Failure of nimodipine to reverse acute experimental spinal cord injury.
The calcium-channel blocking agent, nimodipine, was administered to cats for 5 days after acute experimental SCI. Six weeks after injury, no significant differences in neurologic recovery or white matter tissue preservation at the injury site were found between treated and control animals.
D000208:Acute Disease; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002415:Cats; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D009553:Nimodipine; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D002121:Calcium Channel Blockers; D009539:Nicotinic Acids; D009553:Nimodipine