Evidence for a dissociation between positive inotropic effect and inhibition of the Na+-K+-ATPase by ouabain, cassaine and their alkylating derivatives.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006352:Heart Ventricles / Q000201:enzymology; D066298:In Vitro Techniques; D008274:Magnesium; D009150:Mustard Compounds / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology*; D011188:Potassium; D012964:Sodium; D013268:Stimulation, Chemical; D013328:Strophanthins / Q000494:pharmacology; D013997:Time Factors; D014461:Ultracentrifugation
D000477:Alkylating Agents; D009150:Mustard Compounds; D013328:Strophanthins; D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium