Immediate and long-term effects of halothane anesthesia on equine platelet function.
The acute and long-term quantitative and qualitative effects of halothane anesthesia on equine platelet performance were studied in fourteen horses. Horses were anesthetized with only halothane in O2 for about 8.0 MAC hours. Platelet numbers declined during the anesthetic period but returned to normal within 24 h. Platelet aggregation was significantly diminished during the anesthetic period and for up to 4 days after anesthesia. A period of hyperaggregability occurred at the 7th day.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000769:Anesthesia, Inhalation / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology; D006221:Halothane / Q000009:adverse effects; D006736:Horses / Q000097:blood*; D066298:In Vitro Techniques; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects
D000244:Adenosine Diphosphate; D003094:Collagen; D006221:Halothane