Effect of glucocorticoid treatment on skin capillary blood flow and viability in cutaneous and myocutaneous flaps in the pig.
The effect of methylprednisolone treatment on skin-flap viability and capillary blood flow was studied in a series of four experiments. Intramuscular methylprednisolone injections (30 mg/kg per day), given in single or divided doses preoperatively or postoperatively, had no effect in augmenting skin viability in arterialized cutaneous, myocutaneous, or random skin flaps compared with the control. Capillary blood flow was studied in arterial buttock flaps and latissimus dorsi myocutaneous flaps raised on animals treated preoperatively with methylprednisolone or saline (control), and no significant difference in capillary blood flow was noted between the treatment and control flaps. It was concluded that methylprednisolone has no significant therapeutic effect either in increasing flap viability or in increasing capillary blood flow in skin flaps in pigs.
D000818:Animals; D002196:Capillaries; D004305:Dose-Response Relationship, Drug; D005451:Fluorescein Angiography; D006085:Graft Survival / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology*; D009132:Muscles / Q000098:blood supply*; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps; D013552:Swine; D013997:Time Factors
D008775:Methylprednisolone