[Mechanism of enzymatic imprinting induced in rats by an early postnatal administration of galactose].
Administration of galactose into young rats within an early postnatal period led to alteration in activity of some enzymes involved in utilization of galactose (galactose-1-phosphaturidyl transferase, galactose-6-phosphate dehydrogenase etc) for a long period of the animals life. This stable alteration in activity of adaptive enzymes was characterized as the enzymatic imprinting. After administration of galactose into neonatal animals synthesis of RNA, matrix activity of chromatin, activities of DNA-dependent RNA polymerase and RNA-dependent DNA polymerase were shown to increase in liver tissue of these animals. These alterations are considered as a possible basis for the stable alterations in the genes expression. The elevated activities of DNA-dependent RNA-polymerase and reverse transcriptase were maintained within a long period of the animals life.
D000818:Animals; D000831:Animals, Newborn; D004247:DNA / Q000096:biosynthesis; D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis / Q000235:genetics; D004790:Enzyme Induction / Q000187:drug effects; D005690:Galactose / Q000494:pharmacology*; D005693:Galactosemias / Q000201:enzymology* / Q000235:genetics; D005786:Gene Expression Regulation; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis / Q000235:genetics; D008099:Liver / Q000201:enzymology; D051381:Rats; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000037:antagonists & inhibitors / Q000235:genetics
D004247:DNA; D005954:Glucosephosphate Dehydrogenase; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase; D012321:DNA-Directed RNA Polymerases; D005690:Galactose
Izuchenie mekhanizma fermentativnogo imprintinga, indutsirovannogo u krys rannim postnatal'nym vvedeniem galaktozy.