Antiinflammatory effect of the antioxidant MTDQ-DS.
The effects of native and oxidized forms of the new antioxidant drug MTDQ-DS (HUMAN, Hungary) on some parameters of acute inflammatory processes were studied. In short-term in vitro experiments, both forms at 10(-4) to 10(-6) g/l inhibited dose-dependently the zymosan-induced chemotaxis of the rat peritoneal polymorphonuclear (PMN) granulocytes. In short-term in vivo experiments both forms administered intraperitoneally at 450 or 600 mg/kg inhibited the formation of carrageenin oedema in the rat paw. The long-term administration for 3 weeks of native and oxidized MTDQ-DS in doses of 450 mg/kg significantly inhibited the carrageenin-induced oedema formation, the zymosan-induced chemotaxis, and the luminol-dependent light production of rat peritoneal PMN granulocytes. The results suggest that the native and oxidized forms of MTDQ-DS have an antiinflammatory effect since they inhibit several events in the local inflammatory reaction.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D015054:Zymosan / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D011804:Quinolines; D002351:Carrageenan; D015054:Zymosan; C044964:6,6'-methylenebis(2,2-dimethyl-4-methanesulfonic acid-1,2-dihydroquinoline)