The effect of 1 alpha-hydroxyvitamin D2 on calcium metabolism in glucocorticoid-treated rats.
Intestinal calcium transport and renal calcium and phosphate excretion have been measured in normal and prednisolone-treated rats. Prednisolone treatment reduced intestinal calcium transport and increased phosphate excretion, causing a reduction in serum phosphate. Both 1 alpha-hydroxyvitamin D2 and 1 alpha-hydroxyvitamin D3 normalized phosphate excretion, whereas 1 alpha-hydroxyvitamin D3 was not fully effective in serum phosphate. Prednisolone treatment also caused a decreased bone density that was prevented both with 1 alpha-hydroxyvitamin D2 and 1 alpha-hydroxyvitamin D3. 1 alpha-hydroxyvitamin D2 appeared at least as effective as 1 alpha-hydroxyvitamin D3 in correcting the bone disturbance.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005938:Glucocorticoids / Q000633:toxicity*; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D011239:Prednisolone / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D005938:Glucocorticoids; D006887:Hydroxycholecalciferols; D010758:Phosphorus; D011239:Prednisolone; D002118:Calcium; C008088:alfacalcidol