Nerve grafting. Functional results after primary vs delayed repair.
The finding of heightened metabolic activity in nerve cell bodies after axonal injury has led to speculation that delaying motor nerve repair would be beneficial. Using a sciatic nerve model, 100 rats were grouped based on nerve autograft donor and recipient site variables. Animals were subjected to electrophysiologic testing at 3, 6, 9, and 12 weeks after grafting. Twitch force and nerve compound action potential parameters were calculated and compared using two-way analysis of variance. Previous studies have suggested interaction between donor and recipient variables. We cannot support these findings. Our data revealed no significant difference between immediate or delayed nerve repair or between fresh or predegenerated nerve grafts.
D000200:Action Potentials; D000818:Animals; D001369:Axons / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D008959:Models, Neurological; D009119:Muscle Contraction; D009132:Muscles / Q000294:innervation*; D009416:Nerve Regeneration; D009431:Neural Conduction; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000502:physiology / Q000601:surgery / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous