Effect of pyridoxine deficiency in young rats on high-affinity serotonin and dopamine receptors.
The high-affinity bindings of [3H]-5-hydroxytryptamine to serotonin S-1 receptors, [3H]-ketanserin to serotonin S-2 receptors in the cerebral cortex, [3H]-fluphenazine to dopamine D-1 receptors, and [3H]-spiroperidol to dopamine D-2 receptors in the corpus striatum were studied in pyridoxine-deficient rats and compared to pyridoxine-supplemented controls. There was a significant increase in the maximal binding (Bmax) of serotonin S-1 and S-2 receptors with a significant decrease in their binding affinities (Kd). However, there were no significant changes either in the maximal binding or binding affinity of striatal dopamine D-1 and D-2 receptors. Receptor sensitivity seems to correlate negatively with the corresponding neurotransmitter concentrations in the pyridoxine-deficient rats.
D000818:Animals; D001835:Body Weight; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005476:Fluphenazine / Q000378:metabolism; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis*; D011985:Receptors, Serotonin / Q000032:analysis*; D012701:Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012701:Serotonin; D013134:Spiperone; D005476:Fluphenazine