Pressure in the treatment of spinal cord decompression sickness.
Previous work had shown that a Po2 of about 2.0 bar was the optimal Po2 for the treatment of spinal cord decompression sickness (DCS). With 20 anesthetized dogs the hypothesis was tested that pressures in excess of a threshold, taken as 3 bar, did not enhance recovery of spinal cord DCS. Dogs were subjected to a 15-min air dive at 10 bar (300 ft) and decompressed over 5.5 min. At the surface, spinal cord evoked potentials (SEP) were observed for changes indicating DCS. Fifteen minutes after DCS was first detected the dogs were recompressed to 3, 5, 7, or 2.8 bar breathing 66, 40, 29, or 100% oxygen which gave a Po2 of 2.0 bar except in the 2.8 bar group. The recovery of the SEP over 2 h was observed. Group mean recoveries at 67, 62, 29, and 42% were not significantly different after 120 min. As the hypothesis was supported, a tentative proposal for changing current therapy was made.
D000818:Animals; D001274:Atmospheric Pressure; D001794:Blood Pressure; D002540:Cerebral Cortex / Q000503:physiopathology; D003665:Decompression Sickness / Q000503:physiopathology / Q000628:therapy*; D004242:Diving; D004285:Dogs; D004569:Electroencephalography; D005073:Evoked Potentials, Somatosensory; D006931:Hyperbaric Oxygenation; D007427:Intracranial Pressure; D008297:Male; D009433:Neural Inhibition; D010543:Peroneal Nerve / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology; D013118:Spinal Cord Diseases / Q000503:physiopathology / Q000628:therapy*