Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine and norepinephrine release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils.
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) and norepinephrine (NE) release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils were examined. ACh and NE release from cortical slices of Mongolian gerbils were increased 1 hr after the ligation of bilateral carotid arteries. Pretreatment of MCI-2016 (25 mg/kg, i.p.) attenuated the increase in the release of both neurotransmitters. These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002339:Carotid Arteries / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism*; D005849:Gerbillinae; D008026:Ligation; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D013997:Time Factors
D000928:Antidepressive Agents; D001559:Benzhydryl Compounds; D000109:Acetylcholine; D009638:Norepinephrine; C031906:bifemelane