Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats.
The role of an endogenously occurring acetyl glyceryl ether phosphorylcholine (AGEPC) in blood pressure regulation was studied with an AGEPC antagonist in rats with hypertension of various etiologies. The hypotensive activity of an intravenously injected AGEPC was competitively suppressed by the intravenous infusion of 3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl-2-thiazolioethylphospha te (CV-3988) and was dose-dependent. The CV-3988 was infused intravenously into one- and two-kidney, one clip hypertensive, deoxycorticosterone-salt hypertensive, adrenal regeneration hypertensive, spontaneously hypertensive, and normotensive control rats. The increase in blood pressure caused by CV-3988 infusion in spontaneously hypertensive and normotensive control rats was significant (p less than 0.01 and p less than 0.001, respectively, at 60 min) compared with that caused by vehicle infusion. The increase was not seen in rats with secondary hypertension. In rats with two-kidney, one clip hypertension, the initial rapid decrease in blood pressure seen after unclipping was significantly (p less than 0.05) inhibited by CV-3988 infusion as compared with that by vehicle infusion. These results suggest that endogenous AGEPC may participate in the blood pressure regulation and pathophysiology of some forms of hypertension in rats.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010742:Phospholipid Ethers; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D011921:Rats, Inbred WKY; D013844:Thiazoles / Q000494:pharmacology
D010742:Phospholipid Ethers; D010972:Platelet Activating Factor; D013844:Thiazoles; D000804:Angiotensin II; C037913:CV 3988; D009638:Norepinephrine