[Orientation and kinetics of surface denaturation of normal human and myeloma IgA in monolayers at the interface of air-NaCl aqueous solutions].
Normal serum immunoglobulin A (IgA) and abnormal IgA isolated from serum of patients with multiple A-myeloma have been studied by monolayer technique at air--NaCl solution interfaces. Normal IgA analogous to human normal IgG and secretory IgA was shown to have horizontal orientation at air--water interface. Only some abnormal IgA were similar to myeloma IgG and differed from the normal ones by their orientation at phase border. Majority of myeloma IgA under study could not be distinguished from the normal ones by orientation and denaturation kinetics at interface. B-lymphocytes of the first group of patients were assumed to carry IgA-receptors at their surface, but B-lymphocytes of the second group of patients carried Ig receptors of some other class of immunoglobulins.
D000388:Air; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007700:Kinetics; D009194:Myeloma Proteins / Q000032:analysis*; D011489:Protein Denaturation; D012965:Sodium Chloride; D012996:Solutions
D007070:Immunoglobulin A; D009194:Myeloma Proteins; D012996:Solutions; D012965:Sodium Chloride
Orientatsiia i kinetika poverkhnostnoĭ denaturatsii normal'nykh i mielomnykh IgA cheloveka v monomolekuliarnykh sloiakh na granitse faz vodnye rastvory NaCl-vozdukh.