[Possibilities of using neurotropic agents for preventing the development of aphthous stomatitis].
Aphthous lesions of the oral mucosa were simulated in dogs by common bile duct ligation. In one of the experimental groups, the animals were administered the beta-adrenoblocker obsidan 30 min before operation. Two hours after operation the regions of the oral mucosa mostly affected by aphthous lesions were examined for the content of adrenaline and noradrenaline (NA). The data obtained indicate a significant increase in the content of NA and adrenaline in the oral mucosa 2 h following operation. In animals pretreated with obsidan, the content of catecholamines remained at the level seen in the control group. Therefore, blocking the transmission of nerve impulses to the sympathetic nervous system obsidan interferes with the reflex influence from the involved organs of the abdominal cavity, thereby protecting the oral mucosa tissues from the damage-inducing action of high concentrations of NA.
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism; D011433:Propranolol / Q000627:therapeutic use*; D013281:Stomatitis, Aphthous / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
D011433:Propranolol; D009638:Norepinephrine; D004837:Epinephrine
Vozmozhnosti primeneniia neĭrotropnykh sredstv dlia predotvrashcheniia razvitiia aftoznykh stomatitov.