Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity.
D000409:Alanine; D000617:Aminoglycosides / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D003102:Colloids; D003630:Daunorubicin / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D004579:Electron Transport; D007700:Kinetics; D046911:Macromolecular Substances; D008931:Mitochondria, Muscle / Q000201:enzymology; D009206:Myocardium; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D009279:Naphthacenes / Q000494:pharmacology; D010743:Phospholipids; D011809:Quinones / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D014451:Ubiquinone / Q000378:metabolism
D000617:Aminoglycosides; D000903:Antibiotics, Antineoplastic; D003102:Colloids; D046911:Macromolecular Substances; D009279:Naphthacenes; D010743:Phospholipids; D011809:Quinones; D014451:Ubiquinone; D004317:Doxorubicin; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D000409:Alanine; D003630:Daunorubicin