Mycotic endophthalmitis caused by Penicillium sp. after parenteral drug abuse.
A 30-year-old man developed endophthalmitis three weeks after an intravenous injection of hydromorphone hydrochloride. Penicillium species was recovered from a vitreous aspirate. Treatment with amphotericin B and flucytosine resulted in documented sterilization of the vitreous. At a six-month follow-up examination, the visual acuity of the involved eye was still limited to light perception.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009181:Mycoses / Q000382:microbiology; D010202:Panophthalmitis / Q000188:drug therapy / Q000209:etiology*; D010407:Penicillium / Q000302:isolation & purification*; D011241:Prednisone / Q000627:therapeutic use; D019966:Substance-Related Disorders / Q000150:complications*
D000935:Antifungal Agents; D000666:Amphotericin B; D011241:Prednisone