Metoprolol for intermittent explosive disorder.
Metoprolol, a selective beta 1-adrenoreceptor blocker, was administered to two patients with intermittent explosive disorder who had not done well with previous medications, including propranolol and carbamazepine. Both patients improved dramatically, suggesting clinical and theoretical relevance.
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D000786:Anger / Q000187:drug effects*; D002220:Carbamazepine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D019965:Neurocognitive Disorders / Q000523:psychology; D011433:Propranolol / Q000627:therapeutic use; D011889:Rage / Q000187:drug effects*; D014754:Violence
D002220:Carbamazepine; D011433:Propranolol; D008790:Metoprolol