title: Studies on beta-lactam antibiotics VIII. Structure-activity relationships of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem- 4-carboxylic acids.
abstract: The synthesis, antimicrobial activity and oral absorptivity of 7 beta-[(Z)-2-carboxymethoxyimino-2-arylacetamido]-3-cephem-4- carboxylic acids are described. The [(Z)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyimino]acetyl group was selected as the most suitable 7-substituent from seven 7-acyl groups for our further investigation of orally active cephalosporins.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins