Comparison of two calcium antagonists, verapamil and gallopamil (D-600), in exercise-induced asthma.
The effect of inhaled verapamil and gallopamil (estimated dose 3 mg) was studied in 10 patients with exercise-induced asthma. Saline was used as a control. Verapamil and gallopamil modified exercise-induced asthma in 8 of the 10 patients and the degree of inhibition with both the drugs was comparable. Gallopamil, which is a more potent vascular smooth muscle calcium antagonist when compared to verapamil, failed to show a greater protective effect in exercise-induced asthma in the patients studied.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002794:Choline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D005541:Forced Expiratory Volume; D006801:Humans; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D012007:Rectum; D013147:Spirometry; D013806:Theophylline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D014797:Vital Capacity
C012839:cholinophyllin; D013806:Theophylline; D002794:Choline