[Fatty-acid composition of staphylococci induced by antibiotic AL-87 as a marker of their resistance or sensitivity to the given antibiotic].
Three strains of S. aureus isolated from patients were studied and it was shown that their population was heterogenous with respect to antibiotic AL-87: it contained both the antibiotic sensitive and the antibiotic resistant species in different ratios. The fatty acid composition induced by low concentrations of the antibiotic (subbacteriostatic for the sensitive microorganism) characterized by predominance of branched chain fatty acids in the antibiotic sensitive microorganisms and straight chain fatty acids in the antibiotic resistant microorganisms may serve a marker of sensitivity or resistance. Therefore, the data are indicative of the presence of genetic information in staphylococci determining their resistance to antibiotic AL-87 not yet used in medical practice.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D005227:Fatty Acids / Q000032:analysis*; D006801:Humans; D011549:Pseudomonas; D013211:Staphylococcus aureus / Q000032:analysis / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D005227:Fatty Acids
Indutsirovannyĭ antibiotikom AL-87 zhirnokislotnyĭ sostav stafilokokkov kak marker ikh ustoĭchivosti ili chuvstvitel'nosti k dannomu antibiotiku.