title: The healing process in normal canine arteries and in atherosclerotic monkey arteries after transluminal laser irradiation.
abstract: To evaluate the healing response of both normal and atherosclerotic arteries to laser radiation, 7 mongrel dogs and 4 hypercholesterolemic atherosclerotic monkeys underwent catheterization with a right Judkins catheter-optical fiber system designed to maximize arterial wall injury. Argon laser radiation was then delivered to the abdominal aorta and iliofemoral arteries. In the 11 animals, a total of 917 sites were irradiated in 33 arteries. Angiography did not reveal dissection or aneurysm formation; occlusive thrombosis was found in 2 arteries. Perforation of the arterial wall was a frequent complication. In animals killed between 1 hour and 4 days, light and electron microscopy of lased sites showed craters filled with a coagulum of blood and cellular debris with only a few adherent platelets. Healing occurred with a minimal inflammatory response and involved both fibroblasts and smooth muscle cells. Reendothelialization was seen in all animals killed between 7 and 14 days after lasing and was complete by 30 to 60 days. Within this period, no accelerated atherosclerosis was seen at lased sites in the hypercholesterolemic monkeys. It is concluded that transluminal lasing of normal arteries in dogs and in atherosclerotic arteries of monkeys is followed by healing and reendothelialization within a few weeks.
mesh_terms: D000792:Angiography; D000818:Animals; D001158:Arteries / Q000473:pathology / Q000528:radiation effects*; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D053685:Laser Therapy; D008253:Macaca mulatta; D008297:Male; D013927:Thrombosis / Q000209:etiology