title: Contrasts between pindolol and propranolol concentration-response relationships.
abstract: The plasma concentration-response relationships of oral and intravenous pindolol and propranolol have been studied in a group of eight healthy male subjects who received each dosage form in a randomized single-blind cross-over manner. Despite similar elimination half-lives, the duration of action of pindolol was longer than that of propranolol. This longer duration of action was associated with a flatter concentration-response curve for pindolol and may be related to the partial agonist activity of pindolol. Propranolol concentration-response curves were dependent on the route of drug administration whereas pindolol curves were similar following oral and intravenous routes of administration.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010869:Pindolol / Q000008:administration & dosage / Q000097:blood*; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood*; D011897:Random Allocation
chemical_list: D011433:Propranolol; D010869:Pindolol