title: Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides.
abstract: Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and protein-bound thiols) in these cells. Such changes were also recorded in erythrocytes exposed to 4,4'-diaminodiphenyl disulphide, 2,2'-diaminodiphenyl disulphide, 4,4'-dimethyldiphenyl disulphide, 4,4'-dinitrodiphenyl disulphide, diphenyl disulphide-2,2'-dicarboxylic acid and dibenzyl disulphide. The relative potency of these compounds in causing erythrocyte damage is correlated with their ability to generate 'active oxygen' species in vitro.
mesh_terms: D000818:Animals; D004220:Disulfides / Q000633:toxicity*; D004912:Erythrocytes / Q000378:metabolism*; D006366:Heinz Bodies / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000097:blood*; D066298:In Vitro Techniques; D008706:Methemoglobin / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004220:Disulfides; D006454:Hemoglobins; D008706:Methemoglobin; D006861:Hydrogen Peroxide