[Enhancement of the antitumor effect of cyclophosphane in an experiment].
A significant antitumor effect of acetylcellulose microsphere-encapsulated cyclophosphamide was observed in the course of the studies carried out in 105 male Wistar rats bearing Walker's carcinosarcoma and PC-1 carcinoma. The effect is due to a high tissue level of the drug maintained for a long time as the drug uniformly passes through the porous microsphere wall. Local (intratumoral) treatment with cyclophosphamide is more effective than standard methods. The inhibitory effect of microsphere-enclosed cyclophosphamide on neoplastic growth is potentiated by tumor ischemia.
D000818:Animals; D002277:Carcinoma / Q000098:blood supply / Q000188:drug therapy / Q000401:mortality; D002279:Carcinoma 256, Walker / Q000098:blood supply / Q000188:drug therapy / Q000401:mortality; D002482:Cellulose / Q000031:analogs & derivatives; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D005263:Femoral Artery; D008026:Ligation; D008297:Male; D008863:Microspheres; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
C005062:acetylcellulose; D003520:Cyclophosphamide; D002482:Cellulose
Povyshenie protivoopukholevogo éffekta tsiklofosfana v éksperimente.