Cortisol suppresses radiation transformation in vitro.
It is reported that 10(-7) M cortisol has a significant suppressive effect on radiation-induced transformation in vitro in C3H10T1/2 cells. Previously reported data showed a significant enhancing effect for similar experiments performed with cortisone. Thus, these two structurally similar glucocorticoid hormones have opposite effects on transformation induced by ionizing radiation.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000528:radiation effects*; D003907:Dexamethasone / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D051379:Mice
D003907:Dexamethasone; D006854:Hydrocortisone