Progesterone secreting Sertoli cell tumor of the ovary.
A 33-year-old woman presenting with secondary amenorrhea and galactorrhea was found to have a Sertoli cell tumor of the ovary. The neoplasm also had a sex cord tumor with annular tubules (SCTAT) component. Further investigations revealed that in many respects the patient was endocrinologically pregnant. She had markedly elevated serum estrogen and progesterone levels and the endometrium demonstrated pronounced decidualization, but there was no evidence of actual pregnancy. Estrogen and progesterone were demonstrated by immunohistochemistry to be present in both the Sertoli cell and SCTAT portions of the tumor.
D000328:Adult; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D011374:Progesterone / Q000378:metabolism*; D012707:Sertoli Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure
D011374:Progesterone