Confidence limits for probability of response in multistage phase II clinical trials.
Herson (1979, Biometrics 35, 775-783) has given a method for designing one-arm k-stage phase II clinical trials, which permits early termination of the trial if the treatment is apparently ineffective, while retaining acceptable levels of power and significance. This paper gives a method for calculating the confidence limits on the response proportion, conditional on a particular study design.
D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D011336:Probability; D012107:Research Design