title: Salicylanilides: a new group of active uncouplers of oxidative phosphorylation.
abstract: Investigations using housefly mitochondria revealed several salicylanilide derivatives as the most effective uncoupling agents of oxidative phosphorylation reported so far. Even greater inhibition of the associated P(i)-adenosine triphosphate exchange was shown with these compounds in both housefly and rat-liver mitochondria, and close similarity was observed between the two types of organelles.
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000255:Adenosine Triphosphate / Q000378:metabolism; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D006793:Houseflies; D008928:Mitochondria / Q000378:metabolism; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*
chemical_list: D000813:Anilides; D004140:Dinitrophenols; D009840:Oligomycins; D012459:Salicylates; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases