DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D003561:Cytarabine / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D005260:Female; D005552:Forelimb / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000139:chemically induced; D006918:Hydroxyurea / Q000633:toxicity; D009536:Niacinamide / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D013623:Tail / Q000002:abnormalities; D013830:Thiadiazoles / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D013830:Thiadiazoles; D003561:Cytarabine; D014316:Tritium; D009536:Niacinamide; D004247:DNA; D013936:Thymidine; D006918:Hydroxyurea