Effects of verapamil on the smooth muscle of the horse urinary tract.
The effects of verapamil, a calcium antagonist agent, were studied on smooth muscle preparations of the lower urinary tract of horses. Verapamil (2 X 10(-4) to 2 X 10(-8) M) relaxed the ureter, urethra and urinary bladder preparations contracted by potassium (127 mM), L-noradrenaline (2 X 10(-5) M), histamine (2 X 10(-5) M) and acetylcholine (2 X 10(-5) M). These results allow the conclusion that verapamil has a dose-dependent relaxing effect on smooth muscle of the lower urinary tract.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D006632:Histamine / Q000494:pharmacology; D006736:Horses / Q000502:physiology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014513:Ureter / Q000187:drug effects; D014521:Urethra / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D006632:Histamine; D014700:Verapamil; D000109:Acetylcholine; D011188:Potassium; D009638:Norepinephrine