[Dissolution processes and surface alteration. 4. Determination of the "effective" surface].
A method is described for measuring the "effective" surface of a drug by means of dissolution parameters using the Paddle-model or a resorption-model respectively. The obtained values were compared with the specific surface which was determined by BET-technique. The "effective" surfaces obtained by means of the dissolution parameters are smaller than those determined BET-technique.
D004058:Diffusion; D007700:Kinetics; D008956:Models, Chemical; D010634:Phenobarbital / Q000032:analysis; D010672:Phenytoin / Q000032:analysis; D012459:Salicylates / Q000032:analysis; D020156:Salicylic Acid; D012995:Solubility; D013499:Surface Properties
D012459:Salicylates; D010672:Phenytoin; D020156:Salicylic Acid; D010634:Phenobarbital
Auflösungsprozesse und Oberflächenänderung. 4. Mitteilung: Bestimmung der "effektiven" Oberfläche.