Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol.
Mannitol is dissimilated by Aerobacter aerogenes via an inducible pathway initiated by a phosphotransferase system dependent upon phosphoenolpyruvate as the phosphoryl donor. A mutational block in this pathway can be suppressed either at the phenotypic level by induction of d-arabitol dehydrogenase, an enzyme fortuitously capable of converting mannitol to fructose, or genotypically by a constitutive mutation in the d-arabitol system.
D004754:Enterobacter / Q000201:enzymology / Q000378:metabolism*; D004790:Enzyme Induction; D004794:Enzyme Repression; D008353:Mannitol / Q000378:metabolism*; D009154:Mutation; D009243:NAD; D010088:Oxidoreductases / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism
D011773:Pyruvates; D009243:NAD; D008353:Mannitol; D010088:Oxidoreductases; D010770:Phosphotransferases