title: [Effect of immunostimulants on kidney tubule secretion of xenobiotics].
abstract: Excretion of cardiotrast (diotrast) was used to study tubular secretion of organic compounds in rats. Immunostimulants prodigiosin (0.05 mg/kg) and levamisole (10 mg/kg) injected subcutaneously three times every other day increased cardiotrast excretion. High levamisole dose (50 mg/kg), having no stimulating effect on the immunity, failed also to influence tubular cardiotrast transport. Possible mechanisms of immunostimulants' action on the tubular secretion of xenobiotics is discussed.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D007468:Iodopyracet / Q000652:urine; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism*; D007978:Levamisole / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D051381:Rats
chemical_list: D000276:Adjuvants, Immunologic; D011135:Polysaccharides, Bacterial; D007978:Levamisole; D011354:Prodigiozan; D007468:Iodopyracet
vernacular_title: Vliianie immunostimuliatorov na kanal'tsevuiu sekretsiiu ksenobiotikov v pochke.