title: The Raji cell radioimmunoassay in patients with systemic lupus erythematosus: clinical significance and relationship to other serologic variables assessed by discriminant analysis.
abstract: Our aim was to determine the clinical usefulness of the Raji cell radioimmunoassay (RIA) in 30 patients with systemic lupus erythematosus (SLE) studied over a 30-month period. Raji RIA correlated positively (p less than 0.001) with antibodies to dsDNA, anti-Sm, erythrocyte sedimentation rate and central nervous system involvement and inversely with the white blood count, hematocrit and CH50. There was a lack of correlation (p greater than 0.05) between the Raji RIA and cryoglobulins, Clq binding assay, lymphocyte count, rheumatoid factor and anti-RNP. Raji RIA values paralleled disease activity in 50% and were predictive of flares in 17%. By discriminant analysis, the Raji RIA could not predict nephritis as well as a variety of routine laboratory tests in SLE. The Raji RIA, while helpful in SLE, does not appear to offer any advantage over standard assays in monitoring SLE disease activity.
mesh_terms: D000936:Antigen-Antibody Complex / Q000032:analysis*; D005069:Evaluation Studies as Topic; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D011379:Prognosis; D011863:Radioimmunoassay / Q000379:methods*; D012699:Serology; D013223:Statistics as Topic
chemical_list: D000936:Antigen-Antibody Complex