title: Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants.
abstract: Eleven mother-infant pairs were studied to determine the effect of maternal caffeine ingestion (500 mg/day) on heart rate and sleep time of the infants. In a balanced cross-over design, mothers ingested 5 cups of decaffeinated coffee daily during one 5-day period and 5 cups of decaffeinated coffee with added caffeine (100 mg/cup) during another 5-day period. Concentrations of caffeine in milk on the last day of the caffeine period ranged from 1.6 to 6.2 micrograms/ml and the intake of caffeine by the infants was estimated to be 0.3-1.0 mg/kg/day. Infant serum did not contain detectable amounts of caffeine on the last day of either experimental period. Performance during the caffeine and no-caffeine periods was not significantly different with respect to either 24-hour heart rate or sleep time.
mesh_terms: D000375:Aging; D001942:Breast Feeding; D002110:Caffeine / Q000032:analysis / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000032:analysis; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
chemical_list: D002110:Caffeine