[Synthesis and antiinflammatory activity of various 1,4-benzothiazine derivatives].
A new series of dihydro-4H-1,4-benzothiazine derivatives was prepared. These compounds were obtained by reductive N-alkylation reaction with sodium borohydride in acetic acid of the corresponding 4H-1,4-benzothiazine. Some of the latter compounds were synthesized by a new synthetic method employing 2-aminobenzenethiol and alkynes as starting material. Preliminary pharmacological data on the antiinflammatory activity of these compounds by using carrageenin paw edema assay are reported.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D013843:Thiazines
Sintesi ed attività antiinfiammatoria di alcuni derivati 1,4-benzotiazinici.