title: [Genetic aspects of the reaction of humoral immunity to collagen in humans and animals. Report I. Analysis of polymorphism of autoantibody levels to collagen type I in mice NZB X NZW (F1)].
abstract: The study of polymorphism of humoral immunoreactions to the type I (AC) collagen in CBA/Lac, C57B1/6-J inbred mice and NZB X NZW (F1) hybrids showed the presence of genetically determined variability of the above mentioned trait. The analysis of intralinear dispersions of AC levels in NZB X NZW (F1) mice revealed sex dimorphism and age variability of the trait. A suggestion was made that sex hormones are important factors in ontogenic formation and modulation of autoimmunity to the type I collagen in NZB X NZW (F1) mice.
mesh_terms: D000367:Age Factors; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis / Q000235:genetics*; D002417:Cattle; D003094:Collagen / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D011110:Polymorphism, Genetic; D012737:Sex Factors; D012867:Skin; D013045:Species Specificity
chemical_list: D001323:Autoantibodies; D003094:Collagen
vernacular_title: Geneticheskie aspekty reaktsiĭ gumoral'nogo immuniteta k kollagenu u cheloveka i zhivotnykh. Soobshchenie I. Analiz polimorfizma urovneĭ autoantitel k kollagenu I tipa u mysheĭ NZB X NZW (F1).