Myopathy with tubular aggregates in a patient adrenalectomized for Cushing's syndrome.
We report a patient with attacks of muscle weakness and mild myopathy with tubular aggregates, following bilateral adrenalectomy for adrenal Cushing's syndrome and replacement therapy with cortisone acetate and 9 alpha-fluorohydrocortisone. The replacement of 9 alpha-fluorohydrocortisone therapy by desoxycorticosterone acetate therapy led to the cessation of the attacks.
D000315:Adrenalectomy / Q000009:adverse effects*; D000328:Adult; D001706:Biopsy; D003348:Cortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000150:complications / Q000601:surgery*; D003900:Desoxycorticosterone / Q000627:therapeutic use; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology / Q000648:ultrastructure; D009135:Muscular Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011183:Postoperative Complications
D003900:Desoxycorticosterone; D005438:Fludrocortisone; D003348:Cortisone