Lack of effect of entorhinal kindling on L-[3H]glutamic acid presynaptic uptake and postsynaptic binding in hippocampus.
Sodium-independent L-[3H]glutamic acid binding and sodium-dependent L-[3H]glutamic acid high affinity uptake were measured in hippocampal membranes of rats administered electroshock seizures or kindled to class 5 seizures by entorhinal cortical stimulation. There were no differences in these glutamatergic synaptic markers among electroshocked, kindled, or surgical control animals. Entorhinal kindling is not a reflection of activity-regulated facilitation of perforant path glutamatergic neurotransmission.
D000818:Animals; D002531:Cerebellum / Q000378:metabolism; D004597:Electroshock; D005971:Glutamates / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000378:metabolism; D013569:Synapses / Q000378:metabolism*; D014316:Tritium
D005971:Glutamates; D014316:Tritium