title: Anaerobic osteomyelitis in sickle cell disease: association and pathophysiology.
abstract: A 10-year-old boy with sickle cell disease developed osteomyelitis of the humerus associated with blood cultures positive for Bacteroides fragilis. Clinical and radiological resolution followed a 10-day course of intravenous clindamycin. Attention is drawn to the definite but poorly recognized association between sickle cell disease and anaerobic osteomyelitis, and the probable pathophysiology is described.
mesh_terms: D000693:Anaerobiosis; D000755:Anemia, Sickle Cell / Q000150:complications*; D001441:Bacteroides fragilis; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology
chemical_list: D002981:Clindamycin