Identical laryngeal cancers in two non-twin sibling pairs: case reports and a review of the literature.
The occurrence of identical laryngeal cancers in two nontwin sibling pairs is reported for the first time. To understand the relative importance of genetic and environmental factors in the etiology of laryngeal cancer, the evidence in the literature for the development of identical cancers in genetically unrelated and related pairs sharing the same environments was examined.
D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D004777:Environment; D004825:Epiglottis / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000532:radiotherapy / Q000601:surgery; D007825:Laryngectomy; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D012907:Smoking