[Effect of nonachlazine on the temperature sensitivity of the lysosomal membranes of the heart muscle in rats in vitro].
It has been shown in vitro that nonachlazine stabilizes rat myocardial lysosomal membranes and activates total acid phosphatase in homogenates of rat myocardium. Preliminary addition of nonachlazine to homogenates in two different final concentrations produces unequal changes in total and free activity of acid phosphatase and cathepsin D during 2.5-hour incubation of homogenates at 37 degrees C.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002402:Cathepsin D / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D013696:Temperature; D013997:Time Factors
D010640:Phenothiazines; D009628:Nonachlazine; D000135:Acid Phosphatase; D002402:Cathepsin D
Vliianie nonakhlazina na temperaturnuiu chuvstvitel'nosti lizosomal'nykh membran serdechnoĭ myshtsy krys in vitro.