title: Ruptured aneurysms of sinuses of Valsalva.
abstract: At least one additional cardiac lesion was present in 18 consecutive patients with ruptured aneurysms of the sinuses of Valsalva who were investigated between 1956 and 1973 at the University of Alberta Hospital. Clinical diagnosis was made in 78% (14/18) of the patients. Confirmation at cardiac catheterization, operation or autopsy was obtained in all but one. The main sites of rupture were the right ventricle (seven cases), right atrium (five) and left ventricle (five). Fifty percent (9/18) are alive and well following prompt operative repair, an average of 8.2 years later (range, six months to 15 years). Replacement of the aortic valve was associated with a high mortality (50% early, 13% late, total 63%) which could be explained by the higher operative risk in this group of very ill patients. Eight patients (44.4%) had had bacterial endocarditis prior to presentation and this may have played a significant role in the rupture of the sinus of Valsalva aneurysm.
mesh_terms: D000293:Adolescent; D000328:Adult; D000416:Alberta; D000790:Angiocardiography; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000150:complications / Q000601:surgery; D006328:Cardiac Catheterization; D006332:Cardiomegaly / Q000209:etiology; D002675:Child, Preschool; D004562:Electrocardiography; D004696:Endocarditis / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006322:Heart Aneurysm / Q000150:complications / Q000151:congenital / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000150:complications; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000150:complications; D012422:Rupture, Spontaneous / Q000175:diagnosis / Q000401:mortality / Q000601:surgery