Calcium as a mediator of adrenocorticotrophic hormone action on adrenal protein synthesis.
Calcium stimulates leucine incorporation into protein during incubations of sections and cell-free preparations of the rat adrenal. Like adrenocorticotrophic hormone (ACTH) action, calcium enhances the transfer of amino acid from transfer RNA to protein. Stimulation of leucine incorporation by ACTH and cyclic adenosine monophosphate is best observed when sections are incubated in limiting calcium concentrations.
D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002474:Cell-Free System; D000242:Cyclic AMP / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis; D012343:RNA, Transfer / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013997:Time Factors
D011506:Proteins; D000324:Adrenocorticotropic Hormone; D012343:RNA, Transfer; D000242:Cyclic AMP; D007930:Leucine; D002118:Calcium