The mycoplasmacidal effect of herbicolin A.
This study was to determine if the inhibitory effect of herbicolin A to sterol-requiring members of the class Mollicutes is due to a mycoplasmastatic or a mycoplasmacidal effect. Two strains were used as test organisms, Mycoplasma capricolum (California kid) and Ureaplasma urealyticum (T-960). Following exposure of the mycoplasmas to various inhibitory concentrations of herbicolin A for various periods of time, elimination of the antibiotic as a preliminary to demonstration of any surviving organisms was endeavoured by three different procedures: (a) serial dilution, (b) filtration through a membrane filter, and (c) separation of the organisms by centrifugation. The results of these experiments showed a mycoplasmacidal effect of herbicolin A.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology; D013997:Time Factors; D014509:Ureaplasma / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003470:Culture Media; D009842:Oligopeptides; D010455:Peptides; C027099:herbicolin A