title: CIGMA assessment of insulin resistance and pancreatic beta cell function in the elderly.
abstract: Ten elderly subjects aged 71-85 years and with no indication of diabetes had an oral glucose tolerance test (OGTT) and a one hour's continuous infusion of glucose with model assessment (CIGMA) to assess the pathophysiology of glucose intolerance. All had fasting plasma glucose less than 6 mmol/l and glycosylated haemoglobin levels less than 8.8%, but seven had impaired glucose tolerance during the OGTT. The CIGMA similarly assessed glucose tolerance (rs = 0.65, P less than 0.02), and in addition showed increased insulin resistance and low normal beta cell function.
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male
chemical_list: D001786:Blood Glucose