[Brain tumors in infants and children--factors affecting prognosis, (Part-3). Mode of metastasis and prognosis in medulloblastoma].
Brain tumors in infants and children are different from those in adults in type and location of tumor as well as accompanying complication. Given this fact, and the fact that these patients are under development, careful consideration is required for determination of treatment planning. Thus, we have investigated the curative results of brain tumors in infants and children and factors effecting prognosis. In this study, medulloblastoma which is one of the most malignant pediatric brain tumors was analyzed in 64 cases in light of mode of metastasis and prognosis. Among those cases, there were 23 cases which were diagnosed to have metastasis or infiltration of tumor from the original site of the fourth ventricle. As mode of the cerebrospinal fluid circulation, 6 intracerebral solitary metastasis, 1 entraspinal cord metastasis, 1 intraperitoneal metastasis via shunt and 7 generalized metastases involving bone in 5, lymphnodes in 2 and liver, spleen, kidney, lung and peintoneal cavity in 1 respectively. The survival rate in those 23 cases with tumor metastasis or infiltration was 63.6% in one year, 28.6% in two years and 11.8% in five years and the average survival year was 8.1 months in cases who died of these tumor metastasis. Six of them had tumor metastasis with in 6 months after the initial treatment(s). There was no significant correlations in rate or occurrence of tumor metastasis between group of total resection and of partial resection nor group of whole neuro-axis radiation and of local radiation.(ABSTRACT TRUNCATED AT 250 WORDS)
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology; D001933:Brain Stem; D002528:Cerebellar Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D007223:Infant; D008130:Lomustine / Q000008:administration & dosage; D008527:Medulloblastoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008727:Methotrexate / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D011379:Prognosis; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D008130:Lomustine; D008727:Methotrexate