[Changes in the chemotherapy sensitivity of leukemia L1210 cells during the development of diazan resistance].
L 1210 leukemia strain resistant to diazan (L 1210/D1) was studied for its drug sensitivity in comparison with the parent strain. The resistant strain exhibited significantly higher sensitivity to nine drugs: dopan, sarcolysine, apirazidin, cyclophosphane, 6-mercaptopurine, thiophosphamide, rubomycin, vinblastine and vincristine. L 1210/D1 gained cross resistance to four drugs: 1-(2-chloroethyl)-3-(2, 6-dioxy-3-piperidyl)-1-nitrosourea, methotrexate, 5-fluorouracil and ftorafur. The resistant strain sensitivity remained unchanged (in comparison with the parent strain) to seven drugs: degranol, prospidin, nitrosomethylurea, chlorozotocin, deazauridine, bleomycin and L-asparaginase (crasnitine).
D000818:Animals; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors*; D003979:Diazonium Compounds / Q000037:antagonists & inhibitors*; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice
D000970:Antineoplastic Agents; D003979:Diazonium Compounds; C000279:diazan
Izmenenie chuvstvitel'nosti k khimioterapii kletok leĭkoza L1210 pri razvitii ustoĭchivosti k diazanu.