Rosette-forming T lymphocytes and cell-mediated immunity in malnutrition.
The frequency of rosette-forming thymus-dependent lymphocytes was reduced in the peripheral blood of malnourished infants and children. The reduced frequency parallelled the impairment of delayed hypersensitivity response to 2, 4-dinitrochlorobenzene and decreased DNA synthesis by lymphocytes challenged with phytohaemagglutinin. The abnormalities were reversed on nutritional improvement.
D000818:Animals; D001835:Body Weight; D002648:Child; D004247:DNA / Q000096:biosynthesis; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007104:Immune Adherence Reaction; D007111:Immunity, Cellular; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D009578:Nitrobenzenes / Q000494:pharmacology; D011502:Protein-Energy Malnutrition / Q000276:immunology* / Q000628:therapy; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D037102:Lectins; D009578:Nitrobenzenes; D014316:Tritium; D004247:DNA; D013936:Thymidine