Estrogen-induced increase in eosinophil number and peroxidase activity in uterus of genetically mast cell-deficient W/Wv mice.
The role of mast cells in induction of uterine eosinophilia was investigated by using genetically mast cell-deficient (WB X C57BL/6)F1-W/Wv (hereafter called WBB6F1-W/Wv) mice. The injection of estradiol-17 beta (0.16 micrograms/g body weight) increased the peroxidase activity and eosinophil number in the uteri of castrated WBB6F1-W/Wv and WBB6F1-+/+ mice. Since no significant differences were detectable between these two type of mice, mast cells did not seem to be essential for the estrogen-induced uterine eosinophilia, at least in mice.
D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology; D004804:Eosinophils / Q000166:cytology* / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008407:Mast Cells / Q000166:cytology*; D051379:Mice; D008817:Mice, Mutant Strains; D010052:Ovariectomy; D010544:Peroxidases / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D004958:Estradiol; D004155:Diphenhydramine; D010544:Peroxidases