Scopolamine, morphine, and brain-stem auditory evoked potentials in awake monkeys.
The effects of scopolamine and morphine sulfate on brain-stem auditory evoked potentials (BAEPs) were studied in 10 rhesus (Macaca mulatta) monkeys. Study drugs were given intravenously to unanesthetized animals and BAEPs recorded at 3-min and 30-min intervals after administration of 0.1 mg/kg and 0.32 mg/kg of scopolamine and 15 min after administration of 3.2 mg/kg morphine at the end of the experiment. No significant change in either latency or amplitude of different components of BAEPs was observed.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D008253:Macaca mulatta; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology*
D009020:Morphine; D012601:Scopolamine