Observations on Golgi epithelial cells and granule cells in the cerebellum of the reeler mutant mouse.
Cerebella of reeler mutant mice at two months of age were studied by the Golgi impregnation method to elucidate the detailed configurations of the Golgi epithelial cells and granule cells. On the basis of configuration of their Bergmann fibers, the Golgi epithelial cells of the reeler were relatively normal, or assumed inverted, swan neck, stellate, bipolar, small, or fan shapes, although their morphological changes were continuous rather than abrupt. Radially ascending Bergmann fibers, as well as disoriented ones, arose from the soma of these varieties of Golgi epithelial cells. In many areas, the granule cells were normally aggregated under the molecular layer and constituted the granular layer, although several granule cells were regionally arrested in migration within the molecular layer in some small areas. The axon of the granule cells ascended sinuously or obliquely, extended horizontally, looped around, or descended. In some cases, the granule cells had no T-like bifurcation of the axon, and assumed a bipolar form.
D000818:Animals; D002465:Cell Movement; D002525:Cerebellar Cortex / Q000166:cytology*; D004847:Epithelial Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008818:Mice, Neurologic Mutants; D009457:Neuroglia / Q000166:cytology; D009474:Neurons / Q000166:cytology