Comparison of amoxicillin and ampicillin in single-dose oral treatment of males with gonococcal urethritis.
Amoxicillin in single oral doses of 2.0 g, 2.0 g plus 1.0 g probenecid, or 3.0 g was compared with ampicillin 3.5 g plus 1.0 g probenecid in the treatment of 203 males with uncomplicated acute gonococcal urethritis. Cure rates above 95% were produced by all treatments except the 2.0-g amoxicillin dose, which cured 89% of patients. Of 198 pretreatment gonococcus isolates tested by an agar dilution technique for susceptibility to penicillin G, ampicillin and amoxicillin, over 50% showed relative resistance (MIC > 0.06 mug/ml) to the antibiotics. However, amoxicillin was somewhat more active against isolates showing considerable resistance (MIC >/= 1.0 mug/ml) to penicillin G or ampicillin. Adverse effects of amoxicillin were few: two patients reported transient nausea and six noted short-lived diarrhea. No hypersensitivity reactions were observed.
D000284:Administration, Oral; D000588:Amines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000667:Ampicillin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009325:Nausea / Q000139:chemically induced; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D010400:Penicillin G / Q000494:pharmacology; D010406:Penicillins / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D011339:Probenecid / Q000627:therapeutic use
D000588:Amines; D010406:Penicillins; D000667:Ampicillin; D011339:Probenecid; D010400:Penicillin G