Response to gallamine: an indicator of diminished neuromuscular function in experimental autoimmune myasthenia gravis.
A test for diminished neuromuscular function in animals with experimental autoimmune myasthenia gravis is described. Within minutes following an injection of gallamine triethiodide, mice exhibit a dramatic yet transient response which is dose-dependent. Mice previously inoculated with acetylcholine receptor are approximately twice as sensitive to gallamine as normal mice. Positive results have been found in over 80% of receptor-inoculated BALB/c mice and in 94% of C57Bl/6 mice.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000503:physiopathology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D005080:Exercise Test; D005703:Gallamine Triethiodide; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009046:Motor Neurons / Q000502:physiology; D009157:Myasthenia Gravis / Q000503:physiopathology*; D011930:Reaction Time; D011950:Receptors, Cholinergic / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology*
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D005703:Gallamine Triethiodide