Mouse phenotype modulates the behavioral effects of acute thiamine deficiency.
The influence of mouse phenotype on the behavioral effects of thiamine deficiency was examined in three experiments. A reduction in spontaneous motor activity occurring during acute thiamine deprivation was found to be greater in C57 mice than in Balb and Nylar mice. No persistent post-deprivation effects were observed nor were there any changes in Y-maze alternation or spatial discrimination learning. These results provide a further demonstration of genetic-environmental interactions in determining pathological behavioral states.
D000208:Acute Disease; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D005106:Exploratory Behavior; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009043:Motor Activity; D010641:Phenotype; D013045:Species Specificity; D013832:Thiamine Deficiency / Q000235:genetics*