[Mechanisms of the synergistic action of ionizing radiation and hydrogen peroxide on the viability of bacteria].
The combined effect of ionizing radiation and minor concentrations of hydrogen peroxide (0.1-0.01 M) has been studied on bacteria differing in the cell wall structure (Gy+, Gy-), radioresistance, and activity of DNA repair system. The H2O2 concentrations applied, which have a slight antibacterial action, enhance significantly the bactericidal effect of ionizing radiation producing a synergistic effect due to the decreased effectiveness of repair of DNA single-strand breaks.
D001419:Bacteria / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D002473:Cell Wall / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D004269:DNA, Bacterial / Q000528:radiation effects; D004357:Drug Synergism / Q000528:radiation effects; D005720:Gamma Rays; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D011836:Radiation Tolerance; D013482:Superoxide Dismutase / Q000528:radiation effects
D004269:DNA, Bacterial; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase
Mekhanizmy sinergicheskogo deĭstviia ioniziruiushchego izlucheniia i perekisi vodoroda na zhizhnesposobnost' bakteriĭ.