Cardiovascular risk factors and cardiovascular death in haemodialysed diabetic patients.
In a retrospective study, causes of death and the cardiovascular risk conferred by established risk factors were analysed in 200 diabetic and 200 matched non-diabetic uraemic patients admitted for haemodialysis. Total and cardiovascular mortality was considerably higher in diabetics, both type I (4.8-fold) and type II (3.0-fold). Fifty-eight per cent of deaths in diabetics, but only 38 per cent of deaths in non-diabetics were due to cardiovascular causes; myocardial infarction and stroke accounted for less than 15 per cent of deaths, the majority being due to sudden death. Cardiovascular death in diabetes was predicted by both history of hypertension and by cardiomegaly, but to a much lesser extent by clinical evidence of macroangiopathy. The results are compatible with an important role of non-coronary cardiomyopathic mechanisms of cardiovascular death in dialysed diabetics.
D002318:Cardiovascular Diseases / Q000209:etiology* / Q000401:mortality; D003928:Diabetic Nephropathies / Q000150:complications*; D005060:Europe; D006801:Humans; D006435:Renal Dialysis; D012189:Retrospective Studies; D012306:Risk