The influence of flumequine on the resistance of the coliform flora of chickens to the agent.
Flumequine (1 g/l) was administered to healthy young chickens in the drinking water for 5 days. A transient increase in the incidence of resistance to flumequine (4 micrograms/ml) was recorded in faecal coliform isolates after administration. Cross-resistance with nalidixic acid was demonstrated, but there was no evidence of cross-resistance to ampicillin, chloramphenicol, kanamycin, streptomycin, sulphadiazide, tetracycline and trimethoprim.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002645:Chickens / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D005243:Feces / Q000382:microbiology; D024841:Fluoroquinolones; D009268:Nalidixic Acid / Q000494:pharmacology; D011807:Quinolizines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011807:Quinolizines; D009268:Nalidixic Acid; C012976:flumequine