title: Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine.
abstract: 1 Pargyline treatment, 1 h before (+)-amphetamine (1 mg/kg), reduced amphetamine-stimulated motor activity. This inhibition was reversed in animals pretreated with p-chlorophenylalanine (PCPA).2 Following treatment with PCPA or 5,6-dihydroxytryptamine (5,6-DHT), amphetamine-induced locomotor activity was significantly potentiated. The increased response to amphetamine in PCPA-treated rats was reversed in animals pretreated with 5-hydroxytryptophan.3 The inhibition of amphetamine-stimulated locomotor activity by treatment with 6-hydroxydopamine was not reversed by PCPA treatment.4 Stereotypies produced by amphetamine were not found to be altered by depletion of 5-hydroxytryptamine.5 Induction of adrenal tyrosine hydroxylase activity produced by chronic amphetamine administration was significantly potentiated by PCPA, emphasizing the involvement of a 5-hydroxytryptamine inhibitory system in more than one action of amphetamine.
mesh_terms: D000311:Adrenal Glands / Q000201:enzymology; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D012701:Serotonin; D010293:Pargyline; D007490:Iproniazid; D014446:Tyrosine 3-Monooxygenase; D010134:Fenclonine; D003913:Dextroamphetamine