A histomorphometric analysis of subchondral bone in juvenile arthropathy of the dog knee.
Subchondral bone changes in arthropathy were investigated in an animal model using mongrel dog knees. Unilateral arthritis of the knee was induced by repeated intra-articular instillations of Carrageenin solution in 14 mongrel puppies. Histomorphometric analysis of cartilage and bone was performed blindly in both knees of each dog. Arthritis resulted in a significant increase in the joint cartilage thickness and a significant decrease in subchondral epiphyseal trabecular bone volume (VTB%) and trabecular thickness (TRTH), suggesting negative bone balance. No significant changes in osteoid surfaces (OS%) and resorptive surfaces (RS%) were found. The dynamic parameters suggest an increased bone turnover in the arthritic subchondral bone.
D000818:Animals; D001171:Arthritis, Juvenile / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D002356:Cartilage / Q000473:pathology; D004285:Dogs; D007719:Knee Joint / Q000473:pathology; D010012:Osteogenesis; D011453:Prostaglandins / Q000502:physiology
D011453:Prostaglandins