title: Mouse leukemia virus activation by chemical carcinogens.
abstract: The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D002273:Carcinogens; D003168:Complement Fixation Tests; D009052:Leukemia Virus, Murine / Q000276:immunology*; D008223:Lymphoma / Q000139:chemically induced / Q000276:immunology*; D008748:Methylcholanthrene; D051379:Mice; D009602:Nitrosamines; D014520:Urethane
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; D014520:Urethane; D008748:Methylcholanthrene