Hemodialysis clearance of pentobarbital during continuous infusion.
The hemodialysis clearance of pentobarbital during continuous infusion was determined in a 34-year-old man in acute renal failure. Pentobarbital specimens were obtained simultaneously from arterial blood entering and leaving the dialysis machine at five 1-h intervals. The mean hemodialysis clearance of pentobarbital was 22.3 ml/min. Pentobarbital concentration was relatively unaffected throughout the dialysis period, because of the high dose and continuous infusion of a drug with low hepatic intrinsic clearance and a short dialysis period. A large contribution to total body clearance was not evident, and dosage adjustment would have been unwarranted.
D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy; D000328:Adult; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage / Q000097:blood*; D006435:Renal Dialysis
D010424:Pentobarbital