Bordetella pertussis-induced alteration of the normal hyperglycemic response of mice to 3',5'-adenosine phosphate.
Blockade of the adrenergic receptors or the injection of Bordetella pertussis vaccine prevented the normal hyperglycemic response of CFW mice to exogenous cyclic 3',5'-adenosine phosphate (3',5'-AMP). The cyclic nucleotide was also ineffective in offsetting the histamine hypersensitivity of the beta-adrenergically blocked and the pertussis-sensitized groups. These observations suggest that the autonomic malfunction occurs at a point(s) subsequent to release of 3',5'-AMP. Neither the hyperglycemic effect of epinephrine or 3',5'-AMP, or both, nor the histamine sensitivity of pertussis-pretreated animals was influenced by the subcutaneous administration of theophylline.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001886:Bordetella pertussis; D000242:Cyclic AMP / Q000494:pharmacology; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000633:toxicity; D006943:Hyperglycemia / Q000503:physiopathology; D006969:Hypersensitivity, Immediate / Q000503:physiopathology; D051379:Mice; D010567:Pertussis Vaccine; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D000227:Adenine Nucleotides; D001786:Blood Glucose; D010567:Pertussis Vaccine; D003983:Dibenzylchlorethamine; D006632:Histamine; D011433:Propranolol; D013806:Theophylline; D000242:Cyclic AMP; D004837:Epinephrine; D010646:Phentolamine