title: Failure of oral zinc therapy to alleviate Bacteroides nodosus infections in cattle and sheep.
abstract: Cattle and sheep with Bacteroides nodosus infection were treated orally with both high (65 mg Zn/kg and 82 mg Zn/kg) and low (1 mg Zn/kg and 8.6 mg Zn/kg) doses of zinc sulphate respectively. The lower dose rates administered weekly for one month, in the case of cattle, or daily for 2 weeks, in the case of sheep, had no effect either on serum zinc levels or the prevalence or severity of infection in treated animals. High dose rates of zinc (approximately 2.5 g Zn per head per day) were required to elevate serum levels above those normally present in both cattle and sheep. Even these dose rates continued daily for about 2 weeks had no beneficial effect on B. nodosus infection in either species.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013431:Sulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D019287:Zinc Sulfate
chemical_list: D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc