Influence of several bacterial and viral vaccines on hepatic drug metabolism in mice.
Pentobarbital-induced sleeping time was found to be significantly prolonged in mice within at least 4 days following either whooping cough, tetanus, rubella or poliomyelitis vaccination. By contrast, barbital-induced sleeping time remained unaffected, These findings provide further evidence of a correlation between inhibition of liver drug metabolizing enzymes and stimulation of the immune response.
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000378:metabolism* / Q000494:pharmacology; D010567:Pertussis Vaccine / Q000494:pharmacology*; D011054:Poliovirus Vaccine, Inactivated / Q000494:pharmacology*; D012411:Rubella Vaccine / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013745:Tetanus Toxoid / Q000494:pharmacology*
D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D012411:Rubella Vaccine; D013745:Tetanus Toxoid; D001462:Barbital; D010424:Pentobarbital