[Ultrastructural characteristics of macrophage transformation in foam cells in in vitro experiments].
Ultrastructural features of lipid vacuole formation in foam cells were studied in a mouse macrophage culture on the use of aggregated low density lipids (a-LDL) and fibroblast-modified LDL (fm-LDL). Modification of LDL properties is a factor which induces rapid transformation of macrophages to foam cells. Catabolism of a-LDL and fm-LDL and lipid vacuole formation is carried out in two ways: with and without involvement of lysosomes. In the former case membraneless lipid vacuoles are formed, in the latter one, lipid vacuoles surrounded by a membrane.
D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D005487:Foam Cells / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008168:Lung / Q000648:ultrastructure; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000648:ultrastructure*; D051379:Mice; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
D008077:Lipoproteins, LDL
Ul'trastrukturnye osobennosti transformatsii makrofagov v penistye kletki v opytakh in vitro.