title: Immunopathology of Schistosoma japonicum infection in athymic mice.
abstract: Athymic (nu/nu) mice and heterozygous littermate controls (nu/+) were examined 7 and 10 weeks after infection with 10 cercariae of Schistosoma japonicum. Schistosome infection developed normally in both groups of mice and eggs were produced in normal numbers. Nu/nu mice developed small circumoval granulomas with minimal fibrosis while nu/+ mice developed large fibrotic granulomas. Unlike the mononuclear responses to S. mansoni eggs at 7 weeks, those to S. japonicum often were abscess like with narrow rims of liver cell necrosis or microvesicular fatty change. However, evolving granulomas in nu/+ mice were enriched with eosinophils, epithelioid macrophages, immature granulocytes and plasma cells, all scarce in the corresponding nu/nu lesions as were fibroblasts and collagen fibres, thus accounting for their smaller mean size and better healing. Our aggregate evidence shows that normal granuloma formation and cellularity in S. japonicum infection is controlled by T-cells as is the case for S. mansoni, and not by antibodies or immune complexes.
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D005260:Female; D006099:Granuloma / Q000473:pathology; D006579:Heterozygote; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology* / Q000469:parasitology; D010270:Parasite Egg Count; D012549:Schistosoma japonicum / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology* / Q000473:pathology; D013997:Time Factors
chemical_list: D000953:Antigens, Protozoan