title: Synthesis and biodistribution of [18F]-5-fluorocytosine.
abstract: [18F]-5-fluorocytosine was prepared by reaction of [18F]-acetylhypofluorite with cytosine in acetic acid and was isolated in an overall radiochemical yield of 20%. Tissue distribution studies in sarcoma-bearing rats indicated in vivo stability, limited tissue uptake and rapid urinary excretion.
mesh_terms: D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives*; D005437:Flucytosine / Q000302:isolation & purification / Q000378:metabolism*; D005461:Fluorine / Q000302:isolation & purification / Q000378:metabolism*; D011868:Radioisotopes / Q000302:isolation & purification / Q000378:metabolism*; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging*; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes; D005461:Fluorine; D003596:Cytosine; D005437:Flucytosine