S-adenosyl-L-methionine protection against alpha-naphthylisothiocyanate-induced cholestasis in the rat.
The effect of S-adenosyl-L-methionine (SAMe) on cholestasis induced by alpha-naphthylisothiocyanate (ANIT) was studied in rats. SAMe significantly attenuated both bile flow impairment and elevated values of serum bilirubin, glutamic pyruvic transaminase and alkaline phosphatase in ANIT-treated animals. These results suggest that SAMe protects the rat liver against the toxic effects of ANIT.
D015058:1-Naphthylisothiocyanate / Q000633:toxicity*; D000818:Animals; D001646:Bile / Q000032:analysis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002779:Cholestasis / Q000139:chemically induced / Q000517:prevention & control*; D008055:Lipids / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013861:Thiocyanates / Q000633:toxicity*
D008055:Lipids; D013861:Thiocyanates; D015058:1-Naphthylisothiocyanate; D012436:S-Adenosylmethionine