title: [Synthesis and analgesic activity of 3-substituted derivatives of pyrido [3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-ones].
abstract: A series of Schiff bases of 3-amino-2,7,9-trimethylpyrido-[3',2',:4,5]thieno[3,2-d]pyrimidin- 4(3H)-one with aromatic aldehydes was synthesized. The compounds showed interesting analgesic activity without effects on the stomach even with oral doses of 200 mg/kg.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D013272:Stomach Diseases / Q000139:chemically induced; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000700:Analgesics; D011725:Pyridines; D011744:Pyrimidinones; D012545:Schiff Bases; D013876:Thiophenes
vernacular_title: Sintesi ed attività analgesica di derivati pirido[3',2':4,5]tieno[3,2-d]pirimidin-4(3H)-oni 3-sostituiti.