Methylmethacrylate blood levels in patients with femoral neck fracture.
The blood levels of monomeric methylmethacrylate were measured in 20 patients with fracture of the femoral neck, treated with a Thompson prosthesis under spinal anesthesia. Monomeric methylmethacrylate was detected in the blood stream in all patients; the maximum levels (mean 6.44 micrograms/ml, range 0.05-31.89 micrograms/ml) were measured 30 s after insertion of the Thompson prosthesis. A moderate drop in systolic blood pressure and a marked reduction of arterial oxygen tension was noted after cementation and insertion of the prosthesis; the mean maximum drops were 10.1 mm Hg (range 0-32 mm Hg) and 6.1 mm Hg (range 0-13.5 mm Hg) No dose-dependent correlation could be established between the levels of monomeric methylmethacrylate and the drop in arterial blood pressure or arterial oxygen tension.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000009:adverse effects / Q000032:analysis*; D002849:Chromatography, Gas; D005260:Female; D005265:Femoral Neck Fractures / Q000097:blood* / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008768:Methylmethacrylates / Q000009:adverse effects / Q000032:analysis*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
D001843:Bone Cements; D008768:Methylmethacrylates; D010100:Oxygen