Effect of histamine infusion on circulating methionine-enkephalin and catecholamine concentrations.
In 5 normal adult men, histamine was infused i.v. for 5 min at 20 micrograms/kg/h and at 80 micrograms/kg/h on two occasions one week apart. Diastolic blood pressure fell and heart rate, plasma adrenaline and noradrenaline all rose in a dose-dependent manner, but plasma methionine-enkephalin (Met-Enk) concentrations were unchanged. These results indicate that while Met-Enk may be co-stored with catecholamines (CAs) in the adrenal medulla in at least this paradigm, circulating concentrations of CAs may be altered without similar changes in plasma Met-Enk immunoreactivity.
D000313:Adrenal Medulla / Q000378:metabolism; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004744:Enkephalin, Methionine / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D011863:Radioimmunoassay
D004744:Enkephalin, Methionine; D006632:Histamine; D009638:Norepinephrine; D004837:Epinephrine