Ascorbic acid stability in aqueous solutions.
Different water purity provokes a great variation of the stability of ascorbic acid and isoascorbic acid solutions. The effect of temperature on ascorbate aerobic oxidation was assessed by means of Arrhenius plots from which thermodynamic parameters were derived. The presence of bovine serum albumin drastically reduces the vitamin oxidation rate regardless of stereoisomerism. On the other hand the interaction with alkaline phosphatase, an enzyme inhibited by preincubation with vitamin C, does not modify significantly the stability in the experimental conditions used.
D000469:Alkaline Phosphatase; D001205:Ascorbic Acid; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D010084:Oxidation-Reduction; D012710:Serum Albumin, Bovine; D013237:Stereoisomerism; D013696:Temperature; D013816:Thermodynamics; D014867:Water
D014867:Water; D012710:Serum Albumin, Bovine; D000469:Alkaline Phosphatase; D001205:Ascorbic Acid