title: [Synthesis and biologic activity of some stable structure analogs of platelet activating factor].
abstract: Physiologically stable structure analogues of the platelet-activating factor (PAF-acether), the acetyl group of which had been substituted by short-chain alkyl rests, had been synthesized and been tested with regard to their biological activity against thrombocytes. Five differently substituted 2-alkylmalonic acid esters with methyl rest up to n-pentyl rest had been applied the basic products. The n-propyl compound exhibits the most intense biological activity, which is, however, essentially reduced against the PAF-acether. With conditions of the examination, all the other derivatives possess a more decreased activity.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D010972:Platelet Activating Factor / Q000032:analysis / Q000502:physiology*; D010974:Platelet Aggregation
chemical_list: D010972:Platelet Activating Factor
vernacular_title: Synthese und biologische Aktivität einiger stabiler Strukturanaloga des Plättchenaktivierenden Faktors.