[Modifying action of neonatal androgenization on 1,2-dimethylhydrazine-induced carcinogenesis in male CBA-strain mice].
Newborn male CBA mice received a single treatment with 0.5 mg testosterone propionate. Weekly subcutaneous injections of 1,2-dimethylhydrazine (DMH) were given to 2-month-old mice. The incidence of pararenal angiosarcomas and colonic tumors in neonatally androgenized mice reached 78.5 and 71.0%, respectively by the 35th week after the DMH treatment was commenced. In DMH-treated control mice, the incidence of the above tumors amounted to 25 and 32%, respectively.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D000831:Animals, Newborn; D004127:Dimethylhydrazines; D006394:Hemangiosarcoma / Q000139:chemically induced*; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects; D013997:Time Factors
D004127:Dimethylhydrazines; D013739:Testosterone; D019813:1,2-Dimethylhydrazine
Modifitsiruiushchee deĭstvie neonatal'noĭ androgenizatsii na indutsirovannyĭ 1,2-dimetilgidrazinom kantserogenez u mysheĭ-samtsov linii CBA.