title: Stereoselective disposition of indoprofen in surgical patients.
abstract: The pharmacokinetics of the enantiomers of indoprofen were determined after intravenous administration of the racemate to 10 surgical patients. The mean volume of distribution was 8.97 +/- 2.21 (s.d.) 1 for the pharmacologically active S(+)-enantiomer and 12.60 +/- 4.21 1 for the R(-)-enantiomer (P less than 0.001). The corresponding values for clearance were 32.2 +/- 11.1 ml min-1 and 48.8 +/- 15.5 ml min-1 (P less than 0.001). There was no significant difference in mean terminal half-life between the enantiomers.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006801:Humans; D007216:Indoprofen / Q000097:blood*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000097:blood*; D011184:Postoperative Period; D013237:Stereoisomerism
chemical_list: D010666:Phenylpropionates; D007216:Indoprofen