title: [Mechanism of action of noradrenaline on cutaneous thermoreceptors].
abstract: The comparison of intradermal temperature, oxygen consumption and the rectal temperature with the skin cold-sensitive receptor responses to intraperitoneal and intraarterial noradrenaline injections shows that non-temperature changes following the increasing heat production or changing skin vessel tension are unrelated to augmentation of static receptors activity with rise of the noradrenaline concentration in the blood. It is possible that noradrenaline acts directly on thermoreceptors membrane. Apparently noradrenaline and sympathetic nervous system modulate the activity of the skin cold-sensitive receptors activity.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D007269:Injections, Intra-Arterial; D007274:Injections, Intraperitoneal; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010101:Oxygen Consumption; D051381:Rats; D012867:Skin / Q000294:innervation; D012881:Skin Temperature / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000502:physiology; D013823:Thermoreceptors / Q000187:drug effects* / Q000502:physiology
chemical_list: D009638:Norepinephrine
vernacular_title: O mekhanizme deĭstviia noradrenalina na kozhnye termoretseptory.