title: [Effect of leontoside and polysponin on thyroid function, lipids and the anticoagulation system of blood in rabbits with alimentary hypercholesterolemia].
abstract: The feeding of rabbits with initial normo- and hypofunction of the thyroid with cholesterol inhibits its function, particularly at late times of experiment, which is accompanied by an increase in the blood lipid level, and inhibition of the blood anticoagulation system. Administration of leontoside (2.5 mg/kg) in conjunction with cholesterol stimulates thyroid function, activates the blood anticoagulation system and lowers the lipid content in the blood serum. Administration of polysponine produces an analogues but less pronounced action.
mesh_terms: D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006027:Glycosides / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D007037:Hypothyroidism / Q000188:drug therapy; D008055:Lipids / Q000097:blood*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011817:Rabbits; D012503:Saponins / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000187:drug effects*; D014315:Triterpenes / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D006027:Glycosides; D008055:Lipids; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C018642:polysponin; C047367:leontoside
vernacular_title: Vliianie leontozida i polisponina na funktsiiu shchitovidnoĭ zhelezy, lipidy i protivosvertyvaiushchuiu sistemu krovi krolikov s alimentarnoĭ giperkholesterinemieĭ.