Cordycepin inhibits induction of murine leukovirus production by 5-iodo-2'-deoxyuridine.
Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.
D000241:Adenosine / Q000494:pharmacology; D002460:Cell Line; D002512:Cephalothin / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003839:Deoxyadenosines / Q000494:pharmacology; D003857:Deoxyuridine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D017988:Gammaretrovirus / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism
D003839:Deoxyadenosines; D003609:Dactinomycin; D000242:Cyclic AMP; D012194:RNA-Directed DNA Polymerase; D000241:Adenosine; D002512:Cephalothin; D003857:Deoxyuridine