Rapid induction of cirrhosis by administration of carbon tetrachloride plus phospholipase D.
A new and rapid method for the production of liver cirrhosis in the rat is described. Rats were treated with carbon tetrachloride for 4 weeks and then injected i.p. with phospholipase D daily for 6 days. Controls received either carbon tetrachloride or phospholipase D only. Following the combined treatment cirrhosis developed rapidly; the liver developed micronodules and severe cirrhosis was accompanied by ascites and splenomegaly.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004357:Drug Synergism; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008722:Methods; D010739:Phospholipase D / Q000633:toxicity*; D010740:Phospholipases / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002251:Carbon Tetrachloride; D010740:Phospholipases; D010739:Phospholipase D