Effects of phencyclidine administration on behavior and brain neurotensin-like immunoreactivity in rats.
The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in the frontal cortex (Fc) alone. These results suggest that the decrease in NTLI in Fc is related to the behavioral abnormalities produced by PCP.
D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D005625:Frontal Lobe / Q000032:analysis; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009496:Neurotensin / Q000032:analysis*; D010622:Phencyclidine / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D009496:Neurotensin; D010622:Phencyclidine