title: Induction of hepatitis B antibody in experimental animals by immunization with A-2 plaque virus.
abstract: A sero-conversion for hepatitis B antibody has resulted from immunization of patas monkeys, guinea pigs, and rabbits with the A-2 plaque virus. This agent was isolated in tissue culture from patient sera that were positive for hepatitis B antigen. The immune response was assayed with techniques of direct and indirect counter-immunoelectrophoresis, and immune electron microscopy.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000302:isolation & purification*; D000917:Antibody Formation; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D006168:Guinea Pigs; D000882:Haplorhini; D006506:Hepatitis A / Q000097:blood; D006511:Hepatitis B Antigens / Q000032:analysis; D006507:Hepatovirus / Q000254:growth & development / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007106:Immune Sera; D007114:Immunization; D007457:Iodine Radioisotopes; D007668:Kidney; D008854:Microscopy, Electron; D010772:Phosphotungstic Acid; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay; D013194:Staining and Labeling; D014776:Virus Cultivation
chemical_list: D000914:Antibodies, Viral; D006511:Hepatitis B Antigens; D007106:Immune Sera; D007457:Iodine Radioisotopes; D010772:Phosphotungstic Acid