Effects of intraventricular angiotensin II on heat balance at various ambient temperatures in rats.
Angiotensin II (AII, 5 micrograms) injected into the cerebral ventricles produced hypothermia in conscious rats at ambient temperatures (Ta) of 18, 23, and 28 degrees C. At Ta of 18 and 23 degrees C, AII-induced hypothermia was attributed to both enhancement of heat loss and suppression of metabolic rate. At Ta of 28 degrees C, AII-induced hypothermia seemed to be mainly attributed to increased heat loss.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D003106:Colon / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D000804:Angiotensin II