[Ultrastructural changes in Mycobacterium rubrum cells exposed to sulfochloranthine].
The object of this work was to study the effect of sulfochlorantine (SCA), a new disinfecting compound containing chlorine, on Mycobacterium rubrum cells. The sensitivity of the cells to this agent was studied as well as their ultrastructure at the doses 0.01, 0.025, 0.05 and 0.1%. Even at high doses, the cells did not die off immediately when their growth and division stopped. Changes in the ultrastructural organization of the cells depended on the concentration of SCA. The structure of the nucleoid, membranes and ribosomes was damaged. Considerable changes were found in the formation of cross septa. The structure of the cells wall was modified to a lesser degree. The results are consistent with the biochemical data available.
D002455:Cell Division / Q000187:drug effects; D004202:Disinfectants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000494:pharmacology; D006827:Hydantoins / Q000494:pharmacology*; D008854:Microscopy, Electron; D009161:Mycobacterium / Q000187:drug effects* / Q000648:ultrastructure; D009940:Organoids / Q000187:drug effects / Q000648:ultrastructure; D011122:Polyphosphates / Q000494:pharmacology*
D004202:Disinfectants; D004338:Drug Combinations; D006827:Hydantoins; D011122:Polyphosphates; C022876:sulfochloranthine
Ul'trastrukturnye izmeneniia v kletkakh Mycobacterium rubrum pri vozdeĭstvii sul'fokhlorantina.