Activation of mitochondrial glycerol 3-phosphate dehydrogenase by cadmium ions.
Mitochondrial glycerol 3-phosphate dehydrogenase (EC 1.1.2.1.) requires Ca2+ ions for its activity. Cadmium ions also have activatory effect on the enzyme. They activate the glycerol 3-phosphate dehydrogenase in a very narrow concentration range (1-2 mmol/l). As contrasted with calcium, strong inhibitory effect occurred at higher concentrations (3-4 mmol/l). The inhibition induced by cadmium ions was completely reversible by washing of the mitochondria.
D002001:Adipose Tissue, Brown / Q000201:enzymology*; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005993:Glycerolphosphate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D010084:Oxidation-Reduction
D002104:Cadmium; D005993:Glycerolphosphate Dehydrogenase; D002118:Calcium