Lifetime toxicity of chloroform and bromodichloromethane when administered over a lifetime in rats.
Chloroform (CHCl3) and bromodichloromethane (CHBrCl2) are the two most common haloorganic contaminants of chlorinated drinking water. A significantly increased incidence of hepatic neoplastic nodules was found in female rats when each of these compounds was administered in drinking water to Wistar rats throughout their life span. Hepatic adenofibrosis was also produced by chronic ingestion of these two halomethanes.
D000232:Adenofibroma / Q000139:chemically induced; D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002725:Chloroform / Q000633:toxicity*; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D022882:Trihalomethanes
D006846:Hydrocarbons, Halogenated; D022882:Trihalomethanes; C025191:bromodichloromethane; D002725:Chloroform