Cortical serotonin receptor subtypes after lesion of ascending cholinergic neurones in rat.
Serotonin (5-HT) S1 and S2 receptors were studied in rat cortex after lesion of the ascending cholinergic systems by injection of ibotenic acid into the nucleus basalis. The lesions produced a large (56%) decrease in choline acetyltransferase activity with no change in markers of gamma-aminobutyric acid, dopamine and 5-HT containing neurones. Lesions of the ascending cholinergic neurones were accompanied by a loss of 5-HT S1 receptor binding sites with no change in S2 receptors. These results suggest that a proportion of S1 receptors may be associated with cholinergic terminals.
D000818:Animals; D001479:Basal Ganglia; D001927:Brain Diseases / Q000139:chemically induced / Q000378:metabolism; D002540:Cerebral Cortex / Q000032:analysis* / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers; D007051:Ibotenic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000032:analysis*; D013377:Substantia Innominata
D011985:Receptors, Serotonin; D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase