[Effect of prednisolone, hyperbaric oxygenation and their combination on the glucose content of the blood and glycogen in the organs of white rats].
A single injection of prednisolone in doses of 10, 30, 80 and 100 mg/kg provoked different shifts in blood glucose concentration and glycogen content in the heart, liver, and skeletal muscles. Prednisolone increased liver glycogen content almost in all the doses. Administered in doses of 10 and 30 mg/kg the drug reduced blood glucose level and glycogen content in the myocardium and skeletal muscles. Administered in doses of 80 and 100 mg/kg the drug produced almost no effect on the characteristics under consideration or increased them. Oxygen raised glycogen liver content, blood glucose level, reduced the content of the polysaccharide in the skeletal muscles at a pressure of 3039 Pa (3 at. abs). Combined use of prednisolone and oxygen at an elevated pressure led, depending on the drug dose, to the occurrence of the phenomena of either synergism or antagonism.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006003:Glycogen / Q000378:metabolism*; D006321:Heart / Q000187:drug effects; D006931:Hyperbaric Oxygenation; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats
D001786:Blood Glucose; D008112:Liver Glycogen; D006003:Glycogen; D011239:Prednisolone
Vliianie prednizolona, giperbaricheskoĭ oksigenatsii i ikh sochetaniia na soderzhanie gliukozy v krovi i glikogena v organakh belykh krys.