Administration of ketoprofen suppositories for out-patient post-operative analgesia.
A double-blind, randomized, placebo-controlled study was carried out to assess the efficacy of ketoprofen suppositories as a post-operative analgesic in out-patients undergoing extirpation surgery. Thirty patients received 2 X 100 mg ketoprofen suppositories, and 30 patients received placebo suppositories 1-hour pre-operatively. Patients received no premedication and the anaesthetic used was intravenous diazepam and ketamine administered by intravenous drip according to the patient's need. Subjective symptoms of pain were evaluated 15, 30, 60 and 90 minutes post-operatively. None of the patients who received ketoprofen complained of post-operative pain, whereas the patients on placebo showed varying degrees of pain. The only side-effects recorded were nausea and vomiting both in ketoprofen and placebo-treated patients and these were probably related to the anaesthetic.
D000232:Adenofibroma / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D001943:Breast Neoplasms / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008206:Lymphatic Diseases / Q000601:surgery; D010146:Pain / Q000517:prevention & control*; D010666:Phenylpropionates / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication / Q000379:methods*; D011897:Random Allocation; D013488:Suppositories; D013997:Time Factors
D010666:Phenylpropionates; D013488:Suppositories; D007660:Ketoprofen