Splenomegaly in mice following exposure to ambient levels of ozone.
Female strain A/J mice were exposed to 0.31 ppm (608 micrograms/m3) ozone continuously for 103 h every other week for 6 mth. Following an additional period of 5 mth in a filtered air environment, animals were killed and examined for evidence of altered spleen weight. It was observed that animals exposed to ozone had a greater spleen weight, and spleen to body weight ratio than air-breathing controls. In some of the ozone-exposed mice, pronounced splenomegaly was noted. Increased spleen weight appears to be another example of an extrapulmonary effect of ozone inhalation.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D005260:Female; D051379:Mice; D008805:Mice, Inbred A; D009929:Organ Size / Q000187:drug effects; D010126:Ozone / Q000633:toxicity*; D013154:Spleen / Q000473:pathology; D013163:Splenomegaly / Q000139:chemically induced*; D013950:Thymus Gland / Q000473:pathology
D010126:Ozone