title: Influence of secretagogues on volume and protein pattern in rabbit lacrimal fluid.
abstract: After certain tear proteins had been found to be markers of duct cell activity in the rabbit lacrimal gland, different secretagogues were tested to increase volume and protein secretion. Carbamyl-choline and the peptides eledoisin and vasoactive intestinal peptide (VIP) stimulated volume flux as well as secretion of the marker proteins indicating duct cell activation. Beta-adrenergic stimulation also increased secretion of a further tear protein. This might indicate that water is secreted by the duct cells. These are stimulated by the secretagogues mentioned above. Beta-adrenergic stimulation might in addition activate the acinar cell system.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004586:Electrophoresis; D004600:Eledoisin / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005136:Eye Proteins / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D011817:Rabbits; D013268:Stimulation, Chemical; D013565:Sympatholytics / Q000494:pharmacology; D013666:Tears / Q000187:drug effects / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
chemical_list: D005136:Eye Proteins; D013565:Sympatholytics; D014660:Vasoactive Intestinal Peptide; D004600:Eledoisin; D001285:Atropine; D002217:Carbachol; D010869:Pindolol; D004837:Epinephrine; D010646:Phentolamine