title: [Comparative study of the sensitizing activity of heterologous serum preparations].
abstract: Experiments on guinea pigs and adrenalectomized mice showed that the anaphylactogenic properties xenogenic immunoglobulin preparations were 2- to 2.5-fold higher than those of antitoxic sera "Diaferm-3". The partial acid-enzymatic hydrolysis of immunoglobulin preparations obtained by ethanol fractionation permitted a considerable decrease in their sensitizing activity and anticomplementary properties.
mesh_terms: D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D002850:Chromatography, Gel; D003168:Complement Fixation Tests; D006041:Goats / Q000276:immunology; D006168:Guinea Pigs; D006736:Horses / Q000276:immunology; D006868:Hydrolysis; D007106:Immune Sera / Q000032:analysis / Q000276:immunology* / Q000302:isolation & purification; D007114:Immunization; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000276:immunology; D051379:Mice
chemical_list: D007106:Immune Sera; D007136:Immunoglobulins
vernacular_title: Sravnitel'noe izuchenie sensibiliziruiushcheĭ aktivnosti geterologichnykh syvorotochnykh preparatov.