Myocardial recovery after hypothermic arrest: a comparison of oxygenated crystalloid to blood cardioplegia. The role of calcium.
We compared multidose crystalloid hyperkalemic cardioplegic solutions with and without added red cells in 24 canine hearts subjected to 5 hr of arrest at 10 degrees C. All cardioplegic solutions were fully oxygenated at 4 degrees C before delivery. Since blood cardioplegia contained Ca++ carried over with the red cells, Ca++ was added to the crystalloid solution in one group. The table below shows the hematocrit (HCT) and ionized Ca++ concentrations of the cardioplegic solutions, and coronary arteriovenous oxygen difference during infusion of cardioplegic solution (AVO2) (ml O2/100 ml). Recovery during reperfusion is shown as percent of prearrest left ventricular function (LVF) and prearrest myocardial ATP concentration.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001783:Blood Flow Velocity; D001803:Blood Transfusion; D001834:Body Water / Q000378:metabolism; D002118:Calcium / Q000008:administration & dosage / Q000502:physiology*; D004285:Dogs; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006801:Humans; D006982:Hypertonic Solutions; D008297:Male; D009204:Myocardial Revascularization / Q000379:methods; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D010101:Oxygen Consumption; D011188:Potassium; D017680:Potassium Compounds; D012039:Regional Blood Flow
D006982:Hypertonic Solutions; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D000255:Adenosine Triphosphate; D011188:Potassium; D002118:Calcium