[Effect of nonsteroidal anti-inflammatory agents on the myocardial blood supply and oxygen regimen].
Experiments on intact cats were made to study the effect of intravenous injection of voltaren (4 mg/kg) and intraventricular injection of indomethacin (4 mg/kg), ibuprophen (5 mg/kg), and butadion (22 mg/kg) on the coronary circulation and oxygen consumption by the myocardium. Indomethacin and butadion decreased the volumetric velocity of the coronary circulation and to a lesser degree oxygen consumption by the myocardium in all the experiments, whereas voltaren in 8 of 15 experiments. Ibuprophen and voltaren (in part of experiments) led to an increase in the coronary circulation and to greater oxygen utilization by the myocardium.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*
D000893:Anti-Inflammatory Agents
Vliianie nesteroidnykh protivovospalitel'nykh sredstv na krovosnabzhenie i kislorodnyĭ rezhim miokarda.