X-radiation carcinogenesis in humans.
Using a two hit theory of x-irradiation damage to DNA in ankylosing spondylitis treated patients (in a course of 10 treatments), I have found that a dose squared theory can approximately yield results which are in agreement with observation. The first hit inactivates premutational repair, while the second hit causes a mutation in an operator region which controls cell division. And average value of the immunological efficiency is used for the removal of incipient tumor cells.
D002455:Cell Division / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D013167:Spondylitis, Ankylosing / Q000532:radiotherapy