Effect of oxygen concentration on cellular metabolism.
Experimental evidence is presented that mitochondrial oxidative phosphorylation is dependent on oxygen concentration in its physiologic range both in vivo and in vitro. Mitochondrial oxidative phosphorylation is considered to act as a tissue oxygen sensor important for controlling local vascular resistance.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D008928:Mitochondria / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010100:Oxygen / Q000378:metabolism*; D012377:Rodentia; D014655:Vascular Resistance
D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D010100:Oxygen