Inhibitors of collagenolytic enzymes in the serum of patients with chronic liver disorders.
Inhibitory effect of serum on collagenolysis was studied in rat hepatic slices. Sera of patients with cirrhosis contained low concentrations of inhibitors. Higher concentrations were found in sera from patients with chronic active hepatitis and chronic persistent hepatitis, than in healthy individuals. It is suggested that changes of the serum inhibitory activity are responsible for the control of collagen degradation in the injured liver.
D000328:Adult; D000818:Animals; D002908:Chronic Disease; D003094:Collagen / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000097:blood*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D008107:Liver Diseases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011919:Rats, Inbred Strains
D004791:Enzyme Inhibitors; D003094:Collagen; D006909:Hydroxyproline