title: Anticoagulant action of synthetic tight binding inhibitors of thrombin in vitro and in vivo.
mesh_terms: D000818:Animals; D000925:Anticoagulants; D001667:Binding, Competitive; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D004151:Dipeptides; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010880:Piperidines / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D004151:Dipeptides; D010880:Piperidines; C038708:N(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide; C047486:N(alpha)-tosylglycyl-4-amidinophenylalanine piperidide; D013917:Thrombin