Inhibitory effect of glucocorticoid hormones on the growth of Inoue-Melnick virus.
Glucocorticoid hormones inhibited the early stage of propagation of Inoue-Melnick virus in a dose-dependent manner in human diploid cell cultures. Prednisolone and hydrocortisone achieved complete inhibition of replication of the three Inoue-Melnick virus serotypes at concentrations of 0.2 X 10(-4) and 10(-5) M, respectively; strong inhibition was found even at 10(-5) and 10(-6) M, respectively. The steroid hormones did not show a direct effect on the virus.
D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D009103:Multiple Sclerosis / Q000382:microbiology; D009187:Myelitis / Q000382:microbiology; D009902:Optic Neuritis / Q000382:microbiology; D011239:Prednisolone / Q000494:pharmacology*; D013577:Syndrome; D014780:Viruses / Q000187:drug effects* / Q000254:growth & development
D011239:Prednisolone; D006854:Hydrocortisone