title: Effect of low-dose dopamine on effective renal plasma flow and glomerular filtration rate in 32 patients with IgA glomerulopathy.
abstract: Low doses of dopamine are known to increase renal blood flow without influencing heart rate or systemic blood pressure. Indeed this effect was observed in 32 patients with IgA glomerulopathy. A concomitant increase in glomerular filtration rate (GFR), however, was only observed in patients with a baseline GFR greater than or equal to 73 ml/min/1.73 m2. Moreover, the change in GFR during dopamine infusion increased with increasing baseline GFR. We conclude that in IgA glomerulopathy nephron loss is compensated for by a progressive utilization of the kidney's functional reserve capacity which seems exhausted when compensated GFR falls below 73 ml/min/1.73 m2.
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D000368:Aged; D004298:Dopamine / Q000008:administration & dosage; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D005922:Glomerulonephritis, IGA / Q000503:physiopathology*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects*
chemical_list: D004298:Dopamine