title: Implication of a tryptophyl residue in the active site of dihydrofolate reductase.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001665:Binding Sites; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003956:Dialysis; D004352:Drug Resistance, Microbial; D004591:Electrophoresis, Polyacrylamide Gel; D005493:Folic Acid Antagonists; D007780:Lacticaseibacillus casei / Q000201:enzymology; D008727:Methotrexate; D009249:NADP; D010084:Oxidation-Reduction; D011489:Protein Denaturation; D013056:Spectrophotometry, Ultraviolet; D013388:Succinimides / Q000494:pharmacology; D013762:Tetrahydrofolate Dehydrogenase / Q000032:analysis / Q000302:isolation & purification / Q000378:metabolism*; D014364:Tryptophan / Q000032:analysis / Q000378:metabolism*; D014508:Urea / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D005493:Folic Acid Antagonists; D013388:Succinimides; D009249:NADP; D014364:Tryptophan; D014508:Urea; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate