title: What's new in Osmosin and intestinal perforation?
abstract: New formulations of drugs may have unexpected side effects. Osmosin is a new osmotic-pump controlled-release formulation of Indomethacin, designed to prevent gastrointestinal irritation. However, in a small number of cases the use of Osmosin has coincided with perforation of the small and large intestine, probably because passage of the tablet through the gastrointestinal tract was impeded.
mesh_terms: D000368:Aged; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced / Q000473:pathology; D007082:Ileum / Q000473:pathology; D007213:Indomethacin / Q000009:adverse effects*; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000473:pathology; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology
chemical_list: D007213:Indomethacin