The effect of prostaglandin F2 alpha analog on the plasma concentration of progesterone in the bandicoot, Isoodon macrourus (Marsupialia:Peramelidae), during lactation.
Prostaglandin F2 alpha (PGF) analog was administered to bandicoots during lactation to determine whether PGF2 alpha is involved in the regression of the marsupial corpus luteum. The concentration of progesterone in the plasma, and the morphology of the corpus luteum were monitored following PGF analog treatment. When the drug was administered early in lactation, there was no apparent change in luteal function. However, when PGF analog was administered on Days 30 and 31 of lactation an immediate decrease in plasma progesterone concentration to 0.1 ng/ml was observed and regression of the corpora lutea was observed by Day 36. The corpus luteum of numerous eutherian species is resistant to the luteolytic effects of prostaglandin F2 alpha in the early luteal phase. The corpus luteum of the bandicoot appears to be resistant in a similar manner during early lactation.
D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D007774:Lactation / Q000187:drug effects; D008394:Marsupialia / Q000097:blood*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D013997:Time Factors
D011461:Prostaglandins F, Synthetic; D011374:Progesterone; D015237:Dinoprost; C010714:dinoprost tromethamine