Cryoglobulinemia and immune-mediated glomerulonephritis in association with hairy cell leukemia.
The nephrotic syndrome in association with hairy cell leukemia is typically seen in the setting of amyloidosis. This report describes a patient with the nephrotic syndrome and hairy cell leukemia in whom cryoglobulinemia and an immune-mediated glomerulonephritis were seen. While hairy cells have the capacity for immunoglobulin production, we were unable to demonstrate a teleological link between these cells and the renal lesion. In contrast, there is speculative evidence to suggest that indolent infections may have played a causative role in cryoglobulin production and the subsequent immune-mediated glomerulonephritis.
D003449:Cryoglobulinemia / Q000150:complications*; D004754:Enterobacter; D004756:Enterobacteriaceae Infections / Q000150:complications; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007672:Kidney Cortex / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology; D007943:Leukemia, Hairy Cell / Q000150:complications*; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000473:pathology; D011507:Proteinuria / Q000150:complications; D018805:Sepsis / Q000150:complications
D007136:Immunoglobulins