title: Effect of lymphocytapheresis plus cyclophosphamide on the course of a chronic progressive form of multiple sclerosis.
abstract: We report a case of a 16 year old boy with a chronic progressive form of Multiple Sclerosis treated with lymphocytapheresis and a low dose regimen of cyclophosphamide. A progressive improvement in the disability index and slowing of the clinical course were obtained. No side effects were observed. Depletion of lymphocytes and their pharmacological suppression point to their possible role in the induction of an immunoregulation of the disease process.
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004185:Disability Evaluation; D006801:Humans; D007937:Leukapheresis; D008297:Male; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D003520:Cyclophosphamide