Preparation of fluorinated antibiotics followed by 19F NMR spectroscopy. I. Fluorinated vulgamycins.
Attempts to prepare fluorinated vulgamycins have been followed by 19F NMR spectroscopy. Isolation, structural elucidation and biological activities of fluorovulgamycins are reported.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D005461:Fluorine; D009682:Magnetic Resonance Spectroscopy
D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; C047540:fluorovulgamycins; D005461:Fluorine; C012306:enterocin