Autoimmune-like antibodies to the ligand-binding sites of myeloma proteins.
BALB/c mice were immunized with three A-myeloma proteins of BALB/c-2 or BALB/c origin (produced by plasmacytomas MOPC-315, MOPC-460, Adj. PC-22A). Noncross reacting antibodies were formed against Proteins-315 and 460, but the response to Protein-22A was marginal. Proteins-315 and 460 have anti-dinitrophenyl activity, and their reactions with the corresponding BALB/c antibodies were inhibited by dinitrophenyl ligands. It appears that antibodies can be formed in BALB/c mice against unique "idiotypic" determinants in the ligand-binding sites of some BALB/c mycloma proteins.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001323:Autoantibodies / Q000378:metabolism*; D001665:Binding Sites; D000939:Epitopes; D006041:Goats; D006241:Haptens; D007106:Immune Sera; D007074:Immunoglobulin G; D007456:Iodine Isotopes; D051379:Mice; D008815:Mice, Inbred Strains; D009194:Myeloma Proteins / Q000097:blood / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000276:immunology; D009596:Nitrophenols; D010954:Plasmacytoma / Q000276:immunology*; D011485:Protein Binding; D011863:Radioimmunoassay; D013045:Species Specificity
D001323:Autoantibodies; D000939:Epitopes; D006241:Haptens; D007106:Immune Sera; D007074:Immunoglobulin G; D007456:Iodine Isotopes; D009194:Myeloma Proteins; D009596:Nitrophenols