Endocrine regulation of sex differences in hepatic histidase activity.
Hepatic histidase activity in adult female rats is twice that in adult male rats. Hypophysectomy and thyroidectomy result in a significant increase in hepatic histidase activities in males, but not in females. This effect on histidase is reversed by the exogenous administration of tri-iodothyronine, but not by ectopic pituitary glands or purified pituitary hormones.
D000642:Ammonia-Lyases / Q000378:metabolism*; D000818:Animals; D005260:Female; D006638:Histidine Ammonia-Lyase / Q000378:metabolism*; D007016:Hypophysectomy; D008099:Liver / Q000201:enzymology*; D008297:Male; D010907:Pituitary Hormones / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012733:Sex Differentiation; D013963:Thyroid Hormones / Q000502:physiology; D013965:Thyroidectomy; D014284:Triiodothyronine / Q000494:pharmacology
D010907:Pituitary Hormones; D013963:Thyroid Hormones; D014284:Triiodothyronine; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase