Effect of clonidine on stress-induced cortisol release in man during surgery.
The effect of clonidine on stress-induced cortisol secretion was studied in 10 patients undergoing general anesthesia for surgery; six other patients served as a control group and none of them was given clonidine. Central and peripheral alpha 2 stimulation by clonidine (average dose:0.45 mg over 60 minutes) was able to completely suppress cortisol release during surgery.
D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007023:Hypotension, Controlled; D008297:Male; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism*; D013514:Surgical Procedures, Operative
D003000:Clonidine; D006854:Hydrocortisone