Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat.
AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Delta 7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol. In all tissues studied, with the exception of the lens, there was a reduction in cholesterol and a marked accumulation of 7-dehydrocholesterol. Isotope studies showed a reduced uptake of acetate into cholesterol, and an increased uptake into 7-dehydrocholesterol, in various tissues in vivo and by skin samples in vitro. There was no apparent accumulation of lanosterol or of the methostenols in the rat skin.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001011:Aorta / Q000378:metabolism; D002762:Cholecalciferol / Q000378:metabolism; D002784:Cholesterol / Q000302:isolation & purification*; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012867:Skin / Q000378:metabolism
D000924:Anticholesteremic Agents; D002762:Cholecalciferol; D002784:Cholesterol