Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents. III. Transplacental micronucleus test in mice.
The growth-promoting agents carbadox and olaquindox were active in the mouse transplacental micronucleus test, whereas cyadox was ineffective. Chemicals were administered p.o. and i.p. at a dose of 100 mg/kg and the effect was observed 18 h after treatment. The effects observed in fetal liver were parallel to those in maternal bone marrow, but fetal tissue was approximately 2-3 times more sensitive.
D000284:Administration, Oral; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002218:Carbadox / Q000008:administration & dosage / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005333:Fetus / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D011810:Quinoxalines / Q000008:administration & dosage / Q000494:pharmacology*
D011810:Quinoxalines; C020728:cyadox; C013168:olaquindox; D002218:Carbadox