Abnormally low UV-induced unscheduled DNA synthesis in cells from a patient with hydroa vacciniforme.
Skin fibroblasts from a patient with the photosensitive disorder hydroa vacciniforme were tested in vitro for DNA repair capacity. The rate of ultraviolet light (254 nm)-induced unscheduled DNA synthesis (UDS) in these fibroblasts was found to be 51-59% of the rate found in 4 normal fibroblasts strains. The patient had none of the clinical signs of the classic DNA deficient disease, xeroderma pigmentosum.
D000328:Adult; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000528:radiation effects; D005260:Female; D006801:Humans; D006837:Hydroa Vacciniforme / Q000235:genetics*; D066298:In Vitro Techniques; D014466:Ultraviolet Rays
D004247:DNA