title: Haemorrhage decreases the anaesthetic requirement for ketamine and thiopentone in the pig.
abstract: The anaesthetic requirements of ketamine and thiopentone were studied in eight pig littermates during normovolaemia and after haemorrhage (30% blood loss). Four animals received ketamine and four thiopentone, and the minimal anaesthetic doses of both drugs were determined. Moderate hypovolaemia decreased the anaesthetic requirements significantly and similarly: thiopentone 33 +/- 5%; ketamine 40 +/- 5% (mean +/- SEM).
mesh_terms: D000771:Anesthesia, Intravenous; D000818:Animals; D001810:Blood Volume; D006470:Hemorrhage / Q000503:physiopathology*; D007649:Ketamine / Q000008:administration & dosage*; D013552:Swine; D013874:Thiopental / Q000008:administration & dosage*
chemical_list: D007649:Ketamine; D013874:Thiopental