title: Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.
mesh_terms: D001665:Binding Sites; D002852:Chromatography, Ion Exchange; D002942:Circular Dichroism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology*; D005492:Folic Acid; D008433:Mathematics; D008727:Methotrexate; D009249:NADP; D009905:Optical Rotatory Dispersion; D011485:Protein Binding; D011487:Protein Conformation; D013056:Spectrophotometry, Ultraviolet; D013762:Tetrahydrofolate Dehydrogenase / Q000302:isolation & purification; D014466:Ultraviolet Rays
chemical_list: D009249:NADP; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate