IgA anti-endomysial antibody detection in the serum of patients with dermatitis herpetiformis following gluten challenge.
This study reports the appearance of IgA-class anti-endomysial antibodies in the serum of 8 out of 12 patients with dermatitis herpetiformis who were challenged with gluten after a number of years of control of the rash with a strict gluten-free diet. Although there was no evidence for the antibodies having any pathogenic role in the rash of dermatitis herpetiformis, their presence may be related to the deterioration in the gluten-sensitive enteropathy.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002446:Celiac Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D003874:Dermatitis Herpetiformis / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D005983:Glutens / Q000009:adverse effects; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology*
D001323:Autoantibodies; D007070:Immunoglobulin A; D005983:Glutens