[Metabolic effects of papaverine and pentamine combinations with nicotinic and succinic acids in experimental vascular pathology in rabbits].
It has been shown in rabbit experiments that a 7-day administration of papaverine and pentamine in doses of 1 mg/kg without administering nicotinic (4 mg/kg) and succinic (50 mg/kg) acids and in conjunction with their administration given in courses led to a distinct change in carbohydrate-phosphorus metabolism in blood vessels of rabbits with pituitrin hypertension. The drug combination removed unfavourable metabolic shifts seen in the vessels in the experimental pathology more effectively than separate drug administration.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002339:Carotid Arteries / Q000378:metabolism; D005260:Female; D005263:Femoral Artery / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009243:NAD / Q000378:metabolism; D009539:Nicotinic Acids / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010208:Papaverine / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D011817:Rabbits; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid; D014684:Venae Cavae / Q000378:metabolism
D007773:Lactates; D009539:Nicotinic Acids; D010710:Phosphates; D011773:Pyruvates; D000644:Quaternary Ammonium Compounds; D013386:Succinates; D009243:NAD; D019344:Lactic Acid; C040648:pentamine; D019289:Pyruvic Acid; D019802:Succinic Acid; D010208:Papaverine
Metabolicheskie effekty kombinatsiĭ papaverina i pentamina s nikotinovoĭ iantarnoĭ kislotami pri eksperimental'noĭ sosudistoĭ patologii u krolikov.