[Effect of phenobarbital and benzonal on succinate and alpha-ketoglutarate oxidation by rat brain mitochondria].
Phenobarbital and Benzonal in anticonvulsive doses depress energy production by brain mitochondria of rats, with phenobarbital inhibiting NAD-dependent respiration and Benzonal oxidation of succinate.
D020155:3-Hydroxybutyric Acid; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D006885:Hydroxybutyrates / Q000378:metabolism; D066298:In Vitro Techniques; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013386:Succinates / Q000378:metabolism*; D019802:Succinic Acid
D000927:Anticonvulsants; D001463:Barbiturates; D006885:Hydroxybutyrates; D007656:Ketoglutaric Acids; D013386:Succinates; D009243:NAD; D019802:Succinic Acid; D013385:Succinate Dehydrogenase; D020155:3-Hydroxybutyric Acid; C002915:benzobarbital; D010634:Phenobarbital
Vliianie fenobarbitala i benzonala na okislenie suktsinata i al'fa-ketoglutarata mitokhondriiami mozga krys.