Effect of ovariectomy and estrogen on [3H]imipramine binding to different regions of rat brain.
In rats, 35 days after ovariectomy, the number of [3H]imipramine binding sites increased more than 200% in striatum, hippocampus and hypothalamus but it did not change in cerebral cortex and brain-stem. Estradiol-17 beta acting in vitro inhibited [3H]imipramine binding in control membranes of striatum, hippocampus and hypothalamus, but not in the same regions from ovariectomized rats.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D007099:Imipramine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D066298:In Vitro Techniques; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D004967:Estrogens; D004958:Estradiol; D007099:Imipramine