title: Complexation of the fungal metabolite tenuazonic acid with copper (II), iron (III), nickel (II), and magnesium (II) ions.
abstract: Tenuazonic acid (TA) is a phytotoxin produced by a fungal pathogen of rice, Pyricularia oryzae. We have synthesized and characterized the metal complexes of TA with copper (II), iron (III), nickel (II), and magnesium (II). The stoichiometry of the complexes determined by microanalysis and mass spectroscopy (D/CI) are Cu(II)TA2, Fe(III)TA3, Ni(II)TA2, and Mg(TA)2. Voltammograms of Fe(III)TA3, and Cu(II)TA2 in methanolic solutions confirmed this stoichiometry. Ni(II)TA2 paramagnetism and visible absorption data suggest an octahedral geometry. Fe(III)TA3 showed a characteristic visible absorption at 450 nm. Addition of Fe(III)Cl3 and Mg(II)Cl2 did not reverse the toxicity of NaTA to rice and bacterial cells, showing that this toxicity is not due to the privation of the cells of these metals essential for cell growth.
mesh_terms: D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D004577:Electron Probe Microanalysis; D007501:Iron; D008274:Magnesium; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009532:Nickel; D013053:Spectrophotometry; D013720:Tenuazonic Acid
chemical_list: D000903:Antibiotics, Antineoplastic; D013720:Tenuazonic Acid; D003300:Copper; D009532:Nickel; D007501:Iron; D008274:Magnesium