The effect of immunoglobulin occurring on human sperm in vivo on the human sperm/hamster ova penetration assay.
We selected 91 infertile men who were tested for increased sperm-associated immunoglobulin and also tested in the human sperm/hamster ova penetration assay. There was a statistically significant association between the presence of increased sperm-associated IgG alone (p = 0.0218) and both sperm-associated IgG and A (p = 0.0187) when correlated with the failure to penetrate any hamster ova. There was a trend but no statistical significance when sperm-associated immunoglobulin A alone was present. There was a trend but no statistical relationship between the presence of sperm-associated immunoglobulin and the sperm penetration assay when the criteria for normality of the sperm penetration assay was a 15% or greater ovum penetration rate.
D000818:Animals; D001323:Autoantibodies; D006224:Cricetinae; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000276:immunology*; D008297:Male; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies