Transient enhancement of serum somatomedin levels prior to weaning of growth-impaired vasopressin-deficient Brattleboro rats.
Somatomedin serum levels of congenitally vasopressin-deficient Brattleboro rats were determined postnatally between day 1 and 55, and compared with heterozygous control values. Assays were performed with a radioimmunoassay of insulin-like growth factor 1 (IGF-1). A transient enhancement of immunoreactive IGF-1 levels between day 8 and 21 of age and a reduction in adulthood was found. This observation shows that the early growth impairments of the Brattleboro mutant are not due to a deficiency of IGF-1.
D000818:Animals; D001835:Body Weight; D005260:Female; D006130:Growth Disorders / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011910:Rats, Brattleboro; D013002:Somatomedins / Q000097:blood*; D014667:Vasopressins / Q000172:deficiency*; D014886:Weaning
D013002:Somatomedins; D014667:Vasopressins