Haemodynamic effects of fenoterol for labour inhibition during spinal or epidural anaesthesia.
Haemodynamic investigations, partly using invasive monitoring, concerning interactions between the beta-mimetic effect of fenoterol and the alpha-sympathetic blockade of spinal or epidural anaesthesia were made in a total of 49 patients during pregnancy, during caesarean section and in non-pregnant women. Haemodynamic effects of fenoterol during regional anaesthesia were compared with those during general anaesthesia (n = 17). Epidural or spinal anaesthesia enhance vascular beta-mimetic reactions at the start of tocolysis, leading to a profound but short-lasting decrease in blood pressure. This initial hypotension is more pronounced after regional than after general anaesthesia.
D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology* / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008991:Monitoring, Physiologic; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D014655:Vascular Resistance / Q000187:drug effects
D004983:Ethanolamines; D005280:Fenoterol