title: Synthesis and quality control of 99mTc-p-butyl IDA.
abstract: A procedure is described for synthesis of p-butyl IDA and for identification of the product by i.r. and NMR spectroscopy and by chemical analysis. A method for preparing this compound by "instant" technique and for its labelling with 99mTc is also given, as well as a procedure for control of the chemical and biological properties of the radiopharmaceutical. Radiochemical study shows a high labelling yield of 95%. Investigation of the biodistribution proves that this preparation is a good hepatobiliary reagent, suitable for use in investigation of the liver functions and for quantitative visualization of the hepatobiliary system.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006525:Hepatitis, Viral, Human / Q000000981:diagnostic imaging*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007098:Imino Acids / Q000138:chemical synthesis* / Q000378:metabolism; D007553:Isotope Labeling; D007700:Kinetics; D015609:Organotechnetium Compounds; D011485:Protein Binding; D011786:Quality Control; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000138:chemical synthesis* / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; C024340:technetium Tc 99m (para-butyl)iminodiacetic acid; D013667:Technetium