Decreased gelatin-binding fibronectin in patients with chronic inflammatory bowel diseases.
The plasma fibronectin concentration (PF) was measured in 48 patients with chronic inflammatory bowel disease (CIBD) and in 48 age- and sex-matched healthy controls, using electroimmunoassay and a functional (gelatin-binding) assay. Whereas no difference in immunochemically measured PF was found between the two groups, patients with CIBD had significantly lower gelatin-binding PF than healthy controls (p less than 0.001). Immunochemically measured PF increased, whereas functionally measured PF tended to decrease with increasing disease activity.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000097:blood*; D003424:Crohn Disease / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D005780:Gelatin; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged
D005353:Fibronectins; D005780:Gelatin