Inhibitory effects of chlorpromazine on Candida species.
Chlorpromazine was tested for antifungal activity by using Candida albicans and standard assays. The MIC of chlorpromazine was 35 micrograms/ml; the minimal fungicidal concentration was also 35 micrograms/ml. The minimal effective concentration was 2.2 to 3.5 micrograms/ml (using assays based on quantitative cultures and growth). There was a slight positive interaction between chlorpromazine and amphotericin B but no interaction between chlorpromazine and rifampin. Chlorpromazine also inhibited C. krusei, C. parapsilosis, C. tropicalis, and Torulopsis glabrata. We conclude that phenothiazines have direct anti-Candida activity and that these drugs appear to have a broad antimicrobial spectrum.
D000666:Amphotericin B / Q000494:pharmacology; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002746:Chlorpromazine / Q000494:pharmacology*; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000494:pharmacology; D013997:Time Factors
D000666:Amphotericin B; D002746:Chlorpromazine; D012293:Rifampin