Effect of urea-hydrogen peroxide on hypoxia in rabbits.
PaO2 in hypoxemic rabbits was raised 30 min after intravenous administration of urea-hydrogen peroxide (U-H2O2). Peak levels appeared 2 h after administration of the drug and the effect continued up to 4 h. The treatment was effective and no side effects in the rabbits were observed. A new technique is described to produce hypoxemia in rabbits using a special mask. In contrast to previously described techniques the rabbits in this study could be kept alive with a stable hypoxemia for at least 4-5 h. This model may be useful for future studies requiring similar hypoxemic conditions in experimental animals.
D000818:Animals; D000077463:Carbamide Peroxide; D004195:Disease Models, Animal; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000494:pharmacology; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008397:Masks; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010545:Peroxides / Q000494:pharmacology*; D011817:Rabbits; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea; D005947:Glucose; D010100:Oxygen