Taurine's possible protective role in age-dependent response to calcium paradox.
When hearts were reperfused with Ca++ after a short period of Ca++-free perfusion, irreversible loss of electrical and mechanical activity was observed. This phenomenon, first described by Zimmerman and Hulsmann, was termed the "calcium paradox". Chizzonite and Zak recently reported that rat hearts exhibited an age-dependent response in a calcium paradox model. The taurine (2-aminoethanesulfonic acid) content of hearts in the newborn animal is high, and decreases rapidly during the first few days of life. The present experiments were performed to test whether the myocardial taurine content was closely linked to an age-dependent response in the calcium paradox model, using post-hatched chicks. The mechanical dysfunction of the heart was much more severe in 9-day-old post-hatched chicks than in 2-day-old chicks when the hearts were subjected to the calcium paradox. Myocardial taurine content was lower in the 9-day-old chicks than in the 2-day-old chicks. The age-related response to the calcium paradox was partially protected by oral pretreatment with taurine, and there was a small increase in myocardial taurine level. It is proposed that myocardial taurine is one factor in the protection against the calcium paradox phenomenon.
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D002118:Calcium / Q000502:physiology*; D002645:Chickens; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D009929:Organ Size; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013654:Taurine; D002118:Calcium