Relative inability to induce tolerance in adult NZB and NZB-NZW F1 mice.
Immunologic tolerance to ultracentrifuged bovine gamma globulin could not be induced in 6-wk old NZB or B/W mice, but developed readily in C3H, NZW, and C57Bl mice. NZB and B/W mice, as well as Balb/c mice, failed to become tolerant to ultracentrifuged human gamma globulin. The NZB and B/W mice also showed higher antibody titers to a standard antigenic challenge. This immunologic hyperreactivity and lack of experimental tolerance may be related to the lack of self-tolerance, autoimmunity, and lymphomas that develop in these mice at a later age.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001323:Autoantibodies; D002417:Cattle; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007108:Immune Tolerance; D007456:Iodine Isotopes; D008223:Lymphoma / Q000276:immunology; D008297:Male; D051379:Mice; D013045:Species Specificity; D014461:Ultracentrifugation; D005719:gamma-Globulins
D000941:Antigens; D001323:Autoantibodies; D007456:Iodine Isotopes; D005719:gamma-Globulins