[Dynamics of experimental myocardial infarct complicated by cardiogenic shock during treatment with neuroleptanalgesia].
The protective action of the 2nd type neuroleptanalgesia (NLA) preparations on the damaged myocardium in experimental infarction complicated by cardiogenic shock is documented and analysed. The use of NLA within the first 5 days of the infarction complicated by cardiogenic shock decreased the intensity of the myocardial damage in the zone around the infarction and prevented necrotic changes in teh "extra-infarction" myocardium. Consequently, cardiosclerosis developing after the infarction had a smaller size and at a lesser degree decreased the contractile capacity of the heart muscle and its energy supply. The protective influence of NLA on the myocardium in cardiogenic shock is brought about through the action of the preparations on the various pathogenetic components of shock upon which the size of the myocardial damage depends.
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D008854:Microscopy, Electron; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000648:ultrastructure; D009458:Neuroleptanalgesia / Q000379:methods; D012770:Shock, Cardiogenic / Q000473:pathology* / Q000628:therapy; D013997:Time Factors
Dinamika éksperimental'nogo infarkta miokarda, oslozhnennogo kardiogennym shokom, pri lechenii neĭroleptanal'gezieĭ.