Chemical and biological properties of a cationic Tc-tetraamine complex.
The complex of 99Tc with the ligand 1,4,8,11-tetraazaundecane (2,3,2-tet) was prepared and was compared with the similar 99Tc complexes with ethylenediamine and 1,4,8,11-tetraazacyclotetradecane. The results are all consistent with the formula [TcO2(2,3,2-tet)]+. The biological behavior was tested with 99mTc in Wistar rats. A fast clearance via the kidneys was found, and no accumulation in any other organ was observed.
D000818:Animals; D005029:Ethylenediamines; D005260:Female; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D007553:Isotope Labeling / Q000379:methods; D015609:Organotechnetium Compounds; D011073:Polyamines; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium; D014018:Tissue Distribution
D005029:Ethylenediamines; D006571:Heterocyclic Compounds; D006573:Heterocyclic Compounds, 1-Ring; D015609:Organotechnetium Compounds; D011073:Polyamines; C045774:technetium Tc 99m 1,4,8,11-tetraazaundecane; C045773:technetium Tc 99m cyclam; C032997:technetium Tc 99m ethylenediamine; D013667:Technetium