Cytochalasin B prevents specific sorting of reaggregating embryonic cells.
The effect of cytochalasin B on specific sorting during reaggregation of embryonic chick heart and neural retina cells was studied. At a dose that did not measurably affect uptake of precursors of protein and RNA synthesis, ratios of potassium to sodium ions, and nonspecific aggregation, cytochalasin B disrupted the formation of the characteristic pattern of islands of heart cells within a retinal continuum.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes; D002449:Cell Aggregation / Q000187:drug effects*; D002642:Chick Embryo; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006321:Heart / Q000196:embryology; D009183:Mycotoxins / Q000494:pharmacology*; D009206:Myocardium / Q000166:cytology; D011188:Potassium / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012160:Retina / Q000166:cytology / Q000196:embryology; D012964:Sodium / Q000378:metabolism; D013194:Staining and Labeling; D014529:Uridine / Q000378:metabolism
D000596:Amino Acids; D002247:Carbon Isotopes; D009183:Mycotoxins; D012313:RNA; D012964:Sodium; D011188:Potassium; D014529:Uridine; D004121:Dimethyl Sulfoxide