Quinuronium levels in ovine plasma as determined by an in vitro/in vivo system with Babesia rodhaini.
Quinuronium was shown to have a babesicidal activity in vitro. In vitro/in vivo system with Babesia rodhaini gave an in vitro EC50 for 13.5 ng/ml. Quinuronium levels in ovine plasma increased to a maximum mean of approximately 27 ng/ml at 2 hours with a gradual decay from 8 hours up to almost no detectable levels at 48 hours following administration of therapeutic dose (1 mg/kg s.c.). This study supports previous reports of the use of Babesia rodhaini as an organism in screening antibabesials. The in vitro/in vivo model can be used to monitor quinuronium levels in ovine plasma. Second treatment with quinuronium may be administered after 24 to 48 hours whenever clinically indicated.
D000818:Animals; D000981:Antiprotozoal Agents / Q000097:blood* / Q000494:pharmacology; D001403:Babesia / Q000187:drug effects*; D001681:Biological Assay; D004912:Erythrocytes / Q000469:parasitology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011806:Quinolinium Compounds / Q000097:blood* / Q000494:pharmacology; D012756:Sheep; D013997:Time Factors; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
D000981:Antiprotozoal Agents; D011806:Quinolinium Compounds; D014508:Urea; C009154:quinuronium sulfate