Chloroquine-induced hypopigmentation of hair and freckles. Association with congenital renal failure.
Hypopigmentation of hair and freckles occurred in a patient receiving chloroquine sulfate therapy. This patient had a severe congenital renal failure that presumably increased plasma and tissue levels of the drug substantially, accounting for the hypopigmentation.
D000293:Adolescent; D002738:Chloroquine / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006197:Hair / Q000473:pathology; D006200:Hair Color; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000151:congenital / Q000378:metabolism; D008548:Melanosis / Q000473:pathology*; D010859:Pigmentation Disorders / Q000139:chemically induced*
D002738:Chloroquine