[A method of quality control of 3-phenyl-5-methylisoxazole-4-carbonic acid chloranhydride using high performance liquid chromatography].
A method of quantitative determination of 3-phenyl-5-methyl-isoxazole-4-carbonyl chloride useful for its qualitative estimation at all stages of oxacillin industrial synthesis was developed. The methods is based on transformation of this semi-product into isopropyl ester followed by high efficiency liquid chromatography with the use of the "Milikhrom" chromatograph mad in the USSR. A variant of the typical method for determination of 3-phenyl-5-methyl-isoxazole-4-carbonyl chloride concentration in solution is described.
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D005260:Female; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000302:isolation & purification*; D008297:Male; D010068:Oxacillin / Q000138:chemical synthesis*; D010080:Oxazoles / Q000302:isolation & purification*; D011786:Quality Control; D011817:Rabbits; D013678:Technology, Pharmaceutical / Q000592:standards
D007555:Isoxazoles; D010080:Oxazoles; C045708:3-phenyl-5-methylisoxazole-4-carbonyl chloride; D010068:Oxacillin
Metod kontrolia kachestva khlorangidrida 3-fenil-5-metilizoksazol-4-karbonovoĭ kisloty s pomoshch'iu vysokoéffektivnoĭ zhidkostnoĭ khromatografii.