Response of human jejunal mast cells to degranulatory procedures.
The distribution of the degranulatory response of human jejunal mast cells to serum containing egg white-specific IgE and egg white (IgE-egg white) was unimodal. A similar distribution of the response to neurotensin and compound 48/80, although slightly positively skewed, was also observed. The median reduction in the number of granulated mast cells with these three degranulatory agents was remarkably parallel. There was a significant correlation between the degranulation obtained by IgE-egg white and neurotensin in the same tissue specimens. This correlation was not so apparent between the response obtained with IgE-egg white and neurotensin or neurotensin and compound 48/80. A possible history of allergic disease did not influence the results.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D002452:Cell Count; D004529:Egg White; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D007073:Immunoglobulin E / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000166:cytology*; D007583:Jejunum / Q000166:cytology*; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D008875:Middle Aged; D009496:Neurotensin / Q000494:pharmacology; D012737:Sex Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D007073:Immunoglobulin E; D009496:Neurotensin; D003189:p-Methoxy-N-methylphenethylamine