Amino acid sequence of the encephalitogenic basic protein from human myelin.
Myelin from the central nervous system contains an unusual basic protein, which can induce experimental autoimmune encephalomyelitis. The basic protein from human brain was digested with trypsin and other enzymes and the sequence of the 170 amino acids was determined. The localization of the encephalitogenic determinants was described. Possible roles for the protein in the structure and function of myelin are discussed.
D000595:Amino Acid Sequence; D002850:Chromatography, Gel; D002854:Chromatography, Paper; D003488:Cyanogen Bromide; D004586:Electrophoresis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D000939:Epitopes; D006801:Humans; D009186:Myelin Sheath / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010434:Pepsin A; D010455:Peptides / Q000032:analysis; D013820:Thermolysin; D014357:Trypsin
D000939:Epitopes; D009419:Nerve Tissue Proteins; D010455:Peptides; D014357:Trypsin; D010434:Pepsin A; D013820:Thermolysin; D003488:Cyanogen Bromide