Enhanced myotoxicity and involvement of both type I and II fibers in monensin-tiamulin toxicosis in pigs.
Simultaneous administration of monensin and tiamulin to pigs resulted in enhanced myotoxicity. Skeletal muscles of tongue, diaphragm and legs were preferentially affected, whereas the masseter, longissimus thoracis and cardiac muscles, including the left auricle, were spared. Histochemical examination revealed an involvement of both type I and II fibers of skeletal muscles.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D004224:Diterpenes / Q000633:toxicity; D004357:Drug Synergism; D005503:Food Additives; D005663:Furans / Q000633:toxicity*; D006651:Histocytochemistry; D008297:Male; D008985:Monensin / Q000633:toxicity*; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000473:pathology; D014886:Weaning
D000900:Anti-Bacterial Agents; D004224:Diterpenes; D005503:Food Additives; D005663:Furans; D008985:Monensin; C014224:tiamulin