Response to pneumococcal vaccination in normal and post-infected Nigerians.
Twelve patients who had recovered from pneumococcal infections and 12 household controls were given a polyvalent pneumococcal vaccine. Adequate amounts of antibody were detected by radioimmunoassay before immunisation in controls and patients. More controls responded to nine pneumococcal polysaccharides than did patients. A transient state of unresponsiveness to vaccine may exist in some patients for a period of 4-6 weeks after infection. The high concentrations of antibody before immunisation in adult controls suggest adequate herd immunity to the endemic serotypes in the adult population.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008586:Meningitis, Pneumococcal / Q000276:immunology; D009549:Nigeria; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D011018:Pneumonia, Pneumococcal / Q000276:immunology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000276:immunology; D014611:Vaccination
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M