Chronic administration of chlorcyclizine and meclizine to rats: accumulation of a metabolite formed by piperazine ring cleavage.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003619:Dansyl Compounds / Q000378:metabolism; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000378:metabolism; D005260:Female; D006634:Histamine H1 Antagonists / Q000378:metabolism* / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D013058:Mass Spectrometry; D008468:Meclizine / Q000378:metabolism*; D010087:Oxides / Q000378:metabolism; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D003619:Dansyl Compounds; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D010087:Oxides; D010879:Piperazines; D008468:Meclizine