5-Fluoroorotate: a new liposome-dependent cytotoxic agent.
The potency of 5-fluoroorotate for inhibition of L929 or CV1-P cell growth is increased by encapsulation in negatively charged liposomes. The optimal liposome composition is dipalmitoylphosphatidylglycerol: cholesterol, 67:33. Unextruded large unilamellar liposomes are the optimal size for delivery. This compound is the second transport-negative drug which we have found to exhibit liposome-dependent delivery.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D008081:Liposomes; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D000970:Antineoplastic Agents; D008081:Liposomes; D009963:Orotic Acid; C001242:5-fluoroorotic acid