[Anticancer therapy of the genito-urinary tract and infection].
Infectious diseases will often occur in the genito-urinary tract cancer cases, who are undergone the therapy of anticancer drugs. The organisms isolated from these cases are almost so-called opportunistic pathogens. beta-lactam antibiotics are given frequently to these cases, because of the mechanisms of the antibacterial activity. The effects of beta-lactams on macrophage phagocytic and killing activity of P. aeruginosa are examined. Cells pretreated with Carbenicillin, Cefotaxime, Ceftazidime or AC-1370 caused a greater degree of decline of viable cells than the untreated control cells. Intravesical instillation of Adriamycin in superficial bladder tumor are very useful, but chemical-cystitis will find sometimes as side effect. Adriamycin 60 mg, Stronger neo-minophagen C 20 ml and saline 20 ml instill together to 24 cases once everyday for 10-44 days. Drop-out cases by chemical-cystitis are only 3. The detailed results will be reported elsewhere.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007769:Lactams; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000517:prevention & control; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy*; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D007769:Lactams; D004317:Doxorubicin