Potential bioreductive alkylating agents. 4. Inhibition of coenzyme Q enzyme systems by lipoidal benzoquinone and naphthoquinone derivatives.
D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D004579:Electron Transport / Q000187:drug effects; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008931:Mitochondria, Muscle / Q000201:enzymology; D009206:Myocardium / Q000166:cytology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D010169:Palmitic Acids / Q000378:metabolism; D011809:Quinones / Q000138:chemical synthesis* / Q000494:pharmacology; D012510:Sarcoma 180 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014451:Ubiquinone / Q000037:antagonists & inhibitors*
D000477:Alkylating Agents; D009285:Naphthoquinones; D010169:Palmitic Acids; D011809:Quinones; D014451:Ubiquinone; D013385:Succinate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases