[Ultrastructure of fat cells of obese patients with diabetes mellitus before and after treatment with a reducing diet].
Ultrastructural investigation of lipocytes of obese diabetics (Diabetes mellitus) before and after treatment with a reducing diet 21 diabetics not depending on insulin with obesity of the second or third degree were given for 3 months a reducing diet containing 5110 kJ/day (86 g protein, 41 g fat, 119 g carbohydrates). After treatment the test persons had a loss of weight of 7.60 kg on average. Before and after treatment subcutaneous adipose tissue was taken by puncture biopsy and investigated by electron microscopy. After treatment extended intercellular spaces are evident in which collagenic and elastic fibres appear quantitatively enlarged. A certain plication and inequality of the cell membranes, a penetration of the fat droplet by cytoplasmatic outgrowths as well as a diminution of the lipocytes and the big fat droplet were found. The investigations show that even the relatively short treatment of 3 months exercises an influence on the structure of the lipocytes. That shows new possibilities of therapy and prophylaxis of obesity.
D000273:Adipose Tissue / Q000648:ultrastructure*; D002462:Cell Membrane / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D003920:Diabetes Mellitus / Q000178:diet therapy / Q000473:pathology*; D004038:Diet, Reducing; D006801:Humans; D008854:Microscopy, Electron; D009765:Obesity
Ultrastrukturelle Untersuchungen der Fettzellen Adipöser mit Diabetes mellitus vor und nach Behandlung mit Reduktionskost.