Coronary arterial lesions in piglets from sows fed moderate excesses of vitamin D.
Ultrastructural studies were conducted on the coronary arteries of 6 week-old piglets from sows which received diets containing either 25 micrograms or 3.7 micrograms of vitamin D3 per pound of basal ration. The subendothelial space which was rich in mucopolysaccharide and newly formed tiny elastic fibers, contained numerous macrophages, some of which possessed lipid droplets. Degenerated smooth muscle cells with pyknotic nuclei or vesiculated organelles, and mitotic smooth muscle cells were occasionally seen in the coronary artery. Piglets from sows which were fed high doses of vitamin D had more degenerated smooth muscle cells without stainable lipid and lipid containing cells in their coronary arteries than piglets from sows which were fed low doses of vitamin D. These results suggested that an excess dietary intake of vitamin D by pregnant animals may have potential angiotoxic effects on the coronary arteries of their offsprings.
D000818:Animals; D000833:Animals, Suckling; D003327:Coronary Disease / Q000139:chemically induced / Q000151:congenital / Q000662:veterinary*; D003331:Coronary Vessels / Q000473:pathology; D004727:Endothelium / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008055:Lipids / Q000032:analysis; D008431:Maternal-Fetal Exchange; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D009751:Nutritional Requirements; D011247:Pregnancy; D011270:Pregnancy, Animal; D013045:Species Specificity; D013552:Swine / Q000502:physiology*; D013553:Swine Diseases / Q000139:chemically induced* / Q000151:congenital / Q000473:pathology; D014807:Vitamin D / Q000008:administration & dosage / Q000633:toxicity*
D008055:Lipids; D014807:Vitamin D