[Dependence of the effect of vasodilator preparations on the initial distensibility of the vascular bed].
Acute experiments on anesthetized cats under extracorporeal circulation were made to study the effects of papaverine, phentolamine and dihydroergotamine on the blood flow-pressure relations of the vascular bed of the greater circulation. It was shown that the drug-induced change in the vascular resistance were dependent on the perfusion flow and on the initial distensibility of arterial vessels as well. A mathematical simulating model that permits fore-telling alterations in the vascular resistance is described.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004548:Elasticity; D008365:Manometry / Q000379:methods; D008433:Mathematics; D014655:Vascular Resistance / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents
Zavisimost' éffekta sosudorasshiriaiushchikh preparatov ot iskhodnoĭrastiazhimostisosudistogo rusla.