The embryotoxic and osteolathyrogenic effects of semicarbazide.
The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/l while the 96-h EC50 is 76.28 mg/l. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The major malformation is associated with the notochord where the notochordal sheath is reduced owing to the disruption in the maturation and/or deposition of the connective tissue fibers.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D003238:Connective Tissue / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008854:Microscopy, Electron; D012663:Semicarbazides / Q000633:toxicity*; D013723:Teratogens; D014332:Tropocollagen / Q000378:metabolism; D014333:Tropoelastin / Q000378:metabolism; D014982:Xenopus laevis
D012663:Semicarbazides; D013723:Teratogens; D014332:Tropocollagen; D014333:Tropoelastin; C010059:carbamylhydrazine