[Partial splenectomy in homozygous beta-thalassemia].
Six children, 2 1/2 to 6 years old, with homozygous beta-thalassemia underwent partial splenectomy as indicated by splenomegaly and high blood transfusion requirement. A marked reduction of blood requirement has been achieved in 2 children with an annual blood transfusion volume up to 150 ml per kg body weight. The other four children required total splenectomy as blood requirement remained high and significant splenomegaly developed within few weeks after the partial splenectomy. The immunological function of the spleen residue remains still controversial and needs further evaluation. Partial splenectomy might be indicated therefore only in selected children with homozygous beta-thalassemia.
D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging; D013156:Splenectomy; D013789:Thalassemia / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery*
Partielle Splenektomie bei homozygoter beta-Thalassämie.