Timolol in aqueous humour after topical administration. A pilot study.
The concentration of timolol in aqueous humour after one single drop of timolol ophthalmic solution was studied in 19 patients. Relatively high concentrations were found (mean: 626 ng/ml), but the individual differences were great (range: 0 ng/ml - 2080 ng/ml). Possible explanations are discussed. No detectable levels of timolol were found in plasma (detection level greater than or equal to 1 ng/ml).
D000328:Adult; D000368:Aged; D001082:Aqueous Humor / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010865:Pilot Projects; D013999:Timolol / Q000008:administration & dosage / Q000032:analysis*
D009883:Ophthalmic Solutions; D013999:Timolol