Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man.
Patients with unilateral frontal- or temporal-lobe excisions were tested on a spatial and a nonspatial conditional associative task. These tasks required the learning of arbitrary associations between a set of stimuli and a set of responses. Patients with excisions from the left or right frontal cortex were severely impaired in learning both tasks. Patients with left or right temporal-lobe excisions that did not involve extensive damage to the hippocampal region were not impaired, whilst those with more radical involvement of the hippocampal region exhibited deficits that were material-specific and varied with the side of the lesion.
D000293:Adolescent; D000328:Adult; D001245:Association Learning / Q000502:physiology; D004827:Epilepsy / Q000601:surgery; D005260:Female; D005625:Frontal Lobe / Q000502:physiology / Q000601:surgery*; D006801:Humans; D007858:Learning; D007859:Learning Disabilities / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D013037:Spatial Behavior / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology / Q000601:surgery*