title: Cortisol does not inhibit prednisolone clearance.
abstract: The disposition of prednisolone has been studied in eight male subjects with and without the concomitant administration of cortisol which produced plasma cortisol concentrations 10-fold higher than endogenous levels. The clearance and steady-state distribution volume of total prednisolone were increased as was the prednisolone free fraction but the clearance of unbound prednisolone was unaltered by cortisol co-administration.
mesh_terms: D000328:Adult; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011239:Prednisolone / Q000378:metabolism*
chemical_list: D011239:Prednisolone; D006854:Hydrocortisone