[Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A].
Deoxyadenylylguanosine (dAdG, 0.2-0.4 mM), affecting the RNA polymerase activity, caused inhibition of transcription of the influenza A virus in presence of precursor AdG by 50-60% and a 80-85% inhibition in absence of the precursor. The inhibitor exhibited its effect independently on the time of addition into an incubation mixture. Addition of 0.5 mM inhibitor into a cultural medium inhibited reproduction of the influenza A virus in a culture of chicken embryonal fibroblasts.
D000818:Animals; D002478:Cells, Cultured; D002645:Chickens; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D003838:Deoxyadenine Nucleotides; D003849:Deoxyguanosine; D009980:Influenza A virus / Q000201:enzymology* / Q000502:physiology; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D003838:Deoxyadenine Nucleotides; D009838:Oligodeoxyribonucleotides; C047743:deoxyadenylyl-(3'-5')-deoxyguanosine; D012321:DNA-Directed RNA Polymerases; D003849:Deoxyguanosine
Ingibiruiushchee deĭstvie dezoksiadenilil-(3'-5')-dezoksiguanozina na aktivnost' RNK-polimerazy virusa grippa A.