Treatment of oligozoospermia with tamoxifen (open and controlled studies).
Open and double-blind therapeutic studies were carried out on the effects of tamoxifen in oligozoospermia. The examinations involved 74 patients. The first group (n = 20) received tamoxifen 20 mg/day; the second group (n = 54) got tamoxifen or placebo for 3 months. In the open study, tamoxifen treatment led to significant increases in the spermatozoa concentration and the total sperm count, but this could not be confirmed with the double-blind set-up.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D011247:Pregnancy; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013629:Tamoxifen / Q000627:therapeutic use*
D013629:Tamoxifen