Control of experimental diabetes mellitus in rats by transplantation of fetal pancreases.
Experimental diabetes mellitus in young adult Lewis rats was successfully treated by transplantation of fetal pancreases from syngeneic fetuses. Complete or partial control lasting up to 165 days was achieved in 64 percent of recipients by using two to three pancreases of fetal age (15 to 18(1/2) days) placed under each kidney capsule. Islets of Langerhans without exocrine elements were present in the transplants.
D000818:Animals; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000601:surgery*; D005333:Fetus; D005865:Gestational Age; D006084:Graft Rejection; D007515:Islets of Langerhans / Q000196:embryology; D016381:Islets of Langerhans Transplantation; D007668:Kidney / Q000601:surgery; D008297:Male; D010179:Pancreas / Q000196:embryology; D016035:Pancreas Transplantation; D051381:Rats; D013311:Streptozocin; D014019:Tissue Donors; D014184:Transplantation, Homologous
D013311:Streptozocin