title: A histomorphometric analysis of subchondral bone in juvenile arthropathy of the dog knee.
abstract: Subchondral bone changes in arthropathy were investigated in an animal model using mongrel dog knees. Unilateral arthritis of the knee was induced by repeated intra-articular instillations of Carrageenin solution in 14 mongrel puppies. Histomorphometric analysis of cartilage and bone was performed blindly in both knees of each dog. Arthritis resulted in a significant increase in the joint cartilage thickness and a significant decrease in subchondral epiphyseal trabecular bone volume (VTB%) and trabecular thickness (TRTH), suggesting negative bone balance. No significant changes in osteoid surfaces (OS%) and resorptive surfaces (RS%) were found. The dynamic parameters suggest an increased bone turnover in the arthritic subchondral bone.
mesh_terms: D000818:Animals; D001171:Arthritis, Juvenile / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D002356:Cartilage / Q000473:pathology; D004285:Dogs; D007719:Knee Joint / Q000473:pathology; D010012:Osteogenesis; D011453:Prostaglandins / Q000502:physiology
chemical_list: D011453:Prostaglandins