Diurnal variations in electroconvulsive shock-induced seizures: involvement of endogenous opioids.
Electroconvulsive shock (ECS)-induced seizures present a clear cut diurnal rhythmicity when BALB/c mice are subjected to a light-dark (L/D) schedule. On the contrary, in the absence of external synchronizers no evident fluctuations in epileptic behaviour were evident. Naloxone decreased the threshold of ECS-induced convulsions, thus confirming an involvement of opioids in this type of behaviour. These findings indicate that opioids present a diurnal (L/D) but not circadian (L/L) rhythmicity in BALB/c mice.
D000222:Adaptation, Physiological; D000818:Animals; D001921:Brain / Q000503:physiopathology*; D002940:Circadian Rhythm; D004597:Electroshock; D004723:Endorphins / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone; D012640:Seizures / Q000209:etiology / Q000503:physiopathology*
D004723:Endorphins; D009270:Naloxone