title: Immune responses to late booster doses of hepatitis B vaccine.
abstract: Nineteen healthy young adults were vaccinated with plasma-derived hepatitis B vaccine at months 0, 1, and 12, and their immune responses were compared to those of a similar group of 20 vaccinees immunized at months 0, 1, and 6. Late booster injections at 12 months produced nearly fivefold higher geometric mean anti-HBs levels than those of the control group. The higher anti-HBs values may lead to longer persistence of anti-HBs and thus to longer protection against hepatitis B.
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D007167:Immunotherapy; D008297:Male; D013997:Time Factors; D014611:Vaccination
chemical_list: D006514:Hepatitis B Surface Antigens