A perspective of chromosome displacement as a primary step in the induction of aneuploidy.
This paper considers whether the model proposing chromosome displacement as a primary step in the induction of mitotic aneuploidy (Ford and Roberts, 1983a) is consistent with experimental data relating to spindle structure, chromosomal attachment to spindles, the promotion of aneuploidy and the relative involvement of the different human chromosomes in aneuploidy. It is concluded that the model is consistent with all the parameters thus far tested for autosomal chromosomes.
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D001773:Blood Cells / Q000166:cytology; D002877:Chromosomes, Human / Q000502:physiology / Q000648:ultrastructure*; D003703:Demecolcine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008677:Metaphase / Q000187:drug effects; D008854:Microscopy, Electron; D008875:Middle Aged; D008957:Models, Genetic; D008941:Spindle Apparatus / Q000187:drug effects
D003703:Demecolcine