Morphometric changes in alcoholic mice of neurons of areas 6 and 17 and ependyma of the subcommissural organ.
We have performed a karyometric study of the postnatal development of the subcommissural organ (SOC), the subjacent thalamic ependyma, and the pyramidal neurons of layer V of the motor and visual cortical areas, in alcoholic male albino mice, aged 25-100 days. Ethyl alcohol was added to the drinking water at a concentration of 20%, from birth until the day of sacrifice. Our results show that alcoholism affects the SOC ependyma and the motor cortex, and, apparently, does not affect the ventricular thalamic ependyma and the visual cortex. We suggest a neuroendocrine mechanism to explain the SOC answer, and a functional deprivation to explain the changes in the motor cortex.
D000375:Aging; D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004805:Ependyma / Q000187:drug effects; D007620:Karyometry; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009044:Motor Cortex / Q000187:drug effects; D009474:Neurons / Q000473:pathology; D009490:Neurosecretory Systems / Q000187:drug effects*; D013351:Subcommissural Organ / Q000187:drug effects* / Q000473:pathology; D013787:Thalamic Nuclei / Q000187:drug effects / Q000473:pathology; D014793:Visual Cortex / Q000187:drug effects