Histone phosphorylation: stimulation by adenosine 3',5'-monophosphate.
Adenosine cyclic 3',5'-monophosphate at a concentration of 10-(7)M causes a four-to sixfold increase in the rate of histone phosphorylation catalyzed by a liver enzyme preparation. This observation suggests a mechanism for the induction of RNA synthesis by those hormones that cause increases in the concentration of cyclic AMP.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D006657:Histones / Q000378:metabolism*; D006728:Hormones / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000201:enzymology; D010710:Phosphates / Q000378:metabolism*; D010759:Phosphorus Isotopes; D010770:Phosphotransferases / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D013268:Stimulation, Chemical
D000227:Adenine Nucleotides; D006657:Histones; D006728:Hormones; D010710:Phosphates; D010759:Phosphorus Isotopes; D012313:RNA; D000242:Cyclic AMP; D010770:Phosphotransferases