title: Recent changes in serological markers of hepatitis B virus infection in Japanese university students.
abstract: University students were screened for serological markers of hepatitis B virus infection every year. Hepatitis B surface antigen (HBsAg) determined by reversed passive hemagglutination and antibody to HBsAg (anti-HBs) by passive hemagglutination were positive in 1.7% and 7.3% of the first-year students in 1978-80, respectively, and 1.1% and 3.8% in 1981-84. The difference in the prevalences of anti-HBs between 1978-80 and 1981-84 was statistically significant (p less than 0.001). Hepatitis B e antigen, which was positive by less sensitive immunodiffusion in 52% of HBsAg carrier students in 1976-79, was detected by more sensitive radioimmunoassay only in 19% in 1980-84. The difference was statistically significant (p less than 0.01). Recently changes in hepatitis B virus infection seem to be occurring in Japanese university students.
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis*; D006801:Humans; D007564:Japan; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens