Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions.
We used congenic-resistant mouse strains to answer questions concerning the respective roles of genes coding for major histocompatibility and background genotypes in T (thymus-derived)-B (bone marrow-derived) lymphocyte cooperative responses to hapten-protein conjugates. These studies demonstrate conclusively that the gene or genes present in the H-2 complex control the capacity of antigen-specific T and B cells to effectively interact. These findings led us to postulate that there exists on the B-lymphocyte surface an "acceptor" molecule for the active T-cell product or for the T cell itself.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D004140:Dinitrophenols; D005796:Genes; D005838:Genotype; D006241:Haptens; D006433:Hemocyanins; D006648:Histocompatibility; D007114:Immunization; D007116:Immunization, Passive; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D005719:gamma-Globulins
D004140:Dinitrophenols; D006241:Haptens; D005719:gamma-Globulins; D006433:Hemocyanins