Detection of a new non-MHC alloantigenic system (SLD) in pigs.
A new, non-MHC cell membrane leucocyte alloantigen was detected in pigs by the complement dependent lymphocytotoxic technique. The new leucocyte system was designated SLD. Its product antigen SLD-1 was demonstrated to segregate independently of the SLA, SLB, SLC, A and E antigens. Family studies supplied evidence of a dominant inheritance of SLD-1. Since an allelic antigen could not be demonstrated, only two alleles for this locus are reported, namely SLD1 and SLD-. No evidence of linkage was detected between the above mentioned leucocyte alloantigenic systems and SLD. The antigen was detected on enriched suspensions of T and B cells from peripheral blood, but it was not detected on erythrocytes, granulocytes and thrombocytes.
D000483:Alleles; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000302:isolation & purification; D001789:Blood Group Antigens / Q000235:genetics; D007519:Isoantigens / Q000235:genetics / Q000302:isolation & purification*; D007962:Leukocytes / Q000276:immunology; D013552:Swine / Q000097:blood / Q000235:genetics / Q000276:immunology*
D000954:Antigens, Surface; D001789:Blood Group Antigens; D007519:Isoantigens