In vivo experiments with powder charcoal haemoperfusion (filmadsorber) in a pig model of hepatic failure.
The filmadsorber, an experimental haemoperfusion column containing activated powder charcoal embedded in a colloidal film, has been tested in pigs with ischaemicnecrosis of the liver. Haemoperfusion with a flow of 200 ml/min was performed for a duration of 4 to 6 hours. Bile acid clearances varied between +/- 52 ml/min (1st hour) and +/- 23 ml/min (6th hour). Clearances for aromatic amino acids were initially even higher (phenylalanine 115, tyrosine 112 and methionine 46 ml/min). No ammonia was removed. Side-effects were minimal, although platelets fell 24 +/- 15%. We conclude that haemoperfusion with the filmadsorber is well tolerated and associated with high clearances for bile acids and some amino acids, particularly in the first hours of treatment.
D000208:Acute Disease; D000327:Adsorption; D000596:Amino Acids / Q000097:blood; D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood; D001672:Biocompatible Materials; D002606:Charcoal; D004195:Disease Models, Animal; D006400:Hematocrit; D006464:Hemoperfusion / Q000295:instrumentation; D007511:Ischemia / Q000097:blood / Q000628:therapy; D008099:Liver / Q000098:blood supply; D008107:Liver Diseases / Q000097:blood / Q000628:therapy*; D009336:Necrosis; D010976:Platelet Count; D013552:Swine
D000596:Amino Acids; D001647:Bile Acids and Salts; D001672:Biocompatible Materials; D002606:Charcoal