Purine acyclic nucleosides. 6-Dimethylamino-9-[(2-phenylalanylamido-1-substituted- ethoxy)methyl]purines as candidate antivirals.
Several acyclic puromycin analogues containing hydrocarbon substituents on the 1'-position of the aminoethoxymethyl moiety were synthesized and tested for antiviral activity. The N-carbobenzoxy intermediate 7c was active in vitro against Mengo and Semliki Forest viruses.
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology; D011691:Puromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D011687:Purines; D011691:Puromycin