Synthesis of 15O-labeled butanol via organoborane chemistry.
Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O2-15O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.
D001880:Boranes; D000440:Butanols; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D010103:Oxygen Isotopes
D001880:Boranes; D000440:Butanols; D007202:Indicators and Reagents; D010103:Oxygen Isotopes