title: Prevention of bacteriophage adsorption to Staphylococcus aureus by immunoglobulin G.
abstract: Normal human and rabbit sera when incubated with Staphylococcus aureus inhibit the adsorption of bacteriophages. The bacteriophage adsorption was also inhibited by separated normal immunoglobulin M (IgM), F(ab')(2), and Fab-fragments of IgG. No inhibition was obtained with myeloma IgG or Fc-fragments of normal human and rabbit IgG. The results indicate that the serum inhibition of bacteriophage adsorption to S. aureus is not due to a binding of IgG to protein A on the surface of S. aureus.
mesh_terms: D000327:Adsorption; D000818:Animals; D001666:Binding Sites, Antibody; D006801:Humans; D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments / Q000494:pharmacology; D007141:Immunoglobulin Fc Fragments / Q000494:pharmacology; D007074:Immunoglobulin G / Q000494:pharmacology*; D007075:Immunoglobulin M / Q000494:pharmacology; D011817:Rabbits / Q000276:immunology; D013210:Staphylococcus; D013204:Staphylococcus Phages / Q000254:growth & development*
chemical_list: D007106:Immune Sera; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M