title: Benign isolated histiocytosis mimicking chicken pox in a neonate: report of two cases with ultrastructural study.
abstract: Two cases of benign isolated cutaneous histiocytosis X in newborn infants are reported. Clinically, the lesions mimicked chicken pox, and the histologic findings in skin biopsies were indistinguishable from those described in infantile Letterer-Siwe disease. Electron microscopy showed Langerhans' cells with the classical trilaminar, racket-shaped granules. Our cases a well as 10 of the 21 previously reported cases showed spontaneous resolution of the skin lesions. Since this is a benign spontaneous resolving histiocytosis, we recommend that no therapy be given provided that no other signs of systemic involvement are found.
mesh_terms: D001706:Biopsy; D002644:Chickenpox / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D007231:Infant, Newborn; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology / Q000648:ultrastructure