Dopamine changes the shape of action potentials in hippocampal pyramidal cells.
Dopamine was found to have two electrophysiological effects on CA1 pyramidal cells in rat hippocampal slices. It increased the slow afterhyperpolarisation caused by a slow Ca2+-activated K+ conductance and it had an effect on action potentials that is postulated to be due to an increase in a fast Ca2+-activated K+ conductance. A given CA1 cell showed either one or both of the two responses to dopamine, or no response.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D051381:Rats
D004298:Dopamine