Enduring behavioral changes in rats with experimental phenylketonuria.
Several criticisms of past attempts to produce experimental phenylketonuria are discussed, and a model that appears to meet these criticisms is presented. This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood. By this method, an experimental subject is produced whose behavioral, neurological, and biochemical characteristics are similar to those of clinical patients with phenylketonuria.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal; D001921:Brain / Q000473:pathology; D003672:Defecation / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009929:Organ Size; D010649:Phenylalanine / Q000494:pharmacology; D010651:Phenylalanine Hydroxylase / Q000037:antagonists & inhibitors; D010661:Phenylketonurias / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D010649:Phenylalanine; D010651:Phenylalanine Hydroxylase; D010134:Fenclonine