title: A drug used in traditional medicine: Harpagophytum procumbens DC. III. Effects on hyperkinetic ventricular arrhythmias by reperfusion.
abstract: In Langendorff preparations of rat heart, hyperkinetic ventricular arrhythmias (HVA) have been induced by an ischaemic perfusion (coronary flux 0.5 ml/min; pressure 8 mmHg) and following reperfusion at basal conditions (coronary flux 8 ml/min; pressure 50 mmHg). Crude methanolic extracts of Harpagophytum procumbens secondary roots and harpagoside showed a significant, dose-dependent, protective action toward HVA induced by reperfusion.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D003326:Coronary Circulation / Q000187:drug effects; D004562:Electrocardiography; D006027:Glycosides; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D009203:Myocardial Infarction / Q000503:physiopathology; D010477:Perfusion; D010936:Plant Extracts / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D006027:Glycosides; D010936:Plant Extracts; D011714:Pyrans; C033249:harpagoside