title: The interaction of genetic drift and mutation with selection in a fluctuating environment.
abstract: The interaction of genetic drift, mutation, and selection in a random environment is investigated using an asymptotic analysis based on assumptions of weak mutation and strong selection. It is shown that genetic drift can be a potent force for removing variation from the population when the random environment tends to occasionally push alleles down to low frequencies.
mesh_terms: D000818:Animals; D004777:Environment; D005787:Gene Frequency; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D012641:Selection, Genetic