Inhibition of monoamine oxidase by metaiodobenzylguanidine, a new radiodiagnostic agent.
Metaiodobenzylguanidine, which is used in the diagnosis and treatment of pheochromocytoma, produced 50% inhibition of monoamine oxidase at a concentration of 8 X 10(-6) M in vitro. These results suggest that a careful study of the structure of a new radiodiagnostic agent should be done to anticipate and prepare for possible unwanted biological effects when administering the preparation to patients.
D019797:3-Iodobenzylguanidine; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors; D013565:Sympatholytics / Q000494:pharmacology*; D014001:Tin / Q000494:pharmacology; D017971:Tin Compounds
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008996:Monoamine Oxidase Inhibitors; D013565:Sympatholytics; D017971:Tin Compounds; C023599:stannous chloride; D019797:3-Iodobenzylguanidine; D014001:Tin