Breast cancer: induction of differentiation by embryonic tissue.
A mouse mammary tumor, adenocarcinoma BW 10232, was maintained in vitro for 14 days, separated from embryonic mammary mesenchyme by a Millipore filter. Tubules developed in the tumor; deoxyibonucleic acid synthisis declined; and a presumptive acid mucopolysaccharide matrix, not evident in the controls, appeared.
D000230:Adenocarcinoma; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D046508:Culture Techniques; D004273:DNA, Neoplasm / Q000096:biosynthesis; D006025:Glycosaminoglycans / Q000032:analysis; D006651:Histocytochemistry; D008321:Mammary Glands, Animal / Q000196:embryology*; D008325:Mammary Neoplasms, Experimental; D008648:Mesoderm / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D008851:Micropore Filters; D008938:Mitosis; D013936:Thymidine / Q000378:metabolism; D014020:Tissue Extracts / Q000302:isolation & purification / Q000494:pharmacology; D014316:Tritium
D004273:DNA, Neoplasm; D006025:Glycosaminoglycans; D014020:Tissue Extracts; D014316:Tritium; D013936:Thymidine