Polyol pathway in aorta: regulation by hormones.
Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011817:Rabbits; D013012:Sorbitol / Q000378:metabolism*
D000804:Angiotensin II; D013012:Sorbitol; D010042:Ouabain; D000242:Cyclic AMP; D000429:Alcohol Oxidoreductases; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine