[A model of cooperative rearrangements of biological membranes without changes in the affinity of receptor binding centers].
A mathematical model is proposed for cooperative rearrangements induced by specific ligand in certain biomembrane domains. They are considered as the N-valent receptors undergoing rearrangement when n less than or equal to N ligand-binding receptor sites are occupied. The model predicts distinct sigmoidal dependence for change of some structural parameter on ligand concentration when the receptor site-ligand affinity remains constant as binding rises (positive cooperativity is absent).
D001665:Binding Sites; D007700:Kinetics; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological
D008024:Ligands; D008565:Membrane Proteins
Model' kooperativnykh perestroek biologicheskikh membran bez izmeneniia srodstva retseptornykh tsentrov sviazyvaniia.