Isoimmunization in pregnancy to Gerbich antigen.
A case of hemolytic disease of the newborn due to Gerbich, a public antigen, is presented. The antibody which was IgG1 reacted in vitro with mononuclear phagocytes. Serial sonographic and amniotic fluid examinations were followed and a mildly jaundiced neonate was delivered. Further investigation may establish a relationship between severity of disease and IgG subclasses, a mononuclear phagocyte assay, and sonographic measurements. Sources of compatible blood for possible maternal, fetal, or neonatal transfusion include blood bank rare donor files, relatives, and autologous donation.
D000328:Adult; D001789:Blood Group Antigens / Q000276:immunology; D004899:Erythroblastosis, Fetal / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology*; D007518:Isoantibodies / Q000145:classification / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology; D011247:Pregnancy
D001789:Blood Group Antigens; D007074:Immunoglobulin G; D007518:Isoantibodies; D007519:Isoantigens