5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats.
A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25-hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002762:Cholecalciferol / Q000494:pharmacology*; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D013268:Stimulation, Chemical
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol; D002118:Calcium