title: Increased clearance rate of plasma thyroxine accompanies estradiol-induced vitellogenesis in male Japanese quail.
abstract: Four days after giving 16 mumol estradiol-17 beta (E2) per 100 g body weight to male Japanese quail, the thyroids of these quail accumulated twice as much 125I as did the thyroids of control quail. Plasma thyroxine concentrations were 7.38 +/- 45 (SE) ng/ml (n = 16) for the E2-treated quail and 3.38 +/- .53 ng/ml (n = 16) for the controls. Clearance rates of plasma thyroxine were 534 ng thyroxine/100 g/day for the E2-treated quail and 234 ng/100 g/day for the control quail. The E2 may have increased the metabolism of thyroxine in these male quail and, by inference, stimulated a twofold increase in the rate of synthesis and secretion of thyroxine.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003370:Coturnix / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D011784:Quail / Q000502:physiology*; D013974:Thyroxine / Q000097:blood*; D014818:Vitellogenesis / Q000187:drug effects*
chemical_list: D004958:Estradiol; D013974:Thyroxine