title: [Optimization of intracavity irradiation in the treatment of cancer of the corpus uteri using high-activity sources].
abstract: The paper is concerned with an analysis of the results of concomitant therapy of corpus uteri cancer, Stage I-II, in 70 patients with relation to the regimen of intracavitary irradation using high energy sources on the Agat-B afterloading unit. Therapeutic efficacy, the frequency and severity of radiation complications were evaluated depending on the regimen of contact irradiation. Short-term results of concomitant radiation therapy were improved when passing over from a scheme of intracavitary irradiation of 10 Gy a week to schemes of dynamic fractionation and twofold irradiation a week at a dose of 5 Gy. The authors emphasize the inappropriateness of the use of large focal doses of 10 Gy during contact irradiation with high energy sources because in these cases exceeding tolerance of normal tissues is observed, particularly in patients of advanced age with noticeable somatic pathology.
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008875:Middle Aged; D011879:Radiotherapy Dosage; D013997:Time Factors; D014594:Uterine Neoplasms / Q000401:mortality / Q000532:radiotherapy*
vernacular_title: Optimizatsiia vnutripolostnogo oblucheniia pri lechenii raka tela matki istochnikami vysokoĭ aktivnosti.