Indomethacin-induced renal insufficiency: recurrence on rechallenge.
We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. Our case supports the hypothesis that endogenous renal prostaglandins play a role in the maintenance of renal blood flow when circulating plasma volume is diminished. Since nonsteroidal anti-inflammatory agents interfere with this compensatory mechanism and may cause acute renal failure, they should be used with caution in such patients.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology; D000328:Adult; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D010359:Patient Readmission; D010953:Plasma Volume / Q000187:drug effects; D012008:Recurrence; D012079:Renal Circulation / Q000187:drug effects
D007213:Indomethacin