Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation?
The ether-linked phospholipid, Paf-acether (AGEPC) is released from a variety of inflammatory cell types and has properties consistent with those of a mediator of inflammation. We have examined the effects of locally administered Paf-acether on cellular accumulation in the skin of experimental animals and man by histological evaluation of sequential skin biopsies and quantification of accumulation of radiolabelled blood elements. In guinea-pig skin, immediate extravasation of plasma protein and intravascular accumulation of platelets and neutrophils was succeeded by a persistent mixed cellular infiltrate predominantly of neutrophils but also containing lymphocytes and histiocytes. Radiolabelling studies were consistent with these observations. Intradermal Paf-acether elicited persistent clinical and histopathological responses in human skin. The finding that Paf-acether is able to initiate cutaneous cellular accumulation may be important in the pathogenesis of inflammatory dermatoses.
D000208:Acute Disease; D000818:Animals; D002465:Cell Movement; D002908:Chronic Disease; D003872:Dermatitis / Q000378:metabolism / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D010972:Platelet Activating Factor / Q000494:pharmacology / Q000502:physiology*; D012867:Skin / Q000187:drug effects / Q000473:pathology*
D010972:Platelet Activating Factor