Effects on small-intestinal function and structure induced by feeding a deconjugated bile salt.
Feeding sodium deoxycholate orally to rats for three days caused inhibition of small-intestinal active sugar transport and ouabain-sensitive, sodium-potassium-dependent adenosine triphosphatase activity. At the same time, there was evidence of extensive ultrastructural damage to the microvillar and intracellular compartments of the small-intestinal epithelium while its light microscopic appearance was essentially normal. These functional and morphological changes reverted towards normal over the subsequent four days when a normal diet, without added bile salt, was reintroduced.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D050260:Carbohydrate Metabolism; D003840:Deoxycholic Acid / Q000494:pharmacology; D006027:Glycosides / Q000378:metabolism; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism; D008854:Microscopy, Electron; D010946:Plants, Medicinal; D051381:Rats
D001647:Bile Acids and Salts; D006027:Glycosides; D003840:Deoxycholic Acid; D000251:Adenosine Triphosphatases