title: Biological action of estrogen on the epididymis of prepubertal rhesus monkey.
abstract: An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 10(-10) mol/l and a concentration of binding sites of 17.0 +/- 4.4 fmol/mg cytosol protein in the epididymis. In the prostate, the concentration of binding sites was 19.7 +/- 3.6 fmol/mg cytosol protein with a Kd of 5.42 X 10(-10) mol/l. In immature castrated monkeys, administration of estradiol dipropionate caused a significant increase in the weight, total protein and sialic acid content of the epididymis. This biological action of estrogen on the epididymis is presumably mediated via estrogen receptor.
mesh_terms: D000818:Animals; D001665:Binding Sites; D003600:Cytosol / Q000378:metabolism; D004822:Epididymis / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D005837:Genitalia, Male / Q000187:drug effects; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D019158:N-Acetylneuraminic Acid; D009929:Organ Size; D011467:Prostate / Q000378:metabolism; D012741:Sexual Maturation; D012794:Sialic Acids / Q000032:analysis; D013739:Testosterone / Q000494:pharmacology
chemical_list: D004967:Estrogens; D012794:Sialic Acids; D013739:Testosterone; D004997:Ethinyl Estradiol; D004958:Estradiol; C011310:moxestrol; D019158:N-Acetylneuraminic Acid