[Quantitative DNA determination and its role in the prognosis of malignant tumors].
We summarize our own cytophotometric and flow cytometric measurements from malignant tumors and premalignant lesions. DNA, non-histoprotein and dry mass (by interference microscopy) have been assessed. Ploidy and the compartments of the cell cycle were evaluated. For most tumors (cervix, breast, ovary, melanoma, larynx, oro-facial, bladder) a bad prognosis was suggested by the following cytophotometric findings: aneuploidy, polyploidy, and/or a high proportion of S-G2/M nuclei. This has been statistically confirmed for breast cancer by case studies conducted over a period of five years. Among the changes associated with lung cancer were alterations in protein content. Cytophotometric findings can provide useful additional information concerning a patient's prognosis.
D002455:Cell Division; D002467:Cell Nucleus / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000032:analysis; D003592:Cytophotometry; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry; D006801:Humans; D007399:Interphase; D008207:Lymphatic Metastasis; D009369:Neoplasms / Q000032:analysis*; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm
Quantitative DNS-Bestimmung und ihre Rolle bei der Prognose maligner Tumoren.