The NADP binding site on rabbit muscle aldolase.
Rabbit muscle aldolase binds NADPH with a 1:1 stoichiometry and with a dissociation constant 18 microM. Three sites of the dinucleotide are involved in the binding: the adenosyl diphosphate moiety, the nicotinamide-ribose, and the nicotinamide ring. These data show the existence of a specific dinucleotide binding site in the aldolase molecule.
D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D066298:In Vitro Techniques; D009132:Muscles / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D011817:Rabbits
D009249:NADP; D005634:Fructose-Bisphosphate Aldolase