title: Acetaldehyde and morphine interaction in the preexposure conditioned taste aversion paradigm in the rat.
abstract: The interaction between acetaldehyde, the primary metabolite of ethanol, and morphine was examined in the preexposure conditioned taste aversion (CTA) paradigm. Rats that were preexposed to acetaldehyde did not display a CTA to morphine. While acetaldehyde at the dose tested did not induce a strong CTA, morphine preexposure, however, reversed the decrease in saccharin associated with acetaldehyde injection thus reflecting a symmetrical interaction between acetaldehyde and morphine. Implications for a mechanism of ethanol-opiates interaction are discussed.
mesh_terms: D000079:Acetaldehyde / Q000008:administration & dosage*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012201:Reward; D012439:Saccharin; D013649:Taste / Q000187:drug effects*
chemical_list: D000431:Ethanol; D009020:Morphine; D012439:Saccharin; D000079:Acetaldehyde