Monovalent cations transfer through isolated human amnion: a new pharmacological model.
Transfer of monovalent cation through the isolated human amnion consists of different factors: paracellular, coupling, ATPase dependent cellular transfer, leak cellular transfer. Understanding this transfer permits testing of the action of various substances. Physiological substances (Mg, taurine) increase ionic transfer and there is a vicarious effect between Mg and taurine. The tocolytic agents MgSO4 and ethanol do not exhibit a good effect on the transfer: decrease with ethanol; equality between entry and exit fluxes with MgSO4. On the other hand, amphotericin B increases mother-to-fetus transfer. Polluting metals (Pb, Cd, Hg, As) dramatically reduce exchanges and almost completely inhibit amnion permeability. Ingestion of ethanol also exhibits a dramatic effect on the exchange between mother and fetus through the amnion. Study of ionic transfer in vitro can be considered a pharmacological model to investigate the modifications of mother-fetus exchanges by various substances.
D000650:Amnion / Q000502:physiology*; D000666:Amphotericin B / Q000494:pharmacology; D001692:Biological Transport / Q000187:drug effects; D002414:Cations, Monovalent / Q000378:metabolism; D004553:Electric Conductivity; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials; D008954:Models, Biological; D011247:Pregnancy; D013654:Taurine / Q000494:pharmacology; D014874:Water Pollutants, Chemical / Q000494:pharmacology
D002414:Cations, Monovalent; D014874:Water Pollutants, Chemical; D013654:Taurine; D000431:Ethanol; D000666:Amphotericin B; D008274:Magnesium