Corneal penetration and metabolism of the antiherpetic 5-iodo-2'-deoxycytidine.
The study of the permeability of the cornea to 5-iodo-2'-deoxycytidine (IDC), an antiherpetic agent was performed in the rabbit. In a first experiment, using 125I-IDC eye-drops and a sustained contact between the drug and the cornea, we showed that the penetration of IDC in the aqueous humor was important. In a second experiment, using a HPLC method, we studied comparative ocular penetration and metabolism of IDC and 5-iodo-2'-deoxyuridine (IDU).
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D001972:Bromodeoxycytidine / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid; D003315:Cornea / Q000378:metabolism*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000378:metabolism; D006564:Herpesviridae / Q000187:drug effects; D007065:Idoxuridine / Q000378:metabolism; D008297:Male; D009883:Ophthalmic Solutions; D010539:Permeability; D011817:Rabbits; D011868:Radioisotopes
D000998:Antiviral Agents; D009883:Ophthalmic Solutions; D011868:Radioisotopes; D003841:Deoxycytidine; D001972:Bromodeoxycytidine; C011288:ibacitabine; D007065:Idoxuridine