title: Antibody to human follicle-stimulating hormone: cross-reactivity with three other hormones.
abstract: Antibodies directed against human follicle-stimulating hormone (FSH) were demonstrated in rabbit serum by neutralization of biological activity. Antibodies that bound FSH-(131)I were produced in rabbits and guinea pigs by repeated injections of FSH. By (131)I immunochemical methods, we found that at least 90% of the FSH-(131)I-binding antibody failed to distinguish the four human glycoprotein hormones: FSH, luteinizing hormone, chorionic gonadotropin, and thyrotropin, purified as well as endogenous hormone in plasma. Neither growth hormone, adrenocorticotropin, nor a variety of glycoproteins or animal plasmas were able to react with these antibodies.
mesh_terms: D000324:Adrenocorticotropic Hormone; D000818:Animals; D000937:Antigen-Antibody Reactions; D006063:Chorionic Gonadotropin / Q000097:blood*; D004700:Endocrine System Diseases / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D013006:Growth Hormone; D006168:Guinea Pigs; D006801:Humans; D007118:Immunoassay; D007456:Iodine Isotopes; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011817:Rabbits; D013972:Thyrotropin / Q000097:blood*
chemical_list: D006063:Chorionic Gonadotropin; D007456:Iodine Isotopes; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone