TSH-stimulated electrical excitation in thyroid cells.
This report demonstrates TSH-stimulated electrical excitation in cultured porcine thyroid cells. TSH depolarizes the thyroid cell membrane potentials and causes the appearance of action potentials, which occur in a burst. The burst is preceded by depolarization and after the burst, during which usually 2 spikes are seen, a repolarization occurs. This TSH-induced electrical excitation is associated with iodide discharge.
D000818:Animals; D004594:Electrophysiology; D007454:Iodides / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D013552:Swine; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D013972:Thyrotropin / Q000494:pharmacology*
D007454:Iodides; D013972:Thyrotropin