title: Hyperoxalemia in renal failure and the role of hemoperfusion and hemodialysis in primary oxalosis.
abstract: Measurement of oxalate levels in 14 patients with chronic renal failure, treated by maintenance hemodialysis, revealed elevated plasma oxalate concentrations in all patients 1,075.7 +/- (SEM) 253 micrograms/dl. In 7 of these subjects the oxalate concentration was more than three times higher than the upper limit of normal. Furthermore, a strong positive correlation (r = 0.75) between serum creatinine and plasma oxalate concentration was found. A combination of hemodialysis and hemoperfusion procedure was carried out in a dialysis patient with primary oxalosis as a cause of renal failure. The average oxalate clearance of the hemodialyzer during seven hemodialysis/hemoperfusion procedures was 91 ml/min and that of the charcoal detoxifier was 24 ml/min. The amount of oxalate removed during 4 1/2 h of the hemodialysis/hemoperfusion procedure was 429 mg. This amount was calculated to be produced in about 87 h, with an oxalate generation rate of 4.9 mg/h.
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D010070:Oxalates / Q000097:blood*; D019815:Oxalic Acid; D006435:Renal Dialysis; D014508:Urea / Q000097:blood
chemical_list: D010070:Oxalates; D014508:Urea; D019815:Oxalic Acid; D003404:Creatinine