Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes.
The rat popliteal node graft-vs.-host assay was shown to depend on the presence of parental T cells in the inoculum. Antialloantisera raised in F(1) hybrid rats against alloantibodies of one parent directed at transplantation antigens of the other parent displayed some or all of the following specific effects on parental T cells: They inhibited local GvH by purified T-cell suspensions; they blocked the capacity of GvH-reactive cells to adsorb onto fibroblast monolayers of the relevant genotype; together with complement, they killed GvH-reactive cells.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum; D001402:B-Lymphocytes / Q000276:immunology; D001666:Binding Sites, Antibody; D002478:Cells, Cultured; D003165:Complement System Proteins; D005347:Fibroblasts / Q000276:immunology; D005838:Genotype; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D007114:Immunization; D007136:Immunoglobulins; D007518:Isoantibodies; D007519:Isoantigens; D008198:Lymph Nodes / Q000276:immunology; D017710:Lymphocyte Transfusion; D011817:Rabbits / Q000276:immunology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*; D014184:Transplantation, Homologous
D000888:Antibodies, Anti-Idiotypic; D000961:Antilymphocyte Serum; D006649:Histocompatibility Antigens; D007136:Immunoglobulins; D007518:Isoantibodies; D007519:Isoantigens; D003165:Complement System Proteins