Renal nerves are not necessary for onset or maintenance of DOC-salt hypertension in rats.
The effect of renal denervation on the onset and maintenance of mineralocorticoid-salt [deoxycorticosterone (DOC)-salt] hypertension was determined. A unilateral right nephrectomy was performed on all rats. Rats were divided into renal-denervated and sham-operated groups. All rats received 10 mg/wk of DOC pivalate and 0.9% saline to drink ad libitum. Renal denervation was repeated at 3-wk intervals to prevent renal nerve regeneration. Renal denervation had no effect on the onset or maintenance of DOC-salt hypertension. Hypertension developed over the same time course in both the renal-denervated and sham-operated rats regardless of the time frame of unilateral nephrectomy and renal denervation. Tail-cuff pressure measurements reached plateau levels of 187 +/- 5.7 mmHg in sham-operated and 183 +/- 4.6 mmHg in renal-denervated rats after 4 wk of DOC-salt administration. Mean arterial pressure averaged 197 +/- 10.3 mmHg in sham-operated and 200 +/- 7.9 mmHg in renal-denervated rats after 8 wk of treatment. Intact renal nerves are not necessary for the development or maintenance of DOC-salt hypertension in rats.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003714:Denervation; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced*; D007668:Kidney / Q000294:innervation* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology*; D013623:Tail / Q000098:blood supply
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009638:Norepinephrine