title: Possible mechanism for increased purine biosynthesis de novo in Lesch-Nyhan syndrome.
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D001377:Azaserine; D046508:Culture Techniques; D011756:Diphosphates / Q000378:metabolism; D005246:Feedback; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008025:Ligases / Q000037:antagonists & inhibitors; D008967:Molecular Biology; D009154:Mutation; D011686:Purine-Pyrimidine Metabolism, Inborn Errors / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis*; D012867:Skin / Q000166:cytology
chemical_list: D000227:Adenine Nucleotides; D011756:Diphosphates; D011687:Purines; D001377:Azaserine; D008025:Ligases