Hydroxylation of the carcinostatic 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) by rat liver microsomes.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D002248:Carbon Monoxide / Q000494:pharmacology; D002852:Chromatography, Ion Exchange; D003510:Cyclohexanes / Q000378:metabolism; D006900:Hydroxylation; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP; D009607:Nitrosourea Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D000970:Antineoplastic Agents; D003510:Cyclohexanes; D009607:Nitrosourea Compounds; D009249:NADP; D002248:Carbon Monoxide; D010100:Oxygen; D010634:Phenobarbital