title: Long-term follow-up after single toxic exposure to trichloroethylene.
abstract: In an earlier report [Feldman and Lessell, 1967], neurologic findings following acute intoxication to trichloroethylene were presented. Facial anesthesia, asymmetric pupillary responses, and electrical evidence of sensorimotor neuropathy accompanied neuropsychological deficits, manifested by difficulty in solving sequential problems and poor memory affecting the acquisition of new information. Twelve years after the initial exposure, patches of hypalgesia over the malar eminences persisted and corneal reflexes remained absent, although sensation in the snout region was totally normal. Neuropsychological test results continued to demonstrate impaired attention and short-term memory as well as diminished visuospatial organization and sequencing, 16 years after exposure. In addition, MMPI profile and interview suggested continued depressive symptomatology. Eighteen years after exposure, findings included paresthesia and hypalgesia in the malar area of the face as well as myokymia of the facial muscles. Facial nerve latency studies were normal as were pattern shift visual evoked responses. The patient continued to have large pupils that reacted asymmetrically to light. In the right eye, contraction was synchronous in all segments of the sphincter. In the left eye, there was segmental contraction, suggestive of a tonic pupil. This report offers evidence of long-term residual oculomotor and ciliary reflex dysfunction as well as impaired neuropsychological performance as a result of acute TCE intoxication.
mesh_terms: D000342:Affective Symptoms / Q000139:chemically induced; D003391:Cranial Nerves / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D008950:MMPI; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced*; D009431:Neural Conduction / Q000187:drug effects; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000139:chemically induced*; D012018:Reflex / Q000187:drug effects; D012677:Sensation / Q000187:drug effects; D013997:Time Factors; D014241:Trichloroethylene / Q000506:poisoning*
chemical_list: D014241:Trichloroethylene