[Study of the growth of Streptomyces rimosus cultures during controlled biosynthesis of oxytetracycline using differential sucrose density gradient centrifugation].
The developmental characteristics of the oxytetracycline-producing organism were studied with differential centrifuging over the sucrose density gradient. It was shown that the fermentation broth of Streptomyces rimosus is divided into 7 mycelial fractions and only 2 of them are capable of biosynthesis of oxytetracycline. During controlled biosynthesis of oxytetracycline the mycelium content in these fractions was higher.
D002499:Centrifugation, Density Gradient; D003470:Culture Media; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces / Q000254:growth & development*
D003470:Culture Media; D010118:Oxytetracycline
Izuchenie razvitiia kul'tury Streptomyces rimosus v protsesse reguliruemogo biosinteza oksitetratsiklina metodom differentsial'nogo tsentrifugirovaniia v gradiente plotnosti sakharozy.