Activation of the impaired nasal mucociliary function. A preliminary clinical study.
The effect of HR-6 solution containing adenosine triphosphate 10 mg/ml on the impaired nasal mucocililary function in 13 patients was studied. The nasal mucociliary function measured with the radioisotopic method using 99Tc-labelled human serum albumin as a tracer substance was markedly impaired in all patients. The patients had had symptoms of upper and/or lower respiratory tract infections for 8 1/2 years, on the average. The nasal mucociliary function ranged from 0 to 5.0 mm/minute, mean 2.0 mm/minute. In this single dose study the test drug improved nasal mucociliary function by at least 1.4 mm/minute in 77% of the patients and by at least 2.8 mm/minute in 54% of the patients. This preliminary study indicates the need for further examinations with the HR-6 in patients with impaired mucociliary function.
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D002648:Child; D002923:Cilia / Q000503:physiopathology; D002925:Ciliary Motility Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D011877:Radionuclide Imaging; D012141:Respiratory Tract Infections / Q000503:physiopathology*; D013668:Technetium Tc 99m Aggregated Albumin
D013668:Technetium Tc 99m Aggregated Albumin; D000255:Adenosine Triphosphate