Effect of biogenic amines and cannabinoids on bacterial chemotaxis.
The chemotactic response of Pseudomonas fluorescens was significantly enhanced by the stimulants dl-amphetamine and epinephrine. Acetylcholine, a physiological antagonist of epinephrine, and the cannabinoid tetrahydrocannabinol inhibited bacterial chemotaxis. It may be possible to use bacterial chemotaxis as a bioassay in biochemical studies of drug action.
D000109:Acetylcholine / Q000494:pharmacology; D000661:Amphetamine / Q000494:pharmacology; D001679:Biogenic Amines / Q000494:pharmacology*; D001681:Biological Assay; D002188:Cannabis; D002633:Chemotaxis / Q000187:drug effects*; D003470:Culture Media; D013759:Dronabinol / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D007930:Leucine; D008858:Microscopy, Phase-Contrast; D011549:Pseudomonas; D011551:Pseudomonas fluorescens / Q000187:drug effects; D013237:Stereoisomerism
D001679:Biogenic Amines; D003470:Culture Media; D013759:Dronabinol; D000661:Amphetamine; D007930:Leucine; D000109:Acetylcholine; D004837:Epinephrine