title: Lead poisoning in chickens and the effect of lead on interferon and antibody production.
abstract: The effect of aqueous lead acetate given per os to chickens for 35 consecutive days and the effect of lead on interferon and antibody production was investigated. Chickens were found to tolerate levels of lead as high as 160 mg/kg/day without exhibiting clinical signs or hematological changes in spite of very high levels of lead in the blood (6.2 ppm). It is apparent from these findings that chickens are more resistant to lead poisoning than humans, horses, dogs and wild fowl such as ducks. Subclinical lead doses did not affect interferon induction in response to statolon and Newcastle Disease virus (NDV)-B(1). Interferon concentrations and duration in serum were markedly decreased in chickens which received lead at the 320 mg/kg level. Long time lead exposure had no marked effect on antibody production to NDV in chickens. No consistent correlation was observed between blood lead concentration and antibody titer. The results of these studies indicate that long term subclinical lead intake suppresses neither interferon nor antibody production in chickens.
mesh_terms: D000085:Acetates / Q000008:administration & dosage; D000284:Administration, Oral; D000740:Anemia / Q000662:veterinary; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002478:Cells, Cultured; D002645:Chickens; D005347:Fibroblasts; D006454:Hemoglobins / Q000032:analysis; D007372:Interferons / Q000096:biosynthesis*; D007854:Lead / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D007855:Lead Poisoning / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D009522:Newcastle disease virus / Q000276:immunology; D009975:Orthomyxoviridae; D010243:Paralysis / Q000662:veterinary; D011070:Poly I-C / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology; D011201:Poultry Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology
chemical_list: D000085:Acetates; D006454:Hemoglobins; D011134:Polysaccharides; D007854:Lead; D007372:Interferons; D011070:Poly I-C