title: Efficacy of fenbendazole and cambendazole against Muellerius capillaris in dairy goats.
abstract: Two anthelmintics, fenbendazole and cambendazole, were used in an attempt to eliminate Muellerius capillaris infections in a group of 44 goats. During the course of this study (508 days), M capillaris larvae were found in at least one fecal specimen from each of 22 of the 44 goats. All 44 goats were dewormed with fenbendazole (30 mg/kg of body weight) at the onset of this study (day 18). Two additional dewormings with fenbendazole at 4- to 8-week intervals were restricted to the goats that continued to shed M capillaris larvae. On the basis of routine fecal examinations, fenbendazole eliminated M capillaris larvae from the feces of 8 (36%) of these 22 goats. On day 253, cambendazole (60 mg/kg) was given orally to 17 of these 22 goats (2 of the 22 had died and 3 were not available for treatment); 13 of these goats were still shedding M capillaris larvae. Cambendazole eliminated M capillaris larvae from the feces of 10 (77%) of these 13 goats chronically infected with M capillaris.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D002159:Cambendazole / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use*; D006041:Goats; D007814:Larva / Q000302:isolation & purification; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009348:Nematoda / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D001562:Benzimidazoles; D002159:Cambendazole; D005273:Fenbendazole