Catatonia associated with phenylpropanolamine overdose and fluphenazine treatment: case report.
A case is reported in which catatonia and autonomic abnormalities occurred in a patient on long-term fluphenazine decanoate following overdose with an oral anorectic agent containing phenylpropanolamine and caffeine. The catatonic symptoms showed a rapid and complete resolution following intramuscular benztropine. A possible mechanism to explain the catatonic symptoms is discussed.
D001590:Benztropine / Q000627:therapeutic use; D002110:Caffeine / Q000506:poisoning; D002389:Catatonia / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D005476:Fluphenazine / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010665:Phenylpropanolamine / Q000506:poisoning*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology
D011954:Receptors, Dopamine; D001590:Benztropine; D010665:Phenylpropanolamine; D002110:Caffeine; C011825:fluphenazine depot; D005476:Fluphenazine