Effect of organic and inorganic mercury compounds on the growth of incisor and tibia in rats.
The pharmacological effects of methyl mercury chloride (MMC) and mercuric chloride (HgCl2) (2-16 mg/Kg per day subcutaneously, for 6 d) upon the growth were studied in the incisors and proximal tibiae of immature rats histologically. Lead acetate was used as a time marker. 1. Mercury compounds slightly affected the body weight gains of the rats but apparently inhibited the longitudinal growth of proximal tibia and the effect increased with higher dosages. 2. Mercury compounds definitely inhibited not only the longitudinal growth (incisor growth) but also the appositional growth (dentin formation) of incisal dentin. 3. The inhibitory effect on the growth was ranked as follows: bone growth greater than dentin formation greater than incisor growth. 4. The actions of MMC on the growth of incisors and proximal tibiae appeared gradually and the response was biphasic; stimulatory and then inhibitory. The inhibitory effect appeared even after the injection was discontinued and appeared more extremely than during the injections. 5. In HgCl2 groups the inhibitory effect on the growth appeared rapidly. The effect increased with higher dosages and became stronger as the injections were repeated. However, this effect was weakened promptly after the injection was discontinued. 6. The repeated injections of mercury compounds hardly affected the level of serum calcium but disturbed the calcification of incisal dentin. From the above-mentioned results a possible mechanism was discussed. It is suggestive that MMC acts directly upon a cell and is transported into it. Once MMC was introduced into a cell it is slowly demethylated to inorganic Hg and acts as the demethylated mercury. When accumulated mercury is slight in volume, it stimulates and then inhibits the cell function with increasing mercury. However HgCl2 binds directly with an effector cell membrane in loose fashion. This may cause the ready reversibility of the effect.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D007180:Incisor / Q000187:drug effects* / Q000254:growth & development; D007275:Injections, Intravenous; D007854:Lead / Q000008:administration & dosage; D008297:Male; D008627:Mercuric Chloride / Q000009:adverse effects*; D008767:Methylmercury Compounds / Q000009:adverse effects; D009941:Organomercury Compounds / Q000009:adverse effects*; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D013977:Tibia / Q000187:drug effects* / Q000254:growth & development
D008767:Methylmercury Compounds; D009941:Organomercury Compounds; D009942:Organometallic Compounds; D007854:Lead; D008627:Mercuric Chloride; C004925:methylmercuric chloride; C008261:lead acetate