title: Changes in histamine metabolism in the mouse hypothalamus induced by acute administration of ethanol.
abstract: The effect of acute ethanol administration on histamine (HA) dynamics was examined in the mouse hypothalamus. The steady-state level of HA did not change after intraperitoneal administration of ethanol (0.5-5 g/kg), whereas the level of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, increased when 3 and 5 g/kg of ethanol was given. Pargyline hydrochloride (80 mg/kg, i.p.) increased the level of t-MH by 72.2% 90 min after the treatment. Ethanol at any dose given did not significantly affect the t-MH level in the pargyline-pretreated mice. Decrease in the t-MH level induced by metoprine (10 mg/kg, i.p.), an inhibitor of HA-N-methyltransferase, was suppressed by ethanol (5 g/kg), thereby suggesting inhibition of the elimination of brain t-MH. Ethanol (5 g/kg) significantly delayed the depletion of HA induced by (S)-alpha-fluoromethylhistidine (50 mg/kg, i.v.), a specific inhibitor of histidine decarboxylase. Therefore, a large dose of ethanol apparently decreases HA turnover in the mouse hypothalamus.
mesh_terms: D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008761:Methylhistamines / Q000032:analysis / Q000378:metabolism; D008762:Methylhistidines / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010293:Pargyline / Q000494:pharmacology; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
chemical_list: D008761:Methylhistamines; D008762:Methylhistidines; C006308:metoprine; D000431:Ethanol; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D010293:Pargyline; C020404:tele-methylhistamine; D011739:Pyrimethamine