[Increased hepatocyte resistance to CC14 following the stimulation of rats with a bacterial polysaccharide].
It has been established in male Wistar rats that the uptake capacity of the reticuloendothelial system (RES) increased 5-fold 1, 3 and 7 days after prodigiozan administration (50 micrograms). This was linked with the increased hepatocyte resistance to CCl4 which reached a maximum 7 and 21 days after RES stimulation. As compared with non-stimulated animals, the resistance increase looked as a 2.7- and 3.5-fold shrinkage of the necrotic zones in the central parts of liver lobules 24 h after CCl4 poisoning and less increment of alanine aminotransferase activity in blood serum (3.5- and 3.3-fold decrease, respectively). The increased resistance continued being recordable throughout a month after prodigiozan treatment.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors*; D004351:Drug Resistance; D007728:Kupffer Cells / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013997:Time Factors
D011135:Polysaccharides, Bacterial; D011354:Prodigiozan; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase
Povyshenie rezistentnosti gepatotsitov k CC14 posle stimuliatsii krys bakteriĭnym polisakharidom.