[The effects of hepatic ischemia on systemic blood coagulation and fibrinolysis in mongrel dogs].
In order to elucidate the effects of hepatic ischemia on systemic blood coagulation and fibrinolysis, experimental study was performed. Under the heparinized hydrophilic catheter-bypass between splenic and femoral vein, the hepato-duodenal and hepato-gastric ligaments were ligated to interrupt hepatic blood inflow in 5 dogs, and temporary interruption of hepatic blood inflow for 15, 30, 60, 90 minutes were performed in each 5 dogs. In this experimental study, changes of systemic blood coagulation and fibrinolysis, and histological changes of the liver were investigated periodically. Continuous interruption of hepatic blood inflow decreased blood coagulability gradually. Temporary interruption of hepatic blood inflow for more than 60 minutes caused remarkable decrease of blood coagulability after declamp, and histologically fibrin deposits were found in sinusoid and portal vein of Glisson's area, indicating that apparent DIC occurred in the liver at more than 60 minutes after clamp. One hour after declamp of 90 minutes interruption of hepatic blood inflow, most of fibrin deposits disappeared but severe degeneration of endothelial cell of sinusoid and hepatocyte were observed, indicating the disturbance of hepatic microcirculation which caused acute liver failure and systemic DIC, finally death in shock.
D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D004285:Dogs; D005342:Fibrinolysis; D005343:Fibrinolytic Agents / Q000032:analysis; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000150:complications; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D012039:Regional Blood Flow
D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents