[Changes in the lesser circulation as affected by armin].
Experiments on narcotized cats have shown that intravenous administration of armine in DL50 (0.2 mg/kg) decreases the pulmonary blood flow by 52%. The reduction of the pulmonary blood flow is accompanied by a drop of pressure in the femoral artery, development of bronchoconstriction, bradycardia and arterial hypoxemia. The pressure in the lung artery remains rather high. At the beginning of intoxication the decrease of the pulmonary blood flow correlates with bronchoconstriction in a greater degree than with other indicators and as the pathological process deepens, the reduction of the pulmonary blood flow gets closely connected with bradycardia.
D000818:Animals; D001138:Armin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011652:Pulmonary Circulation / Q000187:drug effects*; D013997:Time Factors
D009943:Organophosphorus Compounds; D001138:Armin; D010100:Oxygen
Izmenenie krovoobrashcheniia v malom kruge pod vliianiem armina.