Detergent effects on a reverse transcriptase activity and on inhibition by rifamycin derivatives.
A reverse transcriptase activity, extracted from virus-transformed cells, is activated by very low concentrations of nonionic detergents. These same detergents also significantly reduce the effectiveness of certain rifamycin derivatives as inhibitors of the polymerase activity when the detergents are present at micelle-forming concentrations.
D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003902:Detergents / Q000494:pharmacology*; D004789:Enzyme Activation; D012194:RNA-Directed DNA Polymerase; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D003902:Detergents; D018894:Reverse Transcriptase Inhibitors; D012294:Rifamycins; D012194:RNA-Directed DNA Polymerase