Pararenal angiosarcoma induced in male mice by 1,2-dimethylhydrazine--a model for studying the role of androgens in chemical carcinogenesis.
CBA male mice treated with 1,2-dimethylhydrazine (DMH) developed high incidence (up to 97%) of pararenal angiosarcomas. Castration that preceded DMH-treatment almost completely inhibited the induction of these tumours while castration that followed DMH-treatment had on influence on their development. Testosterone propionate (TP) was efficient in restoring the incidence of DMH-induced pararenal tumours in castrated males only when given simultaneously with DMH and was totally inefficient when given after the cessation of DMH-administration. Castrated CBA female mice developed 92% of pararenal angiosarcomas when they received combined treatment with DMH and TP; no such tumours appeared in the intact females treated with DMH alone. The incidence of pararenal tumours in males of different strains was as follows: CBA, 97%; (CBA X C57Bl)F1, 36%; C57Bl, 4%; C3H, 35%; BALB/c, 13%; C3HA, 7%.
D019813:1,2-Dimethylhydrazine; D000236:Adenoma / Q000139:chemically induced; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002273:Carcinogens; D002369:Castration; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D013045:Species Specificity; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D013739:Testosterone; D019813:1,2-Dimethylhydrazine