title: Recombinant influenza-A viruses as live vaccines for man. Report to the Medical Research Council's Committee on Influenza and other Respiratory Virus Vaccines.
abstract: The infection of volunteers with five hybrid influenza-A viruses is described. Four of these were produced in Great Britain by recombining an Ao virus, non-infective for man, with a wild Hong Kong like strain. The fifth was the American recombinant, X-31, derived from similar parents and widely used in the manufacture of killed vaccines. All five viruses had the haemagglutinin and neuraminidase of A2/Hong Kong/68. Two of the viruses were not attenuated and induced symptoms of clinical influenza. The other three were appreciably attenuated and were infective and antigenic. It seems that recombination is a rapid and effective way of producing live vaccine viruses to specification. It is also the quickest known method of attenuation.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000302:isolation & purification; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control*; D011995:Recombination, Genetic; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated