[Pharmacokinetics of a new slow-release theophylline preparation in asthmatic children].
This study compares the pharmacokinetics of two preparations of slow-release theophylline, one of them already known, and the other one a new product (micronized), very well accepted by pediatric patients. Two similar groups of fifteen patients each all of then asthmatic children under ten years of age, were selected and given a single oral dose of 10 mg/kg of one of the preparations. The pharmacokinetic parameters (T 1/2, Kel, VD, Cl and AUC) did not differ between both groups. The new product could further be used more safely, due to its lower incidence of "erratic" behaviour.
D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D002214:Capsules; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D010316:Particle Size; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D002214:Capsules; D003692:Delayed-Action Preparations; D013806:Theophylline
Farmacocinética de una nueva preparación de teofilina retardada en niños asmáticos.