Bleomycin, and antitumor antibiotic: improved microbiological assay and tissue distribution studies in normal mice.
A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of Escherichia coli which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33 ld(10), injected intraperitoneally.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001681:Biological Assay; D001761:Bleomycin / Q000032:analysis / Q000097:blood / Q000494:pharmacology / Q000652:urine; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D005001:Ethionine / Q000494:pharmacology; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains
D000903:Antibiotics, Antineoplastic; D001761:Bleomycin; D005001:Ethionine