Human serum as a culture medium for rat embryos.
A comparison was made between the development of post-implantation rat embryos in human serum and rat serum. Protein synthesis (growth) and somite number (differentiation) were retarded in human serum and there was an increased frequency of neural tube defects. Male and female human sera supported development equally well.
D000818:Animals; D001790:Blood Physiological Phenomena; D003470:Culture Media / Q000494:pharmacology; D005314:Embryonic and Fetal Development; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008297:Male; D009024:Morphogenesis; D009436:Neural Tube Defects / Q000209:etiology; D009924:Organ Culture Techniques / Q000379:methods*; D011506:Proteins / Q000032:analysis; D051381:Rats / Q000097:blood / Q000196:embryology*; D012107:Research Design; D012737:Sex Factors; D013045:Species Specificity
D003470:Culture Media; D011506:Proteins; D005947:Glucose