Relationships between radiological and biochemical evidence of rickets in Asian schoolchildren.
One hundred Asian schoolchildren provided evidence of the relationships between radiological and biochemical evidence of rickets in a vitamin D-deficient population. In a retrospective study of the X-rays of 56 children the variables serum alkaline phosphatase, inorganic phosphorus and age provided a discriminant function which correctly classified 10 of 11 children with radiological evidence of rickets and 44 of 45 children with negative or marginally abnormal X-rays. When the discriminant function was applied to a prospective study of 44 children, three children with radiological evidence of rickets were correctly classified together with 38 of the remaining 41 children with negative or marginally abnormal X-rays. Serum alkaline phosphatase was the most important variable in the discriminant analysis, followed by serum inorganic phosphorus and age. Low levels of serum 25-hydroxy vitamin D (25-OHD) are of little value in predicting the severity of radiological evidence of rachitic bone disease in a vitamin D-deficient population.
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D002112:Calcifediol / Q000097:blood; D002648:Child; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D010758:Phosphorus / Q000097:blood; D011446:Prospective Studies; D011859:Radiography; D012189:Retrospective Studies; D012279:Rickets / Q000097:blood / Q000000981:diagnostic imaging* / Q000201:enzymology; D012709:Serum Albumin / Q000378:metabolism
D012709:Serum Albumin; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002112:Calcifediol