Pathological observations in experimental candida infection of sensitized guinea pigs.
Guinea pigs immunized intramuscularly with heat-killed or viable Candida albicans were infected intracutaneously with C. albicans. Animals with negative delayed hypersensitivity against C. albicans antigen showed similar lesions with non-immunized controls. Delayed hypersensitivity-positive guinea pigs, which were detected in the animals immunized with heat-killed C. albicans in CFA and IFA, demonstrated a delay of the resolution of the inflammatory tissue reaction and, in the animals immunized with C. albicans in CFA, developed a granuloma. These results suggest that both humoral and cell-mediated immunities do not play a significant role for protection against candidiasis and at a late stage of infection, cell-mediated immunity may play a secondary role of the enhancement of resistance to candida infection associated with granuloma formation.
D000818:Animals; D002179:Candidiasis, Cutaneous / Q000276:immunology / Q000473:pathology*; D005260:Female; D006168:Guinea Pigs; D007109:Immunity; D007114:Immunization; D008262:Macrophage Activation; D008297:Male