Toxicology of 1,1,2-trichloroethane in the mouse.
1,1,2-Trichloroethane (TCE) was administered to male and female CD-1 mice to evaluate its effect on standard toxicological parameters. Following determination of the acute LD50 (378 mg/kg in males and 491 mg/kg in females), and a 14-day range-finding study, a 90-day drinking water study was performed in which the doses consumed were 4.4, 46, and 305 mg/kg for males and 3.9, 44, and 384 mg/kg for females. The liver was a target of TCE toxicity in both sexes as demonstrated by dose-dependent alterations in hepatic microsomal enzyme activities and serum enzyme levels. The erythroid element of the female mice was also affected, as indicated by significantly decreased hematocrit and hemoglobin levels.
D000818:Animals; D001774:Blood Chemical Analysis; D001777:Blood Coagulation / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007928:Lethal Dose 50; D007958:Leukocyte Count; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D012737:Sex Factors; D013997:Time Factors; D014240:Trichloroethanes / Q000633:toxicity*
D006843:Hydrocarbons, Chlorinated; D014240:Trichloroethanes; C024567:1,1,2-trichloroethane; D005978:Glutathione