Reversible nutritional myopathy with myotonia in the protein-deficient rat given methionine.
Rats fed a protein-deficient synthetic diet developed hind limb weakness caused by a myopathy with myotonic features on electromyography. Deficiency of vitamin E and selenium, known causes of nutritional myopathy, were excluded. Methionine supplementation of the diet reversed the clinical signs of weakness within 12 h.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002364:Caseins / Q000032:analysis; D004576:Electromyography; D005526:Food, Formulated / Q000009:adverse effects* / Q000032:analysis; D007958:Leukocyte Count; D008715:Methionine / Q000032:analysis / Q000627:therapeutic use*; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D009222:Myotonia / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D011488:Protein Deficiency / Q000150:complications*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D002364:Caseins; D008715:Methionine