2H and 31P NMR study of the interaction of general anesthetics with phosphatidylcholine membranes.
The effect of the general anesthetics alpha-chloralose and chloral hydrate as well as the nonanesthetic beta-chloralose on the order of phosphatidylcholine and phosphatidylcholine-cholesterol liposomes has been examined by 2H nuclear magnetic resonance. Chloral hydrate interacts with the hydrophilic head-group region, causing a change in the torsion angle of the C alpha-C beta bond. The membrane interior is also disordered by the presence of this agent. alpha-Chloralose, on the other hand, disorders only the central position of the membrane. beta-Chloralose produces little significant change in bilayer order.
D002697:Chloral Hydrate; D002698:Chloralose; D007700:Kinetics; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008954:Models, Biological; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship
D008081:Liposomes; D010713:Phosphatidylcholines; D002698:Chloralose; D002697:Chloral Hydrate