The absence of cocaine- and 6-hydroxydopamine-induced supersensitivity to oxymetazoline in the rat anococcygeus muscle.
Neither cocaine nor 6-hydroxydopamine potentiated the responses of the anococcygeus muscl_ to oxymetazoline, suggesting that the specific supersensitivity to noradrenaline produced by these drugs is due to abolition of neuronal uptake mechanisms.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004347:Drug Interactions; D006892:Hydroxydopamines / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D014663:Nasal Decongestants / Q000494:pharmacology*; D010109:Oxymetazoline / Q000494:pharmacology; D051381:Rats
D006892:Hydroxydopamines; D007093:Imidazoles; D014663:Nasal Decongestants; D010109:Oxymetazoline; D003042:Cocaine