Sensitivity to intravenous anaesthetics: a report of three cases.
Three patients with sensitivity to an intravenous anaesthetic-thiopentone, propanidid, and Althesin (alphadolone and alphaxalone)-are described. In the cases of thiopentone and Althesin the reaction was characterized by cardiovascular collapse, while bronchospasm also occurred with thiopentone. The reaction to propanidid was a direct skin sensitivity. All patients had a personal or family history of asthma and all had been previously exposed to the offending drug. A leucocyte challenge test showed an allergic response to thiopentone and Althesin in two patients but gave a negative result in the patient with the skin reaction. Allergic reactions can occur to all types of intravenous anaesthetics in a few patients.
D000328:Adult; D000628:Aminophylline / Q000627:therapeutic use; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001249:Asthma / Q000235:genetics; D001986:Bronchial Spasm / Q000139:chemically induced; D002245:Carbon Dioxide / Q000097:blood; D002319:Cardiovascular System / Q000187:drug effects; D002648:Child; D004338:Drug Combinations; D003875:Drug Eruptions; D004342:Drug Hypersensitivity; D004487:Edema; D006801:Humans; D006914:Hydroxysteroids / Q000009:adverse effects; D007073:Immunoglobulin E / Q000032:analysis; D007773:Lactates / Q000627:therapeutic use; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D010100:Oxygen / Q000097:blood; D011277:Pregnanediones / Q000009:adverse effects; D011410:Propanidid / Q000009:adverse effects; D012882:Skin Tests; D013874:Thiopental / Q000009:adverse effects
D004338:Drug Combinations; D006914:Hydroxysteroids; D007773:Lactates; D011277:Pregnanediones; D002245:Carbon Dioxide; D000628:Aminophylline; D007073:Immunoglobulin E; D011410:Propanidid; D013874:Thiopental; D010100:Oxygen