Changes in blood plasma and myocardial lipids in experimental thyrotoxic myocardial hypertrophy in rabbits.
Blood plasma and myocardial total lipids (TL), cholesterol (Ch), triglycerides (TGL), phospholipids (PhL), as well as plasma free fatty acids (FFA) were studied in 56 male rabbits with experimental thyrotoxic myocardial hypertrophy, induced by Thyreotom (group T14-14 days, T45-45 days). Combinations with Trasicor (TT-14 days) and aminooxyacetic acid (TAOAA-14 days) were also applied. The data showed a significantly lower plasma Ch and TL levels both in T14 and T45 as compared to the control group. The myocardial levels of TGL both in T14 and T45 were significantly higher than in the control group. In the TT group, myocardial Ch tended to decrease. A considerable decrease in plasma and myocardial lipids was found in the TAOAA group. Treatment with Thyreotom with or without Trasicor or AOAA resulted in a decrease of polyunsaturated FA, which was most expressed in the TT group. The combinations with Trasicor and AOAA had a protective effect on thyrotoxic disturbances.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006980:Hyperthyroidism / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010096:Oxprenolol / Q000494:pharmacology; D010743:Phospholipids / Q000097:blood; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D000625:Aminooxyacetic Acid; D010096:Oxprenolol; D002784:Cholesterol