title: [Comèl's ichthyosis linearis circumflexa: treatment with Ro 10-9359. Electron microscopic study].
abstract: The authors show the noteworthy efficacy of the aromatic retinoid Ro 10-9359 in the treatment of ichthyosis linearis circumflexa. The initial dose was 1 mg/kg daily; later on, the maintenance dose was 0.3 mg/kg daily. Ultrastructurally, transitional cells were observed between the granular and the horny layer. After treatment, large perinuclear pseudovacuoles appeared, as well as numerous microvilli.
mesh_terms: D000328:Adult; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000648:ultrastructure; D013577:Syndrome
chemical_list: D005050:Etretinate
vernacular_title: Ichtyose linéaire circonflexe de Comèl: traitement par Ro 10-9359. Etude en microscopie électronique.