Hyperoxaluria in L-glyceric aciduria: possible pathogenic mechanism.
The effect of hydroxypyruvate on synthesis of oxalate and glycolate from glyoxylate was studied in in vitro preparations from normal human erythrocytes and leukocytes, rat liver, and with purified lactate dehydrogenase from beef heart. In the presence of reduced nicotinamide adenine dinucleotide, hydroxypyruvate stimulated the oxidation of glyoxylate to oxalate and decreased the reduction of glyoxylate to glycolate. These findings may explain the hyperoxaluria seen in L-glyceric aciduria (type II primary hyperoxaluria).
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000592:Amino Acid Metabolism, Inborn Errors / Q000209:etiology*; D000818:Animals; D002247:Carbon Isotopes; D002417:Cattle; D002852:Chromatography, Ion Exchange; D004912:Erythrocytes / Q000378:metabolism; D005988:Glyceric Acids / Q000652:urine*; D006016:Glycolates / Q000096:biosynthesis*; D006038:Glyoxylates / Q000378:metabolism*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D010070:Oxalates / Q000096:biosynthesis* / Q000652:urine*; D011773:Pyruvates / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D002247:Carbon Isotopes; D005988:Glyceric Acids; D006016:Glycolates; D006038:Glyoxylates; D010070:Oxalates; D011773:Pyruvates; D009243:NAD; D000429:Alcohol Oxidoreductases; D007770:L-Lactate Dehydrogenase