[Functional cytology of bovine adenohypophysis and the effects of mestranol and chlormadinone acetate].
The synthetic oestrogen mestranol, given by mouth to young bulls, appeared to stimulate chromophobe cells of the anterior lobe of the pituitary, indicating stimulation of ACTH secretion. The mass of the pituitary was also increased by administration of 5 mg mestranol daily for 130 days. This hypertrophy was prevented by a single intramuscular injection of chlormadinone acetate. The anterior epithelium of the hypophyseal cavity reacted tooestrogen administration by increased secretory activity.
D000085:Acetates; D000284:Administration, Oral; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects*; D006651:Histocytochemistry; D007273:Injections, Intramuscular; D007620:Karyometry; D008297:Male; D008656:Mestranol / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size; D010902:Pituitary Gland / Q000166:cytology / Q000187:drug effects*; D013194:Staining and Labeling
D000085:Acetates; D004338:Drug Combinations; D002715:Chlormadinone Acetate; D000324:Adrenocorticotropic Hormone; D008656:Mestranol
Die funktionell Zytologie der bovinen Adenohypophyse und ihre Beeinflussung durch Mestranol und Chlormadinonazetat