Action on mitochondrial calcium metabolism of an ionophorous compound isolated from uremic plasma or normal urine.
An ionophorous compound that is one of the uremic middle molecules is able to inhibit the mitochondrial storage of calcium. Its active concentration is equivalent to that found in uremic plasma. This result can explain the diminution of phosphate calcium granules observed in mitochondria from uremic children. Moreover, this phenomenon may be involved in the calcium pool decrease observed in chronic renal insufficiency.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D014118:Toxins, Biological / Q000494:pharmacology*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D002118:Calcium