[Electron microscopy changes in hypophyseal lactotrophs in rats after the administration of metoclopramide].
Metoclopramide (Cerucal - Germed) proved to cause an ultrastructural activation of lactotroph cells in rat males. It showed itself as an increase of granular endoplasmic reticulum forming long lamellar or spiral structures. Many lactotrophs had a conspicuous Golgi zone. Estrogens and Metoclopramide administered simultaneously manifested themselves in a picture of heightened activation. The findings concurred with immunohistochemical ones from the same group of animals which issued earlier.
D000818:Animals; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D004958:Estradiol; D011388:Prolactin; D008787:Metoclopramide
Elektronmikroskopické zmĕny v krysích hypofyzárních laktotropech po podávání metoclopramidu.