Studies on the identification of genetic risk for heritable colon cancer.
The limitations of the assignment of genetic risk status for colon cancer based on pedigree data are known. The purpose of this paper is to present two approaches being evaluated for the identification of genetic predisposition for colon cancer: in vivo studies on colonic mucosa and in vitro studies on dermal fibroblasts derived from high- and low-risk individuals.
D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D003111:Colonic Polyps / Q000235:genetics; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D005753:Gastric Mucosa / Q000166:cytology / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology; D008297:Male; D011336:Probability; D012306:Risk; D012854:Sister Chromatid Exchange