Mosaic Turner's syndrome and pituitary microadenoma.
A case of a 25-year-old woman with amenorrhoea-galactorrhoea syndrome and microprolactinoma is reported. The 45 XO/46 XX chromosome aberration did not cause complete ovarian failure. The presence of a pituitary microadenoma was demonstrated by thin layer pluridirectional x-ray tomography of the sella and the pathologically high prolactin reserve capacity of the pituitary. After the removal of the microprolactinoma and postoperative bromocriptine administration, regular menstrual bleeding occurred and the galactorrhoea disappeared. Some possible explanations of peripheral endocrine gland disorders accompanied by pituitary adenomas are discussed.
D000236:Adenoma / Q000097:blood / Q000150:complications* / Q000601:surgery; D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009030:Mosaicism; D010908:Pituitary Hormones, Anterior / Q000097:blood; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications*; D011388:Prolactin / Q000097:blood; D014424:Turner Syndrome / Q000097:blood / Q000150:complications* / Q000235:genetics
D010908:Pituitary Hormones, Anterior; D001971:Bromocriptine; D011388:Prolactin