title: Effect of oral cholestyramine on the elimination of high-dose methotrexate.
abstract: The anion exchange resin cholestyramine binds methotrexate (MTX) effectively in vitro. The binding capacity exceeds that of activated charcoal by a factor of 5.4. On two patients undergoing high-dose MTX therapy it is also shown that cholestyramine binds MTX in vivo. This leads to an enhanced non-renal excretion of MTX. Therefore, cholestyramine may be of clinical value in patients who develop renal function impairment whilst undergoing MTX therapy.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001646:Bile / Q000378:metabolism; D002606:Charcoal / Q000494:pharmacology; D002648:Child; D002792:Cholestyramine Resin / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D002792:Cholestyramine Resin; D002606:Charcoal; D008727:Methotrexate