Increased activity of creatine kinase isoenzyme MB in a theophylline-intoxicated patient.
A 78-year-old woman had increased activities of creatine kinase (CK; EC 2.7.3.2) and CK-MB isoenzyme in her serum, associated with severe theophylline intoxication. The time course for CK-MB activity was similar to that from an acute myocardial infarction. Clinical findings, however, including electrocardiograms, did not support the diagnosis of myocardial infarction. We suggest caution in interpreting CK-MB results in severe theophylline intoxication.
D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D009203:Myocardial Infarction / Q000175:diagnosis; D013806:Theophylline / Q000506:poisoning* / Q000627:therapeutic use
D007527:Isoenzymes; D013806:Theophylline; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase