[Effect of cyclophosphane on lipid peroxidation].
Single and repeated treatment with toxic doses of cyclophosphamide was shown to activate peroxidation of lipids of myocardial, pulmonary, hepatic and renal cell membranes. An antioxidant-silymarin-inhibited the prooxidating effect of cyclophosphamide thus suggesting further studies of antioxidants as means for counteracting the adverse effects of cytostatic drugs.
D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D012838:Silymarin / Q000494:pharmacology
D008054:Lipid Peroxides; D012838:Silymarin; D008315:Malondialdehyde; D003520:Cyclophosphamide
Vliianie tsiklofosfana na perekisnoe okislenie lipidov.