title: The antagonism of acetylcholine excitatory and inhibitory responses of Helix central neurones, by some neuromuscular blocking drugs.
abstract: Intracellular recordings were made from identified central neurones of the snail Helix aspersa. The antagonism of acetylcholine excitatory and inhibitory responses by d-tubocurarine, HS818 and HS626 was investigated. d-Tubocurarine was equipotent against both the inhibitory and excitatory responses, while HS626 and HS818 were of similar potency to d-tubocurarine in antagonising acetylcholine excitation but were approximately one order of magnitude less potent in antagonising the inhibitory response.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000736:Androstenes / Q000494:pharmacology*; D000818:Animals; D006372:Helix, Snails; D066298:In Vitro Techniques; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D000736:Androstenes; D009466:Neuromuscular Blocking Agents; C006958:chandonium iodide; C046383:HS 626; D000109:Acetylcholine; D014403:Tubocurarine