title: [Comparative study of the safety and reactogenicity of different doses of brucellosis chemical vaccine in human revaccination].
abstract: The period of 11-12 months has been found to be the optimal interval, among other experimentally tested periods of time, between primary immunization and booster immunization with chemical brucellosis vaccine. The safety and low reactogenicity of different doses (1 mg, 0.75 mg and 0.5 mg) of the vaccine have been established. The occurrence and intensity of local and systemic reactions to this vaccine depend neither on the dose of the preparation, nor on previous immunization.
mesh_terms: D000942:Antigens, Bacterial; D002004:Brucella Vaccine / Q000009:adverse effects* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005334:Fever / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000009:adverse effects*; D012882:Skin Tests; D013997:Time Factors
chemical_list: D000942:Antigens, Bacterial; D002004:Brucella Vaccine; C005641:brucellin
vernacular_title: Sravnitel'noe izuchenie bezvrednosti i reaktogennosti razlichnykh dozirovok brutselleznoĭ khimicheskoĭ vaktsiny pri revaktsinatsii liudeĭ.