Minor graft-versus-host reaction: very early effects on hepatic and exocrine pancreatic functions in mice.
The alterations of aspartate aminotransferase (GOT), lipase, alpha-amylase, glucose, urea and bilirubin plasma levels, as well as body weight and electrocardiogram tracings were monitored in individual mice, as organ dysfunction tests, throughout a graft-versus-host reaction (GVHR) induced by minor non-H-2 histocompatibility antigens. Starting in the first two weeks, elevations of GOT and decreases of alpha-amylase and lipase were found indicating deterioration of liver and exocrine pancreatic function.
D000818:Animals; D006086:Graft vs Host Disease / Q000097:blood / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology; D006824:Hybridization, Genetic; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D010179:Pancreas / Q000503:physiopathology