Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen.
The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology*; D002471:Cell Transformation, Neoplastic; D003429:Cross Reactions; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D005256:Leukemia Virus, Feline / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000276:immunology; D012190:Retroviridae / Q000276:immunology*; D014764:Viral Proteins / Q000032:analysis
D000914:Antibodies, Viral; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D000939:Epitopes; D007106:Immune Sera; D014764:Viral Proteins