[Impairment of lipid metabolism in the liver and its correction after exposure to ethanol and antitubercular agents].
Impairments in the lipid spectrum of rat liver tissue, developed as a result of long-term simultaneous effect of ethanol and antituberculosis drugs isoniazid ann rifampycin, were effectively corrected by means of phospholipid preparations as well as by legalone (sylimarine). Pyridoxine, tocopherol and ATP did not normalize the lipid metabolism under these conditions.
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000818:Animals; D000995:Antitubercular Agents / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010743:Phospholipids / Q000378:metabolism; D011736:Pyridoxine / Q000627:therapeutic use; D051381:Rats; D012838:Silymarin / Q000627:therapeutic use; D014810:Vitamin E / Q000627:therapeutic use
D000995:Antitubercular Agents; D008077:Lipoproteins, LDL; D010713:Phosphatidylcholines; D010743:Phospholipids; D012838:Silymarin; C011246:essential 303 forte; D014810:Vitamin E; D000431:Ethanol; D000255:Adenosine Triphosphate; D011736:Pyridoxine
Narusheniia lipidnogo obmena i ikh korrektsiia pri vozdeĭstvii na pechen' étanola i protivotuberkuleznykh sredstv.