title: [Morphology of precancerous mucosal changes in the bladder].
abstract: A morphological analysis of 346 biopsy specimens from 140 patients with chronic cystitis permits one to evaluate a nonproliferative and proliferative forms of the disease as well as the squamous-cell metaplasia (leukoplakia) of urothelium as the risk diseases in the development of bladder cancer. Among them only the cases with dysplasia foci of urothelium or the squamous-cell metaplasia with acanthosis or dysplasia from the risk group belonging to bladder precancer. The early ultrastructural signs of urothelial dysplasia are determined; among them the proliferation of the undifferentiated cells with an increased nuclear-cytoplasmic ratio, the disappearance of asymmetrical mutual membrane, vesicular apparatus and cytoplasmic polarity of the superficial cells are to be distinguished.
mesh_terms: D001706:Biopsy; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002908:Chronic Disease; D003556:Cystitis / Q000473:pathology; D006801:Humans; D007971:Leukoplakia / Q000473:pathology; D008137:Longitudinal Studies; D008679:Metaplasia / Q000473:pathology; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000209:etiology / Q000473:pathology*
vernacular_title: Morfologiia predopukholevykh izmeneniĭ slizistoĭ obolochki mochevogo puzyria.