Dominantly inherited ureteropelvic junction obstruction.
We report on siblings from two families with unilateral ureteropelvic junction obstruction. HLA studies were undertaken and found to be a useful marker between affected members. We believe that incomplete penetrance with variable expression is the most probable mode of transmission of this disorder.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005786:Gene Expression Regulation; D005787:Gene Frequency; D005799:Genes, Dominant; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D006869:Hydronephrosis / Q000235:genetics / Q000473:pathology; D007682:Kidney Pelvis / Q000473:pathology; D008297:Male; D010375:Pedigree; D014517:Ureteral Obstruction / Q000235:genetics* / Q000473:pathology
D006680:HLA Antigens