Influence of chlorpromazine on the accumulation of 5-hydroxytryptamine by interaction with ATP.
5-Hydroxytryptamine accumulates at pH 6.0 when ATP is present on one side of an artificial lipoidal barrier. In the presence of chlorpromazine, the diffusion of ATP through the barrier and a decrease in the accumulation of serotonin can be noted. The diffusion rate constants of ATP and serotonin are related to the concentration of chlorpromazine.
D000255:Adenosine Triphosphate / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002746:Chlorpromazine / Q000032:analysis*; D004058:Diffusion; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D000255:Adenosine Triphosphate; D002746:Chlorpromazine