title: [Successive changes in the blood composition of experimental normal beagle dogs associated with age].
abstract: Eight hematologic parameter values, 16 serum biochemical constituents, serum protein fractions and albumin-globulin ratios were determined in blood samples obtained from 879 normal, healthy Beagle dogs of both sexes which had been reproduced and bred in our laboratories. The blood samples were collected from the Beagles that ranged in monthly ages from 1 to 12 and in monthly ages from 13 to 121, which were classified as the adult class. As a result, red blood cell counts, hemoglobin concentrations and packed cell volumes increased with growth. Red blood cell parameters of normal Beagles in our laboratories were rather higher than those in literatures presented by many other researchers. MCV decreased and MCHC increased gradually with age. Total serum protein concentrations increased with growth. alpha 1-1 and alpha 1-2 Globulin fractions descended, but beta 2 and gamma globulin fractions ascended in serum proteins. Alkaline phosphatase activities, inorganic phosphorus concentrations and glucose concentrations decreased conspicuously with growth. Leucine aminopeptidase activities and calcium concentrations decreased slightly. Serum cholinesterase and LDH activities showed a tendency to diminish similarly. Blood urea nitrogen and creatinine concentrations multiplied gradually. Hematologic parameters became almost steady in our 7-month-old dogs or older ones and serum biochemical constituents had a tendency to be stable in our 7- to 9-month-old dogs or older ones in the blood. White blood cell counts, alkaline phosphatase activities, inorganic phosphorus concentrations, glucose concentrations, leucine aminopeptidase activities and calcium concentrations were lowest in the adult class.
mesh_terms: D000375:Aging; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000097:blood; D004285:Dogs / Q000097:blood*; D005260:Female; D006403:Hematologic Tests; D008297:Male; D010758:Phosphorus / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis
chemical_list: D001786:Blood Glucose; D012709:Serum Albumin; D012712:Serum Globulins; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium