Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids).
Synthetic 2-stranded RNA-a helical complex formed by duplexing homopolymers of polyriboinosinic and polyribocytidylic acids (poly I:C)-induced host resistance to foot-and-mouth disease virus when microgram quantities were injected into mice. There was a graded response as shown by titrations of polynucleotide complex or virus. Protection was effective for >48 hours after a single injection of polynucleotide complex. Survival and serum interferon titers were directly related.
D000818:Animals; D005537:Aphthovirus / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000097:blood; D051379:Mice; D011119:Polynucleotides / Q000494:pharmacology*; D012313:RNA / Q000138:chemical synthesis* / Q000494:pharmacology; D014762:Viral Interference / Q000187:drug effects*
D011119:Polynucleotides; D012313:RNA; D007372:Interferons