Synthesis and preliminary in-vitro profile of Sch 34343--a new penem antibacterial agent.
Sch 34343, a new penem antibiotic, has been synthesized by several routes and found to be highly active against both aerobic and anaerobic Gram-positive and Gram-negative organisms (except Pseudomonas). It has excellent beta-lactamase stability and is bactericidal. The synthetic routes to Sch 34343 and its in-vitro activity compared with other structurally related penems are discussed.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D007769:Lactams; D011549:Pseudomonas / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007769:Lactams; C044617:Sch 34343