Fractional deposition from a jet nebulizer: how it differs from a metered dose inhaler.
The fractional deposition from an Inspiron 'Mini-Neb' jet nebulizer was assessed in six normal and two asthmatic subjects using technetium-99m-labelled millimicrospheres of human serum albumin suspended in saline. Sixty-six per cent of activity was retained in the apparatus tubing, 20% exhaled, 2% deposited in the mouth and 12% was retained in the lungs. The nebulizer fractional deposition therefore differs from the findings reported for a metered dose inhaler (Newman et al. 1981; Spiro et al. 1984), where 80-85% of particles leaving the cannister deposits in the mouth, and only 5-10% in the apparatus. The lung fraction from a nebulizer is, however, similar to the 9-11% from an MDI.
D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000000981:diagnostic imaging; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D009333:Neck / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000008:administration & dosage*; D013270:Stomach / Q000000981:diagnostic imaging; D013667:Technetium
D000336:Aerosols; D012709:Serum Albumin; D013667:Technetium