Sulfur mustard: reaction with L-cells treated with 5-fluorodeoxyuridine.
After exposure to 5-fluorodeoxyuridine, L-cells are considerably more sensitive to the lethal effect of sulfur mustard than after they have been released from this block by addition of thymidine and allowed to proceed into the G2 phase of the division cycle. Nevertheless, for both populations, the amounts of mustard bound per cell and per nucleus (expressed as the amount of mustard per unit of protein) were the same. Likewise, the amounts of mustard bound per unit of DNA were the same for both populations.
D000478:Alkylation; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D011232:Chemical Precipitation; D004247:DNA / Q000096:biosynthesis; D005467:Floxuridine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007739:L Cells; D051379:Mice; D009150:Mustard Compounds / Q000494:pharmacology*; D011874:Radiometry; D013460:Sulfur Isotopes; D013936:Thymidine / Q000378:metabolism
D009150:Mustard Compounds; D013460:Sulfur Isotopes; D005467:Floxuridine; D004247:DNA; D013936:Thymidine