Transplantation of embryonic chick spinal cord into transection adult chicken spinal cords: a useful model for transplantation research.
Adult chicken spinal cords were completely transected under direct visualization. One week later, embryonic chick spinal cords 6 days, 9 days, or 11 days old were implanted into the site of transection. The animals were allowed to survive for 2 months and then killed and the spinal cords were prepared for histologic analysis. The survival and outgrowth of the embryonic transplants were compared with regard to the age of the implant, and its effects on the host tissue. Six-day embryonic tissue survived and integrated far better than 9-day or 11-day, and adult spinal cord subjacent to the early age embryo showed fewer degenerative changes. The chick embryo may provide a model for use in CNS transplantation.
D000375:Aging; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D006085:Graft Survival; D008954:Models, Biological; D009409:Nerve Crush; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology / Q000637:transplantation; D013116:Spinal Cord / Q000502:physiology / Q000637:transplantation*