Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies.
The dissolution and absorption of poorly water-soluble drugs from rectal suppositories can be enhanced by complexing these substances (e.g., essential oils, indomethacin) with beta-cyclodextrin. Preliminary in vivo studies showed, that the application of cyclodextrin complexes to suppositories, the same as to oral applications, resulted in an increased blood level.
D000042:Absorption; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins; D003912:Dextrins; D007213:Indomethacin / Q000032:analysis; D012995:Solubility; D013213:Starch; D013488:Suppositories; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D003912:Dextrins; D013488:Suppositories; D047392:beta-Cyclodextrins; D013213:Starch; C031215:betadex; D007213:Indomethacin