Gastrointestinal permeability in atopic and non-atopic mothers, assessed with different-sized polyethyleneglycols (PEG 400 and PEG 1000).
Gastrointestinal permeability was compared in seventy-one women, forty-six allergic and twenty-five non-allergic according to case history, by measuring the 6-hr urinary recovery after an oral load of different-sized polyethyleneglycols (PEG 400 and PEG 1000). Further classification, atopic and non-atopic, was obtained by skin-prick tests to inhalant and food allergens in sixty-four of the seventy-one mothers. No significant differences were observed between allergic and non-allergic women, neither regarding the maximum recovery nor the recovery ratio between a large and a small molecule. The results do not lend support to the hypothesis of a persistently increased gut permeability in atopic subjects, which in turn could possibly imply an increased risk of intrauterine sensitization of the foetus of an atopic mother.
D000328:Adult; D001692:Biological Transport; D001942:Breast Feeding; D002463:Cell Membrane Permeability / Q000187:drug effects; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology; D006969:Hypersensitivity, Immediate / Q000378:metabolism*; D007422:Intestines / Q000503:physiopathology*; D008431:Maternal-Fetal Exchange; D011092:Polyethylene Glycols / Q000378:metabolism*; D011247:Pregnancy
D011092:Polyethylene Glycols