Tissue distribution, urinary, fecal and biliary excretion of 14C bendazac L-lysine salt in rats.
The distribution of bendazac in the plasma and some rat tissues was studied after single oral administration of 14C bendazac L-lysine salt. The drug is distributed in varying amounts in the liver, kidneys, spleen, muscle, plasma and lens. In these tissues, the drug kinetics is similar, except for the lens where elimination of the drug is slower. More than 80% of the radioactivity administered is excreted through the urine and feces. Fecal excretion is due to the high biliary excretion.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism* / Q000652:urine; D001646:Bile / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D007191:Indazoles / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D007908:Lens, Crystalline / Q000378:metabolism; D008297:Male; D011720:Pyrazoles / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors; D014018:Tissue Distribution
D000893:Anti-Inflammatory Agents; D007191:Indazoles; D011720:Pyrazoles; C036067:bendazac lysine