Antiviral activity of polyribocytidylic acid in cells primed with polyriboinosinic acid.
Separate administration of polyribocytidylic acid [poly(rC)] and polyriboinosinic acid [poly(rI)] to cell cultures in vitro resulted in an antiviral activity identical to or greater than that resulting from addition of the poly(rI) * poly(rC) complex. Priming of cells with poly(rI), followed by treatment with poly(rC), gave a consistently greater antiviral activity than poly(rI) * poly(rC) itself. This priming effect was obtained in several cell cultures challenged with different viruses. In vivo, the antiviral activity of poly(rI) * poly(rC) was only partially restored if poly(rI) and poly(rC) were injected separately; prior injection of poly(rI) proved superior in restoring this antiviral activity as compared to prior injection of poly(rC).
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003597:Cytosine Nucleotides / Q000008:administration & dosage; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology; D011108:Polymers; D011119:Polynucleotides / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014616:Vaccinia virus / Q000187:drug effects*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*; D014776:Virus Cultivation
D000998:Antiviral Agents; D003597:Cytosine Nucleotides; D011108:Polymers; D011119:Polynucleotides; D007372:Interferons; D011070:Poly I-C