Phospholipid patterns and phospholipase A2 activities in gastric mucosa of rats developing carcinomas after surgically induced enterogastric reflux.
Phospholipid patterns of the gastric mucosa from rats after operations inducing enterogastric reflux showed characteristic differences in relation to control rats: diminution of parent phospholipids phosphatidylethanolamine and phosphatidylcholine concomitant with increases of the corresponding lysophospholipids, increase of the sphingomyelin portion, indications for lipid peroxidations possibly connected with small drops of acidic phospholipids, and an elevated phospholipase A2 activity. The observed phospholipid changes support the assumption of disturbed membrane functions caused by activation of lipolytic activities as one factor involved in progressive mucosal alterations mostly manifested as carcinomas of the stomach.
D000230:Adenocarcinoma / Q000209:etiology / Q000378:metabolism; D000818:Animals; D004383:Duodenogastric Reflux / Q000150:complications; D005753:Gastric Mucosa / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000209:etiology / Q000378:metabolism*
D010743:Phospholipids; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2