title: Induction of  -aminolevulinic acid synthetase in chick embryo liver cells in cluture.
abstract: delta-Aminolevulinic acid synthetase is induced in chick embryo liver culture by the natural steroid, etiocholanolone, and by the foreign chemical, 3,5-dicarbethoxy-1,4-dihydrocollidine at the level of transcription. Alternatively, inducing chemicals such as allylisopropylacetamide and gamma-hexachloro-cyclohexane act primarily at the level of translation. Hemin (K(i) = 5 muM) inhibits the induction at the level of translation. In liver cell culture, the half-life of delta-aminolevulinic acid synthetase is 3 hr, that of mRNA about 5 hr.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis; D000081:Acetamides / Q000494:pharmacology; D000217:Acyltransferases / Q000096:biosynthesis*; D000498:Allyl Compounds / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D004790:Enzyme Induction; D005043:Etiocholanolone / Q000494:pharmacology; D006207:Half-Life; D006418:Heme / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D009963:Orotic Acid / Q000378:metabolism; D011728:Pyridones / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
chemical_list: D000081:Acetamides; D000498:Allyl Compounds; D011728:Pyridones; D012333:RNA, Messenger; D003609:Dactinomycin; D006418:Heme; D001556:Hexachlorocyclohexane; D009963:Orotic Acid; D005043:Etiocholanolone; D000217:Acyltransferases; D000624:5-Aminolevulinate Synthetase; D007930:Leucine