Effects of dipyridamole on neurogenic and non-neurogenic dilator responses of arterial smooth muscle.
1 In the isolated, perfused parametrial artery of the guinea-pig dipyridamole (10-100 ng/ml) potentiated dilator responses to adenosine 5'-triphosphate (ATP), glyceryl trinitrate and non-cholinergic, non-adrenergic inhibitory nerve stimulation to similar extents. In contrast dilator responses to acetylcholine were generally unaffected or reduced.2 These results support previous electro-physiological evidence that in this preparation cholinergic vasodilatation is mediated by a cellular mechanism different from that involved in the response to non-cholinergic dilator nervous activation.3 The results also suggest that potentiation of a neurally-mediated inhibitory response of smooth muscle by dipyridamole does not necessarily implicate ATP as the transmitter involved in this response.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004176:Dipyridamole / Q000494:pharmacology*; D004558:Electric Stimulation; D004958:Estradiol / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology
D014667:Vasopressins; D004958:Estradiol; D004176:Dipyridamole; D005996:Nitroglycerin; D000109:Acetylcholine