A mathematical analysis of aging influences on enzyme deactivation/activation kinetics. Examples of the influence of regional brain development and drugs in rats.
A series-type enzyme deactivation/activation model involving active enzyme states is utilized to theoretically quantify the influence of regional brain development and drugs on enzyme activity levels in rats. Continuous hexachlorobenzene administration with, or without, phenobarbitone pretreatment has different effects on the deactivation/activation kinetics of porphyrinogen carboxylase, delta-aminolaevulinate synthase and delta-aminolaevulinate dehydratase. The deactivation/activation kinetics exhibited by pyruvate dehydrogenase, citrate synthase, and D-3-hydroxybutyrate dehydrogenase during the development of the medulla oblongata, mid-brain, striatum, and hypothalamus sections exhibit similarities as well as discrepancies. These are identified and made more quantitative.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000375:Aging; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006581:Hexachlorobenzene / Q000494:pharmacology; D008954:Models, Biological; D010088:Oxidoreductases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D006581:Hexachlorobenzene; D010088:Oxidoreductases; D000624:5-Aminolevulinate Synthetase; D002262:Carboxy-Lyases; C022430:porphyrinogen carboxy-lyase; D010634:Phenobarbital