Effect of phenytoin on [3H]norepinephrine release from synaptosomes.
Phenytoin reduces depolarization-linked [3H]norepinephrine release from rat brain synaptosomes. When choline chloride was substituted for NaCl the phenytoin effect was attenuated but still significant. This is consistent with the theory that phenytoin reduces both Na and Ca influx during depolarization.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002021:Buffers; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D010672:Phenytoin / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism*
D002021:Buffers; D010672:Phenytoin; D011189:Potassium Chloride; D012964:Sodium; D009638:Norepinephrine