[Pathomorphology of uveitis caused by an echovirus].
The monkey eyes infested by inoculation into the eye anterior chamber of the ECHO-19 virus from children with uveitis were studied morphologically. It was established electron microscopically that the inoculated virus is replicated in the capillary endothelium and stromal cells of the uveal tract. Crystal-like accumulation of virions and degenerative changes in the organelles are observed in these cells. Acute granulomatous alterative-exudative-hemorrhagic uveitis with the destruction of the iris, ciliary body and processes and secondary changes in the cornea and crystalline lens with the symptoms of keratitis and cataract develop in the anterior part of the eye as observed in the light microscope. The anterior and posterior goniosynechia develop. An acute inflammatory process is further transformed into a progressing autoimmune inflammation.
D000818:Animals; D002522:Chlorocebus aethiops; D004457:Echovirus Infections / Q000209:etiology / Q000473:pathology*; D004727:Endothelium / Q000648:ultrastructure; D005123:Eye / Q000648:ultrastructure; D008252:Macaca fascicularis; D008854:Microscopy, Electron; D013997:Time Factors; D014605:Uveitis / Q000209:etiology / Q000473:pathology*
Patomorfologiia uveita, vyzvannogo virusom ECHO.