Stress, adrenals, and vitamin C.
Large daily doses of vitamin C maintained high levels of corticosteroids in the blood of stressed mice. Of these corticosteroids, glucocorticoid is known to suppress the immune response. It is hypothesized that large doses of vitamin C may reduce the organism's immunity to disease when stress is present.
D000302:Adrenal Cortex / Q000502:physiology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D051379:Mice; D013312:Stress, Physiological / Q000097:blood* / Q000276:immunology
D001205:Ascorbic Acid; D003345:Corticosterone