Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma).
A rare granulosa cell tumor with Sertoli-Leydig cell tumor components (gynandroblastoma) arising in the left ovary was reported in a 63-year-old female. Microscopically, the tumor was composed predominantly of granulosa cells arranged mainly in a diffuse solid pattern, but in some areas there were a trabecular pattern and thecofibromatous stromal components. Also, well-differentiated Sertoli-Leydig cell tumor elements were present as a minor component. The tumor produced, endocrinologically, a large amount of estradiol, some androstenedione and a small amount of testosterone. The possibility that estradiol in the present tumor was produced predominantly from androstenedione via estrone was suggested by the results of an in vitro biosynthetic study.
D000735:Androstenedione / Q000378:metabolism; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008875:Middle Aged; D018309:Neoplasms, Gonadal Tissue / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D013739:Testosterone / Q000096:biosynthesis
D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol