Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing the Bowman-Birk protease inhibitor.
Dimethylhydrazine (DMH) induces adenocarcinomas of the colon and rectum in rodents; this animal cancer model system is thought to closely resemble human colorectal cancer. An extract of soybeans containing the Bowman-Birk protease inhibitor added to the diet of DMH-treated mice resulted in a significant suppression of adenomatous tumors of the colonic mucosa. Non-treated mice maintained on the same diet for most of their natural life-span (1.5 years) showed no observable health problems.
D000236:Adenoma / Q000517:prevention & control*; D000818:Animals; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004032:Diet; D004127:Dimethylhydrazines; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D013025:Glycine max / Q000032:analysis*
D004127:Dimethylhydrazines; D010936:Plant Extracts; D011480:Protease Inhibitors