[Experimental study of the antimutagenic properties of 5-methylresorcinol].
A study was made of the effect of 5-methylresorcinol (5-MR) on mutagenic activity of benzo(a)pyrene (BP) and of the action of gamma-radiation in in-vitro and in-vivo systems. The induction of direct gene mutations in Chinese hamster cells V-79 and micronuclei in mouse bone marrow reticulocytes was efficiently suppressed by 5-MR treatment. The antimutagenic activity of 5-MR can be explained by inhibition of free-radical processes.
D000818:Animals; D001564:Benzo(a)pyrene / Q000494:pharmacology; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004347:Drug Interactions; D005720:Gamma Rays; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D009154:Mutation; D012118:Resorcinols / Q000494:pharmacology*; D012156:Reticulocytes / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors
D012118:Resorcinols; D001564:Benzo(a)pyrene; C005282:orcinol; D007041:Hypoxanthine Phosphoribosyltransferase
Eksperimental'noe izuchenie antimutagennykh svoĭstv 5-metilrezotsina.