[Regulating role of the microtubule system in the distribution of actin microfilament bundles in embryonic fibroblasts].
The effect of colcemid on the distribution of actin microfilament bundles in the mouse embryo fibroblasts was studied using immunomorphological methods. In the control fibroblasts, microfilament bundles usually cross the entire cell and are oriented in parallel to the stable edges of the cell. In the colcemid-treated cells there are several groups of bundles. In each group all bundles are oriented in the same direction but these directions do not depend on the cell shape. Besides, bundles in the colcemid-treated cells are shorter than in the control cells. Microtubules are suggested to control the organization of action bundles.
D000199:Actins / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure*; D003703:Demecolcine / Q000494:pharmacology; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D008809:Mice, Inbred C3H; D008870:Microtubules / Q000187:drug effects / Q000648:ultrastructure*; D013997:Time Factors
D000199:Actins; D003703:Demecolcine
Reguliruiushchaia rol' sistemy mikrotrubochek v raspredelenii puchkov aktinovykh mikrofilamentov v émbrional'nykh fibroblastakh.