title: Temperature effects on the binding efficiency of starch pastes.
abstract: The effect of temperature on the binding efficiency of yam starch and cassava starch pastes has been investigated. Starch pastes prepared at different temperatures were used to granulate lactose powder and the resulting granules and tablet properties were evaluated. Increased average granule size and decreased percentage fines were observed as the pasting temperature was increased upto a certain level and then there was a decrease in average size and increase in amount of fines as the pasting temperature was further increased. Granules prepared with yam starch pastes exhibited relatively lower amount of fines and larger average granule size. The corresponding tablets also showed higher crushing strength values and were less friable. Although the disintegration time of tablets was found to increase with the temperature of pasting of both the starches, no relationship between the pasting temperature and the crushing strength of tablets was observed. The release of amylose/amylopectin from starch grains, the amylopectin chain length and the amount of free molecular components as the pasting temperature increased are believed to be the factors contributing to the increased binding efficiency of the starch pastes.
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients; D005782:Gels; D010316:Particle Size; D012995:Solubility; D013213:Starch; D013607:Tablets; D013696:Temperature
chemical_list: D005079:Excipients; D005782:Gels; D013607:Tablets; D013213:Starch