Hyperbaric oxygen therapy for radiation myelitis.
Radiation therapy may damage healthy tissues adjacent to tumor. Hyperbaric oxygen therapy (HBO) is useful in treating soft tissue and osteoradionecrosis. In addition, HBO has been recommended to treat radiation-induced myelitis. We used radiation to induce a predictable myelitis in the spinal cords of rats who were randomized into treatment (HBO) and control groups 8 wk after irradiation. Serial neurologic examination showed no benefit or harm as a result of HBO. This small pilot study did not demonstrate any clinically significant benefit of HBO for radiation myelitis in rats.
D000818:Animals; D005260:Female; D006931:Hyperbaric Oxygenation; D009187:Myelitis / Q000628:therapy*; D011833:Radiation Injuries, Experimental / Q000628:therapy*; D051381:Rats; D013116:Spinal Cord / Q000528:radiation effects*