Some characteristics of econazole-induced pleurisy in rats.
Aqueous suspension of econazole nitrate injected into the pleural cavity of rats induces sharp exudate formation and small leucocyte mobilization. The econazole pleurisy development is monophasic and its peak value occurs between 8 and 12 hr after econazole injection. The exudate volume and the leucocyte mobilization are inhibited by chlorpheniramine, cyproheptadine and steroidal and non-steroidal anti-inflammatory drugs.
D000818:Animals; D002351:Carrageenan / Q000633:toxicity; D002744:Chlorpheniramine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004464:Econazole / Q000633:toxicity*; D007093:Imidazoles / Q000633:toxicity*; D007249:Inflammation / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D007964:Leukocytosis / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D008407:Mast Cells; D010653:Phenylbutazone / Q000494:pharmacology; D010996:Pleural Effusion / Q000139:chemically induced / Q000503:physiopathology; D010998:Pleurisy / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007093:Imidazoles; D003533:Cyproheptadine; D002744:Chlorpheniramine; D004464:Econazole; D003907:Dexamethasone; D002351:Carrageenan; D010653:Phenylbutazone