Effect of long-term centchroman treatment on some estrogen-sensitive biochemical constituents in the genital organs of female rhesus monkeys (Macaca mulatta).
Effect of long-term Centchroman (3,4,-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)-phe nyl)-7-methoxy chroman) treatment on some estrogen-sensitive biochemical parameters in the genital organs of female rhesus monkey was studied. Centchroman treatment did not demonstrate any consistent pattern of stimulation or inhibition in any of the estrogen-sensitive biochemical parameters. However, glycogen recorded a gradual decline in uterus, cervix and vagina. The results thus indicate that Centchroman evoked a mixed response probably due to manifestations of both estrogenic and antiestrogenic properties.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002486:Centchroman / Q000494:pharmacology*; D004965:Estrogen Antagonists; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects* / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008253:Macaca mulatta; D019158:N-Acetylneuraminic Acid; D011506:Proteins / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism; D013997:Time Factors
D001578:Benzopyrans; D004965:Estrogen Antagonists; D004967:Estrogens; D007773:Lactates; D011506:Proteins; D012794:Sialic Acids; D002486:Centchroman; D019344:Lactic Acid; D006003:Glycogen; D000469:Alkaline Phosphatase; D019158:N-Acetylneuraminic Acid