title: Results of a preliminary trial with Sphaerophorus necrophorus toxoids to control liver abscesses in feedlot cattle.
abstract: A preliminary field experiment was undertaken to evaluate the efficacy of alum precipitated toxoids of Sphaerophorus necrophorus prepared from sonicated whole cells and cell fractions to reduce the incidence of bovine abscesses. A total of 108 calves were divided into five groups and treated as follows: I. uninoculated control, II. adjuvant inoculated control, III. 15.5 mg protein of sonicated (fragmented cells) toxoid, IV. 10.5 mg protein of cytoplasmic toxoid. V. 15.5 mg protein of cytoplasmic toxoid. All animals were maintained under similar conditions to those prevailing in feedlots in Alberta. Livers were examined at slaughter. The most promising result was achieved with the injection of 15.5 mg protein of cytoplasmic toxoid. In this treatment group, no scars (healed lesions) were found in the liver and the incidence of liver abscesses was reduced to 10% from the average 35% liver abscesses and scars found in the uninoculated and adjuvant inoculated groups. The toxoid from sonicated whole cells did not reduce liver abscess incidence. These data suggest that the incidence of liver abscesses in cattle fattened in feedlots may be reduced by immunization.
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000821:Animal Feed; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D002498:Centrifugation; D003593:Cytoplasm; D002523:Edible Grain; D005260:Female; D005673:Fusobacterium / Q000276:immunology*; D005674:Fusobacterium Infections / Q000276:immunology / Q000517:prevention & control*; D005779:Immunodiffusion; D007279:Injections, Subcutaneous; D008100:Liver Abscess / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D008297:Male; D014121:Toxoids / Q000008:administration & dosage / Q000302:isolation & purification; D014465:Ultrasonics
chemical_list: D000276:Adjuvants, Immunologic; D014121:Toxoids