[Central cholinolytic effect of tropane derivatives: structure-activity relationship].
The effect of two tropane derivatives on the electric neuronal activity in sensorimotor cortex was studied in rabbits using microiontophoretic method. Unlike atropine they lack aryl and hydroxyl, but possess morpholine and piperazine. The effects of both drugs were opposite to those of acetylcholine. Simultaneous application of tropane derivatives and acetylcholine to one neuron decreased both excitatory and inhibitory neuronal responses to acetylcholine. It is concluded that aryl and hydroxyl are not necessary for tropane derivatives to reveal their central cholinolytic activity.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001286:Atropine Derivatives; D010276:Parasympatholytics / Q000494:pharmacology*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects*
D001286:Atropine Derivatives; D010276:Parasympatholytics; C047092:atropine beta-(N-morpholinyl)propionate; C047091:atropine beta-(N-methylpiperazinyl)propionate; D001285:Atropine
Tsentral'nyĭ kholinoliticheskiĭ éffekt proizvodnykh tropana: sviaz' struktury i deĭstviia.