Are there valid reasons for using anti-muscarinic drugs in the management of renal colic?
Experiments have been carried out with isolated ring preparations of human ureter. The tissue displayed spontaneous activity and contracted when exposed to barium chloride (0.5-4 mM) but no responses were obtained with carbachol (0.1 micromolar-0.1 mM). This raises questions about the value of treating ureteric colic with anti-muscarinic drugs.
D001464:Barium / Q000494:pharmacology*; D017609:Barium Compounds; D002217:Carbachol / Q000494:pharmacology*; D002712:Chlorides; D003085:Colic / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000188:drug therapy; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000627:therapeutic use; D014513:Ureter / Q000187:drug effects*
D017609:Barium Compounds; D002712:Chlorides; D010276:Parasympatholytics; C024986:barium chloride; D001464:Barium; D002217:Carbachol