title: Inversion (14)(q12qter) or (q11.2q32.3): the most frequently acquired rearrangement in lymphocytes.
abstract: In a large study of chromosome rearrangements occurring in human lymphocytes from normal subjects, inv (14)(q12qter) or (q11.2q32.3) is found to be the most frequent, affecting 0.15% of mitoses. The same inversion is observed in the lymphocytes of the chimpanzee, indicating the ancestry of this inversion. It is not induced by ionizing radiations, and its frequency may be increased in Fanconi anemia, but not in ataxia telangiectasia. It may represent one of the steps of the process of leukemogenesis.
mesh_terms: D000818:Animals; D001260:Ataxia Telangiectasia / Q000235:genetics; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002901:Chromosomes, Human, 13-15; D005199:Fanconi Anemia / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D002679:Pan troglodytes; D013045:Species Specificity