Prostaglandin E1 causes sedation and increases 5-hydroxytryptamine turnover in rat brain.
1. Administration of prostaglandin E(1) (1 mg/kg, i.p.) to rats induced sedation and a decrease in muscular tone. Prostaglandin E(1)-induced sedation was accompanied by the low voltage-high frequency E.E.G. pattern characteristic of the waking animal.2. Administration of prostaglandin E(1) also increased the turnover rate of 5-hydroxytryptamine and raised the concentration of acetylcholine in brain.3. The behavioural effects of prostaglandin were blocked by prior administration of p-chlorophenylalanine or pargyline, drugs which lowered the brain concentration of 5-hydroxyindoleacetic acid (5-HIAA), and was potentiated by pretreatment with probenecid, which elevated the 5-HIAA concentration. Pretreatment with atropine sulphate failed to alter prostaglandin E(1)-induced sedation.4. The results are compatible with the possibility that prostaglandin E(1) induces a state resembling paradoxical sleep through an action on 5-hydroxytryptamine metabolism in brain.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D006993:Hypnotics and Sedatives; D011453:Prostaglandins; D012701:Serotonin; D000431:Ethanol; D006897:Hydroxyindoleacetic Acid; D001285:Atropine; D010293:Pargyline; D000109:Acetylcholine; D011339:Probenecid; D010134:Fenclonine