Mobilization of gastric mucosal histamine and gastric secretion after H2-receptor blockade.
The effects of two H(2)-receptor antagonists (burimamide and metiamide) on the mobilization of gastric mucosal histamine, as shown by its urinary excretion and acid secretion following pentagastrin infusion, were studied in rats provided with Heidenhain pouches. Pentagastrin-induced secretion was completely inhibited without major Alterations in urinary excretion of histamine. These observations can easily be reconciled with the hypothesis that pentagastrin is not a direct stimulant of the parictal cell.
D000818:Animals; D001681:Biological Assay; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000652:urine; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D051381:Rats; D013440:Sulfides / Q000494:pharmacology; D013890:Thiourea / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D007093:Imidazoles; D013440:Sulfides; D006632:Histamine; D010418:Pentagastrin; D013890:Thiourea