title: Bombesin, gastrin releasing peptide and vasoactive intestinal peptide excite myenteric neurons.
abstract: Intracellular recording methods were used to study the actions of bombesin, gastrin releasing peptide and vasoactive intestinal peptide on electrical behavior of AH/Type 2 myenteric neurons in guinea-pig ileum in vitro. Each peptide evoked membrane depolarization associated with increased input resistance, enhanced excitability and suppression of hyperpolarizing after-potentials. The effects of the peptides simulated slow synaptic excitation in the myenteric plexus and are consistent with a neurotransmitter or neuromodulatory function.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D004594:Electrophysiology; D019886:Gastrin-Releasing Peptide; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008845:Microinjections; D009197:Myenteric Plexus / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology*; D013779:Tetrodotoxin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
chemical_list: D010455:Peptides; D014660:Vasoactive Intestinal Peptide; D013779:Tetrodotoxin; D019886:Gastrin-Releasing Peptide; D001839:Bombesin