Prevention of rhesus immunization. A controlled clinical trial with a comparatively low dose of anti-D immunoglobulin.
A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 mug) in preventing rhesus immunization.In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.
D000917:Antibody Formation; D036861:Delivery, Obstetric; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005260:Female; D005331:Fetomaternal Transfusion; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010298:Parity; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D012204:Rh-Hr Blood-Group System; D005719:gamma-Globulins / Q000008:administration & dosage*
D012204:Rh-Hr Blood-Group System; D005719:gamma-Globulins