Simultaneous determination of lidocaine, mexiletine, disopyramide, and quinidine in plasma by high performance liquid chromatography.
A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were less than 4%.
D000889:Anti-Arrhythmia Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004206:Disopyramide / Q000097:blood; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives / Q000097:blood; D008801:Mexiletine / Q000097:blood; D011802:Quinidine / Q000097:blood
D000889:Anti-Arrhythmia Agents; D008801:Mexiletine; D008012:Lidocaine; C001173:monoethylglycinexylidide; D004206:Disopyramide; D011802:Quinidine