Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma.
Prostaglandin E1 (PGE1) and platelet activation factor (PAF) were found respectively to activate or to inhibit cholesterol esterification in whole plasma but not in lipoprotein-deficient plasma. It is suggested that these effects are mediated by the interaction of PGE1 and PAF with high-density lipoproteins [(1984) FEBS Lett. 173, 291-294]. Possible physiological implications of these findings are discussed.
D000527:Alprostadil / Q000494:pharmacology; D002788:Cholesterol Esters / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000172:deficiency; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*
D002788:Cholesterol Esters; D008074:Lipoproteins; D010972:Platelet Activating Factor; D011453:Prostaglandins; D000527:Alprostadil