[Prostaglandin and cyclic nucleotide content of the ventricular myocardium in noradrenaline damage to the heart].
The effect of intraperitoneal noradrenaline injection (2.5 mg/kg body weight) on myocardial levels of cAMP, cHMP, PGE and PGF2 alpha of the left and right ventricles was examined in male Wistar rats. The findings were compared with morphologic changes in the myocardium and sympathetic nerves of both ventricles. Cyclic nucleotides and PGs were measured by RIA, sympathetic nerves, by a fluorescent histochemical technique; myocardial lesions were demonstrated by Lie-staining. A sharp drop was noted in cAMP and PG levels at early stages of the experiment followed by a gradual return to control values. The decrease in cAMP was less marked, and more transient, in the right ventricle. These changes were accompanied with a more pronounced damage to the left ventricle, perhaps due to differences in adrenergic innervation as well as cyclic nucleotides and PG metabolism in the examined compartments of the heart.
D000818:Animals; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000032:analysis / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000032:analysis* / Q000473:pathology; D009638:Norepinephrine / Q000633:toxicity*; D009712:Nucleotides, Cyclic / Q000032:analysis*; D011453:Prostaglandins / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D009638:Norepinephrine
Soderzhanie porstaglandinov i tsiklicheskikh nukelotidov v miokarde zheludochkov pri noradrenalinovom povrezhdenii serdtsa.