E-17 alpha-(2-[125I]iodovinyl)-19-nortestosterone: the synthesis of a gamma-emitting ligand for the progesterone receptor.
We have synthesized a gamma-emitting steroid, E-17 alpha-(2-[125I]iodovinyl)-19-nortestosterone (E-IVNT), which is a useful ligand for the sensitive and accurate assay of the progesterone receptor. The synthetic scheme is rapid and is performed with readily available materials. This compound, [125I]E-IVNT, is stable and binds with high affinity to the progesterone receptor.
D000345:Affinity Labels / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D005260:Female; D007457:Iodine Radioisotopes / Q000378:metabolism; D007700:Kinetics; D008722:Methods; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D011397:Promegestone / Q000378:metabolism; D011817:Rabbits; D011980:Receptors, Progesterone / Q000378:metabolism*
D000345:Affinity Labels; D007457:Iodine Radioisotopes; D011980:Receptors, Progesterone; D009277:Nandrolone; C049157:(2-iodovinyl)-19-nortestosterone; D011397:Promegestone