title: Myotrophic effects on denervation atrophy of hindlimb muscles of mice with systemic administration of nerve extract.
abstract: Atrophy was assessed in denervated hindlimb muscles of adult mice which either were not otherwise treated or received daily intraperitoneal injections of extract of rats' sciatic nerves. After 7 days, the denervated muscles of injected animals exhibited significantly smaller decreases in wet weight, total protein and cross-sectional areas of muscle fibers relative to innervated contralateral control muscles. The effects of denervation and nerve extract on different muscles varied.
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009121:Muscle Denervation / Q000009:adverse effects; D009133:Muscular Atrophy / Q000209:etiology / Q000517:prevention & control*; D009928:Organ Specificity; D010525:Peripheral Nerves; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D014020:Tissue Extracts