Lupus nephritis in males and females.
The course of lupus nephritis in 51 males was compared to that of 337 females. Nephrotic syndrome occurred with equal frequency in males and females, hypertension was more frequent in males, rapidly progressive lupus nephritis was much more frequent in males. The overall 10-year survival rate from the onset of systemic lupus erythematosus was 41 per cent in males and 60 per cent in females. The 10-year 'renal survival' - from the clinical evidence of renal disease to 'renal death' - was 40 per cent in males and 57 per cent in females. Thus the prognosis of lupus nephritis in males was worse than in females. In 10 males and 65 females acetylation rate of sulfadimezine was studied. The predominance of slow acetylators was especially marked in males and in patients with more severe disease.
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000209:etiology*; D011379:Prognosis; D012737:Sex Factors