Inhibition of three nucleotide polymerases by rifamycin derivatives.
It is possible to design rifamycin derivatives which can distinguish between viral RNA-instructed DNA polymerase and other nucleotide polymerases.
D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D007700:Kinetics; D009052:Leukemia Virus, Murine / Q000201:enzymology; D008274:Magnesium; D008345:Manganese; D011119:Polynucleotides; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013698:Templates, Genetic; D013942:Thymine Nucleotides
D011119:Polynucleotides; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins; D013942:Thymine Nucleotides; D008345:Manganese; D004254:DNA Nucleotidyltransferases; D012194:RNA-Directed DNA Polymerase; D008274:Magnesium