title: Necrobiotic xanthogranuloma with paraproteinaemia.
abstract: A 66-year-old man with necrobiotic xanthogranuloma associated with paraproteinaemia is described. He also had long-standing normolipaemic plane xanthomata. Treatment was with melphalan 0.15 mg/kg body weight/day. Initially, three 5-day courses were given at 4-weekly intervals but a fourth course was necessary after a further 4 months because of a deterioration in both his skin and associated systemic symptoms.
mesh_terms: D000368:Aged; D006099:Granuloma / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D009335:Necrobiosis Lipoidica / Q000150:complications* / Q000188:drug therapy; D014973:Xanthomatosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D007074:Immunoglobulin G; D008558:Melphalan