title: Acute haemodynamic responses to unilateral renal artery stenosis in conscious dogs.
abstract: The acute responses to renal artery stenosis were studied in chronically instrumented, unanaesthetized dogs. Stenosis of one renal artery produced a rise in arterial pressure and a fall in total peripheral conductance, but no change in cardiac output. The resistance to blood flow of the stenotic kidney 1 h after stenosis was 25% greater than before stenosis. This rise in resistance was due to the resistance of the renal artery stenosis itself. Blood flow to the contralateral kidney fell by 13% (s.e.m. = 3) at 1 h and resistance rose by 39% (s.e.m. = 5). Plasma renin activity was elevated approximately 10 fold. Calculations of changes in peripheral conductances following stenosis showed that the stenotic kidney was responsible for 14% of the fall in total peripheral conductance at 1 h, and the contralateral kidney for 18%. Thus acute renal artery stenosis produced a prompt rise in arterial pressure due to reduced peripheral conductance, of which the two kidneys (stenotic and contralateral) were responsible for one-third.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D006439:Hemodynamics; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008297:Male; D012078:Renal Artery Obstruction / Q000503:physiopathology*; D012079:Renal Circulation