title: Prostaglandin F and E levels in the conceptus, uterus and plasma during early pregnancy in the ewe.
abstract: Concentrations of prostaglandins E and F (PGE and PGF) were measured in the embryo or fetus, extra embryonic or fetal membranes (membranes), intercaruncular and caruncular endometrium and plasma collected from uterine and ovarian arterial and venous vessels from separate groups of ewes laparotomized at 5 day intervals from day 10 to day 55 of pregnancy. Our purpose was to investigate the role of prostaglandins E and F in the maternal recognition of pregnancy, implantation and early placental function. Our data suggest that the initial maintenance of the corpus luteum in the pregnant ewe does not involve a reduction in PGF production, compared to pregnant ewes; but a change in the pattern of PGF secretion. This is accompanied by an elevation in PGE production of similar magnitude to that observed in non pregnant ewes. The extra embryonic/fetal membranes appear to be the major source of elevated PGF levels in the maternal circulation prior to day 30 of pregnancy. Between days 35 and 55 of gestation the rising PGF levels in maternal serum probably come from the fetus. Over the same period PGE levels rise in the fetus and intercaruncular endometrium, but PGE secretion into the maternal circulation is not enhanced. A role for PGF and PGE in fetal, placental and uterine growth is suggested; placental and uterine endocrine function may also be targets.
mesh_terms: D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011458:Prostaglandins E / Q000097:blood / Q000378:metabolism*; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism*; D012756:Sheep; D014599:Uterus / Q000378:metabolism*
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F