Effect of rabbit antibodies against angiotensin-II on the pressor response to angiotensin-II and renal hypertension in the rat.
1. In the intact or nephrectomized rat, the pressor responses to synthetic angiotensin-II-amide, beta-angiotensin-II and native "rat angiotensin" could be inhibited by intravenous injection of rabbit serum containing antibodies against synthetic angiotensin-II-amide.2. The pressor responses to vasopressin or noradrenaline were not influenced by anti-angiotensin serum.3. A single injection of anti-angiotensin serum inhibited the pressor responses to angiotensin-II-amide for a period of 2.5 hr.4. Intravenous infusion or daily intraperitoneal injection of anti-angiotensin serum did not influence blood pressure levels in renal hypertensive rats.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies; D001794:Blood Pressure / Q000187:drug effects; D006977:Hypertension, Renal / Q000188:drug therapy*; D007106:Immune Sera / Q000494:pharmacology; D007267:Injections; D009392:Nephrectomy; D009638:Norepinephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology
D000906:Antibodies; D007106:Immune Sera; D014667:Vasopressins; D000804:Angiotensin II; D009638:Norepinephrine