Age- and sex-related differences in urinary excretion of 6 beta-hydroxycortisol in humans.
A study of normal subjects showed that the 24-h urinary 6 beta-hydroxycortisol level is age-dependent, with a maximum at 14-20 yr in both men and women. The ratio of 6 beta-hydroxycortisol/cortisol also showed an age-dependent variation, being higher in children than adults. There was a significant difference between boys and girls aged 5-10 yr, but no difference in other subjects. No sex difference was demonstrable in the ratio of 6 beta-hydroxycortisol/cortisol. Examination of circadian rhythm revealed that 6 beta-hydroxycortisol and cortisol correlated well in children, but showed poor correlation in adults, with a lowered morning peak of 6 beta-hydroxycortisol.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000652:urine; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
C001380:6 beta-hydroxycortisol; D006854:Hydrocortisone