[Electron microscopic study of the effect of the antioxidant action of alpha-tocopherol].
Electron microscopy was used to study antioxidant action of alpha-tocopherol by examining gastric mucosa biopsies from schizophrenic patients kept on a prolonged fasting diet. Intramuscular injection of 100 mg alpha-tocopherol a day over 20 days did not influence fatty infiltration of the parietal cells. At the same time alpha-tocopherol promoted active oxidation of infiltrative lipids and excretion of oxidation products from the cells. The preparation exerted a marked protective effect on the maintenance of the integrity of membrane complexes of gastric mucosa cells, prevented the development of fatty degeneration of granulocytes characteristic of a prolonged fasting diet.
D000975:Antioxidants; D004341:Drug Evaluation; D005215:Fasting; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D010295:Parietal Cells, Gastric / Q000378:metabolism / Q000648:ultrastructure; D012559:Schizophrenia / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D013997:Time Factors; D014810:Vitamin E / Q000378:metabolism / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000378:metabolism / Q000473:pathology
D000975:Antioxidants; D014810:Vitamin E
Elektronno-mikroskopicheskoe izuchenie éffekta antioksidantnogo deĭstviia al'fa-tokoferola.