Dual effect of 5-azacytidine on the synthesis of liver ribonucleic acids. Lack of the relationship between metabolic transformation of orotic acid in vitro and its incorporation in vivo.
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D001711:Biotransformation / Q000187:drug effects; D002247:Carbon Isotopes; D002262:Carboxy-Lyases / Q000032:analysis; D002474:Cell-Free System / Q000187:drug effects; D003562:Cytidine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007553:Isotope Labeling; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009963:Orotic Acid / Q000378:metabolism*; D010430:Pentosyltransferases / Q000032:analysis / Q000037:antagonists & inhibitors; D010770:Phosphotransferases / Q000032:analysis; D012313:RNA / Q000096:biosynthesis* / Q000302:isolation & purification; D012335:RNA, Ribosomal / Q000032:analysis; D012343:RNA, Transfer / Q000032:analysis; D051381:Rats; D013997:Time Factors; D014227:Triazines / Q000494:pharmacology*; D014529:Uridine
D002247:Carbon Isotopes; D012335:RNA, Ribosomal; D014227:Triazines; D003562:Cytidine; D009963:Orotic Acid; D012313:RNA; D012343:RNA, Transfer; D010430:Pentosyltransferases; D010770:Phosphotransferases; D002262:Carboxy-Lyases; D001374:Azacitidine; D014529:Uridine