Estimating the parameters in the two-component model for cell survival from experimental quantal response data.
A statistical technique is given which can be used to estimate the parameters of the two-component model for cell survival from quantal response multifraction data. The method is a nonlinear logistic regression and relies on a mild assumption relating the probability of death to cell survival level. The method is demonstrated on mouse colon data, where more efficient estimates of the parameters are known, and the agreement is good. Also for some mouse lung LD50 data we obtain estimates of the parameters, and the fit to the data is shown to be better than that of linear-quadratic model.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D003106:Colon / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D008433:Mathematics; D051379:Mice; D008954:Models, Biological