The relationship between   2 -microglobulin and immunoglobulin in cultured human lymphoid cell lines.
beta(2)-microglobulin was detected on the cell surface and in the medium of human lymphoid cells established in long-term culture. The secretion of beta(2)-microglobulin was relatively uniform when different cell lines were compared, whereas IgG production varied widely. kappa- and micro-membrane antigens were modulated by specific antibody; beta(2)-microglobulin was not modulated. Anti-kappa and anti-micro antisera had no effect on the expression of membrane beta(2)-microglobulin, nor had anti-beta(2)-microglobulin antiserum any effect on the expression of kappa- and micro-membrane antigens.
D000818:Animals; D001609:Beta-Globulins / Q000096:biosynthesis*; D002247:Carbon Isotopes; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D011232:Chemical Precipitation; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007930:Leucine / Q000378:metabolism; D008221:Lymphoid Tissue; D011817:Rabbits / Q000276:immunology; D013237:Stereoisomerism
D001609:Beta-Globulins; D002247:Carbon Isotopes; D007106:Immune Sera; D007074:Immunoglobulin G; D007930:Leucine