[Comparative evaluation of the myelotoxic action of rubomycin, adriamycin and carminomycin by their delayed effects in an experiment].
The experiments were performed on intact noninbred rats and BALB/c mice with the use of different models of the hemopoiesis compensatory-functional tension and the morphofunctional methods. It was shown that at the period of complete recovery of the morphological composition of the peripheral blood 30 days after discontinuation of the 10-day course of daily administration of rubomycin, adriamycin and carminomycin in equivalent doses (1/10 of the LD50) pronounced inhibition of hemopoiesis was preserved in the animals. This could not be detected with the routine methods used for investigation of the cell homeostasis and was evident from limited compensatory reactions of granulocytopoiesis and erythropoiesis under conditions of additional action on hemopoiesis.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002360:Carubicin / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
Sravnitel'naia otsenka mielotoksicheskogo deĭstviia rubomitsina, adriamitsina i karminomitsina po otsrochennym ĕffektam v ĕksperimente.