Urinary excretion of fibrinogen-related materials, complement, and immunoglobulins in proliferative glomerulonephritis and after renal transplantation.
Using a radial immunodiffusion technique we measured the urinary concentration of material related to complement (C3), IgM, and IgG along with fibrin-fibrinogen degradation products and heterophile (sheep) haemagglutinins in 15 patients with proliferative glomerulonephritis and in 10 patients after renal transplantation. There was a significant correlation between all variables measured, and serial studies showed that with the exception of IgG-related materials potentially useful information could be obtained on the detection of rejection and the response to treatment in both conditions. The significance of these observations is discussed.
D000818:Animals; D000910:Antibodies, Heterophile / Q000652:urine; D001673:Biodegradation, Environmental; D003165:Complement System Proteins / Q000652:urine*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism / Q000652:urine*; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology / Q000652:urine*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D005779:Immunodiffusion; D007128:Immunoglobulin Fragments / Q000652:urine; D007074:Immunoglobulin G / Q000652:urine; D007075:Immunoglobulin M / Q000652:urine; D007136:Immunoglobulins / Q000652:urine*; D007213:Indomethacin / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D012756:Sheep / Q000276:immunology; D014184:Transplantation, Homologous; D014508:Urea / Q000097:blood
D000910:Antibodies, Heterophile; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D014508:Urea; D005337:Fibrin; D005340:Fibrinogen; D003165:Complement System Proteins; D007213:Indomethacin