Vitamin D3-stimulated template activity of chromatin from rat intestine.
Administration of vitamin D to rats deficient in this vitamin markedly increases the template activity for DNA-dependent RNA synthesis by rat intestinal mucosal chromatin. The maximum stimulation of template activity occurs three hours after a dose of 2000 international units of vitamin D(3) is given. These results support the concept that vitamin D functions by initiating the transcription of DNA into mRNA, which codes for functional protein(s) involved in calcium transport in the small intestine.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes; D002762:Cholecalciferol / Q000494:pharmacology*; D004247:DNA; D005815:Genetic Code; D007413:Intestinal Mucosa / Q000187:drug effects*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D012728:Sex Chromatin / Q000187:drug effects; D013698:Templates, Genetic / Q000187:drug effects*
D002247:Carbon Isotopes; D012333:RNA, Messenger; D002762:Cholecalciferol; D000255:Adenosine Triphosphate; D004247:DNA