Autoregulation of ocular blood flow during changes in intraocular pressure. Preliminary results.
Visual evoked potentials were recorded in six normal subjects and in three patients with primary open-angle glaucoma, while intraocular pressure was artificially elevated in stepwise increases. The resulting perfusion-pressure amplitude curves in our controls showed a kink, which can be interpreted as a sign of vascular autoregulation. No kink was observed in the curves of our glaucoma patients, which we interpret as indicating a lack of vascular autoregulation in primary open-angle glaucoma.
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002924:Ciliary Body / Q000098:blood supply; D005074:Evoked Potentials, Visual; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply*; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000503:physiopathology