Translocation mosaicism in a woman having multiple miscarriages.
We concluded cytogenetic studies on a couple who had had several spontaneous abortions. The peripheral lymphocytes of the woman repeatedly showed a mosaic pattern with a structurally altered, apparently balanced, autosomal translocation between chromosomes 4 and 5. Various studies were reviewed and it was concluded that the true frequency of structural rearranged mosaics in recurrent pregnancy loss is not known.
D000026:Abortion, Habitual / Q000235:genetics*; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D009030:Mosaicism; D011247:Pregnancy; D014178:Translocation, Genetic