The radiation chemistry of some platinum-containing radiosensitizers and related compounds.
Oxidation and reduction of cis- and trans-dichlorodiammine platinum II (cis- and trans-PDD), cis-dichlorobis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole-N3)-p latinum II (cis-Flap), and cis-dichlorobis(isopropylamine)-trans-dihydroxyplatinum IV (Chip) have been studied using pulse radiolysis. Spectra corresponding to platinum in various oxidation states have been observed and several rate constants have been obtained. Reduction of all the compounds, except cis-Flap, produces species of a lower oxidation state of platinum which subsequently have both chloride ligands replaced. Ultimately, these products disproportionate. In the case of cis-Flap, reduction occurred on the nitroimidazole ligand. This was verified by the absence of platinum metal after disproportionation. Oxidation of all four compounds consists of production of a higher oxidation state of platinum followed by replacement of chloride ligands and finally disproportionation of the products. Only cis-Flap and Chip could be reduced by oxidized DNA bases. The one-electron reduction potential of cis-Flap was found to be -370 +/- 10 mV. trans-Flap had almost the same value. It was not possible to measure the potentials of the other compounds since their ligands were replaced rapidly but it is estimated that the one-electron reduction potentials decrease in the order cis- or trans-Flap greater than Chip greater than cis-PDD greater than trans-PDD.
D000970:Antineoplastic Agents / Q000528:radiation effects*; D002588:Cesium Radioisotopes; D002945:Cisplatin / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D007536:Isomerism; D008795:Metronidazole / Q000031:analogs & derivatives / Q000528:radiation effects; D009944:Organoplatinum Compounds / Q000528:radiation effects*; D010084:Oxidation-Reduction; D011675:Pulse Radiolysis; D011838:Radiation-Sensitizing Agents / Q000528:radiation effects*
D000970:Antineoplastic Agents; D002588:Cesium Radioisotopes; D003037:Cobalt Radioisotopes; D009944:Organoplatinum Compounds; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; C034697:transplatin; C023359:iproplatin; C036789:dichlorobis(1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole)platinum (II); D002945:Cisplatin