Induced rewarming by central stimulation in hypothermic hamsters.
Helium-cold hypothermic hamsters, colonic temperature (Tc) 7 to 11 degrees C, injected with acetylcholine (ACH) at a preoptic-anterior hypothalamic (AHPOA) site responded with a rise in colonic temperature while remaining in a cold environmental chamber. The He-Cold hamster does not thermoregulate at these body temperatures. In contrast to central ACH-elicited responses, the injection of alpha and beta adrenergic drugs into the systemic circulation of the He-Cold hamster did not elicit a rise in colonic temperature. The data describe a different animal model of rewarming than has previously been described that is under pharmacologic control by the experimenter. The use of exogenous neurotransmitter provides the potential to understand the mechanisms of thermoregulation in deep experimental hypothermia.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000187:drug effects / Q000503:physiopathology*; D001831:Body Temperature / Q000187:drug effects*; D006224:Cricetinae; D006371:Helium; D007035:Hypothermia / Q000503:physiopathology*; D007700:Kinetics; D008647:Mesocricetus; D011301:Preoptic Area / Q000187:drug effects / Q000503:physiopathology*
D006371:Helium; D000109:Acetylcholine