Effect of ketoconazole in combination with other inhibitors of sterol synthesis on fungal growth.
The effect of combination of ketoconazole with other sterol synthesis inhibitors on fungal growth was tested against a variety of fungi selected for resistance to ketoconazole. All of the sterol inhibitors, at concentrations lower than their MICs, caused an increase greater than fourfold in the ketoconazole susceptibility of some fungi. Some of the sterol synthesis inhibitors showed this effect with ketoconazole at levels that may be achieved clinically.
D000935:Antifungal Agents / Q000494:pharmacology; D004357:Drug Synergism; D005658:Fungi / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D007654:Ketoconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013261:Sterols / Q000096:biosynthesis*
D000935:Antifungal Agents; D013261:Sterols; D007654:Ketoconazole