title: Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity.
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000652:urine; D001580:Benzopyrenes / Q000378:metabolism; D003348:Cortisone / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003574:Cytochrome c Group; D003640:Dealkylation; D003975:Diazepam / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology; D006900:Hydroxylation; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D009020:Morphine / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010433:Pentylenetetrazole / Q000494:pharmacology; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012106:Research; D012890:Sleep / Q000187:drug effects; D013148:Spironolactone / Q000494:pharmacology
chemical_list: D001555:Benzene Derivatives; D001580:Benzopyrenes; D003574:Cytochrome c Group; D004364:Pharmaceutical Preparations; D013148:Spironolactone; D008748:Methylcholanthrene; D009020:Morphine; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D010088:Oxidoreductases; D003975:Diazepam; D003348:Cortisone; D010433:Pentylenetetrazole; D010634:Phenobarbital