title: Development of kindling: whole-brain stimulation in rats.
abstract: Previous studies have demonstrated that low-intensity electrical stimulation of some specific brain regions in several animal species leads to gradual changes in behavior, culminating in generalized seizures (kindling). We found that repeated whole-brain stimulation in rats with electrical currents of 5 and 3 mA elicited progressive behavioral changes and finally triggered convulsive seizures.
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains