Necrobiotic xanthogranuloma: a systemic disease with paraproteinemia.
A woman of 39 presenting with a conjunctival swelling with a necrobiotic xanthogranulomatous histology suffered from a series of destructive cutaneous lesions of similar histology for 20 yr. She had a paraproteinemia and developed myelomatosis. At postmortem xanthogranulomatous lesions were found in skin, larynx, heart and kidneys. The patient also had nodular transformation of the liver with portal hypertension.
D000328:Adult; D001158:Arteries / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*; D012871:Skin Diseases / Q000150:complications / Q000473:pathology*