The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma.
The bronchodilator effect of a 10 mg/kg dose of theobromine (3,7-dimethylxanthine) was compared with that of 5 mg/kg of theophylline (1,3-dimethylxanthine) in young patients with asthma. Bronchodilation, as assessed by forced vital capacity, forced expiratory volume in the first second, forced expiratory flows at 25%, 50%, and 75% of vital capacity, and percent of forced expiratory volume in the first second/forced vital capacity did not differ significantly between the two drugs. After each drug bronchodilation peaked at 2 hours and lasted for 6 hours, although it was not always statistically significant for theobromine. The mean peak serum concentrations of both drugs, the time at which peak serum concentrations occurred, and elimination half-life values were similar for theobromine and theophylline.
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007700:Kinetics; D008297:Male; D013805:Theobromine / Q000378:metabolism / Q000627:therapeutic use*; D013806:Theophylline / Q000627:therapeutic use; D013997:Time Factors
D013806:Theophylline; D013805:Theobromine