title: Sodium transport and electrical properties of the chick chorioallantoic membrane.
abstract: Transport and electrical properties of the chick chorioallantoic membrane (CAM) were studied in order to find the osmoregulatory organ which helps to compensate the renal filtration-reabsorption disbalance of chick embryos. It could be shown that CAM resembles Na+ transporting epithelia in that active Na+ absorption is responsible for the potential difference and short circuit current, which could be abolished by ouabain on the ectodermal and amiloride on the endodermal side. The transepithelial conductance rose with increasing sodium concentration in accordance with the Michaelis-Menten kinetics. The allantoic sac thus plays a role similar to the toad urinary bladder despite the low potential difference and resistance which indicate that CAM is a leaky epithelium. CAM is therefore not only a respiratory but also an osmoregulatory organ.
mesh_terms: D000481:Allantoin / Q000502:physiology*; D000818:Animals; D001693:Biological Transport, Active; D002642:Chick Embryo; D002823:Chorion / Q000502:physiology*; D004553:Electric Conductivity / Q000187:drug effects; D004558:Electric Stimulation; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D007700:Kinetics; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*
chemical_list: D000481:Allantoin; D010042:Ouabain; D012964:Sodium