title: Increased concentrations of milk antibodies in recurrent pulmonary aspiration in infants and young children.
abstract: Concentrations of circulating antibodies against bovine serum albumin were significantly increased in six children with recurrent pulmonary aspiration (mean: 5.54 micrograms BSA-N/ml, range: 2.05-12.87 micrograms BSA-N/ml; mean value of 76 control infants: 0.38 microgram BSA-N/ml, 95% confidence interval: 0-0.98 microgram BSA-N/ml, p less than 0.001) as determined by radioimmuno-assay. IgG- and IgA-isotypes against bovine serum albumin, lactalbumin, lactoglobulin, casein and gammaglobulin were determined in four patients by enzyme-linked-immuno-sorbent-assay. Significant differences between patients and controls were found for IgG-antibodies against casein and bovine serum albumin and IgA-antibodies against alpha-lactalbumin and bovine serum albumin. Under certain conditions, stimulation of bronchus-associated lymphoid tissue may lead to a higher immune response than oral immunization. Determination of milk antibodies may be helpful in the diagnosis of recurrent pulmonary aspiration.
mesh_terms: D000906:Antibodies / Q000032:analysis*; D001903:Bottle Feeding; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D008894:Milk Proteins / Q000276:immunology*; D011015:Pneumonia, Aspiration / Q000276:immunology*; D012008:Recurrence; D012710:Serum Albumin, Bovine / Q000276:immunology
chemical_list: D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008894:Milk Proteins; D012710:Serum Albumin, Bovine