Disposition of cocaine in fatal poisoning in man.
A fatal case of intravenous (IV) cocaine administration is presented. Cocaine tissue concentrations (mg/kg) in descending order were: kidney, 26; spleen, 22; brain, 14; heart, 6.1; skeletal muscle, 6.1; lung, 3.4; liver, 1.6; and adipose, 1.0. Body fluid cocaine concentrations (mg/L) were: urine, 39; bile, 10; vitreous humor, 2.4; and blood, 1.8. These results are in excellent agreement with cocaine tissue distribution in the dog following IV administration and limited tissue data in previously reported cocaine fatalities in man.
D000328:Adult; D000818:Animals; D003042:Cocaine / Q000378:metabolism* / Q000506:poisoning; D004285:Dogs; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders; D014018:Tissue Distribution
D003042:Cocaine