[Effect of the destruction of the brain serotoninergic system on the alcohol consumption by rats in the early periods of experimental alcoholism].
Albino noninbred rats were divided into groups, according to the duration of alcoholic anesthesia (4.5 g/kg i.p.), of predisposed (195.6 min) and non-predisposed (69.1 min) to voluntary intake of alcohol. Another group included animals screened for 21 days according to the level of intake of 15% ethanol under the conditions of free choice between alcohol and water (6.15 and 2.62 g/kg pure ethanol per day, respectively). The animals were subjected to electro-coagulation of the dorsal or magnus raphe nucleus or were injected with 5,6-dihydroxytryptamine--DNT (75 micrograms/microliters) into the ventricles of the brain. It was established that in rats non-predisposed to alcohol intake, the destruction of the raphe nuclei, of the dorsal in particular, or injection of DOT to animals with a weak alcoholic motivation produces a dramatic increase in alcohol intake. In alcohol intake predisposed rats and in animals with a high level of alcohol use, analogous exposures do not bring about any significant differences in alcohol intake. The data obtained indicate that the reduced serotonin content in the brain is associated with an increase in the level of alcoholic motivation.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D004198:Disease Susceptibility; D004564:Electrocoagulation; D006801:Humans; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D013997:Time Factors
D011985:Receptors, Serotonin; D015115:5,6-Dihydroxytryptamine
Vliianie destruktsii serotoninergicheskoĭ sistemy mozga na potreblenie alkogolia krysami na rannikh srokakh éksperimental'nogo alkogolizma.