Meningo-encephalitis accompanying retinochoroiditis in a murine model of congenital toxoplasmosis.
A histopathological study of the brains of adult mice infected in utero with Toxoplasma gondii and presenting manifestations of ocular toxoplasmosis is reported. All brains contained Toxoplasma tissue cysts. A sub-acute/chronic meningo-encephalitis was the main feature of the inflammatory response in the brain. Microscopical features suggest that autoimmune processes may play a part in the disease. We suggest that our mouse model will provide a simple and inexpensive tool for the investigation of histopathological processes in the CNS resulting from congenital Toxoplasma infection.
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D002831:Choroid Plexus / Q000473:pathology; D002833:Choroiditis / Q000150:complications*; D004195:Disease Models, Animal; D008590:Meningoencephalitis / Q000150:complications* / Q000473:pathology; D051379:Mice; D013346:Subarachnoid Space / Q000473:pathology; D014124:Toxoplasmosis, Animal / Q000150:complications / Q000151:congenital* / Q000473:pathology; D014126:Toxoplasmosis, Ocular / Q000150:complications / Q000151:congenital*