title: Methotrexate therapy of head and neck cancer: improvement in therapeutic index by the use of leucovorin "rescue".
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D003875:Drug Eruptions; D004357:Drug Synergism; D005153:Facial Neoplasms / Q000188:drug therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D007970:Leukopenia / Q000139:chemically induced; D008048:Lip Neoplasms / Q000188:drug therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy*; D009092:Mucous Membrane / Q000187:drug effects; D010157:Palatal Neoplasms / Q000188:drug therapy; D010610:Pharyngeal Neoplasms / Q000188:drug therapy; D014062:Tongue Neoplasms / Q000188:drug therapy
chemical_list: D002955:Leucovorin; D008727:Methotrexate