Coagulation of plasma from the chicken (Gallus domesticus): phospholipids influence clotting rates induced by components from Russell's viper venom.
Added phospholipid failed to accelerate chicken-plasma coagulation, induced by high concentrations of crude Russell's viper venom; however, similarly induced coagulation of canine and human plasma proceeded more rapidly when phospholipid was added. Phospholipid reduced clotting times of canine, human and also chicken plasma when partially purified factor X-activating enzyme from Russell's viper venom was the inducing agent. In the absence of added phospholipid, preincubation of chicken plasma with factor V-activating enzyme from Russell's viper venom accelerated factor X-activating-enzyme-induced coagulation. Preincubation of chicken plasma with the factor V-activating enzyme slowed factor X-activating-enzyme-induced coagulation in the presence of added phospholipid.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D002645:Chickens; D002850:Chromatography, Gel; D004285:Dogs; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007700:Kinetics; D010743:Phospholipids / Q000494:pharmacology*; D013045:Species Specificity; D013997:Time Factors; D014757:Viper Venoms / Q000302:isolation & purification / Q000494:pharmacology*
D010743:Phospholipids; D014757:Viper Venoms