Role of autoantibodies in the autoimmune response to testis in rainbow trout (Salmo gairdneri).
Rainbow trout, Salmo gairdneri, passively immunized with anti-sperm antibodies developed lesions in the testis characteristic of autoimmune attack. Only animals pre-treated with Freund's complete adjuvant developed these lesions. Investigations into the possible role of autoantibodies during autoimmune attack, carried out in vitro, showed that sperm antibodies were not cytotoxic but did have an opsonic effect on macrophage phagocytosis of sperm in the presence of complement.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D007116:Immunization, Passive; D008264:Macrophages / Q000276:immunology; D008297:Male; D009895:Opsonin Proteins; D010587:Phagocytosis; D012487:Salmonidae / Q000276:immunology*; D013094:Spermatozoa / Q000276:immunology; D013737:Testis / Q000276:immunology*; D014337:Trout / Q000276:immunology*
D001323:Autoantibodies; D009895:Opsonin Proteins; D003165:Complement System Proteins