Naturally-occurring pituitary growth hormone is phosphorylated.
The results of this communication show that ovine growth hormone (oGH) contains organically-bound phosphorous. The phosphorous content of growth hormone, lot S-11, is 1:3 (mol/mol) and that of lot S-12 is 1:6 (mol/mol). Results of 31P NMR studies suggest that the phosphorous exists in two chemical forms: as a monophosphoryl ester and as a phosphodiester. Evidence is provided which demonstrates that growth hormone can be phosphorylated in vitro with the catalytic subunit of protein kinase.
D000818:Animals; D013006:Growth Hormone / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D010758:Phosphorus / Q000032:analysis; D010766:Phosphorylation; D010902:Pituitary Gland / Q000032:analysis*; D012756:Sheep
D010758:Phosphorus; D013006:Growth Hormone