title: Anthelmintic efficacy of febantel combined with praziquantel in dogs.
abstract: Ninety-four dogs were randomly assigned to 1 of 6 groups (5 treated and 1 untreated control) for evaluation of anthelmintic efficacy. Three anthelmintic formulations were studied: a febantel paste, a praziquantel paste, and a combination paste containing both active ingredients. Treated dogs were dosed once daily for 3 days. The minimal effective dosages in combination were established as 10 mg of febantel and 1 mg of praziquantel/kg of body weight. At those dosages for the combination, 99.5% to 100% of the major nematodes and cestodes identified (ie, Ancylostoma caninum, Trichuris vulpis, Toxocara canis, Dipylidium caninum, and Taenia pisiformis) were eliminated. Febantel paste (10 mg/kg) alone was ineffective against cestodes (14.2% elimination of Dipylidium caninum) and praziquantel paste (1 mg/kg) alone was ineffective (0% to 2.4% elimination) against nematodes.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011223:Praziquantel / Q000627:therapeutic use*
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D006146:Guanidines; D007546:Isoquinolines; C040536:febantel-praziquantel paste; D011223:Praziquantel; C017309:febantel