Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick.
Chlorpromazine and trifluoperazine HCl, antipsychotic drugs known to bind to calmodulin, reversibly inhibited elevation of neural folds by interfering with the contractile activity of apical microfilament bundles in developing chick neuroepithelial cells.
D008841:Actin Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D002147:Calmodulin / Q000502:physiology*; D002642:Chick Embryo; D002746:Chlorpromazine / Q000494:pharmacology; D004847:Epithelial Cells; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009432:Neural Crest / Q000648:ultrastructure*; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D014268:Trifluoperazine; D002746:Chlorpromazine