Efficacy of immunoglobulins in gram-negative infections in experimentally induced peritonitis in the rat.
The effect of adjuvantly administered, newly developed immunoglobulin preparations in combination with an antibiotic is investigated by means of an animal experimental model. The animal model was peritonitis which was induced by a left-open colotomy in the rat. Administration of a combination therapy of immunoglobulins and an antibiotic succeeded in reducing lethality and shock index (according to Staub [15]) significantly by up to 50% as compared to the untreated control group. Using sub-therapeutic dosage of the antibiotic (50% of the human equivalent dose) the synergistic effect of the immunoglobulins could be confirmed clearly. A single summation of the offered immunoglobulin preparations cannot achieve an improvement in the results. In the present examinations additional IgM-enrichment does not result in a further improvement over the usually normal immunoglobulin levels in the preparations.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000628:therapy*; D004357:Drug Synergism; D006090:Gram-Negative Bacteria; D007116:Immunization, Passive; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size; D010538:Peritonitis / Q000628:therapy*; D051381:Rats; D013997:Time Factors
D000900:Anti-Bacterial Agents