Prevention of staphylococcal bacteriophage activity by antigen A precipitins in human sera.
Antigen A precipitins in human sera prevented plaque formation and propagation of staphylococcal bacteriophages. Over 20% of total IgG was removed from human sera by absorption with staphylococci containing antigen A. The specific precipitating antibody in rabbit antisera formed lines of idenity with antigen A precipitins in lower dilutions of human sera but formed lines of nonidenity with antigen A precipitins in higher dilutions of the same sera, suggesting both specific and nonspecific antigen A precipitins in human sera. The specific and nonspecific antigen A precipitins in human sera may prevent the in vivo activity of staphylococcal bacteriophages which have been demonstrated previously in animals whose sera do not contain either specific or nonspecific antigen A precipitins.
D000998:Antiviral Agents / Q000494:pharmacology; D001769:Blood; D005779:Immunodiffusion; D011234:Precipitins / Q000494:pharmacology*; D013210:Staphylococcus / Q000276:immunology; D013204:Staphylococcus Phages / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011234:Precipitins