title: Frequency-dependent effect of verapamil on rat soleus muscle.
abstract: In the presence of verapamil (0.1 mM) rat soleus muscle fibers failed to generate action potentials with overshoots. In fibers with their Vm set to a local level of -90 mV, verapamil produces a gradual reduction in the amplitude of the repetitive action potentials; this effect is more pronounced at high rates of stimulation (100 Hz). Our results suggest a local anesthetic action of this drug that could contribute with its calcium channel blocking effect to the diminished mechanical tension observed in the presence of the drug.
mesh_terms: D000200:Action Potentials / Q000187:drug effects*; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004558:Electric Stimulation; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013314:Stress, Mechanical; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D002121:Calcium Channel Blockers; D014700:Verapamil