Inhibition of human glutathione S-transferases by 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T).
The phenoxyacid herbicides, 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T), inhibit all known isoenzymes of human liver and erythrocyte glutathione (GSH) S-transferase. However, the maximal inhibition and the I50 values vary significantly for different isoenzymes. GSH peroxidase II activity of GSH S-transferases is also inhibited by both these compounds. These studies suggest that the effect of these compounds on human GSH S-transferases is significantly different from that reported for rat liver enzymes.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000494:pharmacology*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology
D015084:2,4-Dichlorophenoxyacetic Acid; D015085:2,4,5-Trichlorophenoxyacetic Acid; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase