Three-dimensional structure of calmodulin.
The three-dimensional structure of calmodulin has been determined crystallographically at 3.0 A resolution. The molecule consists of two globular lobes connected by a long exposed alpha-helix. Each lobe binds two calcium ions through helix-loop-helix domains similar to those of other calcium-binding proteins. The long helix between the lobes may be involved in interactions of calmodulin with drugs and various proteins.
D000494:Allosteric Regulation; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000378:metabolism; D008297:Male; D008958:Models, Molecular; D011487:Protein Conformation; D051381:Rats; D013329:Structure-Activity Relationship; D014336:Troponin; D019209:Troponin C
D002147:Calmodulin; D014336:Troponin; D019209:Troponin C; D002118:Calcium