[Synthesis and analysis of glycol bis-phosphates, regulators of reversible hemoglobin oxygenation].
Bisphosphates of glycols, ethyleneglycol and 1,2-propanediol, were synthesized. These structural analogues of 2,3-diphosphoglyceric acid were shown to reduce significantly the oxygen affinity of stripped hemoglobin.
D000494:Allosteric Regulation; D055598:Chemical Phenomena; D002621:Chemistry; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D005026:Ethylene Glycols / Q000138:chemical synthesis* / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D011409:Propylene Glycols / Q000138:chemical synthesis* / Q000494:pharmacology
D004163:Diphosphoglyceric Acids; D005026:Ethylene Glycols; D006454:Hemoglobins; D010108:Oxyhemoglobins; D011409:Propylene Glycols; C046519:1,2-propanediol bisphosphate; C046520:ethylene glycol bisphosphate; D010100:Oxygen
Sintez i isledovanie bisfosfatov glikoleĭ, reguliatorov obratimoĭ oksigenatsii gemoglobina.