title: Cells involved in cell-mediated and transplantation immunity. II. A consideration of the functional identity of the cells involved in both humoral and cell-mediated immunity: a phylogenetic approach.
abstract: The literature concerned with the types of cells that participate in the humoral and cell-mediated immune response has been reviewed. It is postulated that the initial cells that are involved in mediating both types of immunity are functionally identical in that both are antigen-reactive cells. In the case of the humoral immune response, the interaction of the antigen-reactive cells with the antigen leads to the release or transfer of "information" to the antibody-forming cell, resulting in the synthesis and secretion of antibody molecules. In the case of cell-mediated immunity, it is considered that the primitive antigen-reactive cell itself transforms into the sensitized cell which infiltrates the site of antigen administration.
mesh_terms: D000906:Antibodies; D000937:Antigen-Antibody Reactions; D000941:Antigens; D001183:Arthus Reaction / Q000276:immunology; D003165:Complement System Proteins; D006968:Hypersensitivity, Delayed; D007110:Immunity, Active; D007112:Immunity, Maternally-Acquired; D007962:Leukocytes / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D000906:Antibodies; D000941:Antigens; D003165:Complement System Proteins