title: Olfactory deprivation enhances normal spine loss in the olfactory bulb of developing ferrets.
abstract: Ferrets show a sensitive phase in their postnatal development during which they can become imprinted to food odors. At the same time the number of granule cell spines in the olfactory bulb reaches a maximum, declining significantly thereafter. In ferrets, exposed continuously to saturated levels of geraniol odor in the cage environment, the normal decline in spine number (occurring between day 60 and 90) is significantly enhanced. No such effects were observed during earlier ontogenetic phases. This late postnatal phase is further associated with a marked and significant decrease in total brain weight. The significance of these events to olfactory imprinting and plasticity in the developing brain is discussed.
mesh_terms: D000080462:Acyclic Monoterpenes; D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003712:Dendrites / Q000502:physiology; D005260:Female; D005289:Ferrets; D009474:Neurons / Q000502:physiology; D009830:Olfactory Bulb / Q000254:growth & development* / Q000502:physiology; D009833:Olfactory Pathways / Q000254:growth & development / Q000502:physiology; D009929:Organ Size; D012683:Sensory Deprivation / Q000502:physiology*; D013729:Terpenes / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D013729:Terpenes; C007836:geraniol