Depressed interferon synthesis in skin fibroblasts from lung cancer patients.
Skin fibroblast cell cultures, derived from male adult lung cancer patients, an adult control population, and a newborn population were examined for their susceptibility to transformation with Kirsten murine sarcoma virus and their ability to respond to an interferon inducer (poly I X poly C). An association between sensitivity to viral transformation and induction of interferon was observed. Cultures derived from lung cancer patients demonstrated an increased sensitivity to virus transformation and a decreased ability to respond to interferon induction as compared with age-matched controls and newborns.
D000328:Adult; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D007668:Kidney; D007708:Kirsten murine sarcoma virus / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D008297:Male; D011070:Poly I-C / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000276:immunology*
D007370:Interferon Type I; D011070:Poly I-C