[Changes in water metabolism in rats under the influence of naloxone: role of vasopressin].
The effect of naloxone (0.6 mg; 1.2 mg; 2.4 mg X kg-1) were compared in normal Long Evans (N) and Brattleboro (D.I.) conscious rats. Naloxone did not change the values of drinking, diuresis, food intake, blood pressure, Na+ and K+ urinary excretion measured during 24 hours. During the two hours following drug injection, naloxone (1.2 and 2.4 mg X kg-1) reduced diuresis in normal as well as in D.I. rats. Water drinking was only modified in D.I. rats: this effect was shown to be a consequence of antidiuresis. These results suggest that the antidiuretic properties of naloxone are independent of vasopressin secretion. They do not support in a role of opiate receptors on vasopressin secretion in normal hydrated animals.
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D003919:Diabetes Insipidus / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects; D004326:Drinking; D004435:Eating; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000502:physiology*
D014667:Vasopressins; D009270:Naloxone
Modifications du métabolisme hydrique du rat sous l'influence de la naloxone: role de la vasopressine.