Increased incidence of HL-A 1 and 8 in patients showing IgG or complement coating on their red cells.
The incidence of HL-A antigens in patients having a variety of medical conditions, but sharing the common feature of a positive antiglobulin test of the red cells, was determined. There was a significant increase in the antigens HL-A 1 and HL-A 8 and of the 1 and 8 combination when compared with a control group. It is suggested that the presence of these antigens may predispose to autoallergy.
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology; D003165:Complement System Proteins / Q000032:analysis*; D003298:Coombs Test; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006461:Hemolysis; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis*
D006649:Histocompatibility Antigens; D007074:Immunoglobulin G; D003165:Complement System Proteins