Axotomy mimicked by localized colchicine application.
Comparable depression of synaptic transmission in the avian ciliary ganglion resulted from either section or localized colchicine treatment of the ciliary nerves. Both colchicine treatment and axotomny produced similar changes in RNA distribution in the cell bodies as well. Colchicine did not directly affect transmission, and action potential propagation along the ciliary nerves was normal. Interference with axoplasmic transport of material in both cases is postulated to signal the observed chromatolytic changes.
D000200:Action Potentials; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D001369:Axons / Q000187:drug effects*; D002645:Chickens; D002924:Ciliary Body / Q000294:innervation; D003078:Colchicine / Q000494:pharmacology*; D004558:Electric Stimulation; D005071:Evoked Potentials; D005724:Ganglia / Q000032:analysis / Q000166:cytology / Q000601:surgery; D012313:RNA / Q000032:analysis; D009435:Synaptic Transmission / Q000187:drug effects*
D012313:RNA; D003078:Colchicine