title: Cefotaxime diffusion into cerebrospinal fluid of children with meningitis.
abstract: Cefotaxime diffused consistently and in therapeutic levels into the cerebrospinal fluid (CSF) of 13 children successfully treated for bacterial meningitis. CSF cefotaxime levels early (6.0 micrograms/ml) and late (1.2 micrograms/ml) in treatment were severalfold the MBCs for the infecting organisms. After a single 40-mg/kg dose to each of five infants with ventriculostomies, mean CSF levels of cefotaxime were 6.4, 5.7, and 4.5 micrograms/ml at 2, 4, and 6 h, respectively.
mesh_terms: D002439:Cefotaxime / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D006801:Humans; D007223:Infant; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008826:Microbial Sensitivity Tests
chemical_list: D002439:Cefotaxime