Synthesis of some isonicotinoyl- and nicotinoyl-sulphonylamino acid derivatives and their antimicrobial activity.
The synthesis of isonicotinoylamino acids-2-sulphonylamino acids and nicotinoylamino acids-5-sulphonylamino acids (III-VII) and (XXIII-XXVII) and their corresponding methyl esters, hydrazides and some dipeptide methyl ester derivatives (VII-XXII) and (XXVIII-XXXVII) are described. Thirty two of various substituted nicotinoyl and isonicotinoyl sulphonylamino acid derivatives were found to possess specific antimicrobial activities towards different microorganisms.
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D008826:Microbial Sensitivity Tests; D009539:Nicotinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009539:Nicotinic Acids