Metabolism of bovine immunoglobulin. I. Metabolism of bovine IgG in cattle with chronic pyogenic infections.
Isolation of IgG-slow by anion exchange chromatography is described. The turnover of IgG-I(131) has been studied in 10 cows, 5 of which were hyperimmunoglobulinemic, i. e. with serum immunoglobulin levels above 3.0gm/100 ml. These hyperimmunoglobulinemias were caused mainly by pyogenic infections. When these cows were compared with 5 normoimmunoglobulinemic cows the salient turnover data were, high fractional turnover rates, short plasma half lives, low Ev:Iv ratios and extended plasma volumes (table I). The results are discussed in relation to similar findings in other animal species and man. Possible mechanisms of the observed hypercatabolism are outlined.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism*; D002852:Chromatography, Ion Exchange; D007122:Immunoelectrophoresis; D005719:gamma-Globulins / Q000378:metabolism*
D005719:gamma-Globulins