title: Effects of cold exposure on calcitonin secretion in the young rat.
abstract: The effects of cold exposure on calcitonin (CT) secretion were evaluated in young rats. Acute cold exposure (5 h to 5 degrees C) induced a rise in plasma CT concentrations and a decrease in thyroidal CT stores without change in total and ionized plasma calcium levels. The cold activation of sympathico-adrenomedullary axis and the inhibition of CT response to cold after beta-antagonist treatment might suggest that endogenous catecholamines can enhance CT secretion in young rats. Cold adaptation (3 weeks to 5 degrees C) induced a fall in plasma calcium concentration and a rise in thyroidal CT stores without change in plasma CT levels. The high plasma glucocorticoid levels which are known to occur during chronic cold exposure could be involved in the rise of thyroidal CT content in cold adapted rats.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002116:Calcitonin / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D003080:Cold Temperature; D008297:Male; D010710:Phosphates / Q000097:blood; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000032:analysis; D013997:Time Factors
chemical_list: D010710:Phosphates; D002116:Calcitonin; D011433:Propranolol; D002118:Calcium