[Effect of synthetic polyribonucleotides on the immunological and colony-forming activity of irradiated bone marrow cells].
The experimental data are presented concerning the effect of polyribonucleotides on the immunologic and colony forming ability of bone marrow or irradiated mice. All the compounds under study exhibited a pronounced, but to a different degree, colony-forming and immunostimulating action. The comparative study of the influence of polyribonucleotides on the number of endogenous colonies and antibody-forming cells showed an inverse relationship between these parameters: The preparations exerting the most pronounced immunostimulating effect had an insignificant colony-forming action and vice versa. This is evidently indicative of the capacity of these preparations to turn the differentiation of haemopoietic stem cells towards the immunopoiesis.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D011131:Polyribonucleotides / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
D011131:Polyribonucleotides
Vliiani sinteticheskikh poliribonukleotidov na immunologicheskuiu i kolonieobrazuiushchuiu aktivnost' kletok obluchennogo kostnogo mozga.