Indomethacin in the treatment of proximal tubular acidosis.
Treatment of a 7-week-old black male who had proximal tubular acidosis with large doses of bicarbonate did not achieve correction of the acidosis and was accompanied by diarrhea. Addition of indomethacin therapy (2 mg/kg/day) was followed by correction of the acidosis and allowed a decrease in the dosage of alkali.
D000141:Acidosis, Renal Tubular / Q000188:drug therapy*; D000468:Alkalies / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D007687:Kidney Tubules, Proximal; D008297:Male
D000468:Alkalies; D007213:Indomethacin