title: Pituitary tumors in mice after prolonged feeding of synthetic progestins.
abstract: An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.
mesh_terms: D000818:Animals; D001681:Biological Assay; D006528:Carcinoma, Hepatocellular; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D008113:Liver Neoplasms; D051379:Mice; D009640:Norethindrone / Q000494:pharmacology*; D009641:Norethynodrel / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000209:etiology*
chemical_list: D004997:Ethinyl Estradiol; D009641:Norethynodrel; D009640:Norethindrone