Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides.
D000577:Amides; D001665:Binding Sites; D001667:Binding, Competitive; D002250:Carbon Radioisotopes; D003545:Cysteine / Q000302:isolation & purification; D003854:Deoxyribonucleotides / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005461:Fluorine / Q000378:metabolism; D007461:Iodoacetates; D007700:Kinetics; D007780:Lacticaseibacillus casei / Q000201:enzymology*; D008727:Methotrexate; D008780:Methyltransferases / Q000378:metabolism*; D008956:Models, Chemical; D010446:Peptide Fragments; D011485:Protein Binding; D011489:Protein Denaturation; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013763:Tetrahydrofolates / Q000378:metabolism / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D014316:Tritium; D014357:Trypsin; D014500:Uracil Nucleotides / Q000378:metabolism*
D000577:Amides; D002250:Carbon Radioisotopes; D003854:Deoxyribonucleotides; D007461:Iodoacetates; D010446:Peptide Fragments; D013763:Tetrahydrofolates; D014500:Uracil Nucleotides; D014316:Tritium; D005461:Fluorine; D008780:Methyltransferases; D013940:Thymidylate Synthase; D014357:Trypsin; D003545:Cysteine; D008727:Methotrexate