Acute interstitial nephritis with bone marrow granulomas and uveitis.
A case of interstitial nephritis with bone marrow granulomas and uveitis was presented. A 53-year-old woman was found to be uremic in the course of rheumatoid arthritis. The renal biopsy revealed acute interstitial nephritis with eosinophilic infiltration. She also had bone marrow granulomas and uveitis. These findings were compatible with those of the syndrome described by Dobrin et al. The etiology and the pathogenesis of this syndrome remain unknown. However, the elevation of the erythrocyte sedimentation rate, raised levels of serum immunoglobulins, presence of circulating immune complexes and decreased T-cell population observed in this patient suggest the involvement of immunological disorders.
D000208:Acute Disease; D001855:Bone Marrow Diseases / Q000150:complications*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000150:complications*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications* / Q000473:pathology; D013577:Syndrome; D014605:Uveitis / Q000150:complications*