Astrocytes support incomplete differentiation of an oligodendrocyte precursor cell.
Glial fibrillary acidic protein-positive astrocytes, but not neurons or fibroblasts, support the differentiation of an oligodendroglial precursor cell expressing O4 antigen and vimentin into an O4 antigen-positive, but vimentin-negative oligodendrocyte. Further maturation into galactocerebroside (O1)-positive oligodendrocytes is, however, not achieved under the culture conditions used, neither in the presence of astrocytes nor neurons.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D001253:Astrocytes / Q000166:cytology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D008854:Microscopy, Electron; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology; D009836:Oligodendroglia / Q000166:cytology*; D051381:Rats; D014746:Vimentin / Q000378:metabolism
D000954:Antigens, Surface; D014746:Vimentin