[Biospecific sorbent for removal of proteinases from biological fluids].
Sorbents for removal of proteases from biological fluids were synthesized via immobilization of a specific protease inhibitor-ovomucoid from whites of duck eggs--in the bulk of polymeric hydrogel. The sorbents were shown to exhibit high capacity and selectivity in the removal of proteases from the model protein-containing solutions, blood plasma and blood. The sorbents did not affect the blood cells as well as the blood-clotting system. The sorbents were demonstrated to be effective in the removal of proteases from canine blood in acute pancreatitis.
D000208:Acute Disease; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D002417:Cattle; D004285:Dogs; D004372:Ducks; D004527:Egg Proteins / Q000138:chemical synthesis / Q000494:pharmacology; D004800:Enzymes, Immobilized / Q000138:chemical synthesis / Q000494:pharmacology; D006464:Hemoperfusion; D008024:Ligands; D010059:Ovomucin / Q000138:chemical synthesis / Q000494:pharmacology; D010195:Pancreatitis / Q000097:blood / Q000628:therapy; D011480:Protease Inhibitors / Q000097:blood*; D011817:Rabbits
D004527:Egg Proteins; D004800:Enzymes, Immobilized; D008024:Ligands; D011480:Protease Inhibitors; D010059:Ovomucin
Biospetsificheskiĭ sorbent dlia udaleniia proteinaz iz biologicheskikh zhidkosteĭ.