title: Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons.
abstract: The effects of 15 minute periods of coronary artery occlusion on plasma creatine kinase (CK) and CK-MB isoenzyme activity, regional myocardial function and subsequent myocardial necrosis were studied in six conscious baboons 2 to 3 weeks after recovery from instrumentation. Mid left anterior descending coronary artery occlusion induced complete loss of systolic wall thickening (ultrasound transit time technique) and decreases in epicardial (-93%) and endocardial (-96%) blood flows (microsphere technique). Reperfusion after 15 minutes resulted in complete recovery of regional function 24 hours later. Serial plasma enzyme activity revealed a significant increase in total CK from 71 +/- 11 to 976 +/- 158 U/liter and in CK-MB from levels that were too low to measure to 21.4 +/- 2.9 U/liter. At autopsy, neither gross pathologic evidence (triphenyltetrazolium chloride staining technique) nor histologic evidence of myocardial necrosis was observed. Thus, in the conscious baboon short episodes of myocardial ischemia are associated with a significant appearance of CK and CK-MB in the blood in the absence of cellular necrosis.
mesh_terms: D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood*; D007527:Isoenzymes; D008297:Male; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D010215:Papio / Q000097:blood; D016276:Ventricular Function
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase