title: [Experiences with propranolol (Obsidan25) in hypertension therapy in pregnancy].
abstract: The treatment of the mentioned forms of hypertension with propranolol during pregnancy either as monotherapy or in combination with dihydralazine and after careful exclusion of the contraindications described represents a further effective therapy. In the control examinations during pregnancy carried out in close cooperation between obstetrician and internist no detrimental side effects could be established for both mother and child. No significant changes of absorption, distribution and elimination of propranolol in pregnant women with hypertension in comparison with normotensive nonpregnant women were found as follows from the pharmacokinetic parameters shown.
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D004078:Dihydralazine / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D007700:Kinetics; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011433:Propranolol / Q000378:metabolism / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D011433:Propranolol; D004078:Dihydralazine
vernacular_title: Erfahrungen mit Propranolol (Obsidan25) in der Hochdrucktherapie bei Schwangeren.