Phenytoin intoxication induced by sulthiame in epileptic patients.
Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002849:Chromatography, Gas; D003975:Diazepam / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy*; D005013:Ethosuximide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity* / Q000652:urine; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism; D008297:Male; D011324:Primidone / Q000627:therapeutic use; D013843:Thiazines / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D006827:Hydantoins; D013843:Thiazines; D011324:Primidone; D005013:Ethosuximide; D003975:Diazepam