title: The influence of moderate-intensity noise on the compound action potential evoked by tone bursts in the guinea pig, Cavia porcellus.
abstract: Noise-induced changes in the compound action potential (CAP) evoked by tone bursts in the frequency range 0.5-24 kHz were studied in 15 pigmented guinea pigs by means of chronically implanted electrodes positioned near the round window. The animals were exposed for 120 h to continuous pink noise at the intensities 80, 90 and 100 dB SPL. During the exposure period, all the animals exhibited an exponential rise in CAP threshold, leveling out after 24-72 h (asymptotic threshold shift, ATS). The largest threshold shifts were recorded during exposure to 100 dB SPL, for frequencies in the range 8-12 kHz. In the recovery phase, after the end of noise exposure, the threshold to tones at all frequencies tested fell exponentially, reaching the original level in about 72 h in all cases.
mesh_terms: D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D008144:Loudness Perception / Q000502:physiology; D009622:Noise / Q000009:adverse effects; D010898:Pitch Perception / Q000502:physiology*; D000159:Vestibulocochlear Nerve / Q000503:physiopathology*