Action of several  -adrenoceptor blocking drugs in the pregnant sheep and foetus.
1. The effect of several beta-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a beta-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a beta-blockade in the foetus when these compounds were administered to the pregnant ewe.2. Of the beta-blocking compounds tested, only propranolol and oxprenolol produced a prolonged blockade in the foetus. The beta-blockade with propranolol was of 3 h duration in the ewe and 10 h duration in the foetus. Oxprenolol produced a beta-blockade of 3 h duration in the ewe and 8 h in the foetus.3. The beta-blocking drugs which did cross the ovine placenta were more soluble in organic solvents (ether, chloroform, corn oil and olive oil) than those which did not cross the ovine placenta.
D000080:Acetals; D000319:Adrenergic beta-Antagonists / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D000605:Amino Alcohols / Q000494:pharmacology; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007192:Indenes / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D002040:Levobunolol / Q000494:pharmacology; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D010096:Oxprenolol / Q000494:pharmacology; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology; D012756:Sheep; D012995:Solubility; D013015:Sotalol / Q000494:pharmacology; D013997:Time Factors
D000080:Acetals; D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D004983:Ethanolamines; D007192:Indenes; D010096:Oxprenolol; D011433:Propranolol; D013015:Sotalol; D002040:Levobunolol; D007545:Isoproterenol