Inhibition of fatty acid synthesis in rabbit mammary alveolar explants by progesterone and related steroids.
The possible inhibitory effect of steroids related to progesterone on prolactin-stimulated fatty acid synthesis in mammary alveolar explants from 11-day pseudopregnant rabbits, after culture, was investigated. Like progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-dihydroprogesterone, medroxyprogesterone acetate, ethinodiol diacetate, ORG 2058 were inhibitory whereas pregnenolone and 5 alpha-pregnan-3,20-dione were not.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis*; D005260:Female; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000378:metabolism*; D009924:Organ Culture Techniques; D011374:Progesterone / Q000494:pharmacology*; D011372:Progestins / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011555:Pseudopregnancy; D011817:Rabbits; D013329:Structure-Activity Relationship
D000085:Acetates; D005227:Fatty Acids; D011372:Progestins; D011374:Progesterone; D019342:Acetic Acid