Muscle relaxant activity and hypotensive activity of some Tabernaemontana alkaloids.
Stemmadenine, the major alkaloid from the seeds of Tabernaemontana dichotoma, showed hypotensive activity and weak muscle relaxant activity. Perivine, vobasine, coronaridine and dichomine, some of the alkaloids found in the leaves, fruits and bark of T. dichotoma, also showed hypotensive and muscle relaxant activity.
D000109:Acetylcholine / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D003964:Diaphragm / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D026121:Indole Alkaloids; D007211:Indoles; D007928:Lethal Dose 50; D051379:Mice; D009125:Muscle Relaxants, Central; D009388:Neostigmine / Q000494:pharmacology; D009466:Neuromuscular Blocking Agents; D010791:Phrenic Nerve / Q000187:drug effects; D051381:Rats
D000470:Alkaloids; D000959:Antihypertensive Agents; D026121:Indole Alkaloids; D007211:Indoles; D009125:Muscle Relaxants, Central; D009466:Neuromuscular Blocking Agents; C046117:stemmadenine; D009388:Neostigmine; D000109:Acetylcholine