[Effects of gefarnate on acute gastric lesions in rats].
The effects of gefarnate on several acute gastric lesions were studied in rats. Gefarnate, given at either 100 approximately 1000 mg/kg orally or intraduodenally, dose-dependently inhibited the formation of gastric lesions induced by HCl-ethanol, HCl-taurocholate and aspirin. Cimetidine, given at 30 approximately 100 mg/kg as a reference drug, also significantly inhibited both HCl-ethanol and aspirin-induced lesions. The present study suggests that gefarnate, as well as cimetidine, is useful for the treatment of acute gastric lesions in man.
D000208:Acute Disease; D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors; D002927:Cimetidine / Q000627:therapeutic use; D000431:Ethanol / Q000037:antagonists & inhibitors; D005778:Gefarnate / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000139:chemically induced / Q000517:prevention & control*; D013656:Taurocholic Acid / Q000037:antagonists & inhibitors; D013729:Terpenes / Q000627:therapeutic use*
D013729:Terpenes; D005778:Gefarnate; D000431:Ethanol; D013656:Taurocholic Acid; D002927:Cimetidine; D001241:Aspirin