Antagonism of picrotoxin against the taming effect of carbamazepine on footshock induced fighting behavior in mice.
Carbamazepine (10 and 20 mg/kg, i.p., P less than 0.01; 40 mg/kg p.o., P less than 0.01), Li2CO3 (200 mg/kg, i.p., P less than 0.01; 200 mg/kg, p.o., P less than 0.05), diazepam (0.5 mg/kg, i.p., P less than 0.01) and haloperidol (0.5 mg/kg, i.p., P less than 0.01) significantly decreased the number of fighting episodes induced by footshock in mice. Picrotoxin (0.3 mg/kg, s.c.) and bicuculline (0.5 mg/kg, s.c.) antagonized the effect of carbamazepine or diazepam completely. Our present results suggest that the taming property of carbamazepine in the footshock model have some relation with the GABAergic mechanism.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002220:Carbamazepine / Q000037:antagonists & inhibitors*; D003975:Diazepam / Q000494:pharmacology; D004597:Electroshock; D006220:Haloperidol / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D001640:Bicuculline; D002220:Carbamazepine; D003975:Diazepam; D006220:Haloperidol; D008094:Lithium; D010433:Pentylenetetrazole; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid