Stimulation of differentiation in human melanoma cells by dimethyl sulphoxide (DMSO).
Stimulation of differentiation in human amelanotic melanoma cell line by 0.5, 1, 1.5 and 2% DMSO expressed in increased melanization was linked to significant decrease in proliferation rate of these cells. After removing DMSO the 0.5 and 1% samples became within 14 days again amelanotic with the same growth capacity as untreated controls. The 1.5 and 2% samples did not recover after DMSO removing and the inhibition of proliferation was irreversible.
D002453:Cell Cycle / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D008543:Melanins / Q000096:biosynthesis; D008545:Melanoma / Q000473:pathology*
D008543:Melanins; D004121:Dimethyl Sulfoxide