M-7 lowers rabbit intraocular pressure.
Changes in intraocular pressure (IOP) and pupil diameter were studied in albino rabbits following topical administration of TL-99, M-7 (N,N-dimethyl analogues of 2-aminotetralin), DiPr-5,6-ADTN, DiPr-6,7-ADTN (dipropyl analogues of aminotetralin) and DPDA (N,N-di-n-propyl-dopamine), known as mixed alpha-adrenoceptor/dopamine receptor agonists with variable alpha 1/alpha 2-adrenoceptor/selectivity. The potencies of those compounds to decrease IOP were compared with each other. We found that M-7 has the most potent IOP-lowering properties, caused minimal ocular discomfort and is of interest as a potential antiglaucoma agent. The ocular hypotension was completely inhibited by rauwolscine and slightly antagonized by various other blocking agents. The results strongly suggest that the IOP-lowering effect of M-7 is mediated by the stimulation of alpha 2-adrenoceptors.
D000818:Animals; D003864:Depression, Chemical; D004298:Dopamine / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009284:Naphthols / Q000494:pharmacology*; D011817:Rabbits; D013565:Sympatholytics / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D009284:Naphthols; D013565:Sympatholytics; D013764:Tetrahydronaphthalenes; C009957:5,6-dihydroxy-2-dimethylaminotetralin; C015842:2-(N,N-dipropyl)amino-5,6-dihydroxytetralin; C037253:2-(N,N-dipropyl)amino-6,7-dihydroxytetralin; C020895:N,N-di-n-propyldopamine; C016893:2-(N,N-dimethylamino)-6,7-dihydroxytetralin; D004298:Dopamine