[Relation of the immunogenicity of artificial antigens to the number of polyelectrolyte-bound protein molecules].
Complexes and covalent conjugates of protein antigens with polyelectrolytes of different molecular mass have been synthesised. The structure and composition of the resulting water-soluble complex particles were determined. Artificial antigen immunogenicity was shown to depend on the amount of protein molecules complexed with polyelectrolytes. Direct correlation between immunostimulating activity of the polymer-carrier, immunogenicity of complex antigens and size-dependent capacity of the polymer molecule to aggregate protein globules has been established.
D000180:Acrylic Resins / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000941:Antigens / Q000276:immunology*; D002452:Cell Count; D007114:Immunization; D051379:Mice; D011145:Polyvinyls / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000180:Acrylic Resins; D000941:Antigens; D011145:Polyvinyls; C019535:poly(4-vinylpyridine); D012710:Serum Albumin, Bovine; C006903:carbopol 940
Zavisimost' immunogennosti iskusstvennykh antigenov ot kolichestva sviazannykh poliélektrolitom belkovykh molekul.