title: Synthesis and analgesic properties of N-phosphorylated derivatives of Phe-Ala and Phe-Gly.
abstract: N-Phosphoryl dipeptides derived from Phe-Ala, Phe-Ala-NH2 and Phe-Gly-NH2 were synthesized and their analgesic activity was evaluated in mice. Intracerebroventricular administration of P-Phe-Ala-NH2 produced a 100-fold increase in the analgesic potency of Phe-Ala and led to a potentiation and prolongation of the analgesic effect of the exogenously administered Met-enkephalin.
mesh_terms: D000409:Alanine; D000698:Analgesia; D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D001681:Biological Assay; D004151:Dipeptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D005998:Glycine; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010649:Phenylalanine; D010748:Phosphopeptides / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D004151:Dipeptides; D010748:Phosphopeptides; D010649:Phenylalanine; D000409:Alanine; D005998:Glycine