[Enzyme activity and content of glycerophosphate shuttle metabolites in the cortex and medulla oblongata during hyperbaric oxygenation therapy of acute hemorrhage].
The experiments on cats have demonstrated that hyperbaric oxygenation (303.9 kPa, 60 min) in acute blood loss (24.0 +/- 0.8 ml/kg) has an essential effect on glycerophosphate shuttle mechanism: it stimulates mitochondrial glycerol-3-phosphate dehydrogenase in the sensorimotor cortex and medulla oblongata, providing glycerol-3-phosphate dehydrogenation, activates cytoplasm hydrogen delivery to mitochondrial respiratory chain, prevents glycerol-3-phosphate and NADH level increase and cytoplasm glycerol-3-phosphate dehydrogenase inhibition, limiting lactate production.
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D005994:Glycerophosphates / Q000378:metabolism*; D006470:Hemorrhage / Q000628:therapy*; D006931:Hyperbaric Oxygenation; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D009243:NAD / Q000378:metabolism
D005994:Glycerophosphates; D009243:NAD; D005993:Glycerolphosphate Dehydrogenase
Aktivnost' fermentov i soderzhanie metabolitov glitserofosfatnogo chelnochnogo tsikla v kore i prodolgovatom mozge pri giperbaricheskoĭ kislorodnoĭ terapii ostroĭ krovopoteri.