The inhibition of enzymes by beryllium.
1. The action of beryllium on the following enzymes has been examined: alkaline phosphatase (Escherichia coli and kidney), acid phosphatase, phosphoprotein phosphatase, apyrase (potato), adenosine triphosphatase (liver nuclei, liver mitochondria, brain microsomes), glucose 6-phosphatase, polysaccharide phosphorylases a and b, phosphoglucomutase, hexokinase, phosphoglyceromutase, ribonuclease, A-esterase (rabbit serum), cholinesterase (horse serum), chymotrypsin. Alkaline phosphatase and phosphoglucomutase are inhibited by 1mum-beryllium sulphate whereas the other enzymes are largely unaffected by 1mm-beryllium sulphate. 2. Possible mechanisms for the inhibition of phosphoglucomutase and alkaline phosphatase are discussed.
D000135:Acid Phosphatase / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D001608:Beryllium; D002802:Cholinesterases / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism*; D004798:Enzymes; D004926:Escherichia coli / Q000201:enzymology; D004950:Esterases / Q000378:metabolism*; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D005964:Glucosyltransferases / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D010733:Phosphoglucomutase / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism*
D004798:Enzymes; D005964:Glucosyltransferases; D010770:Phosphotransferases; D006593:Hexokinase; D004950:Esterases; D012260:Ribonucleases; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D005952:Glucose-6-Phosphatase; D002918:Chymotrypsin; D000251:Adenosine Triphosphatases; D010733:Phosphoglucomutase; D001608:Beryllium