[The paramyosin function in glycerinated muscle fibers during blocking with antibodies of its contacts with structural proteins].
Antibodies to paramyosin (APM) induce a partial decrease of the isometric tension in glycerinated fibres of the Anodonta cygnea catch muscle in the presence of ATP and Ca2+; the myofibrillar Mg2+ ATPase increases concomitantly. Assumedly paramyosin inhibits the cross-bridges unlocking, retaining them mechanically in a locked state. The fibres of barnacle giant muscle in an ATP deficient solution respond to APM by transient isometric tension development. A model for the participation of paramyosin in the contractile process is proposed. In both muscle types paramyosin hinders the functioning of certain elements of the contractile machinery.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001667:Binding, Competitive; D049872:Bivalvia; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D009218:Myosins / Q000378:metabolism*; D001468:Thoracica; D014335:Tropomyosin / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D014335:Tropomyosin; D000255:Adenosine Triphosphate; D009218:Myosins
Izuchenie funktsii paramiozina v glitserinizirovannykh voloknankh myshts pri blokirovanii antitelami ego kontaktov so strukturnymi belkami.