Changes in mineral content and biochemical bone markers at the menopause.
Serum alkaline phosphatase activity, serum bone gamma-carboxyglutamic acid protein, urinary hydroxyproline and bone mineral content were simultaneously measured in 30 age-matched pre- and postmenopausal women in order to define the temporal relationship between skeletal turnover and bone loss. In postmenopausal women, mean values of phosphatase activity, serum bone gamma-carboxyglutamic acid protein and urinary hydroxyproline were significantly higher, and mean values of mineral content were significantly lower than in premenopausal women. A marked loss of bone mineral content together with a persistent increase in skeletal turnover is already evident shortly after the menopause.
D015055:1-Carboxyglutamic Acid / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D001842:Bone and Bones / Q000032:analysis*; D003404:Creatinine / Q000032:analysis; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D008593:Menopause; D008875:Middle Aged; D008903:Minerals / Q000032:analysis*
D008903:Minerals; D015055:1-Carboxyglutamic Acid; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline