Nocardia asteroides infection with dissemination to skin and joints.
A 56-year-old diabetic woman developed multiple cutaneous lesions and septic arthritis secondary to disseminated Nocardia asteroides pulmonary infection. The diagnosis was made rapidly by Gram's and acid-fast stains of pus, sputum, and synovial fluid and later confirmed by cultures. Sulfonamides are the drugs of choice for nocardiosis, and this patient had a complete response to two weeks of intravenous trimethoprim and sulfamethoxasole followed by three months of oral therapy.
D001170:Arthritis, Infectious / Q000188:drug therapy* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007596:Joints / Q000473:pathology; D008171:Lung Diseases / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009617:Nocardia Infections / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage
D014295:Trimethoprim; D013420:Sulfamethoxazole