Effects of urinary pH on renal interactions between probenecid and cefsulodin in rabbits.
The effect of urinary pH on renal interaction of cefsulodin and probenecid was tested in rabbits. Probenecid was reabsorbed in acidic urine (fractional excretion [FE] = 8 +/- 4%) and secreted in alkaline urine (FE = 492 +/- 258%). Renal excretion of cefsulodin alone was not affected by the urinary pH (FE = ca. 100%). In acidic urine, probenecid significantly reduced tubular secretion of cefsulodin (FE = 74 +/- 8%). An inverse pattern was observed in alkaline urine (FE = 122 +/- 18%).
D000818:Animals; D002441:Cefsulodin / Q000652:urine*; D004347:Drug Interactions; D005919:Glomerular Filtration Rate; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000378:metabolism*; D011339:Probenecid / Q000652:urine*; D011817:Rabbits
D002441:Cefsulodin; D011339:Probenecid