Lateral hypothalamic self-stimulation persists in rats after destruction of lateral hypothalamic neurons by kainic acid or ibotenic acid.
Bilateral injections of 1 microgram/microliter of kainic or ibotenic acid into the lateral hypothalamus (LH) of rats destroyed most of the cells in the LH. This treatment did not prevent electrical self-stimulation from electrodes placed in the LH, indicating that intrinsic neurons of the LH alone are not crucial elements of the neural system that mediates reinforcing hypothalamic stimulation.
D000818:Animals; D005260:Female; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000502:physiology*; D007051:Ibotenic Acid / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects / Q000502:physiology*
D010080:Oxazoles; D011759:Pyrrolidines; D007051:Ibotenic Acid; D007608:Kainic Acid