[Prognostic value of determining the succinate dehydrogenase activity of lymphocytes and the therapeutic effectiveness of sodium succinate in resuscitation of rats].
In the experiments on male rats recovered after clinical death caused by acute hemorrhage and mechanical asphyxia undulatory changes of lymphocyte succinate dehydrogenase activity were revealed: enzyme inhibition during clinical death, activation in the first minutes of resuscitation with subsequent moderate reduction in activity. Lymphocyte succinate dehydrogenase activity was shown to be a reliable prognostic criterion. Pre-injection of sodium succinate at a dose of 20 mg/kg improved considerably the resuscitation results especially during the first two days of rehabilitation period.
D000818:Animals; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D011379:Prognosis; D051381:Rats; D012151:Resuscitation; D013385:Succinate Dehydrogenase / Q000097:blood*; D013386:Succinates / Q000627:therapeutic use*; D019802:Succinic Acid
D013386:Succinates; D019802:Succinic Acid; D013385:Succinate Dehydrogenase
Prognosticheskaia tsennost' opredeleniia aktivnosti suktsinatdegidrogenazy limfotsitov i terapevticheskaia éffektivnost' suktsinata natriia pri ozhivlenii krys.