Effect of 2-deoxyglucose, alpha-methylglucoside, and glucosamine on aflatoxin production by Aspergillus parasiticus.
The effects of 2-deoxyglucose (2-DOG), alpha-methylglucoside (alpha-MG), and glucosamine (GA) on aflatoxin production by Aspergillus parasiticus were studied using conidia-initiated and replacement cultures. In conidia-initiated, 2-DOG, alpha-MG, and GA supported varying amounts of growth when employed as sole carbon sources. In both conidia-initiated and replacement cultures, 2-DOG, but not alpha-MG nor GA, as sole carbon sources support toxin formation. None of the compounds inhibited aflatoxin production when used in combination with glucose. It appears that neither 2-DOG, alpha-MG, nor GA can be considered nonmetabolizable analogs of glucose in A. parasiticus.
D000348:Aflatoxins / Q000096:biosynthesis*; D001230:Aspergillus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism / Q000494:pharmacology; D005944:Glucosamine / Q000378:metabolism / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D008757:Methylglucosides / Q000378:metabolism / Q000494:pharmacology
D000348:Aflatoxins; D008757:Methylglucosides; C027020:methylglucoside; D003847:Deoxyglucose; D005947:Glucose; D005944:Glucosamine