The role of cytostasis in antitumor immunity: comparison between syngeneic and allogeneic systems.
Different aspects of the immune response differ with respect to sensitivity of neonatal thymectomy (NTx). The effect of thymectomy on Days 1 and 7 after birth (NTx-1, NTx-7) on antitumor immune responses to both a syngeneic and an allogeneic tumor graft was examined. The tumor used was the same, Meth A fibrosarcoma of BALB/c origin, but the mice inoculated differed. The results show that the immune response to a syngeneic tumor graft is primarily cytostatic rather than cytolytic and is relatively insensitive to neonatal thymectomy, while the response to a large dose of allogeneic tumor cells includes a cytolytic mechanism of high thymus dependence.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D002455:Cell Division; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D006084:Graft Rejection; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013934:Thymectomy; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic