Synthesis of actinomycin D lactam, [1',1'-bis(L-threo- , -diaminobutyric acid)]actinomycin D.
D000613:Aminobutyrates / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D003609:Dactinomycin / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity / Q000031:analogs & derivatives; D007769:Lactams / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D007778:Lactobacillus / Q000187:drug effects; D007780:Lacticaseibacillus casei / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012516:Osteosarcoma / Q000188:drug therapy; D012513:Sarcoma, Experimental / Q000188:drug therapy
D000613:Aminobutyrates; D000903:Antibiotics, Antineoplastic; D007769:Lactams; D003609:Dactinomycin; C004826:actinomycin D lactam