title: Effect of narcotic premedication on scintigraphic evaluation of gallbladder perforation.
abstract: A case of gallbladder perforation is presented in which a small bile leak was demonstrated by cholescintigraphy while the patient was receiving meperidine, but not after meperidine was discontinued. The scintigrams obtained during meperidine therapy also showed a pattern of bile-duct obstruction. It is suggested that increased biliary pressure secondary to meperidine administration permitted visualization of the leak. Use of narcotic drugs may be a useful pharmacologic intervention in cases of peritonitis due to small or obscure bile leaks.
mesh_terms: D000328:Adult; D003135:Common Bile Duct / Q000000981:diagnostic imaging / Q000187:drug effects*; D003937:Diagnosis, Differential; D005704:Gallbladder / Q000000981:diagnostic imaging* / Q000293:injuries; D006801:Humans; D007098:Imino Acids; D008297:Male; D008614:Meperidine / Q000494:pharmacology* / Q000627:therapeutic use; D011292:Premedication; D011677:Punctures; D011877:Radionuclide Imaging; D013667:Technetium; D019785:Technetium Tc 99m Disofenin
chemical_list: D007098:Imino Acids; D013667:Technetium; D008614:Meperidine; D019785:Technetium Tc 99m Disofenin