title: Quantitative 123I-iodide scintigraphy and radiation dosimetry in infants with congenital hypothyroidism.
abstract: Quantitative studies of 123I-iodide uptake using a gamma camera were undertaken in 23 infants with congenital hypothyroidism. Background oral radioactivity was reduced by ensuring that the infants drank fruit juice during the study. In 7 cases, there was no evidence of functioning thyroid tissue, in 13 cases, lingual tissue was present, and in 3 cases, there was uptake at the normal thyroid site. Dyshormonogenesis, as shown by a positive perchlorate discharge at 30-60 min after radioiodine administration, was present in 5 of the cases with demonstrable uptake. The estimated 20-min uptake of 123I-iodide was less than 2.6% of the dose in all cases except 1; in this case, the uptake was 10.4%, but this was completely discharged by perchlorate. There was good agreement between the quantitative radioiodine-uptake and -discharge results and the circulating thyroid-hormone levels. The estimated radiation dose to thyroid tissue using the technique was 9.2 mSv for an intravenous administration of 2MBq 123I-iodide.
mesh_terms: D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000000981:diagnostic imaging; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes; D008297:Male; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013974:Thyroxine