Etomidate infusion and adrenocortical function. A study in elective surgery.
The adrenocortical response to a short tetracosactrin (Synacthen) test was studied in 11 patients receiving either etomidate infusion or thiopentone infusion used to maintain anaesthesia for abdominal hysterectomy. Pethidine was used as the narcotic component. The results showed that etomidate infusion (median 28.5 ug/kg/min) completely blocked the adrenocortical response to corticotropin stimulation for at least 24 h after surgery. No suppression was found in patients receiving thiopentone infusion. It is concluded that etomidate cannot be recommended for routine induction and maintenance of anaesthesia.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000309:Adrenal Insufficiency / Q000139:chemically induced*; D000777:Anesthetics / Q000009:adverse effects / Q000494:pharmacology*; D003366:Cosyntropin / Q000494:pharmacology; D004361:Drug Tolerance; D005045:Etomidate / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007044:Hysterectomy; D007093:Imidazoles / Q000494:pharmacology*; D011183:Postoperative Complications / Q000139:chemically induced; D013874:Thiopental
D000777:Anesthetics; D007093:Imidazoles; D003366:Cosyntropin; D013874:Thiopental; D005283:Fentanyl; D006854:Hydrocortisone; D005045:Etomidate