title: Inactivated polio vaccine: industrial production from micro-carrier Vero cells culture.
abstract: In 1980, we presented our preliminary results of large-scale production of Inactivated Polio-Vaccine (IPV). The virus was produced by Vero cells culture grown on micro-carrier in 150 litre tanks; now we produce the poliovirus in 1000 litre tanks. All the tests certifying the 'Cell Bank' have been passed; the quality of purification procedure was demonstrated; additional clinical studies were done; this new reassessed IPV was licensed in France in July 1982.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004345:Drug Industry; D011054:Poliovirus Vaccine, Inactivated; D051381:Rats; D014613:Vaccines, Attenuated
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D014613:Vaccines, Attenuated