[Inhibition of the synthesis of isoprenoid compounds by phenol precursors of the benzoquinone ring of ubiquinone].
Effects of p-hydroxybenzoic and 3,4-dihydroxybenzoic acids on incorporation of I-14C-acetate into ubiquinone, sterols and nonsaponifiable lipid fraction were studied in liver slices. Inhibition of the label incorporation into all the isoprenoid-containing compounds studied was found, when these phenolic acids were used at I mM and higher concentrations. At the same time, inhibition of the ubiquinone biosynthesis was especially distinct although concentration of the substance was increased in mixtures in presence of phenolic acids as compared with controls.
D000818:Animals; D062385:Hydroxybenzoates / Q000494:pharmacology*; D066298:In Vitro Techniques; D008055:Lipids / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism*; D008297:Male; D010226:Parabens; D011106:Polyisoprenyl Phosphates / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051381:Rats; D013261:Sterols / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D014451:Ubiquinone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D062385:Hydroxybenzoates; D008055:Lipids; D010226:Parabens; D011106:Polyisoprenyl Phosphates; D013261:Sterols; D014451:Ubiquinone; C009091:protocatechuic acid; C038193:4-hydroxybenzoic acid
Tormozhenie sinteza izoprenoidnykh soedineniĭ fenol'nymi predshestvennikami benzokhinonovogo kol'tsa ubikhinona.