Congenital skeletal malformations induced by maternal ingestion of Conium maculatum (poison hemlock) in newborn pigs.
Skeletal malformations were induced in newborn pigs from gilts fed Conium maculatum seed or plant during gestation days 43 through 53 and 51 through 61. The teratogenic effects in groups dosed during gestation days 43 through 53 were more severe than those in groups dosed during the later period, with many newborn pigs showing arthrogryposis and twisted and malaligned bones in the limbs and with 1 pig showing scoliosis and deformity of the thoracic cage. The pigs born to gilts given C maculatum during gestation days 51 through 61 had excessive flexure primarily in the carpal joints, without scoliosis or bone malalignment in the limbs. The teratogenicity of poison hemlock depends on the alkaloid concentration and content. Based on the data presented, we speculate that gamma-coniceine is the teratogenic alkaloid in the poison hemlock fed to the gilts.
D000014:Abnormalities, Drug-Induced / Q000662:veterinary*; D000470:Alkaloids / Q000009:adverse effects*; D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000002:abnormalities*; D005260:Female; D010939:Plant Poisoning / Q000209:etiology / Q000662:veterinary*; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000209:etiology*
D000470:Alkaloids; C018372:Prostaforton