Induction of sister-chromatid exchanges in Chinese hamster ovary cells by the biotic ketoaldehyde methylglyoxal.
The number of sister-chromatid exchanges (SCEs) per metaphase was determined in Chinese hamster ovary cells after 16 h exposure to methylglyoxal (MG) concentrations ranging from 0.1 to 0.75 mM. MG produced an increase of SCE frequency that proved to be dose-dependent, and to reach a maximum of 2 X baseline at the highest nontoxic concentration (0.5 mM).
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D010053:Ovary; D011765:Pyruvaldehyde / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000447:Aldehydes; D011765:Pyruvaldehyde