Cerebral blood flow, metabolic rate, and cross-brain oxygen consumption in brain injury.
In six deeply comatose children, the relationships of intracranial pressure, cerebral perfusion pressure, cerebral blood flow, cross-brain oxygen consumption, and metabolic rate to outcome were studied sequentially during therapy. Intracranial pressure, cross-brain oxygen consumption, and metabolic rate values were significantly different in the three children who survived compared with those in the three who died. The differences in cross-brain oxygen consumption and metabolic rate occurred in the presence of clinically acceptable values for intracranial and cerebral perfusion pressures. Cross-brain oxygen consumption and metabolic rate may be important indicators of degree of neuronal injury, and of outcome.
D000293:Adolescent; D001794:Blood Pressure; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism / Q000401:mortality / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D004332:Drowning; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure; D010101:Oxygen Consumption; D011379:Prognosis