title: [Interaction of acrylates with the microsomal oxidation system in the rat liver].
abstract: Esters of acrylic and methacrylic acids (methyl acrylate, methyl methacrylate, butyl acrylate, butyl methacrylate) binding with cytochrome P-450 in rat liver microsomes, formed the spectral complexes of the first order with maximal extinction at 381-388 nm and minimal--at 416-425 nm. Dimethylaniline, used as a classical substrate of oxidation in reactions catalyzed by cytochrome P-450, inhibited the complexes formation by the mixed type. Acrylates increased the oxygen consumption and NADPH oxidation in rat liver microsomes.
mesh_terms: D000179:Acrylates / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D013379:Substrate Specificity
chemical_list: D000179:Acrylates; D009249:NADP; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Vzaimodeĭstvie akrilatov s sistemoĭ mikrosomal'nogo okisleniia pecheni krys.