Effect of disulfiram in experimentally induced vitamin E deficiency myopathy in lambs.
Vitamin E deficiency myopathy (white muscle disease) was induced in 14 suckling lambs (2 experiments; 7 lambs/experiment) by addition of cod liver oil to the diet. Disulfiram, an antioxidant, was administered orally once each day to 8 of the 14 lambs at 2 different doses. Serum creatine kinase (CK) activity was measured weekly for 5 weeks. Increased CK activity was evident in some lambs beginning at week 3. By week 4, serum CK was abnormally increased in 5 of the 6 nontreated lambs (ie, disulfiram not given) and in 4 of the 8 treated lambs. The combined disulfiram groups had significantly lower serum CK values during the study (P less than 0.05). Serum alpha-tocopherol, measured on samples from week 5 for lambs of experiment 1, was significantly higher in treated lambs (P less than 0.01). Microscopic examination of the vastus lateralis muscle indicated that the most severe lesions, consistent with nutritional myopathy, were seen in nontreated lambs. Therefore, disulfiram may have an antioxidant effect in lambs with vitamin E deficiency.
D000818:Animals; D004221:Disulfiram / Q000627:therapeutic use*; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000662:veterinary*; D014912:White Muscle Disease / Q000188:drug therapy*
D004221:Disulfiram