Stevens-Johnson syndrome during an immunosuppressive therapy with cyclophosphamide and prednisone.
Corticosteroids are often recommended for the treatment of severe Stevens-Johnson syndrome. We report about a 12 years old boy, who developed this syndrome during an immunosuppressive therapy with prednisone and cyclophosphamide for a frequent relapsing, steroid-dependent nephrotic syndrome. Most of the commonly mentioned etiologic factors for erythema exudativum multiforme could be excluded. The usefulness of corticosteroids for the therapy seems to be doubtful.
D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy; D011241:Prednisone / Q000009:adverse effects*; D012008:Recurrence; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000473:pathology; D013997:Time Factors
D003520:Cyclophosphamide; D011241:Prednisone