Testosterone secretion is severely impaired after hepatectomy in rat, dog and man.
In 90%-hepatectomized rats, the plasma testosterone level (0.34 +/- 0.07 ng.ml, mean +/- SEM) is significantly lower (P less than 0.001) than in sham operated male rats (1.7 +/- 0.26 ng.ml, mean +/- SEM). In dogs, after 90% hepatectomy, the mean plasma testosterone concentration fell to 1/10 of the plasma testosterone level measured in sham operated animals either 24 or 72 h after surgery. In hepatectomized men, plasma testosterone is markedly decreased in contrast to what is observed after duodeno-pancreatectomy performed under the same conditions of anesthesia. These results suggest that 90% hepatectomy severely alters the Leydig cell function.
D000818:Animals; D003345:Corticosterone / Q000097:blood; D004285:Dogs; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D007700:Kinetics; D007985:Leydig Cells / Q000502:physiology; D008297:Male; D008875:Middle Aged; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D003345:Corticosterone