[Action of the body fluorine of healthy persons and thyroidopathy patients on the function of hypophyseal-thyroid the system].
Altogether 123 persons were examined: 47 healthy persons, 43 patients with thyroid hyperfunction and 33 with thyroid hypofunction. It was established that prolonged consumption of drinking water with a raised fluorine content (122 +/- 5 mumol/l with the normal value of 52 +/- 5 mumol/l) by healthy persons caused tension of function of the pituitary-thyroid system that was expressed in TSH elevated production, a decrease in the T3 concentration and more intense absorption of radioactive iodine by the thyroid as compared to healthy persons who consumed drinking water with the normal fluorine concentration. The results led to a conclusion that excess of fluorine in drinking water was a risk factor of more rapid development of thyroid pathology. Indicators of the fluorine content in daily urine provide most of the information on changes of the fluorine amount in the body.
D000293:Adolescent; D000328:Adult; D004305:Dose-Response Relationship, Drug; D005457:Fluoridation; D005459:Fluorides / Q000502:physiology*; D005461:Fluorine / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects*; D013959:Thyroid Diseases / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*; D014881:Water Supply / Q000032:analysis
D005461:Fluorine; D005459:Fluorides
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