title: [Asarone and its biological properties].
abstract: In acute and chronic experiments on mice, rats, cats and rabbits in a wide range of tests, a study was conducted of the biological properties of alpha-asarone (1-propenyl-2,4,5- methoxybenzol)--etherophenol, isolated by the authors from the roots of Asarum europaeum. It was determined that the LD50 of asarone for mice in enteral administration was 417.6 mg/kg, in intra-abdominal--310 mg/kg. The preparation has quite diverse biological activity--tranquilizing, sedative, antiulcer, spasmolytic and antisclerosing. In its pharmacological properties the studied asarone is identical with asarone obtained from Acorus calamus and Guatteria.
mesh_terms: D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001161:Arteriosclerosis / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D007674:Kidney Diseases / Q000139:chemically induced / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D009129:Muscle Tonus / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; C012195:asarone
vernacular_title: Azaron i ego biologicheskie svoĭstva.