Putrescine catabolism in mammalian brain.
In contrast with putrescine (1,4-diaminobutane), which is a substrate of diamine oxidase, monoacetylputrescine is oxidatively deaminated both in vitro and in vivo by monoamine oxidase. The product of this reaction is N-acetyl-gamma-aminobutyrate. The existence of a degradative pathway in mammalian brain for putrescine is shown, which comprises acetylation of putrescine, oxidative deamination of monoacetylputrescine to N-acetyl-gamma-aminobutyrate, transformation of N-acetyl-gamma-aminobutyrate to gamma-aminobutyrate and degradation of gamma-aminobutyrate to CO(2) via the tricarboxylic acid cycle.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D002952:Citric Acid Cycle; D004586:Electrophoresis; D007267:Injections; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D011700:Putrescine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D051381:Rats; D014316:Tritium; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives
D002250:Carbon Radioisotopes; D014316:Tritium; D002245:Carbon Dioxide; D005680:gamma-Aminobutyric Acid; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase; D011700:Putrescine