Centrocentral anastomosis in the prevention and treatment of painful terminal neuroma. An experimental study in the rat.
In this experimental study, microsurgical centrocentral anastomosis was applied to an experimental model of painful terminal neuroma resulting from left sciatic nerve section in the rat. The anastomosis consisted of end-to-end suturing of the sciatic nerve fascicles to the tibial branch, with the interposition of a nerve graft taken from the same anastomosed fascicle. As a control parameter for the experiment, the autotomy which follows sciatic nerve section in the rat was evaluated. Autotomy is considered an objective indication of abnormal sensations that are provoked by the formation of a terminal neuroma. Histological study of the proximal stump of the sciatic nerve was also performed. The observation period was 10 weeks. The study demonstrates that centrocentral anastomosis reduces the size of the neuroma formation and the incidence of autotomy.
D000818:Animals; D008297:Male; D009463:Neuroma / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D010146:Pain / Q000601:surgery; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000601:surgery; D013979:Tibial Nerve / Q000601:surgery