Increased mitochondrial creatine kinase in chronically stimulated fast-twitch rabbit muscle.
Fractional extraction and isozyme electrophoresis revealed the presence of small amounts (2.5% of total cellular activity) of mitochondrial creatine kinase (CK) in rabbit fast-twitch muscle. Chronic nerve stimulation resulted in a decrease of extramitochondrial MM-CK to 60% of its normal value but induced an approx. 4-fold increase in mitochondrial CK. This increase occurred in parallel with the rise in enzyme activities of terminal substrate oxidation.
D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D004558:Electric Stimulation; D004586:Electrophoresis; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology*; D009132:Muscles / Q000201:enzymology; D010084:Oxidation-Reduction; D011817:Rabbits
D003402:Creatine Kinase