Inhaled ketotifen in exercise-induced asthma--a negative report.
The effects of 2 concentrations of inhaled ketotifen (0.25 g/l and 0.5 g/l) were compared with saline in 7 extrinsic asthmatics with exercise induced asthma (EIA). Inhaled ketotifen produced bronchodilatation with a significant increase of 15.4% on mean baseline FEV1 at the higher concentration (p less than 0.05). After exercise the mean percentage fall in FEV1 was 38.4% in the saline group, with no significant difference in the ketotifen pretreated groups, although 2 patients did not have EIA after inhalation of either ketotifen concentrations.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007665:Ketotifen / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012119:Respiration; D013997:Time Factors
D007665:Ketotifen