Short-term effects of prolactin on prostatic function in rats with lisuride-induced hypoprolactinaemia.
The effects of a single injection of ovine prolactin on prostatic function were monitored in intact, intact androgenized and castrated-androgenized rats rendered hypoprolactinaemic after 7 days of treatment with a potent dopamine agonist, lisuride. Hypoprolactinaemia was associated with reductions in ventral prostate weight, polyamine levels, lateral lobe zinc and the concentration of the ventral prostate protein prostatein, but an elevation in the level of cytosolic oestradiol binding. Whether these differences attained statistical significance depended on whether the animals were intact, intact-androgenized or castrated-androgenized. With the exception of ventral prostate weight and lateral lobe zinc concentrations, a single injection of prolactin restored or reversed these changes towards control levels within 12 h, which could not be explained by an indirect effect of the hormone on adrenal or testicular function. No effects of lisuride or prolactin were observed with regard to the content of fructose in the coagulating gland or in the degree of prolactin binding to prostatic membranes.
D000727:Androgen-Binding Protein / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm; D003600:Cytosol / Q000378:metabolism; D004873:Ergolines / Q000494:pharmacology*; D004958:Estradiol / Q000378:metabolism; D008090:Lisuride / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D011388:Prolactin / Q000097:blood / Q000494:pharmacology*; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D060789:Prostatein; D051381:Rats; D060765:Secretoglobins; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014598:Uteroglobin; D060788:Mammaglobin B
D000727:Androgen-Binding Protein; D004873:Ergolines; D004958:Estradiol; D008090:Lisuride; D007986:Luteinizing Hormone; D011388:Prolactin; D060789:Prostatein; D060765:Secretoglobins; D013739:Testosterone; D014598:Uteroglobin; C511484:Scgb1d2 protein, rat; C511483:Scgb1d4 protein, rat; C556468:Scgb2a1 protein, rat; D060788:Mammaglobin B