title: GM1 monosialoganglioside inner ester induces early recovery of striatal dopamine uptake in rats with unilateral nigrostriatal lesion.
abstract: The experiments concerned the effect of parenteral administration of GM1 monosialoganglioside inner ester on the uptake of [3H]dopamine ([3H]DA) in synaptosomes prepared from the corpus striatum of rats with a unilateral lesion of the nigrostriatal pathway. In the animals treated with the ganglioside, starting on the 2nd day after lesion, the apparent Vmax of [3H]DA uptake (desipramine-insensitive) showed a marked recovery (from 10% to 33% of the controlateral side) as early as after 3 days of treatment, with no changes in the apparent Km values.
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004952:Esters / Q000494:pharmacology; D005677:G(M1) Ganglioside / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013378:Substantia Nigra / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects
chemical_list: D004952:Esters; D011954:Receptors, Dopamine; D005677:G(M1) Ganglioside; D007980:Levodopa; D004298:Dopamine