Interactions of the complement system with endotoxic lipopolysaccharides in immunoglobulin-deficient sera.
Bacterial lipopolysaccharides (LPS) derived from a variety of organisms effectively induced C consumption in humans, bovines, and porcines with developmental agammaglobulinemia; birds with experimental agammaglobulinemia; and humans with agammaglobulinemia syndromes. This interaction proceeded even in precolostral piglet sera which contained less than 2.5 x 10(-6) mg/ml gamma globulin, and led to generation of neutrophil chemotactic factor and anaphylatoxin in these sera. Hence, the LPS-C interaction can proceed in sera markedly deficient in immunoglobulin. The question of whether immunoglobulins can be bypassed in the LPS-C interaction, or whether they are regularly utilized in a way so efficient that their participation is masked, was considered.
D000361:Agammaglobulinemia / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D002417:Cattle; D002645:Chickens; D003168:Complement Fixation Tests; D003165:Complement System Proteins / Q000032:analysis / Q000378:metabolism*; D006460:Hemolysin Proteins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008070:Lipopolysaccharides / Q000378:metabolism*; D009500:Neutralization Tests; D011817:Rabbits; D012705:Serratia / Q000276:immunology; D012756:Sheep; D013552:Swine; D014688:Venoms / Q000302:isolation & purification; D005719:gamma-Globulins / Q000032:analysis
D006460:Hemolysin Proteins; D008070:Lipopolysaccharides; D014688:Venoms; D005719:gamma-Globulins; D003165:Complement System Proteins