Local treatment of necrotizing scleritis with cyclosporin A.
A report is presented on an 83-year-old female patient with seropositive rheumatoid arthritis who developed a necrotizing scleritis of the right eye. The clinical course could not be influenced by indomethacin, cysteine, and the cytostatic chlorambucil. Local cyclosporin treatment, however, which was initiated after a 4-week therapy-free period, led to considerable improvement within a few days. The disease disappeared after 6 weeks of treatment. There is no recurrence as yet, the follow-up period being 13 months.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D009336:Necrosis; D009883:Ophthalmic Solutions; D012590:Sclera / Q000473:pathology; D012699:Serology
D003524:Cyclosporins; D009883:Ophthalmic Solutions