title: Histochemical study on end-plate cholinesterase in aged mice.
abstract: The cholinesterase activity at the motor end-plate of aged mice was investigated histochemically. A relative quantitative method was applied for studying the reaction at end-plates by utilizing varying concentrations of eserine. The number of end-plates reacting at a concentration of more than 5 X 10(-6) M eserine was reduced in aged diaphragm but increased in aged soleus muscle at 10(-5) M eserine in comparison with those in the young. It seems likely that there is an age-related change in cholinesterase activities in relation to muscle fiber types.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D006651:Histocytochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D009045:Motor Endplate / Q000201:enzymology*; D009469:Neuromuscular Junction / Q000201:enzymology*
chemical_list: D000110:Acetylcholinesterase