Contraction of granulation tissue in vitro: similarity to smooth muscle.
Strips of granulation tissue from three different experimental models contract in vitro when treated with substances that induce contraction of smooth muscle. Because the fibroblasts in such tissues have some ultrastructural features typical of smooth muscle, our findings indicate that fibroblasts are able to modulate toward a cell type that is morphologically and functionally close to smooth muscle.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D006097:Granulation Tissue / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology; D014945:Wound Healing
D014667:Vasopressins; D000804:Angiotensin II; D012701:Serotonin; D006632:Histamine; D010208:Papaverine; D001920:Bradykinin; D004837:Epinephrine