Studies of human anti-gamma-globulin factors reacting with pepsin-digested gamma-globulins.
Many sera from normal individuals as well as patients with various disease states contain agglutinating antibodies which show specificity for antigenic determinants of gamma-globulin revealed by pepsin digestion at pH 4.1. Sera containing such agglutinating activity as well as sera negative for these agglutinators contain low molecular weight (3S-5S) components of slow gamma-mobility which inhibit these agglutination reactions. Low molecular weight inhibitors show both auto- and isospecificity, and are antigenically related to the 5S pepsin fragment of gamma-globulin. A common situation is thereby revealed in which human anti-gamma-globulin antibodies showing specificity for pepsin-digested gamma-globulins are present in serum along with low molecular weight gamma-globulin components capable of inhibition. Autoreactivity or autospecificity of such anti-gamma-globulin factors is a phenomenon shared by both normal human sera and sera from patients with various disease states.
D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic; D001172:Arthritis, Rheumatoid / Q000276:immunology; D003873:Dermatitis, Exfoliative / Q000276:immunology; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009369:Neoplasms / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000276:immunology; D013274:Stomach Neoplasms / Q000276:immunology; D005719:gamma-Globulins / Q000032:analysis
D000888:Antibodies, Anti-Idiotypic; D005719:gamma-Globulins