Inhibition of 4-aminobutyric acid (GABA) turnover by chlordane.
4-Aminobutyric acid (GABA) turnover was measured in mice 8 h after an acute injection of 1 g/kg of technical grade chlordane in corn oil. Significant decreases in GABA turnover were observed in the cortex, striatum, hippocampus and hypothalamus after chlordane treatment. A smaller, though significant, decrease was also observed in the cerebellum. These results may help to explain the hyperexcitability and convulsions observed after acute high-dose exposure to this compound.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002531:Cerebellum / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002706:Chlordan / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D051379:Mice; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002706:Chlordan; D005680:gamma-Aminobutyric Acid