title: Nippostrongylus brasiliensis: changes in plasma levels of gastrointestinal hormones in the infected rat.
abstract: Plasma concentrations of gastrointestinal hormones were measured by radioimmunoassay in fasted rats 9 days after infection with a range of doses of Nippostrongylus brasiliensis. Values for infected rats fed ad libitum were compared with those of weight matched, pair fed, uninfected rats to control for the possible effects of dose-dependent reductions in food intake associated with infection. The plasma concentrations of some of the gastrointestinal hormones in infected rats were very different from those of their pair fed partners. The magnitude and direction of the changes varied according to the hormone being examined. Plasma concentrations of gastrin and pancreatic polypeptide were similar in pair fed and infected rats at all doses used. For the other hormones assayed, infection was associated with dose-related changes. The plasma concentrations of cholecystokinin and insulin were slightly but significantly reduced in infected rats. In contrast, secretin, enteroglucagon, and pancreatic glucagon concentrations were markedly increased. At the highest dose given (52 larvae/g body wt), the plasma levels of secretin and enteroglucagon in infected rats were elevated 9 X and 15 X, respectively. A comparison of the changes seen in N. brasiliensis-infected rats with those reported for other helminth infections revealed striking differences. The possible etiology of alterations in plasma gastrointestinal hormone concentrations and their contribution to the pathological changes seen in animals infected with helminths are discussed.
mesh_terms: D000818:Animals; D001835:Body Weight; D002766:Cholecystokinin / Q000097:blood; D002149:Energy Intake; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D005934:Glucagon / Q000097:blood; D004763:Glucagon-Like Peptides / Q000097:blood; D008297:Male; D009349:Nematode Infections / Q000097:blood*; D009559:Nippostrongylus; D010191:Pancreatic Polypeptide / Q000097:blood; D051381:Rats; D012633:Secretin / Q000097:blood
chemical_list: D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D010191:Pancreatic Polypeptide; D004763:Glucagon-Like Peptides; D005934:Glucagon; D002766:Cholecystokinin