title: Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies.
abstract: Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1 beta was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D005346:Fibroblast Growth Factors / Q000302:isolation & purification*; D006728:Hormones; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009419:Nerve Tissue Proteins; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D006728:Hormones; D009419:Nerve Tissue Proteins; D005346:Fibroblast Growth Factors