Neutralization of Chlamydia trachomatis cell culture infection by serovar-specific monoclonal antibodies.
Seventeen monoclonal antibodies (MAs) were tested. Five of seven serovar-specific MAs from five different serovars and two of five subspecies-specific MAs showed neutralizing activity as well as serovar specificity. No species- or genus-specific MAs showed neutralizing activity. No neutralization occurred without complement. Results indicate neutralization was serovar specific and complement dependent.
D000818:Animals; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology; D002692:Chlamydia trachomatis / Q000254:growth & development / Q000276:immunology*; D003429:Cross Reactions; D006367:HeLa Cells; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D051379:Mice; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial