[Complement fixation activity of immunoglobulin G in ethylene glycol solutions].
Affinity of IgG to the first complement factor C1q was found out to increase in 10-30% glycol solutions. Analytical ultracentrifugation and turbidity data showed that IgG molecules do not aggregate at such concentrations of glycol. The complement-binding effect may be caused by a conformational transition in the IgG molecules.
D000818:Animals; D003172:Complement C1 / Q000378:metabolism*; D003168:Complement Fixation Tests; D005026:Ethylene Glycols; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D011487:Protein Conformation; D012996:Solutions
D003172:Complement C1; D005026:Ethylene Glycols; D007074:Immunoglobulin G; D012996:Solutions
Komplementfiksiruiushchaia aktivnost' immunoglobulina G v rastvorakh étilenglikolia.