Antifertility effect of polyvinylpyrrolidone-gossypol and gossypol in male rats.
Thirty-nine adult male Wistar rats were administered 20 mg/kg or 24.3 mg/kg polyvinylpyrrolidone-gossypol (PVP-G) and 20 mg/kg gossypol acetic acid (G-A) 6 times a week for 6 weeks. Mating test was taken to evaluate the antifertility effect. Caudal sperm count, body weight, sex and accessory sex organ weights were recorded. At the end of 6 weeks treatment, the recovery period of 6 weeks was investigated. The results showed that the onset of antifertility action and recovery with PVP-G are faster than with G-A.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000494:pharmacology*; D008297:Male; D011205:Povidone / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013076:Sperm Count / Q000187:drug effects; D013737:Testis / Q000166:cytology / Q000187:drug effects; D013997:Time Factors
D011205:Povidone; D006072:Gossypol