[Energy support and the contractile capacity of glycerinized myocardial fibers in experimental informational neurosis].
Experiments in dogs revealed that in informational neurosis the ability of myocardial contractile protein system (myocardial glycerinized filament bundles) to develop tension and produce work as well as the power of the contractile process are considerably reduced. Obviously, the energy production is not disturbed as a lower myocardial content of ATP (by 12%) and particularly of CP (by 54%) is caused by 8-9-month hypokinesia. Analogous shifts seem to occur in the human heart in informational neurosis which, in combination with the reduced intensity of the calcium transport by sarcoplasmic reticulum and mitochondria, may underlie the development of heart weakness.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003214:Conditioning, Classical / Q000502:physiology; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D009124:Muscle Proteins / Q000378:metabolism; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D009497:Neurotic Disorders / Q000209:etiology / Q000378:metabolism*; D013997:Time Factors
D009124:Muscle Proteins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D005990:Glycerol
Energeticheskaia obespechennost' i sokratitel'naia sposobnost' glitserinizirovannykh volokon miokarda pri éksperimental'nom informatsionnom nevroze.