Decreased parvalbumin contents in skeletal muscles of C57BL/6J(dy2J/dy2J) dystrophic mice.
Parvalbumin content is decreased by 40% in hindlimb muscles of adult (3.5 months) dystrophic mice when compared to normal mice of the same age. The concentration of parvalbumin in the dystrophic muscles resembles that of immature muscles of 4-week-old normal mice. The reduction may contribute to an elevation of sarcoplasmic free CA2+, which could stimulate various Ca2+-dependent processes related to the disease.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D009124:Muscle Proteins / Q000032:analysis*; D009132:Muscles / Q000032:analysis*; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D010320:Parvalbumins / Q000032:analysis* / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D009124:Muscle Proteins; D010320:Parvalbumins; D002118:Calcium