[Plasmapheresis in the treatment of pemphigus].
The results of small-volume plasmapheresis were favorable in cases of severe pemphigus vulgaris and foliaceus if applied simultaneously together with corticosteroids and cyclophosphamide, both on lowered doses. The patients went into long-lasting remission. A special indication for this therapy are cases that do not allow the application of large doses of prednison because of severe side-effects of steroids. The effect of plasmapheresis does not appear to depend on the removal large quantity of antibodies. Small-volume plasmapheresis as a supplementary therapy of the combined treatment with steroids and immuno-suppressors showed better effects than large-volume plasmapheresis.
D000328:Adult; D000906:Antibodies / Q000032:analysis; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods; D011241:Prednisone / Q000627:therapeutic use
D000906:Antibodies; D003520:Cyclophosphamide; D011241:Prednisone
Plasmapheresebehandlung bei Pemphigus.