[Thiamine pyrophosphate-dependent enzymes in the regenerating liver of albino rats under different regimens of oxythiamine administration].
Activities of the thiamine pyrophosphate-dependent enzymes (pyruvate dehydrogenase, oxoglutarate dehydrogenase, transketolase) were increased in regenerating rat liver tissue as compared with their activities in the intact tissue. After administration of oxythiamine (20 mg/kg, within 10 days, subcutaneously) into the animals the enzymatic activity studied was decreased.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D010119:Oxythiamine / Q000008:administration & dosage / Q000494:pharmacology*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D051381:Rats; D013832:Thiamine Deficiency / Q000201:enzymology; D013835:Thiamine Pyrophosphate / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors
D011768:Pyruvate Dehydrogenase Complex; D013844:Thiazoles; D010119:Oxythiamine; D007655:Ketoglutarate Dehydrogenase Complex; D014174:Transketolase; D013835:Thiamine Pyrophosphate
Aktivnost' tiaminpirofosfatsoderzhashchikh fermentov v regeneriruiushcheĭ pecheni belykh krys pri razlichnykh rezhimakh vvedeniia oksitiamina.