[Changes in the permeability of the blood-brain barrier to oxythiamine].
Activity of transketolase was distinctly inhibited in mice brain after simultaneous administration of hydroxythiamine and 3,3-dimethyl-l-phenyl-l-phthalyl acetic acid. The rate of the enzyme inhibition correlated with an increase of the acid concentration in the mixture studied. The data obtained suggest that permeability of blood-brain barrier for hydroxythiamine was altered in simultaneous administration of the vitamin with some biologically active preparations.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D008297:Male; D051379:Mice; D010119:Oxythiamine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D010539:Permeability; D013844:Thiazoles / Q000494:pharmacology*; D014174:Transketolase / Q000037:antagonists & inhibitors
D013844:Thiazoles; D010119:Oxythiamine; C047745:3-(2,2-dichlorodiethyl)aminopropionic acid oxythiamine ester; C047744:3,3-dimethyl-1-phenyl-1-phthalylacetic acid oxythiamine ester; D014174:Transketolase
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