Depression of ovarian estradiol-17 beta following single oral dose of ketoconazole.
Ketoconazole, administered as a single oral dose depressed ovarian concentration of estradiol-17 beta in rats. Estradiol-17 beta was quantitated, following dansylation, by a high-performance-liquid-chromatographic method. Control proestrous concentration was 111.2 +/- 6.9 pg/mg. With ketoconazole doses of 5 mg/kg and 20 mg/kg, the estrogen concentration was reduced to 84.0 +/- 8.4 pg/mg and 34.6 +/- 5.0 pg/mg respectively.
D000284:Administration, Oral; D000818:Animals; D004958:Estradiol / Q000032:analysis*; D005260:Female; D007654:Ketoconazole / Q000008:administration & dosage / Q000494:pharmacology*; D010053:Ovary / Q000032:analysis* / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004958:Estradiol; D007654:Ketoconazole