Effects of leucine methylester on guinea-pig atria.
Superfusion of guinea-pig atria with 10 mM l-leucine methylester leads to a mechanical arrest and to an increase in protein outflow. Homogenate of atria exhibits a decrease in the sedimentability of phosphatase acid activity as compared to control. Morphological studies reveal that leucine methylester causes not only a lysosomal swelling but also a disruption of myofibrils and slight mitochondrial damage.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008247:Lysosomes / Q000187:drug effects; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects; D011506:Proteins / Q000378:metabolism
D011506:Proteins; C030365:leucine methyl ester; D000135:Acid Phosphatase; D007930:Leucine