title: Intracellular ionic changes during hyperthermia of tumor cells in the presence of lanthanum.
abstract: The experimental data suggest that permeability changes at the plasma membrane level are the most likely cause of the enhancement of tumor cell killing by hyperthermia in the presence of 1 mM La3+. The interaction of La3+ with the Na+, K+ ATPase and Ca2+-pump ATPase may be the probable cause of dramatic electrolyte changes which enhance the hyperthermia effects on tumor cells.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D002470:Cell Survival; D004573:Electrolytes / Q000378:metabolism*; D006358:Hot Temperature; D007811:Lanthanum / Q000494:pharmacology*; D008560:Membrane Fluidity; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012413:Rubidium / Q000378:metabolism
chemical_list: D004573:Electrolytes; D007811:Lanthanum; D012413:Rubidium; D011188:Potassium; D002118:Calcium