Modulation of the host-versus-graft reaction of the popliteal lymph node by small numbers of dendritic cells injected at a distant site.
This paper demonstrates that dendritic cells (DC) injected intraperitoneally into CBA mice can alter the popliteal lymph node response of the animals to semi-allogeneic spleen cells injected into the footpad. This effect is antigen specific, for both cell populations must share the same foreign antigenic determinants. The alteration is expressed as an augmentation of node swelling following injection of very low numbers of DC, whilst a slight increase in the numbers of DC leads to suppression of the host-versus-graft response. Therefore it would appear that, in addition to their role as antigen-presenting cells, DC are also capable of modulating the response to an allogeneic stimulus in an antigen-specific manner. It is postulated that such antigen-specific modulation arises from formation of complexes between prostaglandin E1 and antigen-presenting moieties, which then determine the direction of the immune response.
D000818:Animals; D002469:Cell Separation; D005260:Female; D006789:Host vs Graft Reaction; D007116:Immunization, Passive; D007274:Injections, Intraperitoneal; D007717:Knee; D008198:Lymph Nodes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000166:cytology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology