Synthesis, tissue distribution and tumor uptake of 99mTc- and 67Ga-tetrasulfophthalocyanine.
Complexes of tetrasulfophthalocyanine with 99mTc, 69Ga and 67Ga were prepared by the condensation of sulfophthalic acid with the appropriate metal-species. The Ga-complex was also obtained by exchange of the central hydrogens of the empty tetrasulfophthalocyanine. The labeled complexes were purified by thin layer chromatography and characterized by their chromatographic properties. Their biodistribution in rabbits and tumor-bearing rats revealed that most of the radioactivity accumulated in the kidneys, liver, ovaries, adrenals and spleen. Comparison of these distribution pattern with those of [99mTc]pertechnetate and 67Ga-citrate confirmed the in vivo stability of the labeled complexes. The 67Ga-complex reached better tumor-to-blood and tumor-to-muscle ratios than 67Ga-citrate.
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D000818:Animals; D005260:Female; D005710:Gallium Radioisotopes; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis / Q000378:metabolism*; D007700:Kinetics; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D013667:Technetium / Q000378:metabolism*; D014018:Tissue Distribution
D005710:Gallium Radioisotopes; D007202:Indicators and Reagents; D007211:Indoles; D015609:Organotechnetium Compounds; C049167:technetium Tc 99m tetrasulfophthalocyanine; C028418:tetrasulfophthalocyanine; D013667:Technetium