title: Changes in duodenal mucosal blood flow and mucus glycoprotein content during cysteamine-induced duodenal ulceration in rats.
abstract: The effects of cysteamine on duodenal mucosal blood flow and duodenal glycoprotein were studied during the development of duodenal ulceration in conscious rats. Cysteamine at an ulcerogenic dose (300 mg/kg s.c.) produced a remarkable decrease of duodenal mucosal blood flow which preceded the appearance of duodenal ulcers. The reduced blood flow was followed by a significant decrease of tissue levels of glycoprotein which also occurred prior to the time when duodenal injury had reached a maximum. Cysteamine was without significant effect on the rate of incorporation of 3H-glucosamine into duodenal glycoprotein at concentrations up to 10(-3) M. These results suggest that the reduction in duodenal mucosal blood flow in response to cysteamine could possibly contribute to a decrease of duodenal glycoprotein and that both may be at least in part responsible for the incidence of duodeno-ulcerogenecity.
mesh_terms: D000818:Animals; D003543:Cysteamine / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000503:physiopathology*; D004386:Duodenum / Q000098:blood supply; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000098:blood supply*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
chemical_list: D006023:Glycoproteins; D003543:Cysteamine