[Migration activity of peritoneal exudate cells of Syrian hamsters at different times after suppression of their natural resistance to tumors].
A study was made of migration activity (MA) of peritoneal macrophages of Syrian hamsters after depression of their antitumor natural resistance (NR) induced by injection by heat-inactivated tumor cells. The MA and depression of NR were most pronounced between day 14 and day 20 after inoculation of the animals with inactivated tumor cells of E-1 and STHE-LM8 tumor cells. Inoculation of the hamsters with heat-inactivated tumor cells of another strain (parenteral STHE) did not induce NR depression or enhanced MA of peritoneal macrophages of the treated animals. It is concluded that depression of antitumor NR essential for tumor induction and growth is apparently connected with alterations in the functional activity of macrophages, possibly with their suppressor activity.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology*; D002465:Cell Movement; D006224:Cricetinae; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology*; D008647:Mesocricetus; D009369:Neoplasms / Q000276:immunology* / Q000662:veterinary
Migratsionnaia aktivnost' kletok peritoneal'nogo ékssudata siriĭskikh khomiakov v razlichnye sroki posle podavleniia ikh estestvennoĭ rezistentnosti k opukholi.