Spinal cord compression in breast cancer.
Myelography was performed on 78 patients with breast cancer who had signs or symptoms compatible with spinal cord compression. Of 42 patients (54%) with extradural defects, 21 (50%) had a complete block. All patients with positive myelograms (M+) had a positive bone scan and 41 of 42 (97%) had positive skeletal x-rays. Except for paraplegia, paraparesis, or a sensory level abnormality, signs and symptoms were usually not precise enough to accurately predict patients with cord lesions; however, back pain, paresthesias, and bladder or bowel dysfunction were significantly more common in M+ patients. Cerebrospinal fluid (CSF) protein was elevated in almost all M+ patients but also in approximately half of the M- group. Cytology and glucose analysis of CSF were not of value in predicting cord involvement. Response to treatment was better for patients with fewer sites of metastatic disease and a shorter time from diagnosis to treatment. There was no notable difference in survival between M+ and M- patients. Myelography remains the most precise tool for diagnosing spinal cord lesions. Unfortunately, the prognosis of patients with metastatic breast cancer is poor regardless of whether spinal cord compression is present.
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009192:Myelography; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011877:Radionuclide Imaging; D013117:Spinal Cord Compression / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging* / Q000628:therapy; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*
D002556:Cerebrospinal Fluid Proteins