[Effect of radiation and radioprotectors on the properties of hematopoietic stem cells].
Sublethal irradiation of donors leads to a change in some properties of bone marrow haemopoietic stem cells (HSC) during the exponential growth (days 1-8) of the syngeneic recipients in the spleen. They are: an increase in the rate of proliferation, a slight reduction in time of the population doubling, and a tendency toward an increase in the percentage of cells settled in the spleen after transplantation. These changes in the properties of HSC provide a more rapid repopulation thereof as compared to HSC of intact mice. In all appearance, a pretreatment of donors with AET and 2ADT does not influence the HSC changes induced by radiation, and, at the same time, retains the number of HSC at a high level.
D000818:Animals; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D013843:Thiazines; D000338:beta-Aminoethyl Isothiourea; C018450:2-amino-5,6-dihydro-4H-1,3-thiazine
Vliianie radiatsii i radioprotektorov na nekotorykh svoĭstva gemopoéticheskikh stvolovykh kletok.