Action of ionic iron in carrageenin-induced inflammation: aggravated inflammatory response with destruction of granuloma.
The experiments described lead to the conclusion that ionic iron enhances inflammatory responses with insufficient removal of carrageenin, and with insufficient granuloma formation probably due to a high degree of fibrinolysis. This non-adapted response may be due to the excessive production of lipid peroxide caused by ionic iron.
D000818:Animals; D002351:Carrageenan / Q000378:metabolism*; D006099:Granuloma / Q000209:etiology* / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008054:Lipid Peroxides; D002351:Carrageenan; D007501:Iron