Changes in cortisol metabolism following rifampicin therapy.
A patient with Addison's disease required increased corticosteroid dosage whilst receiving rifampicin. The pharmacological half-life of cortisol was reduced, but returned to normal when rifampicin was stopped. Cortisolproduction rates in four patients with pulmonary tuberculosis rose during treatment with rifampicin, as did urinary D-glucaric-acid excretion, an index of liver microsomal-enzyme activity. The alteration of the corticosteroid requirement in the patient with Addison's disease and the elevation of the cortisol-production rates were attributed to increased cortisol catabolism following hepatic macrosomal-enzyme induction by rifampicin.
D000224:Addison Disease / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000652:urine; D000272:Adipates / Q000652:urine; D000311:Adrenal Glands / Q000187:drug effects; D000328:Adult; D003348:Cortisone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004359:Drug Therapy, Combination; D005438:Fludrocortisone / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use*; D013307:Streptomycin / Q000627:therapeutic use; D013400:Sugar Acids / Q000652:urine; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000652:urine
D000272:Adipates; D013400:Sugar Acids; D005438:Fludrocortisone; D003348:Cortisone; D007538:Isoniazid; D012293:Rifampin; D006854:Hydrocortisone; D013307:Streptomycin