title: Rhinocerebral mucormycosis with internal carotid occlusion: report of two cases and review of the literature.
abstract: Two fatal cases of rhinocerebral mucormycosis with fungal invasion and occlusion of the internal carotid artery are described. Review of the literature reveals 35 similar cases of whom only 6 survived. Emphasis is placed on the need for early diagnosis and prompt therapy which consists of correction of the underlying disease, aggressive surgical debridement, and amphotericin B.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D002340:Carotid Artery Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D003646:Debridement; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009668:Nose Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D009916:Orbital Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery
chemical_list: D000666:Amphotericin B