Penetration of aztreonam into human bronchial secretions.
Nine intubated patients were given a single, 2-g intravenous dose of aztreonam over 5 min. Samples of serum and bronchial secretion were obtained 2, 4, and 8 h after administration and assayed for aztreonam content. The mean concentrations in bronchial secretion ranged from 1.9 to 5.2 micrograms/ml and tended to be highest at 4 h. The concentrations in bronchial secretion varied from patient to patient, but each patient had one or more bronchial secretion samples that contained at least 2.7 micrograms of drug per ml.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001398:Aztreonam; D001980:Bronchi / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D013183:Sputum / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001398:Aztreonam