title: The allografted parathyroid gland: evaluation of function in the immunosuppressed host.
abstract: Parathyroid autografts were performed in 19 random bred mongrels and parathyroid allografts were exchanged between seven random bred mongrels. Three pairs of siblings from a beagle colony were immunosuppressed and parathyroid allografts exchanged between them. The parathyroid autografts were successful, while parathyroid allografts failed on all occasions in the non-immunosuppressed host. In immunosuppressed animals, however, the allografts were successful in five of six dogs. The success of parathyroid transplantation was determined by the following observations: 1) The experimental animal, having grafted parathyroid tissue as the only source of hormone, maintained a normal or near normal serum calcium concentration. 2) Following removal of the parathyroid graft, there was an immediate fall in the serum calcium concentration associated with tetany and/or death. 3) Histological study of the grafted gland revealed normal architecture, and 4) Radioimmunoassay of extracted grafts revealed moderate to large quantities of parathyroid hormone.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001379:Azathioprine / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D002136:Calcium, Dietary; D004032:Diet; D004285:Dogs; D006650:Histocompatibility Testing; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D008722:Methods; D008775:Methylprednisolone / Q000494:pharmacology; D010280:Parathyroid Glands / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D010281:Parathyroid Hormone / Q000032:analysis; D010758:Phosphorus; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay; D013746:Tetany / Q000209:etiology; D014181:Transplantation Immunology; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D010758:Phosphorus; D001379:Azathioprine; D002118:Calcium; D008775:Methylprednisolone