title: Serum lipid and lipoprotein concentration in coronary heart disease.
abstract: The relationship between serum lipid and lipoprotein concentration and the severity of coronary artery disease assessed by cineangiography was studied in 38 male patients, aged 44 +/- 11.5 years. According to luminal diameter narrowing of 3 major coronary arteries, the patients were divided into 3 groups: group A -- 10 patients with a normal coronarographic finding; group B -- 8 patients with a 26 to 50% coronary artery stenosis; group C -- 20 men with coronary stenosis exceeding 51%. With the exception of Apo B which in patients of group B was slightly elevated (p less than 0.05), there was no difference in serum lipid and lipoprotein levels between patients of group A and B. Patients of group C had significantly increased Apo B and triglyceride levels and a decreased high density lipoproteins (HDL) cholesterol/total cholesterol ratio in comparison with the control group. In group C, a linear correlation was found between the number of affected major coronary arteries and the serum Apo B level. The results suggest that determination of Apo B, triglycerides and the HDL cholesterol/total cholesterol ratio contributes to assessing the severity of coronary heart disease.
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001055:Apolipoproteins B; D008055:Lipids; D008074:Lipoproteins