[Positive modification of hemodynamics in post cardiac surgery patients by hemofiltration. Improved method for the demonstration of myocardial depressant factor (MDF) in hemofiltrate].
The method of haemofiltration was used in 29 postoperative cardio-surgical patients with low blood pressure, high left ventricular filling pressure and low total peripheral resistance, which did not respond to the use of the intraaortic balloon pump or pharmaco-therapy. In severe low-output syndrome hemodynamic parameters are: reduced mean arterial pressure, increased left ventricular filling pressure, increased mean arterial pulmonary pressure as well as significantly reduced total peripheral resistance [4-6, 28]. Inspite of pharmaco-therapy, cardiac performance regarding peripheral perfusion is insufficient; this leads to a vicious cycle of irreversible O2-debt and severe cellular damage. After haemofiltration there was a significant improvement in the haemodynamic parameters, which in our opinion was due to the elimination of toxic peptides such as Myocardial Depressant Factor (MDF). In 27 of a total of 29 patients, haemodynamic parameters returned to normal after treatment. 19 patients were discharged, eight patients died after a number of days or weeks from causes not related to the original cardiogenic shock (cerebral embolism, reinfarction, myocardiopathy and pneumonia).
D000328:Adult; D000368:Aged; D000818:Animals; D001769:Blood; D001794:Blood Pressure; D005260:Female; D006168:Guinea Pigs; D006331:Heart Diseases / Q000601:surgery*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009201:Myocardial Depressant Factor / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011183:Postoperative Complications / Q000628:therapy; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D014462:Ultrafiltration; D014655:Vascular Resistance
D009201:Myocardial Depressant Factor; D010455:Peptides
Positive Beeinflussung der Hämodynamik bei postkardiochirurgischen Patienten durch die Hämofiltration. Eine verbesserte Methodik zur Darstellung des Myocardial Depressant Factor's (MDF) in Hämofiltrat.