Early effects of 2-acetylaminofluorene and N-hydroxy-2-acetylaminofluorene on mitochondrial outer membrane enzyme activities of rat liver.
During the early stages of the carcinogen 2-acetylaminofluorene (2-AAF) feeding, there were marked decreases of hepatic mitochondrial type B monoamine oxidase (MAO) and kynurenine 3-hydroxylase activities in male rats, but not in female rats. The administration of N-hydroxy-2-AAF (N-OH-2-AAF), a proximate carcinogenic metabolite of 2-AAF, to male rats also resulted in the decrease of both enzyme activities. The findings indicate that type B MAO and kynurenine 3-hydroxylase which reside in the outer mitochondrial membranes are susceptible to 2-AAF during the early stages of its hepatocarcinogenesis.
D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006881:Hydroxyacetylaminofluorene / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000201:enzymology; D050601:Kynurenine 3-Monooxygenase; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009245:NADH Dehydrogenase / Q000378:metabolism; D051381:Rats; D012402:Rotenone / Q000494:pharmacology; D013997:Time Factors
D012402:Rotenone; D006881:Hydroxyacetylaminofluorene; D015073:2-Acetylaminofluorene; D006899:Mixed Function Oxygenases; D050601:Kynurenine 3-Monooxygenase; D008995:Monoamine Oxidase; D009245:NADH Dehydrogenase