The failure of aldose reductase inhibitor 3,3'-tetramethylene glutaric acid to inhibit in vivo sorbitol accumulation in lens and retina in diabetes.
D000284:Administration, Oral; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002241:Carbohydrates / Q000032:analysis; D002849:Chromatography, Gas; D003517:Cyclopentanes / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism*; D005977:Glutarates / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D006207:Half-Life; D006400:Hematocrit; D007267:Injections; D007275:Injections, Intravenous; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D009915:Orbit; D011817:Rabbits; D051381:Rats; D012160:Retina / Q000378:metabolism*; D013012:Sorbitol / Q000378:metabolism*; D013311:Streptozocin; D013997:Time Factors
D002241:Carbohydrates; D003517:Cyclopentanes; D005977:Glutarates; D013012:Sorbitol; D013311:Streptozocin; D000429:Alcohol Oxidoreductases