Interaction of polypeptide hormones with lipid monolayers.
1. The interaction between lipid monolayers spread on the surface of water and oxytocin, [8-arginine]-vasotocin and [1-asparagine-5-valine]-angiotensin II in the subphase was investigated in a Langmuir surface trough by studying the changes in pressure produced on injection of various quantities of the polypeptide solution under the film. 2. The effect of 2m- and 4m-urea on the character of the adsorption is reported. 3. Structures for the adsorbed films formed in this way are suggested. 4. If the lipid monolayer is taken as a suitable model of cell membranes, then it may be supposed that the effect of such structures forming in cell membranes would be to provide effective ;pores' to facilitate the movement of water and other small molecules across the membrane.
D000327:Adsorption; D000804:Angiotensin II; D002462:Cell Membrane; D055598:Chemical Phenomena; D002621:Chemistry; D006728:Hormones; D008055:Lipids; D008956:Models, Chemical; D010121:Oxytocin; D010455:Peptides; D013229:Stearic Acids; D014508:Urea; D014668:Vasotocin
D006728:Hormones; D008055:Lipids; D010455:Peptides; D013229:Stearic Acids; D000804:Angiotensin II; D010121:Oxytocin; D014508:Urea; D014668:Vasotocin