title: Results of microsurgery in Cushing's disease and effect on hypertension.
abstract: In 100 consecutive transnasal sellar explorations in suspected Cushing's disease, 88 pituitary adenomas were removed. The initial remission rate in adenoma cases was about 90%. Complications related to surgery had been rare. Regularly after complete selective adenomectomy a period of ACTH and cortisol deficiency was found (90%). In these patients only 1 recurrence was seen whereas from 5 patients without cortisol deficit a relapse occurred in 4. Hypertension was found in 80% of patients with verified Cushing's disease. With normalization of cortisol excess, hypertension disappeared in 75% and was ameliorated in 15%.
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000601:surgery*; D000236:Adenoma / Q000601:surgery*; D001794:Blood Pressure; D003480:Cushing Syndrome / Q000601:surgery*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000601:surgery*; D008866:Microsurgery; D009384:Paraneoplastic Endocrine Syndromes / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000601:surgery*; D012086:Reoperation
chemical_list: D006854:Hydrocortisone