Serum concentrations of gentamicin in cats.
Twenty-one adult cats, allotted into 2 groups, were given gentamicin sulfate at dosages of either 5.0 mg/kg of body weight or 2.5 mg/kg as a single IM injection. During a 24-hour period, serum concentrations of gentamicin were measured serially, using a fluorescence immunoassay. The mean peak serum concentration of gentamicin in cats given 5.0 mg/kg was 23.1 micrograms/ml at postinjection hour (PIH) 0.5; thereafter, the mean serum concentration steadily decreased to 2.0 micrograms/ml at PIH 24. The mean peak serum concentration for cats administered 2.5 mg/kg was 9.1 micrograms/ml at PIH 0.5; thereafter, the mean serum concentration steadily decreased to 1.3 micrograms/ml at PIH 12. Serum therapeutic concentrations, without exceeding toxic concentrations, were attained at the 2.5 mg/kg dosage.
D000818:Animals; D002415:Cats / Q000097:blood*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood*; D007118:Immunoassay / Q000379:methods; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D013997:Time Factors
D005839:Gentamicins