title: Falsely elevated digoxin concentrations in patients with liver disease.
abstract: Immunoreactive digoxin was determined in blood samples of 73 patients with liver disease who did not take any cardiac glycoside. Seventeen of these patients reproducibly showed false-positive results, as much as 3.6 ng/ml. Patients with concomitant renal disease had higher assay results (mean 1.9 n/ml) than patients with normal renal function (mean 0.6 ng/ml). It is concluded that blood of a number of patients with liver disease of different causes contains a substance that interferes with digoxin radioimmunoassay.
mesh_terms: D000328:Adult; D000368:Aged; D004077:Digoxin / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011933:Reagent Kits, Diagnostic
chemical_list: D011933:Reagent Kits, Diagnostic; D004077:Digoxin