[Effect of hyperthermia on the radioprotective action of cysteamine and isoproterenol].
Heating of mouse bone marrow cells up to 42 degrees C was shown to increase their radiosensitivity (DMF = 0.80 +/- 0.12). At this temperature, the radioprotective efficiency of cysteamine was lost completely (DMF = 0.78 +/- 0.09), and radioprotective activity of d,l-isoproterenol significantly decreased (DMF declined from 2.41 +/- 0.23 to 1.67 +/- 0.16). It is assumed that the radioprotective effect of cysteamine on mammalian cells is associated with the processes of the postirradiation DNA repair for just these processes are inhibited by heating. The mechanism of action of a beta-agonist of isoproterenol is perhaps only partially associated with DNA repair.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003543:Cysteamine / Q000494:pharmacology*; D006358:Hot Temperature; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; D003543:Cysteamine; D007545:Isoproterenol
Vliianie gipertermii na radiozashchitnoe deĭstvie tsisteamina i izoproterenola.