2-chain immunoglobulin A molecules: abnormal or normal intermediates in synthesis.
Immunoglobulin A (gammaA) myeloma proteins secreted by plasma-cell tumors of mice are of two types, a common four-chain molecule and a rare two-chain (3.9S) molecule. The close similarity between two-chain gammaA molecules and four-chain gammaA molecules and their polymers is demonstrated in tryptic peptide maps of isolated polypeptide chains and by precipitin reactions with rabbit antiserums to gammaA immzunoglobulins. However, a difference between these two types is distinguishable with homologous antiserums. Homologous antiserums to two-chain gammaA immunoglobulins are specific and do not cross-react with four-chain gammaA immutnoglobulins.
D000818:Animals; D002845:Chromatography; D004586:Electrophoresis; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009374:Neoplasms, Experimental / Q000276:immunology / Q000378:metabolism; D010455:Peptides / Q000032:analysis; D010954:Plasmacytoma / Q000276:immunology* / Q000378:metabolism*; D011233:Precipitin Tests; D014357:Trypsin; D005719:gamma-Globulins / Q000096:biosynthesis*
D009363:Neoplasm Proteins; D010455:Peptides; D005719:gamma-Globulins; D014357:Trypsin