Prolonged severe cholestasis induced by oxacillin derivatives. A report on two cases.
Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described. The clinical course as well as the biochemical pattern and the investigation of liver biopsy specimens enabled us to establish the diagnoses of drug-induced canalicular and hepatocanalicular cholestasis.
D000328:Adult; D000368:Aged; D002779:Cholestasis / Q000139:chemically induced*; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy; D010068:Oxacillin / Q000009:adverse effects*; D013997:Time Factors
D010068:Oxacillin