Effect of imidazole and indomethacin on hemodynamics of the obstructed canine kidney.
In the anesthetized dog renal blood flow (RBF) and its intrarenal distribution were investigated by the radioactive microsphere technique 24 hr after bilateral (BUL) and unilateral (UUL) ureteral ligation. In the control series indomethacin (IM) led to a decrease in RBF with outward shifting of zonal perfusions; imidazole (IA) did not cause significant changes in renal hemodynamics. In the BUL series there was a sharp drop in RBF with a proportional decrease in outer (OC) and inner (IC) cortical perfusion; IM treatment resulted in a further decrease in overall and zonal perfusions. IA, a selective inhibitor of thromboxane synthetase, relieved IC vasoconstriction. In the ligated kidney of the UUL preparations decrease in RBF was due to OC vasoconstriction, while IC perfusion equalled controls. IM led to an overall vasoconstriction in all cortical layers; IA did not influence either total RBF or its distribution. It was concluded that BUL "unmasked" TXA2 production in the IC layers, while IM treatment, by inhibiting the production of PGE2, PGI2, and TXA2, resulted in an overall vasoconstriction both in controls and the BUL and UUL preparations.
D000818:Animals; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply; D008026:Ligation; D008297:Male; D008863:Microspheres; D011868:Radioisotopes; D012079:Renal Circulation / Q000187:drug effects*; D013997:Time Factors; D014513:Ureter / Q000601:surgery; D014517:Ureteral Obstruction / Q000503:physiopathology; D014661:Vasoconstriction; D014664:Vasodilation
D007093:Imidazoles; D011868:Radioisotopes; C029899:imidazole; D007213:Indomethacin