Effects of glycine and GABA on the ganglion cels of the retina of the skate Raja erinacea.
Application of glycine and GABA caused inhibition of light-evoked activity from different populations of 'ON' center ganglion cells in the retina of the skate (Raja erinacea). Cells affected by glycine were not affected by GABA and vice-versa. Addition of 100 microM strychnine to the glycine-containing perfusate caused a resumption in light-evoked responses of the cells. The action of GABA was antagonized by 100 microM bicuculline methochloride, but not by picrotoxin. Autoradiography revealed the presence of [3H]glycine accumulating amacrine cells.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005399:Fishes; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D010852:Picrotoxin / Q000494:pharmacology; D012160:Retina / Q000187:drug effects*; D012165:Retinal Ganglion Cells / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D001640:Bicuculline; D005998:Glycine; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid