Stress-induced analgesia in the mouse: strain comparisons.
Inescapable footshock is capable of differentially activating opioid- and non-opioid-mediated mechanisms of stress-induced analgesia in the rat, depending on the temporal and intensive parameters of its administration. In this study we compared the effects of opioid and non-opioid stress analgesia in two strains of mice, one known to be deficient in central opioid binding sites (CXBK) and one normal in this regard (C57BL/6BY). We found that although the C57 strain showed robust opioid and non-opioid stress analgesia, the CXBK strain only showed stress analgesia of the non-opioid type.
D000698:Analgesia; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D004723:Endorphins / Q000378:metabolism; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D013045:Species Specificity; D013312:Stress, Physiological / Q000503:physiopathology*
D004723:Endorphins; D009270:Naloxone; D009020:Morphine