Effect of Fluosol-DA (20%) on skin flap survival in rats.
This study evaluates the effect of increased oxygen-carrying capacity of blood with the oxygen-carrying blood substitute Fluosol-DA (20%) on skin flap survival in rats. A skin flap model as described by Finseth was used in male Sprague-Dawley rats. We found that Fluosol-DA (20%) alone or in conjunction with O2 does not augment survival of skin flaps in rats, while hemodilution enhances and hemoconcentration deteriorates skin flap survival. Systemic O2 does not enhance survival of skin flaps in rats.
D000818:Animals; D001802:Blood Substitutes / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects; D004338:Drug Combinations / Q000627:therapeutic use; D005466:Fluorocarbons / Q000627:therapeutic use*; D006085:Graft Survival / Q000187:drug effects; D006400:Hematocrit; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D009336:Necrosis / Q000517:prevention & control*; D010100:Oxygen / Q000378:metabolism / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen