title: Meiosis II, mitosis I and the linking interphase: a study of the cytoskeleton in the fertilised mouse egg.
abstract: Data concerning the organisation and the role of microtubules and microfilaments during the 20 h following fertilisation in vitro of the mouse oocyte is reviewed. This period covers the fertilisation-induced completion of meiosis, from second meiotic metaphase through the first mitotic cell cycle, and involves the union of the haploid parental genomes. Various antibodies were used against actin, tubulin and PCM to describe the localisation of the cytoskeletal components and the two cytoskeleton-disrupting drugs nocodazole and CCD to assess the functional importance of the cytoskeleton.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002875:Chromosomes / Q000648:ultrastructure; D015638:Cytochalasin D; D003572:Cytochalasins / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects / Q000648:ultrastructure*; D004261:DNA Replication / Q000187:drug effects; D005306:Fertilization / Q000187:drug effects; D007399:Interphase; D008540:Meiosis; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D015739:Nocodazole; D009685:Nuclear Envelope / Q000502:physiology; D009865:Oocytes / Q000648:ultrastructure*; D013997:Time Factors; D014404:Tubulin / Q000378:metabolism
chemical_list: D001562:Benzimidazoles; D003572:Cytochalasins; D014404:Tubulin; D015638:Cytochalasin D; D015739:Nocodazole