title: [Severe early-onset thrombopenia induced by non-fractionated heparin: therapeutic trial with low molecular weight heparin].
abstract: A case of severe thrombocytopenia (27 x 10(3)/mm3) of early onset during unfractionated heparin (Héparine sodique Rovi) treatment is reported in a 75 year-old man suffering from a deep vein thrombosis of the right calf. It was not associated with thromboembolic or haemorrhagic complications. A serum heparin-dependent aggregating factor was not detected. Substitution of low molecular weight heparin (Choay Laboratory, CY 222, PM 4 500, 25 000 U anti-Xa/ml) for unfractionated heparin resulted in a progressive normalisation of the platelet count and improvement of the venous thrombosis.
mesh_terms: D000368:Aged; D006493:Heparin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000188:drug therapy
chemical_list: D006493:Heparin
vernacular_title: Thrombopénie sévère précoce induite par l'héparine non fractionnée: tentative thérapeutique par une héparine de bas poids moléculaire.