title: Retinal manifestations of thrombotic thrombocytopenic purpura (TTP) following use of contraceptive treatment.
abstract: An 18-year old woman, suffering from thrombotic thrombocytopenic purpura (TTP) disease after taking an oral contraceptive, developed bilateral retinal elevations in the posterior pole with Elschnig spot formation without visual acuity impairment. Clinical and laboratory evaluation combined with intensive medical and surgical therapy (splenectomy) caused regression of the ocular and general findings. We believe that the ocular pathologic findings in this clinical case are due to injury in the choroidal vasculature and the pe layer as a manifestation of the TTP disease.
mesh_terms: D000293:Adolescent; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D009644:Norgestrel / Q000009:adverse effects*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000628:therapy; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology; D013156:Splenectomy
chemical_list: D003276:Contraceptives, Oral; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination