Differential binding of glycine- and taurine-conjugated bile acids to insoluble calcium phosphate.
It is demonstrated that bile acids bind to insoluble calcium phosphate at pH values beyond 5.5. Significant binding occurs with glycine-conjugated dihydroxy bile acids. Results indicate that these bile acids are bound in a micellar mode. Taurine conjugation almost completely inhibits the binding of these bile acids to insoluble calcium phosphate. Since glycine-conjugated dihydroxy bile acids are predominant in the rabbit, but not in the rat, our results suggest an explanation for the intriguing species-dependence of casein-induced hypercholesterolaemia, which is high in the rabbit but absent in the rat.
D001647:Bile Acids and Salts / Q000378:metabolism*; D002130:Calcium Phosphates / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D006002:Glycodeoxycholic Acid / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D013654:Taurine / Q000378:metabolism
D001647:Bile Acids and Salts; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D013654:Taurine; D006002:Glycodeoxycholic Acid; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; D005998:Glycine