Some effects of burimamide on the isolated perfused pulmonary circulation of the guinea-pig.
Infusions of burimamide were found to potentiate the pressor response to histamine and abolish the depressor response to histamine in the presence of mepyramine, in the isolated perfused guinea-pig pulmonary circulation. It is concluded that the depressor response to histamine is due to stimulation of histamine H(2)-receptors in the pulmonary vessels.
D000577:Amides / Q000494:pharmacology*; D000588:Amines / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008168:Lung / Q000187:drug effects; D008297:Male; D011312:Pressure; D011652:Pulmonary Circulation / Q000187:drug effects*; D014159:Transducers
D000577:Amides; D000588:Amines; D006634:Histamine H1 Antagonists; D006632:Histamine; D007545:Isoproterenol