The effects of short-term administration of ibuprofen on trimethadione metabolism and antipyrine metabolite formation in the rat.
In this study, trimethadione (TMO) was chosen as a model drug to investigate the extent of hepatic drug-oxidizing capacity. It was also studied whether pretreatment of rats with ibuprofen selectively affected the formation of antipyrine metabolites. The ratios of serum dimethadione (DMO)/TMO and the urinary metabolite formation of antipyrine in the rat pretreated with ibuprofen 50 mg/kg daily for 7 days were not changed as compared to controls. These results indicate that the short-term administration of ibuprofen did not impair TMO metabolism and changed antipyrine and its metabolite formation in the rat 24 h urine.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D007052:Ibuprofen / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D010080:Oxazoles / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014293:Trimethadione / Q000378:metabolism*
D010080:Oxazoles; D008748:Methylcholanthrene; D014293:Trimethadione; D000983:Antipyrine; D007052:Ibuprofen; D010634:Phenobarbital