title: Standing potential and c-wave during changes in PO2 and flow in the perfused cat eye.
abstract: Changing flow rate (F) in arterially perfused cat eyes concomitantly alters the supply of O2 and greatly affects electrical signals: increasing F increases the standing potential (SP) and decreasing F induces the opposite. Corresponding effects on c-wave are more variable. To separate changes in supply of O2 from changes in F we performed two types of experiments: (1) changing supply of O2 while keeping F constant; this was done by switching to a perfusate of different PO2: and (2) changing F while keeping the supply of O2 constant; this was done by switching to hypoxic or hyperoxic perfusates and adjusting F to keep the b-wave amplitude constant. Results (1): Decrease in PO2 left the SP essentially unaffected, but increased the c-wave. Increase in PO2 tended to increase the SP and to decrease the c-wave. Results (2): Isolated decrease in F did not affect the SP consistently and left the c-wave unchanged. Isolated increase in F often increased the SP, but also left the c-wave unchanged. Covariation between SP and amplitude to the c-wave was absent during hyperoxia.
mesh_terms: D000818:Animals; D002415:Cats; D004596:Electroretinography; D005123:Eye / Q000378:metabolism; D009799:Ocular Physiological Phenomena; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D010477:Perfusion / Q000295:instrumentation
chemical_list: D010100:Oxygen