title: Genetic control of drug levels and of the induction of drug-metabolizing enzymes in man: individual variability in the extent of allopurinol and nortriptyline inhibition of drug metabolism.
mesh_terms: D000328:Adult; D000493:Allopurinol / Q000494:pharmacology*; D000814:Aniline Compounds; D000818:Animals; D000983:Antipyrine / Q000097:blood*; D003069:Coffee; D003580:Cytochromes / Q000378:metabolism; D001728:Dicumarol / Q000008:administration & dosage / Q000097:blood*; D000431:Ethanol / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008433:Mathematics; D008660:Metabolism / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008875:Middle Aged; D006899:Mixed Function Oxygenases; D009019:Morphinans; D009661:Nortriptyline / Q000494:pharmacology*; D010088:Oxidoreductases; D010597:Pharmacogenetics; D010634:Phenobarbital / Q000097:blood / Q000494:pharmacology; D010653:Phenylbutazone / Q000097:blood*; D011247:Pregnancy; D051381:Rats; D012907:Smoking; D013223:Statistics as Topic; D013662:Tea; D014427:Twins; D044465:White People
chemical_list: D000814:Aniline Compounds; D003069:Coffee; D003580:Cytochromes; D009019:Morphinans; D013662:Tea; D000431:Ethanol; D000493:Allopurinol; D001728:Dicumarol; D009661:Nortriptyline; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D010653:Phenylbutazone; D000983:Antipyrine; D010634:Phenobarbital