Vinblastine blocks stimulation-dependent vesicle redistribution in incubated synaptosomes.
Rat cortical synaptosomes were depolarized by the addition of protoveratrine to the incubating medium. The resulting synaptic vesicle aggregation near the synaptic cleft was prevented by vinblastine. Electron microscopy of both routine- and phosphotungstic acid-treated materials suggests the involvement of cytoskeletal structures in stimulation-dependent vesicle redistribution.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D003599:Cytoskeleton / Q000187:drug effects; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D011526:Protoveratrines / Q000037:antagonists & inhibitors; D051381:Rats; D013572:Synaptic Vesicles / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects* / Q000648:ultrastructure; D014747:Vinblastine / Q000494:pharmacology*
D011526:Protoveratrines; D014747:Vinblastine