Transformation of human lymphocytes: inhibition by homologous alpha globulin.
An alpha globulin fraction prepared from normal human plasma by column chromatography prevents homologous lymphocyte transformation and the stimulation of DNA, and also protein synthesis induced by phytohemagglutinin and specific antigens. These observations support the concept of a normal circulating immunosuppressant factor which prevents lymphoid cell proliferation.
D000510:Alpha-Globulins / Q000494:pharmacology*; D001798:Blood Proteins / Q000096:biosynthesis; D002454:Cell Differentiation; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis; D003864:Depression, Chemical; D004168:Diphtheria Toxoid / Q000494:pharmacology; D006801:Humans; D037102:Lectins / Q000037:antagonists & inhibitors*; D008214:Lymphocytes / Q000276:immunology*; D010759:Phosphorus Isotopes; D012710:Serum Albumin, Bovine / Q000037:antagonists & inhibitors*; D013745:Tetanus Toxoid / Q000494:pharmacology
D000510:Alpha-Globulins; D001798:Blood Proteins; D004168:Diphtheria Toxoid; D037102:Lectins; D010759:Phosphorus Isotopes; D013745:Tetanus Toxoid; D012710:Serum Albumin, Bovine; D004247:DNA