A comparison of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor).
A comparison has been made of the electrophoretic behavior, chemical composition, amino-terminal sequence, and immunological properties of bovine prothrombin, factor IX (Christmas factor), and factor X (Stuart factor). Some immunological crossreactivity was found between the antibody to prothrombin and factor X although prothrombin and factor X differ substantially in amino-acid and carbohydrate composition. Considerable amino-acid sequence homology was found in the amino-terminal portion of prothrombin, factor IX, and the light chain of factor X. These data provide further evidence to support the hypothesis that at least three of the vitamin K-dependent clotting factors have evolved from a common ancestral gene.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002417:Cattle; D003429:Cross Reactions; D004586:Electrophoresis; D004589:Electrophoresis, Disc; D005164:Factor IX / Q000032:analysis*; D005170:Factor X / Q000032:analysis*; D006595:Hexosamines / Q000032:analysis; D006601:Hexoses / Q000032:analysis; D007118:Immunoassay; D005779:Immunodiffusion; D009438:Neuraminic Acids / Q000032:analysis; D011516:Prothrombin / Q000032:analysis*
D000596:Amino Acids; D006595:Hexosamines; D006601:Hexoses; D009438:Neuraminic Acids; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X