Effects of alcohol exposure during different periods of development: changes in hippocampal mossy fibers.
Exposure to 10-12 g/kg/day of alcohol either during days 1-10 or 11-21 of gestation had no detectable effect on hippocampal mossy fiber development. Exposing artificially reared rat pups to 7.0-7.5 g/kg/day of alcohol during days 1-10 postpartum dramatically altered the organization of the Timm-stained mossy fiber terminal field when the animals were examined as adults, suggesting that alcohol exposure during a period equivalent to the human third trimester is more deleterious to brain development than exposure during periods equivalent to either the first or second trimesters.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D006624:Hippocampus / Q000002:abnormalities*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol