title: Malignant histiocytosis appearing as cold-agglutinin disease.
abstract: We have described a 63-year-old man with elevated titers of cold agglutinins who was found to have malignant histiocytosis. Treatment with cytotoxic agents resulted in a rapid though temporary clinical response. Malignant histiocytosis should be considered in patients with unexplained cold agglutinin disease.
mesh_terms: D000373:Agglutinins / Q000032:analysis; D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D003450:Cryoglobulins; D003937:Diagnosis, Differential; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D000373:Agglutinins; D003450:Cryoglobulins; C029443:cold agglutinins