Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release.
Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.
D000225:Adenine / Q000378:metabolism; D000227:Adenine Nucleotides / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000378:metabolism; D000941:Antigens; D003864:Depression, Chemical; D006632:Histamine / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D010944:Plants; D013268:Stimulation, Chemical; D014316:Tritium
D000227:Adenine Nucleotides; D000941:Antigens; D014316:Tritium; D000249:Adenosine Monophosphate; D006632:Histamine; D000225:Adenine