title: Impaired lipid clearance in patients with previous acute pancreatitis.
abstract: Fasting serum triglycerides were measured in 52 patients who had sustained an attack of pancreatitis (gall stone related 33, alcoholism six) at least six months earlier. Several patients (23%) had raised fasting serum triglycerides, with a type IV phenotype in all but one patient. The 40 patients with normal fasting serum triglycerides received an oral load of 100 g sunflower oil to compare their clearance of dietary triglycerides with that of a control group of 54 subjects. The clearance of ingested triglycerides was significantly impaired in the patients - irrespective of the presumed aetiological factor, or clinical condition associated with pancreatitis - compared with the clearance in controls. A triglyceride tolerance test is the only way to detect those patients in whom a future attack of pancreatitis may be precipitated by a diet rich in fat, or endogenous over production of triglycerides as after an alcoholic debauch.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000008:administration & dosage; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009821:Oils / Q000008:administration & dosage; D010195:Pancreatitis / Q000097:blood*; D010938:Plant Oils; D011446:Prospective Studies; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood*
chemical_list: D004041:Dietary Fats; D009821:Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides