title: [Neurochemical mechanisms of artifical hypobiosis and chemical thermoregulation].
abstract: Artificial hypobiosis in rats and rabbits was modelled using ornid which caused the blockade of neurotransmitter release from adrenergic neurons. The data obtained corroborated the hypothesis of the mechanisms of chemical thermoregulation as well as new ways of controlling these processes up to their complete blockade by means of decreasing adrenergic effects in the organism. Warm-blooded animals were transferred into poikilothermic state and then into hypobiosis under any given body temperature. At 18-20 degrees C, metabolism may be decreased to 1/10 of standard values and the state of hypobiosis may be maintained for a prolonged period remaining eversible without application of any drugs activating or blocking physiological functions.
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D001949:Bretylium Compounds / Q000494:pharmacology*; D001950:Bretylium Tosylate / Q000494:pharmacology*; D004576:Electromyography; D006605:Hibernation; D007036:Hypothermia, Induced; D008954:Models, Biological; D009132:Muscles / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*; D013565:Sympatholytics / Q000494:pharmacology*
chemical_list: D001949:Bretylium Compounds; D013565:Sympatholytics; D001950:Bretylium Tosylate
vernacular_title: Neirokhimicheskie mekhanizmy iskusstvennogo gipobioza i khimicheskoĭ termoreguliatsii.