Blood platelet uptake of serotonin in men alcoholics.
Blood platelet uptake of 3H-serotonin (5HT uptake) was determined in a group of inpatient alcoholics who had just undergone detoxication (N = 19) and an age-matched group of nonalcoholic controls (N = 19). Mean 5HT uptake was 18% lower in the alcoholics (p less than .01). A 3-min 5HT uptake of less than 6 pmoles/10(7) platelets identified 58% of the alcoholics, but only 15% of the controls had a 5HT uptake lower than this value. These results support the hypothesis that serotonergic dysfunction may exist in alcoholics.
D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000097:blood; D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin