Breast cancer in women under 30 years of age.
Conflicting opinions exist concerning clinical and pathological presentation, as well as evolution and prognosis, of breast cancer in young women. The roles of associated pregnancy and lactation on these parameters is also unclear. These two conditions are studied in the present work through the comparison of two breast cancer patient age groups: patients under the age of 30 (Group A) and premenopausal patients aged 45-49 (Group B). Rapidly growing and/or inflammatory breast cancer (rapidly progressing breast cancer: RPBC)--a special form of Breast Cancer with a poor prognosis very frequent in the Tunisian breast cancer population--was more often present among Group A patients. This difference is a consequence of the more frequent association of this breast cancer group with pregnancy or lactation; nearly all the cases of breast cancer associated with pregnancy or lactation are RPBC. For breast cancer without the pregnancy/lactation association, the younger group generally shows poorer histological grading and more severe evolution. The number of patients in our study is not really sufficient to allow statistically significant conclusions, but it does seem clear that young age and associated pregnancy/lactation are aggravating factors in Tunisian breast cancer patients.
D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000150:complications / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000556:secondary; D005260:Female; D006801:Humans; D007774:Lactation; D008593:Menopause; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011379:Prognosis; D012189:Retrospective Studies; D014416:Tunisia