title: Observations on diseased pigs with high sulfate intake and normal tissue copper levels.
abstract: Disease in a large pig herd reared intensively and kept on sulfate-rich drinking water is described. It is the first report of diseased progeny of sows with high sulfate intake. Results of two surveys are presented, one for water with sulfate in excess of 2000 ppm and one for water with less than 1000 ppm. The management practices are described in detail. Disease of Survey I was manifested by high morbidity and mortality (50% of 600) in piglets, incoordination in piglets and some adult stock and osteopathy in piglets and weaners. In Survey II disease was less severe and restricted to piglets. Detailed histopathological studies revealed myelin deficiency in brain and spinal cord of sows and piglets, interferred endochondreal ossification of long bones of piglets and weaners, fatty changes of livers and interstitial nephritis in piglets and weaners. The changes in the nervous tissue were considered due to delayed fixation as tissue was only immersed in fixative and not perfused with it immediately after death. Similar changes have been described for pigs deficient in copper. Copper content of tissue and body fluids of pigs of this study were normal, as were the serum inorganic phosphate and total calcium levels. The bone changes observed have also been reported for rats given dextran sulfate injections, for pigs on experimental low-copper sulfate-enriched diet and for pigs reported low in copper and fed a diet supplemented with sulfide. The cause of the locomotor disturbance and mortality in piglets was not established.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001259:Ataxia / Q000473:pathology / Q000662:veterinary; D001921:Brain / Q000473:pathology; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood / Q000378:metabolism*; D005260:Female; D005269:Femur / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000473:pathology / Q000662:veterinary; D010710:Phosphates / Q000097:blood; D013116:Spinal Cord / Q000473:pathology; D013431:Sulfates / Q000008:administration & dosage / Q000009:adverse effects*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D013977:Tibia / Q000473:pathology; D014867:Water
chemical_list: D010710:Phosphates; D013431:Sulfates; D014867:Water; D003300:Copper; D002118:Calcium