Cardiac effects of fenoterol hydrobromide on newborn versus adult rats.
The toxicity of fenoterol hydrobromide, a beta-adrenoceptor stimulant, was studied in newborn and adult SD-rats dosed with 0 (control), 2.5, 75 and 600 mg/kg/day by gavage for 35 days. 600 mg/kg was lethal for both age groups: newborn rats died either from gastro-intestinal disorders during the lactation period or from underweight and cachexia immediately after weaning. Adult rats which died from 600 mg/kg showed extended myocardial scars. No substance-related myocardial lesions were observed in newborn rats killed terminally, whereas adult rats had a dose-dependent increase in heart weights, at 600 mg/kg also extended myocardial scars.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004983:Ethanolamines / Q000633:toxicity*; D005260:Female; D005280:Fenoterol / Q000633:toxicity*; D006321:Heart / Q000033:anatomy & histology / Q000187:drug effects*; D008168:Lung / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012469:Salivary Glands / Q000187:drug effects
D004983:Ethanolamines; D005280:Fenoterol