Antithrombin III concentrates for treatment of disseminated intravascular coagulation in children.
Six children (1 month to 5 years old) with DIC were treated with bolus injection of AT-III concentrates and/or continuous heparin infusion. In one case, when AT-III concentrates were administered without heparin, the platelet count was normalized in accordance with a rise in the plasma AT-III level. In the other children, who were treated with both AT-III concentrates and heparin, most of the abnormalities in coagulation studies were normalized within 5 days in four of five cases. These findings suggest that the administration of AT-III concentrates may significantly enhance the therapeutic efficacy of heparin, and that the use of AT-III concentrates with heparin is a safe and effective regimen for the treatment of childhood DIC.
D000990:Antithrombin III / Q000032:analysis / Q000627:therapeutic use*; D001777:Blood Coagulation; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
D000990:Antithrombin III