The action spectrum for benzanthrone photosensitization of mouse macrophages.
An in vitro method for determination of the phototoxic action spectrum of benzanthrone was established using a cover slip-test tube culture system with mouse peritoneal macrophages. The action spectrum peaked between 380 and 400 nm with abrupt fall-off to either side. These findings correlate closely with both the absorption spectrum of benzanthrone and the clinical action spectrum of phototoxicity in humans.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003877:Dermatitis, Contact / Q000209:etiology; D006801:Humans; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D008813:Mice, Inbred ICR; D010777:Photochemistry; D013053:Spectrophotometry
D001551:Benz(a)Anthracenes; C012768:benzanthrone