title: Abnormal erythrocyte survival in patients with myotonic dystrophy.
abstract: In four of six patients with myotonic dystrophy whom we studied 51Cr labeled erythrocytes were found to have a biphasic survival kinetic. After in initial significantly more rapid disappearance than in controls, about 80% of the labeled cells reappeared in circulation, and were thereafter eliminated at a significantly faster rate than normal. This type of biphasic survival pattern may partly be related to reduced sialic acid concentration of the erythrocyte membrane in patients with this disease.
mesh_terms: D004905:Erythrocyte Aging; D006801:Humans; D009223:Myotonic Dystrophy / Q000097:blood*