Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitro.
The effects of twenty-three natural cytochalasans and sixteen synthetic derivatives on actin-distribution and alteration in morphology of C3H-2K cells, inhibition of lymphocyte capping, and inhibition of actin filament elongation were compared. The effects on cellular level and the in vitro effects showed positive correlation and the structure-activity relationship observed is discussed.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002477:Cells / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003572:Cytochalasins / Q000494:pharmacology*; D007152:Immunologic Capping / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D011108:Polymers; D011817:Rabbits; D013329:Structure-Activity Relationship
D000199:Actins; D003572:Cytochalasins; D011108:Polymers