Idiotype expression and the inheritance of mouse antibody clones.
The inheritance of idiotypes was investigated using idiotypic antisera against two monoclonal antibodies to streptococcal carbohydrates derived from A/J mice. Each of the two idiotypes was characterized by a special frequency of expression. One of the idiotypes was expressed in more than 80% of A/J mice, the other in less than 20%. The idiotypes of both antibodies were strain specific and were transmitted to (A/J x BALB/cJ)F(1) hybrid mice. Furthermore, both idiotypes remained associated with the A/J heavy chain C region allotype in (A/J x BALB/cJ)F(1) hybrid mice. The results suggest that idiotypes are specified by allelic V genes, and that the heavy chain idiotype locus is linked to the heavy chain allotype locus.
D000483:Alleles; D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D000942:Antigens, Bacterial; D001666:Binding Sites, Antibody; D002241:Carbohydrates; D002478:Cells, Cultured; D002999:Clone Cells; D000939:Epitopes; D005787:Gene Frequency; D005815:Genetic Code; D008040:Genetic Linkage; D005838:Genotype; D006168:Guinea Pigs / Q000276:immunology; D006579:Heterozygote; D006824:Hybridization, Genetic; D007106:Immune Sera; D007125:Immunogenetics; D007128:Immunoglobulin Fragments; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013291:Streptococcus / Q000276:immunology
D000906:Antibodies; D000942:Antigens, Bacterial; D002241:Carbohydrates; D000939:Epitopes; D007106:Immune Sera; D007128:Immunoglobulin Fragments