Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene.
Hybridization kinetic analyses with synthetic DNA indicate that there are only two to three copies of the kappa constant region gene per haploid genome. This result lends weight to the argument that the immunoglobulin light chain is encoded by more than one continuous gene sequence.
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D004273:DNA, Neoplasm / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D005796:Genes; D005815:Genetic Code; D006238:Haploidy; D007128:Immunoglobulin Fragments / Q000096:biosynthesis*; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis*; D007700:Kinetics; D051379:Mice; D009374:Neoplasms, Experimental / Q000032:analysis; D009693:Nucleic Acid Hybridization; D010954:Plasmacytoma; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D014316:Tritium
D004273:DNA, Neoplasm; D007128:Immunoglobulin Fragments; D007145:Immunoglobulin kappa-Chains; D012333:RNA, Messenger; D014316:Tritium