Cardiovascular effects of an ionophorous antibiotic, lonomycin A, in anesthetized dogs.
An intracoronary administration of ionomycin A, a K-selective ionophore, produced coronary vasodilation in the presence of pindolol in anesthetized dogs. Coronary vasodilation induced by ionomycin A, KCI and nifedipine was inhibited by pretreatment with an intracoronary injection of ouabain. This result suggests that lonomycin A-induced coronary vasodilation may be partly due to a stimulation of Na+, K+-ATPase as well as KCI and/or a decrease in Ca2+ influx as well as nifedipine.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D005260:Female; D007476:Ionophores / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D009550:Nigericin / Q000031:analogs & derivatives / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010869:Pindolol / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D007476:Ionophores; C012410:lonomycin; D010042:Ouabain; D011189:Potassium Chloride; D010869:Pindolol; D010208:Papaverine; D009543:Nifedipine; D007545:Isoproterenol; D009550:Nigericin