Conjugation of disodium 6-chloro-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxy late with glutathione in the rat.
Disodium 6-chloro-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline- 2,8-dicarboxylate (I) is conjugated with glutathione (GSH) both in vitro and in vivo by nucleophilic replacement of the chlorine substituent in (I). The reaction is catalysed by rat-liver supernatant. The GSH conjugate is the principal excretory product in the rat bile after i.v. administration of (I), accounting for approximately 60% of the dose and 95% of the biliary excretion. Its structure was determined by synthesis and spectroscopic analysis.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D011804:Quinolines / Q000378:metabolism*; D015363:Quinolones; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism
D011804:Quinolines; D015363:Quinolones; C046411:6-chloro-4-oxo-10-propyl-4H-pyrano(3,2-g)quinoline -2,8-dicarboxylate; D005978:Glutathione