[Effect of glutathione on choleragenic diarrhea and disorders of the antioxidant system of rat intestinal and liver cells].
The effects of reduced glutathione on the development of choleragenic diarrhea and the activity of glutathione transferase (GT), glutathione peroxidase (GP-GTB and GP-H2O2), superoxide dismutase (SOD), glutathione reductase (GR) in the small intestine and liver of rats with experimentally ligated jejunal loop have been studied. Diarrhea syndrome was found to decrease markedly after glutathione administration in a dose of 1 g/kg bw. GR activity in the jejunum and liver of rats treated with toxin and the following glutathione administration rose by 210 and 186%, respectively, and then reached the control level. Glutathione transferase activity in the jejunum increased by 150% (P less than 0.05), remaining, however, lower than the control values. The activity of other enzymes tested was unchanged. Polyfunctional cellular activity of glutathione suggests that antidiarrhea effect should be considered as an element of pathogenetic therapy.
D000818:Animals; D002771:Cholera / Q000517:prevention & control*; D002772:Cholera Toxin / Q000037:antagonists & inhibitors; D005978:Glutathione / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007583:Jejunum / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D002772:Cholera Toxin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione
Vliianie glutationa na kholerogennuiu diareiu i narusheniia antioksiditel'noĭ sistemy kletok kishechnika i pecheni krys.