Myosin switches in skeletal muscle development of an urodelan amphibian, Pleurodeles waltlii. Comparison with a mammalian, Mus musculus.
The isomyosins from dorsal axial muscle, which appear successively through metamorphosis of P.waltlii, are shown to be composed of identical fast-type light chains but of distinct heavy subunits. We observe that this modification goes with a change in ATPase activity as also in the case of mouse. Metamorphosis in amphibian as well as birth in mammalian are thus both accompanied by the synthesis of new myosins of higher catalytic efficiency.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000032:analysis*; D007814:Larva / Q000201:enzymology; D008675:Metamorphosis, Biological; D051379:Mice / Q000254:growth & development*; D024510:Muscle Development; D009132:Muscles / Q000201:enzymology; D009218:Myosins / Q000032:analysis*; D010999:Pleurodeles / Q000254:growth & development*; D012455:Salamandridae / Q000254:growth & development*
D007527:Isoenzymes; D009218:Myosins