title: Retrograde amnesia produced by electron beam exposure: causal parameters and duration of memory loss.
abstract: The production of retrograde amnesia (RA) upon electron beam exposure has been investigated. RA production was evaluated using a single-trial avoidance task across a 10(4) dose range for 10-, 1-, and 0.1-microsecond pulsed exposures. The dose-response curve obtained at each pulse duration showed significant RA production. The most effective dose range was 0.1-10 rad at a dose rate of 10(6) rad/sec. By employing a 10 rad (10(6) rad/sec) pulse, a memory loss of the events occurring in the previous 4 sec was demonstrated. The conclusion was that the RA effect might be due to sensory system activation which provided a novel stimulus that masked previous stimuli.
mesh_terms: D000647:Amnesia / Q000209:etiology*; D000648:Amnesia, Retrograde / Q000209:etiology*; D000818:Animals; D001362:Avoidance Learning / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D008297:Male; D008568:Memory / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time