Effects of vinblastine on catecholamine-biosynthetic enzymes in heart, sympathetic ganglion and adrenal glands of rats.
1. The effect of vinblastine on the activities of dopamine-beta-hydroxylase (DBH) in heart, superior cervical ganglion and adrenal glands of rats and tyrosine hydroxylase (TH) and phenylethanolamine-N-methyl transferase (PNMT) in adrenal glands was examined.2. In the superior cervical ganglion and heart, DBH activity decreased within hours, reached a minimum in 3 to 5 days and slowly returned towards normal over the next 2 weeks.3. There was an increase in the activities of TH, DBH and PNMT in adrenal glands which was prevented by adrenal denervation.4. When the same total dose of vinblastine was administered subdivided over a period of 5 days, enzyme activities in heart, superior cervical ganglion or adrenal glands remained unchanged.
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology*; D000818:Animals; D002247:Carbon Isotopes; D002374:Catalase / Q000494:pharmacology; D002395:Catecholamines / Q000096:biosynthesis*; D003891:Desipramine / Q000494:pharmacology; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D005725:Ganglia, Autonomic / Q000187:drug effects / Q000201:enzymology*; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008780:Methyltransferases / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D009638:Norepinephrine / Q000378:metabolism; D010625:Phenylethanolamine N-Methyltransferase; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium; D014443:Tyrosine / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014747:Vinblastine / Q000494:pharmacology*
D002247:Carbon Isotopes; D002395:Catecholamines; D014316:Tritium; D014443:Tyrosine; D014747:Vinblastine; D012110:Reserpine; D002374:Catalase; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D008780:Methyltransferases; D010625:Phenylethanolamine N-Methyltransferase; D003891:Desipramine; D009638:Norepinephrine