title: [An undesirable drug interaction in horses? Complications which can occur during the administration of coumarin derivatives and phenylbutazone].
abstract: A study of the literature was done because of questions asked in a court of justice concerning possible poisoning in a jumper, resulting from administration of both phenylbutazone and a coumarin derivative within a particular period. In view of the mechanisms of action and the pharmacokinetic characteristics of the agents, these forms of combined treatment are also highly inadvisable in horses.
mesh_terms: D000818:Animals; D003374:Coumarins / Q000506:poisoning*; D004285:Dogs; D004347:Drug Interactions; D006734:Horse Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006736:Horses; D010653:Phenylbutazone / Q000506:poisoning*; D014812:Vitamin K / Q000627:therapeutic use
chemical_list: D003374:Coumarins; D014812:Vitamin K; D010653:Phenylbutazone
vernacular_title: Een ongewenste interactie van geneesmiddelen bij het paard? Complicaties, die tijdens de toepassing van cumarine-derivaten en fenylbutazon kunnen optreden.