Neonatal monosodium glutamate administration alters noradrenergic measures in the brainstem of the mouse.
Mice treated neonatally with MSG (4 mg/g) were compared to saline-injected controls on a number of neurochemical parameters of brainstem noradrenergic activity. MSG treatment resulted in an attenuation of brainstem norepinephrine (NE) decline after alpha-methyl-p-tyrosine administration. Neonatal MSG administration did not result in alterations in the steady state levels of brainstem NE or MOPEG. The synthesis of NE was slightly increased in the pons-medulla of MSG-treated mice as indexed by pargyline-induced NE accumulation. NE release, however, appeared diminished as reflected by a significant (p less than 0.05) decrease in the ratio of normetanephrine to NE found in the pons-medulla of MSG-treated mice given pargyline. The results suggest that MSG-induced damage to the arcuate nucleus produces selective alterations in brainstem NE systems. These alterations may reflect the toxic action of MSG on the opiomelanocortin neurons of the arcuate nucleus or other descending systems that are damaged by MSG. The loss of the descending opiomelanocortin input to the brainstem could result in these types of neurochemical consequences since the pharmacologic action of opiate drugs results in a selective enhancement of brainstem NE turnover in rodents.
D000818:Animals; D000831:Animals, Newborn; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects* / Q000502:physiology; D001933:Brain Stem / Q000032:analysis* / Q000502:physiology; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis; D051379:Mice; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000032:analysis*; D009647:Normetanephrine / Q000032:analysis; D011333:Pro-Opiomelanocortin / Q000502:physiology; D012970:Sodium Glutamate / Q000494:pharmacology*
D005971:Glutamates; D009647:Normetanephrine; D008734:Methoxyhydroxyphenylglycol; D011333:Pro-Opiomelanocortin; D012970:Sodium Glutamate; D009638:Norepinephrine