25-Hydroxycholecalciferol: stimulation of bone resorption in tissue culture.
25-Hydroxycholecalciferol stimulates release of previously incorporated calcium-45 from fetal rat bones in doses of 0.9 to 27 units per milliliter. This effect cannot be produced by much larger doses of vitamin D(3). Comparison of stimulation of bone resorption by 25-hydroxycholecalciferol and parathyroid hormone reveals similarities with respect to time course, dose-response slope, and inhibition by calcitonin.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000196:embryology; D002116:Calcitonin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002127:Calcium Isotopes; D002762:Cholecalciferol / Q000008:administration & dosage / Q000494:pharmacology*; D046508:Culture Techniques; D005333:Fetus; D010281:Parathyroid Hormone / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D002127:Calcium Isotopes; D010281:Parathyroid Hormone; D002762:Cholecalciferol; D002116:Calcitonin; D002118:Calcium