The role of central noradrenergic neurons in electroconvulsive shock-induced muricide inhibition in olfactory bulbectomized rats.
In order to elucidate the role of central monoaminergic neurons in electroconvulsive shock (ECS)-induced muricide inhibition in the olfactory bulbectomized rat (OB rat), we examined the effect of chemical or electrical lesions of each monoamine-containing neuron on ECS-induced muricide inhibition. ECS-induced muricide inhibition was antagonized by 6-hydroxydopamine (6-OHDA) treatment and locus coeruleus lesions, while it was unaffected by desipramine + 6-OHDA, substantia nigra lesion, and desipramine + 5,7-dihydroxytryptamine. The present results strongly suggest that ECS-induced muricide inhibition of the OB rat is due to increased activity of the noradrenaline but not of dopamine and serotonin neurons.
D000320:Adrenergic Fibers / Q000502:physiology; D000374:Aggression / Q000502:physiology*; D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004597:Electroshock; D006801:Humans; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D009830:Olfactory Bulb / Q000502:physiology*; D011235:Predatory Behavior / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D013378:Substantia Nigra / Q000502:physiology
D009638:Norepinephrine