title: [Effect of treatment with synthetic eel-calcitonin derivative in patients suffering pain due to bone metastases].
abstract: Synthetic Calcitonin Derivative obtained from eel (eel-calcitonin) was given to 15 patients suffering from pain due to bone metastases of malignant tumors. The analgesic effect of synthetic eel-calcitonin derivative was evaluated through pain and narcotic score with the Ridit method. With regard to pain score, significant analgesic effect was observed in the first week (p less than 0.001), and after a month there was also a decrease in the narcotic score (p less than 0.05). However, changes in serum Ca, P, ALP values, and the findings of bone scintigrams and roentgenography, rarely occurred following the treatment. The toxicities of eel-calcitonin which were observed in this series were as follows; nausea and vomiting (33%), flush (11%), eruption (6%). These findings suggest that synthetic eel-calcitonin derivative is a very useful agent for pain due to bone metastases.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002116:Calcitonin / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004524:Eels; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009619:Nociceptors / Q000187:drug effects; D010148:Intractable Pain / Q000188:drug therapy*; D011877:Radionuclide Imaging; D014839:Vomiting / Q000139:chemically induced
chemical_list: D002116:Calcitonin