Influence of hormone therapy on human lung tumors transplanted into nude mice.
Specific estrogen, progesterone, androgen and glucocorticoid receptors were determined in 8 lung tumor lines transplanted into athymic nude mice. It was found that the receptor content for estrogen, progesterone or androgen was very low for all tumor lines tested, whereas the glucocorticoid receptor content was high in all cases except 1. The growth inhibition of lung carcinomas on nude mice by glucocorticoid or antiglucocorticoid treatment suggests that lung cancer may also be influenced by hormonal therapy.
D000818:Animals; D002460:Cell Line; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000378:metabolism; D006728:Hormones / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D011485:Protein Binding; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*
D005938:Glucocorticoids; D006728:Hormones; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid