The negative effect of the IUCD on the occurrence of heteroploidy--correlated abnormalities in spontaneous abortions: an update.
Two prior studies done in the seventies had shown that spontaneous abortions in current IUCD-wearers were never associated with morphologic abnormalities, previously demonstrated to correlate significantly with cytogenetically proven heteroploidy. This study, carried out in the early eighties and based on 45 IUCD-associated and 882 IUCD-unrelated non-molar spontaneous abortions, confirmed this negative effect of the IUCD with a difference. Structural abnormalities, suggestive of heteroploidy, were seen for the first time in IUCD-associated spontaneous abortions but their prevalence (9.8%) was significantly lower than that observed in the IUCD-unrelated abortions (54.1%). The clinical relevance of this finding is briefly discussed.
D000015:Abnormalities, Multiple / Q000209:etiology* / Q000235:genetics; D000022:Abortion, Spontaneous / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects*; D007621:Karyotyping; D011247:Pregnancy