Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.
Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).
D000941:Antigens; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006969:Hypersensitivity, Immediate; D007073:Immunoglobulin E / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D007700:Kinetics; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D009183:Mycotoxins; D013268:Stimulation, Chemical
D000941:Antigens; D000970:Antineoplastic Agents; D009183:Mycotoxins; D007073:Immunoglobulin E; D000242:Cyclic AMP