Antimycin A- and hydroxamate-insensitive respiration in yeasts.
In this paper evidence is presented for the mitochondrial localization of the antimycin A (AA) + salicylhydroxamate (SHAM)-insensitive respiration of the yeasts Kluyveromyces lactis, Endomycopsis capsularis and Hansenula saturnus. Such a respiration, which can be sustained by NADH and NADPH but not by succinate, is inhibited by high concentrations of azide. AA + SHAM-insensitive respiration is not phosphorylating and its postulated physiological role is to oxidize NADH.
D000935:Antifungal Agents / Q000494:pharmacology*; D000968:Antimycin A / Q000494:pharmacology*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D010843:Pichia / Q000187:drug effects / Q000378:metabolism; D004718:Saccharomycetales / Q000187:drug effects / Q000378:metabolism; D012457:Salicylamides / Q000494:pharmacology*; D013386:Succinates / Q000378:metabolism; D015003:Yeasts / Q000187:drug effects / Q000378:metabolism*
D000935:Antifungal Agents; D012457:Salicylamides; D013386:Succinates; D009243:NAD; D009249:NADP; D000968:Antimycin A; C005703:salicylhydroxamic acid