Late-onset erythropoietic protoporphyria with unusual cutaneous features.
A 68-year-old man with apparently light-exacerbated erythematous cutaneous plaques on his face and on the dorsa of his hands was found to have late-onset erythropoietic protoporphyria, diabetes mellitus, and hyperlipidemia. Extensive deposits of material that stained with periodic acid-Schiff were present in the lesional dermis. Monospecific antibody studies showed this material to be mainly type IV collagen. These findings strongly suggest that the lesions are a manifestation of erythropoietic protoporphyria. The late onset and asymptomatic unusual cutaneous lesions appear to be a new presentation of the disease.
D000368:Aged; D003094:Collagen / Q000032:analysis; D005243:Feces / Q000032:analysis; D006225:Hand; D006801:Humans; D008297:Male; D011164:Porphyrias / Q000473:pathology*; D011524:Protoporphyrins / Q000032:analysis / Q000097:blood; D012867:Skin / Q000032:analysis / Q000473:pathology*
D011524:Protoporphyrins; D003094:Collagen