Adrenalectomy attenuates stimulation-produced analgesia.
Ablation of the adrenal glands potentiates analgesia induced by morphine and attenuates an opioid form of stress-induced analgesia. the adrenal cortex has been implicated in analgesia induced by morphine and enkephalin-like peptides in the adrenal medulla have been suggested to modulate stress-induced analgesia. The effect of adrenalectomy upon analgesia produced by stimulation of the brain has not been investigated. The present investigations demonstrated that antinociception (measured with the tail-flick test) from focal stimulation of the periaqueductal grey was attenuated or abolished after adrenal ablation. These results implicate adrenal hormones in the regulation of the endogenous pain inhibitory system in the brain.
D000315:Adrenalectomy; D000698:Analgesia; D000818:Animals; D001921:Brain / Q000502:physiology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time