Genetic polymorphism of C'3(beta1C-globulin) in human serum.
Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C3(1), 0.21; C3(2), 0.77; C3(3), approximately 0.01; and C3(4), approximately 0.004.
D000483:Alleles; D001609:Beta-Globulins; D001797:Blood Protein Electrophoresis; D003165:Complement System Proteins; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans; D008259:Macroglobulins / Q000032:analysis; D008967:Molecular Biology; D010641:Phenotype; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000032:analysis
D001609:Beta-Globulins; D008259:Macroglobulins; D014168:Transferrin; D003165:Complement System Proteins