Adrenoreactivity of the circulatory system and of some metabolic processes induced by narcosis and surgical trauma.
Adrenal reactivity of the circulation and of several metabolic and regulatory systems, which had been induced by narcosis and surgical trauma, was studied on 50 mongrel dogs. Operative trauma (thoracotomy) done under thiopental sodium narcosis was accompanied with the moderately elevated adrenal reactivity of the circulation and essentially unchanged metabolic processes. Changes in the cardiac contractility and pump function induced by catecholamines are mediated through cardiac and vascular beta-adrenergic mechanism. These metabolic changes are determined by the state of adrenergic mechanisms. At the same time there is no distinct correlation between these changes and beta-adrenoreceptor state.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D002395:Catecholamines / Q000097:blood; D004285:Dogs; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000502:physiology*; D013874:Thiopental / Q000494:pharmacology*; D013903:Thoracic Surgery
D002395:Catecholamines; D011941:Receptors, Adrenergic; D005954:Glucosephosphate Dehydrogenase; D013874:Thiopental; D009638:Norepinephrine