[Role of phospholipids in changes in lysosomal membrane stability in conditions of chronic alcoholic intoxication].
Pronounced destabilization of liver lysosomal membranes has been revealed in rats in conditions of 30-day-long alcohol intoxication. Noticeable fractional changes in phospholipid composition of lysosomal membranes have been found. Significant increase in lysophosphatidylethanolamine and lysophosphatidylcholine levels have been observed. Type A2 phospholipase activity was found in lysosomal fractions, with the enzyme activity Ca2+-dependent, optimal at pH 8 and increasing many-fold following alcohol intoxication. The changes in lysosomal membrane phospholipids appear to be related to phospholipase A2 activation.
D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D007425:Intracellular Membranes / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008247:Lysosomes / Q000473:pathology*; D008297:Male; D010743:Phospholipids / Q000502:physiology*; D051381:Rats
D010743:Phospholipids
Rol' fosfolipidov v izmenenii stabil'nosti lizosomal'nykh membran v usloviiakh khronicheskoĭ alkogol'noĭ intoksikatsii.