Intrathecal phenol and glycerin in metrizamide for treatment of intractable spasms in paraplegia. Case report.
Intractable lower extremity spasms after spinal cord injury is a significant source of morbidity. A case of refractory spasticity in paraplegia was successfully converted to flaccid paraplegia by intrathecal injection of phenol and glycerin in metrizamide. This chemical rhizolysis is simple and effective, and the presence of metrizamide allows both fluoroscopic guidance for accurate intrathecal phenol placement and good miscibility with cerebrospinal fluid. A brief comparative review of alternative therapeutic modalities is presented.
D000328:Adult; D005990:Glycerol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007866:Leg; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000627:therapeutic use*; D010264:Paraplegia / Q000188:drug therapy*; D019800:Phenol; D010636:Phenols / Q000008:administration & dosage / Q000627:therapeutic use*; D013035:Spasm / Q000188:drug therapy*
D010636:Phenols; D019800:Phenol; D005990:Glycerol; D008793:Metrizamide