Immunological tolerance in bone marrow-derived lymphocytes. 3. Tolerance induction in primed B cells by hapten conjugates of unrelated immunogenic or "nonimmunogenic" carriers.
The present studies were designed to probe the role(s) of T cells in preventing or altering tolerance induction in hapten-specific B cells. This was accomplished by using hapten conjugates of normally immunogenic heterologous carriers to selectively inhibit 2,4-dinitrophenyl (DNP)-primed B cells in adoptive transfer experiments in vivo. The data provide strong indications that one critical role of T-cell participation in humoral responses to antigens is to circumvent the development of a tolerogenic signal that, in the absence of such T-cell function, might otherwise ensue after binding of the antigenic determinants by specific precursor B lymphocytes.
D000818:Animals; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology*; D001666:Binding Sites, Antibody; D002352:Carrier Proteins; D004140:Dinitrophenols; D000939:Epitopes; D006241:Haptens; D007108:Immune Tolerance; D008212:Lymphocyte Depletion; D051379:Mice; D010047:Ovalbumin; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin
D000961:Antilymphocyte Serum; D002352:Carrier Proteins; D004140:Dinitrophenols; D000939:Epitopes; D006241:Haptens; D014373:Tuberculin; D010047:Ovalbumin