title: The effect of chrysene and some polycyclic aromatic hydrocarbons on the elimination of theophylline in rats.
abstract: The investigations of the effect of some compounds belonging to the group of polycyclic aromatic hydrocarbons (PAH), e. g. benzo[a]pyrene, chrysene, fluorene and pyrene, on the elimination of theophylline injected i. v. into rats have shown that benzo[a]pyrene and chrysene accelerate the elimination of this drug (elimination rate constant in control group: 0.2504 h-1; after benzo[a]pyrene: 0.3626 h-1; after chrysene: 0.3582 h-1). The increase of theophylline elimination rate constant by chrysene depends on its dose, and this relationship is of sigmoid type in the dose range of 1-20 mg X kg-1. Besides, dependence of theophylline elimination rate constant on the time of chrysene dosing was also shown. After oral administration of theophylline the decrease of its amount reaching the circulation by 11% was also observed, which was caused by the influence of chrysene on the first-pass effect, beside its influence on the elimination rate.
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage; D001682:Biological Availability; D002911:Chrysenes / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010616:Phenanthrenes / Q000008:administration & dosage*; D011721:Pyrenes / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000378:metabolism*
chemical_list: D002911:Chrysenes; D005449:Fluorenes; D010616:Phenanthrenes; D011721:Pyrenes; C031180:chrysene; D001564:Benzo(a)pyrene; C041509:fluorene; C030984:pyrene; D013806:Theophylline