Effect of GABA-T inhibitors on prolactin secretion in vitro.
A study was made of the effect of GABA-transaminase (GABA-T) inhibitors on the in vitro release of prolactin by pituitaries of male and female rats. Aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG) added to the incubation medium decreased prolactin release from both male and female rat pituitaries. Additive effects on prolactin release were only observed when male rat pituitaries were incubated with AOAA plus GABA. Prolactin concentration in the pituitary gland was also decreased by AOAA in both sexes. The present results lend support to the idea of an inhibitory action of GABA on prolactin release by the pituitary gland.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010052:Ovariectomy; D010902:Pituitary Gland / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000480:Alkynes; D000614:Aminocaproates; D000625:Aminooxyacetic Acid; C013785:4-amino-5-hexynoic acid; D011388:Prolactin; D000612:4-Aminobutyrate Transaminase