[Principle of plotting the age distribution of persons with hereditary diseases at various ages of onset and differential mortality].
A method for ascertaining the mode of current age distributions is suggested for accurate quantitative assessment of some genetic parameters of hereditary diseases, such as age-specific penetrance, frequency of heterozygotes in the general population, fitness. The method is based on estimating the age-specific proportion of affected among the total number of heterozygotes, which seems more reasonable than the common methodology, considering the age-specific proportion of affected among all cases of the disease indicated.
D000367:Age Factors; D004812:Epidemiologic Methods; D006580:Genetic Carrier Screening / Q000379:methods; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000401:mortality; D005828:Genetics, Population; D006801:Humans
Printsip postroeniia raspredeleniĭ porazhennykh ot vozrasta v sluchaiakh analiza nasledsvtennykh zabolevaniĭ s var'iruiushchim vozrastom manifestatsii i differentsial'noĭ smertnost'iu.