In vitro 16 alpha-hydroxylation of progesterone by testes of crab-eating monkey (Macaca irus): a characteristic of primates?
Radioactive 16 alpha-hydroxyprogesterone was obtained as one of the major metabolites of [14C]pregnenolone and progesterone by testicular homogenates of an adult crab-eating monkey (Macaca irus). 16 alpha-hydroxylation of progesterone occurred by incubation of testes of men and and the monkey, but not by those of rodents and other vertebrates examined.
D000818:Animals; D003460:Crystallization; D006801:Humans; D006900:Hydroxylation; D006908:Hydroxyprogesterones / Q000096:biosynthesis*; D008251:Macaca; D008297:Male; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism*; D013045:Species Specificity; D039181:Steroid 16-alpha-Hydroxylase; D013737:Testis / Q000378:metabolism*
D006908:Hydroxyprogesterones; C018975:16-hydroxyprogesterone; D011374:Progesterone; D011284:Pregnenolone; D039181:Steroid 16-alpha-Hydroxylase