Role of peroxide in phagocytic killing of pneumococci.
Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.
D000818:Animals; D001428:Bacterial Vaccines; D001770:Blood Bactericidal Activity; D006801:Humans; D007106:Immune Sera; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D010545:Peroxides / Q000378:metabolism; D010585:Phagocyte Bactericidal Dysfunction / Q000276:immunology; D010587:Phagocytosis; D011817:Rabbits / Q000276:immunology; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000378:metabolism
D001428:Bacterial Vaccines; D007106:Immune Sera; D010545:Peroxides