[Myocardial involvement in nontraumatic rhabdomyolysis following an opiate overdose].
Eight young addicts developed rhabdomyolysis as a complication of heroin overdose. ECG, plasma enzyme time activity curves and thallium myocardial scintigraphy were highly suggestive of a myocardial lesion associated with rhabdomyolysis. Such changes were particularly striking in 3 patients with acute left ventricular failure, as shown by a hemodynamic investigation (3 patients) and by echocardiography (1 patient). All patients recovered but myocardial scintigraphy and ECG remained abnormal for a period ranging from 8 months to 3 years following the acute episode. Although associated metabolic changes may play a role in myocardial dysfunction, the most likely mechanism appears to be a direct toxic effect of heroin on cardiac muscle.
D000328:Adult; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000175:diagnosis; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects; D003932:Heroin / Q000009:adverse effects; D006556:Heroin Dependence / Q000150:complications*; D006801:Humans; D008297:Male; D011868:Radioisotopes; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013793:Thallium
D011868:Radioisotopes; D003932:Heroin; D013793:Thallium
Participation myocardique à la rhabdomyolyse non traumatique après surdosage aux opiacés.