[Effects of administration of moderate doses of etretinate (RO 10-9359) on rats deficient in vitamin A].
Etretinate (RO 10-9359) is a synthetic retinoid used instead of Vitamin A--toxic in large dose--during treatment of some skin diseases. In this work biological properties of Etretinate were studied by administration of this drug (2 mg/kg/day) in rats in a vitamin A-deficient state. Body growth, some seric parameters and some tissue enzymatic activities were studied. Results of this restitution experiment show that Etretinate corrects all parameters affected by vitamin A-deficiency testicular growth excepted. So Etretinate exhibits properties similar to that of retinoic acid.
D000818:Animals; D001835:Body Weight; D004032:Diet; D005050:Etretinate / Q000008:administration & dosage / Q000627:therapeutic use*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008297:Male; D010734:Phosphogluconate Dehydrogenase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013963:Thyroid Hormones / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014802:Vitamin A Deficiency / Q000188:drug therapy* / Q000378:metabolism
D013963:Thyroid Hormones; D014801:Vitamin A; D005050:Etretinate; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Effets de l'administration de doses moderées d'étrétinate (RO 10-9359) á des rats carences en vitamine A.