Subset specificity of lupus antilymphocyte antibodies studied by two-colour microfluorimetry.
Subset specific lymphocytotoxic activity of lupus sera was studied by a combination of selective immunofluorescence labelling and complement-mediated lysis. Most frequently death of B cells was detected. Many of the sera caused lysis of T lymphocytes; selective cytotoxicity against suppressor T cells could be observed less frequently. All the anti-T4, anti-T8 and anti-B lymphocyte antibodies proved to be cold reactive.
D000918:Antibody Specificity; D000961:Antilymphocyte Serum / Q000276:immunology*; D005470:Fluorometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008214:Lymphocytes / Q000145:classification / Q000276:immunology
D000961:Antilymphocyte Serum