Iron deficiency in the rat: effects on energy metabolism in brown adipose tissue.
Mitochondria were prepared from the brown adipose tissue of control rats and animals made iron deficient by means of a low iron diet. The specific activities of the mitochondrial electron transport system (NADH, succinate and alpha-glycerophosphate oxidase activities) were markedly and significantly reduced in preparations of brown adipose tissue from the iron-deficient rats as compared with preparations from the control animals. In contrast, concentrations of the cytochrome pigments a + a3, and c + c1 were normal and cytochrome b was slightly reduced (18%) in the mitochondrial preparations from the iron-deficient animals. Treatment of the iron-deficient animals with triiodothyronine significantly increased the amount of brown fat present per kilogram of body weight in both control and iron-deficient rats, but did not significantly affect the specific activities of the mitochondrial electron transport system.
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D001833:Body Temperature Regulation; D004579:Electron Transport; D066298:In Vitro Techniques; D000090463:Iron Deficiencies; D008297:Male; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D014284:Triiodothyronine / Q000008:administration & dosage
D014284:Triiodothyronine