Increased accumulation of lipoprotein and cholesterol in re-endothelialized rat carotid artery after laser damage.
The permeability characteristics of acute endothelial lesions and completely regenerated endothelium were investigated. The endothelium of rat carotid arteries was selectively damaged by laser irradiation. When [125I]LDL was injected 24 h later, the average [125I]LDL uptake in the damaged arteries was about 13 times the uptake by the non-irradiated, contralateral control arteries. Fourteen weeks after the irradiation, the vessel walls with regenerated endothelium had taken up twice as much [125I]LDL as the controls. Sixteen weeks after the irradiation, orally administered [3H]cholesterol was accumulated 5 times more by the irradiated than by the control vessel wall. These findings show that the adherent platelets contribute importantly to the LDL cholesterol accumulation by the vessel wall with acute endothelial lesion and that the regenerated endothelium promotes the accumulation of LDL cholesterol.
D000818:Animals; D001693:Biological Transport, Active; D002339:Carotid Arteries / Q000378:metabolism* / Q000502:physiology / Q000528:radiation effects; D002784:Cholesterol / Q000378:metabolism*; D004727:Endothelium / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects; D007834:Lasers; D008074:Lipoproteins / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D010539:Permeability; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002784:Cholesterol