[Comparative evaluation of various methods of immunosuppressive therapy in severe bronchial asthma].
Altogether 216 patients with grave infection-dependent (49.5%) and autoimmune (50.5%) bronchial asthma received 311 courses of immunosuppressant therapy, with follow up periods up to 8 years. According to the clinico-immunologic data the patients were distributed into 4 groups. The basic drugs were (1) azathioprin, (2) azathioprin and prednisolone, (3) prednisolone, (4) delagil combined with heparin and epsilon-aminocaproic acid. Evaluation of the sort-term results of the treatment showed that the highest percentage of a clinical remission was attained with basic therapy including azathioprin combined with delagil and heparin. The immunosuppressants produced side effects in 14.2-31.3% of patients. These effects (dyspepsia, cytopenia, allergy) were of transitory nature. The long-term results were worse as compared with the short-term ones. The lethality for the whole group of patients amounted to 10.1%. It was caused by the status asthmaticus and cardiopulmonary insufficiency. Indications and contraindications for use of immunosuppressant therapy are provided.
D000293:Adolescent; D000328:Adult; D000368:Aged; D015119:Aminocaproic Acid / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D001327:Autoimmune Diseases / Q000188:drug therapy*; D001379:Azathioprine / Q000627:therapeutic use; D002738:Chloroquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D013224:Status Asthmaticus / Q000188:drug therapy
D007166:Immunosuppressive Agents; C023676:chloroquine diphosphate; D002738:Chloroquine; D006493:Heparin; D011239:Prednisolone; D001379:Azathioprine; D015119:Aminocaproic Acid
Sravnitel'naia otsenka razlichnykh metodov immunodepressivnoĭ terapii pri tiazhelom techenii bronkhial'noĭ astmy.