Mioflazine, a potentially protective drug against ischaemic damage: a study in dogs.
The protective effect of intravenous mioflazine pretreatment was examined in intact dogs on cardiopulmonary bypass. The mechanical function of the left ventricle was measured by isovolumic pressure-volume relationships. Mioflazine alone had no inotropic effect. After one hour of normothermic (37 degrees C) global ischaemia of the whole heart, no control hearts, pretreated with solvent, recovered sufficiently to support the animal's circulation; this was not the case with animals pretreated with mioflazine, they all survived. After the 30-min reperfusion period, the solvent (control) pretreated hearts had a significantly lower (P = 0.05) systolic and higher (P = 0.001) diastolic pressure-volume curve than those given mioflazine.
D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output; D003327:Coronary Disease / Q000188:drug therapy*; D003971:Diastole; D004285:Dogs; D005260:Female; D008013:Lidoflazine / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D013599:Systole
D010879:Piperazines; C041518:mioflazine; D008013:Lidoflazine