[Effect of 24-day exercise therapy on induced thrombocyte aggregation in peripheral arterial occlusive disease in Fontaine stage II].
ADP and collagen induced platelet aggregation (PA) was studied in 18 patients suffering from arterial occlusive disease (stage II Fontaine) before and after a standardized treadmill test before and after 24 days of exercise training. At the beginning of this therapy collagen induced PA after treadmill testing was increased (amplitude +11.29%, p less than 0.05, maximal slope +18.57%, p less than 0.05, integrated area +15.23%, p less than 0.05), whereas ADP induced PA showed no consistent alteration. After the 24-day treatment period increase in collagen induced PA was considerably smaller (amplitude +7.48%, n.s., maximal slope +7.35%, n.s., integrated area +11.99%, p less than 0.05), whereas ADP induced PA again showed no consistent changes. Since the treadmill exercise induced PA showed a negative linear correlation with the claudication provoking walking distance the smaller increase in PA after treatment was considered to be due to the improved metabolic situation following exercise therapy.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000628:therapy*; D003094:Collagen / Q000494:pharmacology; D048909:Diabetes Complications; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012306:Risk; D013997:Time Factors
D000244:Adenosine Diphosphate; D003094:Collagen
Einfluss einer 24tägigen Trainingsbehandlung auf die induzierte Thrombozytenaggregation bei peripherer arterieller Verschlusskrankheit im Stadium II nach Fontaine.