Effects of bremazocine on locomotor activity in DBA/2 and C57BL/6 mice.
The effects of the benzomorphan analogue bremazocine on locomotor activity were studied in DBA/2 (DBA) and C57BL/6 (C57) mice. Three sets of experiments were carried out. In a first set, bremazocine depressed activity in both strains, but DBA mice were more sensitive to the effects of the drug. In a second set of experiments the effects of bremazocine were antagonized by a per se ineffective dose (0.5 mg/kg) of the selective kappa-opioid receptor antagonist MR 1452, showing that they were mediated through an interaction with this sub-population of opioid receptors. In a third set of experiments the effects of bremazocine were enhanced by the administration of a per se ineffective dose (0.025 mg/kg) of haloperidol, showing the involvement of dopaminergic mechanisms.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001575:Benzomorphans / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009019:Morphinans / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009292:Narcotic Antagonists / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects; D013045:Species Specificity
D000700:Analgesics; D001575:Benzomorphans; D009019:Morphinans; D009292:Narcotic Antagonists; D011954:Receptors, Dopamine; C029552:Mr 1452; C027248:bremazocine; D006220:Haloperidol