Variability in the pharmacokinetics of atenolol and metoprolol.
18 healthy volunteers received conventional atenolol (Tenormin) 50 mg once daily and metoprolol 50 mg twice daily for 6 days in a balanced randomised cross-over fashion. There was a wash-out period of two weeks between each phase. Plasma concentrations of the drugs were measured on the last day of each phase. Comparison of the coefficients of variation showed a lower variability in the pharmacokinetics of atenolol compared to metoprolol. The clinical implications of these findings are discussed.
D000293:Adolescent; D000328:Adult; D001262:Atenolol / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D008790:Metoprolol / Q000097:blood*; D011897:Random Allocation
D001262:Atenolol; D008790:Metoprolol