[The influence of chronic renal insufficiency on the demethylating activities of various cytochrome P-450 subspecies in humans].
Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly metabolized by phenobarbital-inducible cytochrome P-450 (P-450PB). That's why the half life of caffeine and the elimination of the main metabolites of metamizol were used as parameters in vivo characterizing both groups of the cytochrome P-450-complex. The influence of chronic renal insufficiency was investigated (8 patients in the stage of compensated retention, creatinine in serum 380-1280 mumol X l-1, and 6 hemodialyzed patients, here only metamizol elimination was established). Both the caffeine and the metamizol eliminations of patients with chronic renal insufficiency are not different from those of healthy volunteers. We concluded that the demethylation activity of the cytochrome P-450-complex is not distinctly influenced by chronic renal insufficiency.
D000675:Ampyrone / Q000378:metabolism; D001711:Biotransformation; D002110:Caffeine / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000201:enzymology*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D007527:Isoenzymes; D000675:Ampyrone; D002110:Caffeine; D003577:Cytochrome P-450 Enzyme System
Einfluss der chronischen Niereninsuffizienz auf durch verschiedene Cytochrom P-450-Subspezies katalysierte Demethylierungsaktivitäten beim Menschen.