title: Effect of short surgical procedures on salivary paracetamol elimination.
abstract: The effect of short surgical procedures on paracetamol elimination was studied in seven male patients undergoing surgery with epidural anaesthesia. Five healthy volunteers who did not undergo surgery served as a control group. Paracetamol concentration was measured in saliva at various intervals 1 day before and after surgery. Paracetamol half-life (t1/2,z) decreased and metabolic clearance rate (CL) increased after surgery as compared to preoperative values. The results suggest that surgical stress may enhance the hepatic metabolism of paracetamol.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007700:Kinetics; D008297:Male; D012463:Saliva / Q000378:metabolism*; D013514:Surgical Procedures, Operative; D006848:Testicular Hydrocele / Q000601:surgery; D013997:Time Factors
chemical_list: D000082:Acetaminophen