Catecholaminergic fiber sprouting in granuloprival coeruleo-cerebellar cultures.
Neonatal mouse coeruleo-cerebellar explants exposed to cytosine arabinoside to destroy granule cell precursors demonstrated sprouting of catecholaminergic fibers after 15 days in vitro. Levels of dopamine in granuloprival coeruleo-cerebellar cultures were more than twice those of control cultures. As granuloprival cerebellar cultures also demonstrate Purkinje cell axon collateral sprouting, the granuloprival coeruleo-cerebellar system, in which there is sprouting of two different neuronal groups, may provide a model to investigate the nature and specificity of the signal or signals that induce axonal sprouting.
D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism*; D002531:Cerebellum / Q000166:cytology* / Q000378:metabolism; D003561:Cytarabine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D006651:Histocytochemistry; D008125:Locus Coeruleus / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D009412:Nerve Fibers / Q000378:metabolism / Q000502:physiology*; D009924:Organ Culture Techniques; D013997:Time Factors
D002395:Catecholamines; D003561:Cytarabine; D004298:Dopamine