title: The role of the cell cycle in differentiation of the cellular slime mould Dictyostelium discoideum.
abstract: During development and differentiation of the cellular slime mould Dictyostelium discoideum there appears to be a relationship between the cell cycle and cell fate: amoebae halted in G2 phase during early development differentiate into spores whereas stalk cells are formed from amoebae halted in G1 phase. It is proposed that this is because a major effect of the cell cycle is to generate heterogeneity in the cell surface properties of the developing amoebae.
mesh_terms: D002453:Cell Cycle; D002454:Cell Differentiation; D002462:Cell Membrane / Q000502:physiology; D003377:Countercurrent Distribution; D004023:Dictyostelium / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D005656:Fungal Proteins / Q000502:physiology; D006023:Glycoproteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D013172:Spores, Fungal
chemical_list: D005656:Fungal Proteins; D006023:Glycoproteins; D008565:Membrane Proteins