Synthesis and some characteristics of no-carrier added [18F]fluorotrimethylsilane.
[18F]Fluorotrimethylsilane was prepared in 80% decay corrected yield by reaction of no-carrier added tetramethyl-ammonium fluoride (hydroxide as bulk anion) with chlorotrimethylsilane in 65% aqueous acetonitrile. The 18F gas was collected in a cold-trap at -130 degrees C and found to have an Ostwald solubility coefficient of 11.5 in paraffin oil. Accurate measurement of its aqueous solubility was precluded by hydrolysis. When rats were allowed to inhale [18F]fluorotrimethylsilane extensive uptake of 18F occurred in bone, demonstrating ready release of fluoride in vivo.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005461:Fluorine; D007553:Isotope Labeling / Q000379:methods; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012825:Silicon; D014018:Tissue Distribution; D014297:Trimethylsilyl Compounds / Q000378:metabolism
D011868:Radioisotopes; D014297:Trimethylsilyl Compounds; D005461:Fluorine; C038077:trimethylfluorosilane; D012825:Silicon