Ichthyosis follicularis with alopecia and photophobia.
We treated two unrelated boys with ichthyosis follicularis, a rare skin disorder characterized by extensive noninflammatory spiny follicular hyperkeratoses, severe photophobia, and generalized noncicatricial alopecia. This disorder must be differentiated from keratosis follicularis spinulosa decalvans; ulerythema ophryogenes; keratosis pilaris rubra atrophicans faciei; atrichia with papular lesions; atrophodermia vermiculata; and keratitis, ichthyosis, and deafness syndrome, all of which share some clinical features. Ichthyosis follicularis with alopecia and photophobia appears to be a familial disorder, but too few cases have been reported to establish the exact mode of inheritance.
D000505:Alopecia / Q000150:complications* / Q000235:genetics / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007057:Ichthyosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D007642:Keratosis / Q000150:complications / Q000235:genetics / Q000473:pathology; D008027:Light; D008297:Male; D010375:Pedigree; D012867:Skin / Q000473:pathology