Antipyrine metabolism during hepatic regeneration in the rat.
We investigated antipyrine clearance and urinary excretion of 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and nor-antipyrine in rats after 70% partial hepatectomy. Antipyrine clearance recovered more slowly than liver weight but after 240 h both liver weight and antipyrine clearance had reached control values. During hepatic regeneration conversion of antipyrine to the three major metabolites was reduced, conversion to 3-hydroxymethylantipyrine being reduced more than conversion to the other metabolites. Antipyrine clearance was closely correlated to liver weight (r = 0.81), indicating a close relation between the functional hepatic mass and the liver weight during hepatic regeneration.
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives / Q000378:metabolism*; D000077553:Edaravone; D005260:Female; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology; D008115:Liver Regeneration; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
C007983:4-hydroxyantipyrine; C031820:3-hydroxymethylantipyrine; D000077553:Edaravone; D000983:Antipyrine