Clinical and experimental neurotoxicity of 2-t-butylazo-2-hydroxy-5-methylhexane.
Seven workers developed weight loss, sensorimotor neuropathy, visual dysfunction, impaired mentation, and emotional lability shortly after the introduction of a new synthetic catalyst in a plant manufacturing reinforced bathtubs. The newly introduced catalyst, 2-t-butylazo-2-hydroxy-5-methylhexane, is shown to produce a similar syndrome in rats. Axonal degeneration of optic nerves, ascending and descending spinal tracts, and peripheral nerves appears to underlie this syndrome.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D009420:Nervous System / Q000187:drug effects* / Q000473:pathology; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology; D051381:Rats; D013116:Spinal Cord / Q000473:pathology
D001391:Azo Compounds; C044725:2-tert-butylazo-2-hydroxy-5-methylhexane