Binaural interactions in cortical area AI of cats reared with unilateral atresia of the external ear canal.
Binaural interactions were recorded in auditory cortical (AI) neurons of anesthetized adult cats that had unilateral atresias created shortly after birth by surgically ligating and cutting one external ear canal. At the time of the recording experiment, the atresia and associated debris were removed and tones were delivered to both tympanic membranes via a sealed and calibrated acoustic system. The majority of neurons recorded were in the cortex ipsilateral to the previously occluded ear. Thresholds for monaural stimulation of either the operated or unoperated ear were within normal range although thresholds to stimulation of the previously operated ear tended to occupy the upper end of the normal distribution. Monotonic and nonmonotonic spike count-vs-intensity functions derived from responses to monaural stimulation of the atretic ear were indistinguishable in their shape from those recorded in normal cats. All binaural classes were represented in our sample in proportions similar to those reported in cats with two normal ears. The forms of the functions relating spike count to interaural intensity differences and interaural phase differences were essentially the same as those seen in normal animals. The main binaural deficit observed under these conditions was a shift in the interaural intensity difference to which an AI neuron was most sensitive. The intensity needed for a stimulus to the atretic ear to participate in the binaural response was as much as 50 dB higher than that at the opposite normal ear in contrast to the nearly equal SPLs required for binaural interactions in cats with two ears intact. It was suggested that elevated thresholds at the previously operated ear could account for much of the shift observed.
D000200:Action Potentials; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001300:Audiometry, Evoked Response; D001303:Auditory Cortex / Q000502:physiology* / Q000503:physiopathology; D001307:Auditory Perception / Q000502:physiology*; D001309:Auditory Threshold; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D007839:Functional Laterality; D034381:Hearing Loss / Q000503:physiopathology*; D006314:Hearing Loss, Conductive / Q000503:physiopathology*; D009473:Neuronal Plasticity