Tardive dyskinesia controlled by anticholinergic agents.
Tardive dyskinesia appeared in a 17-year-old boy following withdrawal of pimozide (Orap) and thioridazine (Melleril). The choreodyskinetic movements, which were limited to the limbs and the trunk, cleared with anticholinergic drugs but were dramatically worsened by dopaminergic receptor blockers. Therefore, therapy with an initial high dose of benztropine mesylate (Cogentin) associated with bromazepam (Lexotan) was instituted and was well tolerated.
D000293:Adolescent; D001590:Benztropine / Q000627:therapeutic use; D001960:Bromazepam / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008030:Lightning; D008297:Male; D010276:Parasympatholytics / Q000627:therapeutic use*; D010868:Pimozide / Q000009:adverse effects; D013881:Thioridazine / Q000627:therapeutic use
D010276:Parasympatholytics; D010868:Pimozide; D001590:Benztropine; D013881:Thioridazine; D001960:Bromazepam