title: Effects of X-ray irradiation on hearing in guinea pigs.
abstract: Effects of X-ray irradiation on the hearing with CM and ABR to both air- and bone-conduction stimuli were studied continuously from immediately after the irradiation to a few weeks later. At 2, 4, and 6 krad, only slight conductive hearing impairment was found, but at 8 krad or more, CM and ABR disappeared abruptly, after having increased briefly. Advanced sensorineural hearing loss appeared at about 10 hours after irradiation ended at 8 krad, at about 6 hours at 10 krad, and at about 3 hours at 12 krad. More severe hearing impairment was observed at higher frequencies and the endocochlear d.c. potential (EP) decreased at about 7 hours after 10 krad irradiation. Histologically, no discernible changes in the hair cells or sensory hairs were found with a scanning electron microscope at about 6 hours after 10 krad irradiation, while with a transmission electron microscope, the outer hair cells in the basal coil of the cochlea were found to be mostly destroyed. However, no changes could be found in the inner hair cells or other supporting cells.
mesh_terms: D000818:Animals; D001844:Bone Conduction / Q000528:radiation effects; D001933:Brain Stem / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000528:radiation effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000528:radiation effects / Q000648:ultrastructure; D006309:Hearing / Q000528:radiation effects*; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011829:Radiation Dosage; D013997:Time Factors; D014965:X-Rays