Methionine-enkephalin inhibits stress-induced increases in noradrenaline turnover in brain regions of rats.
Met-Enkephalin injected i.c.v. attenuated stress-induced increases in levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate, the major metabolite of brain noradrenaline, in the hypothalamus, amygdala, hippocampus, thalamus, midbrain and LC region in rats. The data suggest that Met-enkephalin acts to attenuate stress-induced increases in noradrenaline turnover in these brain regions in rats.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D008734:Methoxyhydroxyphenylglycol; D004744:Enkephalin, Methionine; D009638:Norepinephrine