Myelination inhibition factor: dissociation from induction of experimental allergic encephalomyelitis.
Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum."
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens; D002531:Cerebellum / Q000187:drug effects; D046508:Culture Techniques; D003711:Demyelinating Diseases / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006168:Guinea Pigs; D007106:Immune Sera / Q000494:pharmacology; D007456:Iodine Isotopes; D004676:Myelin Basic Protein; D009186:Myelin Sheath / Q000276:immunology; D009419:Nerve Tissue Proteins; D011817:Rabbits / Q000276:immunology; D013116:Spinal Cord / Q000276:immunology
D000941:Antigens; D007106:Immune Sera; D007456:Iodine Isotopes; D004676:Myelin Basic Protein; D009419:Nerve Tissue Proteins