Comparative in vitro activity of temocillin.
The antibacterial activity of temocillin, a novel beta-lactam antibiotic, was tested against 796 clinical isolates. We also conducted a comparative study against 8 other antibiotics. Temocillin exhibited good activity against Gram-negative organisms including Escherichia coli, and the genera Proteus, Enterobacter, Serratia, Klebsiella, Citrobacter, Providencia, Salmonella, Shigella and Haemophilus: 98% of the strains were inhibited by concentrations less than or equal to 16 mg/L. The results of this in vitro study and temocillin's favourable pharmacokinetic properties suggest that temocillin is a very promising penicillin for the treatment of hospital infections caused by Gram-negative organisms.
D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D013045:Species Specificity
D010406:Penicillins; C031367:temocillin