[Analgesic effect, tolerance development and dependence potential of D-phenylalanine].
In comparison to well-established non-narcotic analgetics, the amino acid D-phenylalanine produces similar, dose-dependent analgesic effects in animal experiments, but acts significantly longer. Neither a tolerance of mice to D-Phe after administration for 10 d nor a development of drug dependence in rats following treatment for 6 weeks could be regarded.
D000085:Acetates; D000700:Analgesics; D000818:Animals; D004361:Drug Tolerance; D004558:Electric Stimulation; D051379:Mice; D010649:Phenylalanine / Q000494:pharmacology*; D019966:Substance-Related Disorders; D013997:Time Factors
D000085:Acetates; D000700:Analgesics; D010649:Phenylalanine
Analgetische Wirkung, Toleranzentwicklung und Abhängigkeitspotential von D-Phenylalanin.