Effect of butorphanol tartrate on food and water consumption in humans.
There is much evidence that endogenous opioid peptides are involved in the regulation of food and water intake in a variety of species. We report here that the exogenous opiate agonist, butorphanol tartrate (1 microgram/kg), significantly increases food, but not water, intake in normal humans. The major effect on food intake was seen within the first 2 h after the administration of drug. These findings suggest that this drug may be therapeutically useful in patients with cancer anorexia.
D000328:Adult; D002077:Butorphanol / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects*; D002149:Energy Intake; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009019:Morphinans / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D012527:Satiation / Q000187:drug effects
D009019:Morphinans; D009270:Naloxone; D002077:Butorphanol