title: [Synergism of the anti-angina effect of obzidan and finoptin in patients with effort stenocardia].
abstract: The effect of propranolol-finoptin combinations was examined in 27 patients with angina of effort. Repeated exercise testing showed this combination to provide an essential antianginal effect that exceeded a mere sum of individual effects of each of the two drugs taken alone in the same doses. The high anti-anginal effect of the combination is suggestive of a synergy in their antianginal action resulting in a further reduction of myocardial oxygen requirement. Side effects necessitating discontinuation of the drugs were only recorded during the early days of the treatment; therefore, patients should be adequately monitored during the first days of the regular use of this combination.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008875:Middle Aged; D005082:Physical Exertion; D011433:Propranolol / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D011433:Propranolol; D014700:Verapamil
vernacular_title: Sinergizm antianginal'nogo deĭstviia obzidana i finoptina u bol'nykh so stenokardieĭ napriazheniia.