Liposomal cholesterol binding to steroid-free cytochrome P450scc: effects of fatty acyl and head groups in phospholipids.
The effects of fatty acyl substituents and head groups of phospholipids on the liposomal cholesterol transfer to steroid-free cytochrome P450scc were examined as a model system for ACTH-enhanced availability of cholesterol to the cytochrome in the inner membrane of adrenal cortex mitochondria. It was implicated that using a variety of saturated and unsaturated phospholipids fatty acyl groups play an important role in the transfer reaction.
D002308:Cardiolipins; D002784:Cholesterol; D003577:Cytochrome P-450 Enzyme System; D005227:Fatty Acids; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010743:Phospholipids; D013109:Sphingomyelins; D013329:Structure-Activity Relationship
D002308:Cardiolipins; D005227:Fatty Acids; D008081:Liposomes; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010743:Phospholipids; D013109:Sphingomyelins; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol