[Effect of combined use of adrenocortical hormones and domperidone as anti-emetics during cisplatin therapy].
Eighteen patients received repeated administrations of cisplatin in relatively large amounts (55-75-100 mg/m2) given systemically by drop infusion. As antiemetic treatments, the following were scheduled: on the day before; prednisolone 30mg (3 X p.o.), immediately before; methylprednisolone 500mg (i.v.), and 3 hours after administration of cisplatin ; methylprednisolone 500mg (i.v.) and domperidone 60 mg (suppo.). Domperidone was given twice a day for one week. Nausea, vomiting and anorexia were studied objectively for two weeks. At a dose of 75 mg/m2 of cisplatin, the occurrence and the duration of nausea and vomiting were effectively reduced by the regimen; nausea was observed in 67% of all cases (average duration: 3.3 days) and vomiting was experienced in 40% (1.2 days). Anorexia was observed in 67% of cases and lasted longer (5.2 days). The severity and duration of these side effects of nausea, vomiting and anorexia seemed to appear in a manner related to the dose of cisplatin given, but even at a dose of 100 mg/m2, the regimen described above reduced the patients' discomfort to acceptable levels. No remarkable side effect of this anti-emetic regimen was evident.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D004294:Domperidone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004938:Esophageal Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control; D009369:Neoplasms / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy; D013488:Suppositories; D014839:Vomiting / Q000517:prevention & control
D013488:Suppositories; D004294:Domperidone; D011239:Prednisolone; D002945:Cisplatin; D008775:Methylprednisolone