title: Idiopathic thrombocytopenic purpura and pregnancy. Maternal platelet count and antiplatelet antibodies do not predict the risk of neonatal thrombocytopenia.
abstract: The aim of this study was to try to better characterize, on the basis of maternal platelet count and antiplatelet antibodies, women with ITP or a history thereof at risk of being delivered of a child affected by neonatal thrombocytopenia. Results show that either clinical classification or maternal platelet count were not effective in predicting the occurrence of neonatal thrombocytopenia. Effects of prednisone on platelet-bound and unbound antibodies were studied prospectively in 12 non-pregnant women with ITP; no increase of these parameters was observed after treatment. Thus, the risk of corticosteroid therapy in the management of pregnant ITP patients remains hypothetical and unproven.
mesh_terms: D000328:Adult; D000906:Antibodies / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D010976:Platelet Count; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000097:blood* / Q000276:immunology; D012306:Risk; D013921:Thrombocytopenia / Q000209:etiology*
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G