Metabolic dependence of fast axoplasmic transport in nerve.
Fast axoplasmic transport, shown in cat sciatic nerves by a crest of labeled activity after injection of the L7 ganglion with [(3)H]-leucine or [ (3)H]-lysine, was stopped within 15 minutes after death of the animals by bleeding. If the sciatic nerves were removed from the animals and placed in a chamber supplied with oxygen at 38 degrees centigrade, fast transport was sustained. Transport was rapidly blocked in similar in vitro preparations when the nerves were kept in a nitrogen environment. Fast axoplasmic transport is closely dependent upon oxibdative metabolism.
D000818:Animals; D001370:Axonal Transport; D001369:Axons; D002415:Cats; D005727:Ganglia, Spinal; D007267:Injections; D007930:Leucine / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D010100:Oxygen; D012584:Sciatic Nerve / Q000378:metabolism*; D009435:Synaptic Transmission; D014316:Tritium
D014316:Tritium; D007930:Leucine; D008239:Lysine; D010100:Oxygen