[Thyroid and C-cell system function during prolonged rotation (morphobiochemical research)].
The thyroid and parathyroid glands of 65 Wistar rats centrifuged for 30 days at 1.1 and 2.0 G were examined histologically and biochemically. The centrifugation led to a higher activity to C-cells, an increased rate of thyro-calcitonin (TCT) synthesis and excretion, i.e. C-cell degranulation, and a significant (two-fold) increase of TCT in plasma. The stimulation effect of the TCT-producing system persisted during 7-post-rotation days and was very distinct in the animals exposed to 2.0 G. There were no morphological changes in the parathyroid glands or in the PTH concentration in the plasma.
D000818:Animals; D002116:Calcitonin / Q000097:blood; D003102:Colloids; D006651:Histocytochemistry; D010280:Parathyroid Glands / Q000166:cytology / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation / Q000009:adverse effects*; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects
D003102:Colloids; D010281:Parathyroid Hormone; D002116:Calcitonin
Sostoianie shchitovidnoĭ zhelezy i sistemy C-kletok pri dlitel'nom vrashchenii (morfobiokhimicheskoe issledovanie).