Respiration and lung function in the mouse, Mus musculus (with a note on mass exponents and respiratory variables).
Ventilatory ability, the diffusing capacity of the lung and oxygen uptake have been investigated in mice of different sizes. Breathing frequency decreased with body weight although minute ventilation (V) increased (V alpha W 1.725). Weight-specific diffusing capacity for carbon monoxide showed little variation with size. Oxygen consumption (VO2) rose with weight according to VO2 alpha W0.41. In older, larger mice this resulted in increased ventilatory requirements (V/VO2).
D000818:Animals; D001835:Body Weight; D008168:Lung / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010101:Oxygen Consumption; D011653:Pulmonary Diffusing Capacity; D012119:Respiration; D013990:Tidal Volume; D013997:Time Factors