Reaction products of dimethyl sulfoxide with 5,5-disubstituted barbituric acids and their biological properties.
In the reaction of 5,5-disubstituted barbituric acids 1-5 with DMSO mixtures of compounds with one (6, 8, 10, 12) or two methylthiomethyl groups (7, 9, 11, 13) at one or both nitrogen atom are formed. Some of obtained compounds were screened for their central action namely anticonvulsant activity.
D000818:Animals; D001463:Barbiturates; D001522:Behavior, Animal / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004121:Dimethyl Sulfoxide; D004597:Electroshock; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000503:physiopathology; D013239:Stereotyped Behavior / Q000187:drug effects; D013329:Structure-Activity Relationship
D001463:Barbiturates; D004121:Dimethyl Sulfoxide