[Radioprotective action of catecholamines on a Chinese hamster fibroblast culture].
The radioprotective ability of adrenaline, noradrenaline and isoproterenol in various concentrations has been studied in experiments on cultured Chinese hamster fibroblasts in vitro. Radioprotective effect of isoproterenol is pronounced at 10(-8)M concentration; adrenaline and especially noradrenaline are effective at higher concentrations. The antagonist of beta-adrenergic receptors propranolol blocks the radioprotective effect of catecholamines on cells. The beta-adrenergic mechanism of catecholamines radioprotective action on the mammals cells is under discussion.
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011837:Radiation-Protective Agents
D002395:Catecholamines; D011837:Radiation-Protective Agents; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
Radiozashchitnoe deĭstvie katekholaminov na kul'turu fibroblastov kitaĭskogo khomiachka.