title: Properties of a R factor which originated in Pseudomonas aeruginosa 1822.
abstract: RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aeruginosa, Escherichia coli, and Proteus mirabilis. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm(3) (60% guanine plus cytosine).
mesh_terms: D001965:Bromides; D002228:Carbenicillin / Q000494:pharmacology; D002499:Centrifugation, Density Gradient; D002586:Cesium; D002712:Chlorides; D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000032:analysis / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects; D004996:Ethidium; D005815:Genetic Code; D005827:Genetics, Microbial; D002479:Inclusion Bodies; D007612:Kanamycin / Q000494:pharmacology; D008970:Molecular Weight; D009355:Neomycin / Q000494:pharmacology; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D010759:Phosphorus Isotopes; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology; D013395:Sucrose; D013752:Tetracycline / Q000494:pharmacology; D014316:Tritium
chemical_list: D001965:Bromides; D002712:Chlorides; D004269:DNA, Bacterial; D010759:Phosphorus Isotopes; D014316:Tritium; D002586:Cesium; D013395:Sucrose; D007612:Kanamycin; D010405:Penicillinase; D004996:Ethidium; D013752:Tetracycline; D002228:Carbenicillin; D009355:Neomycin