Contrast enhancement of the liver and blood. Nonionic versus ionic contrast media in the pig.
The contrast enhancement of low-osmolality (iohexol) and high-osmolality (diatrizoate) contrast media was compared in 18 pigs following intravenous bolus administration. Liver and blood attenuation and blood sample iodine concentration were measured during the first 3 minutes after injection. Iohexol produced a significantly higher contrast enhancement in the blood during the period from 0.5 to 3 minutes after injection. Diatrizoate produced a significantly higher contrast enhancement in the liver during the period from 9 to 30 minutes after injection. The greater contrast enhancement of iohexol during the acute phase should be advantageous in dynamic CT.
D000818:Animals; D001011:Aorta; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine; D007455:Iodine / Q000097:blood*; D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D007472:Iohexol; D008099:Liver / Q000000981:diagnostic imaging*; D009994:Osmolar Concentration; D013552:Swine; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids
D007457:Iodine Radioisotopes; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol; D007455:Iodine