Pharmacokinetics and absolute bioavailability of intramuscular tranexamic acid in man.
The bioavailability of tranexamic acid after the administration of a single intramuscular dose was estimated in three healthy male volunteers. 500 mg tranexamic acid were given intramuscularly and intravenously, as a bolus injection, to each subject on separate occasions. Following intramuscular administration, the peak plasma concentrations were attained after approximately one hour and the apparent elimination half-life was about two hours. The absolute bioavailability was 105.2 +/- 10.7% (mean +/- SD). At the dose given, the bioavailability of tranexamic acid after intramuscular administration is fast and complete.
D000328:Adult; D001682:Biological Availability; D003509:Cyclohexanecarboxylic Acids / Q000378:metabolism*; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D014148:Tranexamic Acid / Q000008:administration & dosage / Q000378:metabolism*
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid