A human pharmacological study comparing conventional heparin and a low molecular weight heparin fragment.
The pharmacokinetics of a heparin fragment of low molecular weight (LMWH) of 4000-5000 D and unfractioned standard heparin (UFH) have been studied after i.v. injections of different doses and infusions in 8 humans. The heparin activity was significantly higher and the effect on APTT lower after LMWH fragment as compared to UFH in the same doses. The half-life of heparin activity was about 1 hr for UFH and about 2 hr for LMWH. LMWH was found to be eliminated according to first order kinetics and there were no signs of dose dependency.
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D005170:Factor X / Q000037:antagonists & inhibitors; D015951:Factor Xa; D005260:Female; D006207:Half-Life; D006493:Heparin / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D008970:Molecular Weight; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D011516:Prothrombin / Q000378:metabolism
D000990:Antithrombin III; D011516:Prothrombin; D005170:Factor X; D006493:Heparin; D015951:Factor Xa