[Interference between anthelmintics and immunity in gastrointestinal strongylosis of sheep].
Groups of very similar sheep (breed, sex, age, hemoglobin type, family) were immunised against H. contortus by repeated infections. Self-cure and immune reactions expelled parasites but some of them still remain in the gut of animals; they have been eliminated by dosage of anthelmintics. Animal were challenged; a discrepancy exists between numbers of eggs passed in each group (immune and dosed animals, immune and non-dosed animals and non-immune animals); the best fitting estimated equation on experimental values (or on moving average points) is used for statistical tests. Immunity vanishes partly (or totally) when animals have been dosed; a residual population of worms is thought to be responsible for immunity because of a permanent booster.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005260:Female; D006188:Haemonchiasis / Q000188:drug therapy / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects / Q000276:immunology; D007411:Intestinal Diseases, Parasitic / Q000662:veterinary*; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D000871:Anthelmintics
Interférence entre vermifugation et immunité dans les strongyloses gastro-intestinales du mouton.