title: Blood pressure and heart rate responses to environmental stress in the spontaneously hypertensive rat.
abstract: Blood pressure and heart rate responses of the spontaneously hypertensive rat (SHR) and the Wistar-Kyoto rat (WKY) to mild restraint and tone-shock pairings were compared during a pre-stress, aversive conditioning and post-stress period, after five previous days of exposure to the paradigm. Although SHR and WKY showed similar responses to the onset of the pre-stress period, SHR showed significantly larger blood pressure responses following the onset of the conditioning than WKY. Furthermore, WKY showed a significant blood pressure and heart rate reduction during the conditioning session which was absent in the SHR. During the post-stress period, the blood pressure of SHR remained significantly elevated compared to their home cage rest values, but the blood pressure of WKY returned to basal levels. It is concluded that while the SHR is more reactive than the WKY to stimulus onset, the major source of between-strain differences after 20 min relates to differences in adaptation to continued environmental stimulation. This can lead to exaggerated estimates of physiological reactivity of the SHR, and is supportive of Folkow's view that SHR are both hyperreactive and show more prolonged defense reactions.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003214:Conditioning, Classical / Q000502:physiology; D004597:Electroshock; D006339:Heart Rate; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013016:Sound; D013045:Species Specificity; D013312:Stress, Physiological / Q000503:physiopathology*