Streptolydigin, an inhibitor of oxidative phosphorylation in rat liver mitochondria.
Streptolydigin interferes with oxidative phosphorylation in rat liver mitochondria. The agent acts primarily as an uncoupler of respiration-associated phosphorylation but also impairs respiration to various degrees depending on the substrate. Streptolydigin partially inhibits electron flow at a point past the cytochrome b and prior to the cytochrome c reduction site. Streptolydigin also inhibits the function of the enzyme ribonucleic acid polymerase in whole bacterial cells and cell-free systems. The streptolydigin concentrations that cause effective inhibition of ribonucleic acid polymerase in cell-free systems are approximately 10 times less than those required to inhibit oxidative phosphorylation in mitochondria.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000968:Antimycin A / Q000494:pharmacology; D002951:Citrates / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism; D006885:Hydroxybutyrates / Q000378:metabolism; D008293:Malates / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D012316:RNA Nucleotidyltransferases / Q000037:antagonists & inhibitors; D013386:Succinates / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002951:Citrates; D005971:Glutamates; D006885:Hydroxybutyrates; D008293:Malates; D013386:Succinates; D009243:NAD; D000968:Antimycin A; D010088:Oxidoreductases; D012316:RNA Nucleotidyltransferases