Oral water causes emptying of the human gallbladder through actions of vagal stimuli rather than motilin.
A drink of water was found to cause partial emptying of the human gallbladder in parallel with the release of motilin. The water-induced effect on the gallbladder was abolished by atropine, whereas the release of motilin remained unchanged. Exogenous infusions of porcine motilin aimed at achieving either a physiological or a pharmacological plasma motilin increment were both without effect on gallbladder dynamics as compared with saline infusions. It is concluded that the water-induced gallbladder emptying is vagally dependent. Furthermore, the results suggest that motilin does not cause gallbladder emptying in man.
D000328:Adult; D001285:Atropine / Q000494:pharmacology; D004326:Drinking; D005260:Female; D005704:Gallbladder / Q000294:innervation / Q000502:physiology*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009037:Motilin / Q000378:metabolism* / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D014630:Vagus Nerve / Q000502:physiology*; D014867:Water / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D014867:Water; D009037:Motilin; D001285:Atropine