Physico-chemical and biological properties of actagardine and some acid hydrolysis products.
Actagardine (originally designated as metabolite B or gardimycin) is a polypeptide antibiotic produced by fermentation of Actinoplanes strains ATCC 31048 and 31049. During the course of repeated fermentations two new compounds, coded D and E, were isolated. Some physico-chemical and biological characteristics of actagardine and of both compounds are presented. Compound D is derived from chemical transformation of actagardine.
D000818:Animals; D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D051379:Mice; D010455:Peptides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D010455:Peptides; C012993:gardimycin