title: [Myambutol (ethambutol)-induced retinoneuritis].
abstract: A retinoneuritis due to ethambutol (Myambutol) occurs with Myambutol doses of over 20 mg/kg per day after 3 weeks to 15 months. Visual acuity can deteriorate within the following 6 months even after immediate discontinuation of treatment with Myambutol. It may recover 2 months (though in some cases only 16 months) after the onset of the deterioration; in cases of optic atrophy a more severe loss of vision usually remains. If there was loss of vision to 1/10 or less there was in most cases no change in the visual acuity. On the other hand, a primary loss of vision to only 0.3 or 0.4 usually ended with recovery of full vision. The occasionally observed clinical picture of a reddish optic disk, retinal hemorrhages, a very fine granular pigment alteration of the macular region, and loss of vision for more than a year without optic disk pallor suggests a toxic retinitis or retinoneuritis rather than neuritis. This is confirmed by electrophysiological observations.
mesh_terms: D000328:Adult; D000368:Aged; D004977:Ethambutol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000139:chemically induced; D009902:Optic Neuritis / Q000139:chemically induced*; D012166:Retinal Hemorrhage / Q000139:chemically induced; D012173:Retinitis / Q000139:chemically induced*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D004977:Ethambutol
vernacular_title: Myambutol (Ethambutol) bedingte Retinoneuritis.