title: An in vivo model for pharmacokinetic studies in the kidney.
abstract: In order to assess drug renal kinetics in vivo, the two kidneys of seven ewes were surgically placed under the skin. Through the use of renal function tests and a series of biopsies, we found that the kidneys remained normal in their subcutaneous location. Gentamicin renal kinetics were evaluated in conscious animals by a series of biopsies. Histological controls showed only slight lesions due to biopsy; based upon plasma hydrocortisone concentration, there was no indication of chronic stress affecting the renal pharmacokinetics. We suggest that this model has great potential as a method for studying in vivo the kinetics of drug disposition in the renal tissue and assessing the residue level of a drug.
mesh_terms: D000818:Animals; D005260:Female; D005839:Gentamicins / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012756:Sheep
chemical_list: D005839:Gentamicins; D004364:Pharmaceutical Preparations