Cerebrospinal fluid leucine-enkephalin-like levels in febrile convulsions.
Enkephalin levels were measured in the cerebrospinal fluid (CSF) of 17 patients with febrile convulsions and 11 control patients without a history of pain or convulsive disorders. Enkephalins were extracted from CSF by adsorption with synthetic resin XAD-2 eluted with methanol, and assayed using the radioreceptor assay (RRA). Results were expressed as Leucine-Enkephalin (Leu-E) equivalents. Enkephalin levels in CSF were 2.27 +/- 0.42 pmol/ml (mean +/- SE) in the convulsion group and the 4.8 +/- 0.8 pmol/ml (mean +/- SE) in the control group. Statistical comparison in both groups shows significant differences (p less than 0.001). These results suggest a correlation between convulsions and enkephalin levels in CSF.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D004743:Enkephalin, Leucine / Q000134:cerebrospinal fluid*; D004745:Enkephalins / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009294:Narcotics; D012640:Seizures / Q000139:chemically induced; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid*
D004745:Enkephalins; D009294:Narcotics; D004743:Enkephalin, Leucine