Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol.
Potential carcinogenicity and promoting effects of sodium o-phenylphenate (OPP-Na) in two-stage urinary bladder carcinogenesis were shown in male F344 rats pretreated with 0.01% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). However, o-phenylphenol (OPP) did not enhance the occurrence of urinary bladder lesions in rats pretreated with BBN. Scanning electron microscopy of OPP-Na-treated animals demonstrated a dose-dependent production of pleomorphic microvilli on the luminal surface of bladder superficial cells, whereas these were not observed with OPP. These results give some support to the conclusion that OPP-Na may be carcinogenic in the urinary bladder of male rats.
D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D001835:Body Weight; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity; D002273:Carcinogens; D003043:Cocarcinogenesis; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000648:ultrastructure; D009929:Organ Size; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D001713:Biphenyl Compounds; D002273:Carcinogens; D002085:Butylhydroxybutylnitrosamine; C004369:2-phenylphenol