Brevetoxin-B of Gymnodinium breve toxin-induced contractions of smooth muscles due to the transmitter release from nerves.
Brevetoxin-B (BTX-B), a Gymnodinium breve toxin, isolated from the dinoflagellate, produced contraction of guinea pig ileum and rabbit aorta. Atropine (10(-6) M) and phentolamine (10(-6) M) abolished the BTX-B (10(-7) or 10(-6)-induced contraction of the ileum or aorta, respectively. Tetrodotoxin and saxitoxin (both 5 x 10(-7) M) also abolished the responses to BTX-B in the both tissues. Results suggest that BTX-B produces smooth muscle contractions through the tetrodotoxin- and saxitoxin-sensitive release of transmitters from autonomic nerves.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004141:Dinoflagellida; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D035964:Oxocins; D011817:Rabbits; D000095702:Polyether Toxins
D008387:Marine Toxins; D035964:Oxocins; C043466:brevetoxin B; D000095702:Polyether Toxins