title: Regulation of phosphate metabolism in Neurospora crassa. Characterization of regulatory mutants.
abstract: A mutant of Neurospora crassa, called UW-6, differs from wild type in being partially constitutive for synthesis of a species of alkaline phosphatase, and also for a species of phosphate permease that has a high affinity for phosphate at high pH. UW-6 is possibly allelic with a mutant called nuc-2 that was previously isolated by Ishikawa. nuc-2 has the converse phenotype, in that it cannot be derepressed for either of these two activities. UW-6 is co-dominant with its wild-type allele in heterokaryons and in partial diploids. An unlinked mutant, nuc-1, is like nuc-2 in that it fails to make the alkaline phosphatase or the permease referred to above. nuc-1 is epistatic to UW-6 in the double mutant. The control of phosphorus metabolism is discussed, and is compared with some other control systems in filamentous fungi.
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D001692:Biological Transport; D002455:Cell Division; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003434:Crossing Over, Genetic; D004171:Diploidy; D005809:Genes, Regulator; D006863:Hydrogen-Ion Concentration; D026901:Membrane Transport Proteins / Q000096:biosynthesis*; D008715:Methionine / Q000494:pharmacology; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000187:drug effects / Q000201:enzymology; D010641:Phenotype; D010710:Phosphates / Q000378:metabolism* / Q000494:pharmacology; D010761:Phosphorus Radioisotopes; D013431:Sulfates / Q000494:pharmacology; D013696:Temperature
chemical_list: D026901:Membrane Transport Proteins; D010710:Phosphates; D010761:Phosphorus Radioisotopes; D013431:Sulfates; D008715:Methionine; D000469:Alkaline Phosphatase