Density of granulomonocytic colony-forming cells (GM-CFC's) in myelofibrosis.
The circulating GM-CFC density-distribution profile was studied in 19 cases of myelofibrosis with myeloid metaplasia. The distribution profile for the population studied appeared to be similar to that of normal bone marrow GM-CFC's but shifted toward lower densities in comparison with normal circulating GM-CFC's. For individual patients, it appeared that the greater the circulating blood GM-CFC's concentration, the lower the mean density. It appears likely that the premature release into blood of the GM-CFC's in myelofibrosis is a property of the neoplastic haematopoietic stem cell clone at the core of the disease.
D001772:Blood Cell Count; D002469:Cell Separation; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D006098:Granulocytes; D006412:Hematopoietic Stem Cells / Q000473:pathology* / Q000502:physiology; D006801:Humans; D009000:Monocytes; D055728:Primary Myelofibrosis / Q000097:blood*