[Effect of serotonin on proliferating and resting cells in culture].
The influence of exogenous serotonin on cell division of L929 and L-41 cell strains has been investigated under various conditions of cell growth in culture (the incubation either in 10% serum medium without changing the medium, or in the medium with 0.5% serum). The data obtained show that serotonin in physiological concentration (10(-7) M) stimulates proliferation of resting cells. In proliferating cells, compared to resting ones, the sensitivity to exogenous amine appeared statistically non-significant. Exogenous serotonin is suggested to be a proliferating stimulus for resting cells.
D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D007739:L Cells / Q000187:drug effects; D007938:Leukemia / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D012701:Serotonin / Q000494:pharmacology*; D013268:Stimulation, Chemical
D012701:Serotonin
Vliianie serotonina na proliferiruiushchie i pokoiashchiesia kletki v kul'ture.