Effects on the caudate spindle in rats of taurine and gamma-aminobutyric acid (GABA) microinjected into the substantia nigra: involvement of the dopaminergic system.
Spindle bursts (caudate spindle) were recorded from the frontal cortex in rats. The bilateral intranigral microinjection of taurine suppressed the caudate spindle, whereas the same dose of gamma-aminobutyric acid (GABA) did not suppress the caudate spindle. These results indicate that suppression of the caudate spindle induced by taurine may relate to activation of the nigrostriatal dopaminergic neurons.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects*; D013654:Taurine / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D013654:Taurine; D005680:gamma-Aminobutyric Acid; D004298:Dopamine