Preparation and biokinetic studies of 99mTc-p-butyl-IDA for hepatobiliary scintigraphy.
A freeze-dried powder of tin-p-butyl-IDA to be labelled with 99mTc for hepatobiliary scintigraphy has been developed. Gel chromatography column scanning has been applied for evaluating the labeling efficiency of the complex under different conditions. The results of organ distribution studies in mice and of clinical investigations in human beings showed the stability of the radiopharmaceutical. The preparative 99mTc-p-butyl-IDA concentrates moderately well in the bile with a rapid blood clearance into hepatocytes, very low excretion in the urine and slow clearance into the bile.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging*; D002850:Chromatography, Gel; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007098:Imino Acids / Q000138:chemical synthesis* / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging*; D051379:Mice; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium / Q000138:chemical synthesis* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D007098:Imino Acids; D015609:Organotechnetium Compounds; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; D013667:Technetium