Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part I: Pharmacokinetics in rats.
Fluorescein-labelled sulodexide pharmacokinetics and urinary excretion were studied in the rat after intravenous administration. The compound showed a pharmacokinetic pattern similar to that of heparin and the plasmatic levels were linearly correlated with anti-factor Xa activity and logarithmically with lipoprotein lipase activation. The compound is well eliminated by urinary route; the urinary recovery was 50% in 24 h and 67% 48 h after administration. The results obtained indicate that fluorescein labelling of glycosaminoglycans may be a valid tool for pharmacokinetics and distribution studies in the laboratory animals.
D000818:Animals; D019793:Fluorescein; D005452:Fluoresceins; D006025:Glycosaminoglycans / Q000097:blood / Q000378:metabolism* / Q000652:urine; D000960:Hypolipidemic Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005452:Fluoresceins; D006025:Glycosaminoglycans; D000960:Hypolipidemic Agents; C007858:glucuronyl glucosamine glycan sulfate; D019793:Fluorescein