[Experimental arrhythmia and its prevention].
The preventive antiarrhythmic effect of a new derivative of selenium-containing aralkyl amines, i. e. selenofen-24, was compared with the routinely used drugs-novocainamide, isoptin and inderal. With respect to the preventive effect and spectrum of action selenofen-24 was shown to be advantageous on various experimental models of arrhythmias: aconitine, strophanthin, pituitrin or calcium chloride.
D000588:Amines / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D011342:Procainamide / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D012643:Selenium / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
D000588:Amines; D000889:Anti-Arrhythmia Agents; D011433:Propranolol; D014700:Verapamil; D012643:Selenium; D011342:Procainamide
Eksperimental'naia aritmiia i ee profilaktika.