title: Sialyltransferase: regulation of alpha-foetoprotein microheterogeneity during development.
abstract: The temporal accumulation of the electrophoretic components of mouse alpha-foetoprotein in foetal plasma and amniotic fluid is reported. To explain the progressive appearance of the sialylated alpha-foetoproteins, the activity of sialyltransferase in foetal liver and yolk sac was measured. These results indicate that the increase in sialyltransferase activity in these tissues is responsible for the increased sialylation of alpha-foetoprotein.
mesh_terms: D000510:Alpha-Globulins / Q000032:analysis*; D000653:Amniotic Fluid / Q000032:analysis; D000818:Animals; D002417:Cattle; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D005333:Fetus / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D051379:Mice; D009438:Neuraminic Acids; D011247:Pregnancy; D014166:Transferases / Q000032:analysis*; D014817:Vitelline Membrane / Q000201:enzymology
chemical_list: D000510:Alpha-Globulins; D005326:Fetal Proteins; D009438:Neuraminic Acids; D014166:Transferases