Sarin intoxication elevates plasma pralidoxime.
Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication. Plasma levels after administration of 3.12 mg/kg of 2-PAM were elevated from a control mean of 6.18 micrograms/ml to a maximum of 13.78 micrograms/ml in animals given 557 micrograms/kg of sarin at 2 min after the injection of the therapeutic compounds. This suggests that pathophysiological changes following intoxication by potent inhibitors of cholinesterase result in a decrease in the rate and extent of distribution of therapeutic compounds. This effect is most likely a consequence of changes in cardiovascular functions influencing blood flow to various organs.
D000818:Animals; D006168:Guinea Pigs; D062025:Organophosphate Poisoning; D011220:Pralidoxime Compounds / Q000097:blood*; D012039:Regional Blood Flow / Q000187:drug effects; D012524:Sarin / Q000506:poisoning*
D011220:Pralidoxime Compounds; D012524:Sarin; C028797:pralidoxime