Effects of Litoralon (gamma-L-glutamyl-taurine) and its analogues on fear-motivated behaviour of rats.
The effects of a single post-trial intraperitoneal administration of the dipeptide Litoralon (gamma-L-glutamyl-taurine) and some of its analogues were tested on the passive avoidance latency of male and female Wistar rats. The avoidance latency was significantly decreased by Litoralon and gamma-aminobutyryl-ethanolamine phosphate but lengthened by DL-beta-aminoisobutyryl-ethanolamine phosphate. No differences were observed between the responses of immature male and female rats following Litoralon treatment. The observed inter-group differences in passive avoidance behaviour following dipeptide administration were also demonstrable in tests of the open-field activity of the animals examined immediately after the 24-hour retention test. The results are discussed on the basis of a central Litoralon effect on emotional arousal and the anti-conflict potencies of the dipeptide.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D005260:Female; D005973:Glutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D005973:Glutamine; D013654:Taurine; C020903:glutaurine