title: Synthesis of several new carbapenem antibiotics.
abstract: A synthesis of several carbapenem antibiotics including 9-methoxythienamycin is described. The final deprotection of C-3 esters was accomplished by a novel procedure using aluminum trichloride under a very mild condition. The antibacterial activity against Gram-positive and Gram-negative bacteria is shown.
mesh_terms: D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013845:Thienamycins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D013845:Thienamycins