title: Hybrid of monkey and human adenoviruses.
abstract: Following joint replication of monkey SA7 adenovirus (C8 strain) and human adenovirus type 2 in green monkey kidney tissue culture, a virus possessing the properties of a hybrid was obtained. It was designated Ad2C8. Ad2C8 preparations contained two types of viral particles: human adenovirus type 2, and hybrid particles. The hybrid virions multiplied in green monkey kidney cells in the presence of human adenovirus types 1, 2, and 3, but not 3 and 7, and acquired the capsid of the helper adenovirus. The hybrid can serve as a helper for human adenoviruses. It can apparently induce T antigen of the C8 virus but, in contrast to the latter, does not induce tumors in hamsters.
mesh_terms: D000256:Adenoviridae / Q000276:immunology / Q000472:pathogenicity; D000257:Adenoviridae Infections; D000818:Animals; D000941:Antigens / Q000032:analysis; D006224:Cricetinae; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D006378:Helper Viruses; D006801:Humans; D006824:Hybridization, Genetic; D007668:Kidney; D008992:Monkey Diseases; D009374:Neoplasms, Experimental / Q000209:etiology; D009500:Neutralization Tests; D014779:Virus Replication
chemical_list: D000941:Antigens