Effect of gestational and neonatal styrene exposure on dopamine receptors.
The effect of styrene (200 mg/kg, orally) on dopamine receptor binding using 3H-spiroperidol as a specific ligand was studied in developing rats. Gestational exposure caused no significant change in the binding of 3H-spiroperidol to striatal membranes of pups at 2 and 3 weeks of age. However, styrene exposure during lactation and the gestation-lactation period caused a significant increase in binding of 3H-spiroperidol. Scatchard analysis revealed that styrene exposure caused an increase in the number of receptor sites without affecting their affinity. Results of behavioral studies (amphetamine-induced locomotor activity and apomorphine-induced stereotypy) showed that styrene exposure during the gestation-lactation period caused a significant increase in motor activity and stereotypy of the rat pups. These behavioral and biochemical studies suggest that early postnatal exposure to styrene affects dopaminergic function.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001058:Apomorphine / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007774:Lactation; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*; D020058:Styrene; D013343:Styrenes / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013343:Styrenes; D020058:Styrene; D000661:Amphetamine; D001058:Apomorphine