Resolution of acromegaly, amenorrhea-galactorrhea syndrome, and hypergastrinemia after resection of jejunal carcinoid.
A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia. In addition, she had hypergastrinemia with abnormal secretory dynamics and evidence of a large pituitary tumor with suprasellar extension and erosion of the floor of the sella turcica. Evaluation of secretory diarrhea revealed a large abdominal tumor, which on removal was found to be a carcinoid of the jejunum. Postoperatively, the acromegaly, amenorrhea-galactorrhea, and hypergastrinemia resolved, and the pituitary returned to normal size, with regrowth of the sella floor. The carcinoid tumor was shown by immunoperoxidase staining to contain GH-releasing hormone.
D000172:Acromegaly / Q000628:therapy*; D000328:Adult; D000568:Amenorrhea / Q000628:therapy*; D002276:Carcinoid Tumor / Q000601:surgery*; D003967:Diarrhea / Q000628:therapy; D005260:Female; D005687:Galactorrhea / Q000628:therapy*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007580:Jejunal Neoplasms / Q000601:surgery*; D007775:Lactation Disorders / Q000628:therapy*; D009384:Paraneoplastic Endocrine Syndromes / Q000628:therapy*; D010902:Pituitary Gland / Q000000981:diagnostic imaging; D011247:Pregnancy; D014057:Tomography, X-Ray Computed
D005755:Gastrins