Prune belly syndrome and heart defect in one of monozygotic twins, following exposure to Tigan and Bendectin.
One of twins was born with prune belly syndrome and congenital heart defect following exposure to Bendectin and Tigan. Red cell antigens and HLA typing were compatible with monozygosity. The possible associations of the prune belly syndrome to monozygotic twinning or to teratogenic agents is considered in light of this patient and review of the literature.
D001549:Benzamides / Q000009:adverse effects*; D004025:Dicyclomine; D004319:Doxylamine / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D006330:Heart Defects, Congenital / Q000139:chemically induced* / Q000235:genetics; D006801:Humans; D011535:Prune Belly Syndrome / Q000139:chemically induced* / Q000235:genetics; D011725:Pyridines / Q000009:adverse effects*; D011736:Pyridoxine / Q000009:adverse effects*; D014427:Twins; D014430:Twins, Monozygotic
D001549:Benzamides; D004338:Drug Combinations; D011725:Pyridines; C004454:dicyclomine, doxylamine, pyridoxine drug combination; D004025:Dicyclomine; D004319:Doxylamine; D011736:Pyridoxine; C100146:trimethobenzamide