title: The enthalpy change for the reduction of nicotinamide--adenine dinucleotide.
abstract: The heat of the reaction NAD(+)+propan-2-ol=NADH+acetone+H(+) was determined to be 42.5+/-0.6kJ/mol (10.17+/-0.15kcal/mol) from equilibrium measurements at 9-42 degrees C catalysed by yeast alcohol dehydrogenase. With the aid of thermochemical data for acetone and propan-2-ol the values of DeltaH=-29.2kJ/mol (-6.99kcal/mol) and DeltaG(0)=22.1kJ/mol (5.28kcal/mol) are derived for the reduction of NAD (NAD(+)+H(2)=NADH+H(+)). These values are consistent with analogous but less accurate data for the ethanol-acetaldehyde reaction. Thermodynamic data for the reduction of NAD and NADP are summarized.
mesh_terms: D000433:1-Propanol; D000079:Acetaldehyde; D000096:Acetone; D000429:Alcohol Oxidoreductases; D000431:Ethanol; D009243:NAD; D009249:NADP; D010084:Oxidation-Reduction; D013816:Thermodynamics
chemical_list: D009243:NAD; D000096:Acetone; D000431:Ethanol; D009249:NADP; D000433:1-Propanol; D000429:Alcohol Oxidoreductases; D000079:Acetaldehyde