Specific inhibition of viral ribonucleic acid replication by Gliotoxin.
Gliotoxin inhibits intracellular replication of poliovirus in HeLa cells at a stage subsequent to adsorption and penetration of virus. The sensitive step is synthesis of viral RNA: synthesis of viral protein is unaffected except as a consequence of blockade of RNA synthesis. Concentrations of gliotoxin sufficient to block viral RNA synthesis completely do not affect cellular RNA synthesis.
D000963:Antimetabolites / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D006367:HeLa Cells / Q000378:metabolism; D017955:Poliovirus / Q000187:drug effects / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D012367:RNA, Viral / Q000096:biosynthesis*; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D000963:Antimetabolites; D000998:Antiviral Agents; D012367:RNA, Viral; D014764:Viral Proteins; D014316:Tritium; D003609:Dactinomycin; D012313:RNA; D014529:Uridine