Effect of sodium fluoride on cholinesterase activity in postmortem blood.
Thirty-two postmortem blood specimens, with and without sodium fluoride as preservative, were analyzed for cholinesterase activity by the Michel method. The fluoridated specimens, which contained from 0.7 to 31 mg/mL (average 6.3) of sodium fluoride, were found to exhibit cholinesterase activities that were 5 to 59% (average 25%) lower than the duplicate unfluoridated specimens. We concluded that, while this decrease is quite significant, a fluoridated postmortem blood specimen may be used for the measurement of cholinesterase activity when a non-fluoridated specimen is unavailable.
D000110:Acetylcholinesterase / Q000097:blood*; D001793:Blood Preservation; D002800:Cholinesterase Inhibitors; D006801:Humans; D012969:Sodium Fluoride / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D012969:Sodium Fluoride; D000110:Acetylcholinesterase