Alterations in CFU-GM growth in preleukaemic and leukaemic AKR/J mice.
The behaviour of committed CFU-GM bone marrow cells was investigated in leukaemic and preleukaemic AKR/J mice. The number of bone marrow CFU-GM decreased in the leukaemic stage of spontaneous AKR/J leukaemia. The addition of AKR/J leukaemic cells inhibited CFU-GM growth from normal target bone marrow. The bone marrow CFU-GM growth was also reduced in late preleukaemic AKR/J mice, whereas no modification in the CFU-GM number in early preleukaemic animals was found.
D000818:Animals; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D007942:Leukemia, Experimental / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D011289:Preleukemia / Q000473:pathology*