title: [Inflammatory rheumatism in immunologic deficiencies].
abstract: The authors give a general review of rheumatic manifestations associated with immunodeficiency in children with reference to 7 personal observations. The review demonstrates the high frequency of this association, the variable clinical picture in one, a few, or many joints, the prolonged, relatively mild evolution that is never deforming or ankylosing, the existence of frequent auto-immune and rheumatic manifestations in families, and the usual but variable effectiveness of gammaglobulins. The possibility of immunodeficiency should be considered in cases of mono-, oligo-, and polyarthritis. The results of humoral and cellular immunological studies demonstrated a low level of immunoglobulins, the presence of nonfunctional B cells, and the presence of T cells that were probably qualitatively modified. A physiopathological interpretation is suggested.
mesh_terms: D000293:Adolescent; D001168:Arthritis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000188:drug therapy; D007223:Infant; D008297:Male; D012216:Rheumatic Diseases / Q000150:complications; D013582:Synovial Fluid / Q000166:cytology; D013583:Synovial Membrane / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D007136:Immunoglobulins; D005719:gamma-Globulins
vernacular_title: Les rhumatismes inflammatoires au cours des déficits immunitaires