Novel bis(5-arylamino-2-oxo-4-thiazolidinylidene)hydrazine derivatives as potential antineoplastic agents.
A new series of N,N'-bis(5-arylamino-3-benzyl-2-oxo-4-thiazolidinylidene)hydrazine s has been prepared for potential anticancer activity. The synthesis was achieved by reacting 3-benzylthiazolidin-2-one-4-thione with its 4-hydrazone derivative to give N,N'-bis(3-benzyl-2-oxo-4-thiazolidinylidene)hydrazine, which was subjected to dibromination followed by reaction with various primary aromatic amines. Some compounds were evaluated against leukemia P 388 in the mouse. No significant antitumor activity was observed.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006834:Hydrazines / Q000138:chemical synthesis* / Q000627:therapeutic use; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013844:Thiazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D006834:Hydrazines; D013844:Thiazoles