title: CC-1065 transformations.
abstract: This report defines the transformations that antitumor antibiotic CC-1065 underwent under basic and acidic conditions. The isolation, purification, characterization, and biological properties of a cyclopropapyrroloindole fragment, and an acidic fragment, PDE-I dimer, from a mild alkaline fragmentation and the phenolic product, AAP, resulting from alkylation of acetic acid by the cyclopropyl function are described.
mesh_terms: D000903:Antibiotics, Antineoplastic; D002942:Circular Dichroism; D000080890:Duocarmycins; D007211:Indoles; D007933:Leucomycins; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000903:Antibiotics, Antineoplastic; D000080890:Duocarmycins; D007211:Indoles; D007933:Leucomycins; C018782:CC 1065