[Characteristics of the correction of the blood aggregate condition during extracorporeal hemosorption in hematologic patients].
The authors described experience in the use of the method of extracorporal hemosorption in patients with grave hemoblastoses. Nineteen of them were given 24 hemosorptions. Though severe disorders of the blood aggregate condition, thrombocytopenia (65%) and signs of disorder of thrombocyte function were present, no hemorrhagic complications during hemosorption were observed. Mean doses of heparin taking account of its consumption for sorbent treatment were 200 I.U./kg of body mass in thrombocytopenia and 300 I.U./kg of body mass with the normal level of thrombocytes. The refusal of protamine-sulfate administration to neutralize residual heparin at the end of operation for fear of possible complications made it possible to restore the initial indices of homeostasis 20 hrs. after sorption. This scheme for examination of the homeostasis system made it possible to control the adequacy of patient's heparinization and to avoid complications of the blood coagulation system.
D001777:Blood Coagulation / Q000187:drug effects*; D006464:Hemoperfusion; D006470:Hemorrhage / Q000517:prevention & control; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000628:therapy*; D009101:Multiple Myeloma / Q000097:blood / Q000628:therapy*; D010974:Platelet Aggregation / Q000187:drug effects*; D013927:Thrombosis / Q000517:prevention & control
D006493:Heparin
Osobennosti korrektsii agregatnogo sostoianiia krovi pri ekstrakorporal'noĭ gemosorbtsii u gematologicheskikh bol'nykh.