title: Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii).
abstract: Chick and mouse cell monolayers treated with interferon were significantly protected from destruction by toxoplasma. The results suggest that fewer numbers of organisms were released from interferon-treated cells. Interferons were uniformly more active in a viral assay than in a toxoplasma assay, and they had the same properties in both assays. The data suggest that interferon activity may be directed against organisms phylogenetically higher than viruses.
mesh_terms: D000818:Animals; D002642:Chick Embryo / Q000166:cytology; D003470:Culture Media; D046508:Culture Techniques; D005347:Fibroblasts / Q000382:microbiology; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D014122:Toxoplasma / Q000472:pathogenicity*; D014721:Vesicular stomatitis Indiana virus; D014774:Virulence
chemical_list: D003470:Culture Media; D012333:RNA, Messenger; D012367:RNA, Viral; D007372:Interferons