Ouabain and streptomycin: their different loci of action on saccular hair cells in goldfish.
Ouabain, when applied to the periotic spaces, that is, to the basal end of the saccular hair cells, suppressed microphonic potentials of the inner ear in goldfish. In contrast, streptomycin produced such an effect only when it was applied directly into the endolymph, that is, to the hair-bearing ends of the hair cells.
D000818:Animals; D001693:Biological Transport, Active; D003530:Cyprinidae / Q000502:physiology*; D004096:Dihydrostreptomycin Sulfate / Q000494:pharmacology; D007758:Ear, Inner / Q000502:physiology*; D005071:Evoked Potentials; D007612:Kanamycin / Q000494:pharmacology; D007761:Labyrinthine Fluids / Q000032:analysis; D010042:Ouabain / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D013307:Streptomycin / Q000494:pharmacology*
D007612:Kanamycin; D010042:Ouabain; D011189:Potassium Chloride; D004096:Dihydrostreptomycin Sulfate; D013307:Streptomycin