title: The valved conduit prevents ascending cholangitis: a follow-up.
abstract: Reflux of bacteria-laden intestinal contents into the biliary tree can be prevented by an intussuscepted valve in an isolated segment of jejunum interposed between the porta hepatis and the duodenum. This method of bile duct reconstruction was adopted in 1979 and since then has been used in 17 children with biliary atresia and 9 with choledochal duct cysts. Those with choledochal duct cysts are well. Follow-up HIDA scans demonstrate normal bile flow, and ultrasound examinations have not revealed dilated bile ducts. Bile flow was established in 13 infants with biliary atresia and was persistent in 8. Two expired because of unrelated problems between 2 to 6 months postoperatively. One of these children developed cholangitis, but at autopsy the nipple valve was incompetent. Six children currently have normal serum bilirubin levels and are clinically well. The average postoperative stay for these patients was 7.5 days. Three were rehospitalized for brief periods for suspected cholangitis which was not proven. Bile flow was never established in 4 babies and was present only briefly in 5. Five of these children died of progressive liver failure and one from unrelated causes. Two have had liver transplants, and a third is awaiting transplantation.
mesh_terms: D001646:Bile / Q000378:metabolism; D001652:Bile Ducts / Q000002:abnormalities*; D001663:Bilirubin / Q000097:blood; D002761:Cholangitis / Q000209:etiology / Q000517:prevention & control*; D003137:Common Bile Duct Diseases / Q000601:surgery*; D003560:Cysts / Q000601:surgery*; D004322:Drainage / Q000379:methods; D004386:Duodenum / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007583:Jejunum / Q000601:surgery*; D008297:Male; D008722:Methods; D011168:Portal System / Q000601:surgery*
chemical_list: D001663:Bilirubin