title: [Use of thiamine for correcting the immune response during physical loading].
abstract: A study was made of the effect of thiamine on the development of the immune response under exercise. It was established that the 4-hour swimming inhibited the development of the immune response to sheep red blood cells in Wistar rats fed about 40 g thiamine per day with the diet. Additional administration of 100 g vitamin increased the intensity of the immune response after exercise. The serum from the swimming rats suppressed the development of the immune response in intact animals. Thiamine did not produce any effect on the exercise-induced synthesis and release of immunosuppressant factors but reduced the sensitivity of effector cells of the humoral immune response to the action of those factors.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D007106:Immune Sera / Q000494:pharmacology; D007108:Immune Tolerance / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013550:Swimming; D013831:Thiamine / Q000378:metabolism / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D007106:Immune Sera; D013831:Thiamine
vernacular_title: Ispol'zovanie tiamina dlia korrektsii immunnogo otveta pri fizicheskoĭ nagruzke.