title: Biosensors and the clinical laboratory.
abstract: Aside from the economic factors that make biosensors attractive, on-board signal conditioning and signal processing improve the limits of detection and simplify use of the devices. The present discussion summarizes the breadth of biosensor design and application, and the requirements of clinical assay detection. Current sensor research is aimed toward extending the lower limits of detection for nonradioactive immunoassays. The clinical laboratory is in a state of change; operating and instrumentation costs will affect the delivery of diagnostics. Technology will assume a major role in reshaping the clinical laboratory. Biosensors promise to deliver the diagnostic tools for the evolution that is now in progress. The clinical laboratory will no doubt continue to perform chemical profiling and the more specialized tests. The successful implementation of solid-state sensor technology promises to simplify immunoassay procedures, as the autoanalyzer did some 20 years ago for the profiling of blood metabolites. It is likely that more tests will be performed in physicians' offices with the advent of highly automated and cost-effective biosensors. By the use of this technology, practitioners of critical care medicine will be able to assume greater responsibility for diagnostic testing.
mesh_terms: D019411:Clinical Laboratory Techniques / Q000295:instrumentation*; D004274:DNA, Recombinant; D004582:Electronics, Medical; D006801:Humans; D007118:Immunoassay; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D012666:Semiconductors; D014173:Transistors, Electronic
chemical_list: D004274:DNA, Recombinant