title: Reduced tissue androgen receptors in the congenitally obese male Zucker rat.
abstract: Androgen receptor (AR) concentrations were measured in the prostates and livers of the infertile congenitally obese male Zucker rat and their fertile non-obese litter-mates. In obese rats AR concentrations were significantly lower in both the liver (p less than 0.001) and the prostates (p less than 0.01) of the obese rats compared with the non-obese rats, despite similar plasma testosterone concentrations in both phenotypes. These findings suggest that a potential cause for the infertility observed in the obese Zucker rat is a reduced sensitivity of target tissues to circulating androgens.
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D011944:Receptors, Androgen / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
chemical_list: D011944:Receptors, Androgen; D013739:Testosterone