Immune complexes in insulin-dependent diabetes.
Circulating immune complexes (IC) were studied in 40 newly-diagnosed insulin-dependent diabetics (IDDM), 40 long duration IDDM, and 16 healthy controls. IC were detected by the solid-phase Clq test (SP-Clq). IDDM patients at diagnosis (25%) showed a higher incidence of IC compared to the long duration IDDM patients (15%) and the control group (7%). There was no difference in the prevalence of circulating IC in long duration IDDM with clinical nephropathy and those without clinical nephropathy. IC detected by Sp-Clq, seem to be associated with the clinical onset of IDDM but not with the development of nephropathy.
D000328:Adult; D000936:Antigen-Antibody Complex; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003928:Diabetic Nephropathies / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
D000936:Antigen-Antibody Complex