Tobacco constituents are mitogenic for arterial smooth-muscle cells.
Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
D000818:Animals; D000941:Antigens / Q000494:pharmacology; D001013:Aorta, Thoracic; D001158:Arteries / Q000166:cytology; D002417:Cattle; D005347:Fibroblasts / Q000187:drug effects; D005419:Flavonoids; D006023:Glycoproteins; D066298:In Vitro Techniques; D008934:Mitogens; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D010636:Phenols / Q000494:pharmacology; D010940:Plant Proteins; D010947:Plants, Toxic; D011108:Polymers / Q000494:pharmacology; D012431:Rutin / Q000494:pharmacology; D012710:Serum Albumin, Bovine; D012906:Smoke; D013329:Structure-Activity Relationship; D013638:Tars / Q000494:pharmacology; D014026:Nicotiana
D000941:Antigens; D005419:Flavonoids; D006023:Glycoproteins; D008934:Mitogens; D010636:Phenols; D010940:Plant Proteins; D011108:Polymers; D012906:Smoke; C046039:TGP protein, Nicotiana tabacum; D013638:Tars; D012710:Serum Albumin, Bovine; D012431:Rutin