Indomethacin inhibition of ovulation in the cow.
Indomethacin or saline was administered via intramuscular, intrauterine or intraovarian routes to dairy cows, within 24 h after standing oestrus was first observed. The incidence of ovulation was determined at slaughter. All of the saline-treated cows (18/18) ovulated. Ovulation was not blocked after intramuscular injection (0/6) or intrauterine infusion (0/6) of indomethacin. In all cows, ovulation was blocked after intraovarian injection (6/6) of indomethacin. These findings add support to the hypothesis that prostaglandins play an essential role in ovulation in the cow as in many other mammalian species.
D000818:Animals; D002417:Cattle; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology; D007273:Injections, Intramuscular; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
D007213:Indomethacin