Cytogenetic analysis of peripheral blood lymphocytes in glass workers occupationally exposed to mineral oils.
Chromosome aberration tests were carried out in a group of 31 pressed glass makers operating an automatic line of press-and-blow machines known to release mineral oil mists containing relatively high concentrations of the mutagenic chemicals belonging to a class of polycyclic aromatic hydrocarbons (PAH). The workers were exposed to the mineral oil aerosol levels that did not exceed the Czechoslovak maximum allowable concentration limit of 5 mg . m-1 of air. The tests revealed that the frequency of aberrant cells (% AB.C.) and the value of breaks per cell (B/C) ratio found in mineral oil-exposed workers were increased significantly, accounting for 4.65 +/- 0.29% AB.C. (0.0532 B/C) vs. 1.13 +/- 0.19% AB.C. (0.0113 B/C) seen in matching controls. Also, a higher rate of dicentrics, reciprocal translocations and cells with pulverization was observed in this group of glass workers. These finding are considered as evidence suggesting that these workers might experience an increased risk of genetic injury due to exposure to mineral oil mists.
D000328:Adult; D000336:Aerosols; D002869:Chromosome Aberrations; D005898:Glass; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008899:Mineral Oil / Q000009:adverse effects*; D009784:Occupational Diseases / Q000209:etiology*; D011083:Polycyclic Compounds / Q000633:toxicity; D012907:Smoking
D000336:Aerosols; D011083:Polycyclic Compounds; D008899:Mineral Oil