Cholecystokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain.
An antiserum specific for the amino terminus of pro-CCK detects 3 major peptides in rat brain with molecular weights of 13,000, 8000 and 2700 daltons. These peptides are abundant both in CCK terminal-field regions and regions rich in CCK perikarya. The two high molecular weight peptides probably represent CCK precursor molecules. The smaller peptide is probably the amino-terminal fragment of pro-CCK and may be stored and released along with CCK-8, and have a potential role in synaptic transmission.
D000818:Animals; D001923:Brain Chemistry; D002766:Cholecystokinin / Q000032:analysis*; D008722:Methods; D008970:Molecular Weight; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D002766:Cholecystokinin