d-Amphetamine raises cortisol levels in schizophrenic patients with and without chronic naltrexone pretreatment.
Five drug-free schizophrenic patients received an infusion of 20 mg d-amphetamine and placebo on separate days in a pilot study. Plasma cortisol levels rose significantly at 1 and 2 hours after d-amphetamine compared to following placebo. A repeat infusion of d-amphetamine during naltrexone treatment led to a similar increase in cortisol concentrations.
D000328:Adult; D002940:Circadian Rhythm; D003913:Dextroamphetamine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009271:Naltrexone / Q000008:administration & dosage*; D011292:Premedication; D012559:Schizophrenia / Q000097:blood*
D009271:Naltrexone; D003913:Dextroamphetamine; D006854:Hydrocortisone