Evidence for an endacoid for the 5HT2 recognition site.
A peptide was partially purified from bovine forebrain which specifically inhibits the binding of [3H]-ketanserin to the 5HT2 recognition site. The peptide has a MW of approximately 6,000 daltons and is partially destroyed by limited proteolysis. We suggest that the peptide is a candidate for an endacoid for the 5HT2 recognition site.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000502:physiology*; D011985:Receptors, Serotonin / Q000378:metabolism*; D014357:Trypsin / Q000494:pharmacology
D009419:Nerve Tissue Proteins; D011985:Receptors, Serotonin; D014357:Trypsin