Escherichia coli mutants permissive for T4 bacteriophage with deletion in e gene (phage lysozyme).
Escherichia coli mutants have been isolated that are permissive for the infection by T4 phage with deletion in the cistron for the phage lysozyme, the e gene. Some, but not all, of these mutants are simultaneously permissive for the infection by T4 phage defective in the t gene, the product of which has also been implicated in the release of progeny phages. Most of these mutants shared the following properties: temperature sensitivity in growth and cell division, increased sensitivity towards a number of unrelated antibiotics and colicins, and increased sensitivity towards anionic detergents (sodium dodecyl sulfate and sodium deoxycholate). The possible biochemical basis for these phenotypes is discussed.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002455:Cell Division; D003087:Colicins / Q000494:pharmacology; D003090:Coliphages / Q000201:enzymology* / Q000254:growth & development; D004267:DNA Viruses / Q000201:enzymology* / Q000254:growth & development; D004352:Drug Resistance, Microbial; D004492:Edetic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D005796:Genes; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D008242:Lysogeny; D009113:Muramidase / Q000096:biosynthesis* / Q000494:pharmacology; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D012260:Ribonucleases / Q000378:metabolism; D013501:Surface-Active Agents / Q000494:pharmacology; D013696:Temperature; D014316:Tritium
D000900:Anti-Bacterial Agents; D003087:Colicins; D009153:Mutagens; D009604:Nitrosoguanidines; D013501:Surface-Active Agents; D014316:Tritium; D004492:Edetic Acid; D012260:Ribonucleases; D009113:Muramidase; D005956:Glucose-6-Phosphate Isomerase