Conversely exposure-related effects between atmospheric m-xylene concentrations and human body sense of balance.
Effects of fixed and fluctuating concentrations of m-xylene in air were studied on human psychophysiological functions. Nine healthy male volunteers were exposed to m-xylene 4 hrs a day, 3 hrs in the morning and 1 hr in the afternoon, with a 40 min. break in between. The subjects were sedentary or exercised at 100 W for 10 min at the beginning of each session in the chamber. The m-xylene concentrations in the air were fixed (8.2 mumol/l; 870 mg/m3) or fluctuated with peaks (5.2-16.4 mumol/l; 550-1740 mg/m3) but the TWA (8 hrs) concentration of m-xylene was always 4.1 mumol/l (435 mg/m3). The two control days, with and without exercise, were similar to the exposure days, but without exposure. Reaction times were measured with a device in which subjects responded to visual and auditory stimuli. Body sway was measured with the subjects' eyes open and closed with a strain gauge transducer platform. Changes in reaction times did not correlate with m-xylene concentrations in the air. Changes of average and maximal body sway were, however, consistently negatively correlated with the intensity of the atmospheric exposure to m-xylene at the beginning of each session in the chamber. Physical exercise combined with exposure to m-xylene improved rather than impaired body sway.
D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D014992:Xylenes / Q000097:blood / Q000633:toxicity*
D000393:Air Pollutants; D014992:Xylenes; C031285:3-xylene