[Anticonvulsive prophylaxis after juvenile craniocerebral injuries: a retrospective evaluation].
A check-up of 124 children with medium to severest contusio cerebri showed a posttraumatic late epilepsy rate of 8% at an average control period of 12 years. A third of all children received a long-term anticonvulsive prophylaxis of approximately 4 years, under which 13% showed a manifest late epilepsy, while the rate of the non-protected group was 6% (each 5 patients). Even with a full anticonvulsion therapy it was not possible to avoid further convulsion in any of the children. By these results and new publications, a posttraumatic anticonvulsive prophylaxis is questioned and it is recommended to start an anticonvulsion therapy only if late epilepsy has become definitely manifest.
D000927:Anticonvulsants / Q000627:therapeutic use*; D001924:Brain Concussion / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004827:Epilepsy / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D013997:Time Factors; D014474:Unconsciousness / Q000175:diagnosis
D000927:Anticonvulsants; D010672:Phenytoin; D010634:Phenobarbital
Die Antikonvulsionsprophylaxe nach kindlichem Schädelhirntrauma: Eine retrospektive Beurteilung.