The effects of Ba-wei-wan (hachimijiogan) on plasma levels of high density lipoprotein-cholesterol and lipoperoxide in aged individuals.
Ba-wei-wan was administered for 7 months to 24 aged, non-hospitalized subjects. Laboratory examinations showed an improvement in serum or plasma levels of total lipid, LPO and HDL-C. Other blood examinations were shown to be unaffected by the treatment. To reconfirm the effects of Ba-wei-wan on lipid metabolism, the three step administration of the drug was employed. The elevation of HDL-C levels and the decrease of LPO levels were obtained by this treatment. The discontinuation of this drug induced the converse effect on the plasma levels; decreased HDL-C and increased LPO. It could be concluded from these results that Ba-wei-wan administration improved the lipid metabolism in the aged subjects.
D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents; D007564:Japan; D008054:Lipid Peroxides / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D010946:Plants, Medicinal
D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D008054:Lipid Peroxides; D008055:Lipids