title: Similarity of effects--experimental hyperthermia as a teratogen and maternal febrile illness associated with oromandibular and limb defects.
abstract: Experimental hyperthermia in pregnancy causes oromandibular and limb anomalies. In humans, hyperthermia has been suspected of being teratogenic. Two patients were investigated; both had limb defects and one had oromandibular anomalies. Their mothers had a febrile illness at about the 10th wk of gestation. The similarity of defects produced by experimental hyperthermia and those reported here is striking.
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology*; D000328:Adult; D000818:Animals; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000150:complications*; D006801:Humans; D006979:Hyperthermia, Induced; D007223:Infant; D017880:Limb Deformities, Congenital; D008297:Male; D008334:Mandible / Q000002:abnormalities*; D009056:Mouth Abnormalities / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications