title: Lactones as inhibitors of the fibrinolytic system.
abstract: Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.
mesh_terms: D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D004798:Enzymes; D005341:Fibrinolysin; D006801:Humans; D066298:In Vitro Techniques; D007783:Lactones
chemical_list: D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D004798:Enzymes; D007783:Lactones; D005341:Fibrinolysin