title: Improved free energies for G.C base-pairs.
abstract: Thermodynamic parameters of helix formation are reported for seven oligoribonucleotides containing only G.C pairs. These data are used with the nearest-neighbor model to calculate enthalpies and free energies of base-pair formation for G.C pairs. For helix initiation, the free energy change at 37 degrees C, delta G(0)37, is +3.9 kcal/mol; for helix propagation, the delta G(0)37 values are -2.3, -3.2 and -3.3 kcal/mol for C-G, G-G and G-C neighbors, respectively.
mesh_terms: D001482:Base Composition; D003596:Cytosine; D006147:Guanine; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides; D013816:Thermodynamics
chemical_list: D009843:Oligoribonucleotides; D006147:Guanine; D003596:Cytosine