title: Plasma calcium control in the rat fetus. III. Influence of alterations in maternal plasma calcium on fetal plasma calcium level.
abstract: Acute maternal alterations in plasma calcium were used as an indirect mean to study the placental transfer of calcium in thyroparathyroidectomized (TPTX) pregnant rats. Calcium infusions to normal or TPTX females showed in both cases a saturation mechanism reflected on fetal plasma calcium. With TPTX mothers saturation curves of the fetal plasma calcium were similar whether fetuses were decapitated (deprived of brain, hypophysis, and thyroparathyroid complex) or intact. Increments in fetal plasma calcium were 4-fold higher in TPTX mothers (approximately 2.5 mg/dl), and 2-fold higher in thyroidectomized (TX) mothers (approximately 0.5 mg/dl). From the whole results, it appeared that increments in fetal plasma calcium secondary to maternal calcium infusion were probably related to the basal plasma calcium in the fetus, and not to the hormonal deficiency of the mother.
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000502:physiology; D002118:Calcium / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D010280:Parathyroid Glands / Q000601:surgery; D010281:Parathyroid Hormone / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D002116:Calcitonin; D013974:Thyroxine; D002118:Calcium