Macrophage activation with pantethine and pantetheine-4'-phosphate.
Adjuvant activities of pantethine (PaSS) and pantetheine-4'-phosphate (PSH-4'-P) were investigated in mice. By the multiple intraperitoneal administration, both PaSS and PSH-4'-P activated the functions of mouse peritoneal adherent cells and splenic natural killer cells. PSH-4'-P was also effective for the activation of natural killer cells by single injection. In in vitro, PaSS induced interleukin-1 (IL-1) secretion at a low concentration but PSH-4'-P did not. Both PaSS and PSH-4'-P could neither induce interleukin-2 (IL-2) secretion, nor could enhance IL-2 secretion by Con A.
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D005260:Female; D007700:Kinetics; D008262:Macrophage Activation / Q000187:drug effects*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D010204:Pantetheine; C005425:pantethine; C003129:4'-phosphopantetheine