How does the Pivka inhibitor interfere with the one-stage prothrombin time?
Thromboplastins which were highly (Thrombotest) and slightly (Normotest) sensitive to the Pivka (protein induced by vitamin K absence) inhibitor were selected in this study. The influence of the Pivka inhibitor increased with increasing sample size and decreasing packed cell volume; however, a satisfactory correction for the Pivka inhibitor was possible. The inhibitor explained the different coagulation activities in the various assays and also interfered with the ratio method of standardization.
D015415:Biomarkers; D001777:Blood Coagulation / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D011498:Protein Precursors / Q000494:pharmacology*; D011516:Prothrombin / Q000494:pharmacology*; D011517:Prothrombin Time; D012015:Reference Standards; D013925:Thromboplastin / Q000037:antagonists & inhibitors
D015415:Biomarkers; D011498:Protein Precursors; C008208:acarboxyprothrombin; D011516:Prothrombin; D013925:Thromboplastin