Caffeine-induced taste aversion and mimetic responses.
Novel tastes preceded a range of caffeine doses (10-80 mg/kg) in a taste aversion training trial. One week later rats which had doses of 30 mg or higher showed strong aversions as measured by a single bottle consumption test. The 10 and 20 mg dose produced the most hyperactivity and apparently enhanced intake of the taste paired with caffeine. During the training trial, rats receiving the 80 mg dose exhibited copious gapes and chin-rubs, mimetic responses to noxious tastes. Gapes also occurred in these subjects during the aversion test. Consumption was more sensitive than mimetic responding as a measure of the aversive effects of caffeine. Only the 80 mg dose produced neophobia. Tests with isotonic injections indicated that tonicity was not the source of the aversions.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013649:Taste / Q000187:drug effects*; D013997:Time Factors
D002110:Caffeine