[Initial ultrastructural changes in the muscle fibers of the diaphragm in rats exposed to chlorophos].
Ultrastructural changes of rat diaphragm muscle fibers were studied after administration of chlorophos, i. e. organophosphorus inhibitor. Observations were made 10-180 seconds after treatment (concentrations--18 and 24 mM). The swelling of mitochondria and the increase in the length of sarcomeres were observed simultaneously. These changes were phasic. The swelling of mitochondria is probably due to the increase in energetical activity of muscle fibres.
D000818:Animals; D003964:Diaphragm; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects; D009132:Muscles / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D012518:Sarcomeres / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors; D014236:Trichlorfon / Q000633:toxicity*
D014236:Trichlorfon
Nachal'nye izmeneniia ul'trastruktury myshechnykh volokon diafragmy krysy pri vozdeĭstvii khlorofosom.