title: Brain, spinal cord and adrenal catecholamine concentrations in neonate rats of the Lyon hypertensive strain.
abstract: The catecholamine concentrations were determined in brain parts, spinal cord and adrenals of neonate hypertensive rats of the Lyon strain (LH), compared to normotensive (LN) and low-blood-pressure (LL) control rats. In adrenals of LH rats, noradrenaline and adrenaline concentrations are increased, and 3,4-dihydroxyphenylacetic acid (DOPAC) concentration decreased. At the central level, the DOPAC concentration and the ratio DOPAC/dopamine are decreased in the mesencephalon and the forebrain of LH rats. These results suggest that neonate LH rats exhibit a decreased activity in central dopaminergic neurons, and an enhanced maturation of the adrenals.
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000313:Adrenal Medulla / Q000032:analysis*; D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D002490:Central Nervous System / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D005260:Female; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D051381:Rats
chemical_list: D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D009638:Norepinephrine