[Animal experiment studies on the hemodynamic effect of adrenaline following intravenous and endobronchial administration].
The objective of this study was to find a dosage of endobronchially administered epinephrine with haemodynamic effects comparable to those after intravenous injection and therefore useful in cardiopulmonary resuscitation without an intravenous line. We found that 100 micrograms/kg epinephrine given endobronchially was almost as effective as an intravenous dose of 10 micrograms/kg concerning onset (10 seconds after intravenous injection, 15 seconds after endobronchial instillation) and maximum drug effect but with a remarkable prolongation of drug action. The instillation of 250 micrograms/kg epinephrine produced no significant increase in haemodynamic response. It was concluded, that the endobronchial instillation of epinephrine--in adequate dosage--is very useful in CPR without an intravenous line.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male
D004837:Epinephrine
Tierexperimentelle Untersuchungen zur hämodynamischen Wirkung von Adrenalin nach intravenöser und endobronchialer Applikation.