Hormonal effects on the estrogen receptor system in the epididymis and accessory sex organs of sexually immature rabbits.
The epididymis and male accessory sex organs (vesicular gland, prostate, and bulbourethral gland) of sexually immature rabbits contain a functional estrogen receptor system which is regulated in an organ-specific manner by various hormones. In both intact and castrated animals, acute estrogen challenge causes depletion of estrogen receptor from the cytosolic fraction and its appearance in the nuclear fraction of these tissues. A considerable amount of unoccupied nuclear receptor was detected both before and after estrogen challenge. An estrogen-activated, receptor-processing mechanism is operable in these organs since chronic treatment (daily for 14 days) with estradiol benzoate modified the levels of total estrogen receptor, and altered the relative amounts of occupied to unoccupied nuclear receptor present following estrogen challenge. Chronic treatment with estradiol benzoate, Tamoxifen, and testosterone propionate (alone and in combination) had differential, organ-specific effects on the ability of subsequent estrogen challenge to cause accumulation of nuclear receptor. The vesicular gland was the most responsive to estrogen treatment and the bulbourethral gland the least responsive.
D000728:Androgens / Q000097:blood; D000818:Animals; D002369:Castration; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism*; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005837:Genitalia, Male / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology*; D014018:Tissue Distribution
D000728:Androgens; D011960:Receptors, Estrogen; D013629:Tamoxifen; D013739:Testosterone; D004958:Estradiol