Formation of virus-like particles by bone cells in mice with a high incidence of spontaneous leukemia.
Bone samples from potentially leukemic and leukemic mice revealed numerous 90-to 110-nanometer particles morphologically identical to murine leukemia virus. Particles were observed budding from plasma membranes of osteocytes and osteoblasts but were most numerous in osteocyte lacunae. Particles were not observed in bone samples from mice which rarely develop leukemia.
D000818:Animals; D001842:Bone and Bones / Q000382:microbiology*; D009052:Leukemia Virus, Murine / Q000302:isolation & purification*; D007945:Leukemia, Lymphoid / Q000235:genetics*; D051379:Mice; D008854:Microscopy, Electron