[Fate of benzo(a)pyrene in the digestive tract. 2. Appearance of metabolites].
The degradation of the B(a)P - mainly by oxidative way - began in the stomach and greatly developed in the intestine. The quinones and other hydrosoluble derivatives were the main metabolites of the B(a)P digestive tractus. The quinones predominated in stomach tissue, but the most hydrosoluble metabolites also were present in this wall. In the intestinal content, these hydrosoluble metabolites were very abundant; they seemed easily absorbable by the intestinal wall. Conversely, the quinones were excreted in faeces. A reduced metabolite was formed in intestinal and faecal contents.
D000375:Aging; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005753:Gastric Mucosa / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011809:Quinones / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D011809:Quinones; D001564:Benzo(a)pyrene
Evolution du benzo(a)pyrène dans le tube digestif. 2. Apparition des métabolites.