Photodynamic inactivation with proflavine: quantitative comparison with iodo-deoxyuridine.
Photodynamic inactivation utilizing proflavine and light was quantitatively compared with the therapeutic antiviral effect of iodo-deoxyuridine in experimental herpetic keratitis in the rabbit. This rabbit model, which has been shown to be highly predictive for antiviral therapy in man, indicates that the photodynamic effect, though definite, is minimal.
D000818:Animals; D004195:Disease Models, Animal; D005415:Flavins / Q000627:therapeutic use*; D005452:Fluoresceins; D007065:Idoxuridine / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008027:Light; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects*; D013194:Staining and Labeling
D005415:Flavins; D005452:Fluoresceins; D007065:Idoxuridine