Prostate cancer in a Sprague-Dawley rat.
An adenocarcinoma of the prostate gland developed in one rat of the Lobund Sprague-Dawley (S-D) strain, following treatments with testosterone propionate in silastic membranes. The transplanted cells (PA-SD1) developed local tumors, metastasized through lymphatic channels to the lungs, and induced osteolytic lesions when deposited adjacent to the calvarium. In vitro-propagated PA-SD1 cells produced the same tumor type in Lobund strain S-D rats as that from which it was derived.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone
D013739:Testosterone