title: Action and localization of glycine and taurine in the cat retina.
abstract: The effects on retinal ganglion cells of iontophoretically applied glycine, taurine and strychnine were studied in the optically intact eye of the cat. Glycine and taurine suppressed the light-evoked discharge of all on-centre and off-centre brisk ganglion cells, regardless of the visual stimulus used. Strychnine blocked the action of externally applied glycine and taurine. The light-evoked response of all ganglion cells was raised by strychnine. The tonic discharge of the light response was suppressed or raised by the drugs more than the phasic response. A population of amacrine cells, which was heavily labelled by [3H]glycine, did not take up [3H]taurine. [3H]taurine was only weakly accumulated by inner nuclear layer neurones and was predominantly located in the outer retina.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001345:Autoradiography; D002415:Cats; D005998:Glycine / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D010775:Photic Stimulation; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology; D013654:Taurine / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D013654:Taurine; D013331:Strychnine; D005998:Glycine