[Androgen receptors in the pubic skin and testosterone content of the blood in women with hirsutism].
A study was made of "free" binding sites and the total number of sites binding androgens with the cytoplasmic receptor protein in the pubic skin biopsy specimens and testosterone in the blood serum of patients with hirsutism, degree II-III. A higher mean level of testosterone was found in the blood serum of patients with hirsutism, degree II-III, suffering from hyperandrogenism of ovarian and/or adrenal origin as compared to women with idiopathic hirsutism, degree I-III. "Free" sites of the binding of 5 alpha-dihydrotestosterone (DHT) with receptors were not revealed in most of the patients, however the total number of sites of the binding of DHT with cytoplasmic receptors were found in all the studied skin biopsy specimens. The results obtained show that there are significant differences in the testosterone level in the blood serum and the total number of DHT binding sites in the pubic skin cytosol of women with idiopathic hirsutism and patients with hirsutism, degree II-III, with hyperandrogenism of ovarian and/or adrenal origin.
D000293:Adolescent; D000328:Adult; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000378:metabolism*; D006801:Humans; D011944:Receptors, Androgen / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D011944:Receptors, Androgen; D013739:Testosterone
Retseptory androgenov v kozhe lobka i soderzhanie testosterona v krovi zhenshchin s girsutizmom.