title: Histopathological study on rats fed iodine-enriched eggs long-term (7 and 19 months).
abstract: A histopathological study was conducted on rats fed on a diet containing iodine-enriched eggs over the long term, 7 and 19 months. A laboratory powder chow was added at the 1% (w/w) level with ordinary egg powder (ordinary egg diet as control: 35 micrograms iodine/100 g diet) or iodine-enriched egg powder (iodine-enriched egg diet: 392 micrograms iodine/100 g diet). The animals were meal-fed twice a day and allowed unrestricted voluntary wheel-running. In general, organs, tissues and endocrine glands including thyroid glands from rats of the iodine-enriched egg diet group exhibited no significant difference in histopathological features as compared with those of the ordinary egg diet group. These results suggest that long-term feeding of a considerable amount of iodine through an iodine-enriched egg diet did not cause any specific excess-iodine toxicity.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic; D001921:Brain / Q000033:anatomy & histology; D004032:Diet; D004531:Eggs; D006321:Heart / Q000033:anatomy & histology; D007455:Iodine / Q000008:administration & dosage* / Q000633:toxicity; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008168:Lung / Q000033:anatomy & histology; D008297:Male; D008321:Mammary Glands, Animal / Q000033:anatomy & histology; D010179:Pancreas / Q000033:anatomy & histology; D010902:Pituitary Gland / Q000033:anatomy & histology; D011467:Prostate / Q000033:anatomy & histology; D051381:Rats; D013737:Testis / Q000033:anatomy & histology; D013961:Thyroid Gland / Q000033:anatomy & histology
chemical_list: D007455:Iodine