Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel.
A worker with occupational exposure to nickel developed asthma a few months after starting work. Skin prick tests to nickel sulphate were negative. Inhalation challenge with nickel sulphate, at a concentration of 10 mg/ml for 30 min induced a late asthmatic reaction, starting 3 hr after the end of exposure leading to severe nocturnal attack. Tests for antibodies with nickel reactivity were negative.
D000328:Adult; D001249:Asthma / Q000209:etiology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D009532:Nickel / Q000009:adverse effects* / Q000276:immunology; D009784:Occupational Diseases / Q000209:etiology*; D013997:Time Factors
D007073:Immunoglobulin E; C029938:nickel sulfate; D009532:Nickel