Effects of topical retinoic acid on intracutaneously implanted S91 melanoma in mice.
Previous studies have demonstrated that retinoids possess antineoplastic properties against melanoma. The purpose of this study was to determine whether topically applied retinoic acid could prevent melanoma development in syngeneic mice after intracutaneous cell inoculation. Trans-retinoic acid in DMSO was applied daily for 28 days after melanoma implantation and tumor growth was quantitated by the uptake of [14C]thiouracil, a tracer compound specific for melanoma which is incorporated linearly according to the weight of the tumor. Marked reduction in tumor growth was noted at the highest concentration (0.1%) tested and lesser but significantly decreased tumor growth patterns were also realized at lower concentrations in a dose-dependent manner. Thus, topically applied retinoic acid is capable of inhibiting S91 melanoma growth in vivo.
D000287:Administration, Topical; D000818:Animals; D002250:Carbon Radioisotopes; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D013889:Thiouracil / Q000378:metabolism; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use*
D002250:Carbon Radioisotopes; D014212:Tretinoin; D013889:Thiouracil; D004121:Dimethyl Sulfoxide