title: [Behavior of chloramphenicol residues following intramuscular administration in swine].
abstract: Residues of chloramphenicol (CAP) were examined in 24 pigs after intramuscular injection of 30 mg CAP/kg body weight. Two pigs were slaughtered after 3, 6, 12, 18, 24, 36 hours, 2, 3, 6, 10, 21 and 30 days, respectively. CAP-concentrations were determined in muscle, blood, urine, liver, kidney, bile, and fat. Methods used were gas-liquid chromatography and radioimmunoassay. Detection limits reached were 1-5 ppb. The concentration-time curves obtained reflected a long elimination phase and allowed only calculation of this half-life. Elimination half-life was estimated to be for muscle, blood and urine 160-170 hours, for kidney 310 and for bile 250 hours. Significant correlations were found to exist between CAP-concentrations in plasma and muscle. It appears that blood would be a good body fluid for monitoring CAP-residues in tissue.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001826:Body Fluids / Q000378:metabolism; D002701:Chloramphenicol / Q000008:administration & dosage / Q000378:metabolism*; D002849:Chromatography, Gas; D007273:Injections, Intramuscular / Q000662:veterinary; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D011863:Radioimmunoassay / Q000662:veterinary; D013552:Swine / Q000378:metabolism*; D013997:Time Factors
chemical_list: D002701:Chloramphenicol
vernacular_title: Das Rückstandsverhalten von Chloramphenicol nach intramuskulärer Applikation beim Schwein.