Protector effects of an anti-heart immune serum on guinea-pig atrial and papillary muscle in digitalis intoxication.
An anti-heart immune serum (IS) has been tested to prevent digitalis intoxication in guinea-pig atrial and papillary muscle. The results show a good protector effect of the IS against the cardiotoxic effects of digitoxin. The hypothesis of an interaction between the IS and the affinity binding sites of the cardiotonic glycosides can be retained.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004071:Digitalis Glycosides / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004074:Digitoxin / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects; D007106:Immune Sera / Q000494:pharmacology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000276:immunology*; D010210:Papillary Muscles / Q000187:drug effects
D004071:Digitalis Glycosides; D007106:Immune Sera; D004074:Digitoxin