[Stimulation of the immune system with polyvinylpyrrolidone in patients with cancer of the larynx].
Clinico-immunologic studies showed recurrence and metastatic spread to involve disorders in the synthesis of serum and, particularly, secretory immunoglobulins (M, As) in radically-treated cases of laryngeal cancer. Polyvinylpyrrolidone challenge was intended to stimulate the predominant synthesis of IgM in the blood and, particularly, saliva of the patients. Recurrence and metastatic spread incidence decreased three-fold within 4 years as a result of preoperative intratonsillary immunization with polyvinylpyrrolidone (mol. wt. 40,000).
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects*; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011205:Povidone / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D013268:Stimulation, Chemical
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011205:Povidone
Stimuliatsiia immunnoĭ sistemy polivinilpirrolidonom u bol'nykh rakom gortani.