Antagonistic effect of progesterone towards estradiol dipropionate-induced changes in glycogen content in uterus and vagina of P-mice.
Estradiol dipropionate induces an increase (3-fold) in the uterine glycogen content and a decrease (4-fold) in the vaginal glycogen content of Parkes (P) mice. Progesterone antagonizes this estradiol dipropionate-induced response in both the uterine and vaginal tissue. The degree of this antagonism is more pronounced in the uterus than in the vagina.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004965:Estrogen Antagonists; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011374:Progesterone / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*; D014621:Vagina / Q000187:drug effects / Q000378:metabolism*
D004965:Estrogen Antagonists; D011374:Progesterone; D004958:Estradiol; D006003:Glycogen; C023482:estradiol dipropionate