[Comparison of morphological and biochemical indicators of prostatic growth and function in castrated rats receiving separately and simultaneously 5 alpha-dihydrotestosterone and 5 alpha-androstane-3 beta, 17 beta-diol].
Experiments in vito showed that indicators of prostatic growth (organ mass, protein content, DNA) and function (acid phosphatase activity) of castrated rats regenerated under the influence of 5 alpha-dihydrotestosterone. The morphological structure of this organ showed a pronounced activation of the glandular epithelium proliferation by this metabolite without a significant effect on the connective tissue. The other testosterone metabolite 5 alpha-androstan-3 beta, 17 beta-diol did not influence biochemical indicators but according to the morphological data it stimulated the secretory activity of the glandular epithelium and connective tissue formation. As a result of a combined effect of the metabolites the influence of 5 alpha-dihydrotestosterone on the proliferative processes in the prostate was limited, and the response of the connective tissue to 5 alpha-androstan-3 beta, 17 beta-diol preserved. The results obtained were not in accord with a hypothesis that 5 alpha-dihydrotestosterone is the only physiologically active testosterone metabolite in the rat pancreas, and confirmed the idea of androgen functional interrelationship.
D000135:Acid Phosphatase / Q000378:metabolism; D015113:Androstane-3,17-diol / Q000008:administration & dosage*; D000732:Androstanols / Q000008:administration & dosage*; D000818:Animals; D004247:DNA / Q000378:metabolism; D013196:Dihydrotestosterone / Q000008:administration & dosage*; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000254:growth & development / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000732:Androstanols; D011506:Proteins; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D004247:DNA; D000135:Acid Phosphatase
Sopostavlenie morfologicheskikh i nekotorykh biokhimicheskikh pokazateleĭ rosta i funktsii predstatel'noĭ zhelezy kastrirovannykh krys, poluchayshikh razdel'no i odnovremenno 5 alpha-digidrotestosteron i 5 alpha-androstan-3 beta, 17 beta-diol.