Radioprotection of the kidney with degradable microspheres. A pilot study in the dog with repeated irradiation.
The left kidney of 9 dogs was irradiated daily for three days with 300 kVp X-rays. Radioprotection was attempted in 5 of the kidneys by administration of degradable microspheres in the renal artery, immediately before irradiation. Protected kidneys received 3 X 8 or 3 X 12 Gy in midplane dose, unprotected kidneys 3 X 5.2 or 3 X 8 Gy. A protective effect due to induced hypoxia could be demonstrated in creatinine clearance, which was significantly higher in protected than in unprotected kidneys at 7 - 13 weeks after irradiation.
D000818:Animals; D004285:Dogs; D007668:Kidney / Q000502:physiology / Q000528:radiation effects*; D008863:Microspheres; D009929:Organ Size / Q000528:radiation effects; D010865:Pilot Projects; D011829:Radiation Dosage; D011835:Radiation Protection; D013213:Starch / Q000008:administration & dosage
D013213:Starch