title: Immunohistochemical demonstration of IgG in Reed-Sternberg and other cells in Hodgkin's disease.
abstract: Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.
mesh_terms: D000921:Antibody-Producing Cells / Q000276:immunology*; D006651:Histocytochemistry; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007120:Immunochemistry; D007074:Immunoglobulin G / Q000032:analysis*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008854:Microscopy, Electron; D010544:Peroxidases; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013194:Staining and Labeling
chemical_list: D007074:Immunoglobulin G; D010544:Peroxidases