[New derivatives of clofibrate and probucol. Preliminary study of their hypolipemic activity].
The preparation is reported of compounds with a free or esterified hydroxyisobutyric acid grouping characteristic of clofibrate, on various supporting molecules related to clofibrate itself or to probucol. Some compounds showed clear hypolipemic activity and for one compound (MG 6893) the effect was not accompanied by hepatomegalia.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002994:Clofibrate / Q000031:analogs & derivatives*; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010636:Phenols / Q000494:pharmacology*; D011092:Polyethylene Glycols; D011341:Probucol / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000960:Hypolipidemic Agents; D010636:Phenols; D011092:Polyethylene Glycols; D002994:Clofibrate; D011341:Probucol
Nuovi derivati del clofibrato e del probucol. Studio preliminare dell'attività ipolipemizzante.