[Distribution of the kinin-breakdown activity in areas of the rat brain in the dynamics of spontaneous hypertension].
Kinin-damaging activity (KDA) has been studied in 8 brain areas of normotensive rats and rats with spontaneous hypertension, aged 3 to 12 months. A significant depression in KDA was revealed in midbrain, striatum, thalamus, and pituitary body of normotensive rats 6 months of age, as compared to 3-month-old animals. A tendency towards KDA increase was noted in the hypothalamus. In 12-month-old normotensive rats KDA level returned to baseline (3 months of age). Comparison of KDA in rats with spontaneous hypertension aged 3 to 12 months has revealed no age-dependent differences and it is, therefore, believed that rats with spontaneous hypertension lack certain mechanisms inducing a considerable decrease of KDA in 6-month-old normotensive rats.
D000375:Aging; D000818:Animals; D001794:Blood Pressure; D001920:Bradykinin / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D006973:Hypertension / Q000201:enzymology*; D007705:Kinins / Q000378:metabolism*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D007705:Kinins; D001920:Bradykinin
Raspredelenie kininrazrushaiushcheĭ aktivnosti v zonakh mozga krys v dinamike spontannoĭ gipertonii.