An engineering study of the peristaltic drive of axonal flow.
By determination of the rheological flow curve of minute quantities of axoplasm drawn into a microcapillary tube connected to a high vacuum, extruded axoplasm was shown to behave as a pseudoplastic fluid with a viscosity of 10(6)-times that of water and without significant signs of time-dependent thixotropic or viscoelastic properties. A theoretical analysis of peristaltic pumping of such pseudoplastic fluids by sinusoidal surface waves was combined with experimental studies of a mechanical model designed to simulate peristaltic drive. The correlation of the respective data permitted quantitative predictions for the peristaltic mechanism of axonal flow, with speed being a function of peristaltic wave geometry and fluid properties, yielding a theoretical mean value of 0.45 mm/day, i.e., of the same order as that observed in the living nerve fiber.
D000818:Animals; D001001:Anura; D001370:Axonal Transport; D004738:Engineering; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011312:Pressure; D012212:Rheology; D012584:Sciatic Nerve; D014783:Viscosity