Potassium, corticosterone, and adrenocorticotropic hormone release in vitro.
Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release. This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000502:physiology*; D005246:Feedback; D006982:Hypertonic Solutions; D066298:In Vitro Techniques; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010913:Pituitary-Adrenal System; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D006982:Hypertonic Solutions; D000324:Adrenocorticotropic Hormone; D011188:Potassium; D003345:Corticosterone