Comparison of the serum pharmacokinetics of a long acting and a conventional oxytetracycline injection.
A crossover study was carried out in cattle to determine the serum pharmacokinetics of a standard dose (20 mg/kg bodyweight) of oxytetracycline given either as a conventional injectable formulation or as a long acting formulation. For reference purposes, an intravenous treatment (also given at 20 mg/kg) was included in the trial protocol. A comparison of the two treatment regimes showed that the long acting formulation gave a significantly lower peak oxytetracycline serum concentration, with a significant extension of drug serum concentration. The long acting formulation also showed a longer serum half life and a significantly greater area under the curve value, calculated from 36 hours onwards, together with serum oxytetracycline concentrations which exceeded 0.5 microgram/ml for 86.8 as opposed to 51.5 hours for the conventional formulation. It is concluded that the use of the long acting formulation in cattle leads to a more sustained serum oxytetracycline concentration than does the same dose of conventional formulation.
D000818:Animals; D000829:Animals, Domestic / Q000097:blood*; D001682:Biological Availability; D002417:Cattle; D003692:Delayed-Action Preparations; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
D003692:Delayed-Action Preparations; D010118:Oxytetracycline