Pancreatic function in patients with hyperparathyroidism. A study with the Lundh test.
To elucidate the assumed relationship between hyperparathyroidism and pancreatitis, the pancreatic function was studied in 20 patients with hyperparathyroidism. In all cases removal of a parathyroid adenoma was followed by normalization of preoperative hypercalcemia. A modified Lundh's test with duodenal aspiration was performed before and after the operation. The volume of the aspirate and its content of electrolytes and pancreatic isoamylase were compared with findings in an age-matched control group. Preoperatively the volume of secretion was significantly less in the patients than in the controls. Carbonate levels were also decreased, but changes in enzymatic activity were slight. Postoperatively there was significant increase in aspirate volume and fall in the level of duodenal calcium. The results suggested an influence of hyperparathyroidism on exocrine pancreatic function, even when no symptoms of pancreatic disease are present.
D000236:Adenoma / Q000150:complications / Q000601:surgery; D000328:Adult; D000368:Aged; D004386:Duodenum / Q000378:metabolism; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D006961:Hyperparathyroidism / Q000209:etiology / Q000503:physiopathology*; D007517:Isoamylase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology / Q000378:metabolism*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000601:surgery
D007517:Isoamylase