Graphical approach for determining whether absorption and elimination rate constants are equal in the one-compartment open model with first-order processes.
An equation was developed which enables blood level data to be utilized for determining whether or not the first-order absorption and elimination rate constants are equal in the one-compartment open model. This equation was tested using simulated data with excellent results.
D000042:Absorption; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*
D004364:Pharmaceutical Preparations