Changes in serum transaminases, SDH and liver morphology after treatment with trypanocidal diamidines in mice.
The effects of 2 recently developed trypanocidal agents, Diamidinophenylindol (DAPI) and Diimidazolinophenylindol (DIPI) at doses of 10-30 micrograms/g intraperitoneally (i.p.) on serum GOT, GPT and sorbitol dehydrogenase (SDH) levels and on liver morphology have been investigated in mice. Pentamidine served as reference drug. Both agents caused dose-dependent increases in serum transaminases and SDH, and discrete morphological changes of the liver, e.g., fatty degenerations, azinoperipheral vacuolisation and alterations of the nuclei, at least at the higher dosage.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007211:Indoles / Q000633:toxicity*; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051379:Mice; D010419:Pentamidine / Q000494:pharmacology; D013401:Sugar Alcohol Dehydrogenases / Q000097:blood*; D000637:Transaminases / Q000097:blood*; D014344:Trypanocidal Agents / Q000633:toxicity*
C014364:4',6-bis(2'imidazolinyl-4',5'-H)-2-phenylindole; D007211:Indoles; D014344:Trypanocidal Agents; C007293:DAPI; D010419:Pentamidine; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase; D000637:Transaminases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase