Different effects of thymidine and 5-fluorouracil 2'-deoxyriboside on biosynthetic events in cultured P815Y mast cells.
1. Addition of 2mm-thymidine, although resulting in the cessation of cell division, allows the continuation of phospholipid and protein synthesis and results in an increase in mean cell volume for at least 15h. 2. 5-Fluorouracil 2'-deoxyriboside inhibits cell division but differs from thymidine by inhibiting the synthesis of phospholipid and protein in a more marked manner. 3. The relation between these results and the P815Y cell cycle is discussed.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D046508:Culture Techniques; D005467:Floxuridine / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D009374:Neoplasms, Experimental; D010743:Phospholipids / Q000096:biosynthesis; D011392:Proline / Q000378:metabolism; D014176:Protein Biosynthesis; D013936:Thymidine / Q000494:pharmacology*; D013997:Time Factors
D010743:Phospholipids; D005467:Floxuridine; D011392:Proline; D013936:Thymidine