title: Impaired potassium and magnesium homeostasis in acute tubulo-interstitial nephritis.
abstract: Although acute tubulo-interstitial nephritis is increasingly recognized as a cause of acute renal failure, little is known about renal tubular function in this disease. We report on two patients with acute tubulo-interstitial nephritis who demonstrated abnormalities in proximal and distal tubular function. The first patient developed hyperkalemia presumably from a potassium secretory defect in the distal nephron. The second patient developed an incomplete Fanconi's syndrome with glycosuria and aminoaciduria and two heretofore unreported complications of acute interstitial nephritis: hypokalemia and hypomagnesemia secondary to urinary losses of these cations. Careful monitoring of renal tubular function is indicated in patients with acute tubulo-interstitial nephritis.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000596:Amino Acids / Q000652:urine; D005198:Fanconi Syndrome / Q000209:etiology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006029:Glycosuria / Q000150:complications; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008274:Magnesium / Q000502:physiology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009318:Natriuresis; D009395:Nephritis, Interstitial / Q000150:complications / Q000503:physiopathology*; D011188:Potassium / Q000502:physiology* / Q000652:urine
chemical_list: D000596:Amino Acids; D005665:Furosemide; D008274:Magnesium; D011188:Potassium