A human cell line sensitive to mutation by particle-borne chemicals.
A human lymphoblastoid cell line with ability to perform oxidative metabolism of various chemicals is mutated by the direct addition of an intact particulate soot. This experiment demonstrates that materials associated with combustion-generated particulates are biologically available and able to cause genetic changes in metabolically competent human cells.
D000393:Air Pollutants / Q000633:toxicity*; D001711:Biotransformation; D002460:Cell Line; D006801:Humans; D008214:Lymphocytes; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009154:Mutation; D011083:Polycyclic Compounds / Q000633:toxicity*
D000393:Air Pollutants; D009153:Mutagens; D011083:Polycyclic Compounds