Combined trisomy 1q and monosomy 7q due to translocation 1;7 in myelodysplastic syndromes.
Two patients, possibly exposed to toxic agents, presented with a myelodysplastic syndrome (MDS) and a t(1;7) in bone marrow metaphases. This observation confirms the occurrence of this characteristic chromosome anomaly in MDS and its possible induction by environmental agents. It is hypothesized that this t(1;7) MDS may not be confined to a particular geographical area but that, in the past, it may have been overlooked in the absence of optimal banding, which is obviously necessary to identify the anomaly.
D000328:Adult; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy