[Effect of blood transfusion on erythropoiesis of homozygotic beta-thalassemia patients].
The influence of blood transfusion on erythropoiesis (bone marrow erythroblasts, peripheral blood erythroblasts and reticulocytes) has been studied in 20 non splenectomized homozygous beta thalassaemia patients aged 3 to 16 years and in 10 splenectomized patients aged 8 to 24 years affected with the same disease. The number of reticulocytes was the same in the two groups but the number of erythroblasts in the splenectomized group was higher than in the other group. There was no correlation between the erythroblasts and the reticulocytes of the peripheral blood on one hand and the haemoglobin level proceeding from the same sample on the other hand. In the non splenectomized group of patients, an inverse relationship was found between the percentage of bone marrow erythroblasts and the mean annual haemoglobin level (r = -0.71; p less than 0.01). These results demonstrate the effect of blood transfusion on the erythroid cell line in homozygous beta thalassaemia and the delay between the transfusions and the medullary erythroblastic response.
D000293:Adolescent; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004900:Erythroblasts / Q000166:cytology; D004906:Erythrocyte Count; D004920:Erythropoiesis; D006454:Hemoglobins / Q000032:analysis; D006720:Homozygote; D006801:Humans; D012156:Reticulocytes / Q000166:cytology; D013789:Thalassemia / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy
D006454:Hemoglobins
Influence de la transfusion sanguine sur l'erythropoïèse des patients bêta thalassémiques homozygotes.