Enhancement of dengue virus infection in cultured mouse macrophages by lipophilic derivatives of muramyl peptides.
Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D002473:Cell Wall / Q000502:physiology; D002478:Cells, Cultured; D003716:Dengue Virus / Q000254:growth & development*; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine