Lupus nephritis: varying complement-fixing properties of immunoglobulin G antibodies to antigens of cell nuclei.
Relative complement-fixing activity of antibodies to nuclear antigens, including DNA, were determined in serums of 15 patients with, and 65 patients without, active lupus nephritis, by comparing titers obtained in two methods. High complement-fixing activity of antibody was found in the nephritis group and low activity in the others. Results with immunoglobulin G fractions were similar.
D000974:Antibodies, Antinuclear; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001323:Autoantibodies; D002467:Cell Nucleus / Q000276:immunology; D003168:Complement Fixation Tests; D004247:DNA; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D006505:Hepatitis / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D005719:gamma-Globulins
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D005719:gamma-Globulins; D004247:DNA