Relation between steroid receptor levels and prolactin level in the decidua of early human pregnancy.
To clarify the relation between steroids and prolactin (PRL) production in human decidua, the levels of estrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) and the level of PRL in the decidua were determined simultaneously during early pregnancy. Cytosol, nuclear, and total ER levels and the cytosol PRL level were found to increase with the advance of gestation; whereas levels of PRs and ARs remained constant. Multiple regression analysis showed that the multiple correlation coefficient in the relationships of cellular ERs and cytosol PRL with gestational age was 0.722 and relatively high among the others. These results suggest an association between estrogen and decidual growth. Significant correlations between the cytosol PRL level and cellular PR or AR levels were seen during early pregnancy, suggesting that progestin and androgen may regulate PRL synthesis.
D003600:Cytosol / Q000032:analysis; D003656:Decidua / Q000032:analysis*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011388:Prolactin / Q000032:analysis*; D011944:Receptors, Androgen / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D011388:Prolactin