Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. III. Crisis following therapy.
Eight grivet monkeys infected with Borrelia recurrentis received tetracycline (12.5mg/kg body weight) on the 3rd or 4th day of spirochetemia. Leukopenia, fever, hyperpnea, and tachycardia developed within 2 hours as spirochete counts fell to undetectable levels. These events closely simulated the crisis in human louse-borne relapsing fever in both timing and extent.
D000818:Animals; D001769:Blood / Q000382:microbiology; D001898:Borrelia / Q000302:isolation & purification; D004195:Disease Models, Animal; D005260:Female; D005334:Fever; D000882:Haplorhini; D006339:Heart Rate; D007303:Insect Vectors; D007958:Leukocyte Count; D007962:Leukocytes / Q000382:microbiology; D007970:Leukopenia / Q000209:etiology; D008297:Male; D008003:Phthiraptera; D012061:Relapsing Fever / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D012119:Respiration; D013610:Tachycardia / Q000097:blood; D013752:Tetracycline / Q000627:therapeutic use
D013752:Tetracycline