Ocular tissues contain inhibitors of lymphocyte mitogenesis.
A fraction of bovine vitreous extract is a potent inhibitor of mitogen induced lymphocyte proliferation in vitro. Proliferation of lymphocytes induced in culture by lipopolysaccharide was more sensitive to inhibition by this fraction than were cultures of lymphocytes stimulated by Concanavalin A. We were unable to demonstrate such activity in similarly prepared fractions of cornea and lens.
D000818:Animals; D002417:Cattle; D003315:Cornea / Q000032:analysis; D005123:Eye / Q000032:analysis*; D005260:Female; D007908:Lens, Crystalline / Q000032:analysis; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D014020:Tissue Extracts / Q000494:pharmacology*; D014822:Vitreous Body / Q000032:analysis
D014020:Tissue Extracts