Behavioral and neurochemical effects of (-)- and (+/-)-cathinone: dose-response and time-course.
The purpose of the present study was to compare (-)-cathinone and its analogue (+/-)-cathinone using behavioral and neurochemical measures. Rats were trained to discriminate between 0.6 mg/kg (-)- or (+/-)-cathinone and saline in a food-motivated, two-lever operant task. In addition, concentrations of dopamine, norepinephrine, 5-hydroxytryptamine and their major metabolites were analyzed in the nuclei accumbens and septi lateralis. The results suggest that (-)- and (+/-)-cathinone have similar effects on behavior and neurochemistry with (-)-cathinone being more potent.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013997:Time Factors
D000470:Alkaloids; D011619:Psychotropic Drugs; C023665:cathinone