Sympathetic ganglia augment growth of neuroblastoma in vitro.
The sympathetic nervous system modulates the growth of C-1300 mouse neuroblastoma (C-1300 NB) in vivo. We now report that the presence of sympathetic cervical ganglia in cultures containing C-1300 NB or dispersed S-20 neuroblastoma (S-20 NB) cells augments growth of these tumors in vitro. Sympathetic ganglia-conditioned medium increases proliferation and survival of S-20 NB cells, indicating that nervous system-derived growth factors can exert an effect on neoplastic cells.
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D003470:Culture Media; D005728:Ganglia, Sympathetic / Q000502:physiology*; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology; D009447:Neuroblastoma / Q000473:pathology*
D003470:Culture Media; D009414:Nerve Growth Factors