Inhibition of poxvirus maturation by rifamycin derivatives and related compounds.
The effect of a number of rifamycin derivatives and related compounds on the reversibility of the rifampin-induced virus maturation block was studied by using BHK-21 cells infected with vaccinia virus. All of the derivatives of 3-formyl rifamycin SV maintained this block, the required concentration varying from 100 to 1,000 mug/ml. These compounds vary only in the nature of the side-chain attached to the 3C atom on the naphthohydroquinone moiety; no obvious correlation between the nature of this side-chain and antiviral activity was found. Streptovaricin complex and tolypomycin R also maintained the maturation block; tolypomycin also produced marked alterations in the appearance of the viroplasm contained in rifampin-induced inclusions and immature virus particles.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001386:Azides / Q000494:pharmacology; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D003486:Cyanides / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D003593:Cytoplasm / Q000382:microbiology; D003609:Dactinomycin / Q000494:pharmacology; D007181:Inclusion Bodies, Viral; D007668:Kidney; D008854:Microscopy, Electron; D009281:Naphthalenes / Q000494:pharmacology; D011691:Puromycin / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology*; D013194:Staining and Labeling; D013310:Streptovaricin / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects / Q000254:growth & development* / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D001386:Azides; D003486:Cyanides; D009281:Naphthalenes; D003561:Cytarabine; D013310:Streptovaricin; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D012293:Rifampin