Anti-macrophage antiserum in the treatment of experimentally induced incontinentia pigmenti histologica.
To facilitate the removal of dermal melanin which is located in melanophages of the skin, we studied the effect of anti-macrophage antiserum on the elimination of dermal melanin in incontinentia pigmenti histologica. Although a pronounced inflammatory reaction was produced at the sites injected with the antiserum, no significant decrease in the amounts of radioactive melanosomes was observed at the injected sites. The failure of the intradermal injection of the antiserum to remove melanin pigment could have been due to the very low mobility of the newly recruited macrophages.
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D008264:Macrophages / Q000276:immunology; D008297:Male; D008547:Melanophores / Q000378:metabolism; D010859:Pigmentation Disorders / Q000628:therapy*; D011817:Rabbits
D000906:Antibodies