Pyrimido(4,5-c)isoquinolines. 2. Synthesis and biological evaluation of some 6-alkyl-,6-aralkyl-, and 6-aryl-1,3-diamino-7,8,9,10-tetrahydropyrimido(4,5-c)isoquinolines as potential folate antagnoists 1.
D000818:Animals; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007780:Lacticaseibacillus casei / Q000187:drug effects / Q000201:enzymology; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D003959:Diamines; D005493:Folic Acid Antagonists; D007546:Isoquinolines; D011743:Pyrimidines