Effects of dietary protein restriction on the course of early renal failure.
Two groups of patients with histologically proven glomerulonephritis and chronic renal failure were studied. Group 1 comprised 28 patients with an endogenous creatinine clearance of 66ml/min, daily protein excretion of 1.7g. These patients were maintained for eight to 18 months on a diet containing about 40Kcal/kg and 1g/kg of protein. Phosphorous and calcium intake were unrestricted. Group 2 had 32 patients with a mean creatinine clearance of 60ml/min and daily protein excretion of 1.8g. They followed no specific dietary regimen for six to 14 months. Their dietary calorie and protein intakes averaged 30Kcal/kg and 70g respectively. At the end of the observation period creatinine clearance values of Group 1 averaged 74ml/min, the daily protein excretion amounted to 1.1g. Values for Group 2 averaged 53ml/min and 1.9g respectively. Moderate dietary restriction of protein alone results in improving creatinine clearance values and a decreased protein excretion in the early stages of chronic renal failure in patients with glomerulonephritis.
D000328:Adult; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000178:diet therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged
D004044:Dietary Proteins