Pharmacokinetics of Josamycin in patients with liver cirrhosis and Gilbert's syndrome after repeated doses.
The pharmacokinetics of Josamycin was studied in 31 subjects (10 normals, 9 Gilbert's syndrome and 12 compensated liver cirrhosis) after the administration of Josamycin (1 g orally) and in 13 subjects (4 normals, 4 Gilbert's syndrome and 5 compensated liver cirrhosis) after 3-day Josamycin treatment (1 g orally every 12 hours). Josamycin pharmacokinetics was impaired in liver cirrhosis and, to a lesser extent, in Gilbert's syndrome. Moreover, in the three groups of individuals studied the drug accumulated after multiple dosing. These results suggest that a dosage adjustment of Josamycin is recommended when dealing with these patients.
D000328:Adult; D005260:Female; D005878:Gilbert Disease / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006933:Hyperbilirubinemia, Hereditary / Q000188:drug therapy*; D007700:Kinetics; D007933:Leucomycins / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007933:Leucomycins