Lipid peroxidation and oxidation of several compounds by H2O2 activated metmyoglobin.
Activated metmyoglobin (MetMb) by H2O2 initiates oxidation of microsomal unsaturated fatty acids, beta-carotene and methional but not formate. Lipid peroxidation by activated MetMb was not inhibited by catalase. The activated species which initiates lipid peroxidation appears to be a porphyrin cation radical, PFeIV=O, and not a hydroxyl radical.
D000818:Animals; D002338:Carotenoids / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005561:Formates / Q000378:metabolism; D006420:Hemeproteins / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008786:Metmyoglobin / Q000494:pharmacology*; D008861:Microsomes / Q000378:metabolism; D009132:Muscles / Q000648:ultrastructure; D013053:Spectrophotometry; D014422:Turkeys
D005561:Formates; D006420:Hemeproteins; D008054:Lipid Peroxides; C030544:formic acid; D008786:Metmyoglobin; D002338:Carotenoids; D006861:Hydrogen Peroxide; D002374:Catalase