Age-dependent aminoglycoside nephrotoxicity.
Urinary N-acetyl-beta-D-glucosaminidase activity was examined in 41 patients who received a 5-day course of aminoglycoside. Both pretreatment N-acetyl-beta-D-glucosaminidase values and the increase in N-acetyl-beta-D-glucosaminidase after treatment were high in elderly groups, suggesting the increased vulnerability of the kidney with aging.
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000617:Aminoglycosides / Q000494:pharmacology / Q000633:toxicity; D003982:Dibekacin / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D005578:Fosfomycin / Q000494:pharmacology; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged
D000617:Aminoglycosides; D005578:Fosfomycin; D003982:Dibekacin; D007612:Kanamycin; D006596:Hexosaminidases; D000118:Acetylglucosaminidase