A difference in the architecture of the surface membrane of normal and virally transformed cells.
Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same agglutinin receptor sites in a fashion indistinguishable from the transformed cells, it is proposed that both viral and chemical transformation produce changes in the architecture of the membrane, identical to those of the proteases.
D000818:Animals; D000906:Antibodies; D001665:Binding Sites; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002642:Chick Embryo; D006224:Cricetinae; D046508:Culture Techniques; D004589:Electrophoresis, Disc; D005347:Fibroblasts; D007668:Kidney; D037102:Lectins / Q000302:isolation & purification; D008099:Liver; D008566:Membranes; D008722:Methods; D009374:Neoplasms, Experimental; D009858:Oncogenic Viruses; D010447:Peptide Hydrolases; D051381:Rats; D013539:Simian virus 40
D000906:Antibodies; D037102:Lectins; D010447:Peptide Hydrolases