Common neural mechanisms in experimental chorea and hemiballismus in the monkey. Evidence from 2-deoxyglucose autoradiography.
The autoradiographic 2-deoxyglucose uptake technique was used to visualise local cerebral metabolic activity in the monkey in recently developed models of chorea and hemiballismus. Unilateral dyskinesia was induced by injection of a gamma-aminobutyric acid antagonist into the corpus striatum (in the case of chorea) or subthalamic nucleus (in the case of hemiballismus). Patterns of 2-deoxyglucose uptake suggest that during both forms of experimental dyskinesia the subthalamic nucleus and its projection to the globus pallidus are abnormally hypoactive.
D000818:Animals; D001345:Autoradiography; D001640:Bicuculline / Q000031:analogs & derivatives; D002819:Chorea / Q000378:metabolism; D004027:Diencephalon / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D008252:Macaca fascicularis; D008254:Macaca nemestrina; D009069:Movement Disorders / Q000139:chemically induced / Q000378:metabolism*; D009434:Neural Pathways / Q000378:metabolism
C017069:bicuculline methiodide; D005947:Glucose; D001640:Bicuculline