[The lyophilized homologous nerve graft for the prevention of neuroma formation (animal experiment study)].
Animal experiments were performed in an attempt to prevent formation of amputation neuromas. For this purpose lyophilized homologous nerve transplants were used. Experiments were performed with the sciatic nerve of the rat. Results were compared with those achieved by using fresh autologous transplants and by covering the nerve ends with fibrin glue. Axons exhibited reduced growth within the empty spaces of the lyophilized transplant thus limiting uncontrolled growth of axons. Neuromas never occurred at the free end of this lyophilized transplant. Neuromas observed (13 out of 90) occurred at the juncture site. With respect to suture techniques epineural suture in combination with fibrin glue proved to be best.
D000671:Amputation, Surgical / Q000009:adverse effects*; D000818:Animals; D005337:Fibrin; D005552:Forelimb / Q000601:surgery; D005612:Freeze Drying; D009463:Neuroma / Q000517:prevention & control*; D051381:Rats; D012584:Sciatic Nerve / Q000637:transplantation* / Q000648:ultrastructure; D014014:Tissue Adhesives; D014184:Transplantation, Homologous
D014014:Tissue Adhesives; D005337:Fibrin
Das lyophilisierte homologe Nerventransplantat zur Verhinderung der Neurombildung (tierexperimentelle Studie).