title: gamma-Aminobutyric acid concentrations are maintained in anoxic turtle brain.
abstract: Changes in gamma-aminobutyric acid (GABA) concentrations in the turtle (Pseudemys scripta elegans) brain were studied in situ during prolonged anoxia. With the onset of anoxia, the well-documented rapid increases in GABA found in mammalian brains were not observed in the turtle brain. Although not statistically significant, mean GABA concentrations in the turtle brain were reduced from anesthetized control values during the first 30 min of anoxia. During this initial period brain glutamate content declined. Even after 2 h of nitrogen respiration, GABA in the turtle brain still did not rise above control levels. By the 4th h of anoxia, however, GABA had increased to 147% of control values.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000693:Anaerobiosis; D000818:Animals; D001921:Brain / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D007700:Kinetics; D010725:Phosphocreatine / Q000378:metabolism; D014426:Turtles; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D010725:Phosphocreatine; D005680:gamma-Aminobutyric Acid; D000255:Adenosine Triphosphate