Reversal of sulfide-induced effects on porphyrin metabolism by exogenous heme.
Rats injected intraperitoneally with 0.15 mmol sodium sulfide/kg body weight showed decreased reticulocyte delta-aminolevulinic acid synthase and heme synthase activities 24 h later. Liver delta-aminolevulinic acid synthase and heme oxygenase activities were also decreased at the same time. Injection of heme arginate (10 mg heme/kg body weight) intraperitoneally 3 h after the sulfide dose completely corrected the sulfide effects and greatly stimulated the hepatic heme oxygenase activity.
D000624:5-Aminolevulinate Synthetase / Q000037:antagonists & inhibitors; D000818:Animals; D005294:Ferrochelatase / Q000037:antagonists & inhibitors; D006418:Heme / Q000494:pharmacology*; D008297:Male; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000201:enzymology; D013440:Sulfides / Q000037:antagonists & inhibitors*
D011166:Porphyrins; D013440:Sulfides; D006418:Heme; D000624:5-Aminolevulinate Synthetase; D005294:Ferrochelatase