Possible teratogenic effects of artificial insemination by donor.
Three trisomic offspring conceived by artificial insemination by donor (AID) were observed in a population in which a total of about 400 babies were so conceived. To test whether this excess represented a random fluctuation or a real effect of the AID procedure we surveyed, by questionnaire, a group of women who had born children conceived by AID. A significantly higher number of trisomic offspring were found than expected in a population with the observed age distribution. Further data are needed to test the validity of this observation.
D000022:Abortion, Spontaneous / Q000209:etiology; D000013:Congenital Abnormalities / Q000209:etiology*; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000009:adverse effects*; D011247:Pregnancy; D014314:Trisomy