Antinociceptive effect of intracisternal carbamazepine evidenced by the bradykinin-induced biting-like response in rats.
Intracisternal injections of carbamazepine produced a rapid and dose-dependent suppressive effect on the biting-like response induced by microapplication of bradykinin onto the tooth pulp (ED50: 2.62 micrograms/rat). Thus, the medullary dorsal horn is probably one of the primary sites for the antinociceptive activity of carbamazepine.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology; D002220:Carbamazepine / Q000494:pharmacology*; D008297:Male; D009055:Mouth; D009619:Nociceptors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014070:Tooth
D002220:Carbamazepine; D001920:Bradykinin