title: Are there valid reasons for using anti-muscarinic drugs in the management of renal colic?
abstract: Experiments have been carried out with isolated ring preparations of human ureter. The tissue displayed spontaneous activity and contracted when exposed to barium chloride (0.5-4 mM) but no responses were obtained with carbachol (0.1 micromolar-0.1 mM). This raises questions about the value of treating ureteric colic with anti-muscarinic drugs.
mesh_terms: D001464:Barium / Q000494:pharmacology*; D017609:Barium Compounds; D002217:Carbachol / Q000494:pharmacology*; D002712:Chlorides; D003085:Colic / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000188:drug therapy; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000627:therapeutic use; D014513:Ureter / Q000187:drug effects*
chemical_list: D017609:Barium Compounds; D002712:Chlorides; D010276:Parasympatholytics; C024986:barium chloride; D001464:Barium; D002217:Carbachol