Thrombotic thrombocytopenic purpura in pregnancy: response to plasma manipulations.
We present three cases of thrombotic thrombocytopenic purpura (TTP) and one case of the hemolytic-uremic syndrome (HUS) occurring during pregnancy. All patients and their offspring survived, and none of the infants had TTP or HUS. Plasma manipulations (exchange and infusions) were the effective therapeutic measures in all patients. The most significant complication of therapy was posttransfusion hepatitis, which occurred in three patients, and from which recovery was complete.
D000328:Adult; D001803:Blood Transfusion; D017707:Erythrocyte Transfusion; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010951:Plasma Exchange; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000628:therapy*; D065227:Transfusion Reaction