[Activation of lipid peroxides in the liver during hypokinesia and its prevention by antioxidants].
Experiments on white rats showed that exposure to hypokinesia increased peroxidation of unsaturated fatty acids of lipids of cell membranes, decreased the content of sulfhydryl groups, and increased the content of disulphide groups. This was very marked during the first 4-7 days, i.e., during the time of a distinct stress-reaction. At later stages the rate of free radical processes decreased slightly. In the recovery period that followed 7-day hypokinesia lipid peroxidation in the rats gradually returned to normal. The initiation of free radical reactions during hypokinesia can be prevented by means of antioxidants (acetate tocopherol, sodium selenite) and syrepar.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D008110:Liver Extracts / Q000494:pharmacology; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D064586:Selenic Acid; D012643:Selenium / Q000494:pharmacology; D018036:Selenium Compounds; D013315:Stress, Psychological / Q000378:metabolism*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D008054:Lipid Peroxides; D008110:Liver Extracts; D018036:Selenium Compounds; C014814:sirepar; D014810:Vitamin E; D024502:alpha-Tocopherol; D012643:Selenium; D064586:Selenic Acid; D024505:Tocopherols
Aktivatsiia perekisnogo okisleniia lipidov v pecheni pri gipokinezii i preduprezhdenie ee antioksidantami.