Monosodium L-glutamate-induced convulsions--II. Changes in catecholamine concentrations in various brain areas of adult rats.
Norepinephrine (NE) and dopamine (DA) levels in various brain regions were measured in a model of experimentally produced convulsions by monosodium L-glutamate (MSG) administration to adult rats. Stress by injection of all solutions produced a 60% decrease in NE level in forebrain, recovering its basal value at 15 min after injection. A significant reduction of brain NE and DA levels of MSG-injected animals was found in the preconvulsive stage, particularly in the forebrain. No significant variations in catecholamine levels were seen in brain stem and cerebellum as a result of MSG injection. It is suggested that the changes found in endogenous catecholamine concentration in the forebrain may play a physiological role in the mechanisms of production of convulsions in the MSG model.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005971:Glutamates / Q000494:pharmacology*; D007274:Injections, Intraperitoneal / Q000009:adverse effects; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D012970:Sodium Glutamate / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013312:Stress, Physiological / Q000378:metabolism
D005971:Glutamates; D004298:Dopamine; D012970:Sodium Glutamate; D009638:Norepinephrine