Synthesis of some new amidine derivatives as potent hypoglycemic agents.
A series of S-arylformamidino-N-(alkyl/arylisothiourea) Cyclicamino dihydrochlorides were synthesised and screened for their hypoglycemic activity in normal as well as alloxanized diabetic rats. Some of the compounds (Id, Ie, Ih-1) showed more than 30% lowering of blood sugar level of Albino rats.
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship
D000578:Amidines; D001786:Blood Glucose; D007004:Hypoglycemic Agents