Actin-myosin interaction: inhibition of the myosin adenosine triphosphatase by actin.
In the absence of magnesium ion, the addition of actin to myosin in a 1 :4 ratio has a strong inhibitory effect on the adenosine triphosphatase activity, in contrast to the well-known activating effect of actin in the presence of magnesium ion. This finding suggests that both effects result from a conformational change in the active site of the myosin adenosine triphosphatase.
D000251:Adenosine Triphosphatases; D000818:Animals; D002614:Chelating Agents; D011232:Chemical Precipitation; D066298:In Vitro Techniques; D008274:Magnesium; D009119:Muscle Contraction; D009124:Muscle Proteins; D011817:Rabbits
D002614:Chelating Agents; D009124:Muscle Proteins; D000251:Adenosine Triphosphatases; D008274:Magnesium