[Antipoliomyelitis vaccination of young children with a new inactivated vaccine. Serological results].
An inactivated trivalent poliovirus vaccine, prepared on simian line-cells (Vero cells), has been injected in 3 doses one month apart in 36 infants, 2 to 11 months old (30 of whom were 2 to 6 months old) to determine its tolerance and antigenic efficacy. Each dose contained 40, 8 and 32 antigenic D units for the 3 types respectively. DPT vaccine was injected simultaneously in another part of the body. Before beginning the immunization program, 20 infants had significant titers of antibodies against the 3 types of poliovirus; Only 6 were triple negative. One month after the second dose of vaccine, all the infants had significant titers of antibodies against the 3 types; these titers have not been significantly enhanced one month after the third dose. Two doses of the inactivated vaccine one month apart induced a satisfactory serologic response in spite of the presence of serum maternally transmitted antibodies. There were no adverse reactions.
D000914:Antibodies, Viral / Q000032:analysis; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D011051:Poliomyelitis / Q000276:immunology / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000276:immunology; D014613:Vaccines, Attenuated
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated
Vaccination antipoliomyélitique de jeunes enfants par un nouveau vaccin inactivé. Résultats sérologiques.