title: [Experimental histopathological studies of electrical callus formation and mechanism of bone healing by direct micro-electrical current].
abstract: In order to get better understanding of the effects of electrical stimulation on bone healing processes, the author compared the healing processes of the femur in dogs between two groups: a stimulation group and a control group (non-stimulation group) which were experimentally prepared. These bone specimens were periodically extirpated and used for pathological examinations and X-ray micro-analysis. In the stimulation group, strong proliferation of osteoblasts and new trabecular formation in the bone marrow were observed at the 3rd day, and transition from fibrous to bony callus were noted at the 9th day; after the 3rd week bone remodeling was sparsely seen and bone healing period was shortened. In electromicroscopic observation, calcification of bone matrix and bone remodeling also seemed to be facilitated in this group. However, no marked differences in histological process of bone healing were observed between the stimulation group and the control group.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000502:physiology* / Q000648:ultrastructure; D002146:Bony Callus / Q000502:physiology*; D002113:Calcification, Physiologic; D002454:Cell Differentiation; D004285:Dogs; D004558:Electric Stimulation / Q000295:instrumentation / Q000379:methods; D008297:Male; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology; D014945:Wound Healing