Management of limited rhino-orbital mucormycosis without exenteration.
Eight cases of rhino-orbital mucormycosis managed successfully without exenteration were reviewed. The favorable outcome was attributable to early diagnosis and management of focal areas of fungus infection. Treatment included: correction of diabetic ketoacidosis or other concomitant metabolic derangement; wide local excision and debridement of all involved and devitalized oral, nasal, sinus, and orbital tissue, while establishing adequate sinus and orbital drainage; daily irrigation and packing of the involved orbital and paranasal areas with amphotericin B; and intravenous amphotericin B. This represents the largest reported series of rhino-orbital mucormycosis survivors without mutilating surgery and with unaltered visual acuity.
D000328:Adult; D000368:Aged; D048909:Diabetes Complications; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D009668:Nose Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D009916:Orbital Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000209:etiology; D014057:Tomography, X-Ray Computed; D014785:Vision, Ocular