[Methodological approaches to assessing the effectiveness of anti-angina preparations in stenocardia patients using paired bicycle ergometry loads].
Paired bicycle ergometry was used in 24 anginal patients to compare the efficiency of 10-20 mg isosorbide dinitrate, 20-30 mg corinfar and 40-80 mg propranolol. Isosorbide dinitrate showed maximum efficiency in half of the patients, corinfar in 1/4, propranolol in 1/6. Isosorbide dinitrate produced an effect with the very first dose more frequently, as compared to other drugs. Heart rate patterns at rest and under the action of corinfar and isosorbide dinitrate varied in different individuals and were related to the time of onset of an exercise-induced anginal attack.
D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000379:methods; D005080:Exercise Test / Q000379:methods; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D010807:Physical Endurance / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use
D002317:Cardiovascular Agents; D011433:Propranolol; D009543:Nifedipine; D007548:Isosorbide Dinitrate
Metodicheskie podkhody k otsenke éffektivnosti antianginal'nykh preparatov u bol'nykh so stenokardieĭ s pomoshch'iu parnykh veloérgometricheskikh nagruzok.