Host antigens associated with haemagglutinin.
A delayed-type hypersensitivity (DTH) test has been used to detect the presence of host-specific antigen(s) is highly purified egg-grown influenza virus, virus components and isolated haemagglutinin. Cyclophosphamide-treated mice, primed with an extract from allantoic fluid, showed DTH reactions when challenged with preparations containing envelope lipid or polymer-type subunits, whereas lipid-free derivatives such as internal virus protein complexes and monomer haemagglutinin preparations lacked the activity. This approach has been extended to demonstrate the presence of associated host antigens in SV40-vector expressed haemagglutinin produced in simian cells.
D000482:Allantois / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D002460:Cell Line; D002642:Chick Embryo; D002522:Chlorocebus aethiops; D003429:Cross Reactions; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006968:Hypersensitivity, Delayed; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology*; D014776:Virus Cultivation
D000941:Antigens; D006389:Hemagglutinins, Viral