[Comparative study of the antigenic activity and allergic transformation of the body in human revaccination with different doses of a chemical brucellosis vaccine].
The study of different doses of chemical brucellosis vaccine (0.5 mg, 0.75 mg and 1 mg), used for the booster immunization of persons who had received primary immunization with chemical and live brucellosis vaccines, revealed that the characteristics of its antigenic potency were somewhat higher after primary immunization with the live vaccine. When used for booster immunization, the tested doses showed no differences in their antigenic potency irrespective of prior immunizations received by the immunized persons. In booster immunization chemical brucellosis vaccine was found to have poorly pronounced allergenic properties irrespective of its booster dose with the tendency towards greater sensitization to brucellosis allergen in persons primarily immunized with the live vaccine. When considering the possibility of using brucellosis chemical vaccine in medical practice, the complex evaluation of the characteristics showing its reactogenicity and antigenic potency, as well as the allergic transformation of the body induced by the injection of the vaccine, was carried out, which made it possible to recommend 1 mg of the vaccine as the optimal booster dose.
D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology*; D002002:Brucella / Q000276:immunology*; D002004:Brucella Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004341:Drug Evaluation; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007117:Immunization, Secondary; D012882:Skin Tests; D013997:Time Factors
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D002004:Brucella Vaccine
Sravinitel'noe izuchenie antigennoĭ aktivnosti i allergicheskoĭ perestroĭki organizma pri revaktsinatsii liudeĭ raznymi dozami brutselleznoĭ khimicheskoĭ vaktsiny.