[Correlation between DNA repair synthesis and number of cells with micronuclei during gamma-irradiation of human peripheral blood lymphocytes stimulated and not stimulated with PHA].
The method of colony chromatography on BND-cellulose was used to study DNA repair synthesis (RS) after gamma-irradiation in PHA-stimulated and nonstimulated lymphocytes. The injury to lymphocytes at the cellular level was estimated by the micronuclear test. The comparison of the data on the rate of RS and the number of cells with micronuclei showed that RS inhibition, in the case of the postirradiation treatment of cells with arabinoside cytosine, leads to a decrease in viability of lymphocyte populations, the G0 cells being primarily damaged.
D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000528:radiation effects*; D010835:Phytohemagglutinins / Q000494:pharmacology
D003037:Cobalt Radioisotopes; D010835:Phytohemagglutinins
Korreliatsiia reparativnogo sinteza DNK i chastoty kletok s mikroiadrami pri gamma-obluchenii stimulirovannykh i ne stimulirovannykh FGA limfotsitov perifericheskoĭ krovi cheloveka.