Immune responses of inbred mice to repeated low doses of antigen: relationship to histocompatibility (H-2) type.
Immunization of inbred strains of mice with repeated minute doses (0.1 to 1.0 microgram) of hapten-protein conjugates demonstrated wide differences in the magnitude of their antibody responses, which were related to the histocompatibility (H-2) type of the strains. Immunization with a single high dose (100 micrograms) of antigen failed to demonstrate these differences.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage*; D004140:Dinitrophenols; D006241:Haptens / Q000008:administration & dosage / Q000494:pharmacology*; D006648:Histocompatibility; D007114:Immunization; D007073:Immunoglobulin E; D007178:Inbreeding; D051379:Mice; D009088:Mucoproteins; D010400:Penicillin G; D012260:Ribonucleases; D005719:gamma-Globulins
D000941:Antigens; D004140:Dinitrophenols; D006241:Haptens; D009088:Mucoproteins; D005719:gamma-Globulins; D007073:Immunoglobulin E; D012260:Ribonucleases; D010400:Penicillin G