[Antagonism of parmidin to kinin effects].
Parmidin in 10(-9)-10(-5) g/ml concentrations displays specific and competitive antagonism to spasmogenic effects of bradykinin and methionyl-lysil-bradykinin on isolated segments of the guinea pig ileum, rat uteral cornua, cat jejunum and spiral strips of the rabbit aorta. Its antagonism to the spasmogenic effect of lysil-bradykinin is of both competitive and non-competitive character. In rats parmidin in 100 mg/kg dose decreased the paw edema, induced by kinins but it did not influence the similar effect of histamine and that of prostaglandin F2.
D000818:Animals; D001920:Bradykinin / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D002219:Carbamates / Q000494:pharmacology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007609:Kallidin / Q000037:antagonists & inhibitors; D007705:Kinins / Q000037:antagonists & inhibitors*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011727:Pyridinolcarbamate / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D002219:Carbamates; D007705:Kinins; D007609:Kallidin; C018103:bradykinin, Met-Lys-; D011727:Pyridinolcarbamate; D001920:Bradykinin
Izuchenie antagonizma parmidina k éffektam kininov.