[Tissue diffusion of flumequine into human renal and prostatic tissues. Assay of flumequine by high performance liquid chromatography after administration of 800 mg/day over 48 hours, the sampling being done 12 hours after the last ingestion].
Diffusion of flumequine into human renal and prostatic tissues was studied. Chemical characteristics and the natural antibacterial spectrum of the compound are described and its rapidity of absorbtion emphasized, blood levels being detected 30 minutes after administration. Maximum plasma levels were reached after 2 to 3 hours and were of the order of 17 mcg/ml, half-life being approximately 10 hours. Plasma protein binding capacity was 60 to 70%, indicating liposolubility enabling diffusion into prostatic parenchyma. Flumequine was recovered in the urine 2 hours after oral administration, maximum urinary concentrations being reached after between 3 and 6 hours, and being of the order of 280 mg/ml after single-dose 40 mg administration. The product was still recovered from the urine 12 hours later, and 60 to 70% of the dose administered after 24 hours, including 20.6% of active form. To evaluate renal and prostatic tissue diffusion 2 series of patients were studied 10 after renal surgery and 14 prostatic operations. Diffusion was excellent into renal parenchyma since the mean ratio between renal tissue and plasma concentrations was 2.41. Urine concentrations were even more extraordinary since the ratio was 136. In contrast, prostatic tissue concentrations were lower than plasma concentrations, the ratio between the two being 0.26, although levels is prostatic tissue were still sufficiently elevated to be effective against germs sensitive to flumequine.
D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D024841:Fluoroquinolones; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011807:Quinolizines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D000892:Anti-Infective Agents, Urinary; D024841:Fluoroquinolones; D011807:Quinolizines; C012976:flumequine
Etude de la diffusion tissulaire de la fluméquine chez l'homme dans les tissus rénaux et prostatiques. Dosage de la fluméquine par chromatographie liquide haute performance aprés administration de 800 mg/jour pendant 48 heures, le prélèvement étant fait 12 heures aprés la derniére prise.