Pharmacological actions of diaspirins, potential antisickling agents: analgesic and anti-inflammatory effects.
Three aspirin analogs, dibromoaspirin, bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate, potential antisickling agents, were compared with acetylsalicylic acid (aspirin) for their analgesic, body temperature and anti-inflammatory effects in the laboratory mouse and rat. In the analgesic assay, using the "writhing method", only a 200 mg/kg dose of the diaspirin succinate significantly reduced the writhing response induced by phenylacetic acid. Only a dose of 800 mg/kg of acetylsalicylic acid significantly decreased writhing. These analog compounds had only slight hypothermic effects, the reduction in body temperature not being appreciable. On the other hand, they were effective anti-inflammatory agents, comparable to aspirin; a dose of 200 mg/kg very significantly reduced the paw edema due to injected carrageenan.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000986:Antisickling Agents / Q000494:pharmacology*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000986:Antisickling Agents; C021630:bis(3,5-dibromosalicyl)fumarate; C021631:bis(3,5-dibromosalicyl)succinate; D001241:Aspirin