title: Amino acid sequences of the carboxyl-terminal regions of rat plasma fibrinogen gamma A and gamma' chains.
abstract: Amino acid sequence analysis of human fibrinogen gamma' chains have shown that the larger size relative to the gamma A chains is due to differences at the COOH-terminus. As shown by DNA sequencing, these differences as well as those in rat fibrinogen gamma' and gamma A chains result from differential processing of the primary mRNA transcript. We isolated and sequenced carboxyl-terminal CNBr peptides from gamma' and gamma A chains. As predicted by DNA sequencing, the gamma A peptide has the carboxyl-terminal sequence Gly-Gly-Ser-Lys Gln-Val-Gly-Asp-Met-COOH. The gamma' peptide is identical through residue 6 and terminates with Ser-Val-Glu-His-Glu-Val-Asp-Val-Glu Tyr-Pro-COOH.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003488:Cyanogen Bromide; D005340:Fibrinogen / Q000235:genetics; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
chemical_list: D012333:RNA, Messenger; D005340:Fibrinogen; D003488:Cyanogen Bromide