title: Genetic instability in the development of drug resistance.
mesh_terms: D002478:Cells, Cultured; D002999:Clone Cells / Q000187:drug effects / Q000473:pathology; D004351:Drug Resistance; D005784:Gene Amplification; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D014162:Transfection
chemical_list: D013762:Tetrahydrofolate Dehydrogenase