[The role of pyridine nucleotide cofactors in the reaction of microsomal N-demethylation under normal conditions and in tumor pathology].
Functions of pyridine nucleotide cofactors NADPH and NADH in N-demethylation of amidopyrine were studied under conditions of normal and malignant states. Contribution of NADH-specific transfer of electrons to microsomal N-demethylation was gradually augmented in the sequence: microsomes from liver tissue of rats with Zajdela hepatoma--microsomes of ascites hepatocytes. In this sequence both synergic effect of these cofactors and the rate of N-demethylcation, if NADH was used as a cofactor, were increased.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D004579:Electron Transport; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D051381:Rats
D003573:Cytochrome b Group; D009243:NAD; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase
Uchastie piridinnukleotidnykh kofaktorov v reaktsii mikrosomal'nogo N-demetilirovaniia v norme i pri opukholevoĭ patologii.