title: Preparation of 13N-beta-phenethylamine.
abstract: Nitrogen-13-labelled beta-phenethylamine[( 13N]PEA) was synthesized by Hofmann rearrangement of [13N]phenylpropionamide prepared from phenylpropionyl chloride and aqueous [13N]ammonia solution. The reaction proceeded rapidly with a fairly good yield. [13N]PEA was isolated using preparative thin-layer chromatography, and organ distribution in mice was studied preliminarily. After i.v. administration of [13N]PEA, high accumulation and long-term retention of the radioactivity were observed in the brain and the heart.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009590:Nitrogen Radioisotopes; D010627:Phenethylamines / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D009590:Nitrogen Radioisotopes; D010627:Phenethylamines; C029261:phenethylamine