The effects of manipulation of presynaptic 5-HT nerve terminals on postsynaptic 5-HT1 and 5-HT2 binding sites of the rat brain.
The effects of long-term treatment of rats with alaproclate and amiflamine on the number and kinetics of 5-HT1 and 5-HT2 binding sites were investigated using in vitro receptor binding techniques. Some other studies have reported down-regulatory effects of alaproclate and amiflamine on 5-HT2 binding sites in certain regions of the rat forebrain, but no such effects could be detected in the present study. Induction of a high-affinity binding site for 3H-5-HT after long-term antidepressant treatment, as has been reported elsewhere, was not obtained in the present study. The results are compared to the effects obtained by treatment of rats with para-chloroamphetamine (PCA), which depletes the presynaptic neurons of monoamines. These different types of treatment do not cause any change in the binding properties of the specific 5-HT binding sites. It is thus concluded that such manipulations of the presynaptic 5-HT neurons do not affect the postsynaptic 5-HT1 and 5-HT2 binding sites.
D000409:Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D000928:Antidepressive Agents; D010627:Phenethylamines; D012701:Serotonin; D010133:p-Chloroamphetamine; C025293:alaproclate; C031466:amiflamine; D000409:Alanine