title: Aversive effects of vagotomy in the rat: a conditioned taste aversion analysis.
abstract: Subdiaphragmatic vagotomy suppresses food intake and water intake in normal rats. Since human patients report some nausea and discomfort following vagotomy, the present study assessed the aversive consequences of vagotomy in rats using a conditioned taste aversion paradigm. Rats were given a total subdiaphragmatic vagotomy or sham vagotomy, and were then maintained on either plain water (Vag-Water and Sham-Water groups) or a novel cherry solution (Vag-Cherry and Sham-Cherry groups). When subsequently tested for their water vs. cherry preferences on postoperative days 6, 16, and 26, the Vag-Cherry group displayed a greater aversion to the cherry solution than did the remaining three groups. This result suggests that vagotomy produces visceral malaise in rats which may contribute to the feeding and drinking suppressive effects of the surgery.
mesh_terms: D000818:Animals; D000855:Anorexia / Q000503:physiopathology; D001362:Avoidance Learning / Q000502:physiology*; D004327:Drinking Behavior / Q000502:physiology; D005260:Female; D007082:Ileum / Q000601:surgery; D007583:Jejunum / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000502:physiology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology