The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.
Syrian golden hamsters fed diets of raw or heated soy flour for 16 months had an incidence (4%) of pancreatic neoplasms in both groups. Animals injected with N-nitrosobis (2-oxopropyl) amine (BOP) and fed heated soy flour for 15 months developed a high incidence (88%) of microscopic benign and malignant neoplasms, primarily of ductal origin. This was in marked contrast to a similar group of BOP-injected animals which had been fed raw soy flour and in which the incidence of pancreatic neoplasms was less than 10%.
D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D005433:Flour; D006358:Hot Temperature; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology; D013025:Glycine max
D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine