Water-soluble urokinase derivatives of combined action.
Modification of urokinase by substances possessing useful therapeutic activity permits combined action preparations to be obtained. The catalytic properties of the modified enzyme are close to those of native urokinase. The attachment of sodium nitroprusside to it provides vasodilator action with a prolonged effect. Modification of urokinase by heparin produces stabilized preparations possessing fibrinolytic and anticoagulation activity simultaneously. The possibility of repeatedly modified urokinase obtaining has been demonstrated experimentally. Urokinase-heparin-sodium nitroprusside conjugates have fibrinolytic, hypotensive and anticoagulant effect simultaneously. The approaches suggested indicate possible new ways of creating effective therapeutics.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D007275:Injections, Intravenous; D009599:Nitroprusside / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology* / Q000627:therapeutic use; D014867:Water
D000925:Anticoagulants; D014867:Water; D009599:Nitroprusside; D000244:Adenosine Diphosphate; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator