[Anuria, cholestatic jaundice, thrombocytopenia, hemolysis. Immunoallergic complication due to ajmaline].
A 75 year old man, treated with ajmaline, was admitted with malaise, fever, acute renal failure and cholestatic jaundice. Haemolytic anaemia and thrombocytopaenia were also found with a positive indirect Coomb's test in the presence of ajmaline. The immunological and haematological data are discussed in the light of previously published cases.
D000368:Aged; D000404:Ajmaline / Q000009:adverse effects*; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D001002:Anuria / Q000139:chemically induced* / Q000276:immunology; D002779:Cholestasis / Q000139:chemically induced* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D000404:Ajmaline
Anurie, ictère cholestatique, thrombopénie, hémolyse. Accident immunoallergique dû à l'ajmaline.