Central nervous system-directed neuronotrophic activity present in red blood cells.
A new neuronotrophic factor has been identified in extracts of vertebrate red blood cells. The factor supports the survival in culture of neurons from vertebrate central nervous systems, and does not support the survival of several peripheral ganglionic neurons. The active molecule appears to be a slightly acidic protein of 30,000-100,000 daltons.
D000818:Animals; D001681:Biological Assay; D001921:Brain; D002478:Cells, Cultured; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D005726:Ganglia, Parasympathetic; D005727:Ganglia, Spinal; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins