DDT: disrupted osmoregulatory events in the intestine of the eel Anguilla rostrata adapted to seawater.
The drinking of seawater and absorption of water along with sodium across the intestinal epithelium are well-known osmoregulatory events in marine teleosts. The insecticide DDT impairs fluid absorption in intestinal sacs from eels adapted to seawater. Furthermore, this functional impairment has an enzymatic basis; DDT also inhibits the (Na(+) and K(+)) activated, Mg(2+)-dependent adenosine triphosphatase in homogenates of the intestinal mucosa. Thus, the extreme sensitivity of teleosts to organochlorine pollutants may involve the disruption of osmoregulatory transport mechanisms.
D000251:Adenosine Triphosphatases / Q000032:analysis / Q000037:antagonists & inhibitors; D000818:Animals; D003634:DDT / Q000494:pharmacology*; D004524:Eels / Q000187:drug effects*; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D008274:Magnesium / Q000032:analysis; D011188:Potassium / Q000032:analysis; D012623:Seawater; D012964:Sodium / Q000032:analysis; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D012964:Sodium; D003634:DDT; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium