title: Studies on the structure and metabolism of glycogen in some abnormal human infants.
abstract: 1. The liver and muscle tissues of 14 human anencephalic babies were examined for glycogen content and structure, and for the activities of several glycogen-metabolizing enzymes. 2. In both tissues glycogen content increased with gestation age; the muscle glycogens had a slightly but significantly lower degree of branching than the corresponding liver glycogens. 3. All the expected glycogen-metabolizing enzymes were present; acid maltase activities were higher and phosphoglucomutase activities were lower than the results reported for human adult tissues. Glucose 6-phosphatase activity increased significantly with gestation age.
mesh_terms: D000757:Anencephaly / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005959:Glucosidases / Q000378:metabolism; D005964:Glucosyltransferases / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000201:enzymology; D008112:Liver Glycogen / Q000378:metabolism; D009132:Muscles / Q000201:enzymology / Q000378:metabolism; D010733:Phosphoglucomutase / Q000378:metabolism
chemical_list: D008112:Liver Glycogen; D006003:Glycogen; D005964:Glucosyltransferases; D005952:Glucose-6-Phosphatase; D005959:Glucosidases; D006026:Glycoside Hydrolases; D010733:Phosphoglucomutase