[Effect of an operation on the immunoreactivity indices, their postoperative dynamics and the effect of 3-HAA-antigen on these indices in patients with gastrointestinal tumors].
The following parameters were studied in cases of gastrointestinal tumors: 3-hydroxyanthranilic acid (3-HAA)-antigen in blood serum; antibodies to 3-HAA-antigen; immunoglobulins G, A and M (after Manchini); 3-HAA-antigen effect on blastogenic reaction of lymphocytes; 3-HAA-antigen effect on leucocyte migration; blood serum effect on cells producing antibodies to ram erythrocytes, and levels of T-lymphocytes and their subpopulations. The studies were conducted before operation, 4-6, 7 and more months after operation. Tumor removal as well as tumor recurrences and metastases were shown to have an effect on the first 4 parameters. 3-HAA-antigen stimulated the formation of specific antibodies, suppressed blastogenic reaction of lymphocytes but failed to affect leucocyte migration significantly.
D015095:3-Hydroxyanthranilic Acid / Q000097:blood / Q000276:immunology*; D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis / Q000276:immunology*; D002465:Cell Movement / Q000187:drug effects; D005770:Gastrointestinal Neoplasms / Q000276:immunology* / Q000601:surgery; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008809:Mice, Inbred C3H; D011184:Postoperative Period; D012397:Rosette Formation; D062367:ortho-Aminobenzoates / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D007136:Immunoglobulins; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid
Vliianie operatsii na pokazateli immunoreaktivnosti, ikh dinamiku v posleoperatsionnom periode i deĭstvie 3-OAK-antigena na éti pokazateli u bol'nykh opukholiami zheludochno-kishechnogo trakta.