title: Lipid abnormalities in foam cell reticulosis of mice, an analogue of human sphingomyelin lipidosis.
abstract: The lipid changes in the inheritable foam cell reticulosis of mice discovered by Lyons, Hulse, and Rowe have been reexamined. The major abnormality in thymuses from homozygous-abnormal animals has been identified as an increase in the concentration (per milligram of protein) of sphingomyelin and cholesterol. This increase is associated with normal sphingomyelin-cleaving activity. The lipid compositions of the liver and spleen in the homozygous-abnormal animal and of the thymus in the heterozygous-abnormal mouse are normal. The disorder appears to be chemically analogous to those forms of human sphingomyelin lipidosis (Niemann-Pick disease) that are not accompanied by a decrease in tissue sphingomyelinase.
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D002784:Cholesterol / Q000378:metabolism; D002855:Chromatography, Thin Layer; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008206:Lymphatic Diseases; D008244:Lysophosphatidylcholines / Q000378:metabolism; D051379:Mice; D009542:Niemann-Pick Diseases; D010641:Phenotype; D010713:Phosphatidylcholines / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism*; D013154:Spleen / Q000201:enzymology / Q000378:metabolism*; D013950:Thymus Gland / Q000201:enzymology / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D008074:Lipoproteins; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010743:Phospholipids; D013109:Sphingomyelins; D002784:Cholesterol; D010740:Phospholipases