Drug induced hypothermia in adult and senescent rats.
Temperature regulation was evaluated in senescent (34-40 month old) and adult (8-9 month old) female Iva:WIWU and Emd:Wi-AF/Han rats. Injection of 1.5 mg/kg BW apomorphine HCl or 1.0 mg/kg BW oxotremorine sesquifumarate produced comparable maximal hypothermic responses in adult and senescent rats. However, the latency to reach maximal hypothermia after oxotremorine (but not apomorphine) was longer in senescent than in adult rats of both strains.
D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D007035:Hypothermia / Q000139:chemically induced*; D010095:Oxotremorine / Q000494:pharmacology; D051381:Rats / Q000235:genetics / Q000502:physiology*; D011919:Rats, Inbred Strains / Q000502:physiology; D011930:Reaction Time
D010095:Oxotremorine; D001058:Apomorphine