Deficits in cholinergic enzyme activities in septo-temporal regions of the senescent rat hippocampus, and in the forebrain of aged mice: effect of chronic Hydergine treatment.
Choline acetyltransferase and acetylcholinesterase activities in the septo-temporal regions of the rat hippocampus, and in the forebrain of mice were significantly decreased in senescent as compared with adult animals. A four week treatment of aged rats or mice with Hydergine resulted in the restoration of choline acetyltransferase activity.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011916:Rats, Inbred F344
D004088:Dihydroergotoxine; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase