Activity of tetracycline, doxycycline, and minocycline against methicillin-susceptible and -resistant staphylococci.
Tetracycline, doxycycline, and minocycline were evaluated for their antibacterial activity against methicillin-susceptible and -resistant isolates of Staphylococcus. At clinically achievable levels both doxycycline and minocycline were more active than tetracycline against methicillin-susceptible organisms. Tetracycline and doxycycline had no activity against methicillin-resistant staphylococci, whereas minocycline at 2 mug/ml inhibited six of 13 strains and, at 3 mug/ml, 10 of 13 strains.
D004318:Doxycycline / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology*
D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline