Heterochromatic C-bands of chromosome 1 in ovarian cancer patients.
Lymphocyte cultures of 13 patients with ovarian cancer and of seven controls have been used to investigate the C-band lengths of the homologs of chromosome 1. The measurements were performed with the semiautomatic image analysis system Leitz A.S.M. A more than 25% difference in size of the C-bands was more frequent in metaphases of the cancer group (43.8%) than in those of the control group (19.5%). In the cancer group smaller C-bands were found. Especially in the A2-chromosomes the C-bands were smaller than in the same chromosomes of the control group.
D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic