title: Axonal transport of dopamine- -hydroxylase by human sural nerves in vitro.
abstract: Dopamine-beta-hydroxylase activity accumulated above a ligature on biopsy samples of normal human sural nerves incubated in vitro. The rate of accumulation indicated that this enzyme was transported distally at a velocity of 2 millimeters per hour. Axoplasmic transport of dopamine-beta-hydroxylase was greatly reduced in sural nerves from a few patients with peripheral neuropathies.
mesh_terms: D001370:Axonal Transport; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism*; D006801:Humans; D006984:Hypertrophy; D066298:In Vitro Techniques; D008026:Ligation; D009133:Muscular Atrophy / Q000201:enzymology; D009443:Neuritis / Q000201:enzymology; D009638:Norepinephrine / Q000096:biosynthesis; D010525:Peripheral Nerves / Q000201:enzymology*; D010523:Peripheral Nervous System Diseases / Q000201:enzymology*; D013497:Sural Nerve / Q000201:enzymology
chemical_list: D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine