Simian model for the evaluation of immunity to influenza.
Rhesus monkeys (Macaca mulatta) exposed to small-particle aerosols of the Aichi strain of type A2 influenza virus responded by shedding virus from the nasopharynx for 7 to 9 days and by seroconversion (hemagglutination inhibition) 8 or 9 days after exposure. After rechallenge with the homologous virus, no replication of the organism was observed, and a serological anamnestic reaction occurred. The data indicate that the rhesus monkey is a useful primate model for evaluating induced immunity to influenza virus infection.
D000336:Aerosols; D000818:Animals; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology; D000882:Haplorhini; D006385:Hemagglutination Inhibition Tests; D007117:Immunization, Secondary; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000032:analysis; D008251:Macaca; D009093:Mucus / Q000276:immunology / Q000382:microbiology; D009666:Nose; D009975:Orthomyxoviridae / Q000276:immunology* / Q000302:isolation & purification; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D010614:Pharynx
D000336:Aerosols; D007070:Immunoglobulin A