title: Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002248:Carbon Monoxide / Q000494:pharmacology; D002250:Carbon Radioisotopes; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003035:Cobalt / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005449:Fluorenes / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology; D009249:NADP / Q000378:metabolism; D009336:Necrosis / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D010882:Piperonyl Butoxide / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D013997:Time Factors; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D003486:Cyanides; D005449:Fluorenes; D014316:Tritium; D000082:Acetaminophen; D003035:Cobalt; D002110:Caffeine; D009249:NADP; D008748:Methylcholanthrene; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D010882:Piperonyl Butoxide; D010634:Phenobarbital