Possible role of 4',4''-diethylstilbestrol quinone in diethylstilbestrol carcinogenesis.
4',4''-Diethylstilbestrol quinone, an intermediate in diethylstilbestrol metabolism, had previously been postulated to play a role in diethylstilbestrol-induced carcinogenesis. Possible mechanisms by which 4',4''-diethylstilbestrol quinone may participate in the induction of tumors by diethylstilbestrol are discussed. The possibilities of a direct modification of cellular macromolecules by the quinone intermediate and also an indirect involvement via generation of radicals are explored.
D001711:Biotransformation; D002273:Carcinogens; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D009696:Nucleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D011809:Quinones / Q000633:toxicity*; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009696:Nucleic Acids; D011809:Quinones; C039998:diethylstilbestrol quinone; D004054:Diethylstilbestrol