title: The progression of behavioral and pathological effects of the parasite Toxocara canis in the mouse.
abstract: Toxocara canis, the parasitic roundworm of the dog may infect aberrant hosts including mice and humans. The present study examined the behavioral and pathological changes at each of three postintubation periods (Period 1: 8-10 days, 2: 49-51 days, and 3: 84-86 days postintubation, respectively) in independent groups of mice intubated with 1000 eggs of T. canis. Eight-ten days after intubation Toxocara infected animals typically showed depressed levels of activity relative to saline-intubated controls. The scope and severity of behavioral changes were attenuated when different mice were tested 49-51 days after infection, and then became more severe when the third set of animals was tested 84-86 days after intubation. While brain pathology increased over the three periods, visceral organs showed marked pathology 8-10 days after intubation followed by a decrease in severity. These data suggest that Toxocara associated pathological changes in visceral organs and in the brain have behavioral consequences in mice. Given the similarity in migratory pathways of this parasite in rodents and humans, and the findings of T. canis larvae in human brain tissue, the results of this animal study may have implications concerning the possible etiology of behavioral disorders for children who have a known history of pica for dirt.
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000473:pathology*; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology*; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D051379:Mice; D009043:Motor Activity; D009425:Nesting Behavior; D011596:Psychomotor Disorders / Q000209:etiology; D011930:Reaction Time; D014120:Toxocariasis / Q000150:complications / Q000473:pathology*