Nature of the elimination of the penicillinase plasmid from Staphylococcus aureus by surface-active agents.
Growth of Stapylococcus aureus in various ionic surface-active agents resulted in loss of the ability to produce penicillinase, whereas growth in nonionic surface-active agents had no effect on penicillinase production. The curing effect of various alkyl sulfates was found to be dependent upon the chain length. Curing by surface-active agents could be inhibited by magnesium. Reciprocal transduction experiments showed that curing by a surface-active agent was a property of the plasmid, not of the bacterial strain in which the plasmic resides.
D003470:Culture Media; D003840:Deoxycholic Acid / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D005111:Extrachromosomal Inheritance; D005796:Genes / Q000187:drug effects*; D008274:Magnesium / Q000494:pharmacology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013210:Staphylococcus / Q000201:enzymology* / Q000254:growth & development; D013501:Surface-Active Agents / Q000494:pharmacology*; D014161:Transduction, Genetic
D003470:Culture Media; D013501:Surface-Active Agents; D003840:Deoxycholic Acid; D012967:Sodium Dodecyl Sulfate; D004492:Edetic Acid; D010405:Penicillinase; D008274:Magnesium