Studies on the malabsorption syndromes. Inhibition of (Na+-K+) ATPase of small intestine microvilli by pyrrolidone carboxylic acid.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D007082:Ileum / Q000187:drug effects / Q000201:enzymology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology*; D007583:Jejunum / Q000187:drug effects / Q000201:enzymology; D007700:Kinetics; D008286:Malabsorption Syndromes / Q000201:enzymology*; D008297:Male; D008727:Methotrexate / Q000494:pharmacology; D009928:Organ Specificity; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium; D011760:Pyrrolidinones / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000494:pharmacology; D051381:Rats; D012964:Sodium; D013329:Structure-Activity Relationship
D000596:Amino Acids; D011760:Pyrrolidinones; D010042:Ouabain; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D011761:Pyrrolidonecarboxylic Acid; D008727:Methotrexate