Lactones as inhibitors of the fibrinolytic system.
Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.
D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D004798:Enzymes; D005341:Fibrinolysin; D006801:Humans; D066298:In Vitro Techniques; D007783:Lactones
D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D004798:Enzymes; D007783:Lactones; D005341:Fibrinolysin