[Effect of complamine and nicospan on the cerebral blood flow and its regulation in changes in blood pressure].
Acute experiments on anesthetized cats under the conditions of artificial respiration were made to study the action of intravenous injection of complamine (75 mg/kg) and nicospan (0.5 ml/kg) on the cerebral blood flow (CBF), arterial blood pressure in venous vessels of the head (VP) and autoregulatory reactions (AR) of cerebral vessels at different levels of arterial blood pressure. The results of experiments indicate that both drugs provoke phasic (dilatation-constriction) responses of cerebral vessels, reduction of the CBF and a decrease in BP and VP. Unlike complamine, nicospan often caused at first a short-term increase in the CBF and VP followed by their lowering as compared with the initial values. Both the drugs brought about alterations in AR of cerebral vessels toward lower levels of BP.
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D005260:Female; D006706:Homeostasis; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009525:Niacin / Q000627:therapeutic use*; D013806:Theophylline / Q000031:analogs & derivatives*; D014655:Vascular Resistance / Q000187:drug effects; D014971:Xanthinol Niacinate / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D009525:Niacin; D014971:Xanthinol Niacinate; D013806:Theophylline
Vliianie komplamina i nikoshpana na mozgovoĭ krovotok i ego reguliatsiiu pri izmeneniiakh arterial'nogo davleniia.