Prevalence of gestational and perinatal insults in brain-damaged children.
The value of utilizing the analysis of unusual dermatoglyphic patterns and of microscopic dental enamel abnormalities as nonspecific registers of fetal and perinatal insult was investigated in brain-damaged children. Positive findings were demonstrated in 82% of the brain-damaged group and in 17% of healthy controls (P less than 0.001). This confirms that most brain damage in children occurs during pregnancy. The limited correlation between recorded potential damaging events during pregnancy and the appropriate markers of fetal/perinatal insult suggests that the data available are inadequate for identifying the causes of brain damage. The implications of these observations are discussed with regard to determining the etiology of brain damage.
D001925:Brain Damage, Chronic / Q000151:congenital / Q000209:etiology* / Q000473:pathology; D002648:Child; D003744:Dental Enamel Hypoplasia / Q000473:pathology*; D003878:Dermatoglyphics; D005314:Embryonic and Fetal Development; D005260:Female; D005315:Fetal Diseases / Q000150:complications*; D006801:Humans; D011247:Pregnancy; D011295:Prenatal Care