Study of the role of steroid receptors in human breast cancer.
Cytoplasmic estrogen receptors (ER) were studied in 200 female patients with primary breast cancer. Both ER and progesterone receptors (PgR) were studied in 38 patients. Of the 200 tumors, 55% were estrogen receptor-positive, of the 38 tumors, 34.2% were progesterone receptor-positive. The level of steroid receptors was compared with some parameters characterizing the host and the tumor. It was found that the level of ER correlated with the age factors and the menstrual status. The level of ER was higher in women with adrenal or involutive pathogenetic forms of breast cancer and in women with great body weight. There was not found any relation between the level of estrogen receptors and the stage of menstrual cycle as well as between the level of estrogen receptors and the content of sex chromatin in the tumors.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001835:Body Weight; D001943:Breast Neoplasms / Q000378:metabolism* / Q000532:radiotherapy; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D012728:Sex Chromatin / Q000032:analysis
D011960:Receptors, Estrogen