[Mechanism of development of erythrocytosis in spontaneous arterial hypertension in rats].
Rats with spontaneous hypertension versus normotensive rats showed the development of erythrocytosis, an intensification of the erythropoietic properties of the blood plasma and an increase of the 2,3-DPG concentration in the red blood cells. An enhanced production of erythropoietin, a humoral stimulator of erythropoiesis, seems to be one of the causes of the erythrocytosis development in spontaneously hypertensive rats. An increase in the 2,3-DPG concentration in the erythrocytes is an important physiological mechanism ensuring the appropriate oxygen supply to tissues.
D019794:2,3-Diphosphoglycerate; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood; D004906:Erythrocyte Count; D004920:Erythropoiesis; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006973:Hypertension / Q000097:blood*; D008297:Male; D011086:Polycythemia / Q000209:etiology*; D051381:Rats; D011918:Rats, Inbred SHR
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate
O mekhanizme razvitiia eritrotsitoza pri spontannoĭ arterial'noĭ gipertenzii u krys.