title: Evaluation of immunity of sheep after splenectomy, splenic artery ligation and autotransplantation of splenic tissue.
abstract: The studies aiming at evaluation of immunity after splenectomy, splenic artery ligation, and autotransplantation of splenic tissue were performed in sheep. It was found that splenectomy alters both humoral and cellular immunity. The phagocytic activity of granulocytes, reduced level of IgG, drop in T and ARF cells as well as bone marrow stimulation were noted. In animals subjected to splenic artery ligation or autotransplantation of splenic tissue no significant differences in parameters studied were observed. These results correlated with histological examinations indicate that in the case of spleen trauma two important steps should be followed: the spleen, if possible, should be saved or a spleen saving procedure should be employed; in case of extensive trauma or if contraindications for spleen saving exist, autotransplantation of splenic tissue should be performed.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D007111:Immunity, Cellular; D008026:Ligation; D010587:Phagocytosis; D010976:Platelet Count; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology* / Q000293:injuries / Q000637:transplantation; D013156:Splenectomy; D013157:Splenic Artery / Q000601:surgery; D013211:Staphylococcus aureus / Q000276:immunology
chemical_list: D001323:Autoantibodies