Structure of the chromosomal gene for human serum prealbumin.
The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3'-flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found in the 5'-flanking region and introns.
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D011228:Prealbumin / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D011228:Prealbumin