A clinicopathological study of seven cases of primary high-grade malignant non-Hodgkin's lymphoma of the central nervous system.
Seven cases of primary non-Hodgkin's lymphomas of the central nervous system are described. Six cases were diagnosed after pathologic examination of surgical material; in one case, a patient with acquired immunodeficiency syndrome, the diagnosis was made at autopsy. The mean age of the patients was 52 years. The lesions were supratentorial in all cases, and unifocal in 6: the autopsy case had multicentric lesions. The cytologic examination of the cerebrospinal fluid was performed in 3 cases and was negative. The most common histologic type was immunoblastic lymphoma. The mean postoperative survival time was 12 months; in 2 cases, surgery combined with radiotherapy prolonged the survival for more than 2 years. Leptomeningeal involvement was considered to indicate a poor prognosis.
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged