A case of suspected teratogenic holoprosencephaly.
A case of holoprosencephaly is reported in which the mother was prescribed high doses of oestroprogestins during the first 5 months of the pregnancy. Investigation of the family failed to reveal any sign of physical abnormality. A normal karyotype was detected in the proband. The authors suggest that this case may shed some light on the normal and abnormal way in which embryonic fields develop.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000022:Abortion, Spontaneous / Q000517:prevention & control; D000328:Adult; D000500:Allylestrenol / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000002:abnormalities*; D004394:Dydrogesterone / Q000009:adverse effects* / Q000627:therapeutic use; D004963:Estrenes / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy
D004963:Estrenes; D004394:Dydrogesterone; D000500:Allylestrenol