Suppression of PCP-induced behavioral arousal in the rat by yohimbine pretreatment.
The ability of yohimbine pretreatment to block PCP-induced increases in general motor behavior and head bobbing was assessed in adult female Sprague-Dawley rats. PCP-induced (5 mg/kg i.p.) increases in motor activity were significantly antagonized by yohimbine (5 mg/kg i.p.). More specific PCP-induced (5 mg/kg i.v.) head bobbing was antagonized in a dose-related manner by yohimbine (2.5 and 5 mg/kg i.p.). These data may lead to a better understanding of the mode of action of PCP.
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D005260:Female; D009043:Motor Activity / Q000187:drug effects*; D010622:Phencyclidine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015016:Yohimbine / Q000494:pharmacology*
D015016:Yohimbine; D010622:Phencyclidine