title: The role of tobacco smoke, iron ore mine dusts, viruses, and chemicals in experimental cancer.
abstract: Assessment of long-term studies on the carcinogenic potential of certain environmental agents has indicated that all of the following appear to activate and/or promote the inherent tumors of the host strains of the animals used irrespective of the extent of additional immunological modulation accompanying the agents: tobacco smoke inhalation, the implantation and inhalation of the respirable fraction of iron ore mine dusts, acute neonatal reovirus 3 infection, urethane, and tobacco smoke inhalation following urethane treatment. It is proposed that these environmental agents function at the onc-gene level as promoters/activators rather than carcinogens, and that this now requires an understanding of the means by which certain environmental agents function at the onc-gene level.
mesh_terms: D000236:Adenoma / Q000209:etiology* / Q000276:immunology; D000818:Animals; D002273:Carcinogens; D004391:Dust / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D007501:Iron / Q000009:adverse effects*; D007942:Leukemia, Experimental / Q000209:etiology* / Q000276:immunology; D008175:Lung Neoplasms / Q000209:etiology* / Q000276:immunology; D008297:Male; D012089:Mammalian orthoreovirus 3 / Q000276:immunology*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008906:Mining; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000276:immunology; D010947:Plants, Toxic; D012087:Reoviridae / Q000276:immunology*; D012906:Smoke / Q000009:adverse effects; D013045:Species Specificity; D014026:Nicotiana
chemical_list: D002273:Carcinogens; D004391:Dust; D012906:Smoke; D007501:Iron