[Determination of liver circulation with radionuclides. I. Modification of 99mTc-MMS accumulation in the liver using drugs].
The rate constant of liver uptake of 99mTc-labelled millimicrospheres is taken to be a measure of nutritive RES blood supply. Animal experiments were used to determine whether this constant--similar to that of other colloids--is affected by drugs such as heparin or corticosteroids which alter RES function. In rabbits, the scatter of k between individuals is quite large, with a standard deviation of 27%, whereas the scatter within an individual appears to be acceptable (8%). Heparin does not change the value of k significantly, whereas prednisolone in a dose of 40 mg/kg BW--a dose that is normal in bolus therapy--reduces k significantly by 21%. If k is determined during such therapy, its reduction may be due to the pharmacological effect and must not be interpreted as a rejection phenomenon.
D000818:Animals; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D008102:Liver Circulation; D008863:Microspheres; D011239:Prednisolone / Q000494:pharmacology*; D011817:Rabbits; D011877:Radionuclide Imaging; D013268:Stimulation, Chemical; D013667:Technetium / Q000378:metabolism
D013667:Technetium; D006493:Heparin; D011239:Prednisolone
Zur Bestimmung der Leberdurchblutung mit Radionukliden. I. Beeinflussung der 99mTc-MMS-Anreicherung in der Leber durch Pharmaka.