The hemolytic-uremic syndrome: prognostic significance of neurological abnormalities.
To define the prognostic significance of neurological symptoms in the hemolytic-uremic syndrome (HUS), the records of 68 patients with this syndrome were reviewed. Major neurological symptoms (convulsions and/or coma) occurred in 22 patients. Nine of them had dysregulation of breathing as well. An analysis of other symptoms and characteristics of the disease in these 9 patients revealed a rapid progression of the disease, a high incidence of colitis, and a high mortality rate (8 of the 9 patients) despite adequate seizures control, replacement of renal function and assisted ventilation. We conclude that the prognosis of HUS patients with severe neurological symptoms including dysregulation of breathing is poor.
D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000175:diagnosis; D003131:Combined Modality Therapy; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D006435:Renal Dialysis; D012121:Respiration, Artificial; D012640:Seizures / Q000175:diagnosis