Rhinocerebral mucormycosis with internal carotid occlusion: report of two cases and review of the literature.
Two fatal cases of rhinocerebral mucormycosis with fungal invasion and occlusion of the internal carotid artery are described. Review of the literature reveals 35 similar cases of whom only 6 survived. Emphasis is placed on the need for early diagnosis and prompt therapy which consists of correction of the underlying disease, aggressive surgical debridement, and amphotericin B.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009668:Nose Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery
D000666:Amphotericin B