Toxicology studies with d-tetrandrine (NSC-77037), a plant alkaloid with vascular and lymphotoxic effects in dogs and monkeys.
D000470:Alkaloids / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D004988:Ethers, Cyclic / Q000008:administration & dosage / Q000633:toxicity; D000882:Haplorhini; D006327:Heart Block / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D008251:Macaca; D013154:Spleen / Q000187:drug effects / Q000473:pathology
D000470:Alkaloids; D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D007546:Isoquinolines