Interspecies pharmacokinetic scaling of Sch 34343.
Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body clearance, elimination phase half-life, and mean residence time. This study showed that the extrapolation of animal data to humans on a new investigational drug, Sch 34343, can be potentially useful.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D001835:Body Weight; D004285:Dogs; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D007769:Lactams; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D012453:Saimiri; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D007769:Lactams; C044617:Sch 34343