Cross-reacting material in genetic variants of haemophilia B.
Cross-reacting factor IX material (CRM) was immunologically detected in the plasma of 38 normal individuals and 21 out of 22 haemophilia B patients using a rabbit antibody to factor IX. The same reacting material was detected in only nine of these patients using a human antibody. These results indicate that the plasma of the majority of haemophilia B patients contains a protein-lacking biological activity but having antigenic determinants in common with normal factor IX.
D000818:Animals; D000906:Antibodies; D000937:Antigen-Antibody Reactions; D001798:Blood Proteins / Q000032:analysis; D003429:Cross Reactions; D000939:Epitopes; D005164:Factor IX; D002836:Hemophilia B / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D009500:Neutralization Tests; D011817:Rabbits
D000906:Antibodies; D001798:Blood Proteins; D000939:Epitopes; D007106:Immune Sera; D005164:Factor IX