title: Antibacterial sesquiterpene aryl esters from Armillaria mellea.
abstract: Investigation of the mycelial extract of Armillaria mellea led to the isolation of the known melleolide (2a) and two new sesquiterpene aryl eters, 4-O-methylmelleolide (2b) and judeol (1c). Their structures were deduced from spectral data and that of (2b) confirmed by X-ray analysis. The new esters (1c) and (2b) showed strong antibacterial activity against gram-positive bacteria.
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000032:analysis / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D012717:Sesquiterpenes