Finite dose pharmacokinetics of skin penetration.
A model for estimating in vivo skin permeability coefficients for finite doses is presented. The ratio of the maximum value of the excretion rate to the steady-state flux is a function of the thickness of the applied vehicle and the vehicle-skin partition coefficient. The decay rate of the excretion is a function of skin-vehicle parameters for large doses and, under certain conditions, can even reduce to the total excretory rate constant as the dose is decreased.
D002626:Chemistry, Pharmaceutical; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism* / Q000652:urine; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption
D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles