Steroid hormones: effects on adenyl cyclase activity and adenosine 3',5'-momophosphate in target tissues.
The adenyl cyclases of chick oviduct and rat prostate were not stimulated by estrogen and testosterone, respectively, suggesting that growth and differentiation of these target tissues are not mediated by adenosine 3',5'-monophosphate. Estrogen acutely activated adenyl cyclase in the castrate rat uterus, but this was prevented by administration of DL-propranolol, suggesting that the effect was mediated by catecholamines. Progesterone produced a delayed stimulation of oviduct adenyl cyclase preceding and concomitant with the induction of synthesis of avidin.
D000227:Adenine Nucleotides; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002369:Castration; D002645:Chickens; D000242:Cyclic AMP; D004054:Diethylstilbestrol / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004798:Enzymes / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008297:Male; D010057:Oviducts / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D014599:Uterus / Q000201:enzymology
D000227:Adenine Nucleotides; D004798:Enzymes; D012739:Gonadal Steroid Hormones; D013739:Testosterone; D011374:Progesterone; D004054:Diethylstilbestrol; D011433:Propranolol; D000242:Cyclic AMP; D000262:Adenylyl Cyclases