Screening for endometrial carcinoma by endouterine aspiration cytology with analysis of tumor markers in the aspirates. Development and application of a new screening technique.
A new endometrial aspiration technique for office screening of endometrial carcinoma without an anesthesia was studied. In patients without apparent signs of cervical canal stenosis, all of whom were 50 years of age or older, the aspiration attempt was successful in 96%. The aspirates were used for cytologic study and tumor marker assays. The results indicate that screening for endometrial carcinoma should be based on the determination of biochemical tumor markers in the uterine fluid. Lactate dehydrogenase (LD) is recommended as a primary marker, determined as total LD and as LD isoenzyme activity. Endometrial cytology is recommended as a supplementary screening technique in selected cases.
D000368:Aged; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010960:Plasminogen Activators / Q000032:analysis; D013396:Suction; D014594:Uterine Neoplasms / Q000032:analysis / Q000201:enzymology / Q000473:pathology*
D005338:Fibrin Fibrinogen Degradation Products; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D010960:Plasminogen Activators