Ocular inserts for application of drugs to bovine eyes--in vitro studies on gentamicin release from collagen inserts.
Soluble collagen and insoluble collagen films were impregnated with gentamicin and investigated in vitro as vehicles for the delivery drugs. Succinylated collagen released significantly higher levels of antibiotic than the insoluble films, and maintained mean inhibitory concentrations (MIC) for Moraxella bovis for 24 h.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003094:Collagen; D005839:Gentamicins / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D007637:Keratoconjunctivitis / Q000188:drug therapy / Q000662:veterinary*; D014677:Pharmaceutical Vehicles; D012995:Solubility
D005839:Gentamicins; D014677:Pharmaceutical Vehicles; D003094:Collagen