[Structural and biochemical characteristics of the effectiveness of intraoperative protection of the myocardium].
Results of morphological and biochemical examination of 153 myocardium biopsies from 42 patients with the intraoperational heart ischemia that developed during the correction of cardiac valves disturbances under the condition of artificial circulation and cardioplegia with the blood based solution are given. Phosphocreatin ("neoton" produced by Schiapparelli Company, Italy) was added as a cardioprotector to the cardioplegic solution in 24 patients. The high efficiency of the drugs for the cardiomyocytes sarcolemma is shown by means of colloidal lanthanum. A full retention of the macroergic phosphates is also shown biochemically when the standard solution was modified for the heart protection.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D003401:Creatine / Q000378:metabolism; D006324:Heart Arrest, Induced / Q000379:methods*; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D009206:Myocardium / Q000648:ultrastructure*; D010725:Phosphocreatine / Q000008:administration & dosage* / Q000378:metabolism; D012508:Sarcolemma / Q000378:metabolism / Q000648:ultrastructure
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D003401:Creatine
Strukturno-biokhimicheskaia kharakteristika éffektivnosti intraoperatsionnoĭ zashchity miokarda.