title: [Prevention of disorders of the contractile function of the heart after chemical induction of lipid peroxides].
abstract: Adriblastin was shown to activate considerably lipid peroxidation processes in the heart muscle, mostly through the suppression of antioxidant enzyme (superoxidedysmutase and catalase) activity, with myocardial contractility declining essentially as a result. Pretreatment with the synthetic antioxidant ionol prevented the adriblastin-induced depression of myocardial contractility.
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000139:chemically induced*; D002374:Catalase / Q000378:metabolism; D004317:Doxorubicin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D008054:Lipid Peroxides / Q000378:metabolism*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D012545:Schiff Bases / Q000032:analysis; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D012545:Schiff Bases; D002084:Butylated Hydroxytoluene; D004317:Doxorubicin; D002374:Catalase; D013482:Superoxide Dismutase
vernacular_title: Preduprezhdenie narusheniĭ sokratitel'noĭ funktsii serdtsa pri khimicheskoĭ induktsii perekisnogo okisleniia lipidov.