A comparison of the effects of the optical isomers of isoproterenol on energy metabolism in a mouse sarcoma.
Disturbance to energy production in the S180 sarcoma (CB) by optical isomers of isoproterenol was assessed from altered adenine nucleotide levels at 1 h. The L-isomer almost halved the ATP level and lowered the energy charge significantly; the D-isomer was inactive. Dependence of tumor injury on cytochrome P-450 activity appears unlikely.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D005609:Free Radicals; D007213:Indomethacin / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D010100:Oxygen / Q000378:metabolism; D012039:Regional Blood Flow / Q000187:drug effects; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000378:metabolism*; D013237:Stereoisomerism
D000227:Adenine Nucleotides; D005609:Free Radicals; D007545:Isoproterenol; D010100:Oxygen; D007213:Indomethacin