The role aortic chemoreceptors during severe CO hypoxia.
The importance of aortic chemoreceptors in the circulatory responses to severe carbon monoxide (CO) hypoxia was studied in anesthetized dogs. The aortic chemoreceptors were surgically denervated in eight dogs prior to the induction of CO hypoxia, with nine other dogs serving as intact controls. Values for both whole body and hindlimb blood flow, vascular resistance, and O2 uptake were determined prior to and at 30 min of CO hypoxia in the two groups. Arterial O2 content was reduced 65% using an in situ dialysis method to produce CO hypoxia. At 30 min of hypoxia, cardiac output increased but limb blood flow remained at prehypoxic levels in both groups. This indicated that aortic chemoreceptor input was not necessary for the increase in cardiac output during severe CO hypoxia, nor for the diversion of this increased flow to nonmuscle tissues. Limb O2 uptake decreased during CO hypoxia in the aortic-denervated group but remained at prehypoxic levels in the intact group. The lower resting values for limb blood flow in the aortic-denervated animals required a greater level of O2 extraction to maintain resting O2 uptake. When CO hypoxia was superimposed upon this compensation, an O2 supply limitation occurred because the limb failed to vasodilate even as maximal levels for O2 extraction were approached.
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002249:Carbon Monoxide Poisoning / Q000378:metabolism* / Q000503:physiopathology; D002302:Cardiac Output / Q000187:drug effects; D002628:Chemoreceptor Cells / Q000378:metabolism*; D003486:Cyanides / Q000494:pharmacology; D004285:Dogs; D006614:Hindlimb / Q000098:blood supply; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009121:Muscle Denervation; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D003486:Cyanides; D010100:Oxygen