The influence of a new low molecular weight sulphated polysaccharide from mussel broth (Org 30016) on haemostasis.
The effect on haemostasis of a new low molecular weight sulphated polysaccharide (4300 dalton) from mussel broth (Org 30016) was investigated. In an APT time test system it had an anticoagulant effect corresponding to 30-40% of that of heparin. It had no antithrombin effect. It exerted its effect only in test systems containing phospholipids. It did not prolong haemostatic plug formation time in the rabbit mesenteric microcirculation as did heparin. Formation of ex vivo Chandler thrombi was significantly inhibited. The practical interest of the substance comes from the combination of an antithrombotic effect and little influence on primary haemostasis.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D049872:Bivalvia; D002196:Capillaries; D004305:Dose-Response Relationship, Drug; D005170:Factor X / Q000096:biosynthesis; D015951:Factor Xa; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D010314:Partial Thromboplastin Time; D011134:Polysaccharides / Q000494:pharmacology; D013918:Thrombin Time; D013927:Thrombosis / Q000139:chemically induced
D000925:Anticoagulants; C045769:Org 30016; D011134:Polysaccharides; C033762:S-Lim; D005170:Factor X; D006493:Heparin; D015951:Factor Xa