Influence of gluten-free diet on the gastric condition in dermatitis herpetiformis.
Achlorhydric atrophic gastritis occurs in approximately 25% of patients with dermatitis herpetiformis (DH). The effect of gluten withdrawal on the gastric condition was studied in 35 patients, with a control group of 20 patients continuing their habitual diet. Gastrointestinal examinations were performed initially and repeated after about 1 3/4 years. Adherence to the diet was confirmed by dietary interviews, improvement of malabsorption test results and intestinal villous structure, and decreased dapsone requirement. Neither the non-restricted diet nor the gluten-free diet had any effect on gastric morphology, the ability to secrete gastric acid, serum gastrin levels, or the frequency or titres of circulating parietal cell antibodies. The findings indicate that gluten is not responsible for the perpetuation of the gastric affection in DH, in contrast to the enteropathy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis; D003622:Dapsone / Q000008:administration & dosage; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000209:etiology*; D005757:Gastritis, Atrophic / Q000209:etiology*; D005983:Glutens; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000276:immunology; D013270:Stomach / Q000473:pathology
D000906:Antibodies; D005755:Gastrins; D005983:Glutens; D003622:Dapsone