Contraction and relaxation of rabbit basilar artery by thiopental.
Tension measurements were made on rabbit basilar artery segments to test the direct effect of thiopental on serotonin (5HT)- and norepinephrine (NE)-induced contraction. At concentrations of 3 X 10(-5) M or greater, thiopental caused relaxation of NE-induced tension. Thiopental doses greater than 3 X 10(-4) M had a similar relaxing effect on 5HT-induced contraction. However, thiopental doses below 3 X 10(-4) M demonstrated an unexpected dose-dependent potentiation of the 5HT-induced contraction.
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D012701:Serotonin; D013874:Thiopental; D009638:Norepinephrine