Hepatocarcinogenesis and the appearance of serum alpha-fetoprotein in mice treated with extracts of barley grain infected with Fusarium sporotrichioides.
Experiments demonstrated a significant association between the presence of tumours in mice and AFP positivity, while AFP negativity was usually associated with the absence of tumours. The presence of AFP in the serum of tumour-bearing mice was possibly related to treatment with F. sporotrichioides extract.
D000510:Alpha-Globulins / Q000032:analysis*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000209:etiology*; D002523:Edible Grain; D005260:Female; D005326:Fetal Proteins / Q000032:analysis*; D005670:Fusarium / Q000472:pathogenicity*; D008113:Liver Neoplasms / Q000097:blood / Q000209:etiology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts
D000510:Alpha-Globulins; D005326:Fetal Proteins; D010936:Plant Extracts