Effect of clofibrate treatment on aconitase activity in rat liver and other tissues.
The activity of both mitochondrial and cytosolic aconitases was significantly increased in the livers of male rats following treatment with the hypolipidemic drug clofibrate. Cycloheximide or puromycin administration to rats inhibited the inducing effect of clofibrate on the enzyme activity. Aconitase activity in small intestine homogenate was also increased by clofibrate. The drug did not affect the enzyme activity in rat kidney, heart and brain.
D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D009928:Organ Specificity; D011691:Puromycin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology; D013997:Time Factors; D014018:Tissue Distribution
D011691:Puromycin; D003513:Cycloheximide; D000154:Aconitate Hydratase; D002994:Clofibrate