title: Aminoglutethimide-induced hematologic toxicity: worldwide experience.
abstract: Marked leukopenia and/or thrombocytopenia occurred in 12 of 1333 patients treated with aminoglutethimide (0.9% incidence). Depression of blood cell counts was evident within 7 weeks of starting treatment. No delayed toxicity was encountered. Blood cell counts recovered promptly upon cessation of aminoglutethimide in all but one patient, who died from septicemia and marrow aplasia.
mesh_terms: D000616:Aminoglutethimide / Q000009:adverse effects*; D001772:Blood Cell Count; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D014943:Global Health; D006402:Hematologic Diseases / Q000139:chemically induced*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors
chemical_list: D000616:Aminoglutethimide