title: Lack of correlation between plasmid-encoded outer membrane proteins and virulence of Yersinia enterocolitica.
abstract: When various strains of Yersinia enterocolitica belonging to serovars 0:1,3, 0:3, 0:5,27, 0:9 and 0:Tacoma harbouring 44- to 47-Md plasmids, or their spontaneously cured isogenic pairs, were inoculated (i. v., with standardized inocula) into Swiss female mice, the kinetics of bacterial survival in the spleen were followed, revealing inoculum destruction within 15 days. With both strains Ye8081 and WA (0:8, harbouring a 42-Md plasmid), the kinetics of bacterial growth ended in the death of mice. The early spleen bacterial uptake was the same with all strains studied, whether plasmid-harbouring or plasmid-less derivatives. In this study, virulent strain Ye8081 and both low-virulent IP383 and Ye9576 were shown to synthesize antigenically related outer membrane polypeptides plasmid-encoded at 37 degrees C and previously considered as virulence determinants.
mesh_terms: D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D010957:Plasmids; D012703:Serotyping; D013154:Spleen / Q000382:microbiology; D013997:Time Factors; D014774:Virulence; D015008:Yersinia enterocolitica / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*
chemical_list: D001425:Bacterial Outer Membrane Proteins