title: Topographical distribution of barrier function in cervico-cephalic arteries of dog. Major cerebral arteries possess definite barrier function?
abstract: Topographic distribution of barrier function in normal canine cervico-cephalic arteries was studied using horseradish peroxidase (HRP) and Evans blue as tracers. The carotid sinus of the internal carotid artery (ICA) was conspicuously permeable to HRP when compared to other areas of major cervical arteries. The cavernous portion of the ICA also showed prominent permeation of HRP, especially through the outer surface, which is covered with venous endothelial cells. On the luminal side of the cavernous portion of the ICA, barrier deficiency was noted at angulated segments such as the carotid siphon. Intracranial segments of both ICA and vertebral arteries demonstrated incomplete barrier function of the first 1 to 4 mm from the origin of the intradural segments. These areas were considered to be transitional sites in barrier function between extra- and intracranial arteries. Focal, but definite, barrier disruption was also noted at the distal ends of the ICA and other arterial branching sites of major intracranial arteries. While opening of the interendothelial junctions was considered to be one of the mechanisms causing increased permeability in the cavernous ICA, the mechanisms for the permeation of HRP into the major cerebral arteries could not be confirmed ultrastructurally.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002196:Capillaries / Q000502:physiology / Q000648:ultrastructure; D002339:Carotid Arteries / Q000502:physiology*; D002343:Carotid Artery, Internal / Q000502:physiology; D002536:Cerebral Arteries / Q000502:physiology* / Q000648:ultrastructure; D004285:Dogs; D005070:Evans Blue; D005260:Female; D006735:Horseradish Peroxidase; D009333:Neck / Q000098:blood supply
chemical_list: D005070:Evans Blue; D006735:Horseradish Peroxidase