Effect of sustained-release on the pharmacokinetics of theophylline in healthy subjects.
The effect of sustained-release on the pharmacokinetics of theophylline was examined by comparing two sustained-release formulations (Theo-Dur and Theotard) to an oral solution and i.v. preparation of the drug. Drug-level monitoring was performed by an HPLC assay. The absorption profiles of the three oral formulations were pharmacokinetically analyzed by using the Loo-Riegelman procedure. The absorption of theophylline after the administration of the Theo-Dur and Theotard was found to be of an apparent zero-order kinetics.
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D003692:Delayed-Action Preparations; D013806:Theophylline