title: Mode of action of albocycline, an inhibitor of nicotinate biosynthesis.
abstract: The antibiotic albocycline blocks the synthesis of nicotinate or nicotinamide in Bacillus subtilis cells. The inhibitory activity of the agent is fully reversed by nicotinic acid, nicotinamide, and, to a moderate extent, also by quinolinate. This suggests that in B. subtilis the antibiotic interferes with a reaction step occurring prior to the formation of quinolinate within the biosynthetic pathway leading to nicotinate.
mesh_terms: D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D009536:Niacinamide / Q000494:pharmacology; D009539:Nicotinic Acids / Q000096:biosynthesis* / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009539:Nicotinic Acids; D011725:Pyridines; D009536:Niacinamide