Activation of the impaired nasal mucociliary transport in children: preliminary report.
The effect of HR-6 containing adenosine triphosphate on the impaired mucociliary transport was studied in 13 children. The main symptoms in the children were chronic non-allergic rhinitis, recurrent otitis media, recurrent or chronic maxillary sinusitis and infections of the lower respiratory tract. Initially, the mucociliary transport rate ranged from 0 to 5.6 mm/min, mean 1.8 mm/min. HR-6 increased the mucociliary transport rate by 1.3-3.5, mean 2.0 mm/min. The corresponding figures for the placebo were from 0 to 0.4, mean 0.2 mm/min. These preliminary results indicate further studies with HR-6 in children with impaired mucociliary function are necessary.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000293:Adolescent; D001692:Biological Transport / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002923:Cilia / Q000187:drug effects / Q000378:metabolism*; D002925:Ciliary Motility Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009093:Mucus / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D000255:Adenosine Triphosphate