title: Patient comfort and plasma lignocaine concentrations during fibreoptic bronchoscopy.
abstract: In a preliminary prospective study, eleven outpatients undergoing fibreoptic bronchoscopy using a titrated dose of topical lignocaine anaesthesia were studied. Patient comfort, lignocaine dosage and resultant plasma concentrations were measured at four stages during the procedure. Large total doses, mean 512 (SD 55) mg lignocaine, were frequent and systemic absorption was unpredictable with two patients having plasma concentrations in the toxic range (greater than 5 micrograms/ml). Peak plasma concentrations, mean 2.3 (SD 1.4) micrograms/ml, occurred 30 to 40 minutes after commencement of topical application and coincided with completion of the procedure. No correlation was found between the individual dose of lignocaine administered and either the resultant plasma concentration or patient comfort scores. In an effort to minimise potential lignocaine toxicity, a fixed total dose technique (lignocaine 370 mg) was studied in a further twenty-one patients. No change in patient comfort scores and no toxic plasma concentrations were observed. Mean completion plasma concentration was 2.0 (SD 1.0) micrograms/ml. No clinical toxicity was observed in either group. Fibreoptic bronchoscopy in both groups using topical lignocaine anaesthesia without premedication or intravenous supplementation was well tolerated.
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000336:Aerosols; D001999:Bronchoscopy / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000097:blood
chemical_list: D000336:Aerosols; D008012:Lidocaine