The effect of an aqueous horse-radish extract, applied as such or in association with caffeine, on experimental influenza in mice.
An aqueous horse-radish extract was repeatedly administered to mice by intranasal (i.n.) route prior to i.n. inoculation of influenza virus A/PR8/34 (H1N1). The antiviral effect of the extract--also demonstrated in vitro--was reflected by a significant decrease in the hemagglutination titers recorded in mouse lung homogenates and by a slight increase in the mean survival time of treated mice versus untreated controls. Association of horse-radish extract with caffeine led to a synergic effect only as regards the mortality rate.
D000818:Animals; D002110:Caffeine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000401:mortality; D010936:Plant Extracts / Q000627:therapeutic use*; D012996:Solutions; D013997:Time Factors
D010936:Plant Extracts; D012996:Solutions; D002110:Caffeine