Reduction of cisplatin ototoxicity by fosfomycin in animal model.
The protective effect of fosfomycin against cisplatin-induced ototoxicity was studied in rats. Sixty-four Fischer rats were injected intravenously with daily doses of 1, 2, 5, and 10 mg/kg of cisplatin with or without 300 mg/kg of fosfomycin for a varying period from 1 to 10 days. The total dose of 10 mg/kg of cisplatin was given equally in all animals. Inner ear damage appeared to be more reduced histopathologically in animals given both cisplatin and fosfomycin than in animals given cisplatin alone. Similarly, renal damage appeared to be reduced histopathologically and functionally by the combined administration of cisplatin and fosfomycin.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D003051:Cochlea / Q000187:drug effects*; D005578:Fosfomycin / Q000627:therapeutic use*; D006198:Hair Cells, Auditory / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced; D007759:Labyrinth Diseases / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051381:Rats
D005578:Fosfomycin; D002945:Cisplatin