Supraclinoid intracarotid chemotherapy using a flow-directed soft-tipped catheter.
In an attempt to avoid toxic reactions of the eye as a complication of internal carotid arterial infusion of cisplatin, carmustine, or a combination of both for the treatment of brain tumors, a new Gore-Tex/Teflon coaxial catheter system has been used for supraclinoid placement. Catheter placement was successful in 14 of 16 attempts in eight patients. Two patients experienced eye pain and conjunctivitis--a result of the chemotherapeutic agent leaking through the Gore-Tex portion of the catheter at the infusion rate of 170 ml/h. No complications were noted as long as the infusion rate was maintained at 125 ml/h or lower.
D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002343:Carotid Artery, Internal; D002404:Catheterization / Q000295:instrumentation*; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged