Effects of intravenous ritodrine on lactate and pyruvate levels: role of glycemia and anaerobiosis.
The role of glycemia in ritodrine-induced hyperlactatemia was assessed by measuring lactate and pyruvate levels and studying glycemia in patients treated with intravenous ritodrine for premature labor. Lactate levels were increased moderately by ritodrine and paralleled the levels of glucose; a similar parallelism also was observed in the glucose-administration group. Pyruvate levels also changed in proportion to lactate levels in this latter group, whereas in patients given ritodrine, pyruvate changed little and the lactate/pyruvate ratio was increased. These findings are discussed in terms of possible metabolic and vasopressor consequences of beta-adrenergic stimulation, with emphasis on the potential roles of increased glycemia and anaerobiosis.
D000693:Anaerobiosis / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008660:Metabolism / Q000187:drug effects*; D007752:Obstetric Labor, Premature / Q000097:blood / Q000517:prevention & control*; D011247:Pregnancy; D011412:Propanolamines / Q000627:therapeutic use*; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid; D012312:Ritodrine / Q000627:therapeutic use*
D001786:Blood Glucose; D007773:Lactates; D011412:Propanolamines; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D012312:Ritodrine