Effects of ethanol on the lipid composition of bovine vascular smooth muscle cells in culture.
Ethanol (50 mM) had no effect on the growth rate or viability of arterial smooth muscle cells over 3.5 days. The cholesterol:phospholipid ratio of the cells was unchanged after 7 days exposure. The major phospholipid components phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol were unchanged by ethanol exposure. Sphingomyelin content fell significantly within 12 hr. There were major changes in the fatty acid composition of the phospholipids with a reduction in saturated fatty acids and an increase in unsaturated fatty acids.
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D002784:Cholesterol / Q000032:analysis; D000431:Ethanol / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis*; D009131:Muscle, Smooth, Vascular / Q000032:analysis / Q000187:drug effects*; D010743:Phospholipids / Q000032:analysis
D008055:Lipids; D010743:Phospholipids; D000431:Ethanol; D002784:Cholesterol