title: [Effect of antioxidants and complexons on the stability of the microbiological standard for mycoheptin].
abstract: Stability is one of the most important indices of the quality of antibiotic microbiological standards. At present the expiry date of the mycoheptin standard (a specially purified preparation) is 1 year when stored in sealed ampoules in an inert gas at a temperature of -20 degrees C. To prolong the expiry date of the standard the effect of various antiohidants and complexons on its stability was studied with the method of "accelerated aging". Sodium hexametaphosphate and Trilon B were tested as complexing agents and propyl gallate, ionol, N-phenyl-2-napththyl amine, mannitol and their mixtures were tested as antioxidants. The substances were applied in an amount of 3 per cent of the antibiotic weight. The favourable effect of the complexons on mycoheptin stability was shown. Their stabilizing effect was potentiated by addition of certain antioxidants.
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000592:standards*; D000935:Antifungal Agents / Q000494:pharmacology / Q000592:standards*; D000975:Antioxidants / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D004355:Drug Stability; D004356:Drug Storage; D011090:Polyenes / Q000494:pharmacology / Q000592:standards; D012996:Solutions; D013696:Temperature; D013997:Time Factors
chemical_list: D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000975:Antioxidants; D002614:Chelating Agents; D011090:Polyenes; D012996:Solutions; C008567:mycoheptin
vernacular_title: Izuchenie vliianiia antioksidantov i kompleksonov na stabil'nost' mikrobiologicheskogo standarta mikogeptina.