Hepatocytes in primary culture become susceptible to paracetamol injury after depletion of glutathione using DL-buthionine-SR-sulphoximine (BSO).
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D019328:Buthionine Sulfoximine; D002478:Cells, Cultured; D005978:Glutathione / Q000032:analysis*; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D008717:Methionine Sulfoximine; D000082:Acetaminophen; D019328:Buthionine Sulfoximine; D005978:Glutathione