Synthesis and spectroscopic and fungicidal characterization of hydroxamic acids and their metal chelates.
Hydroxamic acid chelates of the type ML2, ML2', and ML2" where M = Cu(II), Ni(II) or Co(II) and L = N,2'-diphenylacetohydroxamic acid (N,2'-DPAHA), L' = 2,2'-diphenylacetohydroxamic acid (2,2'-DPAHA), and L" = 2-phenylacetohydroxamic acid (2-PAHA) have been isolated and characterized on the basis of elemental analysis and infrared and magnetic data. These metal chelates were screened for their fungicidal activity. The testing against fungi has been carried out by slide germination technique against Alternaria alternata and by inhibition zone technique against Fusarium oxysporum and Aspergillus flavus. The fungicidal activity of chelates and their parent ligand has been compared with the commercial fungicide, Dithane M-45, screened under similar conditions.
D000935:Antifungal Agents; D002614:Chelating Agents; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects*; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D002614:Chelating Agents; D006877:Hydroxamic Acids; D007202:Indicators and Reagents