[Dynamics of the ultrastructure of fibroblasts during pre- and postnatal development of the dermis in the rat according to electronic morphometry].
Fibroblasts have been investigated in 18-day-old embryos, in newborns, in 2-week-old and in 2-month-old rats of postnatal development. Comparison of fibroblasts population is specific for each stage. Average section area of the fibroblasts nucleus is progressively decreasing during ontogenesis. Average section area of cytoplasm reaches its maximum by the end of the second week of the life and then decreases sharply, and therefore the nucleus/cytoplasm ratio in the fibroblasts is minimal at the age of two weeks. The Golgi complex section area decreases significantly in mature animals as compared to the young ones. Summational extent of the granular endoplasmic reticulum membranes in the fibroblast section in the 2-week-old animals is 2.5 times as great as the corresponding parameters in the fetuses, newborns and mature animals. This parameter is greatly informative for determining the fibroblast type in accordance with its synthetic activity.
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D005347:Fibroblasts / Q000648:ultrastructure*; D008854:Microscopy, Electron; D051381:Rats; D012867:Skin / Q000166:cytology* / Q000196:embryology / Q000254:growth & development
Dinamika ul'trastruktury fibroblastov v protsesse pre- i postnatal'nogo razvitiia dermy krys po dannym élektronnoĭ morfometrii.