Rheumatoid factor isotypes following immunization.
Serum from 422 healthy subjects prior to and four weeks after multiple immunizations was studied for rheumatoid factors (RF) by an enzyme-linked immunosorbent assay (ELISA). Increase in IgM RF was detected in 22% of subjects by ELISA, but was not detectable by a standard sheep-cell agglutination test. Immunization may be a cause of RF positivity by a sensitive assay such as ELISA; it is not likely to be detected by standard clinical methods.
D000328:Adult; D005260:Female; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D012217:Rheumatoid Factor / Q000032:analysis*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor