[Ostium stenosis of both coronary arteries and latent hypothyroidism as sequelae of radiotherapy in Hodgkin disease].
Premature arteriosclerosis following irradiation is a known experimental and clinical phenomenon. Although the heart was once considered a relatively radioresistant organ, now all components, including the coronary arteries, are recognised as possible targets of radiation injury. We present a 40-year-old women who received extensive neck and thoracic radiation for treatment of Hodgkin's disease. Ten years later she developed severe coronary artery disease with ostium stenosis of the left and right coronary arteries, as well as subclinical hypothyroidism.
D000328:Adult; D000787:Angina Pectoris / Q000209:etiology; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D003331:Coronary Vessels / Q000528:radiation effects*; D004562:Electrocardiography; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology*; D011867:Radioisotope Teletherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D013961:Thyroid Gland / Q000528:radiation effects*
D003037:Cobalt Radioisotopes
Ostiumstenose beider Koronararterien und latente Hypothyreose als Folge der Strahlentherapie bei Morbus Hodgkin.