The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.
D000818:Animals; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone; D007274:Injections, Intraperitoneal; D007737:Kynurenine / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride; D012980:Sodium Salicylate; D013375:Substance Withdrawal Syndrome; D013997:Time Factors; D014364:Tryptophan; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D009243:NAD; D007737:Kynurenine; D000431:Ethanol; D012965:Sodium Chloride; D009249:NADP; D014364:Tryptophan; D014366:Tryptophan Oxygenase; D006854:Hydrocortisone; D012980:Sodium Salicylate; D010634:Phenobarbital