A warfarin-piroxicam drug interaction.
A piroxicam-warfarin interaction is presented with a discussion of the possible mechanism of action. A 60-year-old white male on warfarin therapy for recurrent pulmonary embolism and deep venous thrombophlebitis showed a decrease in his previously therapeutic and stable prothrombin time when piroxicam was discontinued from his drug regimen. On two rechallenges over a ten-month period, his prothrombin times showed consistent and clinically significant fluctuations as piroxicam was added and deleted from his drug regimen.
D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam; D011517:Prothrombin Time; D011655:Pulmonary Embolism / Q000097:blood; D013843:Thiazines / Q000009:adverse effects*; D013924:Thrombophlebitis / Q000097:blood; D014859:Warfarin / Q000009:adverse effects*
D013843:Thiazines; D010894:Piroxicam; D014859:Warfarin