Effect of calcitonin on the formation, composition, and enzymatic activity of the hepatic bile in guinea pgs.
Porcine calcitonin given to guinea pigs in doses causing hypocalcaemia and hypophosphataemia decreased the bilirubin concentration and increased the activity of gamma glutamyl transpeptidase (GGTP) in the hepatic bile. Calcitonin had no effect on bile flow, its pH, electrolyte composition including calcium, or on the concentration of protein, glucose, cholesterol, nonprotein nitrogen (NPN), and bile acids. It also did not affect the activities of alanine aminotransferase (AIAT) and alkaline phosphatase (AP) in the hepatic bile. Calcitonin increased the calcium content in the liver.
D000410:Alanine Transaminase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D001639:Bicarbonates / Q000032:analysis; D001646:Bile / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D001663:Bilirubin / Q000032:analysis; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000201:enzymology; D010710:Phosphates / Q000378:metabolism; D011188:Potassium / Q000032:analysis; D013656:Taurocholic Acid / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000032:analysis
D001639:Bicarbonates; D010710:Phosphates; D013656:Taurocholic Acid; D002116:Calcitonin; D005723:gamma-Glutamyltransferase; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin; D011188:Potassium; D002118:Calcium