Substrate specificity of Actinoplanes antibiotic peptide lactonases.
A constitutive peptide lactonase from Actinoplanes missouriensis hydrolyzed echinomycin, stendomycin, thiostrepton, vernamycin B, staphylomycin S, and etamycin. An induced lactonase hydrolyzed actinomycin but not the other peptide lactones.
D000192:Actinomycetales / Q000201:enzymology* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D003609:Dactinomycin / Q000378:metabolism; D004790:Enzyme Induction; D004950:Esterases / Q000378:metabolism*; D007783:Lactones; D008967:Molecular Biology; D014769:Virginiamycin / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007783:Lactones; D014769:Virginiamycin; D003609:Dactinomycin; D004950:Esterases