Relationship between the age of platelets and their megakaryocytopoiesis-inhibiting effect.
Homogenate made from young platelets suppressed thrombocytopoiesis in mice more effectively than homogenate made from old platelets. To achieve the same suppressive effect as that of young platelets, homogenate made from twice as many old platelets were needed.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology*; D002470:Cell Survival; D006410:Hematopoiesis; D008533:Megakaryocytes / Q000166:cytology*; D051379:Mice; D013997:Time Factors