title: Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii.
abstract: Investigation of the MeOH extracts of Sargentia greggii (Rutaceae) led to the isolation of two known flavones, zapotin and 5,6,2'-trimethoxyflavone, and a new flavone, 5,6,2',3',4',6'-hexamethoxyflavone (1), whose structure was established by spectral data and confirmed by total synthesis. In addition, two known coumarins, 3-(alpha,alpha-dimethylallyl) herniarin and seselin, and a new coumarin, O-geranylosthenol (3), have been isolated from this plant. The structure of 3 was deduced from spectral data. Although the crude extracts displayed KB activity, none of the crystalline compounds were significantly active.
mesh_terms: D000470:Alkaloids / Q000032:analysis*; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D003374:Coumarins / Q000032:analysis*; D005419:Flavonoids / Q000032:analysis*; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D005419:Flavonoids; D010936:Plant Extracts