Vinyl acetate: DNA-binding assay in vivo.
The question of carcinogenicity of vinyl acetate led us to perform a DNA binding assay in vivo in rats, using 14C-labelled vinyl acetate. After administration of [14C]vinyl acetate to male and female Fischer-344 rats, either orally or by inhalation, no specific hepatic DNA adducts, known to occur after administration of labelled vinyl halides or vinyl carbamates, could be detected in hepatic tissues.
D000818:Animals; D002250:Carbon Radioisotopes; D004247:DNA / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014753:Vinyl Compounds / Q000378:metabolism*
D002250:Carbon Radioisotopes; D014753:Vinyl Compounds; D004247:DNA; C011566:vinyl acetate