Binding of oligosaccharides of hyaluronic acid to proteoglycans.
Oligosaccharides derived from hyaluronic acid were shown to inhibit proteoglycan-hyaluronic acid interaction, as measured in a viscometer. The relative inhibition increased with the size of the oligosaccharide and the results suggested that decasaccharides were the smallest fragments able to bind strongly to the proteoglycan.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002850:Chromatography, Gel; D006025:Glycosaminoglycans; D006820:Hyaluronic Acid; D007817:Laryngeal Cartilages / Q000032:analysis; D046911:Macromolecular Substances; D009844:Oligosaccharides / Q000032:analysis; D013552:Swine; D014783:Viscosity
D006025:Glycosaminoglycans; D046911:Macromolecular Substances; D009844:Oligosaccharides; D006820:Hyaluronic Acid