[Relation between the dynamics of EEG indices after a single dose of the tranquilizer phenazepam and its efficacy during a course of treatment of patients with borderline neuropsychological disorders].
The effect of a single phenazepam dose (1-2 mg) on the power of EEG frequency ranges, their interhemispherical asymmetry and the level of intra- and inter-hemispherical correlations was studied in 78 patients with borderline neuropsychic disturbances divided into four groups depending on the efficiency of phenazepam therapy. Different variants of reactions of EEG parameters related to the characteristics of the clinical action of the drug in different groups of patients were identified. High therapeutical efficacy of phenazepam was associated with a complex of bilateral, relatively generalized changes in power of beta- and alpha-ranges, characteristic of action of benzodiazepins and combined with a predominantly right-side decrease in theta-range and the absence of any significant dynamics of the initially intact correlations of the EEG. Patients with inadequate efficiency of phenazepam showed a topographically-limited and incomplete complex of changes in the power of frequency ranges. They also had alterations in the level of EEG correlation.
D000293:Adolescent; D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009497:Neurotic Disorders / Q000188:drug therapy* / Q000503:physiopathology; D010554:Personality Disorders / Q000188:drug therapy
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam
Sviaz' dinamiki pokazateleĭ EEG posle odnokratnogo priema trankvilizatora fenazepama i ego éffektivnosti pri kurosovoĭ terapii bol'nykh s pogranichnymi nervno-psikhicheskimi rasstroĭstvami.