title: [Pathophysiological investigations on the function of artificial hearts].
abstract: The mode of action of artificial hearts is in a wide range variable and to be adapted to different conditions of the circulatory systems. The direct regulative function of the peripheral circulation is restricted by the rigid ability of artificial hearts bound to motor drive parameters. Their great dependence on pre- and afterload already in normal calves presumes a harmonized functional capacity of the right and left ventricle. As to the situation in potential recipients of artificial hearts with considerably disturbed macro- and microhaemodynamics there are problems for the choice of suitable conditions of motor drive, in order to favour a right-left balance and an adequate volume. The substitution of the natural regulators by suitable sensors and the regulation of the artificial hearts according to haemodynamic controls and pump parameters, respectively, is necessary to achieve a balanced adequate ventricular function. This complex is subject of an intensive research.
mesh_terms: D000818:Animals; D001187:Artificial Organs; D002417:Cattle; D006321:Heart / Q000502:physiology / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D012016:Reference Values; D013318:Stroke Volume; D016276:Ventricular Function
vernacular_title: Pathophysiologische Betrachtungen zur Funktion künstlicher Herzen.