Toxicity in beagle dogs of three alkylating esters with antitumor activity: phenesterin (NSC-104469), estradiol mustard (NSC-112259), and dehydroepiandrosterone mustard (NSC-12121).
D000818:Animals; D001066:Appetite / Q000187:drug effects; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002490:Central Nervous System / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008297:Male; D008938:Mitosis / Q000187:drug effects; D009150:Mustard Compounds / Q000633:toxicity*; D009588:Nitrogen Mustard Compounds / Q000633:toxicity*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013091:Spermatogenesis / Q000187:drug effects; D000637:Transaminases / Q000097:blood; D014882:Water-Electrolyte Balance
D009150:Mustard Compounds; D009588:Nitrogen Mustard Compounds; D003687:Dehydroepiandrosterone; D004958:Estradiol; D012964:Sodium; D000637:Transaminases; D011188:Potassium