Brain adenylate cyclase activity in the amphetamine sensitized rat.
Behaviour was augmented in rats by treatment with 10 mg/kgm d-amphetamine twice a day for 10 days. A greater activation of adenylate cyclase was found in dopamine rich areas of these rats brains than in normal controls when the enzyme was tested with sodium fluoride and quanylimidodiphosphate. These results parallel similar findings in the brains of schizophrenics obtained at post mortem and support the use of amphetamine sensitization in rats as a model for schizophrenia.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003342:Corpus Striatum / Q000201:enzymology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008032:Limbic System / Q000201:enzymology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology; D013997:Time Factors
D006165:Guanylyl Imidodiphosphate; D012969:Sodium Fluoride; D000661:Amphetamine; D000262:Adenylyl Cyclases