title: Dihydrofolate reductase from a methotrexate-resistant Escherichia coli.
mesh_terms: D001665:Binding Sites; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D006863:Hydrogen-Ion Concentration; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014462:Ultrafiltration
chemical_list: D009243:NAD; D009249:NADP; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate