[Combined use of metronidazole and short-term hyperglycemia during radiation therapy of tumors in rats].
A simultaneous combined treatment with metronidazole and short-term hyperglycaemia, in contrast to application of each of these agents alone, enhanced considerably the therapeutic effect of radiation (a single and fractionated exposure). This was indicated by the increased rate of tumor regression, the number of animals with transient remission, and the number of cured animals which exhibited no relapse throughout the entire 90-day period of observation.
D000818:Animals; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005720:Gamma Rays / Q000627:therapeutic use; D005947:Glucose / Q000008:administration & dosage*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D009368:Neoplasm Transplantation; D011837:Radiation-Protective Agents; D011879:Radiotherapy Dosage; D051381:Rats; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D013997:Time Factors
D011837:Radiation-Protective Agents; D008795:Metronidazole; D005947:Glucose
Kombinirovannoe primenenie metronidazola i kratkovremennoĭ giperglikemii pri luchevoĭ terapii opukholeĭ krys.