Inhibition of cell growth in vitro by adenosine 3',5'-monophosphate.
Adenosine 3',5'-monophosphate, at a concentration of 40 micrograms per milliliter, inhibits the growth of HeLa and strain L cells in culture. The inhibition becomes progressively greater during the incubation of the cells. Adenosine 5'-monophosphate and adenosine, metabolites of adenosine 3',5'-monophosphate, do not affect the growth of either cell culture. This suggests that 3',5'-monophosphate enters the cell without alteration. Dibutyryl-adenosine 3',5'-monophosphate, reported to have a greater activity than adenosine 3'5'-monophosphate on several tissues, inhibited the growth of the cells much less.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D003864:Depression, Chemical; D006367:HeLa Cells / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D066298:In Vitro Techniques; D007739:L Cells
D000227:Adenine Nucleotides; D000242:Cyclic AMP