Vitamin E protects against metasystox-induced adverse effect on lipid metabolism in the rat brain and spinal cord.
The effects of vitamin E (alpha-tocopherol) on the rate of lipid peroxidation and lipase activity in the discrete areas of the brain and spinal cord were studied. Administration of metasystox in two different doses 1.0 and 2.0 mg/kg body weight intraperitoneally daily for 10 days have shown a dose-related depletion of total lipids, cholesterol and esterified fatty acids in the rat cerebral hemisphere, cerebellum, brain stem and spinal cord. The rate of lipid peroxidation and lipase activity showed dose-dependent increase in different regions of the CNS. Administration of alpha-tocopherol alone caused significant reduction of lipid peroxidation and lipase activity. When it was administered simultaneously with metasystox, alpha-tocopherol prevented the metasystox-induced increase of lipid peroxidation and lipase activity.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity; D009946:Organothiophosphorus Compounds; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D005227:Fatty Acids; D008054:Lipid Peroxides; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D010743:Phospholipids; D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol; C026086:methyl demeton; D008049:Lipase