Narcotic antagonist potentiation of apomorphine drug effect: a stereospecific, centrally mediated drug action.
Systemic pretreatment with naloxone but not its (+)-enantiomer significantly potentiated apomorphine-induced stereotypic climbing activity in mice. Systemic or central pretreatment with naltrexone also significantly potentiated the apomorphine drug effect. The N-methyl derivative of naltrexone had no influence when administered systemically but significantly potentiated the apomorphine drug effect when administered centrally. These findings suggest that narcotic antagonist potentiation of apomorphine-induced stereotypic climbing in mice is a stereospecific phenomenon that originates in the central nervous system.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects
D009292:Narcotic Antagonists; D009270:Naloxone; D009271:Naltrexone; D001058:Apomorphine