Localization of indomethacin induced inhibition of oxygen consumption in mitochondria of the guinea pig gastric mucosa.
The effect of indometacin-Na-trihydrate on oxygen consumption was studied in isolated mitochondria of the guinea pig gastric mucosa. Using various substrates with or without inhibitors it was possible to localize the inhibitory effect on or in the vicinity of complexes I and III of the respiratory chain. Effective concentrations of indometacin were within the range of gastric mucosal concentrations reached with submaximal ulcerogenic doses.
D000818:Animals; D003864:Depression, Chemical; D005753:Gastric Mucosa / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*
D007213:Indomethacin