Some observations on the diagnosis and epidemiology of leptospirosis in swine.
The results of combined epidemiological, clinical, serological, bacteriological and histopathological studies following an outbreak of disease caused by L. pomona on a farm stocked with cattle, sheep, pigs, goats and horses maintained for experimental purposes, are reported.The incidence of infection was high in horses, cattle and pigs. A few low titres were seen in sheep. The goats were not infected. Apart from a single bovine abortion all the clinical symptoms observed occurred in pregnant sows. Seven of these aborted or gave birth to stillborn pigs within a six week period. Fifteen species of wildlife were trapped or shot on the farm during the year following the outbreak. L. pomona was isolated from four skunks and a porcupine. Epidemiological studies indicated that wildlife reservoir hosts were the primary source of infection for the domestic livestock. Leptospiruria and the serological response were studied in a group of eight infected sows. Microscopic agglutination titres of 10(2) or less could not be associated with leptospiruria and the duration of leptospiruria was found to range from a few weeks to over two years in individual sows. Direct dark-field examination of urine proved superior to guinea-pig inoculation as a method of detecting leptospiruria and it is suggested that the former technique could be adopted with advantage as a routine aid to diagnosis.
D000372:Agglutination Tests; D000818:Animals; D006168:Guinea Pigs; D006652:Histological Techniques; D007919:Leptospira / Q000302:isolation & purification; D007922:Leptospirosis / Q000175:diagnosis / Q000453:epidemiology* / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis*; D014556:Urine / Q000382:microbiology