[Clinico-rheographic study of the cerebrovascular effect of alpha-adrenergic blockers in vascular diseases of the brain].
The effect of the alpha-adrenoblockers, nicergoline (N) and dihydroergotoxin (DHET), on the cerebral vessels and the systemic hemodynamics was studied in 152 patients with acute and chronic vascular diseases of the brain. It was established that the hypotensive action of alpha-blockers was the greater the higher was the initial arterial hypertension. REG conducted during an hour after the intravenous administration of N and DHET revealed an increase in the pulse blood filling and an improvement of the arterial tone. Changes in vascular resistance were heterogeneous. Both drugs induced the venous outflow but there were no signs of venous hypotension. An improvement in the systemic and cerebral hemodynamics correlated with clinical improvement.
D001794:Blood Pressure; D002545:Brain Ischemia / Q000188:drug therapy; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D004088:Dihydroergotoxine / Q000627:therapeutic use*; D004873:Ergolines / Q000627:therapeutic use*; D006801:Humans; D009530:Nicergoline / Q000627:therapeutic use*; D010992:Plethysmography, Impedance; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy; D014655:Vascular Resistance
D004873:Ergolines; D004088:Dihydroergotoxine; D009530:Nicergoline
Kliniko-reograficheskoe issledovanie tserebrovaskuliarnogo éffekta al'fa-adrenergicheskikh blokatorov pri sosudistykh zabolevaniiakh golovnogo mozga.