title: Topographical projection of cholinergic neurons in the basal forebrain to the cingulate cortex in the rat.
abstract: The cholinergic innervation of the rat's posterior cingulate cortex (Brodmann's area 29) was studied using acetylcholinesterase (AChE) histochemistry. Electrolytic lesion of the ipsilateral medial septum and diagonal band region (MS-DB) reduced the diffuse AChE staining in layers I, II, III and V of the cingulate cortex. Kainic acid lesion of the ipsilateral globus pallidus and substantia innominata area (GP-SI) abolished the dense band of AChE stain in layer IV, with small reductions of AChE stain in other layers. The results indicate that the medial cholinergic pathway from MS-DB terminates diffusely in layers I, II, III and V while the lateral cholinergic pathway from the GP-SI predominantly ends in layer IV of the posterior cingulate cortex.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001479:Basal Ganglia / Q000033:anatomy & histology*; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002799:Cholinergic Fibers; D006179:Gyrus Cinguli / Q000033:anatomy & histology*; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D051381:Rats; D012688:Septum Pellucidum / Q000033:anatomy & histology*; D013377:Substantia Innominata / Q000033:anatomy & histology*
chemical_list: D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase