[Effect of desaminoocta-pancreozymin on the locomotor activity of rats].
The influence of desaminoocta-pancreozymin (DAO-PZ) was investigated in high and low activity periods by intraperitoneal or intranasal application. DAO-PZ is a CCK-8 derivative in which the N-terminal amino acid (Asp) is exchanged for succinyl acid. A decreasing long lasting effect for 3 to 4 h was always observed in locomotor activity. A food reduction was also proved after i. p. and intranasal application. The effects correspond to those of CCK-8 reported in the literature. They are discussed in this respect.
D000818:Animals; D004435:Eating / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D010446:Peptide Fragments; C025997:cholecystokinin (27-33); D012844:Sincalide
Wirkung von Desaminoocta-Pankreozymin auf die lokomotorische Aktivität von Ratten.