title: Ocular involvement with Chlamydia psittaci (strain M56) in rabbits inoculated intravenously.
abstract: Fourteen albino rabbits were inoculated intravenously with 10(3.5)-10(4.0) mouse ICLD(50) of Chlamydia psittaci (strain M56) of mammalian origin. Ocular lesions accompanied the chlamydial infection in the rabbits. Bilateral anterior uveitis, a common occurrence, began on the second or third day and subsided by the tenth day whereas keratoconjunctivitis was observed infrequently. After 15 days the most prominent microscopic lesion was iritis. Accumulations of inflammatory cells, mainly plasma cells, were observed in the iris and ciliary body and elementary bodies were found infrequently in macrophages. Chlamydiae were recovered consistently by conjunctival swabbing from the fifth to the twenty-fourth day. The agent was present within the eye (viz. iris-ciliary body) in three of four rabbits killed at 15 days and in five of ten rabbits killed 60 days after inoculation. Chlamydiae had persisted in the cerebrum and joints as well. Although neutralizing antibody was consistently present in sera at 60 days none of the samples of aqueous humor were capable of neutralizing the agent. It is suggested that systemic chlamydial infections in the rabbit provide a model for the study of endogenous uveitis, a common ophthalmological problem.
mesh_terms: D000818:Animals; D002689:Chlamydia / Q000302:isolation & purification; D002690:Chlamydia Infections / Q000209:etiology / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D002924:Ciliary Body / Q000382:microbiology / Q000473:pathology; D003228:Conjunctiva / Q000382:microbiology; D003231:Conjunctivitis / Q000473:pathology / Q000662:veterinary; D003318:Corneal Opacity / Q000473:pathology / Q000662:veterinary; D005128:Eye Diseases / Q000662:veterinary*; D007275:Injections, Intravenous; D007498:Iris / Q000382:microbiology; D007500:Iritis / Q000473:pathology / Q000662:veterinary; D051379:Mice; D011817:Rabbits