Serum somatomedin-C and bioassayable growth-promoting activity (thymidine activity) in appropriate and small-for-gestational-age human newborns.
The serum level of radioimmunoassayable somatomedin-C and the bioassayable growth-promoting activity evaluated by the stimulating effect of serum upon thymidine incorporation into activated lymphocytes have been measured in the blood of term human foetuses. Comparison between those with a low birth weight and those with normal birth weight has shown that small-for-gestational-age subjects have lower somatomedin-C (0.31 +/- 0.03 vs 0.52 +/- 0.03) and thymidine activity (1.03 +/- 0.11 vs 1.50 +/- 0.07) (P less than 0.001). A positive correlation between somatomedin and thymidine activity was found. There was no difference in serum transferrin levels between both groups. It is suggested that somatomedin, and probably other growth-promoting factors measured by the thymidine bioassay, play a role in regulation of the foetal growth.
D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007334:Insulin-Like Growth Factor I; D008213:Lymphocyte Activation; D008297:Male; D013002:Somatomedins / Q000097:blood*; D013936:Thymidine / Q000097:blood*; D014168:Transferrin / Q000097:blood
D013002:Somatomedins; D014168:Transferrin; D007334:Insulin-Like Growth Factor I; D013936:Thymidine