Fresh frozen plasma in the treatment of chronic autoimmune thrombocytopenic purpura in adults: evidence for potentiating effect of vincristine.
Five adult patients with chronic autoimmune thrombocytopenic purpura (ATP) were given fresh frozen plasma infusion (FFP) as an alternative to intravenous gamma globulin (IV Ig). The effect of vincristine (VCR) and other agents given concomitantly is discussed and a synergistic phenomenon between VCR and FFP is proposed. This approach may provide a rational and economical alternative to the use of IV Ig in the treatment of chronic ATP in adults and it is hoped that a prospective trial can be initiated.
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000628:therapy*; D001379:Azathioprine / Q000627:therapeutic use; D001803:Blood Transfusion; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011241:Prednisone / Q000627:therapeutic use; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy / Q000628:therapy*; D013156:Splenectomy; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine; D001379:Azathioprine; D011241:Prednisone