title: Salt induced conformational transition between A and Z forms of r(CGCGCG) as revealed by a Raman spectroscopic study.
abstract: Solution conformation in different conditions of r(CGCGCG) has been studied by a Raman spectroscopic method. In NaCl solution, r (CGCGCG) takes only an A-form duplex in which guanosine and cytidine have C3'endo-anti conformation even at 5M salt concentration. In much higher ionic strength condition (5M NaCl plus 1M MgCl2 or 6M NaClO4), it undergoes a transition to a left-handed Z-form. The Raman spectrum of the Z-form RNA was found to be very similar to that of Z-form DNA, suggesting that Z-RNA involves a C3'endo-syn guanosine and an in between form of C2'endo-Cl'exo-anti cytidine.
mesh_terms: D007700:Kinetics; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides; D009994:Osmolar Concentration; D012492:Salts; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D009843:Oligoribonucleotides; D012492:Salts