[Influenza virus replication in the presence of bonafton and other inhibitors of macromolecular synthesis].
Formation of virus-specific RNAs in the presence of bonafton, actinomycin D, and cycloheximide was studied. The degree of bonafton inhibition of the synthesis of the genome and complementary RNAs in the nucleus and cytoplasm of the infected cells varied. The effect of bonafton on replication and transcription of influenza virus differs from that of actinomycin and cycloheximide. Bonafton appears to disturb the regulation of these processes, specifically inhibiting the synthesis of individual fragments of viral RNA.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D005814:Genes, Viral / Q000187:drug effects; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D046911:Macromolecular Substances; D009285:Naphthoquinones / Q000494:pharmacology*; D012367:RNA, Viral / Q000037:antagonists & inhibitors; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D046911:Macromolecular Substances; D009285:Naphthoquinones; D012367:RNA, Viral; D003609:Dactinomycin; C011180:bonafton; D003513:Cycloheximide
Repliktsiia virusa grippa v prisutstvii bonaftona i drugikh ingibitorov sinteza makromolekul.