Bovine viral diarrhea virus in swine: characteristics of virus recovered from naturally and experimentally infected swine.
A noncytopathogenic field strain of bovine viral diarrhea virus (BVDV) was isolated from an Iowa farm brood sow and from her hysterectomy-derived, colostrum-deprived (HDCD) piglets. This field isolant was fully virulent for a neonatal calf. The NADL strain of BVDV was passaged through a series of HDCD piglets with no resultant loss of virulence for neonatal calves. Most of the BVD viral isolants recovered from pigs had been changed from a cytopathogenic biotype to a noncytopathogenic biotype. Circumstantial evidence points to swine as "carrier" hosts of BVDV.
D000818:Animals; D000831:Animals, Newborn; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000209:etiology; D002417:Cattle; D002418:Cattle Diseases; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004622:Embryo, Mammalian; D005243:Feces / Q000382:microbiology; D005260:Female; D005455:Fluorescent Antibody Technique; D005856:Germ-Free Life; D007044:Hysterectomy; D007668:Kidney; D007962:Leukocytes / Q000382:microbiology; D009500:Neutralization Tests; D012328:RNA Viruses / Q000276:immunology / Q000302:isolation & purification*; D013154:Spleen / Q000382:microbiology; D013552:Swine; D013553:Swine Diseases / Q000209:etiology / Q000382:microbiology*; D014774:Virulence; D014776:Virus Cultivation; D014777:Virus Diseases / Q000382:microbiology / Q000662:veterinary*