Evaluation of skin carcinogenicity of technical 2,2-bis-(p-glycidyloxyphenyl)-propane in CF1 mice.
The carcinogenic potential of a technical-grade epoxy resin, Araldite GY 250, of which the diglycidyl ether of bisphenol A (DGEBPA) is the main component, was investigated in CF1 mice. Groups of 50 male and 50 female mice were treated for 2 yr by repeated epidermal application of a 1 or 10% (v/v) solution in acetone. The controls, 50 mice of each sex, were treated with acetone alone. The treatment had no effect on survival and no excess incidence of skin tumours occurred. A positive control group of 50 male and 50 female CF1 mice was treated by epidermal application of 2% (v/v) beta-propiolactone in acetone. In this group there was a high incidence of malignant skin tumours at the site of application and, consequently, increased mortality. Treatment with neither DGEBPA technical nor beta-propiolactone induced systemic neoplasia.
D000096:Acetone / Q000008:administration & dosage / Q000633:toxicity; D000287:Administration, Topical; D000818:Animals; D001559:Benzhydryl Compounds; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens; D004852:Epoxy Compounds / Q000008:administration & dosage / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D011420:Propiolactone / Q000008:administration & dosage / Q000633:toxicity; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology; D000098826:Bisphenol A Compounds
D000096:Acetone; D001559:Benzhydryl Compounds; D002273:Carcinogens; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D011420:Propiolactone; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds