Comparison of glycogen stores in 3- and 7-month-old lean and obese Zucker rats under fed and fasted conditions.
Glycogen content (mg/g) and stores (mg) were determined in 3- and 7-month-old obese and lean Zucker rats, under fed and fasted (48 hr) conditions. Hepatic content was higher in fed obese than in lean rats (3 months: 90 vs 70; 7 months: 107 vs 74); it was exhausted after fasting in lean but decreased by 56% in obese rats. Muscle content in fed obese and lean animals did not differ; it decreased comparably after fasting. Myocardial content was higher in fed obese than lean rats (3 months: 7.2 vs 3.6; 7 months: 7.5 vs 6.3); it was enhanced with fasting (10.0 vs 7.5). Total glycogen stores were higher in obese than in lean animals (3 months: 2500 vs 1400; 7 months: 4000 vs 2000) because of the hepatic store. The discussion includes a comparison with available data, taking into account methodological aspects, lipid stores and the FFA/carbohydrate interrelationship.
D000375:Aging; D000818:Animals; D004435:Eating; D005215:Fasting; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000254:growth & development*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker; D013045:Species Specificity
D008112:Liver Glycogen; D006003:Glycogen