Transient thrombocytopenia in systemic onset juvenile rheumatoid arthritis.
Three children have been presented who have had long-standing, typical systemic juvenile rheumatoid arthritis. They also had a transient illness with thrombocytopenia, antiplatelet antibodies, and the simultaneous appearance of anti-DNA antibodies and hypocomplementemia. Other single abnormalities included the development of a positive ANA, Coombs, and lupus bands test. All responded to high-dose steroid therapy. Their similar clinical and serologic findings are noteworthy and represent one of the numerous complications seen in patients with systemic juvenile rheumatoid arthritis.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D001171:Arthritis, Juvenile / Q000097:blood / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology / Q000628:therapy
D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D003165:Complement System Proteins