Aminoglycoside peritoneal lavage: lack of efficacy in experimental fecal peritonitis.
The utility of an adjunctive aminoglycoside lavage in the prevention of intra-abdominal abscesses utilizing an experimental rodent model was studied. Peritonitis was created in 115 rats by the intra-abdominal placement of gelatin capsules containing a barium-sulfate, human stool mixture. Four hours later, the animals were re-explored and lavaged with 30 ml/kg of sterile saline. Following the lavage, they were randomized to receive 15 ml/kg of either a 0.2% gentamicin or a normal saline lavage. The animals were then treated with intramuscular gentamicin-clindamycin or saline placebo for nine days. There was no difference in the number of abscesses between the groups receiving systemic antibiotics. The addition of gentamicin to a peritoneal lavage did not decrease the incidence of intra-abdominal infection in animals receiving effective systemic antibiotics.
D000005:Abdomen; D000038:Abscess / Q000209:etiology / Q000517:prevention & control*; D000617:Aminoglycosides / Q000627:therapeutic use*; D000818:Animals; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D005243:Feces; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010538:Peritonitis / Q000150:complications*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D007507:Therapeutic Irrigation
D000617:Aminoglycosides; D004338:Drug Combinations; D005839:Gentamicins; D002981:Clindamycin