[Redistribution and activation of peritoneal macrophages with the peroral use of sodium nucleinate].
Three hours after the administration of sodium nucleinate the activation of glycolysis, the hexosomonophosphate shunt, the urea cycle (determined by the analysis of key enzymes), the expression of FC gamma-receptors and the decrease of oxidizing phosphorylation were noted in the peritoneal macrophages of mice. By 36 hours the gradual decrease of these characteristics occurred. After three oral administrations of the preparation immature macrophages with lower metabolic activity and increased oxidizing phosphorylation appeared in the exudate, while resident and activated cells practically disappeared. The immaturity of the cells was confirmed by their incubation in vitro. The changes in the cells, revealed in this investigation, are supposed to occur due to the redistribution of activated and intact macrophage populations in situ.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000473:pathology; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009696:Nucleic Acids / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011961:Receptors, Fc / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D009696:Nucleic Acids; D011961:Receptors, Fc; C013683:sodium nucleinate
Pereraspredelenie i aktivatsiia peritoneal'nykh makrofagov pri peroral'nom primenenii nukleinata natriia.