title: [Anticonvulsive activity of anticonvulsants and tranquilizers when used together].
abstract: Experiments on mice were made to study anticonvulsive activity of the combinations of 5 tranquilizers (diazepam, chlorodiazepoxide, meprotan, trioxazin, mebicar) and 7 anticonvulsants (phenobarbital, hexamidine, benzonal, diphenin, chloracon, trimetin, carbamazepin) according to the maximal electroshock test. The data obtained form an experimental basis for the combined use of some anticonvulsants and tranquilizers in the treatment of epilepsy, since in a number of cases these combinations permit a significant lowering of the doses of both components without reducing their anticonvulsant activity.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D051379:Mice; D012640:Seizures / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D014149:Tranquilizing Agents
vernacular_title: Protivosudorozhnaia aktivnost' nekotorykh antikonvul'santov i trankvilizatorov pri ikh sovmestnom primenenii.