[Method for the quantitative analysis of competitive antagonism in isolated organs].
It has been shown in experiments on smooth muscle strips of the rat stomach that quantitative criteria of competitive antagonism, based on the acting mass law are not adhered to in studying acetylcholine and atropine interaction in a large range of concentrations (10(-8)-10(-3) M): the effect of low concentrations of the agonist is inhibited to a larger degree than that of high ones.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004553:Electric Conductivity; D066298:In Vitro Techniques; D008722:Methods; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D012996:Solutions
D012996:Solutions; D001285:Atropine; D000109:Acetylcholine
K metodike kolichestvennogo analiza konkurentnogo antagonizma na izolirovannykh organakh.