Results of radiation treatment of medulloblastoma in adults.
From 1961 to 1982, 20 adults (greater than 16 years of age) were treated with radiation therapy following surgery for medulloblastoma. All patients received neuro-axis irradiation. Five patients received adjuvant chemotherapy. A 5- and 10-year survival rate of 78 and 55%, respectively, were achieved. Treatment failures were mainly a result of local recurrences, but also of metastases. One patient died of acute myeloid leukemia. One patient developed paraplegia. The survival rate was better in males (2 deaths out of 14) than in females (5 deaths out of 6). All the survivors are free of deficit or sequelae, except the patient with paraplegia.
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000556:secondary; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008527:Medulloblastoma / Q000401:mortality / Q000532:radiotherapy*; D012189:Retrospective Studies; D012737:Sex Factors; D013120:Spinal Cord Neoplasms / Q000556:secondary; D013997:Time Factors