New, third class of amyloid fibril protein.
An unusual protein AR was isolated from the amyloid fibril preparation derived from a patient with primary amyloidosis. Protein AR was unique in its antigenicity, and revealed no structural identity with any known amyloid proteins or with immunoglobulin chains or fragments. Thus a new third class of amyloid fibril proteins besides the immunoglobulin light-chain variable region fragments and the nonimmunoglobulin protein AS, has been characterized. A component antigenically related to protein AR was found in the serum of the patient.
D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000378:metabolism*; D000818:Animals; D000941:Antigens / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis; D002850:Chromatography, Gel; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011817:Rabbits / Q000276:immunology; D013154:Spleen / Q000378:metabolism*
D000682:Amyloid; D000941:Antigens; D001798:Blood Proteins; D007106:Immune Sera; D007136:Immunoglobulins