Virus-specific nucleic acids in SV40-exposed hamster embryo cell lines: correlation with S and T antigens.
A number of homologous SV40-exposed hamster embryonic cell lines were examined for the presence of RNA complementary to SV40 DNA. Only those lines containing the SV40 T antigen were found to have such virus-specific RNA. In lines containing the SV40 S antigen, but not the SV40 T antigen, virus-specific RNA was not detected. These findings suggest that the S antigen is not coded for directly by the SV40 genome.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D046508:Culture Techniques; D004279:DNA, Viral; D004622:Embryo, Mammalian; D006824:Hybridization, Genetic; D009374:Neoplasms, Experimental / Q000276:immunology*; D012367:RNA, Viral / Q000032:analysis*; D013539:Simian virus 40; D014316:Tritium
D000941:Antigens; D004279:DNA, Viral; D012367:RNA, Viral; D014316:Tritium