title: The clearance of gentamicin from antibiotic-loaded bone cement.
abstract: The concentrations of Gentamicin in the serum, drainage fluid and urine were determined by radioimmunoassay in 40 patients after total hip replacement and 10 after knee replacement. Palacos R bone cement with added Gentamicin had been used to fix the prostheses in all cases. Two types of response were observed; in Group I the Gentamicin levels rose very rapidly, whereas in Group II a more gradual increase was seen. In all cases the level of Gentamicin had fallen to a negligible amount by the fifth day after operation.
mesh_terms: D001843:Bone Cements / Q000378:metabolism*; D005839:Gentamicins / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006622:Hip Prosthesis / Q000379:methods; D006801:Humans; D007720:Knee Prosthesis / Q000379:methods; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000378:metabolism; D011184:Postoperative Period; D011863:Radioimmunoassay; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D001843:Bone Cements; D005839:Gentamicins; D008768:Methylmethacrylates; D020366:Methylmethacrylate