The effect of oral corticosteroid dosage on CT enhancing multiple sclerosis plaques.
Fifty high-dose delayed CT scans were performed on 36 patients with definite MS within 4 months of a clinical relapse. The number of enhancing lesions visualized was compared in patients being treated with high- or low-dose oral corticosteroids and untreated controls. High-dose oral corticosteroid treatment significantly but incompletely reduced enhancement of MS plaques. Lower doses were less effective, especially when the latter were given on alternate days.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
D011241:Prednisone