Vasopressin and vasotocin facilitate reversal of a brightness discrimination.
Male albino rats received vasopressin, vasotocin, pressinoic acid or placebo and were tested on an aversively motivated brightness discrimination task. Treatment with both vasopressin and vasotocin had no effect on acquisition but facilitated the reversal of the discrimination. Pressinoic acid had an inconsistent effect. The results are interpreted to show that the C terminal of the peptides vasopressin and vasotocin influence potency of these peptides. Furthermore, the results are interpreted as showing that both vasotocin and vasopressin influence selective attention during aversively motivated tasks.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001288:Attention / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D008297:Male; D051381:Rats; D012193:Reversal Learning / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014667:Vasopressins / Q000494:pharmacology; D014668:Vasotocin / Q000494:pharmacology*; D014796:Visual Perception / Q000187:drug effects
D014667:Vasopressins; D001127:Arginine Vasopressin; C009038:pressinoic acid; D014668:Vasotocin