title: Cortical and ventral tegmental systems exert opposing influences on self-stimulation from the prefrontal cortex.
abstract: Intracranial self-stimulation (ICSS) was obtained from 3 areas of anteromedial cortex: the prelimbic area (Brodman's area 32), the anterior cingulate area and the posterior cingulate area. Electrical stimulation in the prelimbic and anterior cingulate areas also produces a behavioral inhibition which is most pronounced at anterior sites (i.e. prelimbic) and declines at increasingly more posterior sites. It was found that the acquisition of responding for ICSS and the magnitude of amphetamine's facilitation of ICSS were inversely related to the degree of behavioral inhibition. These data and the ability of amphetamine to reverse prefrontal stimulation-induced inhibition suggest an important interaction between the prefrontal cortex and the mesolimbic dopamine systems in the control of goal-directed behavior. A model involving cortical suppression of mesolimbic dopamine function is discussed.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004558:Electric Stimulation; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012653:Self Stimulation / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000502:physiology*
chemical_list: D003913:Dextroamphetamine; D004298:Dopamine