The development of tolerance to the depressant effect of arginine-8 vasopressin on the spontaneous motor activity of rats.
Arginine-8 vasopressin (1.0 IU/kg, s.c.) reduced the spontaneous motor activity of rats with no previous experience of the drug. Daily administration of arginine vasopressin (1.0 IU/kg, s.c., once daily) to rats resulted in the gradual development of tolerance to the depressant effect of the drug on spontaneous activity. In further experiments, rats with no previous experience of the activity box, but chronically treated with arginine vasopressin (1.0 IU/kg, s.c., 3 times daily), also displayed tolerance to the depressant effect of the drug. The development of tolerance was therefore dependent on repeated exposure to vasopressin and not on repeated experience of the activity box.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003864:Depression, Chemical; D004361:Drug Tolerance; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001127:Arginine Vasopressin