The correlation between catecholamine and lipid peroxidation induced damage in heart cells.
Cardiocytes incubated with isoprenaline plasma showed an initial rise in the intracellular ATP levels followed by a steady fall; after two hours the ATP levels of the cells treated with the plasma were less than half that of the control cells. This fall in intracellular ATP was accompanied by morphological changes, in particular the formation of both large and small membrane blebs.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004734:Energy Metabolism / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D009206:Myocardium / Q000166:cytology*; D051381:Rats
D008054:Lipid Peroxides; D000255:Adenosine Triphosphate; D007545:Isoproterenol