[Characteristics of serotonin binding by the cells of immunocompetent tissues and synaptosomes].
The ratio of surface and intracellular serotonin binding by the cells of immunocompetent tissues and synaptosomes of immunized and intact CBA mice was studied by treatment with imipramine inhibiting serotonin penetration through the cytoplasmic membrane. As early as 5 minutes after the antigen injection the content of intracellular amine increased with changes in its binding by the cytoplasmic membrane. The probability of the functional interconnection between the reaction of immunocompetent tissues to the antigen and two forms of serotonin binding by the cells of these tissues is discussed.
D000042:Absorption; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004351:Drug Resistance; D007099:Imipramine / Q000494:pharmacology; D007114:Immunization; D007121:Immunocompetence / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D013499:Surface Properties; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D011985:Receptors, Serotonin; D012701:Serotonin; D007099:Imipramine
Nekotorye kharakteristiki sviazyvaniia serotonina kletkami immunokompetentnykh tkaneĭ i sinaptosomami.