A mathematical analysis of the influence of aging on enzyme deactivation kinetics.
A series-type enzyme deactivation model is utilized to examine and to quantify the influence of aging on the deactivation kinetics of various enzymes. The effect of in vivo aging as well as the influence of "dwell time" on the deactivation kinetics of enzymes from organisms and cells of different age is examined. The influence of chemical modifiers on the deactivation kinetics of enzymes from cells of different age is elucidated. Attempts have been made to suggest and provide reasonable explanations for the structure-function relations for aging-influenced enzymes.
D000375:Aging; D000818:Animals; D002478:Cells, Cultured; D004798:Enzymes / Q000378:metabolism*; D004905:Erythrocyte Aging; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000254:growth & development; D007700:Kinetics; D008433:Mathematics; D008871:Microvilli / Q000201:enzymology; D008954:Models, Biological; D010735:Phosphoglycerate Kinase / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011817:Rabbits
D004798:Enzymes; D005954:Glucosephosphate Dehydrogenase; D010735:Phosphoglycerate Kinase; D010751:Phosphopyruvate Hydratase