title: Reactive perforating collagenosis.
abstract: Seven patients with reacting perforating collagenosis (RPC) were diagnosed from 1974 to 1982. Experimental production of lesions in two patients confirmed the contributory role of superficial trauma. The pathogenesis of RPC involves transepithelial elimination of altered collagenous bundles. This process may be observed in a wide variety of disparate skin diseases.
mesh_terms: D002675:Child, Preschool; D003094:Collagen / Q000378:metabolism; D003095:Collagen Diseases / Q000150:complications / Q000473:pathology*; D048909:Diabetes Complications; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology*
chemical_list: D003094:Collagen