Bromoergocryptine decreases serum prolactin and delays sexual maturation in male golden hamsters.
The role of prolactin during sexual maturation in male golden hamsters was studied. Controls (n = 23) received vehicle and treated animals (n = 23) received 500 micrograms 2-bromo-alpha-ergocryptine (CB154) daily from 10 days of age until 4 or 5 wk of age. Serum prolactin in prepubertal male hamsters was reduced to a nondetectable level by treatment with the dopamine agonist CB154. Flank gland diameter, body weight, testicular and total accessory sex organ weights, and serum testosterone were all significantly lower (P less than 0.05) in the CB154-treated animals. In addition, seminiferous tubule area, seminiferous tubule luminal and cellular areas, and number of late spermatids per tubule cross-section were significantly reduced (P less than 0.01) in CB154-treated prepubertal males. Thus, the absence of prolactin retarded sexual maturation in male golden hamsters. These data suggest, that prolactin enhances testosterone production during the process of sexual maturation and supports the development of androgen-dependent tissues.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology*; D006224:Cricetinae; D005837:Genitalia, Male / Q000033:anatomy & histology; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000097:blood*; D012671:Seminiferous Tubules / Q000033:anatomy & histology; D012741:Sexual Maturation / Q000187:drug effects*; D013076:Sperm Count; D013087:Spermatids / Q000166:cytology; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood
D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin