[The role of changes in the antioxidative activity and phospholipid composition of the rat liver in the mechanism of phenazepam action on the liver and the protective effect of talamonal].
Phenazepame exhibited properties of prooxidant in a model system of oleic acid methyl ester oxidation. After single intraperitoneal administration of phenazepame (5 mg/kg) the antioxidative activity (AOA) of rat liver lipids was decreased, correlating with level of histidase and urokinase activity in blood plasma indicating the liver tissue injury. Distinct alterations in the relative content of liver phospholipids were also noted. A phase type of alterations was observed in the content of these phospholipids as well as in the ratio phosphatidyl choline/phosphatidyl ethanolamine; at the same time, the phospholipid ratio was altered simultaneously with the alterations of the enzymatic activities in blood. After administration of the antioxidant, which normalized the AOA level and the phospholipid composition, activities of histidase and urokinase were markedly decreased in blood. The neuroleptanalgetic drug thalamonale, protecting liver tissue against the impairments, normalized the AOA level and the phospholipid composition. Thus, alterations in AOA and in the phospholipid composition reflected distinctly the unfavourable effect of phenazepame as well as the protecting action of thalamonale on liver tissue.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D004329:Droperidol / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005283:Fentanyl / Q000494:pharmacology*; D006638:Histidine Ammonia-Lyase / Q000097:blood; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D004338:Drug Combinations; D008054:Lipid Peroxides; D010743:Phospholipids; D001569:Benzodiazepines; D002084:Butylated Hydroxytoluene; C017928:phenazepam; C001451:Innovar; D014568:Urokinase-Type Plasminogen Activator; D006638:Histidine Ammonia-Lyase; D004329:Droperidol; D005283:Fentanyl
O roli izmeneniĭ antiokislitel'noĭ aktivnosti i sostava fosfolipidov pecheni krys v mekhanizme deĭstviia fenazepama na pechen' i zashchitnom éffekte talamonala.