An extended hypothetical theory of the dose-response relations in pharmacology.
The authors present an extended version of Clark's and Ariëns's classical theory that enables the interpretation and quantitative characterization of dose-response curves which are not in accordance with classical theory. Being supported by the chemical receptor theory, the new model expands its applicability to two or multi-receptor and multi-effect systems. Mathematical interpretation of the model is given in this paper.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008433:Mathematics; D008962:Models, Theoretical; D014132:Trachea / Q000187:drug effects
D000109:Acetylcholine