Split virus influenza vaccination in children: an evaluation of efficacy.
Twenty-seven children aged between 4 and 13 years were given two injections of a split virus influenza vaccine (MFV-Ject, Institut Merieux) at a dose of 0.5 ml and an interval of 1 month. Each vaccination contained A/Philippines/2/82 (H3 N2) 10 micrograms HA, A/Brazil/11/78 (H1 N1) 10 micrograms HA, B/Singapore/222/79 15 micrograms HA. The overall serological response was good although the B group virus produced slightly less response; however, no children were seropositive to B prior to vaccination, reflecting a low previous exposure. Children aged over 10 years showed a generally higher serological response. Side-effects were minimal. A favourable reactogenicity/efficacy ratio was found.
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines