Pituitary tumors in mice after prolonged feeding of synthetic progestins.
An enhanced development of pituitary tumors was observed in virgin female mice of the C57 Leaden strain following repeated oral administration of synthetic progestins. This finding appears to parallel the co-carcinogenic enhancement of mammary tumor development elicited in C3H mice treated repeatedly with progesterone.
D000818:Animals; D001681:Biological Assay; D006528:Carcinoma, Hepatocellular; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D008113:Liver Neoplasms; D051379:Mice; D009640:Norethindrone / Q000494:pharmacology*; D009641:Norethynodrel / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000209:etiology*
D004997:Ethinyl Estradiol; D009641:Norethynodrel; D009640:Norethindrone