[Porphyrin biosynthesis in patients with acute and chronic kidney failure treated by hemodialysis].
Biosynthesis of porphyrin in erythrocytes was studied in 48 patients, 23 of them being with acute renal insufficiency (ARI) and 25--with terminal chronic renal insufficiency (CRI), after incubation of delta-aminolevulinic acid (synthesized uro- copro- and protoporphyrin), synthesized porphobilinogen, the activity of porphobilinogen-synthesis, erythropoietic activity of serum and hematological indices. The biosynthesis of porphyrins in both groups of patients was established to be reduced, more strongly in those with CRI that could serve as one of the criteria in the differentiation of ARI from CRI. After the discontinuation of the treatment, the biosynthesis of porphyrins in the patients with ARI approached that of the clinically healthy subjects. In the patients with CRI, included in the programmed hemodialysis treatment, the biosynthesis of porphyrins was intensified and that of synthesized protoporphyrins--considerably reduced.
D058186:Acute Kidney Injury / Q000378:metabolism* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011162:Porphobilinogen / Q000096:biosynthesis; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011166:Porphyrins / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D006435:Renal Dialysis
D011166:Porphyrins; D011162:Porphobilinogen; D000623:Porphobilinogen Synthase
Biosinteza na porfirini pri bolni s ostra i khronichna bŭbrechna nedostatŭchnost, lekuvani s khemodializa.