Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.
The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor from the immune complex.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D004579:Electron Transport; D008293:Malates / Q000378:metabolism; D051379:Mice; D008930:Mitochondria, Liver / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000032:analysis*; D009500:Neutralization Tests; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011773:Pyruvates / Q000378:metabolism; D012402:Rotenone / Q000378:metabolism; D013386:Succinates / Q000378:metabolism
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D008293:Malates; D011773:Pyruvates; D013386:Succinates; D012402:Rotenone; D000251:Adenosine Triphosphatases