[Polyneuropathy after cisplatin treatment].
Polyneuropathy developed in 7 of 87 women who had been treated with cis-platinum for ovarian carcinoma. Distal disturbances of sensitivity were clinically prominent, the emphasis being on disturbed vibratory perception and acrognosis. No relevant signs of motor dysfunction were noticed, neither clinically nor neurophysiologically. Sural biopsies taken from two women revealed a primary axonal degeneration, mostly affecting the myelinic fibres of large diameter. In 3 cases mild reversion was seen, and in 4 cases no definite reversion, of the disturbed functions - uncertain gait and clumsiness of the hands - during the follow-up period of 6 to 30 months.
D000368:Aged; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000139:chemically induced*; D004576:Electromyography; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009416:Nerve Regeneration; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013497:Sural Nerve / Q000473:pathology / Q000648:ultrastructure
D002945:Cisplatin
Polyneuropathie nach Cisplatin-Behandlung.