title: Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline).
abstract: All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over the test period.
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004435:Eating / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; D010879:Piperazines; D001839:Bombesin; C015924:histidyl-proline diketopiperazine