Isolation and characterization of hemagglutinins from the sponge Dysidea herbacea.
The sponge Dysidea herbacea (Keller) was found to possess hemagglutinins. The major component, DHA-I, is a protein with a mol. wt of 26,000, which dissociates into subunits of equal size (14,000). It contains large amounts of glutamic acid and aspartic acid residues, but no half-cystine, methionine or histidine residues. DHA-I reacted with rabbit and human AB0 erythrocytes. D-galactose and lactose were effective inhibitors of DHA-I. The sponge also contained a minor component(s) which reacted preferentially with rabbit erythrocytes but not with human AB0 erythrocytes.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D006385:Hemagglutination Inhibition Tests; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011161:Porifera; D011817:Rabbits
D000596:Amino Acids; D006388:Hemagglutinins; D046911:Macromolecular Substances