Role of free radical scavengers on phenylhydrazine induced hemolysis in rat.
The mechanism of the phenylhydrazine induced oxidative hemolysis was studied on the point of role of the free radical scavengers in rats. Phenylhydrazine resulted in the degradation of hemoglobin and the lipid peroxidation of the erythrocyte membrane. Otherwise, the elevation of coenzyme Q9, endogenous CoQ in rats, levels in plasma was observed against the phenylhydrazine induced oxidative stress. Supplementation of coenzyme Q10, exogenous CoQ in rats, inhibited the phenylhydrazine induced hemolysis according to the suppression of both the degradation of hemoglobin and the lipid peroxidation of the erythrocyte membrane. These results suggest that free radical scavengers such as coenzyme Q9 and coenzyme Q10 have important roles on the phenylhydrazine induced hemolysis in rats.
D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005609:Free Radicals; D006400:Hematocrit; D006461:Hemolysis / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008706:Methemoglobin / Q000032:analysis; D010659:Phenylhydrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014451:Ubiquinone / Q000097:blood / Q000494:pharmacology; D014810:Vitamin E / Q000097:blood
D005609:Free Radicals; D008054:Lipid Peroxides; D010659:Phenylhydrazines; C030299:phenylhydrazine; D014451:Ubiquinone; D014810:Vitamin E; D008706:Methemoglobin