[New concepts of microsomal metabolism of the antibiotic adriamycin].
Experimental and literary data are presented which are at variance with the known conception of adriamycin (AD) shunting the chain of microsomal electron transfer. AD, carminomycin, rubomycin, mitomycin C, and coenzyme Q9 are shown to interact with NADPH, in the absence of enzymes, with the nucleotide oxidation. A new scheme of AD metabolism is suggested, according to which AD in the hydroquinone form enters the chain of electron transfer in microsomes between NADPH and flavoprotein.
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004579:Electron Transport; D006801:Humans; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism*; D008954:Models, Biological; D009249:NADP / Q000378:metabolism
D009249:NADP; D004317:Doxorubicin; D003577:Cytochrome P-450 Enzyme System
Novoe predstavlenie o mikrosomnom metabolizme antibiotika adriamitsina.