[Comparative study of the antiviral activity of natural double-stranded RNAs in experimental tick-borne encephalitis].
A comparative study of the antiviral effect of interferon inducers from the group of natural double-stranded RNAs (yeast plasmid dsRNA, phage phi 6 and phage f2 dsRNAs was carried out on the model of experimental tick-borne encephalitis. The possibility of inducing up to 60% protection against 10 LD50 of TBE virus by prophylactic inoculation of interferon inducers alone was demonstrated. The therapeutic effect was observed only with yeast dsRNA (30% protection when the inducer was administered 4 hours after virus infection of mice). The prophylactic effect of inoculation of interferon inducers (yeast dsRNA and f2 dsRNA) to immune mice correlated with the protective effect of inducers alone. At the same time, the therapeutic effect of inoculation of yeast dsRNA to immune animals (4 hours after TBE virus, 40% protection) was more marked. In the therapeutic use of f2 dsRNA for pre-immunized animals a synergetic effect of the preparation was observed (56.7% protection in 4 hours and 26.7% protection 24 hours postinfection).
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D004675:Encephalitis, Tick-Borne / Q000188:drug therapy*; D007369:Interferon Inducers / Q000627:therapeutic use; D051379:Mice; D010957:Plasmids; D012330:RNA, Double-Stranded / Q000627:therapeutic use*; D012331:RNA, Fungal / Q000627:therapeutic use; D012367:RNA, Viral / Q000627:therapeutic use; D013997:Time Factors; D014765:Viral Vaccines / Q000627:therapeutic use
D000998:Antiviral Agents; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D012367:RNA, Viral; D014765:Viral Vaccines
Sravnital'noe izuchenie protivovirusnoĭ aktivnosti prirodnykh dvuspiral'nykh RNK pri éksperimental'nom kleshchevom éntsefalite.