title: Uncertainty factors and interindividual variation.
abstract: Human variation in response to environmental agents appears often greater than a factor of 10, sometimes even up to several orders of magnitude. However, the vast majority of people studied to date respond within a factor of 10. The implications of these findings for the current use of uncertainty factors in regulatory toxicology is discussed.
mesh_terms: D000107:Acetylation; D002273:Carcinogens / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004198:Disease Susceptibility; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007206:Individuality; D004364:Pharmaceutical Preparations / Q000378:metabolism; D012306:Risk; D014116:Toxicology
chemical_list: D002273:Carcinogens; D004364:Pharmaceutical Preparations; D004247:DNA