[Effect of furosemide, hypothiazide and urea on the physicochemical properties of blood serum proteins in rats].
It has been shown by gel chromatography and electrophoresis in polyacrylamide gel that single and chronic therapeutic doses of furosemide and hypothiazide did not alter the structure of rat blood serum proteins. Exception was a single administration of hypothiazide that provoked the formation of labile protein associations. In contrast, administration of urea to the animals resulted in the formation of large stable aggregations of serum proteins. The associations contained albumin, transferrin, immunoglobulins and group-specific proteins situated on the electrophoregram between transferrin and albumin.
D000818:Animals; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002850:Chromatography, Gel; D004232:Diuretics; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006852:Hydrochlorothiazide / Q000494:pharmacology*; D008297:Male; D051381:Rats; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology*; D014508:Urea / Q000494:pharmacology*
D001798:Blood Proteins; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D005665:Furosemide; D014508:Urea
Vliianie furosemida, gipotiazida i mocheviny na fiziko-khimicheskie svoĭstva belkov syvorotki krovi krys.