Effect of oxytocin infusion during labor: indocyanin green elimination and serum bilirubin levels.
The elimination of indocyanin green (IGG) in selected mature newborn babies (n = 50) was investigated on the first postnatal day. The IGG dose was 2 mg/kg body weight. The half time (t1/2), the elimination constant (K2), the dye distribution volume (ml/kg), as well as the level of serum indirect bilirubin on the third postnatal day were measured and calculated. Healthy, mature newborns from spontaneous labor served as controls (n = 14): the two study groups consisted of either growth-retarded (n = 8) or acidotic (n = 8) neonates. According to the management of deliveries, they were spontaneous, assisted by oxytocin drop infusion (n = 10) or under lumbal peridural anaesthesia + oxytocin drop infusion (n = 8). In the acidotic neonates the elimination constant was significantly lower and the half time significantly longer. In the growth retarded newborn babies the difference was not significant. The increase of the level of indirect bilirubin in serum appearing in the acidotic group on the third postnatal day was significantly greater.
D000138:Acidosis / Q000097:blood / Q000378:metabolism; D001663:Bilirubin / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000378:metabolism*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000378:metabolism; D007751:Labor, Induced; D010121:Oxytocin / Q000627:therapeutic use*; D011247:Pregnancy
D010121:Oxytocin; D007208:Indocyanine Green; D001663:Bilirubin