The effect of glucagon on N-acetylglutamate-synthetase.
The effect of glucagon and the protein content of the diet on the activity of N-acetylglutamate synthetase was studied. The activity of N-acetylglutamate synthetase depended on the protein content of the diet. Glucagon increased the activity of N-acetylglutamate synthetase and reduced the stimulatory effect of arginine. The enzyme of glucose-fed animals became arginine independent. It was concluded that glucagon induced some kind of covalent modification of the synthetase.
D000123:Acetyltransferases / Q000378:metabolism*; D051046:Amino-Acid N-Acetyltransferase; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013367:Submitochondrial Particles / Q000201:enzymology
D001786:Blood Glucose; D004044:Dietary Proteins; D005934:Glucagon; D000123:Acetyltransferases; D051046:Amino-Acid N-Acetyltransferase