title: Levels of acetyl hydrazines and rate of acetylation of isoniazid in adult tuberculosis patients.
abstract: Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all show an increase in circulating levels of NH3 at 6 hrs. Mono and diacetyl hydrazine levels in blood and urine were detectable in all the patients up+o 24 hrs though the maximum levels were observed at different intervals after the intake of INH.
mesh_terms: D000107:Acetylation; D000328:Adult; D000641:Ammonia / Q000097:blood; D006801:Humans; D006834:Hydrazines / Q000097:blood*; D007538:Isoniazid / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D006834:Hydrazines; D000641:Ammonia; C014949:acetylhydrazine; D007538:Isoniazid; C042228:N,N'-diacetylhydrazine