[Ratio of spontaneous and o-aminoazotoluene-induced hepatocarcinogenesis in mice].
No correlation was found between the frequency of spontaneous and o-aminoazotoluene (o-AAT)-induced hepatic tumours in mice. High susceptibility to tumour induction with o-AAT in mice both genetically susceptible (strains CBA and A/He) and resistant (strains DBA/2J and DD) to spontaneous hepatocarcinogenesis was detected. The CC57BR mice predisposed to spontaneous hepatomas were insensitive to their induction with o-AAT. The model described may be helpful in studies of the nature of the initiation and promotion stages of hepatocarcinogenesis.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D004198:Disease Susceptibility; D008114:Liver Neoplasms, Experimental / Q000453:epidemiology / Q000209:etiology* / Q000401:mortality; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D009762:o-Aminoazotoluene / Q000633:toxicity*
D001391:Azo Compounds; D009762:o-Aminoazotoluene
Sootnoshenie spontannogo i indutsirovannogo o-aminoazotoluolom gepatokantserogeneza u mysheĭ.