Mutagenic activity in rat urine after feeding with the azo dye tartrazine.
The azo dye tartrazine, after dosing by gavage, is transformed by rats into urinary metabolites which exert dose-dependent mutagenic activities in the Ames test with Salmonella typhimurium TA 98 after addition of rat liver metabolizing enzymes (S9 mix). The strain TA 100 showed no mutagenic response.
D000818:Animals; D001391:Azo Compounds / Q000652:urine*; D001711:Biotransformation; D005260:Female; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013645:Tartrazine / Q000378:metabolism / Q000652:urine*
D001391:Azo Compounds; D009153:Mutagens; D013645:Tartrazine