title: Toxic factors limiting the use of anticancer agents.
abstract: Anticancer agents are administered at toxic doses to achieve maximum tumor cell kill. In addition to rapidly proliferating tissues such as bone marrow, the subsequent toxicities may involve the heart, liver, lungs, kidneys and other organs. Exploration of noncytotoxic mechanisms of anticancer activity may provide safer cancer chemotherapy.
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D009369:Neoplasms / Q000139:chemically induced; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents