New antitumor antibiotics, FR-900405 and FR-900406. II. Production, isolation, characterization and antitumor activity.
The new antitumor antibiotics, FR-900405 and FR-900406, were isolated from the culture broth of Actinomadura pulveracea sp. nov. No. 6049. These compounds which contain sulfur in the molecule, represent a novel class of antitumor agents. FR-900405 and FR-900406 are highly active in mice against experimental tumors and exhibit antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi.
D000192:Actinomycetales / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D062367:ortho-Aminobenzoates / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D062367:ortho-Aminobenzoates; C046601:FR 900406; C046600:FR 900405