A study of the penetration of temocillin in the cerebrospinal fluid.
Temocillin concentrations in serum and cerebrospinal fluid (CSF) samples from 8 patients were assayed by high pressure liquid chromatography. It was possible to determine sequential series of ventricular (CSF) and serum concentrations in 4 adult neurosurgical patients with slight to moderate impairment of blood-CSF barriers, because serial CSF samples were obtained from external ventricular drains. In 4 other patients with meningitis, temocillin was given in addition to the regular treatment schedule and 6 'spot' concentrations of temocillin in lumbar CSF and serum samples were determined. Temocillin CSF concentrations in these subjects seemed to be inadequate for the treatment of Gram-positive bacterial meningitis and only partially valuable for the treatment of Gram-negative bacillary meningitis.
D000328:Adult; D001812:Blood-Brain Barrier; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008581:Meningitis / Q000378:metabolism; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism; D010406:Penicillins / Q000097:blood / Q000134:cerebrospinal fluid*; D013345:Subarachnoid Hemorrhage / Q000378:metabolism
D010406:Penicillins; C031367:temocillin