[Receptor binding of corticosterone in various structures of the rat brain after neonatal blockade of the hypophyseal-adrenal system].
The administration of hydrocortisone to rats on the first 5 days of life causes a blockade of the hypophyseal-adrenal system and results in a decrease in the number of corticosterone receptors in the hypophysis, hypothalamus and hippocamp. Such a decrease in the receptor binding of corticosterone in the brain structures involved in the regulation of the hypophyseal-adrenal system by the feedback mechanism, is determined by change in the number of true glucocorticoid receptors.
D000818:Animals; D000831:Animals, Newborn; D003345:Corticosterone / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005500:Follow-Up Studies; D006624:Hippocampus / Q000378:metabolism*; D006854:Hydrocortisone / Q000008:administration & dosage; D007031:Hypothalamus / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013997:Time Factors
D011965:Receptors, Glucocorticoid; D003345:Corticosterone; D006854:Hydrocortisone
Retseptornoe sviazyvanie kortikosterona v nekotorykh strukturakh mozga krys posle neonatal'noĭ blokady gipofizadrenalovoĭ sistemy.