Determination of plasma tranexamic acid using cation-exchange high-performance liquid chromatography with fluorescence detection.
A procedure is described for the determination of plasma tranexamic acid concentrations using cation exchange high-performance liquid chromatography with fluorescence detection following post-column derivatisation with omicron-phthalaldehyde. The chromatographic conditions were optimised with respect to detector performance and the method applied to measuring the plasma tranexamic acid levels of patients in a double-blind trial.
D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003509:Cyclohexanecarboxylic Acids / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013345:Subarachnoid Hemorrhage / Q000097:blood; D014148:Tranexamic Acid / Q000097:blood*; D009764:o-Phthalaldehyde
D003509:Cyclohexanecarboxylic Acids; D009764:o-Phthalaldehyde; D014148:Tranexamic Acid