Rectal induction of anaesthesia in children with methohexitone. Patient acceptability and clinical pharmacokinetics.
Rectal induction of anaesthesia with 10% methohexitone 100 mg ml-1 was used in 50 healthy children, using a standard dose of 25 mg/kg body weight. The absorption of methohexitone was rapid and reliable: the children fell asleep within 10-15 min. The plasma concentration peaked at 10-15 min and then decayed rapidly. The terminal half-life of rectal methohexitone was 1-2 h. Overall patient acceptability was good, and there were no major complications.
D000774:Anesthesia, Rectal; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D008723:Methohexital / Q000378:metabolism; D010290:Parents; D010342:Patient Acceptance of Health Care
D008723:Methohexital