title: A new influenza A virus infection in turkeys. VII. Comparative immunology.
abstract: Four influenza A strains isolated from turkeys in Ontario as well as strain Chicken/Scotland/59 were found to immunize turkeys against the lethal disease caused by virus Turkey/Ontario 7732/66 (V7732). These viruses form the avian influenza A serotype 5 (AA5). Immunoprotection against V7732 was not obtained with influenza viruses of other serotypes. Immunoprotective relationships among AA5 viruses were not always demonstrable in hemagglutination-inhibition (HI) and serum-neutralization (SN) tests, especially with turkey and mammalian antisera; better correlation between immunoprotection and these in vitro tests was seen with chicken antisera. The implications of these findings relative to virus classification, serodiagnosis and vaccination are discussed.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis; D002645:Chickens; D003429:Cross Reactions; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D009500:Neutralization Tests; D009975:Orthomyxoviridae / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000662:veterinary*; D011201:Poultry Diseases / Q000276:immunology*; D011817:Rabbits; D051381:Rats; D012703:Serotyping; D014422:Turkeys
chemical_list: D000941:Antigens; D007106:Immune Sera