Rhinocerebral mucormycosis in a diabetic ketoacidotic patient.
A 51-year-old, ketoacidotic diabetic with the rare neurological complications of rhinocerebral mucormycosis is reported. The clinical presentation was characterized by initial severe frontal headache, rapid visual loss with complete external ophthalmoplegia and intracranial spread by invasive fungal growth. Its course and fungostatic therapy with amphotericin B and ketoconazole are described and the literature reviewed.
D000138:Acidosis / Q000209:etiology*; D000666:Amphotericin B / Q000627:therapeutic use; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D007657:Ketone Bodies / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D010254:Paranasal Sinus Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D014057:Tomography, X-Ray Computed
D007657:Ketone Bodies; D000666:Amphotericin B; D007654:Ketoconazole