[Frequency of lethal congenital malformations. Experience supported by 600 autopsies].
Data analysis of 600 neonatal necropsies performed in our Center from 1978 to 1984, has shown that in 200 cases one or more lethal malformations were observed: the most frequent concerned the central nervous system (33 cases), the urinary tract system (28 cases) and the cardiovascular system (26 cases). A genetic determinism was considered in 127 cases (63,5%). Usually a genetic counselling follows neonatal death in our Center: necropsy findings are then most useful: the authors advocate the interest of a close collaboration between pathologists and geneticists.
D001344:Autopsy; D002869:Chromosome Aberrations / Q000401:mortality; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000453:epidemiology / Q000235:genetics / Q000401:mortality*; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D005602:France; D005817:Genetic Counseling; D006801:Humans; D011247:Pregnancy
La fréquence des malformations précocement létales. Expérience portant sur 600 autopsies.