Reduced levels of plasma ascorbic acid (vitamin C) in sickle cell disease patients: its possible role in the oxidant damage to sickle cells in vivo.
The role of oxidant damage to red cells in sickle cell disease has been of interest in recent years. Ascorbic acid is a well known antioxidant. The present study found that sickle cell patients have low levels of plasma ascorbic acid. In addition, it was observed that the pretreatment of sickle cells with ascorbic acid protects their membranes against in vitro peroxidative lipid damage induced by their exposure to hydrogen peroxide. The data suggest that low plasma ascorbic acid levels in sickle cell patients may be a factor in the increased vulnerability of sickle cells to oxidant damage in vivo.
D000755:Anemia, Sickle Cell / Q000097:blood*; D001205:Ascorbic Acid / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D010545:Peroxides / Q000494:pharmacology
D010545:Peroxides; D008315:Malondialdehyde; D001205:Ascorbic Acid