Relatedness among contractile and membrane proteins: evidence for evolution from common ancestral genes.
A statistical method for quantifying the relatedness among proteins was used to perform 2926 paired comparisons of amino-acid composition among 77 contractile and membrane-associated proteins from diverse species and sources. Relatedness of amino-acid compositions correlates with homology of amino-acid sequence. A high degree of relatedness was detected among K(+)-dependent membrane ATPase of Streptococcus faecalis, coupling factors F(1) and CF(1) from mitochondria and chloroplasts, outer fiber protein of cilia, ciliary dynein, tubulin, various actins, and myosin subfragment S-1. Heavy meromyosin and tropomyosin were related to each other but not to the first group of proteins. Differences in the degree of methylation may account for some differences in physiological function. Because of their diverse sources, the high degree of relatedness among these proteins is more compatible with evolution from common ancestral genes than with convergent evolution. Squid axon filarin, molluscan paramyosin, and bacterial flagellins appear to be unrelated either to each other or to any of the other proteins studied. Existence of persistent homologies among so many diverse proteins implies conservation of genetic information during evolution by utilization of codons for preferred amino-acid sequences in various proteins.
D000199:Actins; D000251:Adenosine Triphosphatases; D000595:Amino Acid Sequence; D000818:Animals; D001407:Bacillus / Q000032:analysis; D001426:Bacterial Proteins; D005075:Biological Evolution; D002462:Cell Membrane / Q000032:analysis*; D002736:Chloroplasts / Q000032:analysis; D013293:Enterococcus faecalis / Q000032:analysis; D005815:Genetic Code; D006801:Humans; D008974:Mollusca; D009124:Muscle Proteins; D009206:Myocardium / Q000032:analysis; D015879:Myosin Subfragments; D009218:Myosins; D010086:Oxidative Phosphorylation Coupling Factors; D011506:Proteins; D011514:Proteus vulgaris / Q000032:analysis; D011817:Rabbits; D012475:Salmonella / Q000032:analysis; D013768:Tetrahymena / Q000032:analysis; D014335:Tropomyosin
D000199:Actins; D001426:Bacterial Proteins; D009124:Muscle Proteins; D015879:Myosin Subfragments; D010086:Oxidative Phosphorylation Coupling Factors; D011506:Proteins; D014335:Tropomyosin; D000251:Adenosine Triphosphatases; D009218:Myosins