[The clinical pharmacokinetics of allopurinol. 2. Allopurinol/oxypurinol pharmacokinetics following allopurinol in single doses and multiple application].
In a pharmacokinetic study with 6 healthy volunteers the parameters for allopurinol and oxipurinol were compared following a single dose of allopurinol and multiple application of the drug. Pharmacokinetic data for allopurinol and oxipurinol are different after single doses and under steady state conditions. The oxipurinol half-life of 17 +/- 5.1 h is prolonged under steady state conditions to 19.7 +/- 5.8 h. Based on the results of this study and on data from different authors the range of 17-21 h is discussed as the most frequent oxipurinol half-life.
D000328:Adult; D000493:Allopurinol / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010117:Oxypurinol / Q000097:blood*; D011743:Pyrimidines / Q000097:blood*
D011743:Pyrimidines; D000493:Allopurinol; D010117:Oxypurinol
Untersuchungen zur klinischen Pharmakokinetik von Allopurinol. 2. Mitteilung: Allopurinol/Oxipurinol-Pharmakokinetik nach Allopurinol-Einzelgabe und nach Mehrfachapplikation.