A pharmacokinetic study of cefoperazone.
A pharmacokinetic study of cefoperazone on rats showed long half-life in serum and kidney. The most remarkable finding was that the drug was not detected in the fraction of mitochondria and lysosomes in all the experiment animals. The finding suggests the low nephrotoxic characteristics of cefoperazone.
D000818:Animals; D002438:Cefoperazone / Q000378:metabolism* / Q000633:toxicity; D002511:Cephalosporins / Q000378:metabolism; D006207:Half-Life; D007668:Kidney / Q000187:drug effects; D007700:Kinetics; D008247:Lysosomes / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D010406:Penicillins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002511:Cephalosporins; D010406:Penicillins; D002438:Cefoperazone