title: [Fatal poisoning by the retard form of verapamil. Therapeutic considerations].
abstract: A 60-year-old woman swallowed 2.4 g verapamil in a retard form (Isoptin retard). Depsite intensive efforts she died 44 hours later in a coma due to circulatory collapse. In contrast to other reported cases of poisoning, the verapamil concentration in plasma continued to rise. This atypical course with continuing absorption of verapamil was due to small-intestinal deposits of the drug, found at autopsy.
mesh_terms: D003128:Coma / Q000139:chemically induced; D003692:Delayed-Action Preparations / Q000506:poisoning; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000032:analysis; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D013405:Suicide; D014018:Tissue Distribution; D014700:Verapamil / Q000032:analysis / Q000506:poisoning*
chemical_list: D003692:Delayed-Action Preparations; D014700:Verapamil
vernacular_title: Tödliche Vergiftung mit Verapamil in Retard-Form. Therapeutische Uberlegungen.