Myoclonus, hyperreflexia and diaphoresis in patients on phenelzine-tryptophan combination treatment.
Three cases are presented on patients on an MAOI who developed a transient syndrome of myoclonus, hyperreflexia, jaw quivering, teeth chattering and diaphoresis after L-Tryptophan was added. Caution is advised when considering the addition of a serotonergic agent to MAOI's.
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects; D009207:Myoclonus / Q000139:chemically induced*; D010624:Phenelzine / Q000009:adverse effects*; D012021:Reflex, Abnormal / Q000139:chemically induced*; D013577:Syndrome; D014364:Tryptophan / Q000009:adverse effects*
D000929:Antidepressive Agents, Tricyclic; D008996:Monoamine Oxidase Inhibitors; D014364:Tryptophan; D010624:Phenelzine