title: The U.S. Transuranium Registry report of the 241Am content of a whole body. Part IV: Preparation and analysis of the tissues and bones.
abstract: Los Alamos National Laboratory has analyzed autopsy tissue for the USTR, as a part of its study of the uptake, distribution and retention of Pu and other transuranic elements in occupationally exposed workers since 1978. In April 1979, Los Alamos received the internal organs and bone samples from the first whole-body donation to the USTR. The donor was known to have an internal deposition of 241Am. All soft tissue, the bones from the right half of the skeleton, and the odd-numbered vertebrae were received at Los Alamos in February 1980. The bones were subdivided along anatomical areas of interest. All soft tissues and bone specimens were analyzed for their 241Am content. A total deposition of 147.4 nCi 241Am was measured. Approximately 18% of the 241Am remaining in the body (disregarding that in the left hand), was found in the soft tissues, and 82% was in the bones and teeth. The soft tissues and organs containing the largest amounts of 241Am were the combined soft tissue (striated muscle, connective tissue and skin) 8.8%; liver, 6.4% and respiratory tract, 1.5%. The remaining organs accounted for 0.9% of the systemic burden.
mesh_terms: D000576:Americium / Q000009:adverse effects / Q000032:analysis* / Q000378:metabolism; D001344:Autopsy; D001842:Bone and Bones / Q000032:analysis*; D003238:Connective Tissue / Q000032:analysis; D006801:Humans; D008099:Liver / Q000032:analysis; D008297:Male; D008433:Mathematics; D008545:Melanoma / Q000032:analysis; D008875:Middle Aged; D009132:Muscles / Q000032:analysis; D009381:Neoplasms, Radiation-Induced / Q000032:analysis; D010384:Pelvic Bones / Q000032:analysis; D011005:Plutonium / Q000032:analysis; D012137:Respiratory System / Q000032:analysis; D012867:Skin / Q000032:analysis; D012886:Skull / Q000032:analysis; D014018:Tissue Distribution
chemical_list: D011005:Plutonium; D000576:Americium