Amino-acid sequence of NADP-specific glutamate dehydrogenase of neurospora crassa.
A tentative primary structure of the NADP-specific glutamate dehydrogenase [L-glutamate: NADP oxidoreductase (deaminating), EC 1.4.1.4] from Neurospora crassa has been determined. The proposed sequence contains 452 amino-acid residues in each of the identical subunits of the hexameric enzyme. Comparison of the sequence with that of the bovine liver enzyme reveals considerable homology in the amino-terminal portion of the chain, including the vicinity of the reactive lysine, with only shorter stretches of homology within the carboxyl-terminal regions. The significance of this distribution of homologous regions is discussed.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D005969:Glutamate Dehydrogenase / Q000032:analysis*; D006868:Hydrolysis; D009249:NADP; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology*; D010446:Peptide Fragments / Q000032:analysis; D010447:Peptide Hydrolases
D010446:Peptide Fragments; D009249:NADP; D005969:Glutamate Dehydrogenase; D010447:Peptide Hydrolases