Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin.
Superfusion of the sensory stimulant drug capsaicin (3.3 microM) released [3H]acetylcholine from isolated myenteric plexus-longitudinal muscle strips of guinea-pig ileum, preincubated with [3H]choline. This effect was prevented by tetrodotoxin. There was a fast tachyphylaxis to the effect of capsaicin. It is suggested that capsaicin-sensitive nerve endings capable of activating intrinsic cholinergic neurones are situated in the myenteric plexus of the guinea-pig ileum.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D009197:Myenteric Plexus / Q000187:drug effects* / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin; D000109:Acetylcholine; D002211:Capsaicin