[Formation of cells secreting antigen-dependent nonspecific immunoglobulins during immunization of mice with 2 T-independent antigens].
Immunization of BALB/c and C3H/A mice with T-independent antigens (Vi-antigen of Salmonella typhi and polyvinyl pyrrolidone PVP350) induces the appearance of both antibody-forming cells (AFC) and a sharp increase in the number of cells forming nonspecific immunoglobulins (nIFC). This effect is not related to mitogenic properties of the antigens. The number of nIFC formed after simultaneous injection of both T-independent antigens does not differ from that of nIFC formed during immunization with each of these antigens alone. Thus, there was no summation of nIFC number after injection of two T-dependent or one T-dependent and one T-independent antigens. The mechanisms of nIFC formation under the influence of T-dependent and T-independent antigens are discussed.
D000818:Animals; D000921:Antibody-Producing Cells; D000942:Antigens, Bacterial / Q000276:immunology*; D005260:Female; D007114:Immunization; D007136:Immunoglobulins / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011135:Polysaccharides, Bacterial; D011205:Povidone / Q000276:immunology*
D000942:Antigens, Bacterial; D007136:Immunoglobulins; D011135:Polysaccharides, Bacterial; D011205:Povidone
Obrazovanie kletok, sekretiruiushcikh antigenzavisimye nespetsificheskie immunoglobuliny, pri immunizatsii mysheĭ dvumia T-nezavisimymi antigenami.