Heparinizable graft copolymers from chlorosulphonated polyethylene with poly(amido-amine) segments.
The synthesis and the physical characterization of three graft copolymers (PES/PAA) obtained from chlorosulphonated polyethylene (PECS) and three different secondary amino end-capped poly(amido-amine)s are reported. The properties of these heparinizable materials appear to be suitable for constructing prosthetic devices for biomedical use. The heparin adsorbing ability and the stability of the complex with heparin of the three copolymers have been evaluated, by means of biological tests, as activated Partial Thromboplastin Time (PTT) and Thrombin Time (TT).
D000327:Adsorption; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D055598:Chemical Phenomena; D002621:Chemistry; D006493:Heparin; D009757:Nylons; D011073:Polyamines; D011095:Polyethylenes; D011108:Polymers / Q000138:chemical synthesis*; D019736:Prostheses and Implants; D013451:Sulfonic Acids
D001672:Biocompatible Materials; D009757:Nylons; D011073:Polyamines; D011095:Polyethylenes; D011108:Polymers; D013451:Sulfonic Acids; D006493:Heparin