Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon.
Human adenovirus-12-transformed cells express greatly reduced levels of the major histocompatibility complex class I antigens and are highly tumorigenic in syngeneic hosts. The finding that expression of a transfected class I gene is sufficient to abrogate their tumorigenicity underscores the importance of defining the conditions that will lead to derepression of endogenous class I genes in these cells. Brief treatment of Ad12-transformed cells with interferon results in the rapid but transient expression of class I antigens, and these interferon-treated cells have significantly reduced tumorigenicity in immunocompetent hosts. We have further demonstrated that subcutaneous administration of interferon, subsequent to the introduction of a tumorigenic dose of Ad12-transformed cells, results in complete protection against this tumor. The ability of interferon to "induce" class I gene expression may be an important modality in the treatment of a variety of spontaneous tumors that exhibit greatly reduced levels of class I antigens on their cell surface.
D000260:Adenoviruses, Human / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006183:H-2 Antigens / Q000235:genetics*; D007370:Interferon Type I / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014162:Transfection
D006183:H-2 Antigens; D007370:Interferon Type I