Reverse transcriptase activity: increase in marrow cultures from leukaemic patients in relapse and remission.
An enzyme activity with the characteristics of reverse transcriptase was detected in marrow from patients with leukaemia in relapse and in firm haematological remission. The endogenous enzyme activities increased following culture, and in remission patients the enzyme activities reached levels equal to or exceeding those found in relapse.
D001853:Bone Marrow / Q000187:drug effects / Q000201:enzymology*; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004273:DNA, Neoplasm; D003609:Dactinomycin / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000201:enzymology*; D007945:Leukemia, Lymphoid / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology; D012334:RNA, Neoplasm; D012194:RNA-Directed DNA Polymerase / Q000032:analysis*; D012075:Remission, Spontaneous; D014316:Tritium
D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D014316:Tritium; D003609:Dactinomycin; D012194:RNA-Directed DNA Polymerase