Glycolytic origin of alanine formed in rat diaphragm muscle in vitro.
In quarter-diaphragms from 40 h-starved rats the rate of glycogen mobilization is sufficient to account for the rate of lactate+pyruvate+alanine production. It is concluded, therefore, that alanine derives its carbon skeleton predominantly via glycolysis and not via synthesis de novo from tricarboxylic acid-cycle intermediates and related amino acids.
D000409:Alanine / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D000818:Animals; D003964:Diaphragm / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D066298:In Vitro Techniques; D008297:Male; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000378:metabolism
D000597:Amino Acids, Branched-Chain; D006003:Glycogen; D000409:Alanine