[Baygon (2-isopropoxyphenyl-N-methyl carbamate) activation of enzymatic deamination of 2-phenyl-ethylamine].
Carbamate-containing pesticides, particularly baygon, might alter the activity of monoamine oxidase (MAO) in vivo. Baygon was found to stimulate selectively the deamination of 2-phenylethylamine, which is a specific substrate of MAO of the B type; the stimulating effect of baygon was reversible. Kinetic studies showed that the stimulation of the enzyme in presence of baygon of the competitive type. A selective inhibitor of MAO of the B type deprenyl might prevent the impairments of the central nervous system, which are observed in the baygon intoxication. Estimation of the MAO activity in blood thrombocytes may be used as a new biochemical test in diagnosis of intoxications caused by pesticides.
D000818:Animals; D001921:Brain / Q000201:enzymology; D003641:Deamination; D004789:Enzyme Activation / Q000187:drug effects; D007425:Intracellular Membranes / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010627:Phenethylamines / Q000378:metabolism*; D001074:Propoxur / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013379:Substrate Specificity; D014439:Tyramine / Q000378:metabolism
D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; C029261:phenethylamine; D012701:Serotonin; D001074:Propoxur; D008995:Monoamine Oxidase; D014439:Tyramine
Ob aktivatsii baĭgonom (2-izopropoksifenil-N-metil karbamat) fermentativnogo dezaminirovaniia 2-fenil-étilamina.