title: Rapid gas chromatographic determination of ethylene oxide, ethylene chlorohydrin, and ethylene glycol residues in rubber catheters.
abstract: Isothermal gas chromatography with flame ionization detection was used to determine residual ethylene oxide (EtO), ethylene chlorohydrin, and ethylene glycol in soft rubber catheters that had been sterilized with EtO. Catheter samples were extracted by shaking with carbon disulfide, and the extract was analyzed on a 3% Carbowax 20M on 80-100 mesh Chromosorb 101 column, using nitrogen as the carrier gas. Ten replicate injections of a mixed standards solution gave coefficients of variation of 1.91, 1.23, and 4.74% for EtO, ethylene chlorohydrin, and ethylene glycol, respectively. A linear response was obtained with concentrations ranging from 1.0 to 7.9 micrograms EtO, 14.0 to 88.0 micrograms ethylene chlorohydrin, and 31.0 to 98.5 micrograms ethylene glycol. The proposed method detected as little as 0.5, 5.0, and 16.5 ng EtO, ethylene chlorohydrin, and ethylene glycol, respectively.
mesh_terms: D002404:Catheterization / Q000295:instrumentation; D002728:Chlorohydrins / Q000032:analysis*; D002849:Chromatography, Gas; D005023:Ethylene Chlorohydrin / Q000032:analysis*; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000032:analysis*; D005027:Ethylene Oxide / Q000032:analysis*; D012408:Rubber / Q000032:analysis*; D012997:Solvents
chemical_list: D002728:Chlorohydrins; D005026:Ethylene Glycols; D012997:Solvents; D005023:Ethylene Chlorohydrin; D012408:Rubber; D019855:Ethylene Glycol; D005027:Ethylene Oxide