A genetic analysis of stereotypy in the mouse: dopaminergic plasticity following chronic stress.
After repeated stressful experiences, DBA/2 (DBA) mice showed an increase in apomorphine-induced climbing while C57BL/6 (C57) mice showed a clear-cut decrease of this behavior. Genetic analysis involving F1 and F2 hybrids and the backcross populations (F1 X C57; F1 X DBA) indicated complete dominance of the C57 genotype and a significant genotype X environment interaction. These findings are discussed in terms of dopaminergic plasticity and of the heuristic value of this animal model in relation to disturbed behaviors triggered by stressful experiences.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003433:Crosses, Genetic; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005838:Genotype; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics*; D009473:Neuronal Plasticity / Q000187:drug effects*; D012149:Restraint, Physical; D013239:Stereotyped Behavior / Q000502:physiology*; D013315:Stress, Psychological / Q000235:genetics
D001058:Apomorphine; D004298:Dopamine