Synthesis and hypoglycemic activity of N-alkylated hydrazonopropionic acids.
A series of N-alkylated 2-hydrazonopropionic acids have been synthesized and evaluated for their hypoglycemic activity. Most of the compounds exhibit a remarkable blood glucose lowering activity in fasted guinea pigs. Some of the structural variables studied were the effects of branching, unsaturation, or substitution on the alkyl side chain and the effect of nuclear substitution on the aralkyl analogues. From these compounds, 2-[[(E)-2-methyl-3-phenyl-2-propenyl]hydrazono]propionic acid (BM 42.304; 42) was selected for further investigation.
D000818:Animals; D002333:Carnitine Acyltransferases / Q000037:antagonists & inhibitors; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D011422:Propionates / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D006835:Hydrazones; D007004:Hypoglycemic Agents; D011422:Propionates; D002333:Carnitine Acyltransferases; D005947:Glucose