Peroxidase activity at nodes of Ranvier in some commonly used laboratory animals after intramuscular administration of horseradish peroxidase.
During retrograde transport of intramuscularly administrated horseradish peroxidase (HRP) nodal axon segments of rabbit, rat, and mouse peripheral nerve fibers became HRP-positive and showed a striking proximodistal segregation of certain axoplasmic organelles. HRP-positive bodies and HRP-negative vesiculotubular membrane profiles were seen just distal and proximal to the nodal midlevel, respectively. This appearance was similar to that found earlier in HRP-transporting feline muscle nerve fibers. Some mechanisms that might explain the segregated appearance are briefly discussed.
D000818:Animals; D002415:Cats; D006735:Horseradish Peroxidase / Q000008:administration & dosage; D007273:Injections, Intramuscular; D010544:Peroxidases; D011817:Rabbits; D011901:Ranvier's Nodes / Q000648:ultrastructure*; D012377:Rodentia
D006735:Horseradish Peroxidase; D010544:Peroxidases