A comparison of alpha 2-adrenoceptor regulation in brain and platelets.
Functional responses and alpha 2-adrenoceptor radioligand binding were studied in brain and platelets of rabbits under a variety of circumstances. The effects of oestrogen treatment and maturation were studied in female rabbits and of aging and amitriptyline treatment in male rabbits. No correlation was found between changes in brain and platelets either in response or alpha 2-adrenoceptor ligand binding under any of the conditions examined.
D000375:Aging; D000639:Amitriptyline / Q000008:administration & dosage; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003000:Clonidine / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D011941:Receptors, Adrenergic / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors
D011941:Receptors, Adrenergic; D000639:Amitriptyline; D004958:Estradiol; D003000:Clonidine