[A clinical study on the penetration of aspoxicillin into tissue and wound exudates in breast cancer].
Penetration of aspoxicillin (ASPC), a new semisynthetic penicillin of broad spectrum, into normal and cancer tissue and wound exudate were examined in breast cancer. ASPC was administered by single injection of 1 or 2 g. The concentration of ASPC in the resected skin, normal mammary gland and cancer were similar to their serum levels, when ASPC was administered before radical mastectomy. ASPC concentration in the wound exudate which was collected from the inserted drains into the resected area reached the maximum at 3 approximately 4 hours after the injection at the levels of 19.4 micrograms/ml (1 g) and 35.1 micrograms/ml (2 g). The level decreased gradually by maintained still high at 3.7 micrograms/ml (1 g) and 11.4 micrograms/ml (2 g) even 8 hours after the injection. From these results it may be expected that ASPC is a useful penicillin in the breast surgery.
D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001940:Breast / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000601:surgery; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D011292:Premedication; D012867:Skin / Q000378:metabolism*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; C037485:aspoxicillin; D000658:Amoxicillin