Haematological findings in the rat following administration of nephrotoxic doses of mercuric chloride.
Single oral administration of a toxic dose of mercuric chloride (2.0 mg/kg) resulted in moderate reticulocytopenia and stress reaction in the white blood picture. A slight decrease in marrow cellularity followed the administration of 0.5 or 2.0 mg/kg. Repeated administration led to an elevated reticulocyte count and leukocytic stress reaction. An increase in marrow E: M ratio, proportion of erythroid nucleated cells in both femoral marrow and spleen was also found. The elevation of doses and prolongation of the time of treatment did not lead to a deterioration of marrow morphology; a diminution of the haemotoxicity for the rat marrow was revealed in the present experiments too.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count; D004906:Erythrocyte Count; D005269:Femur; D006400:Hematocrit; D006402:Hematologic Diseases / Q000139:chemically induced*; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008627:Mercuric Chloride / Q000506:poisoning* / Q000633:toxicity; D008630:Mercury Poisoning / Q000209:etiology; D009399:Nephrons / Q000187:drug effects*; D009504:Neutrophils / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000473:pathology
D006454:Hemoglobins; D008627:Mercuric Chloride