title: Interaction of norepinephrine and superior cervical ganglion input in the rat pineal body.
abstract: The effects of superior cervical ganglion stimulation and the local application of norepinephrine or its antagonist propranolol were studied in 18 pineal cells. In 61% of the pineal cells, stimulation elicited excitation; the same cells also responded by excitation to norepinephrine ejection. When stimulation and norepinephrine ejection were applied together, summation (of the excitation) was observed in these cells. Several cells that failed to respond to stimulation did respond to norepinephrine ejection, but with the opposite pattern, i.e., decrease of firing rates. Propranolol prevented the norepinephrine-induced excitation and inhibition, as well as the excitation produced by stimulation. We suggest that norepinephrine regulates pineal activity by two routes: activation of the sympathetic neuronal input and inhibition by way of the circulation.
mesh_terms: D000818:Animals; D005728:Ganglia, Sympathetic / Q000378:metabolism / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010870:Pineal Gland / Q000294:innervation* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009638:Norepinephrine