title: [Immune response of noninbred mice to subvirion influenza vaccines with various antigen and sorbent loads].
abstract: The variants of splitted and subunit influenza monovaccines from virus strains A/Leningrad/385/80R (H3N2) and A/Kiev/59/79R (H1N1), adsorbed on aluminium hydroxide and having the varying content of hemogglutinin and the carrier, have been studied. The immune response of noninbred mice to a single and double injections of these vaccines have been evaluated, the concentrations of the antigen and the carrier inducing a high response in the animals, have been determined. Differences in the immunological potency of hemagglutinins H1 and H3 have been noted.
mesh_terms: D000536:Aluminum Hydroxide / Q000276:immunology; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006389:Hemagglutinins, Viral / Q000276:immunology; D007164:Immunosorbents / Q000276:immunology*; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000276:immunology*; D051379:Mice; D014613:Vaccines, Attenuated / Q000276:immunology; D014771:Virion / Q000276:immunology*
chemical_list: D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D006389:Hemagglutinins, Viral; D007164:Immunosorbents; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D000536:Aluminum Hydroxide
vernacular_title: Izuchenie immunnogo otveta neinbrednykh mysheĭ na subvirionnye gripkoznye vaktsiny s var'iruemoĭ nagruzkoĭ antigena i sorbenta.