title: Treatment of gonorrheal urethritis with spectinomycin hydrochloride.
abstract: One hundred and eighty-seven males with uncomplicated gonorrheal urethritis were treated with spectinomycin hydrochloride in a dosage of 2 g. given intramuscularly. A failure rate of 3.2% was observed and no complications of therapy were encountered. In addition, 310 strains of N. gonorrhoeae were tested for susceptibility to penicillin G and spectinomycin. All strains were sensitive to 20 mug./ml. of spectinomycin and this susceptibility appeared to decrease as penicillin resistance increased. A greater incidence of relative resistance to penicillin G was observed than in similar studies from other Canadian areas.
mesh_terms: D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D000198:Spectinomycin / Q000494:pharmacology / Q000627:therapeutic use*; D014521:Urethra / Q000382:microbiology; D014526:Urethritis / Q000188:drug therapy*
chemical_list: D000198:Spectinomycin; D010400:Penicillin G