Jaundice due to iprindole.
Twenty-one patients treated for depression with iprindole developed evidence of liver damage: 15 were jaundiced, five had bilirubinuria, and one had pruritus. These complications occurred between four and 21 days after initial exposure to the drug. All patients recovered. Light and electron microscopic findings in liver biopsies of one of these patients were those of cholestasis without inflammation.
D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D000928:Antidepressive Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000032:analysis; D001646:Bile; D001663:Bilirubin / Q000652:urine; D001706:Biopsy; D002467:Cell Nucleus; D002779:Cholestasis / Q000473:pathology; D002784:Cholesterol / Q000032:analysis; D005260:Female; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D007565:Jaundice / Q000139:chemically induced*; D008099:Liver / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011537:Pruritus / Q000139:chemically induced; D013194:Staining and Labeling
D000928:Antidepressive Agents; D007211:Indoles; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin