1,4-Thiomorpholine-3,5-dicarboxylic acid, a novel cyclic imino acid detected in bovine brain.
Gas-liquid chromatography of enriched bovine brain extract revealed the occurrence of several sulfur-containing compounds. By co-chromatography with authentic product and by mass-spectrometric analysis, one of these compounds has been identified as 1,4-thiomorpholine-3,5-dicarboxylic acid (TMDA). The possible derivation of TMDA from lanthionine is discussed. This represents the second S-containing cyclic amino acid so far discovered in a mammalian brain whose physiological significance has not yet been explored.
D000818:Animals; D001923:Brain Chemistry; D002417:Cattle; D002849:Chromatography, Gas; D007098:Imino Acids / Q000032:analysis*; D013058:Mass Spectrometry; D009025:Morpholines / Q000032:analysis*
D007098:Imino Acids; D009025:Morpholines; C049158:1,4-thiomorpholine-3,5-dicarboxylic acid