Effects of cyclopentolate eyedrops on gastric secretory function in pre-term infants.
Because of a report of necrotizing enterocolitis and death of a neonate from cyclopentolate eyedrops, we prospectively studied the effects of cyclopentolate 0.5% and 0.25% ophthalmic solutions and of a placebo on gastric volume and acid secretions in 20 pre-term infants. Placebo and cyclopentolate 0.25% eyedrops had no significant effect on the tested gastric functions. However, cyclopentolate 0.5% eyedrops significantly decreased gastric acid secretion and volume. Since this effect may predispose to the development of gastroenteritis, we recommend that cyclopentolate 0.5% be avoided in preterm infants; a weaker concentration of cyclopentolate eyedrops, however, can be used for mydriasis.
D000126:Achlorhydria / Q000139:chemically induced; D003519:Cyclopentolate / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009883:Ophthalmic Solutions; D010648:Phenylacetates / Q000494:pharmacology*; D011446:Prospective Studies
D009883:Ophthalmic Solutions; D010648:Phenylacetates; D003519:Cyclopentolate