title: Nutritional and toxicological effects of long-term ingestion of phosphine-fumigated diet by the rat.
abstract: The fumigation of stored foodstuffs with phosphine (PH3) is likely to become widely used in the future because of its technological efficiency and the rapid desorption of the fumigant. In a long-term feeding study of a phosphine-fumigated diet, rats were monitored for weight gain, food intake, plasma chemistry, haematology and urinary changes. Histopathological studies, including organ-weight determinations, were carried out after treatment of the rats for 1 and 2 yr. The results show that ingestion of a phosphine-fumigated diet by the rat for 2 yr does not cause any marked modification of growth, food intake, nitrogen balance, body composition, functional behaviour or the incidence or type of tumours.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005506:Food Contamination; D005651:Fumigation / Q000009:adverse effects*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009929:Organ Size / Q000187:drug effects; D010720:Phosphines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010720:Phosphines