Antitumor activity of bovine cartilage extract (Catrix-S) in the human tumor stem cell assay.
Catrix is an acidic mucopolysaccharide complex derived from bovine tracheal cartilage. The antitumor efficacy of Catrix has been evaluated in the human tumor stem cell assay system using three human tumor cell lines and fresh biopsy specimens from 22 patients with malignant tumors. In vitro efficacy has been demonstrated with high dose continuous exposure Catrix, particularly against the 8226 human myeloma cell line as well as ovarian, pancreatic, colon, testicular, and sarcoma biopsy specimens. The level of sensitivity was at less than or equal to 30% survival of colony growth in vitro. Since the in vitro concentrations may be achievable in vivo, the results justify more detailed in vitro evaluation as well as potential clinical trials.
D000970:Antineoplastic Agents; D001943:Breast Neoplasms / Q000188:drug therapy; D002460:Cell Line; D003110:Colonic Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D014020:Tissue Extracts / Q000494:pharmacology*; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D014020:Tissue Extracts; C006931:bovine cartilage extract