Immunoreactive parathyroid hormone is present in subretinal fluids of the human eye.
(44-68) human Parathyroid hormone (hPTH) was studied in subretinal fluids (SRF) of 20 human eyes with rhegmatogenous retinal detachments. A (44-68) hPTH carboxyl mid-regional radioimmunoassay was used. Depending on the extent and the duration of the retinal detachments, (44-68) hPTH ranged between normal serum levels (ca. 100-300 pg/ml) up to excessive amounts of 4000 pg/ml with longstanding disease and proliferative vitreoretinopathy. Aqueous humors (AH) of one patient with bilateral iridocyclitis and complicated cataract ranged at 90-132 pg/ml (44-68) hPTH, whereas a control population undergoing surgery for senile cataracts had no detectable (44-68) hPTH in AH. The AH of one diseased eye of heterochromia complicata Fuchs showed excessive amounts of more than 4000 pg/ml (44-68) hPTH.
D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D005128:Eye Diseases / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000378:metabolism*; D011863:Radioimmunoassay; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012164:Retinal Diseases / Q000378:metabolism / Q000473:pathology; D013223:Statistics as Topic; D013997:Time Factors; D014606:Uveitis, Anterior / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D014822:Vitreous Body
D010281:Parathyroid Hormone