Activity of selenazofurin against influenza A and B viruses in vitro.
Activity of the new antiviral compound selenazofurin was compared with the known active compounds ribavirin and amantadine against influenza A and B viruses. In experiments with Madin Darby canine kidney cells, selenazofurin inhibited the cytopathic effect and yield of influenza A/NWS/33 virus, with 50% effective dose ranges of 0.7 to 1.4 micrograms/ml (virus rating [VR], 1.3 to 1.4). The 50% effective dose range for ribavirin was 1.2 to 1.6 micrograms/ml (VR, 1.0 to 1.3), and for amantadine it was 9 micrograms/ml (VR, 0.9). Selenazofurin and ribavirin were similarly inhibitory to influenza B/Lee/40 virus, whereas amantadine was inactive. Selenazofurin appeared somewhat cytotoxic in these studies at concentrations as low as 1 micrograms/ml.
D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D066298:In Vitro Techniques; D009980:Influenza A virus / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects*; D016566:Organoselenium Compounds; D012254:Ribavirin / Q000494:pharmacology / Q000031:analogs & derivatives; D012263:Ribonucleosides / Q000494:pharmacology*; D012643:Selenium / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
D016566:Organoselenium Compounds; D012263:Ribonucleosides; D012254:Ribavirin; D000547:Amantadine; D012643:Selenium; C039064:selenazofurin