title: Lipid deposition in human tendon xanthoma.
abstract: Tendon xanthomas often accompany the rapidly progressive atherosclerosis that develops in patients with familial hypercholesterolemia. This report describes lipid accumulation, as studied histochemically, in an Achilles tendon xanthoma from a patient whose death was secondary to complications of familial hypercholesterolemia. Lipid was stained with oil red O and filipin dyes for detection of esterified and unesterified cholesterol, respectively. As in human atherosclerosis, unesterified cholesterol accumulated in the tendon predominantly in the extracellular space but separately from oil-red-O-stained lipid that accumulated both intra- and extracellularly. Deposition of unesterified cholesterol in human atherosclerotic lesions and tendon xanthomas is an interesting but as yet unexplained phenomenon.
mesh_terms: D000125:Achilles Tendon / Q000378:metabolism*; D000328:Adult; D001344:Autopsy; D001391:Azo Compounds; D002784:Cholesterol / Q000378:metabolism; D004396:Coloring Agents; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications; D050356:Lipid Metabolism; D009135:Muscular Diseases / Q000378:metabolism; D014973:Xanthomatosis / Q000378:metabolism*
chemical_list: D001391:Azo Compounds; D004396:Coloring Agents; D002784:Cholesterol; C011049:oil red O