[Studies on a new mutagen produced by fusarium moniliforme isolated in Linxian County].
A new mutagen, Fusarin C has been recently isolated and identified from corn meal inoculated with Fusarium moniliforme, one of the most common fungus pollutant of corn in Linxian County, a high-risk area of esophageal cancer. Fusarin C significantly induced sister chromatid exchange (SCE), micronucleus increase, chromosome aberrations, and 6-thioguanine resistant mutants in V 79 cells in the presence of microsomal preparations. Fusarin C also induced 6-thioguanine resistant mutants in V 79 cells cocultured with primary rat liver cells. The toxic action of Fusarin C on V 79 cells was much stronger in the absence of the microsomal preparations. However, Fusarin C did not show, at the highest concentration, any significant mutagenic or chromosomal damage on V 79 cells without the addition of the metabolic activation system. The possible relationship between the consumption of corn contaminated with Fusarium moniliforme and the etiology of esophageal cancer is discussed.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations / Q000187:drug effects*; D002523:Edible Grain / Q000032:analysis; D005670:Fusarium / Q000032:analysis; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D011090:Polyenes / Q000302:isolation & purification / Q000633:toxicity*; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D009153:Mutagens; D011090:Polyenes; C041403:fusarin C