Prostaglandins and their effects on human placental adenyl cyclase.
Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F(1alpha) < A(2), F(2alpha), B(2) < A(1) < E(2) < E(1). Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D046508:Culture Techniques; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D006801:Humans; D010920:Placenta / Q000187:drug effects / Q000201:enzymology*; D011247:Pregnancy; D011453:Prostaglandins / Q000494:pharmacology*; D013268:Stimulation, Chemical
D011453:Prostaglandins; D000242:Cyclic AMP; D000262:Adenylyl Cyclases