Myelopoiesis and marrow adherent cells in estradiol-treated mice.
Myelopoiesis and marrow adherent cells were evaluated in C57Bl/6J mice at two and four weeks after treatment with 0.1 mg 17 beta-estradiol cyclopentylpropionate. Estradiol-treated mice were lymphopenic and eosinopenic at two and four weeks; in addition, neutropenia occurred at four weeks. Numbers of lymphoid, granulocytic, and erythroid cells were decreased in the marrow at two and four weeks. The numbers of granulocyte-macrophage and fibroblast colony-forming units in the humeral marrow were also decreased at two and four weeks. However, the hematopoietic ability of marrow adherent cells was unchanged in estradiol-treated mice. Thymic cortical atrophy, metaphyseal osteosclerosis, and neutrophilic infiltration of the uterus occurred in estradiol-treated mice.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002448:Cell Adhesion; D003114:Colony-Forming Units Assay; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced; D008231:Lymphopenia / Q000139:chemically induced; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D014599:Uterus / Q000473:pathology
D004958:Estradiol; C007630:estradiol 17 beta-cypionate