In vivo estimation of muscle protein synthesis in myotonic dystrophy.
The rate of muscle protein synthesis in patients with myotonic dystrophy has been studied, and results correlated with total muscle mass. Whole body and skeletal muscle protein synthesis were estimated by stable isotope methodology with a primed, continuous infusion of 1-[13C]leucine with measurement of incorporation of [13C]leucine into muscle protein in biopsy samples. Whole body leucine flux, protein synthesis, and protein breakdown were only slightly depressed, but muscle protein synthesis was markedly decreased, in myotonic dystrophy. This depression of muscle protein synthesis in myotonic dystrophy correlates with previous observations of impaired insulin-induced muscle uptake of amino acids and supports the suggestion that muscle wasting in this disease is the consequence of defective anabolism in muscle.
D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007930:Leucine / Q000378:metabolism; D008297:Male; D008762:Methylhistidines / Q000378:metabolism; D009124:Muscle Proteins / Q000096:biosynthesis*; D009223:Myotonic Dystrophy / Q000378:metabolism*
D008762:Methylhistidines; D009124:Muscle Proteins; D003404:Creatinine; D007930:Leucine; C028118:3-methylhistidine