Effect of (+)-cyanidanol-3 on rat brain lipid peroxidation.
Non-enzymic lipid peroxidation was stimulated in homogenates, plasma membrane fractions and microsomes of rat brain in vitro by incubation with ascorbic acid. Malondialdehyde formation was determined by the thiobarbituric acid test. It has been established that (+)-cyanidanol-3 inhibits the ascorbic acid-stimulated lipid peroxidation in various fractions of rat brain. On the basis of these results it is suggested that (+)-cyanidanol-3 treatment protects brain suspensions against lipid peroxidation by acting as a free radical scavenger in vitro.
D000818:Animals; D001205:Ascorbic Acid / Q000037:antagonists & inhibitors; D001578:Benzopyrans / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002392:Catechin / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008861:Microsomes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001578:Benzopyrans; D008054:Lipid Peroxides; D008315:Malondialdehyde; D002392:Catechin; D001205:Ascorbic Acid