[Pharmacokinetics of ampicillin in patients with chronic renal insufficiency during hemodialysis and hemosorption].
It was shown that when the filtration capacity of the kidneys was lowered even insignificantly (the creatinine clearance 50-80 ml/min), the maximum blood levels of ampicillin increased 2 times and its retention time was prolonged. At the terminal stage of chronic renal insufficiency the half-life of the drug and the area under the pharmacokinetic curve markedly increased and the plasma clearance decreased. Hemodialysis and hemosorption significantly lowered the ampicillin half-life. The ampicillin coefficient in hemosorption was 2 times higher than that in hemodialysis.
D000667:Ampicillin / Q000378:metabolism*; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D006435:Renal Dialysis; D013997:Time Factors
D000667:Ampicillin
Farmakokinetika ampitsillina u bol'nykh khronicheskoĭ pochechnoĭ nedostatochnost'iu v usloviiakh gemodializa i gemosorbtsii.