title: Expression and modulation of estrogen receptors in human breast cancer.
abstract: Estrogen receptors have been traced at the tissue level in premalignant and malignant changes of human mammary gland by an immunoperoxidase technique using a monoclonal antibody against the receptor protein. Proliferative premalignant cells show an increased and homogeneous expression of the estrogen receptor by this technique; it seems that a constitutive expression of the receptor may play a role in the promotional carcinogenetic process. Moreover, infiltrating tumors show a striking heterogeneity in the cellular expression of estrogen receptor, which seems related to differentiation level.
mesh_terms: D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000032:analysis*; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D000911:Antibodies, Monoclonal; D011960:Receptors, Estrogen