Transplantation of mouse plasmacytoma to the hamster's cheek pouch. I. Changes in tumour size and paraprotein concentration in the serum of the host.
Mouse myeloma cells (MPC-11) secreting gamma-2-b globulin were shown to proliferate into solid tumours after transplantation into the hamster cheek pouch. The implanted tumours continued to grow during the first 2 weeks; thereafter they diminished in size and disappeared completely a month after transplantation. The specific MPC-11 gammaglobulin could be detected in the serum of the hosts within 2 days after the transplantation and the changes in its concentration roughly correlated with the tumour size. The estimated half-life of the MPC-11 gammaglobulin in the circulation of the tumour-bearing hamsters was 4-6 days. Host resistance was demonstrated in tumour-bearing hamsters by their failure to develop tumours on second challenge with MPC-11 cells.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D002610:Cheek; D006224:Cricetinae; D006207:Half-Life; D051379:Mice; D009062:Mouth Neoplasms / Q000473:pathology*; D009101:Multiple Myeloma; D009365:Neoplasm Regression, Spontaneous; D009368:Neoplasm Transplantation; D010954:Plasmacytoma / Q000097:blood / Q000276:immunology / Q000473:pathology*; D013997:Time Factors; D005719:gamma-Globulins / Q000032:analysis
D001798:Blood Proteins; D005719:gamma-Globulins