The effect of althesin, ketamine or pentothal on renal function in saline loaded rats.
Rats were prepared with chronic cannulae in the carotid artery, jugular vein and urinary bladder; they were then kept 2 days to allow recovery from surgery. A steady-state continuous saline diuresis was established, then various anaesthetic agents were injected and changes in the urine flow, sodium and potassium excretion rates, GFR, ERPF, ERBF and blood pressure were measured. Five groups of rats were studied: (1) control animals given saline in place of any anaesthetic agent, all parameters measured remained constant; (2) althesin (1.2 mg/kg), all parameters remained constant except for the blood pressure which decreased slightly for 5 min; (3) althesin (12 mg/kg); (4) ketamine (50 mg/kg); (5) pentothal (50 mg/kg). The above anaesthetics altered all of the measured parameters except urine output. Various mechanisms for these anaesthetic agents are discussed. In althesin anaesthetized rats, all the retarded renal parameters recovered within 30 min. It is concluded that for the study of renal function, if a brief anaesthesia is needed, althesin is a more suitable anaesthetic agent.
D000530:Alfaxalone Alfadolone Mixture / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000652:urine; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000652:urine; D012965:Sodium Chloride / Q000008:administration & dosage; D013874:Thiopental / Q000494:pharmacology*; D013997:Time Factors
D012965:Sodium Chloride; D007649:Ketamine; D000530:Alfaxalone Alfadolone Mixture; D012964:Sodium; D010424:Pentobarbital; D013874:Thiopental; D011188:Potassium