title: Effects of dexamethasone on phospholipase activities in palate mesenchyme cells in vitro.
abstract: Treatment of primary cultures of palate mesenchyme cells from AJAX strain embryos with dexamethasone inhibited only phospholipase activity expressed at pH 7.5. A similar treatment did not have such an effect on palate mesenchyme cells from C57BL/6J strain embryos. Since the AJAX strain embryo is sensitive to the induction of cleft palate by exogenous glucocorticoids and the C57BL/6J strain is less so, these data allow consideration of phospholipase activity as a site of regulation for development of the palate.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D051379:Mice / Q000196:embryology / Q000378:metabolism; D008815:Mice, Inbred Strains; D010159:Palate / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D003907:Dexamethasone; D010740:Phospholipases