Ozone-induced inhibition of theophylline elimination in rabbits: effect of age and sex.
The effect of age and sex on the elimination of theophylline in New Zealand White rabbits was investigated following exposure to 0.3 ppm of ozone (O3) for 3.75 hr/day over 5 consecutive days. Animals were given air alone 5 to 7 days before and after the 5 days of O3 exposure. The elimination half-life of theophylline was significantly (p = 0.004) prolonged on Days 1 and 5 of O3 exposure in the rabbits greater than 2 years old, with no effect being seen in those 3 to 4 months old. No O3-induced change was seen in the apparent volume of distribution to account for the observed change in theophylline elimination half-life. The female rabbit in particular demonstrated this age-related effect; while in the male, variability prevented the observed difference from reaching significance. The results indicated inhibition of theophylline elimination by O3 in the rabbit depends on age and sex.
D000375:Aging; D000818:Animals; D005260:Female; D006207:Half-Life; D008297:Male; D010126:Ozone / Q000633:toxicity*; D011817:Rabbits; D012737:Sex Factors; D013806:Theophylline / Q000378:metabolism*
D010126:Ozone; D013806:Theophylline