Secretory immunoglobulin A: autoantibody activity in gastric juice.
An immunoglobulin A of the secretory variety, present in the gastric juice of a patient with pernicious anemia, was shown to have specificity for intrinsic factor. This is the first demonstration in gastric juice of antibody activity restricted to secretory IgA; further, this is the first example of an exocrine (gastric) immune system producing an autoantibody specifically directed toward a product synthesized by that same exocrine organ.
D000752:Anemia, Pernicious / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies; D001327:Autoimmune Diseases; D001345:Autoradiography; D003036:Cobalt Isotopes; D005088:Exocrine Glands / Q000276:immunology; D005750:Gastric Juice / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D007437:Intrinsic Factor; D011817:Rabbits; D005719:gamma-Globulins / Q000032:analysis* / Q000378:metabolism
D001323:Autoantibodies; D003036:Cobalt Isotopes; D005719:gamma-Globulins; D007437:Intrinsic Factor