Effects of ambient temperature on the half-life and dosage regimen of amikacin in the gopher snake.
Eight gopher snakes were given amikacin (5 mg/kg of body weight IM) and were housed at ambient temperatures of 25 C or 37 C. Snakes housed at 37 C had a larger volume of distribution, and a more rapid body clearance of amikacin while the apparent half-life was not changed significantly. The minimum inhibitory concentrations of amikacin against isolated snake pathogens were determined at both temperatures. Bacteria were twice as sensitive at 37 C than at 25 C. The data indicated that amikacin should be given IM at a dose schedule of 5 mg/kg (loading dose) followed by 2.5 mg/kg every 72 hours, and that snakes should be housed near the high end of their preferred optimum ambient temperature during treatment.
D000583:Amikacin / Q000097:blood*; D000818:Animals; D001831:Body Temperature; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D007612:Kanamycin / Q000031:analogs & derivatives*; D008297:Male; D008657:Metabolic Clearance Rate; D012911:Snakes / Q000097:blood*; D013696:Temperature
D007612:Kanamycin; D000583:Amikacin