Retrovirus-like particles associated with myeloproliferative disease in the dog.
A case of granulocytic myeloproliferative disease with hypercalcaemia of malignancy in a 6-year-old Golden Retriever dog is described. Numerous retrovirus-like budding particles were observed at the cell surface of the neoplastic granulocytes, suggesting the presence of a new oncogenic virus. Several attempts by other workers to demonstrate the presence of an oncogenic retrovirus in canine lymphosarcoma have produced minimal results. This study suggests that non-lymphoid canine myeloproliferative disorders warrant further investigation.
D000818:Animals; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D005260:Female; D008854:Microscopy, Electron; D009196:Myeloproliferative Disorders / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012190:Retroviridae / Q000302:isolation & purification*; D012509:Sarcoma / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*