Chemical probes and possible targets for the induction of aneuploidy.
There is an increasing interest in developing assay systems that are effective in detecting aneuploidy-producing agents. Because the current methodology for detecting aneuploidy is extremely varied, presently no comparisons of the validity and sensitivity of various assays can be made. This is due to a lack of sufficient data on the testing of the same compounds in multiple systems. Thus, there is an imminent need to select a few model compounds to be tested in all the available assays. This chapter discusses the rationale for the selection of model compounds. Approximately 30 compounds were identified as candidate compounds for various reasons. It is not our intention to discourage studies of compounds not discussed in this chapter. It is merely our effort to facilitate the final selection of a few model compounds to be used for comparative studies in diverse assays or for collaborative studies to determine interlaboratory variation of selected assays.
D000782:Aneuploidy; D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure; D003434:Crossing Over, Genetic; D004330:Drosophila / Q000187:drug effects / Q000235:genetics; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005658:Fungi / Q000187:drug effects; D008540:Meiosis; D008957:Models, Genetic; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D010944:Plants / Q000187:drug effects / Q000235:genetics; D013723:Teratogens
D009153:Mutagens; D013723:Teratogens