[Effect of phosphocreatine and phosphocreatinine on membrane phospholipid metabolism in acute myocardial ischemia].
The effect of phosphocreatine and phosphocreatinine on changes in crude lysophosphoglycerides (LPG) in the plasmatic membranes of canine heart, induced by short-term ischemia (an 8-minute-long occlusion of the left descending coronary artery), was examined. Ischemia caused a considerable rise in LPG level, with a mean 83% rise in lysophosphatidyl choline and a 168% rise in lysophosphatidyl ethanolamine. Intravenous administration of 300 mg/kg phosphocreatine or phosphocreatinine completely prevented the accumulation of LPG in the ischemic area. Since LPG have pronounced arrhythmogenic properties, the data obtained suggest that anti-arrhythmic activity of phosphocreatine and phosphocreatinine in acute myocardial ischemia results from the effect these substances have on membrane phospholipid metabolism in the ischemized area.
D000818:Animals; D003327:Coronary Disease / Q000378:metabolism*; D004285:Dogs; D005260:Female; D005994:Glycerophosphates / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D010725:Phosphocreatine / Q000031:analogs & derivatives / Q000494:pharmacology*
D005994:Glycerophosphates; D008563:Membrane Lipids; C017476:lysophosphoglycerides; D010725:Phosphocreatine; C025403:phosphocreatinine
Vliianie fosfokreatina i fosfokreatinina na metabolizm membrannykh fosfolipidov pri ostroĭ ishemii miokarda.