title: Immunological effect of cycloheximide in mice.
abstract: We evaluated the effects of cycloheximide on two immune responses in the mouse. The data obtained in this series of experiments showed enhancement of the direct splenic plaque-forming cell response to sheep red blood cells when the drug was administered at doses of 25 and 50 mg/kg i.p. and of the delayed type hypersensitivity reaction to oxazolone when cycloheximide was injected at doses of 10, 25 and 50 mg/kg i.p. Depression of these responses was observed when the dose of drug injected was 75 or 100 mg/kg i.p. At a dose of 5 mg/kg cycloheximide had no effect on these immune responses.
mesh_terms: D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010081:Oxazolone / Q000276:immunology; D012756:Sheep; D013154:Spleen / Q000187:drug effects
chemical_list: D010081:Oxazolone; D003513:Cycloheximide