title: [Pour-on method of administering chlormadinone acetate for estrus synchronization in heifers].
abstract: Experiments with chlormadinone (Bovisynchron) on 380 heifers and 60 cows showed that the drug was absorbed following pour-on application. A volume of 2 ml was rubbed into the skin of the back anterior to the sacrum, once daily for 15 days. Residual amounts were removed 24 hours after the final application by washing the hair coat with dimethyl sulphoxide solution. Insemination was performed at the same time as after oral administration. The pour-on method was particularly suitable for heifers and cows out at pasture.
mesh_terms: D000085:Acetates; D000818:Animals; D002417:Cattle; D002715:Chlormadinone Acetate / Q000008:administration & dosage* / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects; D004121:Dimethyl Sulfoxide; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects*; D005260:Female; D007315:Insemination, Artificial / Q000662:veterinary; D008161:Lumbosacral Region; D010053:Ovary / Q000187:drug effects; D010173:Palpation; D011247:Pregnancy; D012869:Skin Absorption; D013997:Time Factors
chemical_list: D000085:Acetates; D002715:Chlormadinone Acetate; D004121:Dimethyl Sulfoxide
vernacular_title: Untersuchungen zur Anwendung von Chlormadinonazetat mittels Pour-on-Applikation zur Brunstsycchronixation von Färsen