[Effect of flunarizine on healing and necrosis of experimental autografts in the rat].
The influence of flunarizine on flap necrosis has been studied in rats by means of an abdominal neurovascular island skin flap model. Four groups of six rats were treated in a pretreatment phase of one week and a medication phase of four weeks with either flunarizine (2.5 mg/kg) or a placebo. Rats with flunarizine treatment over the whole period showed a significantly faster healing and less necrosis than the placebo group. The group without flunarizine pretreatment showed similar results as the control group at the first week after surgery, but from the second week on, the flunarizine effect became manifest. The skin graft model clearly demonstrates the beneficial effects of flunarizine in the prevention of tissue necrosis.
D000818:Animals; D002936:Cinnarizine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005444:Flunarizine; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps; D014665:Vasodilator Agents / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D014665:Vasodilator Agents; D002936:Cinnarizine; D005444:Flunarizine
Einfluss von Flunarizin auf Einheilung und Nekrose von experimentellen Autotransplantaten bei Ratten.