Endogenous steroid concentrations in human breast tumours determined by high-resolution mass fragmentography.
A pilot study of the endogenous steroid concentrations in human breast tumours was performed. The technique of high-resolution molecular-ion monitoring during combined g.l.c.-mass spectrometry was used to determine oestrone, oestradiol-17beta and oestriol in concentrations above 1ng/g wet wt. of tissue, and dehydroepiandrosterone, testosterone, androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 3beta-hydroxy-5alpha-androstan-17-one in concentrations exceeding 5ng/g, in extracts of five primary breast tumours.
D000738:Androsterone / Q000032:analysis; D001943:Breast Neoplasms / Q000032:analysis*; D002849:Chromatography, Gas; D003687:Dehydroepiandrosterone / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D004964:Estriol / Q000032:analysis; D004970:Estrone / Q000032:analysis; D005260:Female; D006801:Humans; D007477:Ions / Q000032:analysis; D013058:Mass Spectrometry; D008722:Methods; D013256:Steroids / Q000032:analysis*; D013739:Testosterone / Q000032:analysis
D007477:Ions; D013256:Steroids; D004970:Estrone; D013739:Testosterone; D003687:Dehydroepiandrosterone; D004958:Estradiol; D000738:Androsterone; D004964:Estriol