Cytodestructive mechanisms provoked by food antigens: III. Inhibition of direct and antibody-dependent allergic autocytotoxicity (ACT) by ketotifen.
In vitro challenge of peripheral white blood cells (WBC) from 15 food sensitive individuals and 16 asymptomatic controls was studied in allergic autocytotoxicity (ACT) assay using extracts of cow's milk, corn, and wheat. The observed disintegration of the WBC in the direct and antibody-dependent ACT was inhibited by ketotifen in a linear, dose-dependent manner. Therefore, our data demonstrate that the ACT response is associated with anaphylactic injury which is prevented by pretreatment with ketotifen, in vitro.
D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D000941:Antigens / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D005502:Food; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007665:Ketotifen / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008875:Middle Aged
D000941:Antigens; D007665:Ketotifen