Promotion of sprouting and synaptogenesis of cerebrofugal fibers by ganglioside application in the red nucleus.
The effect of gangliosides on sprouting of cerebrorubral synapses from the contralateral cerebral cortex was investigated following lesions of normal ipsilateral cerebrorubral synapses. It was found that, in cats in which ipsilateral cerebral ablations were performed at more than 2 months of age, the mean probability of occurrence of EPSPs induced in red nucleus neurons by stimulation of fibers from the contralateral cerebral cortex in the ganglioside-treated group was significantly higher than in the untreated group. Therefore, ganglioside application appears to promote sprouting and formation of functional synapses in the red nucleus.
D000818:Animals; D001369:Axons / Q000502:physiology; D002415:Cats; D002417:Cattle; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D005732:Gangliosides / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D012012:Red Nucleus / Q000502:physiology*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D005732:Gangliosides