DDT supports the growth of an estrogen-responsive tumor.
MT2 cells, a clonal cell line of MTW9/PL cells originally obtained from a mammary adenocarcinoma, from estrogen-responsive tumors in Wistar-Furth rats. o,p'-DDT supports MT2 tumor growth at a rate similar to 17 beta-estradiol. This effect of o,p'-DDT is dose-dependent and specific, since the DDT congener p,p'-DDD, which does not bind to tumor estrogen receptors, does not support tumor growth. This is the first demonstration that DDT can support the growth of an estrogen-responsive tumor.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D003634:DDT / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D004967:Estrogens; D004958:Estradiol; D003634:DDT