Alternative explanations for normal variability in antithrombin-III levels.
Data collected in a study of ATIII deficiency also suggested familial variability of blood clotting times amongst genotypically normal individuals. A study of this variability under a variety of models demonstrates a clear age effect and within sibship similarity. There is also a clear parental effect, which could be either environmental or genetic. Even when parental effects are taken into account there remains some excess similarity between sibs, but the increase in log-likelihood provided by this component is no longer highly significant.
D000704:Analysis of Variance; D000990:Antithrombin III / Q000235:genetics*; D020152:Antithrombin III Deficiency; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D012016:Reference Values
D000990:Antithrombin III