Inactivation of viruses by benzalkonium chloride.
Benzalkonium chloride (as Roccal or Zephiran) was found to inactivate influenza, measles, canine distemper, rabies, fowl laryngotracheitis, vaccinia, Semliki Forest, feline pneumonitis, meningopneumonitis, and herpes simplex viruses after 10 min of exposure at 30 C or at room temperature. Poliovirus and encephalomyocarditis virus were not inactivated under the same conditions. It was concluded that all viruses tested were sensitive except members of the picorna group. The literature was reviewed.
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002689:Chlamydia / Q000187:drug effects*; D004217:Distemper Virus, Canine / Q000187:drug effects*; D004285:Dogs; D004686:Encephalomyocarditis virus / Q000187:drug effects*; D006507:Hepatovirus / Q000187:drug effects*; D006564:Herpesviridae / Q000187:drug effects*; D008459:Measles virus / Q000187:drug effects*; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D017955:Poliovirus / Q000187:drug effects*; D011820:Rabies virus / Q000187:drug effects*; D012672:Semliki forest virus / Q000187:drug effects*; D014616:Vaccinia virus / Q000187:drug effects*
D000891:Anti-Infective Agents, Local