title: Ultrastructure of cellular changes in the replication of the alcelaphine herpesvirus-1 of malignant catarrhal fever.
abstract: Cell cultures inoculated with 5 different viral isolates from 4 species of ruminants with clinical signs of malignant catarrhal fever (from the San Diego Wild Animal Park) were examined by electron microscopy. Each had the morphology of a herpesvirus (118 to 220 nm) and was icosahedral, and the nucleocapsid matured in the nucleus of the infected cell. Envelopment of budding occurred with each viral isolate at the nuclear and the plasma membranes. The virions egressed from the cell by budding from the plasma membrane or through channels of the Golgi apparatus or the endoplasmic reticulum. A proposed scheme for the morphogenesis of the herpesvirus of malignant catarrhal fever is presented.
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D001188:Artiodactyla; D002417:Cattle; D002460:Cell Line; D002467:Cell Nucleus / Q000382:microbiology; D003588:Cytopathogenic Effect, Viral; D005260:Female; D006564:Herpesviridae / Q000254:growth & development* / Q000648:ultrastructure; D007668:Kidney; D008297:Male; D008304:Malignant Catarrh / Q000382:microbiology*; D008854:Microscopy, Electron; D009024:Morphogenesis; D013045:Species Specificity; D014779:Virus Replication