Selective blockade of beta-adrenoceptors by 1-(p-allylphenoxy)-3-isopropylamino-2 propanol hydrochloride (h 64-52) in the anaesthetized dog.
1. The beta-adrenoceptor blocking properties of 1-(p-allylphenoxy)-3-isopropylamino-2-propanol hydrochloride (H 64/52) on the cardiovascular and bronchomotor responses to isoprenaline have been determined in the anaesthetized dog.2. H 64/52 selectively blocked the isoprenaline-induced increase in heart rate, contractile force and reduction in airway pressure in the same dose range.3. H 64/52 produced a minimal blockade of vascular beta-adrenoceptors which was apparent only when the isoprenaline-induced fall in diastolic pressure was considered. No significant vascular beta-adrenoceptor blockade with H 64/52 could be shown with the femoral arterial flow or hind-limb perfusion studies.4. These results further support the hypothesis that several different beta-adrenoceptor subtypes exist in the dog. The beta-adrenoceptors subserving cardiac stimulation and bronchodilation appear to be similar and both differ from the beta-adrenoceptor subserving vasodilatation.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects; D000498:Allyl Compounds / Q000494:pharmacology; D000605:Amino Alcohols / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology; D010477:Perfusion; D010636:Phenols / Q000494:pharmacology; D011941:Receptors, Adrenergic / Q000187:drug effects*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
D000319:Adrenergic beta-Antagonists; D000498:Allyl Compounds; D000605:Amino Alcohols; D010636:Phenols; D011941:Receptors, Adrenergic; D007545:Isoproterenol