Induction of a primary antihapten response in vivo by a graft-vs.-host reaction.
A primary anti-NIP PFC response can be elicited by a GVH reaction provided certain structural requirements of the NIP-carrier are met. NIP-coated F(1) erythrocytes and NIP-coated parental erythrocytes give rise to substantial anti-NIP PFC responses in F(1) mice after the injection of parental spleens. These conjugates do not of themselves give rise to an anti-NIP PFC response and, in fact, normally give rise to NIP-specific tolerance. In contrast the GVH reaction is not able to enhance the primary anti-NIP PFC response to immunogenic NIP-conjugates.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000941:Antigens; D002645:Chickens / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006087:Graft vs Host Reaction; D006241:Haptens; D007111:Immunity, Cellular; D007455:Iodine; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009596:Nitrophenols; D010648:Phenylacetates; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous
D000941:Antigens; D006241:Haptens; D009596:Nitrophenols; D010648:Phenylacetates; D007455:Iodine