[Estimation of the frequency of amino acid substitutions causing instability of the spatial structure in an overall mutation spectrum of alpha- and beta-subunits of human hemoglobin].
The influence of single amino acid substitutions on the stability of alpha- and beta-chains of human hemoglobin was investigated by the computer method. The method was based on characteristics of protein tertiary structure and physico-chemical properties of amino acids. Frequencies of unstable mutations in the total mutational spectra of alpha- and beta-subunits of human hemoglobin were analysed: instability was produced by 26% of mutations in the alpha-subunit and by 32% in the beta-subunit. These results support the idea that certain limitations exist for stability changes produced by amino acid substitutions.
D000595:Amino Acid Sequence; D005914:Globins / Q000235:genetics; D006441:Hemoglobin A / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation
D006455:Hemoglobins, Abnormal; D005914:Globins; D006441:Hemoglobin A
Otsenka chastoty odinochnykh aminokislotnykh zamen, vyzyvaiushchikh nestabil'nost' prostranstvennoĭ struktury, v polnykh mutatsionnykh spektrakh alpha- i beta-sub''edinits gemoglobina cheloveka.