[Results of treatment with human growth hormone in children with pituitary insufficiency under 7 years of age. Study of 26 cases].
Twenty-six children below age 7 years with idiopathic growth hormone deficiency have been treated with hGH for 2 years. Bone ages were inferior to 3 years and growth retardation averaged 3.9 +/- 0.9 standard deviation (SD) below the population mean. Results were compared to those obtained in a control group of 29 prepubertal patients, aged more than 7 years, and treated with hGH according to the same protocol. The mean height gains during the first and second year of treatment were respectively 8.4 +/- 1.8 cm and 6.6 +/- 1.5 cm. These values are significantly higher than those obtained in the group of older children. However within 2 years of treatment the initial catch-up in height of 0.9 +/- 0.6 DS was not different. In conclusion, we did not observe a better catch up growth in children before 7 years of age than in older prepubertal children, in spite of using higher doses of hGH.
D000367:Age Factors; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy*; D007223:Infant; D013997:Time Factors
D013006:Growth Hormone
Résultats du traitement par l'hormone de croissance humaine chez les enfants insuffisants hypophysaires âgés de moins de 7 ans. Etude de 26 observations.