Nonorgan-specific autoantibodies and immunoglobulin allotypes in relatives of patients with monoclonal gammopathy.
Polyclonal immunoglobulin increase, rheumatoid factor, antinuclear antibodies and cold lymphocytotoxins were detected 10, 8, 7 and 8 times, respectively, in a group of these informative families (22, 17 and 29 subjects tested, respectively). Each family included at least 1 subject with a monoclonal gammopathy in addition to that of the proband. No correlation could be shown between any of these abnormalities and Gm haplotypes. Nonetheless, it is worth noting that 6 out of 41 relatives under 30 years of age had cold lymphocytotoxins.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D002648:Child; D002999:Clone Cells; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D010375:Pedigree
D001323:Autoantibodies; D007126:Immunoglobulin Allotypes