[Quantitative immunoenzyme determination of the lactoferrin and alpha-lactalbumin in the blood serum of cancer patients].
An enzyme-linked immunosorbent assay (ELISA) has been used for quantitative determination of lactoferrin (Lf) and alpha-lactalbumin (alpha-La) in human blood serum. The mean concentration of Lf in normal serum was 265 +/- 21 ng/ml and that of alpha-La did not exceed 5 ng/ml. The increased Lf level (above 450 ng/ml) was found in 16 of 30 (53%) patients with gastrointestinal cancer, in 11 of 25 (44%)--with lung cancer, in 13 of 42 (31%)--with breast cancer and more rarely--in other cancer patients. The increased alpha-La level (above 5.0 mg/ml) was found in 5 of 42 patients with breast cancer and very rarely--in other cancer patients. A conclusion is drawn that serological measurements of Lf and alpha-La were of no diagnostic value for breast cancer.
D001782:Blood Donors; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007768:Lactalbumin / Q000097:blood*; D007781:Lactoferrin / Q000097:blood*; D007782:Lactoglobulins / Q000097:blood*; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis
D007782:Lactoglobulins; D007768:Lactalbumin; D007781:Lactoferrin
Kolichestvennoe immunofermentativnoe opredelenie laktoferrina i al'fa-laktal'bumina v syvorotke krovi onkologicheskikh bol'nykh.