Effect of FUT-175, a new synthetic protease inhibitor, on the development of lupus nephritis in (NZB x NZW) F1 mice.
FUT-175 (6-amidino-2-naphthyl p-guanidinobenzoate dimethanesulphonate), a new synthetic protease inhibitor, was administrated to (NZB x NZB) F1 mice in order to examine its influence on the development of autoimmune diseases. A dose (400 mg/kg of body weight) of FUT-175 has both prophylactic and curative effects on the development of lupus nephritis: mice showed a significantly low percentage of proteinuria, a marked decrease in BUN levels, and the lowest degree of glomerular damages. Dexamethasone had almost the same effect as FUT-175 (400 mg/kg), but it was slightly less effective than FUT-175. These results suggest that the administration of FUT-175 may become a viable strategy for the treatment of human autoimmune diseases.
D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000517:prevention & control; D001550:Benzamidines; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000517:prevention & control; D006146:Guanidines / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000517:prevention & control; D051379:Mice; D008815:Mice, Inbred Strains; D009780:Occult Blood; D011507:Proteinuria / Q000188:drug therapy
D001550:Benzamidines; D006146:Guanidines; C032855:nafamostat