title: Meso and racemic organisms and the transition to asymmetry.
abstract: In this paper we analyse extensive but previously unappreciated and scattered data on anomalous enzyme modulation by metabolite enantiomers for enzymes in the principle metabolic cycles and develop a coherent theory for their derivation from reciprocally coupled antipodal metabolisms in antecedent meso and racemic organisms. Structures for such chirally symmetric organisms are outlined, as is the gradual decoupling of their integrated antipodal metabolisms upon an evolutionary progression from meso organism to racemic organism to racemate of organisms. The driving forces and the dynamics for a transition to asymmetry are developed.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002952:Citric Acid Cycle; D004798:Enzymes / Q000378:metabolism*; D005246:Feedback; D005994:Glycerophosphates / Q000378:metabolism; D006038:Glyoxylates / Q000378:metabolism; D007536:Isomerism; D008968:Molecular Conformation; D009249:NADP / Q000096:biosynthesis; D014508:Urea / Q000378:metabolism
chemical_list: D004798:Enzymes; D005994:Glycerophosphates; D006038:Glyoxylates; D009249:NADP; D014508:Urea