Thymus-derived lymphocytes: humoral and cellular reactions distinguished by hydrocortisone.
Lymphocytes derived from the thymus (T cells) take part in the induction of humoral antibody and also effect cell-mediated graft-versus-host reactions. Preliminary treatment of mice with hydrocortisone caused an inhibition of T-cell function in humoral immunity, while enhancing the graft-versus-host reactivity of the same population of spleen cells. This suggests that different types of T cells participate in cellular and humoral immune reactions.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D002021:Buffers; D003090:Coliphages / Q000276:immunology; D046508:Culture Techniques; D004140:Dinitrophenols; D000939:Epitopes; D004926:Escherichia coli; D005620:Freund's Adjuvant; D006087:Graft vs Host Reaction / Q000187:drug effects; D006854:Hydrocortisone / Q000008:administration & dosage / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008851:Micropore Filters; D011817:Rabbits; D012709:Serum Albumin; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology*
D000906:Antibodies; D002021:Buffers; D004140:Dinitrophenols; D000939:Epitopes; D012709:Serum Albumin; D005620:Freund's Adjuvant; D006854:Hydrocortisone