The effect of Cernitins on galactosamine-induced hepatic injury in rat.
Cernitins correspond to microbiologically fermented pollen extract. Cernitin T60 contains mainly water soluble, while Cernitin GBX mainly fat soluble substances. The aim of the present work was to examine the effect of Cernitins on the d-galactosamine-induced liver damage in rat. It has been shown, that galactosamine administration to rat resembles viral hepatitis both biochemically and histologically. Our studies proved, that Cernitin T60 given orally or intraperitoneally inhibited or counteracted the elevation of amino transferases activity and the inflammatory process, necrosis and steatosis of the liver cells. The protective effect of Cernitin GBX on the liver parenchyma was only slightly expressed. It is concluded, that application of pollen extracts in patients with liver diseases should be considered.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000473:pathology; D005688:Galactosamine / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis; D010936:Plant Extracts; D011058:Pollen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012434:Secale
D010936:Plant Extracts; D005688:Galactosamine; C010070:cernilton