Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline).
All four possible stereoisomers of cyclo(histidylproline) were individually synthesized, purified, and characterized. They were each tested for anorectic activity in rats with a free feeding paradigm over 24 h. Contrary to literature reports, none significantly reduced food intake at any time over the test period.
D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004435:Eating / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D010456:Peptides, Cyclic; D010879:Piperazines; D001839:Bombesin; C015924:histidyl-proline diketopiperazine