[Comparative studies of 2 organic mercury compounds alone or in combination with ethanol following pre- or postnatal application in mice].
Studies on pre- and/or postnatal effects on mice were carried out with their identical exposure (2 mg Hg/kg body mass) to phenyl mercuric acetate or N,N'-bis-(dimethylmercury)-p-toluol-sulphonamide. Parameters of morphology, of residues, and behaviour teratology were taken into consideration. Potentiating combination effects were only observed with behaviour toxicological investigations after prenatal exposure to methylmercury. That concerned the breeding results of the P-generation and the capacity of the F1-generation to learn on the 30th and 31st day p.n. during a swimming test in a labyrinth. Synergistic effects were observed with both the mercury compounds in the swimming test on the 12th day p.n. after pre- as well as postnatal exposure.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D004357:Drug Synergism; D004622:Embryo, Mammalian / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008767:Methylmercury Compounds / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010662:Phenylmercuric Acetate / Q000633:toxicity*; D010663:Phenylmercury Compounds / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011597:Psychomotor Performance / Q000187:drug effects; D013723:Teratogens
D008767:Methylmercury Compounds; D010663:Phenylmercury Compounds; D013723:Teratogens; C027188:N,N-bis(methylmercury)-4-toluene sulfamide; D000431:Ethanol; D010662:Phenylmercuric Acetate
Vergleichende Untersuchungen mit zwei organischen Quecksilberverbindungen allein oder in Kombination mit Ethanol nach prä- oder postnataler Applikation an Müsen.