title: Hypoxia potentiates, oxygen attenuates deflation-induced reflex tracheal constriction.
abstract: The reflex tracheomotor responses of in situ isolated segments of the extrathoracic trachea of anesthetized, paralyzed, and ventilated dogs were monitored. Reflex tracheal constriction was evoked by passive lung deflation. The purpose of this study was to determine whether the prevailing state of oxygenation altered the magnitude of this reflex. Compared with the magnitude of the response during normoxia [arterial O2 tension (PaO2) = 78 Torr], that during hypoxia (PaO2 = 44 Torr) was nearly threefold larger while that during hyperoxia (PaO2 greater than 250 Torr) was about 50% smaller. The isocapnic changes in oxygenation by themselves usually had no effect on tracheomotor tone. The deflation-induced reflex tracheal constriction was eliminated by complete denervation of the tracheal segment but usually only diminished by partial denervation. Bilateral vagotomies or bilateral carotid body denervation also usually decreased the magnitude of the reflex. It appears that the magnitude of this reflex is dependent on the prevailing state of oxygenation and that a pulmonary stretch receptor-carotid body chemoreceptor interaction accounts for the exaggerated reflex tracheal constriction during hypoxia and the attenuated response during hyperoxia.
mesh_terms: D000403:Airway Resistance; D000818:Animals; D002344:Carotid Body / Q000502:physiology; D003714:Denervation; D004285:Dogs; D005260:Female; D000860:Hypoxia / Q000503:physiopathology*; D007823:Laryngeal Nerves / Q000502:physiology; D008176:Lung Volume Measurements; D008297:Male; D009119:Muscle Contraction; D010100:Oxygen / Q000494:pharmacology; D014132:Trachea / Q000503:physiopathology*
chemical_list: D010100:Oxygen