[Specificity of cytochrome P-450 isoforms contained in endoplasmic reticulum membranes and nuclear membranes in relation to benzo(a)pyrene].
The metabolic activation of benz(a)pyrene (BP) catalyzed by rat liver microsomes and isolated liver nuclei in the presence of certain inhibitors of the monooxygenase system was studied. Several forms of cytochrome P-450 are supposed to participate in metabolic conversion of BP. The specificity of cytochrome P-450 isoforms contained in the endoplasmic reticulum and in nuclear membranes is discussed.
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism*; D001580:Benzopyrenes / Q000378:metabolism; D002384:Catalysis; D002467:Cell Nucleus / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004101:Dihydroxydihydrobenzopyrenes; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D004790:Enzyme Induction / Q000187:drug effects; D007425:Intracellular Membranes / Q000201:enzymology*; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity / Q000187:drug effects
D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; D007527:Isoenzymes; C017228:benzo(a)pyrene 7,8-dihydrodiol; C015813:4,5-dihydroxy-4,5-dihydrobenzo(a)pyrene; D001564:Benzo(a)pyrene; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Spetsifichnost' izoform tsitokhroma P-450, soderzhashchikhsia v membranakh éndoplazmaticheskogo retikuluma i iadernykh membranakh, po otnosheniiu k benz(a)pirenu.