Treatment of experimental lens capsular tears with intense focused ultrasound.
High-intensity focused ultrasound was employed to seal lens capsular tears in a rabbit model. Ultrasound therapy was applied either contiguously, thereby completely covering the tear, or in a discrete exposure pattern around the tear. Both methods prevented the formation of a generalised cataract. This was in contrast to results observed in a group of control (untreated) animals which all developed generalised lens opacities. Each control animal also developed a local lens opacity at the site of the capsular tear, as did half the animals treated with the discrete pattern. No animal treated with contiguous exposures developed any local or generalised traumatic-type cataract other than the small lens opacity immediately produced by the treatment. These treatment cataracts would not constitute a significant impediment to vision so long as they did not fall on the visual axis.
D000818:Animals; D002386:Cataract / Q000473:pathology / Q000517:prevention & control; D007903:Lens Capsule, Crystalline / Q000293:injuries* / Q000473:pathology; D007908:Lens, Crystalline / Q000293:injuries*; D011817:Rabbits; D014464:Ultrasonic Therapy