Spicular arrangement of amyloid in renal biopsy.
A spicular arrangement of amyloid on the epithelial aspect of the glomerular basement membrane has been seen to a variable degree in silver-stained sections of renal biopsies in eight of 38 patients with amyloidosis. Electron microscopical examination revealed a spectrum of appearances of the amyloid fibrils which would account for this finding. Only two of these eight patients had amyloidosis secondary to chronic infection, a much lower proportion than in the group as a whole. The possibility of confusion with membranous nephropathy is discussed with relevance to possible modes of treatment.
D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology; D008854:Microscopy, Electron; D013194:Staining and Labeling
D000682:Amyloid