The relationship of lithium-potassium cotransport and the passive lithium leak to hypertension in Utah subjects.
Rate constants for lithium-potassium cotransport (kLPC) and the lithium efflux into MgCl2 with furosemide (passive lithium leak) along with sodium-lithium countertransport (SLC) were measured in erythrocytes from 351 normotensive adults age 18 and over, 220 youth under age 18 and in 27 hypertensives. The kLPC was significantly higher in the hypertensives than the adult normotensives with means and standard deviations of 13.9 +/- 9.2 vs. 8.7 +/- 5.9 10(-3)/hr (p less than 0.01). Adjusting for the significant weight (p = 0.014) and sex (p = 0.066, normotensive males higher than females) associations with kLPC in an analysis of covariance, increased the significant difference between the hypertensives and normotensives (p = 0.0004). The passive lithium leak rate constant was also higher in hypertensives than normotensives (20.2 +/- 7.6 vs. 15.5 +/- 5.3 10(-3)/hr, p less than 0.01). Weight (p=0.0003), but not sex, was related to the leak but did not account for the difference between hypertensives and normotensives (p = 0.0009). Mean blood pressure was positively associated with the lithium leak but not the kLPC or SLC values in a multivariate regression.
D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000378:metabolism*; D008094:Lithium / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D015636:Magnesium Chloride; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D015636:Magnesium Chloride; D008094:Lithium; D012964:Sodium; D008274:Magnesium; D011188:Potassium