The interaction of blood components with PDMS (polydimethylsiloxane) and LDPE (low-density polyethylene) in a baboon ex vivo arteriovenous shunt model.
The interaction of 111Indium-labeled platelets, and other blood components with the luminal surface of polydimethylsiloxane (PDMS) and low-density polyethylene (LDPE) was determined using an ex vivo arteriovenous shunt in the baboon. Both PDMS and LDPE showed little platelet accumulation at either high (200 cc/min) flow rates. PDMS accumulated more platelets at low than at high flow. When the surfaces of PDMS and LDPE were examined under scanning electron microscopy after 2.5 h of flow in the shunt circuit, red and white blood cells were attached. Platelets appeared to be confined to patchy areas covered by a fibrinlike network. The low platelet reactivity of LDPE and PDMS suggests their potential use as coatings for conventional, more platelet reactive vascular graft materials.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects; D001672:Biocompatible Materials; D001790:Blood Physiological Phenomena; D001792:Blood Platelets / Q000502:physiology; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D002448:Cell Adhesion; D004129:Dimethylpolysiloxanes; D008297:Male; D008855:Microscopy, Electron, Scanning; D010215:Papio; D011095:Polyethylenes; D012039:Regional Blood Flow
D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D011095:Polyethylenes