[The influence of pipemidic acid on epinephrine and collagen induced platelet aggregation in vitro].
Concentrations of pipemidic acid (Deblaston) similar to maximal levels obtained in the serum of patients with intact renal function after application of therapeutic doses do not influence epinephrine (adrenaline)- or collagen-induced aggregation in vitro. With 20 micrograms/ml pipemidic acid, corresponding 4- to 5-fold maximal serum levels epinephrine-induced aggregation is reduced significantly, while aggregation by collagen is not affected. A significant reduction of epinephrine-induced aggregation as well as of collagen-induced aggregation is brought about only with doses of pipemidic acid as high as 100 micrograms/ml. But these changes still occur within the normal range. Therefore we conclude from our study, that platelet aggregation is not affected in a clinically relevant manner by pipemidic acid.
D000328:Adult; D003094:Collagen / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D010876:Pipemidic Acid / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*
D009539:Nicotinic Acids; D003094:Collagen; D010876:Pipemidic Acid; D004837:Epinephrine
Untersuchungen zum Einfluss von Pipemidsäure auf die durch Epinephrin und Kollagen induzierte Thrombozytenaggregation in vitro.