Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates.
This study has shown that: both inhaled (2 mumol/kg) and injected (30 mumol/kg) diethylenetriaminepenta-acetic acid (DTPA) can reduce the lung deposit of 238 Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls; injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238Pu and 241Am in the liver and skeleton; combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.
D000336:Aerosols; D000576:Americium / Q000378:metabolism*; D000818:Animals; D006224:Cricetinae; D005260:Female; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D008647:Mesocricetus; D009566:Nitrates; D004369:Pentetic Acid / Q000494:pharmacology*; D011005:Plutonium / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
D000336:Aerosols; D009566:Nitrates; C015459:plutonium nitrate; C041805:americium nitrate; D011005:Plutonium; D004369:Pentetic Acid; D000576:Americium