Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets.
Cells from the cerebral proliferative zones of newborn ferrets were labeled with tritiated thymidine and a fluorescent dye and were transplanted as a single-cell suspension into the occipital region of newborn ferrets. The transplanted cells became thoroughly integrated into the host environment: many cells migrated through the intermediate zone and into the cortical plate, where they developed as pyramidal neurons. Other transplanted cells came to resemble glial cells. After 1 to 2 months most transplanted neurons had taken up residence in layer 2 + 3, the normal destination of neurons generated on postnatal days 1 and 2. Thus the sequence of morphological differentiation and the eventual laminar position of the isochronically transplanted neurons closely paralleled that of their normal host counterparts.
D000578:Amidines; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002454:Cell Differentiation; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development / Q000502:physiology; D005289:Ferrets; D005456:Fluorescent Dyes; D007211:Indoles; D009474:Neurons / Q000145:classification / Q000502:physiology / Q000637:transplantation*
D000578:Amidines; D005456:Fluorescent Dyes; D007211:Indoles; C031455:diamidino compound 253-50; C007293:DAPI