Mithramycin treatment of hypercalcaemia and renal failure in a patient with paratesticular embryonic sarcoma.
A 17-year-old patient with a small paratesticular embryonic sarcoma presented with symptoms of renal failure, polyuria and widespread bone metastases. Investigation revealed hypercalcaemia and uraemia without any evidence of hyperparathyroidism. The hypercalcaemia responded over a period of weeks to administration of mithramycin with initial improvement in the symptoms and metabolic derangements. Control was lost with the necrosis of intra-abdominal tumour deposits and haemorrhagic polypoid deposits in the alimentary tract. The value and hazards of mithramycin are well demonstrated by these rare complications of this type of tumour.
D000008:Abdominal Neoplasms; D000293:Adolescent; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D006471:Gastrointestinal Hemorrhage; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D007417:Intestinal Polyps; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008637:Mesenchymoma / Q000150:complications / Q000188:drug therapy*; D009336:Necrosis; D009362:Neoplasm Metastasis; D008926:Plicamycin / Q000627:therapeutic use; D011141:Polyuria / Q000209:etiology; D011859:Radiography; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy*; D014511:Uremia / Q000209:etiology
D000903:Antibiotics, Antineoplastic; D008926:Plicamycin; D006854:Hydrocortisone