Titration patterns of a murine sarcoma-leukemia virus complex: evidence for existence of competent sarcoma virions.
Stocks of inurine sarcoma virus show titration patterns ranging from one-to two-hit kinetics. The comparison of various titrations of this virus, both with and without added helper virus, to theoretical model systems composed of defined constituents, suggests the existence of a sarcoma virus that does not need coinfectinig murine leukemia virus to be manifested as a focus-forming unit. The behavior of such nondefective particles is compatible with a postulated leukemia-sarcoma virus hybrid.
D000818:Animals; D046508:Culture Techniques; D003673:Defective Viruses; D005827:Genetics, Microbial; D006378:Helper Viruses; D007700:Kinetics; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D051379:Mice; D008954:Models, Biological; D008979:Moloney murine leukemia virus / Q000472:pathogenicity*; D012367:RNA, Viral; D011925:Rauscher Virus; D012513:Sarcoma, Experimental; D014764:Viral Proteins
D012367:RNA, Viral; D014764:Viral Proteins