Evaluation of the affinity of new N atom-containing tumor inhibitors for nucleic acids.
Interaction between new N atom-containing tumor inhibitors (1-9) and nucleic acids has been investigated utilizing the spectroscopic methods efficiently. On the basis of their data, it is well suggested that FNT-4 (4) and benzo[c]phenanthridine alkaloids (6-8) bind to nucleic acids by a fashion involving intercalation of aromatic molecule(s).
D000818:Animals; D000970:Antineoplastic Agents; D002417:Cattle; D004247:DNA; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013950:Thymus Gland
D000970:Antineoplastic Agents; D004247:DNA