title: Negative observations on immunological side effects of rifampin and dapsone in mice.
abstract: The in vivo effects of rifampin and dapsone on immunological responses were investigated using mice immunized with sheep erythrocytes. The number of cells producing antibody was not affected by a clinical (1 CD) or a threefold excess dose (3 CD) of the drugs administered for ten days. A similar result was obtained in an experiment using a mouse strain known to be low responders to the antigen. Induction of suppressor cells acting on antibody production was not influenced by 3 CD or 6 CD of the drugs. Neither delayed-type hypersensitivity nor induction of the suppressor cell population acting on delayed hypersensitivity was affected by 3 CD of the drugs. Phagocytosis of sheep erythrocytes by peritoneal cells and the growth of a tumor were not altered by 6 CD of the drugs.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003622:Dapsone / Q000494:pharmacology*; D005260:Female; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007917:Leprostatic Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D012293:Rifampin / Q000494:pharmacology*; D010948:Viral Plaque Assay
chemical_list: D007917:Leprostatic Agents; D003622:Dapsone; D012293:Rifampin