Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids).
Two-stranded polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids protect against herpes simplex virus-induced cytopathogenicity in HEp 2 cultures, systemic herpes simplex virus infection in mice, and herpes simplex virus-induced keratoconjunctivitis in rabbits.
D000818:Animals; D002277:Carcinoma; D002460:Cell Line; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D003597:Cytosine Nucleotides / Q000494:pharmacology* / Q000627:therapeutic use; D003864:Depression, Chemical; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D006801:Humans; D007637:Keratoconjunctivitis / Q000188:drug therapy; D007822:Laryngeal Neoplasms; D008297:Male; D051379:Mice; D011119:Polynucleotides / Q000494:pharmacology* / Q000627:therapeutic use; D012313:RNA / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D018139:Simplexvirus / Q000187:drug effects*; D014500:Uracil Nucleotides / Q000494:pharmacology* / Q000627:therapeutic use
D003597:Cytosine Nucleotides; D011119:Polynucleotides; D014500:Uracil Nucleotides; D012313:RNA