Mixed lymphocyte culture responses of mice. Genetic analysis of the responses to H-2Dd specificities.
Cellular responses in vitro to H-2D region histocompatibility antigens were demonstrated to be under the genetic control of two or three (P = 0.013) independently segregating loci. The H-2 region itself accounts for one of these loci, however, its activity appears to be dependent upon an association with other non-H-2-associated genetic information. The ability to stimulate a response and to respond to that stimulus are two separate genetic functions in certain MLR combinations. The stimuli in our studies were products of the H-2D region and cell donors must differ at that region in order for a response to occur. The control of the level of responses was determined by other genetic material. Differences at these "response loci" were not necessary for the induction of a proliferative response in the mixed lymphocyte cultures.
D000483:Alleles; D000818:Animals; D000939:Epitopes; D005799:Genes, Dominant; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D007125:Immunogenetics; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D011995:Recombination, Genetic
D000939:Epitopes; D006649:Histocompatibility Antigens