[Effect of vasopressin and oxytocin on the spontaneous activity of dorsal horn cells of the isolated spinal cord of the rat pup].
The effect of vasopressin and oxytocin on background frequency of single cells from the dorsal horn was studied in the isolated spinal cord of 2-3 weeks old rats. It was shown that neurons were predominantly depressed following application both of vasopressin or oxytocin. Vasopressin evoked depression of background activity in 74% cells (29 of 39 responding to vasopressin) and activation in 26% cells (10 from 39). Oxytocin evoked depression in 67% (14 from 21 responding to oxytocin) and activation in 33% cells (7 from 21). All effects were reversible and dose-dependent. Neurons studied either gave the same response both to vasopressin and to oxytoxin or responded only to one of the two peptides.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives*; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects*
D001127:Arginine Vasopressin; D010121:Oxytocin; C025161:vasopressin, deamino-homo-Arg-; D003894:Deamino Arginine Vasopressin
Vliianie vazopressina i oksitotsina na fonovuiu aktivnost' kletok dorsal'nogo roga izolirovannogo spinnogo mozga krysiat.