Brain alcohol dehydrogenase.
Significant alcohol dehydrogenase activity has been demonstrated in the soluble fraction of rat brain and is very similar to the liver enzyme in kinetic properties and responses to inhibitors. A cerebral mechanism that oxidizes ethanol may play a significant role in local adjustments during exposure to ethanol and in the pathogenesis of the neural disorders associated with chronic alcohol ingestion or withdrawal.
D000079:Acetaldehyde / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000447:Aldehydes / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000378:metabolism; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D000431:Ethanol / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D009422:Nervous System Diseases / Q000209:etiology; D011409:Propylene Glycols / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D013440:Sulfides / Q000494:pharmacology
D000447:Aldehydes; D002247:Carbon Isotopes; D011409:Propylene Glycols; D011720:Pyrazoles; D013440:Sulfides; D009243:NAD; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D000079:Acetaldehyde