Calcium-induced lens protein aggregation accelerated by reactive oxygen species photosensitized in the presence of hydroxykynurenines.
Photo-oxidation with 3-OH L-kynurenine O-beta-glucoside or 3-OH L-kynurenine accelerates the aggregation of water-soluble protein in the rat lens due to the presence of calcium ion. The present report demonstrates that hydrogen peroxide and superoxide anion mediate a large part of the photodynamic acceleration with hydroxykynurenine compounds. In addition, 3-OH L-kynurenine O-beta-glucoside seems to photosensitize more of the two reactive oxygen species than 3-OH L-kynurenine. The findings are discussed together with other photodynamic effects of hydroxykynurenine compounds.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002374:Catalase / Q000494:pharmacology; D003459:Crystallins / Q000378:metabolism*; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008027:Light; D010084:Oxidation-Reduction; D011489:Protein Denaturation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013482:Superoxide Dismutase / Q000494:pharmacology
D003459:Crystallins; D005960:Glucosides; D006027:Glycosides; C029366:hydroxykynurenine glucoside; C005045:3-hydroxykynurenine; D007737:Kynurenine; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D002118:Calcium