title: Staphylococcus aureus Tour, a selectively mouse-pathogenic strain for experimental chemotherapeutic study (a note).
abstract: Staphylococcus aureus Tour is a unique strain. It is highly pathogenic to mice but not to other laboratory animals and primates. This selective pathogenicity makes it useful for experimental chemotherapeutic studies. Since it is highly specialized for mice, it imitates the natural course of infection and produces death after intraperitoneal infection of a relatively few cells even when suspended in isotonic saline. This strain has been found to be very sensitive (MIC's) to various beta-lactams and gentamicin as well as useful for infection-protection studies in mice (ED50's) with a series of cephalosporins.
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; D005839:Gentamicins; D010406:Penicillins