Dose-related physostigmine-induced ventricular arrhythmia: case report.
Physostigmine, a centrally-acting cholinesterase inhibitor, has been shown to have potential as a treatment for primary degenerative dementia. In an experiment to test its effects, i.v. physostigmine caused the onset of unifocal premature contractions and runs of bigeminy in an 85-year-old man.
D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy; D010830:Physostigmine / Q000009:adverse effects*; D010919:Placebos
D010919:Placebos; D010830:Physostigmine