Severe, acute propoxyphene overdose treated with dopamine.
Six patients suffering from cardiovascular failure due to acute propoxyphene overdose, were treated with dopamine infusion in doses of 2-17 microgram/kg/min. All patients responded with increased systolic arterial blood pressure, increased urinary output and decreased central venous pressure. The two most severely poisoned patients showed no increase in heart rate in spite of dopamine infusion in positively chronotropic doses. In two out of three patients the initially abnormal ECGs normalised during treatment. It is concluded that dopamine seems suitable for reversal of propoxyphene induced circulatory failure.
D000208:Acute Disease; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D011431:Dextropropoxyphene / Q000506:poisoning*; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D011431:Dextropropoxyphene; D004298:Dopamine