Pharmacological profile of 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2-imidazolidinone (Go-10213), a new antiprotozoal agent, in comparison with metronidazole.
A new antiprotozoal agent, 1-methylsulphonyl-3-(1-methyl-5-nitro-2-imidazolyl)-2-imidazolidinone (Go-10213) has a distinct advantage over metronidazole when their respective neuropharmacological effects on central and peripheral nervous functions are compared in different animal species. The results show that at equivalent dosage schedules with repeated high dosages, Go-10213 is devoid of adverse central and peripheral neural effects in monkeys; cats and dogs, whereas unequivocal evidence of metronidazole neurotoxicity was obtained in all the three species. Go-10213 compares favourably with metronidazole in animal tests for cardiovascular tolerability.
D000818:Animals; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D004562:Electrocardiography; D004569:Electroencephalography; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D066298:In Vitro Techniques; D008253:Macaca mulatta; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D009593:Nitroimidazoles / Q000494:pharmacology*; D051381:Rats
D000994:Antitrichomonal Agents; D009593:Nitroimidazoles; D008795:Metronidazole; D000431:Ethanol; C034473:satranidazole; D008635:Mescaline