Electroencephalographic activity after kainic and ibotenic acid injections in the amygdaloid complex of rats.
Long-term electroencephalographic (EEG) activity and neuropathological effects were studied after unilateral amygdaloid injections of kainic acid (KA) and ibotenic acid (IBO). Injections of 0.2 microgram KA caused severe epileptiform activity which lasted up to postoperative day 49. Complete losses of neuronal and glial elements appeared as cavities within the injected areas. Epileptiform activity after injections of 3.0 micrograms IBO was seen only as interictal spikes which lasted for 2-4 h after surgery. Cavities within the lesion areas were also evident in the IBO-injected rats. The results suggest that KA should be avoided as a lesion method in behavioral studies of brain functions, whereas IBO is judged to be a more suitable lesion tool, which produces only transitory and negligible epileptiform activity. However, neither KA nor IBO seems to have long-term fiber-sparing properties.
D000679:Amygdala / Q000187:drug effects* / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced; D007051:Ibotenic Acid / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage*; D008297:Male; D010080:Oxazoles / Q000008:administration & dosage*; D011759:Pyrrolidines / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D010080:Oxazoles; D011759:Pyrrolidines; D007051:Ibotenic Acid; D007608:Kainic Acid