Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium.
The induction of myocardial infarction in rats by ligation of the left-anterior coronary artery was confirmed by measurement of increased plasma levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase. Using this model system it has been established that intravenous administration of 125I-labelled hyaluronidase to rats resulted in a preferential uptake of the enzyme by damaged myocardium as compared to normal heart tissue.
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
D003402:Creatine Kinase; D006821:Hyaluronoglucosaminidase