title: Efficiency of high permeable membranes in hemodiafiltration in children: an optimal method of purification.
abstract: Hemodiafiltration (HDF) combines hemodialysis (HD) and hemofiltration (HF) and so allows an optimal purification by combining diffusive process (low molecular weight compounds) with convective mass transport (middle molecular weight compounds). A high permeable membrane is analysed (clearance, extraction coefficient, sieving coefficient) at 30 min and 150 min session time in HD, HF and HDF conditions. There is not a better elimination of urea in HDF versus HD while HDF allows an optimal elimination of uremic toxins in the range of low and middle molecular weight compounds. A high (optimal?) filtrate flow, with a minimal risk, is given by the formula: QUF = 1/3 QB. Sieving coefficient in HF condition of the other membranes generally employed in pediatric HDF demonstrated a great variability for the cut off.
mesh_terms: D001783:Blood Flow Velocity; D002648:Child; D005630:Fructans / Q000378:metabolism; D006801:Humans; D008567:Membranes, Artificial; D008970:Molecular Weight; D006435:Renal Dialysis; D013997:Time Factors; D014462:Ultrafiltration
chemical_list: D005630:Fructans; D008567:Membranes, Artificial; C002938:polyfructosan