Antiserum to immunoglobulin A: Inhibition of cell-mediated demyelination in tissue culture.
Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.
D000818:Animals; D046508:Culture Techniques; D003711:Demyelinating Diseases / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000517:prevention & control*; D007106:Immune Sera / Q000494:pharmacology*; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes; D011817:Rabbits; D051381:Rats; D014276:Trigeminal Nerve; D005719:gamma-Globulins
D007106:Immune Sera; D005719:gamma-Globulins