Progressive passive Heymann nephritis: induction of autologous antibodies to rat brush border by multiple injections of heterologous antiserum.
Multiple i.v. injection of a heterologous anti-rat kidney fraction 3 antiserum and guinea pig anti-rabbit F3 into rats produced a progressive immune complex glomerulonephritis. The kidney disease was characterized by diffuse beaded deposition of rat gammaglobulin along the glomerular capillaries and proteinuria. Gammaglobulin eluted from the kidneys reacted with the brush border region of normal rat kidney frozen sections. Control animals did not develop the progressive disease. It appears that multiple i.v. injections of the heterologous antisera are capable of inducing an autoimmune kidney disease which is similar to Heymann nephritis.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000096:biosynthesis*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008871:Microvilli / Q000276:immunology*; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007106:Immune Sera; D007074:Immunoglobulin G