N-Glucosidation of amobarbital in the cat.
N-Glucosidation is a novel pathway of barbiturate metabolism, so far known to occur only in man. A search for an animal model, conducted through in vitro screening, revealed that amobarbital-N-glucoside was formed in liver preparations from the cat. The presence of amobarbital-N-glucoside was demonstrated in cat urine, following i.p. administration of amobarbital.
D000654:Amobarbital / Q000378:metabolism* / Q000652:urine; D000818:Animals; D002415:Cats; D005243:Feces / Q000032:analysis; D005260:Female; D006027:Glycosides / Q000378:metabolism* / Q000652:urine; D006801:Humans; D066298:In Vitro Techniques; D007420:Intestine, Large / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D013045:Species Specificity
D006027:Glycosides; D000654:Amobarbital