Glutathione reductase deficiency in association with sickle cell and thalassaemia genes in Saudi populations.
Glutathione reductase (GR) deficiency is reported to occur with a variable frequency in some populations of the world. In this study, the populations of two regions of Saudi Arabia which have a high frequency of sickle cell, thalassaemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, were screened for GR deficiency. Studies were also carried out to investigate the frequency of GR deficiency with other genetic blood disorders. The frequencies of complete GR deficiency were 0.0065 and 0.006, while those of partial deficiency were 0.146 and 0.074 in Al-Hafouf and Khaiber, respectively. GR deficiency was encountered in combination with the sickle gene, the G-6-PD deficiency gene and the thalassaemia gene in both regions. Individuals with GR deficiency showed slightly reduced haematological parameters. In thalassaemic/GR-deficient subjects, mean cell volume and mean cell haemoglobin were low, while in sickle cell anaemia patients with GR deficiency the haematological parameters were higher than in sickle cell anaemia patients without GR deficiency.
D000755:Anemia, Sickle Cell / Q000150:complications / Q000235:genetics*; D004777:Environment; D005260:Female; D008040:Genetic Linkage; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000235:genetics; D005980:Glutathione Reductase / Q000172:deficiency / Q000235:genetics*; D006801:Humans; D008297:Male; D012529:Saudi Arabia; D012959:Socioeconomic Factors; D013789:Thalassemia / Q000150:complications / Q000235:genetics*
D005980:Glutathione Reductase