title: [Successful treatment of male urethritis with Chlamydia trachomatis by doxycycline].
abstract: Twenty male patients with urethritis caused by C. trachomatis were subjected to the clinical study of treatment with doxycycline (DOXY) 100 mg twice daily for 14 days. C. trachomatis was identified from urethral swab, both by direct fluorescein-conjugated anti-C. trachomatis species-specific monoclonal antibody technique (CTFA) and by culture using HeLa 229, in all cases before treatment. Almost complete agreement between CTFA and culture was obtained in the urethral swabs taken before treatment and after the 7th day of treatment. Disagreement between CTFA and culture especially CTFA-positive, culture-negative cases were observed at the third day of treatment. During the treatment course there might be the period where C. trachomatis antibody can be detected, but C. trachomatis can not be isolated by culture. After the 7th day of treatment C. trachomatis could not be identified neither by CTFA, nor by culture in all 20 cases, even after 2 to 5 weeks after the completion of the treatment. No notable side effect was experienced. Above results lead to the conclusion that treatment with DOXY 100 mg twice daily for 14 days is effective against male urethritis by C. trachomatis.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology; D002692:Chlamydia trachomatis; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014526:Urethritis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D004318:Doxycycline