Calcitonin deficit syndrome in thyroidectomized patients.
The results of a study carried out on 10 patients who underwent total or subtotal thyroidectomy to determine the effects of a prolonged deficit in calcitonin on bone turnover, are reported. The following parameters were evaluated: serum calcium and phosphate, serum alkaline phosphatase, urinary hydroxyproline, serum iPTH, serum iCT and bone mineral content (BMC) of the distal radius. In ten patients controlled 24 months after surgery, a lowering in circulating iCT levels was noted together with a significant decrease in BMC. These observations while supporting the theory that a CT deficit can determine osteoporosis, suggest that further consideration should be given to substitutive therapies for totally and subtotally thyroidectomized patients.
D001842:Bone and Bones / Q000032:analysis; D002116:Calcitonin / Q000172:deficiency*; D006801:Humans; D008903:Minerals / Q000032:analysis; D010024:Osteoporosis / Q000209:etiology; D011183:Postoperative Complications; D013577:Syndrome; D013965:Thyroidectomy / Q000009:adverse effects*
D008903:Minerals; D002116:Calcitonin