Effect of toxic doses of progesterone on hepatotoxic effects of tetracycline.
The combined effects of high doses of tetracycline and progesterone on parameters indicative for liver function (serum transaminases and urea, serum and liver triglycerides and cholesterol) have been studied in mice. Apart from disturbance of cholesterol metabolism tetracycline-induced liver dysfunction was not aggravated by progesterone.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D051379:Mice; D011374:Progesterone / Q000633:toxicity*; D013752:Tetracycline / Q000633:toxicity*; D014280:Triglycerides / Q000378:metabolism; D014508:Urea / Q000097:blood
D002788:Cholesterol Esters; D014280:Triglycerides; D011374:Progesterone; D014508:Urea; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D013752:Tetracycline