title: Inhibition of platelet function by uremic middle molecules.
abstract: To further define the platelet abnormality responsible for uremic bleeding, we studied platelet aggregation with adenosine diphosphate, ristocetin, and collagen in serum fractions obtained by Sephadex G-15 chromatography. We found that uremic patients had considerable inhibition in several peaks of middle molecular range, but the findings were inconsistent and not clearly related to the degree of uremia.
mesh_terms: D001792:Blood Platelets / Q000502:physiology*; D002850:Chromatography, Gel; D006801:Humans; D010974:Platelet Aggregation; D014118:Toxins, Biological / Q000097:blood*; D014511:Uremia / Q000097:blood*
chemical_list: D014118:Toxins, Biological; C026865:uremia middle molecule toxins