title: Shortening of the interoestrous interval and the lifespan of the corpus luteum of the cyclic dog by bromocryptine treatment.
abstract: Four beagle bitches were treated orally, twice daily with 250 micrograms bromocryptine, an inhibitor of prolactin secretion, from D1-D5 (D1 is defined as the first day of the luteal period) until the onset of the next prooestrus (n = 2) or the end of the luteal period (n = 2) of the following cycle. The mean interoestrous interval in the experimental group (123.3 +/- 23.1 day; n = 4) was significantly (p less than 0.001) shorter than the average of the mean values of the interoestrous interval (245.9 +/- 8.8 day; n = 36) of 10 control bitches. This shortening is mainly a consequence of a reduction to 35% of the anoestrous period of normally cyclic dogs. The luteal period of the first cycle was shortened to 78% compared with the luteal period of control dogs and this is also a contributing factor.
mesh_terms: D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects*; D004285:Dogs / Q000502:physiology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay / Q000662:veterinary; D013997:Time Factors
chemical_list: D001971:Bromocriptine; D011374:Progesterone; D011388:Prolactin