Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin.
Vessels identical to lymph node high endothelial venules (HEV) have been described in sites of non-lymphoid tissue lymphocyte accumulation. In this study the function of these (HEV-like) vessels has been investigated in BCG-induced skin lesions in the rat. By following the traffic of radiolabelled lymphocytes from the blood into the lesions the HEV-like vessels have been shown to be the preferred site of migration. The complicated development of the vessels has been studied and an hypothesis advanced to explain their inter-relationship with tissue and circulating lymphocytes.
D000818:Animals; D001345:Autoradiography; D001500:BCG Vaccine; D004727:Endothelium / Q000648:ultrastructure; D006099:Granuloma / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008214:Lymphocytes / Q000502:physiology* / Q000648:ultrastructure*; D008833:Microcirculation; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D013997:Time Factors; D014680:Veins / Q000473:pathology*; D014699:Venules / Q000473:pathology* / Q000648:ultrastructure
D001500:BCG Vaccine