A ferritin-containing cell type in the stria vascularis of the mouse inner ear.
This report describes a new cell type within the stria vascularis of the mouse inner ear. The cell is similar ultrastructurally to the classically described intermediate cell. However, it can be distinguished by the presence of dense vacuoles, presumably lysosomes, within which can be visualized electron dense particles resembling ferritin molecules. In addition, the ferritin-like particles are present throughout the cytoplasm and occasionally within the endoplasmic reticulum. These cells characteristically abut capillary basal lamina. Electron probe analysis of the dense vacuoles revealed the presence of iron. It is suggested that these cells may sequester iron released from dying erythrocytes in the strial capillary system, whereupon the iron is conserved through ferritin synthesis.
D000818:Animals; D003051:Cochlea / Q000166:cytology*; D003594:Cytoplasmic Granules / Q000032:analysis / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D005293:Ferritins / Q000032:analysis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D013316:Stria Vascularis / Q000166:cytology*; D014617:Vacuoles / Q000648:ultrastructure
D005293:Ferritins