title: Dry ice cryoamputation: a twelve-year experience.
abstract: Amputation done on an emergency basis of severely ischemic or infected limbs in critically ill patients frequently results in increased morbidity and mortality. To evaluate the effect of delaying an inevitable operative amputation by a simplified method of freezing the involved extremity, the records of 56 patients who underwent preoperative cryoamputation during a 12-year period were reviewed. Data concerning risk factors, associated medical conditions, local or systemic signs of sepsis, level of amputation, morbidity, and mortality were analyzed. Following cryoamputation of 57 limbs, 16 above-knee amputations (AKA) and 41 below-knee amputations (BKA) were performed. The overall mortality rate associated with cryoamputation was 14% (8 of 57); four postoperative deaths occurred in both the AKA and BKA groups. The mortality rate for 1021 primary operative major amputations during the same period was 7% (p less than 0.04). The only factor identified that significantly affected survival following cryoamputation was diabetes mellitus, which was present in 68% of surviving patients and in 12% of those who died (p less than 0.001). This experience suggests that cryoamputation is a valuable, simple technique that allows for deliberate stabilization and preparation of seriously ill, septic patients prior to surgical procedures, which, when performed on an emergency basis have been associated with mortality rates exceeding 40%.
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical / Q000379:methods* / Q000401:mortality; D003452:Cryosurgery / Q000379:methods* / Q000401:mortality; D004367:Dry Ice / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007866:Leg / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D004367:Dry Ice