Antagonism of inhibitory amino acid action by tubocurarine.
A comparison has been made of the antagonism by microelectrophoretically administered (+)-tubocurarine, bicuculline methochloride and strychnine of the inhibition of spinal interneurones and Renshaw cells in the cat by glycine and gamma-aminobutyric acid. The results indicate that (+)-tubocurarine would be of little use in assessing which of these amino acids was the transmitter at central inhibitory synapses.
D000596:Amino Acids / Q000037:antagonists & inhibitors*; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D004586:Electrophoresis; D018756:GABA Antagonists; D005998:Glycine / Q000037:antagonists & inhibitors; D013116:Spinal Cord / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology*
D000596:Amino Acids; D018756:GABA Antagonists; D013331:Strychnine; D005998:Glycine; D014403:Tubocurarine; D001640:Bicuculline