The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices.
Indoramin has been tested for its ability to inhibit the uptake of tritiated (-)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other alpha-blocking agents and tricycic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigators,
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001549:Benzamides / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002722:Chlorobenzenes / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D013948:Moxisylyte / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism; D010646:Phentolamine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D012702:Serotonin Antagonists; D009435:Synaptic Transmission
D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D001549:Benzamides; D002722:Chlorobenzenes; D007211:Indoles; D018377:Neurotransmitter Agents; D010880:Piperidines; D011743:Pyrimidines; D012702:Serotonin Antagonists; D012701:Serotonin; D007099:Imipramine; D013948:Moxisylyte; D002746:Chlorpromazine; D009638:Norepinephrine; D010646:Phentolamine