title: Enlargement of the membranous ventricular septum: an internal stigma of Down's syndrome.
abstract: A study of heart specimens without ventricular septal defect from patients with down's syndrome showed a significant enlargement of the membranous ventricular septum as compared to the normal heart. This increase in area of the ventricular septum occupied by membranous tissue from 2 to 9% may not only predispose patients with Down's syndrome to congenital heart disease, but may be one end of a spectrum of cardiac anomalies related to malalignment or maldevelopment of the ventricular septum in Down's syndrome.
mesh_terms: D001344:Autopsy; D006332:Cardiomegaly / Q000473:pathology; D004314:Down Syndrome / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000473:pathology*; D006346:Heart Septum / Q000473:pathology*; D006801:Humans