Nutrition and immunity: the immunoregulatory effect of n-6 essential fatty acids is mediated through prostaglandin E.
Suppression of cell-mediated immune responses by essential fatty acids (EFA) was demonstrated in mice maintained on a standard laboratory diet for rodents. Daily oral administration of EFA at doses ranging from 125 to 750 mg/kg body weight significantly suppressed local host-versus-graft and graft-versus-host reactions as measured by popliteal lymph node assay. Studies employing immune sera directed against E-type prostaglandin demonstrated that n-6 EFA-induced suppression was mediated through prostaglandin E1. In titration experiments the effect of n-6 EFA on the reactions was dose dependent with enhancement of the responses at low concentrations and suppression at high concentrations.
D000527:Alprostadil; D000818:Animals; D000906:Antibodies / Q000276:immunology; D005228:Fatty Acids, Essential / Q000276:immunology* / Q000494:pharmacology; D006087:Graft vs Host Reaction / Q000187:drug effects; D006789:Host vs Graft Reaction / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009747:Nutritional Physiological Phenomena; D011458:Prostaglandins E / Q000276:immunology*; D013154:Spleen / Q000637:transplantation; D014184:Transplantation, Homologous
D000906:Antibodies; D005228:Fatty Acids, Essential; D011458:Prostaglandins E; D000527:Alprostadil