Gastrointestinal effects of the extracts of Rhigiocarya racemifera (Menispermaceae).
The gastrointestinal effects of the aqueous extract of Rhigiocarya racemifera was studied in rats and was compared with that of cimetidine. Ulcers were induced in rats by means of drugs: indomethacin, reserpine and serotonin and by shay rats. The extract was found to have significant (P less than 0.05) antiulcer activity against all the models studied. The LD50 was found to be 141.25 mg/kg body weight and ED50 16.5 mg/kg. Phytochemical studies revealed the presence of glycosides, saponins, and tanins. The extract does not show antimicrobial effects.
D000818:Animals; D002927:Cimetidine / Q000627:therapeutic use; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006027:Glycosides / Q000032:analysis; D007213:Indomethacin; D008026:Ligation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009549:Nigeria; D010936:Plant Extracts / Q000032:analysis / Q000627:therapeutic use* / Q000633:toxicity; D010946:Plants, Medicinal; D011708:Pylorus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine; D012503:Saponins / Q000032:analysis; D012701:Serotonin; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology; D013634:Tannins / Q000032:analysis
D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D013634:Tannins; D012701:Serotonin; D002927:Cimetidine; D012110:Reserpine; D007213:Indomethacin