3-acetylpyridine: effects in vitro related to teratogenic activity in chicken embryos.
Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide-or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002356:Cartilage / Q000187:drug effects / Q000196:embryology; D002454:Cell Differentiation / Q000187:drug effects; D002642:Chick Embryo / Q000187:drug effects*; D046508:Culture Techniques; D005121:Extremities / Q000196:embryology; D009132:Muscles / Q000187:drug effects / Q000196:embryology*; D009536:Niacinamide / Q000494:pharmacology; D011725:Pyridines / Q000633:toxicity*
D011725:Pyridines; D009536:Niacinamide