title: Anthelmintic resistance in nematode parasites of goats.
abstract: Cases of anthelmintic resistance on 3 goat farms in Gippsland were investigated. On the first farm Haemonchus contortus, Trichostrongylus colubriformis and Ostertagia (Teladorsagia) circumcincta were found to be resistant to fenbendazole, but the first 2 species were fully susceptible to levamisole. On the second farm a population of T. colubriformis, resistant to concurrent full doses of levamisole and a benzimidazole, was found to retain this resistance when transferred to sheep. On the third farm, heavy mortality due to Ostertagia and Trichostrongylus spp burdens was arrested only by the use of concurrent full doses of levamisole and oxfendazole; no single anthelmintic was found to be effective. A disturbing rise in the incidence of clinical helminthiosis, often accompanied by anthelmintic resistance, occurred on goat farms in Gippsland early in 1984.
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000627:therapeutic use; D006041:Goats / Q000469:parasitology*; D006189:Haemonchus / Q000187:drug effects; D007978:Levamisole / Q000627:therapeutic use; D009349:Nematode Infections / Q000662:veterinary*; D010028:Ostertagia / Q000187:drug effects; D010270:Parasite Egg Count; D014254:Trichostrongylus / Q000187:drug effects
chemical_list: D000969:Antinematodal Agents; D007978:Levamisole; D005273:Fenbendazole