title: Heterogeneity of murine leukemia virus in vitro DNA; detection of viral DNA in mammalian cells.
abstract: Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of double-stranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells and cells containing RNA tumor virus.
mesh_terms: D000818:Animals; D002460:Cell Line / Q000382:microbiology; D002471:Cell Transformation, Neoplastic; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004279:DNA, Viral / Q000032:analysis*; D005827:Genetics, Microbial; D007668:Kidney; D007700:Kinetics; D009052:Leukemia Virus, Murine / Q000378:metabolism*; D051379:Mice; D051381:Rats; D011925:Rauscher Virus / Q000378:metabolism*; D014316:Tritium; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D014316:Tritium; D004254:DNA Nucleotidyltransferases