Lesions of the central nervous system induced in nonhuman primates by live influenza viruses.
Intracerebral and intraspinal inoculations of non-neuropathic and neuropathic strains of influenza virus into rhesus, patas and cercopithecus monkeys resulted in an acute focal ependymitis, choroiditis and meningitis followed by focal ependymal denuding without parenchymal involvement. Aqueductal stenosis and moderate hydrocephalus developed in two animals as sequelae of ependymal cell loss.
D000818:Animals; D001921:Brain / Q000382:microbiology; D002493:Central Nervous System Diseases / Q000209:etiology / Q000382:microbiology / Q000473:pathology*; D002535:Cerebral Aqueduct / Q000473:pathology; D002831:Choroid Plexus / Q000473:pathology; D004805:Ependyma / Q000473:pathology; D000882:Haplorhini; D006385:Hemagglutination Inhibition Tests; D007267:Injections; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D008578:Meninges / Q000473:pathology; D009975:Orthomyxoviridae / Q000276:immunology / Q000302:isolation & purification; D013131:Spine; D013788:Thalamus