Microsomal ring-fission of cis- and trans-acenaphthene-1,2-diol.
1. The ring-fission of cis- and trans-acenaphthene-1,2-diol by rat liver microsomes was studied. 2. 1,8-Naphthalic acid was detected and isolated after microsomal incubations of the diols. 3. The accompanying reduction of NAD(+) was followed spectrophotometrically. 4. The optimum pH for the microsomal reaction was 9.4 for the oxidation of the cis-diol and 9.8 for that of the trans-diol. 5. p-Chloromercuribenzoate and 2,4-dichlorophenol inhibited the reaction. 6. Possible mechanisms for the microsomal ring-fission, involving 1,8-naphthalic aldehyde, are discussed.
D000438:Alcohols; D000818:Animals; D001386:Azides / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D002498:Centrifugation; D002729:Chloromercuribenzoates / Q000494:pharmacology; D003864:Depression, Chemical; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009281:Naphthalenes / Q000378:metabolism*; D010084:Oxidation-Reduction; D010636:Phenols / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013053:Spectrophotometry; D013237:Stereoisomerism
D000438:Alcohols; D001386:Azides; D002729:Chloromercuribenzoates; D009281:Naphthalenes; D010636:Phenols; D009243:NAD; D011335:Proadifen