Inhibition of chlorophyll synthesis in Hordeum vulgare by 3-amino 2,3-dihydrobenzoic acid (gabaculin).
Gabaculin (3-amino 2,3-dihydrobenzoic acid) is shown to be a very potent inhibitor of chlorophyll formation in Hordeum vulgare. Exposure of leaf segments to 30 microM gabaculin results in an 80% inhibition of chlorophyll synthesis, and this is paralleled by a decrease in carotenoid. Dual-inhibitor studies with dioxoheptanoic acid, which is an inhibitor of delta-amino-laevulinic acid dehydratase, show that gabaculin inhibits an earlier step than dioxoheptanoic acid and affects delta-amino-laevulinic acid synthesis rather than its subsequent metabolism.
D000622:Aminolevulinic Acid / Q000378:metabolism; D002734:Chlorophyll / Q000096:biosynthesis*; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D001467:Hordeum; D010944:Plants
D003509:Cyclohexanecarboxylic Acids; D002734:Chlorophyll; C012987:gabaculine; D000622:Aminolevulinic Acid