Effects of fatty acid chain length and saturation on gastric inhibitory polypeptide release in obese hyperglycaemic (ob/ob) mice.
Plasma gastric inhibitory polypeptide (GIP) responses to equimolar intragastrically administered emulsions of fatty acids (2.62 mmol/7.5 ml/kg) were examined in 18 h fasted obese hyperglycaemic (ob/ob) mice. Propionic acid (C3:0), a saturated short-chain fatty acid, and capric acid (C10:0), a saturated medium chain fatty acid, did not significantly stimulate GIP release. However, the saturated long-chain fatty acid stearic acid (C18:0), and especially the unsaturated long-chain fatty acids oleic (C18:1), linoleic (C18:2) and linolenic (C18:3) acids produced a marked GIP response. The results show that chain length and to a lesser extent the degree of saturation are important determinants of fatty acid-stimulated GIP release. The GIP-release action of long-chain, but not short-chain, fatty acids may be related to differences in their intracellular handling.
D000818:Animals; D004655:Emulsions; D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008820:Mice, Obese / Q000378:metabolism*; D013329:Structure-Activity Relationship
D004655:Emulsions; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D005749:Gastric Inhibitory Polypeptide