Isolation of RNA virus from papillary tumors of the human renal pelvis.
Virus particles were detected by electron microscopy in three papillary cancers of the human renal pelvis. Similar particles were seen in cells from all three tumors in primary culture. An RNA virus was isolated from these tumors. The serum of tumor patients contains neutralizing antibodies against virus isolated from two of the tumors. Initial studies suggest that this agent is not a known human RNA virus.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D002247:Carbon Isotopes; D002295:Carcinoma, Transitional Cell / Q000382:microbiology*; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D003588:Cytopathogenic Effect, Viral; D005347:Fibroblasts; D006801:Humans; D007668:Kidney; D007680:Kidney Neoplasms / Q000382:microbiology*; D007682:Kidney Pelvis; D008297:Male; D008854:Microscopy, Electron; D009500:Neutralization Tests; D009963:Orotic Acid / Q000378:metabolism; D012328:RNA Viruses / Q000201:enzymology / Q000276:immunology / Q000302:isolation & purification* / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000302:isolation & purification; D013698:Templates, Genetic; D013737:Testis
D000914:Antibodies, Viral; D002247:Carbon Isotopes; D009963:Orotic Acid; D012194:RNA-Directed DNA Polymerase