Methotrexate analogs. 2. A facile method of preparation of lipophilic derivatives of methotrexate and 3',5'-dichloromethotrexate by direct esterification.
D000818:Animals; D002713:Chlorine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D013293:Enterococcus faecalis / Q000187:drug effects; D004952:Esters; D007780:Lacticaseibacillus casei / Q000201:enzymology; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D008727:Methotrexate / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011485:Protein Binding; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
D004952:Esters; D002713:Chlorine; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate