title: [Isolation and characteristics of peptide fractions from the rat brain in ischemia].
abstract: The low-molecular peptide fractions are obtained from the brain of experimental and control animals by the method which includes sedimentation of high-molecular compounds and gel-filtration on Sephadex G-10. Ischemia of the rat brain sharply changes the amino acidic composition of the isolated peptide fractions. An inhibitory effect of the studied fractions on the activity of DNA-dependent RNA polymerase as well as their effect on the heat denaturation of exogenous DNA are established.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002850:Chromatography, Gel; D004247:DNA / Q000032:analysis; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D051381:Rats
chemical_list: D009419:Nerve Tissue Proteins; D004247:DNA; D012321:DNA-Directed RNA Polymerases
vernacular_title: Vydelenie i kharakteristika fraktsiĭ peptidov iz mozga krys pri ishemii.