title: Investigation of possible polymorphic drug oxidation in black South Africans.
abstract: The ability to oxidize phenacetin into paracetamol was investigated in 117 healthy South African black subjects. Statistical analysis of the amount of paracetamol excreted in the 0-8-hour urine sample revealed a normal distribution (P less than 0,05). There was thus no evidence of polymorphism; the subjects appeared to be exclusively monomorphic extensive metabolizers.
mesh_terms: D000082:Acetaminophen / Q000652:urine*; D000328:Adult; D044383:Black People; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010615:Phenacetin / Q000378:metabolism*; D011110:Polymorphism, Genetic; D013019:South Africa; D013997:Time Factors
chemical_list: D000082:Acetaminophen; D010615:Phenacetin