Interaction between the effects of centrally administered arecoline and leucocyte pyrogen on the activity of posterior hypothalamic neurons in the rabbit.
In experiments with urethane-anesthetized rabbits, the alteration in the activity of posterior hypothalamic neurons resulting from intracerebroventricular injection of leucocyte pyrogen was attenuated by subsequent administration of arecoline. Atropine failed to alter the neuronal response to leucocyte pyrogen but abolished the effect of arecoline. The neuronal response to arecoline was reversed in the absence of leucocyte pyrogen.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D004347:Drug Interactions; D004594:Electrophysiology; D007031:Hypothalamus / Q000502:physiology*; D007034:Hypothalamus, Posterior / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D007375:Interleukin-1; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011506:Proteins / Q000494:pharmacology*; D011817:Rabbits
D007375:Interleukin-1; D011506:Proteins; C008270:leukocyte endogenous mediator; D001115:Arecoline; D001285:Atropine