Microsurgical application of freeze-dried venous allografts.
Freeze-dried venous interposition allografts with an internal diameter of 1.0 mm and a length of 1.0 cm were placed into the femoral arteries of 17 Sprague-Dawley albino male rats in order to investigate patency and host tissue response. The immediate patency rate was 88%. The epigastric island flap was monitored as a sign of patency in the early postoperative period (defined as 1 to 3 days). Twelve of the 17 subjects were observed for 2 months, at which point 66% (8/12) remained patent. There were two aneurysmal dilatations. Histopathological studies and transmission electron microscopy demonstrated that freeze-dried veins undergo complete remodeling in vivo by a normal reparative process and that they do not induce a cellular immune response in the host.
D000005:Abdomen / Q000098:blood supply*; D000818:Animals; D004727:Endothelium / Q000648:ultrastructure; D005263:Femoral Artery / Q000601:surgery*; D005612:Freeze Drying; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000473:pathology; D007111:Immunity, Cellular; D008297:Male; D008866:Microsurgery; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps; D014680:Veins / Q000637:transplantation* / Q000648:ultrastructure; D014945:Wound Healing