title: [Ocular complications of Lyell's syndrome: recent concepts apropos of 26 cases].
abstract: Acute ocular lesions are usual during Toxic Epidermal Necrolysis (T.E.N.) and may induce persistent alterations. These were thought to be of cicatricial nature. 26 patients recovering from TEN had a systematic ophthalmological follow-up of at least six months after the acute stage (mean: 3 years). 11 of 26 patients (42%) exhibited a dry eye, associated in 7 with decreased salivary flow. The sicca syndrome appeared during the acute phase of TEN or, more often, a few weeks later. The reduction of the lacrymal flow induced corneal lesions in all 11 patients and 6 patients suffered permanent visual impairment. Biopsies of labial accessory salivary glands showed a lymphocytic infiltration of the glandular tissue in 5 of 7 cases. In 2 cases the lymphocytic infiltrate was nodular, grade III of Chisholm's classification, considered as pathognomonic of Sjogren's syndrome. The occurrence of Sjogren-like syndrome in patients recovering from TEN suggests an auto-immune pathogenesis for TEN, and is one more analogy between TEN and graft-versus-host disease.
mesh_terms: D003229:Conjunctival Diseases / Q000209:etiology; D003318:Corneal Opacity / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology*; D005141:Eyelid Diseases / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007634:Keratitis / Q000209:etiology; D008214:Lymphocytes / Q000473:pathology; D012470:Salivary Glands, Minor / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D000267:Tissue Adhesions / Q000209:etiology; D014985:Xerophthalmia / Q000209:etiology
vernacular_title: Les complications oculaires du syndrome de Lyell: notions récentes à propos de 26 cas.