Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine.
Adrenaline stimulates platelet aggregation via the alpha 2-adrenergic receptor; the resultant aggregation is blocked by aspirin. In conjunction with low concentrations of PAF-acether, adrenaline induces aggregation which is not susceptible to blockade by aspirin. Hydergine and other alpha 2-adrenergic antagonists block the specific aggregant action of adrenaline as well as the synergic effect in the presence of PAF-acether.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004357:Drug Synergism; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010972:Platelet Activating Factor; D010974:Platelet Aggregation / Q000187:drug effects*
D010972:Platelet Activating Factor; D004088:Dihydroergotoxine; D000255:Adenosine Triphosphate; D004837:Epinephrine