Human granulocyte collagenase.
A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.
D000180:Acrylic Resins; D001183:Arthus Reaction; D002247:Carbon Isotopes; D003094:Collagen / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000201:enzymology*; D004586:Electrophoresis; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D007962:Leukocytes / Q000166:cytology / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology; D003012:Microbial Collagenase / Q000097:blood*; D009504:Neutrophils / Q000201:enzymology; D014783:Viscosity
D000180:Acrylic Resins; D002247:Carbon Isotopes; D005782:Gels; D003094:Collagen; D003012:Microbial Collagenase