Increased frequency of lymphocytic mitotic non-disjunction in recurrent spontaneous aborters.
Hypermodal chromosomal spreads occurred significantly more frequently in lymphocytes from couples with recurrent spontaneous abortion than from comparison populations. Previously, we reported a similarly increased frequency in couples with aneuploid offspring. Considering the frequency of aneuploidy among first trimester spontaneous abortions, we suggest that there may be a sub-population of persons predisposed to non-disjunction among couples with reproductive wastage.
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D002478:Cells, Cultured; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008423:Maternal Age; D008938:Mitosis; D009630:Nondisjunction, Genetic; D010331:Paternal Age; D011247:Pregnancy