title: Premature thelarche: a follow up study of 40 girls. Natural history and endocrine findings.
abstract: Follow up of 40 girls with premature thelarche showed that where this disorder occurred before age 2 years it usually regressed completely, thus representing a transient and isolated phenomenon. Premature thelarche after age 2 years persisted more frequently, however, and represented the first sign of sexual development, generally leading to simple early puberty.
mesh_terms: D000367:Age Factors; D001827:Body Height; D001940:Breast / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011627:Puberty
chemical_list: D006062:Gonadotropins