Micro-angiopathic haemolytic anaemia and an unusual lactate dehydrogenase iso-enzyme pattern in metastatic adenocarcinoma. A case report.
Micro-angiopathic haemolytic anaemia is an unusual but well-recognized complication of metastatic adenocarcinoma. A young black man presented with red cell fragmentation, compensated disseminated intravascular coagulation and leuco-erythroblastosis. Metastatic adenocarcinoma of the stomach was suspected but only demonstrated at autopsy. An unusual finding was the elevation of the slow-moving lactate dehydrogenase iso-enzyme (LDH5) level in the plasma which was shown to be produced by metastatic tumour cells recovered from the bone marrow.
D000230:Adenocarcinoma / Q000150:complications* / Q000201:enzymology / Q000556:secondary; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D013274:Stomach Neoplasms / Q000150:complications* / Q000201:enzymology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase