X-linked allozymes of phosphoglycerate kinase as tools in experimental carcinogenesis in the mouse.
Experimental conditions are discussed that are necessary for a useful application of genetically marked laboratory animals to distinguish between clonal and nonclonal origin of induced tumors: quantitative discrimination of biochemical markers, definition of the "patch" sizes, evaluation of possible admixture of "contaminating" cells and the approach to congenicity of parental animal strains.
D000483:Alleles; D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D051379:Mice; D010735:Phosphoglycerate Kinase / Q000235:genetics / Q000378:metabolism*; D014960:X Chromosome / Q000201:enzymology*
D007527:Isoenzymes; D010735:Phosphoglycerate Kinase