Metabolic and hormonal effects of alternate infusion of hypertonic glucose and aminosol-glucose in premature infants.
The metabolic and hormonal effects of a short term (24-36 hrs), alternating intravenous administration of hypertonic (16%) glucose and Aminosol-glucose were investigated in premature infants. The majority of the infants under 1 500 g showed pathological signs and did not tolerate oral feeding. The purpose of the study was to explore an intravenous alimentation program capable of ensuring an improved amino acid utilization in terms of nitrogen balance, and to prevent some of the adverse effects of the amino acid mixture. It was thought that the hormonal state created by 16% glucose might increase the capacity of the tissues to utilize the amino acids. The relevant findings were as follows. 1. Plasma free fatty acids and amino acids decreased, plasma insulin and growth hormone increased markedly in response to 16% glucose. The plasma aminogram indicated a profound redistribution of amino acids. 2. Aminosol-glucose infusion after the 16% glucose, increased the concentration of amino acids, but only to the starting level. Thus the previously decreased alpha-amino nitrogen content allowed to avoid a hyperaminoacidaemia and a marked distortion of the plasma amino acid pattern. Administration of the amino acid-glucose mixture usually failed to maintain the previously stimulated insulin and growth hormone secretion. 3. The hormonal and metabolis responses to the intermittent infusion of hypertonic glucose and Aminosol-glucose were not associated with an improved nitrogen utilization. More than 50% of the administered amino acid nitrogen was excreted. 4. The metabolic acidosis observed under these condition was found to be variable, and practically compensated.
D000596:Amino Acids / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006982:Hypertonic Solutions; D007231:Infant, Newborn; D007234:Infant, Premature; D007328:Insulin / Q000097:blood; D010288:Parenteral Nutrition
D000596:Amino Acids; D004044:Dietary Proteins; D006982:Hypertonic Solutions; D007328:Insulin; D013006:Growth Hormone; D005947:Glucose