title: Cataract surgery following cobalt-60 plaque radiotherapy for posterior uveal malignant melanoma.
abstract: We reviewed the records of thirteen patients with posterior uveal malignant melanoma who had developed a mature radiation cataract following cobalt-60 plaque radiotherapy. Cataract extraction had been performed in seven of these patients as of the survey date of this investigation. We attempted to determine if cataract extraction increased the risk of metastatic melanoma, improved or worsened visual function, or resulted in any consistent intraoperative or postoperative complications that did not occur if the cataract was retained. Our analysis showed that removing the cataract did not appear to increase the risk of death from metastatic melanoma, but it also indicated that cataract extraction did not seem to improve the visual function of the irradiated eye. On the basis of our experience to date, we offer suggested guidelines for the management of patients who develop a mature cataract following cobalt-60 plaque radiotherapy of a posterior uveal malignant melanoma.
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D002386:Cataract / Q000209:etiology; D002387:Cataract Extraction; D003037:Cobalt Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000453:epidemiology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011183:Postoperative Complications; D012306:Risk; D014604:Uveal Neoplasms / Q000532:radiotherapy*
chemical_list: D003037:Cobalt Radioisotopes