The use of two alpha blocking agents, phenoxybenzamine and phentolamine, in ointment and injection form to improve skin flap survival in rats.
Two alpha blocking agents, phenoxybenzamine and phentolamine, were tested to see if their use improved skin flap survival in rats. The agents were used in two ways: in local injections and topical applications. The results showed an increased duration of flap viability with both modalities, but the topical application was the most effective.
D000287:Administration, Topical; D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D009824:Ointments; D010643:Phenoxybenzamine / Q000008:administration & dosage / Q000627:therapeutic use*; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
D009824:Ointments; D010643:Phenoxybenzamine; D010646:Phentolamine