Antagonism of the muscarinic effects of edrophonium with atropine or glycopyrrolate. A comparative study.
The efficacy of atropine or glycopyrrolate in doses of 10 or 20 micrograms kg-1 and 5 or 10 micrograms kg-1, respectively, has been compared when administered to block the muscarinic effects of edrophonium 0.5 mg kg-1 administered for the reversal of neuromuscular blockade. Both doses of atropine and the higher dose of glycopyrrolate prevented any edrophonium-induced decreases in heart rate; glycopyrrolate at this dose was associated with tachycardia. Atropine and edrophonium could be safely administered together in a mixture. The control of oropharyngeal secretions was adequate even with the lower doses of both anticholinergic agents. Atropine 10 micrograms kg-1 appears to be a better anticholinergic agent for use with edrophonium.
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D004491:Edrophonium / Q000037:antagonists & inhibitors*; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D013997:Time Factors
D011759:Pyrrolidines; D004491:Edrophonium; D001285:Atropine; D006024:Glycopyrrolate