title: [Reactivity of the blood system in the late periods following administration of the antitumor antibiotic rubomycin].
abstract: The reserve potentialities of granulocyto- and erythropoesis were studied in noninbred rats and BALB/c mice using morphological functional methods and various compensatory-functional simulators of hemopoiesis strain 1.3 and 6 months after treatment with rubomycin at a therapeutic dose of 1.5 mg/kg. The animals were found to retain limited granulocyto- and erythropoesis compensatory reactions to additional hemopoesis-disturbing influences in spite of complete recovery of hematopoetic stem-cell pool, bone marrow and peripheral blood cell composition at remote terms after treatment.
mesh_terms: D000818:Animals; D001769:Blood / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D003630:Daunorubicin / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D013997:Time Factors
chemical_list: D003630:Daunorubicin
vernacular_title: Reaktivnost' sistemy krovi v otdalennye sroki posle vvedeniia protivoopukholevogo antibiotika rubomitsina.