The synthesis and biological properties of some 5-substituted-2'-deoxyuridines.
The reaction of various nucleophiles with 5-vinyl-2'-deoxyuridine has been studied in an attempt to explain the in vitro toxicity of the compound. Attempts to synthesise pro-drugs of 5-vinyl- and 5-ethynyl-2'-deoxyuridine are described.
D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; C011381:5-vinyl-2'-deoxyuridine; D003857:Deoxyuridine