Muzolimine vs. furosemide in nephrotic syndrome: further support of different carrier(s) operating for enteral absorption.
The authors have compared during 4 weeks of study the effects of furosemide (F) by oral route or i.v. and muzolimine (M)/os in 10 patients with nephrotic syndrome (NS) and normal renal function. A satisfactory diuretic response was observed with i.v. F (100 mg) and M/os (30-60 mg) with respect to the basal condition (P less than 0.001), while F/os (100 mg) was ineffective in these patients. This behaviour may be explained by the different pharmacological properties of M vs. F, by gut alterations due to the oedema of mucosa or loss of some "carrier(s)" operating for intestinal absorption of these two high ceiling diuretics.
D000328:Adult; D001835:Body Weight / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009156:Muzolimine / Q000627:therapeutic use*; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011720:Pyrazoles / Q000627:therapeutic use*; D013997:Time Factors
D004573:Electrolytes; D011720:Pyrazoles; D009156:Muzolimine; D005665:Furosemide