Determination of certain physical and chemical characteristics of the activating serum factor from preparturient women and women with habitual abortions.
Follow-up investigation of the blood sera from preparturient women and women with habitual abortions showed the presence of a factor which has an activating effect on smooth muscle preparations because it causes the release of prostaglandins. Gel-chromatographic counter flow separation and microelectrophoresis of the blood sera have shown that the isolated serum factor is a water soluble glycopeptide with a molecular weight of about 2000.
D000026:Abortion, Habitual / Q000097:blood*; D000818:Animals; D005260:Female; D006023:Glycoproteins / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007743:Labor, Obstetric; D008970:Molecular Weight; D009130:Muscle, Smooth / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D006023:Glycoproteins; D007213:Indomethacin