title: Major rectal complications following interstitial implantation of 125iodine for carcinoma of the prostate.
abstract: From April 1975 through April 1983, 152 patients were treated for localized adenocarcinoma of the prostate with interstitial implantation of 125iodine seeds. In each case bilateral pelvic lymph node dissection was performed at implantation. Five rectal complications developed: 2 rectal ulcers and 3 prostatic urethrorectal fistulas. Our method to treat these problems is presented together with our technique of reconstruction in patients with persistent fistulas despite fecal diversion. While urethrorectal fistulas represent potentially devastating complications of the 125iodine implantation procedure, reconstructive techniques can minimize and have reduced their long-term effects.
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D012002:Rectal Diseases / Q000209:etiology*; D012003:Rectal Fistula / Q000209:etiology*; D014456:Ulcer / Q000209:etiology; D014522:Urethral Diseases / Q000209:etiology*; D014548:Urinary Fistula / Q000209:etiology*
chemical_list: D007457:Iodine Radioisotopes