Methylthio-capping of selenocysteamine: preliminary studies on selective toxicity for cancer chemotherapy.
Dimethyl disulfide markedly increased the cytotoxicity of selenocystamine by 2 orders of magnitude, from 40 microM to 0.5 microM for 50% inhibition of growth in 45 hr. When mice were injected ip with 22 microMole/Kg of selenocystamine on Day 0, all were dead on Day 4. If dimethyl disulfide (500 microMole/Kg) was either mixed with the selenocystamine or injected immediately prior to it, the mice survived treatment for at least 21 days afterwards, suggesting that methylthio-capping of selenocysteamine reduced host toxicity. Such combined treatment may be of value in chemotherapy.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D003538:Cystamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D004220:Disulfides / Q000378:metabolism / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D016566:Organoselenium Compounds; D012643:Selenium / Q000378:metabolism / Q000633:toxicity*
D004220:Disulfides; D016566:Organoselenium Compounds; C014807:selenocystamine; C021181:dimethyl disulfide; D012643:Selenium; D003538:Cystamine