Uptake of proline by brushborder vesicles isolated from human kidney cortex.
Proline transport into renal brushborder membrane vesicles isolated from human kidney is mediated by two uptake systems. The high-affinity system is stimulated by a Na gradient and appears to be shared with glycine while the low-affinity system is not. Uptake curves of low concentrations of proline exhibit a Na-gradient-dependent overshoot indicative of electrogenic transport. The proline transport systems observed in isolated human renal brushborder membrane vesicles appear to have characteristics similar to those in rat kidney membranes.
D000409:Alanine / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism*; D011392:Proline / Q000378:metabolism*
D011392:Proline; D000409:Alanine; D006909:Hydroxyproline; D005998:Glycine