[Effect of phytoecdisteroids and anabolic steroids on liver mitochondrial respiration and oxidative phosphorylation in alloxan diabetic rats].
Administration of phytoecdisteroides ecdisterone and turkesterone in the dose of 5 mg/kg and anabolic steroid preparation nerobol in the dose 10 mg/kg in rats with experimental diabetes removes the activation of respiration under all metabolic conditions of rats liver mitochondria revealing at given pathology. The normalized effect of phytoecdisteroides on the cells energetic processes is observed on the 7th day of the administration. The same effect of nerobol is revealed at more prolonged (15 days) administration.
D045930:Anabolic Agents / Q000627:therapeutic use*; D000818:Animals; D002783:Cholestenones / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004441:Ecdysterone / Q000627:therapeutic use / Q000031:analogs & derivatives; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D008696:Methandrostenolone / Q000627:therapeutic use; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D045930:Anabolic Agents; D002783:Cholestenones; D010936:Plant Extracts; D004441:Ecdysterone; C017787:turkesterone; D008696:Methandrostenolone
Vliianie fitoékdisteroidov i steranabolov na dykhanie i okislitel'noe fosforilirovanie mitokhondriĭ pecheni krys pri alloksanovom diabete.