[Possible use of exclusive ghosts of autologous erythrocytes for directed transport of antibiotics].
Incorporation of rubomycin into exclusive shades of erythrocytes amounted to 7.1 per cent, that of tetracyclines to 6.9-8.9 per cent. Determination of stability of the erythrocyte containers showed that leakage of the antibiotics proceeded during the first 30 minutes of incubation at 37 degrees C when titrated with the Hanks solution. It varied with respect to different antibiotics. With the use of blood serum for titration stability of the erythrocyte containers probably increased. After incubation for 30 minutes only traces of the tetracycline derivatives were detected in the supernatant liquid while rubomycin was not detectable at all. Therefore, the study showed that the exclusive shades of autologous erythrocytes may be in principle used for transport of water-soluble antibiotics.
D000818:Animals; D003630:Daunorubicin / Q000008:administration & dosage*; D004355:Drug Stability; D004910:Erythrocyte Membrane; D051381:Rats; D012995:Solubility; D013754:Tetracyclines / Q000008:administration & dosage*
D013754:Tetracyclines; D003630:Daunorubicin
O vozmozhnosti ispol'zovaniia zamknutykh teneĭ autologichnykh eritrotsitov dlia napravlennogo transporta antibiotikov.