[Experimental and clinical studies on calcium urolithiasis: (I) Animal model for calcium oxalate urolithiasis using ethylene glycol and 1-alpha (OH) D3].
As calcium oxalate stones are the most important component in urolithiasis, an experimental model has to be designed to clarify the pathogenesis and aid in their prevention. Hyperoxaluria as well as hypercalciuria were produced in rats by administering ethylene glycol (0.5%, in drinking water administered ad libitum) and 1-alpha (OH) D3 (0.5 micrograms/rat given every other day), respectively, for three to four weeks. Neither drug alone produced stones efficiently as did the combination regimen of these two compounds. The occurrence of stones was 77.3%, and with only a moderate degree of renal functional impairment. Biochemical and histological data were obtained using this model.
D000818:Animals; D002118:Calcium / Q000652:urine; D002129:Calcium Oxalate / Q000378:metabolism* / Q000652:urine; D005026:Ethylene Glycols / Q000633:toxicity*; D006887:Hydroxycholecalciferols / Q000633:toxicity*; D007668:Kidney / Q000503:physiopathology; D007669:Kidney Calculi / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D008274:Magnesium / Q000652:urine; D008297:Male; D010070:Oxalates / Q000652:urine; D010710:Phosphates / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D014514:Ureteral Calculi / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D014545:Urinary Calculi / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D005026:Ethylene Glycols; D006887:Hydroxycholecalciferols; D010070:Oxalates; D010710:Phosphates; D002129:Calcium Oxalate; D008274:Magnesium; D002118:Calcium; C008088:alfacalcidol