title: Differentiation of the rat epididymis after withdrawal of androgen.
abstract: The differentiation capacity of the rat epididymis after depletion of androgen was studied in organ culture and in castrated rats. The differentiation of "narrow cells' in 5- and 10-day-old explants and in 10-day-old castrated rats suggests that: (i) the testicular androgens are not essential for their differentiation, (ii) a differential androgen dependence exists among the epididymal cell types, (iii) the undifferentiated epithelial cells are the precursors of the narrow cells.
mesh_terms: D000728:Androgens / Q000502:physiology*; D000818:Animals; D002369:Castration; D002454:Cell Differentiation / Q000187:drug effects; D004822:Epididymis / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009924:Organ Culture Techniques; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000728:Androgens