Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia.
Antipyrine salivary clearance and half-life and the rate of formation of three principal metabolites of antipyrine (4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norantipyrine) were assessed in nine children with congenital adrenal hyperplasia, six of whom were salt-losers and three of whom were non-salt-losers. No differences were found in comparison with data obtained in normal children.
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000201:enzymology / Q000378:metabolism*; D000983:Antipyrine / Q000378:metabolism*; D001711:Biotransformation; D002648:Child; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003647:Debrisoquin / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate
D003577:Cytochrome P-450 Enzyme System; D000983:Antipyrine; D003647:Debrisoquin