The effect of isoprenaline on the ciliary activity of an in vitro preparation of rat trachea.
A dose dependent increase in the ciliary beat frequency of rat tracheal explants was found over a 10(-7)-10(-3) M concentration range of (+/-)-isoprenaline and was abolished by 10(-7) M propranolol. Furthermore (+)-isoprenaline, a drug which is much less potent in its action on beta-adrenoceptors than its (-)-isomer, failed to cause a stimulation. We conclude that the acceleration in the intrinsic ciliary beat frequency by (-)-isoprenaline, although occurring at a relatively high concentration compared with the action of the drug on other tissues, is mediated by beta-adrenoceptors.
D000818:Animals; D002923:Cilia / Q000187:drug effects; D066298:In Vitro Techniques; D007536:Isomerism; D007545:Isoproterenol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014132:Trachea / Q000187:drug effects*; D014783:Viscosity
D011433:Propranolol; D007545:Isoproterenol