title: High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers.
abstract: In plasma and urine of 10 healthy volunteers after intravenous administration of 4 g mezlocillin and piperacillin, respectively, the parent compounds as well as degradation products were assayed by high-performance liquid chromatography. Ioxitalamic acid, a renal contrast medium, was administered simultaneously, in order to measure the glomerular filtration rate, and to control the collection of 24-h urine. As metabolite of mezlocillin the corresponding penicilloic acid only was found, whereas in the case of piperacillin a further degradation product was observed. Half of the doses given was recovered in the urine as unchanged drugs, and in addition 5-10% as metabolites. No differences were found in the pharmacokinetic behaviour of both antibiotics.
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000652:urine; D007700:Kinetics; D008297:Male; D008802:Mezlocillin / Q000032:analysis* / Q000097:blood / Q000652:urine; D010878:Piperacillin / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D007483:Iothalamic Acid; C002587:ioxitalamic acid; D008802:Mezlocillin; D010878:Piperacillin