Standardization of inactivated H5N2 influenza vaccine and efficacy against lethal A/Chicken/Pennsylvania/1370/83 infection.
The hemagglutinin concentration of beta-propiolactone-inactivated influenza vaccine containing A/Duck/N.Y./189/82 (H5N2) virus was measured by single-radial-immunodiffusion (SRD) test. After administration of vaccine to chickens in Freund's complete adjuvant, vaccine efficacy was assessed by challenge with lethal A/Chicken/Penn./1370/83 (H5N2) virus. SRD potency values correlated with post-vaccination antibody levels and protection against infection.
D000818:Animals; D002645:Chickens; D006389:Hemagglutinins, Viral / Q000276:immunology; D053125:Influenza A Virus, H5N2 Subtype; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000592:standards* / Q000627:therapeutic use; D005585:Influenza in Birds / Q000517:prevention & control*; D009439:Neuraminidase / Q000276:immunology; D011201:Poultry Diseases / Q000517:prevention & control; D014611:Vaccination
D006389:Hemagglutinins, Viral; D007252:Influenza Vaccines; D009439:Neuraminidase