Pharmacokinetics of flunixin meglumine in the cow.
Plasma levels of flunixin were measured in heifers after a single intravenous injection (1.1 mg kg-1), using high performance liquid chromatography. Plasma concentration versus time curves were best described by a two compartment model. The distribution phase (alpha) half-life was 0.294 hours, the elimination phase (beta) half-life was 8.12 hours and the volume of distribution was 1050 ml kg-1.
D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003002:Clonixin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*; D003201:Computers; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D009539:Nicotinic Acids / Q000378:metabolism*
D009539:Nicotinic Acids; C014558:flunixin meglumine; D003002:Clonixin