Binding, ingestion, and multiplication of Chlamydia trachomatis (L2 serovar) in human leukocyte cell lines.
We examined the ability of lymphoblastoid-myeloid cell lines to bind, ingest, and permit multiplication of Chlamydia trachomatis (L2 serovar). Four types of chlamydia-cell line interactions were observed: minimal bacterial binding; bacterial binding, followed by ingestion and high-level multiplication; bacterial binding, followed by ingestion but minimal multiplication; and bacterial binding, but minimal ingestion or replication. Our data demonstrate that at 37 degrees C in vitro the L2 serovar can both bind avidly to a cell without entering it and enter nonphagocytic cells but not grow.
D002460:Cell Line; D002692:Chlamydia trachomatis / Q000254:growth & development* / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000382:microbiology*; D008219:Lymphogranuloma Venereum / Q000382:microbiology