Familial differences in lithium responsive versus lithium nonresponsive psychoses.
Psychiatric life histories of 218 first degree family members of 16 lithium responsive and 33 lithium non-responsive psychotic (mood incongruent) probands were contrasted. While the morbid risk of schizophrenic spectrum disorder was 9.8% in the 142 relatives of lithium nonresponsive probands, no cases of schizophrenic spectrum disorder were found among the 76 first degree relatives of lithium responsive psychotics (p less than 0.03). Lithium responsive psychotic illnesses appear to be familially, and perhaps genetically distinct from the bulk of the schizophrenias.
D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics
D008094:Lithium