Influence of antioxidants and radical scavengers on ethanol-induced gastric ulcers in the rat.
Sodium benzoate in doses which do not possess antisecretory properties, produced a dose-dependent reduction of ethanol-induced gastric lesions in the rat. Indomethacin pretreatment antagonized sodium benzoate-ulcer reducing properties indicating that this latter acts, at least in part, through stimulation of prostaglandins synthesis. Propyl gallate reduced ethanol-induced gastric lesions in doses which exert antisecretory properties.
D000818:Animals; D000897:Anti-Ulcer Agents; D000975:Antioxidants / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D002927:Cimetidine / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D005609:Free Radicals; D005753:Gastric Mucosa / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D011435:Propyl Gallate / Q000494:pharmacology; D011448:Prostaglandin Antagonists; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D000975:Antioxidants; D001565:Benzoates; D005609:Free Radicals; D011448:Prostaglandin Antagonists; D000431:Ethanol; D002927:Cimetidine; D011435:Propyl Gallate; D019817:Benzoic Acid; D007213:Indomethacin