Induction of meiotic chromosomal aberrations by sulphaguanidine.
Cytological investigations on the effects of sulphaguanidine on meiotic cells have been carried out. Concentrations of 4.165, 6.25 and 8.33 mg of the drug were orally administered to Swiss albino male mice as single and cumulative doses. In the latter the drug was fed consecutively for 5 days at 24 h intervals. Meiotic chromosomal preparations were made after 24 h and at weekly intervals up to the fifth week following drug administration. Structural aberrations like gaps, breaks, fragments and multivalent associations (translocations) were scored for assessing clastogenic activity. Mitoclasic effects were analysed by scoring the polyploids. A high rate of both autosomal and sex chromosomal univalents were recorded in the series treated. A non-clastogenic and a very weak mitoclasic property of the drug is suggestive and is comparable to observations on the effects of sulphadiazine previously reported.
D000284:Administration, Oral; D000818:Animals; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D004334:Drug Administration Schedule; D006146:Guanidines / Q000633:toxicity*; D008297:Male; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D012729:Sex Chromosome Aberrations / Q000139:chemically induced; D013414:Sulfaguanidine / Q000008:administration & dosage / Q000633:toxicity*
D006146:Guanidines; D013414:Sulfaguanidine