title: Regulation of the adrenal cortex secretory pattern by adrenocorticotropin.
abstract: Adrenal gland homogenates from rabbits stimulated for 28 days with adrenocorticotropin have been shown to synthesize cortisol. The total amount of cortisol formed was the same whether progesterone-4-(14)C or Delta(5)-pregnenolone-4-(14)C was used as exogenous substrate. However, when Delta(5)-pregnenolone substrate was used the specific activity of the isolated cortisol was four times as great as when progesterone was used.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D003345:Corticosterone / Q000096:biosynthesis* / Q000302:isolation & purification; D003900:Desoxycorticosterone / Q000096:biosynthesis* / Q000302:isolation & purification; D006854:Hydrocortisone / Q000096:biosynthesis* / Q000302:isolation & purification; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010913:Pituitary-Adrenal System; D011284:Pregnenolone / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism*; D011817:Rabbits; D013268:Stimulation, Chemical
chemical_list: D002247:Carbon Isotopes; D003900:Desoxycorticosterone; D011374:Progesterone; D011284:Pregnenolone; D000324:Adrenocorticotropic Hormone; D006899:Mixed Function Oxygenases; D003345:Corticosterone; D006854:Hydrocortisone