[Induction of mutations resistant to 6-thioguanine by fast neutrons in cultured Chinese hamster cells].
A study was made of induction of mutations, resistant to 6-thioguanine (TGr), and reproductive death of Chinese hamster cells after irradiation by fission-spectrum fast neutrons (mean energy of 0.75 MeV) with doses of 10-130 cGy. A high relative biological effectiveness (RBE) of fast neutrons was shown. The maximum RBE values (13-16) were within the dose range inducing minimum mutagenic and lethal effects. RBE decreased with the dose increase. Inspite of high mutagenic effectiveness of neutrons, estimated according to TGr mutation frequency per cell per dose unit, their relative mutagenic effectiveness, estimated per cell per one lethal event, did not substantially differ from that of X-radiation.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D066298:In Vitro Techniques; D009154:Mutation; D009502:Neutrons; D011831:Radiation Genetics; D012062:Relative Biological Effectiveness; D013866:Thioguanine / Q000494:pharmacology*
D013866:Thioguanine
Induktsiia mutatsiĭ rezistentnosti k 6-tioguaninu bystrymi neĭtronami v kul'ture kletok kitaĭskogo khomiachika.