A description of human placental syncytiotrophoblast membrane glycosphingolipids.
The glycosphingolipid (GSL) structure of isolated human term placental syncytiotrophoblast microvillous plasma membrane (StMPM) has been investigated by Folch solvent extraction and thin-layer chromatography. StMPM preparations were shown to contain unique hydrophilic GSL species, including two highly glycosylated (greater than 15 saccharide residues/molecule) components. This fraction consistently included four major gangliosides (sialylated GSL), as well as two highly-sialylated (greater than or equal to 4 sialic acid residues/molecule) minor gangliosides.
D002462:Cell Membrane / Q000032:analysis; D002855:Chromatography, Thin Layer; D005260:Female; D006028:Glycosphingolipids / Q000032:analysis*; D006801:Humans; D008871:Microvilli / Q000032:analysis; D010920:Placenta / Q000032:analysis / Q000648:ultrastructure*; D011247:Pregnancy; D014327:Trophoblasts / Q000032:analysis / Q000648:ultrastructure*
D006028:Glycosphingolipids