[New psychotropic agents. I. Synthesis and pharmacologic activity of derivatives of 5H-imidazo-[2,1-c][1,4]benzodiazepine].
The synthesis of 5H-imidazo [2,1-c] [1,4] benzodiazepine derivatives is described. Hydroxymethylation of 1-(2-nitrobenzyl)imidazoles by reaction with formaldehyde in a sealed tube and subsequent oxidation of hydroxymethylimidazoles with activated manganese dioxide afforded 1-(2-nitrobenzyl)imidazole-2-carboxaldehydes. The latter compounds were treated with iron(II) sulphate to yield directly the expected tricyclic imidazobenzodiazepines by intramolecular cyclization of the intermediates aminoaldehydes. The tricyclic derivatives were subjected to pharmacological screening to evaluate the effects on the behavior of the animals and the interaction with some biogenic amines. Some of the tested compounds were comparable to chlordiazepoxide in sedative and muscle-relaxant activities. None of them showed antiserotonin, anticholinergic or adrenolytic activities.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D051381:Rats
D001679:Biogenic Amines; D011619:Psychotropic Drugs; D001569:Benzodiazepines
Ricerche su nuovi agenti psicotropi. I. Sintesi ed attività farmacologica di derivati della 5H-imidazo-[2,1-c] [1,4] benzodiazepina.