Recurrence of thymoma with appearance of myasthenia gravis 18 years after surgery: a case report.
A 59-year-old woman was admitted to the hospital because of recurrence of thymoma with appearance of myasthenia gravis 18 years after excision of an invasive thymoma. Recurrence was observed in the anterior mediastinum, right pleura, pericardium and left supraclavicular lymph node. Hashimoto's thyroiditis, vitiligo vulgaris and leukopenia were also seen. After creation of a pericardial window for pericardial effusion, she received vincristine, then carbazilquinone intravenously as single chemotherapeutic agents based on the chemosensitivity by clonogenic assay of the supraclavicular tumor, but response was not achieved. At one and a half years after radiotherapy to the mediastinum, she is now doing well without symptoms and is receiving a fairly low dose of anticholinesterase medication.
D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000209:etiology*; D009361:Neoplasm Invasiveness; D012008:Recurrence; D013945:Thymoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013953:Thymus Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors