title: Hyperlipidemia and noise in the chinchilla.
abstract: Chinchillas were maintained on a 1% cholesterol diet for 6 months. Auditory Brainstem Response (ABR) measurements were obtained before and at 1, 3, 5, and 6 months after initiation of diet. Compound Action Potential (AP) measurements were obtained at sacrifice at 6 months. A significant reduction in ABR was seen at 5 months-on-diet. At 5 months, the animals were exposed to a 2 octave bandpass noise centered at 1 kHz at 105 dB for 220 min. One month following noise exposure, the cholesterol-fed animals exhibited a greater ABR latency shift at low intensities, and an elevated AP threshold at higher frequencies, vis-à-vis a control group.
mesh_terms: D000818:Animals; D002682:Chinchilla; D003051:Cochlea / Q000503:physiopathology*; D004036:Diet, Atherogenic; D004781:Environmental Exposure; D005072:Evoked Potentials, Auditory; D006949:Hyperlipidemias / Q000209:etiology / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D009622:Noise; D011930:Reaction Time
chemical_list: D008055:Lipids