Myocardial nutritional circulation in rabbits after doxorubicin injection.
The effect of doxorubicin on myocardial nutritional circulation in rabbits was determined by means of the isotopic [133Xe] method. The drug was injected iv in doses of 1, 3, and 6 mg/kg and the influence of doxorubicin on myocardial circulation was examined 1, 15, 30, 45, and 60 min after its administration. The results indicate that a single injection of doxorubicin produces an increase in myocardial nutritional circulation.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008297:Male; D009747:Nutritional Physiological Phenomena; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D004317:Doxorubicin