title: Application of a vascular graft material (Solcograft-P) in experimental surgery.
abstract: The implantation and post-implantation behaviour of a Solcograft-P vascular prosthesis in the aortic, aorto-iliac, carotid and vena caval positions in dogs was studied up to 100 d post-surgery in order to assess the suitability of this vascular material for use in man. Solcograft-P is prepared from the carotid arteries of calves by crosslinking the collagen stroma using adipyl dichloride. During the postoperative follow-up period of 3 month, 100% of the aortal grafts, 80% of the aorto-iliac bypasses, 60% of the vena caval grafts and 35% of the carotid implants remained patent. The biochemical properties of the Solcograft-P are better than those of Solcograft, its predecessor. The intimal lining was consistently smooth and homogeneous in grafts of biological origin, and no aneurysm was observed. Infection and early thrombosis occured no more frequently than with other grafts. The new Solcograft-P, crosslinked via ester and amide groups, seems to represent a real improvement over Solcograft. Our results suggest that Solcograft-P should prove valuable in various cases of reconstructive vascular surgery of the lower limb, especially when the autologous vena saphena magna is not available, and its mechanical properties may well prove suitable for both arterial and venous replacement.
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001807:Blood Vessel Prosthesis; D003094:Collagen / Q000031:analogs & derivatives* / Q000276:immunology; D004285:Dogs; D004548:Elasticity; D004727:Endothelium / Q000648:ultrastructure; D005069:Evaluation Studies as Topic; D005260:Female; D006083:Graft Occlusion, Vascular / Q000473:pathology; D008297:Male
chemical_list: C024155:Solcograft; D003094:Collagen