[Chromatin degradation during the exposure of thymus lymphocytes in vitro to differentiation inducers and gamma irradiation].
Chemical inductors of differentiation were shown to cause chromatin degradation in thymus lymphocytes. This process was prevented by the protein synthesis inhibitors. The fragments formed after the effect of chemical differentiation inductors on thymocytes were fully identical to chromatin internucleosome degradation products formed in the exposed cells. Chromatin degradation under the effect of chemical differentiation inductors was most pronounced in a more radiosensitive thymocyte fraction.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects* / Q000528:radiation effects; D005720:Gamma Rays; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects
D002843:Chromatin
Degradatsiia khromatina pri deĭstvii induktorov differentsirovki i gamma-oblucheniia na limfotsity timusa in vitro.