New antitumor antibiotics, FR-900405 and FR-900406. I. Taxonomy of the producing strain.
An actinomycete which was isolated from a soil sample produces new antitumor substances. The morphological and cultural characteristics of the strain resemble those of the genera Streptomyces Waksman and Henrici 1943 and Actinomadura Lechevalier and Lechevalier 1970. Cell wall composition analysis showed that strain No. 6049 contained meso-2,6-diaminopimelic acid in its cell wall, and madurose in whole-cell sugars. No sporangia, zoospores or fragmentations of vegetative mycelium are observed. From these results, strain No. 6049 is designated as Actinomadura pulveracea sp. nov.
D000192:Actinomycetales / Q000145:classification* / Q000254:growth & development / Q000648:ultrastructure; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D003960:Diaminopimelic Acid / Q000032:analysis; D008854:Microscopy, Electron; D062367:ortho-Aminobenzoates / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D062367:ortho-Aminobenzoates; C046601:FR 900406; D003960:Diaminopimelic Acid; C046600:FR 900405