Relative DNA content in lymphocytes and buccal mucosa of patients with sex chromosomal anomalies.
Cytophotometric estimation of DNA values from human buccal mucosa and lymphocyte culture nuclei shows a difference related to different X chromosomal abnormalities, namely, del X, XO, XXX and XXY. The values in the buccal mucosa in all cases except XXX were similar to the normal XX and XY. In lymphocytes nuclei, however, a steady increase in the DNA content at a significant level could be related to an increase in the number of X chromosomes. The similarity in the DNA values of normal XX and XY controls may be attributed to asynchrony in the replication patterns of X and Y chromosomes.
D002467:Cell Nucleus / Q000378:metabolism; D002610:Cheek; D004247:DNA / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009061:Mouth Mucosa / Q000378:metabolism*; D012729:Sex Chromosome Aberrations / Q000378:metabolism*
D004247:DNA