Effect of cromoglycate on anaphylactic histamine release from rat peritoneal mast cells.
Cromoglycate (1-30 muM) produced a concentration-dependent inhibition of anaphylactic histamine release from actively sensitized rat peritoneal mast cells but at lower concentrations (0.01-0.1 muM) occasionally produced a concentration-dependent enhancement of histamine release.
D000707:Anaphylaxis / Q000378:metabolism*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008407:Mast Cells / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D004205:Cromolyn Sodium