Gastric carcinoids of ECL cells. Pathological and clinical analysis of eight cases.
Clinical, histological, histochemical and ultrastructural characteristics of eight cases of carcinoid tumors of the non-antral portion of the stomach are presented. Four cases with multiple polypoid lesions are accompanied by an increased level of gastrin. A normal level of gastrin was present in the other four cases with isolated tumor and a normal component of endocrine cells in the uninvolved mucosa. In the first group with multiple lesions, the histological and histochemical analysis of the endocrine cells revealed a wide range of appearances: a) "simple hyperplasia", b) "nodular hyperplasia", and c) carcinoid tumor. These aspects suggested a different pathogenesis for the carcinoid tumors of the non-antral portion of the stomach with possible therapeutical implications.
D000126:Achlorhydria / Q000378:metabolism; D000328:Adult; D000368:Aged; D002273:Carcinogens / Q000378:metabolism; D002276:Carcinoid Tumor / Q000097:blood / Q000145:classification / Q000473:pathology*; D002838:Chromaffin System / Q000648:ultrastructure*; D004759:Enterochromaffin Cells / Q000648:ultrastructure*; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology; D013270:Stomach / Q000648:ultrastructure; D013274:Stomach Neoplasms / Q000097:blood / Q000145:classification / Q000473:pathology*
D002273:Carcinogens; D005755:Gastrins