[Estimation of the parameters of the single-locus diallele model of qualitative trait in groups of relations].
The method of estimation of parameters of monolocus diallele model (MDM) of qualitative trait on relative group data is described, these parameters being the number of affected and normal proband relatives of the arbitrary family degree and siblings in different matings types. For the case of single ascertainment, the expressions of corresponding probabilities have been taken as functions of MDM parameters using ITO matrixes and genetic transition matrix. Estimation of parameters was obtained by the maximum likelyhood method. Hardy-Weinberg equilibrium is not always necessary for this method; some weak requirement of stationarity is quite enough.
D000483:Alleles; D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D008957:Models, Genetic; D011336:Probability
Otsenivanie parametrov monolokusnoĭ diallel'noĭ modeli kachestvennogo priznaka po gruppam rodstvennikov.