Rabbit lung after inhalation of manganese chloride: a comparison with the effects of chlorides of nickel, cadmium, cobalt, and copper.
Rabbits were exposed to aerosols of MnCl2 (mass median aerodynamic diameter 1 micron) in metal concentrations of 1.1 and 3.9 mg/m3 for 4-6 weeks, 5 days/week, 6 h/day. The effects of alveolar type II cells, phospholipids, alveolar macrophages, and lung structure in general were compared with earlier reported effects of Ni2+, Cd2+, Cu2+, and Co2+. Except for a significant increase in the diameter of the alveolar macrophages after exposure to the higher Mn2+ concentration, no abnormalities were seen. The results of this and earlier studies indicate that these five metal ions have different, specific effects on the alveolar part of the lung.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002712:Chlorides; D003035:Cobalt / Q000633:toxicity*; D003300:Copper / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008264:Macrophages / Q000187:drug effects; D008297:Male; D017895:Manganese Compounds; D020149:Manganese Poisoning; D008854:Microscopy, Electron; D009532:Nickel / Q000633:toxicity*; D010087:Oxides; D010743:Phospholipids / Q000032:analysis; D011817:Rabbits
D002712:Chlorides; D017895:Manganese Compounds; D010087:Oxides; D010743:Phospholipids; D002104:Cadmium; D003035:Cobalt; C027424:manganese oxide; C022838:nickel chloride; D003300:Copper; D009532:Nickel; C018021:cobaltous chloride; D019256:Cadmium Chloride; C025340:manganese chloride; C029892:cupric chloride