[Histoautoradiographic study of synthesis of neuronal proteins of the brain in response to exposure to damaging factors during the prenatal period].
The incorporation of 3H-leucine into the neuronal proteins of the hemispherical cortex and hyppocampus was studied in rats aged 1 and 3 months which were exposed to hypoxia and ethanol in the antenatal period. The test one-month-old animals showed activation of protein synthesis in neurons and in layers III and V of the cortex and hyppocampus. At the age of 3 months the rats showed inhibited incorporation of the label into neuronal proteins of the studied structures of the brain which was more expressed in animals which had suffered intrauterine hypoxia.
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000378:metabolism*; D005311:Fetal Hypoxia / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011247:Pregnancy; D051381:Rats
D009419:Nerve Tissue Proteins; D007930:Leucine
Gistoavtoradiograficheskoe issledovanie sinteza neĭronal'nykh belkov golovnogo mozga pri deĭstvii povrezhdaiushchikh faktorov v antenatal'nom periode.