Subendothelial accumulation of unesterified cholesterol. An early event in atherosclerotic lesion development.
This preliminary report describes the simplest and possibly earliest lipid-containing lesions induced in aortas of rabbits fed a cholesterol-containing diet. Subendothelial accumulation of unesterified cholesterol, detected with filipin dye, appears to precede morphologic changes in endothelium and accumulation of subendothelial lipid-containing "foam" cells. The origin of subendothelial unesterified cholesterol remains to be determined.
D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D005487:Foam Cells / Q000378:metabolism / Q000473:pathology; D008297:Male; D011817:Rabbits; D013997:Time Factors
D002784:Cholesterol