Comparative pharmacokinetics of vitamin A (retinol) in rats and hamsters.
The absorption and elimination of all-trans-retinol in the plasma of rats and hamsters were studied after an oral dose of 45 mg/kg body weight. The hamsters exhibited a higher pretreatment mean circulating retinol concentration than rats maintained on an identical diet. The increase in plasma retinol after a single oral dose was much greater in hamsters than rats. The area under the plasma concentration v. time curve was approximately 60% greater for rats than for hamsters. The elimination half-times for rats were much longer than for hamsters. Plasma retinol uptake and disappearance were consistent with a two-compartment open model with first-order absorption.
D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D005260:Female; D006207:Half-Life; D007700:Kinetics; D008647:Mesocricetus; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood*
D014801:Vitamin A