[Role of cytoplasmic receptors in the lympholytic action of glucocorticoids and ionizing radiation].
Exposure of thymocytes to 4 Gy X-radiation causes a marked change in the kinetics of accumulation of glucocorticoids in cells. The hormone-binding activity of the cytoplasmic receptors does not differ from the control level. Progesterone, a glucocorticoid antagonist, and aurin tricarboxylic acid, an inhibitor of protein receptors, protect thymocytes from the effect of glucocorticoids and ionizing radiation. It is assumed that the cytoplasmic receptor system is involved in the realization of the radiation effect.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000502:physiology*
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone
Izuchenie roli tsitoplazmaticheskikh retseptorov v limfoliticheskom deĭstvii gliukokortikoidov i ioniziruiushchego izlucheniia.