An example of interaction between environmental pollutants: modification of thiram toxicity to freshwater organisms by nitrites or nitrates in relation to nitrosamine synthesis.
Thiram, a dithiocarbamate fungicide, is known to evolve to dimethylnitrosamine (DMNA) when associated with nitrites. Conditions of appearance of that carcinogenic compound have been studied in short-term experiments by association of the fungicide, nitrates or nitrites, and species representative of freshwater biota. DMNA has been estimated by GLC equipped with a specific detector. Chlorella vulgaris can rapidly produce nitrites from nitrates and DMNA is obtained in presence of thiram. Daphnia magna can also synthesize DMNA but nitrites have to be added to the medium. Increased toxicity of thiram is observed. The same results are obtained on Cyprinus carpio and for a part on Brachydanio rerio. When the species are associated in a 15-day experimental food chain, and intoxicated algae feed the two other levels, no significant transfer is observed. Nevertheless, some DMNA hazard may exist for particular species exposed to thiram associated with nitrites or even nitrates if algae are present.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003445:Crustacea / Q000187:drug effects; D004347:Drug Interactions; D056890:Eukaryota / Q000187:drug effects; D005399:Fishes / Q000502:physiology*; D009566:Nitrates / Q000633:toxicity*; D009573:Nitrites / Q000633:toxicity*; D009602:Nitrosamines / Q000633:toxicity; D013859:Thiocarbamates / Q000633:toxicity*; D013893:Thiram / Q000633:toxicity*; D014873:Water Pollutants / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D009566:Nitrates; D009573:Nitrites; D009602:Nitrosamines; D013859:Thiocarbamates; D014873:Water Pollutants; D014874:Water Pollutants, Chemical; D013893:Thiram