Interaction of UV and N-methyl-N'-nitro-N-nitrosoguanidine: cytotoxicity and mutagenicity in V79 cells.
Killing and mutation by UV in the MNNG-exposed population of V79 cells, as well as by MNNG in the UV-irradiated population of these cells have been studied. It was observed that pretreatment with MNNG increased the killing and mutation by UV, whereas, pretreatment with UV had no effect upon killing and mutation by MNNG. The increase in sensitivity to UV due to pretreatment with MNNG was lost if UV exposure was delayed for 24 h after MNNG treatment.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects*; D008168:Lung; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009154:Mutation; D014466:Ultraviolet Rays
D000477:Alkylating Agents; D008769:Methylnitronitrosoguanidine