The effect of indomethacin treatment on lymphocyte PHA reactivity in healthy controls and patients with lymphoma and sarcoidosis.
Lymphocytes from healthy volunteers who took indomethacin orally for 3 d showed an enhanced in vitro response to phytohaemagglutinin (PHA). When indomethacin was added in vitro, lymphocytes from healthy controls showed similar but more consistent increases of PHA responses than lymphocytes from patients with sarcoidosis or lymphoma. Moreover, the enhancing effect of indomethacin was by and large more pronounced in those patients who had relatively normal PHA lymphocyte responses in the absence of indomethacin, and the presence of indomethacin failed in most instances to increase subnormal responses to normal control levels. These findings are not consistent with the notion that increased prostaglandin synthesis is the principal cause of subnormal PHA reactivity of lymphocytes from patients with sarcoidosis or lymphoma.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000188:drug therapy / Q000276:immunology*
D007213:Indomethacin