title: Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro.
mesh_terms: D000818:Animals; D001673:Biodegradation, Environmental; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D002460:Cell Line; D002478:Cells, Cultured; D002850:Chromatography, Gel; D003513:Cycloheximide / Q000494:pharmacology; D004355:Drug Stability; D004586:Electrophoresis; D004789:Enzyme Activation / Q000187:drug effects; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D002955:Leucovorin / Q000494:pharmacology; D007939:Leukemia L1210 / Q000201:enzymology; D008113:Liver Neoplasms; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D051381:Rats; D013762:Tetrahydrofolate Dehydrogenase / Q000097:blood / Q000302:isolation & purification / Q000378:metabolism*; D014223:Triamterene / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D005493:Folic Acid Antagonists; D003513:Cycloheximide; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D002955:Leucovorin; D014223:Triamterene; D008727:Methotrexate