[Erythrocyte-damaging and immunomodulating effect of retinoids].
The influence of retinyl acetate, retinoic acid and its esterified cis- and trans-derivatives, retinoids C15 and C20 on erythrocytes, liver macrophages and white pulp of the spleen was studied in the experiments on mice of different strains. It was found that administration of these compounds leads to the damage of the blood cells, increase in the number of liver macrophages and the share of white pulp in the spleen and stimulation of the local response to tuberculin. The interdependence of changes in the blood and adjuvant is suggested.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004224:Diterpenes; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012176:Retinoids / Q000494:pharmacology*; D000084562:Retinyl Esters; D013154:Spleen / Q000187:drug effects; D014212:Tretinoin / Q000031:analogs & derivatives / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D004224:Diterpenes; D012176:Retinoids; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin; C026296:methyl retinoate
Eritrotsitpovrezhdaiushchee i immunomoduliruiushchee deĭstvie retinoidov.