Hypolipidemic effects of dietary 7-oxo-24,25-dihydrolanosterol.
7-Oxo-24,25-dihydrolanosterol (7-oxo-DHL), an inhibitor of cholesterol biosynthesis from lanosterol in vitro, lowered the serum total-cholesterol and triglyceride at a level of 0.1% in a diet on male Wistar rats. This effect was slightly lower than that of clofibrate (CF) which was examined as a reference. Further, the reduction in serum total-cholesterol levels were associated with a slight reduction in the levels of high density lipoprotein (HDL) cholesterol, resulting in a decrease in the atherogenic index. The rate of decrease of liver total-cholesterol by 7-oxo-DHL was higher than that of CF soon after taking off the diet. Although CF produced a marked increase of liver size, no significant increase was observed in the rats fed with 7-oxo-DHL. The effects of 7-oxo-DHL in the rats fed with 3% cholesterol in a diet were examined and compared with that of control. These results strongly suggest that 7-oxo-DHL is considerably hypolipidemic in rats.
D000818:Animals; D002791:Cholesterol, Dietary / Q000494:pharmacology; D002994:Clofibrate / Q000494:pharmacology; D004036:Diet, Atherogenic; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D008055:Lipids; D007810:Lanosterol; C047418:7-oxo-24,25-dihydrolanosterol; D002994:Clofibrate