Metabolism of nitrosamines in vivo. II. On the methylation of nucleic acids by aliphatic di-n-alkyl-nitrosamines in vivo, caused by beta-oxydation: the increased formation of 7-methyl-guanine after application of beta-hydroxypropyl-propyl-nitrosamine compared to that after application of di-n-propyl-nitrosamine.
D000818:Animals; D001665:Binding Sites; D002250:Carbon Radioisotopes; D004247:DNA / Q000032:analysis; D006147:Guanine / Q000032:analysis / Q000096:biosynthesis; D006900:Hydroxylation; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008745:Methylation; D009602:Nitrosamines / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism; D009696:Nucleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D012313:RNA / Q000032:analysis; D051381:Rats
D002250:Carbon Radioisotopes; D009602:Nitrosamines; D009603:Nitroso Compounds; D009696:Nucleic Acids; D006147:Guanine; D012313:RNA; D004247:DNA