[Midantan activation of memory trace retrieval in rats].
The authors studied the action of amantadine in recovery processes of the memory in some types of retrieval impairment: normal forgetting, "psychogenous" amnesia and latent inhibition. Antraperitoneal injection of amantadine (25 mg/kg) to rats I h before testing the preservation of the conditioned passive avoidance reaction was discovered to restore the conditioned reaction which went out as a result of long-term preservation. To restore the memory in amnesia and latent inhibition, 50 mg/kg amantadine was required. Thus, it has been shown that amantadine has reactivating properties in memory processes.
D000547:Amantadine / Q000494:pharmacology* / Q000627:therapeutic use; D000647:Amnesia / Q000188:drug therapy; D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004924:Escape Reaction / Q000187:drug effects; D007266:Inhibition, Psychological; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000547:Amantadine
Aktivatsiia midantanom vosproizvedeniia sleda pamiati u krys.