Effect of diazepam on drug absorption and gastric emptying in man.
Paracetamol 20 mg kg-1 dissolved in 200 ml of water was given by mouth to seven healthy volunteers, together with a single i.v. dose of diazepam 0.2 mg kg-1 or saline 0.04 ml kg-1. This study demonstrated that the rate of paracetamol absorption was not significantly changed by diazepam, indicating that there was no delay in gastric emptying attributable to diazepam per se.
D000082:Acetaminophen / Q000097:blood / Q000378:metabolism; D000328:Adult; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D013997:Time Factors
D000082:Acetaminophen; D003975:Diazepam