The relationship of enzyme activity to feeding behavior in rats: lipoprotein lipase as the metabolic gatekeeper.
A model for peripheral modulation of feeding behavior is discussed. This model proposes that under certain genetic, hormonal or dietary conditions adipose tissue lipoprotein lipase (AT-LPL) acts as a gatekeeper directing triglyceride derived fuels to adipose tissue and away from other tissues. It is proposed that shifts in the activity of the gatekeeper enzyme LPL result in changed feeding behaviors in rodents and possibly in man. In the fafa rat, the alterations in LPL activity may play the role of a developmental trigger or initiator. In other cases, the changes in AT-LPL may be adaptive rather than initiatory and may be permissive of behaviors rather than necessary antecedents.
D000818:Animals; D001823:Body Composition; D005247:Feeding Behavior / Q000502:physiology*; D006801:Humans; D008071:Lipoprotein Lipase / Q000502:physiology*; D008954:Models, Biological; D009765:Obesity / Q000235:genetics / Q000503:physiopathology; D051381:Rats; D011924:Rats, Zucker; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D008071:Lipoprotein Lipase