[Dark adaptation of the photoreceptors in the isolated frog retina during induced lipid peroxidation].
The influence of lipid peroxidation (LPO) in isolated frog retina on dark adaptation of photoreceptors was studied. Stimulus-response functions, late receptor potential (LRP) as function of the stimulus light intensity were measured before bleach and in a steady state after dark adaptation. It was shown that accumulation of LPO products influenced dark adaptation in photoreceptors. Based on the displacements of the stimulus-response curves and experimental measurement data on the rate of LRP collapse after retina treatment with strophanthin it is concluded that the most probable mechanism of such an influence lies in a change of photoreceptor plasma membrane permeability.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D003623:Dark Adaptation / Q000187:drug effects; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D010775:Photic Stimulation / Q000379:methods; D010786:Photoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D011895:Rana ridibunda; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D013328:Strophanthins / Q000494:pharmacology
D008054:Lipid Peroxides; D013328:Strophanthins; D002084:Butylated Hydroxytoluene; C029082:strophanthin K; D001205:Ascorbic Acid
Temnovaia adaptatsiia fotoretseptorov izolirovannoĭ setchatki liagushki v usloviiakh indutsirovannogo lipopereokisleniia.