Interferon induction in mice by lipopolysaccharide from Brucella abortus.
Endotoxin or lipopolysaccharide isolated from Brucella abortus (strain 456) produced a typical endotoxin-type interferon response in mice with peak levels of the inhibitor occurring 2 h after intravenous injection of the stimuli. Brucella lipopolysaccharide was a much less effective interferon stimulus than the lipopolysaccharide isolated from Salmonella typhimurium (strain LT-2).
D000818:Animals; D002003:Brucella abortus / Q000276:immunology*; D003513:Cycloheximide / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000276:immunology
D004731:Endotoxins; D007369:Interferon Inducers; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D007372:Interferons; D003513:Cycloheximide