[Calcinosis universalis with hyperphosphataemia--successful treatment with phosphorus deprivation].
Seven year old boy with calcinosis universalis associated with high serum phosphorus was reported. Over one year's treatment with aluminum hydroxide up to 18 grams per day have reduced calcified mass remarkably, while serum phosphorus levels were remaining still above the normal range. Concomitant use of probenecid seemed to be effective in reducing serum phosphorus levels as well as decreasing the calcified mass. Pathogenetic mechanisms of soft tissue calcification in calcinosis universalis is not clear, but in this case hyperphosphataemia is considered to be one important factor accelerating soft tissue calcification. Although hyperphosphataemia associated with tumoral calcinosis has been frequently observed, no report is yet available on calcinosis universalis associated with hyperphosphataemia. This case might represent one unique type of calcinosis.
D000536:Aluminum Hydroxide / Q000627:therapeutic use*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000097:blood / Q000473:pathology / Q000628:therapy*; D002648:Child; D003240:Connective Tissue Diseases / Q000097:blood / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D008297:Male; D010758:Phosphorus / Q000097:blood*; D011339:Probenecid / Q000627:therapeutic use*; D011859:Radiography
D010758:Phosphorus; D000536:Aluminum Hydroxide; D011339:Probenecid