title: Food intake, body weight and lordosis in male and female mongolian gerbils: effects of ovarian steroids.
abstract: The effects of gonadectomy and ovarian hormone treatment on food intake, body weight, and lordosis in male and female Mongolian gerbils were examined. In female gerbils, a significant decrease in food intake and body weight was observed after ovariectomy, with estradiol benzoate (1, 10, or 100 micrograms/day) increasing food intake in a dose dependent fashion. However, the dose of estrogen (1 microgram) that restored food intake and body weight to control levels in ovariectomized animals was lower than that required to elicit maximal sexual receptivity. Progesterone, when given in conjunction with estrogen, significantly facilitated the effect of estrogen on food intake without further altering body weight. In male gerbils, castration produced a significant but transient increase in body weight and a delayed increase in food intake. Unlike female gerbils, male gerbils exhibited no significant alterations in food intake, body weight, or lordosis in response to treatment with ovarian steroids. The present results are compared to those obtained in other species.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D006224:Cricetinae; D004435:Eating / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005849:Gerbillinae; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D011187:Posture; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013045:Species Specificity
chemical_list: D011374:Progesterone; D004958:Estradiol