title: Investigation of phenanthroquinolizidine analogues. Synthesis and biological activity of substituted 9-sec-amino- and tert-aminophenanthrenes.
abstract: A series of 9-tert-aminomethylphenanthrenes substituted with various groups in various positions were prepared, and their fungicidal effects were examined. Comparative studies were made with phenanthroquinolizidines, which are strong fungicides. Opening of the quinolizidine skeleton was found to be accompanied by a substantial decrease in the effect. This is considered to be connected with the change in position (orientation) of the nitrogen relative to the phenanthrene skeleton.
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011807:Quinolizines / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D010616:Phenanthrenes; D011807:Quinolizines