Possible role for carbamyl phosphate in the control of liver glycogen synthesis.
Isotopic data suggested a possible correlation between the activation of liver glycogen synthesis and some unstable intermediate. Carbamyl phosphate was one candidate considered. L-Norvaline, an inhibitor of ornithine transcarbamylase, is known to increase intracellular carbamyl phosphate levels. L-Norvaline augmented the increase in glycogen synthesis caused by L-glutamine and L-alanine, and also induced considerable glycogen synthesis with ammonia as the nitrogen source.
D000409:Alanine / Q000378:metabolism; D000643:Ammonium Chloride / Q000378:metabolism; D000818:Animals; D002219:Carbamates / Q000502:physiology*; D002221:Carbamyl Phosphate / Q000502:physiology*; D002478:Cells, Cultured; D005973:Glutamine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008112:Liver Glycogen / Q000096:biosynthesis*; D009954:Ornithine Carbamoyltransferase / Q000037:antagonists & inhibitors; D051381:Rats; D014633:Valine / Q000494:pharmacology / Q000031:analogs & derivatives
D002219:Carbamates; D008112:Liver Glycogen; D000643:Ammonium Chloride; D005973:Glutamine; D002221:Carbamyl Phosphate; C005313:norvaline; D009954:Ornithine Carbamoyltransferase; D014633:Valine; D000409:Alanine