title: Evidence for a role of the preoptic area in lateral hypothalamic self-stimulation.
abstract: We examined the effects of unilateral radiofrequency lesions in the preoptic area on lateral hypothalamic self-stimulation in 15 rats. The animals were tested for self-stimulation in the lateral hypothalamus at 3 different current intensities from electrodes placed in both hemispheres, and then received a unilateral lesion in the preoptic area. Four hours later they were again tested for self-stimulation at the 3 current intensities and then daily over the following 14 days, or until they recovered their presurgical rates of self-stimulation. Rate of self-stimulation decreased in the damaged hemisphere, and recovered to prelesion levels within 2 weeks in 6 of 9 rats. In the intact hemisphere rate of self-stimulation increased above the prelesion level during a period from 1 to 2 weeks after the lesion. These results suggest that the preoptic area is involved in lateral hypothalamic self-stimulation. The effects of D-amphetamine (1 mg/kg) and apomorphine (2 mg/kg) injections on turning behavior were also studied in an open field and in a rotometer. Apomorphine induced contraversive turning to the lesion side in the open field and D-amphetamine induced ipsiversive turning in the rotometer.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001931:Brain Mapping; D003913:Dextroamphetamine / Q000494:pharmacology; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012653:Self Stimulation / Q000502:physiology*
chemical_list: D001058:Apomorphine; D003913:Dextroamphetamine