title: Regional distribution of acid mucopolysaccharides in the kidney.
abstract: Kidneys from 20 dogs were dissected into cortical and medullary components and analysed for acid mucopolysaccharide content. Heparitin sulfate accounted for approximately 80% of cortical acid mucopolysaccharide, 10% was chondroitin sulfate B, and 10% was low molecular weight hyaluronic acid. Medullary tissue exhibited a 4- to 5-fold higher concentration of acid mucopolysaccharide than did cortical tissue, and the dominant compound was moderately highly polymerized hyaluronic acid. While chondroitin sulfates A and (or) C were not detected in this study, the presence of minor amounts of these substances could not be excluded. A model experiment indicated that hyaluronic acid retards sodium diffusion, apparently due to its viscous properties rather than its electronegativity.
mesh_terms: D000818:Animals; D001692:Biological Transport; D002807:Chondroitin / Q000032:analysis; D002845:Chromatography; D004058:Diffusion; D004285:Dogs; D006025:Glycosaminoglycans / Q000032:analysis*; D006493:Heparin / Q000032:analysis; D006820:Hyaluronic Acid / Q000032:analysis; D007668:Kidney / Q000032:analysis* / Q000378:metabolism; D008954:Models, Biological; D012964:Sodium / Q000378:metabolism; D013431:Sulfates; D014783:Viscosity
chemical_list: D006025:Glycosaminoglycans; D013431:Sulfates; D006820:Hyaluronic Acid; D006493:Heparin; D002807:Chondroitin; D012964:Sodium