Selective IgA deficiency in the dog.
This study documents the occurrence of selective IgA deficiency in the dog. This is a unique spontaneous animal model with clinical and immunologic findings similar to that of selective IgA deficiency in humans, the most common human primary immunodeficiency. The disease in the dog is characterized by chronic, recurrent respiratory infections and dermatitis, low concentrations of serum IgA, normal concentrations of serum IgG and IgM, normal T-cell function as measured by lymphocyte transformation tests, the presence of autoantibodies, and a defect in the maturation or terminal differentiation of IgA B cells into IgA-secreting plasma cells.
D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000032:analysis; D002908:Chronic Disease; D003872:Dermatitis / Q000276:immunology / Q000662:veterinary; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs / Q000276:immunology*; D005260:Female; D017098:IgA Deficiency; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000662:veterinary*; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology / Q000662:veterinary
D000954:Antigens, Surface