Australia antigen and primary biliary cirrhosis.
Sera from 64 patients with primary biliary cirrhosis have been examined for Australia antigen (Au). On immunodiffusion and immunoelectrophoresis all sera were negative. Using a radioimmunoprecipitation technique 15.6% of sera contained antigen compared with an incidence of 3.1% in matched controls, a significant difference (p = 0.015). Anti-Au was found in 9.4% of patients and in 7.8% of controls. In lymphocyte transformation studies lymphocytes from one of 24 patients with primary biliary cirrhosis transformed on stimulation with an Au-rich serum.
D000914:Antibodies, Viral; D005260:Female; D006511:Hepatitis B Antigens; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008213:Lymphocyte Activation; D008875:Middle Aged; D011863:Radioimmunoassay
D000914:Antibodies, Viral; D006511:Hepatitis B Antigens