Non-invasive investigations of the growth kinetics of a solid experimental tumor (sarcoma-180).
The investigations reported were performed to test applicability of non-invasive methods for the measurement of the parameters determining the growth of a solid experimental tumor and to measure these data for the tumor system sarcoma-180/NMRI-mice. It could be shown that non-invasive methods can be used for the measurement of tumor growth, especially the fraction of proliferating cells (growth fraction) which is of special importance for tumor therapy. For the tumor system under investigation, the growth is completely determined by an exponential decrease of the growth fraction.
D000818:Animals; D001345:Autoradiography; D002453:Cell Cycle; D004273:DNA, Neoplasm / Q000378:metabolism; D003857:Deoxyuridine; D005260:Female; D007457:Iodine Radioisotopes; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000503:physiopathology*; D013997:Time Factors
D004273:DNA, Neoplasm; D007457:Iodine Radioisotopes; D003857:Deoxyuridine