A novel macromolecular antibiotic, SN-07. Taxonomy of producing organism, isolation, characterization and biological activities.
A novel macromolecular antibiotic SN-07 was obtained from the cultural supernatant of Actinomadura roseoviolacea var. miuraensis nov. var. The antibiotic was soluble in water, had a molecular weight of 18,000-22,000 daltons in 50 mM Tris-HCl buffer, pH 7.0, containing 2.0 M KCl as compared with authentic proteins. Its major constituents were nucleic acids. The substance had antibacterial activity against Gram-positive bacteria. It was also effective against lymphocytic leukemia P388 in vivo.
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009696:Nucleic Acids / Q000302:isolation & purification / Q000494:pharmacology
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009696:Nucleic Acids; C047795:SN-07