[The effect of adrafinil on the nocturnal activity of the rhesus monkey (Macaca mulatta)].
The nocturnal activity of a primate was used as an evaluation criterium for a stimulating substance: adrafinil (CRL 40028). Ten rhesus monkeys were placed in a controlled environment and their activity was measured, in relative time, using an ultra-sound system. The animals repeatedly received 60, 90 and 120 mg X kg-1 adrafinil per os. Globally, the dose of 60 mg X kg-1 doubled the animals' nocturnal activity whereas 90 and 120 mg X kg-1 increased it fourfold, the activity level becoming practically identical to diurnal activity. The effects of 60 mg X kg-1 were only significant after the second treatment whereas doses of 90 and 120 mg X kg-1 were already significantly efficient after the first administration. A stimulating effect persisted approximately 36 hrs after the second treatment with 90 or 120 mg X kg-1. No sedative effect of recovery was observed during the posttreatment phase.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D013268:Stimulation, Chemical; D013696:Temperature
D006877:Hydroxamic Acids; C022116:adrafinil
Effets de l'adrafinil sur l'activité nocturne du macaque rhésus (Macaca mulatta).