Genome multiplication in cardiomyocytes of fast- and slow-growing mice.
The number of myocytes and the percentage of cells with a high degree of ploidy increased in the heart ventricles of fast-growing mice compared with slow-growing ones. The mean incidence of octa- and hexadecaploid (by summary DNA content) myocytes was 7% in the slow-growing and 23% in the fast-growing, weaned mice. In these groups, the total myocyte number varied by 20%. There were 43% more myocyte genomes in the heart ventricles of the fast-growing mice than in those of the slow-growing mice. The same differences in cell number and ploidy persist in 90-day-old mice in spite of feeding ad libitum after weaning.
D000375:Aging; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development; D001835:Body Weight; D005260:Female; D006321:Heart / Q000254:growth & development*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009124:Muscle Proteins / Q000032:analysis; D009206:Myocardium / Q000166:cytology*; D009929:Organ Size; D011003:Ploidies; D011123:Polyploidy; D013997:Time Factors
D009124:Muscle Proteins