title: Effects of atropine, acepromazine, meperidine, and xylazine on gastroesophageal sphincter pressure in the dog.
abstract: Gastroesophageal sphincter (GES) pressure was 47.9 +/- 1.2 mm of Hg in nontreated dogs. Treatment with atropine, acepromazine, and xylazine reduced GES pressure to 13.2 +/- 2.03, 18.6 +/- 2.14, and 11.7 +/- 1.19 mm of Hg, respectively. Treatment with meperidine resulted in phasic contractions with minimum and maximum pressures of 27.9 +/- 4.55 and 98.9 +/- 9.16 mm of Hg, respectively. Drugs used in anesthetic procedures can reduce GES pressure in dogs.
mesh_terms: D000075:Acepromazine / Q000494:pharmacology*; D000768:Anesthesia, General / Q000662:veterinary*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D004943:Esophagogastric Junction / Q000187:drug effects* / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects; D008614:Meperidine / Q000494:pharmacology*; D011312:Pressure; D013270:Stomach / Q000502:physiology; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
chemical_list: D013843:Thiazines; D014991:Xylazine; D000075:Acepromazine; D001285:Atropine; D008614:Meperidine