[The role of erythrocyte deformability in the prolonged bleeding time in liver disease patients].
Hematocrit (Ht), red cell deformability (RCD) determined using a filtration method and bleeding time (BT) have been studied in 28 patients with severe chronic liver disease. Our results show a decrease of Ht (p less than 0.001), RCD (p less than 0.05) and a prolongation of BT (p less than 0.001) not related to the platelet count. Moreover, inverse relationships between Ht and BT (r = -0.52; p less than 0.01) and between RCD and BT (r = -0.54; p less than 0.01) have been found. We conclude that hemorheological alterations, such as decreased Ht and RCD, play an important role in primary hemostasis of patients with chronic liver disease.
D000328:Adult; D000368:Aged; D001760:Bleeding Time; D004907:Erythrocyte Deformability; D005260:Female; D005374:Filtration; D006400:Hematocrit; D006801:Humans; D008107:Liver Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010979:Platelet Function Tests; D012212:Rheology
Ruolo della deformabilità eritrocitaria sul prolungamento del tempo di emorragia nel paziente epatopatico.