[Effect of radiation on the formation of hydrocortisone metabolites in the perfused rat liver].
A study was made of the absorption of exogenous hydrocortisone and formation of its metabolites in isolated liver of intact and exposed rats in conditions of recirculating perfusion. It was shown that the absorption of the hormone by the liver of irradiated rats was greatly lowered but the content of most metabolites found in the perfused medium of irradiated liver increased as compared to the control. It is suggested that irradiation inhibits subsequent transformations of the hydrocortisone metabolism products.
D000308:Adrenocortical Hyperfunction / Q000209:etiology / Q000378:metabolism; D000818:Animals; D006854:Hydrocortisone / Q000378:metabolism* / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D010477:Perfusion; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats
D006854:Hydrocortisone
Vliianie oblucheniia na obrazovanie metabolitov gidrokortizona v perfuziruemoĭ pecheni krys.