The immune response to pertussis in the 6-day air pouch: a model of chronic synovitis.
We have developed a model of prolonged immunological inflammation in the rat which has a structural resemblance to the synovial changes in rheumatoid arthritis. Pertussis vaccine was injected into 6-day-old subcutaneous air pouches in animals previously sensitized with pertussis vaccine. The resulting inflammatory response persisted up to 30 days. Examination of exudates showed a wave of polymorphonuclear leucocytes over a 13-day period followed by a mononuclear cell predominance up to 30 days. Histologically, an early polymorphonuclear cell infiltration was followed by the formation of a lining layer of large eosinophilic mononuclear cells, together with deep collections of lymphocytes and plasma cells. Concentrations of the acute-phase reactant alpha 1-glycoprotein, in both serum and exudate, peaked at 3 days. This suggests that the local production of interleukin I in this type of tissue reaction is more closely related to the acute inflammatory phase than to more chronic interactions between monocyte derived cells and lymphocytes.
D000388:Air; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000166:cytology / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D007279:Injections, Subcutaneous; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D009504:Neutrophils; D010567:Pertussis Vaccine / Q000276:immunology*; D051381:Rats; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
D006023:Glycoproteins; D010567:Pertussis Vaccine