Regulatory effect of hydrocortisone on the in vitro synthesis of IgE by human lymphocytes.
The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogen-driven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10(-7)-10(-4) M), and the second is inhibition of synthesis by higher concentrations due to lymphocytotoxic effect.
D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D011043:Pokeweed Mitogens / Q000494:pharmacology
D007074:Immunoglobulin G; D011043:Pokeweed Mitogens; D007073:Immunoglobulin E; D006854:Hydrocortisone