Protection against acute ethanol toxicity in mice by zinc aspartate, glycols, levulose and pyritinol.
The lethality in mice after an acute intraperitoneal challenge with ethanol could be largely prevented by treatment with single doses of zinc aspartate. Other zinc salts or aspartates were not or clearly less effective than zinc aspartate. Marked protection was also provided by polyethylene glycol and propylene glycol. The antagonistic effects of levulose and pyritinol against acute ethanol intoxication were confirmed.
D000435:Alcoholic Intoxication / Q000517:prevention & control*; D000818:Animals; D001224:Aspartic Acid / Q000627:therapeutic use; D002849:Chromatography, Gas; D005260:Female; D005632:Fructose / Q000627:therapeutic use*; D006018:Glycols / Q000627:therapeutic use*; D051379:Mice; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011409:Propylene Glycols / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use*; D011746:Pyrithioxin / Q000627:therapeutic use*; D013997:Time Factors; D015032:Zinc / Q000627:therapeutic use*
D006018:Glycols; D011409:Propylene Glycols; D011725:Pyridines; D005632:Fructose; D001224:Aspartic Acid; D011092:Polyethylene Glycols; D011746:Pyrithioxin; D015032:Zinc