Nonsteroidal antiinflammatory agents. Part 16: Stereomeric 3-aryl-biphenylyl-hydroxy-propionic acids.
As part of a wider research project on structure-activity relationships of chiral arylalkanoic acids, stereomeric aryl- biphenylyl-hydroxypropionic acids 3a-d have been prepared and their antiinflammatory activity evaluated. Diastereomeric racemic erythro- and threo-acids have been synthesized by reaction of alpha-lithiated biphenylyl-acetic acid salts with the appropriate aldehyde. They were separated, and after attribution of their relative configuration by 1H-NMR analysis, resolved. The antiinflammatory activities of the enantiomeric potassium salts were determined by the carrageenan test.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000138:chemical synthesis*; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000138:chemical synthesis*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007274:Injections, Intraperitoneal; D008297:Male; D010666:Phenylpropionates / Q000008:administration & dosage / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism
D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; D010666:Phenylpropionates; D002351:Carrageenan