Induction of chromosomal aberrations and sister chromatid exchanges by propane sultone in human lymphocytes in vitro.
Genotoxicological investigation of 1,3-propane sultone was undertaken using human lymphocyte cultures as the test system. Concentrations greater than 1 mM induced appreciable chromosomal aberrations, which increased proportionally to the dose or the duration of treatment. It was also observed that treatment administered at 45 degrees C produced almost 3 times more abnormal cells than at 37 degrees C. The chemical also produced a significantly higher frequency of SCEs.
D002273:Carcinogens; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013696:Temperature; D013876:Thiophenes / Q000633:toxicity*
D002273:Carcinogens; D009153:Mutagens; D013876:Thiophenes; C003218:1,3-propane sultone