title: [Kinetics of the cell population in adenocarcinoma 755 after cyclophosphane administration and rate of tumor growth after an additional course of therapy with cyclophosphane and 6-mercaptopurine].
abstract: The two injections of cyclophosphane (100 mg/kg) to mice with adenocarcinoma 755 on the 6th and 11th days after tumour transplantation had no influence on the cell cycle but induced a decrease of its growth rate due to an increase in the level of cell losses. The third cyclophosphane injection (the same dose) on the 17th day after the tumour transplantation or an additional course of five 6-mercaptopurine injections (50 mg/kg each dose) did not change essentially the growth rate of tumours.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D015122:Mercaptopurine / Q000627:therapeutic use*; D051379:Mice; D009368:Neoplasm Transplantation
chemical_list: D003520:Cyclophosphamide; D015122:Mercaptopurine
vernacular_title: Kinetika kletochnoĭ populiatsii adenokartsinoma 755 posle vvedeniia tsiklofosfana i skorost' rosta opukholi posle povtornogo kursa terapii tsiklofosfanom i 6-merkaptopurinom.