High-dose intravenous metoclopramide and intermittent intramuscular prochlorperazine and diazepam in the management of emesis induced by cis-dichlorodiammineplatinum.
Intravenous metoclopramide and IM prochlorperazine and diazepam were compared in the management of vomiting occurring during treatment with cis-dichlorodiammineplatinum (cis-platinum). A total of 104 cycles in 30 patients were evaluated. Twenty-two patients took part in a cross-over study in which emetic profiles for each patient managed with each anti-emetic schedule were compared. In all, 44 cycles of treatment in 22 patients were evaluated as part of a cross-over study. No significant difference in emetic control was observed between the two anti-emetic regimens. The side-effects observed using IV metoclopramide included extrapyramidal phenomena (19%) and flushing attacks (16%).
D000932:Antiemetics / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects*; D003975:Diazepam / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006801:Humans; D007273:Injections, Intramuscular; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D011346:Prochlorperazine / Q000008:administration & dosage*; D014839:Vomiting / Q000517:prevention & control*
D000932:Antiemetics; D008787:Metoclopramide; D002945:Cisplatin; D003975:Diazepam; D011346:Prochlorperazine