title: Effects of changes in abdominal pressure on left ventricular performance and regional blood flow.
abstract: Many clinical conditions are associated with an increase in abdominal pressure. While the effects on venous return have been studied in the past, little attention has been given to the effect of abdominal pressure on left-sided hemodynamic events. The effects of acute changes in abdominal pressure (Pab) on left ventricular (LV) hemodynamics and outflow distribution were evaluated in ten open-chest dogs, which had undergone right heart bypass to eliminate the influence of changes in Pab on systemic venous return. Pressures were measured in the left atrium (Pla), aorta (Pao), and stomach (Pab). Electromagnetic flow probes were positioned around the ascending aorta (Qaa), descending aorta (Qda) and the innominate or subclavian artery (Qin) to reflect total cardiac output and the respective regional caudad and cephalad blood flows. Compressing the abdomen to increase acutely Pab (9.2 +/- 0.6 torr) also significantly increased Pao (7.8 +/- 1.2 torr), Pla (1.7 +/- 0.4 torr), and Qin (15.2 +/- 4.5%), while Qaa (-9.5 +/- 2.0%) and Qda (-26.3 +/- 7.0%) significantly decreased. Opposite findings were obtained immediately after release of abdominal compression. Thus, an acute increase in Pab with a constant pulmonary artery inflow increased the afterload imposed on the left ventricle and redistributed LV output, with a reduction in flow to the abdomen. Part of the fall in Qaa and increase in Pla could be attributed to passive elevation of the diaphragm by the increase in Pab, i.e., heart-lung-diaphragm interdependence.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000005:Abdomen / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001013:Aorta, Thoracic / Q000503:physiopathology; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002302:Cardiac Output; D003326:Coronary Circulation; D004285:Dogs; D004562:Electrocardiography; D011312:Pressure; D011651:Pulmonary Artery / Q000503:physiopathology; D012039:Regional Blood Flow; D012769:Shock / Q000503:physiopathology*; D014655:Vascular Resistance