Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule.
After vaginal insertion of a 300-mg ovule of tioconazole in 10 patients with vaginal candidiasis, the mean concentration in plasma was 21.2 ng/ml (range, 10.6 to 35.8 ng/ml) at 8 h and was not measurable at 24 h in 9 of 10 patients. The mean vaginal concentration at 24 h was 21.4 mg/liter (range, 2.4 to 50 mg/liter) and remained detectable in 7 of 9 and 2 of 9 patients after 48 and 72 h, respectively.
D000042:Absorption; D000935:Antifungal Agents / Q000008:administration & dosage / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000378:metabolism*; D013488:Suppositories; D013997:Time Factors; D014621:Vagina / Q000378:metabolism*
D000935:Antifungal Agents; D007093:Imidazoles; D013488:Suppositories; C020527:tioconazole