Enhancement of phagocytosis by different anti-neoplastic drugs.
The effect of various anti-neoplastic drugs on erythrophagocytosis was studied. All of them were able to induce a significant enhancement of phagocytosis when administered at single high doses to normal mice. The effect was exerted on antibody dependent phagocytosis and was not due to local inflammatory reactions since the subcutaneous route also induced increased phagocytic activity. Since the drugs tested are commonly used in cancer chemotherapy, their enhancing effect on phagocytosis may be relevant in the regulation of host defense mechanisms.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D005122:Exudates and Transudates / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects*
D000970:Antineoplastic Agents