Excretion of doxepin and N-desmethyldoxepin in human milk.
Doxepin and N-desmethyldoxepin concentrations in plasma and breast milk from a lactating mother and in plasma from her infant were measured during an 8 week period using high performance liquid chromatography. Plasma concentrations ranged from 35-68 microgram l-1 for doxepin and 65-131 microgram l-1 for N-desmethyldoxepin. Mean pre-feed milk/plasma ratios were 1.08 and 1.02 for doxepin and N-desmethyldoxepin respectively and increased to 1.66 and 1.53 at the post-feed samples. Only N-desmethyldoxepin (15 microgram l-1) was detectable in the infant's plasma sampled after 43 days of maternal therapy.
D000328:Adult; D001942:Breast Feeding; D003866:Depressive Disorder / Q000188:drug therapy; D004316:Doxepin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000378:metabolism*
D004316:Doxepin; C028701:desmethyldoxepin