title: Viral neoplastic transformation of hamster prostate tissue in vitro.
abstract: Cultures of hamster prostatic tissues infected with simian virus 40 undergo transformation in vitro, and the transformed cells produce malignant tumors when injected into homologous hosts. Tartrate-inhibited acid phosphastase is found in the cultures of transformed cells and in the tumors they produce. Tartrate-inhibited acid phosphatase activity is elevated in the serum of tumor-bearing animals.
mesh_terms: D000135:Acid Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D013539:Simian virus 40 / Q000472:pathogenicity*; D013644:Tartrates
chemical_list: D013644:Tartrates; D000135:Acid Phosphatase