Antiprotozoal activity of rubratoxin B.
Growth of Tetrahymena pyriformis HSM was inhibited by a concentration of 25 mug of rubratoxin B per ml of growth medium. The inhibitory effect of aflatoxin B(1)-rubratoxin B mixtures on growth of T. pyriformis was induced by rubratoxin B only. Total cellular deoxyribonucleic acid increased in the presence of 5 mug of rubratoxin B per ml of growth medium, whereas higher concentrations (25 mug/ml of growth medium) were required before a decrease in total protein was observed.
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D009183:Mycotoxins / Q000494:pharmacology*; D010407:Penicillium; D011506:Proteins / Q000378:metabolism; D013769:Tetrahymena pyriformis / Q000187:drug effects* / Q000378:metabolism
D000981:Antiprotozoal Agents; D009183:Mycotoxins; D011506:Proteins; D004247:DNA