title: [Improvement of the solubility of problem drugs. 1. Production of iomeglamic acid fused and solidified products].
abstract: The insoluble X-ray diagnostic iomeglamic acid could be converted to a more soluble modification by melting and solidifying it in liquid nitrogen. The amorphous state is proved by X-ray diffraction and differential thermal analysis. During storage, recristallisation of the product appears. By means of the proved amorphous state, it seems possible to determine the amount of the amorphous state, which makes the drug more soluble from solid dispersions.
mesh_terms: D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D003460:Crystallization; D004055:Differential Thermal Analysis; D007462:Iodobenzenes / Q000138:chemical synthesis*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D007462:Iodobenzenes; C002060:iomeglamic acid
vernacular_title: Beiträge zur Verbesserung des Auflösungsverhaltens von Problemarzneistoffen. 1. Mitteilung: Herstellung eines lomeglamsäure-Schmelzerstarrungsproduktes.