title: [Creatine kinase BB activity in the serum of patients with cerebrovascular diseases].
abstract: There are conflicting reports of an increase in the activity of creatine kinase BB isoenzyme (CK-BB) in the serum of patients with cerebrovascular disease. The serum CK-BB activity of 33 patients with ischemic brain infarction, subarachnoid hemorrhage or intracerebral hemorrhage was measured with a bioluminescence method (CK-B Kit, LKB-Wallac) in combination with immunoprecipitation. The results were compared with lesions determined by computed tomography. In the control group (N = 19) there was a mean activity of 0.35 +/- 0.26 U/l (means +/- SE). In patients with small lesions (N = 11) the activity was 0.41 +/- 0.21 U/l, which was not significantly elevated when compared to the control group (Mann/Whitney U test). Therefore, patients with more extensive lesions (N = 12) and the group with severe lesions (N = 10) showed a significant elevation, with a mean activity of 0.61 +/- 0.34 U/l and 1.12 +/- 0.52 U/l, respectively. The group with severe lesions had a maximum activity on the first day after the initial symptoms.
mesh_terms: D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000201:enzymology; D002544:Cerebral Infarction / Q000201:enzymology; D002561:Cerebrovascular Disorders / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase
vernacular_title: Kreatinkinase-BB-Aktivität im Serum bei Patienten mit cerebrovaskulären Erkrankungen.