[Tridentate N-N-N chelating systems as potential antitumor agents].
Tridentate chelating agents, as potential antitumor agents, were prepared by condensing 2-quinolylhydrazines, 2-pyridylhydrazine and 2-benzothiazolylhydrazine with pyridine-2-aldehyde, 6-methylpyridine-2-aldehyde, 2-acetylpyridine and 2-benzoylpyridine. All compounds were tested against Lymphocytic leukemia P388. The active pyridine-2-aldehyde-4-methyl-2-quinolylhydrazone [1-(4'-methyl-2'-quinolyl)-3-(2'-pyridyl)-1,2-diaza-2-propene] (I d) was also tested against other experimental tumors and proved inactive.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D002460:Cell Line; D002614:Chelating Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006835:Hydrazones / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; D002614:Chelating Agents; D006835:Hydrazones
Sistemi chelanti tridentati N-N-N quali potenziali agenti antitumorali.