title: Calcium influx in cultured carotid body cells is stimulated by acetylcholine and hypoxia.
abstract: Calcium influx was measured in cultured carotid body and glioma cells. In carotid body cells stimulation with acetylcholine (ACh, 10(-5) mol/l) increased the calcium influx to 135% of control values after 1 min and to 163% after 30 min. With a reduction of the pO2 to nearly zero calcium influx increased to 170% of control values. In glioma cells there was only a slight or no increase. This sensitivity of carotid body cells is discussed in relation to their function in chemoreception.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002344:Carotid Body / Q000378:metabolism*; D002460:Cell Line; D005910:Glioma / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D011817:Rabbits; D051381:Rats
chemical_list: D000109:Acetylcholine; D002118:Calcium