Phenotype and gene frequencies of acid phosphatase (s-AcP) in the human parotid saliva.
Genetic polymorphism of the human parotid salivary acid phosphatase (s-AcP) in the Japanese population is described. The use of polyacrylamide gel isoelectric focusing electrophoresis with the pH range of 4.0-6.5 enabled us to discern three variant patterns controlled by two codominant alleles at the single autosomal locus. The two alleles were designated s-AcP:A and s-AcP:a, and the gene frequencies calculated from 183 Japanese subjects were s-AcP:A = 0.2268 +/- 0.022, s-AcP:a = 0.7732 +/- 0.022, respectively. The distribution of phenotypes fitted the Hardy-Weinberg equilibrium.
D000135:Acid Phosphatase / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D007564:Japan; D010306:Parotid Gland / Q000378:metabolism; D010641:Phenotype; D011110:Polymorphism, Genetic; D012463:Saliva / Q000201:enzymology*
D000135:Acid Phosphatase