The influence of age on plasma lignocaine levels following tracheal spray in young dogs.
A study was conducted in puppies of one litter beginning before they were three weeks old and repeated up to six times in the first four months of life to determine whether any age-related changes in peak plasma lignocaine levels occurred following tracheal spray. These were significantly higher in the youngest group (less than 20 days) than in dogs 2-3 months of age. There was a significant negative correlation between peak plasma levels and age up to four months. The maximum level attained by any puppy was 4.48 ug/ml after 4 mg/kg tracheal lignocaine spray.
D000336:Aerosols; D000367:Age Factors; D000818:Animals; D004285:Dogs; D008012:Lidocaine / Q000008:administration & dosage* / Q000097:blood; D008657:Metabolic Clearance Rate; D014132:Trachea
D000336:Aerosols; D008012:Lidocaine