Autoradiographic binding studies with [3H]oestradiol and [3H]dihydrotestosterone in the autonomic genital ganglion (plexus of Frankenhäuser) of the mouse.
Male, female and Tfm mice (testicular feminization) were injected with [3H]oestradiol or [3H]dihydrotestosterone, and autoradiograms prepared of male accessory sex organs and of the cervico-vaginal portion of the female reproductive tract. After injection of [3H]oestradiol in male, female and Tfm animals a nuclear concentration of radioactivity was found in a subpopulation--about 20-30%--of the neurons of the genital ganglion. No such concentration was seen after [3H]dihydrotestosterone. The results suggest a direct genomic effect of oestradiol on certain neurons of the autonomic genital ganglion in both sexes.
D013734:Androgen-Insensitivity Syndrome / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D013196:Dihydrotestosterone / Q000008:administration & dosage; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D005725:Ganglia, Autonomic / Q000378:metabolism*; D005836:Genitalia, Female / Q000294:innervation / Q000378:metabolism*; D005837:Genitalia, Male / Q000294:innervation / Q000378:metabolism*; D008297:Male; D051379:Mice; D011944:Receptors, Androgen / Q000378:metabolism*; D011959:Receptors, Estradiol / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
D011944:Receptors, Androgen; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D013196:Dihydrotestosterone; D004958:Estradiol