Studies on cellular autophagocytosis. Cyclic AMP- and dibutyryl cyclic AMP-stimulated autophagy in rat liver.
Intraperitoneal injections of either cyclic AMP or dibutyryl cyclic AMP are capable of producing a wave of autophagy in rat liver which resembles closely that stimulated by glucagon. These autophagic vacuoles are acid-phosphatase-positive and appear to arise via the envelopment of organelles by double-walled cisterna. At later times these autophagic vacuoles are usually surrounded by a single membrane. Injection of equimolar amounts of 5'-AMP failed to produce a wave of autophagy. These findings constitute preliminary evidence that glucagon-stimulated autophagy is mediated at least in part by cyclic AMP.
D000818:Animals; D002087:Butyrates / Q000008:administration & dosage / Q000494:pharmacology; D000242:Cyclic AMP / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism; D008854:Microscopy, Electron; D008928:Mitochondria; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013194:Staining and Labeling; D013997:Time Factors
D002087:Butyrates; D008112:Liver Glycogen; D012965:Sodium Chloride; D005934:Glucagon; D000242:Cyclic AMP