title: Capacitative transients in voltage-clamped epithelia.
abstract: In voltage-clamped epithelia the cell membrane potential transient during a + 10-mV transepithelial pulse conforms to the expected behavior for a series combination of two linear resistance-capacitance (RC) circuits. The evolution of the cell potential is characterized by a single time constant with values of 30-130 ms in frog skin and Necturus gallbladder. These observations have important consequences for the measurement of cell membrane resistance ratios and the interpretation of current-voltage relations.
mesh_terms: D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity / Q000187:drug effects; D004848:Epithelium / Q000502:physiology*; D005704:Gallbladder / Q000502:physiology*; D008433:Mathematics; D008564:Membrane Potentials; D008954:Models, Biological; D009337:Necturus; D011898:Ranidae; D012879:Skin Physiological Phenomena
chemical_list: D000584:Amiloride