[Effect of cyclic nucleotides on the mitotic activity of dental anlage and alveolar bone cells in tissue culture].
A study was made of the effects of cAMP, db-cGMP and db-cAMP on the mitotic activity of the cells of the tooth anlage and alveolar bone in tissue culture of mouse embryo aged 15 days. The data indicate that db-cGMP and db-cAMP at concentrations 10(-6) M and 10(-8) M do not have any essential effect on the mitotic activity of the cells of the tooth anlage whereas cAMP inhibits the mitotic activity in these cells as compared with control. A definite relationship was established between the character of differentiation of the osseous and dental tissues in tissue culture and the concentration of cyclic nucleotides. db-cAMP, db-cGMP and cAMP raise the mitotic activity of the osteogenic cells, inhibit resorption of the alveolar bone, and stimulate formation of a new osseous tissue.
D000539:Alveolar Process / Q000187:drug effects* / Q000196:embryology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009712:Nucleotides, Cyclic / Q000494:pharmacology*; D014083:Tooth Germ / Q000187:drug effects* / Q000196:embryology
D009712:Nucleotides, Cyclic
Vliianie tsiklicheskikh nukleotidov na mitoticheskuiu aktivnost' kletok zubnykh zachatkov i al'veoliarnoĭ kosti v tkanevoĭ kul'ture.