Human milk-derived growth factor prevents duodenal ulcer formation.
Human milk was fractionated to obtain a partially purified growth factor preparation. The growth factor in this fraction, designated as human milk growth factor III, exhibits chromatographic and biological characteristics similar to epidermal growth factor-urogastrone. Pretreatment of mice with human milk growth factor III significantly reduces the incidence, number, total length, and severity score of cysteamine-induced duodenal ulcers.
D000818:Animals; D002850:Chromatography, Gel; D003543:Cysteamine; D004305:Dose-Response Relationship, Drug; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D006133:Growth Substances / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008895:Milk, Human / Q000032:analysis*
D006133:Growth Substances; D003543:Cysteamine