title: Determinants of residual effects of hypnotics.
abstract: Studies of hypnotics have generally focused on the effects the drugs have on sleep. It is now clear that they also have effects which can extend beyond the usual sleep period. These residual effects of hypnotics are assessed by studying the effects of these drugs on performance. This paper discusses the issues critical to evaluating studies of the effects of hypnotics on performance. Dose and half-life are important variables in determining the degree to which these daytime effects occur following nighttime use. However, a number of issues have yet to be clarified. Whether residual effects persist with chronic use is not clear. Whether any specific skill may be more or less sensitive to residual effects cannot be determined from the available information. Finally, the degree to which the decrements occur in different populations is not well understood.
mesh_terms: D001569:Benzodiazepines / Q000378:metabolism / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D011597:Psychomotor Performance / Q000187:drug effects; D012107:Research Design; D012890:Sleep
chemical_list: D006993:Hypnotics and Sedatives; D001569:Benzodiazepines