Cefoxitin concentration in wound fluid.
The concentration of cefoxitin was determined in fluid obtained from human surgical wounds during the first postoperative day. Intravenous administration of cefoxitin sodium at a dosage of 1 or 2 g every six hours rapidly produced wound-fluid concentrations greater than the minimal inhibitory concentration for most susceptible organisms. After three hours, wound-fluid concentrations surpassed the serum concentrations of cefoxitin. The higher dosage resulted in higher wound-fluid levels.
D002440:Cefoxitin / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use; D005122:Exudates and Transudates / Q000032:analysis*; D006801:Humans; D011292:Premedication; D013530:Surgical Wound Infection / Q000503:physiopathology* / Q000517:prevention & control
D002440:Cefoxitin