[Evaluation of the pain-alleviating properties of a combination of analgesic and tranquilizer using multiple stepwise regression].
A method for preclinical evaluation of the optimal ratio (for analgesia) of an analgesic to a tranquilizer has been devised. It is based on the drug threshold dose decrease on the drug combined use. The multiple stepwise regression analysis of the data discovered the correlations between diazepam and promedol, optimal for pain perception decrease and nociceptive emotional responsiveness inhibition.
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D003975:Diazepam; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D010146:Pain / Q000188:drug therapy*; D011396:Promedol; D051381:Rats; D012044:Regression Analysis; D012684:Sensory Thresholds / Q000187:drug effects; D014149:Tranquilizing Agents / Q000008:administration & dosage*
D000700:Analgesics; D014149:Tranquilizing Agents; D011396:Promedol; D003975:Diazepam
Otsenka boleutoliaiushchikh svoĭstv kombinatsii anal'getika i trankvilizatora s pomoshch'iu mnozhestvennoĭ poshagovoĭ regressii.