title: Effect of aspiration of cerebro-spinal fluid on spinal anaesthesia with isobaric 0.5% bupivacaine.
abstract: The effect of changing the volume of cerebro-spinal fluid (CSF) before spinal anaesthesia with 3 ml of isobaric 0.5% bupivacaine was investigated in 60 elderly (58-77 years) orthopaedic or urological patients. The patients were randomly allocated to three groups. They received the spinal anaesthetic either with or without the aspiration of 3 ml of CSF. In the third group a mixture of 3 ml of aspirated CSF and 3 ml of 0.5% isobaric bupivacaine was given. Pin-prick analgesia and motor block were tested during the induction and recovery. The only statistically significant difference between the groups was in the time-lag from administration to maximum spread of pin-prick analgesia, which was shortest in the group without aspiration (mean 19.5 min, other groups 29-30 min). The mean maximum level of analgesia was T6-T7 in each group. The anaesthesia was satisfactory in most cases. One death occurred because of a massive pulmonary embolism. The clinical significance of aspirating CSF before attempting spinal anaesthesia with 3 ml of 0.5% isobaric bupivacaine was found to be small.
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage*; D002555:Cerebrospinal Fluid; D005260:Female; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D012677:Sensation; D013396:Suction
chemical_list: D002045:Bupivacaine