[Disorder of Ca2+ deposition in the myocardial mitochondria and sarcoplasmic reticulum in sudden death from ischemic heart disease].
The content of Ca2+ was reduced in myocardiocyte mitochondria and sarcoplasmatic reticulum, and increased in the supra-sedimentary fluid following the sedimentation of sarcoplasmatic reticulum in cases of sudden coronary death, an evidence of disturbed Ca2+ deposition in subcellular myocardial fractions and elevated Ca2+ concentration in myocardiocyte sarcoplasm. The demonstrated disturbances of Ca2+ deposition may be responsible for cardiac contractility disorders, and incomplete diastolic relaxation of the myocardium, and thus provide an essential element of thanatogenesis of the sudden coronary death.
D002118:Calcium / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism*; D003645:Death, Sudden / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*; D014947:Wounds and Injuries / Q000378:metabolism
D002118:Calcium
O narushenii deponirovaniia Ca2+ v mitokhondriiakh i sarkoplazmaticheskom retikulume miokarda pri vnezapnoĭ smerti ot ishemicheskoĭ bolezni serdtsa.