title: The effect of cholecystectomy on bile reflux. An experimental study.
abstract: In an experimental study the effect of cholecystectomy on bile reflux into the stomach was investigated. Five dogs were used and a large number of bile reflux measurements carried out (115 tests). During each test, reflux was measured over a continuous period of 6 hours by estimating the concentration of bile phospholipids (lecithin and lysolecithin) in the gastric juice. The pre-cholecystectomy phospholipid concentration in the stomach was 7,751 +/- 1,621 mg/dl (mean +/- SEM) and the post-cholecystectomy concentration 35,181 +/- 10,653 mg/dl (P less than 0,05). Two dogs developed gastric mucosal changes, mainly foveolar hyperplasia. The importance of measuring reflux repeatedly over long periods of time in order to get a more representative picture of reflux is stressed.
mesh_terms: D000818:Animals; D001655:Bile Reflux / Q000209:etiology*; D001660:Biliary Tract Diseases / Q000209:etiology*; D002763:Cholecystectomy / Q000009:adverse effects*; D004285:Dogs; D005750:Gastric Juice / Q000032:analysis; D005753:Gastric Mucosa / Q000473:pathology; D006965:Hyperplasia; D008244:Lysophosphatidylcholines / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis
chemical_list: D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines