[Activation of nuclear polypeptide synthesis in rat liver cells after inhibition of template protein synthesis. The role of nuclear polypeptide synthesis in the changes of the chromatin structure].
The correlation between the rates of nuclear polypeptide synthesis (NPS) and matrix protein synthesis in rat liver cells was investigated. It was shown that NPS is activated under conditions of protein synthesis inhibition in the cytoplasm. Model experiments revealed that the NPS and ADP ribosylation systems compete for chromatin structure: ADP ribosylation induces condensation, while NPS--decondensation of chromatin.
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D003513:Cycloheximide / Q000494:pharmacology; D003864:Depression, Chemical; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D010452:Peptide Biosynthesis; D011487:Protein Conformation; D051381:Rats; D012270:Ribosomes / Q000378:metabolism; D013698:Templates, Genetic; D013997:Time Factors
D002843:Chromatin; D000246:Adenosine Diphosphate Ribose; D003513:Cycloheximide
Aktivatsiia iadernogo polipeptidnogo sinteza v kletkakh pecheni krys pri tormozhenii matrichnogo sinteza belkov. Vklad iadernogo polipeptidnogo sinteza v izmenenie struktury khromatina.