Dosage of tobramycin in cystic fibrosis--a short report.
A 15 kg, 7-year-old girl with cystic fibrosis was admitted with a chest infection. It was found that a tobramycin, 12 mg/kg/day (standard recommended dose 6-7.5 mg/kg/day), was required to obtain acceptable plasma levels and that the volume of distribution varied in line with the patient's weight changes.
D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006207:Half-Life; D006801:Humans; D012141:Respiratory Tract Infections / Q000150:complications / Q000188:drug therapy*; D014031:Tobramycin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D014031:Tobramycin