Cold reacting antibodies recognizing antigens dependent on N-acetylneuraminic acid.
Serum from a 75-year-old man with lymphoproliferative disease was found to contain a persistent cold agglutinin meeting most of the characteristics of examples of anti-Gd reported previously. It differed, however, in that it contained IgG and IgM components and its reactivity was not inhibited by sialyllactose. A search of random serums containing cold agglutinins was undertaken to determine the incidence of antibodies to antigens dependent on N-acetylneuraminic acid. Two further examples were found in 47 serums containing cold agglutinins. One of these also demonstrated a Gd or "Gd-like" specificity. The other appeared to be an anti-Pr.
D000327:Adsorption; D000328:Adult; D000368:Aged; D000373:Agglutinins / Q000032:analysis / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching / Q000379:methods; D003450:Cryoglobulins; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D008297:Male; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids; D012965:Sodium Chloride
D000373:Agglutinins; D001789:Blood Group Antigens; D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012794:Sialic Acids; C029443:cold agglutinins; D012965:Sodium Chloride; D019158:N-Acetylneuraminic Acid