title: Synthesis and antimicrobial activity of some new isonicotinoylamino acid and dipeptide derivatives.
abstract: The synthesis of a series of isonicotinoylamino acids (II-XI) and some of their corresponding methyl esters (XII-XVIII), hydrazides (XXI-XXVI), dipeptide methyl esters (XXVII-XLII), the di- and tri-glycine peptides (XIX-XX) is described. Sixteen of various isonicotinoylamino acid and dipeptide derivatives were found to possess specific antimicrobial activities towards different microorganisms.
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides; D007539:Isonicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D004151:Dipeptides; D007539:Isonicotinic Acids