Chromosomal studies in familial polyposis coli.
A study of five patients with familial polyposis coli did not demonstrate any structural abnormalities of prometaphase chromosomes from methotrexate synchronized peripheral blood lymphocytes. No chromosomal heritable fragile sites were observed, nor was sister chromatid exchange increased.
D000328:Adult; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D003110:Colonic Neoplasms / Q000235:genetics*; D003111:Colonic Polyps / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D012854:Sister Chromatid Exchange