Cyclic adenosine monophosphate: stimulation of melatonin and serotonin synthesis in cultured rat pineals.
Dibutyryl cyclic adenosine monophosphate, like norepinephrine, stimulates the synthesis of labeled melatonin and serotonin from tryptophan labeled with carbon-14 by rat pineals in organ culture. Unlike norepinephrine, dibutyryl cyclic adenosine monophosphate does not enhance the accumulation of labeled tryptophan or protein within the pineal. These findings are compatible with the hypothesis that cyclic adenosine monophosphate mediates some, but not all, of the effects of norepinephrine.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002247:Carbon Isotopes; D046508:Culture Techniques; D000242:Cyclic AMP / Q000494:pharmacology; D005260:Female; D008550:Melatonin / Q000096:biosynthesis*; D009638:Norepinephrine / Q000494:pharmacology; D010870:Pineal Gland / Q000187:drug effects*; D051381:Rats; D012701:Serotonin / Q000096:biosynthesis*; D014364:Tryptophan / Q000378:metabolism
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D012701:Serotonin; D014364:Tryptophan; D000242:Cyclic AMP; D008550:Melatonin; D009638:Norepinephrine