title: [Modifying effect of thyroid gland functional disorders on realization of transplacental carcinogenesis induced by N-nitrosomethylurea in rats].
abstract: The paper discusses the influence of deranged function of the thyroid (in postnatal period) on the transplacental carcinogenic effect of N-nitrosomethylurea (NMU) in albino noninbred rats. It was found that exogenous thyroxin-induced hyperthyroidism and thyroid function suppression either by long-term treatment with a thyreostatic agent--methylthiouracil (MTU) or thyroidectomy are followed by a lower frequency of, chiefly, nervous system tumors which are typical of NMU-induced transplacental carcinogenesis in rats. Moreover, transplacental treatment with NMU potentiated the carcinogenic effect of MTU on the thyroid. The latter manifested itself in a higher frequency of malignancies of the thyroid in animals exposed to a combined treatment with NMU (transplacentally) and MTU (postnatally) as compared with those given MTU only (postnatally).
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced; D005260:Female; D008431:Maternal-Fetal Exchange; D008770:Methylnitrosourea; D008779:Methylthiouracil / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011247:Pregnancy; D051381:Rats; D013961:Thyroid Gland / Q000502:physiology*; D013964:Thyroid Neoplasms / Q000139:chemically induced; D013965:Thyroidectomy; D013974:Thyroxine / Q000633:toxicity
chemical_list: D008770:Methylnitrosourea; D013974:Thyroxine; D008779:Methylthiouracil
vernacular_title: Modifitsiruiushchee vliianie narusheniia funktsii shchitovidnoĭ zhelezy na realizatsiiu transplatsentarnogo kantserogeneza, indutsirovannogo N-nitrozometilmochevinoĭ u krys.