Pig epidermis: a cell kinetic study.
The basal cell density (BCD), labelling index (LI), duration of DNA synthesis (TS) and cell cycle time (TC) have been calculated for the epidermis of pigs in the age range 4-27 months. The BCD declined progressively from 143.4 +/- 6.5 cells/mm at 4 months to 128.8 +/- 8.3 cells/mm at 15 months, whereafter the values showed little change. There was a small decrease in LI with increasing age, from 7.9 +/- 1.5% at 4 months to 5.9 +/- 1.0% at 27 months. However, the change to housing animals outdoors as compared with indoors had a greater effect on the LI (approximately 10%). Severe weathering in the skin of animals housed outdoors resulted in a very high LI (approximately 20%). Neither TS or TC varied significantly with age. TS was within the range 8.8-9.2 hr and TC 127-161 hr. In animals housed outdoors TC was reduced relative to animals housed indoors. The BCD and TS were not affected by housing conditions. The kinetic parameters investigated in the pig were similar to those reported for man.
D000375:Aging; D000818:Animals; D002250:Carbon Radioisotopes; D002453:Cell Cycle; D004261:DNA Replication; D007700:Kinetics; D008940:Mitotic Index; D012867:Skin / Q000166:cytology* / Q000378:metabolism; D012879:Skin Physiological Phenomena; D013552:Swine; D013936:Thymidine / Q000378:metabolism
D002250:Carbon Radioisotopes; D013936:Thymidine