[Protection of long-term ischemic kidneys from the damages of reoxygenation by using the temporary inhalation of a gas hypoxic mixture].
Experiments were carried out on 240 August and Wistar rats. It was shown that renal reperfusion after 2 h of ischemia, performed following 24-hour inhalation by the animals of a gas hypoxic mixture (GHM) with 10 to 12% O2, increased the survival rate of the rats and accelerated the resynthesis of adenine nucleotides by the kidneys as compared with analogous characteristics during reperfusion paralleled by inhalation of air or oxygen. The protective effect of GHM inhalation on renal function and metabolism was approximately the same as the protective action of high doses (240 mg/kg) of the antioxidant ionol. The experiments confirm the role of lipid peroxidation in the pathogenesis of reoxygenation injuries and the protective effect of GHM inhalation in the early period of reperfusion.
D000227:Adenine Nucleotides / Q000096:biosynthesis; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D007511:Ischemia / Q000378:metabolism / Q000628:therapy*; D007668:Kidney / Q000098:blood supply* / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D009584:Nitrogen / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000627:therapeutic use* / Q000633:toxicity*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000227:Adenine Nucleotides; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
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