[Carcinogenic effect of N-nitrosodimethylamine after application to rat skin].
A pronounced carcinogenic action was detected after ten-fold application of nitrosodimethylamine in 3 doses (calculated doses equal 10.0; 5.0; 1.0 mg per rat). The tumour incidence in groups is equal to 93.3%, 20.0%, 6.6% and 3.3% (in control). No morphological changes were found in the place of application. Induced tumours localized in the liver, lungs and kidneys.
D000287:Administration, Topical; D000818:Animals; D004128:Dimethylnitrosamine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008175:Lung Neoplasms / Q000139:chemically induced*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption
D004128:Dimethylnitrosamine
Kantserogennoe deĭstvie N-nitrozodimetilamina na krys pri nakozhnoĭ applikatsii.