Inflammatory pseudohistoplasmosis.
In patients with multifocal choroiditis, presumed ocular histoplasmosis syndrome (POHS) is often diagnosed. However, POHS typically is not associated with inflammatory activity in the ocular media. A group of patients had a pattern of multifocal choroidal spots reminiscent of POHS with active signs of inflammation in the anterior and vitreous chambers. Of the 28 patients, 43% were black. In addition to inflammation, many patients had peripapillary atrophy (39%) or diskiform macular scars (32%). Of those with diskiform scars, 33% were black. Systemically, 32% of the patients were presumed to have sarcoidosis; 29%, tuberculosis; 11%, syphilis; and 28%, no etiology. In some cases, treatment of the underlying disease resulted in improvement of the ocular findings. Inflammatory pseudohistoplasmosis syndrome appears to be a nonspecific response to a number of uveitic syndromes, including sarcoidosis, tuberculosis, and syphilis.
D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000473:pathology; D044383:Black People; D002825:Chorioretinitis / Q000473:pathology; D002833:Choroiditis / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006660:Histoplasmosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis; D013587:Syphilis / Q000150:complications / Q000175:diagnosis; D014376:Tuberculosis / Q000150:complications / Q000175:diagnosis; D014607:Uveomeningoencephalitic Syndrome / Q000473:pathology; D044465:White People