[Somatosensory evoked potentials (SEP) by isoflurane and enflurane in cardiosurgical interventions].
In the order to gain further insight into the sensory nervous pathways during enflurane- and isoflurane anaesthesia, two different concentrations (1 and 2 vol.%) of the anaesthetics were given to patients during extracorporeal circulation in normothermia and normocarbia, while somatosensory-evoked potentials (SEP) were recorded. As SEP-changes either reflect a change in functional integrity of the sensory nervous pathways (amplitude suppression) and a change in the speed of conduction (latency changes), the central effects of the volatile anaesthetics could be more fully evaluated. Isoflurane as well as enflurane induced a concentration-related change in latency especially of the late N100-component. However, in contrast to isoflurane administration the isomer enflurane in the high concentration range (2 vol.%) induced an increase of amplitudes of the early N20 and late N100-peak. Such an increase in amplitudes is interpreted as a disinhibition of medullary inhibitory centres, a possible premonitory sign of epileptogenic cortical activity, which already had been observed by various investigators.
D000344:Afferent Pathways / Q000187:drug effects; D000769:Anesthesia, Inhalation; D004737:Enflurane; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006331:Heart Diseases / Q000601:surgery*; D006801:Humans; D007530:Isoflurane; D008475:Median Nerve / Q000187:drug effects; D008738:Methyl Ethers; D011930:Reaction Time / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects
D008738:Methyl Ethers; D004737:Enflurane; D007530:Isoflurane
Somatosensorisch-evozierte Potentiale (SEP) unter Isofluran und Enfluran bei kardiochirurgischen Eingriffen.