Dialysis osteomalacia: a possible role for zirconium as well as aluminium.
Six patients with dialysis osteomalacia were studied before and after treatment with desferrioxamine. Before treatment, all six had severe osteomalacia with histochemical evidence of metals at the mineralization front, confirmed by energy dispersive X-ray microanalysis to include Al, Zr and Fe. Zr was not detected by histological staining in patients without dialysis osteomalacia. After treatment a decrease of Al and Zr was associated with improvement in clinical, biochemical, radiological and histological parameters. These observations suggest the possibility of a role for metals other than Al in the pathogenesis of dialysis osteomalacia.
D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D003676:Deferoxamine / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000378:metabolism; D006801:Humans; D010018:Osteomalacia / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D015040:Zirconium / Q000378:metabolism
D015040:Zirconium; D003676:Deferoxamine