An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats.
Using two-dimensional gel electrophoresis, an apparent genetic polymorphism was detected in the hypothalamus of a group of inbred Sprague-Dawley rats. The proteins involved in this polymorphism have a molecular weight of 57,000 daltons and isoelectric points ranging from 6.1 to 6.3. These proteins met four criteria that should be met before a positional shift on two-dimension gels can be attributed to a genetic polymorphism. This is the first report of the existence of a genetic polymorphism in the brains of a group of inbred Sprague-Dawley rats. The functional significance of this polymorphism is currently under investigation.
D000818:Animals; D004586:Electrophoresis; D007525:Isoelectric Focusing; D008970:Molecular Weight; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000302:isolation & purification; D011110:Polymorphism, Genetic; D011301:Preoptic Area / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D014697:Ventromedial Hypothalamic Nucleus / Q000032:analysis*
D009419:Nerve Tissue Proteins