Distribution and chromatographic characterization of neuromedin B-like immunoreactivity in the human spinal cord.
The quantitative regional distribution of neuromedin B-like immunoreactivity in normal postmortem human spinal cord was studied by a specific radioimmunoassay. Neuromedin B-like immunoreactivity was found in highest concentration in the dorsal part of the sacral cord. Chromatographic analyses by gel permeation and reverse-phase high-pressure liquid chromatography revealed two major peaks of neuromedin B-like immunoreactivity and the prevalent molecular form, approx. 90% of the total immunoreactivity, was chromatographically identical to synthetic porcine neuromedin B.
D000368:Aged; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D015287:Neurokinin B / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000032:analysis*; D011863:Radioimmunoassay; D013116:Spinal Cord / Q000032:analysis*
D009419:Nerve Tissue Proteins; D009842:Oligopeptides; D015287:Neurokinin B; C038393:neuromedin B