title: Rectal premedication in children. Comparison of diazepam with a mixture of morphine, scopolamine and diazepam.
abstract: Two hundred and eight healthy children who were to undergo minor elective surgery during halothane, nitrous oxide, oxygen anaesthesia were studied in a double blind investigation to evaluate the sedative and anticholinergic effects of two rectal premedications. Group I received diazepam 0.75 mg/kg rectally; Group II received a mixture of diazepam 0.5 mg/kg, morphine 0.15 mg/kg and hyoscine 0.01 mg/kg rectally. No significant difference was found between the two groups in sedative or anticholinergic effects during induction of anaesthesia or in the postoperative period. No adverse effects were seen.
mesh_terms: D000293:Adolescent; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007223:Infant; D009020:Morphine / Q000008:administration & dosage*; D010276:Parasympatholytics / Q000494:pharmacology; D011229:Preanesthetic Medication; D012007:Rectum; D012601:Scopolamine / Q000008:administration & dosage*
chemical_list: D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D009020:Morphine; D012601:Scopolamine; D003975:Diazepam