Effects of general and local anesthesia on the pharmacokinetics of cefazolin in patients undergoing orthopedic surgery.
The pharmacokinetics of cefazolin in patients undergoing orthopedic surgery with either general (enflurane) or local (lidocaine or marcaine) anesthesia were studied. No differences in either mean serum levels at 30, 60, or 120 min after the intravenous injection of cefazolin or serum half-lives were seen between the two groups of patients.
D000328:Adult; D000768:Anesthesia, General; D000772:Anesthesia, Local; D001842:Bone and Bones / Q000601:surgery*; D002437:Cefazolin / Q000378:metabolism* / Q000627:therapeutic use; D004737:Enflurane; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008012:Lidocaine; D008297:Male; D011292:Premedication
D004737:Enflurane; D008012:Lidocaine; D002437:Cefazolin