Dystrophic epidermolysis bullosa. A new variant characterized by progressive symmetrical centripetal involvement with scarring.
A patient is reported with a form of epidermolysis bullosa, hitherto undescribed to the best of our knowledge, characterized by the slow centripetal progression of symmetrical blister formation, milia, scarring, atrophy, and nail dystrophy. Electron microscopy, immunofluorescence mapping, and KF-1 monoclonal antibody studies confirm this disease to be a form of dystrophic epidermolysis bullosa, probably of autosomal recessive transmission despite the absence of acral deformities, contractures, mucosal involvement, and growth retardation.
D000911:Antibodies, Monoclonal; D002921:Cicatrix / Q000473:pathology* / Q000503:physiopathology; D004820:Epidermolysis Bullosa / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure
D000911:Antibodies, Monoclonal