The suppressive effect of antibodies on cellular cooperation.
1) The primary and secondary anti-carrier antibody responses were markedly suppressed by the passively administered anti-carrier antibody but not by the anti-hapten antibody. 2) The primary and secondary anti-hapten antibody responses were suppressed not only by the passively administered anti-hapten antibody but also by the anti-carrier antibody. 3) Passively administered 3.5S fragments of the anti-carrier antibody selectively suppressed the anti-carrier antibody response but had no effect on the capacity of carrier-specific helper T cells to facilitate the anti-hapten antibody response. 4) Passively administered anti-carrier antibodies did not suppress the development of carrier-specific helper T cells but suppressed B memory cells specific for the haptenic group as well as the carrier determinant.
D000681:Amylases; D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D002352:Carrier Proteins; D004140:Dinitrophenols; D000939:Epitopes; D006241:Haptens; D006433:Hemocyanins; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007117:Immunization, Secondary; D007165:Immunosuppression Therapy; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D002352:Carrier Proteins; D004140:Dinitrophenols; D000939:Epitopes; D006241:Haptens; D006433:Hemocyanins; D000681:Amylases