[Comparative study of zixoryn and phenobarbital as enzyme inducers of the liver mono-oxygenase system].
It has been shown in rat experiments that administration of zixoryn brings about an increase in the liver weight and the content of cytochromes P-450 and b5, and activates the aniline-hydroxylase reaction. The induction activity pattern of zixoryn is similar to that of phenobarbital-type inducers. However, it is inferior to phenobarbital in the degree of activity and causes an atypically dramatic increment of the content of cytochrome b5. It is assumed that the mechanism of zixoryn action is linked with acceleration of the synthesis of microsomal oxidation enzymes and stabilization of cytochrome P-450 in a catalytically active state.
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D003573:Cytochrome b Group / Q000096:biosynthesis; D015786:Cytochromes b5; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010105:Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D001559:Benzhydryl Compounds; D003573:Cytochrome b Group; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C016914:flumecinol; D010634:Phenobarbital
Sravnitel'noe izuchenie ziksorina i fenobarbitala kak induktorov fermentov monooksigenaznoĭ sistemy pecheni.