title: Acute effects of lithium on hippocampal kindled seizures.
abstract: The effects of lithium chloride on seizure activity generated by stimulation of hippocampal kindled rats were studied. Acute administration of 0, 0.25, 0.50, 1.5, 3.0, and 5.0 mEq/kg i.p. resulted in serum levels ranging from clinically subtherapeutic to toxic during the subsequent 4 h. Afterdischarge threshold and seizure severity were unchanged by these levels of lithium. Afterdischarge duration was somewhat prolonged, reaching a significant level only for the 3.0-mEq/kg dose. It is concluded that lithium shows a minor proconvulsant effect after acute administration in the kindled hippocampal seizure model.
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000187:drug effects; D007696:Kindling, Neurologic; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D012377:Rodentia; D012640:Seizures / Q000188:drug therapy*
chemical_list: D008094:Lithium