Inhibition of the renin-angiotensinogen reaction by pepstatin.
Pepstatin, an N-acylated pentapeptide obtained from culture filtrates of actinomycetes and first characterized as an inhibitor of pepsin, produces inhibition of the renin-substrate reaction both in vitro and in vivo.
D000190:Actinomyces / Q000032:analysis; D000510:Alpha-Globulins / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013552:Swine; D000092502:Renin Inhibitors
D000510:Alpha-Globulins; D000804:Angiotensin II; D010455:Peptides; D000092502:Renin Inhibitors