Identification and characterization of the human hepatic androgen receptor.
Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) present in cytosol alone and a low molecular weight component (mol wt. 75 000) present in cytosol and nucleosol. Human liver contains the classical androgen receptor.
D002467:Cell Nucleus / Q000032:analysis; D002850:Chromatography, Gel; D003600:Cytosol / Q000032:analysis; D005260:Female; D006801:Humans; D008099:Liver / Q000032:analysis* / Q000166:cytology / Q000378:metabolism; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives / Q000378:metabolism; D011485:Protein Binding; D011944:Receptors, Androgen / Q000302:isolation & purification* / Q000378:metabolism
D011944:Receptors, Androgen; D009277:Nandrolone; C100075:mibolerone