[Systemic chemotherapy with super-high dose cisplatin and sodium thiosulfate (STS) rescue in mice].
We have devised a new systemic chemotherapy using cisplatin (DDP) with sodium thiosulfate (STS) rescue; basically, STS was given repeatedly 6 hours after DDP administration combined with metoclopramide. The effect of STS-rescue on the antitumor activity of DDP was studied using a BALB/c syngeneic fibrosarcoma (KKN-1). A graded dose of DDP was given i.p. with or without STS-rescue and its effects were evaluated according to N. C. I. protocol. A DDP dose-related antitumor activity was observed and the minimal effective doses were calculated as 8.2 and 9.8 mg/kg for groups treated with DDP alone and with STS-rescue, respectively. When STS-rescue was combined, however, super-high doses of DDP (9-16.5mg/kg) could be administered and this resulted in a 52% increase in chemotherapy index.
D000818:Animals; D001835:Body Weight; D002945:Cisplatin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013885:Thiosulfates / Q000008:administration & dosage*
D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin