Enzymes involved in phenylalanine metabolism in the human foetus and child.
The activities of phenylalanine p-hydroxylase, tyrosine: alpha-ketoglutarate and phenylalanine: pyruvate aminotransferases, and aromatic alpha-ketoacid reductase have been measured in liver biopsies obtained from children with a series of disorders other than phenylketonuria and from human foetuses aged 8.5 to 24 weeks. The importance of such a study in relation to the management of infants with hyperphenylalaninaemia and pregnant phenylketonuric women is discussed
D002648:Child; D002675:Child, Preschool; D005260:Female; D005333:Fetus / Q000201:enzymology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007656:Ketoglutaric Acids; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D010649:Phenylalanine / Q000097:blood / Q000378:metabolism*; D010651:Phenylalanine Hydroxylase / Q000378:metabolism*; D010661:Phenylketonurias / Q000628:therapy; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy; D011773:Pyruvates; D000637:Transaminases / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000378:metabolism
D007656:Ketoglutaric Acids; D011773:Pyruvates; D010649:Phenylalanine; D010651:Phenylalanine Hydroxylase; D007658:Ketone Oxidoreductases; D000637:Transaminases; D014444:Tyrosine Transaminase