Enhancement of brain pyridoxal 5'-phosphate level following chronic ingestion of ethanol.
The concentrations of pyridoxal 5'-phosphate in the brains of DBA/2J mice during the withdrawal period following chronic ethanol ingestion were measured fluorimetrically. The brain of the ethanol-withdrawn mouse contains 22.4 +/- 3.1% more pyridoxal 5'-phosphate than the brain of a control mouse. The enhanced susceptibility to epileptic seizures during the withdrawal phase may in part be due to the increased cerebral content of this coenzyme.
D000437:Alcoholism / Q000378:metabolism* / Q000523:psychology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004195:Disease Models, Animal; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005470:Fluorometry; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome
D000431:Ethanol; D011732:Pyridoxal Phosphate