[Elimination of disorders of the elasticity and contractile function of nonischemic portions of the heart in myocardial infarct by using glucose and uridine].
A study of an isolated auricle showed that one day after the infarction the extensibility of the atrial myocardium was reduced, the Starling curve was depressed to result in about a two-fold decrease of the peak systolic tension, and atrial myocardial resistance to hypoxia and excessive calcium was also decreased. This complex of shifts was considerably diminished or eliminated altogether by means of building up an excessive glucose concentration or the administration of uridine, a cofactor of glycogen resynthesis. Therefore, the data obtained suggest that uridine can be used for correcting contractile disturbances of nonischemic compartments of the heart in myocardial infarction.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004548:Elasticity; D005947:Glucose / Q000627:therapeutic use*; D006019:Glycolysis / Q000187:drug effects; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014529:Uridine / Q000627:therapeutic use*
D005947:Glucose; D014529:Uridine
Ustranenie narusheniĭ rastiazhimosti i sokratitel'noĭ funktsii neishemizirovannykh otdelov serdtsa pri infarkte miokarda s pomoshch'iu gliukozy i uridina.