The lack of antifungal activity by avermectin B1a.
Streptomyces avermitilis produces avermectin, oligomycin and a polyene antifungal. The latter two compounds account for the antifungal activity in the methanol extracts of the fermentation broth. Pure avermectin does not inhibit fungi or affect fungal chitin metabolism.
D000935:Antifungal Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000378:metabolism; D002686:Chitin / Q000378:metabolism; D007559:Ivermectin / Q000031:analogs & derivatives*; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009089:Mucor / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology
D000935:Antifungal Agents; D007783:Lactones; D009840:Oligomycins; D002686:Chitin; C022120:avermectin B(1)a; D007559:Ivermectin; C019264:avermectin