Freeze-fracture studies of muscle plasma membrane in Fukuyama-type congenital muscular dystrophy.
We used freeze-fracture to study muscle plasma membrane in six patients with Fukuyama-type congenital muscular dystrophy and six control children. In the patients, there was significantly fewer intramembranous particles (IMPs) and orthogonal arrays in the P face, with less conspicuous depletion of IMPs in E face. However, the density of caveolae was not affected.
D002462:Cell Membrane / Q000648:ultrastructure*; D002648:Child; D005614:Freeze Fracturing; D006801:Humans; D009136:Muscular Dystrophies / Q000151:congenital / Q000473:pathology*