title: [The stability of hydrochlorothiazide and cyclopenthiazide in various drug forms. 2. The stability of Disalunil tablets].
abstract: Checking-up the stability of hydrochlorothiazid tablets (Disalunil), chemical and especially pharmaceutical-technological analyses were forming part of the adequate test programme. The pharmaceutical and chemical properties of the Disalunil tablets will be regarded as sufficient ones at normal conditions of their storage. In case the tablets will be stored, however, in their original packing under conditions of an increased humidity or with additional water, the water sorption will result in prolonged disintegration rates as well as in a reduced radial breaking strength and dissolution rate. This significant depreciation of the drug cannot be recognized by chemical-analytical methods.
mesh_terms: D003518:Cyclopenthiazide / Q000032:analysis*; D004232:Diuretics; D004355:Drug Stability; D006852:Hydrochlorothiazide / Q000032:analysis*; D049993:Sodium Chloride Symporter Inhibitors / Q000032:analysis*; D013607:Tablets; D013997:Time Factors
chemical_list: D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D013607:Tablets; D006852:Hydrochlorothiazide; D003518:Cyclopenthiazide
vernacular_title: Untersuchungen zur Stabilität von Hydrochlorothiazid und Cyclopenthiazid in unterschiedlichen Arzneiformen. 2. Mitteilung: Stabilität von Disalunil-Tabletten.