[Effect of vasopressin and enkephalin analogs on the chemoreactive properties of the sensorimotor cortex neurons in rats].
On immobile rats it has been shown that subcuteneous injection of two different neuropeptides causes different distribution of activating, inhibiting and areactive cells resulting from microionoforetically administrated acetylcholine and noradrenaline without altering the mean frequency of the background unit activity sensorimotor cortical neurons. At the same time the alteration in the pattern of neurons impulse activity has been revealed, which acquires the character of packet activity with a specific packet length of 2-3, 4-6, 7-10 impulses. Depending on the injected neuropeptide reliable but almost contrary effects of the packet activity alterations have been observed. These effects have been suggested to result from the alteration of the chemoreactive properties of the neuron membranes and the corresponding reorganisations of interneuron attitudes.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004347:Drug Interactions; D004745:Enkephalins / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D007478:Iontophoresis; D009044:Motor Cortex / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats
D004745:Enkephalins; D001127:Arginine Vasopressin; C015119:argipressin, des-GlyNH2(9)-; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie analogov vazopressina i énkefalina na khemoreaktivnye svoĭstva neĭronov sensomotornoĭ kory krys.