[Structural characteristics of DNA from the rat liver during inhibition of protein synthesis with cycloheximide].
At cot around 20, the rat liver DNA reassociation curves were obtained 12-48 hours after injection of the animals with sublethal doses of cycloheximide. In total preparations of DNA-24 and DNA-36 at cot 0.02-0.06, the number of fast reassociating sequences was increased, on the average, by 4%. The differences in reassociation rates for individual kinetic fractions are 2.5-3-fold. The total incorporation of the label into DNA-24 preparations is sharply decreased; however, a marked distinction in the incorporation between the fractions in parameter cot was observed.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology* / Q000633:toxicity; D004247:DNA / Q000032:analysis* / Q000235:genetics; D007700:Kinetics; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D012091:Repetitive Sequences, Nucleic Acid
D004247:DNA; D003513:Cycloheximide
O strukturnykh osobennostiakh DNK pecheni krys v protsesse ingibirovaniia belkovogo sinteza tsiklogeksimidom.