Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera.
Inhibition of the ribonucleic acid (RNA)- and deoxyribonucleic acid (DNA)-dependent DNA polymerase activities of mammalian C-type viruses was obtained with sera from rats bearing murine leukemia virus-induced transplant tumors. Polymerase activities of nonmammalian (viper) C-type virus and murine mammary tumor virus were not inhibited by such sera nor by serum from a rat immunized with the DNA polymerase of feline leukemia virus purified by isoelectric focusing. The latter serum appeared to inhibit preferentially the DNA-dependent DNA polymerase activity of mammalian C-type viruses showing no inhibition of RNA-dependent DNA synthesis.
D000818:Animals; D000956:Antigens, Viral; D002415:Cats; D006224:Cricetinae; D004254:DNA Nucleotidyltransferases / Q000302:isolation & purification; D007106:Immune Sera; D007525:Isoelectric Focusing; D007942:Leukemia, Experimental / Q000097:blood; D008324:Mammary Tumor Virus, Mouse / Q000201:enzymology / Q000276:immunology; D051379:Mice; D009858:Oncogenic Viruses / Q000201:enzymology* / Q000276:immunology; D051381:Rats; D012190:Retroviridae / Q000201:enzymology / Q000276:immunology; D012911:Snakes
D000956:Antigens, Viral; D007106:Immune Sera; D004254:DNA Nucleotidyltransferases