title: Nitrous oxide solubility in halothane and its effect on the output of vaporizers.
abstract: The absorption of nitrous oxide in halothane was studied by bubbling nitrous oxide and nitrous oxide/oxygen gas mixtures through a halothane bottle, using 100% oxygen as a control. The gas volume emerging from the halothane bottle was measured each minute, over a period of up to 15 minutes. When oxygen was used as a control gas, the averaged flow rate dropped slightly over the experimental period, due to the cooling of the halothane. However, in the presence of nitrous oxide, the initial flow rate of the gas emerging from the halothane bottle was greatly diminished, but then accelerated rapidly to reach that obtained with oxygen. The results suggested that nitrous oxide dissolved in large quantities in halothane, and the data are consistent with an Ostwald coefficient in excess of 4.0.
mesh_terms: D000042:Absorption; D000769:Anesthesia, Inhalation / Q000295:instrumentation; D006221:Halothane; D006801:Humans; D009609:Nitrous Oxide; D012995:Solubility; D013696:Temperature; D013997:Time Factors; D014835:Volatilization
chemical_list: D009609:Nitrous Oxide; D006221:Halothane