Role of the delta 8 double bond of agroclavine in lysergic acid amide biosynthesis by Claviceps purpurea.
Agroclavine, given to actively-growing sclerotial tissue of a strain of Claviceps purpurea which can not normally elaborate ergot alkaloids, was transformed by this tissue into lysergic acid amide with overall efficiency of approximately 40%. By contrast, festuclavine (8,9-dihydro-agroclavine) was not transformed, indicating specificity in the mechanism of lysergyl biosynthesis.
D002967:Claviceps / Q000378:metabolism*; D004873:Ergolines / Q000378:metabolism*; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives* / Q000378:metabolism; D013329:Structure-Activity Relationship
D004873:Ergolines; C016543:lysergamide; C033546:costaclavin; D008238:Lysergic Acid Diethylamide; C004465:agroclavine