Channeling of ammonia from glutaminase to carbamoyl-phosphate synthetase in liver mitochondria.
In isolated rat-liver mitochondria the rate of citrulline synthesis from glutamine does not respond to changes in the ammonia concentration in the extramitochondrial fluid. This suggest that ammonia, produced in the mitochondria via glutaminase, is directly channeled to carbamoyl-phosphate synthetase.
D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000378:metabolism*; D002956:Citrulline / Q000096:biosynthesis; D005973:Glutamine / Q000378:metabolism*; D008025:Ligases / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid
D013386:Succinates; D005973:Glutamine; D002956:Citrulline; D000641:Ammonia; D019802:Succinic Acid; D008025:Ligases; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)