Potential anticancer agents--nitroxyl derivatives of Rubomycin.
Two new of the spin-labeled analogues of Rubomycin were studied. It was shown that spin-labeled derivatives were less toxic than the parent compound and had a broad-spectrum antitumor activity. Spin-labeled derivative was clearly less cardiotoxic in the rat model than Rubomycin (Daunorubomycin).
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity; D003630:Daunorubicin / Q000031:analogs & derivatives*; D006321:Heart / Q000187:drug effects; D051379:Mice; D051381:Rats; D013113:Spin Labels / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D013113:Spin Labels; D003630:Daunorubicin