Intrinsic control of electroresponsive properties of transplanted mammalian brain neurons.
The present study presents the first analysis of neurons in mammalian brain transplants based on intracellular recording. The results, obtained in brain slices including both donor and host tissue, showed that neuronal precursor cells in embryonic transplants retained their ability to complete their normal differentiation of cell-type-specific electroresponsive properties. Distortions in cell aggregation and synaptic connectivity did not affect this aspect of neuronal differentiation.
D000818:Animals; D002454:Cell Differentiation; D002531:Cerebellum / Q000196:embryology*; D005071:Evoked Potentials; D006624:Hippocampus / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D009417:Nerve Tissue / Q000637:transplantation; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats