title: Rabbit thymus gangliosides: species- and organ-specific distribution, age-dependence and their cell biological significance.
abstract: Gangliosides of thymuses from rabbit, mouse, rat, calf, and man were analyzed. The ganglioside compositions of the thymuses showed species specificities, and the compositions of the species other than the rabbit were found to be markedly different from that of the rabbit, which contained characteristically substantial amounts of IV3NeuGc-nLc4Cer and VI3NeuGc-nLc6Cer (Iwamori, M. & Nagai, Y. (1981) Biochim. Biophys. Acta 665, 214-220). The inter-species differences in the thymus ganglioside compositions were not remarkable in the 8 mouse and 2 rabbit strains examined. Rabbit thymocytes, but not those of mouse and rat, were lysed with human Hanganutziu-Deicher serum in the presence of guinea pig complement, reflecting the high content of gangliosides containing N-glycolylneuraminic acid in rabbit thymus. As to age-dependent changes of gangliosides in rabbit thymus and spleen, the concentrations gradually decreased with age, while the molar ratio of total gangliosides to total phospholipids was constant in the spleen throughout life and in the thymus at 3, 4, and 6 weeks of age. It was noted that old (180 weeks of age) rabbit thymus, which is occupied largely by fat tissue, still contained a significant amount of neolactoseries gangliosides.
mesh_terms: D000367:Age Factors; D000818:Animals; D000906:Antibodies / Q000276:immunology; D002417:Cattle; D003165:Complement System Proteins / Q000276:immunology; D005732:Gangliosides / Q000032:analysis* / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000032:analysis; D013045:Species Specificity; D013154:Spleen / Q000032:analysis; D013950:Thymus Gland / Q000032:analysis*
chemical_list: D000906:Antibodies; D005732:Gangliosides; D012794:Sialic Acids; D003165:Complement System Proteins