[Comparative study of the effect of basic risk and nutritional factors on the development of ischemic heart disease in a population].
Altogether 39 CHD new cases were detected in a representative random sample of 556 men aged 40-59 in the course of 5 yrs. The patients had a high AP, consumed more alcohol, were more well-fed, older and consumed more refined carbohydrates per 1 kg bw and less cholesterol and vegetable protein. A high density lipoprotein cholesterol level was lower. 50% of all CHD new cases originated from the upper sextile of distribution (17% of values). Risk of CHD development compared to the lower sextile increased 9.5-fold. In considering logistic function 46% of CHD new cases originated from the first four informative characteristics of the upper sextile. Risk of CHD development in the upper sextile was 6 times as high as in the lower sextile. An acute drop of the informative value of the set of 3 characteristics occurred after excluding from the analysis values of the consumption of carbohydrates per 1 kg bw, and differences between values of theoretically anticipated and empirical risk became statistically significant. The study showed the interrelationship of alimentary factors and risk factors in CHD development. A raised consumption of refined carbohydrates and alcohol consumption enhanced the effect of such risk factors as overweight, arterial hypertension and disorders of the blood lipid spectrum regarded as the main causes of CHD development in males aged 40-59.
D000328:Adult; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009031:Moscow; D009747:Nutritional Physiological Phenomena; D011379:Prognosis; D012306:Risk; D014505:Urban Population
D002791:Cholesterol, Dietary; D004040:Dietary Carbohydrates
Sravnitel'noe izuchenie vliianiia osnovnykh faktorov riska i pitaniia na razvitie ishemicheskoĭ bolezni serdtsa v populiatsii.