Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody.
The idiotype of the mouse myeloma protein with anti-alpha-1,3 dextran activity, J558, has been characterized by a solid-phase radioimmunoassay. The idiotype of the J558 protein depends on a specific light and heavy chain interaction and is altered in the presence of the hapten, nigerose. Cross-reacting idiotypes were found on another mouse myeloma protein with alpha1,3 dextran specificity, normal anti-dextran antibody, and certain reconstructed myeloma proteins composed of the J558 heavy chain and heterologous light chains.
D000595:Amino Acid Sequence; D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions / Q000187:drug effects; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D003429:Cross Reactions; D003911:Dextrans; D004187:Disaccharides / Q000494:pharmacology; D000939:Epitopes; D005815:Genetic Code; D006241:Haptens; D007456:Iodine Isotopes; D008320:Maltose / Q000494:pharmacology; D051379:Mice / Q000276:immunology; D009194:Myeloma Proteins / Q000032:analysis* / Q000302:isolation & purification; D009374:Neoplasms, Experimental; D010954:Plasmacytoma; D011863:Radioimmunoassay
D003911:Dextrans; D004187:Disaccharides; D000939:Epitopes; D006241:Haptens; D007456:Iodine Isotopes; D009194:Myeloma Proteins; D008320:Maltose