DNA synthesis and differentiation in embryonic kidney mesenchyme in vitro.
Mitosis accompanies the differentiation of embryonic metanephrogenic mesenchyme in vitro. Inhibition of mitosis by 5-fluorodeoxyuridine, but not by x-rays, is associated with inhibition of differentiation. The difference may be due to the effect of 5-fluorode-oxyuridine on DNA synthesis.
D000818:Animals; D001345:Autoradiography; D002454:Cell Differentiation / Q000187:drug effects* / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis*; D005467:Floxuridine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000196:embryology*; D051379:Mice
D005467:Floxuridine; D004247:DNA