A case report of phenytoin encephalopathy. Correlation between serum levels, seizure increase and E.E.G. spike and wave activity.
In a case of phenytoin (PHT) encephalopathy a correlation was found between rising PHT serum levels and increase in seizure frequency. Supporting the correlation was the concomitant increase of E.E.G. spike and wave activity to 25% of the registration time. The rise in the PHT serum levels was possibly related to a drug interaction with carbamazepine. In addition neuropsychological assessment indicated reversible mental deterioration and deficits in motor skills and visual perception.
D001927:Brain Diseases / Q000139:chemically induced*; D002220:Carbamazepine / Q000008:administration & dosage; D002675:Child, Preschool; D003292:Convulsants; D004347:Drug Interactions; D004569:Electroencephalography; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D012640:Seizures / Q000139:chemically induced
D003292:Convulsants; D002220:Carbamazepine; D010672:Phenytoin