title: Ribosomal proteins involved in the suppression of streptomycin dependence in Escherichia coli.
abstract: Suppression of streptomycin dependence in Escherichia coli strain K-114, a spectinomycin-sensitive strain, is correlated with modification of 30S ribosomal protein P4, the component modified in spectinomycin-resistant mutants. The mutant is unusual in that reversion from dependence has previously been correlated only with modification in 30S protein P4a. Introduction into K-114 of another mutation conferring spectinomycin resistance results in a further alteration in protein P4.
mesh_terms: D000596:Amino Acids; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000032:analysis*; D002247:Carbon Isotopes; D002845:Chromatography; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000032:analysis / Q000187:drug effects* / Q000254:growth & development; D009154:Mutation; D012270:Ribosomes / Q000032:analysis*; D000198:Spectinomycin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology*; D014161:Transduction, Genetic; D014316:Tritium
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003470:Culture Media; D014316:Tritium; D000198:Spectinomycin; D013307:Streptomycin