In vivo alteration of RES phagocytosis by magnetic albumin microspheres.
The effect of non-localized magnetically responsive albumin microspheres (MR-AMS) on RES phagocytic function was investigated. MR-AMS and MR-AMS containing Adriamycin (MR-AMS-ADR) were injected intravenously in rats at a dose which saturated all RES phagocytes. The ability of the RES to clear the bloodstream of a subsequent suspension of MR-AMS or streptococci was then analyzed over a three day period. MR-AMS clearance was enhanced after initial RES saturation with MR-AMS but depressed when the saturating agent was MR-AMS-ADR. Bloodstream clearance of streptococci was depressed by MR-AMS and MR-AMS-ADR. Localization of MR-AMS in the RES might depress RES phagocytosis by physical saturation of phagocytes or by a direct toxic effect of encapsulated chemotherapeutic agents.
D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes; D007700:Kinetics; D008280:Magnetics; D008863:Microspheres; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D010587:Phagocytosis; D051381:Rats; D011916:Rats, Inbred F344; D012710:Serum Albumin, Bovine
D007457:Iodine Radioisotopes; D012710:Serum Albumin, Bovine