Mild and regiospecific synthesis of 18F-labelled vinyl fluoride using [18F]fluorine reacted with silane.
A labelled vinyl fluoride of biological interest was prepared in good radiochemical yield by direct fluorination of the corresponding silane. The synthesis of 18F-labelled 4-fluoroantipyrine, a cerebral blood flow tracer, involved the reaction of 4-(trimethylsilyl) antipyrine with [18F]F2 (0.5% fluorine in neon) or 5% F2 in nitrogen in freon-11 as solvent. A radiochemical (chemical) yield of about 18% (42%) was obtained in a 25-min synthesis. The radiochemical and chemical purity of the final products was 99% after purification by HPLC.
D000180:Acrylic Resins; D017438:Bisphenol A-Glycidyl Methacrylate; D003188:Composite Resins; D005461:Fluorine; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011868:Radioisotopes; D014753:Vinyl Compounds / Q000138:chemical synthesis*
D000180:Acrylic Resins; D003188:Composite Resins; D007202:Indicators and Reagents; D011868:Radioisotopes; D014753:Vinyl Compounds; C016829:vinyl fluoride; D005461:Fluorine; D017438:Bisphenol A-Glycidyl Methacrylate; C033930:Silar (3M)