Effect of histamine H2-receptor blockade on vagally induced gastric secretion in man.
Metiamide, an antagonist of histamine H(2) receptors, was administered intravenously to normal subjects and to patients with a peptic ulcer during vagal stimulation with a constant infusion of insulin. In normal and peptic-ulcer subjects there were reductions of 70% and 71% respectively in gastric-acid output compared with control tests on the same subjects. The decreased acid output resulted from a reduction in both volume of secretion and acid concentration. Metiamide is therefore a potent inhibitor of vagally-induced gastric acid secretion.
D000328:Adult; D001786:Blood Glucose; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000188:drug therapy; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy; D013440:Sulfides / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use; D013890:Thiourea / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D014630:Vagus Nerve / Q000502:physiology*
D001786:Blood Glucose; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D011955:Receptors, Drug; D013440:Sulfides; D013890:Thiourea