[Distribution of digoxin, digitoxin and their cardioactive metabolites in human heart and kidney tissue. A postmortem study].
A method was developed for the specific determination of digoxin and digitoxin, as well as their semisynthetic derivatives and dependent cardioactive metabolites, in autopsy samples of heart and kidney. A collective of six patients on long-term treatment with therapeutic doses of beta-acetyldigoxin had a mean myocardial digoxin content of 46.1 +/- 25.0 ng/g (SD); kidney: 50.3 +/- 30.3 ng/g. Digoxigenin bisdigitoxoside represented the second most important metabolite in heart and kidney; digoxigenin monodigitoxoside and digoxigenin follow, respectively. In a collective of seven patients on maintenance treatment with digitoxin, the mean tissue levels were higher but the metabolic pattern was similar (myocardial digitoxin content: 78.9 +/- 38.4 ng/g, renal content: 104.1 +/- 44.1 ng/g). The amount of digoxin formed by hydroxylation under long-term treatment with digitoxin in heart and kidney were approximately 10 ng/g. A case of digoxin intoxication differed both in the tissue content and in the metabolic distribution.
D000328:Adult; D000368:Aged; D001344:Autopsy; D004074:Digitoxin / Q000032:analysis*; D004076:Digoxigenin / Q000031:analogs & derivatives / Q000032:analysis; D004077:Digoxin / Q000032:analysis* / Q000506:poisoning; D005554:Forensic Medicine; D006801:Humans; D007668:Kidney / Q000032:analysis*; D008875:Middle Aged; D009206:Myocardium / Q000032:analysis*; D013405:Suicide
C023685:digoxigenin-bis(digitoxoside); C018046:digoxigenin-mono(digitoxoside); D004077:Digoxin; D004074:Digitoxin; D004076:Digoxigenin
Verteilung von Digoxin, Digitoxin und ihren kardioaktiven Metaboliten im menschlichen Herz- und Nierengewebe. Eine post mortem-Untersuchung.