Possible mechanisms of hydrocarbon-associated glomerulonephritis.
Many hydrocarbons have properties which make them candidates for causing glomerulonephritis. They alter most immune functions and create a state of immunity deficiency; they damage the tubules which may lead to interstitial fibrosis and increased postglomerular capillary resistance furthering the trapping of macromolecules in the glomeruli; and they probably increase tissue permeability to macromolecules. The idea that hydrocarbons cause glomerulonephritis is supported by findings of an association between glomerulonephritis and hydrocarbon exposure, by findings of a relationship between tubulointerstitial damage and glomerular filtration rate in glomerulonephritis, and by findings of immunity deficiency in most subgroups of glomerulonephritis.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects* / Q000506:poisoning / Q000633:toxicity; D007109:Immunity / Q000187:drug effects; D007121:Immunocompetence / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects; D051379:Mice; D009784:Occupational Diseases / Q000139:chemically induced*; D011817:Rabbits; D051381:Rats
D006838:Hydrocarbons