A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex.
Antibodies cytotoxic for only a subpopulation of C57Bl/10 lymph node and spleen cells were detected when rat antiserum against B10.D2 was exhaustively absorbed with B10.A lymphocytes. Antibodies of similar specificity were also detected in B10.A anti-B10.D2 and in B10.A anti-C57Bl/10 alloantisera. Reactions with recombinant strains of mice indicate that the cell-surface antigen(s) responsible for this specificity is determined by gene(s) in or to the left of the Ir-1 region of the major histocompatibility complex. A variety of criteria implicate B cells as the subpopulation of lymphocytes bearing this antigen. In view of these data and the recent report by others of a T-cell alloantigen determined by gene(s) in the major histocompatibility complex, it seems possible that there may be a variety of H-2-linked alloantigens expressed preferentially on subclasses of lymphocytes.
D000818:Animals; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D002860:Chromium Radioisotopes; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes; D005796:Genes; D006648:Histocompatibility; D007519:Isoantigens / Q000302:isolation & purification; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D016038:Skin Transplantation; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous
D002860:Chromium Radioisotopes; D000939:Epitopes; D007519:Isoantigens