title: [Concentrations of free and bound 4-aminobutyric acid in human serum: reference values].
abstract: A rapid and sensitive procedure is described for the quantification of gamma-aminobutyric acid in human plasma, using ion-exchange fluorescence. Analytical values for gamma-aminobutyric acid vary according to the method of deproteinization, storage conditions and sample treatment. A practicable and precise method for the evaluation of free and bound gamma-aminobutyric acid is presented. The mean concentration of the free neurotransmitter in neurologically normal control subjects was 142.4 +/- 13.1 nmol/l (n = 30). The mean concentration of the bound form was 438.6 +/- 51.1 nmol/l in the same subgroup.
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D011485:Protein Binding; D012016:Reference Values; D013050:Spectrometry, Fluorescence; D014462:Ultrafiltration; D005680:gamma-Aminobutyric Acid / Q000097:blood*
chemical_list: D001798:Blood Proteins; D005680:gamma-Aminobutyric Acid
vernacular_title: Konzentrationen von freier und gebundener 4-Aminobuttersäure im menschlichen Serum: Referenzbereiche.