title: Peroxidase activity at nodes of Ranvier in some commonly used laboratory animals after intramuscular administration of horseradish peroxidase.
abstract: During retrograde transport of intramuscularly administrated horseradish peroxidase (HRP) nodal axon segments of rabbit, rat, and mouse peripheral nerve fibers became HRP-positive and showed a striking proximodistal segregation of certain axoplasmic organelles. HRP-positive bodies and HRP-negative vesiculotubular membrane profiles were seen just distal and proximal to the nodal midlevel, respectively. This appearance was similar to that found earlier in HRP-transporting feline muscle nerve fibers. Some mechanisms that might explain the segregated appearance are briefly discussed.
mesh_terms: D000818:Animals; D002415:Cats; D006735:Horseradish Peroxidase / Q000008:administration & dosage; D007273:Injections, Intramuscular; D010544:Peroxidases; D011817:Rabbits; D011901:Ranvier's Nodes / Q000648:ultrastructure*; D012377:Rodentia
chemical_list: D006735:Horseradish Peroxidase; D010544:Peroxidases