Endotoxic effects of peptidoglycan.
Peptidoglycans (PG) are cell wall fragments of gram-positive bacteria. The effect of PG on blood pressure, circulating leukocytes, and platelets was studied in a rat model. PG was able to decrease blood pressure and to induce leukopenia and thrombocytopenia. In vitro PG affected leukocyte function and was able to activate the contact activating system.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010457:Peptidoglycan / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D010457:Peptidoglycan