[Changes in the energy resources of rat gastric mucosa exposed to dopamine agonists and antagonists in conditions of experimental stress].
Changes in adenyl nucleotide and glycogen content in rat gastric tissue under the action of stressogenic factor and injection of the dopamine blocker metoclopramide and the dopamine precursor L-DOPA were investigated with the use of the "social stress" method devised by the authors. It was established that stress induced gastric mucosal lesions and reduced the content of adenyl nucleotides and glycogen in the gastric tissue. Preliminary injection of L-DOPA potentiated the effect of stress while metoclopramide inhibited it. The data show a role of energy balance disturbances in the gastric tissue in the pathogenesis of an acute ulcer. In the authors' opinion, the disturbances seen during immobilization psychogenic stress were caused by undue stimulation of central dopamine receptors.
D000818:Animals; D004734:Energy Metabolism; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism*
D007980:Levodopa; D008787:Metoclopramide
Izmeneniia énergeticheskikh resursov slizistoĭ obolochki zheludka krys pod vliianiem dofaminovykh agonistov i antagonistov v usloviiakh éksperimental'nogo stressa.