Synthesis and N.M.R. study of trans 2-phenoxycyclohexanol and some of its derivatives with potential antiinflammatory activity.
A number of amino-ethers, acids, amino-esters, amino-amides and carbamates was synthesized from trans-2-phenoxycyclohexanol. The configuration of the starting material was established by N.M.R. spectroscopy. Pharmacological tests showed an antiinflammatory activity for some of the derivatives.
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003511:Cyclohexanols / Q000138:chemical synthesis* / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051381:Rats
D000577:Amides; D000588:Amines; D000893:Anti-Inflammatory Agents; D002219:Carbamates; D003511:Cyclohexanols; D004952:Esters