Syncarcinogenic effects of methyl methanesulfonate with methylazoxymethanol acetate in rat small intestine and liver.
The carcinogenic potency of methyl methanesulfonate (MMS) and its combination effect with methylazoxymethanol (MAM) acetate were evaluated in rats. MMS was suggested to be weakly carcinogenic for the small intestine. Syncarcinogenic effects of MMS and MAM acetate which could be due to summation of their genotoxic influences were obtained in the small intestine and liver.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D003043:Cocarcinogenesis; D004357:Drug Synergism; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity*; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D051381:Rats; D011912:Rats, Inbred ACI
D001391:Azo Compounds; D008746:Methylazoxymethanol Acetate; D008741:Methyl Methanesulfonate