Isolation and characterization of a possible new protein marker for differential diagnosis between metastatic carcinoma and mesothelioma cells in serous effusions: preliminary findings.
A distinctive diagnostic staining pattern of the cytoplasm of reactive and neoplastic mesothelial cells in serous effusions was assumed to be caused by a specific compound. This was isolated by polyacrylamide gel electrophoresis and corresponded to a protein with an apparent molecular weight around 200,000. Isoelectric point was found to be 8.7. This protein contained high proportions of glutamic acid, serine, and glycine.
D001202:Ascitic Fluid / Q000473:pathology*; D003937:Diagnosis, Differential; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007525:Isoelectric Focusing; D008654:Mesothelioma / Q000032:analysis / Q000175:diagnosis* / Q000473:pathology; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis*; D010996:Pleural Effusion / Q000473:pathology*
D009363:Neoplasm Proteins