"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.
The frequency of epileptic seizures was observed in a controlled therapeutic trial on 23 epileptic inpatients before and after treatment with vitamin D(2) or placebo in addition to anticonvulsant drugs. The number of seizures was reduced during treatment with vitamin D(2) but not with placebo. The effect was unrelated to changes in serum calcium or magnesium. The results may support the concept that epileptics should be treated prophylactically with vitamin D.
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D002648:Child; D002986:Clinical Trials as Topic; D004827:Epilepsy / Q000188:drug therapy*; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy; D005260:Female; D006801:Humans; D008274:Magnesium / Q000097:blood; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D010919:Placebos; D011324:Primidone / Q000627:therapeutic use; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use*
D000927:Anticonvulsants; D010919:Placebos; D011324:Primidone; D014807:Vitamin D; D010672:Phenytoin; D000469:Alkaline Phosphatase; D008274:Magnesium; D002118:Calcium; D010634:Phenobarbital