[An analysis of tumor status of stage 3 carcinoma of the uterine cervix according to Cox's theory].
Four hundred and eighty three cases of primary stage 3 carcinoma of the uterine cervix which were treated at the National Institute of Radiological Sciences were analyzed with reference to the tumor status at the first examination, using Cox's proportional hazard model. Five prognostic factors, i.e. growth type of tumor, size of tumor at portio, size of uterus (including cervix and body), degree of tumor infiltration of parametrium and degree of tumor infiltration of vaginal wall, were considered. A coefficient of correlation, parameters of a hazard model, relative risk and survival functions were calculated with a program developed by us. The coefficient of correlation between the size of the uterus and the size of the tumor at the portio or the parametrial infiltration was about -0.5. Other combinations of prognostic factors indicated only a small correlation. When five prognostic factors were analyzed independently, the size of the uterus was found to have the greatest influence on the patient's prognosis and infiltration of the vaginal wall had the least. A combination of prognostic factors was selected according to the criterion of small correlation with each other. And then, the combination was evaluated for prognosis and to find the level of parameters under the asymtotic normal distribution. The best combination consisted of a growth type of tumor, a size of tumor at portio and tumor infiltration into the parametrium. Parameters of each prognostic factor which were calculated simultaneously from marginal likelihood were 0.236, 0.534 and 0.151, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
D000704:Analysis of Variance; D002277:Carcinoma / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology