title: Colorectal cancer in familial polyposis coli and ulcerative colitis.
abstract: The records of all patients with familial polyposis coli and ulcerative colitis operated at The Mount Sinai Hospital were reviewed to determine the proportion of patients with cancer at the time of colon resection. Sixty-nine patients with familial polyposis coli undergoing operation between 1947 and 1983 were identified and 25 (36 percent) were found to have cancer. In the group with ulcerative colitis, 548 patients had surgical treatment between 1957 and 1983 and 65 (12 percent) had colonic cancer. There was a significant decrease in the proportion of patients with familial polyposis coli having cancer at the time of colon resection from 50 percent before 1968 to 20 percent since 1978. This change in cancer incidence was found to correlate with a decrease in the mean age at operation from 40 to 25 years. In the group with ulcerative colitis, the mean age at operation has remained essentially unchanged at 36 years. The proportion of patients with ulcerative colitis having cancer at the time of colon resection has remained constant throughout this study. Progression to carcinoma is still a significant concern in both familial polyposis coli and ulcerative colitis. Although removal of the colon and rectum prevents cancer development, patient selection and timing of the operation remain a difficult problem.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery*; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000601:surgery; D003111:Colonic Polyps / Q000235:genetics / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011230:Precancerous Conditions / Q000601:surgery*; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies