The metabolism of dibenz[a,j]acridine in the isolated perfused lung.
The metabolism of the carcinogenic N-heterocyclic aromatic, dibenz[a,j]-acridine (DB[a,j]A), was investigated in an isolated perfused rabbit lung preparation. The rate of metabolism of DB[a,j]A was less than the rate of metabolism of 7H-dibenzo[c,g]carbazole (DB[c,g]C) in the untreated and corn oil-pretreated animals. A significantly increased rate of metabolism was observed for DB[a,j]A in benzo[a]pyrene(B[a]P)-pretreated animals. This resulted in marked increases in conjugation and distribution of conjugates and total metabolites in blood and lung. Two major metabolites characterized spectroscopically were assigned as the 3,4-dihydrodiol and a phenol of DB[a,j]A. The results indicate that in the lung DB[a,j]A is metabolized in a manner similar to that of B[a]P.
D000166:Acridines / Q000378:metabolism*; D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011817:Rabbits
D000166:Acridines; D002273:Carcinogens; C022289:dibenzacridine; D001564:Benzo(a)pyrene