[Mechanism of the intensification of the immune response to Staphylococcus in mice after the transplantation of primed donor splenocytes].
Experiments on CBA, C57Bl/6 mice and (CBA X X C57Bl/6)F1 hybrids were made to study the mechanism of stimulation of the immune response to staphylococci after injection of primed splenocytes. The stimulating action of immune splenocytes was reversed after their in-vitro treatment with anti-immunoglobulin serum and complement. The stimulant effect was also seen in a semi-allogeneic system (adoptive transfer of CBA mice immune cells to (CBA X C57Bl/6)F1 recipients). Preincubation of splenocytes with CBA-anti-C57Bl/6-serum and complement prior to demonstration of antibody-forming cells did not influence their number in the spleen of hybrid recipients injected with immune cells carrying parent genotype but decreased this indicator of the immune response in control mice. It is concluded that stimulation of the immune response to staphylococci after transplantation of primed splenocytes is due to the anamnestic response of donor's cells repeatedly stimulated by antigen in the recipient's host.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology; D006168:Guinea Pigs; D007106:Immune Sera / Q000276:immunology; D007114:Immunization; D007136:Immunoglobulins / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits; D013154:Spleen / Q000276:immunology / Q000637:transplantation*; D013211:Staphylococcus aureus / Q000276:immunology*; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic
D000942:Antigens, Bacterial; D007106:Immune Sera; D007136:Immunoglobulins; D003165:Complement System Proteins
Mekhanizm usileniia immunnogo otveta na stafilokokk u mysheĭ pri transplantatsii spelnotsitov primirovannykh donorov.