Anticomplementary, anticoagulatory, and serum-protein precipitating activity of sodium polyanetholsulfonate.
Sodium polyanetholsulfonate (SPS) at 7.8 mug/ml completely abolished complement-mediated hemolysis of 1:10 diluted fresh guinea pig and human serum; at least twice as much SPS was required to reduce complement activity in 1:2 diluted human serum. The coagulation of 90 and 20% human blood was inhibited by 250 and 125 mug of SPS per ml, respectively. When added to fresh human serum, SPS precipitated beta 1C-globulin (C3), C4, beta lipoproteins, immunoglobulin IgG, IgM, and IgA, though incompletely.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001798:Blood Proteins; D003165:Complement System Proteins; D006041:Goats; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007136:Immunoglobulins; D008074:Lipoproteins / Q000097:blood; D011233:Precipitin Tests; D013451:Sulfonic Acids / Q000494:pharmacology*; D014168:Transferrin; D005719:gamma-Globulins
D001798:Blood Proteins; D007106:Immune Sera; D007136:Immunoglobulins; D008074:Lipoproteins; D013451:Sulfonic Acids; D014168:Transferrin; D005719:gamma-Globulins; D003165:Complement System Proteins