Histamine: effect on self-stimulation.
When injected discretely into the lateral hypothalamus of rats, histamine inhibited electrical self-stimulation at the injection site without affecting self-stimulation in the contralateral lateral hypothalamus. This effect was blocked by prior treatment with antihistaminics. Histidine, the amino acid precursor of histamine, produced a similar effect after a delay of 6 to 10 minutes.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013238:Stereotaxic Techniques
D006634:Histamine H1 Antagonists; D006639:Histidine; D006632:Histamine