Effects of sodium L-ascorbate and related compounds on rat stomach carcinogenesis initiated by N-methyl-N'-nitro-N-nitrosoguanidine.
The modifying effects of 3 antioxidants, sodium L-ascorbate (SA), ascorbic acid (AA) and sodium erythorbate (SE) on two-stage gastric carcinogenesis in F344 rats initiated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated. Administration of 5% SE in the diet significantly decreased the incidence of dysplasia of the pylorus and, more marginally the incidence of papilloma of the forestomach, whereas administration of 5% and 1% SA and 5% AA in the diet was not associated with effect. These results suggest that SE exerts a weak inhibitory effect on gastric carcinogenesis.
D000818:Animals; D001205:Ascorbic Acid / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D003043:Cocarcinogenesis; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011916:Rats, Inbred F344; D013274:Stomach Neoplasms / Q000139:chemically induced*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D008769:Methylnitronitrosoguanidine; C005056:isoascorbic acid; D001205:Ascorbic Acid