[Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans].
Elimination of caffeine from plasma and excretion of main metabolites of metamizol (noramidopyrine methanesulphonate sodium) in urine were determined in young healthy (age 18-27 years) and in old aged volunteers (older than 65 years). From the elimination velocity of these model substances conclusions concerning the activity of 3-methylcholanthrene inducible (caffeine elimination) and of phenobarbital inducible (metamizol elimination) isoenzymes of cytochrome P-450 are drawn. Whereas in old age caffeine metabolism is unchanged, there is a strong delay in renal excretion of main metabolites of metamizol in old volunteers. It is concluded that different hepatic cytochrome P-450 isoenzymes are differentially influenced with increasing age in men.
D000368:Aged; D000375:Aging; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004177:Dipyrone / Q000378:metabolism* / Q000652:urine; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D007700:Kinetics; D008297:Male
D007527:Isoenzymes; D000632:Aminopyrine; D002110:Caffeine; D004177:Dipyrone; D003577:Cytochrome P-450 Enzyme System; D003404:Creatinine
Die Elimination von Coffein und Metamizol zur in-vivo-Charakterisierung Cytochrom P-450-abhängiger Biotransformationsreaktionen beim alten Menschen.