Suppression of an ethanol withdrawal syndrome in rats by 3-hydroxybutyrate.
An ethanol withdrawal syndrome was elicited by withholding ethanol from physically dependent, male Sprague-Dawley rats. Ethanol dependence had been induced by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a four-day period. Oral administration of 3-hydroxybutyrate, a compound which is elevated in blood of ethanol dependent rats and is a substrate of both the cerebral small-pool and large-pool Krebs-cycle, was effective in suppressing the tremulous component of the ethanol withdrawal syndrome. 3-Hydroxybutyrate did not function as a central nervous system depressant at the dose levels employed.
D020155:3-Hydroxybutyric Acid; D000284:Administration, Oral; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy*; D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007773:Lactates / Q000627:therapeutic use; D019344:Lactic Acid; D008297:Male; D011604:Psychoses, Alcoholic / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D006885:Hydroxybutyrates; D007773:Lactates; D019344:Lactic Acid; D000431:Ethanol; D020155:3-Hydroxybutyric Acid