Opiate antagonists in shock.
In 1978 Holaday and Faden reported that naloxone prevented and reversed endotoxin-induced hypotension in rats. Since then, the potential of endogenous opioid peptides in the treatment of shock has come under scrutiny. This brief review puts the work of the last 8 years in perspective.
D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D012769:Shock / Q000188:drug therapy* / Q000503:physiopathology; D012772:Shock, Septic / Q000188:drug therapy
D009292:Narcotic Antagonists; D009270:Naloxone