[Common variable hypogammaglobulinemia. Apropos of a new case].
The authors report the case of a 17 year-old girl who presented with typical clinical features (pneumonia, sinusitis, otitis and diarrhoea) of Variable Primary Hypogammaglobulinemia for over 15 years. Immunodeficiency investigations showed a defective antibody response with a panhypogammaglobulinemia but normal cell-mediated immunity. Serum protein electrophoresis and detection of natural and acquired antibodies in the blood are the basic biological tests to run for a quick diagnosis. The main long term complication consists of the risk of neoplasia. The patient recovered a good clinical status after she was treated by IgG infusions every 2,5 weeks and antibiotics in case of superimposed infection.
D000293:Adolescent; D000361:Agammaglobulinemia / Q000175:diagnosis* / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D005759:Gastroenteritis / Q000209:etiology; D006801:Humans; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000209:etiology; D013997:Time Factors
Hypogammaglobulinémie commune d'expression variable. A propos d'une nouvelle observation.