title: Akinesia and mutism following a methylphenidate challenge test.
abstract: A case of akinesia and mutism is described in a menopausal, depressed woman with onset following a mood challenge with 40 mg of methylphenidate taken orally over a 3-hour period. Various diagnoses are considered with preference given on clinical grounds to conversion disorder precipitated by drug-induced dysphoria. It is suggested that increased susceptibility to dysphoria may have been related to prior clomipramine administration and hypoestrogenism.
mesh_terms: D000328:Adult; D000405:Akinetic Mutism / Q000139:chemically induced* / Q000175:diagnosis; D002389:Catatonia / Q000175:diagnosis; D003291:Conversion Disorder / Q000175:diagnosis; D003866:Depressive Disorder / Q000188:drug therapy; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000175:diagnosis; D005260:Female; D006801:Humans; D008774:Methylphenidate / Q000009:adverse effects*
chemical_list: D008774:Methylphenidate