title: Uric acid levels in plasma and urine in rats chronically exposed to inorganic As (III) and As(V).
abstract: The effect of inorganic arsenic (III) and arsenic (V) on renal excretion and plasma levels of uric acid was examined in rats. Oral administration of 1200 micrograms As/kg/day for 6 weeks diminished uric acid levels in plasma by 67.1% and 26.5% of control after the administration of As(III) and As(V), respectively. Renal excretion of uric acid was significantly reduced during the first 3 weeks following As (III) administration, with a subsequent increase to approach control values at the end of the treatment. When As(V) was administered, the diminution in renal excretion was significant at 6 weeks.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014527:Uric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D014527:Uric Acid; D001151:Arsenic