The change of p-aminohippuric acid disposition kinetics accompanied by growth in mice.
The change of disposition kinetics for p-aminohippuric acid (PAH) was studied following intravenous administration of p-[glycyl-1-14C]aminohippuric acid to 1-day-old, 1-week-old, 3-week-old and 8-week-old mice. The expiratory excretion of 14CO2 in 24 h following the administration was almost negligible in 1-day-old and 1-week-old mice in contrast to 3-week-old (6.8 +/- 1.8%) and 8-week-old (8.8 +/- 1.9%) mice. The ability to metabolize PAH may not be developed in these infant mice. The elimination of blood radioactivity following the administration was considerably delayed in 1-day-old and 1-week-old mice, especially in 1-day-old mice, suggesting that the renal tubular secretory function for PAH might not have been developed in the infant mice. Whole-body autoradiographic data showed that the transfer of PAH from blood to muscle was enhanced in 1-day-old and 1-week-old mice, especially in 1-day-old mice, compared to 3-week-old and 8-week-old mice. The enhanced muscular cell membrane permeability to PAH in 1-day-old and 1-week-old mice was considered to be the most plausible explanation for this result.
D000367:Age Factors; D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001345:Autoradiography; D002855:Chromatography, Thin Layer; D005243:Feces / Q000032:analysis; D005260:Female; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051379:Mice; D009132:Muscles / Q000098:blood supply; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration; D014018:Tissue Distribution; D010130:p-Aminohippuric Acid / Q000097:blood / Q000378:metabolism* / Q000652:urine
D000618:Aminohippuric Acids; D010130:p-Aminohippuric Acid