[Platelet monoamine oxidase and sex hormones in a population of depressed patients].
The association between changes in platelet MAO activity and Major Depressive Episode have been demonstrated. Cyclical changes in sex hormones serum levels had never been related with changes of MAO activity in depressed patients. Platelet MAO activity, oestrogen serum levels, progesterone serum levels and testosterone serum levels, have been measured in drug free depressed patients: 22 men and 42 women. This study demonstrates no relationship between serum levels hormons and platelet MAO activity, measured in men and in women. If young women are separated from menopaused women, platelet MAO activity is negatively correlated with oestrogen serum levels, in non menopaused women. Significance of this variation in studies about the use of MAO as a biochemical marker in depression is discussed.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D003866:Depressive Disorder / Q000097:blood*; D004967:Estrogens / Q000097:blood; D005260:Female; D014644:Genetic Variation; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008593:Menopause; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D008995:Monoamine Oxidase
Monoamine oxydase plaquettaire et hormones sexuelles dans une population de déprimés.