Growth inhibition of sympathetic cells by some adrenergic blocking agents (6-hydroxydopamine-mice and rats-immunosympathectomy-chemical sympathectomy-superior cervical ganglion).
Treatment of newborn mice and rats with the adrenergic blocking agents, guanethidine and bretylium tosylate, results in massive destruction of immature sympathetic nerve cells. A growth inhibition of the same cells is caused by reserpine. Similarities and differences between the effects elicited by these three ganglion blocking agents and a dopamine analog, 6-hydroxydopamine, are discussed.
D000313:Adrenal Medulla / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects; D001949:Bretylium Compounds / Q000494:pharmacology*; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology*; D004721:Endoplasmic Reticulum / Q000187:drug effects; D005725:Ganglia, Autonomic / Q000166:cytology / Q000187:drug effects; D006056:Golgi Apparatus / Q000187:drug effects; D006145:Guanethidine / Q000494:pharmacology*; D051379:Mice; D008854:Microscopy, Electron; D008933:Mitochondrial Swelling / Q000187:drug effects; D009433:Neural Inhibition; D009474:Neurons / Q000187:drug effects; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000166:cytology / Q000187:drug effects*; D013565:Sympatholytics / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D014105:Tosyl Compounds / Q000494:pharmacology
D001949:Bretylium Compounds; D013565:Sympatholytics; D014105:Tosyl Compounds; D004298:Dopamine; D006145:Guanethidine