title: Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase.
mesh_terms: D000588:Amines / Q000494:pharmacology; D000596:Amino Acids / Q000494:pharmacology; D000630:Aminopterin / Q000494:pharmacology; D001665:Binding Sites; D002474:Cell-Free System; D005492:Folic Acid / Q000378:metabolism / Q000494:pharmacology; D005493:Folic Acid Antagonists; D005796:Genes; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology; D009154:Mutation; D009249:NADP / Q000378:metabolism; D011621:Pteridines / Q000494:pharmacology; D011739:Pyrimethamine / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000588:Amines; D000596:Amino Acids; D005493:Folic Acid Antagonists; D011621:Pteridines; D011743:Pyrimidines; D009249:NADP; D005492:Folic Acid; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D000630:Aminopterin; D008727:Methotrexate; D011739:Pyrimethamine