Ventricular arrhythmias induced in monkeys by the inhalation of aerosol propellants.
After inhaling fluoroalkane gases, which are used as aerosol propellants, some people have died suddently and unexpectedly. Seeking an explanation, we had 14 monkeys inhale these gases. All developed ventricular premature beats, bigeminy, or tachycardia, which began at an average of 39 (SE +/-4.2) sec. Fluoroalkanes were present in blood, but arterial hypoxemia or hypercapnia was absent, and arterial pressure was reduced only slightly. In contrast, without fluoroalkanes, 3 min of asphyxia or anoxia caused arrhythmias in only one monkey whose arterial oxygen tension had fallen to 16 mm Hg. The ventricular arrhythmias caused in well oxygenated monkeys by fluoroalkane gases may either be mediated through beta adrenergic receptors, since propranolol abolished these arrhythmias, or result from a nonadrenergic, direct, toxic effect of these gases on the heart. These results suggest that some deaths after propellant inhalation may be caused by ventricular tachycardia or fibrillation.
D000336:Aerosols; D000473:Alkanes / Q000008:administration & dosage / Q000506:poisoning; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D002245:Carbon Dioxide / Q000097:blood; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D000882:Haplorhini; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage / Q000506:poisoning*; D006863:Hydrogen-Ion Concentration; D008297:Male; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D011433:Propranolol / Q000494:pharmacology; D011941:Receptors, Adrenergic; D019966:Substance-Related Disorders; D013610:Tachycardia / Q000139:chemically induced; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000139:chemically induced
D000336:Aerosols; D000473:Alkanes; D006846:Hydrocarbons, Halogenated; D011941:Receptors, Adrenergic; D002245:Carbon Dioxide; D011433:Propranolol; D009584:Nitrogen; D010100:Oxygen