[Differences and similarity in the interaction of fenibut, baclofen and diazepam with phenylethylamine].
The derivatives of GABA and beta-phenylethylamine (PEA) the tranquilizer phenibut and muscle relaxant baclofen (p-chloro-beta-phenyl-GABA, lioresal) diminished all studied effect of PEA in mice, namely seizures, sedation, excitation, hyperthermia. Diazepam diminished only seizures whereas haloperidol excitation and hyperthermia. PEA injections anatogonized (the sedative and hypothermic effects of phenibut and diazepam and the anticonvulsant (against l-kynurenine) effect of phenibut and baclofen. The role of antagonism to PEA in the mechanism of the antianxiety effect of tranquilizers is discussed.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009949:Orientation / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013997:Time Factors; D014149:Tranquilizing Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D010627:Phenethylamines; D014149:Tranquilizing Agents; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D003975:Diazepam; C008842:4-amino-3-phenylbutyric acid
Razlichiia i skhodstvo vo vzaimodeĭstviia fenibuta, baklofena i diazepam s fenilétilaminom.