title: Regional brain levels of N-acetyl-aspartyl-glutamate: the effect of kindled seizures.
abstract: Rats were subjected to daily amygdaloid-kindling stimulation and sacrificed 48 h after their fifth stage-5 kindled seizure. Regional brain dissection was performed and the regions assayed for levels of N-acetyl-aspartyl-glutamate, an endogenous dipeptide specific to the brain and a putative excitatory neurotransmitter. Kindling produced significant increases in this dipeptide in the entorhinal cortex.
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001923:Brain Chemistry; D004151:Dipeptides / Q000032:analysis*; D007696:Kindling, Neurologic; D008032:Limbic System / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism
chemical_list: D004151:Dipeptides; C027172:isospaglumic acid