Fenclofenac-induced selective IgA deficiency in rheumatoid arthritis.
A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac. His arthritis remained quiescent while taking the drug and following its withdrawal his condition relapsed and his serum IgA level returned to normal. This case demonstrates the association of selective IgA deficiency with remission in rheumatoid arthritis induced by fenclofenac as well as aurothiomalate and sulphasalazine. It also shows severe relapse after withdrawal of fenclofenac.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D004406:Dysgammaglobulinemia / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D010648:Phenylacetates / Q000009:adverse effects*
D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D010648:Phenylacetates; C012970:fenclofenac