The effects of lead ion on immune function of rabbit alveolar macrophages: quantitation of immune phagocytosis and rosette formation by 51Cr in vitro.
Experiments by a 51Cr-labeling technique were performed to investigate the effects of lead (Pb2+) on immune phagocytosis and Fc-rosette formation of rabbit pulmonary alveolar macrophages (PAMs). Evidence is presented that Pb2+ at concentrations of 10(-3) and 10(-4)M could inhibit these functions of PAMs. The degree of inhibition corresponded to the concentration of this heavy metal ion in vitro.
D000818:Animals; D002452:Cell Count; D002860:Chromium Radioisotopes; D005260:Female; D007854:Lead / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D010587:Phagocytosis / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000276:immunology; D011817:Rabbits; D012397:Rosette Formation
D002860:Chromium Radioisotopes; D007854:Lead