A study of the mutagenic effect of 3-methyl-4-nitrophenol on the somatic cells of the mouse.
3-Methyl-4-nitrophenol is a resultant metabolite inside the organism when fenitrothion (O,O-dimethyl O-(3-methyl-4-nitrophenyl) thiophosphate)-containing pesticides undergo a chemical change due to the action of liver cell enzymes. It is also used as a basic compound for synthesis in the chemical industry. Groups of CFLP strain mice were treated ip with single doses (25 mg/kg) of this chemical in aqueous or alcoholic solution. Another group was treated ip with the same dose on ten weekly occasions. Chromosomes were prepared from the bone marrow cells 24 and 48 hr after the treatment. The results do not exclude the possibility of a mutagenic effect.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D055598:Chemical Phenomena; D002621:Chemistry; D002869:Chromosome Aberrations / Q000187:drug effects*; D003408:Cresols / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens; D013997:Time Factors
D003408:Cresols; D009153:Mutagens; C008636:4-nitro-3-cresol