Bioavailability of the thiamin administered as an adduct with menadione.
In order to investigate the bioavailability of thiamin present in the adduct with menadione bisulfite, urinary and faecalis excretion, blood levels and tissue content of thiamin in rats after oral administration of this compound, were measured. Since the quantity of thiamin excreted, the blood levels as well as the vitamin storage in the liver and kidney of rats treated with the adduct are similar to those of rats treated with corresponding quantities of thiamin HCl and menadione sodium bisulfite this means that the thiamin contained in the adduct reacts in the same way as free vitamin in the animal organism.
D000818:Animals; D001682:Biological Availability; D005243:Feces / Q000378:metabolism; D005260:Female; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013831:Thiamine / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D014812:Vitamin K / Q000008:administration & dosage*
D014812:Vitamin K; D013831:Thiamine