Diuretic-induced gout in elderly women.
During a 21/2-year period, gout was diagnosed in 51 men and 9 women at the Rheumatology Unit in Bristol. The men had a mean age of 52 years and mean age of onset of gout of 46 years, whereas the women had a mean age of 82 years and a mean age of onset of 77 years. All the women were on long-term diuretic therapy compared to 33% of the men; 77% had mild impairment of renal function and 44% had tophi. The men could recall four times as many attacks of acute gout as the women. Elderly women are particularly prone to diuretic-induced tophaceous gout but less likely to present with acute gout than men.
D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000009:adverse effects*; D005260:Female; D006073:Gout / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood
D004232:Diuretics; D014527:Uric Acid; D003404:Creatinine