Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma.
Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.
D000818:Animals; D004032:Diet; D004041:Dietary Fats; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D004041:Dietary Fats; D014801:Vitamin A; D014810:Vitamin E; D008770:Methylnitrosourea; D005978:Glutathione