Pharmacokinetic model to describe the disposition of lead in the rat.
A pharmacokinetic model was developed to describe the disposition of lead in the rat. The model can be used to predict the effect of acute high-dose as well as low-dose exposure to lead. These results suggest that the model should be able to predict the effect of chronic low-dose exposures as well. Plasma, bone, liver, and bile profiles were generated from this model using previously published data. The results obtained supported the existing theory that lead demonstrates a dose-dependent pharmacokinetic profile in the rat.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D007854:Lead / Q000378:metabolism*; D007855:Lead Poisoning / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D051381:Rats
D007854:Lead