Effect of calcium dobesilate and its interaction with aspirin on thrombus formation in vivo.
The effect of calcium dobesilate (calcium dihydroxy-2,5 benzenesulphonate) on thrombus formation in vivo was evaluated. Experimental thrombi were induced in a venule of a hamster cheek pouch following iontophoresis of adenosine diphosphate (ADP). Calcium dobesilate administered intraperitoneally as a single injection inhibited thrombus formation in a time- and dose-dependent manner. Furthermore, the combination of calcium dobesilate and aspirin resulted in the potentiation of the inhibition of thrombus formation.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D001557:Benzenesulfonates / Q000494:pharmacology*; D002123:Calcium Dobesilate / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents; D008297:Male; D008647:Mesocricetus; D013924:Thrombophlebitis / Q000517:prevention & control*
D001557:Benzenesulfonates; D005343:Fibrinolytic Agents; D002123:Calcium Dobesilate; D001241:Aspirin