Age-dependent changes of rat liver plasma membrane composition.
The chemical composition of liver plasma membrane was studied in Wistar rats aged between 3 and 24 months. Results obtained indicate a significant age-dependent positive correlation of both the protein: phospholipid and cholesterol: phospholipid ratios, whereas the protein: cholesterol ratio seems to remain unaffected. Phospholipid analysis of liver plasma membrane reveals that only the phosphatidylcholine content has a significant negative correlation with age; all other phospholipid species remain basically unchanged.
D000375:Aging; D000818:Animals; D002462:Cell Membrane / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D008099:Liver / Q000166:cytology*; D008297:Male; D008560:Membrane Fluidity; D008563:Membrane Lipids / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D008563:Membrane Lipids; D008565:Membrane Proteins; D002784:Cholesterol