The effects of pre-enucleation irradiation on the development of metastases from intraocular Greene melanoma in hamsters.
Using intraocular Greene melanoma in a hamster model, we studied the effect of pre-enucleation irradiation on the development of melanoma metastases. One group (No. = 111) was treated with 1,210 to 1,600 rads of cobaltous chloride Co 60 gamma irradiation before enucleation and the second group (No. = 100) received no irradiation. The groups did not differ with respect to presence of metastases in the 106 days after tumor implantation (chi 2 = 3.05; P = .08). However, Kaplan-Meier survival curves gave a longer time to melanoma-related death in the irradiated animals compared with the controls (log rank test, P = .0008).
D000818:Animals; D006224:Cricetinae; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D008647:Mesocricetus; D011182:Postoperative Care; D011300:Preoperative Care; D014604:Uveal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary