Protracted histopathological change of the liver necrosis induced by Shwartzman reaction. An experimental animal model of liver cirrhosis?
Severe pathological fibrotic change of rabbits treated with endotoxin was produced. The liver of the rabbits that died within 14 days showed severe architectural distortion through wide fibrotic band which could be called morphologically post necrotic liver cirrhosis. On the other hand, in the liver of the rabbits that remained alive more than 14 days thin septal nodular structures were observed. This experimental model is proposed as a tool for the further study of the pathogenesis of human liver cirrhosis.
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004731:Endotoxins / Q000633:toxicity; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology*; D009336:Necrosis; D009929:Organ Size; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D013997:Time Factors
D004731:Endotoxins