Oxyntomodulin (glucagon-37) and its C-terminal octapeptide inhibit gastric acid secretion.
Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA8) at its C-terminal end. In this study, the effect of OXM and KA8 on pentagastrin-stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25-450 pmol . kg-1) as well as KA8 (7.5-60 nmol . kg-1) inhibited pentagastrin-stimulated gastric acid output in a dose-dependent manner; KA8 was about 100-times less potent than OXM. In cats, KA8 (90 nmol . kg-1) was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C-terminal octapeptide of OXM is implicated in this effect.
D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D004763:Glucagon-Like Peptides / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D053772:Oxyntomodulin; D010418:Pentagastrin / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005768:Gastrointestinal Hormones; D009842:Oligopeptides; D053772:Oxyntomodulin; D010446:Peptide Fragments; D004763:Glucagon-Like Peptides; D010418:Pentagastrin