Methods for determination of ionophore-type antibiotic residues in animal tissues.
Methods for the analysis of polyether antibiotics in animal tissues and fluids are described. For monensin and nigericin, only methods based on bioautography are available. For lasalocid, in addition to TLC bioautography for quantitation in chicken skin and fat, LC methods based on fluorescence detection have been developed for quantitation in animal blood, milk, liver, skin, and fat. In addition, a confirmatory method for lasalocid is described; this is based on purification by LC followed by silylation and pyrolysis gas chromatography-positive chemical ionization mass spectrometry.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis*; D002417:Cattle; D002645:Chickens; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer; D008401:Gas Chromatography-Mass Spectrometry; D007476:Ionophores / Q000032:analysis*; D007832:Lasalocid / Q000032:analysis; D008460:Meat / Q000032:analysis; D008892:Milk / Q000032:analysis; D008970:Molecular Weight; D008985:Monensin / Q000032:analysis; D011714:Pyrans / Q000032:analysis; D012756:Sheep; D014481:United States; D000095662:Polyether Polyketides
D000900:Anti-Bacterial Agents; D007476:Ionophores; D007832:Lasalocid; D008985:Monensin; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides