[Effect of combined treatment with cisplatin and irradiation on the survival of kidney cells in the Syrian hamster].
During combined treatment of hamster kidney cells with cisplatin and irradiation under aerobic conditions, there appear interactions between the two treatment modalities. The presence of cisplatin during irradiation leads to an increased bending, pretreatment or posttreatment with cisplatin to a gradual adaption of the shape of the survival curve to a straight line. Simultaneous treatment of hamster kidney cells with cisplatin and irradiation in hypoxia does not change the survival curve in contrast to simultaneous treatment under aerobic conditions.
D000818:Animals; D002470:Cell Survival; D002945:Cisplatin / Q000494:pharmacology*; D006224:Cricetinae; D004307:Dose-Response Relationship, Radiation; D000860:Hypoxia / Q000503:physiopathology; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*
D002945:Cisplatin
Der Effekt einer kombinierten Behandlung mit Cisplatin und Bestrahlung auf das Uberleben von Nierenzellen des syrischen Hamsters.