[Functional state of the hepatocyte cytoplasmic network in heliotrine injury of the rat liver].
Effect of an alkaloid heliotrine (25 mg per 100 g of body mass) on the functional state of cytoplasmic net in rat hepatocytes was studied. Distinct prolongation of hexenale sleep, decrease in content of protein, cytochromes P-450 and b5 as well as inhibition of oxidative degradation of amidopyrine and aniline in liver microsomal fraction were found. The data obtained suggest that a decrease in the rate of xenobiotics biotransformation in hepatocytes is one of the factors responsible for intoxication of a body and for impairment in pharmacodynamics of the drugs metabolized in liver tissue under conditions of acute toxic hepatites.
D000818:Animals; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000378:metabolism*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003573:Cytochrome b Group / Q000037:antagonists & inhibitors; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D006900:Hydroxylation; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D014176:Protein Biosynthesis; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*; D051381:Rats; D012890:Sleep / Q000187:drug effects
D065607:Cytochrome P-450 Enzyme Inhibitors; D003573:Cytochrome b Group; D011763:Pyrrolizidine Alkaloids; D006591:Hexobarbital; C010178:heliotrine
Funktsional'noe sostoianie tsitoplazmaticheskoĭ seti gepatotsitov pri geliotrinovom porazhenii pecheni krys.