title: DDT: disrupted osmoregulatory events in the intestine of the eel Anguilla rostrata adapted to seawater.
abstract: The drinking of seawater and absorption of water along with sodium across the intestinal epithelium are well-known osmoregulatory events in marine teleosts. The insecticide DDT impairs fluid absorption in intestinal sacs from eels adapted to seawater. Furthermore, this functional impairment has an enzymatic basis; DDT also inhibits the (Na(+) and K(+)) activated, Mg(2+)-dependent adenosine triphosphatase in homogenates of the intestinal mucosa. Thus, the extreme sensitivity of teleosts to organochlorine pollutants may involve the disruption of osmoregulatory transport mechanisms.
mesh_terms: D000251:Adenosine Triphosphatases / Q000032:analysis / Q000037:antagonists & inhibitors; D000818:Animals; D003634:DDT / Q000494:pharmacology*; D004524:Eels / Q000187:drug effects*; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D008274:Magnesium / Q000032:analysis; D011188:Potassium / Q000032:analysis; D012623:Seawater; D012964:Sodium / Q000032:analysis; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D012964:Sodium; D003634:DDT; D000251:Adenosine Triphosphatases; D008274:Magnesium; D011188:Potassium