Antinociceptive and other opioid effects of a new series of dermorphin analogues after subcutaneous administration in the rat.
A series of hepta-, hexa-, penta- and tetrapeptide analogues of dermorphin have been evaluated in the rat for antinociceptive activity after subcutaneous (SC) administration at the screening dose of 4 mg/kg. Effective doses (ED50) were calculated for the most active compounds. Presence of spontaneous movements, defecation, micturition and corneal reflex were also recorded. Syntheses and analytical data of new derivatives are briefly reported.
D000595:Amino Acid Sequence; D000818:Animals; D003672:Defecation / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D008970:Molecular Weight; D009068:Movement / Q000187:drug effects; D009294:Narcotics / Q000494:pharmacology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D018847:Opioid Peptides; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014554:Urination / Q000187:drug effects
D009294:Narcotics; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin