Tumor-inhibitory effect of intralesional injection of bradykinin and immunostimulants in mice.
Intralesional injection of bradykinin at the dose of 500 micrograms or 1000 micrograms in oil or gelatin was effective in inhibiting the growth of Sa 180 cells in ddY mice. Ulcer formation in tumor was observed at a high rate in these bradykinin-treated groups. Combined use of bradykinin with a streptococcal preparation (OK-432) was more effective in inhibition of tumor growth compared with that in oil. Similar bradykinin-induced inhibition was observed in a spontaneous mammary tumor of C3H (MM 46) mice. These results suggest that increase in cellular influx and activation of infiltrated cells within a tumor are important factors to induce tumor inhibition effectively.
D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D001920:Bradykinin / Q000627:therapeutic use*; D004655:Emulsions; D005260:Female; D005780:Gelatin; D008297:Male; D051379:Mice; D009821:Oils; D010844:Picibanil / Q000627:therapeutic use*; D012510:Sarcoma 180 / Q000188:drug therapy*; D013997:Time Factors
D001688:Biological Products; D004655:Emulsions; D009821:Oils; D010844:Picibanil; D005780:Gelatin; D001920:Bradykinin