[Laboratory methods of controlling the effectiveness of antibacterial therapy].
The serum antibacterial activity (SAA) against causative agent isolated after the use of antibiotics was studied in 68 patients with pyoseptic diseases. The SAA ranged from 1:2 to 1:512 and depended on the antibiotic sensitivity of the causative agents. Antibiotic therapy was effective, when the SAA was equal to 1:8-1:512. With the use of monotherapy the adequacy of the regimens was controlled by the relation between the maximal blood level of the antibiotic and its MIC for the causative agent. The favourable clinical effect of the treatment with aminoglycosides and beta-lactams corresponded to the SAA exceeding 4.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001770:Blood Bactericidal Activity / Q000187:drug effects; D002228:Carbenicillin / Q000627:therapeutic use; D002437:Cefazolin / Q000627:therapeutic use; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D012853:Sisomicin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000667:Ampicillin; D002228:Carbenicillin; D002437:Cefazolin; D012853:Sisomicin
Laboratornye sposoby kontrolia éffektivnosti antibakterial'noĭ terapii.