title: The use of two alpha blocking agents, phenoxybenzamine and phentolamine, in ointment and injection form to improve skin flap survival in rats.
abstract: Two alpha blocking agents, phenoxybenzamine and phentolamine, were tested to see if their use improved skin flap survival in rats. The agents were used in two ways: in local injections and topical applications. The results showed an increased duration of flap viability with both modalities, but the topical application was the most effective.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D007279:Injections, Subcutaneous; D009824:Ointments; D010643:Phenoxybenzamine / Q000008:administration & dosage / Q000627:therapeutic use*; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013524:Surgical Flaps
chemical_list: D009824:Ointments; D010643:Phenoxybenzamine; D010646:Phentolamine