Functional impairment of mitochondria from rat livers acutely injured by thioacetamide.
Thioacetamide, when administered in a dose of 100 mg/kg body weight to adult female rats, leads to functional disturbances in mitochondria isolated from livers 24 h after its application. The RCI is significantly reduced due to an increase in state 4 respiration and a lowered state 3 activity. Maximum respiratory activity of the mitochondria is also depressed. The mitochondrial Ca2+-content is significantly increased to 185%. In accordance with the uncoupling effect the Ca2+-transport behaviour of the hepatic mitochondria from thioacetamide-injured rats is altered. The results are indicative of structural alterations of the inner mitochondrial membranes.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D005260:Female; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013853:Thioacetamide / Q000494:pharmacology*
D000081:Acetamides; D003580:Cytochromes; D013853:Thioacetamide; D002118:Calcium