The effect of a menhaden oil-containing diet on hemostatic and lipid parameters of nonhuman primates with atherosclerosis.
Three species of nonhuman primates were fed an atherogenic diet for 6 months (baseline period) and a menhaden oil (EPA)-containing diet for 8 weeks (test period) during which various hemostatic and lipid parameters were compared. The EPA-rich diet prolonged bleeding times, inhibited platelet aggregation response to ADP and collagen, and increased mean platelet lifespan. This diet elicited an increase in the polyunsaturated fatty acids C20:5 (EPA) and C22:6 (docosahexaenoic acid) at the expense of C18:2 (linoleic acid) and C20:4 (arachidonic acid) in pooled samples of platelet membranes, creating an increase in the ratio of n-3/n-6 polyunsaturated fatty acids. The serum lipid response to a menhaden oil diet comprised a nonsignificant decrease in total serum cholesterol and a significant decrease in HDL cholesterol.
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000178:diet therapy* / Q000209:etiology; D001760:Bleeding Time; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000494:pharmacology*; D004901:Erythrocebus patas; D005395:Fish Oils; D006116:Greenland; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D004930:Inuit; D008055:Lipids / Q000097:blood*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D009821:Oils / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects
D004041:Dietary Fats; D005395:Fish Oils; D008055:Lipids; D009821:Oils; C033266:Menhaden oil