[Age-related changes in adenylate cyclase activity, lipid composition and lipid peroxidation in rat intestinal mucosa: comparison with the frequency of spontaneous tumors].
The study used 3, 7, 16 and 22 month-old male rats bred at the animal farm of the Institute. Identical age-related changes were established in the level of free cholesterol, its esters, free cholesterol/phospholipids and sphingomyelin/lecithin ratios in ascending and descending colon mucosa. Unlike descending colon mucosa, the basal and hormone-stimulating activity of adenylate cyclase and rate of lipid peroxidation in the mucosa of the ascending colon of 22 month-old animals were lower than in 16 month-old rats. The results are compared with the available data on the predominant localization of spontaneous tumors in the proximal (ascending) part of rat's intestine.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000375:Aging; D000818:Animals; D007413:Intestinal Mucosa / Q000378:metabolism*; D007414:Intestinal Neoplasms / Q000378:metabolism / Q000662:veterinary*; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051381:Rats
D008054:Lipid Peroxides; D000262:Adenylyl Cyclases
Vozrastnye izmeneniia aktivnosti adenilattsiklazy, lipidnogo sostava i perekisnogo okisleniia lipidov v slizistoĭ obolochke kishechnika u krys: sopostavlenie s chastotoĭ spontannykh opukholeĭ.