Characteristic changes of plasma proteins in the Dahl hypertensive rat strain (DS) during the development of hypertension.
Several recent studies have reported the existence of additional plasma proteins in essential hypertensive patients and strains of genetically hypertensive rats. The aim of this work was to look for similar changes in a model of salt induced hypertension, the Dahl salt sensitive (DS) rat, using the sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis. No additional proteins were found when different staining techniques were employed (Coomassie, silver). However, during the development of hypertension a characteristic change in the plasma protein pattern of DS rats occurred, which could not be detected in the majority of normotensive control animals. Treatment with nifedipine inhibited both the development of hypertension and this specific change in the plasma proteins, in spite of continuous dietary salt loading. It is postulated that the plasma protein changes reflect a regulatory phenomenon of hypertension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006973:Hypertension / Q000097:blood*; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*
D001798:Blood Proteins; D012965:Sodium Chloride; D009543:Nifedipine