title: Toxic effects of the soluble skin secretion from the Arabian Gulf catfish (Arius thallasinus, Ruppell) on plasma and liver enzyme levels.
abstract: Injection of skin toxin into the marginal ear vein of rabbits resulted in acute respiratory distress and convulsive movements, followed by death within 7 min. Significant increases in total plasma lactate dehydrogenase and the hepatic and cardiac derived isozymes and in glutamic-oxaloacetic and glutamic-pyruvic transaminase activities were observed in animals receiving toxin. Lower doses of toxin increase the survival time and enzyme levels in plasma. Skin toxin produces a time dependent toxic effect on the liver and heart.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004798:Enzymes / Q000097:blood / Q000378:metabolism*; D005260:Female; D005400:Fishes, Poisonous; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008387:Marine Toxins / Q000494:pharmacology*; D011817:Rabbits; D012867:Skin / Q000378:metabolism*; D013937:Thymidine Kinase / Q000097:blood / Q000378:metabolism
chemical_list: D004798:Enzymes; D007527:Isoenzymes; D008387:Marine Toxins; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013937:Thymidine Kinase