[Structural changes in the liposomes and the lamellar packing of liposomal lipids exposed to glycerin].
Glycerol-induced structural changes in multilamellar liposomes (ML) were studied by light and thin-section electron microscopy. It is shown that high concentrations of glycerol induce non-bilayer rearrangements of liposomal lipids in ML. The data obtained are discussed regarding the possible mechanisms of cryoprotector effects on natural (biological) and artificial (liposomal) membranes.
D000818:Animals; D004347:Drug Interactions; D005990:Glycerol / Q000494:pharmacology*; D008051:Lipid Bilayers / Q000032:analysis* / Q000494:pharmacology; D008081:Liposomes / Q000032:analysis* / Q000494:pharmacology; D008563:Membrane Lipids / Q000032:analysis* / Q000494:pharmacology; D008854:Microscopy, Electron; D013535:Suspensions; D013997:Time Factors
D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids; D013535:Suspensions; D005990:Glycerol
Izmenenie struktury liposom i lamelliarnoĭ upakovki liposomal'nykh lipidov pri vozdeĭstvii glitserina.