Concentrations of mezlocillin in the serum, heart valves, muscle and subcutaneous tissue of patients undergoing open-heart surgery.
4 g mezlocillin as a five-minute intravenous bolus were given preoperatively to 31 adult patients undergoing open-heart surgery. Mezlocillin serum levels declined from 42.8 mg/l at 1-2 h after injection to less than 1 mg/l at 6-8 h after application. Concentrations in muscle and subcutaneous tissue varied between 18 micrograms/g and less than 1 microgram/g. Mezlocillin levels in heart valves were higher than those in muscle and subcutaneous tissue, thus suggesting rapid diffusion of mezlocillin.
D000273:Adipose Tissue / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000378:metabolism / Q000601:surgery*; D006351:Heart Valves / Q000378:metabolism*; D006801:Humans; D008297:Male; D008802:Mezlocillin / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011292:Premedication; D014018:Tissue Distribution
D008802:Mezlocillin