title: Emetic effects of centrally administered angiotensin II, arginine vasopressin and neurotensin in the dog.
abstract: Short-latency emetic responses were induced in dogs by injecting angiotensin II (AII), arginine vasopressin (AVP), and neurotensin (NTN) into cerebroventricular (ICV) and cisternal (ICT) sites also responsive to the emetic effects of apomorphine (APO). Angiotensin III, bradykinin, bombesin, oxytocin, adrenocorticotropic hormone, substance P, gastrin-related peptide and cholecystokinin were ineffective. The results suggest a possible dopaminergic mediation of peptide-induced emesis by receptors in the area postrema (AP).
mesh_terms: D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004639:Emetics / Q000494:pharmacology; D007276:Injections, Intraventricular; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004639:Emetics; D000804:Angiotensin II; D001127:Arginine Vasopressin; D009496:Neurotensin