Superinduction of endogenous type C virus by 5-bromodeoxyuridine from transformed mouse clones.
Certain transformed subclones of the mouse cell line BALB/3T3 release 5 to 15 times more type C virus per cell than the parent cell line after treatment with 5-bromodeoxyuridine. Virus release begins within 8 hours and exponentially increases for the first 24 to 48 hours. Superinducibility is associated with the transformed phenotype.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D017988:Gammaretrovirus / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D012328:RNA Viruses / Q000187:drug effects*; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000187:drug effects / Q000201:enzymology; D014779:Virus Replication / Q000187:drug effects*
D012194:RNA-Directed DNA Polymerase; D001973:Bromodeoxyuridine