[Cytochemical research on the effect of a synthetic enkephalin analog on the protein content and enzyme activity of neurons].
Using quantitative cytochemical technique a study was made of the effect of the synthetic analog of the Tyr-D-Ala-Gly-Phe-NH2 on the content and concentration of proteins and on the activity of enzymes (aminopeptidase, glutamate dehydrogenase and acid phosphatase) in neurons of the brain motor cortex and nucleus caudatus of rabbits and rats. The essential changes of the parameters used were registered 3 days after neuropeptide injection. A 30 minutes effects of the synthetic analog of enkephalins in protein metabolism was not so pronounced as a 3 days effect, the former being observed only in neurons of the brain motor cortex. Long-lasting effects of the neuropeptide Tyr-D-Ala-Gly-Phe-NH2 on the metabolism in brain are discussed.
D000135:Acid Phosphatase / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism; D004745:Enkephalins / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004745:Enkephalins; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; C037379:tyrosyl alanyl-glycyl-phenylalaninamide; D005969:Glutamate Dehydrogenase; D000135:Acid Phosphatase; D000626:Aminopeptidases
Tsitokhimicheskoe issledovanie vliianiia sinteticheskogo analoga énkefalinov na soderzhanie belkov i aktivnost' nekotorykh fermentov v neĭronakh.