[The role of the body's defense against tumors by regional lymph nodes].
The role of bodily defense against tumor by regional lymph nodes was discussed in this study, especially focused on anti-tumor effect. Anti-tumor immune response was observed in regional lymph nodes in the tumor-bearing mouse. Advance of tumor or distance between lymph nodes and tumor effected the strength of the immune responses. In clinical study, anti-tumor immune response was observed similarly on draining lymph nodes of gastric cancer or colo-rectal cancer by measuring the PHA lymphocyte blastogenesis formation, the natural killer activity and the T-cell subpopulation. The response of regional lymph nodes was suppressed in early stage cases, while that of remote nodes was preserved comparatively. As is stated above, anti-tumor immune response was confirmed in draining lymph nodes. This suggested that at least for early gastric cancer without lymph node metastasis, surgical treatment with limited lymph node dissection should be considered in order to preserve bodily defense mechanism of regional lymph nodes.
D000818:Animals; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D013274:Stomach Neoplasms / Q000276:immunology*