The effect of chlorpromazine on cerebral glucose, ATP, ADP, AMP and ATPase in the mouse.
1. Administration of chlorpromazine 10 mg/kg intraperitoneally to mice produced no alteration in cerebral adenosine triphosphate (ATP), adenosine diphosphate (ADP) or adenosine monophosphate (AMP). In these animals there was an increase in the glucose content of the supernatants of homogenates of liver and brain following acid hydrolysis.2. Chlorpromazine 40 mg/kg intraperitoneally did not affect Mg(++) activated adenosine triphosphatase (ATPase) activity in the brain.
D000227:Adenine Nucleotides / Q000032:analysis*; D000251:Adenosine Triphosphatases / Q000032:analysis* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D000242:Cyclic AMP / Q000032:analysis; D005260:Female; D005947:Glucose / Q000032:analysis*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000032:analysis; D008274:Magnesium; D008297:Male; D051379:Mice
D000227:Adenine Nucleotides; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D000251:Adenosine Triphosphatases; D008274:Magnesium; D005947:Glucose; D002746:Chlorpromazine