Hymenolepis microstoma: histopathological changes in mice maintained at different environmental temperatures.
Livers of uninfected mice maintained at 5 C did not differ histologically from mice kept at 21 C, but the hepatocytes of mice kept at 35 C were depleted of glycogen. Regardless of temperature, infection with a single Hymenolepis microstoma induced inflammatory changes in the livers of all mice. However, the degree of histopathology was less in mice kept at 21 C than in mice at 5 C or 35 C. Infected mice in the hot and cold environments developed necrotic lesions in their liver parenchyma. Livers of mice kept at 35 C contained many foreign body giant cells. Temperature had no histological effect on the common bile duct, but in all infected mice there was a pronounced thickening of the bile duct wall due to intensive infiltration of the submucosa with fibrous connective elements and inflammatory leucocytes.
D000818:Animals; D001652:Bile Ducts / Q000473:pathology; D003135:Common Bile Duct / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006925:Hymenolepiasis / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008297:Male; D051379:Mice; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D013696:Temperature