[Effect of arginine on the arginase activity and urea content of the brain and liver of rats acclimating to cold].
At cold stress (3 days exposition at 2--4 degrees C) the urea formation in rats brain and liver does not become more active, the content of extraerythrocytic hemoglobin and the total peroxydase activity increase in blood serum, the animals sensitivity to the action of hyperbaric oxygenation (HB0) grows. At cold adaptation (45 days at 2--4 degrees C) the urea content in tissues and the activity of arginase in liver increase, the concentration of extraerythrocytic hemoglobin and the total peroxydase activity normalize, animals become more resistant to HB0. Every day administration of arginine during 3-day cold effect makes the brain and liver arginase on 42 and 28% more active, increases the urea content on 26 and 19%, stabilizes the erythrocytic membranes. The animals protected by arginine against cold are more resistant to the action of HB0.
D000064:Acclimatization / Q000187:drug effects*; D000818:Animals; D001119:Arginase / Q000378:metabolism*; D001120:Arginine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003080:Cold Temperature; D006931:Hyperbaric Oxygenation; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism; D013997:Time Factors; D014508:Urea / Q000378:metabolism*
D014508:Urea; D001120:Arginine; D001119:Arginase
Vliianie arginina na aktivnost' arginazy i soderzhanie mocheviny v mozge i pecheni krys pri akklimatizatsii k kholodu.