Antigenic and morphological similarities of progressive pneumonia virus, a recently isolated "slow virus" of sheep, to visna and maedi viruses.
Progressive pneumonia virus, the causative agent of a slow, pulmonary disease of Montana sheep, was shown to be antigenically related to two other slow viruses of sheep, visna and maedi. Electron microscopic examination of infected cells revealed that the virus matures by a budding process and that the budding particles as well as the mature, extracellular virions bear striking resemblances to the oncogenic ribonucleic acid (RNA) viruses. Recent findings of an RNA-dependent deoxyribonucleic acid polymerase associated with the virions of this group of slow viruses lend further support to the notion that they may tentatively be classified with the oncogenic RNA tumor viruses.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D008297:Male; D009858:Oncogenic Viruses / Q000145:classification; D011024:Pneumonia, Viral / Q000382:microbiology*; D011328:Prions / Q000276:immunology; D011648:Pulmonary Adenomatosis, Ovine / Q000382:microbiology*; D012328:RNA Viruses / Q000145:classification; D011817:Rabbits; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology*; D012897:Slow Virus Diseases / Q000382:microbiology; D013045:Species Specificity; D014779:Virus Replication; D014713:Viruses, Unclassified / Q000145:classification / Q000254:growth & development / Q000276:immunology; D005719:gamma-Globulins
D000941:Antigens; D007106:Immune Sera; D011328:Prions; D005719:gamma-Globulins