Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma.
Ultrafiltrate and total plasma and cerebrospinal fluid (CSF) platinum concentrations were examined in a patient with neuroblastoma following a 2-hour infusion of 120 mg/m2 of cisplatin. Total plasma platinum was 93.4% bound, while the ultrafiltrate of plasma accounted for the remaining 6.6%. The CSF ultrafiltrate resulted in equivalent concentrations of platinum to total CSF platinum. CSF concentrations were 2.9% of the total plasma platinum and 43.5% of the ultrafiltrate plasma platinum 2 hours after the end of the infusion.
D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D002675:Child, Preschool; D002945:Cisplatin / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000378:metabolism*; D010984:Platinum / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D013997:Time Factors; D014462:Ultrafiltration
D010984:Platinum; D002945:Cisplatin