title: [Clinico-experimental studies of therapy optimization in kidney tuberculosis].
abstract: The use of antituberculotic short-term chemotherapeutic methods did not yet make its way on a larger scale in the treatment of the extrapulmonary tuberculosis on account of supposed peculiarities of the terrain. Therefore, the present clinical and experimental study had the aim to investigate the distribution of INH and RMP in the kidney and the radiometrical determination of their concentration directly in the tuberculous focus of the kidney. For this purpose the tritium labelling of the two basis antituberculotics mentioned was carried out. Apart from the description of the applied working and measuring technique, questions of the distribution of medicaments are discussed. The results made evident that also in kidneys widely destroyed by tuberculosis both INH after an intravenous application of 300 mg and RMP after oral application of 600 mg even in large tuberculous caverns achieve antimycobacterially effective concentrations. Indeed, there are considerable differences, however, the values were always far above the minimum inhibition concentration. Thus there are no terrain-caused peculiarities for the tuberculous kidney and also no restrictions as to the use of an optimized antituberculotic chemotherapy. The same is probably also applied to all other forms of the extrapulmonary tuberculosis. The newly developed method distinguishes itself by a high measuring exactness and could analogously be used in questions of the chemotherapy of malignant tumours.
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000378:metabolism / Q000627:therapeutic use*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000378:metabolism / Q000627:therapeutic use*; D014398:Tuberculosis, Renal / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D007538:Isoniazid; D012293:Rifampin
vernacular_title: Klinisch-experimentelle Untersuchungen zur Therapieoptimierung der Nierentuberkulose.