Serum lipoproteins in cholesterol-fed pigs after partial ileal bypass.
Partial ileal bypass (PIB) surgery was performed in hypercholesterolaemic mini-pigs and Yorkshire pigs fed a semipurified diet containing 1% (W/W) of cholesterol. PIB drastically reduced serum total cholesterol and phospholipid concentrations and the cholesterol: phospholipid ratio in spite of continuation of cholesterol feeding. The relative distribution of cholesterol between serum lipoproteins was affected by PIB; the surgical treatment caused an increase in the ratio of high-density lipoprotein (HDL) to low-density lipoprotein (LDL) cholesterol. Serum apo B and apo A levels were rapidly decreased by PIB. The operation induced a decrease in the cholesterol: apo B and cholesterol: apo A ratios. It is suggested that the pig is a suitable animal model to study PIB-induced changes in lipoprotein metabolism.
D000818:Animals; D001054:Apolipoproteins A / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D001835:Body Weight; D002432:Cecum / Q000601:surgery*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000378:metabolism*; D005260:Female; D007082:Ileum / Q000601:surgery*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D008074:Lipoproteins; D002784:Cholesterol