Experimental allergic orchitis in mice. II. Association of disease susceptibility with the locus controlling Bordetella pertussis-induced sensitivity to histamine.
Susceptibility to the induction of murine autoimmune orchitis was found to be associated with the locus controlling Bordetella pertussis-induced sensitivity to the vasoactive amine, histamine. Only those inbred and H-2 congenic strains of mice possessing both the H-2d haplotype and the locus for susceptibility to B. pertussis-induced sensitivity to histamine developed autoimmune orchitis. In addition, segregation analysis of backcross generation mice also demonstrated a high degree of correlation between susceptibility both to disease and to histamine sensitization, which was indicative of additional multigene control. Pertussigen-histamine sensitization factor (P-HSF) was only effective in eliciting disease when it was administered on the same day, or within a period up to 6 days following sensitization with mouse testicular homogenate-emulsified in complete Freund's adjuvant. P-HSF induced sensitivity to histamine was not found to be associated with an increase in the vascular permeability of target tissue. Thus, B. pertussis-induced sensitivity to histamine appears to play a more crucial role during the sensitization phase of autoimmune orchitis induction, rather than at the inflammatory or effector phase of the disease.
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D002199:Capillary Permeability / Q000187:drug effects; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D004334:Drug Administration Schedule; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D006632:Histamine / Q000008:administration & dosage / Q000276:immunology*; D007114:Immunization / Q000379:methods; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009920:Orchitis / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D037342:Pertussis Toxin; D012701:Serotonin / Q000008:administration & dosage; D010566:Virulence Factors, Bordetella / Q000008:administration & dosage / Q000276:immunology*
D006183:H-2 Antigens; D010566:Virulence Factors, Bordetella; D012701:Serotonin; D006632:Histamine; D037342:Pertussis Toxin