title: Ultraviolet radiation-induced histopathologic changes in the skin of the marsupial Monodelphis domestica. II. Quantitative studies of the photoreactivation of induced hyperplasia and sunburn cell formation.
abstract: Induction of sunburn cells (SBCs) and hyperplasia of the epidermis of the marsupial Monodelphis domestica by ultraviolet radiation (UVR) has been studied. A dose of 500 J/m2 (approximately 1 minimal erythemal dose) from an FS-40 sunlamp induced measurable numbers of SBCs with a peak number at 32-48 h post-UVR exposure of skin to photoreactivating light suppressed the induction of SBCs by approximately 75%. Pre-UVR exposure to photoreactivating light had no effect on the induction of SBCs. Induction of hyperplasia also was suppressed to a similar extent by post-UVR photoreactivation treatment. These studies identify pyrimidine dimers in DNA as the major photoproduct involved in the induction of SBCs and hyperplasia in M. domestica by UVR.
mesh_terms: D000818:Animals; D001706:Biopsy; D004247:DNA / Q000528:radiation effects; D006965:Hyperplasia / Q000209:etiology; D008027:Light; D009893:Opossums / Q000502:physiology*; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D013471:Sunburn / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D004247:DNA