Gastrointestinal absorption of Np in rats.
The effect of Np mass and the acidity of the administered Np solutions as well as the age, sex and nutritional status of the animals injected or gavaged with 239Np or 237Np were determined. The latter factor proved to be dominant for absorption of Np from the gut. Thus in fasting weanling and young adult male rats, the absorption of 239Np was sixfold higher (0.18% and 0.12%, respectively) than in fed ones (0.03% and 0.02%, respectively). Absorption by fasted adult females was 0.05% of the administered 239Np, about half of that of adult males. Raising the Np-mass gavaged to fasted female rats to 1 and 10 mg 237Np/kg resulted in an absorption of 0.23% and 0.26%, respectively. Thus, an increased absorption of Np in adult rats seems to be expected only if a large mass is ingested. No dependence of the absorption of Np on nitric acid concentration was found. The data obtained after oral administration of 238Pu and 239Np to adult rats suggest that the f1 factor recommended by the ICRP for fractional absorption of soluble Np compounds from the gut should be decreased, whereas the f1 factor for soluble Pu compounds should be raised.
D000818:Animals; D005215:Fasting; D005260:Female; D006863:Hydrogen-Ion Concentration; D007267:Injections; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D009405:Neptunium / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013270:Stomach; D014018:Tissue Distribution
D009405:Neptunium