Radical transformation in irradiated DNA and its constituents.
Electron spin resonance spectroscopy has been used to study transformation of radicals in DNA and a number of its constituents. It was found that in all the bases irradiated at 77 degrees K, hydrogen-addition radicals were formed on warming. The following mechanism of radical transformation has been proposed: damaged species, probably ion-radicals, release hydrogen atoms on warming, which then add to the undamaged bases, preferentially thymine. Thymine need not be the place of the primary damage.
D003036:Cobalt Isotopes; D004247:DNA / Q000528:radiation effects*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D011830:Radiation Effects; D013696:Temperature
D003036:Cobalt Isotopes; D005609:Free Radicals; D004247:DNA