Pharmacokinetics and dosage requirements of netilmicin in cystic fibrosis patients.
The pharmacokinetics of netilmicin were determined in 10 patients with cystic fibrosis. Mean (+/- standard error of the mean) values for total body clearance and volume of distribution were 2.62 (+/- 0.18) ml/min per kg of body weight and 0.38 (+/- 0.01) liter/kg, respectively, and were considerably larger than the same parameters reported for patients without cystic fibrosis.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D009428:Netilmicin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000209:etiology
D009428:Netilmicin