title: Rapid microchemical identification of four phenothiazine antiemetics with gold bromide and iodine-potassium iodide reagents: collaborative study.
abstract: A microchemical method was developed for the rapid identification of 4 phenothiazine antiemetics. Perphenazine, promethazine, thiethylperazine, and triflupromazine were positively identified and differentiated with the aid of a gold bromide reagent and an iodine-potassium iodide reagent. Only promethazine and triflupromazine yielded microcrystalline derivatives with gold bromide; only perphenazine and thiethylperazine reacted with iodine-potassium iodide. For each pair of positive reactions, the crystalline products were morphologically distinguishable under a microscope. The 2 tests were collaboratively studied by 7 independent laboratories and found to be simple, rapid, and effective for identifying the phenothiazines of interest. The method has been adopted official first action.
mesh_terms: D000932:Antiemetics / Q000032:analysis*; D003460:Crystallization; D007202:Indicators and Reagents; D007455:Iodine; D008832:Microchemistry; D010640:Phenothiazines / Q000032:analysis*; D011193:Potassium Iodide
chemical_list: D000932:Antiemetics; D007202:Indicators and Reagents; D010640:Phenothiazines; D011193:Potassium Iodide; D007455:Iodine