Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II): a common genotype linked to oncogenes?
We hypothesize that: hereditary nonpolyposis colorectal cancer (HNPCC) accounts for a significant proportion of the colon cancer burden; the premalignant colonic mucosa in HNPCC patients may be comparable in many respects to the premalignant polyps in its hereditary multiple adenomatous polyposis counterpart; and finally, study of HNPCC colonic mucosa may harbor important clues for elucidation of the multistep process of carcinogenesis, including relationships between activated oncogenes, genetics, and environmental perturbations.
D000236:Adenoma / Q000235:genetics; D003110:Colonic Neoplasms / Q000145:classification / Q000235:genetics*; D003111:Colonic Polyps / Q000235:genetics; D005838:Genotype; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics; D009857:Oncogenes; D012004:Rectal Neoplasms / Q000145:classification / Q000235:genetics*; D013577:Syndrome