Effects of gonadotrophin-induced elevation of serum testosterone upon somatomedin C levels and serum thymidine activity in children.
3H-thymidine uptake into lectin-activated human lymphocytes allows to measure a growth-stimulating activity of serum, the thymidine activity (TA), which is GH dependent in vivo and related to somatomedins (Sm). In this work, it is shown: that addition of human chorionic gonadotrophin (HCG) or testosterone in vitro does not increase the 3H-thymidine uptake into lymphocytes; that the gonadotrophin-induced elevation of testosterone in children is accompanied by a significant increase of TA and, at a lesser degree, of Sm C; that these two increases are significantly correlated, and that the age-related variation of TA and Sm C after HCG stimulation test are not parallel.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D013002:Somatomedins / Q000097:blood*; D013739:Testosterone / Q000097:blood*; D013936:Thymidine / Q000097:blood*
D006063:Chorionic Gonadotropin; D037102:Lectins; D013002:Somatomedins; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D013936:Thymidine