title: [Effect of cimetidine on maximal stomach secretion in physical stress and at rest in patients with chronic duodenal ulcer].
abstract: In 21 males suffering from chronic duodenal ulcers the effect of cimetidine on the maximum acid output (MAO) both in rest and under physical load was examined. Patients were loaded two times (60 min) with the Monark bicycle ergometer at an interval of 5-7 days. Immediately before second examination cimetidine was injected intravenously (6 mg/kg body weight). The sampling of gastric juice was done 3 times for 60 min before, during and after the physical work. In the stimulated gastric fluid the concentrations of sodium, potassium, chlorid ions, total protein and mucoproteins were checked. In the peripheral venous blood sodium, potassium, chlorid, magnesium and calcium were measured as well as glucose and the parameters of acid base state. Cimetidine significantly reduced ionic concentration, protein and mucoproteid concentrations of the gastric fluid. Cimetidine did not provoke any changes of the parameters determined in the peripheral blood.
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
chemical_list: D002927:Cimetidine
vernacular_title: Der Einfluss von Cimetidin auf die maximale Magensekretion unter körperlicher Belastung und in Ruhe bei Patienten mit chronischem Duodenalulkus.