Diuretic agents related to indapamide. II. Synthesis and pharmacological activity of 1-alkyl, 1-carboxyalkyl- and 1,3-dialkyl substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines.
In pursuing earlier studies, the synthesis of a series of 1 and 1,3- substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines (V a-e), related to indapamide, is described. These compounds were evaluated for diuretic and antihypertensive activities.
D000818:Animals; D000959:Antihypertensive Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D004573:Electrolytes / Q000378:metabolism; D007190:Indapamide / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013997:Time Factors
D000959:Antihypertensive Agents; D004232:Diuretics; D004573:Electrolytes; D007190:Indapamide