Dialkyl esters of methotrexate and 3',5'-dichloromethotrexate: synthesis and interaction with aldehyde oxidase and dihydrofolate reductase.
D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D002713:Chlorine; D004952:Esters / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008727:Methotrexate / Q000378:metabolism*; D010084:Oxidation-Reduction; D011817:Rabbits; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D004952:Esters; D002713:Chlorine; D000445:Aldehyde Oxidoreductases; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate