Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide.
This paper describes the experimental and clinical findings of acrylamide intoxication in a human being. It is believed that this is the first such case to be recorded in the medical literature.Acrylamide is widely used as a "chemical grout". It is pumped into dirt, clay and stone walls of excavations in a liquid state together with a catalyst, and it then polymerizes to make a watertight shield.This chemical is neurotoxic in its non-polymerized form and can be absorbed through the intact skin, mucous membranes and lungs. In spite of warnings with regard to its handling, this worker became careless, and developed a contact dermatitis and a polyneuropathy with bluish cold extremities which dripped perspiration.In six months' time after his removal from contact with the chemical the patient made a complete clinical recovery. He was advised not to work with the chemical.
D000180:Acrylic Resins / Q000009:adverse effects*; D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D012869:Skin Absorption; D013564:Sympathetic Nervous System / Q000187:drug effects
D000180:Acrylic Resins