Fenfluramine and mazindol: acute reversible cardiomyopathy associated with their use.
An unusual side effect of amphetamine-like drugs is described. A patient with acute cardiomyopathy was discovered to have been taking Fenfluramine and Mazindol at the prescribed dose. Within a week after abstention from the drugs and appropriate cardiac treatment her cardiomyopathy resolved. The authors suggest that this effect is due to the combination of the two drugs and represents a drug interaction.
D000328:Adult; D009202:Cardiomyopathies / Q000139:chemically induced*; D004347:Drug Interactions; D004562:Electrocardiography; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D008454:Mazindol / Q000009:adverse effects*
D007211:Indoles; D005277:Fenfluramine; D008454:Mazindol