[Molecular pharmacological investigation of medicinal plant substances. II. Inhibition of acetylcholinesterase by monoterpene derivatives in vitro].
Monoterpene derivatives with spasmolytic activity inhibited acetylcholinesterase (ACHE, EC 3.1.1.7) in a dose dependent manner in vitro. The median inhibitory concentrations ranges between 10(-4) M and 10(-2) M. A significance of our finding may be the possible explanation of effects of monoterpene derivatives seen in distony of digestive tract.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors; D004524:Eels; D066298:In Vitro Techniques; D010946:Plants, Medicinal / Q000032:analysis*; D013729:Terpenes / Q000302:isolation & purification / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D013729:Terpenes; D000110:Acetylcholinesterase
Biochemisch-pharmakologische Untersuchung pflanzlicher Arzneistoffe. II. Hemmung der Acetylcholinesterase durch Monoterpenderivate in vitro.