title: Effect of urokinase on posterior penetrating eye injuries.
abstract: We studied the effect of urokinase on the natural course of posterior penetrating eye injury in an animal model that consistently results in late tractional retinal detachment. A standard penetrating injury was performed on both eyes of 20 rabbits. Each eye received 0.4 mL of heterologous rabbit plasma. Then 10 000 U of urokinase was injected in one randomly chosen eye of each animal; an equal volume of balanced salt solution (BSS) was injected in the other. By 5 to 6 weeks after the surgery 13 (65%) of the 20 urokinase-injected eyes and 15 (75%) of the 20 BSS-injected eyes showed retinal detachment; the proportions are not significantly different. Gross and microscopic study of the enucleated, sectioned eyes failed to reveal any features distinguishing the control and urokinase-treated eyes. Thus, urokinase did not appreciably alter the natural course of development of late tractional retinal detachment after posterior penetrating eye injury.
mesh_terms: D000818:Animals; D005131:Eye Injuries / Q000150:complications / Q000188:drug therapy*; D005260:Female; D008297:Male; D011817:Rabbits; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control*; D012965:Sodium Chloride / Q000627:therapeutic use; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*; D014950:Wounds, Penetrating / Q000150:complications / Q000188:drug therapy*
chemical_list: D012965:Sodium Chloride; D014568:Urokinase-Type Plasminogen Activator