title: Influence of dietary cyanide on immunoglobulin and thiocyanate levels in the serum of Liberian adults.
abstract: Serum thiocyanate, antibody titers to thiocyanates, and serum immunoglobulins (IgM, IgG, IgA) were measured in 73 Liberian adults normally consuming diets of low, moderate, high, or no (control) cassava-derived cyanide (CN(-)). When control and low groups (n = 40; daily intake less than 0.60 mg CN(-) per kg body weight) were contrasted with moderate and high groups (n = 33; daily intake greater than or equal to 0.60 mg CN(-) per kg body weight), the authors observed that (1) one-time serum thiocyanate measurements were not sensitive to long-term cyanide intake; however, (2) antibody titers to thiocyanates were positively correlated with cassava-based cyanide intakes (r = .22, P = 0.05); and (3) serum IgM, IgG, and IgA levels were elevated in individuals regularly consuming moderate and high levels of dietary cyanide. Possible responsible mechanisms and health implications are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003486:Cyanides / Q000494:pharmacology*; D004032:Diet; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007988:Liberia; D008297:Male; D008875:Middle Aged; D013861:Thiocyanates / Q000097:blood
chemical_list: D003486:Cyanides; D007136:Immunoglobulins; D013861:Thiocyanates; C031760:thiocyanate