Effects of melphalan on the development of experimental pancreatic cancer.
The effects of melphalan were studied in rats fed raw soya flour and injected with azaserine in order to determine the suitability of this experimental model for testing drugs potentially useful for the treatment of pancreatic cancer. While melphalan did not prevent or delay the development of pancreatic cancer in these rats, the drug significantly lessened the number and size of the premalignant proliferative lesions in the pancreas. It seems that the model is useful both for testing potentially useful therapeutic agents and for analysing some of the processes involved in the development of pancreatic cancer.
D000818:Animals; D001377:Azaserine / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D009696:Nucleic Acids / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000032:analysis / Q000187:drug effects / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D009696:Nucleic Acids; D011506:Proteins; D001377:Azaserine; D008558:Melphalan