Potentiation of oxytocin and prostaglandins-evoked responses by (+) INPEA on isolated rat uterus: its specificity and selectivity.
The effect of (+) IPNEA on various stimulant drugs was examined on isolated rat uterus. Addition of (+) IPNEA (1 times 10- minus 5 g/ml) to the organ bath, produced marked potentiation in the contractile responses of oxytocin and prostaglandins. Potentiation was less significant to 5-HT, vasopressin, angiotensin and bradykinin. (+) INPEA did not potentiate the responses of oxytocin on isolated rat mammary strip and the responses of prostaglandins on rat stomach (fundus) strip, guinea-pig tracheal chain and guinea-pig ileum. The significance of these findings has been discussed.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004357:Drug Synergism; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008321:Mammary Glands, Animal / Q000187:drug effects; D008722:Methods; D010121:Oxytocin / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D051381:Rats; D013270:Stomach / Q000187:drug effects; D014132:Trachea / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*; D014667:Vasopressins / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D014667:Vasopressins; D000804:Angiotensin II; D010121:Oxytocin; D006916:5-Hydroxytryptophan; D001920:Bradykinin