(-)-Gossypol: an active male antifertility agent.
The enantiomers of gossypol have been resolved by preparative HPLC of diastereomeric Schiff's base derivatives on a chiral bonded phase. Whereas (+)-gossypol has previously been reported to be inactive, (-)-gossypol is now shown to be active as a male oral antifertility agent in hamsters.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D006224:Cricetinae; D005260:Female; D005298:Fertility / Q000187:drug effects; D006072:Gossypol / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D011247:Pregnancy; D013237:Stereoisomerism
D003272:Contraceptive Agents, Male; D006072:Gossypol