[Utilization of the pharmacokinetic parameters of acetylsalicylic acid for optimizing its use with people of different ages].
Nomograms for application of acetylsalicylic acid in persons of different age are presented. The nomograms are based on pharmacokinetic parameters of acetylsalicylic acid with regard to the age. Proceeding from the known constants of absorption and elimination, the nomograms are made use of to screen the loading and maintenance doses, to determine the time of administering the first maintenance dose and the maximal amount of the drug in the body, which was built up as a result of the use of the accepted treatment schedule. While using the nomograms one should be guided by the known therapeutic dose and the dosage intervals or by the therapeutic or maximal allowable dose. The nomograms are unsophisticated, fairly convenient, and help determine the optimal regimen of the use of acetylsalicylic acid in persons of different age.
D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects*; D001241:Aspirin / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D013997:Time Factors
D001241:Aspirin
Ispol'zovanie farmakokineticheskikh parametrov atsetilsalitsilovoĭ kisloty dlia optimizatsii ee primeneniia u liudeĭ raznogo vozrasta.