Evaluation of the value of fluorometric serum heat stable alkaline phosphatase assay in patients operated on for ovarian tumors.
The usefulness of a simple fluorometric assay for serum heat-stable alkaline phosphatase (HSAP) in the diagnosis and follow-up of ovarian cancer patients was evaluated. 50 percent of the patients with malignant ovarian tumors had serum HSAP-activities above the upper reference range. Active production of this tumor marker in malignant but not in benign ovarian tumors was demonstrated by analysing serum HSAP-activities in ovarian vein blood. After operation, serum HSAP-activities decreased in all cancer patients with elevated preoperative values. Our results suggest that fluorometric serum HSAP-assay may be a useful alternative method for the determination of this tumor marker especially in a clinical laboratory.
D000469:Alkaline Phosphatase / Q000097:blood*; D005069:Evaluation Studies as Topic; D005260:Female; D005470:Fluorometry; D005500:Follow-Up Studies; D006358:Hot Temperature; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000601:surgery; D010053:Ovary / Q000098:blood supply
D000469:Alkaline Phosphatase