Sister chromatid exchanges in adult epileptic patients on phenytoin therapy.
Sister chromatid exchanges (SCE) were studied in lymphocyte cultures of 12 adult male epileptic patients on long-term monotherapy with phenytoin (PHT) and of matched controls. Significantly increased frequency of SCE was observed in the epileptic patients as a group and in almost all individuals, indicating a detectable chromosome damaging effect of PHT therapy on its human users.
D000328:Adult; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008214:Lymphocytes; D008875:Middle Aged; D009154:Mutation / Q000187:drug effects; D010672:Phenytoin / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013997:Time Factors
D010672:Phenytoin