Effect of antituberculous calixarenes on phospholipase A2 susceptibility and on fusion of phospholipid bilayers.
Some homologous calixarenes or polyoxyethylene ethers that are known to suppress or enhance experimental tuberculous infection (depending on their polyoxyethylene chain lengths) were examined for their effects on phospholipid bilayers. The effect of these solutes is seen at 0.5-50p.p.m., and their effect depends upon their structure as well as that of the phospholipid substrate. The antituberculous compound HOC-12.5 (Macrocyclon) inhibits susceptibility to pig pancreatic phospholipase A2 action and to aggregation/fusion of the ternary co-dispersions of dimyristoyl phosphatidylcholine + 1-palmitoyl lysophosphatidylcholine + palmitic acid (50:11:11 molar proportions). In contrast, the protuberculous compound HOC-60 stimulates these effects. Differential scanning calorimetry suggests that these effects are probably due to modulation of the phase equilibrium in substrate bilayers by these polyethers.
D000995:Antitubercular Agents / Q000494:pharmacology*; D008051:Lipid Bilayers / Q000378:metabolism*; D009391:Nephelometry and Turbidimetry; D010740:Phospholipases / Q000494:pharmacology*; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000494:pharmacology*
D000995:Antitubercular Agents; D008051:Lipid Bilayers; D010743:Phospholipids; D011092:Polyethylene Glycols; C001664:Macrocyclon; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2