[Platelet adenosine desaminase in various hematological diseases].
Activity of adenosine deaminase (EC 3.5.4.4) was studied in thrombocytes of donors and patients with various hematological diseases. The enzymatic activity was decreased in acute leukemia, chronic myeloleukemia, chronic leukemia and blast transformation myeloma, microspherocytic and hypoplastic anemias. Variable level of the activity was observed in chronic lympholeukemia and non-Hodgkin disease. In all the diseases studied functions of thrombocytes were altered after treatment with various aggregating agents (ADP, thrombin, collagen, adrenaline, ristomycin).
D000243:Adenosine Deaminase / Q000097:blood*; D000740:Anemia / Q000097:blood / Q000201:enzymology; D001792:Blood Platelets / Q000201:enzymology*; D006402:Hematologic Diseases / Q000097:blood / Q000201:enzymology*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000201:enzymology; D009196:Myeloproliferative Disorders / Q000097:blood / Q000201:enzymology; D009700:Nucleoside Deaminases / Q000097:blood*; D010974:Platelet Aggregation
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
Adenozindezaminaza trombotsitov krovi pri razlichnykh gematologicheskikh zabolevaniiakh.