title: Influence of hyposensitization with Dermatophagoides pteronyssinus extract on clinical score, total and specific IgE levels, and skin test in asthmatic patients.
abstract: To evaluate the effects of immunotherapy on clinical response, on IgE serum level, on radioallergosorbent test (RAST), and on skin tests, a prospective study was performed by a follow-up of 73 asthmatic patients allergic for house dust during hyposensitization with Dermatophagoides pteronyssinus extract. No relationship could be found between the evolution of clinical score, skin tests and RAST, but 91% of the patients with a decreasing IgE serum level had satisfactory clinical results. Serial determinations of serum IgE levels during hyposensitization showed two patterns of evolution with a favourable prognostic value: a continuously decreasing serum IgE or a primary increase followed by a late decrease.
mesh_terms: D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000276:immunology*; D003888:Desensitization, Immunologic; D004391:Dust; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D012882:Skin Tests
chemical_list: D000485:Allergens; D004391:Dust; D007073:Immunoglobulin E