Phosphatidylinositol composition in pancreas and submaxillary gland of ethanol-fed rats.
The possibility that changes in the stimulus-secretion coupling are involved in the etiology of pancreatitis was investigated by analysis of the molecular composition of the phosphatidylinositols in pancreas of rats fed a liquid ethanol-containing diet and pair-fed controls. The arachidonoyl-containing phosphatidylinositols were about half as abundant in the ethanol-fed rats. Opposite differences were seen for the major species containing linoleoyl, oleoyl or stearoyl groups at C-2. Ethanol-induced lipid peroxidation did not seem to be involved, since carbon tetrachloride administration had no effect on the composition. In the submaxillary gland, that has a similar stimulus-secretion coupling, the arachidonoyl-containing phosphatidylinositols constituted about a 25% smaller fraction in the ethanol-fed rats. Dexamethasone administration did not change the effect. Possibly, decreased secretory response in these glands in ethanol-fed rats is caused by the change in phosphatidylinositol composition.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D008297:Male; D010179:Pancreas / Q000032:analysis / Q000187:drug effects*; D010716:Phosphatidylinositols / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000032:analysis / Q000187:drug effects*
D010716:Phosphatidylinositols; D000431:Ethanol; D003907:Dexamethasone