Kindling phenomenon of hyperthermic seizures in the epilepsy-prone versus the epilepsy-resistant rat.
A kindling-like effect was produced by exposing 30-day-old rats to repeated hyperthermia-induced seizures. Naive audiogenic seizure (AGS)-susceptible rats (P77PMC) were easier to be kindled than AGS-resistant rats (Wistar). This hyperthermic kindling model may be used to study the outcome and mechanisms of human febrile seizures. The mechanisms underlying hyperthermic kindling remain to be investigated.
D000161:Acoustic Stimulation; D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004827:Epilepsy / Q000235:genetics; D006801:Humans; D006979:Hyperthermia, Induced; D007696:Kindling, Neurologic; D051381:Rats; D011930:Reaction Time / Q000502:physiology; D003294:Seizures, Febrile / Q000503:physiopathology*