title: [Development of the methods for measuring drugs and their metabolites].
abstract: In therapeutic drug monitoring, the analyst is faced, like in clinical chemistry, with the problem of identification of drugs in the presence of a complex biological matrix. Precision, sensitivity and specificity are not such a problem as it was before and are achieved with mainly the aid of chromatographic separation and enzyme or antibody recognition.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D005453:Fluorescence; D007118:Immunoassay; D008163:Luminescent Measurements; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D012463:Saliva / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations
vernacular_title: Evolution des méthodes de dosage des médicaments et de leurs métabolites.