[Localization of the primary action of amino acids leading to the stimulation of gastric secretion].
An attempt has been made to specify whether the stimulant action of amino acids on gastric secretion is related to their direct effect on the structures of the central nervous system or to the influence on certain peripheral receptor formations followed by information transmission to the nervous centres. Acute experiments on dogs were performed to compare the effect of amino acids injected to the carotid artery and to the peripheral vein. It was established that amino acids injected to the carotid artery produced a more rapidly developing and more pronounced secretory reaction of the gastric glands than amino acids injected to the peripheral vein. This fact may strongly indicate that the above effect of amino acids is linked with their direct action on brain structures.
D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D013268:Stimulation, Chemical; D013997:Time Factors
D000596:Amino Acids
O lokalizatsii pervichnogo deĭstviia aminokislot, privodiashchego k vozbuzhdeniiu zheludochnoĭ sekretsii.