title: Synthesis of 3-phenyl-3-phenylthiopropionic acids, amides, amines and studies on their pharmacological properties.
abstract: The addition of mercaptobenzene to cinnamic acids yielded 3-phenyl-3-phenylthiopropionic acids which were then converted to the amides. The latter compounds were reduced to the amines with lithium aluminum hydride. Some of the obtained amides displayed significant biological activity.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001522:Behavior, Animal / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000633:toxicity; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000008:administration & dosage
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010666:Phenylpropionates; D014363:Tryptamines; C030820:tryptamine; C035253:3-phenylpropionic acid; D012110:Reserpine; D001058:Apomorphine; D010433:Pentylenetetrazole