Studies on the purification and characteristics of histidine-rich glycoprotein.
HRG demonstrated a high affinity for heparin and could thus participate in the inhibition of the clotting mechanism. HRG had inhibitory effects on DS as well, as was observed from assaying HC II activity. This investigation will be continued to clarify the role of HRG, HC II, AT III, and heparin in the prevention of thrombi formation.
D002118:Calcium / Q000494:pharmacology; D002852:Chromatography, Ion Exchange; D003871:Dermatan Sulfate / Q000494:pharmacology; D006023:Glycoproteins / Q000302:isolation & purification*; D006493:Heparin / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D011506:Proteins / Q000302:isolation & purification* / Q000378:metabolism; D000099053:Histidine-Rich Glycoprotein
D006023:Glycoproteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; D003871:Dermatan Sulfate; D006493:Heparin; D002118:Calcium