Intracranial hemorrhages due to phenylpropanolamine.
We describe 2 patients with intracranial hemorrhage after ingestion of diet pills containing phenylpropanolamine (PPA) in combination with caffeine. The first patient had bilateral simultaneous intracerebral hemorrhages, and the second had a subarachnoid hemorrhage. PPA is widely used most often without prescription and causes intracranial hemorrhage more often than has been realized. The mechanism may be induction of a transient hypertensive crisis.
D002110:Caffeine / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D010665:Phenylpropanolamine / Q000009:adverse effects*; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced
D010665:Phenylpropanolamine; D002110:Caffeine