AA-amyloidosis in dogs: partial amino acid sequence of protein AA and immunohistochemical cross-reactivity with human and cow AA-amyloid.
Protein AA was purified from the kidneys of dogs with spontaneous reactive amyloidosis. The protein had a blocked N-terminal. Sequence analysis of a peptide obtained after cyanogen bromide cleavage revealed an amino acid sequence corresponding to positions 24-42 of human AA. This region showed a strong homology to protein AA of other species. Antiserum to both human and dog protein AA reacted immunohistochemically with AA amyloid of human, dog and cow origin.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000302:isolation & purification*; D000686:Amyloidosis / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism* / Q000473:pathology; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D000685:Serum Amyloid A Protein / Q000302:isolation & purification*; D013045:Species Specificity
D000682:Amyloid; D000685:Serum Amyloid A Protein