Mast cells and necrosis.
Subcutaneous injections of normally well tolerated amounts of hypertonic NaCl or urea solutions produce extensive topical necroses in rats systemically treated with various mast-cell dischargers and mast-cell products. This response is considered to be closely related to mitast-cell function, for it cannot be duplicated by systemic treatment with a variety of other agents.
D000818:Animals; D003911:Dextrans / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D006982:Hypertonic Solutions / Q000494:pharmacology*; D008407:Mast Cells / Q000502:physiology*; D009336:Necrosis / Q000209:etiology*; D009638:Norepinephrine / Q000494:pharmacology; D011113:Polymyxins / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology*; D013312:Stress, Physiological; D014508:Urea / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003911:Dextrans; D006982:Hypertonic Solutions; D011113:Polymyxins; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D012965:Sodium Chloride; D006632:Histamine; D014508:Urea; D006493:Heparin; D009638:Norepinephrine; D004837:Epinephrine