Prediction of the non-specific cardiodepressant effects of beta-adrenoceptor blocking agents in vitro and in vivo by means of the Hansch analysis.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002021:Buffers; D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D009570:Nitriles / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010647:Phenyl Ethers / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D011893:Rana esculenta; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D002021:Buffers; D009570:Nitriles; D010647:Phenyl Ethers; D011412:Propanolamines; D001285:Atropine; D006493:Heparin; D011433:Propranolol; D010424:Pentobarbital