The effect of diflunisal administration on platelet aggregation and cerebral blood flow.
The effect of a high dose of diflunisal (750 mg twice daily) on platelet aggregation and cerebral blood flow was investigated in 8 healthy volunteers. Diflunisal inhibited platelet aggregation consistently; this effect on platelets was reversed within 24 hours after the last dose of diflunisal. There was, however, no correlation between the anti-aggregatory effect of diflunisal and its plasma concentration. Diflunisal did not alter cerebral blood flow.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004061:Diflunisal / Q000097:blood / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D012459:Salicylates / Q000494:pharmacology*; D013997:Time Factors
D012459:Salicylates; D000244:Adenosine Diphosphate; D004061:Diflunisal; D004837:Epinephrine