title: [Pipemidinic acid as a urinary antiseptic--microbiological and clinical study].
abstract: The authors present the results from the microbiological and clinical studies about the potentialities of pipemidinic acid in the treatment of uroinfections. Pipemidinic acid was established with the study on 375 bacterial strains, isolated from the urine of urological patients to have a very good in vitro effect as regards E. coli, Citrobacter, Proteus retgeri, Proteus mirabilis, Klebsiella and Enterobacter, and in case of those microorganisms, it gives way only to some aminoglucoside antibiotics. The admit that with those causative agents of uroinfections, the pipemidinic acid could be the agent of choice. The percentage of susceptible strains is low in case of Seratia, Proteus vulgaris, Pseudomonas and Acunetobacter. Sanation of the uroinfection was attained in 56.2 per cent of the patients from the 32 patients treated with persistent, most often nosocomial uroinfection, by the pipemidinic acid (in the form of the preparation palin), and a reduction of the bacterial number to insignificant values--in 12,6%. Obvious clinical improvement was established in almost all patients treated, manifested with fading or considerable reduction of the subjective and physical symptoms of the uroinfection, in parallel with a normalization or improvement of the paraclinical laboratory indices as well. In conclusion, it was emphasized that the introduction of that uroantiseptic in the practice will broaden the possibilities of effective treatment of uroinfections.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D009539:Nicotinic Acids / Q000627:therapeutic use*; D010876:Pipemidic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology; D014556:Urine / Q000382:microbiology*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D009539:Nicotinic Acids; D010876:Pipemidic Acid
vernacular_title: Pipemidinovata kiselina kato uroantiseptik--mikrobiologichni i klinichni prouchvaniia.