Protection against venous thrombosis in an antithrombin-III deficient patient suffering from episodes of arterial thrombosis requiring major surgery. Effects of oral stanozolol in combination with subcutaneous heparin and intravenous AT-III.
In an antithrombin-III (AT-III) deficient patient suffering from recurrent episodes of venous and arterial thrombosis requiring major surgery an attempt was made to institute antithrombotic protection by long-term stanozolol treatment supplemented during periods of thrombogenic exposure with subcutaneous heparin and, when needed, infusion of AT-III as plasma or concentrate. Stanozolol raised the plasma levels of AT-III, demonstrating a sparing effect on the AT-III needed. Despite the repeated exposures to major surgery, protection against venous thrombosis was complete, but the arterial disease progressed and led to the demise of the patient.
D000284:Administration, Oral; D000328:Adult; D000671:Amputation, Surgical; D000990:Antithrombin III / Q000008:administration & dosage; D020152:Antithrombin III Deficiency; D004359:Drug Therapy, Combination; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage; D007871:Leg Ulcer / Q000209:etiology; D008297:Male; D013197:Stanozolol / Q000008:administration & dosage*; D013924:Thrombophlebitis / Q000188:drug therapy*; D013927:Thrombosis / Q000188:drug therapy* / Q000601:surgery
D013197:Stanozolol; D000990:Antithrombin III; D006493:Heparin; D007213:Indomethacin