title: Absence of autoantibodies against neurofilament proteins in the sera of scrapie infected mice.
abstract: Autoantibodies against neurofilament proteins were not detected in any of the sera from the following scrapie infected mice: 19 mice infected with scrapie agent 139A in pre-clinical stage, 32 histologically confirmed scrapie mice and other 12 clinical scrapie mice infected with various strains. The test sera were assayed against acetone-fixed central neuron cultures from fetal mice by indirect immunofluorescence and immunoperoxidase techniques. The negative result suggests that autoantibodies against neurofilament proteins do not play a role in the pathogenesis of scrapie.
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D007381:Intermediate Filament Proteins / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D051381:Rats; D012608:Scrapie / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007381:Intermediate Filament Proteins