Effects of skeletal muscle regeneration on the proliferation potential of satellite cells.
Skeletal muscle satellite cells are myogenic stem cells that function to repair damaged muscle fibers. Participation of satellite cells in a regeneration response following muscle injury results in a significant reduction in their cumulative proliferation potential. The magnitude of the reduction is proportional to the number of regeneration responses in which the cells participate.
D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology; D002452:Cell Count; D002455:Cell Division; D008297:Male; D009132:Muscles / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D013234:Stem Cells / Q000502:physiology
D002045:Bupivacaine