Failure of cyclo (His-Pro) to exhibit natriuretic activity.
Administration of exogenous cyclo (His-Pro) to dogs has been reported to elicit natriuresis. In contrast, our data fail to show any natriuretic activity of cyclo (His-Pro) in dogs or rats. The possible reasons underlying this discrepancy are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013045:Species Specificity; D013997:Time Factors
D010456:Peptides, Cyclic; D010879:Piperazines; D012964:Sodium; C015924:histidyl-proline diketopiperazine; D011188:Potassium