Pharmacokinetic interaction of disulfiram and antidepressants.
Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.
D000328:Adult; D000437:Alcoholism / Q000378:metabolism / Q000517:prevention & control; D003891:Desipramine / Q000378:metabolism* / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D006900:Hydroxylation; D007099:Imipramine / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008875:Middle Aged
D007099:Imipramine; D003891:Desipramine; D004221:Disulfiram