[Acute mucosal damage of the stomach of the Wistar rat and its prevention with the drug combination droperidol/atropine--an animal experiment study].
The employment of the alpha receptor blocking Droperidol with and without combination of atropine for prophylaxis of the acute mucosal damage of the stomach was investigated in the experimental animal Wistar rat. The immobilisation stress in the stress roll was chosen as stress model. The animals get an infusion programme by a central venous catheter. The stomachs were searched for macroscopic mucosal changes after an immobilisation period of 6 hours. The results were certained statistically. The acute mucosal damage in the rat stomach could be prevented in 100% (p 0.05) by means of the drug combination Droperidol/atropine (IV).
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications*
D001285:Atropine; D004329:Droperidol
Der akute Schleimhautschaden des Magens der Wistar-Ratte und dessen Prophylaxe mit der Pharmakakombination Droperidol/Atropin - eine tierexperimentelle Untersuchung.