Mucociliary transport in the human nose. Effect of topical glucocorticoid treatment.
The effect of topical budesonide on the human mucociliary transport in the nose was investigated utilizing the saccharin-dye test in 10 healthy volunteers. Measurements were made before treatment, after a single dose and after one week continuous treatment with either placebo or active substance. The design of the study was double blind, randomized and cross-over. A single dose of placebo or budesonide did not alter the mucociliary transport as compared to pretreatment values. A trend towards decrease of mucociliary transport was noted after one week treatment with the active drug, a trend that reached statistical significance in the comparison between the 1 h value and the 1 week value.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D019819:Budesonide; D002923:Cilia / Q000187:drug effects; D004396:Coloring Agents; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects; D009666:Nose / Q000187:drug effects*; D011282:Pregnenediones / Q000008:administration & dosage / Q000494:pharmacology*; D012439:Saccharin; D013997:Time Factors
D004396:Coloring Agents; D011282:Pregnenediones; D019819:Budesonide; D012439:Saccharin