title: Myxoma of the nerve sheath. Report of three cases, observations by light and electron microscopy and histochemical analysis.
abstract: Findings by light and electron microscopy and histochemistry in three cases of myxoma of a nerve sheath are presented. The histochemical findings are compared with those obtained in identical studies done on two benign schwannomas, two neurofibromas, and a soft tissue myxoma. In addition, myxomatous changes in a peripheral nerve obtained at vagotomy were similarly studied. Morphologically, myxoma of the nerve sheath is a distinct neoplastic entity showing moderate cellular atypia and a characteristic tissue distribution. Histochemically, the neoplasm shows a mucopolysaccharide profile that categorizes it as a neoplasm of mesenchymal origin rich in highly sulfated acid mucins. Of particular note is its close histochemical similarity to a neurofibroma.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009232:Myxoma / Q000473:pathology* / Q000648:ultrastructure; D009423:Nervous System Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D012867:Skin / Q000294:innervation / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure