Catecholamine sensitivity with respect to metabolic rate in man.
Most of the different thermogenic defects proposed as contributing factors in the development and maintenance of human obesity are controversial or difficult to reproduce. Since catecholamine stimulation results in an increased thermogenesis we thought that a carefully standardized dose-response test could be of value when comparing the thermogenic potential of different subjects. This report is a short summary of experiments performed in cooperation with the group of E. Jéquier in Lausanne. More detailed information is given in Sjöström et al. Am. J. Physiol. 1983, 245, E431-E442. The present report also analyses our results in relation to those in the literature.
D000328:Adult; D001481:Basal Metabolism / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D009765:Obesity / Q000503:physiopathology; D012119:Respiration / Q000187:drug effects
D009638:Norepinephrine; D004837:Epinephrine