Synthesis of 5'(3')-O-amino nucleosides.
Synthetic methods leading to 5'(3')-O-amino nucleosides have been developed in an effort to prepare derivatives that may have antitumor or antiviral activities. They are based on ring opening of O2,5'-cyclonucleosides with the N-protected hydroxylamines and dehydrative coupling of 5'(3')-O-unprotected nucleosides with N-hydroxyphthalimide.
D000606:Amino Sugars / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007202:Indicators and Reagents; D009705:Nucleosides / Q000138:chemical synthesis*
D000606:Amino Sugars; D007202:Indicators and Reagents; D009705:Nucleosides