[Cerebellar atrophy in epileptic patients: computer tomography study].
We examined the CT-scans of 310 patients with epilepsy and found a cerebellar atrophy (CA) in 56 cases. 8 of them concerned the cerebellar hemispheres and 48 the vermis. The CA was predominantly observed in patients treated with phenytoin, who had experienced one or more phenytoin intoxications. The combination of phenytoin and carbamazepine resulted in a high risk of acquiring a CA. The CA did not depend on the age of the patients or on the presence of major generalised tonic-clonic seizures.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D001284:Atrophy; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed
D000927:Anticonvulsants
Zur Kleinhirnatrophie bei Epilepsiekranken: Eine computertomographische Untersuchung.