[Some peculiarities of regulation of the adrenal pyruvate de- hydrogenase complex by acetyl-coenzyme A].
Acetyl-CoA increased incorporation of 32P from [gamma-32P]ATP into the adrenal pyruvate dehydrogenase complex (PDC), but did not raise the rate of inactivation of the complex. This may be explained by the stimulation of phosphorylation of the centers which are not responsible directly for the PDC activity. At the same time the PDC phosphorylated in the presence of acetyl-CoA was reactivated slower by specific phosphatase.
D000105:Acetyl Coenzyme A / Q000494:pharmacology*; D000311:Adrenal Glands / Q000201:enzymology*; D010766:Phosphorylation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*
D011768:Pyruvate Dehydrogenase Complex; D000105:Acetyl Coenzyme A
Osobennosti reguliatsii nadpochechnikovogo piruvatdegidrogenaznogo kompleksa atsetil-kofermentom A.