[Effect of septal damage on alcoholic motivation in the rat].
Interconnection between predisposition to depressive-like state (DS) in stress situation and heightened addiction to ethanol was studied in nonlinear male white rats. Electrolytic lesion of the septum in animals inclined to the development of DS, led to a change from the passive type of reaction in stress conditions to the active type. The rate of formation of alcoholic motivation in these animals decreased in comparison with sham-operated rats. The effect of the septal lesion in rats with formed addiction to alcohol was less expressed. Conclusion is made that the passive type of reaction in extreme conditions is significant for the formation of alcohol motivation in rats, especially at early stages.
D000437:Alcoholism / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D001931:Brain Mapping; D003863:Depression / Q000150:complications / Q000503:physiopathology; D004198:Disease Susceptibility; D008297:Male; D009042:Motivation / Q000502:physiology*; D051381:Rats; D012688:Septum Pellucidum / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology
Vliianie povrezhdeniia peregorodki na alkogol'nuiu motivatsiiu u krys.