A test battery for measuring nicotine effects in mice.
A test battery consisting of measurement of respiration, startle response, Y-maze activity, heart rate, and body temperature has been developed to assess the effects of nicotine on the mouse. Results obtained using the test battery were compared to those obtained with each test individually in four inbred strains of mouse (BALB, C57BL, DBA and C3H). No significant differences between the results obtained using the test battery and those obtained with individual tests were found. The results did demonstrate, however, that the genotype of the mouse strongly influenced the responses in several of the tests.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009538:Nicotine / Q000494:pharmacology*; D013216:Reflex, Startle / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013045:Species Specificity
D009538:Nicotine