title: Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility.
abstract: The influence of several nootropic drugs (piracetam, pyritinol, meclofenoxat, methylglucamine orotate (MGO) and dihydroergotoxine (DHET) on both the ethanol preference and the enhanced seizure susceptibility after a single dose of ethanol was studied. Piracetam, MGO and DHET reduce the ethanol drinking in ethanol-preferring mice. The enhanced seizure susceptibility after a single dose of ethanol was abolished by piracetam and MGO.
mesh_terms: D000428:Alcohol Drinking; D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009963:Orotic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013569:Synapses / Q000187:drug effects; D014192:Trapidil / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: C046930:AR 12456; D004088:Dihydroergotoxine; D000431:Ethanol; C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine; D014192:Trapidil; D010889:Piracetam