Efficacy of ipronidazole against trichomoniasis in beef bulls.
Preputial smegma samples from 195 beef bulls were collected repeatedly and cultured for Tritrichomonas foetus. Seventy-five (38.5%) of these bulls were positive for trichomonads on at least 1 culture. Sensitivity of the culture procedure (number of positive cultures/number of total cultures from known-positive bulls) was 81.6%. Storage of preputial smegma in lactated Ringer's solution at 5 C for 24 hours resulted in a 14% loss of sensitivity. Seventy-three of the 75 infected bulls were available for treatment and were alloted randomly to 2 groups. Bulls in both groups were treated with procaine penicillin (7,000 IU/kg, IM) for 2 days before ipronidazole treatment. Thirty grams of ipronidazole powder was dissolved in 60 ml of sterile water, and was given IM to group 1 bulls. Group 2 bulls were given a similar 30-g ipronidazole solution IM on day 1, and were given 15 g of ipronidazole dissolved in 30 ml of sterile water on days 2 and 3. Efficacy of treatment (ie, negative cultures of preputial smegma for trichomonads for 6 consecutive weeks after treatment) was 92.8% for the 42 bulls treated once and 100% for the 31 bulls treated 3 times.
D000818:Animals; D002140:California; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000188:drug therapy*; D003470:Culture Media; D007491:Ipronidazole / Q000627:therapeutic use*; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D012902:Smegma / Q000469:parasitology; D014244:Trichomonas / Q000302:isolation & purification; D014245:Trichomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*
D003470:Culture Media; D009593:Nitroimidazoles; D007491:Ipronidazole