title: Frontal subcutaneous blood flow, and epi- and subcutaneous temperatures during scalp cooling in normal man.
abstract: Cooling of the scalp has been found to prevent hair loss following cytostatic treatment, but in order to obtain the hair preserving effect the subcutaneous temperature has to be reduced below 22 degrees C. In order to establish the relationship between epicutaneous and subcutaneous temperatures during cooling and rewarming and to measure the effect of scalp cooling on subcutaneous scalp blood flow, subcutaneous blood flow and epi- and subcutaneous temperatures were measured in the frontal region at the hairline border before and during cooling with a cooling helmet, during spontaneous rewarming of the cooling helmet and after removal of the rewarmed helmet in 10 normal subjects. Subcutaneous blood flow was reduced to about 25% of the postcooling control level during cooling. The flow was constantly reduced until the subcutaneous temperature exceeded 30-32 degrees C. A linear relationship between epicutaneous and subcutaneous temperatures could be demonstrated with the regression equation: s = 0.9 c + 4.9 (r = 0.99). In eight of the 10 subjects the subcutaneous temperature could be reduced below 22 degrees C with the applied technique. It is concluded that the hair preserving effect of scalp cooling during cytostatic treatment is mainly due to the metabolic effect of cooling, and only to a minor extent due to the flow reducing effect.
mesh_terms: D000328:Adult; D000505:Alopecia / Q000139:chemically induced / Q000517:prevention & control; D000970:Antineoplastic Agents / Q000009:adverse effects; D001831:Body Temperature; D003080:Cold Temperature; D005260:Female; D006801:Humans; D008297:Male; D012039:Regional Blood Flow; D012535:Scalp / Q000098:blood supply*; D014980:Xenon Radioisotopes
chemical_list: D000970:Antineoplastic Agents; D014980:Xenon Radioisotopes