Norepinephrine turnover and voluntary consumption of ethanol in the rat.
The effect of a centrally acting noradrenergic agonist on voluntary ethanol intake was investigated in the laboratory rat. Doses of 1.5, 7.5, 15 and 25 mg/kg of FLA-136 were administered to animals chronically exposed to ethanol on a free choice basis. Administration of the highest dose of the drug brought about a 40% reduction in voluntary ethanol intake with no significant effect on total fluid consumption. These results would seem to indicate a possible functional relationship between rate of norepinephrine turnover and amounts of ethanol voluntarily consumed by the laboratory rat.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use
D014230:Triazoles; C014891:FLA-136; D009638:Norepinephrine