Carcinoid myopathy and treatment with cyproheptadine (Periactin).
A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT). Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.
D000135:Acid Phosphatase / Q000032:analysis; D003533:Cyproheptadine / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy; D005243:Feces; D005260:Female; D010134:Fenclonine / Q000627:therapeutic use; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008303:Malignant Carcinoid Syndrome / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D009210:Myofibrils
D003533:Cyproheptadine; D006897:Hydroxyindoleacetic Acid; D000135:Acid Phosphatase; D010134:Fenclonine