Amino acid flux and protein synthesis after exposure of rats to either Diplococcus pneumoniae or Salmonella typhimurium.
At 26 h after inoculation of rats with Diplococcus pneumoniae, the serum concentrations of 10 and 20 individual amino acids were lower than corresponding values observed in pair-fed controls. In contrast, only 2 of 20 serum amino acids were similarly decreased in rats inoculated with Salmonella typhimurium. Despite these serum differences, a greater accumulation of labeled non-metabolizable amino acids occurred in the livers of rats infected with S. typhimurium. These data suggested a greater increase in the flux of amino acids from muscle to liver in the rats infected with S. typhimurium as compared to those infected with D. pneumoniae. A similar increase in serum protein synthesis was observed in rats infected with D. pneumoniae or S. typhimurium. However, with the latter infection, a larger percentage of the amino acids appeared to be utilized as a source of energy in addition to their role as precursors of proteins.
D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D003508:Cycloheptanes / Q000378:metabolism; D003517:Cyclopentanes / Q000378:metabolism; D008099:Liver / Q000473:pathology; D009132:Muscles / Q000473:pathology; D011014:Pneumonia / Q000097:blood* / Q000382:microbiology; D051381:Rats; D012481:Salmonella Infections, Animal / Q000097:blood* / Q000382:microbiology; D012486:Salmonella typhimurium; D013296:Streptococcus pneumoniae; D014316:Tritium
D000596:Amino Acids; D001798:Blood Proteins; D002250:Carbon Radioisotopes; D003508:Cycloheptanes; D003517:Cyclopentanes; D014316:Tritium