Brain NADH and jumping behavior in the rat.
The effects of either the reduced Nicotinamide Adenine Dinucleotide (NADH) microinjected into the brain or amphetamine injected peritoneally on jumping behavior were observed in 68 rats. The enhanced jumps in the group with amphetamine are the greatest among the three experimental groups. The enhanced effect of NADH microinjected into the caudate nucleus is stronger than those of NADH in the frontal cortex. The effects of extra NADH in the frontal cortex on the jumps are dose-dependent. NADH concentrations in the brain of rats with amphetamine increased immediately after behavioral procedure. The increased concentrations in the brain from both extra and intra sources are related to the enhanced jumps of rats.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D009243:NAD / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D009243:NAD; D000661:Amphetamine