The effect of cimetidine on the formation of methoxyflurane fluorometabolites in mice.
Pre-dosing of mice with cimetidine reduced the plasma levels of inorganic fluoride, one of the fluorometabolites of methoxyflurane. The reduction occurred as early as 10 and as late as 160 minutes after cimetidine injection, and it was seen at both 30 and 100 minutes after subsequent methoxyflurane administration. Multiple pre-dosings with cimetidine did not notably affect the fluoride response. These results may be of use in avoiding methoxyflurane toxicity, which is thought to be due to markedly elevated fluoride levels in some patients.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005459:Fluorides / Q000378:metabolism*; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D008733:Methoxyflurane / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR
D008733:Methoxyflurane; D002927:Cimetidine; D005459:Fluorides