Corticosteroid therapy in biliary atresia.
Sixteen patients with biliary atresia had 44 steroid courses for treatment of cholangitis or diminution of bile flow following Kasai hepatic portoenterostomy operations. A "blast" type (high dose/short duration) steroid administration was employed to potentiate the choleretic and anti-inflammatory effect. There was a significant augmentation of bile flow and a reduction in maximum temperature, serum bilirubin, and alkaline phosphatase.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001646:Bile / Q000378:metabolism; D001652:Bile Ducts / Q000002:abnormalities*; D001663:Bilirubin / Q000097:blood; D002675:Child, Preschool; D002761:Cholangitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D008722:Methods
D000305:Adrenal Cortex Hormones; D001663:Bilirubin