title: Liquid chromatographic determination of diazepam in tablets: collaborative study.
abstract: A stability indicating liquid chromatographic method for the determination of diazepam in tablets was collaboratively studied by 6 laboratories. The method uses a C18 reverse phase column, a methanol-water mobile phase, p-tolualdehyde as the internal standard, and photometric detection at 254 nm. The collaborators were supplied with a synthetic tablet powder and 3 commercial tablet samples. The mean recovery of diazepam from the synthetic tablet powder was 100.2%. For all samples analyzed, the coefficient of variation was less than 1.5%. The method has been adopted official first action.
mesh_terms: D002853:Chromatography, Liquid; D003975:Diazepam / Q000032:analysis*; D007202:Indicators and Reagents; D011208:Powders; D013607:Tablets
chemical_list: D007202:Indicators and Reagents; D011208:Powders; D013607:Tablets; D003975:Diazepam