A quantitative morphological study of the effects of carbenoxolone sodium on duodenal goblet-cells of the rat.
A direct microscopic and microdensitometric examination was carried out on duodenal goblet-cells of non-fasted and fasted rats with and without carbenoxolone sodium treatment. The results of microdensitometric examination revealed a marked and significant increase of mucus production in the non-fasted and fasted rats pretreated for 2 hr with a single oral dose of carbenoxolone sodium at 100 mg/kg. Fasting alone also increased mucus production. On microscopic examination, the number of duodenal goblet-cells full of mucosubstances in the non-fasted and fasted rats receiving carbenoxolone sodium treatment was approximately 20% higher than in the controls.
D000818:Animals; D002229:Carbenoxolone / Q000494:pharmacology*; D003720:Densitometry; D004386:Duodenum / Q000166:cytology; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives*; D007413:Intestinal Mucosa / Q000166:cytology* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002229:Carbenoxolone; D006034:Glycyrrhetinic Acid