title: Fatal acute respiratory failure after vinblastine-mitomycin therapy in lung carcinoma.
abstract: The occurrence of pulmonary toxic reaction due to vinblastine sulfate alone or in combination with drugs other than mitomycin is not known. Acute respiratory distress is a rare phenomenon in patients receiving both chemotherapeutic agents. Two cases of fatal acute respiratory failure due to pulmonary edema occurred in patients receiving vinblastine-mitomycin for non-small-cell carcinoma of the lung. In view of the unpredictability of the reaction, observation of patients receiving this combination therapy is recommended.
mesh_terms: D000208:Acute Disease; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage / Q000009:adverse effects; D011654:Pulmonary Edema / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D008937:Mitomycins; D014747:Vinblastine