Neonatal tolerance induced by antibody against antigen-specific receptor.
Specific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic; D001666:Binding Sites, Antibody; D002794:Choline / Q000276:immunology; D002999:Clone Cells; D000939:Epitopes; D004912:Erythrocytes / Q000276:immunology; D006241:Haptens; D006462:Hemolytic Plaque Technique; D006736:Horses / Q000276:immunology; D007108:Immune Tolerance; D007114:Immunization; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009578:Nitrobenzenes / Q000276:immunology; D009943:Organophosphorus Compounds / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D006241:Haptens; D009578:Nitrobenzenes; D009943:Organophosphorus Compounds; D002794:Choline