title: [Effect of limited motor activity on the alanine level of human blood plasma].
abstract: The plasma alanine concentration was measured in 28 healthy male test subjects exposed to head-down tilt of various duration (2-hour exposure at-12 degrees, 7-day exposure at-6 degrees, 49-day exposure at-4 degrees, and 120-day exposure at-4 degrees). Head-down tilt led to alanine changes that correlated with exposure time. These results suggest that alanine concentrations in blood reflect to a certain extent the rate of hepatic gluconeogenesis and depend significantly on the hypokinetic time. The findings can be clinically used as a measure of hepatic gluconeogenesis in bed-ridden patients that may require preventive or therapeutic treatment.
mesh_terms: D000328:Adult; D000409:Alanine / Q000097:blood*; D001510:Bed Rest; D005943:Gluconeogenesis; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011187:Posture; D013997:Time Factors
chemical_list: D000409:Alanine
vernacular_title: Vliianie ogranicheniia dvigatel'noĭ aktivnosti na uroven' alanina v plazme krovi cheloveka.