Clearance of 3H-dopamine from the amniotic fluid in the rhesus monkey.
Previous studies have suggested that dopamine is the major catecholamine in the amniotic fluid; however, there are few data available concerning the metabolism of this hormone in the amniotic fluid compartment. With the use of acute 3H-dopamine injection studies into the amniotic sac of pregnant rhesus monkeys, the dopamine half-life was observed to be 29 minutes, the amniotic fluid volume was 113 ml, the metabolic clearance rate was 164 ml/hr, and the calculated production rate was 436 ng/hr. The biphasic pattern of dopamine clearance from this compartment suggests that it is cleared from the amniotic sac by mechanisms similar to those used in the intravascular compartment.
D000653:Amniotic Fluid / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D008253:Macaca mulatta; D008657:Metabolic Clearance Rate; D011247:Pregnancy
D004298:Dopamine