An examination of the arterial media in transplanted arteries of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY).
The hypothesis that arterial medial hypertrophy occurs in the SHR due to genetic factors inherent to the arterial wall, was examined in jejunal arteries cross transplanted between four-week-old SHR and WKY rats as a shunt between the femoral artery and vein. Four weeks after transplant, the arteries were removed and processed for embedding in resin and measurement of wall parameters by light microscopy. It was determined that irrespective of the origin of the transplanted artery, the wall thickness of transplants was higher in SHR hosts than in WKY hosts. Taken with results from other studies, this suggests that genetic factors inherent to the arterial wall are not the cause of arterial hypertrophy in the SHR.
D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000473:pathology*; D006984:Hypertrophy; D008638:Mesenteric Arteries / Q000473:pathology / Q000637:transplantation; D009131:Muscle, Smooth, Vascular / Q000473:pathology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY