Resistance to competitive neuromuscular blocking agents in burn patients: a review.
The quantitative and qualitative aspects of the phenomenon of resistance to competitive (non-depolarizing) neuromuscular blocking agents in burn patients are described. The correlates and temporal features of this resistance are discussed, in addition to therapeutic approaches and the possible mechanisms underlying the resistance.
D000367:Age Factors; D000443:Alcuronium / Q000627:therapeutic use; D001798:Blood Proteins / Q000378:metabolism; D002056:Burns / Q000188:drug therapy* / Q000503:physiopathology; D002118:Calcium / Q000502:physiology; D002802:Cholinesterases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D006801:Humans; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D009467:Neuromuscular Depolarizing Agents / Q000627:therapeutic use*; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D014403:Tubocurarine / Q000031:analogs & derivatives / Q000627:therapeutic use
D001798:Blood Proteins; D009467:Neuromuscular Depolarizing Agents; D002802:Cholinesterases; D010197:Pancuronium; D000443:Alcuronium; D002118:Calcium; C032943:metocurine; D014403:Tubocurarine