Methotrexate analogs. 3. Synthesis and biological properties of some side-chain altered analogs.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000627:therapeutic use; D002645:Chickens; D013293:Enterococcus faecalis / Q000187:drug effects / Q000254:growth & development; D005493:Folic Acid Antagonists; D007780:Lacticaseibacillus casei / Q000187:drug effects / Q000201:enzymology; D007939:Leukemia L1210 / Q000188:drug therapy / Q000201:enzymology; D007942:Leukemia, Experimental / Q000188:drug therapy; D008099:Liver / Q000201:enzymology; D008288:Malaria / Q000188:drug therapy; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D010962:Plasmodium berghei; D011621:Pteridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
D000962:Antimalarials; D005493:Folic Acid Antagonists; D011621:Pteridines; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate