Ketoconazole-induced fulminant hepatitis.
We report the cases of two adult patients in whom fulminant hepatitis developed after 17 and 103 days of ketoconazole administration. Histologic administration showed massive, predominantly centrilobular necrosis. Clinical manifestations of hypersensitivity and eosinophilia were absent in both patients, which suggests that ketoconazole hepatotoxicity is not mediated through an immunoallergic mechanism.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D000410:Alanine Transaminase; D007654:Ketoconazole