[Comparative evaluation of the effect of immunostimulants on the dehydrogenase activity of the mouse thymus].
Comparative biochemical estimation of the influence of yeast RNA, prodigiosan and levamisole on the activity of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase in the thymus of mice was carried out. It was shown that the immunostimulants induced different qualitative and quantitative changes in the activity of the enzymes. Administration of yeast RNA resulted in activation of lactate dehydrogenase, malate dehydrogenase and glutamate dehydrogenase. Prodigiosan increased the activity of lactate dehydrogenase and glutamate dehydrogenase but not that of malate dehydrogenase. The action of levamisole was characterized by long-term activation of glutamate dehydrogenase. The possible mechanisms of the influence of these drugs on the metabolic activity of the thymus are discussed.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007978:Levamisole / Q000494:pharmacology; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D051379:Mice; D010088:Oxidoreductases / Q000378:metabolism*; D011354:Prodigiozan / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D012331:RNA, Fungal; D007978:Levamisole; D011354:Prodigiozan; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005969:Glutamate Dehydrogenase
Sravnitel'naia otsenka vliianiia immunostimuliatorov na aktivnost' nekotorykh degidrogenaz timusa mysheĭ.