Yohimbine hydrochloride as an antagonist to xylazine hydrochloride-ketamine hydrochloride immobilization of white-tailed deer.
Thirteen captive and one free-ranging white-tailed deer (Odocoileus virginianus) were immobilized one to six times each with ketamine hydrochloride and xylazine hydrochloride during winter and spring in northern Minnesota. Administration of 0.09 to 0.53 mg of yohimbine hydrochloride per kg IV after each trial reversed the immobilization. The deer raised their heads within a median time of 2.0 min, stood in 6.0 min and walked away in 9.5 min. No adverse side effects were observed for several weeks following the immobilization.
D000818:Animals; D000835:Animals, Wild; D001831:Body Temperature / Q000187:drug effects; D003670:Deer; D004338:Drug Combinations; D007103:Immobilization; D007649:Ketamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D013843:Thiazines / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014991:Xylazine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D015016:Yohimbine / Q000494:pharmacology*
D004338:Drug Combinations; D013843:Thiazines; D014991:Xylazine; D015016:Yohimbine; D007649:Ketamine