The effect of acute and chronic methadone treatment on the in vitro N-demethylation of methadone by microsomal enzymes of male and pregnant and nonpregnant female rats.
D000818:Animals; D003640:Dealkylation; D005260:Female; D005333:Fetus; D005958:Glucosephosphates / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D009249:NADP / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
D005958:Glucosephosphates; D009249:NADP; D010089:Oxidoreductases, N-Demethylating; D008274:Magnesium; D008691:Methadone