title: Empyema: analysis of treatment techniques.
abstract: Empyema is associated with a high mortality. To study the factors responsible for the failure of treatment, the authors reviewed 90 cases of nontuberculous thoracic empyema seen at the University of Western Ontario in London, between 1970 and 1980. The most common causes of empyema were bronchopulmonary infections (63%), complications of pulmonary surgery (14%) and secondary infections of hydrothoraces or hemothoraces (13%). In 51 patients (57%) the condition was acquired in hospital or was related to previous medical therapy. Nine cases were recognized only at autopsy. The treatment of empyema was assessed in 81 patients, who received an average of 2.2 antibiotics during the course of treatment. Five patients received antibiotics as the only therapy; one died. Seventy-two patients were treated by surgical drainage; 35 (49%) were cured and 18 (25%) subsequently died. Twelve of 18 decortication procedures were successful including 4 performed as a primary procedure and 8 as a secondary procedure. Five of seven patients who underwent thoracoplasty were cured. The overall mortality in the series was 23%. Prevention and early recognition of empyema may reduce the mortality. Patients who do not improve promptly with surgical drainage may benefit from early decortication.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology / Q000628:therapy; D001982:Bronchial Diseases / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection; D004322:Drainage; D004653:Empyema / Q000209:etiology / Q000401:mortality* / Q000628:therapy; D005260:Female; D006491:Hemothorax / Q000150:complications / Q000209:etiology; D006801:Humans; D007223:Infant; D008168:Lung / Q000601:surgery; D008171:Lung Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D013903:Thoracic Surgery; D013905:Thoracoplasty
chemical_list: D000900:Anti-Bacterial Agents