Enterohepatic recycling of N-nitrosodiethanolamine in rats.
N-Nitrosodiethanolamine (NDELA) was administered to rats whose bile was drained directly into the duodenum of a second group of animals, in which the natural bile flow was ligated, thus simulating enterohepatic circulation. The presence of NDELA and its metabolite N-(2-hydroxyethyl)-N-(carboxymethyl)nitrosamine in the urine of the 'bile-recipient' rats indicated that NDELA was first excreted into the bile and then reabsorbed from the duodenum into the bloodstream. The enterohepatic recycling of NDELA may be a factor in the compound's known hepatocarcinogenicity.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000031:analogs & derivatives* / Q000378:metabolism; D004764:Enterohepatic Circulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; C014129:N-nitrosodiethanolamine; D004052:Diethylnitrosamine