Norepinephrine-sensitive adenylate cyclases in rat brain: relation to behavior and tyrosine hydroxylase.
Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.
D000241:Adenosine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology; D003342:Corpus Striatum / Q000201:enzymology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000201:enzymology*; D009043:Motor Activity; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011912:Rats, Inbred ACI; D011915:Rats, Inbred BUF; D011916:Rats, Inbred F344; D013268:Stimulation, Chemical; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014702:Veratrine / Q000494:pharmacology
D014446:Tyrosine 3-Monooxygenase; D000262:Adenylyl Cyclases; D014702:Veratrine; D000241:Adenosine; D007545:Isoproterenol; D009638:Norepinephrine