Group-specific antigens of RNA tumor viruses as markers for subinfectious expression of the RNA virus genome.
Antigenic markers associated with the major internal protein of RNA tumor viruses of the C-type have proven extremely useful in natural history studies of these viruses. This protein possesses species-specific antigenic determinants, and, in the case of mammalian C-type viruses, the protein possesses crossreactive determinants as well. These determinants are, thus, useful for species identification and classification of mammalian viruses. A unique distribution of antigens in embryonic tissues of several species (where tests are available) was detected, and in addition, antigen expression in tissues appears to be controlled by a dominant gene. These data have contributed greatly to the theory that RNA tumor-virus information is inherited as part of the cellular genome.
D000818:Animals; D000918:Antibody Specificity; D000941:Antigens; D000956:Antigens, Viral / Q000032:analysis; D002415:Cats; D002499:Centrifugation, Density Gradient; D002875:Chromosomes; D006224:Cricetinae; D003429:Cross Reactions; D000939:Epitopes / Q000032:analysis; D005815:Genetic Code; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007525:Isoelectric Focusing; D009052:Leukemia Virus, Murine / Q000032:analysis / Q000276:immunology; D051379:Mice; D010455:Peptides / Q000032:analysis; D012328:RNA Viruses / Q000276:immunology*; D051381:Rats; D012190:Retroviridae / Q000032:analysis / Q000276:immunology; D013045:Species Specificity; D014764:Viral Proteins / Q000032:analysis
D000941:Antigens; D000956:Antigens, Viral; D000939:Epitopes; D007106:Immune Sera; D010455:Peptides; D014764:Viral Proteins