Digoxin toxicity in a premature infant: treatment with Fab fragments of digoxin-specific antibodies.
The first use of Fab fragments to treat digoxin toxicity in a premature infant with renal failure, 18 h after the onset of severe arrhythmias, is reported with dramatic results. The development of digoxin toxicity in the context of accepted therapeutic dosing to treat heart failure due to a cerebral arteriovenous malformation is discussed.
D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000628:therapy*; D004077:Digoxin / Q000009:adverse effects* / Q000276:immunology; D012734:Disorders of Sex Development / Q000150:complications; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced / Q000628:therapy*
D007140:Immunoglobulin Fab Fragments; D004077:Digoxin