Effects of diethylstilboestrol-dipropionate on SCEs, micronuclei, cytotoxicity, aneuploidy and cell proliferation in maternal and foetal mouse cells treated in vivo.
The effect of diethylstilboestrol-dipropionate on the frequency of SCEs and micronuclei, cytotoxicity, aneuploidy and cell proliferation rates of foetal liver and maternal bone marrow cells following exposure of pregnant mice was measured. An increase in the number of aneuploid and polyploid cells was observed in both tissues. There was no effect on micronuclei frequency, SCE frequency, or cell proliferation rate.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000782:Aneuploidy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002875:Chromosomes / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000196:embryology; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects
D004054:Diethylstilbestrol; C000937:diethylstilbestrol dipropionate