title: Virulence of Venezuelan equine encephalomyelitis virus subtypes for various laboratory hosts.
abstract: Mice, guinea pigs, and duck embryo cell cultures were inoculated with known subtypes of Venezuelan equine encephalomyelitis (VEE) virus and the attenuated (TC-83) strain of VEE. With the exception of TC-83, all strains were highly pathogenic for suckling mice by either intracranial or intraperitoneal routes of inoculation used. Virulence for older mice and guinea pigs provided a means to distinguish strains. In addition, virulence or lack of virulence for adult mice or guinea pigs provides a rapid method for separating epizootic subtype IB from TC-83 VEE virus isolates.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D009033:Culicidae / Q000382:microbiology; D046508:Culture Techniques; D004196:Disease Outbreaks / Q000662:veterinary; D004372:Ducks; D004666:Encephalitis Virus, Venezuelan Equine / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D004683:Encephalomyelitis, Equine / Q000382:microbiology; D006168:Guinea Pigs; D006734:Horse Diseases / Q000382:microbiology; D006736:Horses; D007274:Injections, Intraperitoneal; D007278:Injections, Spinal; D008800:Mexico; D051379:Mice; D013045:Species Specificity; D013781:Texas; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines; D014774:Virulence
chemical_list: D014765:Viral Vaccines