Effect of simultaneous administration of ibuprofen and ethanol on the alkaline phosphatase activity in the small intestine.
Using the interferometric technique the authors studied the effect of simultaneous administration of ibuprofen (Polfa) and ethanol on the activity of alkaline phosphatase in the proximal jejunum. Both ibuprofen and ethanol cause in the digestive tract functional and morphological changes. The used technique of quantitative determination of alkaline phosphatase activity at the site of its primary location made possible an assessment of changes in the activity of the enzyme caused by the administered agents. It was found that after 60 days of the experiment both agents caused a statistically greater changes were observed in the rats receiving both these agents simultaneously. The obtained results suggest the conclusion that simultaneous administration of ibuprofen and ethanol causes in the mucosal gland in the proximal small intestine development of an interaction of the additive.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D004334:Drug Administration Schedule; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage*; D007052:Ibuprofen / Q000008:administration & dosage*; D007413:Intestinal Mucosa / Q000201:enzymology*; D007441:Intubation, Gastrointestinal; D007583:Jejunum / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D000469:Alkaline Phosphatase; D007052:Ibuprofen