[Effect of changes in the oxygen level on cholesterol esterase activity of the liver of intact rats and rats subjected to chronic hypoxia].
Alterations in activity of cholesterol esterases from lysosomal, microsomal and cytoplasmic cell fractions of rat liver tissue were studied under conditions of acute and chronic hypoxia and hyperoxia. Activity of the membrane-bound lysosomal and microsomal cholesterol esterases was decreased but the cytoplasmic enzyme was activated in acute hypoxia and hyperoxia. These data suggest that the enzymes, responsible for alterations in the ratio free cholesterol/cholesterol esters in cells, are dependent on the level of oxygen consumption.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D003593:Cytoplasm / Q000201:enzymology; D000860:Hypoxia / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D002787:Sterol Esterase / Q000378:metabolism*
D002265:Carboxylic Ester Hydrolases; D002787:Sterol Esterase
Vliianie izmeneniĭ kislorodnogo rezhima na aktivnost' kholesterolésteraz pecheni intaktnykh i podvergnutykh khronicheskoĭ gipoksii krys.