[Regions of the human genome containing homologs of the oncogenes and retrovirus genes. 3. The primary structure of the mos-related region CL-1 from the ORAgp5 locus].
The nucleotide sequence of 686 bp from the cloned human genome locus gp5 has been determined. Analysis of this sequence has revealed a statistically significant homology with both the viral and murine mos genes. The region of mos homology contains two adjacent homologous domains, whereas their counterparts in viral mos gene are separated by 471 bp. The position of mos homologous region in the close vicinity to LTR of endogenous human viral-like repeat is in accordance with the hypothesis of retroviral involvement in the process of mos gene amplification.
D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular / Q000379:methods; D005784:Gene Amplification; D005796:Genes; D005814:Genes, Viral; D006801:Humans; D008980:Moloney murine sarcoma virus / Q000235:genetics; D009857:Oncogenes; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics*
Uchastki genoma cheloveka, soderzhashchie analogi onkogenov i genov retrovirusov. 3. Pervichnaia struktura mos-rodstvennogo uchastka CL-1 iz lokusa ORAgp5.