Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma.
Sixteen adults who had chronic asthma with nocturnal symptoms were selected to evaluate and compare the effectiveness of 7 A.M. versus 7 P.M. single daily dosing with the 24-hour sustained-release theophylline Uniphyl. The study was a randomized, double-blind, placebo-controlled trial in which the patients were given 800 mg of Uniphyl at either 7 A.M. or 7 P.M. for one week each. Serum theophylline levels showed significantly higher peak (18.1 +/- 1.8 micrograms/ml versus 12.7 +/- 1.2 microgram/ml) and trough (12.4 +/- 1.3 microgram/ml versus 7.6 +/- 1.0 microgram/ml) concentrations during evening dosing. Furthermore, daily peak flow values were higher in the morning when Uniphyl was given at 7 P.M. Thus, nocturnal dosing with Uniphyl gives higher serum theophylline concentrations and, with this, better control of nocturnal asthma.
D000328:Adult; D001066:Appetite / Q000187:drug effects; D001249:Asthma / Q000188:drug therapy*; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010366:Peak Expiratory Flow Rate; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood
D013806:Theophylline