title: Primary lymphedema of the leg: relationship between subcutaneous tissue pressure, intramuscular pressure and venous function.
abstract: In eight patients with unilateral primary lymphedema, subcutaneous tissue and intramuscular pressure were measured in both legs using the slit-catheter technique. Venous function was assessed by venography, or Doppler or photoplethysmography. Both at rest and during exercise, subcutaneous tissue pressure was elevated in the lymphedematous leg (17.9 +/- 7.6 and 33.0 +/- 10.8 mmHg respectively) compared to healthy contralateral leg (0.4 +/- 2.6 and -0.6 +/- 3.6 mmHg; p less than 0.001). The intramuscular pressure in the anterior tibial compartment was also increased at rest and during exercise in the edematous leg (24.9 +/- 4.4 mmHg and 43.6 +/- 11.2 mmHg respectively) compared to control leg (9.6 +/- 5.6 and 25.8 +/- 10.00 mmHg). These findings suggest that derangements in both the superficial and deep lymphatic systems as well as venous dysfunction contribute to the clinical appearance of "primary lymphedema."
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D007866:Leg; D008209:Lymphedema / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply / Q000503:physiopathology; D009997:Osmotic Pressure; D005082:Physical Exertion; D011817:Rabbits; D014680:Veins