Antibodies against animal growth hormones appearing in patients treated with human growth hormone: their specificities and influence on growth velocity.
The appearance of anti-human growth hormone (hGH) and anti-non-hGHs antibodies in 27 patients with idiopathic hypopituitarism, treated for periods of 6-18 months with three different preparations of hGH, was investigated. The preparations induced antibodies to GH in 21 out of the 27 patients: 10 patients produced exclusively an anti-non-hGH response, whereas 11 generated both anti-non-hGH and anti-hGH antibodies. The levels of antibodies against hGH had low correlation with decreased growth velocity, whereas those for the antibodies against non-hGHs did not correlate with decreased growth velocity.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation / Q000187:drug effects; D000918:Antibody Specificity; D002417:Cattle; D002648:Child; D003429:Cross Reactions; D005260:Female; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000276:immunology* / Q000627:therapeutic use; D006736:Horses; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy; D008297:Male; D012756:Sheep
D000906:Antibodies; D013006:Growth Hormone