Study of two controlled-release theophylline preparations.
Two sustained-release theophylline preparations, one a 12-hour and the other a 24-hour product, were compared in 20 subjects with stable asthma. All patients had good control of symptoms, and the calculated pharmacokinetic parameters were comparable for both drugs. The 24-hour sustained-release preparation can thus be utilized in the therapy of asthma.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood
D003692:Delayed-Action Preparations; D013806:Theophylline