Cytostatic activity in vitro of phosphonic acid derivatives.
Cytostatic activity of 48 new amino acid analogs and derivatives of phosphonic acid type was tested against KB cell line in vitro. The tests were performed according to the recommended international protocol for screening of chemical agents against tissue culture system. Three of the compounds tested: No. No, 29, 33 and 32 revealed cytostatic activity at the concentrations: 63, 150, and 180 micrograms ml-1 respectively (ID50).
D000596:Amino Acids / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000166:cytology / Q000187:drug effects; D007700:Kinetics; D063065:Organophosphonates / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000596:Amino Acids; D063065:Organophosphonates