Younger age of presentation and extraosseous tumour in IgD myelomatosis.
A study of 14 personal patients and 16 others in the literature shows that (1) IgD myelomatosis often presents at a significantly younger age than other forms of myelomatosis, and (2) during life extraosseous tumour can be detected in about two-thirds of these patients.The IgD form represents 1.5% of myelomatosis and shows an increased incidence of osteolytic lesions, hypercalcaemia, and renal failure, together with heavy Bence Jones proteinuria (90% type L).Like only Bence Jones myelomatosis, the IgD form seems to behave clinically in a more vicious manner.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001536:Bence Jones Protein / Q000652:urine; D001796:Blood Protein Disorders / Q000150:complications*; D001862:Bone Resorption / Q000209:etiology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D009362:Neoplasm Metastasis; D011507:Proteinuria / Q000150:complications; D005719:gamma-Globulins / Q000032:analysis*
D005719:gamma-Globulins; D001536:Bence Jones Protein