title: Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.
mesh_terms: D000632:Aminopyrine; D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors; D000818:Animals; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008797:Metyrapone / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D009019:Morphinans; D009020:Morphine; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors*; D010634:Phenobarbital / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats
chemical_list: D009019:Morphinans; D000632:Aminopyrine; D009020:Morphine; D003577:Cytochrome P-450 Enzyme System; D010089:Oxidoreductases, N-Demethylating; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital; D008797:Metyrapone