[Synthesis of prednicarbate, an non-halogenated topical anti-inflammatory derivative of prednisolone-17-ethylcarbonate esters].
The synthesis of prednisolone-17-ethylcarbonate-21-propionate (5) (prednicarbate, Hoe 777) passing the intermediate products prednisolone-17,12-diethylorthocarbonate (2) and prednisolone-17-ethylcarbonate (3) as well as some physicochemical properties and spectroscopic data of (5), especially the 1H-NMR- and MS-spectrum, are reported. Prednicarbate has an optimal split of topical/systemic antiinflammatory activity.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000893:Anti-Inflammatory Agents; D011239:Prednisolone
Synthese von Prednicarbat, einem halogenfreien, topisch antiinflammatorisch wirksamen Derivat des Prednisolon-17-ethylkohlensäureesters.