title: Alteration in the postnatal ontogeny of cerebellar norepinephrine content following chronic prenatal carbon monoxide.
abstract: The postnatal ontogeny of norepinephrine content in the cortex and cerebellum was determined in rats exposed prenatally to a chronic low level of carbon monoxide (150 parts per million). In the cerebellum, norepinephrine concentration and total norepinephrine content among carbon monoxide-exposed rats were consistently elevated over that of control rats from the second through the sixth postnatal weeks. In the cortex, norepinephrine concentration and total norepinephrine content among carbon monoxide-exposed rats did not differ from that of control rats over the same period. These results identify the cerebellum as a region whose postnatal development is altered by prenatal exposure to low levels of carbon monoxide-induced hypoxia.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002248:Carbon Monoxide / Q000494:pharmacology*; D002531:Cerebellum / Q000032:analysis / Q000254:growth & development*; D002540:Cerebral Cortex / Q000032:analysis / Q000254:growth & development; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000032:analysis*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
chemical_list: D002248:Carbon Monoxide; D009638:Norepinephrine