Membranous glomerulonephritis associated with enterococcal endocarditis.
An autopsy case of membranous glomerulonephritis associated with enterococcal endocarditis was reported. Although enterococcal antigen was not identified in glomerular deposits, the eluate from the patient's renal tissue was shown to specifically recombine with cells of the enterococcus isolated from his own ante mortem blood. Hypocomplementemia, circulating immune complexes and antienterococcal antibodies were also observed. These findings suggest that enterococcus-related immune complexes played a role in the pathogenesis of glomerulonephritis associated with enterococcal endocarditis in this patient.
D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000276:immunology; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology; D006801:Humans; D008297:Male
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex