Effect of experimental vascular occlusion on small intestinal motility in ponies.
Small intestinal ischaemia is a cause of pain in man and horses. Occlusion of the vascular supply to Thiry loops in experimental ponies caused severe discomfort and loss of motility within a few minutes but these effects could not be reproduced by a similar procedure in intact gut preparations. However, embolisation of the mural vascular network produced ischaemia of the small intestine of anaesthetised ponies which led to a cessation of motility in the affected segments, though unaffected segments became hypermotile with a characteristic motility pattern. These results suggest the need for reappraisal of the classical theory of parasite-induced damage to the cranial mesenteric artery as the cause of ischaemic bowel disease.
D000818:Animals; D004617:Embolism / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006736:Horses; D007082:Ileum / Q000098:blood supply*; D007511:Ischemia / Q000503:physiopathology*; D007583:Jejunum / Q000098:blood supply*