Severe hypertension during anaesthesia for dacryocystorhinostomy.
A healthy 82-year-old woman presented for dacryocystorhinostomy under general anaesthesia. Following the application of intranasal cocaine and subcutaneous injection of felypressin she developed severe hypertension, multiple ventricular ectopic beats and depression of the ST segment on the electrocardiogram. A drug interaction is suspected.
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003042:Cocaine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology; D004347:Drug Interactions; D005259:Felypressin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000209:etiology; D007765:Lacrimal Apparatus / Q000601:surgery; D008236:Lypressin / Q000009:adverse effects*; D009296:Nasal Cavity
D008236:Lypressin; D005259:Felypressin; D003042:Cocaine