Ketamine: behavioral effects of subanesthetic doses.
Effects of subanesthetic doses of ketamine (0.25 and 0.5 mg/kg) on memory, cognition, psychomotor function, subjective moods, and incidence of adverse reactions were investigated in 34 healthy young volunteers. The drug caused impairment of immediate and delayed recall. Most of the impairment was due to interference with retrieval processes. Recovery was virtually complete 60 minutes after administration. The incidence of adverse reactions was high. Benzodiazepines need to be administered even when ketamine is used in subanesthetic doses.
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects*; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007649:Ketamine / Q000494:pharmacology* / Q000633:toxicity; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D001523:Mental Disorders / Q000139:chemically induced; D008606:Mental Processes / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D009325:Nausea / Q000139:chemically induced; D011597:Psychomotor Performance / Q000187:drug effects*; D014786:Vision Disorders / Q000139:chemically induced
D007649:Ketamine