Current needs for new beta-lactam antibiotics in pediatrics.
Six common clinical situations in infants and children are discussed from the point of view of standard therapeutic regimens: neonatal sepsis and meningitis; febrile episodes in neutropenia; bacterial meningitis; acute pulmonary exacerbations of cystic fibrosis; pneumonia, bone and joint infections, and cellulitis in patients less than four years of age; and intra-abdominal sepsis. Potential or actual problems with these therapeutic regimens and newer therapeutic options are outlined.
D000005:Abdomen; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008581:Meningitis / Q000188:drug therapy; D009503:Neutropenia / Q000150:complications; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams