Observations on the dissolution behavior of a tablet formulation: effect of compression forces.
Two test drugs, hydrochlorothiazide and phenylbutazone, were separately incorporated into a standard formulation to study their disintegration and dissolution properties as a function of compression force. The increase in dissolution with force was attributed to the manner in which tablets disintegrated while dissolving. At a fixed press setting, tablets from the same compression cycle showed variations in their dissolution which were in agreement with the observed effects of force on dissolution. A linear correlation between dissolution efficiency and the logarithm of force was found to exist over the compression range studied.
D004339:Drug Compounding; D006244:Hardness; D010653:Phenylbutazone / Q000032:analysis; D011208:Powders; D011312:Pressure; D012995:Solubility; D013607:Tablets
D011208:Powders; D013607:Tablets; D010653:Phenylbutazone