Comparative study on renal accumulation of aminoglycoside antibiotics.
Antibiotic activities in the subcellular fractions of rat kidney were determined after a single intraperitoneal injection of streptomycin, gentamicin and amikacin in the doses of 100 mg/kg of body weight. The concentration in the sediment fraction, which consisted mainly of lysosome and mitochondria, is a valuable index for renal accumulation and subsequent toxicity. Half-lives of the aminoglycosides in this fraction were in the order of amikacin (2.34 h), streptomycin (5.86 h), and gentamicin (9.26 h).
D000583:Amikacin / Q000378:metabolism; D000617:Aminoglycosides / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000633:toxicity; D005839:Gentamicins / Q000378:metabolism; D006207:Half-Life; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013307:Streptomycin / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin; D013307:Streptomycin