title: A prospective trial of the fetal biophysical profile versus the nonstress test in the management of high-risk pregnancies.
abstract: A randomized prospective trial study was developed to determine the diagnostic value of the fetal biophysical profile in relationship to the nonstress test. The diagnostic values of these tests were assessed in terms of the incidence of abnormal outcome. In addition comparisons between the positive and negative predictive values of each of these tests as well as the sensitivity and specificities of the test were reviewed. A total of 652 patients were entered into the study and a total of 1628 tests were performed. Of the group 279 pregnancies were managed by a biophysical profile protocol and 373 by the nonstress test protocol. Results of this study suggest that except for the negative predictive value in the sensitivities in the outcome parameters of low 5-minute Apgar scores the diagnostic values for all outcome parameters were consistently higher in the fetal biophysical profile as opposed to the nonstress test group. While higher, only two of the values, positive predictive value of overall abnormal outcome and negative predictive value of small for gestational age infants, were statistically significant. While this general trend suggests that the biophysical profile is more predictive in diagnosing fetal condition than the nonstress test, because statistical significance was not reached in all parameters further study is warranted.
mesh_terms: D000653:Amniotic Fluid / Q000502:physiology; D001034:Apgar Score; D036861:Delivery, Obstetric; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005318:Fetal Heart / Q000502:physiology; D005323:Fetal Monitoring / Q000379:methods*; D005324:Fetal Movement; D005333:Fetus / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D011446:Prospective Studies; D011897:Random Allocation; D012119:Respiration; D012306:Risk