Comparison of cytotoxicity of single dose and infusion of alkylating agents.
Both cytotoxicity and host toxicity were examined for the alkylating agents HN2, BCNU and L-PAM administered intravenously (IV) either as a single bolus injection or a 24-hour infusion. The bolus injection was more effective than the infusion schedule at a given dose for BCNU and L-PAM. Unexpectedly, the HN2 infusion schedule was more effective than bolus injection at a given dose. When host survival was the endpoint, both HN2 and L-PAM were shown to be more effective by the infusion schedule.
D000477:Alkylating Agents / Q000008:administration & dosage* / Q000633:toxicity; D000818:Animals; D002330:Carmustine / Q000008:administration & dosage / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003114:Colony-Forming Units Assay; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000633:toxicity; D051379:Mice; D008811:Mice, Inbred DBA; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000633:toxicity
D000477:Alkylating Agents; D009588:Nitrogen Mustard Compounds; D008558:Melphalan; D002330:Carmustine