Genetic control of the antibody response to poly-L(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys in C3H--CWB tetraparental mice.
In order to further delineate the mechanisms underlying genetic unresponsiveness, tetraparental mice were constructed from immune response-1A gene high responder and low responder parental genotypes, then were immunized with poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys ((T,G)-A--L). An analysis of the total serum allotype mixture and of the antigen-binding capacity of the separated allotypes demonstrated that in the milieu of a tetraparental mouse, both high and low responder B cells could be stimulated equally to produce identical high titered anti-(T,G)-A--L responses. Furthermore, these studies show that effective stimulation could occur across a histocompatibility disparity.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D007518:Isoantibodies; D007519:Isoantigens; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009030:Mosaicism; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D007518:Isoantibodies; D007519:Isoantigens; D010455:Peptides