Karyotypic evolution in multiple myeloma.
A patient with IgG kappa multiple myeloma was studied cytogenetically prior to therapy and was found to have a clone of 55,XX cells. After treatment leading to a clinical response, the patient relapsed with a clone of 57,XX cells, which were derivatives of the original neoplastic cell line. This is the first case of demonstrated clonal evolution of myeloma in a patient studied prior to chemotherapy.
D000368:Aged; D000782:Aneuploidy; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002999:Clone Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D013997:Time Factors; D014314:Trisomy