Comparison of two sustained-release theophylline preparations in adult patients with obstructive airways disease.
The bioavailability profiles of two sustained-release oral theophylline preparations, Respbid and Theo-Dur, were compared in 19 adults with obstructive airways disease. Intravenous aminophylline was used as the reference standard. No significant differences were detected in fraction absorbed, peak-trough fluctuations, or time to peak concentrations.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001682:Biological Availability; D003692:Delayed-Action Preparations; D006801:Humans; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008875:Middle Aged; D011897:Random Allocation; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D013806:Theophylline