Clinicopathologic studies on neuro-Behçet's disease.
Nine cases of neuro-Behcet's disease were investigated clinicopathologically. Pathological pictures of the central nervous system were characterized as follows: the site of predilection was the brain stem, followed by the spinal cord, cerebrum and cerebellum. The pathognomonic changes were recurrent inflammations around small vessels, causing a softening of the tissue. Lesions were composed of a perivascular infiltration of lymphocytes, histiocytes and microglias and, moreover, diapedesis, degenerated nerve cells and oligodendroglias, glial nodule, breakdown of myelin and axon, fatty granule cells and glio-mesenchymal proliferation were present occasionally. Electron microscopic studies on the neurons revealed no evidence of viral particles except for some accumulations of electron dense bodies.
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications* / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology