Ristocetin-induced platelet agglutination in four Chinese patients with Glanzmann's thrombasthenia.
We studied the degree of Ristocetin-induced platelet agglutination in 4 Chinese patients with Glanzmann's thrombasthenia. At Ristocetin concentrations of 1.2-2.0 mg/ml (final concentration) variable, abnormal responses were observed. The most notable feature in 3 of 4 patients studied was the phenomenon of dose dependent, cyclic platelet agglutination-disagglutination. However, this phenomenon could be reproduced in only one of the 2 patients who were investigated on 2 separate occasions. Variable, but often characteristic responses of thrombasthenic platelets to different concentrations of Ristocetin are a useful additional diagnostic marker for this disease.
D001791:Blood Platelet Disorders / Q000097:blood*; D005260:Female; D006723:Hong Kong; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D012310:Ristocetin / Q000494:pharmacology*
D012310:Ristocetin