Stimulation of tyrosine phosphorylation of rat brain membrane proteins by calmodulin.
Calmodulin stimulates the alkali-resistant phosphorylation of peptides of 50 and 58-60 kDa in rat brain membrane. Phosphoamino acid analysis indicated a calmodulin stimulated increase of phosphotyrosine in these peptides. Calmodulin also stimulated the phosphorylation of these peptides at serine and threonine residues. This suggests the involvement of the calmodulin regulatory system in the effects of tyrosine protein kinases.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000201:enzymology*; D002147:Calmodulin / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D051381:Rats
D000596:Amino Acids; D002147:Calmodulin; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011505:Protein-Tyrosine Kinases