Changes in intravascular fluid composition following blood replacement with perfluorocarbon emulsion in the rat.
The effects of near total blood replacement with the proprietary perfluorocarbon emulsion, Fluosol-DA, have been examined in conscious, chronically catheterized rats. Animals survived for up to 48 h with a haematocrit of less than 2%. No overt changes in cardiovascular or respiratory functions occurred during blood replacement but thereafter, animals showed a progressive deterioration of haemodynamic control. Changes in intravascular fluid composition during and following exchange-transfusion have been monitored and the extent to which these changes could have contributed to the eventual disruption of homeostasis is discussed.
D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D001802:Blood Substitutes / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004573:Electrolytes / Q000097:blood; D004906:Erythrocyte Count; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006895:Hydroxyethyl Starch Derivatives; D007958:Leukocyte Count; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D001802:Blood Substitutes; D004338:Drug Combinations; D004573:Electrolytes; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D014508:Urea