Morphological evidence of vestibular pathology in long-term experimental diabetes mellitus. I. Microvascular changes.
The influence of long-term experimental diabetes on the microvasculature of the saccule and utricle was investigated using quantitative light and electron microscopic techniques. Basal lamina thickening or reduplication, typically seen in diabetic microangiopathy, were not observed. However, morphometric analysis did reveal a statistically significant increase in capillary diameters along with an increased vascularization of both the saccule and utricle. Both of these microvascular abnormalities may have been caused by the hemodynamic alterations known to occur in diabetes. These alterations include decreased deformability of red blood cells and increased blood viscosity. Either of these factors can lead to a greater stress on the capillary wall and possibly to a reduced oxygen delivery to the tissues.
D000704:Analysis of Variance; D000818:Animals; D002196:Capillaries / Q000473:pathology / Q000648:ultrastructure*; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000473:pathology; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D012444:Saccule and Utricle / Q000098:blood supply / Q000473:pathology*; D013997:Time Factors