Effect of ascorbic and dehydroascorbic acid on glyoxalase enzyme system.
The authors studied the effect of ascorbic and dehydroascorbic acid on glyoxalase enzyme system, in order to establish if these substances influence cell proliferation by interfering with glyoxalase activity. The results demonstrate that both ascorbic and dehydroascorbic acid do not alter glyoxalase activity in vitro, even if employed at high doses.
D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology; D002417:Cattle; D003683:Dehydroascorbic Acid / Q000494:pharmacology*; D007700:Kinetics; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008190:Lyases / Q000378:metabolism*; D051381:Rats; D012440:Saccharomyces / Q000201:enzymology; D013869:Thiolester Hydrolases / Q000378:metabolism*; D000099301:Hydroxyacylglutathione Hydrolase
D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid; D007791:Lactoylglutathione Lyase; D008190:Lyases; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase