Two cases of obsessive-compulsive disorder with depression responsive to trazodone.
Two patients with severe obsessive-compulsive disorder with superimposed depression, who had failed to respond to a wide variety of antidepressants, were treated with trazodone hydrochloride. Both seemed to obtain a rapid and impressive improvement in both their depression and obsessive-compulsive disorder while receiving trazodone. One patient subsequently had a monoamine oxidase inhibitor added to his treatment and experienced some additional improvement, but most of his improvement had occurred earlier, while he was receiving trazodone only.
D000328:Adult; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D010879:Piperazines / Q000627:therapeutic use*; D014191:Tranylcypromine / Q000627:therapeutic use; D014196:Trazodone / Q000627:therapeutic use*
D010879:Piperazines; D014191:Tranylcypromine; D014196:Trazodone