[Hypertension in rats caused by metyrapone and heat-stress treatment].
All Wistar rats showed hypertension when they were given heat-stress and administered metyrapone (200 micrograms/kg/day), a cholesterol-11-beta-hydroxylase inhibitor. The addition of saline loading potentiated the hypertensive state. The hypertension in MH-rats was blocked by a low dose (1 mg/kg) of propranolol, a dose which was insufficient to cure the Spontanous Hypertensive rats, and by a very low dose (20 ng/kg) of 1-dopa with carbidopa treatment, but not by haloperidol, sulpiride, or prazosin. Striatal dopamine (DA) of MH-rats was increased significantly. These results suggested that the hypertension of MH-rats was related to the inhibition of central DA release. Since MH-rats showed the availability of propranolol clearly, this may be a useful model for hypertension.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D006358:Hot Temperature / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
D012965:Sodium Chloride; D011433:Propranolol; D004298:Dopamine; D008797:Metyrapone