title: The distribution and some effects of polychlorinated biphenyls (Aroclor 1254) in cockerels during prolonged feeding trial.
abstract: A ration containing 500 ppm of polychlorinated biphenyls (PCB) was fed to one month old cockerels for periods up to 12 weeks. The distribution of PCB was determined in the brain, liver, kidneys and blood as well as in the muscular and adipose tissues. Tissue concentrations of PCB increased linearly with time. Small changes were detected on the chromatograms of the liver, fat and blood extracts.A significant decrease in the size of the combs and testicles in PCB-treated birds was noted. This decrease appeared as early as one week after the start of PCB administration.
mesh_terms: D000273:Adipose Tissue / Q000032:analysis; D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D001713:Biphenyl Compounds / Q000032:analysis*; D001923:Brain Chemistry; D002645:Chickens / Q000378:metabolism*; D002849:Chromatography, Gas; D003129:Comb and Wattles / Q000033:anatomy & histology; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000033:anatomy & histology; D008297:Male; D009132:Muscles / Q000032:analysis; D009929:Organ Size; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology; D013737:Testis / Q000033:anatomy & histology; D013997:Time Factors
chemical_list: D001713:Biphenyl Compounds; D011078:Polychlorinated Biphenyls