The presence of I-region-associated antigens on B cells in molecules distinct from immunoglobulin and H-2K and H-2D.
The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The complexes of I-anti-I-region-associated antigens were found to be distributed throughout the lymphocyte surface both at 4 degrees and 37 degrees . In about two-thirds of the lymphocytes the complexes redistributed into caps after incubation with a second ligand (an anti-mouse immunoglobulin). The I-region specificities were in molecules distinct from immunoglobulin or from the molecules coded by the H-2K and H-2D regions.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D000939:Epitopes; D005455:Fluorescent Antibody Technique; D005796:Genes; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D007519:Isoantigens / Q000032:analysis*; D008264:Macrophages / Q000276:immunology; D051379:Mice
D000888:Antibodies, Anti-Idiotypic; D000939:Epitopes; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D007519:Isoantigens