Relationship of stone growth and urinary biochemistry in long-term follow-up of stone patients with idiopathic hypercalciuria.
One hundred and twenty-four male stone formers with idiopathic hypercalciuria were followed up for 4 to 27 years (mean 12.2). Twenty-eight received restricted calcium diet alone, 52 also received bendrofluazide, 11 cellulose phosphate, and 33 received mixtures of those drugs. Although urinary calcium values fell in all groups, the stone recurrence rate remained unacceptably high. Patients on cellulose phosphate fared worst and this drug seems unsatisfactory as a sole agent. Urinary calcium was highest in patients without stone recurrences, but in patients with stone activity a higher stone recurrence rate was associated with higher urinary calcium and lower urinary volume.
D001539:Bendroflumethiazide / Q000627:therapeutic use; D002118:Calcium / Q000652:urine; D002128:Calcium Metabolism Disorders / Q000150:complications* / Q000188:drug therapy / Q000652:urine; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D012008:Recurrence; D014545:Urinary Calculi / Q000209:etiology* / Q000652:urine
D010070:Oxalates; D001539:Bendroflumethiazide; D002482:Cellulose; C008881:phosphocellulose; D019815:Oxalic Acid; D002118:Calcium