Comparative effects of khellin and timefurone on serum parameters in normal male cynomolgus monkeys.
Timefurone and khellin (10 mg/kg/day, gavage, 14 days) significantly lowered low density lipoprotein cholesterol, high density lipoprotein cholesterol, and total cholesterol. Khellin-induced changes were significantly greater than those induced by timefurone. Neither drug altered body weights or clinical chemistry parameters. Monkeys treated with khellin, however, exhibited elevated levels of very low density lipoprotein cholesterol and marked emesis, while no changes were observed with timefurone. On the basis of these data, timefurone has a better therapeutic ratio and further study with this promising drug appears warranted.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D007666:Khellin / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D008251:Macaca / Q000097:blood*; D008252:Macaca fascicularis / Q000097:blood*; D008297:Male; D009325:Nausea / Q000139:chemically induced
D001578:Benzopyrans; D008074:Lipoproteins; C030104:lipoprotein cholesterol; C046829:timefurone; D007666:Khellin; D002784:Cholesterol