Implication of lipid peroxides in gastric ulcer formation in indomethacin-treated rats.
With the carrageenin food oedema assay, we studied in rats the effects of indomethacin on inflammation, gastric ulcers and lipid peroxide levels. Our results show a positive correlation between ulceration and plasma lipid peroxides. We suggest that the ulceration could be due to inhibition of prostacyclin synthetase by lipid peroxides.
D000818:Animals; D002351:Carrageenan; D004487:Edema; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000097:blood*; D051381:Rats; D013276:Stomach Ulcer / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors
D008054:Lipid Peroxides; D002351:Carrageenan; D007213:Indomethacin