title: In vivo mutagenicity evaluation of domperidone in Drosophila germ cells and rat bone marrow cells.
abstract: Possible induction of chromosome aberrations and gene mutations by domperidone was studied in vivo respectively by a micronucleus test on female rats and a sex-linked recessive lethal test on Drosophila. In accordance with previous results all these studies revealed negative findings for domperidone so that it can be concluded that domperidone has no potential to induce chromosome aberrations and/or gene mutations.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004294:Domperidone / Q000633:toxicity*; D004330:Drosophila; D005260:Female; D005854:Germ Cells / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D009153:Mutagens; D004294:Domperidone