Bacteriophage types and antibiotic susceptibility of Staphylococcus aureus.
In vitro tests of 132 strains of Staphylococcus aureus, among which were 38 (28.7%) heteroresistant strains, were performed with 14 commonly used antibiotics, including gentamicin and vancomycin. Heteroresistant strains were found predominantly, but not only, with group 3 phage-typable strains; no heteroresistant strain was found in out-patients. Gentamicin appeared as a uniformly effective agent at low concentrations against oxacillin-sensitive and -resistant strains. It is suggested that gentamicin should be compared to vancomycin in future clinical therapeutic trials in severe staphylococcal infections, especially in cases due to oxacillin-resistant strains.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001434:Bacteriophage Typing; D006801:Humans; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D012137:Respiratory System / Q000382:microbiology; D018805:Sepsis / Q000382:microbiology; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification; D013204:Staphylococcus Phages; D014947:Wounds and Injuries / Q000382:microbiology
D000900:Anti-Bacterial Agents; D010068:Oxacillin