title: Effects of varying intensities of laser energy on articular cartilage: a preliminary study.
abstract: The effects of laser energy on articular cartilage were studied utilizing the neodymium YAG laser. Partial-thickness cartilage defects were surgically attempted in the femoral condyles of knee joints in guinea pigs. The defects were exposed to laser energy of varying intensities [group I, 25 J (5 W X 5 sec); group II, 75 J (15 W X 5 sec); group III, 125 J (25 W X 5 sec)]. A fourth group was studied, in which the defect was not lased. Animals were killed at weekly intervals from 1 to 6 weeks and the knee joints were subjected to histological analysis. At 5 weeks, the knees exposed to 25 and 75 J demonstrated a reparative process with chondral proliferation. The knees exposed to 125 J demonstrated fibrotic tissue and tissue necrosis that resulted in fibrosis. In the knees not exposed to laser energy, numerous foci of granulation tissue were present at all stages with the end point of healing being one of fibrosis with disorganized patchy cartilage islands.
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000166:cytology / Q000293:injuries* / Q000502:physiology; D002455:Cell Division; D004247:DNA / Q000096:biosynthesis; D006097:Granulation Tissue / Q000502:physiology; D006168:Guinea Pigs; D007834:Lasers / Q000009:adverse effects*; D012038:Regeneration
chemical_list: D004247:DNA