Strain-dependent variations in the number of forebrain cholinergic neurons.
The morphological organization of putatively cholinergic neurons was studied in the forebrain of two inbred mouse strains (C57BL/6 and DBA/2) by means of acetylcholinesterase pharmacohistochemistry. In both strains, putatively cholinergic perikarya were seen in the caudato-putamen, medial septum, diagonal band, and basal nucleus of Meynert: in all these regions, their distribution was similar in both strains, but their density was significantly higher (from 20 to 32%) in DBA/2 mice. The present data demonstrate the existence of genetically determined differences in the organization of forebrain cholinergic systems.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002452:Cell Count; D002799:Cholinergic Fibers; D004027:Diencephalon / Q000166:cytology* / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013045:Species Specificity; D013687:Telencephalon / Q000166:cytology* / Q000201:enzymology
D000110:Acetylcholinesterase