Synergistic effect of herpes simplex virus and cytosine arabinoside on human chromosomes.
The combined treatment of cultures of human embryonic lung cells with herpes simplex virus type 2 and cytosine arabinoside produced a significantly increased number of cells containing multiple chromatid and chromosome breaks. The incidence of such cells was found to be approximately two and one half times greater than the additive effects of virus and cytosine arabinoside induced separately and is therefore synergistic.
D001345:Autoradiography; D002460:Cell Line; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D046508:Culture Techniques; D003561:Cytarabine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005826:Genetics, Medical; D006801:Humans; D007668:Kidney; D008168:Lung; D009705:Nucleosides / Q000378:metabolism; D012118:Resorcinols; D018139:Simplexvirus / Q000472:pathogenicity*; D013194:Staining and Labeling; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D009705:Nucleosides; D012118:Resorcinols; D003561:Cytarabine; D014316:Tritium; D004247:DNA; D013936:Thymidine