title: Assessment of electron irradiation damage to biomolecules using the Patterson function.
abstract: A method for the assessment of electron radiation damage to 5-iodouracil is described which involves the use of the Patterson function. Changes in Patterson maps computed from the electron diffraction patterns recorded at increasing electron irradiation have been related to structural and chemical damage to 5-iodouracil. The process of radiation damage is also discussed in terms of a disorder parameter which was found to increase with increasing irradiation.
mesh_terms: D008433:Mathematics; D008854:Microscopy, Electron / Q000009:adverse effects*; D008954:Models, Biological; D008968:Molecular Conformation / Q000528:radiation effects; D014498:Uracil / Q000031:analogs & derivatives* / Q000528:radiation effects; D014961:X-Ray Diffraction
chemical_list: C100034:iodouracil; D014498:Uracil