[Interaction of liposomes with a varying lipid composition with hepatocytes in vitro].
Interaction of liposomes from egg lecithin, phospholipids and gangliosides of rat liver with rat hepatocyte monolayers was investigated. It was shown that liposomes from phospho- and glycolipids of the liver were bound by rat hepatocytes to a far greater degree than lecithin liposomes. Liver gangliosides increased active endocytosis of liposomes by hepatocytes. Preincubation of hepatocytes with gangliosides reduced the binding of phosphoglycolipid liposomes by those cells.
D000818:Animals; D002478:Cells, Cultured; D004347:Drug Interactions; D004705:Endocytosis / Q000187:drug effects; D005732:Gangliosides / Q000378:metabolism; D007460:Iodoacetamide / Q000494:pharmacology; D050356:Lipid Metabolism; D008081:Liposomes / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats
D005732:Gangliosides; D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; D007460:Iodoacetamide
Vzaimodeĭstvie liposom s razlichnym lipidnym sostavom s kletkami gepatotsitov in vitro.