Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility.
The influence of several nootropic drugs (piracetam, pyritinol, meclofenoxat, methylglucamine orotate (MGO) and dihydroergotoxine (DHET) on both the ethanol preference and the enhanced seizure susceptibility after a single dose of ethanol was studied. Piracetam, MGO and DHET reduce the ethanol drinking in ethanol-preferring mice. The enhanced seizure susceptibility after a single dose of ethanol was abolished by piracetam and MGO.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009963:Orotic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013569:Synapses / Q000187:drug effects; D014192:Trapidil / Q000031:analogs & derivatives / Q000494:pharmacology
C046930:AR 12456; D004088:Dihydroergotoxine; D000431:Ethanol; C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine; D014192:Trapidil; D010889:Piracetam