Role of mesencephalic glycine in locomotor activity.
Microinjection of glycine (20 micrograms) into the ventral mesencephalon of rats caused a stimulation of locomotor activity. Microinjection of haloperidol (5 micrograms) into the nucleus accumbens immediately before the glycine injection did not reduce this locomotor stimulation. In rats with 6-hydroxydopamine-induced destruction of mesolimbic dopamine (DA) terminals the ability of apomorphine (0.1 mg/kg, s.c.) to stimulate locomotor activity was reduced by microinjection of the glycine antagonist strychnine into the ventral mesencephalon. Increased glycinergic activity in the ventral mesencephalon therefore appears to stimulate locomotor activity by a mechanism other than the activation of mesolimbic DA neurons.
D000818:Animals; D001931:Brain Mapping; D005998:Glycine / Q000008:administration & dosage / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000008:administration & dosage
D012965:Sodium Chloride; D006220:Haloperidol; D005998:Glycine