Familial ciliary dyskinesis: a cause of infertility without respiratory disease.
Two brothers were found to have primary infertility and nonmotile sperm secondary to ultrastructural defects, which included absent central doublets and peripheral microtubular translocation. No personal or family history of sinobronchial disease was obtained. Although sporadic cases of this type of ciliary dyskinesis have been reported, our patients constitute the first known occurrence of familial association.
D000328:Adult; D002925:Ciliary Motility Disorders / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities