title: Some effects of mucopolysaccharide stains on platelet aggregation.
abstract: FIVE MUCOPOLYSACCHARIDE STAINS INHIBIT PLATELET AGGREGATION INDUCED BY SEVERAL AGGREGATING AGENTS: with two stains inhibition is competitive. Alcian blue, 0.05 mg/ml, added to platelet-rich plasma potentiates ADP-induced aggregation. Alcian blue, 0.5 mg/ml, itself produces platelet aggregation, probably causing the release reaction. Three of these stains produce aggregation of red cells. They also bind heparin, and so may influence heparin-neutralizing sites (platelet factor 4) and probably the charge on the platelet membrane. The only known common factor to these stains is their ability to bind onto the mucopoly-saccharides. It is suggested that when platelets are ;stained' the surface mucopolysaccharide is altered and that this alteration can influence platelet aggregation.
mesh_terms: D001665:Binding Sites; D001792:Blood Platelets / Q000187:drug effects*; D003864:Depression, Chemical; D004912:Erythrocytes / Q000187:drug effects; D006025:Glycosaminoglycans; D006494:Heparin Antagonists; D006801:Humans; D066298:In Vitro Techniques; D007811:Lanthanum / Q000494:pharmacology; D010973:Platelet Adhesiveness / Q000187:drug effects; D012428:Ruthenium / Q000494:pharmacology; D013194:Staining and Labeling
chemical_list: D006025:Glycosaminoglycans; D006494:Heparin Antagonists; D007811:Lanthanum; D012428:Ruthenium