Bombesin and litorin inhibit ethanol intake.
Twenty-three hr water-deprived rats received access to 5% ethanol solution for 30 min daily. Intraperitoneal injection of bombesin (4.0-16.0 micrograms/kg) or litorin (16.0 micrograms/kg) significantly inhibited ethanol intake. Litorin (32.0 micrograms/kg) equivalently suppressed the intakes of 5% ethanol and 8.9% dextrose solutions. The results are consistent with previous reports that administration of bombesin-like peptides selectively inhibits caloric intake in the rat. Injection of bombesin-like peptides may affect ethanol and dextrose intake by eliciting a satiety signal that governs caloric intake.
D000428:Alcohol Drinking; D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014868:Water Deprivation
D009842:Oligopeptides; C010212:litorin; D001839:Bombesin