[Clinical significance of urinary N-acetyl-beta-D-glucosaminidase activities in surgery].
Urinary N-acetyl-beta-D-glucosaminidase (U-NAG) activities were measured in 62 patients surgically treated in our clinic. The results obtained were as follows: The preoperative U-NAG activities were 9.53 +/- 8.63 IU/day in patients in elective operations, and 31.39 +/- 23.47 IU/day in cases in emergency surgery or exploratory laparotomies. The U-NAG activities were elevated slightly even in patients with no postoperative complications, suggesting there was significant damage to the renal tubular epithelium. In the patients with postoperative complications, the U-NAG activities were elevated markedly, especially in those with circulatory shock, suggesting severe damage to the renal tubular epithelium. Though the U-NAG showed abnormally high activities, the values of BUN, S-Cr, U-protein, UUN/BUN, FENa, Ccr, CH2O remained within the normal range. On the contrary, when they were abnormal, the U-NAG activities were not elevated. All patients, who showed high U-NAG activities with abnormal values of Ccr and/or CH2O, developed acute renal failure (ARF). In order to detect ARF in an early stage, Ccr and CH2O should be measured when U-NAG activities rose to over 50 IU/day.
D000118:Acetylglucosaminidase / Q000378:metabolism / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000652:urine; D004066:Digestive System Diseases / Q000652:urine; D004848:Epithelium / Q000503:physiopathology; D005260:Female; D006331:Heart Diseases / Q000652:urine; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007431:Intraoperative Complications / Q000652:urine; D007668:Kidney / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000652:urine; D011507:Proteinuria / Q000652:urine; D012120:Respiration Disorders / Q000652:urine; D013514:Surgical Procedures, Operative
D003404:Creatinine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase