Temperature and histamine receptor function--what is really happening?
Early studies suggested that a low temperatures there was a transition of receptor type from an H1 to an H2 receptor when the temperature was reduced from 37 degrees C to temperatures below 20 degrees C. These original observations were based on the development of sensitivity of guinea-pig ileum to the H2 antagonist metiamide as the temperature was reduced. More recently, evidence from a number of laboratories has cast doubt on the existence of a simple H1-H2 receptor transition, but there is abundant evidence that there are major changes in the response of a variety of smooth muscle preparations to histamine at reduced temperatures. The evidence in regard to alterations in histamine response at low temperatures is reviewed, some new evidence presented, and a model which is consistent with most of the observations is suggested.
D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology; D003106:Colon / Q000502:physiology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000502:physiology; D066298:In Vitro Techniques; D008785:Metiamide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology*; D011968:Receptors, Histamine / Q000502:physiology*; D013696:Temperature
D011968:Receptors, Histamine; D008785:Metiamide; D002744:Chlorpheniramine; D006632:Histamine