Hemodynamic studies in a parabiotic model of portal hypertension.
Splanchnic and systemic hemodynamic studies were performed in a rat model of parabiosis and portal hypertension. A portal hypertensive and a normal rat were surgically united side to side. A hyperdynamic circulation, characterized by increased cardiac index (413 +/- 26 vs 318 +/- 23 ml X min-1 X kg-1; p less than 0.05) and portal venous inflow (9.61 +/- 1.29 vs 6.33 +/- 0.36 ml X min-1 X 100 g b.wt-1; p less than 0.05), was found in all the portal hypertensive rats but not in the normal parabiotic partners. These results do not support the existence of a transferable humoral factor mediating the hyperdynamic circulatory state of chronic portal hypertension.
D000818:Animals; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000503:physiopathology*; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D010227:Parabiosis; D051381:Rats; D011919:Rats, Inbred Strains; D013152:Splanchnic Circulation