[Structure of DNA from the rat thymus during prolonged exposure to tritium oxide and external gamma-irradiation].
Thymus depopulation, DNA destruction as estimated according to the level of single-stranded breaks (SSB) and DNA structural derangement revealed by the viscosimetric assay of alkaline lysed thymocytes were observed in the course of a prolonged (1 mos) radiation exposure to tritium oxide (the 1st group) and equidimensional external gamma-irradiation (the 2nd group) in a summary dose of 10 Gy in rats. Depletion and destruction were 1.5-2 times more pronounced in case of HTO exposure. A study of the repair has revealed an increase in the number of hardly repairable or irrepairable breaks by the end of the study: by the 25th day the number of SSB repaired after additional test irradiation was O and 30% in the rats of the 1st and 2nd groups respectively.
D000818:Animals; D004260:DNA Repair / Q000528:radiation effects*; D004277:DNA, Single-Stranded / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D009690:Nucleic Acid Conformation; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000378:metabolism* / Q000528:radiation effects; D013997:Time Factors; D014316:Tritium / Q000494:pharmacology*; D014867:Water / Q000494:pharmacology*
D004277:DNA, Single-Stranded; D014867:Water; D014316:Tritium; C033961:tritium oxide
Struktura DNK vilochkovoĭ zhelezy krys pri dlitel'nom vozdeĭstvii okisi tritiia i vneshnego gamma-oblucheniia.