Modulation of anterior pituitary dopamine receptors by estradiol 17-beta: dose-response relationship.
Exposure of ovariectomized rats to estradiol-17-beta for 48-96 hr resulted in a dose-dependent reduction in the number but not the Kd of D-2 dopamine receptors of the anterior pituitary. No influence of estrogen was observed on dopamine or muscarinic acetylcholine receptors of caudate or hypothalamus. The dose-response relationship observed suggested that the influence of estrogen is directly on the pituitary, not secondary to the alteration of dopaminergic systems in the hypothalamus.
D000818:Animals; D002369:Castration; D002421:Caudate Nucleus / Q000032:analysis; D004958:Estradiol / Q000494:pharmacology* / Q000502:physiology; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D010903:Pituitary Gland, Anterior / Q000032:analysis*; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects*; D011976:Receptors, Muscarinic / Q000032:analysis / Q000187:drug effects
D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D004958:Estradiol