title: SV40-specific RNA in the nucleus and polyribosomes of transformed cells.
abstract: Cells transformed by the oncogenic virus SV40 are known to contain viral DNA integrated into cellular DNA and to produce virus-specific RNA. It has been shown that nuclear molecules containing virus-specific sequences are considerably longer than presumed virus-specific mRNA molecules from cytoplasmic polyribosomes. This finding suggests the possibility that cytoplasmic mRNA is derived by the specific cleavage of larger nuclear RNA.
mesh_terms: D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D002501:Centrifugation, Zonal; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral; D004622:Embryo, Mammalian / Q000166:cytology; D006824:Hybridization, Genetic; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*; D013539:Simian virus 40
chemical_list: D004279:DNA, Viral; D012333:RNA, Messenger; D012367:RNA, Viral