Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity.
D000135:Acid Phosphatase / Q000378:metabolism; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002374:Catalase / Q000494:pharmacology; D003579:Cytochrome Reductases / Q000378:metabolism; D005609:Free Radicals; D007501:Iron / Q000494:pharmacology; D050356:Lipid Metabolism; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D010545:Peroxides; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D005609:Free Radicals; D010545:Peroxides; D009249:NADP; D000244:Adenosine Diphosphate; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D003579:Cytochrome Reductases; D000135:Acid Phosphatase