[Activity of lactic dehydrogenase and its isoenzyme in intestinal metaplasia of the gastric mucosa, early and advanced gastric carcinoma].
Lactic dehydrogenase (LDH) and its isoenzyme in the serum, gastric juice and mucosal tissue were studied in 83 patients with severe intestinal metaplasia, early and advanced gastric carcinoma, ulcer and superficial gastritis. The LDH activity in these tissues was lower in superficial gastritis and ulcer than in gastric carcinoma and intestinal metaplasia, while their isoenzyme activity was nearly normal. The LDH activity in the intestinal metaplasia was near to that in gastric carcinoma and its isoenzyme was transformed from H into M fraction, similar to gastric carcinoma. Thus, the relation between gastric carcinoma and intestinal metaplasia is reflected in the LDH activity. Because the differentiation of benign from malignant gastric disease by means of LDH assay is difficult and its isoenzyme possessing an individual characteristic distribution, this method may only be auxiliary in the differential diagnosis.
D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000201:enzymology*; D005757:Gastritis, Atrophic / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008679:Metaplasia; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000473:pathology
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase