Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
An orally active inhibitor of aldose reductase, 1,3-dioxo-1H-benz[de]-isoquinoline-2(3H)acetic acid (AY-22,284), prevented cataractous changes in cultured lenses exposed to high concentrations of galactose. When given orally, AY-22,284 markedly decreased the accumulation of polyols in the lenses and sciatic nerves of galactosemic rats and rats with streptozotocin-induced diabetes. In addition, treatment of galactosemic rats with AY-22,284 effectively suppressed the formation of cataracts.
D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology; D000284:Administration, Oral; D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D046508:Culture Techniques; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000517:prevention & control; D005632:Fructose / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D005693:Galactosemias / Q000150:complications* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000378:metabolism; D051381:Rats; D012584:Sciatic Nerve / Q000378:metabolism; D013012:Sorbitol / Q000378:metabolism; D013311:Streptozocin; D013402:Sugar Alcohols / Q000378:metabolism*
D000085:Acetates; D007546:Isoquinolines; D013402:Sugar Alcohols; D005632:Fructose; D013012:Sorbitol; D013311:Streptozocin; D000429:Alcohol Oxidoreductases; D005947:Glucose; D005690:Galactose