Contraception in male monkeys by intra-vas deferens injection of a pH lowering polymer.
A new male method of contraception by injecting a polymer, styrene-maleic anhydride (SMA), into the lumen of the vas deferens has been studied on rhesus monkeys. The polymer has the dual feature that it can occlude the vas deferens lumen and also it can inhibit the fertilising ability of spermatozoa by virtue of the pH lowering effect. Matings with females were carried out when the lumen was completely occluded giving azoospermia as well as with partial block and spermatozoa present in the semen. All matings were infertile. Data up to one year is presented. All indications are that the contraceptive effect will last for a considerably long period.
D000818:Animals; D003250:Constriction; D003267:Contraception / Q000379:methods*; D003272:Contraceptive Agents, Male / Q000008:administration & dosage*; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D008253:Macaca mulatta; D008297:Male; D008299:Maleic Anhydrides / Q000008:administration & dosage*; D009845:Oligospermia / Q000209:etiology; D011137:Polystyrenes / Q000008:administration & dosage*; D013094:Spermatozoa / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects*
D003272:Contraceptive Agents, Male; D005663:Furans; D008299:Maleic Anhydrides; D011137:Polystyrenes; C025704:Styromal