Largomycin FII chromophore component 4, a new pluramycin antibiotic.
The chromophore of the antitumor chromoprotein largomycin FII is a mixture of components belonging to the pluramycin class of antitumor antibiotics. Against most organisms tested, component 4 exhibited activity equal to or greater than the major chromophore components pluramycin A and deacetylpluramycin A. Data obtained from UV, IR, 1H and 13C NMR, and from fast atom bombardment mass spectrometry were used to determine the structure of component 4 as epoxykidamycin, a new member of the pluramycin class.
D000617:Aminoglycosides / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002863:Chromogenic Compounds / Q000494:pharmacology*; D006020:Glycopeptides; D006023:Glycoproteins / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D013053:Spectrophotometry
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002863:Chromogenic Compounds; D006020:Glycopeptides; D006023:Glycoproteins; C032499:largomycin; C046690:epoxykidamycin