title: The neurobehavioral effects of pralidoxime mesylate in the rat.
abstract: The neurobehavioral effects of pralidoxime mesylate (P2S) were characterized in the rat by comparing standard measures such as conditioned taste aversion, operant behavior and spontaneous locomotor activity. Male albino Sprague-Dawley rats were injected IP with either saline, 25, 50, or 100 mg/kg of P2S. None of these doses produced any overt toxic effects. P2S produced a conditioned taste aversion at the highest dose (100 mg/kg) using a single conditioning trial with sucrose in a one-bottle test. Acute administration of 100 mg/kg did not disrupt fixed ratio responding on a water reinforced schedule. All three doses, 25, 50, and 100 mg/kg, decreased spontaneous locomotor activity in a dose-dependent manner. The results of these studies support the findings that a single injection of P2S at the therapeutic levels would not disrupt the normal working performance in man.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects*; D011220:Pralidoxime Compounds / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects
chemical_list: D011220:Pralidoxime Compounds; C028797:pralidoxime