title: [Structure-activity relationship in the series of muscarinic acetylcholine receptor agonists: three types of agonist-receptor complexes].
abstract: A new procedure has been applied to analyze the data available in literature on the structure-activity relationships for agonists of the muscarinic acetylcholine receptor. The agonists were subdivided into three groups, each containing the compounds with the specific structural element. The binding constant logarithms, characterizing the agonist association with the receptor, increase linearly with the increase in the partition coefficient logarithms describing the distribution in the water-octanol system. The performed analysis suggests the existence of three different types of agonist-receptor complexes.
mesh_terms: D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D007700:Kinetics; D008954:Models, Biological; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000378:metabolism / Q000494:pharmacology; D010277:Parasympathomimetics / Q000378:metabolism* / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D010276:Parasympatholytics; D010277:Parasympathomimetics; D011976:Receptors, Muscarinic
vernacular_title: Vzaimosviaz' struktury i aktivnosti f riadu agonistov muskarinovogo atsetilkholinovogo retseptora: tri tipa kompleksov agonistov s retseptorom.