A solid virilizing granulosa cell tumour.
Clinical signs of virilization in patients with granulosa cell tumours are reported in approx. 2% of the cases, but hormonal investigation has been rarely performed. We present the clinical, histological and hormonal data obtained in a premenopausal, amenorrhoeic woman, with a testosterone-producing granulosa cell tumour. Based on the peripheral-ovarian hormone gradients, the biosynthetic pathway of steroidogenesis in this case is discussed.
D000328:Adult; D000735:Androstenedione / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000150:complications*; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications*; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000097:blood / Q000209:etiology*
D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D004958:Estradiol