New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results.
Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003543:Cysteamine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*
D009607:Nitrosourea Compounds; D003543:Cysteamine