The effects of increased temperature on electroretinograms of temperature-sensitive paralysis mutants of Drosophila melanogaster.
Mutations within the shibire locus of Drosophila melanogaster are non-complementing alleles which result in reversible paralysis at 29 degrees but retention of normal locomotor behavior at 22 degrees . Electroretinograms of six of the mutants have been recorded at various temperatures. Two changes occurred in the electroretinograms of flies carrying most of the alleles at high temperature: they lost the "on"- and "off"- transients of the normal electroretinogram, and the fast decay of the receptor potential was attenuated. For flies with four of the alleles, a base-line oscillation was also observed. Analysis of electroretinograms of mosaic shibire flies indicates that the loss of the transients can be attributed to both a pre-synaptic and a post-synaptic effect.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster; D004596:Electroretinography; D005838:Genotype; D006358:Hot Temperature; D009030:Mosaicism; D009043:Motor Activity; D009154:Mutation; D009420:Nervous System; D010641:Phenotype; D014785:Vision, Ocular