Testosterone and dihydrotestosterone levels in epididymis, vas deferens, seminal vesicle and preputial gland of mice after hCG injection.
Temporal changes of testosterone (T) and dihydrotestosterone (DHT) levels were measured by RIA in epididymis, vas deferens, seminal vesicle and preputial gland of adult male mice after a single injection of hCG. The response of circulating T to hCG stimulation was rapid and persisted over a period of 48 h. The temporal changes of androgen content of target organs paralleled the modifications of circulating T. In all organs the high androgen levels attained at 1 or 4 h plateaued until 24 h, decreased thereafter and returned to basal values at 72 h. The concentration of T by sex accessory organs was more accelerated by hCG injection than its conversion into DHT.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000378:metabolism*; D004822:Epididymis / Q000378:metabolism*; D005837:Genitalia, Male / Q000187:drug effects; D007700:Kinetics; D008297:Male; D010413:Penis / Q000378:metabolism*; D051381:Rats; D012627:Sebaceous Glands / Q000378:metabolism*; D012669:Seminal Vesicles / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*; D013997:Time Factors; D014649:Vas Deferens / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone; D013739:Testosterone