Mouse trophoblast cells are constitutive producers of thromboplastin (factor III) in vitro.
Trophoblasts from murine placenta synthesize thromboplastin in the absence of inducing agents and a functional complement system, nor is the rate or level of synthesis enhanced by inducers. A serum factor which is destroyed/removed by addition of oxalate and subsequent dialysis appears to enhance the ability of trophoblasts to synthesize thromboplastin.
D000818:Animals; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism; D008744:Methylamines / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D013925:Thromboplastin / Q000096:biosynthesis* / Q000378:metabolism; D013997:Time Factors; D014327:Trophoblasts / Q000032:analysis / Q000166:cytology / Q000378:metabolism*
D008744:Methylamines; D003165:Complement System Proteins; D013925:Thromboplastin; C027451:methylamine