Decreased cerebrospinal fluid glutamine levels in patients with benign brain tumors.
CSF glutamine concentrations were studied in 12 patients with benign brain tumors (meningioma, craniopharyngioma, or osteofibroma), 12 patients with malignant brain tumors (astrocytoma, medulloblastoma, pinealoblastoma, or chondrosarcoma), 9 patients with noncerebral tumors, and a reference group of 24 patients. The mean +/- SD levels in the benign tumor group (424 +/- 124 microM) were significantly lower (p less than 0.0004) than those in the reference group (642 +/- 195 microM). There was no significant difference between the CSF glutamine concentrations in the malignant cerebral tumor group (643 +/- 210 microM) or noncerebral tumor group (599 +/- 127 microM) and those in the reference group. In patients with benign brain tumors there was indication of an inverse linear relationship between the logarithm of CSF glutamine concentration and tumor diameter.
D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000134:cerebrospinal fluid; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid*; D002528:Cerebellar Neoplasms / Q000134:cerebrospinal fluid; D002648:Child; D002813:Chondrosarcoma / Q000134:cerebrospinal fluid; D003397:Craniopharyngioma / Q000134:cerebrospinal fluid; D005260:Female; D005350:Fibroma / Q000134:cerebrospinal fluid; D005973:Glutamine / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000134:cerebrospinal fluid; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid; D008579:Meningioma / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010016:Osteoma / Q000134:cerebrospinal fluid; D010871:Pinealoma / Q000134:cerebrospinal fluid; D010911:Pituitary Neoplasms / Q000134:cerebrospinal fluid
D005973:Glutamine