Effects of acetaldehyde and/or ethanol on neutral amino acid transport systems in microvillous brush border membrane vesicles prepared from human placenta.
At 20 mM of acetaldehyde, the activities of three transport systems of L-alanine distinguished by the differences in their cation dependence, namely 1) Na+-specific, 2) Li+-dependent, and 3) Na+-independent systems, were significantly reduced in a similar manner. Only the Li+-dependent system was selectively inhibited at toxic concentrations of acetaldehyde and ethanol.
D000079:Acetaldehyde / Q000494:pharmacology*; D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008094:Lithium / Q000494:pharmacology; D008567:Membranes, Artificial; D008871:Microvilli / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012964:Sodium / Q000494:pharmacology
D000596:Amino Acids; D008567:Membranes, Artificial; D000431:Ethanol; D008094:Lithium; D012964:Sodium; D000079:Acetaldehyde; D000409:Alanine