Cholecystokinin intracerebroventricularly applied stimulates gastric acid secretion.
Intracerebroventricularly applied cholecystokinin-8-sulfate (CCK-8) induced a significant and dose-related increase in gastric acid output in urethane anesthetized rats. On the other hand, cholecystokinin-8-non-sulfate (CCK-8-NS), a non-active analogue of CCK-8, and pentagastrin as one of the cholecystokinin families, had no effect on gastric acid secretion. Pretreatment with atropine 5 min prior to CCK-8 as well as subdiaphragmatic vagotomy completely blocked this peptide-induced increase in gastric acid secretion. These results suggest that centrally applied CCK-8 induced a vagally mediated increase in gastric acid secretion.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects
D001285:Atropine; D012844:Sincalide