title: Inhibition of an IUD-induced precocious luteolysis by prostaglandin E1 (PGE1) in sheep.
abstract: Fifteen ewes were assigned as they came into estrus to one of three randomized treatment groups: 1. Sham IUD + Vehicle, 2. IUD + Vehicle or 3. IUD + PGE1 in vehicle. An IUD was inserted adjacent to the luteal-bearing ovary on day 3 postestrus. Prostaglandin E1 (500 micrograms) in vehicle (Na2CO3) or vehicle was given intrauterine through an indwelling uterine cannula every four hours from day 3 postestrus until ewes returned to estrus. Precocious estrus was induced in both the sham IUD and IUD groups receiving vehicle. Prostaglandin E1 prevented an IUD-induced premature luteolysis based on daily concentrations of progesterone in peripheral blood and the interestrous interval. It is concluded that an IUD-induced premature luteolysis is not necessarily via physical distention by the IUD. It is also concluded that chronic intrauterine infusions of PGE1 can prevent an IUD-induced premature luteolysis.
mesh_terms: D000527:Alprostadil / Q000494:pharmacology*; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D007434:Intrauterine Devices / Q000009:adverse effects*; D011374:Progesterone / Q000097:blood; D012756:Sheep
chemical_list: D011374:Progesterone; D000527:Alprostadil