Experimental 3-nitro-4-hydroxyphenylarsonic acid toxicosis in pigs.
Five times the recommended dose of 3-nitro-4-hydroxyphenylarsonic acid (187.5 mg kg-1) induces a pathognomonic clinical syndrome in pigs. The main clinical features are not continually present but are inducible only by exercise. From day 11 on the experimental diet a nervous syndrome was inducible. This manifested as muscle tremors and clonic convulsive episodes. Paraparesis developed by day 22 and paraplegia by day 33. Liver arsenic levels plateaued at 5.4 +/- 1.3 mg kg-1. The experiment confirms field observations that 3-nitro produces a characteristic toxicological syndrome, which is distinct from that of arsanilic acid. It also confirms that 3-nitro has a higher absolute toxicity than arsanilic acid in pigs as well as a lower margin of safety.
D000818:Animals; D001147:Arsanilic Acid / Q000506:poisoning; D001151:Arsenic / Q000378:metabolism; D020261:Arsenic Poisoning; D004890:Erythema / Q000662:veterinary*; D005243:Feces / Q000032:analysis; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D010264:Paraplegia / Q000662:veterinary*; D012406:Roxarsone / Q000506:poisoning*; D012640:Seizures / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism / Q000503:physiopathology*; D013577:Syndrome / Q000662:veterinary; D013997:Time Factors
D012406:Roxarsone; D001151:Arsenic; D001147:Arsanilic Acid