Filamentous capsulated streptococci from the human respiratory tract. 3. Immunochemical studies of the cross-reactivity between the cell wall antigens of a filamentous streptococcus and of pneumococcus.
A cell wall-associated polysaccharide has been isolated from a noncapsulated mutant, 89R50, of the alpha-hemolytic filamentous streptococcus of provisional capsular type 89. Chemical analysis of the polysaccharide indicates that it consists of galactosamine, glucosamine, glucose, and phosphorus. Immunological cross-reactivity was observed between the streptococcal cell wall antigen and antibody to the cell wall-like capsular polysaccharide of pneumococcus. This cross-reactivity appears attributable to similarities in the teichoic acid moieties rather than in the mucopeptide moieties of the two polymers. No chemical or immunological differences were observed in the cell wall carbohydrate of the noncapsulated streptococcus, 89R50, and that of its capsulated progenitor. It is suggested that antibody to this cell wall polysaccharide might serve as a basis for grouping other filamentous strains of streptococci of diverse capsular types, the cell wall antigens of which show similar cross-reactivity with that of pneumococcus.
D000942:Antigens, Bacterial / Q000032:analysis*; D002473:Cell Wall / Q000032:analysis / Q000276:immunology; D002848:Chromatography, DEAE-Cellulose; D003429:Cross Reactions; D005688:Galactosamine / Q000032:analysis; D005944:Glucosamine / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006801:Humans; D009088:Mucoproteins / Q000032:analysis; D009154:Mutation; D010758:Phosphorus / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000032:analysis / Q000302:isolation & purification; D011233:Precipitin Tests; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013291:Streptococcus / Q000032:analysis / Q000166:cytology / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000032:analysis / Q000276:immunology*; D013682:Teichoic Acids / Q000032:analysis
D000942:Antigens, Bacterial; D009088:Mucoproteins; D011135:Polysaccharides, Bacterial; D013682:Teichoic Acids; D010758:Phosphorus; D005688:Galactosamine; D005947:Glucose; D005944:Glucosamine