Inducibility of chromosome aberrations by steroid hormones in cultured Chinese hamster ovary cells.
The effect of steroid hormones on the chromosomes of cultured Chinese hamster ovary (CHO) cells was studied. It was noticed that estradiol-17 beta, estrone, estriol and ethynyl estradiol were effective in producing various types of chromosome aberrations. The percentage of these abnormalities increased with increasing concentrations of steroids used. The importance of detailed and long-term investigations on the influence of these compounds on mammalian chromosomes is discussed.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003276:Contraceptives, Oral / Q000633:toxicity; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000633:toxicity; D004967:Estrogens / Q000633:toxicity*; D005260:Female; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects
D003276:Contraceptives, Oral; D004967:Estrogens; D004958:Estradiol