Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000378:metabolism*; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D002474:Cell-Free System; D002499:Centrifugation, Density Gradient; D002794:Choline / Q000378:metabolism*; D046508:Culture Techniques; D003864:Depression, Chemical; D004176:Dipyridamole / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008113:Liver Neoplasms / Q000201:enzymology / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000378:metabolism; D009711:Nucleotides / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010770:Phosphotransferases; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014316:Tritium; D014500:Uracil Nucleotides / Q000096:biosynthesis; D014529:Uridine / Q000378:metabolism*
D009711:Nucleotides; D010710:Phosphates; D010713:Phosphatidylcholines; D014500:Uracil Nucleotides; D014316:Tritium; D000431:Ethanol; D012313:RNA; D004176:Dipyridamole; D010770:Phosphotransferases; D002794:Choline; D014529:Uridine