Pharmacokinetic evidence for blood flow depression in dose dependent disposition of 4-aminoantipyrine in rabbits.
Pharmacokinetic relationships have been developed to characterize a one-compartment drug disposition model which includes perfusion limited elimination processes. The derived expressions have been applied to plasma concentration and urinary excretion data obtained after rapid intravenous administration of 4-aminoantipyrine to rabbits. The mathematical relationships and experimental data demonstrate that dose dependent disposition of 4-aminoantipyrine is a result of reduced renal and hepatic blood flow caused by the drug itself.
D000675:Ampyrone / Q000378:metabolism*; D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives*; D001798:Blood Proteins / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010477:Perfusion; D011485:Protein Binding; D011817:Rabbits; D012079:Renal Circulation
D001798:Blood Proteins; D000675:Ampyrone; D000983:Antipyrine