title: Screening for eye irritancy using cultured HeLa cells.
abstract: To investigate whether toxicity tests on HeLa cells were predictive of eye irritancy, 18 compounds of known eye irritancy and in vitro cytotoxicity were tested on HeLa cells in the MIT-24 system. The results correlated well with eye irritancy as determined by the Draize test in rabbits for 16 of the test substances, but failed to detect the high eye irritancy of 1-heptanol and allyl alcohol, both of which were cytotoxic in other cellular systems.
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007509:Irritants / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D007509:Irritants