Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
Various species of Streptomyces possess aminoglycoside-modifying enzymes. Streptomyces kanamyceticus contains an enzyme that acetylates the 6'-amino group of kanamycin A and B, gentamicin C(1a), and neomycin. Streptomyces spectabilis produces an enzyme that acetylates the 2'-amino group of the hexose ring of gentamicin C(1a). These enzymes catalyze reactions identical to those catalyzed by enzymes found in gram-negative bacteria containing R(antibiotic resistance)-factors. The discovery of these enzymes suggests the possibility of an evolutionary relationship between the aminoglycosideinactivating enzymes (produced by resistance determinants) in bacteria containing R-factors and similar enzymes found in the actinomycetes.
D000123:Acetyltransferases / Q000378:metabolism; D000192:Actinomycetales / Q000201:enzymology* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology; D005839:Gentamicins / Q000378:metabolism; D006027:Glycosides / Q000378:metabolism; D007612:Kanamycin / Q000378:metabolism; D007711:Klebsiella pneumoniae / Q000201:enzymology; D008847:Micromonospora / Q000201:enzymology; D010770:Phosphotransferases / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000201:enzymology; D013302:Streptomyces / Q000201:enzymology; D013307:Streptomycin / Q000378:metabolism; D014166:Transferases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D006027:Glycosides; D007612:Kanamycin; D014166:Transferases; D000123:Acetyltransferases; D010770:Phosphotransferases; D013307:Streptomycin