title: Effects of vitamins on lipid peroxidation and suppression of DNA synthesis induced by adriamycin in Ehrlich cells.
abstract: The effects of various vitamins on lipid peroxidation and the suppression of DNA synthesis induced by adriamycin (ADR) in vitro using Ehrlich ascites carcinoma (EAC) cells were studied. ADR produced a concentration-dependent stimulation of lipid peroxidation in EAC cells. alpha-Tocopherol and coenzyme Q10 inhibited ADR-induced lipid peroxidation to about the same extent and these effects were the greatest for all antioxidants added. The inhibitory effect of riboflavin 2',3',4',5'-tetrabutyrate was greater than that of riboflavin 5'-phosphate. On measuring incorporation of [3H]thymidine into EAC cells, these vitamins did not alter appreciably the magnitude of the ADR-induced suppression of DNA synthesis in EAC cells.
mesh_terms: D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics*; D003067:Coenzymes; D004261:DNA Replication / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism*; D051379:Mice; D012256:Riboflavin / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology*
chemical_list: D003067:Coenzymes; D008054:Lipid Peroxides; D014815:Vitamins; D014451:Ubiquinone; D014810:Vitamin E; D004317:Doxorubicin; C024989:coenzyme Q10; D012256:Riboflavin; D013936:Thymidine