Prednisolone elimination in human saliva.
The elimination of prednisolone in saliva was studied following administration of intravenous doses of 16, 32, 48 and 64 mg to 7 healthy human subjects. While there was an approximate relationship between salivary and plasma concentrations of prednisolone a wide inter- and intraindividual variation in the ratio of the concentration in these two body fluids was observed. Salivary estimations of prednisolone concentration cannot replace plasma concentrations in biopharmaceutical studies.
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D013997:Time Factors
D011239:Prednisolone