Concentrations of metronidazole and tinidazole in male genital tissues.
The steady-state concentrations of metronidazole and tinidazole in male genital tissues were analyzed in patients subjected to elective gonadal surgery. The nitroimidazoles were administered orally at 500 mg every 8 h, beginning 5 days before the operation. Eight hours after the last dose, the concentrations of tinidazole were 24.1 +/- 2.5 micrograms (mean +/- standard error of the mean)/g of prostatic tissue, 29.1 +/- 2.9 micrograms/g of vas deferens, 22.1 +/- 2.1 micrograms/g of epididymis, and 18.6 +/- 2.3 micrograms/g of testis. The corresponding values of metronidazole were 14.3 +/- 1.8 micrograms/g, 15.9 +/- 1.2 micrograms/g, 14.0 +/- 1.2 micrograms/g, and 12.5 +/- 1.7 micrograms/g, respectively.
D000368:Aged; D004822:Epididymis / Q000378:metabolism; D005837:Genitalia, Male / Q000378:metabolism*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D009593:Nitroimidazoles / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D014011:Tinidazole / Q000097:blood / Q000378:metabolism*; D014649:Vas Deferens / Q000378:metabolism
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole