Pancreatic oncofetal antigen in the detection of experimental cancer of the pancreas.
A hamster serum protein which reacted with anti-human pancreatic oncofetal antigen (POA) was identified in sera from hamsters with varying types of pancreatic pathology. Hamsters were treated with N-nitrobis-(2-hydroxypropyl)-amine, and histological findings in the pancreas were correlated with hamster POA. The cross reactivity of anti-human POA with hamster POA was poor. As a result, the sensitivity of this assay was too low to permit its use in serologically discriminating carcinogen-induced pancreatic cancer from other pancreatic pathologies. A specific antiserum and assay system to hamster POA may overcome this problem.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000276:immunology
D000951:Antigens, Neoplasm; C031192:oncofetal antigens