Incomplete androgen insensitivity: asymmetry in morphology and steroid profile and metabolism of the gonads. An analysis of a case.
A patient with clinical manifestations of the incomplete androgen insensitivity syndrome was studied with respect to peripheral blood levels of steroids and steroid sulphates before, during and after gonadectomy. Steroid and steroid sulphate concentrations were also analyzed in spermatic venous blood and gonadal tissue collected during surgery. The metabolic capacity of gonadal tissue was also studied in vitro using progesterone, dehydroepiandrosterone sulphate and oestrone sulphate as substrates. Profound differences between the two gonads were noted with respect to both steroid content and release into pampiniform veins and to in vitro conversion of progesterone and oestrone sulphate. Histological examination revealed the presence of seminiferous tubules with carcinoma in situ in both gonads. It is suggested that the differences between the gonads may be due to an autonomous steroid production in the right gonad in spite of adequate or even elevated gonadotrophic stimulation resulting in a steroidogenic situation resembling the complete androgen insensitivity syndrome, while the conditions found in the left gonad more resembles the incomplete form of the disease.
D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000378:metabolism / Q000473:pathology; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D006066:Gonads / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007985:Leydig Cells / Q000473:pathology; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*; D012671:Seminiferous Tubules / Q000473:pathology
D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D011944:Receptors, Androgen