Naloxone prevents the analgesic action of alpha-MSH in mice.
alpha-MSH (0.1, 1, 10 micrograms) was administered intracerebroventricularly and its action on pain sensitivity was investigated by the hot-plate method in mice. alpha-MSH produced dose-dependent analgesia and this analgesic effect was prevented by naloxone (1 mg/kg, s.c.). It is possible that alpha-MSH may play a role in the mechanism of pain through endogeneous opioid systems.
D000700:Analgesics; D000818:Animals; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000037:antagonists & inhibitors*; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*
D000700:Analgesics; D009270:Naloxone; D009074:Melanocyte-Stimulating Hormones