[Combined chemotherapy of advanced soft tissue sarcomas using the platinum derivative cisplatin (platidiam)].
The results of treatment of 69 cases of advanced soft tissue sarcomas are presented. Patients were given various drug schemes including cisplatin. Overall response in the study group was 30%. Tumor appeared sensitive to the treatment in 49%. A combination of carminomycin, methotrexate, cyclophosphamide and cisplatin proved to be the most effective (39%). The scheme was effective in both untreated patients and those previously treated with adriamycin. Hematologic toxicity registered in 67% cases was the most severe complication involved in the treatment with the above drug regimen.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D004351:Drug Resistance; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology
D002945:Cisplatin
Kombinirovannaia khimioterapiia rasprostranennykh form sarkom miagkikh tkaneĭ s ispol'zovaniem proizvodnogo platiny-tsisplatiny (platidiama).