Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters.
The uptake of 123I-5-iodo-2-thiouracil in melanotic and amelanotic melanoma implanted in Syrian golden hamsters was studied. A selective accumulation was found in the tumours. Uptake of 123ITU in melanotic melanomas was 4 to 5 times the uptake in amelanotic ones. For both tumours high ratios of tumours versus non-tumour were found. The high accumulation of 123ITU in both kinds of tumours and the high tumour versus non-tumour ratios suggest that 123ITU may be a promising radiopharmaceutical for the detection of ocular melanoma.
D000818:Animals; D006224:Cricetinae; D005134:Eye Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008647:Mesocricetus; D011877:Radionuclide Imaging; D013889:Thiouracil / Q000031:analogs & derivatives* / Q000378:metabolism
D007457:Iodine Radioisotopes; D013889:Thiouracil; C036667:iodothiouracil