Chelation in metal intoxication. XIV. Comparative effect of thiol and amino chelators on lead-poisoned rats with normal or damaged kidneys.
D-Penicillamine (DPA), diethyldithiocarbamate (DDC), L-cysteine, ethylenediaminetetraacetic acid (EDTA), cyclohexylenediaminetetraacetic acid (CDTA), and diethylene triamine pentaacetic acid (DTPA) were compared for their efficacy to enhance urinary excretion of Pb, to reduce Pb concentration of body organs, and to restore the enhanced urinary excretion of delta-aminolevulinic acid (delta-ALA), the inhibited activities of blood delta-ALA dehydratase, and renal enzymes in Pb-administered rats (10 mg/kg, po, 4 weeks) with normal or experimentally damaged kidneys. The acute renal damage was induced by uranyl acetate (3 mg/kg, sc, once) prior to treatment with the chelators (0.3 mmol/kg, ip, twice) and evaluated by enhanced urinary excretion of diagnostic enzymes and inhibition in their renal activities. Among thiol chelators, DPA was the most effective followed by DDC in enhancing the urinary excretion of Pb, reducing the concentration of Pb in blood, kidneys and liver, and in restoring Pb-induced biological alterations in urine, blood, and kidneys. Among amino carboxylic acids, DTPA was the most effective and EDTA and CDTA were about equally potent in countering Pb toxicity. Protection was more marked in animals with normal kidneys than in those with acutely damaged kidneys.
D000469:Alkaline Phosphatase / Q000652:urine; D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000652:urine; D002614:Chelating Agents / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000652:urine; D007854:Lead / Q000032:analysis / Q000652:urine; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009942:Organometallic Compounds; D000623:Porphobilinogen Synthase / Q000097:blood; D051381:Rats; D013054:Spectrophotometry, Atomic; D014501:Uranium / Q000633:toxicity
D002614:Chelating Agents; D009942:Organometallic Compounds; C005460:uranyl acetate; D007854:Lead; D014501:Uranium; D000622:Aminolevulinic Acid; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D000623:Porphobilinogen Synthase