title: Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide.
abstract: Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence of H(2)-receptors. Mepyramine or burimamide alone produced partial antagonism of histamine-induced relaxation of the cat trachea. Both inhibitors added simultaneously effectively abolished the histamine response, suggesting that both H(1)- and H(2)-receptors are active in relaxing the cat trachea.
mesh_terms: D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005029:Ethylenediamines / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008688:Methacholine Compounds / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011955:Receptors, Drug / Q000187:drug effects*; D012756:Sheep; D013890:Thiourea / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
chemical_list: D001593:Benzyl Compounds; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D008688:Methacholine Compounds; D011725:Pyridines; D011955:Receptors, Drug; D006632:Histamine; D011433:Propranolol; D013890:Thiourea; D007545:Isoproterenol