title: Essential fatty acids in the fetal and newborn lamb.
abstract: The concentrations of linoleic and linolenic acids and their metabolites in the liver, kidney, brain, erythrocytes and plasma of fetal lambs at various stages of gestation, and of newborn and 2-week-old suckled lambs was determined. Throughout gestation the fetal tissues, erythrocytes and plasma all contained low levels of linoleic and linolenic acids together with consistently high levels of their long-chain polyunsaturated metabolites. The triene: tetraene (eicosa-5,8,11-trienoic acid/arachidonic acid) ratio was always 0.4 or less except at birth when it reached 0.6 in liver and 0.9 in plasma. Milk intake significantly increased the linoleic and linolenic acid levels in the lamb by 2 weeks after birth. These results show that the developing fetal lamb should not be regarded as being deficient in essential fatty acids, as suggested by previous investigators. It is proposed that the total metabolites of linoleic and linolenic acids are the most appropriate measure of the essential fatty acid status of the fetal lamb.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D004912:Erythrocytes / Q000032:analysis; D005228:Fatty Acids, Essential / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005260:Female; D005333:Fetus / Q000032:analysis*; D008055:Lipids / Q000097:blood; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D012756:Sheep / Q000378:metabolism*
chemical_list: D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D008055:Lipids