Factors modifying contrast media induced fibrillation.
Factors effecting contrast media induced ventricular fibrillation were studied in anesthetized dogs using contact time as the measured parameter. Injections of meglumine/sodium diatrizoate (370 mg I/ml) were made into the right coronary artery at 0.4 ml/s until fibrillation occurred. A contrast medium containing calcium chelators was found to produce fibrillation in a significantly shorter contact time than a similar medium without calcium chelators. Pre-treatment by the cardiac glycoside, ouabain, increased the contact time for fibrillation as did the production of a sub-acute infarction in the left coronary artery and a previous fibrillation and resuscitation. The data suggest that calcium binding additives increase the risk of fibrillation while pre-treatment with cardiac glycosides, the presence of stable infarcts in the non-injected areas, or a previous fibrillation and resuscitation do not increase risk.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002614:Chelating Agents / Q000627:therapeutic use; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003973:Diatrizoate / Q000009:adverse effects; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004285:Dogs; D004338:Drug Combinations / Q000009:adverse effects; D009203:Myocardial Infarction / Q000139:chemically induced; D010042:Ouabain / Q000627:therapeutic use; D012306:Risk; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D002614:Chelating Agents; D003287:Contrast Media; D004338:Drug Combinations; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D010042:Ouabain; C027278:urovision; D002118:Calcium