[Morphologic indices of the rat heart after colchicine application to the vagus nerve].
By means of the light optic and electron microscopic methods atrial ganglia, myocytes, vessels of the right cardiac chambers have been studied in rats 2 days--3 weeks after application of 100 mcg of colchicine on the right nervus vagus. Certain changes of the neural fibers have been described at the area of the application. In the myocardium the microcirculatory bed, focal edema and hypoxic alterations of the myocyte ultrastructure have been revealed. In the ventrical ganglia destruction of some terminals of the preganglionar fibers, chromatolysis and vacuolization of single neurocytes, as well as intraganglionar granule-containing cells have been found. The changes described take place for 7 days and they nearly completely disappear in 10 days. A suggestion is made that some phenomena, in particular, destruction of the preganglionar fibers and changes of the cardiac microcirculatory bed are connected with certain disturbances of the quick transport of substances in the nervus vagus fibers.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D005726:Ganglia, Parasympathetic / Q000648:ultrastructure; D006321:Heart / Q000294:innervation*; D006325:Heart Atria; D008297:Male; D008833:Microcirculation / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure; D009410:Nerve Degeneration; D051381:Rats; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000187:drug effects* / Q000648:ultrastructure
D003078:Colchicine
Morfologicheskie pokazateli serdtsa krysy v usloviiakh applikatsii kolkhitsina na bluzhdaiushchiĭ nerv.