Cyclophosphamide-induced remission in Weber-Christian panniculitis.
A patient with Weber-Christian panniculitis is described in this report in which treatment with prednisone and hydroxychloroquine caused no improvement of the disease, and even led to a worsening of the symptoms. In contrast, administration of oral cyclophosphamide led to a rapid remission of the disease. As Weber-Christian disease has no known aetiology and no specific treatment has been established, the successful therapy with the cytostatic drug cyclophosphamide may shed light on the pathogenesis of Weber-Christian panniculitis.
D000328:Adult; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008297:Male; D010201:Panniculitis, Nodular Nonsuppurative / Q000188:drug therapy* / Q000209:etiology; D011241:Prednisone / Q000627:therapeutic use
D006886:Hydroxychloroquine; D003520:Cyclophosphamide; D011241:Prednisone