title: [Pharmacokinetics of phosphocreatine in the blood serum of man, dogs and rabbits].
abstract: It is shown that a single intravenous injection of phosphocreatine to man or to experimental animals is followed by its rapid clearance from blood serum. This clearance is biphasic in nature with a half-life of 3-5 min at the first rapid stage and of 20-33 min at the next slower stage. To maintain the constant phosphocreatine concentration in blood, it is necessary to infuse it at a rate comparable to that of clearance. In particular, in blood serum of man, the phosphocreatine concentration can be kept at the level of 0.2 mM if it is injected at a rate of 60 mg/h per kg bw.
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D007700:Kinetics; D010725:Phosphocreatine / Q000097:blood*; D011817:Rabbits
chemical_list: D010725:Phosphocreatine
vernacular_title: Farmakokinetika fosfokreatina v syvorotke krovi u cheloveka, sobaki i krolika.