Comparative pharmacokinetics of febantel and its metabolites in sheep and cattle.
The pharmacokinetics of febantel and its main metabolites were studied in cattle and sheep. Seven ewes and 4 heifers were given febantel orally in a single dose of 7.5 mg/kg, 25 mg/kg, or 45 mg/kg of body weight. Plasma concentrations vs time of febantel and individual metabolites were determined by high-performance liquid chromatography analysis. Intestinal absorption of febantel was faster and biotransformations were more active in sheep than in cattle.
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000097:blood / Q000378:metabolism*; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D005260:Female; D005273:Fenbendazole / Q000097:blood / Q000378:metabolism*; D006146:Guanidines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*
D000871:Anthelmintics; D001562:Benzimidazoles; D006146:Guanidines; D005273:Fenbendazole; C011030:oxfendazole; C017309:febantel