Studies of marginal zinc deprivation in rhesus monkeys: VI. Influence on the immunohematology of infants in the first year.
Rhesus monkey infants fed a marginally zinc-deficient diet (4 ppm) from conception through 12 mo of postnatal life were monitored for changes in hematological, biochemical, and immunological parameters. These zinc-deprived (ZD) infants were compared to control infants whose mothers were fed a zinc-replete (100 ppm) diet either ad libitum (AL) or pair-fed (PF) throughout gestation and lactation. Blast transformation of peripheral blood lymphocytes to phytohemagglutinin (PHA-P), concanavalin A (Con A), and pokeweed mitogen (PWM), was dramatically depressed in the zinc-deficient (ZD) group. Similarly, ZD infants had reduced polymorphonuclear leukocyte function as measured by chemotaxis to endotoxin-activated plasma and phagocytosis of Candida albicans. Levels of serum IgM were significantly altered in zinc-deficient infants compared to controls. Serum concentrations of IgG and IgA were similar in zinc-deficient and control infants. ZD infants also manifested a hypochromic microcytic anemia at one month of age, reduced activity of the zinc metalloenzyme alkaline phosphatase, and lower activity of SGPT.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D003300:Copper / Q000097:blood; D003602:Cytotoxicity, Immunologic; D004573:Electrolytes / Q000097:blood; D004909:Erythrocyte Indices; D005260:Female; D007075:Immunoglobulin M / Q000097:blood; D007501:Iron / Q000097:blood; D008213:Lymphocyte Activation; D008253:Macaca mulatta; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D015032:Zinc / Q000097:blood / Q000172:deficiency*
D004573:Electrolytes; D007075:Immunoglobulin M; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D003300:Copper; D007501:Iron; D000469:Alkaline Phosphatase; D015032:Zinc