Effect of salinomycin level on nutrient digestibility and ruminal characteristics of sheep and feedlot performance of cattle.
A sheep digestion trial and two feedlot trials with cattle were conducted to study effects of an ionophore, salinomycin, on nutrient digestibility, ruminal metabolism and cattle performance. In trial 1, addition of salinomycin at 5.5, 11 or 22 ppm to 60% concentrate diets fed to ruminal-cannulated rams had no effect (P greater than .05) on apparent digestibility of dry matter (DM), organic matter (OM), neutral detergent fiber (NDF), acid detergent fiber (ADF) or starch in comparison with control diets. Apparent nitrogen (N) digestibility was increased (P less than .05) in animals fed salinomycin. Salinomycin did not affect total volatile fatty acid (VFA) concentrations in the rumen, but resulted in a linear (P less than .05) increase in molar proportion of propionate and a linear (P less than .05) decrease in molar proportions of acetate and butyrate and in acetate:propionate ratios. Shifts in VFA proportions were fully expressed within 4 d after salinomycin was added to the diet. In trial 2, salinomycin was added at 5.5, 11, 22 or 33 ppm to 85% concentrate diets fed to finishing steers. Salinomycin level had a quadratic effect (P less than .05) on daily weight gain and resulted in a quadratic (P less than .05) decrease in feed intake with a resultant average improvement of 10.3% in feed efficiency. Salinomycin (5.5, 11, 16.5 or 22 ppm) and monensin (22 ppm) were added to 90% concentrate diets in trial 3 and produced increased rates of gain without affecting feed intake.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002417:Cattle / Q000469:parasitology / Q000502:physiology*; D003044:Coccidia / Q000302:isolation & purification; D003049:Coccidiostats / Q000008:administration & dosage / Q000494:pharmacology*; D004063:Digestion / Q000187:drug effects; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000469:parasitology; D005503:Food Additives; D006863:Hydrogen-Ion Concentration; D008297:Male; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology; D012417:Rumen / Q000187:drug effects* / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D000095662:Polyether Polyketides
D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D005232:Fatty Acids, Volatile; D005503:Food Additives; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides