Hippocampal variation between the inbred mouse strains C3H/HeJ and DBA/2: a quantitative-genetic analysis.
A classical cross-breeding study involving the inbred mouse strains DBA/2 and C3H/HeJ revealed a rather complex mode of inheritance for the following hippocampal variables: size of stratum pyramidale, number of supra-, intra- and infrapyramidal mossy fiber synapses, and the size of terminal fields receiving entorhinal input. A polygenic mode of inheritance was inferred for these phenotypes. For the size of the regio inferior a model containing additive genetic effects only was sufficient to explain the variation between generations. The strain difference may be caused by one genetic factor only. In agreement with previous experiments a strong negative correlation between the number of intra- and infrapyramidal mossy fiber synapses and shuttle-box avoidance performance was found in the genetically heterogeneous F2 population.
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D005260:Female; D006579:Heterozygote; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000033:anatomy & histology* / Q000502:physiology; D008811:Mice, Inbred DBA / Q000033:anatomy & histology* / Q000502:physiology