title: Organophosphate-mediated inhibition of choline acetyltransferase activity in rat brain tissue.
abstract: Administration of the organophosphate compound soman in rats resulted in an inhibition of choline acetyltransferase activity in almost all brain regions examined. Enzyme activity was inhibited by 20-50% in various brain regions 30 min after soman injection (94-120 micrograms/kg). Enzyme activity in two regions decreased with time to a near zero level by 3 h after injection.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000037:antagonists & inhibitors*; D004027:Diencephalon / Q000201:enzymology; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000494:pharmacology*; D013687:Telencephalon / Q000201:enzymology; D014018:Tissue Distribution
chemical_list: D012999:Soman; D002795:Choline O-Acetyltransferase