A cytoplasmically transmitted, diet-dependent difference in response to the teratogenic effects of 6-aminonicotinamide.
The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F(1) mothers are maintained on Lab Chow but not on Breeder Chow.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced*; D004032:Diet; D005111:Extrachromosomal Inheritance; D005260:Female; D006824:Hybridization, Genetic; D007178:Inbreeding; D008431:Maternal-Fetal Exchange; D051379:Mice; D009536:Niacinamide / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal
D009536:Niacinamide