Parathyroid hormone-like bioactivity in a patient with severe osteitis fibrosa cystica due to malignancy: renotropic actions of a tumour extract as assessed by cytochemical bioassay.
A patient is described with malignancy, hypercalcaemia and radiological evidence of severe parathyroid bone disease but undetectable concentrations of circulating immunoreactive PTH. Autopsy showed the tumour to be a metastatic bronchial carcinoid with no evidence of primary parathyroid disease. Extracts of the tumour had no PTH immunoreactivity but had high concentrations of a substance with identical activity to PTH in a cytochemical bioassay. The biological activity of the extract was not inhibited by PTH antibodies but was inhibited by an antagonist to PTH bioactivity.
D000368:Aged; D000818:Animals; D001984:Bronchial Neoplasms / Q000378:metabolism / Q000556:secondary*; D002276:Carcinoid Tumor / Q000378:metabolism / Q000556:secondary*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010002:Osteitis Fibrosa Cystica / Q000209:etiology / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011863:Radioimmunoassay; D014020:Tissue Extracts / Q000378:metabolism*
D010281:Parathyroid Hormone; D014020:Tissue Extracts