Antihistamines block radiation-induced taste aversions.
When rats are treated with an antihistamine prior to being given sublethal doses of ionizing radiation, the formation of a conditioned saccharin aversion is completely inhibited. A profound aversion could be conditioned with histamine diphosphate as the aversive stimulus. The increase in histamine production after radiation exposure represents the physiological basis of radiation-induced taste aversions.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D002744:Chlorpheniramine / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release; D008094:Lithium / Q000494:pharmacology; D008297:Male; D011830:Radiation Effects; D011837:Radiation-Protective Agents; D051381:Rats; D013649:Taste / Q000528:radiation effects*
D011837:Radiation-Protective Agents; D002744:Chlorpheniramine; D006632:Histamine; D008094:Lithium