Induction of liver acetaldehyde dehydrogenase: possible role in ethanol tolerance after exposure tobarbiturates.
Mice were injected twice a day for 4 days with saline or phenobarbital or ethanol. Treatment with phenobarbital, but not ethanol, increased the amount of liver acetaldehyde dehydrogenase activity. More rapid removal of acetaldehyde, which is a toxic metabolic intermediate of ethanol, may contribute to the alcohol tolerance exhibited by persons who use barbiturates regularly.
D000079:Acetaldehyde / Q000378:metabolism; D000818:Animals; D004361:Drug Tolerance; D004790:Enzyme Induction; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009243:NAD / Q000032:analysis; D010088:Oxidoreductases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology*; D013053:Spectrophotometry
D009243:NAD; D000431:Ethanol; D010088:Oxidoreductases; D000079:Acetaldehyde; D010634:Phenobarbital