Indirect adrenergic effect of compound 48/80 in cat cerebral arteries.
Compound 48/80 evoked an increase in the spontaneous tritium release from cat cerebral arteries prelabelled with 3H-NA. This increase was abolished after cervical gangliectomy, external calcium removal or in the presence of colchicine. Cocaine brought about an enhancement in the release of radioactivity elicited by compound 48/80 while diphenhydramine did not affect it. These results suggest that compound 48/80 has an indirect adrenergic effect in cat cerebral arteries which is not mediated by the release of histamine from mast cells.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D014316:Tritium; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D014316:Tritium; D003189:p-Methoxy-N-methylphenethylamine; D004155:Diphenhydramine; D003042:Cocaine; D003078:Colchicine; D002118:Calcium; D009638:Norepinephrine