[The anti-inflammatory effect of a combination of dimethindene maleate and betamethasone in topical formulations].
The antiinflammatory activity of three preparations (cream, ointment, jelly) of Fenistil Plus (betamethasone + dimethindene maleate) was shown by means of reflection densitometry, a new pharmacodynamic model. The three preparations led to restitution of the Tesafilm-stripped skin within 4 h. There was no significant difference in the efficacy of the preparations. After application of 10 g of the ointment the plasma levels of betamethasone remained within the limits of identification of the analytical method. An influence of the drug on the endogenous plasma hydrocortisone (cortisol) levels could not be found.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001623:Betamethasone / Q000097:blood; D004115:Dimethindene / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D011863:Radioimmunoassay; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D004115:Dimethindene; D001623:Betamethasone; D006854:Hydrocortisone
Zur antiinflammatorischen Wirksamkeit einer Kombination aus Dimetindenmaleat und Betamethason in topischen Darreichungsformen.