Chronic administration of D-amphetamine increases [3H]spiroperidol binding in cat brain.
Administration of D-amphetamine sulfate twice daily for 10 consecutive days, in doses increasing from 10 mg/kg per day (i.p.) to 30 mg/kg per day resulted in significant increases in the Bmax for [3H]spiroperidol receptor binding in the striatum (+44.7%) and limbic forebrain (+40.3%) in cats. There were no significant changes in the KD value for either brain region. A single dose of amphetamine (15 mg/kg i.p.) produced no significant changes in [3H]spiroperidol binding in either brain region. These data are in contrast with previous studies which reported a significant decrease in dopamine receptor binding following chronic amphetamine treatment in rats.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002090:Butyrophenones / Q000378:metabolism*; D002415:Cats; D003342:Corpus Striatum / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology*; D005260:Female; D008032:Limbic System / Q000378:metabolism; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism*; D013997:Time Factors
D002090:Butyrophenones; D011954:Receptors, Dopamine; C031611:spiroperidol receptor; D013134:Spiperone; D003913:Dextroamphetamine