On the mechanism of action of adrenocorticotropic hormone: the binding of cyclic-3',5'-adenosine monophosphate to an adrenal cortical protein.
The binding of cyclic 3',5'-adenosine monophosphate (cyclic AMP) within the adrenal cortical cell was studied. Cyclic AMP binds specifically to a protein which is associated predominantly with the microsomal fraction of the cell. The binding protein was purified approximately 100-fold.
D000227:Adenine Nucleotides; D000305:Adrenal Cortex Hormones; D000311:Adrenal Glands / Q000166:cytology; D001665:Binding Sites; D002499:Centrifugation, Density Gradient; D011232:Chemical Precipitation; D002845:Chromatography; D000242:Cyclic AMP; D003593:Cytoplasm; D003956:Dialysis; D008861:Microsomes; D011485:Protein Binding; D014316:Tritium
D000227:Adenine Nucleotides; D000305:Adrenal Cortex Hormones; D014316:Tritium; D000242:Cyclic AMP