title: [Characteristics of the effect of piracetam on liver-mitochondrial respiration in intact and gonadectomized rats of both sexes].
abstract: It has been established in experiments on rats that subcutaneous administration of piracetam for 6 days in a daily dose of 100 mg/kg produces in intact but not in gonadectomized animals the following alterations in the system of oxidation and energetic coupling of liver mitochondria: a decrease in the magnitude of the respiratory control according to Chance, elevation of the rate of oxidation of NAD+-dependent substrates, a decrease in the stimulation of the rates of substrate oxidation by a disconnector, a rise of the rate of exogenous NADH oxidation by the amytal-antimycin A-resistant pathway. The action of piracetam described is pronounced to a greater degree in females than in males.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009919:Orchiectomy; D010052:Ovariectomy; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D012737:Sex Factors
chemical_list: D011760:Pyrrolidinones; D009243:NAD; D010889:Piracetam
vernacular_title: Osobennosti deĭstviia piratsetama na dykhanie mitokhondriĭ pecheni u krys raznogo pola (intaktnykh i v usloviiakh gonadektomii).