[Nonopiate subarachnoid analgesia induced by GABA-positive substances].
It has been shown in experiments on rats exposed to a gradually increasing nociceptive action that subarachnoidal injection of GABA and its agonists (CHBA) isoguvacin, phenibut) in a dose of 0.6 mg causes an elevation of the thresholds of motor and, to a less degree, of emotional behavioral component of the painful reaction. Analgesia is potentiated by simultaneous subarachnoidal injection of inactive doses of chlorodiazepoxide. The GABA uptake inhibitor guvacin potentiates the effect of isoguvacin. The GABA-and phenibut-induced analgesia is not abolished by nalozone (0.04 mg subarachnoidally).
D000698:Analgesia / Q000379:methods*; D000700:Analgesics; D000818:Animals; D004347:Drug Interactions; D005260:Female; D018756:GABA Antagonists; D007267:Injections; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013346:Subarachnoid Space; D013997:Time Factors; D005680:gamma-Aminobutyric Acid
D000700:Analgesics; D018756:GABA Antagonists; D005680:gamma-Aminobutyric Acid
Neopiatnaia subarakhnoidal'naia anal'geziia, vyzyvaemaia GAMK-pozitivnymi veshchestvami.