Local transfer of delayed-type hypersensitivity after Salmonella infection in mice.
An adoptive local transfer system has been used to study the mediators of delayed-type hypersensitivity induced in mice by infection with Salmonella enteritidis 11RX. The cells which transfer this state of hypersensitivity to untreated recipients are nonadherent T lymphocytes with the surface phenotype Lyt 1+2-, and successful transfer requires compatibility at the I-A subregion of the H-2 complex. In these and other respects these cells are indistinguishable from those previously found to be responsible for in vitro lymphokine release upon culture with 11RX antigens.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007116:Immunization, Passive; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010641:Phenotype; D012480:Salmonella Infections / Q000276:immunology*
D003524:Cyclosporins