Antisera raised against the drug haloperidol.
Antisera against haloperidol coupled to albumin have been raised in two rabbits. Both antisera bind haloperidol with high affinity but differ in their selectivity for binding other substances. A sub-population of anti-haloperidol antibodies has been partially purified from one antiserum by affinity chromatography. This sub-population resembles the D2 dopamine receptor in its ability to bind some D2 receptor selective antagonists.
D000818:Animals; D000906:Antibodies / Q000302:isolation & purification; D005260:Female; D006220:Haloperidol / Q000276:immunology* / Q000378:metabolism; D007106:Immune Sera / Q000276:immunology*; D007114:Immunization; D011817:Rabbits; D011954:Receptors, Dopamine / Q000378:metabolism
D000906:Antibodies; D007106:Immune Sera; D011954:Receptors, Dopamine; D006220:Haloperidol