Post-exposure prophylaxis of murine rabies with polyinosinic-polycytidylic acid and chlorite-oxidized amylose.
Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 mug each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.
D000688:Amylose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation; D000998:Antiviral Agents / Q000627:therapeutic use*; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D009500:Neutralization Tests; D011070:Poly I-C / Q000627:therapeutic use*; D011818:Rabies / Q000517:prevention & control*
D000998:Antiviral Agents; D007369:Interferon Inducers; D000688:Amylose; D011070:Poly I-C