Use of cerebrospinal fluid drawn at pneumoencephalography in the study of monoamine metabolism in man.
Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in CSF obtained after injection of air during pneumoencephalography (PEG) than in lumbar CSF, as drawn before the injection. There was a high correlation between levels in the `mixed' and lumbar samples of CSF in the case of each of the two acids. The concentration of lumbar HVA, but not that of 5-HIAA, was negatively correlated with CSF pressure. 5-HIAA levels were low in both samples of CSF in a group of epileptics, by comparison with controls. In two patients with Kufs disease and in one with Niemann-Pick disease, the concentration of HVA was very low in the lumbar sample. The application of a standardized PEG technique in the study of monoamine metabolism in man is suggested.
D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000134:cerebrospinal fluid*; D004833:Epilepsy, Temporal Lobe / Q000134:cerebrospinal fluid; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007427:Intracranial Pressure; D008064:Lipidoses / Q000134:cerebrospinal fluid; D008297:Male; D008722:Methods; D008875:Middle Aged; D009542:Niemann-Pick Diseases / Q000134:cerebrospinal fluid; D010300:Parkinson Disease / Q000134:cerebrospinal fluid; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011011:Pneumoencephalography; D012559:Schizophrenia / Q000134:cerebrospinal fluid; D013577:Syndrome
D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid