Concentration-dependent respiratory response of guinea pigs to a single exposure of cotton dust.
Eight groups of guinea pigs were exposed to cotton dust at concentrations of 2 to 27 mg/m3. Each exposure was for 6 hr. The pulmonary function of each animal was assessed prior to exposure, following exposure, and 18 hr following exposure. Tidal volume decreased while respiratory frequency increased in a concentration-dependent manner. These changes were amplified when the same measurements were conducted while the animals were breathing an atmosphere containing 10% CO2 in 19% O2 and 71% N2. Greatest response was noted at 18 hr postexposure. The concentration-response effects can be applied to evaluate the respiratory potencies of different cotton dusts grown under a variety of conditions.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D002095:Byssinosis / Q000209:etiology*; D004391:Dust; D003368:Gossypium / Q000633:toxicity*; D006168:Guinea Pigs; D008297:Male; D010316:Particle Size; D010993:Plethysmography, Whole Body; D012119:Respiration; D013990:Tidal Volume
D004391:Dust