Liver DNA synthesis after phenytoin injection in adult NMRI mice.
Stimulation of hepatocyte DNA synthesis was observed in adult mice, as measured by the number of parenchymal cells in S phase, at two different times after a single i.p. injection of diphenylhydantoin (DPH): 18 and 25 hr. No such stimulation was obtained for Kupffer or endothelial cells.
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010672:Phenytoin / Q000494:pharmacology*
D010672:Phenytoin; D004247:DNA