Baboon virus isolate M-7 with properties similar to feline virus RD-114.
A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 virus has helper activity as demonstrated by rescue of murine sarcoma virus (MSV) from sarcoma-positive leukemia-negative human amnion cells. The host range of the rescued M-7 pseudotype of MSV, MSV (M-7), is similar to that of RD-114 virus. MSV (M-7) is also able to transform baboon cells and causes no detectable transformation of feline cells without addition of helper feline leukemia virus. Interference properties of M-7 and RD-114 virus are identical. Virus-specific neutralizing antisera, although partially cross-reacting, can distinguish MSV (M-7) from MSV (RD-114). These similarities and differences between RD-114 and M-7 viruses are best explained as type-specific differences between two viruses within the same strain.
D000650:Amnion; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D005347:Fibroblasts; D006378:Helper Viruses; D006801:Humans; D005779:Immunodiffusion; D066298:In Vitro Techniques; D007668:Kidney; D051379:Mice; D008815:Mice, Inbred Strains / Q000196:embryology; D009500:Neutralization Tests; D010215:Papio; D010920:Placenta / Q000382:microbiology; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012190:Retroviridae / Q000302:isolation & purification*; D014762:Viral Interference
D000956:Antigens, Viral; D012194:RNA-Directed DNA Polymerase