The effects of cardiac pacing on central hemodynamics in experimental propoxyphene-induced cardiac failure.
Coronary sinus pacing was evaluated in 10 pigs during propoxyphene-induced cardiac failure. From baseline, propoxyphene chloride 15 mg . min-1 was infused until circulatory shock developed. Cardiac pacing was evaluated at different dose levels expressed as % of the shock dose of propoxyphene: at intoxication levels below 50% of the shock dose, cardiac pacing improved cardiac performance. At dose levels above 50% of the shock dose cardiac performance deteriorated further during pacing. The results are consistent with a severe negative inotropic effect of propoxyphene in overdose.
D000818:Animals; D002304:Cardiac Pacing, Artificial; D011431:Dextropropoxyphene / Q000506:poisoning*; D006331:Heart Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D013552:Swine
D011431:Dextropropoxyphene