Prostaglandin stimulation of rat corticosteroidogenesis.
Prostaglandins and their C20:(omega)6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE(1), PGE(2), or PGF(1infinity) 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3', 5'-cyclic monophosphate; all three responses were inhibited by cycloheximide.
D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D003345:Corticosterone / Q000096:biosynthesis; D000242:Cyclic AMP / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005260:Female; D007016:Hypophysectomy; D066298:In Vitro Techniques; D010902:Pituitary Gland / Q000502:physiology; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats
D000305:Adrenal Cortex Hormones; D011453:Prostaglandins; D000324:Adrenocorticotropic Hormone; D003513:Cycloheximide; D000242:Cyclic AMP; D003345:Corticosterone