Late preventive effects of several anticalmodulin drugs on galactosamine-induced liver necrosis.
Four anticalmodulin drugs: trifluoperazine (TFP), pimozide (PMZ), thioridazine (TDZ) and imipramine (IMP) (50 mg/kg, ip) were able to partially prevent Galactosamine (GAL) (600 mg/kg, ip) induced liver necrosis when given 6 h after the hepatotoxin. IMP was also effective 10 h after GAL. The possibility of calmodulin participation in late stages of GAL-induced liver injury is analyzed.
D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D005688:Galactosamine / Q000633:toxicity*; D007099:Imipramine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D013881:Thioridazine / Q000494:pharmacology; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D010868:Pimozide; D014268:Trifluoperazine; D005688:Galactosamine; D013881:Thioridazine; D007099:Imipramine