Extramedullary hematopoiesis. A cause of severe generalized lymphadenopathy in agnogenic myeloid metaplasia.
Although microscopic evidence of extramedullary hematopoiesis in lymph nodes is a frequent finding in autopsy studies of patients with agnogenic myeloid metaplasia, clinically significant lymphadenopathy is a rare occurrence. In this article we describe an unusual case of severe generalized lymphadenopathy and lymphedema secondary to extramedullary hematopoiesis in multiple lymph nodes. With the use of low-dose radiotherapy, both the lymphadenopathy and lymphedema resolved.
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D006410:Hematopoiesis; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000503:physiopathology / Q000532:radiotherapy; D008198:Lymph Nodes / Q000473:pathology; D008209:Lymphedema / Q000150:complications / Q000532:radiotherapy; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000503:physiopathology / Q000532:radiotherapy; D013156:Splenectomy