Metabolic consequences of long-term thiazide-based antihypertensive treatment of renal hypertension.
In 72 outpatients with early stage disease and mild to moderate hypertension, metabolic parameters were evaluated before and during 6 years of treatment with two different thiazide diuretic-based antihypertensive therapy regimens. Compared to the untreated state, chronic diuretic treatment caused a persisting increase in serum lipids in men or postmenopausal women. The high incidence of electrocardiographic abnormalities indicative of ischemic changes suggests a possible negative influence of diuretic-induced metabolic alterations on coronary heart disease in these patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000584:Amiloride / Q000009:adverse effects / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006977:Hypertension, Renal / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004338:Drug Combinations; D008055:Lipids; D014280:Triglycerides; D006852:Hydrochlorothiazide; D000584:Amiloride; D013999:Timolol; D002784:Cholesterol