[Experimental morphological study of the effect of liposomes in CCl4 poisoning].
The experiments on white mice have shown CCl4 to induce 24 hours after its injection focal changes in the liver, such as hepatocyte necrotization accompanied by lell organoid destruction, drastic reduction in glycogen content and increased fat content, as well as considerable decline in the activity of aerobic and anaerobic metabolic enzymes. Liposome administration attenuated the lytic effect of poison, promoting the integrity of subcellular hepatocyte structures. Distrophic changes in the latter led to increased glycogen content lower lipid level and intensified bioenergic processes.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D004353:Drug Evaluation, Preclinical; D006651:Histocytochemistry; D008081:Liposomes / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron
D000931:Antidotes; D008081:Liposomes
Eksperimental'no-morfologicheskoe izuchenie vliianiia liposom pri intoksikatsii CCl4.