Dominant inheritance of syn-camptodactyly of the second and third toes with foot and lower limb asymmetry and scoliosis.
We describe a family in whom affected persons have the following anomalies in variable combination: camptodactyly of the second and/or third toes, partial syndactyly of second and third toes, foot and lower limb asymmetry, and scoliosis. The condition seems to be an autosomal dominant trait with apparently reduced penetrance and variable expressivity.
D000015:Abnormalities, Multiple / Q000235:genetics*; D005260:Female; D005532:Foot Deformities, Congenital; D005799:Genes, Dominant; D006801:Humans; D007231:Infant, Newborn; D007866:Leg / Q000002:abnormalities*; D008297:Male; D010375:Pedigree; D012600:Scoliosis / Q000235:genetics*; D013577:Syndrome; D014034:Toes / Q000002:abnormalities*