[Amplification of nucleotide sequences homologous to the viral myc oncogene in DNA of colonic mucosa in a patient with cancer of the same location].
Genomic DNA of intact colonic mucosa obtained from a female patient suffering colonic cancer revealed amplified nucleotide sequences (multiple copies) related to viral myc oncogene. The study failed to detect amplification in tumor. Causation and pathways of the event are discussed.
D001483:Base Sequence; D003106:Colon / Q000648:ultrastructure*; D003110:Colonic Neoplasms / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007413:Intestinal Mucosa / Q000648:ultrastructure; D009857:Oncogenes
D004273:DNA, Neoplasm
Amplifikatsiia nukleotidnykh posledovatel'nosteĭ, gomologichnykh virusnomu onkogenu myc v DNK slizistoĭ obolochki tolstogo kishechnika u bol'noĭ s kartsinomoĭ toĭ zhe lokalizatsii.