Identification of genotoxic and epigenetic carcinogens in liver culture systems.
Liver culture systems are available for identifying the DNA reactivity of carcinogens and a cell membrane effect, which appears to be associated with neoplasm-promoting ability. Using these and other approaches, carcinogens can be categorized as genotoxic or epigenetic. This distinction has implications for risk assessment.
D000818:Animals; D002273:Carcinogens / Q000032:analysis; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009153:Mutagens / Q000032:analysis; D013045:Species Specificity
D002273:Carcinogens; D009153:Mutagens