title: The effect of nerve activity on the distribution of synaptic vesicles.
abstract: Certain gymnotid fish (apteronotids) continuously emit a high-frequency electric-organ discharge and thus continuously drive their electroreceptor afferents at high rates. Electroreceptor afferents terminate in one lamina of the electrosensory lateral line lobe (ELL) and can be readily sampled. Normally these terminals have many small vesicles clustered adjacent to the presynaptic membrane. When afferent activity is blocked for 24 hr by an injection of tetrodotoxin (TTX) into the electroreceptor nerve, the density of vesicles adjacent to the synaptic membrane declines; the volume of the remaining vesicles increases. If the nerve of a TTX-treated fish is stimulated proximal to the injection site, these changes can be reversed. These results imply that the migration of vesicles toward the presynaptic membrane is influenced by the level of activity in the nerve.
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005399:Fishes / Q000502:physiology*; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000502:physiology / Q000648:ultrastructure; D009431:Neural Conduction / Q000187:drug effects; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D011984:Sensory Receptor Cells / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology* / Q000648:ultrastructure; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin