Interaction of atropine-like drugs with dopamine-containing neurones in rat brain.
1. A variety of atropine-like drugs effective in the treatment of drug-induced extrapyramidal syndromes have been investigated with regard to their interaction with dopamine-containing neurones in rat brain.2. Under some conditions benztropine, trihexyphenidyl, atropine and ethopropazine significantly antagonized the chlorpromazine-induced increase in subcortical concentrations of homovanillic acid.3. Most of the atropine-like drugs investigated also decreased the turnover of dopamine in the subcortex as measured by following the disappearance of dopamine after administration of alpha-methyl-p-tyrosine.4. These findings are suggestive that an imbalance between a dopaminergic and cholinergic system might be closely linked to the pathogenesis of extra-pyramidal movement disorders.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001590:Benztropine / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D006719:Homovanillic Acid / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009966:Orphenadrine / Q000494:pharmacology; D010640:Phenothiazines / Q000494:pharmacology; D011352:Procyclidine / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014282:Trihexyphenidyl / Q000494:pharmacology
D008781:Methyltyrosines; D010640:Phenothiazines; D001590:Benztropine; D014282:Trihexyphenidyl; D001285:Atropine; D009966:Orphenadrine; D011352:Procyclidine; D002746:Chlorpromazine; D004298:Dopamine; D006719:Homovanillic Acid