Genetics of the antibody response to dextran in mice.
The immune response to dextran having the alpha-1,3 linkage may be under the control of antibody structural genes. Mice that respond well to this antigen produce antibody restricted with respect to light chain class (lambda) and to an antigenic determinant resulting from a particular heavy and light chain interaction. The response to dextran is controlled by a locus linked to the-heavy chain locus.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000918:Antibody Specificity; D001665:Binding Sites; D003911:Dextrans / Q000494:pharmacology*; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D005796:Genes; D005815:Genetic Code; D008040:Genetic Linkage; D007106:Immune Sera; D007114:Immunization; D007125:Immunogenetics; D051379:Mice; D008815:Mice, Inbred Strains; D009194:Myeloma Proteins; D011487:Protein Conformation; D011995:Recombination, Genetic; D012756:Sheep / Q000276:immunology; D013045:Species Specificity; D013154:Spleen / Q000276:immunology
D003911:Dextrans; D000939:Epitopes; D007106:Immune Sera; D009194:Myeloma Proteins