title: Homologies in amino acid composition and structure of histone F2al isolated from human leukaemic cells.
abstract: Histones F2al extracted from normal and neoplastic cells possess similar amino acid compositions. Tryptic and chymotryptic peptides of the F2al histones have identical chromato-electrophoretic R(F) values. It is concluded that histones F2al from various sources have similar overall structures. The observed differences in the ratios of in-N-monomethyl- and di-in-N-methyl-lysine in the histones from normal and neoplastic cells may be of significance with respect to gene regulation.
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002417:Cattle; D002460:Cell Line; D002845:Chromatography; D002850:Chromatography, Gel; D002918:Chymotrypsin; D003486:Cyanides; D004589:Electrophoresis, Disc; D006657:Histones / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008113:Liver Neoplasms; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D013950:Thymus Gland / Q000032:analysis; D014357:Trypsin
chemical_list: D000596:Amino Acids; D003486:Cyanides; D006657:Histones; D002918:Chymotrypsin; D014357:Trypsin