title: Prevention of coccidiosis in domestic dogs and captive coyotes (Canis latrans) with sulfadimethoxine-ormetoprim combination.
abstract: Sulfadimethoxine-ormetoprim combination was evaluated as a coccidiostat against experimentally induced coccidiosis in young dogs and coyotes (Canis latrans). The animals were experimentally inoculated with 50,000 or 100,000 sporulated oocysts of Isospora ohiohensis (98%) and Isospora canis (2%). In experiment 1, daily treatment for 13 to 23 days with a combination of 27.5 mg of sulfadimethoxine/kg of body weight (BW) and 5.5 mg of ormetoprim/kg of BW admixed to the feed resulted in no significant (P greater than 0.05) difference in fecal oocyst counts between treated and nontreated groups of dogs or coyotes. In experiment 2, treatment with a combination of 55 mg of sulfadimethoxine/kg of BW and 11 mg of ormetoprim/kg of BW for 23 days was 99.8% effective against Isospora spp infections in dogs. Significantly (P less than 0.05) fewer oocysts were present in feces of treated dogs than were present in feces of nontreated dogs from first passage of oocysts at day 4 to the end of the patent period at days 19 to 21. After the 2nd week of treatment, BW of treated dogs were significantly greater (P less than 0.05) than BW of nontreated dogs. Evidence of drug toxicity was not observed clinically or by serum chemical analyses.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002335:Carnivora; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary*; D003967:Diarrhea / Q000517:prevention & control / Q000662:veterinary; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D007549:Isospora / Q000302:isolation & purification; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D013412:Sulfadimethoxine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D011743:Pyrimidines; D013412:Sulfadimethoxine; C100125:ormetoprim