Nonexpression of a major heat shock gene in mouse plasmacytoma MPC-11.
The major heat shock gene coding for a 68,000-dalton protein was found to be silent in mouse plasmacytoma MPC-11 in both control and stressed cells. The block appears to be at the level of transcription, although RNA processing or instability has not been ruled out. It is not caused by a major deletion or rearrangement of the gene.
D000818:Animals; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000235:genetics*; D006358:Hot Temperature; D051379:Mice; D008970:Molecular Weight; D010954:Plasmacytoma / Q000235:genetics*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D006360:Heat-Shock Proteins; D012333:RNA, Messenger