title: Rapid induction of extrapyramidal side effects with combined use of lithium and neuroleptics.
abstract: Various forms of toxicity have been described when lithium and neuroleptics are used in combination. Two cases are presented in which extrapyramidal symptoms appeared soon after lithium was added to a regimen of neuroleptics. Clinical variables and pathophysiologic mechanisms are discussed. This reaction warrants further investigation.
mesh_terms: D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D008297:Male
chemical_list: D008094:Lithium; D006220:Haloperidol; D002746:Chlorpromazine