[Role of the autoregulatory component in the vascular reaction of the brain to euphylline].
The method of hydrogen clearance used for the registration of cerebral blood flow in acute experiments on anesthetized white rats with artificial respiration has shown that aminophylline had a biphasic effect (dilatation-constriction) on cerebral vessels, particularly with stable blood pressure. Systemic hypotension provoked an increase in dilatation response. With blood pressure reduced, autoregulation levels lowered.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002536:Cerebral Arteries / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects
D000628:Aminophylline; D010100:Oxygen
Rol' autoreguliatornogo komponenta v reaktsii sosudov mozga na éufillin.