Beneficial effects of a neutral protease inhibitor in traumatic shock.
Eglin C is a polypeptide inhibitor of the neutral proteases elastase and cathepsin G. We have investigated its action in traumatic shock in rats. Eglin C (2 mg/kg) given following trauma prolonged survival time from 2.3 +/- 0.5 h to 3.6 +/- 0.4 h (p less than 0.05) in traumatized rats. Although eglin C treatment had no significant effect on the increase in plasma cathepsin D activity, eglin C administration significantly blunted plasma myocardial depressant factor (MDF) accumulation, 54 +/- 3 vs 79 +/- 8 U/ml (p less than 0.02). Our findings indicate a potential role for neutral proteases in toxic factor formation.
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002402:Cathepsin D / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D009201:Myocardial Depressant Factor / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011506:Proteins / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D015843:Serpins; D012774:Shock, Traumatic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
D009201:Myocardial Depressant Factor; D011480:Protease Inhibitors; D011506:Proteins; D015843:Serpins; C028656:eglin proteinase inhibitors; D002402:Cathepsin D