[Synthesis and positive inotropic action of some 5-substituted 5H-(1)benzopyrano(4,3-b)pyridines].
The 5-hydroxy-5H-[1]benzopyrano [4,3-b]pyridines (4) were converted to the acetales 7-10 on treatment with alcoholic solutions in the presence of concentrated hydrochloric acid. Reactions of with aliphatic and aromatic amines yielded the aminoacetales 11-15. The effects of compounds 7-15 were examined on the isolated perfused guinea-pig heart.
D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D001578:Benzopyrans; D002316:Cardiotonic Agents; D011725:Pyridines; D007545:Isoproterenol
Synthese und positiv inotrope Wirkung einiger 5-substituierter 5H-[1]benzopyrano[4,3-b]pyridine.