The protective effect of oxime pretreatment upon the inhalative toxicity of sarin and soman in rats.
The functional set-up of a static inhalation device is described. The closed system consists of a reservoir for the circulating test gas, an inhalator for "nose-only" exposure of 10 rats, and analyzers for the test gas and CO2. It has an overall volume of 200 liters. The following LCt50 values for rats exposed to noxious vapors were determined: DFP 3629, sarin 191, and soman 211 mg X min X m-3. Pretreatment with atropine (10 mg/kg) together with the oximes Toxogonin or HJ6 (each 13 mg/kg) 10 min before the exposure raised the LCt50 of sarin by a factor of 2.5 and 14, respectively. In case of soman poisoning, only HJ6 (50 mg/kg) together with atropine was effective, which increased the LCt50 by a factor of 7.
D000336:Aerosols; D000818:Animals; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012524:Sarin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D012999:Soman / Q000037:antagonists & inhibitors / Q000633:toxicity*; D013997:Time Factors
D000336:Aerosols; D009943:Organophosphorus Compounds; D010091:Oximes; D012999:Soman; D012524:Sarin