[Interaction of morphine and non-steroid anti-inflammatory agents].
A study was made of the analgesic action of combined morphine and nonsteroidal anti-inflammatory agents (NAIA)--voltaren, ibuprophen and metindol. It was established that injection of morphine prior to NAIA gives rise to a reduction in the analgesic effect, whereas the combined use of the drugs or administration of NAIA following morphine entails the retention of the effect. Pretreatment with prostaglandin E produces opposite changes in the effect of the analgesics--potentiation of analgesia upon morphine injection and its reduction after NAIA. The data obtained present indirect evidence for the importance of prostaglandins in the antagonism of morphine and NAIA.
D000698:Analgesia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004347:Drug Interactions; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D011459:Prostaglandins E, Synthetic; D004008:Diclofenac; D009020:Morphine; D007052:Ibuprofen; D007213:Indomethacin
Vzaimodeĭstvie morfina i nesteroidnykh protivovospalitel'nykh sredstv.