[3,6-disubstituted 1-lupinylquinoxalin-2(1H)-ones of pharmacological interest. Effect on acquisition and modification of a conditioned avoidance response in rats].
Fifteen N-lupinyl derivatives of 3-methyl-, 3-phenyl- and 3-benzylquinoxalin-2(1H)-one, variously substituted on position 6 (R = CH3O, CH3, Cl, CF3), were prepared. Of these, all 1-lupinyl-3-methylquinoxalin-2-ones exhibit a high degree of deconditioning activity in the tests of acquisition and modification of a conditioned avoidance response (C.A.R.) in rats. In both tests, compounds (II) and (IV), with R = CH3O and Cl respectively, proved more active than chloropromazine.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine / Q000494:pharmacology; D007928:Lethal Dose 50; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
D011810:Quinoxalines; D002746:Chlorpromazine
1-Lupinilchinossalin-2(1H)-oni 3,6-disostituiti d'interesse farmacologico. Effetto sull'acquisizione e sulla modificazione di una risposta condizionata di "avoidance" nel ratto.