Correlation of bioscintigraphy, contrast venography, and iodine-125 fibrinogen uptake test.
In 40 patients believed to have deep venous thrombosis, bioscintigrams performed with I-123 fibrinogen were available for comparison with either contrast venograms or I-125 fibrinogen uptake tests. If either contrast venography or the fibrinogen uptake test was accepted as a standard for comparison, the accuracy of bioscintigraphic imaging was 90%. Most discrepancies between the procedures could be interpreted as due to heparin treatment, although bioscintigrams often were positive in patients treated with heparin for a short interval of time. Additionally, bioscintigrams provided information to distinguish venous thrombosis from other sources for local accumulation of radioactivity. Bioscintigraphy seems to be a promising noninvasive method for the detection of deep venous thrombosis of the lower extremities.
D000208:Acute Disease; D000328:Adult; D005260:Female; D005340:Fibrinogen; D006801:Humans; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000379:methods; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013924:Thrombophlebitis / Q000000981:diagnostic imaging*
D007457:Iodine Radioisotopes; D005340:Fibrinogen