Inhibition by ethanol of cardiac protein synthesis in the rat.
Protein synthesis and degradation were measured in the hearts of rats fed on diets containing 27% of calories as ethanol. Feeding of ethanol decreased the rate of synthesis of mixed cardiac proteins but was without effect on the rate of breakdown of myofibrillar and sarcoplasmic proteins. Concentrations of RNA in the hearts were not altered by ethanol feeding, indicating a decrease in RNA activity for protein synthesis.
D000818:Animals; D001835:Body Weight; D002250:Carbon Radioisotopes; D002254:Carbonates / Q000378:metabolism; D004032:Diet; D002149:Energy Intake; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009210:Myofibrils / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D012737:Sex Factors; D014443:Tyrosine / Q000378:metabolism
D002250:Carbon Radioisotopes; D002254:Carbonates; D000431:Ethanol; D014443:Tyrosine; C005686:sodium carbonate