Mania after withdrawal of isocarboxazid.
Two cases of mania following the discontinuation of treatment with isocarboxazid are described. Although this phenomenon has been reported by several investigators to occur after cessation of tricyclic antidepressant therapy, there exists only one isolated report of hypomania after discontinuation of monoamine oxidase inhibitors. Possible mechanisms for the occurrence of hypomania and mania after withdrawal from antidepressants are discussed.
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006801:Humans; D007520:Isocarboxazid / Q000009:adverse effects*; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000209:etiology
D007520:Isocarboxazid; D004298:Dopamine