Macrophage activation by MDP bound to neoglycoproteins: metastasis eradication in mice.
Neoglycoproteins, which bind to membrane lectins of macrophages and are selectively endocytosed, were substituted with N-acetyl-muramyldipeptide (MDP). Such MDP-conjugates are shown to be able to induce macrophage tumoricity both in vitro and in vivo in a way much more efficient than free MDP does. These MDP-neoglycoprotein conjugates are shown to protect mice against metastatic growth.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D002277:Carcinoma / Q000517:prevention & control; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007939:Leukemia L1210 / Q000517:prevention & control; D008175:Lung Neoplasms / Q000517:prevention & control; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008545:Melanoma / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009362:Neoplasm Metastasis; D011650:Pulmonary Alveoli / Q000187:drug effects; D013864:Thioglycolates / Q000494:pharmacology
D006023:Glycoproteins; D013864:Thioglycolates; D000119:Acetylmuramyl-Alanyl-Isoglutamine