Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.
The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence and growth characteristics of the tumours make it potentially a good model system, but investigators should take into account the widespread nonspecific cellular injury induced by this carcinogen.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D001005:Anus Neoplasms / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced*; D003857:Deoxyuridine / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006834:Hydrazines / Q000633:toxicity; D007279:Injections, Subcutaneous; D007457:Iodine Radioisotopes; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008938:Mitosis; D011127:Polyps / Q000139:chemically induced; D013194:Staining and Labeling
D006834:Hydrazines; D007457:Iodine Radioisotopes; D003857:Deoxyuridine