title: Increase of dihydrofolate reductase activity in cultured mammalian cells after exposure to methotrexate.
mesh_terms: D046508:Culture Techniques; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D005467:Floxuridine / Q000494:pharmacology; D006801:Humans; D007930:Leucine / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D008727:Methotrexate / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009705:Nucleosides / Q000378:metabolism; D011691:Puromycin / Q000494:pharmacology; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014316:Tritium
chemical_list: D009363:Neoplasm Proteins; D009705:Nucleosides; D012334:RNA, Neoplasm; D005467:Floxuridine; D014316:Tritium; D003609:Dactinomycin; D011691:Puromycin; D003513:Cycloheximide; D013762:Tetrahydrofolate Dehydrogenase; D007930:Leucine; D008727:Methotrexate