title: Intravenous anaesthesia and the need for new agents.
abstract: Ideally one would like a water-soluble, non-irritant, rapidly-acting, smooth induction agent, with no antanalgesic action. Cardiovascular and respiratory depression should be minimal with normal dosage. Since these are unlikely to be achieved with a single drug, the combination of opioid and induction agent offers possibilities that should be explored. A slight delay in onset would not be a major obstacle, provided this is predictable, but the prime need is for a rapidly acting less toxic alternative to thiopentone.
mesh_terms: D000771:Anesthesia, Intravenous; D001463:Barbiturates / Q000009:adverse effects; D001569:Benzodiazepines / Q000009:adverse effects; D006801:Humans; D007649:Ketamine / Q000009:adverse effects; D013874:Thiopental / Q000009:adverse effects; D013997:Time Factors
chemical_list: D001463:Barbiturates; D001569:Benzodiazepines; D007649:Ketamine; D013874:Thiopental