title: Clinicopathologic correlate of a fresh eyelid pigment implantation.
abstract: An eyelid with freshly applied black eyeliner pigment was examined histologically. X-ray microanalysis of the pigment suspension from the manufacturer's vial indicated that its composition was 98% iron and 2% titanium. Transmission electron microscopic examination disclosed that particles were in the extracellular matrix; intracellular particles were not seen. By light microscopy, implant material was detected in various levels of the dermis and was found in dermal lymphatics as well as within and surrounding a hair follicle. Our study suggests that systemic exposure to the implant material is possible and offers explanations for permanent eyelash loss, which we have seen following this procedure.
mesh_terms: D000368:Aged; D004577:Electron Probe Microanalysis; D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure; D005143:Eyelids / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010860:Pigments, Biological / Q000378:metabolism; D013057:Spectrum Analysis; D013653:Tattooing / Q000009:adverse effects*
chemical_list: D010860:Pigments, Biological