[Brown discoid deposits in the lens following long-term administration of diazepam (Valium)].
In two patients (a married couple) the oral intake of 5 mg diazepam (Valium) per day (sometimes even more) over several years led to a homogeneous brown opacification of the lens under the anterior capsule over an area corresponding to the mean pupillary diameter. The deposit is obviously irreversible.
D000368:Aged; D002386:Cataract / Q000139:chemically induced*; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000187:drug effects; D008297:Male
D003975:Diazepam
Braune scheibenförmige Einlagerungen in die Linse nach Langzeitgabe von Diazepam (Valium).