Clinically derived dose effect relationship for hyperthermia given in combination with low dose radiotherapy.
A group of 36 patients, treated on 44 fields with fractionated treatments of local high-frequency induced hyperthermia and radiotherapy to the low total dose of 14-25 Gy, was retrospectively evaluated for differences between responders (i.e., complete and partial responders) and non-responders. A response rate of 86% was achieved, comprising 14% (6/44) complete and 73% (32/44) partial response. There was an indication that the probability of complete response is greater in smaller tumours. The tumour temperatures achieved were higher in the responders than in the non-responders. Logistic analysis was performed on the mean temperature achieved. This temperature parameter yielded a significant positive dose-effect relationship with regard to therapeutic effect, from which a 50% effective dose of 38.8 degrees C was calculated. The data indicate that to obtain the maximum therapeutic effect, i.e., greater than 95% response rate, tumour temperatures above 42.5 degrees C need to be achieved.
D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*