Glomerulonephritis with  - and  1C-globulin deposits induced in rats by mercuric chloride.
Repeated subcutaneous injections of 0.15 or 0.25 mg/100 g of body weight of HgCl(2) may induce a membranous glomerulonephritis in rats. This glomerulonephritis with subepithelial deposits is similar, by electron microscopy and immunohistochemistry, to experimental chronic glomerulonephritis caused by immune complexes and to the human membranous glomerulonephritis.
D000818:Animals; D001609:Beta-Globulins / Q000032:analysis*; D001835:Body Weight; D002712:Chlorides; D004195:Disease Models, Animal; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000150:complications / Q000276:immunology* / Q000473:pathology; D007106:Immune Sera; D007114:Immunization; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008628:Mercury / Q000008:administration & dosage; D008854:Microscopy, Electron; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005719:gamma-Globulins / Q000032:analysis*
D001609:Beta-Globulins; D002712:Chlorides; D007106:Immune Sera; D007074:Immunoglobulin G; D005719:gamma-Globulins; D008628:Mercury