title: Nucleotide sequence of the 5S ribosomal RNA gene repeat of Trypanosoma brucei.
abstract: The 750 base pair tandem repeat specifying the 5S ribosomal RNA of Trypanosoma brucei brucei has been cloned and four independent clones sequenced to completion. The repeat specifies only a single 5S rRNA and is unusually long when compared with other 5S gene repeats. The sequenced copies contain a number of sequence polymorphisms similar to those seen in the ribosomal genes of other organisms. By comparison with the consensus sequence for RNA polymerase III promoters ('internal control regions') a possible 'internal control region' for RNA polymerase III can be located in the predicted position within the 5S ribosomal RNA sequence.
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D009693:Nucleic Acid Hybridization; D011401:Promoter Regions, Genetic; D012320:RNA Polymerase III / Q000032:analysis / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D014346:Trypanosoma brucei brucei / Q000201:enzymology / Q000235:genetics*
chemical_list: D012335:RNA, Ribosomal; D012320:RNA Polymerase III