Pathophysiological studies in hypercalciuric and normocalciuric stone formers.
This study has been carried out in order to investigate the effects of a standard oral calcium load in 18 hypercalciuric and 18 normocalciuric recurrent stone formers. Following oral loading there was not a significant difference in the two groups studied, as far as serum calcium increment was concerned; however, urinary calcium excretion was significantly greater in hypercalciuric stone formers. The results obtained, although they do not exclude the presence of intestinal calcium hyperabsorption, seem to demonstrate the existence of a diminution of renal tubular calcium reabsorption in patients with idiopathic hypercalciuria.
D000284:Administration, Oral; D000328:Adult; D002118:Calcium / Q000008:administration & dosage / Q000652:urine*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000652:urine*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000652:urine
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium