title: Bioavailability of indomethacin after intramuscular injection and rectal administration of solution and suppositories.
abstract: The pharmacokinetics of indomethacin was studied after intravenous and intramuscular injection of 50 mg and administration of rectal solution and suppositories of 100 mg to 8 volunteers. Peak plasma concentrations of indomethacin occurred 20 min. after administration of the rectal solution (3.7 micrograms X ml-1), 40 min. after intramuscular injection (2.7 micrograms X ml-1), and 60 min. after suppositories (3.7 micrograms X ml-1). The bioavailability after the two rectal forms was found to be almost the same, about 80%. After intramuscular injection the bioavailability was calculated to be complete. These results suggest that indomethacin administered as a rectal solution or as intramuscular injection may be an alternative to intravenous administration when an early plasma peak of the drug is required.
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013488:Suppositories
chemical_list: D013488:Suppositories; D007213:Indomethacin