Interaction of cis-diamminedichloroplatinum (II) with mitochondrial phosphate carrier.
Effect of cis-Pt(II) on mitochondrial phosphate transport has been studied. The inhibition of transport by cis-Pt(II) is demonstrated by the effect of the drug on mitochondrial phosphate-induced swelling and respiration. A diminished 14C-NEM binding to 33 kD mitochondrial protein in the presence of cis-Pt(II) suggests that cis-Pt(II) inhibits mitochondrial phosphate transport by a direct interaction with mitochondrial phosphate carrier.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D002945:Cisplatin / Q000494:pharmacology*; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008634:Mersalyl / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D028044:Phosphate-Binding Proteins; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002352:Carrier Proteins; D028044:Phosphate-Binding Proteins; D010710:Phosphates; D008634:Mersalyl; D002945:Cisplatin