Effects of phenobarbital, 3-methylcholanthrene, and griseofulvin on the O-demethylation of griseofulvin by liver microsomes of rats and mice.
D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism; D001589:Benzphetamine / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003640:Dealkylation; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006118:Griseofulvin / Q000378:metabolism* / Q000494:pharmacology; D006900:Hydroxylation; D008099:Liver / Q000166:cytology / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000378:metabolism*; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D051381:Rats; D013268:Stimulation, Chemical
D001580:Benzopyrenes; D002250:Carbon Radioisotopes; D011506:Proteins; D001589:Benzphetamine; D006118:Griseofulvin; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital