Vasculitis with alclofenac therapy.
Three patients developed a vasculitis while taking alclofenac. Two recovered with corticosteroid therapy, and the third, who had continued to take the drug for a further week despite epistaxis, haemoptysis, haematuria, and cutaneous vasculitis, developed a more persistent vasculitis with histological evidence of progressive renal involvement.
D000368:Aged; D000498:Allyl Compounds / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects*; D001706:Biopsy; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010647:Phenyl Ethers / Q000009:adverse effects; D010648:Phenylacetates / Q000009:adverse effects*; D011239:Prednisolone / Q000627:therapeutic use; D014652:Vascular Diseases / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D000498:Allyl Compounds; D000700:Analgesics; D010647:Phenyl Ethers; D010648:Phenylacetates; D011239:Prednisolone