title: Amitrole: strain differences in morphological response of the liver following subchronic administration to mice.
abstract: Strain differences in the induction of hepatocellular preneoplastic lesions by amitrole were examined in NOD, ICR and DS mice. Amitrole was administered to mice in drinking water at a dose of 1% for 6 months. After 3 months, hyperplastic nodules (HN) and severe fibrosis were prominent in NOD mice but not in other strains. On examination at 6 months, both number and size of HN were greatest in the NOD strain. Furthermore, a hepatocellular carcinoma was found in a NOD mouse, suggesting that this strain is more susceptible to amitrole-induced hepatocarcinogenesis than are ICR or DS mice.
mesh_terms: D000640:Amitrole / Q000633:toxicity*; D000818:Animals; D005260:Female; D006965:Hyperplasia; D007111:Immunity, Cellular / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D051379:Mice; D008815:Mice, Inbred Strains; D011230:Precancerous Conditions / Q000139:chemically induced; D013045:Species Specificity; D014230:Triazoles / Q000633:toxicity*
chemical_list: D014230:Triazoles; D000640:Amitrole