Glucose turnover in adult non-growing tumour-bearing mice.
[6-3H]glucose was used for measurements of plasma glucose turnover in adult non-growing mice with sarcoma-induced malnutrition. Plasma glucose turnover was increased in freely-fed tumour-bearing mice but not in starved tumour-bearing mice. Elevated glucose turnover in freely-eating sarcoma-bearing mice was associated with an increased glucose pool, the latter not only being due to an expanded distribution volume of glucose. Plasma lactate was elevated in sarcoma-bearing mice independently of their food intake. The results show that elevated plasma glucose turnover in an anorectic tumour-bearing host is not due to insufficient adaptation to food depression. Increased glucose turnover in tumour-bearing mice was associated with an altered intermediary whole body metabolism of glucose which is not entirely accounted for by the state of malnutrition of the host.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D007773:Lactates / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009747:Nutritional Physiological Phenomena; D012513:Sarcoma, Experimental / Q000378:metabolism*; D013217:Starvation / Q000378:metabolism
D001786:Blood Glucose; D007773:Lactates; D005947:Glucose