Stability of procaine hydrochloride in a cardioplegic solution containing bicarbonate.
The influence of preparation methodology and storage conditions on pH and procaine stability, in a cardioplegic solution, was studied. A solution prepared with carbon dioxide in the head space and stored at -10 degrees C showed acceptable stability.
D001639:Bicarbonates / Q000032:analysis*; D002122:Calcium Chloride / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006207:Half-Life; D006324:Heart Arrest, Induced; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000032:analysis*; D011189:Potassium Chloride / Q000032:analysis*; D011343:Procaine / Q000032:analysis*; D012965:Sodium Chloride / Q000032:analysis*; D013997:Time Factors
D001639:Bicarbonates; C041711:St. Thomas' Hospital cardioplegic solution; D012965:Sodium Chloride; D011343:Procaine; D011189:Potassium Chloride; D008274:Magnesium; D002122:Calcium Chloride