Nuclear enlargement--an early change produced in mouse epidermis by carcinogenic chemicals applied topically in the presence of a promoter.
A series of 27 compounds, including 11 polycyclic hydrocarbons, 8 proximate carcinogens and 8 other compounds, were tested for their ability to induce epidermal nuclear enlargement in mouse skin. The materials were applied topically in methyl ethyl ketone containing 0.1% croton oil, repetitively for 3 days. Nuclear enlargement present on the fourth day was determined with the aid of a Quantiment image-analysing computer. The results obtained indicated a close correlation between the topical carcinogenicity of the test compounds and their ability to induce epidermal nuclear enlargement in the presence of croton oil.
D000287:Administration, Topical; D000818:Animals; D002074:Butanones / Q000494:pharmacology; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology; D003436:Croton Oil / Q000494:pharmacology; D004817:Epidermis / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006965:Hyperplasia; D051379:Mice; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000633:toxicity
D002074:Butanones; D002273:Carcinogens; D011083:Polycyclic Compounds; C005222:methylethyl ketone; D003436:Croton Oil