title: Vasodilator effect of indapamide in dog mesenteric vasculature.
abstract: Effects of indapamide, trichlormethiazide and hydralazine on isolated, perfused dog mesenteric vasculature and helical strips of the dog mesenteric artery were compared. It appears that indapamide-induced hypotension is associated with a direct relaxant action on arterial and arteriolar smooth muscle, whereas hydralazine acts exclusively on resistance vessels.
mesh_terms: D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D004285:Dogs; D006830:Hydralazine / Q000494:pharmacology; D066298:In Vitro Techniques; D007190:Indapamide / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D013152:Splanchnic Circulation / Q000187:drug effects*; D014237:Trichlormethiazide / Q000494:pharmacology; D014665:Vasodilator Agents
chemical_list: D004232:Diuretics; D014665:Vasodilator Agents; D006830:Hydralazine; D007190:Indapamide; D014237:Trichlormethiazide