Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus.
Infection of mice with the lactic dehydrogenase virus (LDV) resulted in an elevated level of gamma-globulin. Histologic examination of the spleen and lymph nodes revealed that the number of germinal centers was greatly increased. Immunization with human gamma-globulin showed that the capacity of the virus-infected animal to produce anti-human gamma-globulin was greatly enhanced and that the virus acted as an adjuvant. From these experiments it is concluded that a virus infection (LDV) can affect the immunologic response of the host to a heterologous antigen.
D000818:Animals; D000917:Antibody Formation; D006386:Hemagglutination Tests; D007122:Immunoelectrophoresis; D066298:In Vitro Techniques; D007456:Iodine Isotopes; D007770:L-Lactate Dehydrogenase; D051379:Mice; D011234:Precipitins; D012328:RNA Viruses; D014777:Virus Diseases / Q000276:immunology*; D005719:gamma-Globulins
D007456:Iodine Isotopes; D011234:Precipitins; D005719:gamma-Globulins; D007770:L-Lactate Dehydrogenase