Effects of ethylenediamine on morphine analgesia and tolerance-dependence in mice.
Ethylenediamine, a GABA receptor agonist induced a small hyperalgesic state in mice, but increased morphine analgesia. The interaction with this morphine effect was not dose-dependent. Ethylenediamine significantly antagonized tolerance development at relatively low doses (5-10 mg/kg). The GABA mimetic agent increased the frequency of abstinence signs in the naloxone-precipitated morphine withdrawal in mice. The effect of ethylenediamine on morphine withdrawal was suppressed by the irreversible GABA transaminase inhibitor, gamma-vinyl GABA.
D000698:Analgesia; D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D005029:Ethylenediamines / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence; D009270:Naloxone / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced
D005029:Ethylenediamines; D009270:Naloxone; C031234:ethylenediamine; D009020:Morphine