Microcirculatory disorders in congenital heart diseases with insufficient or relatively excess blood supply to the greater circulation.
On the material of 25 children, who died in the first year of life of congenital heart disease, pathomorphological changes in the vessels of the microcirculatory bed of the greater omentum were studied. In 14 patients, the heart disease was characterized by reduced blood inflow to the greater circulation, in 11 children by increased inflow. A dependence of morphological changes in vessels of the microcirculatory bed on the character of disorders in central haemodynamics was documented. Adaptive and pathological changes in the microvessels are distinguished, and their clinical functional significance is assessed. The progressive development of pathological structural changes in the microcirculatory bed is considered a consequence of functional depletion not only of central (cardiac) but also of peripheral (microcirculatory system) adaptive mechanisms.
D001160:Arterioles / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D004903:Erythrocyte Aggregation / Q000209:etiology; D006330:Heart Defects, Congenital / Q000150:complications / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008833:Microcirculation; D009852:Omentum / Q000098:blood supply* / Q000473:pathology; D013923:Thromboembolism / Q000209:etiology; D014699:Venules / Q000473:pathology