Effect of dietary seaweed preparations on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats.
Nineteen preparations from 8 species of edible seaweeds, sodium alginate and cellulose powder were incorporated into a basic diet in proportions ranging from 0.05% to 2.0%, and used as experimental diets. Experimental rats were fed these diets and controls were fed the basic diet for 12 weeks. All rats also received the carcinogen, 1,2-dimethylhydrazine, during above period. After 20 weeks, all rats were autopsied and the incidence of intestinal tumors induced were examined. There was a significant decrease in incidence in rats fed 6 preparations from Eisenia bicyclis, Laminaria angustata, L. angustata var. longissima and Porphyra tenera (P less than 0.05).
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens; D002351:Carrageenan / Q000494:pharmacology; D004032:Diet; D004127:Dimethylhydrazines; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D007795:Laminaria; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012624:Seaweed / Q000032:analysis; D013464:Sulfuric Acids / Q000032:analysis
D002273:Carcinogens; D004127:Dimethylhydrazines; D013464:Sulfuric Acids; D002351:Carrageenan; D019813:1,2-Dimethylhydrazine