[Resistance to the inhibitory effect of dexamethasone in brain tumor patients].
Out of 24 patients with brain tumors, 22 proved to be resistant to inhibition by dexamethasone. There were no significant differences in the sensitivity to dexamethasone in three study groups established on the basis of the tumor site-to-diencephalic structures distance. A relatively higher frequency of disturbances in dexamethasone inhibition in patients with brain tumors suggests grave disorders induced in glucocorticoid secretion regulation by chronic stress.
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000503:physiopathology*; D003397:Craniopharyngioma / Q000503:physiopathology; D003907:Dexamethasone / Q000037:antagonists & inhibitors*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D008297:Male; D008577:Meningeal Neoplasms / Q000503:physiopathology; D008579:Meningioma / Q000503:physiopathology; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000187:drug effects
D003907:Dexamethasone
Rezistentnost' k ingibiruiushchemu éffektu deksametazona u bol'nykh s opukholiami golovnogo mozga.