Autoradiographic visualization of extrajunctional acetylcholine receptors in whole human biceps brachii muscle. Changes in amyotrophic lateral sclerosis.
The morphological distribution of acetylcholine receptors in the whole biceps brachii muscle from a patient with amyotrophic lateral sclerosis (ALS) and from a control patient was studied by in vitro autoradiography with 3H-alpha-bungarotoxin (alpha-Btx). In ALS, 3H-alpha-Btx binding occurred over the entire muscle, while in the control case the binding was restricted to the motor end-plate region.
D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001345:Autoradiography; D002038:Bungarotoxins / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*
D002038:Bungarotoxins; D011950:Receptors, Cholinergic