Uneventful plasma exchange with albumin replacement in a patient with a previous anaphylactoid reaction to albumin.
A patient who had a previous anaphylactoid reaction to albumin required plasma exchange for myasthenia gravis. She was rechallenged with albumin from a different manufacturer after premedication with diphenhydramine. No adverse reaction occurred during five exchanges over a 10-day period. Possible pathogenic mechanisms and prevention of such reactions are discussed.
D000368:Aged; D000707:Anaphylaxis / Q000209:etiology / Q000628:therapy*; D004155:Diphenhydramine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000628:therapy; D010951:Plasma Exchange / Q000009:adverse effects; D011292:Premedication; D012709:Serum Albumin / Q000008:administration & dosage* / Q000009:adverse effects
D012709:Serum Albumin; D004155:Diphenhydramine