Doxycycline in human oviduct mucosa and plasma 24-30 hours after an oral dose of 100 mg.
Oviductal and peripheral plasma concentrations 24 hours after the last dose of Doxycycline (DC) were studied in 17 patients. The concentration of DC in healthy oviduct mucosa was 1.3 micrograms/g (range 0.6-1.7) and 1.1 micrograms/ml (range 0.6-1.7) in plasma. One patient with severe chronic salpingitis in acute exacerbation showed 3.6 micrograms/g in tissue and 2.4 micrograms/ml in plasma in proliferative phase.
D000328:Adult; D000368:Aged; D004318:Doxycycline / Q000008:administration & dosage / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D012488:Salpingitis / Q000188:drug therapy; D013997:Time Factors
D004318:Doxycycline