Can neonatal beta-adrenergic stimulation prevent the effects of androgenization in female rats?
A 25 micrograms dose of testosterone propionate injected at 4 days of age induced 90% anovulation at 100 days of age. The systemic administration of orciprenaline (8 or 16 micrograms) or yohimbine (100 micrograms) did not prevent androgenization. Twenty-five or fifty micrograms of orciprenaline injected intraventricularly reduced only partially (to 54 and 67% respectively) the effectiveness of androgenization. We concluded that beta-adrenergic receptor stimulation had a very limited ability to prevent androgenization, since the beta-stimulation obtained directly with orciprenaline prevented androgenization to a very limited extent, while the possible indirect stimulation through an increase in norepinephrine endogenous release by alpha-2 receptor blocker yohimbine was ineffective.
D000818:Animals; D000831:Animals, Newborn; D004971:Estrus / Q000187:drug effects; D005260:Female; D009921:Metaproterenol / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects*; D013739:Testosterone / Q000037:antagonists & inhibitors*; D014621:Vagina / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology*
D015016:Yohimbine; D013739:Testosterone; D009921:Metaproterenol