The compression of granulates containing solid dispersions.
In the present work granulates containing solid dispersions of diazepam were compressed into tablets. The results show that polyethyleneglycol (PEG 6000) give the best tablets which disintegrate when a strong disintegrant is added extragranularly. The tablets keep their good physical properties when stored in normal or low humidity conditions.
D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D004355:Drug Stability; D006813:Humidity; D011092:Polyethylene Glycols; D011208:Powders; D011312:Pressure; D012995:Solubility; D013607:Tablets
D011208:Powders; D013607:Tablets; D011092:Polyethylene Glycols