title: Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15.
abstract: A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-1, and that the map distances are 25.9 +/- 4.9 between C-6 and Gpt-1, and 36.4 +/- 5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-6b for the allele encoding C6B.
mesh_terms: D000410:Alanine Transaminase / Q000235:genetics; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003183:Complement C6 / Q000235:genetics*; D004586:Electrophoresis; D008040:Genetic Linkage; D005993:Glycerolphosphate Dehydrogenase / Q000235:genetics; D051379:Mice / Q000235:genetics*
chemical_list: D003183:Complement C6; D005993:Glycerolphosphate Dehydrogenase; D000410:Alanine Transaminase