The kinetics of unmatched and HLA-matched 111in-labelled homologous platelets in recipients with chronic marrow hypoplasia and anti-platelet immunity.
The kinetics of homologous platelets, labelled in plasma with 111In-tropolonate, have been studied in five recipients with chronic marrow hypoplasia and severe thrombocytopenia, who were refractory to platelet transfusions as a result of alloimmunization. Mean platelet life span (MPLS), recovery, plasma 111In level and splenic and hepatic uptake kinetics were studied on two occasions, one using HLA-matched platelets and the other unmatched platelets. In each case, recovery of labelled platelets at 1 h post-injection and MPLS improved with HLA matching, although this improvement was highly variable. Only two of the five subjects would have derived any significant benefit from HLA-matched as compared with unmatched platelet transfusions. It was concluded that the need exists for additional cross-matching procedures, possibly related to platelet specific antigens, in patients who remain refractory to platelet transfusion.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001788:Blood Grouping and Crossmatching; D001792:Blood Platelets / Q000378:metabolism*; D001855:Bone Marrow Diseases / Q000097:blood*; D002470:Cell Survival; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007204:Indium; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013154:Spleen / Q000378:metabolism; D013921:Thrombocytopenia / Q000097:blood* / Q000000981:diagnostic imaging; D014334:Tropolone / Q000031:analogs & derivatives
D011868:Radioisotopes; D007204:Indium; D014334:Tropolone