Transplacental micronucleus inducing ability of arecoline, a betel nut alkaloid, in mice.
Arecoline, a major betel nut alkaloid, was tested for its effectiveness in inducing micronuclei in fetal mouse blood after transplacental exposure late in the gestation period. Positive results were obtained and a linear dose-response relationship was expressed when pregnant mice were treated with arecoline at dose levels of 20, 40 and 80 mg/kg and micronucleated polychromatic erythrocytes from fetal blood were subsequently analysed.
D000818:Animals; D001115:Arecoline / Q000378:metabolism / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy
D001115:Arecoline