Satietin, a blood-borne glycoprotein in the regulation of food intake.
Satietin and satietin-D, two closely related 50,000 dalton anorectic glycoproteins were isolated from human serum. The isoelectric point of satietin is 7.0, it contains 14-15% amino acids and 70-75% carbohydrates. Satietin-D has an isoelectric point of 3.0, a protein content of 20-22% and a carbohydrate content of 55-60%. Both satietin and satietin-D are potent, long-acting and highly selective suppressants of food intake in the rat. The hypothesis was forwarded that satietin and satietin-D may belong to a system which brings into being the rate-limiting blood-borne satiety signalization in the negative feedback of food intake.
D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000097:blood*; D004435:Eating; D006020:Glycopeptides / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D051381:Rats; D013045:Species Specificity
D001067:Appetite Depressants; D006020:Glycopeptides; C035102:satietin