title: Intraocular injection of lidocaine.
abstract: Lidocaine was inadvertently injected intraocularly in three patients. In the one patient who had not received prior mydriatics, the drug caused immediate dilation and paralysis of the pupil and diminished visual acuity to counting fingers. Retinal function began to improve after four hours and both retinal and pupillary function recovered completely by 16 hours. A second patient also recovered completely. The third patient developed a permanent field defect. The effects of intraocular lidocaine were then studied in an animal model. Lidocaine temporarily paralyzed the pupil in mydriasis and temporarily extinguished the b-wave of the electroretinogram. Light and electron microscopy study of the retina revealed no damage beyond that at the perforation site.
mesh_terms: D000818:Animals; D002415:Cats; D004596:Electroretinography; D005123:Eye / Q000187:drug effects*; D006801:Humans; D007049:Iatrogenic Disease; D007267:Injections / Q000009:adverse effects; D007429:Intraocular Pressure / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology*; D008854:Microscopy, Electron; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D012167:Retinal Perforations / Q000209:etiology; D012607:Scotoma / Q000209:etiology; D013997:Time Factors
chemical_list: D008012:Lidocaine