[Effect of diuretics on vascular permeability and proliferative inflammation in rats].
It is shown that ethacrynic acid and dichlothiazide in 50 mg/kg dose reduce the dextran-induced increase of rat skin vascular permeability. Besides, durable administration of furosemide, dichlothiazide and ethacrynic acid in 50-80 mg/kg doses decreases the dry mass of inflammatory granuloma. This fact shows the ability of diuretics to suppress the development of proliferative inflammation.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004976:Ethacrynic Acid / Q000494:pharmacology / Q000627:therapeutic use; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy*; D006852:Hydrochlorothiazide / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D012867:Skin / Q000098:blood supply / Q000187:drug effects
D004232:Diuretics; D006852:Hydrochlorothiazide; D005665:Furosemide; D004976:Ethacrynic Acid
Vliianie diuretikov na sosudistuiu pronitsaemost' i proliferativnoe vospalenie u krys.