Anti-inflammatory effects of ketoprofen in rabbit corneal epithelial wound model.
Ocular anti-inflammatory effects of ketoprofen were assessed and compared with indomethacin in the rabbit corneal epithelial wound model. Intraperitoneally (5 mg kg-1 and 50 mg kg-1) and topically (0.01%) administered ketoprofen and topical indomethacin (0.5%) prevented the release of polymorphonuclear leukocytes (PMNs) into the tear fluid of rabbits following partial de-epithelialization. However, 0.001% ketoprofen applied topically potentiated the PMN response. Topical ketoprofen at all doses tested equally inhibited prostaglandin (PG) synthesis in both conjunctiva and iris-ciliary body. In contrast, indomethacin was more effective in inhibiting PG synthesis in conjunctiva than in the iris-ciliary body. In addition, anti-inflammatory doses of ketoprofen did not interfere with wound healing after complete corneal de-epithelialization in rabbits.
D000818:Animals; D002924:Ciliary Body / Q000187:drug effects / Q000378:metabolism; D003228:Conjunctiva / Q000187:drug effects / Q000378:metabolism; D065306:Corneal Injuries; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D007498:Iris / Q000187:drug effects / Q000378:metabolism; D007660:Ketoprofen / Q000494:pharmacology*; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010666:Phenylpropionates / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis; D011817:Rabbits; D013666:Tears / Q000166:cytology; D014945:Wound Healing / Q000187:drug effects*
D010666:Phenylpropionates; D011458:Prostaglandins E; D007660:Ketoprofen; D007213:Indomethacin