title: Effects of chronically elevated intake of sweet solutions on sexual behavior of male rats.
abstract: Three experiments were conducted on the sexual behavior of gonadally intact and castrated male Sabra rats. Half of the animals drank water during the course of the experiment and half were offered sweet solutions, the assumption being that sweet gustatory stimulation elevates the level of central endogenous opioid peptides in rats. The effects on sexual behavior of the following drugs were explored: the opiate receptor blocker naloxone (5 mg/kg, sc), the serotonin precursor 5-hydroxytryptophan (5-HTP) (20 mg/kg, sc), the serotonin antagonist methysergide (1 mg/kg, sc), and naloxone in combination with methysergide. Naloxone, whether administered alone or in combination with methysergide, impaired sexual performance in castrated male rats, and in gonadally intact rats maintained on sweet solutions. Methysergide elevated sexual behavior in all groups, whereas 5-HTP tended to suppress such behavior. The results support the hypothesis that endogenous opiates play a role in the expression of male sexual behavior in rats. While subtle in intact animals this role may become crucial following the disruption of sex hormone supply. Serotonergic influence on male sexual behavior is inhibitory.
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004723:Endorphins / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009919:Orchiectomy; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D013649:Taste / Q000502:physiology*; D013737:Testis / Q000502:physiology
chemical_list: D004723:Endorphins; D012701:Serotonin; D012439:Saccharin; D005947:Glucose; D008784:Methysergide