title: [Toxicological study of the Soviet tetracyclic antidepressant inkazan].
abstract: The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000506:poisoning / Q000633:toxicity*; D001773:Blood Cells / Q000187:drug effects; D001786:Blood Glucose / Q000032:analysis; D002243:Carbolines / Q000506:poisoning / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D007099:Imipramine / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D001786:Blood Glucose; D002243:Carbolines; C027473:metralindole; D007099:Imipramine; D004837:Epinephrine
vernacular_title: Toksikologicheskoe izuchenie otechestvennogo tetratsiklicheskogo antidepressanta inkazana.