title: [Comparative effects of magnesium deficiency and overload on calcium and phosphorus metabolism in the growing pig].
abstract: This study was designed to assess the influence of dietary magnesium on calcium and phosphorus metabolism in growing pigs. 18 4-month-old pigs received either an Mg-deficient (40 ppm), an Mg overload (5,600 ppm) or a control Mg diet (1,000 ppm) for 70 days. The following parameters were measured: kinetics of plasma concentrations of Ca, phosphates, Mg and alkaline phosphatase (AP), absorptions, urinary and fecal excretions, retentions of Ca, P and Mg, soft tissue and bone mineral contents (BMC), and intestinal mucosal CaBP (calcium-binding protein) and AP activities. Dietary Mg level had no effect on calcium and phosphorus metabolism as far as Ca and P absorptions and retentions, BMC, intestinal CaBP and plasma levels of Ca, P and AP are concerned. Mg overload significantly decreased urinary P excretion and increased kidney P content, but did not change fecal P excretion. Jejunal AP activity was slightly decreased in Mg-deficient pigs. The plasma, bone, urinary, fecal, absorbed and retained Mg varied linearly with Mg intake (r: 0,85-0.96). In Mg-deficient pigs, hypomagnesemia appeared after 1 week and its severity did not increase with time. In Mg-overloaded pigs, hypermagnesemia occurred very late and was limited. This suggests that, in the growing pig, dietary Mg has little or no effect on Ca-P metabolism. It may also be concluded that growing pigs are rather resistant to Mg deficiency since no clinical symptoms were observed.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000032:analysis; D004032:Diet; D005243:Feces / Q000032:analysis; D005260:Female; D007413:Intestinal Mucosa / Q000032:analysis; D007700:Kinetics; D008274:Magnesium / Q000502:physiology*; D008297:Male; D010758:Phosphorus / Q000378:metabolism*; D013552:Swine / Q000254:growth & development*
chemical_list: D002135:Calcium-Binding Proteins; D010758:Phosphorus; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium
vernacular_title: Effets comparés de la carence et de l'excès de magnésium sur le métabolisme phosphocalcique chez le porc en croissance.