title: Experimental morphological studies on the functional role of the pulpal nerves in dentinogenesis.
abstract: The role of the pulpal nerves in the dentinogenesis of the rat dentition was studied experimentally by means of a time marker of lead acetate and by electron microscope after the individual dissection of the trigeminal and cervical sympathetic nerves or both. Following trigeminectomy, the longitudinal growth of the denervated incisor decreased. Contrary to this, following cervical sympathectomy, the longitudinal growth of the denervated incisor and molar increased 10-5%, and the collagen fibers increased predominantly in the pulpal tissue. The sympathetic nerves seem to play an important part in controlling the differentiation of the odontoblasts, inhibiting the maturation of the growth center of the apical pulp in the continuously developing teeth.
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003714:Denervation; D003782:Dental Pulp / Q000294:innervation*; D003810:Dentinogenesis; D007180:Incisor / Q000254:growth & development; D007854:Lead; D008854:Microscopy, Electron; D008963:Molar / Q000254:growth & development; D009412:Nerve Fibers / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009942:Organometallic Compounds; D051381:Rats; D012183:Retrograde Degeneration; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology* / Q000601:surgery
chemical_list: D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate