Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture.
Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with 1 M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. et al. Jpn. J. Bone Metab., 2, 231-235 (1984)]. This study showed that CATF inhibited the proliferation and DNA synthesis of endothelial cells isolated from bovine pulmonary artery, but not the proliferations of sarcoma 180, L1210 and L cells. These results suggest that CATF has anti-angiogenic properties, thereby inhibiting the growth of solid tumors.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002356:Cartilage / Q000502:physiology*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D004727:Endothelium / Q000166:cytology; D007700:Kinetics; D007739:L Cells / Q000166:cytology; D007939:Leukemia L1210 / Q000473:pathology; D011651:Pulmonary Artery / Q000166:cytology*; D012510:Sarcoma 180 / Q000473:pathology; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014020:Tissue Extracts