The role of antibody in protection against African swine fever virus.
Intraperitoneal immunization of pigs with anti-African swine fever virus (ASFV) antibody protected them against the effects of challenge with ASFV. This protection, which was exemplified by a reduction in pyrexia and viraemia plus an increased survival time, appeared to be mediated through the effects of complement-dependent antibody-mediated cytotoxicity (CDAC) or antibody dependent cell mediated cytotoxicity (ADCC). Experiments suggested that the reduction in viraemia was associated with complement lysis whereas protection was conferred by ADCC.
D000357:African Swine Fever / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D000358:African Swine Fever Virus / Q000276:immunology / Q000472:pathogenicity; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D007116:Immunization, Passive / Q000662:veterinary*; D013552:Swine; D014766:Viremia / Q000662:veterinary; D014774:Virulence
D000914:Antibodies, Viral