title: Asymptotically efficient two-step estimators of the hazards ratio for follow-up studies and survival data.
abstract: Asymptotically efficient estimators of a common hazard rate ratio (for follow-up studies) and the proportional hazards ratio (for survival studies) are obtained by a single iteration of the "Mantel-Haenszel" estimator appropriate for each setting. Estimators of their variance are also developed. The two-step estimator for survival data and its variance estimator are shown by simulation to be minimally biased and the estimator is shown to be efficient relative to the Cox partial likelihood estimator in small samples.
mesh_terms: D001699:Biometry; D005500:Follow-Up Studies; D006801:Humans; D009026:Mortality; D012107:Research Design