Hydroxymethylation of the benzene ring. Microsomal hydroxymethylation of benzo(alpha)pyrene to 6-hydroxymethylbenzo(alpha)pyrene.
D000616:Aminoglutethimide / Q000494:pharmacology; D000818:Animals; D001580:Benzopyrenes; D002074:Butanones / Q000494:pharmacology; D002248:Carbon Monoxide / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004355:Drug Stability; D005260:Female; D007093:Imidazoles / Q000494:pharmacology; D000432:Methanol; D008797:Metyrapone / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D013696:Temperature; D013997:Time Factors; D014166:Transferases / Q000378:metabolism*; D014316:Tritium; D014465:Ultrasonics
D001580:Benzopyrenes; D002074:Butanones; D007093:Imidazoles; D000616:Aminoglutethimide; D014316:Tritium; D009249:NADP; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D014166:Transferases; D000432:Methanol; D008797:Metyrapone