Cardiovascular alterations in severe pregnancy-induced hypertension seen with an intravenously given hydralazine bolus.
The acute cardiovascular effects of a 10 milligram bolus of hydralazine was found to cause a significant increase in heart rate and cardiac index while decreasing mean arterial pressure and systemic vascular resistance index. A wide spectrum of individual responses was seen in terms of peak effects and duration of effects. The role of hydralazine in patients with severe pregnancy-induced hypertension was discussed and possible alternative therapy is suggested.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects
D006830:Hydralazine