[Hypotensive and diuretic effect of heparin in patients with glomerulonephritis].
The hypotensive and diuretic properties of heparin were evaluated in 95 patients with different clinical and morphological varieties of chronic glomerulonephritis (CGN). The arterial blood pressure dropped in all the patients treated with heparin. The maximal effect was attained toward the end of heparin treatment (by the 35th-50th day). In patients with hypertonic and mixed nephritis associated with renal failure, (the glomerular filtration rate under 35 ml/min), the BP lowering induced by heparin was accompanied by the deterioration of renal function. The diuretic and natriuretic effects were recorded in 81 out of the 95 patients. The maximal values of diuresis and sodium excretion were detected on the 14th-16th day of the treatment during the use of the maximal doses of heparin. It was established that heparin-induced inhibition of aldosterone synthesis plays the key role in the genesis of the diuretic, natriuretic and hypotensive action of the drug. It is concluded that diuretic and hypotensive properties of heparin can be made use of in the treatment of nephrological patients.
D000293:Adolescent; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004232:Diuretics / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects
D000959:Antihypertensive Agents; D004232:Diuretics; D000450:Aldosterone; D006493:Heparin
Gipotensivnoe i diureticheskoe deĭstvie geparina u bol'nykh glomerulonefritom.