C3 variants in Japanese.
By high-voltage agarose gel electrophoresis, seven phenotypes of C3 were found in Japanese. The allele frequencies for C3*S, C3*S025, C3*S02, C3*F, C3*F06, C3*F065, and C3*F08 were 0.9943, 0.0003, 0.0003, 0.0006, 0.0003, 0.0021, and 0.0021, respectively. CH50, C3/C3c protein concentrations, and C3 hemolytic activities in fresh sera with variant C3 phenotypes were within the normal ranges.
D000328:Adult; D003176:Complement C3 / Q000235:genetics*; D015932:Complement C3c; D004587:Electrophoresis, Agar Gel; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D007564:Japan; D010641:Phenotype
D003176:Complement C3; D015932:Complement C3c