title: Plasma thyroid hormones, growth and carcass measurements of genetically obese and lean pigs as influenced by thyroprotein supplementation.
abstract: A 2 X 2 factorial arrangement with two genotypes of pigs (genetically obese and lean) and two dietary treatments (basal, a 16% protein corn-soybean meal standard grower diet, and basal +220 ppm thyroprotein as iodinated casein) was used. The 28 gilts were housed individually and fed ad libitum from 121 d of age until slaughtered at 99 kg body weight. Compared with lean pigs, genetically obese pigs had significantly lower average daily gain and gain/feed, greater backfat thickness, smaller loin eye area, shorter carcass length and lower circulating plasma triiodothyronine (T3) concentration. However, both total plasma and free thyroxine (T4) concentrations were similar comparing obese and lean pigs. Supplementation with thyroprotein increased circulating plasma concentration of both total and free T4 and produced interactions with genotype in affecting daily gain and gain/feed of pigs. Thyroprotein reduced both daily gain and gain/feed in obese pigs, but increased daily gain and gain/feed in lean pigs. It is suggested, similar to the case with obese mice, that heat production of our genetically obese pigs may be more sensitive to thyroprotein administration compared with similar treatment of lean animals.
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000494:pharmacology*; D005260:Female; D007467:Iodoproteins / Q000494:pharmacology*; D009765:Obesity / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D013552:Swine; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D002364:Caseins; D007467:Iodoproteins; D013963:Thyroid Hormones; D014284:Triiodothyronine; C010353:thyroactive iodinated casein; D013974:Thyroxine