[Study of DNA synthesis in short-term cultures of mammalian cells in the evaluation of the reaction of tumor and normal tissues to irradiation and hyperthermia].
The effect of radiation of hyperthermia was estimated with a reference to the degree and duration of inhibition of DNA synthesis in the primary suspension cell cultures of Lewis lung carcinoma and bone marrow carcinoma of mice in vitro. The optimum conditions were chosen for cultivation of the primary suspension cell cultures according to the DNA synthesis. A study was made of the peculiarities of suppression and recovery of DNA synthesis in cells of Lewis lung carcinoma and bone marrow carcinoma of mice exposed to different gamma-radiation doses and hyperthermia.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism* / Q000528:radiation effects; D001854:Bone Marrow Cells; D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism* / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000378:metabolism* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006979:Hyperthermia, Induced; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D011836:Radiation Tolerance; D013997:Time Factors
D004273:DNA, Neoplasm; D004247:DNA
Issledovanie sinteza DNK v kratkosrochnykh kul'turakh kletok mlekopitaiushchikh dlia otsenki reaktsii kletok opukholeĭ i normal'nykh tkaneĭ na obluchenie i gipertermiiu.