Histamine release by sodium chloroplatinate.
1. The chloroplatinate ion can release histamine from the tissues in various species of animals.2. This property is not shared by other complex ions with co-ordination number 6, or other complex platinum ions.3. The release of histamine may form the basis of the known disease platinosis which affects people who work in platinum refineries, and which is characterized by symptoms of an allergic nature.4. The mechanism of the liberation of histamine by chloroplatinate resembles that which occurs during anaphylactic shock.
D000707:Anaphylaxis / Q000139:chemically induced; D000818:Animals; D001237:Asphyxia / Q000517:prevention & control; D001986:Bronchial Spasm / Q000139:chemically induced; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects; D008643:Mesentery / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009784:Occupational Diseases / Q000139:chemically induced; D010984:Platinum / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D013696:Temperature
D010984:Platinum; D006632:Histamine