Secretory IgA in urinary tract infections.
Secretory IgA, measured by radial immunodiffusion, was compared in the urine of children with chronic and recurrent non-obstructive urinary tract infections with that in normal children. IgA, IgG, and IgM were also measured. Absent and low levels of IgA(s) were found in both groups; however, the mean levels of IgA(s) were significantly higher in the infected group compared with normals-3.3 to 0.78 mg./24 hours, respectively. Secretory IgA was found to be locally produced in the bladder. It is suggested that IgA(s) levels reflect an antibody response to infection.
D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000652:urine; D007075:Immunoglobulin M / Q000652:urine; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D001743:Urinary Bladder / Q000378:metabolism; D014552:Urinary Tract Infections / Q000276:immunology*; D005719:gamma-Globulins / Q000378:metabolism* / Q000652:urine
D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins