Trehalose dimycolate from various mycobacterial species induces differing anti-infectious activities in combination with muramyl dipeptide.
Significant resistance against influenza virus and Mycobacterium tuberculosis infections was induced when trehalose dimycolate from M. tuberculosis or M. bovis but not M. avium was combined with muramyl dipeptide. Trehalose dimycolate from M. tuberculosis, in contrast to that from M. avium, could confer resistance against Toxoplasma gondii infections.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage*; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D003311:Cord Factors / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D006017:Glycolipids / Q000008:administration & dosage*; D051379:Mice; D009161:Mycobacterium / Q000032:analysis*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003311:Cord Factors; D004338:Drug Combinations; D006017:Glycolipids; D000119:Acetylmuramyl-Alanyl-Isoglutamine