Macro serum CK-BB in a woman with severe primary hypothyroidism.
We report the case of a woman with severe hypothyroidism and without concomitant myocardial damage, in whom elevated CK-MB values were measured by radioimmunological and enzymatic methods before and after thyroid replacement therapy. The patient's CK-MB activity was shown to be actually due to an atypical CK band between CK-MM and CK-MB (also termed "macro CK" or "idiopathic serum CK-BB").
D000368:Aged; D001921:Brain / Q000201:enzymology; D011232:Chemical Precipitation; D003402:Creatine Kinase / Q000097:blood*; D004586:Electrophoresis / Q000379:methods; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000201:enzymology*; D007120:Immunochemistry; D007527:Isoenzymes; D009132:Muscles / Q000201:enzymology; D011863:Radioimmunoassay
D007527:Isoenzymes; D003402:Creatine Kinase