Effects of naloxone and chlordiazepoxide on lateral hypothalamic self-stimulation in rats.
Lateral hypothalamic self-stimulation behavior of rats in an operant chamber was investigated under the treatments of the first injection of naloxone (5 mg/kg) or saline followed by the second injection of chlordiazepoxide (4 mg/kg) or saline. Both inhibitory effect of naloxone and facilitatory effect of chlordiazepoxide on self-stimulation response were statistically significant, but the interaction between the two effects was not obtained. The results indicate that the facilitatory effect of chlordiazepoxide upon self-stimulation is independent of endogenous opioid system. Further, the obtained effect of naloxone was discussed in terms of interaction of the drug with aversive, rather than rewarding, component of self-stimulation.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D004723:Endorphins / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology
D004723:Endorphins; D009270:Naloxone; D002707:Chlordiazepoxide