title: Statolon-induced resistance of mice to mengovirus.
abstract: Mice receiving statolon intraperitoneally were 1,000 times more resistant to intraperitoneal challenge with mengovirus than were untreated controls. Protection was afforded when statolon was administered 1 day before or 1 day after intraperitoneal inoculation with the virus. No therapeutic effect was observed when treatment with statolon was delayed for 2 days or more after virus infection. Exposure of mice to a simulated space cabin environment did not increase their susceptibility to the lethal effects of mengovirus infection or eliminate the protective effect of statolon.
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004686:Encephalomyocarditis virus; D007372:Interferons; D008297:Male; D051379:Mice; D013026:Space Flight
chemical_list: D000998:Antiviral Agents; D007372:Interferons