Systemic response to local urate crystal induced inflammation in man: a possible model to study the acute phase response.
The production of a systemic inflammatory response to intradermal monosodium urate crystal injection is described. A transient, self-limiting local response is associated with a systemic response detectable by a rise in the white cell count and serum amyloid A protein. The white cell change parallels the evolution of the local response, whereas the serum amyloid A response lags behind the local lesion, peaking after the local lesion is resolving. Intradermal monosodium urate injection is proposed as a possible inflammatory stimulus to explore the acute phase protein response in different disease states.
D000208:Acute Disease; D000328:Adult; D003460:Crystallization; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D007958:Leukocyte Count; D008297:Male; D008954:Models, Biological; D000685:Serum Amyloid A Protein / Q000032:analysis; D014527:Uric Acid
D000685:Serum Amyloid A Protein; D014527:Uric Acid