X-ray powder diffraction and microscopic analysis of crystalluria in dogs with ethylene glycol poisoning.
Most of the urinary crystals in 2 dogs intoxicated with ethylene glycol had prismatic (rod-like, hippurate-like), and to a less extent, hemp seed or spindle shapes. Using X-ray powder diffraction and optical analysis, these crystals were identified as calcium oxalate monohydrate. A few crystals of calcium oxalate dihydrate (envelope shape) were also observed in the urine sediment. Their presence was confirmed by the appearance of weak X-ray peaks having interplanar spacings ranging from 0.617 to 0.620 nm, which are thought to correspond to the 200 X-ray reflection of calcium oxalate dihydrate. Thus, the 6-sided hippurate-like crystals in the urine of ethylene glycol-poisoned dogs are actually calcium oxalate monohydrate.
D000818:Animals; D002129:Calcium Oxalate / Q000032:analysis / Q000652:urine*; D003461:Crystallography; D004283:Dog Diseases / Q000652:urine*; D004285:Dogs; D005026:Ethylene Glycols / Q000506:poisoning*; D005260:Female; D008274:Magnesium / Q000032:analysis / Q000652:urine; D017616:Magnesium Compounds; D008297:Male; D010710:Phosphates / Q000032:analysis / Q000652:urine; D000069877:Struvite; D014961:X-Ray Diffraction
D005026:Ethylene Glycols; D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D000069877:Struvite; D008274:Magnesium