Antagonism by beta-adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline.
1. beta-Adrenoceptor blocking agents antagonized the inhibitory (antianaphylactic) effect of isoprenaline on antigen-induced histamine release in isolated, passively sensitized, human lung and actively sensitized guinea-pig lung suggesting that the effect is exerted through beta-adrenoceptors. No antagonism was obtained with the human allergic leucocyte preparation.2. The antianaphylactic effect of isoprenaline was antagonized not only by propranolol but also by the ;selective' beta-adrenoceptor blocking agents, practolol and butoxamine.3. The classification of beta-adrenoceptors is discussed. Certain similarities between antianaphylactic and lipolytic beta-adrenoceptors are noted.
D000083:Acetanilides / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D000707:Anaphylaxis; D000818:Animals; D000941:Antigens; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D006873:Hydroquinones / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors*; D007962:Leukocytes; D010627:Phenethylamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology*
D000083:Acetanilides; D000319:Adrenergic beta-Antagonists; D000596:Amino Acids; D000941:Antigens; D006873:Hydroquinones; D010627:Phenethylamines; D011437:Propylamines; D013565:Sympatholytics; D011433:Propranolol; D007545:Isoproterenol