Stability of penicillinase plasmids in Staphylococcus aureus.
The isolation of mutants of Staphylococcus aureus that are affected in the stability of penicillinase plasmids is described. One mutation is plasmid borne and results in nonreplication of the plasmid at 42 C. A second type of mutation is host-borne and gives rise to instability of both mcr(I) and mcr(II) penicillinase plasmids but not a tetracycline-resistant plasmid.
D002876:Chromosomes, Bacterial; D003090:Coliphages; D003470:Culture Media; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial; D005796:Genes; D005816:Genetic Complementation Test; D005827:Genetics, Microbial; D006358:Hot Temperature; D009153:Mutagens; D009154:Mutation; D010405:Penicillinase / Q000096:biosynthesis*; D013053:Spectrophotometry; D013194:Staining and Labeling; D013210:Staphylococcus / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development / Q000302:isolation & purification; D013451:Sulfonic Acids; D013752:Tetracycline / Q000494:pharmacology; D014161:Transduction, Genetic
D003470:Culture Media; D004269:DNA, Bacterial; D009153:Mutagens; D013451:Sulfonic Acids; D010405:Penicillinase; D013752:Tetracycline