Lesions of the inferior olive increase glutamic acid decarboxylase activity in the deep cerebellar nuclei of the rat.
Inferior olive-climbing fiber lesions were made by administering 3-acetylpyridine to 16-day-old rats. This treatment produced multiple motor abnormalities which gradually improved over the subsequent 28 days. A significant increase in glutamic acid decarboxylase (GAD) activity was found in the deep cerebellar nuclei 24 h after treatment. This elevation increased with time, reaching 134% of control values 28 days after treatment. GAD activity in the cerebellar vermis also increased but did so more slowly and to a lesser degree than in the deep nuclei, reaching 114% of control values 28 days after treatment. The results suggest the operation of different mechanisms in producing the increased GAD activity in the different areas.
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced; D002529:Cerebellar Nuclei / Q000201:enzymology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology; D009847:Olivary Nucleus / Q000187:drug effects / Q000502:physiology*; D011689:Purkinje Cells / Q000502:physiology; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011725:Pyridines; C010835:3-acetylpyridine; D005968:Glutamate Decarboxylase