Effects of 2-chloroadenosine on amygdaloid and hippocampal kindled seizures.
The effects of 2-chloroadenosine (2-CLA), a metabolically stable analogue of adenosine, on amygdaloid and hippocampal kindled seizures were examined in rats. Intraperitoneal injections of 2-CLA, 1.0 mg/kg, did not modify the evolution of either amygdaloid or hippocampal kindled seizures. 2-CLA in the dose of 3.0 mg/kg shortened the duration of both behavioral and electrographic convulsive manifestations while the dose of 5.0 mg/kg completely blocked the evolution of the kindled seizures. The results indicate that purinergic mechanisms are involved in the maintenance and modulation of the seizure threshold within the limbic system.
D015762:2-Chloroadenosine; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
D015762:2-Chloroadenosine; D000241:Adenosine