Changes in colonic motility during the development of chronic large bowel obstruction.
The effect of chronic progressive distal large bowel obstruction on colonic motility was studied in six mini-pigs. Motility was detected in vivo during the development of obstruction with chronically implanted Ag/AgCl electrodes using an impedance technique. When the obstruction was complete the segments of bowel were resected and spontaneous contractile activity and response to cholinergic stimulation were studied in an organ bath. Any hypermotility resulting from obstruction was shortlived and a gradual state of hypomotility supervened proximal to the obstruction. Decompression of the bowel did not result in the immediate return of motility and the resected bowel was unresponsive to carbachol. These results suggest that spontaneous resolution of large bowel obstruction is unlikely and that motility disturbances are unlikely to be a cause of anastomotic dehiscence.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002908:Chronic Disease; D003106:Colon / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D066298:In Vitro Techniques; D007415:Intestinal Obstruction / Q000503:physiopathology*; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D002217:Carbachol