title: [The f-factor (fat infiltration) in breast cancer as a new indicator for predicting the occurrence of bone metastasis].
abstract: The correlation between tumor infiltration into extramammary fatty tissues (f-factor) and bone metastasis was retrospectively analyzed in 117 patients with breast cancer. Five (10.6%) and 26 (37.1%) patients developed bone metastases among 47 f-negative and 70 f-positive subjects, respectively, and the frequency of bone metastasis was significantly higher in the f-positive than in the f-negative group (p less than 0.005). Furthermore, bone metastasis was more frequent in the f-positive than in the f-negative group among patients of the same stages, lymph node involvements, or histological types. The f-factor was suggested to be a new indicator for predicting the occurrence of bone metastasis in breast cancer.
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness