Rapid development of gouty tophi after diuretic therapy.
Increasing attention has been drawn to the role played by diuretics in the pathogenesis of gout, particularly in the elderly. We describe an elderly woman presenting acutely with tophus formation mimicking infection, in whom diuretic therapy was responsible for her disease. Her presentation with acutely inflamed tophi without any history of joint involvement, only 3 months after starting treatment, was highly unusual.
D000368:Aged; D004232:Diuretics / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000009:adverse effects* / Q000627:therapeutic use; D006073:Gout / Q000139:chemically induced* / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D014527:Uric Acid / Q000378:metabolism*
D004232:Diuretics; D014527:Uric Acid; D005665:Furosemide