Globin chain synthesis in a case of acquired aplastic anaemia before and after remission induced by bolus methylprednisolone treatment.
Globin chain synthesis was performed with the peripheral blood of a 10-year-old girl, who had acquired aplastic anaemia, at the time of bolus methylprednisolone administration and during recovery. There was no indication of an increase in gamma chain synthesis despite elevation of total foetal haemoglobin.
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D002648:Child; D005260:Female; D005914:Globins / Q000096:biosynthesis*; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008775:Methylprednisolone / Q000627:therapeutic use*; D013997:Time Factors
D007306:Insecticides; D005914:Globins; D008775:Methylprednisolone