I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR).
Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D005796:Genes; D006087:Graft vs Host Reaction; D006648:Histocompatibility; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000166:cytology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens