Xorphanol.
Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009019:Morphinans / Q000494:pharmacology* / Q000633:toxicity; D009020:Morphine / Q000037:antagonists & inhibitors; D010146:Pain / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D019966:Substance-Related Disorders / Q000209:etiology; D013997:Time Factors; D014554:Urination / Q000187:drug effects
D009019:Morphinans; D009020:Morphine; C030122:N-(cyclobutylmethyl)-8 beta-methyl-6-methylenemorphinan-3-ol