A bleeding disorder due to deficiency of alpha 2-antiplasmin.
The investigation of a 33 year old man with a lifelong bleeding tendency is described. Defective fibrinolysis was suspected in 1968, when clinical bleeding was corrected by administration of aminocaproic acid. The paper establishes the diagnosis as alpha 2-antiplasmin deficiency and describes its management with oral tranexamic acid.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000209:etiology*; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D014148:Tranexamic Acid / Q000627:therapeutic use; D000979:alpha-2-Antiplasmin / Q000172:deficiency*
D000979:alpha-2-Antiplasmin; D014148:Tranexamic Acid