Calmodulin-dependent adenylate cyclase in rat retina and the response to dopamine.
Adenylate cyclase activity from the rat neural retina was highly stimulated with Ca2+ and calmodulin. The retinal adenylate cyclase activity was also increased by dopamine, and the activation was not changed with or without Ca2+-calmodulin in fractions from the neural retina homogenate after sucrose density gradient centrifugation. The results suggest that the two regulation systems (i.e. dopamine and Ca2+-calmodulin) of adenylate cyclase in the rat retina appear to be independent.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002147:Calmodulin / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004789:Enzyme Activation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000201:enzymology*
D002147:Calmodulin; D000262:Adenylyl Cyclases; D002118:Calcium; D004298:Dopamine