Energy difference associated with proline isomerization in ribonuclease A.
We examined energy differences caused by the cis-trans transformation of every proline residues in the native structure of RNAase A. The results show that the cis form of Pro-93 and Pro-114 gave the lowest conformational energy, i.e., conformations after conversion of one of the proline residues to the trans form had a little higher energy; the transformation of Pro-42 and Pro-117 to the cis form, on the other hand, caused a much higher energy increase.
D007536:Isomerism; D011392:Proline; D011487:Protein Conformation; D012259:Ribonuclease, Pancreatic
D011392:Proline; D012259:Ribonuclease, Pancreatic