[Inhibition of various stages of DNA replication in sea urchin embryos].
The embryos of the sea urchin Strongylocentrotus intermedius possess the ability to incorporate into their DNAs 2'-deoxynucleosides together with all their bases, i.e., adenine, guanine, cytosine and thymine. This incorporation is inhibited by 3'-amino-2',3'-dideoxynucleosides with the same bases. 5'-Amino-5'-deoxynucleosides and 5'-amino-2',5'-dideoxynucleosides moderately inhibit the incorporation of [3H]2'-deoxynucleosides into the DNAs by competing with the latter, presumably at the phosphorylation stage. The most potent inhibiting effect is exerted by 2'-amino-2'-deoxynucleosides and 2'-asido-2'-deoxynucleosides; the mechanism of this inhibition is still obscure, however.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects*; D003853:Deoxyribonucleosides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D007700:Kinetics; D010766:Phosphorylation; D012617:Sea Urchins
D003853:Deoxyribonucleosides; D004247:DNA
Ingibirovanie otdel'nykh stadiĭ protsessa replikatsii DNK émbrionov morskikh ezheĭ.