[Pharmacological actions of iprazochrome on the vascular system].
The pharmacological actions of iprazochrome (IC) on the vascular system were studied, and the following results were obtained: No death nor abnormal behaviors were observed in acute toxicity tests conducted on male and female mice and rats despite the administration of large doses of IC (10,000 mg/kg, p.o. and 80 mg/kg, i.v., respectively). IC inhibited dose-dependently platelet aggregation in vitro induced by arachidonate and ADP, whereas no effect was observed on ADP-induced respiratory depression in mice, which is closely related to platelet aggregation in vivo. The antiserotonergic actions of IC on the isolated external carotid arteries and femoral arteries in dogs observed in a noncompetitive manner were found to be 1/24 to 1/65 that of methysergide. On the other hand, IC showed no inhibitory effect on the paw edema of rats in vivo induced by serotonin. The inhibitory effect of IC on peritoneal dye leakage in mice was less than half that of phenylbutazone. IC prevented apoplexy in stroke-prone SHR (SHRSP) without lowering the blood pressure. Histological changes in the cerebrum of SHRSP were ischemic changes such as swelling of the neurons and shrinkage of the nuclei, mainly in the cerebral cortex and corpus striatum area.
D000323:Adrenochrome / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000517:prevention & control; D005260:Female; D006973:Hypertension / Q000517:prevention & control; D066298:In Vitro Techniques; D045563:Indolequinones; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D012119:Respiration / Q000187:drug effects; D012702:Serotonin Antagonists
D045563:Indolequinones; D012702:Serotonin Antagonists; D000323:Adrenochrome; C009742:iprazochrome