Acute interstitial nephritis associated with mezlocillin, nafcillin, and gentamicin treatment for Pseudomonas infection.
Two patients developed acute interstitial nephritis (AIN) following treatment with mezlocillin sodium. Diagnosis was made by renal biopsy. Gallium 67 citrate scanning was abnormal in both. All patients were receiving multiple-drug therapy, but AIN has either not been described with the other drugs, or the temporal relationship between the AIN and termination of other drug therapy makes a causative relationship unlikely. All were infected with Pseudomonas aeruginosa. A role for the infecting organism or drug synergism in contributing to the renal disease cannot be excluded.
D000208:Acute Disease; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D004357:Drug Synergism; D005839:Gentamicins / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008802:Mezlocillin / Q000009:adverse effects* / Q000627:therapeutic use; D009254:Nafcillin / Q000009:adverse effects* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis; D011552:Pseudomonas Infections / Q000188:drug therapy
D005839:Gentamicins; D009254:Nafcillin; D003404:Creatinine; D008802:Mezlocillin