Esophageal varices produced in dogs.
In attempts to produce esophageal varices in dogs, we designed a procedure based on the concept of hyperdynamic flow. The first stage operation involved the achievement of an arteriovenous shunt between the left renal artery and the proximal splenic vein, in concert with the distal splenic venous-left renal venous shunt. About one month after the initial operation, sixteen of the twenty-eight dogs had tolerated the manipulations. Both shunts proved to be functioning well in six of sixteen survivors, in which an ameroid constrictor was placed around the splenic vein just proximal to the confluence of the left gastric vein. Again one month later, in five of these six, esophageal varices were evidenced, both endoscopically and histologically. Arterialization of left gastric vein concomitant with the distal splenorenal shunt, gave rise to a hyperdynamic state in the upper stomach and resulting in reproducible esophageal varices.
D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D004285:Dogs; D004932:Esophageal and Gastric Varices / Q000473:pathology / Q000503:physiopathology*; D004945:Esophagoscopy; D005260:Female; D005773:Gastroscopy; D006439:Hemodynamics; D008297:Male; D012039:Regional Blood Flow; D013270:Stomach / Q000503:physiopathology