Neither dietary ethanol nor beer augments experimental colon carcinogenesis in rats.
There is an epidemiologic association between beer consumption and rectal cancer. Beer and ethanol were tested in the rat-dimethylhydrazine (DMH) experimental carcinogenesis model in order to verify this observation. Ethanol was found not to affect the number of colonic tumors induced by DMH (86 vs. 77 controls, P = 0.764). In rats fed beer and treated with DMH, there was a decrease in gastrointestinal tumor induction (P = 0.043). This instance then becomes one of many in which conclusions drawn from epidemiologic studies have been contradicted when subjected to analysis in an experimental colon carcinogenesis model.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001515:Beer / Q000633:toxicity*; D003043:Cocarcinogenesis; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004032:Diet; D004127:Dimethylhydrazines; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004127:Dimethylhydrazines; D000431:Ethanol; D019813:1,2-Dimethylhydrazine