DNA synthesis inhibitory peptides in mammalian serum and insect hemolymph.
Similar inhibitory factors for DNA synthesis were found in fetal calf serum and a hemolymph of the moth, Bombyx mori. The factors were highly purified by gel filtration, ion exchange and thin layer chromatography and appeared to be heat-stable. They showed the same effects on some bacteria and mammalian cells. The significance of these DNA synthesis inhibitory 1 Kd peptides is discussed.
D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D012831:Bombyx / Q000378:metabolism*; D002417:Cattle; D004247:DNA / Q000096:biosynthesis*; D006458:Hemolymph / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000097:blood* / Q000494:pharmacology
D010455:Peptides; D004247:DNA