Disturbance of methyl group metabolism in alloxan-diabetic sheep.
Alloxan-induced diabetes results in changes in the activities of a number of enzymes related to methyl group metabolism in sheep. Decreases in the activities of phospholipid methyltransferase and betaine-homocysteine methyltransferase in diabetic sheep liver indicate a reduced rate of choline synthesis and oxidation. A 65-fold increase in the activity of glycine methyltransferase and a 4-fold rise in the activity of gamma-cystathionase in diabetic sheep liver with elevated urinary excretion of cyst(e)ine suggest that catabolism of the methyl group of methionine and homocysteine was enhanced in the diabetic state.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000378:metabolism; D000818:Animals; D050940:Betaine-Homocysteine S-Methyltransferase; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism*; D050938:Glycine N-Methyltransferase; D050937:Guanidinoacetate N-Methyltransferase; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008780:Methyltransferases / Q000378:metabolism*; D010179:Pancreas / Q000201:enzymology; D050941:Phosphatidyl-N-Methylethanolamine N-Methyltransferase; D050918:Phosphatidylethanolamine N-Methyltransferase; D012756:Sheep
D008780:Methyltransferases; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; D050918:Phosphatidylethanolamine N-Methyltransferase; D050937:Guanidinoacetate N-Methyltransferase; D050938:Glycine N-Methyltransferase; D050940:Betaine-Homocysteine S-Methyltransferase; D050941:Phosphatidyl-N-Methylethanolamine N-Methyltransferase; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase