title: [Influence of cholestasis on enzymatic induction with phenobarbital and other enzymatic aspects: experimental studies on guinea pigs].
abstract: Investigations in guinea pigs to evaluate interferences between cholestasis and enzymatic induction by phenobarbital, and influences that both experimental conditions exert on the levels of gamma-glutamyl transpeptidase in microsomes and other subcellular fractions, have shown that: 1) cholestasis inhibits inductions of cytochrome P-450 from phenobarbital; 2) gamma-glutamyl transpeptidase is not an inducible enzyme in guinea pig; 3) rises or ferum gamma-glutanyl transpeptidase produced either by cholestasis or phenobarbital administration, are not related to an increased enzymatic synthesis in the various subcellular fractions of liver cell.
mesh_terms: D000818:Animals; D002779:Cholestasis / Q000201:enzymology*; D003135:Common Bile Duct / Q000601:surgery; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction; D006168:Guinea Pigs; D008026:Ligation; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology*; D005723:gamma-Glutamyltransferase / Q000097:blood / Q000378:metabolism*
chemical_list: D003577:Cytochrome P-450 Enzyme System; D005723:gamma-Glutamyltransferase; D010634:Phenobarbital
vernacular_title: Influenze della colostasi sul'induzione da fenobarbital e su altri aspetti enzimatici: osservazioni sperimentali sulla cavia