A possible role of endogenous adenosine in the sedative action of meprobamate.
The behavioral interaction of intraperitoneal (i.p.) injections of meprobamate with intracerebroventricular (i.c.v.) injections of adenosine or 5'-N-ethylcarboxamidoadenosine (NECA) was examined on spontaneous locomotor activity in mice. The locomotor depressant effect of meprobamate, an adenosine uptake inhibitor, was potentiated by adenosine, but not by NECA, an uptake-resistant adenosine analogue. These findings suggest that heightened endogenous adenosine levels could mediate some of the central actions of meprobamate.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D006993:Hypnotics and Sedatives; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D008620:Meprobamate / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
D006993:Hypnotics and Sedatives; D019830:Adenosine-5'-(N-ethylcarboxamide); D008620:Meprobamate; D000241:Adenosine