[Blood protein-inactivating atropine].
A xenobiotics-inactivating hemoprotein related to the class of pharmacologically active compounds (cholinolytics) was detected in rat blood. Ammonium sulphate fractionation, DEAE cellulose chromatography and gel filtration on Sephadex G-75 resulted in 750-fold purification of the protein; its Mr = 73 000-80 000. Multiple injections of the protein to experimental animals led to a 2-3-fold increase of the protein content in the blood.
D000818:Animals; D001285:Atropine / Q000037:antagonists & inhibitors* / Q000097:blood; D001798:Blood Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D004361:Drug Tolerance; D007700:Kinetics; D008297:Male; D010276:Parasympatholytics / Q000037:antagonists & inhibitors / Q000097:blood; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D010276:Parasympatholytics; D001285:Atropine
Belok krovi, inaktiviruiushchiĭ atropin.