Effect of probucol on triton induced hyperlipidemias in CFY rats.
The two phases of triton test have been used to find out the effect of probucol to evaluate whether it is effective cholesterol lowering agent prophylactically or therapeutically. Probucol is shown to be a better accelerator for lipid clearance in triton hyperlipidemia than clofibrate. The clearance rate of VLDL is more than that of LDL. In the first phase of triton test probucol has more effect on cholesterol synthesis than triglycerides while in the second phase of triton test probucol has more effect as a clearing agent on triglycerides than on cholesterol.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000175:diagnosis / Q000188:drug therapy*; D000960:Hypolipidemic Agents; D008297:Male; D010636:Phenols / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000037:antagonists & inhibitors; D011341:Probucol / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000960:Hypolipidemic Agents; D010636:Phenols; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; D002994:Clofibrate; D011341:Probucol