Nickel penetration in allergic individuals: bioavailability versus X-ray microanalysis detection.
Development of local allergic reactions after different application times with Finn Chambers was recorded in 34 nickel-sensitive patients. Biologically significant amounts of nickel seemed to penetrate the skin within a few hours, although physical penetration was minimal. Nickel was detected only in the upper keratin cell layer with an X-ray microanalysis method.
D000328:Adult; D001682:Biological Availability; D003877:Dermatitis, Contact / Q000209:etiology; D005260:Female; D006801:Humans; D009532:Nickel / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000648:ultrastructure; D013997:Time Factors
D009532:Nickel