Repigmentation of vitiligo macules treated topically with Efudix cream.
Repigmentation has been observed under the influence of topically administered Efudix cream in 3 patients with vitiligo of symmetrical acral type. No response has been received in 2 patients with segmental vitiligo treated in the same way. Recurrence of vitiligo was seen in 1 patient. Histologic and electron microscopic characterization of recolonized melanocytes is described. The significance of topical 5-fluorouracil treatment in vitiligo is discussed.
D000287:Administration, Topical; D000328:Adult; D002648:Child; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D009824:Ointments; D012867:Skin / Q000473:pathology; D012880:Skin Pigmentation / Q000187:drug effects*; D014820:Vitiligo / Q000188:drug therapy* / Q000473:pathology
D009824:Ointments; D005472:Fluorouracil