Autoimmune hemolytic anemia with concurrence of warm and cold red cell autoantibodies and a warm hemolysin.
This report describes the laboratory findings and clinical course of a patient with thrombophlebitis, venous gangrene, and autoimmune hemolytic anemia. Three concomitant red cell autoantibody activities were detected: a low-titer, high-thermal-amplitude, IgM anti-I cold agglutinin; an IgG warm 'incomplete' panagglutinating autoantibody; and an IgM warm hemolysin.
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D003080:Cold Temperature; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology*; D006460:Hemolysin Proteins / Q000032:analysis; D006358:Hot Temperature; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D006460:Hemolysin Proteins; D007075:Immunoglobulin M