Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.
D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D002248:Carbon Monoxide / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006418:Heme / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism; D010424:Pentobarbital / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism; D051381:Rats; D012631:Secobarbital / Q000494:pharmacology*; D013997:Time Factors; D014316:Tritium
D001463:Barbiturates; D011166:Porphyrins; D014316:Tritium; D012631:Secobarbital; D000502:Allylisopropylacetamide; D006418:Heme; D008748:Methylcholanthrene; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D000623:Porphobilinogen Synthase; D010424:Pentobarbital; D010634:Phenobarbital