Acute tubular dysfunction in infants with obstructive uropathy.
Eleven patients are described with severe hyponatraemia, hyperkalaemia and metabolic acidosis associated with a urinary tract infection and obstructive uropathy. This clinical entity resembles adrenocortical disorders. Urine culture investigation in combination with abdominal ultrasound examination will reveal urinary tract obstruction. Differential diagnosis, pathogenesis and treatment are discussed. In most patients correction of the metabolic disturbance can be achieved with antibiotic treatment, occasionally in combination with surgical therapy. Some degree of polyuria will generally persist.
D000138:Acidosis / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D006947:Hyperkalemia / Q000175:diagnosis; D007010:Hyponatremia / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D014551:Urinary Tract / Q000002:abnormalities; D014552:Urinary Tract Infections / Q000175:diagnosis; D014570:Urologic Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy