17 beta-estradiol: inducer of uterine hexokinase.
Administration of estradiol to ovariectomized rats induced new synthesis of uterine hexokinase which was prevented by actinomycin D, 5-fluorouracil, cycloheximide, or ethionine. The estradiol-induced increase in uterine hexokinase activity was detectable as early as 4 hours. The increase in enzyme activity was dependent upon the dose of the hormone. The evidence indicates that the increased hexokinase activity induced by 17beta-estradiol may entail an acceleration of the synthesis of certain RNA species.
D000818:Animals; D002369:Castration; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists; D005001:Ethionine / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006593:Hexokinase / Q000096:biosynthesis*; D007700:Kinetics; D010053:Ovary / Q000601:surgery; D010732:Phosphofructokinase-1 / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D014599:Uterus / Q000187:drug effects / Q000201:enzymology*
D004965:Estrogen Antagonists; D003609:Dactinomycin; D004958:Estradiol; D012313:RNA; D003513:Cycloheximide; D006593:Hexokinase; D010732:Phosphofructokinase-1; D005472:Fluorouracil; D005001:Ethionine