title: Thiopental requirements may be increased in children reanesthetized at least one year after recovery from extensive thermal injury.
abstract: Clinical observations suggested that children long recovered from burn injury required larger doses of thiopental for a smooth anesthetic induction. A prospective randomized study examined children 6-16 yr old, with greater than 15% burn, and more than 1 year after injury, for loss of lid reflex (LR), corneal reflex (CR), and acceptance of the anesthesia mask (AM) 60 sec after administration of thiopental. Children were unpremedicated, received the thiopental (2.5%) through a rapidly running peripheral intravenous line, and received either 2, 3, 4, 5, 6, 7, or 8 mg/kg. LR, CR, and AM were examined at 30, 60, and 90 sec. Blood pressure and heart rate were recorded for those patients receiving 7 or 8 mg/kg thiopental. The mean age was 12.0 +/- 0.5 yr, weight 43.9 +/- 2.9 kg, % burn 44.7 +/- 2.9, time since burn 68.4 +/- 7.7 months, and time since previous thiopental 25.1 +/- 6.6 months. The estimated ED50 (95% confidence limits) for loss of LR was 4.78 (3.95-5.78) mg/kg; for loss of CR was 7.04 (4.87-10.10) mg/kg; and for AM was 6.74 (4.68-9.71) mg/kg. These doses of thiopental were significantly greater for LR and AM (P less than 0.001) but not CR (P = 0.15) compared to non-thermally injured children. There were no clinically important or statistically significant decreases in blood pressure while heart rate did increase 11 beats/min (P less than 0.05) in children who received 7 or 8 mg/kg.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000293:Adolescent; D000758:Anesthesia; D001767:Blinking / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002056:Burns / Q000503:physiopathology*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005143:Eyelids / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011446:Prospective Studies; D011897:Random Allocation; D012018:Reflex / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D013874:Thiopental