Fusaric acid-induced elevation of homovanillic acid in the CSF as an index of brain noradrenaline synthesis.
The effect of the dopamine-beta-hydroxylase inhibitor, fusaric acid (FA), on cerebrospinal fluid (CSF) homovanillic acid (HVA) was studied in pentobarbitone-anesthetized rats. Idazoxan, a selective alpha 2-antagonist, accentuated the FA-induced HVA elevation in CSF while alpha-methyldopa pretreatment prevented this effect of FA on the HVA level in CSF. These results could indicate that the rate of dopamine synthesis in noradrenaline neurons could be the main determinant of the FA-induced HVA elevation.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D005669:Fusaric Acid / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis*; D010848:Picolinic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010848:Picolinic Acids; D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid; D009638:Norepinephrine; D006719:Homovanillic Acid