[Testing the loss of efficacy (tachyphylaxis) during external steroid application].
The steroids fluprednylidene-21-acetate (FA) and betamethasone-17-valerate (BV) were tested in comparison to their inactive bases for loss of activity (tachyphylaxis) after 2 weeks of application. In the croton oil test, both steroids produced equal inhibition of the pustular inflammatory reaction. The vasoconstriction test after 14 days of use revealed a clear decrease in the blanching reaction - which was, however, not statistically significant in the case of BV.
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001623:Betamethasone / Q000031:analogs & derivatives*; D001624:Betamethasone Valerate / Q000008:administration & dosage / Q000494:pharmacology*; D003436:Croton Oil / Q000009:adverse effects; D003872:Dermatitis / Q000139:chemically induced / Q000188:drug therapy; D004890:Erythema / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009824:Ointments; D011246:Pregnadienetriols / Q000008:administration & dosage / Q000494:pharmacology*; D013618:Tachyphylaxis; D014661:Vasoconstriction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D009824:Ointments; D011246:Pregnadienetriols; D003436:Croton Oil; D001623:Betamethasone; D001624:Betamethasone Valerate; C100064:fluprednidene acetate
Testungen auf Wirkverlust (Tachyphylaxie) bei der externen Steroidanwendung.