title: Quantal secretion from adrenal medulla: all-or-none release of storage vesicle content.
abstract: Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-beta-hydroxylase activity and the catecholamine content of the storage vesicle fraction. After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-beta-hydroxylase to catecholamine as did vesicles from untreated animals. These and other data indicate that neurogenic secretion from the adrenal medulla occurs by an all-or-none release from the storage vesicles.
mesh_terms: D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000032:analysis; D002499:Centrifugation, Density Gradient; D004298:Dopamine / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000032:analysis; D008959:Models, Neurological; D009489:Neurosecretion / Q000187:drug effects*; D011789:Quantum Theory; D011817:Rabbits; D009435:Synaptic Transmission
chemical_list: D002395:Catecholamines; D007328:Insulin; D006899:Mixed Function Oxygenases; D004298:Dopamine