Antihepatotoxic principles of Phyllanthus niruri herbs.
Among phyllanthin, hypophyllanthin, triacontanal and tricontanol isolated from a hexane extract of Phyllanthus niruri, phyllanthin and hypophyllanthin protected against carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes, while triacontanal was protective only against galactosamine-induced toxicity.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D005688:Galactosamine / Q000633:toxicity; D017705:Lignans / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D017705:Lignans; D010936:Plant Extracts; D005688:Galactosamine; C517985:phyllanthin