title: Autoradiographic assessment of [3H]proline uptake by neurons of epileptogenic mirror focus.
abstract: Epileptogenic mirror focus was produced in the left parietal area of the rat brain by cobalt implantation into the contralateral hemisphere. On the 14th day after cobalt implantation [3H]proline was injected into both experimental and control rats (without cobalt). The incorporation of [3H]proline in neurons of layers III and V of the parietal brain cortex and neurons of the nucleus lateralis thalami was investigated by the autoradiography technique. A statistically reliable increase in [3H]proline uptake was observed in neurons of layer III (31%) and in neurons of layer V (41%) of the epileptogenic mirror focus. The other neuronal types revealed no reliable changes. The morphological and functional aspects of the altered protein metabolism during epileptogenesis are discussed.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001692:Biological Transport; D001921:Brain / Q000378:metabolism*; D003035:Cobalt; D004343:Drug Implants; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005780:Gelatin; D008297:Male; D009474:Neurons / Q000378:metabolism*; D011392:Proline / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
chemical_list: D004343:Drug Implants; D014316:Tritium; D003035:Cobalt; D005780:Gelatin; D011392:Proline