Direct-calibration method for determination of aluminum in serum is comparable with the protein-precipitation technique.
We compared results by two methods for serum Al determination: matrix modification with direct calibration in a stabilized-temperature platform furnace (Clin Chem 28, 2139, 1982) and a technique involving extraction with nitric acid before atomic absorption spectrometry (Clin Chem 30, 1216, 1984). The two methods gave similar results with use of either a deuterium or a Zeeman system of background correction, but gave different slopes for standard additions (mA X s per microgram/L), depending on the Al content of the serum, an effect not seen with aqueous solutions. These differences do not affect the accuracy of the Al determination up to 150 micrograms/L.
D000535:Aluminum / Q000097:blood*; D001798:Blood Proteins; D002138:Calibration; D011232:Chemical Precipitation; D003903:Deuterium; D006801:Humans; D013054:Spectrophotometry, Atomic / Q000379:methods
D001798:Blood Proteins; D003903:Deuterium; D000535:Aluminum