title: Development of nongerm cell malignancies in nonseminomatous germ cell tumors.
abstract: We report 2 cases of sarcomatous transformation of mixed germ cell tumors of the testis. Both patients received cisplatin-based combination chemotherapy. Embryonal rhabdomyosarcoma, chondrosarcoma and spindle cell sarcoma were the dominant pathological patterns in the metastatic sites. Nongerm cell malignancies in mixed germ cell tumors following chemotherapy may be more common than previously described.
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002813:Chondrosarcoma / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage; D003238:Connective Tissue / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology; D008482:Mediastinum / Q000473:pathology; D009132:Muscles / Q000473:pathology; D009362:Neoplasm Metastasis; D012186:Retroperitoneal Neoplasms / Q000473:pathology; D012187:Retroperitoneal Space / Q000473:pathology; D012208:Rhabdomyosarcoma / Q000473:pathology*; D012509:Sarcoma / Q000473:pathology*; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D002945:Cisplatin