title: R62, a naturally occurring hybrid R plasmid.
abstract: R62, a naturally occurring R factor, was shown to be a single deoxyribonucleic acid molecule composed of polynucleotide sequences typical of I group plasmids and also sequences typical of the N group. It determined I pili and belonged to the Ialpha compatibility group. Although compatible with plasmids of group N, R62 showed complex genetic reactions with N plasmids which are described and interpreted. It is concluded that R62 was the product of illegitimate recombination between an I group and an N group plasmid.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002250:Carbon Radioisotopes; D002499:Centrifugation, Density Gradient; D003087:Colicins / Q000096:biosynthesis; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000032:analysis*; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005111:Extrachromosomal Inheritance; D008970:Molecular Weight; D010403:Penicillin Resistance; D011119:Polynucleotides / Q000032:analysis; D011995:Recombination, Genetic; D000198:Spectinomycin / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013941:Thymine; D014161:Transduction, Genetic; D014316:Tritium
chemical_list: D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D003087:Colicins; D004269:DNA, Bacterial; D011119:Polynucleotides; D013449:Sulfonamides; D014316:Tritium; D000667:Ampicillin; D000198:Spectinomycin; D013752:Tetracycline; D013941:Thymine; D013307:Streptomycin