[Changes in the transcription capacity of the chromatin of nerve and liver cells exposed to morphine and opioids].
Morphine stimulates in vitro 3H-UTP incorporation into the nuclei of neurons of the superior cervical ganglion and into the hepatocyte nuclei of some rodents. This effect is dose-dependent and partially inhibited by naloxone. A synthetic analog of enkephalins, D-Ala2-Gly-ol5-enkephalin (DAGO), and beta-endorphin stimulate the incorporation of RNA precursors into pre-rRNA. Possible mechanisms of morphine action are discussed.
D000818:Animals; D001345:Autoradiography; D002843:Chromatin / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009562:Nissl Bodies / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D014158:Transcription, Genetic / Q000187:drug effects*; D014544:Uridine Triphosphate / Q000378:metabolism
D002843:Chromatin; D004723:Endorphins; D009270:Naloxone; D009020:Morphine; D014544:Uridine Triphosphate
Izmenenie transkriptsionnoĭ sposobnosti khromatina nervnykh i pechenochnykh kletok pri deĭstvii na nikh morfina i nekotorykh opioidov.