The synthesis and pharmacology of a novel benzodiazepine derivative, 1-methyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one(ID-540).
D000374:Aggression / Q000187:drug effects; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001534:Bemegride / Q000037:antagonists & inhibitors; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000494:pharmacology; D002415:Cats; D002749:Chlorprothixene / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004357:Drug Synergism; D004569:Electroencephalography; D004597:Electroshock; D005260:Female; D005464:Fluorobenzenes / Q000138:chemical synthesis / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009830:Olfactory Bulb / Q000502:physiology; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012640:Seizures / Q000517:prevention & control; D012688:Septum Pellucidum / Q000502:physiology; D013331:Strychnine / Q000037:antagonists & inhibitors
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D005464:Fluorobenzenes; D001534:Bemegride; D002749:Chlorprothixene; D006591:Hexobarbital; D013331:Strychnine; D003975:Diazepam; D010433:Pentylenetetrazole