The octanol/water distribution of mercury compounds.
Lipophilicity plays an important role in the biological action of mercurials. The distribution of one inorganic and five organic mercury compounds was determined in an n-octanol/water system. Lipophilicity decreased in the order CH3HgCl, bromomercurihydroxypropane, HgCl2, chlormerodrin, p-chloromercuribenzoic acid (PCMB), p-chloromercuriphenylsulfonic acid (PCMBS). The toxicity of mercurials, as reported in the literature, appears to parallel their lipophilicity.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008628:Mercury / Q000032:analysis*; D008631:Mercury Radioisotopes / Q000032:analysis; D000442:Octanols; D009941:Organomercury Compounds / Q000032:analysis; D012995:Solubility; D014867:Water
D008631:Mercury Radioisotopes; D000442:Octanols; D009941:Organomercury Compounds; D014867:Water; D008628:Mercury