Microbial hydroxylation of compactin (ML-236B) and monacolin K.
The Basidiomycete Schizophyllum commune was found to transform compactin (ML-236B) to 8a-hydroxycompactin. This compound was isolated by solvent extraction and column chromatography, and its structure was determined by a combination of IR, UV, 1H NMR and 13C NMR spectroscopy. Monacolin K was also converted to the corresponding hydroxylated analogue. Data on the inhibition of 3-hydroxy-3-methylglutaryl co-enzyme A reductase and sterol biosynthesis in vitro are presented for these hydroxylated compounds.
D000363:Agaricales / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D000924:Anticholesteremic Agents / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D006900:Hydroxylation; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008148:Lovastatin / Q000031:analogs & derivatives; D009281:Naphthalenes / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D012567:Schizophyllum / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009281:Naphthalenes; C012258:mevastatin; D008148:Lovastatin