Corneal endothelial changes in diabetic dogs.
The corneal endothelium of alloxan diabetic dogs was examined by wide-field specular microscopy and compared to that of age-matched non-diabetic dogs. Computer-assisted morphometry of individual cells showed that the diabetic dog endothelium had marked polymegethism and pleomorphism similar to that previously described in diabetic patients. There also appeared to be a positive correlation between the degree of these endothelial changes and the diabetic control as demonstrated by HbA1 concentration.
D000496:Alloxan; D000818:Animals; D002452:Cell Count; D003315:Cornea / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000473:pathology*; D004285:Dogs; D004727:Endothelium / Q000473:pathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D008297:Male
D000496:Alloxan; D006442:Glycated Hemoglobin