Evaluation of portal circulation in rats by rectal administration of 201Tl followed by intrasplenic injection of 51Cr-labeled microspheres.
The heart-to-liver (H/L) uptake ratio in rats was determined 8 min after the rectal administration of 201Tl. Apart from normal controls, three groups of rats were examined; these were composed of animals with induced (1) acute hepatic damage, (2) liver cirrhosis, and (3) partial portal-vein ligation. After the rectal administration of 201Tl, 51Cr-labeled microspheres were injected into the spleen. The radioactivity of the removed liver, lungs, and heart was determined in a gamma-well scintillation counter, and the radioactivity of 201Tl and the 51Cr-labeled microspheres was separately calculated using simultaneous equations derived from the results of a preliminary experiment. The H/L ratios (201Tl) in the normal controls and the animals with acute hepatic damage were not significantly different; however, there was a positive correlation (P less than 0.01) between the H/L ratio and the shunt index (51Cr microspheres) in three groups, i.e., normal controls, liver cirrhosis, and partial portal-vein ligation.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000000981:diagnostic imaging; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging; D002860:Chromium Radioisotopes; D006321:Heart / Q000000981:diagnostic imaging; D006975:Hypertension, Portal / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D008106:Liver Cirrhosis, Experimental / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008863:Microspheres; D011168:Portal System / Q000000981:diagnostic imaging*; D011868:Radioisotopes / Q000008:administration & dosage; D011877:Radionuclide Imaging; D051381:Rats; D012007:Rectum; D013793:Thallium / Q000008:administration & dosage
D002860:Chromium Radioisotopes; D011868:Radioisotopes; D013793:Thallium