Sodium-independent binding of [3H]cocaine in mouse striatum is serotonin related.
There was a highly significant correlation between IC50 values of various drugs in inhibiting the Na+-independent [3H]cocaine binding in the mouse striatum and their values in inhibiting the synaptosomal uptake of [3H]serotonin. In contrast, there was no correlation between the inhibition of binding in the absence of Na+ and the inhibition of [3H]dopamine uptake. Lesioning of serotonergic nerve terminals with 5,7-dihydroxytryptamine reduced the Na+-independent [3H]cocaine binding, without affecting the Na+-dependent binding. These results indicate that the bulk of the Na+-independent [3H]cocaine binding in the mouse striatum is associated with serotonergic nerve terminals.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D003042:Cocaine / Q000378:metabolism*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012701:Serotonin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D012964:Sodium; D003042:Cocaine; D004298:Dopamine