Sex difference in susceptibility to teratogenic effect of maternal biotin deficiency in mouse embryos.
When pregnant mice were fed biotin-deficient diets, cleft palate occurred more frequently in male fetuses than in female fetuses. Possible underlying mechanisms are speculated on, and some methodological problems in the analysis of sex-related differences in multiparous animals are discussed.
D000818:Animals; D001710:Biotin / Q000172:deficiency*; D002972:Cleft Palate / Q000209:etiology*; D005260:Female; D008297:Male; D051379:Mice; D010298:Parity; D011247:Pregnancy; D012737:Sex Factors
D001710:Biotin