Late pulmonary response in guinea pigs after ascaris challenge.
Respiratory resistance of guinea pigs immunized with Ascaris suum was measured over 6 hr after aerosol challenge of the allergen by use of the oscillation method. These animals showed a biphasic pulmonary response to the aerosol challenge with Ascaris suum. Histological analysis of these animals revealed a narrowing of bronchial lumen, peribronchial edema and neutrophil-rich mucous in bronchial lumen at the late pulmonary response.
D000336:Aerosols; D000818:Animals; D001200:Ascaris / Q000276:immunology; D001249:Asthma / Q000503:physiopathology*; D001980:Bronchi / Q000473:pathology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000473:pathology / Q000503:physiopathology*; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D013997:Time Factors
D000336:Aerosols