Ketone-body metabolism after partial hepatectomy in the rat.
Fed or 24 h-starved rats were subjected to two-thirds partial hepatectomy or sham-operation and subsequently starved for 4, 14 or 24 h. Despite high plasma fatty acid concentrations, the partially hepatectomized rats failed to respond to post-operative starvation with increased blood and liver ketone-body concentrations or to maintain the high ketone-body concentrations associated with pre-operative starvation. Hypoglycaemia and hyperlactaemia were observed within 30 min of functional hepatectomy, but not partial hepatectomy, of 24 h-starved rats, and, even after a further 24 h starvation of partially hepatectomized rats, blood glucose concentrations were only slightly decreased. The results are discussed with reference to fat oxidation and gluconeogenesis in the liver remaining after partial hepatectomy.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006498:Hepatectomy; D007657:Ketone Bodies / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D014280:Triglycerides