title: Effects of monensin on monovalent ion metabolism and tissue concentrations in lambs.
abstract: A study consisting of two trials was conducted to determine the effects of monensin on the apparent absorption and retention of sodium (Na) and potassium (K) and to examine changes in tissue and ruminal fluid concentrations of these minerals in lambs. Eight lambs (39 kg) were used in trial 1 and 10 lambs (37 kg) were used in trial 2. Animals were used in randomized block designs, blocked by weight, and fed a high concentrate diet with or without 20 mg/kg monensin. Trials began with a dietary adjustment period lasting 18 d in trial 1 and 21 d in trial 2. Animals were then placed in metabolism stalls for a 10-d stall adjustment period followed by a 12-d collection period. Collections for mineral balance were made during the first 10 d of the collection period. Blood and ruminal fluid samples were obtained on d 11 of the collection period. Lambs were slaughtered on d 12 of the collection period and tissue samples were collected. Sodium retention decreased (P less than .05) 86.2% when monensin was fed. Apparent K absorption increased (P less than .05) 16.7%, while K retention increased (P less than .10) 52.6% when monensin was fed. In lambs fed monensin, ileal Na decreased (P less than .10) 13.8%. These results indicate that dietary monensin alters the metabolism of Na and K in lambs.
mesh_terms: D000818:Animals; D002414:Cations, Monovalent / Q000378:metabolism; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005503:Food Additives; D005663:Furans / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008985:Monensin / Q000494:pharmacology*; D009928:Organ Specificity; D011188:Potassium / Q000378:metabolism*; D012417:Rumen / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D002414:Cations, Monovalent; D005232:Fatty Acids, Volatile; D005503:Food Additives; D005663:Furans; D008985:Monensin; D012964:Sodium; D011188:Potassium