title: [Toxicity of an original antiemetic preparation dimetpramid].
abstract: A new original drug dimetpramid injected per os into mice and rats exhibits moderate toxicity, exerts a weak irritating action on the mucous membranes. The drug is capable of penetrating via the unaffected skin, producing systemic effects. With all routes of administration the drug may have a moderate inhibitory action on ovarian function and the manifestation of the hypotensive effect.
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000008:administration & dosage / Q000633:toxicity*; D001549:Benzamides / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors
chemical_list: D000932:Antiemetics; D001549:Benzamides; C037141:dimetpramid
vernacular_title: Toksichnost' original'nogo protivorvotnogo preparata dimetpramida.