Appearance of sulphite and S-sulphonates in the plasma of rats after intraduodenal sulphite application.
Before intraduodenal administration of sodium sulphite solutions to anaesthetized rats, the portal vein and the vena cava were cannulated for blood sampling. Examination of the plasma showed that S-sulphonates were present in both pre- and post-hepatic blood, whereas free sulphite was detectable in the portal blood only. It can be concluded that sulphite is absorbed and quickly metabolized, either by oxidation or by the formation of S-sulphonates.
D000818:Animals; D001711:Biotransformation; D004386:Duodenum / Q000378:metabolism; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal; D010084:Oxidation-Reduction; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains; D013447:Sulfites / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013451:Sulfonic Acids / Q000097:blood*; D014684:Venae Cavae
D013447:Sulfites; D013451:Sulfonic Acids