Antihepatotoxic actions of tannins.
The antihepatotoxic effects of tannin analogues were examined utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most tannins showed significant antihepatotoxic effects in these two assay systems. Hydrolyzable tannins generally exhibited an intense enzyme inhibitory action on glutamic-pyruvic transaminase while condensed tannins exerted a much less inhibitory action, although variations were observed depending on structure. Structure-activity relationships are discussed.
D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D005688:Galactosamine / Q000633:toxicity; D051381:Rats; D013634:Tannins / Q000627:therapeutic use*
D013634:Tannins; D005688:Galactosamine; D000410:Alanine Transaminase