title: Serum creatine kinase after intramuscular injections.
abstract: Serum creatine kinase (CK) activity was measured after intramuscular injections in 44 patients hospitalized for non-cardiac reasons. The drugs injected were: diazepam, dipyrone, metoclopramide, meperidine, pentazocine and procaine penicillin. Only 3 out of 44 patients (7%) demonstrated significant elevation of CK levels following the intramuscular injections. In these 3 patients the elevation was mainly due to a rise of the MM-isoenzyme fraction with MB levels increased in one patient. These findings do not justify the common clinical notion of regarding intramuscular injections as a frequent cause of serum CK elevation. It is concluded that high CK serum values in a patient with chest pain should always be considered with utmost suspicion, disregarding the possible effects of a previous intramuscular injection.
mesh_terms: D000328:Adult; D000368:Aged; D003402:Creatine Kinase / Q000097:blood*; D003975:Diazepam / Q000494:pharmacology; D004177:Dipyrone / Q000494:pharmacology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008614:Meperidine / Q000494:pharmacology; D008787:Metoclopramide / Q000494:pharmacology; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects*; D010402:Penicillin G Procaine / Q000494:pharmacology; D010423:Pentazocine / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010402:Penicillin G Procaine; D004177:Dipyrone; D008614:Meperidine; D003402:Creatine Kinase; D008787:Metoclopramide; D003975:Diazepam; D010423:Pentazocine