[Enhancement of ionizing radiation effects on transplantable cerebral gliomas using short-term hyperglycemia].
Experiments were staged on rats with transplantable anaplastic cerebral right hemisphere astrocytomas. Hyperglycemia was induced by means of intraperitoneal fractional administration of 40% glucose solution. Single local x-ray tumor irradiation followed on the 4-5th, 7-8th and 10-12th days after strain transplantation at the doses of 30 and 40 Gy without hyperglycemia and in combination with it. The irradiation effect was assessed by the mean survival time of the animals. Hyperglycemia was shown to increase significantly radiation injury of highly resistant experimental malignant cerebral glial tumors.
D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000532:radiotherapy*; D005947:Glucose / Q000008:administration & dosage*; D009368:Neoplasm Transplantation; D051381:Rats
D005947:Glucose
Usilenie éffekta deĭstviia ioniziruiushchego izlucheniia na perevivnye gliomy golovnogo mozga posredstvom kratkovremennoĭ giperglikemii.