Relationship between the structure and activity of antibiotics of the group of aureolic acid. Formation of complexes with DNA and suppression of RNA synthesis.
D000215:Acylation; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D002865:Chromomycins / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D008274:Magnesium / Q000494:pharmacology; D008968:Molecular Conformation; D009005:Monosaccharides / Q000378:metabolism; D009848:Olivomycins / Q000494:pharmacology; D008926:Plicamycin / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014500:Uracil Nucleotides / Q000378:metabolism
D002250:Carbon Radioisotopes; D002865:Chromomycins; D009005:Monosaccharides; D014500:Uracil Nucleotides; D009848:Olivomycins; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D008274:Magnesium; D008926:Plicamycin