Gentamicin serum half-life: a comparison between pregnant and non-pregnant women.
The serum half-life of gentamicin following an intravenous dose was compared between 19 pregnant women (28-34 weeks of pregnancy) with premature rupture of the membranes and 17 non-pregnant women with pelvic inflammatory disease, the groups being age and weight matched. A significant reduction of gentamicin half-life was found in the pregnant group.
D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D005839:Gentamicins / Q000097:blood*; D006207:Half-Life; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000097:blood; D011247:Pregnancy
D005839:Gentamicins; D003404:Creatinine