The effect of 1 alpha-hydroxyvitamin D3 on primary antibody formation in mice.
The immunoregulatory effect of 1 alpha-hydroxyvitamin D3, a precursor form of active vitamin D3 (1,25-dihydroxyvitamin D3), was examined in three different kinds of experimental systems in mice. Oral administration of 0.05 and 0.2 micrograms/kg of 1 alpha-hydroxyvitamin D3 augmented the primary immune response induced by immunization with 1 X 10(7) sheep erythrocytes, although it did not influence a maximal level of antibody formation induced by immunization with 5 X 10(8) sheep erythrocytes. The same treatment also restored the immune response depressed by restraint-stress. Furthermore, 1 alpha-hydroxyvitamin D3 suppressed the anti-dinitrophenyl plaque-forming cell response enhanced by colchicine injection to near the normal level. These results suggest that 1 alpha-hydroxyvitamin D3 enhanced or suppressed the immune response through activating helper and suppressor cells in dependence on the magnitude of the response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003078:Colchicine / Q000037:antagonists & inhibitors; D004140:Dinitrophenols / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology
D004140:Dinitrophenols; D006887:Hydroxycholecalciferols; D003078:Colchicine; C008088:alfacalcidol