[Enhanced resistance of the myocardium to stress injury and excess calcium in spontaneously hypertensive rats].
Extensibility, contractile function and resistance to excess calcium of the right atrium myocardium were studied in normotensive Wistar-Kyoto and August rats and in spontaneously hypertensive rats (SHR). It was shown that long-term stress results in a decrease in the measured parameters in normotensive animals. SHR do not show any stress-induced disturbances. It was discovered that in intact SHR rats, the myocardium has a greater resistance to excess calcium, indirect evidence for higher efficiency of the Ca-pump of the sarcoplasmic reticulum in cardiomyocytes of SHR animals, which is apparently a constituent part of the mechanism of such animals' heart increased resistance to stress-induced damage.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000008:administration & dosage* / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology*; D011921:Rats, Inbred WKY; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*
D002118:Calcium
Povyshennaia rezistentnost' miokarda krys so spontannoĭ nasledstvennoĭ gipertonieĭ k stressornomu povrezhdeniiu i izbytku kal'tsiia.