Effect of interferon on early interferon production.
Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.
D000818:Animals; D002642:Chick Embryo; D002646:Chikungunya virus / Q000276:immunology*; D003609:Dactinomycin / Q000494:pharmacology; D066298:In Vitro Techniques; D007372:Interferons / Q000096:biosynthesis* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D014776:Virus Cultivation
D012333:RNA, Messenger; D003609:Dactinomycin; D007372:Interferons