Calcium accelerates cholesterol phase transitions in analog bile.
Analog bile supersaturated with cholesterol was constituted, filtered and divided into equal portions containing no calcium or calcium, 2.5-15 mM. Aliquots were removed over the next 48 h and filtrates analyzed for cholesterol, bile acid and lecithin. Calcium accelerated cholesterol loss from solution in a dose-related fashion.
D001646:Bile / Q000378:metabolism*; D001647:Bile Acids and Salts / Q000032:analysis; D002118:Calcium / Q000494:pharmacology*; D002784:Cholesterol / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D005374:Filtration; D006801:Humans; D010713:Phosphatidylcholines / Q000032:analysis; D013997:Time Factors
D001647:Bile Acids and Salts; D010713:Phosphatidylcholines; D002784:Cholesterol; D002118:Calcium