Testicular morphology and cell proliferation kinetics of immature germ cells and Sertoli cells in suckling undernourished rats.
Undernutrition during suckling was induced in newborn rats by increasing the litter size to sixteen pups to be fed by one mother. Animals reared in litters of eight served as controls. Undernourished animals showed retarded body and testicular growth during a suckling period of 22 days. Sequential morphogenesis of the testis was not altered up to 15 days of age. However, certain morphological alterations in Sertoli cells and Leydig cells were observed from 15 days onwards. Cell generation cycle of spermatogonial germ cells and supporting cells (future Sertoli cells) on day 9 showed marked prolongation of DNA synthetic phase (S), unaltered post-DNA synthetic phase (G2) and total cycle (Tc) and shortening of the pre-DNA synthetic phase (G1) indicating a depression in DNA synthesis in undernutrition.
D000375:Aging; D000818:Animals; D000833:Animals, Suckling / Q000033:anatomy & histology; D001835:Body Weight; D002455:Cell Division; D005854:Germ Cells / Q000254:growth & development / Q000473:pathology*; D007700:Kinetics; D008297:Male; D009748:Nutrition Disorders / Q000473:pathology*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012708:Sertoli Cells / Q000473:pathology*; D013737:Testis / Q000473:pathology*