Nephrotic syndrome in chronic lymphocytic leukaemia.
Two patients with chronic lymphocytic leukaemia and the nephrotic syndrome are described in whom deposits were shown in renal glomerular basement membranes in a pattern suggesting immune-complex glomerulonephritis. This renal lesion has been described in one case of squamous carcinoma of the bronchus, in one case of Burkitt's lymphoma, and in three cases of Hodgkin's disease though not previously in chronic lymphocytic leukaemia. Immune-complex glomerulonephritis is, however, a recognized finding in mice infected with leukaemogenic viruses
D000368:Aged; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D001706:Biopsy; D001798:Blood Proteins / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D002699:Chlorambucil / Q000627:therapeutic use; D003165:Complement System Proteins / Q000032:analysis; D004487:Edema / Q000150:complications; D005455:Fluorescent Antibody Technique; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000150:complications; D007105:Immune Complex Diseases / Q000473:pathology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D007945:Leukemia, Lymphoid / Q000150:complications*; D007958:Leukocyte Count; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D011507:Proteinuria; D013148:Spironolactone / Q000627:therapeutic use
D001798:Blood Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002699:Chlorambucil; D013148:Spironolactone; D005665:Furosemide; D003165:Complement System Proteins