Fibroblast stimulating activity of extracts of hepatic granulomata of Schistosoma mansoni-infected rodents with marked or slight hepatic fibrosis.
Eight weeks following infection with Schistosoma mansoni ICR strain mice showed much more marked hepatic fibrosis than did C57BL/6 mice or hamsters. None the less, extracts of the hepatic granulomata of these animals had similar fibroblast stimulating activity when assayed in vitro.
D000818:Animals; D006224:Cricetinae; D005347:Fibroblasts / Q000378:metabolism; D006099:Granuloma / Q000503:physiopathology*; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000473:pathology*; D008109:Liver Diseases, Parasitic / Q000503:physiopathology*; D008110:Liver Extracts / Q000494:pharmacology*; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000503:physiopathology*; D013936:Thymidine / Q000378:metabolism
D008110:Liver Extracts; D006909:Hydroxyproline; D013936:Thymidine