[Toxicological characteristics of acute and subacute T-2 mycotoxicosis in mice].
Intragastric administration to mice of solutions of crystalline T-2 toxin in a dose aqual to the LD50 or in doses from the 1/5 to 1/50 of the LD50 brought about a stable decrease in alkaline phosphatase activity and lysozyme concentration in blood serum. In addition, acute and subacute T-2 mycotoxicoses were characterized by a marked lowering of hemoglobin concentration, the total red cell and leukocyte counts (doses 1/5-1/20 of the LD50) and lymphosytes (doses 1/5-1/50 of the LD50) in the peripheral blood toward the end of experiments. Variation of the hematological and biochemical characteristics after administering the toxin in low doses was detected despite the absence of the clinical symptoms of intoxication. These characteristics are the most sensitive to the toxic action of T-2 toxin.
D000208:Acute Disease; D000818:Animals; D001769:Blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000506:poisoning / Q000633:toxicity*; D013997:Time Factors
D012717:Sesquiterpenes; D013605:T-2 Toxin
Toksikologicheskaia kharakteristika ostrogo i podostrogo T-2 mikotoksikozov u mysheĭ.