Some changes in gastro-intestinal metabolism and in the urine and bladders of rats in response to sodium saccharin ingestion.
In rats fed sodium saccharin in the diet changes in urine composition, increased bladder-tissue mass and, in males only, an accumulation of minerals in the bladder tissue have been observed. In this report evidence is presented that indicates that these changes are a consequence of the effects of sodium saccharin in the gastro-intestinal tract and are not due to systemic sodium saccharin. Sodium saccharin has been shown to inhibit gastro-intestinal enzymes that digest carbohydrates and proteins and to increase caecal absorption of mineral ions. The significance of these findings to saccharin-associated bladder tumorigenesis is discussed.
D000818:Animals; D002432:Cecum / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism; D004064:Digestive System / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000633:toxicity*; D012737:Sex Factors; D001743:Urinary Bladder / Q000187:drug effects*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced; D014556:Urine / Q000187:drug effects*
D004040:Dietary Carbohydrates; D004573:Electrolytes; D012439:Saccharin