title: [Activity of polymorphic N-acetyltransferase in epilepsy].
abstract: Activity of polymorphic N-acetyl transferase characterized by bimodality (fast and slow acetylators) in normal subjects was studied in 150 epileptic patients. The epileptic versus normal subjects had a significant predominance of slow acetylators. The data obtained suggest that slow acetylation is one of the possible factors predisposing to epilepsy and responsible for a more severe course of the disease. The results of the study suggest that determination of the activity of polymorphic N-acetyl transferase may serve as a prognostic criterion of epilepsy.
mesh_terms: D000123:Acetyltransferases / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D004827:Epilepsy / Q000201:enzymology* / Q000235:genetics; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009031:Moscow; D011110:Polymorphism, Genetic; D011379:Prognosis
chemical_list: D007527:Isoenzymes; D000123:Acetyltransferases
vernacular_title: Aktivnost' polimorfnoĭ N-atsetiltransferazy pri épilepsii.