[Spray film coating of spherical microgranules with non-aqueous varnish film-formers].
To coat crystals and spherical microgranules with polymer films, the influence of different components of the spray on the release behaviour of the coating product has been tested by means of a spray coating process. The examinations which had been based on cellulose acetatephthalate and various polyacrylate types, were aimed at technological lab parameters of the process as well as at the choice of the solvents, the polymer type and the plasticiser admixture. The liberation test has been made in artificial digestives. The results show that the knowledge of the effects of varied dispensing components will enable as well an optimization of the technological process as a purposeful control of the required retarded effects of the final product.
D004339:Drug Compounding; D007700:Kinetics; D011108:Polymers; D011208:Powders; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013696:Temperature
D011108:Polymers; D011208:Powders; D013608:Tablets, Enteric-Coated
Sprühfilmcoating von sphärischen Mikroformlingen mit nichtwässrigen Lackrezepturen.