[Pneumopathies caused by hypersensitivity to amiodarone and associated nephropathies. Study by alveolar lavage].
Four cases of amiodarone-induced restrictive, hypoxaemic lung disease are described. The cumulative dosages of amiodarone were relatively low (30 to 100 g). Alveolar lavage studies showed a lymphocytosis and study of the lymphocytic sub-populations showed an increase in the OKT8 group, and an inversion of the OKT4/OKT8 ratio. The outcome was favourable on withdrawal of amiodarone and steroid therapy. The immunological origin of this form of lung disease was confirmed. Two patients had renal failure; in the first case, hypercalcaemia, hyperphosphoremia and renal calcification were observed. The second patient had endo- and extracapillary glomerulonephritis with C3 deposits and circulating immune complexes. Renal failure regressed in both cases on withdrawal of amiodarone and with steroid therapy.
D058186:Acute Kidney Injury / Q000139:chemically induced; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D007507:Therapeutic Irrigation
D001572:Benzofurans; D000638:Amiodarone
Pneumopathies d'hypersensibilité à l'amiodarone et néphropathies associées. Etude par lavage alvéolaire.