title: Stability of the amino acid content of nerve endings after administration of gamma-aminobutyrate agonists and antagonists.
abstract: The administration of GABA agonists or antagonists to mice resulted in unchanged levels of aspartate, glutamate, GABA and taurine in nerve endings (synaptosomes). On the other hand, agonist-induced increases in the levels of some of the amino acids occurred in locations other than the nerve endings. The GABA agonist SL75102 inhibited in vitro uptake of D-aspartate into synaptosomes, thereby raising the possibility that a similar phenomenon may cause an in vivo redistribution of glutamate and aspartate in brain tissue.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001224:Aspartic Acid / Q000378:metabolism; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D018756:GABA Antagonists; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D009411:Nerve Endings / Q000378:metabolism*; D010852:Picrotoxin / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000927:Anticonvulsants; D001224:Aspartic Acid; D001418:Baclofen; D001640:Bicuculline; D018756:GABA Antagonists; D009118:Muscimol; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C017985:progabide; C017984:progabide acid