Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).
Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors; D004622:Embryo, Mammalian; D006801:Humans; D007668:Kidney; D008168:Lung; D051379:Mice; D008979:Moloney murine leukemia virus / Q000187:drug effects* / Q000201:enzymology; D011119:Polynucleotides / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D012845:Sindbis Virus / Q000187:drug effects; D014500:Uracil Nucleotides / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014753:Vinyl Compounds / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000227:Adenine Nucleotides; D011119:Polynucleotides; D018894:Reverse Transcriptase Inhibitors; D014500:Uracil Nucleotides; D014753:Vinyl Compounds; D004254:DNA Nucleotidyltransferases