[Effect of the antiemetic preparation dimetpramid on rat reproductive function].
It has been demonstrated that dimethpramide exerted an adverse effect on the sexual glands of female rats. It provoked an inhibition of ovarian function (derangement of cycling rhythmicity, the loss of individual cycle stages) and depletion of energy resources of the uterus (drop of glycogen content). The reduction of the gonadotropic activity of the pituitary was also observed.
D000284:Administration, Oral; D000818:Animals; D000932:Antiemetics / Q000633:toxicity*; D001549:Benzamides / Q000633:toxicity*; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D010053:Ovary / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D000932:Antiemetics; D001549:Benzamides; C037141:dimetpramid
Vliianie protivorvotnogo preparata dimetpramida na reproduktivnuiu funktsiiu krys.