How anthelmintics help us to understand helminths.
Study of the mode of action of the anti-parasitic 'hydrogenophore', closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. This uncoupling of mitochondria might be induced by a product(s) excreted by the liver fluke. The lipid extractable product(s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. A second unexpected finding indicates that closantel affects the motility of Schistosoma mansoni in vitro by interfering with mitochondrial ATP synthesis. The results obtained are suggestive of a role for aerobic metabolism in the generation of energy required for motility.
D000244:Adenosine Diphosphate / Q000096:biosynthesis; D000249:Adenosine Monophosphate / Q000096:biosynthesis; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D005210:Fasciola hepatica / Q000187:drug effects* / Q000502:physiology; D005211:Fascioliasis / Q000378:metabolism*; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D009068:Movement / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012457:Salicylamides / Q000494:pharmacology*; D012458:Salicylanilides / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000502:physiology; D012552:Schistosomiasis / Q000378:metabolism*
D000871:Anthelmintics; D007773:Lactates; D012457:Salicylamides; D012458:Salicylanilides; D019344:Lactic Acid; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; C023342:closantel