[Effect of the antioxidant dibunol and its combination with phenazepam on the behavior of rats in a conflict situation].
The influence of dibunol, phenazepam used alone and combined on rat conflict behavior and rat blood and brain malonic dialdehyde content was studied. It was shown that dibunol exerts an unmarked anticonflict action that can be removed by bicuculline. Combined administration of dibunol and phenazepam potentiates appreciably the anticonflict effect. This permits reducing the doses of the drugs. The anxiolytic effect of dibunol alone and combined with phenazepam is attended by a decrease in the content of malonic dialdehyde in rat blood and brain, evidence of the reduction of the lipid peroxidation intensity.
D000818:Animals; D014151:Anti-Anxiety Agents; D000975:Antioxidants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D014151:Anti-Anxiety Agents; D000975:Antioxidants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D002084:Butylated Hydroxytoluene; C017928:phenazepam; D008315:Malondialdehyde; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline
Vliianie antioksidanta dibunola i ego kombinatsii s fenazepamom na povedenie krys v usloviiakh konfliktnoĭ situatsii.