Interferon production in mice by cell wall mutants of Salmonella typhimurium.
The interferon response elicited by Salmonella typhimurium mutants in mice is not dependent on the presence of a complete cell wall lipopolysaccharide. In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indistinguishable in its interferon-stimulating ability from the wild type which possesses a complete O antigen with polysaccharide side chains.
D000818:Animals; D000941:Antigens; D002473:Cell Wall / Q000378:metabolism; D003513:Cycloheximide; D004731:Endotoxins / Q000096:biosynthesis; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000096:biosynthesis; D051379:Mice; D009154:Mutation; D009163:Mycobacterium bovis / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000378:metabolism* / Q000472:pathogenicity; D014721:Vesicular stomatitis Indiana virus
D000941:Antigens; D004731:Endotoxins; D008070:Lipopolysaccharides; D007372:Interferons; D003513:Cycloheximide