Severe aplastic anaemia following the use of hair dye: report of two cases and review of literature.
We describe two female patients aged 31 and 62 y who developed severe aplastic anaemia following the use of hair dye containing para-toluenediamine. One received a bone marrow transplant but died after developing graft versus host disease and severe opportunistic infection. The second responded to treatment with methylprednisolone, oxymetholone and antithymocyte globulin and 3 y later she has a normal blood count apart from mild thrombocytopenia. In this paper we also review previously described case reports of aplastic anaemia apparently associated with the use of hair dye.
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D005260:Female; D006202:Hair Dyes / Q000009:adverse effects*; D006203:Hair Preparations / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010655:Phenylenediamines / Q000009:adverse effects*
D006202:Hair Dyes; D006203:Hair Preparations; D010655:Phenylenediamines; C007303:2,5-diaminotoluene