Chemiluminescence and superoxide dismutase in the plasma in patients with alcoholic and non-alcoholic liver injuries.
The chemiluminescence level and superoxide dismutase (SOD) activity were determined in the plasma of patients with alcoholic and non-alcoholic liver injuries. Chemiluminescence level was significantly higher in alcoholics than in non-alcoholics. It increased significantly in patients with fatty livers and had a tendency to increase with the progression of alcoholic liver injury from a fatty liver to liver cirrhosis. Mn-SOD activity was elevated in patients with alcoholic liver injuries. Furthermore, there was a positive correlation between the levels of plasma chemiluminescence and plasma Mn-SOD activity. The increases in chemiluminescence and Mn-SOD activity suggests that the generation of a large amount of activated oxygen is associated with the pathogenesis and progression of alcoholic liver injury in humans.
D000328:Adult; D001706:Biopsy; D005234:Fatty Liver / Q000201:enzymology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology*; D008108:Liver Diseases, Alcoholic / Q000201:enzymology*; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase