Synthesis of 2'-end-modified 2'-5'-oligoadenylates.
Analogs of 2'5'-oligiadenylates (2-5As) have been prepared on the basis of the recently developed internucleotide-linkage formation via selective hydroxyl activation of N-unprotected nucleosides. The analogs synthesized include the trimeric cores having 2'-deoxyadenosine, cordycepin (3'-deoxyadenosine), and 2',3'-bisdeoxyadenosine at the 2' termini, and the tetramer with 2'-end 2'-deoxyadenosine.
D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D000241:Adenosine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D000241:Adenosine