Neutralization of hyaluronidase and indirect hemolytic activities of Costa Rican snake venoms by a polyvalent antivenom.
The ability of a polyvalent antivenom produced in Costa Rica to neutralize hyaluronidase and indirect hemolytic activities of Costa Rican crotalid venoms was tested. Antivenom neutralized remarkably well hyaluronidase activity of all venoms tested, with ED50 doses ranging from 2 to 45 microliter antivenom/mg venom. Neutralization of indirect hemolytic activity was also achieved using the antivenom, with ED50 values ranging from 332 to 716 microliter antivenom/mg venom.
D000818:Animals; D000997:Antivenins / Q000494:pharmacology*; D003364:Costa Rica; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D066298:In Vitro Techniques; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D012910:Snake Venoms / Q000494:pharmacology*
D000997:Antivenins; D012910:Snake Venoms; D010741:Phospholipases A; D006821:Hyaluronoglucosaminidase