[Effect of caffeine on fetal heart rate and caffeine consumption habits in pregnant patients].
Responsiveness to caffeine was studied in early human fetal hearts surviving in nutrient solution. Alterations of the spontaneous contraction rate were followed. Three concentrations (0.01, 0.1 and 1 mmol/l) were applied. In the presence of caffeine there was a significant age- and concentration-dependent increase in fetal heart rate in the period of the 6th to 17th weeks of gestation. Concerning the caffeine consumption habits of pregnant women a questionaire investigation was carried out in 686 cases. 69 per cent of the pregnants regularly drink coffee; 10.7 per cent of them consumes more than 300 mg per day. The authors call attention to the potential harmful effect of caffeine on the fetal heart.
D002110:Caffeine / Q000008:administration & dosage*; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D002110:Caffeine
Die Wirkung des Koffeins auf die fetale Herzfrequenz und die Koffeinkonsum-Gewohnheiten der Schwangeren.