Suppression of cholesterogenesis by plant constituents: review of Wisconsin contributions to NC-167.
In animals, non-sterol metabolites of the mevalonate pathway act independently from receptor-mediated cholesterol uptake in the multivalent feedback regulation of mevalonate biosynthesis. Studies leading to the isolation and characterization of plant-borne suppressors of mevalonate biosynthesis are reviewed. We propose that one cardio-protective component of the vegetarian diet consists of a variety of non-sterol, post-mevalonate metabolites. These products of plant branches of the mevalonate pathway, discarded as animals evolved, continue to influence animal sterol metabolism. It is through this action, we propose, that the cholesterol-suppressive action of plant materials is expressed.
D000818:Animals; D002645:Chickens; D002784:Cholesterol / Q000096:biosynthesis*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D004032:Diet; D002523:Edible Grain; D064429:Fatty Acid Synthases / Q000378:metabolism; D005246:Feedback; D001467:Hordeum; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008798:Mevalonic Acid / Q000096:biosynthesis; D008862:Microsomes, Liver / Q000201:enzymology; D012434:Secale; D003313:Zea mays
D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D002790:Cholesterol 7-alpha-Hydroxylase; D064429:Fatty Acid Synthases; D008798:Mevalonic Acid