Antitumor activity of sarcolysin containing crosslinked copolymers in mice.
Some years ago it was found that the binding of sarcolysin to the copolymer of vinylpyrrolidone and maleic anhydride results in changes of some its pharmacological properties including toxicity, antitumor activity and immune suppression. In an attempt to keep some of this qualities of the polymeric derivatives of sarcolysin and to develop a depot-effect, sarcolysin was bonded to space linked insoluble copolymers. Studies carried out on the antitumor action in 6 transplantable tumors (L1210, P388, EAT, NK/Ly, LLC and Sarcoma 180) are discussed.
D000818:Animals; D008558:Melphalan / Q000031:analogs & derivatives / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011108:Polymers / Q000494:pharmacology*
D011108:Polymers; D008558:Melphalan