title: Study on the inhibition of adenosine deaminase.
abstract: 4(R)-(1-Hydroxyethyl)-5-methyl-1-beta-D-ribofuranosylimidazole (10), which contains only the asymmetric alcohol center of the diazepinol ring of the adenosine deaminase inhibitor coformycin (12), is a much less potent inhibitor of the enzyme but still binds to the enzyme about as tightly as the normal substrate.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D003070:Coformycin / Q000494:pharmacology; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D012263:Ribonucleosides / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D058892:Adenosine Deaminase Inhibitors; D012263:Ribonucleosides; D003070:Coformycin; C047244:(1-hydroxyethyl)-5-methyl-1-beta-ribofuranosylimidazole; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine