Reliability of lecithin/sphingomyelin ratios in diabetic pregnancy.
Diabetic pregnancy is said to be associated with a delay in pulmonary maturity and significant false-positive rates for the lecithin/sphingomyelin (L:S) ratio. Lecithin/sphingomyelin ratios without routine estimation of phosphatidylglycerol in the management of 102 insulin-dependent diabetics were analyzed to assess whether or not these ratios were mature at 37 weeks and whether or not the method used was reliable. Only two of 102 (1.9%) values were reported at less than 2 to 1 from amniocentesis at 37 weeks' gestation. The incidence of respiratory distress syndrome was zero. The authors concluded that the L:S ratio measured by the method used, is a reliable predictor of lung maturity in diabetic pregnancy and that with strict glucose homeostasis, normal pulmonary maturation occurs by 37 weeks' gestation in diabetic pregnancy.
D000653:Amniotic Fluid / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002585:Cesarean Section; D002855:Chromatography, Thin Layer; D005189:False Positive Reactions; D005260:Female; D005325:Fetal Organ Maturity; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D008168:Lung / Q000196:embryology*; D010713:Phosphatidylcholines / Q000378:metabolism*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010713:Phosphatidylcholines; D013109:Sphingomyelins