title: Erythrocyte abnormality in human myopathy.
abstract: Erythrocyte ghosts isolated from myopathic patients responded to 10(-4) molar ouabain with a dramatic increase in adenosine triphosphatase activity, while identical preparations from normal donors were inhibited by the same drug. These results have been interpreted in terms of a disease-related change in membrane integrity bearing upon function of the transport enzyme.
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D001693:Biological Transport, Active; D002462:Cell Membrane; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D008875:Middle Aged; D009135:Muscular Diseases / Q000378:metabolism*; D009136:Muscular Dystrophies; D009222:Myotonia; D010042:Ouabain / Q000494:pharmacology*
chemical_list: D010042:Ouabain; D000251:Adenosine Triphosphatases