Naloxone interaction with some CNS depressants.
Mice were either pretreated with naloxone (10 mg/kg i.p.) and then injected with a hypnotic, or given a similar dose of naloxone simultaneously with a hypnotic (combination treatment). Neither the naloxone pretreatment nor the combination treatment changed the time of on-set or the sleeping duration of urethane, chloral hydrate or ketamine. However, the naloxone pretreatment markedly decreased the on-set time and prolonged the sleeping duration of phenobarbitone and barbitone; naloxone in combination prolonged the sleeping duration of pentobarbitone, phenobarbitone and barbitone.
D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009270:Naloxone / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D002492:Central Nervous System Depressants; D009270:Naloxone; D010634:Phenobarbital