[DNA repair system in nonspecific lung diseases].
It has been found that in 35-40% of patients with acute and chronic pneumonia, the reduced ability of peripheral blood lymphocytes for DNA repair is encountered 14 times as frequently as in normal subjects. After discontinuation of antibacterial therapy with penicillin or tetracycline antibiotics marked inhibition of the ability of lymphocytes for DNA repair is recorded. The tendency toward normalization of this characteristic occurs 1 week after discontinuation of antibiotic therapy for acute and 3 weeks for chronic pneumonia. The disorders of the ability of peripheral blood lymphocytes for DNA repair in the conditions under study are regarded as a possible cause of secondary immunodeficiency.
D004260:DNA Repair / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008171:Lung Diseases / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure*; D010400:Penicillin G / Q000627:therapeutic use; D013754:Tetracyclines / Q000627:therapeutic use
D013754:Tetracyclines; D010400:Penicillin G
Sistema reparatsii DNK pri nespetsificheskikh zabolevaniiakh legkikh.