Radioiron utilization and gossypol acetic acid in male rats.
The 24-h incorporation of 59Fe into circulating red blood cells, bone marrow, urine, liver, spleen, and skeletal muscle was measured in splenectomized and sham-splenectomized rats which had received a daily, oral dose of gossypol acetic acid (20 mg GAA/kg body wt) for 91 days. A significant decrease in total body weight gain was observed in all GAA treated animals. Splenectomized rats dosed with GAA exhibited a significant decrease in hemoglobin concentration, hematocrit and erythrocyte count. A significant increase in 59Fe incorporation by red blood cells and a decrease in hepatic incorporation of 59Fe indicate a preferential utilization of iron in erythropoiesis among GAA treated animals.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects; D006072:Gossypol / Q000031:analogs & derivatives* / Q000633:toxicity; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D008297:Male; D051381:Rats; D013089:Spermatocidal Agents / Q000633:toxicity*; D013156:Splenectomy
D007504:Iron Radioisotopes; D013089:Spermatocidal Agents; D007501:Iron; D006072:Gossypol; C028178:gossypol acetic acid