[Characteristics of the mechanism of action of complex copper (II) compounds with alpha-amino acids].
There was no direct inhibition of DNA synthesis in ascites hepatoma 22A cells after intraperitoneal injection of single doses of copper (II) complexes with amino acids into tumor-bearing C3HA mice. Meanwhile cis-dichlorodiamine platinum (II) (DDP) as well as sarcolysine showed such inhibition. Copper (II) complexes with alpha-amino acids displayed as significant superoxide dismutase-like activity at concentrations corresponding to therapeutic doses of these compounds. The complexes of copper (II) combined with DDP give an additive antitumor effect in solid tumors of mice.
D000596:Amino Acids / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D003300:Copper / Q000627:therapeutic use* / Q000633:toxicity; D004273:DNA, Neoplasm / Q000037:antagonists & inhibitors; D004151:Dipeptides / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D008558:Melphalan / Q000627:therapeutic use; D051379:Mice; D008809:Mice, Inbred C3H; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors
D000596:Amino Acids; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004151:Dipeptides; D003300:Copper; D013482:Superoxide Dismutase; D002945:Cisplatin; D008558:Melphalan
Nekotorye osobennosti mekhanizma deĭstviia kompleksnykh soedineniĭ nedi (II) s al'fa-aminokislotami.