Antifertility efficacy of Catharanthus roseus Linn: a biochemical and histological study.
Oral administration of Catharanthus roseus Linn, leaf extract caused widespread testicular necrosis, hyalinization of tubules and Sertoli cell-only-Syndrome. Biochemical studies revealing notable reduction in glycogen and fructose levels in reproductive tissues support the histological observations and confirm the antifertility properties of C. roseus extract.
D000818:Animals; D030008:Catharanthus; D005298:Fertility / Q000187:drug effects; D005632:Fructose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D014649:Vas Deferens / Q000187:drug effects* / Q000473:pathology
C046419:Catharanthus roseus extract; D010936:Plant Extracts; D005632:Fructose; D006003:Glycogen