Fluoridation of drinking water: effects on kidney stone formation.
The influence of fluoride in drinking water on stone formation was studied in animals and in "in vitro" crystallization experiments. In male Wistar rats fluoride inhibits ethylenglycol induced calcification of the kidneys and stone formation. The in vitro results performed in synthetic urine exhibited a dose-dependent delay of crystal growth.
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000652:urine; D003460:Crystallization; D005026:Ethylene Glycols / Q000633:toxicity; D005457:Fluoridation; D005459:Fluorides / Q000009:adverse effects* / Q000378:metabolism / Q000652:urine; D007668:Kidney / Q000378:metabolism; D007669:Kidney Calculi / Q000139:chemically induced*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005026:Ethylene Glycols; D005459:Fluorides; D002118:Calcium