Tritiated norepinephrine: release from brain slices by electrical stimulation.
Slices of rat brain and heart that had concentrated H(3)-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H(3)-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.
D000818:Animals; D001923:Brain Chemistry; D002118:Calcium / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004558:Electric Stimulation; D006636:Histamine Release; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011874:Radiometry; D051381:Rats; D014316:Tritium
D014316:Tritium; D010424:Pentobarbital; D011188:Potassium; D002118:Calcium; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine