Metabolism of 4-(3-(dimethylamino)propyl)-3,4-dihydro-2-(1-hydroxyethyl)-3-phenyl-2H-1,4-benzothiazine (SQ 11,579) under in vitro and in vivo conditions by rats, dogs, and monkey.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D003640:Dealkylation; D004123:Dimethylamines / Q000378:metabolism; D004285:Dogs; D000431:Ethanol / Q000378:metabolism; D005965:Glucuronates / Q000096:biosynthesis; D000882:Haplorhini; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009589:Nitrogen Oxides / Q000096:biosynthesis; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D013454:Sulfoxides / Q000096:biosynthesis; D013843:Thiazines / Q000378:metabolism*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D002250:Carbon Radioisotopes; D004123:Dimethylamines; D005965:Glucuronates; D009589:Nitrogen Oxides; D013454:Sulfoxides; D013843:Thiazines; D000431:Ethanol; D009249:NADP; D011335:Proadifen; D010088:Oxidoreductases