title: Carpipramine metabolism in the rat, rabbit and dog and in man after oral administration.
abstract: Carpipramine administered orally is excreted via the urine and faeces in rat, rabbit, dog and man. Many metabolites are formed, including several conjugates in the urine. A total of 20-25 metabolites was detected by t.l.c. and h.p.l.c., 16 of which were isolated and identified. Three metabolic pathways were observed: hydroxylation of the iminodibenzyl ring to a phenol or alcohol without modification of the side-chain, hydroxylation of the terminal piperidine of the 2-piperidinol side-chain, and cyclization and dehydrogenation of the same 2-piperidinol group.
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D003984:Dibenzazepines / Q000378:metabolism*; D004285:Dogs / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008968:Molecular Conformation; D011817:Rabbits / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013045:Species Specificity; D013055:Spectrophotometry, Infrared; D014556:Urine / Q000032:analysis
chemical_list: D014151:Anti-Anxiety Agents; D003984:Dibenzazepines; D001569:Benzodiazepines; C006922:carpipramine