title: The effect of exposure duration on the blood level of glucose, pyruvate and lactate in acute carbon monoxide intoxication in man.
abstract: Blood glucose, pyruvate and lactate were examined during hospitalization of 13 cases of acute carbon monoxide poisoning developing from short (less than or equal to 1.5 h) or long (10-14 h) exposure. CO intoxication resulted in increased blood levels of all carbohydrate metabolites studied. Increased levels of pyruvate and lactate were much more pronounced and lasted for a longer time following long, compared with short, CO exposure despite similar blood COHb level (about 40% at the beginning of hospitalization). The results showed difference in biochemical effect of short and long single exposure to CO that could not be detected by the measurement of COHb.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002249:Carbon Monoxide Poisoning / Q000097:blood*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid; D002263:Carboxyhemoglobin