Pig thyroid spectrin. A membrane-associated protein related in structure and function to brain spectrin.
Thyroid spectrin has been obtained pure from pig thyroid glands. This protein, composed of two non-identical polypeptide chains of 240 kDa and 235 kDa, appears to possess the same structural and immunological properties as well as the same calmodulin and actin-binding properties as brain spectrin. Through cross-linking of actin filaments it is a potent gelation factor for F-actin solutions. It represents one of the major protein of the cytoskeleton underlying the thyroid plasma membrane together with myosin, alpha-actinin and actin.
D000199:Actins / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D002462:Cell Membrane / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007120:Immunochemistry; D010455:Peptides / Q000032:analysis; D011485:Protein Binding; D013049:Spectrin / Q000302:isolation & purification*; D013552:Swine; D013961:Thyroid Gland / Q000032:analysis*; D014783:Viscosity
D000199:Actins; D010455:Peptides; D013049:Spectrin