[Sex steroid hormones, their receptors and local immunologic processes in experimental carcinogenesis of the larynx].
An increased androgen binding capacity of cytoplasmic protein receptors matched by relative hyperandrogenism was observed in the blood serum of animals showing incipient precancerous changes due to methylcholanthrene treatment. Activated forms of lymphocytes and their production of immunoglobulins were registered locally. Absolute hyperandrogenism occurred at later stages, viz. in the course of the development of pretumorous and tumor processes in the larynx. The results suggest that laryngeal carcinogenesis induced by methylcholanthrene shifts rat's hormonal profile towards hyperandrogenism, which seems to be responsible for the development of precancerous and tumor processes in the organ at later stages.
D000818:Animals; D004958:Estradiol / Q000097:blood*; D007822:Laryngeal Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*; D013739:Testosterone / Q000097:blood*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D013739:Testosterone; D004958:Estradiol; D008748:Methylcholanthrene
Polovye steroidnye gormony, retseptory k nim i mestnye immunologicheskie protsessy pri éksperimental'nom kantserogeneze v gortani.