Incorporation of 35sulfate into the glomerular basement membrane in puromycin aminonucleoside nephrosis.
The in vitro incorporation of 35sulfate into the glomerular basement membrane (GBM) of rats with puromycin aminonucleoside was compared with that of normal rats. 35Sulfate incorporation into the GBM of glomeruli from nephrotic rats did not differ significantly from that observed in normal rats. These data suggest that 35sulfate anionic charges in the GBM play no important role in the pathogenesis of the proteinuria in this experimental model.
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D009401:Nephrosis / Q000139:chemically induced* / Q000378:metabolism; D011507:Proteinuria / Q000139:chemically induced / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism; D011691:Puromycin / Q000031:analogs & derivatives*; D011692:Puromycin Aminonucleoside / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes
D011509:Proteoglycans; D013462:Sulfur Radioisotopes; D011691:Puromycin; D011692:Puromycin Aminonucleoside