Reversibility of reduced mucociliary clearance in chronic sinusitis.
Nasal mucociliary clearance was measured before and after treatment in patients with chronic sinusitis. Nasal mucociliary transit time before the study was greater than 36 min in 8 out of 14 patients who were treated with S-carboxymethylcysteine, and in 9 out of 22 patients who were treated by repeated antral lavage. The nasal mucociliary clearance was significantly improved by both treatment regimens. This may indicate that the malfunction of the nasal mucociliary system is not the cause of chronic sinusitis but an effect of chronic inflammation of the respiratory mucosa.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport; D002233:Carbocysteine / Q000627:therapeutic use; D002908:Chronic Disease; D002923:Cilia / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009093:Mucus / Q000378:metabolism*; D009297:Nasal Mucosa / Q000503:physiopathology*; D012852:Sinusitis / Q000503:physiopathology* / Q000628:therapy; D007507:Therapeutic Irrigation
D002233:Carbocysteine