Chlorambucil in the treatment of intractable Uveitis associated with juvenile chronic arthritis.
The response to prolonged low dose chlorambucil for chronic active uveitis in 6 patients with juvenile chronic arthritis and one patient with juvenile ankylosing spondylitis is described. Only 2 patients were judged to have had longterm benefit from treatment in both eyes and one had a transient benefit in one eye. Drug induced adverse effects occurred in 3 patients.
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications*; D001853:Bone Marrow / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006562:Herpes Zoster / Q000209:etiology; D006801:Humans; D008297:Male; D010053:Ovary / Q000187:drug effects; D013167:Spondylitis, Ankylosing / Q000150:complications; D014606:Uveitis, Anterior / Q000150:complications / Q000188:drug therapy*
D002699:Chlorambucil