4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist.
4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone (1c) (SK&F 101468) is a potent and selective prejunctional dopamine receptor agonist. It caused a dose-related inhibition of the constrictor response to electrical stimulation in the isolated perfused rabbit ear artery (EC50 = 100 nM), and this response was antagonized by (S)-sulpiride (KB = 7 nM). Compound 1c did not stimulate or block dopamine-sensitive adenylate cyclase and did not produce stimulation of the central nervous system in rats. It was prepared from (2-methyl-3-nitrophenyl)acetic acid in a multistep sequence based on the Reissert indole synthesis.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D011817:Rabbits; D011954:Receptors, Dopamine / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects
D007211:Indoles; D011954:Receptors, Dopamine; C046649:ropinirole