Effects of cholecystokinin and vasoactive intestinal peptide on locomotion and rearing in neofrontal decorticated rats.
Cholecystokinin octapeptide (CCK-8) and vasoactive intestinal peptide (VIP) have been shown to be antagonistic in various parameters in the rat in our previous studies. In the present investigation the effects of CCK-8 and VIP on spontaneous motility and rearing activity were observed in sham-operated and neofrontal decorticated rats. The results indicate that VIP antagonizes the effects of CCK-8 on spontaneous motility and rearing, and the effects are more apparent in the decorticated rats. It was suggested that CCK-8 affects presynaptic dopaminergic systems, while VIP is likely to stimulate post-synaptic dopaminergic mechanisms.
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D002541:Cerebral Decortication; D007106:Immune Sera; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012844:Sincalide / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D007106:Immune Sera; D014660:Vasoactive Intestinal Peptide; D012844:Sincalide