Reactivity of plasmalogens: kinetics of acid-catalyzed hydrolysis.
The acid-catalyzed hydrolysis of the alpha,-unsaturated ether group of two plasmalogens, lysophosphatidal choline and lysophosphatidal ethanolamine, and several model compounds (isobutyl vinyl ether, 1-butenyl ethyl ether, and dihydropyran) was studied by determining the true second-order rate constants. The results indicate that the chemical reactivity of the substituted vinyl ether group in plasmalogens is not appreciably affected by the presence of a bulky substituent on the -carbon. Activation energies, enthalpies, and entropies were also determined (from measurements of the rate constants at different temperatures).
D055598:Chemical Phenomena; D002621:Chemistry; D004987:Ethers; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008244:Lysophosphatidylcholines; D010472:Perchlorates; D010955:Plasmalogens; D011714:Pyrans; D013696:Temperature; D013816:Thermodynamics
D004987:Ethers; D008244:Lysophosphatidylcholines; D010472:Perchlorates; D010955:Plasmalogens; D011714:Pyrans