A kallikrein-like substance in cat nasal secretion.
Incubation of cat nasal secretion with cat plasma releases a substance which will contract the cat isolated jejunum, a tissue specifically sensitive to bradykinin and similar peptides. The smooth muscle stimulating activity of the incubate is potentiated and prolonged 'by the addition of the kininase inhiibitor, EDTA. From the results it is concluded that the incubation of cat nasal secretion and plasma releases a kinin-like substance, and that this kinin may have a role in the secretory and vasomotor activity of the nasal mucosa.
D000818:Animals; D001920:Bradykinin; D002415:Cats; D004492:Edetic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D007610:Kallikreins / Q000302:isolation & purification*; D008722:Methods; D009130:Muscle, Smooth / Q000187:drug effects; D009297:Nasal Mucosa / Q000378:metabolism*
D004492:Edetic Acid; D007610:Kallikreins; D001920:Bradykinin