The effect of nicotine on ethanol-induced gastric ulcers in rats.
Nicotine, in concentrations of 5 and 25 micrograms/ml drinking water, given ad libitum for 10 days, dose-dependently increased lesion formation and worsened ethanol-induced ulceration in rat stomachs. Daily fluid intake and b.wt gain were not adversely affected by nicotine pretreatment.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol; D005753:Gastric Mucosa / Q000473:pathology; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
D000431:Ethanol; D009538:Nicotine