[Application of an original technic in the evaluation of gastric emptying to the study of primperan].
The ingestion of radio-opaque granules during a meal enables the radiological study of gastric emptying under physiological conditions. The evacuation of the granules is well correlated with that of solids. After the development of a pharmaco-clinical model of hyposthenic dyspepsia, this technique was used by the authors to evaluate the influence of Primperan on gastric emptying after a dyspeptogenic meal in 12 volunteers. Following the randomised intravenous injection of either 20 mg of Primperan or a placebo, 5 to 7 minutes before the dyspeptogenic meal, the number of granules remaining in the stomach over time was used to measure the rate of gastric emptying. Primperan significantly accelerated the gastric emptying of the dyspeptogenic meal in comparison with the placebo (p less than 0.01).
D003287:Contrast Media; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008787:Metoclopramide / Q000494:pharmacology*; D011859:Radiography; D013270:Stomach / Q000000981:diagnostic imaging*
D003287:Contrast Media; D008787:Metoclopramide
Application d'une technique originale d'évaluation de l'évacuation gastrique à l'étude du primpéran.