title: The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000293:Adolescent; D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D004338:Drug Combinations; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D000882:Haplorhini; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000209:etiology; D008206:Lymphatic Diseases / Q000139:chemically induced; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011743:Pyrimidines / Q000009:adverse effects*; D051381:Rats; D013420:Sulfamethoxazole / Q000009:adverse effects* / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000139:chemically induced; D014295:Trimethoprim / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D005492:Folic Acid; D014295:Trimethoprim; D013420:Sulfamethoxazole