Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity.
Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to diminish mucositis resulting from 5-fluorouracil administration, whilst not affecting its systemic anti-tumour activity, an allopurinol mouthwash has been used. In six patients who experienced mucositis when treated initially with 5-fluorouracil, the use of an allopurinol mouthwash with subsequent courses resulted in a reduction of oral toxicity.
D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D009061:Mouth Mucosa / Q000187:drug effects; D009067:Mouthwashes; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013280:Stomatitis / Q000517:prevention & control*
D009067:Mouthwashes; D000493:Allopurinol; D005472:Fluorouracil