[Immunohistochemical findings in intrathoracic tumors. VI. N-acetyl-beta-glucosaminidase].
N-Acetyl-beta-Glucosaminidase (NAG) activity was investigated in 50 intrathoracic tumors with a histochemical method. Altogether, 22 of 50 (= 44%) different tumors showed enzyme activity in tumor tissue. The distribution of positive findings in bronchial carcinomas showed a marked difference between epidermoid carcinomas and adenoid carcinomas. Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between these tumor types.
D000118:Acetylglucosaminidase / Q000378:metabolism*; D002283:Carcinoma, Bronchogenic / Q000201:enzymology*; D004848:Epithelium / Q000201:enzymology; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000201:enzymology; D008171:Lung Diseases / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology*; D011658:Pulmonary Fibrosis / Q000201:enzymology; D012507:Sarcoidosis / Q000201:enzymology
D006596:Hexosaminidases; D000118:Acetylglucosaminidase
Immunhistochemische Befunde bei intrathorakalen Tumoren. VI. N-Azetyl-beta-Glukosaminidase.