Effect of danazol on the biochemical abnormality of inherited antithrombin III deficiency.
Seven members of a family affected by hereditary antithrombin III deficiency were identified. The disorder was associated with recurrent spontaneous episodes of phlebitis, deep venous thrombosis, and pulmonary embolism in middle age. Danazol, a 17-alkyl derivative of ethinyl testosterone, which has been used to treat other antiprotease deficiency states, was assessed in the management of two men with antithrombin deficiency. In a dose of 600 mg a day danazol appeared to correct the antithrombin deficiency. This drug may provide a useful adjunct to anticoagulant treatment, particularly before surgery.
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D020152:Antithrombin III Deficiency; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010689:Phlebitis / Q000188:drug therapy; D011245:Pregnadienes / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000188:drug therapy; D013927:Thrombosis / Q000235:genetics
D011245:Pregnadienes; D000990:Antithrombin III; D003613:Danazol