Bacterial metabolism of mevalonic acid.
Soluble cell-free extracts of actinomycete S4 grown on media containing mevalonate catalyze acetoacetate formation from mevalonate, mevaldate, and beta-hydroxy-beta-methylglutaryl-coenzyme A (CoA). Conversion of mevalonate to acetoacetate involves formation of free beta-hydroxy-beta-methylglutaryl-CoA, but not free mevaldate. The reaction favors mevalonate oxidation, and nicotinamide adenine dinucleotide, rather than nicotinamide adenine dinucleotide phosphate, acts as oxidant.
D000090:Acetoacetates / Q000378:metabolism*; D000143:Acids / Q000378:metabolism; D000192:Actinomycetales / Q000378:metabolism*; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008798:Mevalonic Acid / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology; D010101:Oxygen Consumption
D000090:Acetoacetates; D000143:Acids; D002247:Carbon Isotopes; D007656:Ketoglutaric Acids; D009243:NAD; D008798:Mevalonic Acid