Evaluation of a topical treatment, alone and in combination with a detergent, for generalized demodicosis.
Thirty dogs (20 treated, 10 controls) with naturally-acquired generalized demodicosis were utilized to evaluate the bio-activity and safety of a liquid concentrate formulation of amitraz, with or without the addition of a nonionic detergent. The detergent was added to the treatment mixture to enhance wetting and thereby reduce the number of treatments required to return diseased animals to a normal state. Three--six miticide treatments were topically applied to dogs at 14-day intervals, at a concentration of 250 parts per million active drug. The liquid concentrate with or without detergent, was equally effective and safe as a dermatotherapy for demodicosis; addition of the nonionic detergent grossly improved the wetting characteristics of the treatment mixture; however, it did not alter the biological activity or the safety of the therapy.
D000287:Administration, Topical; D000818:Animals; D003902:Detergents; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004341:Drug Evaluation; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D013501:Surface-Active Agents; D014052:Toluidines / Q000008:administration & dosage* / Q000627:therapeutic use; D014906:Wetting Agents
D003902:Detergents; D007306:Insecticides; D013501:Surface-Active Agents; D014052:Toluidines; D014906:Wetting Agents; C014983:amitraz