Ultrastructure of the epithelial cells of the small intestinal villi, the surface epithelium of the large intestinal mucosa and some elements of the intestinal mucosal lamina propria in rats with acute uraemia.
Electron microscopic studies on the dynamics of changes in the epithelial cells and some elements of the intestinal mucosal lamina propria were performed on rats after bilateral high ureter ligation. Simultaneously, they were referred to blood serum biochemical and electrolyte disturbances. The ultrastructural changes indicate that as early as in the initial period of acute uraemia water-electrolyte disturbances become evident, which are still increasing. In the later period cell organelles alter and bacterial infection sets in. Ultrastructural abnormalities of the intestinal mucous membrane are increasing proportionally to biochemical and electrolyte disturbances of the blood serum.
D000818:Animals; D004848:Epithelium / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors; D014511:Uremia / Q000473:pathology*