A convenient method for the oxidation of nucleoside phosphites to phosphates.
Bis(trimethyl) peroxide serves as an excellent agent for oxidation of nucleoside phosphites to the phosphates. The reaction is conspicuously accelerated by added trimethylsilyl triflate or Nafion-TMS.
D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010757:Phosphorous Acids; D012265:Ribonucleotides / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D010757:Phosphorous Acids; D012265:Ribonucleotides