Anthelmintic efficacy of flubendazole paste against nematodes and cestodes in dogs and cats.
Small dogs and cats, naturally infected with nematodes and cestodes, were used in a critical test under laboratory conditions to determine the palatability and efficacy of flubendazole as a past formulation. Subsequently, a control test in dogs was conducted under field conditions. A 4.4% past formulation was given at a dosage of 22 mg/kg of body weight once a day for 2 or 3 consecutive days. In a critical test in dogs, the efficacy against Toxocara canis was 97.4% after a 2-day administration and 100% after 3 days. Toxascaris leonina seemed to be the most susceptible worm species, since either 2 or 3 treatments were 100% active. The efficacy against Uncinaria stenocephala was 97.5% after 2 treatments; the same dose level for 3 days improved the efficacy to 100%. The efficacy was 100% for the removal of Trichuris vulpis after a daily dosage for 2 days and 96.7% after 3 days. One of 2 dogs infected with Taenia pisiformis was cleared of the infection after a 2-day treatment, and 3 of 4 dogs were cleared after a 3-day regimen. All cats were cleared of Toxocara cati after 2 or 3 days of treatment. One of 2 cats infected with Hydatigera taeniaeformis was cleared of the infection after a 2-day treatment; a 3-day treatment in 7 cats was 100% effective. The results in the laboratory test in dogs were confirmed under field conditions by a control test, based on the reduction of eggs per gram of feces count after treatment. The paste formulation was well accepted by all dogs and cats without any side effects.
D000284:Administration, Oral; D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage; D000969:Antinematodal Agents / Q000008:administration & dosage; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009824:Ointments
D000923:Anticestodal Agents; D000969:Antinematodal Agents; D009824:Ointments; D008463:Mebendazole; C018945:flubendazole