Neurosecretory response of hypothalamic-hypophyseal axis to spinal anesthesia, minor gynecological surgery and irradiation.
The effect of spinal anesthesia, dilatation and curettage plus the first intracavitary radiotherapy or only that of intracavitary radiotherapy on growth hormone (HGH = the response of anterior pituitary) and arginine vasopressin (AVP = the response of posterior pituitary) levels was studied in 10 patients suffering from cervical or endometrial uterine cancer. Differing from earlier animal studies, irradiation had no effect on GH or AVP secretion, nor was there any change in the hormone levels following spinal anesthesia and dilatation and curettage. The neurosecretory response of hypothalamic-hypophyseal axis to spinal anesthesia and minor gynecological surgery appears to be minimal.
D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001127:Arginine Vasopressin / Q000494:pharmacology; D001918:Brachytherapy / Q000009:adverse effects*; D004107:Dilatation and Curettage / Q000009:adverse effects*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D009994:Osmolar Concentration; D011863:Radioimmunoassay
D001127:Arginine Vasopressin; D013006:Growth Hormone