[Radiation changes in the lipid levels in liver and thymus chromatin of gamma-irradiated rats].
A study was made of the lipid content of liver and thymus chromatin of intact and gamma-irradiated (10 Gy) rats 10 and 40 min after irradiation. The composition of the chromatin-bound phospholipids was shown to differ from that of phospholipids of intact nuclei and a nuclear membrane by a much larger content of cardiolipin and sphingomyelin. A decrease in the lipid phosphorus level, increase in the amount of total cholesterol, and a 1.7-fold increase in the cholesterol/phospholipids ratio were observed after irradiation: 40 min after exposure these indices were normalized. The opposite changes were noted in the lipid content of the thymus chromatin: 10 min after irradiation no changes were detected while after 40 min more than a 1.5-fold increase in the cholesterol amount and the cholesterol/phospholipids ratio was registered. The content of cardiolipin was reliably decreased in the chromatin of both organs throughout the entire period of observation.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism / Q000528:radiation effects; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D050356:Lipid Metabolism; D008055:Lipids / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D010743:Phospholipids / Q000378:metabolism / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011836:Radiation Tolerance; D051381:Rats; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D002843:Chromatin; D008055:Lipids; D010743:Phospholipids; D002784:Cholesterol
Radiatsionnye izmeneniia kolichestva lipidov khromatina pecheni i timusa gamma-obluchennykh krys.