The effect of thiabendazole on pain threshold.
Thiabendazole significantly increased the reaction time to thermal stimulus. However, in mice treated with morphine, the reaction time was not in any way different from those treated with combined doses of thiabendazole and morphine. Thiabendazole was found to have an antinociceptive action. The protective dose for 50% of animal (ED50) against p-benzoquinone-induced writhing reflex was found to be 310 mg/kg. The ED50 for aspirin alone was 140 mg/kg. When the ED50 of aspirin was determined in combination with different dose levels of thiabendazole, it showed a marked reduction in the values reaching 50 mg/kg, when 300 mg of thiabendazole was used in combination. Toxicological studies revealed that the oral LD50 for thiabendazole in mice was 2200 mg/kg, and when combined with 140 mg/kg of aspirin, the LD50 was reduced to 900 mg/kg. These findings indicate that thiabendazole possesses an analgesic activity which is potentiated by aspirin, though aspirin was found to significantly enhance its toxicity.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D006358:Hot Temperature; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010146:Pain / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects*; D013827:Thiabendazole / Q000494:pharmacology*
D000700:Analgesics; D013827:Thiabendazole; D001241:Aspirin