Chylomicronemia induced by cimetidine.
A 35-yr-old man with moderate hypertriglyceridemia, associated with a positive family history for hyperlipidemia, developed chylomicronemia with abdominal pain, muscle pain, and splenomegaly while being treated with cimetidine for a duodenal ulcer. The chylomicronemia and the pain subsided after the drug was stopped. When the patient was rechallenged with the drug 6 mo later, the chylomicronemia reappeared after a treatment period of 6 days. Chylomicronemia and its complications should therefore be considered as a potential risk when cimetidine is prescribed to patients with known hyperlipidemia.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000097:blood*; D002927:Cimetidine / Q000009:adverse effects*; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000150:complications / Q000235:genetics; D008297:Male; D010375:Pedigree; D013577:Syndrome; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D014280:Triglycerides; D002927:Cimetidine; D002784:Cholesterol