The use of iohexol in pediatric urography: a comparative study with meglumine diatrizoate.
In a prospective study the nephrotoxicity of iohexol, a new non-ionic contrast medium, was compared with meglumine diatrizoate. Plasma creatinine, BUN, creatinine clearance, urinalysis and the urinary excretion of N-acetyl glucosaminidase (NAG), gamma glutamyl transpeptidase (GGT) and muramidase (MU) were determined prior to and following intravenous pyelography. A significant rise in the enzyme excretion was observed in patients who received iohexol and diatrizoate. Statistical analysis failed to demonstrate any difference in nephrotoxicity between the two iodinated contrast media.
D000293:Adolescent; D001806:Blood Urea Nitrogen; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000009:adverse effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004798:Enzymes / Q000652:urine; D005260:Female; D006801:Humans; D007463:Iodobenzoates; D007472:Iohexol; D008297:Male; D011446:Prospective Studies; D011507:Proteinuria; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014567:Urography / Q000009:adverse effects / Q000379:methods*
D003287:Contrast Media; D004798:Enzymes; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol; D003404:Creatinine