[Differing microsomal monoxygenase activity in the cells of ascitic and solid forms of transplantable tumors].
Aryl hydroxylase activity has been demonstrated to depend on the pattern of tumor cell structural organization. The activity of microsomal monoxygenases in the ascitic forms of sarcoma MC-11, hepatoma 22a and Ehrlich's tumor was much lower than in the corresponding solid tumors. Aryl hydroxylase was activated after the animals received 3-MC, but the magnitude of the activity induced did not correlate with the basic activity in the different tumors. In in vitro experiments, 7,8-benzoflavone inhibited the enzyme in all the tumors, whereas metyrapone did not affect BP-hydroxylation. It is assumed that all the tumors investigated contain hemoprotein that is similar to cytochrome P1-450.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008861:Microsomes / Q000201:enzymology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology*; D010105:Oxygenases / Q000378:metabolism*; D012513:Sarcoma, Experimental / Q000201:enzymology
D010105:Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases
Razlichnaia aktivnost' mikrosomnykh monooksigenaz v kletkakh astsitnoĭ i solidnoĭ form perevivaemykh opukholeĭ.