Pyruvate and related alpha-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity.
Pyruvate efficiently protected V79 Chinese hamster cells against the lethal effects of hydrogen peroxide. Protection was also provided by other alpha-ketoacids, such as alpha-ketobutyrate, alpha-ketoglutarate and alpha-ketoadipate, although higher concentrations were required. The corresponding beta-ketoacids had no effect. The results indicate that pyruvate and other alpha-ketoacids possess antioxidant activity in vitro and, probably, in vivo.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D006861:Hydrogen Peroxide / Q000633:toxicity*; D007651:Keto Acids / Q000494:pharmacology*; D011773:Pyruvates / Q000494:pharmacology*; D019289:Pyruvic Acid
D000975:Antioxidants; D007651:Keto Acids; D011773:Pyruvates; D019289:Pyruvic Acid; D006861:Hydrogen Peroxide