The role of urea in albumin dimerisation in nephrotic urines.
Albumin dimerisation in nephrotic urine frozen to -20 degrees C occurs at low ionic strength in the presence of quite low concentrations of urea (greater than 0.2 mol/l). Urea will also dimerize normal serum albumin under these conditions. The appearance of dimer in patients with a nephrotic syndrome treated with steroids is significantly correlated (p less than 0.001) with an increase in urinary urea concentration.
D000419:Albuminuria / Q000652:urine*; D004553:Electric Conductivity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances; D008954:Models, Biological; D009404:Nephrotic Syndrome / Q000652:urine*; D014462:Ultrafiltration; D014508:Urea / Q000652:urine*
D046911:Macromolecular Substances; D014508:Urea