Monoclonal antibody-mediated enhancement of growth hormone activity in vivo.
This work demonstrates that complexing hGH with monoclonal antibody EBl (MAB-EBl) can produce a striking potentiation of the somatogenic actions of hGH in vivo in Snell dwarf mice. In short-term experiments significant increases in cartilage metabolism and body weight were noted; these responses were dose-dependent for both MAB-EBl and hGH concentration. Increased growth was also observed in long-term experiments. In marmosets where MAB-EBl cross-reacts with endogenous GH, MAB-EBl alone enhanced the actions of endogenous GH. A new perspective may be necessary to incorporate these results into the current concept of antibody action.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002356:Cartilage / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D006128:Growth / Q000187:drug effects*; D013006:Growth Hormone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D013997:Time Factors
D000911:Antibodies, Monoclonal; D013006:Growth Hormone