[Substantiation of using magnet-directed localization of drugs for the treatment of thrombosis].
The possibility of in vitro lysis of fibrinous clots was shown experimentally (a model of blood flow in a vessel incompletely occluded by a thrombus) using the magnet-directed transport of trypsin immobilized on a magnet-susceptible carrier. During the clot lysis no fibrinolytics were recorded in the solution washing the clots, and lysis took place under the influence of trypsin on the magnetic carrier which precipitated on the surface of the clot and remained there for the necessary time (about 2 hours). The method of thrombus lysis suggested allows the dose of the injected drug to be decreased and does not require therapeutic concentration of thrombolytics in the general blood flow.
D004800:Enzymes, Immobilized / Q000008:administration & dosage*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D008280:Magnetics; D008863:Microspheres; D008955:Models, Cardiovascular; D014677:Pharmaceutical Vehicles; D013927:Thrombosis / Q000188:drug therapy*; D014357:Trypsin / Q000008:administration & dosage*
D004800:Enzymes, Immobilized; D005343:Fibrinolytic Agents; D014677:Pharmaceutical Vehicles; D014357:Trypsin
O predposylkakh ispol'zovaniia magnitonapravlennoĭ lokalizatsii lekarstvennykh preparatov dlia terapii trombozov.