[Cytochemical study of lymphocyte nucleoproteins in rheumatoid arthritis patients].
The purpose of the study is to investigate and juxtapose the cytochemical characteristics of ribonucleoproteins (RNP) and deoxyribonucleoproteins (DNP) in the lymphocytes of patients with rheumatoid arthritis (RA), of healthy lymphocytes and lymphocytes blast-transformed by phytohemagglutinins. Significant differences in the staining of lymphocytes for nucleoproteins were established in all 54 patients with RA studied. The unidirectional changes in the morphological form of the staining for RNP and DNP in blast-transformed lymphocytes and lymphocytes in RA is, most likely, in connection with the transition of the latter into active functional state and their participation in the forming of the immune inflammation. No significant difference was established in the dependence on the RA form--sero-positive or sero-negative. Regardless of the negative serological samples in the second form, there were some changes in the lymphocytes--carriers of immune reactions in organism.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood*; D003852:Deoxyribonucleoproteins / Q000097:blood; D006651:Histocytochemistry; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D009698:Nucleoproteins / Q000097:blood*; D010835:Phytohemagglutinins / Q000494:pharmacology; D012261:Ribonucleoproteins / Q000097:blood
D003852:Deoxyribonucleoproteins; D009698:Nucleoproteins; D010835:Phytohemagglutinins; D012261:Ribonucleoproteins
Tsitokhimichno izsledvane na nukleoproteini v limfotsitite na bolni s revmatoiden artrit.