Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats.
The time course for the development of morphine tolerance, following prolonged sweet intake, was examined in randomly bred Sabra rats. Exposure to 3% glucose in 6 mM saccharin solution increased drinking by about three times as compared to rats supplied only with water. Suppression of the analgesic effect of morphine was already detectable after 24 h of intake and became progressively more marked within the next 5 weeks. These results support an active interaction between sweet consumption and endogenous opioids in randomly bred rats.
D000818:Animals; D001921:Brain / Q000502:physiology; D004361:Drug Tolerance; D004723:Endorphins / Q000502:physiology; D005260:Female; D005518:Food Preferences; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology*; D012653:Self Stimulation / Q000502:physiology; D013649:Taste / Q000502:physiology*
D004723:Endorphins; D009020:Morphine; D012439:Saccharin