[Mitotic cycle of a HeLa cell culture exposed to the maximum permissible concentrations of trace elements].
It is shown that administration of certain trace elements in maximum allowable concentrations induces changes in metabolism and functionation of cells in the culture. Zinc, nickel, cobalt, cadmium and fluorine are stated to inhibit mitotic activity of HeLa cells by the end of 24 hours of their action. Parallel with this they promote a decrease in H3-thymidine incorporation into DNA. Besides these substances delay various stages of the mitotic cycle for cells.
D001345:Autoradiography; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008452:Maximum Allowable Concentration; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors; D014131:Trace Elements / Q000494:pharmacology*
D014131:Trace Elements; D004247:DNA
Mitoticheskiĭ rezhim kul'tury kletok HeLa pri vozdeĭstvii predel'no dopustimykh kontsentratsiĭ riada mikroélementov.