Separating the effects of lead and social factors on IQ.
Initial evaluations of 104 low-socioeconomic status black children screened by the local community health departments in North Carolina showed significant effects of lead in the range 6-59 micrograms/dl on IQ after controlling for concomitant social factors, such as socioeconomic status, home environment, and maternal IQ. The main concomitant variable was socioeconomic status, which was multicolinear with other social factors. Five years later, when all blood lead levels were 30 micrograms/dl or less, lead effects on IQ were no longer significant. The correlation between maternal and child IQ, which had been suppressed initially in children with higher lead levels, returned to expected levels when decreases in blood lead level occurred, while concomitant variables remained stable over the 5-year period.
D002648:Child; D002657:Child Development / Q000187:drug effects; D002675:Child, Preschool; D004781:Environmental Exposure; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007360:Intelligence / Q000187:drug effects*; D007361:Intelligence Tests; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000523:psychology*; D009657:North Carolina; D012959:Socioeconomic Factors
D007854:Lead