Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration.
Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil (A-OT) against MH134 solid tumors in mice was studied following subcutaneous and oral administration and compared with that of 5-fluorouracil (5-FU) administered subcutaneously at doses of 0.2, 0.4 and 0.6 mmol/kg/d. Oral administration of A-OT demonstrated a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of A-OT. Anti-tumor activity of oral administration of A-OT at a dose of 0.2 mmol/kg/d was comparable to that of subcutaneous administration of 5-FU at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of A-OT at any dose were smaller than those by subcutaneous administration of 5-FU (0.2 mmol/kg/d).
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects
D000970:Antineoplastic Agents; C020186:1-acetyl-3,2-toluyl-5-fluorouracil; D005472:Fluorouracil