Spectrophotometric analysis of mixtures of acetaminophen, salicylamide, and codeine phosphate in tablets.
A simple and accurate spectrophotometric procedure for the analysis of a mixture of acetaminophen, salicylamide, and codeine phosphate is described. Determination of the first 2 components depends on pH-induced differential spectral changes of their nitroso derivatives. The third component is assayed by the acid dye method. The proposed procedure was successfully applied to the analysis of laboratory-made and commercial tablets containing the ternary drug mixture.
D000082:Acetaminophen / Q000032:analysis*; D003061:Codeine / Q000032:analysis*; D004338:Drug Combinations; D012457:Salicylamides / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D004338:Drug Combinations; D012457:Salicylamides; D013607:Tablets; D000082:Acetaminophen; C031060:salicylamide; D003061:Codeine