Decomposition of aspirin in the solid state in the presence of limited amounts of moisture.
When limited amounts of moisture are added to aspirin in a closed system, the model for decomposition differs from that experienced in an open system, i.e., a system at constant relative humidity. The composition of the liquid decomposition layer on the surface of the aspirin crystals will constantly change, and a model for accounting for both the change in volume and composition of the decomposition layer as a function of time has been developed. Solid-state decomposition data, when plotted as a function of time, exhibit a profile similar to the one predicted, but the position of the decomposition curve observed differs from that of the predicted. The predicted curve indicates better stability than the observed data.
D000085:Acetates; D001241:Aspirin; D004355:Drug Stability; D006813:Humidity; D007700:Kinetics; D012459:Salicylates; D020156:Salicylic Acid; D012995:Solubility; D013696:Temperature; D013997:Time Factors; D014867:Water
D000085:Acetates; D012459:Salicylates; D014867:Water; D020156:Salicylic Acid; D001241:Aspirin