Brain, spinal cord and adrenal catecholamine concentrations in neonate rats of the Lyon hypertensive strain.
The catecholamine concentrations were determined in brain parts, spinal cord and adrenals of neonate hypertensive rats of the Lyon strain (LH), compared to normotensive (LN) and low-blood-pressure (LL) control rats. In adrenals of LH rats, noradrenaline and adrenaline concentrations are increased, and 3,4-dihydroxyphenylacetic acid (DOPAC) concentration decreased. At the central level, the DOPAC concentration and the ratio DOPAC/dopamine are decreased in the mesencephalon and the forebrain of LH rats. These results suggest that neonate LH rats exhibit a decreased activity in central dopaminergic neurons, and an enhanced maturation of the adrenals.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000313:Adrenal Medulla / Q000032:analysis*; D000818:Animals; D002395:Catecholamines / Q000032:analysis*; D002490:Central Nervous System / Q000032:analysis*; D004298:Dopamine / Q000032:analysis; D005260:Female; D006973:Hypertension / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008636:Mesencephalon / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D051381:Rats
D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D009638:Norepinephrine