Sex-related hyperthermic response to chlorpromazine in the offspring of rats treated with imipramine.
The body temperature in male rats born to mothers treated with saline or imipramine (5 mg/kg, IMI-F1) from day 1 to day 21 of gestation showed a significant decline between 8 and 13 weeks of age. The magnitude of the decline was greater in the IMI-F1 rats than in saline-F1 rats. In contrast, the body temperature in the IMI-F1 female rats showed a significant rise between 8 and 13 weeks of age. Adult IMI-F1 male rats showed a significant hyperthermia for 1-2 h after an injection of chlorpromazine while the littermate female rats and the control male and female rats showed a marked hypothermia. The results suggest that prenatal exposure to imipramine induces sex-related alterations in the thermoregulatory centers.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D005260:Female; D006128:Growth / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013997:Time Factors
D007099:Imipramine; D002746:Chlorpromazine