Bioavailability studies of calcium dobesilate--a case of flip-flop kinetics.
Absolute and relative bioavailability of two commercial calcium dobesilate tablets were evaluated in ten healthy volunteers in a cross-over trial using a newly developed HPLC detection method. Both tablet forms were absorbed completely but very slowly thus leading to a flip-flop kinetics. It could be shown that AUC values derived from flip-flop models were comparable with those of normal i. v. kinetics.
D000042:Absorption; D000328:Adult; D001557:Benzenesulfonates / Q000378:metabolism*; D001682:Biological Availability; D002123:Calcium Dobesilate / Q000008:administration & dosage / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D013607:Tablets
D001557:Benzenesulfonates; D013607:Tablets; D002123:Calcium Dobesilate