The monensin-mediated transport of sodium ions through phospholipid bilayers studied by 23Na-NMR spectroscopy.
The monensin-mediated transport of sodium ions through the walls of large unilamellar vesicles of egg phosphatidylcholine was studied using 23Na-NMR and aqueous shift reagents. The transport is dynamic on the NMR time-scale and is strictly first order in monensin over the concentration ranges studied indicating that transport occurs by a 1:1 Na+-ionophore complex. Transport appears to be inhibited by increasing concentrations of Na+.
D001693:Biological Transport, Active; D005663:Furans / Q000494:pharmacology*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008985:Monensin / Q000494:pharmacology*; D010743:Phospholipids; D012964:Sodium / Q000378:metabolism*
D005663:Furans; D008051:Lipid Bilayers; D010743:Phospholipids; D008985:Monensin; D012964:Sodium