Experimental papillary necrosis of the kidney. 3. Effects of reserpine and other pharmacologic agents on the lesion.
Reserpine is able to exert a pronounced inhibitory effect on the development of papillary necrosis following the administration of bromoethylamine hydrobromide to the rat. This inhibitory effect has been observed using light microscopy, histochemistry, indigo carmine excretion and urine output. These observations suggest that vasoconstriction may play a significant role in the pathogenesis of papillary necrosis, but the evidence for this is incomplete.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure; D001966:Bromine; D002395:Catecholamines / Q000032:analysis; D002746:Chlorpromazine / Q000494:pharmacology; D004396:Coloring Agents / Q000652:urine; D004195:Disease Models, Animal; D004298:Dopamine / Q000494:pharmacology; D005021:Ethylamines; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects; D007681:Kidney Papillary Necrosis / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control* / Q000652:urine; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008854:Microscopy, Electron; D010643:Phenoxybenzamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013194:Staining and Labeling; D013442:Sulfinpyrazone / Q000494:pharmacology
D002395:Catecholamines; D004396:Coloring Agents; D005021:Ethylamines; D010643:Phenoxybenzamine; D012110:Reserpine; D006493:Heparin; D007770:L-Lactate Dehydrogenase; D000251:Adenosine Triphosphatases; D001966:Bromine; D002746:Chlorpromazine; D013442:Sulfinpyrazone; D004298:Dopamine