The affected sib method. I. Statistical features of the affected sib-pair method.
The distribution of the number of HLA haplotypes shared by sibs affected with the same HLA-linked disease can be used to obtain information on the genetics of the disease. Since the inception of the use of sib-pair methods for the analysis of the HLA-associated diseases, the question has been raised of how to include families with more than two affected sibs in the sib-pair analysis. This paper presents appropriate weighting schemes. A procedure for estimating the frequency of the disease allele in the general population, under the assumptions of single-allele recessive, additive, dominant and intermediate models, with negligible recombination (theta = 0) between the disease-predisposing gene and the HLA region, and no selective disadvantage of the trait, is also given. Cluster-sampling techniques are used in the analysis.
D000483:Alleles; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D005190:Family; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D010375:Pedigree
D006680:HLA Antigens