Inhibition of liver lipase in vivo leads to induction of de novo cholesterol synthesis in rat liver.
Rats were injected with control-gamma-globulins or anti-liverlipase. The anti-liverlipase treatment resulted in a 69-78% inhibition of the salt-resistant lipase activity (liver lipase) in the liver. De novo cholesterol synthesis was significantly higher in slices of livers from anti-liverlipase treated rats than from control-gamma-globulin injected rats. The anti-liverlipase treatment also affected all plasma lipoprotein fractions. If the rats had been fed a cholestyramine containing diet no effect of anti-liverlipase on cholesterol synthesis was found. In these rats the effects on plasma lipoprotein fractions were more pronounced than in the control fed rats.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis*; D002788:Cholesterol Esters / Q000096:biosynthesis; D002792:Cholestyramine Resin / Q000494:pharmacology; D005260:Female; D007106:Immune Sera / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000276:immunology; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D002788:Cholesterol Esters; D007106:Immune Sera; D008074:Lipoproteins; D002792:Cholestyramine Resin; D002784:Cholesterol; D008049:Lipase