Charge transfer in the mechanism of drug action involving quinoxaline di-N-oxides.
Cyclic voltammetry data were obtained for various 2,3-disubstituted quinoxaline di-N-oxides: dimethyl, bishydroxymethyl, bisacetoxymethyl, bis-N-anilinomethyl, and dicarboxaldehyde hydrate. The dimethyl derivative exhibited the most negative E1/2 value, and along with the diol, showed reversible reduction for the first wave. Rationalizations of the E1/2 values are provided. Reasonable correlations exist for the electrochemical data and drug activity. The results support the diiminium theory of drug action.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004563:Electrochemistry; D004579:Electron Transport; D009153:Mutagens; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009153:Mutagens; D011810:Quinoxalines; C003282:quindoxin