[Action of unithiol on the toxic effect of antitumor preparations].
The effect of unitiol treatment on the toxicity of dactinomycin, 5-fluorouracil, bleomycetin and vincristine was studied in CBA mice. Unitiol treatment was shown to decrease the acute toxicity of dactinomycin and involves a lower loss of body weight. Also, it reduced dactinomycin hemotoxicity which was assessed on the basis of leukocyte count in peripheral blood. Conversely, unitiol potentiated the acute toxic effect of 5-fluorouracil, bleomycetin and vincristine which was matched by body weight loss following treatment with cytostatic drugs. The results point to a wide range of the biological effects of unitiol.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004347:Drug Interactions; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014494:Unithiol / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004112:Dimercaprol; D014494:Unithiol
Deĭstvie unitiola na toksicheskiĭ éffekt nekotorykh protivoopukholevykh preparatov.