Histamine H2-receptors modulate systemic anaphylaxis: a dual cardiovascular action of histamine in calves.
Depressor changes in carotid blood pressure caused by histamine or anaphylaxis in calves, were incompletely blocked by the H(1)-receptor antagonist mepyramine. Burimamide, the selective histamine H(2)-receptor antagonist, potentiated the depressor actions of histamine and anaphylaxis. Potentiated depressor responses were inhibited by mepyramine. Observations are consistent with histamine stimulating both H(1)- and H(2)-receptors to cause respectively vasodilatation and vasoconstriction.
D000707:Anaphylaxis / Q000139:chemically induced*; D000818:Animals; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D002417:Cattle; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005029:Ethylenediamines / Q000008:administration & dosage / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D011955:Receptors, Drug; D012701:Serotonin / Q000494:pharmacology
D001593:Benzyl Compounds; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D008688:Methacholine Compounds; D011725:Pyridines; D011955:Receptors, Drug; D012701:Serotonin; D006632:Histamine