Assessing modifications of the intestinal bacterial flora in patients on long-term oral treatment with bacampicillin or amoxicillin: a random study.
The authors conducted a randomized trial on 16 patients to evaluate intestinal aerobic microfloral changes after prolonged oral treatment with bacampicillin (b.) (16 g/die) or amoxicillin (a.) (2 g/die). The analysis showed a quantitative reduction of isolates in 6 patients: 2 patients were treated with b. while 4 with a. (Odd ratio, O.R. = 3). Mean values of CFU presented as well a more evident reduction in a.-treated patients. From the qualitative point of view, bacteria modifications occurred in one patient treated with b. and 3 with a, (O.R. = 4.2). Bacterial changes, although not statistically significant, were thus greater in patients treated with a. than b.
D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000494:pharmacology*; D000667:Ampicillin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008875:Middle Aged; D013997:Time Factors
D000667:Ampicillin; D000658:Amoxicillin; C011674:bacampicillin