Increased serum triacylglycerol and cholesterol binding reserve in acute uremic rats.
In acute uremic rats (24 h after bilateral nephrectomy, serum urea 280-300 mg/dl) the interface tension of the serum is significantly reduced. Serum levels of triacylglycerol are significantly elevated in uremia, whereas cholesterol levels do not show a significant alteration. The in vitro serum binding reserve for both, triacylglycerol and cholesterol is considerably enhanced. These results let suppose the presence of tenside-like substances in uremic serum which may be involved in disturbed triacylglycerol transport from the serum to the tissues and in development of uremic hypertriglyceridemia.
D000208:Acute Disease; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004586:Electrophoresis; D008074:Lipoproteins / Q000097:blood / Q000145:classification; D008297:Male; D009392:Nephrectomy; D051381:Rats; D014280:Triglycerides / Q000097:blood*; D014511:Uremia / Q000097:blood*
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol