Inhibition of phencyclidine percutaneous absorption by parenterally administered hypertonic saline.
Four hours after topical application of phencyclidine hydrochloride to hairless (hr-1/hr-1) mice, the mean hepatic concentration of phencyclidine (512.8 ng/g) was significantly lower for mice that had received intraperitoneal injections of sodium chloride, 1.75 mol/L (3500 mOsm/kg), than for control mice that had received equal volumes of water by the same route (2108.5 ng/g) (p less than 0.05). Hypertonic saline instilled intraperitoneally seemed to inhibit percutaneous absorption of phencyclidine hydrochloride. The effect may have been mediated by production of cutaneous dehydration.
D000818:Animals; D003864:Depression, Chemical; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010622:Phencyclidine / Q000378:metabolism*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012869:Skin Absorption / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology*
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D010622:Phencyclidine