[Reperfusion damages to the heart in acute transitory coronary failure and their prevention with myophedrin].
Experiments were made on 56 white noninbred male rats with transitory coronary insufficiency (duration of myocardial ischemia 10, 40 and 120 min, the length of subsequent reperfusion 10 and 40 min). It was discovered that there were changes in the ultrastructure of cardiocytes and vessels of the microcirculatory bed both in the area of ischemia and reperfusion and in the distant heart regions, an increase in myocardial cell and microvessel lesions during postischemic reperfusion not only in the area of ischemia but also in distant zones. In addition, a reduction was noted in the degree of ischemic and reperfusion myocardial injury during the prophylactic use of myophedrine. The mechanisms of the protective action of myophedrine in acute transitory coronary insufficiency are discussed.
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003326:Coronary Circulation; D003327:Coronary Disease / Q000188:drug therapy / Q000473:pathology*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D010099:Oxyfedrine / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*; D051381:Rats; D013997:Time Factors
D002317:Cardiovascular Agents; D011427:Propiophenones; D010099:Oxyfedrine
Reperfuzionnye povrezhdeniia serdtsa pri ostroĭ tranzitornoĭ koronarnoĭ nedostatochnosti i ikh preduprezhdenie miofedrinom.