Nucleus raphe dorsalis in parkinsonism-dementia complex of Guam.
Recently, morphometric analysis has shown that the nucleus raphe dorsalis, which is presumed to project diffuse serotonergic fibers to the telencephalon, is affected in Alzheimer's disease. A similar study was conducted in this report in two patients with parkinsonism-dementia complex of Guam and a Guamanian control. It demonstrated a significant reduction in the number of large neurons, and the presence of abundant Alzheimer's neurofibrillary tangles in this nucleus.
D002452:Cell Count; D003704:Dementia / Q000473:pathology*; D006141:Guam; D006801:Humans; D008297:Male; D008875:Middle Aged; D009454:Neurofibrils / Q000145:classification / Q000473:pathology; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D011903:Raphe Nuclei / Q000473:pathology*; D013577:Syndrome