Inhibition of prostaglandin biosynthesis by 7-oxa- and 5-oxa-prostaglandin analogues.
Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure-activity relationships were ascertained.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D001681:Biological Assay; D002417:Cattle; D003106:Colon; D005849:Gerbillinae; D007700:Kinetics; D008297:Male; D009097:Multienzyme Complexes / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis*; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014316:Tritium
D001095:Arachidonic Acids; D009097:Multienzyme Complexes; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D014316:Tritium; D010105:Oxygenases