title: Synthesis and antiinflammatory activity of 7-oxo-1H,7H-pyrazolo[1,5-a]pyrimidine-6-N-pyridylcarboxamides.
abstract: A series of 7-oxo-1H,7H-pyrazolo[1,5-a]pyrimidine-6-N-pyridylcarboxamides was synthesized and assayed in the carrageenin-induced paw oedema test in the rat. Some compounds showed moderate antiinflammatory activity.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D011743:Pyrimidines; D002351:Carrageenan