Plasma flupentixol concentrations and clinical response in acute schizophrenia.
Twenty-three acutely psychotic inpatients treated with flupentixol were included in the study. Steady-state plasma concentrations were compared with therapeutic outcome in a routine clinical setting. The threshold concentration for satisfactory antipsychotic effect appeared to be approximately 2 ng/ml. Controlled studies are needed to establish the existence and exact limits of a therapeutic window.
D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002849:Chromatography, Gas; D005260:Female; D005475:Flupenthixol / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013892:Thioxanthenes / Q000097:blood*
D013892:Thioxanthenes; D005475:Flupenthixol