title: The effect of intravenous infusion of urokinase on coronary artery thrombolysis in the dog.
abstract: The effect of intravenous administration of urokinase on the rate and time of thrombolysis was investigated in 22 dogs with an occlusive coronary artery thrombus induced by placement of a copper coil in the left anterior descending artery. One hour after angiographic confirmation of complete coronary artery occlusion, an intravenous bolus of urokinase was administered in a dose of either 1.2 X 10(6) units (Group 1, n = 7); 0.6 X 10(6) units (Group 2, n = 9) or 0.3 X 10(6) units (Group 3, n = 6). Reperfusion occurred in all 7 (100%) Group 1 dogs, in 7 of 9 (78%) group 2 dogs and in 3 of 6 (50%) group 3 dogs (p = 0.07 for Group 1 vs Group 3). There was no residual intra-arterial thrombus in any group 1 (high dose) dog but 4 of the 10 reperfused Group 2 or Group 3 (intermediate or low dose) dogs had small thrombus in the distal left anterior descending artery (3.5 +/- 4.0 mg) and all 5 non-reperfused dogs had thrombus in the coil (26.1 +/- 6.2 mg). The frequency of residual thrombus was significantly less in Group 1 compared to Group 2 and 3 (p less than 0.01). We conclude that intravenous administration of urokinase has a dose dependent efficacy for lysing intracoronary thrombus in the canine model.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007263:Infusions, Parenteral; D010477:Perfusion; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D014568:Urokinase-Type Plasminogen Activator