Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid.
There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.
D066298:In Vitro Techniques; D007538:Isoniazid / Q000494:pharmacology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism*; D009243:NAD / Q000096:biosynthesis*; D009708:Nucleotidases / Q000378:metabolism*
D009243:NAD; D009708:Nucleotidases; D007538:Isoniazid