[Calcium-regulating hormones and functional activity of the myocardium during beta-adrenoreceptor block by inderal].
Effect of calcitonin (CT) upon the AP of contractile cardiomyocytes was absent under conditions of blockade of beta-adrenoreceptors with inderal which reduced the level of intracellular sodium and ionized calcium. Inderal facilitated the effect of parathyroid hormone on the myocardium electrical activity. In conditions of blockade of beta-adrenoreceptors, the CT acted upon the autorhythmic activity of pace-maker cardiomyocytes as in control solution.
D000200:Action Potentials / Q000187:drug effects; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001001:Anura; D002116:Calcitonin / Q000494:pharmacology*; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits
D010281:Parathyroid Hormone; D002116:Calcitonin; D011433:Propranolol; D000262:Adenylyl Cyclases
Kal'tsiĭreguliruiushchie gormony i funktsional'naia aktivnost' miokarda v usloviiakh blokady beta-adrenoretseptorov inderalom.