title: A field trial to assess the therapeutic and prophylactic effect of a foot rot vaccine in sheep.
abstract: An 18-week field trial was conducted on a sheep ranch to evaluate the therapeutic and prophylactic effect of a commercial foot rot vaccine. Two hundred sheep were included in the study, 100 with detectable foot rot lesions and 100 without. Approximately 50 sheep from each group were selected randomly and vaccinated twice against foot rot at a 6-week interval in the late spring 1984; the remaining sheep acted as nonvaccinated controls. Therapeutic effect of the vaccine was demonstrated by a cure rate of 53% in vaccinated, foot rot-affected sheep vs a cure rate of 19% in nonvaccinated, foot rot-affected sheep. Prophylactic effect of the vaccine was demonstrated by a foot rot prevalence at the end of the 18-week period of 9% for vaccinated sheep vs 53% for nonvaccinated sheep. Associations of foot rot lesions and vaccination with body condition were found to be significant, as was the association between foot rot lesions and mortality.
mesh_terms: D000818:Animals; D005260:Female; D005534:Foot Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary*; D007167:Immunotherapy; D012306:Risk; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D014612:Vaccines
chemical_list: D014612:Vaccines