Non-neoplastic lesions of female virgin Han:NMRI mice, incidence and influence of food restriction throughout life span. II: Respiratory tract.
A life-span study with 900 female virgin Han:NMRI mice (300 outbred controls, 300 of a fat subline and 300 of a lean subline) was carried out to determine the occurrence of spontaneous diseases with ad libitum or restricted feeding. Rare non-neoplastic lesions of the lungs (1-8%) were secondary inflammations, focal ossification and subintimal arterial 'plaques'. More frequent were age-dependent pulmonary mineralizations similar to psammoma bodies (3-18%) and crystal formations (4-22%). Food restriction did not affect the incidence of these lesions directly. Crystals were observed furthermore within infoldings of the tracheobronchial mucosa and intra- as well as extracellularly in the nasal cavities.
D000821:Animal Feed; D000818:Animals; D003461:Crystallography; D005260:Female; D008168:Lung / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009297:Nasal Mucosa / Q000473:pathology; D009765:Obesity; D012140:Respiratory Tract Diseases / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000453:epidemiology* / Q000473:pathology; D013045:Species Specificity; D013851:Thinness; D014132:Trachea / Q000473:pathology