title: Treatment of mouse carcinomas with intratumoral injections of hematoporphyrin derivative and red light.
abstract: Hairless mice with subcutaneously transplanted Lewis Lung carcinomas were used to study the effects of treatments with hematoporphyrin derivative (HPD) administered by intratumoral injection, followed by exposure to red light. A tumor cure rate of 70-90% was obtained following a single treatment. The therapeutic response increased with increasing HPD doses and light fluences. At a certain dose a plateau seemed to be reached, where further dose increase only gave a limited gain in treatment response. A narrow range seems to exist between beginning therapeutic response and frank necrotic destruction. The number of mice that died after treatment increased with increase in tumor size, and there was a correspondence between the time of death and the severity of the phototoxic reactions. The best therapeutic response was obtained when the irradiation was performed 1/2-1 h after injection, and with tumors less than 6-8 mm in diameter.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006415:Hematoporphyrins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D008812:Mice, Hairless; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D006415:Hematoporphyrins