Experimental studies on carcinogenesis in the nasal mucosa.
Of 24 Syrian golden hamsters exposed to wood dust in a concentration in the air of 30 mg/m3 for 6 h per day, 5 days a week, for a period of 40 weeks, one animal got dysplasia and one a malignant tumour in the nasal mucosa. In a group of 24 animals given 3 mg of diethylnitrosamine subcutaneously once a week for 12 weeks, a high frequency of benign and malignant tumours (mainly adenocarcinoma) of the nasal mucosa was found, but a group of similar size exposed to both wood dust and diethylnitrosamine did not show a higher frequency of nasal tumours than those given this latter substance alone.
D000230:Adenocarcinoma / Q000209:etiology*; D000818:Animals; D003043:Cocarcinogenesis; D006224:Cricetinae; D004052:Diethylnitrosamine / Q000633:toxicity*; D004391:Dust / Q000009:adverse effects*; D008647:Mesocricetus; D009297:Nasal Mucosa; D009602:Nitrosamines / Q000633:toxicity*; D009669:Nose Neoplasms / Q000209:etiology*; D011230:Precancerous Conditions / Q000209:etiology; D014934:Wood
D004391:Dust; D009602:Nitrosamines; D004052:Diethylnitrosamine