Pyridoxine for neonatal seizures: an unexpected danger.
A case of pyridoxine-dependent seizures is reported. Administration of pyridoxine to an infant after a long period of convulsions was followed by acute hypotonia. Other cases have been reported in the literature, in one of which assisted ventilation was required. A possible mechanism for this alarming outcome is discussed, and it is suggested that resuscitation facilities should be quickly available during such trials.
D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009123:Muscle Hypotonia / Q000139:chemically induced; D011736:Pyridoxine / Q000009:adverse effects* / Q000627:therapeutic use; D013036:Spasms, Infantile / Q000188:drug therapy*
D011736:Pyridoxine