[Synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with special consideration of the bronchospasmolytic (-)-N-ethylnorscopolamine methobromide (Ba 253 BR)].
The synthesis of anticholinergic N-alkylnorscopolamines and their quaternary salts, especially the synthesis of (-)-N-ethylnorscopolamin methobromide (Ba 253 BR), is reported. (-)-N-Ethylnorscopolamine methobromide differs from the stereoisomeric (-)-N-ethylscopolammonium bromide not only by its physico-chemical, but also by its pharmacological properties. (-)-N-Ethylnorscopolamine methobromide represents an anticholinergic bronchodilator with long duration of action.
D000478:Alkylation; D000818:Animals; D001993:Bronchodilator Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D003640:Dealkylation; D010084:Oxidation-Reduction; D010276:Parasympatholytics / Q000138:chemical synthesis*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis; D012601:Scopolamine; D012602:Scopolamine Derivatives / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001993:Bronchodilator Agents; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; D012602:Scopolamine Derivatives; C017590:oxitropium; D012601:Scopolamine
Synthese von anticholinerg wirksamen N-Alkylnorscopolaminen und deren Quartärsalzen unter besonderer Berücksichtigung des Bronchospasmolytikums (-)-N-Ethylnorscopolamin-methobromid (Ba 253 BR).