The influence of psychotropic drugs on aldole, mitochondrial malic dehydrogenase and Mg++na+K+ adenosine triphosphatase.
1. The experiment investigated the effects of psychotropic drugs on enzymes in vitro.2. Chlorpromazine inhibits mitochondrial malate dehydrogenase in concentrations of 1.4x10(-4)M and above. No effect was observed below this concentration.3. A sharp inflection in the [unk]/drug plot was also seen with chlorpromazine (1.4 x 10(-4)M), trifluoperazine (1 x 10(-5)M), prochlorperazine (1 x 10(-4)M), and amylobarbitone (8 x 10(-3)M) acting on rat brain (Na(+)-K(+)-) Mg(++)-ATPase and with chlorpromazine (10(-4)M) and imipramine (3 x 10(-4)M) acting on aldolase.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology; D002746:Chlorpromazine / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors*; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008931:Mitochondria, Muscle / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology; D011346:Prochlorperazine / Q000494:pharmacology; D011817:Rabbits; D013552:Swine; D014149:Tranquilizing Agents / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology
D014149:Tranquilizing Agents; D014268:Trifluoperazine; D008291:Malate Dehydrogenase; D000251:Adenosine Triphosphatases; D005634:Fructose-Bisphosphate Aldolase; D000654:Amobarbital; D007099:Imipramine; D002746:Chlorpromazine; D011346:Prochlorperazine