Abnormal collagen fibrillogenesis in epiphyseal cartilage of CMD (cartilage matrix deficiency) mouse.
Light and electron microscopic observations on the structure of epiphyseal cartilages in the cmd/cmd mice, which had genetically failed to synthesize cartilage-characteristic proteoglycan but were normal in type II collagen synthesis, showed apparent abnormalities of collagen fibrils: e.g. increase in the diameter, appearance of periodic banding patterns and bundle-formation of collagen fibrils. These findings suggest that cartilage-characteristic proteoglycan normally limits the lateral growth of collagen fibrils and affects collagen fibrillogenesis in vivo.
D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D004392:Dwarfism / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005109:Extracellular Matrix / Q000378:metabolism; D006132:Growth Plate / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D051379:Mice; D008817:Mice, Mutant Strains / Q000378:metabolism*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011509:Proteoglycans / Q000378:metabolism; D012376:Rodent Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D011509:Proteoglycans; D003094:Collagen