The metabolism of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene and gamma-hexachlorocyclohexane in rats.
1. After intraperitoneal administration, gamma-hexachlorocyclohexane (Gammexane) and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of gamma-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of gamma-hexachlorocyclohexane and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in gamma-hexachlorocyclohexane metabolism in rats.
D000475:Alkenes / Q000378:metabolism*; D000818:Animals; D002854:Chromatography, Paper; D003516:Cycloparaffins / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000378:metabolism*; D010636:Phenols / Q000378:metabolism*; D051381:Rats; D013431:Sulfates / Q000378:metabolism; D013438:Sulfhydryl Compounds; D014556:Urine
D000475:Alkenes; D003516:Cycloparaffins; D005965:Glucuronates; D010636:Phenols; D013431:Sulfates; D013438:Sulfhydryl Compounds; D001556:Hexachlorocyclohexane