Virus-induced murine leukemia: its inhibition and suppression by serum containing erythropoietin.
Mice infected at 2 days of age with a virus that induces reticulum cell sarcoma and myeloerythroleukemia were treated with erythropoietin-containing serum obtained from rabbits that had been treated with acetylphenylhydrazine. A marked inhibition of tumor induction occurred, particularly in females, when treatment was begun early. Delayed treatment resulted in instances of regression of overt neoplasia.
D000818:Animals; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D007116:Immunization, Passive; D066298:In Vitro Techniques; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000517:prevention & control*; D008297:Male; D051379:Mice; D011817:Rabbits; D012723:Sex; D013154:Spleen / Q000473:pathology
D004921:Erythropoietin