Demalonyl derivatives of guanidylfungin A and copiamycin: their synthesis and antifungal activity.
Guanidylfungin A was chemically modified by alkylation, reduction and/or demalonylation. Demalonylmethylguanidylfungin A became soluble in water and showed approximately eight-fold higher activity against fungi and Gram-positive bacteria than guanidylfungin A along with strongly fungicidal effect. Similarly, copiamycin was converted to demalonylmethylcopiamycin, which also showed higher antifungal activity than copiamycin itself.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D007783:Lactones / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D007783:Lactones; C000507:copiamycin; C043674:guanidylfungin A