[Syndrome of amyotrophic lateral sclerosis after thymectomy performed for myasthenic syndrome].
A case of amyotrophic lateral sclerosis was observed developing three months after thymectomy in a woman aged 52 years. The patient had been referred for thymectomy because of myasthenic signs increasing in intensity since 2 years. Myasthenia was confirmed by electrophysiological investigations, and the diagnosis was: myasthenic syndrome and suspected thymoma. During nearly 5 years of follow-up the following observations were made: there was a correlation between thymectomy and the development of ALS syndrome, thymosine administration produced clinical improvement, thymosine administration improved the function of thymus-dependent lymphocytes, thymosine withdrawal (due to non-availability) produced exacerbation of symptoms.
D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000601:surgery*; D013934:Thymectomy / Q000009:adverse effects*; D013949:Thymus Extracts / Q000627:therapeutic use
D013949:Thymus Extracts
Zespół stwardnienia zanikowego bocznego po tymektomii wykonanej z powodu zespołu miastenicznego.