Generation of adrenergic and cholinergic potentials in sympathetic ganglion cells.
Norepinephrine elicited a hyperpolarizing response, and acetylcholine (during nicotinic blockade) elicited a depolarizing one. Both responses showed no increase in membrane conductance. The norepinephrine response was suppressed by initial depolarization; the acetylcholine response (frog cells); by hyperpolarization. These neurotransmitters apparently can activate electrogenic mechanisms which do not involve movement of ions down their electrochemical gradients.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001665:Binding Sites; D005725:Ganglia, Autonomic / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D010042:Ouabain / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D011817:Rabbits; D009435:Synaptic Transmission; D014403:Tubocurarine / Q000494:pharmacology
D010042:Ouabain; D009538:Nicotine; D010830:Physostigmine; D000109:Acetylcholine; D014403:Tubocurarine; D009638:Norepinephrine