Estrogen use and cardiovascular disease.
In general, epidemiologic data from case-control and cohort studies have suggested that postmenopausal estrogen use confers a moderate degree of protection from coronary artery disease (CAD). Reductions have been found in all-cause mortality and mortality from acute myocardial infarction among estrogen replacement users as compared with never-users. Even a small decline in the death rate from CAD among estrogen users would have a major impact on the overall risk:benefit ratio associated with estrogen use.
D000368:Aged; D002979:Climacteric / Q000187:drug effects*; D003327:Coronary Disease / Q000517:prevention & control*; D045166:Estradiol Congeners / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control; D045167:Progesterone Congeners / Q000627:therapeutic use; D011446:Prospective Studies; D012306:Risk
D045166:Estradiol Congeners; D045167:Progesterone Congeners