Erythroid progenitors in Rauscher leukemia virus variant-A-induced erythropoietic dysplasia in mice.
In vitro erythropoiesis by bone marrow and spleen cells was assessed in normal mice and during progression of Rauscher leukemia virus, variant-A (RLV-A) disease in mice. As RLV-A disease progressed from early through terminal stages, there was a marked increase in the numbers of in vitro splenic CFU-E and BFU-E. Conversely, bone marrow CFU-E and BFU-E demonstrated a concomitant decrease in numbers with disease progression. At no time were erythropoietin-independent (endogenous) erythroid colonies generated. The results suggest that compartmental alterations in erythroid precursors occur during progression of RLV-A.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000473:pathology*; D004920:Erythropoiesis; D007942:Leukemia, Experimental / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011925:Rauscher Virus; D013154:Spleen / Q000473:pathology; D013234:Stem Cells / Q000473:pathology*