title: Sulphur-methylene isosterism in the development of metiamide, a new histamine H2-receptor antagonist.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D005260:Female; D006632:Histamine / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000378:metabolism / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism; D011955:Receptors, Drug / Q000187:drug effects*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000378:metabolism / Q000494:pharmacology; D013890:Thiourea / Q000378:metabolism / Q000494:pharmacology*; D014599:Uterus / Q000378:metabolism
chemical_list: D006634:Histamine H1 Antagonists; D007093:Imidazoles; D011955:Receptors, Drug; D013440:Sulfides; D006632:Histamine; D013890:Thiourea