Propoxyphene and acetaminophen mixture (Darvocet)--related radiation-induced pneumonitis.
In a patient undergoing radiation therapy for recurrent, metastatic breast cancer, a mixture of propoxyphene and acetaminophen (Darvocet) was given for intercurrent viral infection. Discontinuation of therapy with this medication coincided with appearance of pneumonitis, reminiscent of the steroid withdrawal--related radiation pneumonitis.
D000082:Acetaminophen / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000532:radiotherapy; D011431:Dextropropoxyphene / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors; D014777:Virus Diseases / Q000188:drug therapy
D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D011431:Dextropropoxyphene