title: [Serum myoglobin following intermittent administration of succinylcholine and the effect of dantrolene. Clinical studies of children in halothane anesthesia].
abstract: Serum myoglobin concentration was observed over a period of 30 min following succinylcholine (SCH) in 30 children. They were uniformly anaesthetized with halothane; differences, however, concerned premedication and relaxation. They received in group 1 (n = 12) dantrolene 2 X 1 mg X kg-1 orally and SCH 2 X 1 mg X kg-1 i.v., in group 2 (n = 12) only SCH 2 X 1 mg X kg-1 i.v., and in group 3 (n = 6) neither dantrolene nor succinylcholine were used. The mean initial myoglobin concentrations were nearly identical (16.8-17.0 ng X ml-1). In the children without SCH (group 3) no changes could be observed; following SCH (group 2) the mean concentration increased to 1,610.5 ng X ml-1 after 30 min; additional premedication with dantrolene (group 1) led to a significant reduction of the myoglobin concentration (413.7 ng X ml-1; p = 0.031).
mesh_terms: D000758:Anesthesia; D002648:Child; D003620:Dantrolene / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D009126:Muscle Relaxation; D009211:Myoglobin / Q000097:blood*; D011229:Preanesthetic Medication; D011897:Random Allocation; D013390:Succinylcholine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D009211:Myoglobin; D003620:Dantrolene; D013390:Succinylcholine; D006221:Halothane
vernacular_title: Serummyoglobin nach Wiederholungsgaben von Succinylcholin und der Einfluss von Dantrolen. Klinische Untersuchungen bei Kindern in Halothannarkose.