Effects of endogenous sugar acids on the ventromedial hypothalamic nucleus of the rat.
Effects of certain endogenous sugar acids such as 2-deoxytetronic acid (2-DTA) and 3-deoxypentonic acid (3-DPA) were investigated on the neuronal activity of the ventromedial hypothalamic nucleus (VMH) in the rat. Electrophoretically applied 2-DTA significantly and specifically facilitated the activity of glucoreceptor neurons in the VMH, while 3-DPA suppressed their activity. However, non-glucoreceptor neurons were not affected by these sugar acids. These results reinforces the previous suggestion that 2-DTA and 3-DPA also might act as endogenous satiety and hunger substances, respectively.
D000818:Animals; D001931:Brain Mapping; D006815:Hunger / Q000502:physiology; D006885:Hydroxybutyrates / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000502:physiology; D013329:Structure-Activity Relationship; D013400:Sugar Acids / Q000494:pharmacology* / Q000502:physiology; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects*
D006885:Hydroxybutyrates; D013400:Sugar Acids; C041038:3,4-dihydroxybutanoic acid; C041039:3-deoxypentonic acid