Production of interferon by alveolar macrophages.
Acton, Jean D. (Bowman Gray School of Medicine, Winston-Salem, N.C.), and Quentin N. Myrvik. Production of interferon by alveolar macrophages. J. Bacteriol. 91:2300-2304. 1966.-Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable at pH 4, is not sedimented at 100,000 x g, exhibits species specificity, and can passively protect other alveolar macrophages from infection with virulent rabbitpox virus. The possible significance of alveolar macrophage-produced interferon is discussed.
D000818:Animals; D001681:Biological Assay; D046508:Culture Techniques; D006863:Hydrogen-Ion Concentration; D007372:Interferons / Q000096:biosynthesis*; D008264:Macrophages / Q000378:metabolism*; D011212:Poxviridae / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000166:cytology*; D011817:Rabbits; D018108:Respirovirus / Q000276:immunology; D013045:Species Specificity
D007372:Interferons