Lowering of liver acetaldehyde but not ethanol concentrations by pretreatment with taurine in ethanol-loaded rats.
A rise in blood and liver acetaldehyde concentrations following ethanol loading (1.5 g/kg b.wt) was significantly reduced when rats were pretreated orally with taurine (0.5 g/kg), a potent in vitro activator of yeast aldehyde dehydrogenase. This taurine pretreatment produced a 4-fold increase in liver taurine content.
D000079:Acetaldehyde / Q000097:blood / Q000378:metabolism*; D000437:Alcoholism / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
D013654:Taurine; D000431:Ethanol; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde