Effect of certain additives on the diffusion characteristics through a cellophane membrane of acetylsalicylic acid, salicylamide and phenacetin. Part 1: Effect of certain surface active agents.
The diffusion rate (D. R.) of certain ionic and non-ionic surfactant concentrations through a standard cellophane membrane was studied. D. R. of acetylsalicylic acid significantly increased in the presence of 0.1% w/v Brij 35, Tween 20 or 40 respectively. The other tested surfactants slightly increased D. R. of acetylsalicylic acid, while that of salicylamide increased in presence of 0.1% w/v of either Tween 20, 40, 60 or 80; Myrj 52 or 59; Brij 58; benzalkonium chloride, cetrimide or sodium lauryl sulphate. The highest D. R. of phenacetin was observed in presence of either 0.01% w/v Tween 20 or 0.001% w/v Brij 35.
D000700:Analgesics / Q000032:analysis*; D001241:Aspirin / Q000032:analysis; D002476:Cellophane; D002626:Chemistry, Pharmaceutical; D004058:Diffusion; D005079:Excipients; D007700:Kinetics; D008567:Membranes, Artificial; D010615:Phenacetin / Q000032:analysis; D012457:Salicylamides / Q000032:analysis; D013501:Surface-Active Agents / Q000494:pharmacology*
D000700:Analgesics; D005079:Excipients; D008567:Membranes, Artificial; D012457:Salicylamides; D013501:Surface-Active Agents; D002476:Cellophane; C031060:salicylamide; D010615:Phenacetin; D001241:Aspirin