title: Role of the uterine cervix in inhibition of sexual behaviour in lactating rats.
abstract: Treatment of ovariectomized rats with progesterone-filled constant-release implants, which increased serum progesterone concentrations to 99.4 +/- 5.0 nmol/l, facilitated the induction of lordosis behaviour by subsequent treatment with oestradiol benzoate (OB, 10 micrograms). Concurrent treatment with the dopamine receptor antagonist domperidone (two daily injections of 2.5 mg/rat), which increased serum prolactin concentrations, did not inhibit the behavioural response of ovariectomized progesterone-treated rats to OB. If the treatment was combined with stimulation of the uterine cervix it inhibited lordosis to a level which was comparable with that of progesterone-domperidone-treated rats, which had been ovariectomized and from which the pups had been removed on the day of parturition. The cervical stimulation did not increase the amount of prolactin secreted by the pituitary gland in response to an injection of domperidone. The behavioural effect of cervical stimulation was blocked by injecting an anaesthetic paste (0.1 ml lidocain-prilocain) intravaginally against the cervix. The effect of cervical stimulation, or of parturition, lasted only for a few days and sexual behaviour was inhibited during a prolonged period of lactation. Sucking by the pups on the nipples of the mother may be required for preventing sexual behaviour during the entire period of lactation.
mesh_terms: D000772:Anesthesia, Local; D000818:Animals; D002369:Castration; D002584:Cervix Uteri / Q000502:physiology*; D004294:Domperidone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007774:Lactation; D010812:Physical Stimulation; D011247:Pregnancy; D011374:Progesterone / Q000097:blood / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects
chemical_list: D011374:Progesterone; D004958:Estradiol; D004294:Domperidone; D011388:Prolactin