Lipid peroxidation in liver mitochondria from copper-loaded rats.
The amount of phospholipids in liver mitochondria decreased after chronic alimentary copper-loading of rats (40 mg CuSO4 per rat per day in the course of two weeks), while 24 hours after a single intraperitoneal injection of copper (20 mg CuSO4 per kg body weight) it remained unchanged, notwithstanding that both copper treatments highly increased the copper level in mitochondria. Alimentary copper-loading led to a decrease in the relative proportions of the majority of unsaturated fatty acids in mitochondrial phospholipids. Both the spontaneous and Fe2+-induced formation of malonaldehyde were more enhanced in the mitochondria from the two experimental groups as compared to the controls.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D008930:Mitochondria, Liver / Q000032:analysis / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D008054:Lipid Peroxides; D010743:Phospholipids; D008315:Malondialdehyde; D003300:Copper