Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid.
Seven analogs of arachidonic acid were tested for their coronary vasoactivity and their ability to inhibit LTC4 and LTD4 synthesis by lung tissue and to antagonize LTD4 induced coronary constriction. None of the seven arachidonic acid analogs significantly altered peptide leukotriene production by minced cat lung. Two of the analogs (i.e., 7, 13-diethanoarachidonic acid and 7, 10, 13-triethanoarachidonic acid) exerted modest but significant coronary vasodilation in isolated cat coronary arteries, and significantly antagonized the coronary vasoconstrictor response to LTD4. These analogs may be of interest in modulating leukotriene actions.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002415:Cats; D003331:Coronary Vessels / Q000187:drug effects; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D013189:SRS-A / Q000096:biosynthesis*; D014661:Vasoconstriction / Q000187:drug effects
D001095:Arachidonic Acids; D013189:SRS-A