title: Tietze's disease.
abstract: The material from a case of Tietze's disease has been examined histologically. A review of the literature on the pathology of this lesion correlated with the findings from this case indicates that there is a pathological lesion in the costal cartilage in this disease. This consists of an increased vascularity and degenerative changes with patchy loss of ground substance leading to a fibrillar appearance. Cleft formation may occur with mucoid debris which may undergo calcification. Hypertrophic changes may be present at the periphery. The aetiology still remains obscure.
mesh_terms: D000328:Adult; D002356:Cartilage / Q000032:analysis / Q000098:blood supply / Q000473:pathology; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D012272:Ribs / Q000473:pathology*; D013194:Staining and Labeling; D013991:Tietze's Syndrome / Q000473:pathology*
chemical_list: D006025:Glycosaminoglycans