Effects of elevation of serum cholesterol and administration of amphotericin B complexed to lipoproteins on amphotericin B-induced toxicity in rabbits.
Amphotericin B was infused into normal rabbits or rabbits made hypercholesterolemic by diet. There was no difference in amphotericin B-induced toxicity between these two groups. Amphotericin B given in a mixture with human low-density lipoproteins was more toxic than when given without lipoproteins.
D000666:Amphotericin B / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003401:Creatine / Q000097:blood; D003404:Creatinine / Q000097:blood; D004032:Diet; D006937:Hypercholesterolemia / Q000503:physiopathology; D008074:Lipoproteins / Q000008:administration & dosage*; D011817:Rabbits
D008074:Lipoproteins; D000666:Amphotericin B; D002784:Cholesterol; D003404:Creatinine; D003401:Creatine