The time course of sebum secretion in the guinea-pig.
The time course of sebum secretion in the guinea-pig (Cavia porcellus) was determined by intradermal injection of [1-14C]acetate followed by daily collection of the skin surface lipids at the injection site. The skin surface lipids reached a peak of radioactivity at 5-6 days, indicating that this is the time which elapses between the synthesis of sebum and the surface excretion of the sebaceous lipids. Of the three major skin surface lipid components, the sterol esters (25%) and the wax diesters (25%) showed similar peaks of radioactivity after labelling, but the glycerol ether diesters (30%) showed no radioactivity at any time, suggesting that this lipid is not produced in the skin.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007700:Kinetics; D050356:Lipid Metabolism; D008297:Male; D012629:Sebum / Q000187:drug effects / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
D000085:Acetates