Circulating prostatic acid phosphatase-immunoglobulin complexes in Sjogren's syndrome.
Elevated level of serum prostatic acid phosphatase (PAP) activity in a patient with Sjogren's syndrome was found to be due to the presence of PAP-immunoglobulin complexes in circulation. The patient did not have a prostatic malignancy. The complexes were demonstrated by counter-immunoelectrophoresis, protein A-Sepharose immunoprecipitation and agarose-gel electrophoresis. Free enzyme was not detected in serum, and the activity of the complexed enzyme was probably unaltered on binding with the immunoglobulins.
D000135:Acid Phosphatase / Q000097:blood* / Q000276:immunology; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis*; D011232:Chemical Precipitation; D003378:Counterimmunoelectrophoresis; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D011467:Prostate / Q000201:enzymology*; D012859:Sjogren's Syndrome / Q000201:enzymology* / Q000276:immunology
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D000135:Acid Phosphatase