title: Gyrate atrophy of choroid and retina complicated by vitreous hemorrhage.
abstract: We describe two patients with gyrate atrophy of the choroid and retina who suffered from vitreous hemorrhages in adolescence. The diagnosis of gyrate atrophy was confirmed biochemically and clinically; hyperornithinemia and a deficiency of ornithine ketoacid transaminase were confirmed biochemically. Typical fundus changes of scalloped chorioretinal atrophies with sharp margins, deteriorated dark adaptation, non-recordable electroretinogram, flat electrooculogram, and constricted visual fields were noted. We believe that the vitreous hemorrhage is an ocular complication in this disorder.
mesh_terms: D000328:Adult; D001284:Atrophy / Q000097:blood / Q000150:complications / Q000235:genetics; D002648:Child; D002829:Choroid / Q000473:pathology*; D005128:Eye Diseases / Q000150:complications; D005260:Female; D005451:Fluorescein Angiography; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D008297:Male; D009952:Ornithine / Q000097:blood; D012008:Recurrence; D012160:Retina / Q000473:pathology*; D014822:Vitreous Body
chemical_list: D009952:Ornithine