title: Mania following change from trazodone to imipramine.
abstract: Case reports are presented of two depressed patients with probable bipolar disorder who did not respond to trazodone but developed mania when this drug was abruptly replaced with imipramine. Clinical and theoretical implications are discussed.
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D014196:Trazodone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007099:Imipramine; D014196:Trazodone