[Intra-arterial chemotherapy of ORL tumors. 10 years' experience in the Antoine-Lacassagne Center].
One hundred and two patients with malpighian epithelioma of ORL origin were treated with intra-arterial chemotherapy (IAC) as initial therapy, followed by either surgery, radiotherapy or a combination of the two. Regression in tumor size of more than 50% was noted in 46% of cases, the introduction of cisplatin into the multiple system chemotherapy providing a response in 71% of the 42 patients treated in this way. A response to induction IAC is a factor of good prognosis as shown by the improvement in level of local and regional extensions and the probability rate of survival in responders. Technical and methodologic progress has made IAC a simple and effective procedure, and its place in the treatment of epitheliomas of head and neck should be established more precisely.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002277:Carcinoma / Q000188:drug therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000188:drug therapy*; D013223:Statistics as Topic; D013997:Time Factors
D000970:Antineoplastic Agents
Chimothérapie intra-artérielle des tumeurs ORL. 10 ans d'expérience au Centre Antoine-Lacassagne.