title: Synthesis of new arylanalogs of ketamine.
abstract: New, seven-step synthesis of arylanalogs of ketamine, starting from easily available phenylcyclohexane derivatives, is reported. Pharmacological investigations on the compounds obtained are described.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001522:Behavior, Animal / Q000187:drug effects; D001763:Blepharoptosis / Q000139:chemically induced; D001831:Body Temperature / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D007649:Ketamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010830:Physostigmine / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D007649:Ketamine; D012110:Reserpine; D010830:Physostigmine; D000661:Amphetamine