Quantitative assessment of the polysome profile of the livers of mice treated with tetracycline or doxycycline.
The influence of tetracycline and doxycycline (10-100 micrograms/g i.v.) on the aggregational state of ribosomes from mouse liver was tested. Both drugs caused a disaggregation of the ribosomes as evidenced by a rise of the monosomes + disomes/polysomes ratio. Tetracycline was much more potent than doxycycline, the minimum effective doses for tetracycline being 10 micrograms/g i.v. as compared to 100 micrograms/g for doxycycline. The results show that tetracycline but not doxycycline at therapeutic dose range may interfere with the protein synthesis of the liver.
D000818:Animals; D004318:Doxycycline / Q000494:pharmacology*; D005260:Female; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011132:Polyribosomes / Q000032:analysis / Q000187:drug effects*; D014176:Protein Biosynthesis; D013752:Tetracycline / Q000494:pharmacology*
D013752:Tetracycline; D004318:Doxycycline