[Gas exchange and metabolic functions of the lungs in endotoxic shock].
The experiments were carried out in 27 dogs with endotoxic shock under conditions of the artificial ventilation of the lungs and barbital anesthesia. It was established that under the above conditions the metabolic functions of the lungs were the first to be impaired. The artificial ventilation of the lungs fails to prevent the development of the impairment of the surfactant-synthesizing function of the lungs as well as the serotonin-inactivating function of the lungs. Two stages of the development of the shock lung syndrome were distinguished: the first one is the disturbance of the metabolic functions of the lungs; the second one is the disturbance of the gas exchange function of the lungs.
D000142:Acidosis, Respiratory / Q000209:etiology; D000818:Animals; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000209:etiology; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011659:Pulmonary Gas Exchange; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012131:Respiratory Insufficiency / Q000209:etiology; D012701:Serotonin / Q000378:metabolism*; D012772:Shock, Septic / Q000503:physiopathology*
D007773:Lactates; D011773:Pyruvates; D012701:Serotonin; D019344:Lactic Acid; D019289:Pyruvic Acid
Gazoobmennye i metabolicheskie funktsii legkikh pri endotoksinovom shoke.