Carbohydrate metabolism in the genital organs of adult female rhesus monkeys: effect of prolonged treatment with centchroman, an antiimplantation agent.
Weekly oral administration of centchroman at 1 and 2.5 mg/kg doses for 3, 6 or 12 months to adult female rhesus monkeys (Macaca mulatta) significantly decreased glycogen content and activity of phosphorylase, glucokinase, lactate dehydrogenase and glucose 6-phosphate dehydrogenase enzymes in all the genital tract tissues. In general, the inhibition was dose and time dependent. No effect was, however, observed in the liver and serum.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D002486:Centchroman / Q000494:pharmacology*; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects / Q000378:metabolism*; D005941:Glucokinase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008253:Macaca mulatta; D006005:Phosphorylases / Q000378:metabolism
D001578:Benzopyrans; D007773:Lactates; D002486:Centchroman; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006005:Phosphorylases; D005941:Glucokinase