title: Complications with antibiotics used prophylactically in joint replacement surgery: a case report of cephradine-induced pseudomembranous colitis.
abstract: A woman underwent joint replacement surgery with prophylactic antibiotic cover, and subsequently died as a result of pseudomembranous colitis. We have noted a high incidence of antibiotic diarrhoea with cephradine, and suggest that if administration of prophylactic antibiotics is restricted to 3 days or less, the incidence of diarrhoea would diminish, and the therapeutic value of the antibiotics would be maintained.
mesh_terms: D000368:Aged; D002511:Cephalosporins / Q000009:adverse effects*; D002515:Cephradine / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007595:Joint Prosthesis; D007720:Knee Prosthesis; D008297:Male; D011183:Postoperative Complications; D011292:Premedication / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D002511:Cephalosporins; D002515:Cephradine