Glucose intolerance in cats given short-term therapies of prednisolone and megestrol acetate.
Six cats were each given prednisolone (2 mg/kg of body weight/day) and megestrol acetate (5 mg/cat/day) on separate occasions for 8 days. The drugs induced similar increases in fasting blood glucose concentrations and decreases in glucose excretion rates in the cats. Usually, each cat developed reduced tolerance of an IV glucose load; concomitant fasting hyperglycemia occurred in 3 cats after prednisolone therapy, and in 1 of these 3 cats after megestrol acetate.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002371:Cat Diseases / Q000097:blood / Q000139:chemically induced*; D002415:Cats; D005260:Female; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D008535:Megestrol / Q000009:adverse effects / Q000031:analogs & derivatives*; D019290:Megestrol Acetate; D011239:Prednisolone / Q000009:adverse effects*
D001786:Blood Glucose; D011239:Prednisolone; D008535:Megestrol; D019290:Megestrol Acetate