Effect of different diets on the ratio of plasma lipids/vitamin A and E in female Sprague-Dawley rats with MNU-induced mammary carcinomas.
An inverse relationship between vitamin A uptake and cancer as well as serum cholesterol concentration and cancer has been shown. An inverse relationship between serum cholesterol and retinol has also been reported. In a study, in which female Sprague-Dawley rats with MNU-induced mammary tumors were fed diets containing different amounts of fat and vitamins A and E, the effect of these diets on the inverse association between the cancer risk and both plasma lipids and vitamin A, E was investigated. According to the data obtained there is not only a relationship between plasma cholesterol and vitamin A, but also a similar relationship between cholesterol and vitamin E. The relationship between triglycerides and the two vitamins was also parallel to that of the cholesterol-vitamin A relationship. The interactions between cancer, plasma lipids and vitamin A, E could be modified by certain diets. However, further studies will be needed to elucidate these interactions.
D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D008055:Lipids / Q000097:blood*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000008:administration & dosage / Q000097:blood*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood*
D004041:Dietary Fats; D008055:Lipids; D014801:Vitamin A; D014810:Vitamin E; D008770:Methylnitrosourea