[Enhancement of the immune response to surface antigens of the influenza B virus as a result of their covalent binding with a synthetic polymer carrier].
The primary immune response (the number of antibody-forming cells, AFC) and the delayed type hypersensitivity (DTHS) were studied in mice immunized either with isolated glycoproteins of influenza virus (hemagglutinin, HA and HA plus neuraminidase, HA plus NA) or with their conjugates with an acrylic acid copolymer (CP) and N-vinylpyrrolidone of equimolar composition. Immunization of mice with conjugates containing virus proteins (virogates-HA-CP or HA plus NA-CP--entailed a 50-100 increment of the number of IgM- and IgG-AFC, anti-HA as compared with analogous parameters during immunization of animals with isolated virus proteins. Immunization of mice with the virogate HA-CP gives rise to the development of a more pronounced DTHS to HA. The authors discuss the possibility of the use of this basically new approach to the design of highly immunogenous vaccine preparations, effective in the control of influenza and other virus diseases.
D000180:Acrylic Resins / Q000276:immunology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D006389:Hemagglutinins, Viral / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007114:Immunization; D009980:Influenza A virus / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009439:Neuraminidase / Q000276:immunology
D000180:Acrylic Resins; D000954:Antigens, Surface; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D009439:Neuraminidase
Usilenie immunnogo otveta k poverkhnostnym antigenam virusa grippa v rezul'tate ikh kovalentnogo sviazyvaniia s sinteticheskim polimerom-nosi-telem.