Phylogenetic examination of vertebrate central nervous system myelin proteins by electro-immunoblotting.
Central nervous system (CNS) myelin proteins from vertebrate classes were examined by immunoblotting with antisera against mammalian CNS myelin proteins. Higher vertebrates possessed proteolipid (PLP), DM-20 and Wolfgram (WP) proteins, except that DM-20 was missing in amphibia. Fish CNS myelins contained neither PLP nor WP; instead they bound antisera to mammalian peripheral nervous system P0 protein. All classes carried myelin basic protein, but only mammals exhibited a component equivalent to rat 21.5K (21,500 dalton). These phylogenetic data are consistent with major changes in CNS myelin protein composition at the transition from fishes to higher vertebrates.
D000818:Animals; D001001:Anura; D001923:Brain Chemistry; D002645:Chickens; D006801:Humans; D008116:Lizards; D009185:Myelin Proteins / Q000032:analysis*; D051381:Rats; D013045:Species Specificity; D013552:Swine; D014101:Torpedo; D014337:Trout
D009185:Myelin Proteins