Regulation of the adrenal cortex secretory pattern by adrenocorticotropin.
Adrenal gland homogenates from rabbits stimulated for 28 days with adrenocorticotropin have been shown to synthesize cortisol. The total amount of cortisol formed was the same whether progesterone-4-(14)C or Delta(5)-pregnenolone-4-(14)C was used as exogenous substrate. However, when Delta(5)-pregnenolone substrate was used the specific activity of the isolated cortisol was four times as great as when progesterone was used.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D003345:Corticosterone / Q000096:biosynthesis* / Q000302:isolation & purification; D003900:Desoxycorticosterone / Q000096:biosynthesis* / Q000302:isolation & purification; D006854:Hydrocortisone / Q000096:biosynthesis* / Q000302:isolation & purification; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010913:Pituitary-Adrenal System; D011284:Pregnenolone / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011817:Rabbits; D013268:Stimulation, Chemical
D002247:Carbon Isotopes; D003900:Desoxycorticosterone; D011374:Progesterone; D011284:Pregnenolone; D000324:Adrenocorticotropic Hormone; D006899:Mixed Function Oxygenases; D003345:Corticosterone; D006854:Hydrocortisone