[Characteristics of early disorders of fatty-acid composition of kidney lipids in spontaneous (hereditary) arterial hypertension].
Fatty acid composition of kidney lipids from spontaneously hypertensive Okamoto-Aoki rats (SHR) and normotensive Wistar rats (NR) was investigated two days after birth by gas-liquid chromatography. In SHR kidney phospholipids, as compared to the respective NR values, the content of arachidonic acid (20:4n6) was decreased and the levels of oleic (18:1n9) and docosahexaenoic (22:6n3) acids were increased; in kidney triglycerides, the content of eicosatrionoic acid (20:3n9) and all fatty acids of the linoleic acid series was decreased, except the content of a polyunsaturated long-chain product of linoleic acid metabolism, docosapentaenoic acid (22:5n6) that was increased. These changes may have developed prenatally as a result of genetic peculiarities of SHR.
D000818:Animals; D000831:Animals, Newborn; D001095:Arachidonic Acids / Q000172:deficiency; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008041:Linoleic Acids / Q000172:deficiency; D050356:Lipid Metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D014280:Triglycerides / Q000378:metabolism
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D010743:Phospholipids; D014280:Triglycerides
Kharakteristika rannikh narusheniĭ zhirnokislotnogo sostava lipidov pochek pri spontannoĭ (nasledstvenno obuslovlennoĭ) arterial'noĭ gipertenzii.