potassium in a delivery system which is unlikely to cause disruption to the gastrointestinal mucosa.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003692:Delayed-Action Preparations; D004232:Diuretics / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D005753:Gastric Mucosa / Q000187:drug effects*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011189:Potassium Chloride / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D004232:Diuretics; D004338:Drug Combinations; D011189:Potassium Chloride; D005665:Furosemide; C036072:Diumide-K continus