Pharmacokinetics and pharmacodynamics of three sustained-release theophylline preparations (Theograd, 350 mg Theolair Retard, and 300 mg Theolin Retard) in steady state in six normals and six patients with chronic asthmatic bronchitis--Part II: Lung function.
The lung function profiles of a group of six healthy volunteers and six patients with moderately severe asthmatic bronchitis were compared after one theophylline infusion and after oral administration of Theograd (350 mg), Theolair Retard (350 mg), and Theolin Retard (300 mg) all given twice daily for 1 week. The group of patients showed a good reversibility of bronchoconstriction after intravenous theophylline administration; however, only minor improvement was observed at the levels reached after relatively low oral doses.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D001991:Bronchitis / Q000188:drug therapy / Q000378:metabolism*; D003692:Delayed-Action Preparations; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D014797:Vital Capacity
D003692:Delayed-Action Preparations; D013806:Theophylline