Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia.
Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 mug/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary. The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital; D000308:Adrenocortical Hyperfunction / Q000097:blood*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000328:Adult; D002648:Child; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D002940:Circadian Rhythm; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005474:Fluoxymesterone / Q000494:pharmacology; D006801:Humans; D006908:Hydroxyprogesterones / Q000096:biosynthesis / Q000097:blood*; D006965:Hyperplasia / Q000097:blood / Q000151:congenital; D007985:Leydig Cells / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008598:Menstruation; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011374:Progesterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D006908:Hydroxyprogesterones; D011374:Progesterone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005474:Fluoxymesterone