The myth of long-term thiazide-induced magnesium deficiency.
A group of 8 patients with essential hypertension and 12 patients with recurrent renal calcium stones were treated with 50 mg hydrochlorothiazide daily for a period of 3-10 years. Serum, erythrocyte, lymphocyte, skeletal muscle, bone and urine Mg were found to be within the normal range. In the intravenous Mg load test, all patients retained a normal percentage of the loading dose of Mg. Long-term thiazide therapy does not appear to lead to Mg depletion.
D001842:Bone and Bones / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007669:Kidney Calculi / Q000188:drug therapy / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008275:Magnesium Deficiency / Q000139:chemically induced*; D009132:Muscles / Q000378:metabolism; D013997:Time Factors
D006852:Hydrochlorothiazide; D008274:Magnesium