[Studies on antibiotics distribution in the post-operative cavity].
In 17 post-operative patients, serum and operation cavity exudate levels after 2 g administration of various cephems (CZX, LMOX, CTX, and CPZ) by one hour drip infusion were evaluated. Drug concentration in exudate (actual levels) was corrected by using an equation for the purpose of excluding blood contamination. After 2 hours from the start of infusion, theoretical levels generally were similar to actual levels. CZX: Peak exudate level was 38.9 micrograms/ml at 4 hours. Maximum exudate level/maximum serum level (E/S) was 0.31. LMOX: Peak in exudate was 41.4 micrograms/ml at 4 hours. E/S was 0.59. CTX: Exudate peak level was 30.8 micrograms/ml at 2 hours, and E/S was 0.53. CPZ: Peak level in exudate was 74.0 micrograms/ml at 4 hours. E/S was 0.36. Generally, peaks occurred at 4 hours (3 hours later than serum peaks), and their range was between 30 and 80 micrograms/ml. At 8 hours, drug levels in exudate were 10 approximately 60 micrograms/ml, and they were higher than the corresponding serum level at that time.
D000328:Adult; D000368:Aged; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013530:Surgical Wound Infection / Q000517:prevention & control; D014551:Urinary Tract / Q000601:surgery*; D014570:Urologic Diseases / Q000378:metabolism / Q000601:surgery
D002511:Cephalosporins