Iron deficiency protects inbred mice against infection with Plasmodium chabaudi.
Plasmodium chabaudi infections of NFR/N mice made anemic by dietary iron deficiency produced mortalities of 25% (male) and 7% (female) compared with 100% in iron-sufficient controls. When iron-deficient mice convalescing from the primary infection were returned to the normal diet, 100% experienced recrudescent parasitemia. No recrudescence occurred in mice maintained on the iron-deficient diet.
D000747:Anemia, Hypochromic / Q000469:parasitology; D000818:Animals; D005260:Female; D007501:Iron / Q000494:pharmacology; D000090463:Iron Deficiencies; D008288:Malaria / Q000097:blood*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010961:Plasmodium / Q000254:growth & development
D007501:Iron