Idiopathic combined immunocytopenia.
Four patients with combined immunocytopenia of unknown origin were investigated. Two patients with pancytopenia had allo- and autoantibodies against erythrocytes, granulocytes and thrombocytes. Two other patients with granulocytopenia and thrombocytopenia showed allo- and autoantibodies against granulocytes and thrombocytes. All patients went into a transient or persistent remission under immunosuppressive therapy. The normalization of peripheral blood correlated with the disappearance of antibodies suggesting that the cytopenia was caused by an antibody mediated autoimmune mechanism.
D000328:Adult; D000380:Agranulocytosis / Q000188:drug therapy / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000188:drug therapy / Q000276:immunology*; D013921:Thrombocytopenia / Q000188:drug therapy / Q000276:immunology*
D001323:Autoantibodies; D007166:Immunosuppressive Agents