Inclusion compounds of lankacidin-group antibiotics with cyclodextrins.
Lankacidin-group antibiotics formed inclusion compounds with beta-cyclodextrin in molar ratios of about 1:1. These compounds showed remarkably improved water-solubility and stability in aqueous solutions. The structure of the inclusion compounds of lankacidin A is proposed based on the facility of their inclusion with beta-cyclodextrin and the results of 1H NMR spectral studies.
D000900:Anti-Bacterial Agents; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins; D003912:Dextrins; D004339:Drug Compounding; D004355:Drug Stability; D007783:Lactones; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012995:Solubility; D012996:Solutions; D013213:Starch; D014867:Water
D000900:Anti-Bacterial Agents; D003505:Cyclodextrins; D003912:Dextrins; D007783:Lactones; D018942:Macrolides; D012996:Solutions; D014867:Water; C008250:lankacidins; D013213:Starch