Effect of concanavalin A on the early events of rabies virus infection of CER cells.
The effect of concanavalin A on rabies virus infection of CER cells was investigated. Pretreatment of CER cells with concanavalin A inhibited cellular susceptibility to rabies virus infection. The lectin also was found to be inhibitory when applied after the viral binding step. Moreover, the lectin had a direct inhibitory effect on the infectivity of the virion. These lectin-mediated inhibitions could be reversed by alpha-D-methyl-mannopyranoside. These complex effects are discussed with regard to the mechanism of rabies virus entry into CER cells.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003208:Concanavalin A / Q000494:pharmacology*; D008766:Methylmannosides / Q000494:pharmacology; D011818:Rabies / Q000209:etiology / Q000517:prevention & control*; D011820:Rabies virus / Q000187:drug effects; D013997:Time Factors
D008766:Methylmannosides; D003208:Concanavalin A; C008466:methylmannoside