Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
The effects of gomisin A, which is a lignan component of schizandra fruits, on liver functions in various experimental liver injuries and on bile secretion in CCl4-induced liver injury were studied. Gomisin A weakly accelerated the disappearance of plasma ICG by itself at a high dose (100 mg/kg, i.p.). All of the hepatotoxic chemicals used in this study inhibited the excretion of ICG from plasma. Gomisin A showed a tendency to prevent the delays of the disappearance of plasma ICG induced by CCl4, d-galactosamine and orotic acid, but not that by ANIT. Bile flow and biliary outputs of total bile acids and electrolytes (Na+, K+, Cl- and HCO3-) were decreased in CCl4-treated rats. Gomisin A maintained bile flow and biliary output of each electrolyte nearly to the level of the vehicle-treated group, but did not affect biliary output of total bile acids. These findings suggest that gomisin A possesses a liver function-facilitating property in normal and liver injured rats and that its preventive action on CCl4-induced cholestasis is due to maintaining the function of the bile acids-independent fraction.
D015058:1-Naphthylisothiocyanate / Q000633:toxicity; D000818:Animals; D001646:Bile / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D034242:Cyclooctanes; D004149:Dioxoles; D005688:Galactosamine / Q000633:toxicity; D007208:Indocyanine Green; D017705:Lignans; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D009963:Orotic Acid / Q000633:toxicity; D011083:Polycyclic Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D034242:Cyclooctanes; D004149:Dioxoles; D017705:Lignans; D011083:Polycyclic Compounds; D015058:1-Naphthylisothiocyanate; C033585:schizandrol B; D009963:Orotic Acid; D005688:Galactosamine; D007208:Indocyanine Green