Tissue reactions to two fissure sealant resina.
Specimens of polymerized and unpolymerized Nuva-Seal and Alpha-Seal were implanted subcutaneously on polythene rods. Polymerized specimens caused only slightly greater reaction than controls over intervals of from 2 days to 1 year. Unpolymerized specimens caused necrosis, marked inflammatory cell infiltration and granulation tissue formation for up to 1 week but were similar to the controls at 1 year. No reaction to unpolymerized resin painted on the oral mucosa was observed.
D000818:Animals; D003764:Dental Materials / Q000494:pharmacology*; D005347:Fibroblasts / Q000648:ultrastructure; D005549:Foreign-Body Reaction; D006097:Granulation Tissue / Q000648:ultrastructure; D008214:Lymphocytes / Q000648:ultrastructure; D008264:Macrophages / Q000648:ultrastructure; D009061:Mouth Mucosa / Q000187:drug effects* / Q000648:ultrastructure; D010895:Pit and Fissure Sealants / Q000008:administration & dosage / Q000494:pharmacology*; D011108:Polymers / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000648:ultrastructure
D003764:Dental Materials; D010895:Pit and Fissure Sealants; D011108:Polymers