Still's disease and the virus-associated haemophagocytic syndrome.
A 15-year-old male developed features of Still's disease. He was treated, with incomplete response, with aspirin and corticosteroids. Some 10 months after the onset he contracted chickenpox and became gravely ill. A diagnosis of histiocytic medullary reticulosis was made because erythrophagocytic histiocytes were detected in marrow aspirate films. Necropsy studies showed systemic infiltration by benign-appearing histiocytes and led to the final diagnosis of the virus-associated haemophagocytic syndrome due to varicella-zoster infection in an immunocompromised patient.
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002644:Chickenpox / Q000150:complications* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D013577:Syndrome