Effects of aerosol corticosteroids on the voice: triamcinolone acetonide and beclomethasone dipropionate.
The present investigation compared the effects of triamcinolone acetonide (Aristocort Aerosol) and beclomethasone dipropionate (Vanceril Inhaler) on the vocal functioning of 11 chronic asthmatics. Using conventional aero-acoustic techniques, subjects' vocal fundamental frequency, maximum phonation time, and oral air volume velocity were sampled at baseline (oral corticosteroid use) and at the end of the first and second year of aerosol triamcinolone acetonide use. At the end of the second year of aerosol triamcinolone acetonide use, all subjects discontinued use of this compound and began use of aerosol beclomethasone dipropionate. Subjects' vocal performance then was sampled after 1 year of aerosol beclomethasone dipropionate use. Results of this study suggest that aerosol triamcinolone acetonide reduced the vocal dysfunction observed during the baseline period. When aerosol beclomethasone dipropionate was used, however, subjects' vocal performance was similar to that observed during the baseline period (oral steroid use).
D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010699:Phonation / Q000187:drug effects; D014222:Triamcinolone Acetonide / Q000009:adverse effects* / Q000627:therapeutic use; D014831:Voice / Q000187:drug effects*; D014833:Voice Quality / Q000187:drug effects
D000336:Aerosols; D014222:Triamcinolone Acetonide; D001507:Beclomethasone