title: A comparative immunohistochemical study of splenic arterial hyalinosis in health and disease.
abstract: Hyaline deposits in arterioles and arteries of spleen were studied immunohistochemically. Hyaline lesions in arteriosclerotic heart disease were characterized by significant deposits of IgG, IgM, beta1C-beta 1A-globulins and beta-lipoproteins. These corresponded to histochemically stained deposits of acid mucopolysaccharides and microscopic areas of musculoelastic tissue damage in the hyaline masses. While, in young adults and a few other cases of other diseases, an occasional granular to linear deposit of IgG, IgM, beta1C-beta 1A-globulin and beta-lipoprotein was noted, no localization of IgA, rabbit antihuman fibrin and rabbit antihuman fibrinogen was seen. A variety of other histochemical staining reactions were found to be negative. These findings suggest that: a) hyaline deposits in splenic arterioles and arteries occur with greater severity in patients with hypertensive and arteriosclerotic heart disease; b) a possible abnormality related to filtration defects in arteries and arterioles, resulting in the trapping of plasma proteins, appears likely; c) increased localization of acid mucopolysaccharides and destruction of musculoelastic tissue is not an uncommon feature in hyaline masses; d) fibrin is not a component of these deposits and e) further study of other organs is necesary to observe the composition of hyaline in arterioles and arteries.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D001609:Beta-Globulins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000032:analysis; D005337:Fibrin / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006025:Glycosaminoglycans / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D006818:Hyalin; D006973:Hypertension / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D008077:Lipoproteins, LDL / Q000032:analysis; D008875:Middle Aged; D011817:Rabbits / Q000276:immunology; D013157:Splenic Artery / Q000032:analysis / Q000276:immunology* / Q000473:pathology; D014652:Vascular Diseases / Q000276:immunology*
chemical_list: D001609:Beta-Globulins; D006025:Glycosaminoglycans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008077:Lipoproteins, LDL; D005337:Fibrin; D005340:Fibrinogen; D003165:Complement System Proteins