[Teratogenic potentially of single dose of thalidomide in JW-NIBS rabbits].
A single dose (500 mg/kg) of thalidomide was administered orally to pregnant JW-NIBS rabbits in various stages of organogenesis. Head anomalies in fetuses (anencephaly, holoprosencephaly and hydrocephaly) were induced at a high frequency by the maternal administration of thalidomide on day 7, and also in a few fetuses on day 8. These fetuses included those with an abnormal skull such as hypoplasia of cerebral and facial skull. Microphthalmia in fetuses was observed with a single administration from day 7 to 12 of gestation. Contracture of forearms and club foot in fetuses resulted from the maternal administration of thalidomide on day 8 or 9 of gestation, respectively. With a single administration on day 8 or 9 of gestation, kinky tail in fetuses resulted, and brachyury was observed with a high frequency from day 8 to 11 of gestation. Skeletal anomalies such as fusion or displacement of coccygeal vertebral bodies were observed at a high frequency with a single treatment from day 8 to 10 of gestation. Among the internal anomalies observed was abnormal lobation of the lung, resulting from a single treatment from day 6 to 15 of gestation (except for day 13), and abnormal lobation of the liver, induced from day 7 to 10. The cardiovascular anomalies were induced at a high frequency with a single treatment from day 7 to 9 of gestation. In the present experiment, the critical period for each anomaly produced by thalidomide in JW-NIBS rabbits was determined.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000757:Anencephaly / Q000139:chemically induced; D000818:Animals; D001921:Brain / Q000002:abnormalities; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced; D006849:Hydrocephalus / Q000139:chemically induced; D011247:Pregnancy; D011817:Rabbits; D013792:Thalidomide / Q000008:administration & dosage / Q000633:toxicity*
D013792:Thalidomide