Dexamethasone directly inhibits snake venom phospholipase A.
Dexamethasone was found to directly inhibit snake venom phospholipase A2 within 3 to 10 minutes. To detect this effect, the incubation time seems to be critical. Moreover, the inhibitory effect of dexamethasone and mepacrine were additive with each other. We speculate that this direct inhibitory effect on phospholipase A2 plays a part in its strong biological activity.
D000818:Animals; D003435:Crotalid Venoms / Q000032:analysis*; D003907:Dexamethasone / Q000494:pharmacology*; D004357:Drug Synergism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D010713:Phosphatidylcholines / Q000378:metabolism; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011796:Quinacrine / Q000494:pharmacology; D013997:Time Factors
D003435:Crotalid Venoms; D010713:Phosphatidylcholines; D003907:Dexamethasone; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D011796:Quinacrine