Detection of circulating T-activating enzyme in the serum of a patient having hemolytic-uremic syndrome and disseminated intravascular coagulation.
A three-and-a-half-year old boy suffering from streptococcal pneumonia developed hemolytic-uremic syndrome and disseminated intravascular coagulation (DIC). His red blood cells (RBC) were shown to be T- and Tk-activated; serial testing showed his mature RBCs as well as neocytes remained T-activated at 40 days. Anti-T was detected in his serum, with only one of two T-activated RBC samples. T-activating enzyme was shown to be present in his serum.
D015295:Antigens, Tumor-Associated, Carbohydrate; D001789:Blood Group Antigens / Q000276:immunology; D002675:Child, Preschool; D004187:Disaccharides / Q000032:analysis* / Q000276:immunology; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000201:enzymology*; D004903:Erythrocyte Aggregation / Q000187:drug effects; D006386:Hemagglutination Tests; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000201:enzymology*; D006583:Hexadimethrine Bromide; D006801:Humans; D037102:Lectins; D008297:Male
D015295:Antigens, Tumor-Associated, Carbohydrate; D001789:Blood Group Antigens; D004187:Disaccharides; D037102:Lectins; C016467:Thomsen-Friedenreich antigen; D006583:Hexadimethrine Bromide