Research in the Division of Toxicology. The importance of reactive intermediates of drug biotransformation in drug toxicity.
Within the Center for Bio-Pharmaceutical Sciences research on toxicology has its main object in toxification and detoxification of xenobiotics. The pharmacokinetics of sulfation, glucuronidation and other conjugation reactions is studied. Conjugation may prevent tissue damage that is caused by covalent binding of reactive intermediates. Systems for testing the toxicity of such intermediates are being developed, and a similar screening programme is pursued for elucidating the involvement of reactive intermediates in carcinogenesis.
D000047:Academies and Institutes; D000818:Animals; D001711:Biotransformation; D002273:Carcinogens; D006801:Humans; D009426:Netherlands; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012106:Research; D014116:Toxicology / Q000639:trends*
D002273:Carcinogens; D004364:Pharmaceutical Preparations