[Effect of isoptin and euphylline on calcium- and carbacholine-induced contractile activity of isolated intestinal strips of rats of various ages].
It has been shown on isolated strips of the large intestine of adult and 2-week-old rats that the potassium depolarized smooth muscle of the adult rat intestine reacts by contractions to less concentrations of Ca2+ as compared to 2-week-old rats. Euphylline blocked the reaction of the adult rat large intestine to Ca2+ more powerfully than isoptin. The effects of the spasmolytics on 2-week-old rats were less demonstrable in view of the unremarkable reaction to Ca2+ itself. Both agents reduced the reaction of the adult rat large intestine strips to carbacholine more intensely as compared with 2-week-old rats.
D000367:Age Factors; D000818:Animals; D002122:Calcium Chloride / Q000037:antagonists & inhibitors; D002217:Carbachol / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D007420:Intestine, Large / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology*
D002217:Carbachol; D013806:Theophylline; D014700:Verapamil; D002122:Calcium Chloride
Vliianie izoptina i eufillina na sokratitel'nuiu aktivnost' izolirovannykh otrezkov kishki krys raznogo vozrasta, vyzvannuiu kal'tsiem i karbakholinom.