title: The role of a reaction-diffusion system in the initiation of primary hair follicles.
abstract: A mechanism based on a reaction-diffusion system is proposed for the initiation of hair follicles in the epidermis during fetal development. It is demonstrated that initiation of primary follicles in a series of waves, within the proposed mechanism, is a consequence of the size and shape dependent properties of the reaction-diffusion system without the need for the propagation of signals through the skin. The observed trio grouping of follicles and variation of primary follicle density per unit skin area during development are also correctly predicted. An explanation, based on the reaction-diffusion system and the variation of its characteristic spatial wavelength with time during development, is suggested for the termination of both primary and secondary follicle initiation as well as follicle neogenesis. The proposed initiation mechanism is basically the same as that used to explain various spatial patterns observed in hair fibre formation (Nagorcka & Mooney, 1982).
mesh_terms: D000818:Animals; D004058:Diffusion; D006197:Hair / Q000196:embryology*; D008954:Models, Biological; D009024:Morphogenesis; D012756:Sheep; D014935:Wool / Q000196:embryology