The role of dopamine in the formation of gastric ulcers in rats.
A single dose of the dopamine agonists L-dopa, bromocriptine or apomorphine produced a protective effect by significantly shortening of the length of stomach ulcerations. A single dose of the dopamine antagonists haloperidol, sulpiride or domperidone potentiated the ulcerogenic effect by extending the length of stomach ulcerations. These results point to the fact that dopamine is involved in the rise and development of experimental stomach ulcers.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D004294:Domperidone / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000503:physiopathology*; D013469:Sulpiride / Q000494:pharmacology
D001971:Bromocriptine; D007980:Levodopa; D004294:Domperidone; D013469:Sulpiride; D006220:Haloperidol; D001058:Apomorphine; D004298:Dopamine