title: Selective expression of glutathione transferase isoenzymes in chemically induced preneoplastic rat hepatocyte nodules.
abstract: Isoenzymes of glutathione transferase were shown to occur at selectively altered levels in rat hepatocyte nodules produced by 2-acetylaminofluorene treatment. Changes were measured by different substrates, antibodies raised against purified glutathione transferases, and by purification of the major isoenzymes. Isoenzymes composed of subunits 1, 2 and 3, expressed in normal liver tissue, all occurred at increased concentrations in nodules, whereas the level of transferase 4-4 was decreased. The most conspicuous change was the appearance of glutathione transferase 7-7 (or transferase P), the concentration of which in negligible in normal liver.
mesh_terms: D015073:2-Acetylaminofluorene / Q000494:pharmacology; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D005982:Glutathione Transferase / Q000096:biosynthesis*; D007527:Isoenzymes / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011230:Precancerous Conditions / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007527:Isoenzymes; D015073:2-Acetylaminofluorene; D005982:Glutathione Transferase