Clearance of intravitreal 3H-fluorouracil.
The clearance of intravitreally administered 5-fluorouracil (5-FU) was studied under five experimental conditions. The same nontoxic dose resulted in similar initial intravitreal concentrations and cleared rapidly from all eyes (approximately 90% clearance within eight hours). Half-life values ranged from 46 to 168 minutes. The longest half-life occurred in aphakic-vitrectomized eyes in which hyaluronic acid (Healon) was substituted for vitreous (168 minutes). A similar half-life was found in normal eyes (150 minutes). The shortest half-life occurred in aphakic-vitrectomized eyes postoperatively (46 minutes). Intermediate half-life values occurred in vitrectomized but phakic eyes postoperatively (67 minutes) and in aphakic-vitrectomized "quiet" eyes (at least two weeks postoperatively) (82 minutes).
D000818:Animals; D005472:Fluorouracil / Q000378:metabolism*; D006207:Half-Life; D006820:Hyaluronic Acid / Q000378:metabolism; D007700:Kinetics; D007908:Lens, Crystalline / Q000601:surgery; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism*
D006820:Hyaluronic Acid; D005472:Fluorouracil