title: A simple technique to simultaneously assess activity at histamine H1- and H2-receptors in vivo.
abstract: A technique is described that allows simultaneous and quantitative assay of the action of agonists and antagonists at histamine H1- and H2-receptors in anesthetized guinea pigs. The principle of the technique is based on H1-receptor bronchoconstriction and H2-receptor tachycardia. Studies have been made to assay antagonists at either receptor and provide simultaneous evidence of selectivity or to assay combined antagonists such as Smith Kline & French 93319. Studies with histamine receptor agonists provide evidence of the potency and selectivity of these compounds relative to histamine.
mesh_terms: D000818:Animals; D001621:Betahistine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D008297:Male; D011738:Pyrilamine / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*
chemical_list: D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002927:Cimetidine; D006632:Histamine; D011738:Pyrilamine; D001621:Betahistine