title: [Methodological problems in researching chemical substances for their embryotoxic, teratogenic, hypotrophic and gonadotoxic action on agricultural animals].
abstract: The methodical problems in the study of chemicals with toxic, teratogenic, hypotrophic, and gonadotoxic effects on farm animals are tackled for the first time. With lab animals some new methodical interpretations are introduced in studying these chemical aftereffects with regard to farm animals. Determined has been the most sensitive animal species which can be used in such investigations. With sows it is suggested to perform cesarean section on the 50th or 80th day from the beginning of pregnancy, and not on the 1st or 2nd day prior to farrowing. With sheep the same is to be done on the 60th or 90th day. A method is also to be employed concerning a two-step successive castration with one and same animal. It makes it possible to follow up the dynamic of the effect of chemicals on the sexual function and the response of the germinative tissue in the processes of adaptation, compensation, and compensatory hyperfunction and hypertrophy.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D000829:Animals, Domestic; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006128:Growth / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D008722:Methods; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010053:Ovary / Q000187:drug effects*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013552:Swine; D013723:Teratogens / Q000633:toxicity*; D013737:Testis / Q000187:drug effects*; D013997:Time Factors
chemical_list: D009943:Organophosphorus Compounds; D013723:Teratogens
vernacular_title: Metodichni problemi pri izsledvane na khimichnite veshtestva za embriotoksichno, teratogenno, khipotrofichno i gonadotoksichno deĭstvie pri selskostopanski zhivotni.