title: [Long-term toxicological studies with mizoribine (Bredinin) in beagle dogs (the second report). Pathological studies on visceral organs].
abstract: Four Beagle dogs were administrated with mizoribine 2.5 mg/kg/day for 36 months. Clinical and laboratory findings were fully described in the first report, in which no remarkable abnormalities were detected. Visceral organs of the experimental group and non-treated control group were submitted for pathological investigations. No conspicuous macroscopical and microscopical drug-induced changes were disclosed in the experimental group.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012263:Ribonucleosides / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine