High-pressure liquid chromatographic determination of thioridazine and its major metabolites in biological tissues and fluids.
A method is described for the determination of thioridazine and its major metabolites in postmortem tissues and fluids by enzymic digestion, followed by a micro-extraction technique using ethyl acetate. Quantitation was performed by using a cyano-bonded silica (mu Bondapak-CN) column packing and a mobile phase consisting of n-octylamine, methanol, and water.
D001711:Biotransformation; D001826:Body Fluids / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007202:Indicators and Reagents; D013881:Thioridazine / Q000032:analysis* / Q000378:metabolism / Q000506:poisoning
D007202:Indicators and Reagents; D013881:Thioridazine