title: [State of microcirculation and the system of hemostasis in Sjögren's disease, Sjögren's syndrome and chronic parenchymatous parotitis].
abstract: Microcirculation and hemocoagulation were examined in 88 patients with Sjögren's disease and Sjögren's syndrome (SD and SS) in 20 patients with chronic parenchymatous parotitis (CPP) without a "dry syndrome", and in 20 healthy donors by conjunctival angioscopy, capillaroscopy of the nail matrix, and histological study of the salivary glands. Hemostasis was explored with the use of 37 tests. SD and SS patients manifested significantly more pronounced microcirculatory disorders versus donors (P less than 0.001) and CPP patients (P less than 0.001). In patients with hypergammaglobulinemic purpura, microcirculatory disorders were found to be enhanced (P less than 0.05). An indirect relationship between these disorders and the degree of lacrimation lowering was established. Intravascular disturbances increased as the process activity rose and diminished under the effect of prednisolone therapy. It is assumed that microcirculatory and hemocoagulation disorders play an important role in the pathogenesis of SD and SS.
mesh_terms: D000328:Adult; D000368:Aged; D001777:Blood Coagulation; D002908:Chronic Disease; D003228:Conjunctiva / Q000098:blood supply; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D010309:Parotitis / Q000503:physiopathology*; D012859:Sjogren's Syndrome / Q000503:physiopathology*
vernacular_title: Sostoianie mikrotsirkuliatsii i sistema gemostaza pri bolezni Shergena, sindrome Shergena i khronicheskom parenkhimatoznom parotite.