Cholinergic modulation of mediodorsal thalamic input into cingulate cortex.
Field potentials in cingulate cortex (area 24) produced by electrical stimulation of the mediodorsal thalamic nucleus were diminished by iontophoretic ejection of the cholinergic agonist, carbachol. The effect was frequency dependent: field potentials produced by 7.0 Hz stimulation were reduced by 34%. Potentials produced by 0.5 Hz stimulation were not significantly changed. This reduction was blocked by muscarinic but not nicotinic antagonists.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology; D011978:Receptors, Nicotinic / Q000502:physiology; D013787:Thalamic Nuclei / Q000502:physiology*
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D002217:Carbachol