Platelet life span in uraemia.
Platelet life span estimated by the regeneration time of platelet cyclo-oxygenase activity after acetyl salicylic acid (ASA) intake, as measured by the malonyldialdehyde (MDA) production rate was 10.3 +/- 1.0 days for healthy volunteers (n = 7), 6.7 +/- 1.0 days for haemodialysis patients (n = 13), 8.0 +/- 1.5 days for continuous ambulatory peritoneal dialysis (CAPD) patients (n = 6) and 5.0 and 4.9 days for non-dialysed uraemic patients (n = 2). In uraemic patients, the platelet cyclo-oxygenase activity was significantly impaired and it correlated with the decline in platelet life span. The restoration of the platelet life span and cyclooxygenase activity was achieved better by CAPD.
D001792:Blood Platelets / Q000378:metabolism*; D002470:Cell Survival; D006801:Humans; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D013997:Time Factors; D014511:Uremia / Q000097:blood* / Q000628:therapy