[Sarcolysine sensitivity of the progeny of the clonogenic cells of rat rhabdomyosarcoma RA-2].
Cells of rat rhabdomyosarcoma Ra-2 inoculated intravenously were trapped only in lungs and formed progressively growing monoclonal metastases. The population of clones was sensitive to the sarcolysin treatment (10-30 mg/kg) at all stages of clone formations (from 1 to 14 days). The drug acted by two ways: by the reduction of the number of clones and by the clone growth rate inhibition. Independent variability of both types of the clone sensitivity resulted in the highly heterogeneous response of clone populations to the sarcolysin treatment.
D000818:Animals; D002999:Clone Cells / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D012208:Rhabdomyosarcoma / Q000188:drug therapy*; D013997:Time Factors
D008558:Melphalan
Chuvstvitel'nost' k sarkolizinu potomstva klonogennykh kletok rabdomiosarkomy RA-2 krys.