Similarity of effects--experimental hyperthermia as a teratogen and maternal febrile illness associated with oromandibular and limb defects.
Experimental hyperthermia in pregnancy causes oromandibular and limb anomalies. In humans, hyperthermia has been suspected of being teratogenic. Two patients were investigated; both had limb defects and one had oromandibular anomalies. Their mothers had a febrile illness at about the 10th wk of gestation. The similarity of defects produced by experimental hyperthermia and those reported here is striking.
D000015:Abnormalities, Multiple / Q000209:etiology*; D000328:Adult; D000818:Animals; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000150:complications*; D006801:Humans; D006979:Hyperthermia, Induced; D007223:Infant; D017880:Limb Deformities, Congenital; D008297:Male; D008334:Mandible / Q000002:abnormalities*; D009056:Mouth Abnormalities / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications