[New psychotropic agents. 2. Synthesis and pharmacologic activity of derivatives of 5H-pyrrolo[1,2-b][1,2,5]benzotriazepines].
Bischler-Napieralski intramolecular cyclization of N-(2-aroylaminophenyl)-N-methyl-1H-pyrrol-1-amines and reaction of arylaldehydes on N-(2-aminophenyl)-N-methyl-1H-pyrrol-1-amine furnished 11-aryl-5-methyl-5H-pyrrolo[1,2-b][1,2,5]benzotriazepines and 11-aryl-10,11-dihydro-5-methyl-5H-pyrrolo[1,2-b][1,2,5]benzotriazepin es respectively. The latter reaction required in some cases the use of p-toluenesulphonic acid as a catalyst. The new tricyclic derivatives described were tested for pharmacological evaluation of their psychotropic activity.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001552:Benzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D001552:Benzazepines; D011619:Psychotropic Drugs; D011758:Pyrroles
Ricerche su nuovi agenti psicotropi. Nota II. Sintesi ed attività farmacologica di derivati della 5H-pirrolo[1,2-b][1,2,5]benzotriazepina.