Anti-inflammatory effect of intraventricularly administered histamine in rats.
Intracerebroventricularly (icv) administered histamine (5, 10 and 20 micrograms) produced a dose-related anti-inflammatory effect against carrageenin-induced pedal edema in rats. The effect of histamine was mimicked by the H1 receptor agonist, 2-methylhistamine, but not by the H2 receptor agonist, 4-methylhistamine. The anti-inflammatory effect of centrally administered histamine was antagonised by mepyramine, a H1 receptor antagonist, but not by cimetidine, a H2 receptor antagonist. The anti-inflammatory effect of icv histamine was inhibited in bilaterally adrenalectomised rats but was unaffected by peripheral chemical sympathectomy induced by 6-hydroxydopamine.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002351:Carrageenan; D005260:Female; D006632:Histamine / Q000008:administration & dosage*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007276:Injections, Intraventricular; D008297:Male; D008761:Methylhistamines / Q000008:administration & dosage; D011738:Pyrilamine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D008761:Methylhistamines; D006632:Histamine; D002351:Carrageenan; C026259:2-methylhistamine; D011738:Pyrilamine