Contact allergy to photoproducts of musk ambrette.
A patient with photocontact allergy to musk ambrette was investigated with patch and photopatch testing with dilutions of musk ambrette and 4 other nitro-musk compounds (musk ketone, moskene, musk tibetine, musk xylene) as well as with in vitro ultraviolet-irradiated solutions of musk ambrette. Besides a strong photoallergy to musk ambrette, a plain contact allergy to photoproducts of musk ambrette was demonstrated. An attempt to isolate the photoproducts causing the plain contact allergy was performed by using a preparative thin layer chromatography technique. These isolated photoproducts were not, however, responsible for the contact allergy to the photodecomposed musk ambrette.
D000328:Adult; D003877:Dermatitis, Contact / Q000175:diagnosis*; D004136:Dinitrobenzenes / Q000276:immunology* / Q000528:radiation effects; D006801:Humans; D008297:Male; D009578:Nitrobenzenes / Q000276:immunology*; D010777:Photochemistry; D012882:Skin Tests; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D004136:Dinitrobenzenes; D009578:Nitrobenzenes; C020422:musk ambrette (artificial)