Effect of sex and age on serum aldosterone and thyroid hormones in the laboratory rat.
Serum levels of aldosterone, tri-iodo thyronine (T3) and thyroxine (T4) were measured in male and female rats aged 3 months, 12 months, and 18 months. Female rats were found to have higher aldosterone and T3 levels, and lower T4 level than the male. No age-related change was observed in serum aldosterone in either sex. In contrast, serum T4 were found to decrease with age in both sexes while serum T3 showed an age-associated diminution in the male only. Serum testosterone was also measured in the male rats and was found to decline with age.
D000375:Aging; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D000450:Aldosterone; D013974:Thyroxine