Biosynthesis of chrysomycins A and B. Origin of the chromophore.
The biosynthetic origin of the carbon atoms in the chromophores of chrysomycins A and B was investigated in feeding experiments using 13C labeled acetates and propionate. A biosynthetic scheme is proposed involving the condensation and rearrangement of a decaketide intermediate which contains either propionate (chrysomycin A) or acetate (chrysomycin B) as the chain initiator.
D000085:Acetates / Q000378:metabolism*; D000345:Affinity Labels; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D005285:Fermentation; D010442:Peptide Chain Initiation, Translational; D011422:Propionates / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism
D000085:Acetates; D000345:Affinity Labels; D000900:Anti-Bacterial Agents; D003470:Culture Media; D011422:Propionates