Serum sickness.
Serum sickness can be induced experimentally in the rabbit by injecting a foreign protein. The pathophysiology has been well described. A similar illness is seen in man after injection of heterologous serum, and well as many other drugs. Included is a discussion of immunopathologic studies of human serum sickness and serum sickness-like diseases, diagnosis, prevention, and treatment.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism / Q000502:physiology; D002199:Capillary Permeability; D003533:Cyproheptadine / Q000627:therapeutic use; D004195:Disease Models, Animal; D006509:Hepatitis B / Q000150:complications / Q000503:physiopathology; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use; D011817:Rabbits; D012713:Serum Sickness / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
D000936:Antigen-Antibody Complex; D003533:Cyproheptadine; D006919:Hydroxyzine