Inhibition of angiotensin I converting enzyme by venom peptides.
The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition.
D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D004357:Drug Synergism; D004791:Enzyme Inhibitors; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000201:enzymology; D009119:Muscle Contraction / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology; D010477:Perfusion; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D014688:Venoms / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D010455:Peptides; D014688:Venoms; D000804:Angiotensin II