Quality control of commercial 99mTc-human albumin kits.
The quality of a number of commercial human albumin kits used at Danish hospitals for preparation of 99mTc-labelled human serum albumin has been investigated by column chromatography and HPLC. In general, the radiochemical purity was found to be low (75% or less). In some cases with a poor radiochemical purity, the main radiochemical impurity, 99mTc-labelled tin colloid, amounted to 29% or more. A large molar tin to albumin ratio seems to lead to a low radiochemical purity and it is suggested that products with a high content of stannous chloride may be more correctly termed 99mTc-albumin/tin-colloid kits.
D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D003102:Colloids; D004340:Drug Contamination; D006801:Humans; D011786:Quality Control; D011933:Reagent Kits, Diagnostic / Q000592:standards*; D013667:Technetium; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin / Q000592:standards*; D014001:Tin; D017971:Tin Compounds
D003102:Colloids; D011933:Reagent Kits, Diagnostic; D017556:Technetium Compounds; D013668:Technetium Tc 99m Aggregated Albumin; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D013667:Technetium; D014001:Tin