Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord.
The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition.
D000200:Action Potentials; D000470:Alkaloids / Q000494:pharmacology*; D000613:Aminobutyrates / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001001:Anura; D004149:Dioxoles / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D004566:Electrodes; D005071:Evoked Potentials; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D009467:Neuromuscular Depolarizing Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009475:Neurons, Afferent / Q000187:drug effects; D011894:Rana pipiens; D012018:Reflex; D013116:Spinal Cord / Q000187:drug effects; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D000470:Alkaloids; D000613:Aminobutyrates; D004149:Dioxoles; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates; D007546:Isoquinolines; D009467:Neuromuscular Depolarizing Agents