title: [Effect of ethanol on the hepatocarcinogenic action of N-nitrosodiethylamine in rats].
abstract: It is shown that the administration of ethanol to male Wistar rats (3 g/kg by gastric tube 3 times a week for 2 months) before or at the beginning of the N-nitrosodiethylamine (NDEA) treatment (2.5 mg/kg 6 times a week in drinking water) reduces the hepatocarcinogenicity of NDEA. This was expressed macroscopically by less important neoplastic changes and biochemically by the higher glucose-6-phosphatase and lower glucose-6-phosphate dehydrogenase activities in the liver.
mesh_terms: D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology*; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004052:Diethylnitrosamine; D000431:Ethanol
vernacular_title: Vliianie étanola na gepatokantserogennoe deĭstvie N-nitrozodiétilamina u krys.