title: Acute hypothyroidism in a 3 year old.
abstract: A 3 year old girl presented with a three week history of lethargy, constipation, and joint swelling. Investigation showed primary hypothyroidism associated with immunological changes including thyroglobulin antibodies. Reassessment several months after beginning thyroxine treatment confirmed persisting hypothyroidism. Primary hypothyroidism may present as a rapid onset disorder.
mesh_terms: D000208:Acute Disease; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000276:immunology*; D013954:Thyroglobulin / Q000276:immunology
chemical_list: D001323:Autoantibodies; D013954:Thyroglobulin