Mutagenic effect of nitrilotriacetic acid on cultured human cells.
The mutagenic potential of nitrilotriacetic acid trisodium salt monohydrate (NTA) was evaluated on a human cell line (EUE) using selection for diphtheria toxin (DT) resistance. Cultures were treated with different doses of the chemical (2 X 10(-2)-2 X 10(-8) M) for 24 h, and cytotoxicity determined. NTA was effective in inducing diphtheria toxin-resistant (DTR) mutants, at all concentrations tested, except at 2 X 10(-6) M.
D000085:Acetates / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004167:Diphtheria Toxin / Q000633:toxicity; D004351:Drug Resistance; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens; D009571:Nitrilotriacetic Acid / Q000633:toxicity*
D000085:Acetates; D004167:Diphtheria Toxin; D009153:Mutagens; D009571:Nitrilotriacetic Acid