title: A randomized study comparing two high-dose per fraction radiation schedules in recurrent or metastatic malignant melanoma.
abstract: Thirty-five tumors in 14 patients with metastatic or recurrent malignant melanoma were randomized to high dose per fraction radiotherapy at either 9 Gy X 3 or 5 Gy X 8 twice weekly. Complete and persistent regression was found in 24/35 (69%) and partial response in 10/35 of the tumors. The overall response rate was 97%. No difference was observed between the two treatment regimens. Acute and late radiation damage to normal tissue was acceptable and of the same magnitude in both schedules.
mesh_terms: D004890:Erythema / Q000209:etiology; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000532:radiotherapy* / Q000556:secondary