title: [Multiple gangrene of the digits in a female patient with liver cirrhosis, diabetes mellitus and cryoglobulinemia].
abstract: A case is described with multiple gangrene of the fingers of a female, aged 55, with confirmed cirrhosis of liver and diabetes mellitus. Cryoglobulins were established in the serum. A disturbed immunological balance was present and the family loading with collagenosis raises the problem of genetic moments of the disturbed homeostasis. The existing diabetic microangiopathy, histologically confirmed by biopsy of skin and subcutaneous tissue, brings forward the question of the complex pathogenesis of gangrene. At the end of her stay in the clinic, the patient developed cerebral apoplexy.
mesh_terms: D002545:Brain Ischemia / Q000209:etiology; D003449:Cryoglobulinemia / Q000150:complications* / Q000473:pathology; D003925:Diabetic Angiopathies / Q000150:complications* / Q000473:pathology; D005260:Female; D005385:Fingers; D005734:Gangrene / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D014034:Toes
vernacular_title: Mnozhestveni gangreni na prŭstite pri bolna s chernodrobna tsiroza, zakharen diabet i krioglobulinemiia.