5-oxo-5H-benzo[e]indole, a new type of highly sarcomagenic lactone.
The title compound, which belongs to a new synthetic group of polycyclic lactones derived from isocoumarin, exhibits a remarkably high degree of carcinogenicity in situ when injected in mice. Cancer-inducing activity has also been found in similar isocoumarins, a family known to include many naturally occurring substances.
D000818:Animals; D002273:Carcinogens; D005260:Female; D007783:Lactones; D008297:Male; D051379:Mice; D011083:Polycyclic Compounds; D012513:Sarcoma, Experimental / Q000139:chemically induced*
D002273:Carcinogens; D007783:Lactones; D011083:Polycyclic Compounds