[Photodynamic therapy of superficial tumors and carcinoma in situ of the bladder].
Photodynamic therapy (PDT), in which hematoporphyrin derivative is activated by an argon-dye laser, was performed on 36 superficial tumors using a 400 micron quartz fiber and cystoscope (spot PDT), and also carried out in 7 patients with primary or secondary CIS, 9 patients with secondary CIS associated with TaTl tumors and 2 patients with multiple small tumors, using a motor-driven laser light scattering optic automatically controlled by a computer (total PDT). In spot PDT, for tumors up to 2 cm in size the light intensity should be 300 mW/cm2 for 5 to 10 minutes or more. For the CIS therapy, the light dose used was 10 to 30 Joules/cm2. There has been no recurrence at present in 8 of the 18 patients at a mean follow-up period of 6.6 months. The techniques and problems associated with total PDT are reported.
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
D006415:Hematoporphyrins