title: Experimental modification of the growth of the bursa of Fabricius in chickens revealed by scanning and transmission electron microscopy.
abstract: The ultrastructural changes occurring in the bursa of Fabricius of 3 and 7 d old chickens after adriamycin treatment are described. Male Hubbard chickens 7 d old, were injected with a intraperitoneal injection of adriamycin (5 mg/kg/die). All chickens were killed 24 h after the last injection, and the bursa was rapidly excised and fixed immediately for scanning electron microscopy and for transmission electron microscopy. The bursa underwent atrophy and showed epithelium desquamation. After 6 d treatment the dysepithelization was evident. Consequently follicles were made up mostly with large polyedric cells.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002645:Chickens; D004317:Doxorubicin / Q000494:pharmacology*; D008214:Lymphocytes; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008871:Microvilli / Q000648:ultrastructure
chemical_list: D004317:Doxorubicin