title: Does intravenous lidocaine prevent laryngospasm after extubation in children?
abstract: One hundred otherwise healthy children undergoing tonsillectomy were investigated in a double-blind study to examine the effect of intravenous lidocaine in preventing laryngospasm upon extubation. The children were anesthetized with N2O-O2-halothane and orally intubated. They were randomly given lidocaine, 1.5 mg/kg, or saline intravenously prior to extubation, which took place at the same depth of anesthesia, namely when there were signs of swallowing activity. Eleven children (2%) in each group of 50 developed laryngospasm. From our findings it is concluded that lidocaine, 1.5 mg/kg, does not prevent laryngospasm upon extubation when extubation is carried out at the start of swallowing activity.
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007826:Laryngismus / Q000517:prevention & control*; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D014068:Tonsillectomy
chemical_list: D008012:Lidocaine