[Central inhibition of external pancreatic secretion by D-ala-2-metenkephalinamide in rats].
Intracerebroventricular injections of D-Ala-2-Metenkephalinamide (D Alamide), a slowly metabolized Metenkephalin analogue, were made to conscious rats equipped with a chronic pancreatic fistula allowing the collection of pure pancreatic juice in its entirety. D Alamide induced a dose-related decrease in the volume of basal pancreatic secretion, as well as of bicarbonate and protein outputs. The effective doses of D Alamide were of the same order of magnitude as those necessary to induce analgesia or to decrease intestinal transit time in rats, as reported by others. The effect of D Alamide was totally blocked by naloxone, an opiate antagonist known to easily traverse the blood-brain barrier, while no blockade was found with naloxone methyl-bromide, an opiate antagonist which traverses the blood-brain barrier poorly and thus acts only peripherally. These results strongly suggest that the inhibition of pancreatic secretion induced by D Alamide is a central effect.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010111:Oxymorphone / Q000494:pharmacology; D010189:Pancreatic Juice / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D009270:Naloxone; D004744:Enkephalin, Methionine; C013801:enkephalin-Met, Ala(2)-; D010111:Oxymorphone
Inhibition centrale de la sécrétion pancréatique externe par le D-ala-2-metenképhalinamide chez le rat.