Differences in the transfer RNA's of normal liver and Novikoff hepatoma.
-A comparison of the elution profiles of 18 aminoacyl-tRNA's from Novikoff hepatoma with those from normal liver on a methylated albuminkieselguhr column revealed the occurrence of new species of tRNA for histidine, tyrosine, and asparagine in the hepatoma. In addition, the hepatoma tRNA's for arginine, isoleucine, lysine, methionine, serine, alanine, and tryptophan eluted at a higher salt concentration than the corresponding tRNA's of normal liver. The remaining eight amino acids did not show any significant differences in the elution profiles.
D000596:Amino Acids; D000818:Animals; D001216:Asparagine; D002247:Carbon Isotopes; D006528:Carcinoma, Hepatocellular; D002845:Chromatography; D006639:Histidine; D008025:Ligases; D008099:Liver / Q000032:analysis*; D008113:Liver Neoplasms; D008722:Methods; D009374:Neoplasms, Experimental; D012343:RNA, Transfer / Q000032:analysis*; D051381:Rats; D014316:Tritium; D014443:Tyrosine
D000596:Amino Acids; D002247:Carbon Isotopes; D014316:Tritium; D014443:Tyrosine; D006639:Histidine; D001216:Asparagine; D012343:RNA, Transfer; D008025:Ligases