Accelerated recovery from immune-mediated thrombocytopenia with plasmapheresis.
Autoimmune thrombocytopenia unresponsive to corticosteroid therapy developed in a 16-year-old female with long-standing Sjögren's syndrome. Serial plasma exchange caused a linear decrease in platelet antibody titer associated with a concomitant rise in platelet count. Statistical analysis of sequential platelet counts revealed an increase with plasmapheresis and immunosuppression that was significantly greater than that achieved with immunosuppression alone (p less than 0.005).
D000293:Adolescent; D001327:Autoimmune Diseases / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D010956:Plasmapheresis; D010976:Platelet Count; D011241:Prednisone / Q000627:therapeutic use; D012859:Sjogren's Syndrome / Q000150:complications / Q000628:therapy; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy*
D011241:Prednisone; D008775:Methylprednisolone