[Correlation of the results of in vitro tests (cell cultures and receptor analyses) of human breast cancers in relation to their hormone dependence].
Pretherapeutic parameters are demanded for the hormonal treatment of metastasing breast cancer. Many methods have proved to be ineffective in the assessment of the hormone sensitivity until now (determination of concentrations of steroid hormones in serum and urine or Barr's sex-chromatin). Investigations carried out hitherto on estradiol receptor content or on hormone sensitivity based on in-vitro cultures were promising. They caused us to compare both methods at the same mamma carcinoma tissue. The results of this study showed that no unequivocal correlation between receptor status and the results of in-vitro cell culture tests for hormone sensitivity could be found. Although all in all the results of both methods are almost identical in percentage, there are however substantial deviations between the results in the directly corresponding comparison of each single tissue sample.
D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy*; D002478:Cells, Cultured / Q000187:drug effects; D004351:Drug Resistance; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D011959:Receptors, Estradiol / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D004958:Estradiol
Korrelation der Ergebnisse von In-vitro-Tests (Zellkulturen und Rezeptoranalyse) menschlicher Mammakarzinome hinsichtlich ihrer Hormonabhängigkeit.