Smooth muscle proliferation in chronically injured canine pulmonary arteries is reduced by a potent platelet aggregation inhibitor U-53,059.
Dirofilaria immitis (DI) infection chronically injures canine pulmonary arteries. This injury produces endothelial cell loss, platelet/leukocyte adhesion, and smooth muscle proliferation. In the present study we assessed the effect of the cyclooxygenase inhibitor, U-53,059, on platelet function, platelet kinetics, coagulation, and smooth muscle proliferation in DI infected dogs. Platelet aggregation to the combination of arachidonic acid/ADP was significantly inhibited by U-53,059. Coagulation and hematologic parameters were not effected by either DI infection or U-53,059 treatment. Platelet survival and the number of platelet dense granules were reduced in DI infection. Quantification of the lesions demonstrated that U-53,059 reduced both severity and density compared to non-treated dogs. U-53,059 is a potent and effective inhibitor of platelet aggregation which modifies smooth muscle proliferation produced by chronic vascular injury.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D002455:Cell Division / Q000187:drug effects; D004183:Dirofilaria immitis / Q000472:pathogenicity; D004184:Dirofilariasis / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D010974:Platelet Aggregation / Q000187:drug effects*; D011651:Pulmonary Artery / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D013844:Thiazoles / Q000494:pharmacology*
D013844:Thiazoles; C035025:itazigrel