Bone metabolism in acute parathyroid crisis.
Studies on bone metabolism described in a fatal case of acute parathyroid crisis, occurring in a 48-year-old woman in whom serum immunoreactive parathyroid hormone levels were very high, and a 5 g parathyroid adenoma was found at operation. The histological and biochemical findings suggested a massive and acute increase in bone resorption. There was, however, no evidence of any compensatory increase in bone formation, indicating that acute parathyroid crisis is characterized by a marked dissociation between bone resorption and formation. It is suggested that a sudden fall in oestrogen levels may contribute to the pathogenesis of this disorder.
D000208:Acute Disease; D000236:Adenoma / Q000150:complications / Q000378:metabolism; D001862:Bone Resorption / Q000378:metabolism* / Q000473:pathology; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications / Q000378:metabolism; D008875:Middle Aged; D010279:Parathyroid Diseases / Q000150:complications / Q000378:metabolism*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000378:metabolism