title: Angiotensin II enhances calcium exchanges in isolated rat aorta.
abstract: The effect of angiotensin II (AII) on calcium exchanges in isolated rat aorta was investigated using the 45Ca lanthanum technique. AII induced a rapid (10 s) and long-lasting (120 min) increase of calcium uptake and enhanced calcium release for a short period. AII-stimulated calcium uptake was antagonized by saralasin and verapamil but not by indomethacin. These data indicate that AII increases rat aortic calcium exchanges via receptor-operated and voltage-dependent calcium channels.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000804:Angiotensin II; D014700:Verapamil; D012504:Saralasin; D002118:Calcium; D007213:Indomethacin