Identification of an antigen from normal human tissue that crossreacts with the carcinoembryonic antigen.
A glycoprotein present in normal human tissue is characterized that is neither organ- nor tumor-specific (nonspecific crossreacting antigen) and that crossreacts (by the Ouchterlony double-diffusion technique) with the carcinoembryonic antigen. This immunological relationship indicates common determinants on the molecules of both antigens. We demonstrate that the nonspecific crossreacting antigen is not a fragment of the carcinoembryonic antigen molecule.
D000818:Animals; D000941:Antigens / Q000302:isolation & purification; D000951:Antigens, Neoplasm / Q000302:isolation & purification; D002850:Chromatography, Gel; D003110:Colonic Neoplasms / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes; D006023:Glycoproteins; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008113:Liver Neoplasms / Q000276:immunology; D008168:Lung / Q000276:immunology; D009362:Neoplasm Metastasis; D009928:Organ Specificity; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000941:Antigens; D000951:Antigens, Neoplasm; D000939:Epitopes; D006023:Glycoproteins