Metabolism and mutagenicity of aromatic amines by human fetal liver.
Human fetal liver microsomes were found to metabolize the carcinogen 2-acetylaminoflurene (AAF), the major metabolite being the deacetylated product 2-aminofluorene (AF). On the other hand, N-hydroxy-2-acetylaminofluorene (N-OH-AAF), a proximate carcinogenic metabolite, could not be detected. The human fetal liver samples converted AF and N-OH-AAF, but not AAF, to products mutagenic for S. typhimurium TA 98.
D015073:2-Acetylaminofluorene / Q000378:metabolism* / Q000633:toxicity; D000588:Amines / Q000378:metabolism; D001711:Biotransformation; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D011247:Pregnancy
D000588:Amines; D009153:Mutagens; D015073:2-Acetylaminofluorene