Prolactin analgesia: tolerance and cross-tolerance with morphine.
The development of acute tolerance to prolactin-induced analgesia in mice was identified by using the writhing test. This tolerance was antagonised by naltrexone pretreatment indicating a role of an opioid mechanism. Cross-tolerance between morphine and prolactin was observed with regard to analgesia. These data show that prolactin mimics morphine properties as far as analgesia is concerned and serve as evidence supporting prolactin-opioid interaction.
D000700:Analgesics; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology*
D000700:Analgesics; D001971:Bromocriptine; D009271:Naltrexone; D009020:Morphine; D011388:Prolactin