Increase in blood pressure in pheochromocytoma induced by domperidone and metoclopramide.
Administration of two dopamine antagonists, domperidone and metoclopramide, gave a marked rise in blood pressure with an increase in plasma catecholamines in two patients with pheochromocytoma. The result suggests that not only metoclopramide but also domperidone might induce hypertensive crisis in pheochromocytoma.
D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004294:Domperidone / Q000009:adverse effects* / Q000627:therapeutic use; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D010673:Pheochromocytoma / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D004294:Domperidone; D008787:Metoclopramide; D009638:Norepinephrine; D004837:Epinephrine