title: Glomerular filtration response to acute ureteral obstruction in the dog.
abstract: In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 +/- 50.9 vs. 319 +/- 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 +/- 0.025 vs. 0.08 +/- 0.007) and an increase in ureteral pressure to 63.1 +/- 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 +/- 7.5 vs. 36.3 +/- 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 +/- 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D011312:Pressure; D012079:Renal Circulation; D013997:Time Factors; D014513:Ureter / Q000503:physiopathology; D014517:Ureteral Obstruction / Q000503:physiopathology*