title: Nucleotide sequence of yellow fever virus: implications for flavivirus gene expression and evolution.
abstract: The sequence of the entire RNA genome of the type flavivirus, yellow fever virus, has been obtained. Inspection of this sequence reveals a single long open reading frame of 10,233 nucleotides, which could encode a polypeptide of 3411 amino acids. The structural proteins are found within the amino-terminal 780 residues of this polyprotein; the remainder of the open reading frame consists of nonstructural viral polypeptides. This genome organization implies that mature viral proteins are produced by posttranslational cleavage of a polyprotein precursor and has implications for flavivirus RNA replication and for the evolutionary relation of this virus family to other RNA viruses.
mesh_terms: D001483:Base Sequence; D005075:Biological Evolution; D005786:Gene Expression Regulation; D005796:Genes; D006023:Glycoproteins / Q000235:genetics; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D012367:RNA, Viral / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*; D014779:Virus Replication; D015005:Yellow fever virus / Q000235:genetics*
chemical_list: D006023:Glycoproteins; D012367:RNA, Viral; D014764:Viral Proteins