Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin.
The activation of Lys-plasminogen to plasmin by streptokinase was promoted by soluble fibrin such that Km was decreased and Vmax. increased. Enhancement was also observed when Glu-plasminogen was the substrate and was shared by the preformed streptokinase-plasminogen activator complex, indicating that the stimulation was not exerted primarily on the rate of active site formation.
D001665:Binding Sites; D004347:Drug Interactions; D005337:Fibrin / Q000378:metabolism*; D007700:Kinetics; D046911:Macromolecular Substances; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D013300:Streptokinase / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D046911:Macromolecular Substances; D005337:Fibrin; D010958:Plasminogen; D013300:Streptokinase; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator