A possible mechanism for the halothane-induced inhibition of mitochondrial respiration: binding of endogenous calcium to NADH dehydrogenase.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002417:Cattle; D002614:Chelating Agents / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology*; D007700:Kinetics; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D002614:Chelating Agents; D011955:Receptors, Drug; D009247:NADH, NADPH Oxidoreductases; D002118:Calcium; D006221:Halothane