title: Adrenoleukodystrophy: fatty acid analysis of total glycerophospholipids in erythrocyte membranes.
abstract: The saturated fatty acids released from the erythrocyte membranes of four patients with adrenoleukodystrophy (ALD) and 14 diseased controls were analyzed by high performance liquid chromatography. The ratios of C26:0 to other saturated fatty acids in ALD were higher than those of diseased controls, and neither false-positive nor false-negative samples were observed. These results suggest that a study of fatty acids of total glycerophospholipids in erythrocyte membranes by high performance liquid chromatography is a useful diagnostic method of ALD.
mesh_terms: D000326:Adrenoleukodystrophy / Q000097:blood*; D000328:Adult; D002547:Cerebral Palsy / Q000097:blood; D055598:Chemical Phenomena; D002621:Chemistry; D002648:Child; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000097:blood*; D004910:Erythrocyte Membrane / Q000032:analysis*; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D009136:Muscular Dystrophies / Q000097:blood; D010712:Phosphatidic Acids / Q000097:blood*
chemical_list: D005227:Fatty Acids; D008563:Membrane Lipids; D010712:Phosphatidic Acids