Amyotrophic lateral sclerosis: effect of serum on anterior horn cells in tissue culture.
A high proportion of diluted serums of patients with amyotrophic lateral sclerosis were toxic to the anterior horn cells of the mouse in tissue culture. This is not a general cytotoxicity, since apparently only the neurons were killed. Serums from other degenerative neurological diseases were inactive.
D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D000818:Animals; D001769:Blood; D046508:Culture Techniques; D006801:Humans; D051379:Mice; D008858:Microscopy, Phase-Contrast; D009046:Motor Neurons / Q000187:drug effects*; D013194:Staining and Labeling