Ventral rhizotomy enhances regeneration of uninjured sensory neurons.
Uninjured sensory neurons show metabolic and morphologic changes, as well as enhanced regeneration, when exposed to adjacent degenerating ventral root fibers. The release of a neurotrophic factor from the degenerating nerve fibers may be responsible for 'priming' the uninjured neuron and thereby enhancing its response to injury.
D000818:Animals; D005260:Female; D006984:Hypertrophy; D009414:Nerve Growth Factors; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010525:Peripheral Nerves / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000293:injuries*
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins