Microbial transformation of 19-hydroxypregnanes.
Nocardia species aromatized 19-hydroxyprogesterone, 3beta, 19-dihydroxy-pregn-5-en-20-one 3-acetate and pregn-5-ene-3beta, 19, 20beta-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19-hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20-dione as substrate, the transformation was more complex and many products were formed.
D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D004970:Estrone / Q000096:biosynthesis; D005658:Fungi / Q000378:metabolism*; D005782:Gels; D006908:Hydroxyprogesterones / Q000378:metabolism*; D009615:Nocardia / Q000378:metabolism*; D011278:Pregnanes / Q000378:metabolism*; D012822:Silicon Dioxide
D005782:Gels; D006908:Hydroxyprogesterones; D011278:Pregnanes; D004970:Estrone; D012822:Silicon Dioxide