Multipotentiality of yolk-sac carcinoma cell clones.
Yolk-sac carcinoma (YSCa) clones were isolated by manual cloning under visual control. By morphology, immunohistology and histochemistry the clones were shown to differentiate in vitro into visceral and parietal yolk-sac cells and in vivo into visceral and parietal yolk-sac cells, trophoblast and mesenchyme. Trophoblast and mesenchyme were only recorded in rat YSCa derived from displaced yolk sac but not in embryo-derived YSCA. Hence YSCa cells displaying a visceral and parietal yolk-sac pattern as well as the trophoblastic and the mesenchymal structures should have a common cell ancestor.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002454:Cell Differentiation; D002460:Cell Line; D002999:Clone Cells / Q000473:pathology; D008649:Mesonephroma / Q000473:pathology*; D051381:Rats; D014327:Trophoblasts / Q000473:pathology
D000911:Antibodies, Monoclonal