title: The PDGF-inducible 'competence genes': intracellular mediators of the mitogenic response.
abstract: We have described a new gene family within mammalian cells. Transcription of this gene family is coordinately induced when BALB/c-3T3 cells are exposed to platelet-derived growth factor. At least two cellular proto-oncogenes (c-myc and c-fos) are members of this gene family, which we term 'competence'. At least one competence gene, c-myc, functions as an intracellular mediator of the mitogenic response to PDGF. Expression of the competence gene family may be a central component of the mitogenic response in fibroblasts, lymphocytes and regenerating liver.
mesh_terms: D000818:Animals; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011519:Proto-Oncogenes; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D010982:Platelet-Derived Growth Factor; D004247:DNA; D013755:Tetradecanoylphorbol Acetate