Structure of inclusion complexes of cyclomaltoheptaose (cycloheptaamylose): crystal structure of the 1-adamantanemethanol adduct.
Cyclomaltoheptaose (cycloheptaamylose) has been crystallized with 1-adamantanemethanol as the guest molecule. The complex crystallized in space group C222(1), with unit-cell dimensions a = 19.162 (13), b = 23.965 (17), and c = 32.597 (27) A. The structure was solved by rotation-translation search-methods. The cyclomaltoheptaose exists as a dimer in the crystal by means of extensive hydrogen-bonding across the secondary hydroxyl ends of two cyclomaltoheptaose molecules. The two halves of the dimer are related by a crystallographic two-fold axis. The primary hydroxyl ends of two adjacent cyclomaltoheptaose molecules are also related by a crystallographic two-fold axis, but do not directly hydrogen bond to one another. Instead, they are held in place by a strong hydrogen bond from the hydroxyl group of the 1-adamantanemethanol to a primary hydroxyl group on an adjacent cyclomaltoheptaose molecule. Other stabilizing hydrogen bonds are formed via three water molecules which are situated at the primary hydroxyl interface, and others that form parallel columns stabilizing the crystal structure. A unique feature of this complex is the presence of trapped water in the cavity at the secondary hydroxyl interface. This water is distributed over 3 disordered sites. Its presence blocks one possible site for the 1-adamantanemethanol, which, instead, binds near the primary hydroxyl end, with its hydroxyl group and part of the adamantane moiety protruding from the cyclomaltoheptaose.
D000218:Adamantane / Q000031:analogs & derivatives*; D002236:Carbohydrate Conformation; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D003505:Cyclodextrins; D003912:Dextrins; D006860:Hydrogen Bonding; D008958:Models, Molecular; D013213:Starch
D003505:Cyclodextrins; D003912:Dextrins; C047128:cyclomaltoheptaose-1-adamantanemethanol; D013213:Starch; D000218:Adamantane