[Rectal absorption of steroids].
The investigations were designed to evaluate the systemic absorption of two steroids from suppositories. The suppositories containing either 3H-hydrocortisone (1 mg) or 3H-prednisolone-21-hexanoate (1 mg) were administered to a group of 4 baboons restrained in chairs. The levels of radio-activity in the plasma and urine were measured up to 120 h following rectal administration, and these levels were compared with those of a subsequent intravenous administration (1 mg each). The results show that both hydrocortisone (H) and prednisolone-21-hexanoate (P) are rapidly (tmax = 2-3 h) and significantly (H: 60-78%, P: 47-58%) absorbed from suppositories and thus can also cause systemic effects.
D000818:Animals; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D010215:Papio; D011239:Prednisolone / Q000097:blood / Q000378:metabolism; D012007:Rectum / Q000378:metabolism*; D013256:Steroids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013488:Suppositories
D013256:Steroids; D013488:Suppositories; D011239:Prednisolone; D006854:Hydrocortisone
Zur rektalen Resorption von Steroiden.