Preparation, quality control and application of 99mTc-gluco-ene-diolate for renal scanning.
A one-step freeze-dried Sn-glucose kit was developed to be labelled with technetium-99m. TLC, paper chromatography and gel chromatography column scanning techniques (GCS) were used for the determination of the labelling yield of the complex. High radiochemical purity was obtained (98%). In vivo distribution studies were performed in white rats. Maximum uptake in kidneys (28%) was achieved in 15-90 min. The blood disappearance curve studies of the labelled Sn(II)-gluco-ene-diolate in rabbits have shown two disappearance phases of activity from blood with biological half-times of 10 and 150 min for the fast and slow component respectively.
D000818:Animals; D005942:Gluconates / Q000138:chemical synthesis* / Q000378:metabolism; D007668:Kidney / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000138:chemical synthesis* / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D005942:Gluconates; D015609:Organotechnetium Compounds; C035148:technetium Tc 99m tin gluconate; D013667:Technetium