Identification of D-2 dopaminergic receptors in bovine adrenal cortex.
Dopamine receptors in bovine adrenal cortex have been studied by using 3H-(-)sulpiride as selective ligand. The specific binding is saturable and the Scatchard analysis reveals a single component with a Kd of 6.2 nM and a Bmax of 8 fmoles/mg protein. The characterization indicates that the binding is rapid, reversible, stereospecific, Na+ - and temperature- dependent. Moreover its pharmacological profile is superimposable to that of D-2 receptors in the striatum, thus suggesting that central and peripheral D-2 receptors are identical.
D000302:Adrenal Cortex / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D007700:Kinetics; D011954:Receptors, Dopamine / Q000378:metabolism*; D013237:Stereoisomerism; D013469:Sulpiride / Q000378:metabolism; D013696:Temperature
D011954:Receptors, Dopamine; D013469:Sulpiride; D006160:Guanosine Triphosphate