Subcellular distribution of [125I]iodoaryl beta-methyl fatty acids.
Subcellular distribution studies of two aryl branched-chain and one aryl straight-chain iodinated fatty acids were carried out as part of a continuing effort to determine if such acids are metabolized by beta-oxidation. For the omega-iodoaryl fatty acids, a change in subcellular radioactivity location was observed which was chain-length dependent. Chain lengths of 15 carbons, straight and branched, were largely found in the nuclear-membrane fraction, whereas a chain length of 8 carbons was largely located in the cytosol. No unequivocal evidence for metabolic trapping in the mitochondria was observed for omega-iodoaryl branched-chain fatty acids using the centrifugation technique employed in this study.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000378:metabolism
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes