Timing of combined hyperthermia and 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-diamminedichloroplatinum in BD IX rats with BT4A tumours.
Groups of 7-10 evaluable BD IX rats with the neurogenic BT4A tumour on the right hind leg were treated with waterbath hyperthermia (44 degrees C, 60 min) in combination with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) 20 mg/kg or cis-diamminedichloroplatinum (cis-DDP) 3 mg/kg i.p. at different sequences and timing within +/- 24 hr. Tumour responses were evaluated by tumour doubling time and clinical criteria, toxicity by toxic deaths, weight loss, and local skin reactions. With both BCNU and cis-DDP, tumour response was markedly dependent on timing; the greatest effects were obtained giving hyperthermia just after the drug. Local side effects were not different in the timing groups, but cis-DDP general toxicity was most severe when cis-DDP was given just before hyperthermia.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000628:therapy*; D002330:Carmustine / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000009:adverse effects; D006979:Hyperthermia, Induced; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000628:therapy; D013997:Time Factors
D002945:Cisplatin; D002330:Carmustine