Detection of incompletely sialylated human chorionic gonadotropin by peanut agglutinin in choriocarcinoma.
Human chorionic gonadotropin (hCG) in normal pregnancy and hydatidiform mole did not bind to the peanut agglutinin (PNA)-Sepharose column, whereas significant amount of hCG in choriocarcinoma adsorbed to the column. Therefore, PNA-Sepharose affinity chromatography is an effective tool for the detection of desialylated hCG and may be useful also for the diagnosis of choriocarcinoma.
D010367:Arachis; D002822:Choriocarcinoma / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000032:analysis*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000032:analysis; D037102:Lectins; D046911:Macromolecular Substances; D019887:Peanut Agglutinin; D037121:Plant Lectins; D011247:Pregnancy; D012794:Sialic Acids / Q000032:analysis*; D014594:Uterine Neoplasms / Q000032:analysis*
D006063:Chorionic Gonadotropin; D037102:Lectins; D046911:Macromolecular Substances; D019887:Peanut Agglutinin; D037121:Plant Lectins; D012794:Sialic Acids