Rapid induction of extrapyramidal side effects with combined use of lithium and neuroleptics.
Various forms of toxicity have been described when lithium and neuroleptics are used in combination. Two cases are presented in which extrapyramidal symptoms appeared soon after lithium was added to a regimen of neuroleptics. Clinical variables and pathophysiologic mechanisms are discussed. This reaction warrants further investigation.
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D005260:Female; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D008297:Male
D008094:Lithium; D006220:Haloperidol; D002746:Chlorpromazine