title: Acute toxicity of monochlorophenols, dichlorophenols and pentachlorophenol in the mouse.
abstract: Acute oral LD50 values were determined for 2-, 3-, and 4-chlorophenol, 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5 dichlorophenol and pentachlorophenol in male and female mice. LD50 values (mg/kg) ranged from 117 (females) and 177 (males) for pentachlorophenol to 2389 (females) and 2643 (males) for 3,5-dichlorophenol. It was found that 2-chlorophenol and 3-chlorophenol were considerably more toxic than the dichlorophenol series. Values for males and females were generally similar, the major differences being with pentachlorophenol and 2,5-dichlorophenol, where in both cases the female LD50 was lower.
mesh_terms: D000818:Animals; D002733:Chlorophenols / Q000633:toxicity*; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010416:Pentachlorophenol / Q000633:toxicity*; D051381:Rats; D012737:Sex Factors; D013329:Structure-Activity Relationship
chemical_list: D002733:Chlorophenols; D010416:Pentachlorophenol