Paralysis and lipofuscin-like pigmentation of farm stock caused by the plant, Trachyandra laxa var. laxa.
A paralytic condition of farm stock in South West Africa, characterized by prominent neuronal and some mild extraneuronal pigmentation, is described. The distribution of the pigment, which was mainly located in the larger neurones of the brain and spinal cord, is given. Experimental evidence, obtained by feeding the plant, is presented that the condition is caused by Trachyandra laxa var. laxa. The histochemical features of the pigment proved to be compatible with a lipofuscin.
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology; D006734:Horse Diseases / Q000209:etiology; D006736:Horses; D008062:Lipofuscin / Q000032:analysis*; D009474:Neurons / Q000032:analysis / Q000473:pathology; D010243:Paralysis / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010859:Pigmentation Disorders / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010860:Pigments, Biological / Q000032:analysis*; D010939:Plant Poisoning / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology; D013116:Spinal Cord / Q000032:analysis / Q000473:pathology
D008062:Lipofuscin; D010860:Pigments, Biological