title: Development of speech and language following bilateral frontal lesions.
abstract: Language and speech were studied in a young child with perinatally acquired bifrontal lesions. Bilateral frontal pathology seriously interfered with the development of intelligible speech and resulted in a persistent expressive aphasia. Analysis of the neuropsychological profile indicated impairments in intelligence and language comprehension. These deficits, however, were considered secondary to the profound speech programming disorder. The findings indicate that, despite the plasticity of the immature central nervous system, bilateral frontal injury sustained at an early age precludes the development of intelligible speech. Furthermore, structurally intact cortical regions outside the territories of the speech zones fail to mediate normal speech and language development.
mesh_terms: D001037:Aphasia / Q000151:congenital*; D001039:Aphasia, Broca / Q000151:congenital* / Q000523:psychology; D001720:Birth Injuries / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003071:Cognition; D005625:Frontal Lobe / Q000293:injuries*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007804:Language Development; D008297:Male; D008568:Memory; D013060:Speech; D013067:Speech Perception