[Vascular component of the fibrinolytic system of blood (plasminogen activator of vascular wall) in patients with duodenal ulcer with a history of hemorrhagic complications].
It has been established that patients with duodenal ulcer complicated by hemorrhage in the past are characterized by the low response of the fibrinolytic system (FS) to two different exposures--local venous occlusion and administration of the sympathomimetic alupent. The rate of plasminogen the lower limit of normal in almost 2/3 of patients with activator release (RPAR) from vascular depots was under hemorrhages and in 1/4 of those with uncomplicated duodenal ulcer. The low RPAR was coupled with hereditary aggravation and hyperplasia of the parietal glandulocytes of the stomach. In duodenal ulcer complicated by hemorrhages, the normal parameters of the fibrinolysis kinetics and RPAR were encountered 3 times less frequently than in uncomplicated duodenal ulcer, whereas activated blood fibrinolysis coupled with the low RPAR 5 times as frequently. The shifts can severe a discriminant prognostic criterion painting to a potential risk of hemorrhage and making it possible to carry out the different prophylaxis. The treatment with epsilon-aminocaprotic acid given in courses makes the FS including its vascular component return to normal.
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000097:blood* / Q000150:complications; D005260:Female; D005342:Fibrinolysis; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000209:etiology*; D010960:Plasminogen Activators / Q000172:deficiency / Q000378:metabolism*; D012306:Risk; D014680:Veins / Q000378:metabolism*
D010960:Plasminogen Activators
Sosudistyĭ komponent fibrinoliticheskoĭ sistemy krovi (aktivator plazminogena sosudistoĭ stenki) u bol'nykh iazvennoĭ bolezn'iu dvenadtsatiperstnoĭ kishki s gemorragicheskimi oslozhneniiami v anamneze.