Four-year follow-up of insertion of quinacrine hydrochloride pellets as a means of nonsurgical female sterilization.
Eighty-four women were admitted to a study in Baroda, India, designed for evaluation of the efficacy of three transcervical insertions of quinacrine hydrochloride pellets, each 1 month apart, in producing occlusion of the oviducts. A 4-year follow-up has been completed for 100% of the women. Three women became pregnant during the time between the first and third administrations. Of the 81 women remaining in the study after administrations were complete, 3 became pregnant during the 4-year follow-up period, which resulted in a cumulative life-table pregnancy rate of 3.7 at 48 months. The results of this study indicate that intrauterine insertion of quinacrine pellets can be a safe, effective nonsurgical sterilization procedure.
D000328:Adult; D000818:Animals; D002584:Cervix Uteri; D005187:Fallopian Tubes / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008253:Macaca mulatta; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013245:Sterilization, Reproductive / Q000009:adverse effects
D011796:Quinacrine