Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli.
The antagonistic action of aligeron as compared to that of papaverine against different smooth muscle stimuli was studied in experiments in vitro. Three series of experiments were conducted: study of the antagonistic action against experimental spasms of isolated organs caused by different spasmogens; determination of the type of antagonism to adrenaline in isolated vas deferens preparation; and study of the antagonistic action against vasoconstrictor effects of noradrenaline and adrenaline in isolated perfused rabbit renal artery. Aligeron showed a broad spectrum of antagonistic action against different spasmogens in different isolated organs. Its effect was more pronounced than that of papaverine. The antagonism was of the non-competitive type. The experiments on isolated perfused rabbit artery showed the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline. The results suggest the clinical use of aligeron in conditions associated with increased release of these vasoactive substances.
D000818:Animals; D002936:Cinnarizine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004837:Epinephrine / Q000037:antagonists & inhibitors; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010208:Papaverine / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors*
D014662:Vasoconstrictor Agents; D002936:Cinnarizine; C021591:Aligeron; D010208:Papaverine; D009638:Norepinephrine; D004837:Epinephrine