title: Osteomalacia after prolonged glutethimide administration.
abstract: Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.
mesh_terms: D002762:Cholecalciferol / Q000097:blood; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005984:Glutethimide / Q000009:adverse effects*; D006207:Half-Life; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000097:blood; D008099:Liver / Q000201:enzymology; D008875:Middle Aged; D009708:Nucleotidases / Q000097:blood; D010018:Osteomalacia / Q000097:blood / Q000139:chemically induced* / Q000201:enzymology / Q000652:urine; D010429:Pentoses / Q000652:urine; D014316:Tritium; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D010429:Pentoses; D014316:Tritium; D002762:Cholecalciferol; D005984:Glutethimide; D005723:gamma-Glutamyltransferase; D009708:Nucleotidases; D007931:Leucyl Aminopeptidase