Low-dose heparin in experimental peritonitis.
The aim of this investigation was to study the beneficial role of low-dose heparin in peritonitis. Peritonitis was induced in 20 dogs by the technique of Rosato and co-authors, 10 of which received low-dose heparin subcutaneously for 5 days in a dose of 100 units/kg body weight. Decreased mortality as well as decrease in the formation of intra-abdominal abscesses and adhesions were observed in the heparin-treated dogs. Some of the possible underlying mechanisms for beneficial effects of heparin in peritonitis are discussed.
D000038:Abscess / Q000517:prevention & control; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006493:Heparin / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D010532:Peritoneal Diseases / Q000517:prevention & control; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D000267:Tissue Adhesions / Q000517:prevention & control
D006493:Heparin