Pineal gland: dibutyryl cyclic adenosine monophosphate stimulation of labeled melatonin production.
In organ cultures of intact rat pineal glands, N(6)O(2')-dibutyryl adenosine 3', 5'-monophosphate stimulates the conversion of tritiated trytophan to tritiated melatonin, as does L-norepinephrine. Potential sites of stimulation of melatonin production by dibutyryl cyclic adenosine monophosphate are discussed, based on observations that the dibutyryl analog also stimulates the conversion of serotonin labeled with carbon-14 to carbon-14-labeled melatonin without altering hydroxyin-dole-O-methyl transferase activity or intracellular accumulation of serotonin labeled with carbon-14.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002247:Carbon Isotopes; D000242:Cyclic AMP / Q000494:pharmacology; D066298:In Vitro Techniques; D008550:Melatonin / Q000096:biosynthesis*; D009638:Norepinephrine / Q000494:pharmacology; D010870:Pineal Gland / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013268:Stimulation, Chemical; D014166:Transferases / Q000378:metabolism; D014316:Tritium; D014364:Tryptophan / Q000378:metabolism
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D014316:Tritium; D012701:Serotonin; D014364:Tryptophan; D000242:Cyclic AMP; D014166:Transferases; D008550:Melatonin; D009638:Norepinephrine