Development of reflexes in neonatal mice prenatally exposed to methylmercury and selenite.
The development of reflexes in neonates exposed prenatally to methylmercury and selenite was investigated. Pregnant mice were assigned to one of 4 treatments; methylmercury (MeHg), selenite(Se), combination of 2 compounds (MeHg X Se) and saline control (NaCl). Mice were injected subcutaneously (s.c.) on day 9 of gestation. The dose of each compound was 30 mumol/kg. Mercury (Hg) concentrations in the neonatal brain and liver of the MeHg X Se group were slightly lower than in the MeHg group. The results of behavioral examination revealed that the MeHg X Se group showed significantly improved development compared with the MeHg group. These facts suggest the possibility that selenium compounds have protective effects against methylmercury neurotoxicity in fetuses and neonates.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001921:Brain / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008628:Mercury / Q000378:metabolism; D008767:Methylmercury Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012018:Reflex / Q000187:drug effects*; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*; D014018:Tissue Distribution
D008767:Methylmercury Compounds; D020887:Selenious Acid; D008628:Mercury; D012643:Selenium