C'3 synthesis in the human fetus and lack of transplacental passage.
Allotypic differences in the third component of complement between mothers and their newborns provided evidence for synthesis of this complement component by the fetus. There was no indication that this protein traversed the placenta. The known low level of C'3 in the neonate was confirmed, and the maternal concentration was found to be significantly elevated.
D001609:Beta-Globulins / Q000032:analysis / Q000096:biosynthesis*; D001797:Blood Protein Electrophoresis; D003165:Complement System Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005333:Fetus / Q000276:immunology* / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008967:Molecular Biology; D011247:Pregnancy; D014470:Umbilical Cord / Q000098:blood supply
D001609:Beta-Globulins; D003165:Complement System Proteins