The effect of aspirin during aspirin "desensitisation" on compound 48/80 and histamine-induced skin responses in aspirin-sensitive asthmatics.
In a group of aspirin-sensitive asthmatics we studied skin weal and flare responses to intradermal injections of compound 48/80 and histamine during oral aspirin (ASA) provocation and after ASA "desensitisation". During provocation (bronchospasm accompanied by naso-ocular symptoms) the mean weal area after compound 48/80 increased to about 42.4% (P less than 0.05). Neither the threshold (provocative) doses of ASA nor 600 mg ASA, when given after ASA-desensitisation, significantly influenced the weal reactions to compound 48/80 (mean changes of area were -1.8% and -16.5% respectively). Aspirin did not change flare reactions to compound 48/80 and weal and flare reactions to histamine on any of the three study occasions. Initial (pre-aspirin) weal reactions to compound 48/80 after desensitisation to the threshold ASA doses were significantly reduced, but after desensitisation to 600 mg ASA were significantly increased as compared with the reactions before. These data suggest that ASA-"desensitisation" may influence the skin reactivity to non-specific mast cell degranulating stimulus in ASA-sensitive asthmatics.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects / Q000494:pharmacology*; D001249:Asthma / Q000276:immunology; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000276:immunology* / Q000628:therapy; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000276:immunology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D001241:Aspirin