Potential bioreductive alkylating agents. 2. Antitumor effect and biochemical studies of naphthoquinone derivatives.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism; D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002417:Cattle; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004579:Electron Transport / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008931:Mitochondria, Muscle / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis; D012510:Sarcoma 180 / Q000188:drug therapy; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009285:Naphthoquinones; D012334:RNA, Neoplasm; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases