title: Urea and thermal mutants of poliovirus.
abstract: Hallum, J. V. (University of Pittsburgh, Pittsburgh, Pa.), and J. S. Youngner. Urea and thermal mutants of poliovirus. J. Bacteriol. 91:2305-2308. 1966.-Thermally selected mutants of poliovirus which differed in sensitivity to heating at 50 C were inactivated with urea. With 3 m urea, urea resistance paralleled thermal resistance. In contrast, when urea-resistant mutants were selected from thermosensitive, urea-sensitive, wild-type poliovirus, the 50 C sensitivity of the selected mutants did not change. These findings indicate a lack of covariance of the urea and the 50 C-inactivation markers of poliovirus.
mesh_terms: D003553:Cystine / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006321:Heart; D066298:In Vitro Techniques; D009154:Mutation; D017955:Poliovirus / Q000187:drug effects / Q000254:growth & development*; D014508:Urea / Q000494:pharmacology*
chemical_list: D003553:Cystine; D014508:Urea