[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives].
Study of the corticosteroid content in the adrenals and blood of rats under pantothenate deficiency has demonstrated a decrease in adrenocortical function. A single administration of pantothenate in a dose of 3.3 mg/kg reduced the influence of hypovitaminosis on the adrenals. The pantothenate derivatives (pantethine, 4'-phosphopantothenate and CoA in particular) injected to intact animals in a single dose equimolar to 3.3 mg/kg calcium pantothenate per kg bw had a marked steroidogenous effect.
D015062:11-Hydroxycorticosteroids / Q000032:analysis; D000302:Adrenal Cortex / Q000032:analysis / Q000187:drug effects / Q000503:physiopathology*; D000818:Animals; D003065:Coenzyme A / Q000494:pharmacology; D008297:Male; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000172:deficiency* / Q000494:pharmacology; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology
D015062:11-Hydroxycorticosteroids; D010205:Pantothenic Acid; D003065:Coenzyme A
Funktsional'naia aktivnost' kory nadpochechnikov pri nedostatochnosti pantotenata i vvedenii vitamina ili ego proizvodnykh.