An immunohistological study of giant-cell tumour of bone: evidence for an osteoclast origin of the giant cells.
Using a panel of monoclonal antibodies against a variety of lymphoid and non-lymphoid antigens the immunohistological staining pattern of giant cells from a case of giant-cell tumour of bone has been compared with that of osteoclasts from the developing ends of fetal long bones. Only EBM-11, an antibody reacting with a wide spectrum of macrophages, stained both osteoclasts and giant cells; stromal cells and osteoblasts did not react. This indicates that osteoclasts and giant cells are phenotypically and presumably functionally similar. It is argued that the osteoclasts and the tumour-derived giant cells in bone are derived from a similar mononuclear precursor.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001859:Bone Neoplasms / Q000276:immunology / Q000473:pathology*; D002454:Cell Differentiation; D005260:Female; D005333:Fetus; D005870:Giant Cell Tumors / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D010010:Osteoclasts / Q000473:pathology*
D000911:Antibodies, Monoclonal