title: [2 + 2] photocycloadditions in the synthesis of chiral molecules.
abstract: A strategy for the synthesis of chiral molecules that receives growing popularity among organic chemists employs the photochemically mediated [2 + 2] cycloaddition reaction. These reactions can be performed on a multigram scale and often proceed with high yield and with stereocontrol. These features, in combination with the useful properties of the four-membered ring photoproducts in subsequent chemical transformations, make them attractive options in the early stage of a synthesis design. Various combinations of unsaturated functional groups can participate in this reaction process. Accordingly, these chemical reactions can be economical solutions to problems relating to the synthesis of a variety of target molecules.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000935:Antifungal Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D003058:Cockroaches; D005260:Female; D005663:Furans / Q000138:chemical synthesis; D007783:Lactones / Q000138:chemical synthesis; D008297:Male; D009183:Mycotoxins / Q000138:chemical synthesis; D010777:Photochemistry; D011753:Pyrones / Q000138:chemical synthesis; D012724:Sex Attractants / Q000138:chemical synthesis / Q000302:isolation & purification; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D007783:Lactones; D009183:Mycotoxins; D011753:Pyrones; D012724:Sex Attractants; C100081:avenaciolide; C030923:asteltoxin