Myeloma proteins as tumor-specific transplantation antigens.
BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.
D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D000941:Antigens; D004140:Dinitrophenols; D000939:Epitopes; D007106:Immune Sera; D007114:Immunization; D005779:Immunodiffusion; D007070:Immunoglobulin A; D007456:Iodine Isotopes; D051379:Mice; D008815:Mice, Inbred Strains; D009101:Multiple Myeloma / Q000276:immunology; D009194:Myeloma Proteins / Q000378:metabolism*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D016038:Skin Transplantation; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000941:Antigens; D004140:Dinitrophenols; D000939:Epitopes; D007106:Immune Sera; D007070:Immunoglobulin A; D007456:Iodine Isotopes; D009194:Myeloma Proteins