title: [A clinical study of cefoperazone in surgery. Prevention of postoperative infections and transfer into pleural effusion].
abstract: A clinical study of cefoperazone (CPZ) in the surgery (on the prevention postoperative infections and transfer into pleural effusion) was conducted to obtain results as follows. As for the blood concentration after a 30-minute drip infusion of CPZ 2 g, it was 115.6 +/- 19.88 micrograms/ml (Mean +/- S.E.) 1 hour after completion of the administration. The biological half-life was 2.16 hours. The pleural effusion concentration of CPZ showed 33.3 +/- 7.86 micrograms/ml 2 hours after completion of the administration, which was enough to inhibit the growth of bacteria isolated from sputum and pleural effusion. The excretion was very slow. As for the effectiveness of CPZ for prevention of postoperative infection, CPZ proved effective in all of 8 cases. Specific side-effects were not observed. Thus, the usefulness of this preparation was confirmed.
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000517:prevention & control*; D002438:Cefoperazone / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000378:metabolism*; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D012140:Respiratory Tract Diseases / Q000601:surgery
chemical_list: D002438:Cefoperazone