An unusual banded structure in Ewing's sarcoma.
In a largely haemorrhagic and necrotic specimen of Ewing's sarcoma we found banded structures (periodicity of banding about 250 nm) of a type hitherto not known to occur in any normal or pathological tissue. Morphological appearances suggested that these structures had evolved from the fibrin which was always closely associated with them. However, this idea was abandoned because the periodicity of banding of these structures is about ten times greater than the known periodicity of banding of fibrin. These structures have the same periodicity of banding as fibrous long-spacing collagen produced in vitro and about twice the periodicity of banding of fibrous long-spacing collagen found in vivo. However, they lack the fine striations or minor bands of the in vitro fibrous long-spacing collagen. We therefore conclude that the banded structures in this tumour represent a new form of fibrous long-spacing collagen which shares the features of in vitro and in vivo types of fibrous long-spacing collagen.
D001859:Bone Neoplasms / Q000648:ultrastructure*; D002648:Child; D003094:Collagen; D003599:Cytoskeleton / Q000648:ultrastructure; D005269:Femur; D005338:Fibrin Fibrinogen Degradation Products; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D012512:Sarcoma, Ewing / Q000648:ultrastructure*
D005338:Fibrin Fibrinogen Degradation Products; C011468:fibrinmonomer; D003094:Collagen