Variations of interferon inactivators and/or inhibitors in human serum and their relationship to interferon therapy.
Anti-interferon (IFN) activities of normal human sera and sera from cases suspected of viral infection were determined. Of the normal sera tested (57), 65% presented anti-IFN activities against IFN-alpha and/or -beta preparations; 61% against IFN-beta and 32% against IFN-alpha. Of the sera from suspected virus-infected individuals (44), 82% presented anti-IFN activity to IFN-beta and 57% to IFN-alpha with the majority of sera (91%) exerting anti-IFN activities to IFN-alpha and/or -beta preparation. The observed variations of anti-IFN alpha and beta activities of human sera appear to be reproducible and should be taken into consideration in the clinical application of IFN.
D006801:Humans; D007370:Interferon Type I / Q000037:antagonists & inhibitors*; D014777:Virus Diseases / Q000097:blood*
D007370:Interferon Type I