Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes.
The degree of diabetic osteopenia and serum vitamin D metabolite levels were measured in 168 type 2 (noninsulin-dependent) diabetic patients. Based on six indices obtained by microdensitometry, we found the bone mass in 26.2% of diabetic patients to be clearly decreased and in 11.9% to be severely decreased. Our direct method of analysis of bone mass shows that diabetic osteopenia differs from typical osteoporosis in character. In addition, serum 24,25-dihydroxyvitamin D was significantly decreased (P less than 0.01), but 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were similar to those of controls.
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002112:Calcifediol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000628:therapy; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D008297:Male; D008832:Microchemistry; D008875:Middle Aged; D014807:Vitamin D / Q000097:blood*
D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002112:Calcifediol