[Development of a high fibrinolytic potential around a thrombus using leukocyte Fc receptors loaded with streptase].
An effective way of inducing high fibrinolytic potential in the thrombus area by streptase-containing leucocytes has been suggested. Leucocytes were incubated with streptase and then placed in the solution containing a fibrin clot, the latter pre-treated with anti-fibrin serum. In these conditions the rate of fibrinolysis increased drastically. The authors believe that fibrinolysis is initiated by the interaction of activated leucocytes via Fc-receptors with fibrin and the release of endo- and exogenic fibrinolytic proteases.
D005342:Fibrinolysis; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D011961:Receptors, Fc / Q000502:physiology*; D013300:Streptokinase / Q000494:pharmacology*; D013927:Thrombosis / Q000628:therapy*
D011961:Receptors, Fc; D013300:Streptokinase
Sozdanie v oblasti tromba vysokogo fibrinoliticheskogo potentsiala s pomoshch'iu Fc-retseptorov leĭkotsitov, "nagruzhennykh" streptazoĭ.