Loop diuretics may fail to inhibit (Na+, K+, Cl-) 'cotransport' in human red cells.
The inhibition of passive K+ influx into human red blood cells (RBC) by loop diuretics was found to be dependent on the external Na+ concentration. In the absence of external Na+, there was minimal inhibition but the influx remained dependent on Cl- ions. Thus, raising the external Na+ concentration increased the affinity of the putative (Na+, K+, Cl-) cotransport system in human RBC for loop diuretics.
D001693:Biological Transport, Active / Q000187:drug effects; D002034:Bumetanide / Q000494:pharmacology; D002712:Chlorides / Q000097:blood; D004232:Diuretics / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013449:Sulfonamides / Q000494:pharmacology
D002712:Chlorides; D004232:Diuretics; D013449:Sulfonamides; D002034:Bumetanide; D005665:Furosemide; D012964:Sodium; C015451:piretanide; D011188:Potassium