Studies of Escherichia coli in gnotobiotic pigs 3. Evaluation of orally administered specific antisera.
The protective effect of orally administered immune (E. COLI 08:K.:H21) serum was demonstrated in experimentally infected gnotobiotic pigs. The temporary protective effect of the immune serum and the correlation of protection with IN VITRO antibody determinations were discussed. The results indicated that the protective action of the immune serum is apparently not dependent upon the complement-antibody bactericidal system. It was suggested that the most plausible mechanism of action of the immune serum was the inactivation of endotoxin in the lumen of the intestine.
D000818:Animals; D003967:Diarrhea / Q000150:complications; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology*; D007106:Immune Sera / Q000008:administration & dosage*; D007116:Immunization, Passive; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
D007106:Immune Sera