Quantitative cytophotometric analyses of mesenteric mast cell granulation in acute soman intoxicated rats.
Effects of the organophosphate neurotoxin soman on rat mesenteric mast cell granule content were determined using scanning-integrating microdensitometric analysis of individual cell metachromasia. Mast cell degranulation was evidenced both with sublethal (0.5 LD50) and lethal (1.5 LD50) dosages and as early as 3-10 min post-injection. These data indicate a possible contribution of mast cell autacoids in the genesis of organophosphate-induced respiratory and circulatory collapse.
D000818:Animals; D002802:Cholinesterases / Q000097:blood; D003594:Cytoplasmic Granules / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism; D007928:Lethal Dose 50; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure*; D008643:Mesentery / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D012999:Soman / Q000633:toxicity*
D006493:Heparin; D012999:Soman; D002802:Cholinesterases