Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels.
In this study, the infusion of physostigmine in 14 patients with affective disorder who were pretreated with methscopolamine caused significant and often profound increases in the patients' epinephrine levels, pulse rates, and blood pressure. Since physostigmine is being used experimentally in the treatment of elderly subjects who have Alzheimer's disease, these cardiovascular effects may have clinical importance.
D000328:Adult; D000544:Alzheimer Disease / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects*; D003866:Depressive Disorder / Q000097:blood / Q000503:physiopathology; D004837:Epinephrine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D019832:N-Methylscopolamine; D010276:Parasympatholytics / Q000494:pharmacology; D010830:Physostigmine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000494:pharmacology
D010276:Parasympatholytics; D012602:Scopolamine Derivatives; D010830:Physostigmine; D019832:N-Methylscopolamine; D004837:Epinephrine