title: The inhibition of histamine uptake and metabolism by burimamide in the guinea-pig atrium and in mouse neoplastic mast cells, in vitro.
abstract: Burimamide, an H(2)-receptor blocking agent, has been shown capable of blocking the uptake and metabolism of [(14)C]-histamine, both in the guinea-pig isolated atrium and in murine neoplastic mast cells. This occurs even at concentrations far below the dose range capable of blocking the positive chronotropic effect of histamine in the isolated atrium. In the atrium, very low concentrations of burimamide were found capable of blocking histamine metabolism.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002460:Cell Line; D002478:Cells, Cultured; D004558:Electric Stimulation; D006168:Guinea Pigs; D006325:Heart Atria / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D008407:Mast Cells / Q000032:analysis / Q000378:metabolism*; D051379:Mice; D009206:Myocardium / Q000032:analysis / Q000378:metabolism*; D013890:Thiourea / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002250:Carbon Radioisotopes; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D006632:Histamine; D013890:Thiourea