Detection of viruslike particles in germ-free mice.
Kajima, Masahiro (University of Notre Dame, Notre Dame, Ind.), and Morris Pollard. Detection of viruslike particles in germ-free mice. J. Bacteriol. 90:1448-1454. 1965.-Viruslike particles similar in structure to the mouse leukemia agent were detected by electron microscopy in thymus tissues of germ-free AK mice which had developed spontaneous leukemia. In addition, unique viruslike particles (type B) were detected in tissues from spontaneous mammary adenocarcinoma of germ-free C3H mice. Leukemia virus-like particles were also observed in the thymuses of the control AK mice and of the C3H control mice as well as of those with mammary tumors. Germ-free mice are not virus-free. The routes of transmission of leukemia as well as of mammary tumor viruses may be "vertical," through the embryo or placenta.
D000818:Animals; D005856:Germ-Free Life; D066298:In Vitro Techniques; D009052:Leukemia Virus, Murine / Q000166:cytology*; D008324:Mammary Tumor Virus, Mouse / Q000166:cytology*; D051379:Mice; D008854:Microscopy, Electron; D013950:Thymus Gland / Q000166:cytology*