title: Metabolism of 6,7-dimethoxy 4-(p-chlorobenzyl)-isoquinoline. I. Single-dose pharmacokinetics in the rat and mouse.
abstract: The pharmacokinetics of 6,7-dimethoxy 4-(p-chlorobenzyl) isoquinoline (PV 2) in mouse and rat show that it is 52% absorbed after oral administration and undergoes a marked hepatic first-pass effect (83%). Tissue distribution shows an affinity for the aorta, cardiac tissues and cerebral blood vessels. It is excreted in the urine (20% dose) and faeces (70%); biliary excretion is high (80% dose). It is metabolized mainly by O-demethylation to 6- and 7-desmethyl-PV 2 and 6,7-didesmethyl-PV 2, as well as to six other non-identified metabolites.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D001808:Blood Vessels / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014018:Tissue Distribution
chemical_list: C039604:6,7-dimethoxy-4-(4-chlorobenzyl)isoquinoline; D010208:Papaverine