Baclofen prolongs the analgesic effect of fentanyl in man.
Pretreatment with baclofen prolonged the duration of fentanyl-induced analgesia from 18 to 30 min in patients undergoing neurosurgical anaesthesia (fentanyl plus nitrous oxide in oxygen). This observation is consistent with a potentiating effect of GABA on opioid analgesia.
D000328:Adult; D000768:Anesthesia, General; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D007016:Hypophysectomy; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D011229:Preanesthetic Medication
D001418:Baclofen; D009609:Nitrous Oxide; D005283:Fentanyl