[Antioxidant systems of erythrocytes in rheumatism].
Patients with inactive and active rheumatic fever were examined for the intensity of lipid peroxidation of red blood cell membranes, lipid antioxidant system of tocopherol, non-lipid system of glutathione and related total activity of the pentosophosphate pathway of carbohydrate metabolism in red blood cells. It was established that activation of rheumatic process is accompanied by a increase in the content of diene conjugates in lipids of red blood cell membranes, a reduction of the tocopherol content in blood plasma, activation of glutathione reductase and glucose-6-phosphate dehydrogenase with the lowering of the total activity of the pentose cycle in red blood cells. The characteristics under study depended to a lesser degree on circulation insufficiency. The interrelationship between the shifts revealed is discussed, the mechanism by which they develop is suggested.
D000328:Adult; D001022:Aortic Valve Insufficiency / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005609:Free Radicals; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000097:blood; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000097:blood*; D010427:Pentose Phosphate Pathway; D012214:Rheumatic Heart Disease / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D005609:Free Radicals; D008054:Lipid Peroxides; D014810:Vitamin E; D005954:Glucosephosphate Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione
Antioksidantnye sistemy éritrotsitov pri revmatizme.