Inhibition of feline spinal cord dorsal horn neurons following electrical stimulation of nucleus paragigantocellularis lateralis. A comparison with nucleus raphe magnus.
The effect of electrical stimulation applied to the nucleus paragigantocellularis lateralis (PGL) was assessed on the somatosensory responses of functionally identified spinal cord dorsal horn neurons in the cat. Neurons were classified as low threshold mechanoreceptive, wide dynamic range or nociceptive specific. The responses of over 95% of all neurons tested were inhibited by a conditioning stimulus to the PGL. For each cell the threshold current intensity necessary to produce inhibition from the PGL (inhibitory threshold) was determined. Analysis of the incidence of inhibition and the inhibitory thresholds showed that the PGL-induced inhibition was not selective for a particular class of neuron. Due to the many similarities between the PGL and the nucleus raphe magnus (NRM), a comparison was made between each region's potency in inhibiting the responses of spinal cord neurons. Based on an analysis of inhibitory thresholds, the PGL was found to be significantly more potent than the NRM. These results indicate the PGL to be an important site from which descending modulation of spinal cord somesthetic information emanates.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D004594:Electrophysiology; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology*; D009433:Neural Inhibition; D009474:Neurons / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology; D011903:Raphe Nuclei / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*