Pharmacokinetics of propylene glycol in humans during multiple dosing regimens.
The pharmacokinetics of propylene glycol has been examined during multiple oral-dosing regimens. The glycol is rapidly absorbed, with Cpmax observed within 1 h following administration. The terminal elimination half-life is approximately 4 h. After a minimum of 10 half-lives of maintenance dosing on a fixed regimen, the accumulation of propylene glycol differed significantly among individuals because of variability in apparent clearance. The average apparent total body clearance is approximately 0.1 L/kg X h and may be concentration dependent. The apparent volume of distribution is approximately 0.5 L/kg, approximating total body water.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000378:metabolism; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000378:metabolism*
D011409:Propylene Glycols; D010672:Phenytoin; D019946:Propylene Glycol