Effect of vitamin E on cholesterol plasma lipoprotein distribution and metabolism in rabbit.
In the rabbit, after nine weeks on a basal synthetic diet supplemented with stripped corn oil and varying amount of vitamin E, plasma cholesterol level was depressed as the supplementation of vitamin E was increased. This hypocholesterolemic effect was accompanied by an increase in hepatic cholesterol-7 alpha-hydroxylase activity and cytochrome P-450 level and by a redistribution of plasma lipoprotein-cholesterol resulting in the elevation of high density to low density lipoprotein-cholesterol ratio.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D002914:Chylomicrons / Q000378:metabolism; D003314:Corn Oil; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D009821:Oils; D011817:Rabbits; D014810:Vitamin E / Q000378:metabolism*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002914:Chylomicrons; D003573:Cytochrome b Group; D008079:Lipoproteins, VLDL; D009821:Oils; D014810:Vitamin E; D003314:Corn Oil; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase