Polymorphism of C3 components and the B factor in patients with chronic renal failure, dialyzed iteratively.
The value of C3, of the cleavage C3 components and of the B factor were determined in 25 normal controls and in 22 patients with chronic renal failure (CRF), iteratively dialyzed. Low values of C3 and progressive hypomorphism of the cleavage components of C3 were observed in the patients at the three moments of determination. The activity of the B factor was also found significantly decreased in the patients. Our results indicated an activation of the complement alternative pathway in the dialyzed patients but the activation through the classic pathway, could not be excluded either. It is concluded that this activation might be due to the initial disease which generated CRF but also to some factors transported by hemodialysis.
D000328:Adult; D003176:Complement C3 / Q000032:analysis*; D003179:Complement C3b / Q000032:analysis*; D005260:Female; D006461:Hemolysis; D006801:Humans; D007122:Immunoelectrophoresis; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D003176:Complement C3; D003179:Complement C3b