Striatal dopamine after cortical injury.
After right or left unilateral sensorimotor cortex ablation or a sham operation, dopamine concentrations were assayed in the right and left striatum of rats. In the sham-operated animals, a greater amount of dopamine was found in the left striatum compared with the right. Right or left sensorimotor cortex injury reduced dopamine in both striata. Right hemisphere lesions produced a greater loss of dopamine in the right striatum compared with the effect of a left lesion on dopamine in the left striatum. The results support the hypothesis of an asymmetric response to cortical injury.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013003:Somatosensory Cortex / Q000502:physiology*; D014018:Tissue Distribution
D004298:Dopamine