Production of a runting syndrome and selective  A deficiency in mice by the administration of anti-heavy chain antisera.
Conventional Swiss mice were treated from birth with intraperitoneal injections of anti-immunoglobulins in an attempt to create an experimental dysgammaglobulinemia. Mice treated with anti-gammaM were immunologically suppressed in all immunoglobulin classes as determined by serum antibody titers, splenic plaque-forming cells, serum immunoglobulin levels, and immunofluorescent analysis of plasma cells in lymphoid tissues. Treatment immediately after birth with high concentrations of anti-gammaM leads to a developmental arrest characterized by severe immunosuppression, failure to gain weight, and premature death. The pathogenesis of anti-gammaM runting syndrome is unknown. Animals similarly treated with anti-gammaG, anti-gammaA, or control normal goat or rabbit gamma-globulins developed normally. The frequency of occurrence and severity of anti-gammaM-induced runting syndrome is dependent upon the concentration of anti-gammaM-globulin administered. Administration of anti-gammaA resulted in a selective gammaA deficiency that was characterized by a marked reduction in serum-gammaA and an absence of gammaA-containing cells in the spleen. However, essentially normal numbers of plasma cells were found in the gastrointestinal lamina propria of anti-gammaA-treated animals concomitantly with suppressed levels of gammaA in intestinal fluids.
D000818:Animals; D000831:Animals, Newborn; D000917:Antibody Formation; D004912:Erythrocytes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006041:Goats / Q000276:immunology; D006086:Graft vs Host Disease / Q000209:etiology*; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000008:administration & dosage; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D007165:Immunosuppression Therapy; D007422:Intestines / Q000276:immunology; D051379:Mice; D010950:Plasma Cells / Q000276:immunology; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology
D007106:Immune Sera; D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M