title: Cutaneous manifestations of sarcoidosis. Relationships to other organ system involvement, abnormal laboratory measurements, and disease course.
abstract: The charts of 329 patients with sarcoidosis were reviewed to determine if there were significant associations between the presence of sarcoidosis skin lesions and other abnormalities. Sixty-four patients had either biopsy specimen-documented cutaneous granulomata or erythema nodosum (EN). Respiratory symptoms occurred in 41% of patients with skin lesions compared with 63% of patients with sarcoidosis without skin lesions. Among patients with skin lesions other than EN, splenomegaly occurred in 38%, hepatomegaly in 32%, and lymphadenopathy in 31% compared with 10%, 11%, and 56%, respectively, for patients with sarcoidosis without skin lesions. Thirty-two percent of patients with EN had progressive disease compared with 72% of patients with skin lesions other than EN; however, improved prognosis with EN was limited to white patients.
mesh_terms: D000328:Adult; D004893:Erythema Nodosum / Q000150:complications; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D008206:Lymphatic Diseases / Q000209:etiology; D008297:Male; D011379:Prognosis; D012507:Sarcoidosis / Q000150:complications*; D012871:Skin Diseases / Q000150:complications*; D013163:Splenomegaly / Q000209:etiology