Increased low-affinity 3H-spiroperidol binding to rat cortical membranes after chronic antidepressant treatments.
Looking for receptor correlates of increased motor response to dopaminergic stimulation in rats after antidepressant treatments, we measured specific 3H-spiroperidol binding to membranes from various brain ureas in rats receiving chronically electroconvulsive shock (ECS), imipramine or trazodone. In all groups the low-affinity 3H-spiroperidol binding (KD approximately 3 nM) was increased in the cortex, but not in the subcortical areas.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002090:Butyrophenones / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004565:Electroconvulsive Therapy; D007099:Imipramine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism*; D014196:Trazodone / Q000494:pharmacology
D000928:Antidepressive Agents; D002090:Butyrophenones; D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D013134:Spiperone; D007099:Imipramine; D014196:Trazodone