[Effect of pertussis vaccine on the functional activity of the peritoneal and splenic macrophages in 2 mouse strains genetically differing by the intensity of their immune response].
The immunostimulating effect of corpuscular pertussis vaccine on the antigen-presenting and bactericidal functions of peritoneal and splenic macrophages in CBA and C57BL/6 mice, differing in the intensity of immune response to sheep red blood cells and Salmonella typhimurium, has been studied. The study has revealed that the injection of pertussis vaccine alters the functional activity of the cells under study, the effect depending on the immunizing dose, the strain of mice and the time elapsed from the moment of immunization. Pertussis vaccine enhances the low capacity of macrophages for antigen presentation in C57BL/6 mice with low responsiveness and alters the resistance of peritoneal and splenic macrophages to the cytopathic action of salmonellae.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D001202:Ascitic Fluid / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008808:Mice, Inbred CBA / Q000276:immunology*; D010567:Pertussis Vaccine / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D010567:Pertussis Vaccine
Vliianie kokliushnoĭ vaktsiny na funktsional'nuiu aktivnost' peritoneal'nykh i selezenochnykh makrofagov dvukh liniĭ mysheĭ, geneticheski razlichaiushchikhsia po sile immunnogo otveta.