Properties of ribosomes from Streptomyces erythreus and Streptomyces griseus.
Ribosomes from an erythromycin-producing strain, Streptomyces erythreus, lacked affinity for erythromycin and were also resistant to other macrolide antibiotics (leucomycin, spiramycin, and tylosin) and to lincomycin, whereas Streptomyces griseus B(3) ribosomes were susceptible to all of these antibiotics.
D000643:Ammonium Chloride / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000494:pharmacology; D004096:Dihydrostreptomycin Sulfate / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism; D007933:Leucomycins / Q000494:pharmacology; D008034:Lincomycin / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*; D013045:Species Specificity; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013305:Streptomyces griseus / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D007933:Leucomycins; D000643:Ammonium Chloride; D014316:Tritium; D004917:Erythromycin; D011189:Potassium Chloride; D002701:Chloramphenicol; D008034:Lincomycin; D008274:Magnesium; D004096:Dihydrostreptomycin Sulfate