C14-proline metabolism in alloxan treated rats.
The metabolism of C(14) proline was studied for a brief incorporation period during the early phases of alloxan treatment. The study showed that 150 gm alloxan-diabetic rats excreted a large quantity of prolyl rich peptides in the urine which is indicative of a failure in hydroxylation in the diabetic animals. The data from the skin confirmed this. Possible explanations were presented.
D000818:Animals; D002247:Carbon Isotopes; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006909:Hydroxyproline / Q000652:urine; D010455:Peptides / Q000652:urine; D011392:Proline / Q000378:metabolism* / Q000652:urine; D051381:Rats
D002247:Carbon Isotopes; D010455:Peptides; D011392:Proline; D006909:Hydroxyproline