title: Lack of effect of highly purified subunit influenza vaccination on theophylline metabolism.
abstract: Plasma concentrations of theophylline, and urinary recovery of theophylline and its metabolites [1, 3-dimethyluric acid, 3-methyl xanthine and 1-methyluric acid] were measured before and after highly purified subunit influenza vaccination in seven healthy subjects, and five subjects with chronic obstructive bronchitis. No cases of theophylline toxicity were seen, and there was no increase in mean plasma theophylline concentration or significant decrease in urinary metabolite concentration after vaccination. An antibody response to vaccination was demonstrated in all subjects. Highly purified subunit influenza vaccination may be given with safety to patients on theophylline.
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000096:biosynthesis; D001991:Bronchitis / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology; D013806:Theophylline / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D013806:Theophylline