title: [Analysis of 99mTc-HIDA kinetics using an adaptive model].
abstract: The paper is concerned with the results of assaying hepatocyte function on the basis of an adaptive pharmacokinetic model worked out by the authors. Hepatoscintigraphy with 99mTc-HIDA was used in 3 phases: the vascular phase of RP transport (the 1st min of investigation, scintigrams with a 2 s interval), the parenchymatous phase (with a 20 s interval in subsequent 10 min), the biliary phase (with a 3 min interval). The hepatocytic phase of 99mTc-HIDA transport was evaluated on the basis of the adaptive 5-compartmental model calculating the value of transport constants. In terms of differential diagnosis, the intercompartmental constants K1,2 (blood-liver) and K2,1 (liver-blood) turned out to be the most informative. Thus the assaying of hepatocyte transport function using the proposed adaptive model helps to define the degree of liver involvement in a pathological process, to choose the therapeutic tactics and method, to evaluate its efficacy and to predict possible complications.
mesh_terms: D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging*; D001692:Biological Transport; D003937:Diagnosis, Differential; D006801:Humans; D007098:Imino Acids / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008954:Models, Biological; D011877:Radionuclide Imaging; D013667:Technetium / Q000097:blood / Q000378:metabolism; D019780:Technetium Tc 99m Lidofenin
chemical_list: D007098:Imino Acids; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium
vernacular_title: Analiz kinetiki 99mTc-HIDA s pomoshch'iu adaptivnoĭ modeli.