The differentiation pathway of T lymphocytes. Evidence for two differentiated cell types.
Two experimental models have been used to study T-cell differentiation. The first, a graft-vs.-host reaction, was induced by injecting thymocytes or cortisone-resistant thymocytes into lethally irradiated allogeneic mice. The second was tumor graft rejection in allogeneic hosts. Ultrastructural studies at various time intervals revealed two differentiated T-cell types. One of these (the "pale" cell) is probably high cytotoxic as measured in the chromium-release assay, the other (the "dark" cell) may be an "amplifier" cell, helping in the differentiation of cytotoxic cells.
D000818:Animals; D000961:Antilymphocyte Serum; D002452:Cell Count; D002454:Cell Differentiation; D003601:Cytotoxicity Tests, Immunologic; D006087:Graft vs Host Reaction; D008223:Lymphoma / Q000276:immunology / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000276:immunology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D011817:Rabbits / Q000276:immunology; D011830:Radiation Effects; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D000961:Antilymphocyte Serum