[Effect of pro- and antioxidant food factors on macrophage oxidative metabolism].
The effects of vitamin E deficiency and excess polyunsaturated acids in the diet on luminol-dependent chemiluminescence were studied in Aug-Lac rats. It was chown that experimental prooxidant regiments led to the increase of oxidative metabolism in macrophages stimulated by opsonized zymozan. Vitamin E deficient regimens decreased superoxide dismutase activity of macrophages. In vitro DL-alpha-tocopherol and the synthetic antioxidants BHT and BHA inhibited chemiluminescence of macrophages. Arachidonic acid activated macrophages and induced the formation of oxygen radicals.
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage; D014811:Vitamin E Deficiency / Q000378:metabolism
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D014810:Vitamin E
Vliianie alimentarnykh faktorov pro- i antioksidantnogo deĭstviia na okislitel'nyĭ metabolizm makrofagov.