title: Tetrodotoxin derivatives in puffer fish.
abstract: Analysis of puffer fish tissue extracts by a fluorometric tetrodotoxin analyzer revealed the presence of three tetrodotoxin derivatives besides tetrodotoxin. The derivatives were isolated and identified as tetrodonic acid, 4-epitetrodotoxin and anhydrotetrodotoxin on the basis of mass spectral and 1H NMR measurements. The lethal potencies of 4-epitetrodotoxin and anhydrotetrodotoxin to mice by i.p. injection were 710 and 92 mouse units/mg, respectively.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005400:Fishes, Poisonous / Q000378:metabolism*; D007422:Intestines / Q000032:analysis; D008099:Liver / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012867:Skin / Q000032:analysis; D013050:Spectrometry, Fluorescence; D013779:Tetrodotoxin / Q000032:analysis* / Q000633:toxicity
chemical_list: D013779:Tetrodotoxin