[Methodology and interpretation of morphiate detection in urine samples].
In TLC screenings of 335 urine samples taken because of suspicion of heroin consumption, positive evidence of morphine was found in about 50% of the cases, which was confirmed without exception by gas chromatography-mass spectrometry. In 66% of the positive cases, morphine and codeine were found; in about 31% only morphine was found, and the median value of 0.4 mg/l free morphine and 1.0 mg/l conjugated morphine was considerably lower than in the whole collection of samples. Comparison of the codeine/morphine quotients (Q), especially the free bases, proves that the groups of heroin/morphine or codeine consumers can be distinctly differentiated. The critical conditions of the conjugated bases worked out by Dutt et al. (1983) proved to be right. Using the equation Qf less than 0.5 square root c, a boundary condition for the free flare bases can also be developed, which is dependent on the sum of the codeine and morphine concentrations and which proves heroin/morphine consumption with 98% certainty.
D003061:Codeine / Q000031:analogs & derivatives / Q000652:urine*; D006556:Heroin Dependence / Q000652:urine*; D006801:Humans; D007700:Kinetics; D009020:Morphine / Q000652:urine*
D009020:Morphine; C014481:dihydrocodeine; D003061:Codeine
Methodik und Interpretation des Morphiat-Nachweises in Harnproben.