Limited periods of gene expression in immunoglobulin-synthesizing cells.
In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.
D002051:Burkitt Lymphoma / Q000276:immunology*; D002460:Cell Line; D005815:Genetic Code; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D008938:Mitosis; D013103:Spherocytosis, Hereditary / Q000276:immunology*; D013154:Spleen / Q000473:pathology; D005719:gamma-Globulins / Q000096:biosynthesis*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins