A comparative quantum chemical study of methyl acetate and S-methyl thioacetate. Toward an understanding of the biochemical reactivity of esters of coenzyme A.
The electronic structures of methyl acetate and S-methyl thioacetate and the corresponding anions have been investigated using the INDO-MO method. Equilibrium geometries, gas-phase anion proton affinities and barriers to internal rotation have been computed. Analysis of the effect of the d-type functions on sulfur on the static and dynamic properties of the thioester and its anion reveal no role for (p-d) pi conjugative effects. The results of this work indicate that the unique properties of thioester, and hence esters of coenzyme A, may be attributed to the lack of resonance, rather than to a sulfur d-orbital expansion.
D000085:Acetates; D000214:Acyl Coenzyme A / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011789:Quantum Theory; D013329:Structure-Activity Relationship
D000085:Acetates; D000214:Acyl Coenzyme A; C026500:methyl thioacetate; C046923:methyl acetate