The hemodynamic effects of the sclerosant sodium morrhuate in dogs.
The hemodynamic effects of systemic administration of 5 per cent sodium morrhuate was evaluated in normal dogs. Dogs in the control group were injected with 2 per cent benzyl alcohol with pH adjusted to 9.5. Animals injected with sodium morrhuate had a significant reduction in cardiac output, arterial blood pressure, portal vein and hepatic artery flows. These changes occurred primarily in the first 30 minutes of observation. In response to the reduction of the hepatic blood flow, there was an increase in portal vein pressure and resistance.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D005227:Fatty Acids / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006499:Hepatic Artery / Q000502:physiology; D008102:Liver Circulation / Q000187:drug effects; D011169:Portal Vein / Q000502:physiology; D011651:Pulmonary Artery / Q000502:physiology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012976:Sodium Morrhuate / Q000494:pharmacology*; D013997:Time Factors
D005227:Fatty Acids; D012976:Sodium Morrhuate