Compartmentation of glycogen metabolism in the liver.
The incorporation of radioactivity into liver glycogen has been shown not only to be a metabolically inhomogeneous process but also to depend critically on the nature of the precursor. D-Galactose is incorporated into glycogen by a mechanism which is separate from that associated with the incorporation of D-glucose. D-Galactose is favoured for incorporation into high-molecular-weight glycogen and consequently is affected more by treatment of the animal with the antibiotic tunicamycin, since high-molecular-weight glycogen is preferentially found in the lysosomal compartment.
D000818:Animals; D002250:Carbon Radioisotopes; D005215:Fasting; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D008112:Liver Glycogen / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism
D002250:Carbon Radioisotopes; D008112:Liver Glycogen; D005947:Glucose; D005690:Galactose