Cellular sites of immunologic unresponsiveness.
The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.
D000818:Animals; D000917:Antibody Formation; D001665:Binding Sites; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002417:Cattle; D004912:Erythrocytes / Q000276:immunology; D006041:Goats; D006462:Hemolytic Plaque Technique; D051379:Mice; D011817:Rabbits; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*; D005719:gamma-Globulins
D005719:gamma-Globulins