[Histochemical and ultrastructural evaluation of myocardial protection during correction of congenital heart defects with cardioplegia].
A combined stepwise light- and electron-microscopic examination of myocardial incision biopsies was carried out in 129 children with congenital valvular defects that were corrected under hypothermal extracorporeal circulation making use of cold or combined drug cardioplegia. Changes in the myocardium were suggestive of its original weakness. Structural changes were small-focal and reversible. Drug cardioplegia allowed to switch off the heart for longer periods (115 min) of time, yet the maintenance of a stable temperature regimen should be regarded as the key factor of successful cardioplegia.
D002675:Child, Preschool; D006324:Heart Arrest, Induced; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*
Gistokhimicheskaia i ul'trastrukturnaia otsenka zashchity miokarda pri korrektsii vrozhdennykh porokov serdtsa v usloviiakh kardioplegii.