Studies on rabbit lymphocytes in vitro. IX. The suppression of antiallotype-induced blast transformation in lymphocyte cultures from allotypically suppressed donors.
The number of lymphocytes transformed in vitro by antiallotype sera in cultures obtained from allotypically suppressed rabbits is significantly less than that induced in cultures from normal rabbits. There is a compensatory increase in the amount of transformation induced by antiallotype sera directed toward the unsuppressed allotype. Thus the control of allotypic expression is suppressed rabbits appears to be the same for lymphocytes and for plasma cells.
D000483:Alleles; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D002247:Carbon Isotopes; D046508:Culture Techniques; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D007106:Immune Sera; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008297:Male; D010950:Plasma Cells / Q000276:immunology*; D011511:Proteus; D011817:Rabbits; D013936:Thymidine / Q000378:metabolism; D005719:gamma-Globulins
D000941:Antigens; D002247:Carbon Isotopes; D007106:Immune Sera; D005719:gamma-Globulins; D013936:Thymidine