[Effect of unithiol on the ultrastructure of the myocardium and adrenals in endotoxin shock].
Administration of unithiol to animals with endotoxin shock promotes deposition of catecholamines in chromaffin cells of the adrenals, blocks their secretion to the bloodstream and prevents the development of injuries to the cortical substance of the gland. Administration of unithiol for endotoxemia prevents damage to intracellular organelles of cardiomyocytes. However, insignificant disorders of the contractile apparatus of the cells and histohematic barriers are maintained. The capacity of unithiol to prevent the progress of destructive alterations in the heart and adrenals permits recommending it for use in combined treatment of septic conditions.
D000311:Adrenal Glands / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000187:drug effects*; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D012772:Shock, Septic / Q000188:drug therapy* / Q000473:pathology; D014494:Unithiol / Q000627:therapeutic use*
D004112:Dimercaprol; D014494:Unithiol
Vliianie unitiola na ul'trastrukturu miokarda i nadpochechnikov pri éndotoksinovom shoke.