Chronic fenfluramine administration: some cerebral effects.
Human cerebral function was monitored electrophysiologically during sleep over a period of months before, during, and after the intake of fenfluramine, 40-120 mg/day. Effects included dose-related reduction of paradoxical sleep, increase of intra-sleep restlessness, and changes in E.E.G. slow-wave sleep. It is hypothesized that weight loss may be associated with increase of the last. Grinding of teeth (bruxism) also was noted.Long-term studies make it possible to demonstrate changing central effects with time, including tolerance phenomena. Withdrawal abnormalities are related to the time taken for the drug to be eliminated-in the present case reaching a maximum four days after withdrawal.
D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D002012:Bruxism / Q000139:chemically induced; D004361:Drug Tolerance; D004569:Electroencephalography; D005277:Fenfluramine / Q000009:adverse effects; D005461:Fluorine / Q000009:adverse effects; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000009:adverse effects*; D010919:Placebos; D012893:Sleep Wake Disorders / Q000139:chemically induced; D012895:Sleep, REM / Q000187:drug effects; D013375:Substance Withdrawal Syndrome; D013997:Time Factors
D001067:Appetite Depressants; D010627:Phenethylamines; D010919:Placebos; D005461:Fluorine; D005277:Fenfluramine