[Changes in iodine metabolism in patients with burns treated topically with PVP-iodine].
Under exposure treatment of 33 burn patients with povidone-iodine (polyvinylpyrrolidon-iodine) preparations (Betaisodona ointment and solution) massive absorption of the iodine by the body and temporary changes in the thyroid hormones (T3 and T4 lowered, TSH raised) were found. No other clinical or laboratory-chemical side effects were observed in the patients. TRH stimulation test was carried out on 18 patients 3-6 months after ceasing povidone-iodine application. The results showed normoreaction of the hypothalamus-pituitary regulation. Povidone-iodine topical treatment of the burn patients involves them in substantial exposure to iodine, but offers no additional risk to the patients.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007455:Iodine / Q000378:metabolism*; D008875:Middle Aged; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000627:therapeutic use*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
D014284:Triiodothyronine; D011206:Povidone-Iodine; D013972:Thyrotropin; D007455:Iodine; D011205:Povidone; D013974:Thyroxine
Jodstoffwechselveränderungen bei Brandverletzten unter PVP-Jod Oberflächentherapie.