title: Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis.
abstract: Breast enlargement is an unusual complication of D-penicillamine therapy for rheumatoid arthritis. We observed breast enlargement and hyperprolactinemia in a woman receiving D-penicillamine for systemic sclerosis. Treatment with danazol was associated with a reduction in both the breast size and the prolactin level.
mesh_terms: D000368:Aged; D001940:Breast / Q000187:drug effects*; D003613:Danazol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000188:drug therapy; D010396:Penicillamine / Q000009:adverse effects*; D012595:Scleroderma, Systemic / Q000188:drug therapy*
chemical_list: D010396:Penicillamine; D003613:Danazol