[Inhibition of macrophage phagocytic activity by selective sensitization to alloantigens of the H-2 system].
The action exerted by selective sensitizations to alloantigens coded by the Major Histocompatibility System of the mouse, H-2, on the phagocytic ability of the mouse peritoneal macrophages has been studied. The results suggest that when immunizations are performed between completely incompatible animals for the H-2k haplotype, after the third immunization the total number of macrophages able to carry out phagocytosis decreases very significantly. When the incompatibilities, however, are due to the left half of the H-2 system or to minor histocompatibility antigens, such an inhibition does not appear.
D000818:Animals; D006183:H-2 Antigens / Q000276:immunology*; D007114:Immunization; D007519:Isoantigens / Q000276:immunology*; D008264:Macrophages / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008912:Minor Histocompatibility Loci; D010587:Phagocytosis
D006183:H-2 Antigens; D007519:Isoantigens
Inhibición de la actividad fagocítica de macrófagos por sensibilización selectiva a aloantígenos del sistema H-2.