Chemical transformation of eremofortin C into PR toxin.
The natural products of both eremofortin C (EC) and PR toxin are secondary metabolites of Penicillium roqueforti. Because the chemical structures of EC and PR toxin are closely related to each other and differ only by a hydroxyl functional group in EC and an aldehyde functional group in PR toxin at the C-12 position, the chemical transformation of EC into PR toxin was investigated. Oxidation with a chromic anhydride-pyridine complex was found to be the most satisfactory method.
D009284:Naphthols; D010084:Oxidation-Reduction; D010407:Penicillium / Q000378:metabolism; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes
D009284:Naphthols; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C015188:eremofortin C; C015483:PR Toxin