title: History and chemistry: modification of the actinomycin molecule.
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine; D003500:Cyclization; D004247:DNA; D003609:Dactinomycin / Q000138:chemical synthesis / Q000266:history* / Q000494:pharmacology; D006865:Hydrogenation; D006900:Hydroxylation; D006909:Hydroxyproline; D007700:Kinetics; D008956:Models, Chemical; D008968:Molecular Conformation; D009566:Nitrates; D010084:Oxidation-Reduction; D010455:Peptides; D013912:Threonine
chemical_list: D009566:Nitrates; D010455:Peptides; D003609:Dactinomycin; D013912:Threonine; D002713:Chlorine; D004247:DNA; D006909:Hydroxyproline