Effects of H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH on different behavioral tests of rats.
H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH inhibited the extinction of active avoidance behavior 3 h and 6 h after administration and facilitated the learning of a T-discrimination task. The peptide antagonized ECS-induced amnesia, if the treatment was performed 1 h before the test session. These results suggest that H-Phe-Ile-Tyr-His-Ser-Tyr-Lys-OH can facilitate learning and memory processes.
D000647:Amnesia / Q000188:drug therapy*; D000648:Amnesia, Retrograde / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004597:Electroshock; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D009842:Oligopeptides; C036810:H-phenylalanyl-isoleucyl-tyrosyl-histidyl-seryl-tyrosyl-lysine