title: Evaluation of the Cobasbact system for rapid antimicrobial susceptibility testing of positive blood culture broths.
abstract: The automated Cobasbact system was adapted for direct antimicrobial susceptibility testing of positive blood culture broths and its performance compared with that of the conventional Kirby-Bauer agar disc diffusion method using 278 positive blood samples. Overall, 1746 antibiotic-organism combinations were tested. Full agreement was 86.9% and essential agreement (i.e. including minor discrepancies) was 91.8%. The system would seem to produce acceptable susceptibility results within five hours after detection of a positive blood culture broth.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects; D005069:Evaluation Studies as Topic; D006801:Humans; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents