Deregulation of immunoglobulin expression: is this the main cause of Burkitt's lymphoma?
We here examine the role of c-myc in the aetiology of Burkitt's lymphomas. We suggest that c-myc causes cellular clones to become immortal while the deregulation of cell multiplication is the consequence of an altered production and/or structure of immunoglobulin chains caused by the 8-14, 8-2 or 8-22 translocations. Data relative to other immunoproliferative disorders are consistent with the hypothesis that the immunoglobulins play a key role in the regulation of the multiplication of lymphocytic cells.
D002051:Burkitt Lymphoma / Q000209:etiology* / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D009857:Oncogenes; D014178:Translocation, Genetic
D007136:Immunoglobulins