Clindamycin for treatment of Toxoplasma polymyositis in a dog.
Toxoplasma polymyositis was diagnosed in a dog given repeated injections of glucocorticoids for a skin condition. The dog developed generalized lower motor neuron paralysis, with generalized hyperesthesia, myoglobinuria, and high serum muscle enzyme activities. Diagnosis of toxoplasmosis was confirmed by muscle biopsy and seroconversion. Despite supportive care, the dog's neurologic status deteriorated progressively until parenteral treatment with clindamycin was instituted. The dog made a gradual recovery, with complete return of locomotor function and muscle mass within 2 months.
D000818:Animals; D002981:Clindamycin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008297:Male; D009220:Myositis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014124:Toxoplasmosis, Animal / Q000188:drug therapy* / Q000473:pathology
D005938:Glucocorticoids; D002981:Clindamycin