title: [Mathematical modeling of the dynamics of the intensity of the mutation process. I. Formulation of the task and the general model].
abstract: Methodology is devised to construct dynamic models of the mutation process intensity under quasi-stationary environmental conditions and limited experimental information. Laws of distribution of unknown parameters of dynamic models and prognostic values of inherited pathology frequencies were determined for the cases of normal distribution with zero mathematical expectancy and constant dispersion of casual environmental influence. Given is the algorithm of dynamic model construction on frequencies of inherited pathology, using experimental data and on the basis of determination of permissible intervals for their prognostic values.
mesh_terms: D001499:Bayes Theorem; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D011379:Prognosis
vernacular_title: Matematicheskoe modelirovanie dinamiki intensivnosti mutatsionnogo protsessa. Soobshchenie I. Postanovka zadachi i obshchaia model'.