title: Experience with 1201 cerebrospinal fluid shunt procedures.
abstract: This report of our experience with 1,201 cerebrospinal fluid shunt procedures over a 17-year period includes two time periods: from 1965 to 1974 and from 1975 to 1982. The overall operative infection rate fell from 10.7% in the former period to 3.6% in the latter period. The overall average number of revisions fell from 1.8 to 0.77. The number of revisions for patients with infected shunts in the latter period was 4.07. Three hundred and eighty-four shunts were studied in the latter period for the effects of prophylactic antibiotics. No significant difference was found between the infection rate of 5.6% in the nonantibiotic group and the infection rate of 2.1% in the group receiving intravenous and intraventricular methicillin and gentamicin. Differences in the operative infection rates for patients with and without meningomyelocele and those operated on by different surgeons were not significant. The only mortalities were from nonoperative and noncerebrospinal fluid shunt causes.
mesh_terms: D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008712:Methicillin / Q000627:therapeutic use; D010537:Peritoneum; D012086:Reoperation; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology
chemical_list: D005839:Gentamicins; D008712:Methicillin