[Effect of bromocryptin on the alcohol consumption and catecholamine level in the brain of rats undergoing long-term alcoholization].
It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals. Reduction in alcoholic motivation correlates with normalization of the level of dopamine, decreased by chronic alcohol action in the rat hypothalamus and midbrain. The use of bromocryptin also prevents an increase in the dopamine content in the rat hypothalamus during alcohol withdrawal.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001971:Bromocriptine / Q000627:therapeutic use*; D004298:Dopamine / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000378:metabolism; D013997:Time Factors
D001971:Bromocriptine; D004298:Dopamine; D009638:Norepinephrine
Vliianie bromokriptina na potreblenie alkogoloa i uroven' katekholaminov v mozge krys v usloviiakh dlitel'noĭ alkogolizatsii.