Derivatives of benzo(c)fluorene. XVI. Absorption, distribution and elimination of 3H-benflurone, 5-(2-N,N-dimethylamino)ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride in rats after oral and intravenous administration.
3H-benfluorone administered orally to rats, persists for a long time in the stomach; it is absorbed only partly and eliminated mostly through the feces (about 80% within 7 days). The maximum levels in the blood and the organs were determined in the 1st and 9th hour after application. Benflurone penetrates through the placentary barrier. Within one week 13% of the administered radioactivity was eliminated through the urine and 8% through the bile within 12 h. It has been demonstrated that benflurone was excreted through the milk, as well. After being administered intravenously, benflurone moves quickly from the blood into the tissues. The high levels were recorded in the heart, the lungs, the kidneys, the brain and the liver. After intravenous application about 70% of the administered radioactivity was eliminated within one week through the feces and about 24% through the urine, almost 54% through the bile within 12 h.
D000284:Administration, Oral; D000818:Animals; D005260:Female; D005449:Fluorenes / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D008431:Maternal-Fetal Exchange; D008892:Milk / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D005449:Fluorenes; C034234:VUFB 13468