Myotrophic effects on denervation atrophy of hindlimb muscles of mice with systemic administration of nerve extract.
Atrophy was assessed in denervated hindlimb muscles of adult mice which either were not otherwise treated or received daily intraperitoneal injections of extract of rats' sciatic nerves. After 7 days, the denervated muscles of injected animals exhibited significantly smaller decreases in wet weight, total protein and cross-sectional areas of muscle fibers relative to innervated contralateral control muscles. The effects of denervation and nerve extract on different muscles varied.
D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009121:Muscle Denervation / Q000009:adverse effects; D009133:Muscular Atrophy / Q000209:etiology / Q000517:prevention & control*; D009928:Organ Specificity; D010525:Peripheral Nerves; D014020:Tissue Extracts / Q000627:therapeutic use*
D014020:Tissue Extracts