title: A defective ecotropic provirus closely linked to the albino locus.
abstract: A congenic mouse strain (NFS.C) carrying the albino region of chromosome 7 from strain C58/Lw on an ecotropic virus-negative NFS background inherited a noninducible but apparently full-size provirus reactive with an ecotropic virus-specific probe. This unexpressed ecotropic provirus maps close to the albino locus but is distinct from the Fgv-1 provirus located in the same region. The presence of this unique provirus in the albino region of chromosome 7 is potentially important, since it may provide a means of obtaining molecular clones of a chromosomal region, deletions of which are involved in profound metabolic, reproductive, and embryological abnormalities.
mesh_terms: D000417:Albinism / Q000235:genetics; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D003673:Defective Viruses / Q000235:genetics* / Q000254:growth & development; D005814:Genes, Viral; D008040:Genetic Linkage; D051379:Mice / Q000235:genetics / Q000382:microbiology*; D011995:Recombination, Genetic; D012190:Retroviridae / Q000235:genetics* / Q000254:growth & development; D014775:Virus Activation