Pulmonary elimination of 5-fluorouracil in anesthetized rats.
The pharmacokinetics of 5-fluorouracil (5-FU) was investigated in tumor-free anesthetized rats. Blood samples in the carotid artery and in the right atrium were sampled by cannulation during the steady-state infusion of 5-FU. Serum and blood samples were assayed by HPLC. After comparing the steady-state concentration of 5-FU in the right carotid artery with that in the right atrium, it was concluded that there was no pulmonary elimination of 5-FU in the anesthetized rat.
D000758:Anesthesia; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005472:Fluorouracil / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008168:Lung / Q000378:metabolism*; D051381:Rats
D005472:Fluorouracil