Adrenal corticosteroids enhance production of type-C virus induced by 5-iodo-2'-deoxyuridine from cultured mouse fibroblasts.
Induction of RNA "tumor" viruses by 5-iodo-2'-deoxyuridine in mouse fibroblasts is stimulated 5- to 25-fold by glucogenic adrenal corticosteroids. Enhancement of virus production by the hormones is inhibited by low concentration of cordycepin, an inhibitor of poly(A) synthesis.
D000818:Animals; D002999:Clone Cells; D003839:Deoxyadenosines / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004357:Drug Synergism; D005347:Fibroblasts; D017988:Gammaretrovirus / Q000187:drug effects*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D007065:Idoxuridine / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D011239:Prednisolone / Q000494:pharmacology; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012190:Retroviridae / Q000187:drug effects / Q000201:enzymology; D013936:Thymidine / Q000096:biosynthesis; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
D003839:Deoxyadenosines; D005938:Glucocorticoids; D012739:Gonadal Steroid Hormones; D007328:Insulin; D003907:Dexamethasone; D011239:Prednisolone; D012194:RNA-Directed DNA Polymerase; D007065:Idoxuridine; D013936:Thymidine