Effect of aluminum chloride on ascending colon of the rat.
Aluminum chloride (2.48 X 10(-4) to 1.24 X 10(-3) M) inhibits spontaneous motility of ascending colon of the rat. Resting tension was not affected. At concentrations between 2.07 X 10(-5) to 1.24 X 10(-3) M it inhibited in a dose-dependent manner the contractions induced by maximal doses of acetylcholine. Higher doses produced a very marked inhibition that was attributable to acidification of the medium. The inhibiting effect was more intense when the incubation medium contained an excess of calcium (3.6 and 4.3 mM) or theobromine (10(-4) and 10(-3) M). This inhibiting effect tended to be smaller in the presence of low calcium (0.6 and 1.0 mM) or verapamil (3 X 10(-8) and 10(-7) M).
D000109:Acetylcholine / Q000494:pharmacology; D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002712:Chlorides; D003106:Colon / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013805:Theobromine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D014700:Verapamil; D000535:Aluminum; D000109:Acetylcholine; D013805:Theobromine