Social behavior of monkeys selectively depleted of monoamines.
Initiated social interactions of Macaca speciosa are decreased during the period of treatment with alpha-methyl-p-tyrosine, an inhibitor of catecholamine synthesis. The treated animals maintained stable body weights and appeared to be healthy. Similar depletion of indoleamines with p-chlorophenylalanine does not change these same observed behaviors in spite of weight loss, hair loss, ataxia, and debilitation in some of the animals.
D000374:Aggression / Q000187:drug effects; D000588:Amines / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D002396:Catechols / Q000652:urine; D003864:Depression, Chemical; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006018:Glycols / Q000494:pharmacology / Q000652:urine; D000882:Haplorhini; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008251:Macaca; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects; D012919:Social Behavior / Q000187:drug effects*
D000588:Amines; D002395:Catecholamines; D002396:Catechols; D006018:Glycols; D008781:Methyltyrosines; D006897:Hydroxyindoleacetic Acid; D010134:Fenclonine