Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats.
Selective section of afferent vagal axons that reach below the diaphragm blocks the satiating effect of peripherally administered cholecystokinin in the rat. Section of the analogous efferent axons has no effect. After the behavioral tests, the selective axonal sections were confirmed with horseradish peroxidase histochemistry.
D000005:Abdomen; D000818:Animals; D001369:Axons / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000502:physiology*; D012528:Satiety Response / Q000502:physiology*; D012844:Sincalide / Q000494:pharmacology*; D014630:Vagus Nerve / Q000502:physiology*
D012844:Sincalide