Taurine and hypotaurine inhibit light-induced lipid peroxidation and protect rod outer segment structure.
Exposure of isolated frog rod outer segments to light (5000 lux) induces membrane disorganization and swelling. An increase of about 50% on lipid peroxidation, measured by the extent of malonaldehyde formation, accompanied the light-induced damage. Taurine and hypotaurine (25 mM) prevented the increase in lipid peroxidation, and provided an entire protection of rod outer segment structure.
D000818:Animals; D000975:Antioxidants; D001001:Anura; D005609:Free Radicals; D066298:In Vitro Techniques; D008027:Light; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008563:Membrane Lipids / Q000528:radiation effects; D010786:Photoreceptor Cells / Q000187:drug effects*; D012374:Rod Cell Outer Segment / Q000187:drug effects* / Q000528:radiation effects; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D008563:Membrane Lipids; D013654:Taurine; C003949:hypotaurine