A thermodynamic approach to problems of drug antagonism. Measurements of the parameters of affinity (pA2) of antihistaminics and a beta-haloalkylamine under varying experimental conditions.
D000704:Analysis of Variance; D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D004155:Diphenhydramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D010643:Phenoxybenzamine / Q000494:pharmacology; D013696:Temperature; D013816:Thermodynamics; D013997:Time Factors
D006634:Histamine H1 Antagonists; D010643:Phenoxybenzamine; D006632:Histamine; D004155:Diphenhydramine