Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats.
Cardiovascular responses to intravenous 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (56 and 112 pmoles/kg/min) were examined in conscious Wistar-Kyoto (WKY) normotensive rats and spontaneously hypertensive rats (SHR) instrumented with arterial and venous catheters, and an electromagnetic flow probe around the ascending aorta. The results suggest that this compound reduces mean blood pressure via a dose related fall in peripheral vascular resistance and cardiac index in conscious SHR and WKY rats.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology*; D007263:Infusions, Parenteral; D008297:Male; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014655:Vascular Resistance / Q000187:drug effects*
D000959:Antihypertensive Agents; D010972:Platelet Activating Factor; C037145:1-hexadecyl-2-acetyl-glycero-3-phosphocholine