Direct evidence for a colchicine-induced impairment in the mobility of membrane components.
Freeze-etch electron microscopy was used to show that colchicine interacts with membranes of the ciliate protozoan Tetrahymena pyriformis. Colchicine impairs the temperature-induced translational and vertical mobility of the membrane-intercalating particles of the freeze-fractured alveolar membranes lying just below the plasma membranes.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D005613:Freeze Etching; D008055:Lipids; D008854:Microscopy, Electron; D011506:Proteins; D013696:Temperature; D013769:Tetrahymena pyriformis
D008055:Lipids; D011506:Proteins; D003078:Colchicine