An approach using lecithin treatment for olivopontocerebellar atrophies.
A therapeutic trial with two different lecithins, with 32 and 7% phosphatidylcholine respectively, was performed for 3 months on 11 patients with clinical diagnosis of dominant, recessive and sporadic olivopontocerebellar atrophies. The correlation between plasma choline levels and the clinical picture shows a clinical worsening with very high choline levels and a slight improvement with smaller increases of plasma choline levels. The possible role in these disorders of phosphatidylcholine and linoleic acid - both present in lecithin - is discussed, with relationship to these findings.
D000328:Adult; D002524:Cerebellar Ataxia / Q000188:drug therapy* / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D002794:Choline / Q000097:blood; D003391:Cranial Nerves / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D011712:Pyramidal Tracts / Q000503:physiopathology; D013577:Syndrome; D014057:Tomography, X-Ray Computed
D008076:Cholesterol, HDL; D010713:Phosphatidylcholines; D002794:Choline