title: [A case of oral florid papillomatosis combined with gastroduodenal polyposis].
abstract: A 49-year-old man developing numerous papillary or partly cauliflower-like tumors over the lips, oral angles, gingiva and tongue starting 15 years earlier and associated with multiple gastroduodenal polyps of various sizes revealed by X-ray examination is presented. Histologically, the oral lesions consisted of marked proliferation of mature squamous cells without appreciable cellular atypism or submucosal invasion. Electron microscopic study failed to detect any virus-like particles, and negative reaction was obtained in immunohistological study for papilloma virus. The association of gastroduodenal polyposis with oral florid papillomatosis has appeared very rarely in the literature. Although the relationship between the two lesions remains unknown, it was assumed in the present case that all lesions would represent an entity of a hamartomatous nature.
mesh_terms: D004379:Duodenal Neoplasms / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D007417:Intestinal Polyps / Q000473:pathology*; D008048:Lip Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010212:Papilloma / Q000473:pathology*; D011127:Polyps / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology