Changes in the size of isolated chromaffin granules in ATP-evoked catecholamine release.
The average size of chromaffin granules isolated from bovine adrenal medullae was analyzed by a quasi-elastic laser light scattering method. The granule diameter increased by a factor of 1.3 by addition of Mg-ATP in the medium. The ATP effect was completely suppressed in the presence of an anion transport blocker (SITS), and partly depressed by a proton transport blocker (DCCD).
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002837:Chromaffin Granules / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D002838:Chromaffin System / Q000648:ultrastructure*; D008027:Light; D012542:Scattering, Radiation
D002395:Catecholamines; D000255:Adenosine Triphosphate