Effect of parasitism with Ostertagia circumcincta on pharmacokinetics of fenbendazole in sheep.
Plasma and abomasal fluid concentrations of fenbendazole and its two major metabolites in sheep experimentally infected with Ostertagia circumcincta were compared with those in the same sheep when non-parasitised. Bio-availability of the drug was reduced in the parasitised state. There was also a reduction in the proportion of drug present in the form of metabolites in parasitised as compared with non-parasitised animals.
D000018:Abomasum / Q000378:metabolism; D000818:Animals; D001562:Benzimidazoles / Q000378:metabolism*; D001682:Biological Availability; D005273:Fenbendazole / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010029:Ostertagiasis / Q000097:blood / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D010435:Pepsinogens / Q000097:blood; D012756:Sheep / Q000469:parasitology; D012757:Sheep Diseases / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D013450:Sulfones / Q000378:metabolism; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D001562:Benzimidazoles; D010435:Pepsinogens; D013450:Sulfones; D005273:Fenbendazole; C011030:oxfendazole