title: Changes in the affinity of [3H]nimodipine binding sites in the brain upon chlorpromazine treatment and subsequent withdrawal.
abstract: Male mice were chronically treated with chlorpromazine mixed in powdered diet, and the properties of brain calcium channels were assessed using [3H]nimodipine binding. It was found that this treatment resulted in a significant increase in the affinity of calcium channels, without a significant change in their density. These effects of chlorpromazine were time dependent. When mice were administered chlorpromazine for 2 months, then the drug was withdrawn, there was a rebound decrease in the channel affinity.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009539:Nicotinic Acids / Q000378:metabolism*; D009553:Nimodipine; D013375:Substance Withdrawal Syndrome; D014316:Tritium
chemical_list: D002121:Calcium Channel Blockers; D009539:Nicotinic Acids; D014316:Tritium; D009553:Nimodipine; D002746:Chlorpromazine