Estrogen formation by the isolated perfused rhesus monkey brain.
Perfusion of two isolated brains from immature male rhesus monkeys with [(3)H]androstenedione resulted in the identification of free and conjugated [(3)H]estrone and free [(3)H]estradiol from the perfusates. In the dissected cerebral tissues, estrogens were recovered only from the hypothalamus and limbic system. The production of estrogens from androstenedione during the 40-minute perfusions in these two experiments totaled 1.58 and 2.83 nanograms.
D000736:Androstenes / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D004958:Estradiol / Q000096:biosynthesis*; D004970:Estrone / Q000096:biosynthesis*; D000882:Haplorhini; D007031:Hypothalamus / Q000378:metabolism*; D008032:Limbic System / Q000378:metabolism*; D008251:Macaca; D008297:Male; D010477:Perfusion; D014316:Tritium
D000736:Androstenes; D014316:Tritium; D004970:Estrone; D004958:Estradiol