The role of microfilaments in the healing of the corneal endothelium.
Actin microfilaments are presumed to play a role in cell locomotion. The function of these filaments may be selectively suppressed by cytochalasin. A dose-dependent delay of the repair of a corneal endothelial defect by the application of cytochalasin in tissue culture has been observed by SEM. This observation confirms that the actin microfilaments are important for the endothelial repair.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003315:Cornea / Q000187:drug effects / Q000502:physiology*; D003470:Culture Media; D015638:Cytochalasin D; D003572:Cytochalasins / Q000494:pharmacology*; D003599:Cytoskeleton / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D003470:Culture Media; D003572:Cytochalasins; D015638:Cytochalasin D