Antithrombin 3. Protection against death after injection of thromboplastin.
Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha(2)-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.
D000510:Alpha-Globulins / Q000494:pharmacology; D000818:Animals; D000991:Antithrombins / Q000494:pharmacology*; D001797:Blood Protein Electrophoresis; D002417:Cattle; D002642:Chick Embryo; D004589:Electrophoresis, Disc; D006168:Guinea Pigs; D006470:Hemorrhage / Q000517:prevention & control*; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008970:Molecular Weight; D013925:Thromboplastin / Q000009:adverse effects*
D000510:Alpha-Globulins; D000991:Antithrombins; D006493:Heparin; D013925:Thromboplastin