Limited heterogeneity of gamma globulin in hypogammaglobulinemia.
When serums of 11 patients with hypogammaglobulinemia were examined by acrylamide-gel electrophoresis, combined with diffusion analysis, for the gamma chain of immunoglobulin G, the electrophoretic distribution of immunoglobulin G differed from that of normal individuals. The differences consisted of limited heterogeneity and bimodal distributions of the proteins at times. Isolated immunoglobulin G from four of the patients showed similar phenomena. The findings indicate a deficient gene population in these patients.
D000361:Agammaglobulinemia; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008297:Male; D008661:Metabolism, Inborn Errors; D008967:Molecular Biology; D010455:Peptides / Q000032:analysis*; D005719:gamma-Globulins / Q000032:analysis*
D010455:Peptides; D005719:gamma-Globulins