[Suppression of the formation of cells secreting antibodies and antigen-dependent nonspecific immunoglobulins in mice receiving isologous antierythrocyte immunoglobulins].
Mice injected with syngeneic cellulose-conjugated immunoglobulins (Ig) containing antibodies to sheep red blood cells (SRBC) develop a specific non-responsiveness to SRBC. Such animals demonstrate a sharp decrease not only in the formation of anti-SRBC antibody producers but also of the cells secreting antigen-dependent nonspecific Ig. The inhibition of both these processes is antigen-specific. It is suggested that inhibition of the cells forming antigen-dependent nonspecific Ig is due to suppression of either hypothetic inductors or precursors of these cells expressing an idiotype spectrum similar to that of anti-SRBC antibody producers.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D007136:Immunoglobulins / Q000276:immunology*; D051379:Mice
D000941:Antigens; D007136:Immunoglobulins
Ugnetenie obrazovaniia kletok, sekretiruiushchikh antitela i antigenzavisimye nespetsificheskie immunoglobuliny, u mysheĭ, poluchavshikh izologichnye antiéritrotsitarnye immunoglobuliny.