title: Corneal argyrosis: histologic, ultrastructural and microanalytic study.
abstract: The clinical, histopathological, ultrastructural and microanalytic features of a case of iatrogenic ocular argyrosis are reported. The case, in a 63-year-old woman with long-standing herpetic keratitis, was unusual in that it occurred after apparently only one treatment with eyedrops consisting of a 1% solution of "mild silver protein" (Argyrol). Another unusual feature was that the silver deposited in the cornea was mainly conjugated to sulfur; selenium, which commonly demonstrates a high affinity for silver in tissues, was detectable in only trace amounts.
mesh_terms: D001129:Argyria / Q000209:etiology* / Q000473:pathology; D003315:Cornea / Q000032:analysis / Q000648:ultrastructure; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy; D008875:Middle Aged; D009883:Ophthalmic Solutions; D012652:Self Mutilation; D012836:Silver Proteins / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D009883:Ophthalmic Solutions; D012836:Silver Proteins