title: [Experimental multifactorial study of the effect of doxycycline and glucosaminylmuramyl dipeptide on the primary immunologic response to antigens of a tularemia vaccine strain].
abstract: The effect of the combined use of doxycycline and glucosaminylmuramyl dipeptide (GMDP) on the primary immune response to antigens of tularemia vaccine was studied on CBA male mice with the use of the multifactorial design of experiment. Antibodies to the blood serum of the immunized animals were determined by the passive hemagglutination test with the use of the tularemia antigen diagnosticum. The delayed type hypersensitivity was estimated by changes in the weight of the extremities of the experimental and control animals treated with the antigen and saline solution, respectively. The multifactorial experiments provided precise quantitative characteristics of the optimal dose-time schedule for the combined use of GMDP and doxycycline.
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D004318:Doxycycline / Q000494:pharmacology*; D005604:Francisella tularensis / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012107:Research Design
chemical_list: D000942:Antigens, Bacterial; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C023868:N-acetyl-beta-glucosaminyl-N-acetylmuramyl-alanylisoglutamine; D004318:Doxycycline
vernacular_title: Eksperimental'noe mnogofaktornoe izuchenie vliianiia doksitsiklina i gliukozaminilmuramildipeptida na pervichnĭ immunologicheskiĭ otvet k antigenam vaktsinnogo shtamma tuliaremii.