Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells.
Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions.
D000818:Animals; D002633:Chemotaxis; D003165:Complement System Proteins; D003470:Culture Media; D046508:Culture Techniques; D006168:Guinea Pigs; D007249:Inflammation; D007962:Leukocytes; D011817:Rabbits; D018139:Simplexvirus; D014776:Virus Cultivation
D003470:Culture Media; D003165:Complement System Proteins