Effect of antidotes of the acute toxicity of methacrylonitrile.
When rats were exposed for 30 min to methacrylonitrile at concentrations between 3180 and 5700 ppm, the clinical symptoms observed suggested a toxic activity of metabolically formed cyanide. This is in contrast to the signs of toxicity observed in the same species after inhalation of acrylonitrile where metabolic cyanide formation plays only a minor role. The acute toxicity of methacrylonitrile could be antagonized with cyanide antidotes (4-dimethylaminophenol plus sodium thiosulfate) as well as with N-acetyl-cysteine which directly reacts with alpha,beta-unsaturated nitriles.
D000179:Acrylates / Q000633:toxicity*; D000181:Acrylonitrile / Q000633:toxicity; D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D003486:Cyanides / Q000378:metabolism; D008297:Male; D008689:Methacrylates / Q000633:toxicity*; D009570:Nitriles / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000179:Acrylates; D000931:Antidotes; D003486:Cyanides; D008689:Methacrylates; D009570:Nitriles; C008385:methacrylonitrile; D000181:Acrylonitrile