Characterization of the antihypoxic activity of tisochromid.
The antihypoxic activity of tisochromid is compared with the well-known restituting effect of piracetam on posthypoxic dopamine release inhibition. In addition to a distinct restituting effect which accelerates the normalization of dopamine release highly, tisochromid exhibits obviously an antioxidative potency which is responsible for a greater effectiveness of the drug when given prehypoxically. Therefore, tisochromid acts simultaneously as a protective and a restituting drug.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D066298:In Vitro Techniques; D010075:Oxathiins / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D006571:Heterocyclic Compounds; D010075:Oxathiins; C022101:tisocromide; D004298:Dopamine; D010889:Piracetam