Developmental block in citric acid cycle mutants of Bacillus subtilis.
Mutants deficient in different enzymes of the citric acid cycle can be subdivided into two groups according to the frequency at which they produce heat-resistant spores in nutrient sporulation medium. However, the majority of cells can develop in this medium only to the axial filament stage I of sporulation; aconitase and isocitrate dehydrogenase mutants need the addition of glutamate to reach this stage.
D000154:Aconitate Hydratase / Q000096:biosynthesis; D001412:Bacillus subtilis / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism; D002250:Carbon Radioisotopes; D002952:Citric Acid Cycle; D003470:Culture Media; D005649:Fumarate Hydratase / Q000096:biosynthesis; D005971:Glutamates / Q000378:metabolism; D006358:Hot Temperature; D007521:Isocitrate Dehydrogenase / Q000096:biosynthesis; D007655:Ketoglutarate Dehydrogenase Complex / Q000096:biosynthesis; D008291:Malate Dehydrogenase / Q000096:biosynthesis; D008293:Malates / Q000378:metabolism; D008854:Microscopy, Electron; D009154:Mutation; D013171:Spores, Bacterial / Q000254:growth & development; D013385:Succinate Dehydrogenase / Q000096:biosynthesis
D002250:Carbon Radioisotopes; D003470:Culture Media; D005971:Glutamates; D008293:Malates; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase; D005649:Fumarate Hydratase; D000154:Aconitate Hydratase