Influence of N-acetylcysteine on the hexachlorobenzene induced porphyria in rats.
The course of hexachlorobenzene (HCB) induced porphyria was not influenced by the concomitant administration of N-acetylcysteine (NAC) to the animals: urinary excretion of total porphyrins and porphyrin precursors as well as the hepatic aminolevulinate synthase activities were not influenced by NAC treatment. In addition, no differences could be shown between the HCB and the HCB/NAC combination group concerning the hepatic cytochrome P-450 contents or the P-450 dependent enzyme activities.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D002722:Chlorobenzenes / Q000633:toxicity*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006581:Hexachlorobenzene / Q000633:toxicity*; D008099:Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002722:Chlorobenzenes; D011166:Porphyrins; D006581:Hexachlorobenzene; D006899:Mixed Function Oxygenases; D000624:5-Aminolevulinate Synthetase; D005978:Glutathione; D000111:Acetylcysteine