Antagonism by DDT of the effect of valinomycin on a synthetic membrane.
The potassium conductance which is induced by 10(-6) molar valinomycin in a lecithin-decane membrane is reversed by 3 x 10(-6) molar DDT. Membranes not treated with valinomycin are not affected by DDT. This blockade of potassium conductance parallels the effect of DDT on axonic conduction. Dieldrin and lindane, whose physiological actions are in some ways like those of DDT, do not affect valinomycin-induced conductance of lecithin-decane membranes.
D000473:Alkanes; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D001369:Axons / Q000502:physiology; D003634:DDT; D004026:Dieldrin; D001556:Hexachlorocyclohexane; D008567:Membranes, Artificial; D009431:Neural Conduction / Q000187:drug effects; D010539:Permeability; D010713:Phosphatidylcholines; D011188:Potassium
D000473:Alkanes; D000900:Anti-Bacterial Agents; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D001556:Hexachlorocyclohexane; D003634:DDT; D004026:Dieldrin; D011188:Potassium