Examination of the bronchoconstrictor response of guinea-pig isolated lung to beta-phenylethylamine.
beta-Phenylethylamine (PEA) produced a contraction of the guinea-pig isolated lung parenchymal strip and bronchoconstriction of perfused lungs. Reserpine pretreatment had little effect on these responses indicating a substantial direct effect. Phentolamine (10(-6) and 10(-5) M) had minimal effect on PEA in the lung strip compared with that on noradrenaline, eliminating involvement of alpha-adrenoceptors. PEA was unaffected by atropine (10(-7)M) or a mepyramine (10(-7)M); metiamide (10(-4)M) mixture. The contraction was not therefore mediated via muscarinic or histaminergic receptors. 5-HT and dopamine receptors were also discounted. Possible stimulation of a phenylethylaminergic receptor and its relevance to bronchial asthma is discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D008168:Lung / Q000502:physiology*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D008785:Metiamide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D008785:Metiamide; D001285:Atropine; D006632:Histamine; D002217:Carbachol; D011433:Propranolol; D011738:Pyrilamine; D004298:Dopamine; D009638:Norepinephrine; D008784:Methysergide; D010646:Phentolamine