[Interaction of tripeptides containing arginine and tyrosine (or phenylalanine) residues with synthetic polynucleotides and DNA of various origins].
Model peptides--L-Arg-Gly-L-Arg, L-Arg-L-Tyr-L-Arg and L-Arg-L-Phe-L-Arg bind to different DNAs and synthetic polynucleotides and are found in the major groove of the double helix. Polynucleotide complexes containing L-Arg-Gly-L-Arg were studied in order to consider the influence of the arginine residues on the polynucleotide melting temperature. It was shown, that L-Arg-L-Tyr-L-Arg and L-Arg-L-Phe--L-Arg lowers the melting temperature in all polynucleotides studied. The dependence of the melting temperature of polynucleotide (DNA)--L-Arg-L-Tyr(L-Phe)-L-Arg complexes upon the polynucleotide GC-content has been detected. These effects reflect the intercalation of peptide tyrosyl (or phenylalanyl) residues into the double-stranded polynucleotide.
D001120:Arginine; D004247:DNA; D004269:DNA, Bacterial; D004279:DNA, Viral; D046911:Macromolecular Substances; D009691:Nucleic Acid Denaturation; D009842:Oligopeptides; D010649:Phenylalanine; D011067:Poly dA-dT; D011089:Polydeoxyribonucleotides; D011489:Protein Denaturation; D014443:Tyrosine
D004269:DNA, Bacterial; D004279:DNA, Viral; D046911:Macromolecular Substances; D009842:Oligopeptides; D011089:Polydeoxyribonucleotides; D011067:Poly dA-dT; C019530:poly(dC-dG); D014443:Tyrosine; D010649:Phenylalanine; C028333:poly(d(A-C).d(G-T)); D004247:DNA; D001120:Arginine
Issledovanie vzaimodeĭstviia tripeptidov, soderzhashchikh ostatki arginina i tirozina (ili fenilalanina), s sinteticheskimi polinukleotidami i DNK razlichnogo proiskhozhdeniia.