A new antitumor agent, (alphas, 4s, 5r)-alpha-amino-3-chloro-4-hydroxy-4,5-dihydro-5-isoxazoleacetic acid (NSC-176324): preliminary evaluation against L 1210 mouse leukemia in vivo.
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D001412:Bacillus subtilis / Q000187:drug effects; D002478:Cells, Cultured; D002852:Chromatography, Ion Exchange; D003461:Crystallography; D004353:Drug Evaluation, Preclinical; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use; D007555:Isoxazoles / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010080:Oxazoles / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D007555:Isoxazoles; D010080:Oxazoles; D005998:Glycine