Projection of an endocoid involved with schizophrenic reaction.
Administration of 3,4-dimethoxyphenylethylamine, (DMPEA) which has been incubated with blood plasma from unmedicated, acute schizophrenics, to aggregated mice pretreated with the monoamine oxidase inhibitor, phenylisobutylhydrazine, has been shown to produce an amphetamine-like excitatory, lethal response in such mice. Use of blood plasma from 92 unmedicated, acute schizophrenics in the test system giving that response yielded 82 positive responses (89%) and 10 negative responses (11%). Substitution of the blood plasmas from 94 non-schizophrenics analogously into this test system produced 2 positive responses (2%) and 92 negative responses (98%). When plasma from schizophrenics medicated with antipsychotic tranquilizers were tested in the system, none gave positive response, 58 gave negative response. If the compound bis-N, N dimethoxyphenylethylamine (bis-DMPEA) was either added to DMPEA or substituted for it and incubated with inactive blood plasma taken from non-schizophrenics in the incubation step of the test system a marked positive response was elicited. The results obtained are compatible with a hypothesis which postulates function of a DMPEA metabolite as a pathologic endocoid in schizophrenic reaction.
D000208:Acute Disease; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004118:Dimethoxyphenylethylamine / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010627:Phenethylamines / Q000097:blood*; D010659:Phenylhydrazines / Q000494:pharmacology; D012016:Reference Values; D012559:Schizophrenia / Q000097:blood*
D004118:Dimethoxyphenylethylamine; D010627:Phenethylamines; D010659:Phenylhydrazines; C047131:phenylisobutylhydrazine