[Effect of chronic hyperphenylalaninemia and hypoxia on the effectiveness of the alpha-ketoglutarate shunt in the brain].
The effects of hypoxia and chronic hyperphenylalaninaemia (HPA) on the intensity of the alpha-oxoglutarate shunt in rat brain after injection of [5-14C]glutamate were investigated. The reaction of reducing carboxylation of alpha-oxoglutarate was shown to be the rate-limiting step for the whole pathway. The deceleration of this reaction under chronic HPA or, conversely, its increase under short-term heavy hypoxia led to a corresponding decrease or increase of fatty acid synthesis in the brain with [5-14C]glutamate as a radioactive precursor.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002908:Chronic Disease; D002951:Citrates / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D007656:Ketoglutaric Acids / Q000378:metabolism*; D010649:Phenylalanine / Q000097:blood*; D010661:Phenylketonurias / Q000378:metabolism*; D051381:Rats
D002951:Citrates; D005971:Glutamates; D007656:Ketoglutaric Acids; D010649:Phenylalanine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vliianie khronicheskoĭ giperfenilalaninemii i gipoksii na éffektivnost' alpha-ketoglutaratnogo shunta v golovnom mozgu.