[The immediate and late results of protecting the patient's normal tissues by using the gas hypoxic mixture GHM-10 in the radiation therapy of breast cancer].
The effect of inhalation of gaseous hypoxic mixture GHM-10 (oxygen--10 +/- 1.0 and nitrogen--90.0 +/- 1.0%) on radiation response of normal tissues was studied in 184 breast cancer patients. The mixture was administered to 120 patients while 74 controls received a standard course of radiotherapy. Administration of the mixture improved normal tissue resistance to radiotherapy for breast cancer and was followed by lower incidence of long-term radiation injury, lower frequency and shorter duration of general vegetative reactions to radiation.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000532:radiotherapy*; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009584:Nitrogen / Q000627:therapeutic use*; D010100:Oxygen / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000453:epidemiology / Q000517:prevention & control; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D013997:Time Factors
D011837:Radiation-Protective Agents; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
Neposredstvennye i otdalennye rezul'taty zashchity normal'nykh tkaneĭ patsienta s pomoshch'iu gazovoĭ gipoksicheskoĭ smesi GGS-10 pri luchevoĭ terapii raka molochnoĭ zhelezy.