[Submicroscopic changes in the capillary cells of an area of osteogenesis during body uptake of lead acetate].
Ultrastructurometry has revealed that daily entry of lead acetate in a dose of 50-100 mg/kg per body weight for 1-2.5 months increases chromatin condensation in nuclei, promotes swelling and myelin-like degeneration of the mitochondria, hyperplasia of the endoplasmic net, as well as appearance of the "enlightment" zones in the cytoplasm of endotheliocytes and perivascular cells of the capillaries from a metaphyseal zone of the rat femur. These changes are a consequent of the edema of cells and of the decrease in their biosynthetic activity.
D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D005269:Femur / Q000098:blood supply* / Q000187:drug effects / Q000648:ultrastructure; D007854:Lead / Q000032:analysis / Q000633:toxicity*; D008677:Metaphase / Q000187:drug effects; D008854:Microscopy, Electron; D009942:Organometallic Compounds; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013054:Spectrophotometry, Atomic; D013997:Time Factors
D009942:Organometallic Compounds; D007854:Lead; C008261:lead acetate
Submikroskopicheskie izmeneniia v kletkakh kapilliarov zony osteogeneza pri postuplenii v organizm atsetata svintsa.