Anticonvulsant and convulsant properties of flurazepam.
The anticonvulsant efficacy of the benzodiazepine flurazepam was tested in rats treated with a convulsant dose of either picrotoxin or 3-mercaptopropionic acid. Against picrotoxin, a significant anticonvulsant effect was observed in the range of 30-60 mg/kg, i.p. Epileptogenicity increased as doses of flurazepam were increased from 60 to 200 mg/kg, and at a dose of 400 mg/kg all subjects died. In similar tests, the benzodiazepines clonazepam and triazolam produced only dose-dependent increases in anticonvulsant efficacy. Flurazepam also proved to be an effective anticonvulsant in tests against 3-mercaptopropionic acid. The results of this study provide further evidence that benzodiazepines have varying degrees of epileptogenicity.
D015097:3-Mercaptopropionic Acid / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D005479:Flurazepam / Q000494:pharmacology*; D008297:Male; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D014229:Triazolam / Q000494:pharmacology
D015097:3-Mercaptopropionic Acid; D000927:Anticonvulsants; D003292:Convulsants; D005479:Flurazepam; D010852:Picrotoxin; D014229:Triazolam