11-Deoxycortisol induces hepatic tryptophan oxygenase in rats.
11-Deoxycortisol (cortexolone) has previously been used as a glucocorticoid antagonist in vitro and in adrenalectomized rats. Antiglucocorticoid properties of 11-deoxycortisol in intact rats were examined by studying the effect of 11-deoxycortisol on the induction of hepatic tryptophan oxygenase (TO) by corticosterone. No antiglucocorticoid effect was observed. When 11-deoxycortisol was injected into rats, the TO activity increased. This was probably mainly caused by an elevation of the serum corticosterone level. The induction of TO by 11-deoxycortisol was inhibited by metyrapone. However, 11-deoxycortisol (100 mg/kg) was still not a glucocorticoid antagonist even in presence of metyrapone.
D015065:17-Hydroxycorticosteroids / Q000494:pharmacology*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D003350:Cortodoxone / Q000097:blood / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000201:enzymology*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014366:Tryptophan Oxygenase / Q000096:biosynthesis*
D015065:17-Hydroxycorticosteroids; D014366:Tryptophan Oxygenase; D003345:Corticosterone; D003350:Cortodoxone; D008797:Metyrapone