Changes of energy metabolism, myosin light chain composition, lactate dehydrogenase isozyme pattern and fibre type distribution of denervated fast-twitch muscle from rabbit after low frequency stimulation.
The influence of low frequency (8-10 Hz) electrical stimulation on denervated fast-twitch muscle from rabbit was investigated. Prolonged direct stimulation of denervated muscle resulted in higher oxidative enzyme activities. Furthermore, single fibre analyses for succinate dehydrogenase showed a more uniform distribution of activity in stimulated-denervated muscle when compared to normal muscle. As was also the case following stimulation of innervated muscle, glycolytic enzymes were decreased in activity and the LDH-isozyme pattern was also shifted towards heart type. No change of the myosin light chain pattern could be observed after 56 days of stimulation.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004558:Electric Stimulation; D004734:Energy Metabolism; D006651:Histocytochemistry; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D009121:Muscle Denervation; D009132:Muscles / Q000201:enzymology / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D011817:Rabbits
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D009218:Myosins