Precipitated opiate abstinence in utero.
Following direct infusion of morphine (0.6 to 80.0 mg/hr) to the fetal lamb for 2 to 6 hours, naloxone administration precipitated a fetal abstinence syndrome consisting of desynchronization of electrocortical activity; increased total body movements, neck tone, and eye movements; continuous rapid, deep breathing movements; immediate bradycardia associated with transient increases in systolic, diastolic, and pulse pressures; and meconium staining of the amniotic fluid. This syndrome resembles that observed in the opiate-abstinent human neonate.
D000818:Animals; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D005323:Fetal Monitoring; D005324:Fetal Movement / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009020:Morphine / Q000009:adverse effects; D009270:Naloxone / Q000494:pharmacology; D009294:Narcotics / Q000009:adverse effects*; D011247:Pregnancy; D012756:Sheep; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D009294:Narcotics; D009270:Naloxone; D009020:Morphine