Brain manganese, catecholamine turnover, and the development of startle in rats prenatally exposed to manganese.
Manganese (Mn) can be neurotoxic when present in high concentrations. Neonatal animals show differential absorption, accumulation, and excretion of Mn relative to adults. If similar kinetic differences exist during gestation, then fetal animals may be susceptible to Mn neurotoxicity. The objective of this study was to examine maternal-fetal Mn transfer and the susceptibility of prenatal animals to Mn neurotoxicity. This was approached by studying the ability of Mn to cross the placenta and reach the fetal central nervous system using radiotracer and atomic absorption spectroscopy techniques. Manganese is thought to disrupt catecholamine neurotransmission in the central nervous system. This was examined in newborn rats by alpha-methyl-para-tyrosine induced catecholamine turnover and the development of the acoustic startle response. The results suggest that there are limits on fetal Mn accumulation under conditions of both normal and excessive dietary Mn levels. Manganese accumulation in the fetal brain after exposure to increased dietary Mn does not alter either dopamine or norepinephrine turnover or the development of the acoustic startle response. Excess Mn does not appear to be neurotoxic to fetal rats in spite of its limited accumulation in nervous tissue after gestational exposure.
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology*; D020149:Manganese Poisoning; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011868:Radioisotopes; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*; D013057:Spectrum Analysis / Q000379:methods; D013997:Time Factors
D002395:Catecholamines; D011868:Radioisotopes; D008345:Manganese