Laser injury of peripheral nerve: a model for focal endoneurial damage.
A model of endoneurial oedema is presented which produces localised nerve fibre injury including Wallerian degeneration, endoneurial oedema and increased endoneurial fluid pressure. A carbon dioxide laser was used to irradiate rat sciatic nerve and quantitative results were collected 2 days and 6 days after irradiation. The increase in endoneurial fluid pressure is compared with other models of Wallerian degeneration in which the entire fascicle was involved to aid in a comparative study of the role of oedema in neuropathy.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D004487:Edema / Q000473:pathology; D007834:Lasers / Q000009:adverse effects*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure; D009410:Nerve Degeneration; D009412:Nerve Fibers / Q000648:ultrastructure; D059348:Peripheral Nerve Injuries; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000293:injuries / Q000473:pathology; D014855:Wallerian Degeneration