[Adrenergic regulation of adenylate cyclase activity in the myocardium of rats of different ages].
The mechanism of regulation of adenylate cyclase activity has been studied in adult and old rats. The basal and fluoride-stimulated adenylate cyclase activity was found to remain unchanged, while the epinephrine-stimulated enzyme activity rised in myocardium of adult and old rats. In chemical denervation the basal and stimulated activity of adenylate cyclase increased irrespective of age, the basal and epinephrine-stimulated activity of the enzyme was significantly higher in old rats. The age-related differences in regulation of myocardial adenylate cyclase appear to be determined by changes in receptor-mediated properties of adenylate cyclase complex. This phenomenon is responsible for peculiarities of the humoral regulation of the heart functions during ageing.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000375:Aging; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012110:Reserpine; D012969:Sodium Fluoride / Q000494:pharmacology; D013563:Sympathectomy, Chemical
D011941:Receptors, Adrenergic; D012110:Reserpine; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D004837:Epinephrine
Adrenergicheskaia reguliatsiia aktivnosti adenilattsiklazy miokarda krys raznogo vozrasta.