A unique case of sarcoidosis with coexistent collagen vascular disease. Possible result of a compatible disease-sustaining immunologic environment.
A patient presented with dysphagia, arthralgias, and a peculiar skin eruption characterized by histopathologic features of sarcoidal granulomas and lupus erythematosus occurring in the same lesion. Sarcoidal granulomas were also found in skeletal muscle. The unique histopathologic features of this case suggest that coexistence of sarcoidosis with autoimmune collagen vascular diseases may be more than coincidence. A review of the immunologic status of patients with sarcoidosis and autoimmune collagen vascular disorders is presented with speculations on the relevance of potential disease-sustaining immunologic patterns of both groups of diseases.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D003095:Collagen Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007109:Immunity; D008264:Macrophages / Q000276:immunology; D008297:Male; D012507:Sarcoidosis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014652:Vascular Diseases / Q000150:complications / Q000276:immunology* / Q000473:pathology
D000305:Adrenal Cortex Hormones