Granulocyte adhesion to nephritic glomeruli through recognition of activated C4 and C3 in immune deposits.
Sections of rat kidney with bovine serum albumin nephritis were incubated either with a single component of complement or with several components in sequence and then reacted with granulocytes. The average number of granulocytes bound to a nephritic glomerulus was elevated in sections incubated with C4 or C3 and increases were most significant when C14, C142 or C1423 were incubated.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D003172:Complement C1 / Q000276:immunology; D003175:Complement C2 / Q000276:immunology; D003176:Complement C3 / Q000276:immunology*; D003181:Complement C4 / Q000276:immunology*; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology*; D006098:Granulocytes / Q000276:immunology*; D007678:Kidney Glomerulus / Q000276:immunology*; D051381:Rats; D012710:Serum Albumin, Bovine
D000936:Antigen-Antibody Complex; D003172:Complement C1; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D012710:Serum Albumin, Bovine