[Ultrastructural mechanisms of the antacid effect of biomet in duodenal ulcer patients].
Corpus gastric mucosa, obtained via repeated blind aspiration biopsy--before and after 10 day treatment with biomet--1 g daily, was electron microscopically studied in 10 patients with active duodenal ulcer. Before the treatment, the wall-adjoining cells were with high hyperplasia of intracytoplasmatic tubules, which pressed in separate groups-packets the numerous mitochondria with data about hyper-reactivity, on the background of scarce or absent tubulo-vesicular structures. After a 10-day biomet treatment, the reduced area of intracytoplasmatic tubules of wall-adjoining cells is obvious as well as the recovery of tubulo vesicular structures. Often, in single patients, endocrine G cells were observed. With the intragastric pH-metry, however, performed in 2 of the patients, before and by 90 min after the intravenous administration of 200 mg tagamet--significantly elevated values of pH of gastric mucosa were established, positively correlating with the described ultrastructural changes in wall-adjoining cells. The antacid effect of biomet, is very likely, realized via the mechanism of reduction of the surface of the secreting membrane structures, responsible for the production of hydrochloric acid by gastric mucosa.
D001707:Biopsy, Needle; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008854:Microscopy, Electron; D010295:Parietal Cells, Gastric / Q000187:drug effects / Q000648:ultrastructure; D013997:Time Factors
D002927:Cimetidine
Ultrastrukturni mekhanizmi na antiatsidniia efekt na biomet pri bolni s duodenalna iazva.