Antimicrobial activity of some heterocyclic derivatives of 1-methyl-1-nitroethyl sulphides.
The minimum inhibitory concentration values for a group of synthesized heterocyclic derivatives of 1-methyl-1-nitroethyl sulphide were determined for Gram-positive and Gram-negative bacteria, yeast, and fungi. The active compounds were further screened. The effect of these compounds on growth, morphology and incorporation of 3H-uridine was also tested. Comments on the possible model of action of such compounds is included.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004220:Disulfides / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009574:Nitro Compounds / Q000378:metabolism / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004220:Disulfides; D009574:Nitro Compounds