Suppression of human lymphocyte mitogen response by retroviruses of type D. II. Non-activity of Mason-Pfizer monkey virus versus activity of human cell line derived virus PMFV.
In contrast to the human cell line derived type D retrovirus PMFV, the Mason-Pfizer monkey virus (MPMV) does not suppress the mitogen response of normal human lymphocytes. Both viruses have been propagated on the same cell lines and purified by the same methods. MPMV did not contain a factor able to abolish PMFV-induced suppression of the mitogen response. Neither could MPMV suppress the mitogen response of lymphocytes from rhesus monkeys or baboons. PMFV however inhibited their reactivity.
D000818:Animals; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000302:isolation & purification; D008213:Lymphocyte Activation; D008251:Macaca; D012190:Retroviridae / Q000032:analysis / Q000276:immunology*
D007166:Immunosuppressive Agents; D003208:Concanavalin A