[The diagnostic significance of short-time intravenous tests with human chorionic gonadotropin].
The normal response of testosterone synthesis to hCG has a biphasic pattern. After a short peak within four hours, there is a decrease followed by a second peak within 24 to 48 hours. In an endocrine system without other disturbances, the short-term reaction is a good parameter for Leydig cell function. We analyzed the short-term tests of 266 patients. Clinically normal persons (181) showed an increase of testosterone from 8.3 to 10.1 ng/ml after 2 hours. Similar levels were found in patients with varicocele, while men suffering from testicular hypoplasia responded by lower values (6.2 and 7.8 ng/ml). Patients with psychogenic impotence reacted significantly less (9.5 basally and 7.6 ng/ml after 2 h), whereas normal response was observed in patients with impotence due to hypertonus (9.0 to 11.0 ng/ml - n = 7). The comparison of our test results with the outcome of hormonal stimulation of spermatogenesis in oligozoospermia (n = 73) shows that better results are obtained if hCG produces a higher quotient. There have been no side effects of the test observed. In 81 patients, blood was tested at least 4 weeks later for the occurrence of hCG-antibodies; they were not demonstrable in any case. The short-term test is a simple, time-sharing method for testing of Leydig cell function.
D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology; D007172:Erectile Dysfunction / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009845:Oligospermia / Q000097:blood; D011863:Radioimmunoassay; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis / Q000187:drug effects; D013739:Testosterone / Q000097:blood; D014646:Varicocele / Q000097:blood
D006063:Chorionic Gonadotropin; D013739:Testosterone
Die diagnostische Bedeutung des intravenösen Kurzzeittests mit humanem Choriongonadotropin (hCG).