Cyclical eosinophilia: a manifestation of periodic haemopoiesis?
A patient is described who has had a marked eosinophilia of unknown cause for 9 years in association with episodic facial swelling. Weekly blood counts for 8 months showed cyclical variations in eosinophils, neutrophils and monocytes (mean cycle length 35 d). Marrow culture studies showed fluctuation in the incidence of granulocyte-macrophage colonies (GM-CFC), and the proportion of eosinophil colonies was higher than the values reported for normals. The blood lymphocyte T4/T8 ratio was reversed, due to an increase of T8+ cells. It is suggested that this condition is a rare form of periodic haemopoiesis.
D000368:Aged; D000380:Agranulocytosis / Q000150:complications*; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000145:classification; D008297:Male; D009503:Neutropenia / Q000150:complications*; D010507:Periodicity