Synthesis and some biological properties of new derivatives of 1-S-phenylthioglycolonitrile.
A series of new S-phenylthioglycolic acid derivatives was synthetized via common transformations of alkylated S-phenyl-thioglycolonitrile. The compounds were submitted to pharmacological screening. N,N-Diethylaminoethyl ester of 1-S-phenylcyclopentane carboxylic acid was submitted to detailed studies and showed high local anesthetic properties.
D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents; D001646:Bile / Q000378:metabolism; D001763:Blepharoptosis; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010830:Physostigmine / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology; D013329:Structure-Activity Relationship; D013864:Thioglycolates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000779:Anesthetics, Local; D000893:Anti-Inflammatory Agents; D007202:Indicators and Reagents; D013864:Thioglycolates; D012110:Reserpine; D010830:Physostigmine