title: Activation of transcription of hut DNA by glutamine synthetase.
abstract: The correct transcription of the hut (histidine utilization) operon DNA of Salmonella typhimurium requires activation either by 3':5'-cyclic adenosine monophosphate and catabolite-activating protein or by nonadenylylated glutamine synthetase (EC 6.3.1.2.). Thus, glutamine synthetase plays a regulatory role distinct from its enzymatic function.
mesh_terms: D001426:Bacterial Proteins / Q000494:pharmacology; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D003090:Coliphages; D000242:Cyclic AMP / Q000494:pharmacology; D004269:DNA, Bacterial / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D005796:Genes; D005974:Glutamate-Ammonia Ligase / Q000494:pharmacology*; D006639:Histidine / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D009876:Operon; D012367:RNA, Viral / Q000096:biosynthesis / Q000378:metabolism; D012486:Salmonella typhimurium / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects*; D014161:Transduction, Genetic
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004279:DNA, Viral; D012367:RNA, Viral; D006639:Histidine; D000242:Cyclic AMP; D012321:DNA-Directed RNA Polymerases; D005974:Glutamate-Ammonia Ligase