Pantetheine and pantethine esters with hypolipidemic nicotinic acid derivatives.
We prepared several esters of pantetheine and pantethine, respectively, with 3-pyridineacetic acid and with 3-(3-pyridinemethoxycarbonyl)propionic acid, and we tested these products for their capacity to lower serum non-esterified fatty acids and triglycerides in normal animals. Among the products thus tested, the tetraester of pantethine with 3-(3-pyridinemethoxycarbonyl)propionic acid (MG 28362) displayed marked hypolipidemic activity, the action being of uncommonly long duration.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005230:Fatty Acids, Nonesterified / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D009539:Nicotinic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D010204:Pantetheine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013056:Spectrophotometry, Ultraviolet; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; D013438:Sulfhydryl Compounds; D014280:Triglycerides; D010204:Pantetheine; C005425:pantethine