Mania in two sisters with similar cerebellar disturbance.
The authors describe two sisters who presented with a clinical picture consistent with mania. On further investigation, both had marked vermian and cerebellar cortical atrophy on CAT scans. Their mother also had a history suggestive of cerebellar disease. To the authors' knowledge, this is the first report of familial cerebellar disease with a clinical presentation of mania.
D000328:Adult; D001284:Atrophy; D001714:Bipolar Disorder / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D002526:Cerebellar Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D002531:Cerebellum / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D014057:Tomography, X-Ray Computed