Absorption of slow-release iron and effects of ascorbic acid in normal subjects and after partial gastrectomy.
Radiolabelled tablets of slow-release iron and ferrous sulphate containing 50 mg of elemental iron were given to 28 patients, and iron absorption was studied using a whole body counter.There was no significant difference between the absorption of ferrous sulphate and that of slow-release iron in normal subjects, anaemic patients, anaemic and non-anaemic post-gastrectomy patients, or those with coeliac disease. Ascorbic acid potentiated iron absorption, especially in anaemic post-gastrectomy patients.The indications and hazards of slow release iron preparations are discussed.
D000328:Adult; D000368:Aged; D000747:Anemia, Hypochromic / Q000188:drug therapy / Q000378:metabolism; D001205:Ascorbic Acid / Q000494:pharmacology*; D001798:Blood Proteins; D002446:Celiac Disease / Q000378:metabolism; D003692:Delayed-Action Preparations; D004357:Drug Synergism; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007504:Iron Radioisotopes; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D014915:Whole-Body Counting
D001798:Blood Proteins; D003692:Delayed-Action Preparations; D007504:Iron Radioisotopes; D007501:Iron; D001205:Ascorbic Acid