Isolation and characterization of butanol-resistant mutants of Clostridium acetobutylicum.
In a wild-type strain of Clostridium acetobutylicum isolated from soil, solvent production appeared limited by butanol toxicity. Butanol-resistant mutants have been obtained which produced significantly higher solvent concentrations (about 30%) than the wild-type strain. Some other physiological differences were observed between a selected resistant mutant and the wild-type strain at the level of solvent resistance and sporulation.
D000440:Butanols / Q000494:pharmacology*; D003013:Clostridium / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D003470:Culture Media; D004352:Drug Resistance, Microbial; D007700:Kinetics; D009154:Mutation; D013045:Species Specificity; D013171:Spores, Bacterial / Q000502:physiology
D000440:Butanols; D003470:Culture Media