Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey.
Fenfluramine, over a dose range from 0.003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital. This absence of a positive reinforcing effect could not be attributed to a slow onset of drug effect or to the use of behaviorally inactive doses. Fenfluramine, because of its distinctive properties, may produce fewer problems of human abuse than do amphetamine-type agents.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight; D003042:Cocaine / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior; D005277:Fenfluramine / Q000008:administration & dosage / Q000494:pharmacology*; D005508:Food Deprivation; D000882:Haplorhini; D006801:Humans; D007275:Injections, Intravenous; D008251:Macaca; D008723:Methohexital / Q000494:pharmacology; D012054:Reinforcement, Psychology; D019966:Substance-Related Disorders
D005277:Fenfluramine; D008723:Methohexital; D003042:Cocaine