The inhibition of human placental diamine oxidase by substrate analogues.
1. The oxidation of p-dimethylaminomethylbenzylamine by purified placental diamine oxidase was followed by measuring the change in E(250) caused by the production of p-dimethylaminomethylbenzaldehyde. 2. The inhibition of this reaction by substrate analogues such as isothiouronium, guanidinium, dimethylsulphonium and trimethylammonium compounds was extensively studied. 3. The type and degree of inhibition by mono- and bis-onium compounds is described, and a theory is developed to explain the type of inhibition produced.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000588:Amines / Q000494:pharmacology; D001593:Benzyl Compounds / Q000494:pharmacology; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000588:Amines; D001593:Benzyl Compounds; D006146:Guanidines; D000644:Quaternary Ammonium Compounds; D006631:Amine Oxidase (Copper-Containing)