Glucagon-sensitive adenyl cylase in plasma membrane of hepatic parenchymal cells.
The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon. Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho-diesterase activity is present in the membrane. These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.
D000227:Adenine Nucleotides; D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D005934:Glucagon / Q000494:pharmacology* / Q000502:physiology; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D010759:Phosphorus Isotopes; D051381:Rats; D013268:Stimulation, Chemical
D000227:Adenine Nucleotides; D004798:Enzymes; D010759:Phosphorus Isotopes; D000255:Adenosine Triphosphate; D005934:Glucagon; D000242:Cyclic AMP; D000262:Adenylyl Cyclases