A comparison of in vivo and in vitro amphetamine on the synaptosomal uptake of dopamine in mouse striatum.
Amphetamine (AMPH) produced competitive uptake inhibition of 3H-dopamine (DA) in synaptosomes obtained from mouse striatum--whether it was injected beforehand into living animals or simply added to the incubation medium. However, the in vivo drug doses required to produce this effect were high (ED50 = 65 mg/kg.) as compared with the in vitro doses (ED50 = 2.5 X 10(-6) M).
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013574:Synaptosomes / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D000661:Amphetamine; D004298:Dopamine