Acetate formation after short-term ethanol administration in man.
The effect of an acute oral load of 0.5 g ethanol/kg body weight was studied in a group of 10 healthy male and one of 10 healthy female individuals. The following parameters were measured in the blood between 0 and 7 h after the start of the experiment: ethanol, acetate, glucose, free fatty acids, free glycerol, lactate, pyruvate, 3-hydroxybutyrate, acetoacetate. While the elimination of ethanol followed zero-order kinetics between 2 and 5 h, a steady-state concentration of 0.4 to 0.6 mM acetate in the serum was observed during the same time interval. Concomitantly, a significant decrease of free fatty acid and free glycerol concentrations was observed.
D000079:Acetaldehyde / Q000378:metabolism; D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000328:Adult; D002648:Child; D000431:Ethanol / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D012737:Sex Factors
D000085:Acetates; D005230:Fatty Acids, Nonesterified; D000431:Ethanol; D000079:Acetaldehyde; D005990:Glycerol; D019342:Acetic Acid