Progressive paresis in sheep due to delayed neurotoxicity of triaryl phosphates.
This report describes the history, signs, histopathology, and diagnosis of a delayed neurotoxicity in Suffolk sheep caused by transmission oil. The signs of toxicity included hyperexcitability, a stiff gait, tetraparesis and inability to maintain sternal recumbency. The circumstances involved in exposure to the transmission oil were determined. Histopathology revealed widespread degeneration of axons in the spinal cord, especially their more distal portions.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009943:Organophosphorus Compounds / Q000009:adverse effects*; D010291:Paresis / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D013116:Spinal Cord / Q000473:pathology
D009943:Organophosphorus Compounds