Neuronal dynamics and axonal flow: axonal peristalsis.
By time-lapse, phase-contrast cinemicrography of sensory nerve fibers of young mice, isolated with their originating spinal ganglia in nutrient solution, the postulated peristaltic surface drive of the cellulifugal propulsion of the semisolid axonal column at a rate of the order of 1 mm/day (1 mum/min) could be verified and quantitatively analyzed. The pulse waves follow each other at about 30-min intervals, regardless of whether the continuity of the axon is preserved or disrupted by degenerative fragmentation. Even when the axonal flow is obstructed, surface peristalsis continues.
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000166:cytology / Q000502:physiology*; D066298:In Vitro Techniques; D051379:Mice; D008858:Microscopy, Phase-Contrast; D009040:Motion Pictures; D010784:Photomicrography; D013997:Time Factors