Spontaneous regression of unilateral retinoblastoma in a father of three sons with bilateral retinoblastoma.
Three brothers had bilateral retinoblastoma: one other sibling, a girl, had normal eyes. The parents were second cousins once removed. The father's right divergent eye, 'amblyopic' from childhood, showed a large atrophic patch in the macular area, probably a spontaneously resolved retinoblastoma.
D000328:Adult; D002648:Child; D003241:Consanguinity; D005134:Eye Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D012075:Remission, Spontaneous; D012175:Retinoblastoma / Q000235:genetics* / Q000473:pathology; D012737:Sex Factors