title: [Prevention of impairment of myocardium metabolism and function in immobilization stress using previous adaptation to short stress exposures].
abstract: A long-term immobilization stress was shown to cause a distinct enzymemia in rats. Simultaneously, activation of lipid peroxidation and a decrease in glycogen content were observed in myocardium; a distinctly increased penetration of aspartate transferase, lactate- and malate dehydrogenases and RNAase into coronary circulation was found in isolated heart of the animals. These impairments of metabolism were accompanied by a depression of the heart contractile function. The impairments in metabolism and in heart functions might be prevented by preadaptation of the animals to multiple short-term immobilization effects, which did not cause any impairments per se.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D003402:Creatine Kinase / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D007103:Immobilization; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000097:blood; D008297:Male; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D013997:Time Factors
chemical_list: D008054:Lipid Peroxides; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D003402:Creatine Kinase
vernacular_title: Preduprezhdenie narusheniĭ metabolizma i funktsii serdechnoĭ myshtsypri immobilizatsionnom stresse s pomoshch'iu predvaritel'noĭ adaptatsii k korotkim stressornym vozdeĭstviiam.