Nasal symptoms in pseudoallergic reactions.
In a retrospective investigation 469 pseudoallergic reactions (analgesics asthma reactions) that emerged in 197 patients with analgesics intolerance have been analysed. Besides mostly severe asthma-attacks 26.5% of the reactions were sneeze-attacks and in 37.5% nasal secretion was found. 86% of the reactions emerged within a maximum of 45 minutes after oral application of the analgesic. About a third of the analgesics-asthma reactions occurs together with reactions of the nose mucous membrane. So the connection of analgesics-asthma and chronic hyperplastical changes of the mucous membrane of the upper respiratory tract is also reflected in the course of the pseudoallergic intolerance reaction.
D000700:Analgesics / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced; D004342:Drug Hypersensitivity / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D009297:Nasal Mucosa / Q000276:immunology*; D011720:Pyrazoles / Q000009:adverse effects; D047069:Pyrazolones; D012189:Retrospective Studies; D013997:Time Factors
D000700:Analgesics; D011720:Pyrazoles; D047069:Pyrazolones; C038362:pyrazolone; D001241:Aspirin