Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat.
A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D007213:Indomethacin / Q000378:metabolism / Q000633:toxicity*; D007410:Intestinal Diseases / Q000139:chemically induced / Q000382:microbiology / Q000517:prevention & control*; D007422:Intestines / Q000382:microbiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014456:Ulcer / Q000139:chemically induced / Q000382:microbiology / Q000517:prevention & control
D004041:Dietary Fats; D007213:Indomethacin