title: The effect of D-penicillamine in different experimental gastric ulcer models in the rat.
abstract: Several sulfhydryl substances were found to protect the gastric mucosa against the ulcerogenic effect of indomethacin, while being ulcerogenic in stress (restraint) ulcer. D-penicillamine showed a dose dependent antiulcerogenic effect in both gastric ulcer models. This experimental result has called attention to the two methyl groups in which the D-penicillamine molecule was different from D-cysteine. It seemed therefore that in contrast to cysteine the favourable effect of D-penicillamine in stress ulcer, was due to this structural difference.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007213:Indomethacin; D010396:Penicillamine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013312:Stress, Physiological / Q000150:complications; D013329:Structure-Activity Relationship
chemical_list: D010396:Penicillamine; D007213:Indomethacin