title: Genetic control of alkaline phosphatase synthesis in Neurospora: the use of partial diploids in dominance studies.
abstract: In wild-type Neurospora, alkaline phosphatase is made under conditions of phosphate limitation, but not conditions of phosphate sufficiency. Mutants at two unlinked loci, nuc-1 and nuc-2, do not make alkaline phosphatase under any conditions, while mutants at two quite closely linked loci, pcon and preg, make alkaline phosphatase even under conditions of phosphate sufficiency. pcon is extremely closely linked to nuc-2. nuc-2 and preg(c) (constitutive) mutants are recessive to their wild-type alleles in partial diploids as well as in heterokaryons, while pcon(c) mutants are dominant or co-dominant. nuc-1 is epistatic to both pcon(c) and preg(c) mutants. The implications of these findings for theories of metabolic control in eukaryotes are briefly discussed.
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D000483:Alleles; D002467:Cell Nucleus; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D004171:Diploidy; D005796:Genes; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D006579:Heterozygote; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000166:cytology / Q000201:enzymology; D011995:Recombination, Genetic
chemical_list: D000469:Alkaline Phosphatase