Familial granulomatous arthritis, iritis, and rash.
Eleven family members over four generations have had granulomatous disease of the skin, eyes, and joints. Ten have had arthritis; two had skin, eye, and joint involvement; one had skin and joint disease, and one had iritis only. The disease is transmitted as an autosomal dominant trait and is not associated with HLA-B27. The disease resembles sarcoidosis in some ways but not in others, and is probably a new syndrome. The major long-term problems are iritis and joint contractures.
D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000235:genetics*; D002648:Child; D003872:Dermatitis / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005799:Genes, Dominant; D006105:Granulomatous Disease, Chronic / Q000235:genetics*; D006801:Humans; D007500:Iritis / Q000235:genetics*; D008297:Male; D010375:Pedigree; D012507:Sarcoidosis / Q000175:diagnosis; D013577:Syndrome