Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.
1. Rabbit aorta contracting substance (RCS) and prostaglandins were released from guinea-pig isolated perfused lungs by gentle massage and also by infusion of Prosparol.2. RCS and prostaglandins were also released by infusion into the pulmonary artery of bradykinin, arachidonic and dihomo-gamma-linolenic acids or shock perfusate (containing RCS-releasing factor).3. Arachidonic and dihomo-gamma-linolenic acids caused a prolonged release of RCS and prostaglandins whereas bradykinin and shock perfusate gave a short-lasting output.4. RCS and prostaglandins, together with histamine were released when superfused chopped lung tissue was agitated.5. Challenge of sensitized guinea-pigs in vivo led to the release of an RCS-like substance into the carotid arterial blood.6. Intravenous injection of bradykinin into guinea-pigs also released an RCS-like substance.7. The release of RCS and prostaglandins was inhibited by aspirin or indomethacin in all experiments.8. RCS contracted all vascular tissues investigated and also rat stomach strip.9. The half-life of RCS was estimated as 1-2 minutes.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001011:Aorta; D001095:Arachidonic Acids / Q000494:pharmacology; D010367:Arachis; D001241:Aspirin / Q000494:pharmacology; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology; D006168:Guinea Pigs; D006207:Half-Life; D006636:Histamine Release; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D008042:Linolenic Acids / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009821:Oils; D010047:Ovalbumin / Q000494:pharmacology; D010316:Particle Size; D011453:Prostaglandins / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D014662:Vasoconstrictor Agents / Q000378:metabolism*
D001095:Arachidonic Acids; D008042:Linolenic Acids; D009821:Oils; D011453:Prostaglandins; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D010047:Ovalbumin; D001241:Aspirin; D001920:Bradykinin; D007213:Indomethacin