title: Comparison of the pharmacokinetic profile of metaclazepam in old and young volunteers.
abstract: A single-centre, open, Phase I-study comparison of the pharmacokinetics of a single dose of metaclazepam 10 mg, a new 1,4-benzodiazepine has been done in 10 older and 20 younger volunteers. No important age-related effect was found on the kinetics of metaclazepam or its N-desmethyl derivative, the principal metabolite in man.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines / Q000097:blood / Q000378:metabolism*; D001711:Biotransformation; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; C047395:N-desmethylmetaclazepam; C036366:metaclazepam