title: 239Plutonium-induced heritable translocations in male mice.
abstract: This study was conducted to estimate the frequency of transmitted reciprocal translocations per rad of exposure to alpha particles from [239Pu]citrate. Data indicate that the rate of induction of heritable translocations is related linearly to the duration of spermatogonia stem cell exposure. The estimated increase in heritable translocations per rad of exposure of the stem cell to alpha particles is in the range of 1.45-2.91 X 10(-5)/gamete.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000209:etiology* / Q000235:genetics; D025063:Chromosome Disorders; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007248:Infertility, Male / Q000209:etiology; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011005:Plutonium / Q000008:administration & dosage; D013093:Spermatogonia / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects; D014178:Translocation, Genetic
chemical_list: D011005:Plutonium