[Pain-alleviating action of gidifen and its combinations with analgesics].
The analgesic effect of gidifen, a new tranquilizer belonging to the group of organophosphorus compounds, manifests itself in relatively high doses (1/3 of the LD50). The quantitative characteristics of the analgesic action depends on the method for evaluating the analgesic action of the drug. On combined use of gidifen and analgesics applied in a definite dosage range the analgesic effect is potentiated. If the tranquilizer under study is combined with non-narcotic analgesics, the above potentiation is accompanied with an increase in the toxicity and myorelaxant activity of gidifen. On combination of the latter with morphine the parameters under consideration are unchanged. According to the pattern of interaction with analgesics gidifen does not differ in principle from benzodiazepine tranquilizers. However, the drug is not superior to benzodiazepines in this respect.
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007928:Lethal Dose 50; D051379:Mice; D009020:Morphine / Q000627:therapeutic use; D010146:Pain / Q000188:drug therapy*; D010721:Phosphinic Acids / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D014149:Tranquilizing Agents / Q000627:therapeutic use* / Q000633:toxicity
D000700:Analgesics; D010721:Phosphinic Acids; D014149:Tranquilizing Agents; C025175:gidifen; D009020:Morphine
Izuchenie boleutoliaiushchego deĭstviia gidifena i ego sochetaniĭ s anal'getikami.