[Synthesis and pharmacologic study of 6-(amino-2 ethyl) benzoxazolinones].
Reaction of various amines on 6-(2-bromoethyl)benzoxazolinone or its N-methylated derivative provided eleven new 6-substituted aminoalkyl analogues. In a pharmacological evaluation, several compounds bearing an arylpiperazinic moiety were found to possess significant effects on arterial blood pressure and on the central nervous system; two of them showed interesting analgesic activity.
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001583:Benzoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D000700:Analgesics; D000959:Antihypertensive Agents; D001583:Benzoxazoles; D006993:Hypnotics and Sedatives
Synthèse et étude pharmacologique d'(amino-2 éthyl)-6 benzoxazolinones.