[Free thymidine in the blood serum of irradiated rats with different levels of cellular depletion of the thymus and spleen].
The levels of the postirradiation thymidinemia, with an equal degree of the proceeding cell depletion of lymphoid organ tissues caused by the administration of dexamethasone and exposure of rats to 3 Gy radiation, markedly varied. Three days after the injection of the hormone, the organism responded to irradiation by an increase in the concentration of thymidine in blood serum in the same manner as intact animals did. The preirradiation with a dose of 3 Gy reduced sharply the ability of the organism to respond the repeated irradiation (after 3 days) by thymidinemia. There was a lesser increase in the thymidine concentration in the blood after the injection of dexamethasone than after irradiation inducing the same cell depletion of the thymus and spleen.
D000818:Animals; D003037:Cobalt Radioisotopes; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005720:Gamma Rays; D011833:Radiation Injuries, Experimental / Q000097:blood*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D013936:Thymidine / Q000097:blood*; D013950:Thymus Gland / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
D003037:Cobalt Radioisotopes; D003907:Dexamethasone; D013936:Thymidine
Svobodnyĭ timidin v syvorotke krovi obluchennykh krys pri raznykh urovniakh kletochnogo opustosheniia timusa i selezenki.