The effect of an interferon inducer on influenza virus.
The double-stranded complex of polyriboinosinic acid and polyribocytidilic acid (poly I.poly C) was shown to inhibit effectively the infection of human cells with 4 common human respiratory pathogens-influenza A2, rhinovirus 13, respiratory syncytial and parainfluenza-1 viruses. This protection was observed with levels of poly I.poly C which did not induce the release of detectable amounts of interferon. Mice could be protected from pulmonary influenza A2 infections by intranasal instillation of poly I.poly C before challenge with virus. Administration of poly I.poly C directly to the respiratory tract was found superior to systemic administration in the case of the pulmonary infection studied.
D000818:Animals; D046508:Culture Techniques; D003597:Cytosine Nucleotides / Q000494:pharmacology*; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D009705:Nucleosides / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000187:drug effects*; D011119:Polynucleotides / Q000494:pharmacology*; D012229:Rhinovirus / Q000187:drug effects
D003597:Cytosine Nucleotides; D009705:Nucleosides; D011119:Polynucleotides; D007372:Interferons