[Glycoside poisoning in experimental heart failure and its drug correction].
It has been demonstrated in experiments on 420 rats that antiadrenergic, antihistamine, antihypoxic, anabolic, antiarrhythmic and diuretic agents have different effects on the cardiotoxicity of strophanthine K for intact animals and in experimental heart insufficiency of different genesis. The pharmacological analysis revealed some risk factors capable of provoking glycoside intoxication in circulatory failure. Approaches to the goal-oriented drug correction of the risk factors are proposed.
D000818:Animals; D002301:Cardiac Glycosides / Q000506:poisoning*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004347:Drug Interactions; D004361:Drug Tolerance; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013328:Strophanthins / Q000633:toxicity
D002301:Cardiac Glycosides; D002317:Cardiovascular Agents; D013328:Strophanthins; D007545:Isoproterenol
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