Effect of prior treatment with thioglycolate on the incubation period of intraperitoneally injected scrapie.
Injection of mice with thioglycolate 5 days prior to intraperitoneal injection of scrapie brain homogenate led to a statistically significant increase in scrapie incubation periods. This was seen with two different scrapie strains (ME7 and 139A), in different mouse strains (C57BL/6J and Compton White), and at several dilutions of the scrapie inoculum.
D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D010586:Phagocytes / Q000187:drug effects; D012608:Scrapie / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013045:Species Specificity; D013864:Thioglycolates / Q000494:pharmacology*; D013997:Time Factors
D013864:Thioglycolates