Normolipemic activities of acrylophenone derivatives with antimicrotubular properties.
Acrylophenone derivatives with in vitro antimicrotubular activities very similar to those of colchicine were tested on Triton WR 1339-induced hyperlipidemia in rats. They exhibit high normolipemic activity on plasmatic apolipoproteins AI and B, contrasting with inactivity on plasmatic lipids and lipoproteins.
D000179:Acrylates / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001053:Apolipoproteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D006949:Hyperlipidemias / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents; D007659:Ketones / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008870:Microtubules / Q000187:drug effects*; D010743:Phospholipids / Q000097:blood; D011092:Polyethylene Glycols; D051381:Rats; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
D000179:Acrylates; D001053:Apolipoproteins; D000960:Hypolipidemic Agents; D007659:Ketones; D010743:Phospholipids; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol