[Neutrophil-stimulating activity of staphylococci based on reactive chemiluminescence data].
The neutrophil-stimulating properties of 38 S. aureus strains and 32 S. epidermidis strains were studied in the reaction of luminol-mediated chemiluminescence. All S. aureus strains and 29 S. epidermidis strains were found to possess neutrophil-stimulating activity, the mean activity index for S. aureus being significantly higher. The stimulating activity of the strains varied within a wide range (the variation coefficient was 120.0 +/- 21.9%) and did not correlate with the content of protein A in bacterial cells and the degree of their hydrophoby. The opsonization of staphylococci with normal human serum enhanced the neutrophil reaction 1.5- to 100-fold and simultaneously leveled out the chemiluminescence indices in experiments with different strains (the variation coefficient was 8.0 +/- 1.5%). The nature of the neutrophil-stimulating effect of staphylococci and its relationship to the exploratory reactions of phagocytes are discussed.
D000328:Adult; D002478:Cells, Cultured; D006801:Humans; D008163:Luminescent Measurements; D008213:Lymphocyte Activation; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D009895:Opsonin Proteins / Q000276:immunology; D010100:Oxygen / Q000097:blood; D013045:Species Specificity; D013205:Staphylococcal Protein A / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*; D013212:Staphylococcus epidermidis / Q000276:immunology*
D009895:Opsonin Proteins; D013205:Staphylococcal Protein A; D010100:Oxygen
Neĭtrofilstimuliruiushchaia aktivnost' stafilokokkov po dannym reaktivnoĭ khemiliuminestsentsii.