Absence of initiating activity by quercetin in the rat liver.
Initiating activity of quercetin was tested in rats which were treated with partial hepatectomy and given a liver cancer promoter, phenobarbital. A few intestinal neoplasms were seen but without significant difference in incidence from those in the quercetin-untreated group. Moreover, neither neoplastic nor preneoplastic liver changes were detected in quercetin-treated groups. With hepatocyte primary culture/DNA repair test, quercetin did not produce genotoxicity. The results show that quercetin has no initiating or genotoxic activities in the rat liver.
D000818:Animals; D002273:Carcinogens; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D005419:Flavonoids / Q000633:toxicity*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D010634:Phenobarbital / Q000633:toxicity; D011794:Quercetin / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D002273:Carcinogens; D005419:Flavonoids; D011794:Quercetin; D010634:Phenobarbital