Adrenal scintigraphy with 75Se selenonorcholestenol: a review.
We have reviewed 58 patients on whom adrenal scintigraphy has been performed using 75Se selenonorcholestenol. For 15 patients whose adrenal function was biochemically normal, the upper limit of normal of the 7 day adrenal uptake test was 0.45%, considerably higher than the generally accepted value of 0.3%. There is evidence from this group of patients that stress and obesity might account for uptakes in the range 0.3-0.45%. The sensitivity of the uptake test is poor, with 7 out of 23 patients with Cushing's syndrome having uptakes within the normal range. Scintigraphy of such patients may still be useful in differentiating between unilateral and bilateral adrenal involvement.
D000302:Adrenal Cortex / Q000000981:diagnostic imaging; D000303:Adrenal Cortex Diseases / Q000000981:diagnostic imaging*; D000306:Adrenal Cortex Neoplasms / Q000000981:diagnostic imaging; D000312:Adrenal Hyperplasia, Congenital / Q000000981:diagnostic imaging; D002784:Cholesterol / Q000031:analogs & derivatives; D003480:Cushing Syndrome / Q000000981:diagnostic imaging; D006801:Humans; D006929:Hyperaldosteronism / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D012643:Selenium
C016726:selenonorcholesterol; D002784:Cholesterol; D012643:Selenium