[Glycosaminoglycans in pleural effusions. Preliminary results].
Distinction between benign and malignant pleural effusions is often a very difficult problem. Glycosaminoglycans play an important role in cellular proliferation and differentiation. The authors examined glycosaminoglycans in 17 samples, 11 malignant and 7 benign. Separation of glycosaminoglycans has been achieved by centrifugation-addition of trichloracetic acid-centrifugation-addition of cold ethanol. Glycosaminoglycans have been analyzed by electrophoresis on cellulose acetate sheets. 6 malignant samples had higher levels of HA and CS than standard. The authors distinguished benign effusions in two subgroups: inflammatory and cardiac. Among inflammatory, 3 had higher levels of HS and 1 of HA and CS. Further investigations are necessary to elucidate possible different patterns.
D000368:Aged; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis*; D006497:Heparan Sulfate / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000175:diagnosis* / Q000378:metabolism
D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D006820:Hyaluronic Acid
I glicosaminoglicani nei versamenti pleurici. Risultati preliminari.