Cafeteria feeding promotes diet-induced thermogenesis in monosodium glutamate-treated mice.
We studied diet-induced thermogenesis (DIT) in cafeteria fed monosodium glutamate (MSG) and saline-treated mice. From 12 weeks of age MSG and saline-treated mice were fed a diet of either standard chow or a cafeteria diet of standard chow supplemented with chocolate or biscuits on alternate days for six weeks. There was a significant weight gain in cafeteria fed MSG-treated mice but not in cafeteria fed saline-treated mice. In cafeteria fed MSG-treated mice there was a significant increase in resting oxygen consumption. The response to exogenous norepinephrine was significantly increased in cafeteria fed saline-treated mice. The level of specific tritiated guanosine 5'-diphosphate binding to isolated mitochondrial fractions was significantly increased in both cafeteria fed MSG and saline-treated mice. It is concluded that (1) cafeteria feeding is capable of promoting DIT, within brown adipose tissue (BAT), in MSG-treated mice and (2) the mechanisms for the induction of thermoregulatory thermogenesis (TRT) and DIT are distinct since cold-induced TRT has previously been shown to be defective in MSG-treated mice.
D002001:Adipose Tissue, Brown / Q000187:drug effects*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004247:DNA / Q000378:metabolism; D004032:Diet; D002149:Energy Intake; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D006153:Guanosine Diphosphate / Q000378:metabolism; D050356:Lipid Metabolism; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D012970:Sodium Glutamate / Q000494:pharmacology*; D000090324:Tumor Protein, Translationally-Controlled 1
D005971:Glutamates; D011506:Proteins; C000715648:Tpt1 protein, mouse; D000090324:Tumor Protein, Translationally-Controlled 1; D006153:Guanosine Diphosphate; D004247:DNA; D012970:Sodium Glutamate; D009638:Norepinephrine