Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid).
A sesquiterpene named koningic acid has been isolated from a strain of Trichoderma koningii as a potent inhibitor of ATP generation in the glycolytic pathway. From experiments with both cultured mouse carcinoma FM3A cells and isolated enzymes, it was shown that koningic acid is a specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase that catalyzes the conversion of glyceraldehyde 3-phosphate to 3-phosphoglycerate.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D005986:Glyceraldehyde 3-Phosphate / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D006019:Glycolysis / Q000187:drug effects*; D007773:Lactates / Q000096:biosynthesis; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012717:Sesquiterpenes / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014242:Trichoderma / Q000378:metabolism
D007773:Lactates; D012717:Sesquiterpenes; D005986:Glyceraldehyde 3-Phosphate; C027285:heptelidic acid; D000255:Adenosine Triphosphate; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D007930:Leucine; D013936:Thymidine