Comparison of the concentration-effect relationship of a local antiinflammatory agent and oral acetylsalicylic acid: the value of local application.
Using a pharmacological model, the comparison between acetylsalicylic acid (ASA), administered orally, and a solution combining two salicylate derivatives (ethyl 5-methoxy-salicylate and 3-phenyl-propyl-salicylate), applied locally, demonstrated the value of the local application. Indeed, the pharmacological activity was highly significant and directly related to the tissue concentration of salicyl ions, which was higher after local application of the solution than after oral administration of ASA. The local solution also resulted in a lower plasma concentration of salicylate ions, allowing high plasma salicylate concentrations to be avoided.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000517:prevention & control; D007509:Irritants / Q000037:antagonists & inhibitors; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D007509:Irritants; D001241:Aspirin