Effects of phenylbutazone and anabolic steroids on adrenal and thyroid gland function tests in healthy horses.
Adrenal and/or thyroid gland function tests were evaluated in horses at various times during short-term therapy with phenylbutazone, stanozolol, and boldenone undecylenate. There were no significant treatment or time effects on mean basal plasma cortisol concentrations in horses during treatment with the following: phenylbutazone, given twice daily (4 to 5 mg/kg, IV) for 5 days; stanozolol, given twice weekly (0.55 mg/kg, IM) for 12 days; boldenone undecylenate, given twice weekly (1.1 mg/kg, IM) for 12 days; or nothing. There was no significant effect of phenylbutazone treatment on the changes in plasma cortisol concentration during the combined dexamethasone-suppression adrenocorticotropic hormone (ACTH)-stimulation test. Plasma cortisol concentration was significantly decreased from base line at 3 hours after dexamethasone administration and was significantly increased from base line at 2 hours after ACTH in all horses (P less than 0.05). Likewise, the stimulation of basal plasma cortisol concentrations at 2 hours after administration of ACTH (P less than 0.05) was not affected by treatment with stanozolol or boldenone undecylenate. There were no significant treatment effects on mean basal plasma concentrations of thyroxine (T4) or triiodothyronine (T3) among horses during the following treatments: stanozolol, given twice weekly (0.55 mg/kg, IM) for 12 days; boldenone undecylenate, given twice weekly (1.1 mg/kg, IM) for 12 days; or nothing. There was a significant time effect on overall mean basal plasma T4 and T3 concentrations (P less than 0.05): plasma T4 was lower on day 8 than on days 1, 10, and 12; plasma T3 was higher on day 8 than on days 4 and 12.(ABSTRACT TRUNCATED AT 250 WORDS)
D000304:Adrenal Cortex Function Tests / Q000662:veterinary; D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006736:Horses / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology*; D013197:Stanozolol / Q000494:pharmacology; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology; D013960:Thyroid Function Tests / Q000662:veterinary; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D045930:Anabolic Agents; D014284:Triiodothyronine; D013739:Testosterone; D013197:Stanozolol; D010653:Phenylbutazone; D013974:Thyroxine; D006854:Hydrocortisone; C001371:boldenone undecylenate