Maternal to fetal movement of creatinine as a measure of perfusion efficiency and diffusional transfer in the isolated human placental lobule.
A method employing the maternal to fetal transfer of the slowly diffusing molecule creatinine in the closed-circuit dual perfusion of a term human placental lobule is described. This molecule provides an alternative to the use of antipyrine and is a useful tool in determining the overlap of the two circulations and the available exchange area in this preparation.
D000983:Antipyrine; D003404:Creatinine; D004058:Diffusion; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D010477:Perfusion; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy
D003404:Creatinine; D000983:Antipyrine