Pharmacokinetic monitoring of heparin therapy for regular hemodialysis.
Using a pharmacokinetic model for heparin prescription during hemodialysis leads to a precise monitoring of the coagulation time (CT) with 25% less heparin required. Two different populations were distinguished: The first group maintained stable sensitivity and elimination constant, permitting a stable prescription and giving stable CT values for up to 2 years. The other group exhibited wide variations of these parameters, necessitating daily dose monitoring.
D001780:Blood Coagulation Tests; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D006435:Renal Dialysis / Q000379:methods*
D006493:Heparin