Effect of some smooth muscle stimulants and trypsin on the contraction of vas deferens of aging rats.
Contractions of vas deferentia induced by KCI or field stimulation were not different between mature and old rats. The effect of trypsin or BaCl2 but not bradykinin or carbachol on contraction induced by field stimulation was significantly different between mature and old rats. The increase of twitching contractions by trypsin may be due to its effect on presynaptic alpha-adrenoceptors. Trypsin treatment did not qualitatively alter the responses produced by agonists in the vas deferentia of mature and old rats.
D000375:Aging; D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D011916:Rats, Inbred F344; D014357:Trypsin / Q000494:pharmacology*; D014649:Vas Deferens / Q000187:drug effects
D014357:Trypsin