[Collapse of the blood-aqueous humor barrier following laser injury--preventive pharmacotherapy with prostaglandin inhibitors].
Laser-induced collapse of the blood-aqueous barrier and the protective effect of different prostaglandin inhibitors were investigated in the animal study reported here. As a parameter of the barrier function, the protein concentration in the aqueous humor was measured using a micromethod. The anterior chamber of 90 eyes (45 rabbits) was tapped only once, 100 min after the laser procedure. The results prove that different prostaglandin inhibitors in a systemic or topical application form can effectively reduce disturbances of the blood-aqueous barrier after laser surgery. This is also of clinical relevance with regard to laser iridotomy or trabeculoplasty in glaucoma.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D001798:Blood Proteins / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D007834:Lasers; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011817:Rabbits
D001798:Blood Proteins; D011448:Prostaglandin Antagonists; D003907:Dexamethasone; D001241:Aspirin; D007213:Indomethacin
Der Zusammenbruch der Blut-Kammerwasser-Schranke nach Lasertrauma--prophylaktische Pharmakotherapie mit Prostaglandin-Hemmsubstanzen.