title: Premedication of dogs with acepromazine or pentazocine before euthanasia with carbon monoxide.
abstract: Euthanasia of unwanted or sick animals should always be done in a humane manner. This study involving two groups of 12 dogs evaluated a two step method of euthanasia using first acepromazine or pentazocine then inhalation of carbon monoxide. During the experiment, behavioral reactions (anxiety, agitation, vocalization and sphincter relaxation) and physiological parameters (electro-encephalogram, electrocardiogram, arterial blood pressure, respiratory and heart rates and serum cortisol) were monitored. The results showed that both drugs modified many behavioral reactions and physiological changes associated with administration of carbon monoxide. Acepromazine and pentazocine reduced by 25% and 20% respectively the number of dogs that showed vocalization and agitation. In acepromazine premedicated dogs, the duration of these signs was significantly diminished and sphincter relaxation did not occur in more than 50% of cases. Furthermore, with the use of acepromazine, no significant peaks or drastic drops were noticed in the heart and respiratory rates and in the arterial blood pressure. These manifestations are usually related to stress. In light of these results, it is recommended to premedicate dogs with acepromazine before submitting them to euthanasia by carbon monoxide inhalation.
mesh_terms: D000075:Acepromazine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002248:Carbon Monoxide; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D004569:Electroencephalography / Q000662:veterinary; D005065:Euthanasia / Q000662:veterinary*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010423:Pentazocine / Q000494:pharmacology*; D011292:Premedication / Q000662:veterinary*; D012119:Respiration / Q000187:drug effects
chemical_list: D000075:Acepromazine; D002248:Carbon Monoxide; D010423:Pentazocine; D006854:Hydrocortisone