Effects of exchange transfusion with perfluorochemical emulsions on hepatic oxygen supply and blood flow in the rat.
Exchange-transfusion to hematocrit 20 with isotonic perfluorochemical (PFC) emulsions containing 3% hydroxyethylstarch (HES) in rats breathing 100% oxygen produced significant reductions of hepatic PO2 and blood flow in comparison to rats hemodiluted with isotonic 3% or 6% HES solution. The results indicate that PFC and/or emulsifiers were associated with adverse effects on liver blood supply.
D000818:Animals; D001802:Blood Substitutes; D001803:Blood Transfusion; D004338:Drug Combinations; D005466:Fluorocarbons; D006207:Half-Life; D006400:Hematocrit; D006895:Hydroxyethyl Starch Derivatives; D007208:Indocyanine Green / Q000378:metabolism; D008099:Liver / Q000098:blood supply*; D010101:Oxygen Consumption; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C008807:perfluorotributylamine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D007208:Indocyanine Green