N tau-methylhistidine: inhibitor of hepatic protein synthesis?
Protein synthesis in isolated perfused rat livers has been studied. Aminoacids at physiological rat concentration (U-14C)-Leucine 0.065 muCi/ml and N Tau-Methylhistidine His (Tau-Me) were added to the perfusion medium. His (Tau-Me) from 0.01 to 2.0 mM causes a reduction between 40-60% in the rate of secreted proteins, independently of the His (Tau-Me) concentration.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006639:Histidine / Q000031:analogs & derivatives*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D010477:Perfusion; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D008762:Methylhistidines; D006639:Histidine; D007930:Leucine; C028118:3-methylhistidine