The thyroxine screening index in congenital hypothyroidism screening.
A modification of the RIA total thyroxine assay from a dry drop of blood has been applied in 5-day-old neonates for the screening of congenital hypothyroidism. For first classification, the thyroxine screening index was used in 13 500 newborns; it proved to be simple, rapid and economically acceptable. In borderline cases, more detailed examinations were carried out, viz. estimation by RIA of thyroid stimulating hormone, thyroxine and thyroxine-binding globulin from venous blood. The incidence of permanent and transient impairment of thyroid function is shown in a special graph.
D003409:Congenital Hypothyroidism; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D007231:Infant, Newborn; D008403:Mass Screening / Q000379:methods; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood*
D013972:Thyrotropin; D013974:Thyroxine