Potentiation of acetazolamide induced ectrodactyly in Wistar rats by vasoactive agents and physical clamping of the uterus.
The vasoactive agents serotonin, ergotamine, and nicotine potentiate acetazolamide induced forelimb ectrodactyly (missing digits) in Wistar rats. These vasoactive agents administered alone do not produce forelimb ectrodactyly and are not known to be inhibitors of carbonic anhydrase. Additionally, physical clamping of the uterine horns in addition to oral acetazolamide administration increases the frequency of forelimb ectrodactyly, suggesting that decreased uterine blood flow can potentiate acetazolamide teratogenesis. Since the vasoactive agents used in this study are reported to possess uterine vasoconstrictive activity, a decrease in uterine blood flow is a plausible mechanism for the potentiative ability of these agents.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000086:Acetazolamide / Q000633:toxicity*; D000818:Animals; D003250:Constriction; D004357:Drug Synergism; D004878:Ergotamine / Q000494:pharmacology*; D005260:Female; D009538:Nicotine / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D012701:Serotonin / Q000494:pharmacology*; D014034:Toes / Q000002:abnormalities*; D014599:Uterus / Q000098:blood supply*; D014666:Vasomotor System / Q000187:drug effects
D012701:Serotonin; D009538:Nicotine; D000086:Acetazolamide; D004878:Ergotamine