Metabolism of benzydamine.
After an oral dose of 50 mg benzydamine to three volunteers, urinary metabolites were identified by mass spectrometric techniques. 50-65% of the dose was excreted unchanged with the urine. The main metabolic pathways were elimination of the dimethylaminopropyl group, elimination of the benzyl group, desmethylation, N-oxidation, and hydroxylation of the benzene ring. Didesmethylbenzydamine and hydroxybenzydamine were excreted in form of their corresponding glucuronides.
D001591:Benzydamine / Q000378:metabolism*; D001711:Biotransformation; D003640:Dealkylation; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D010084:Oxidation-Reduction; D011720:Pyrazoles / Q000378:metabolism*
D011720:Pyrazoles; D001591:Benzydamine