The distribution of orally administered 14C-aniline HCl in tissues of dairy cattle, swine and laying pullets.
Single or chronic daily (30 d) doses of 14C-aniline (an aromatic amine) were administered to dairy cattle, swine and laying pullets to determine the amount of an ingested synfuel-related chemical that would remain in consumable animal products. The 14C-residues were found in muscle, liver, other edible organs and fat, as well as in milk and eggs. The predominant site of deposition in acute- and chronic-exposed pullets was kidney, followed by internal yolk (immature ovum of ovary) and then liver. Egg yolk was the major site of 14C-radioactivity in whole eggs. Liver, then kidney, were the major sites of deposition in acutely exposed swine; when chronically exposed, only liver showed preferential deposition with other tissues surveyed yielding similar concentration values. Dairy cattle yielded tissue distribution patterns similar to chronic swine. Within 8 h after an acute exposure, 14C-residue was detected in milk which reached its maximum at 24 to 32 h. Our data demonstrate that derived concentration values of 14C-residue in tissues was dependent upon the species studied as well as on the mode of exposure, acute versus chronic. Although the concentration values were variable, sufficient amounts of 14C-aniline and (or) its metabolites were found in consumable products.
D000814:Aniline Compounds / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D002645:Chickens / Q000378:metabolism*; D008460:Meat / Q000032:analysis; D013552:Swine / Q000378:metabolism*; D014018:Tissue Distribution
D000814:Aniline Compounds; C023650:aniline