title: Plasma oxytocin concentrations in man after different routes of administration of synthetic oxytocin.
abstract: Plasma oxytocin was determined by RIA in three male subjects under basal conditions and following administration of synthetic oxytocin. As compared to basal levels (below 10 pg/ml), plasma oxytocin was found to be elevated markedly (36 to 85 pg/ml) in response to application by nasal spray (total dose: 65 to 100 micrograms). Intramuscular injection (25 micrograms) resulted in very high oxytocin levels (360 to 480 pg/ml), whereas buccal administration (70 micrograms) was proved to be ineffective (levels below 10 pg/ml plasma). In each case, plasma vasopressin remained unchanged.
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002610:Cheek; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage* / Q000097:blood; D011863:Radioimmunoassay; D014667:Vasopressins / Q000097:blood
chemical_list: D014667:Vasopressins; D010121:Oxytocin