Haemorrhage and adrenocortical activity in the fowl (Gallus domesticus).
Plasma aldosterone concentrations were markedly elevated in chickens by the removal of 10-30% of their total blood volume. This aldosterone response to haemorrhage was delayed and of reduced magnitude in birds pretreated for 48 hr with dexamethasone (100 micrograms/kg every 12 hr), in which the basal aldosterone level was also suppressed. Corticosterone concentrations were elevated in both haemorrhaged and nonhaemorrhaged birds, although these responses were completely abolished by dexamethasone pretreatment, which also reduced the basal corticosterone concentration. Prolactin concentrations were unaffected by haemorrhage. These results demonstrate that haemorrhage specifically affects adrenocortical function by increasing aldosterone release and suggests that factors other than the pituitary-adrenal axis are responsible for this stimulation of secretion.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D000818:Animals; D002645:Chickens; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D006400:Hematocrit; D006470:Hemorrhage / Q000503:physiopathology*; D008297:Male
D000450:Aldosterone; D003907:Dexamethasone; D003345:Corticosterone