DNA polymerases from RNA tumor viruses and human cells: inhibition by polyuridylic acid.
Polyuridylic acid inhibited DNA polymerases purified from three species of oncornaviruses as well as three out of seven DNA polymerases purified from cells. Viral and cellular DNA polymerases could not be distinguished by polyuridylic acid inhibition, but were easily distinguished by their template preferences in the presence of magnesium.
D000818:Animals; D001354:Avian Leukosis Virus / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D000882:Haplorhini; D006801:Humans; D007700:Kinetics; D007945:Leukemia, Lymphoid / Q000201:enzymology; D008214:Lymphocytes / Q000201:enzymology; D051379:Mice; D009858:Oncogenic Viruses / Q000201:enzymology*; D011119:Polynucleotides / Q000378:metabolism / Q000494:pharmacology*; D012328:RNA Viruses / Q000201:enzymology*; D012194:RNA-Directed DNA Polymerase / Q000302:isolation & purification / Q000378:metabolism; D011925:Rauscher Virus / Q000201:enzymology; D018894:Reverse Transcriptase Inhibitors; D013698:Templates, Genetic; D014500:Uracil Nucleotides / Q000494:pharmacology*
D011119:Polynucleotides; D018894:Reverse Transcriptase Inhibitors; D014500:Uracil Nucleotides; D004247:DNA; D004254:DNA Nucleotidyltransferases; D012194:RNA-Directed DNA Polymerase