Determination of desferoxamine and a major metabolite by high-performance liquid chromatography. Application to the treatment of aluminium-related disorders.
A high-performance liquid chromatography method is described that permits separation and quantification of desferoxamine, a major metabolite, the iron(III) and the aluminum(III) chelates of desferoxamine. This method now facilitates pharmacokinetic studies on desferoxamine and derivatives designed to study side-effects and metabolite patterns in patients undergoing treatment.
D000535:Aluminum / Q000097:blood / Q000506:poisoning*; D000544:Alzheimer Disease / Q000097:blood; D002614:Chelating Agents / Q000097:blood / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D003676:Deferoxamine / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D005260:Female; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D013056:Spectrophotometry, Ultraviolet
D002614:Chelating Agents; D000535:Aluminum; D003676:Deferoxamine