Comparison of the adrenocorticotrophic activities of two synthetic polypeptides: synacthen and DW 75.
The adrenocorticotrophic activities of two synthetic polypeptides, Synacthen (Ciba) and DW 75 (Sandoz), were compared in two groups of patients having a variety of arthritic disorders. Compared with Synacthen, injected either intramuscularly or intravenously, intravenous DW 75 was found to have a longer duration of adrenocorticotrophic activity (measured by plasma 11-hydroxycorticosteroid levels) in both groups of patients, while intramuscularly administered DW 75 did not appear to be absorbed well.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D005938:Glucocorticoids / Q000097:blood; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D010455:Peptides / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D010455:Peptides; D000324:Adrenocorticotropic Hormone