title: Brain alcohol dehydrogenase.
abstract: Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D000431:Ethanol / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009422:Nervous System Diseases / Q000209:etiology; D011409:Propylene Glycols / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D013440:Sulfides / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D002247:Carbon Isotopes; D011409:Propylene Glycols; D011720:Pyrazoles; D013440:Sulfides; D009243:NAD; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D000079:Acetaldehyde