Mengovirus-induced cytopathic effect in L-cells: protective effect of interferon.
The effect of interferon on mengovirus-induced cytopathic effect (CPE) in L cells, the cut-off of host-cell protein synthesis, and production of mature virus were found to be dependent on the concentration of interferon. CPE and inhibition of host protein synthesis were not affected until the concentration of interferon was increased 100-fold over that required to reduce viral yields by 90%.
D000818:Animals; D002247:Carbon Isotopes; D003513:Cycloheximide / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D004686:Encephalomyocarditis virus / Q000254:growth & development / Q000472:pathogenicity*; D066298:In Vitro Techniques; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects; D008247:Lysosomes / Q000503:physiopathology; D051379:Mice; D014176:Protein Biosynthesis; D014633:Valine; D014762:Viral Interference
D002247:Carbon Isotopes; D007372:Interferons; D003513:Cycloheximide; D014633:Valine