Sicca syndrome in mesangial IgA glomerulonephritis.
Schirmer-test, history of conjunctivitis, salivary gland scintigraphy and SSA/SSB (Ro/La) antibodies were evaluated in 24 patients with mesangial IgA glomerulonephritis (IgA-GN), 58 patients with non-IgA-GN and 100 healthy controls. A sicca syndrome (positive Schirmer-test) was found in 46% of patients with IgA-GN and 17% of non-IgA-GN and 8% of controls (p less than 0.001). Only one of the IgA-GN patients volunteered a history of xerosis of the conjunctiva, but upon questioning 17% reported a history of ophthalmological treatment for recurrent conjunctivitis. The observation adds another extrarenal facet to the syndrome of mesangial IgA-GN. Diminished tear production may be another (immune?) abnormality of the oropharyngeal system.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005920:Glomerular Mesangium; D005922:Glomerulonephritis, IGA / Q000150:complications*; D006801:Humans; D007637:Keratoconjunctivitis / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged