Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin.
A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat-labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin.
D000818:Animals; D002771:Cholera / Q000378:metabolism*; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D004285:Dogs; D004768:Enterotoxins / Q000494:pharmacology*; D005615:Freezing; D007413:Intestinal Mucosa / Q000032:analysis / Q000378:metabolism*; D014733:Vibrio / Q000378:metabolism
D004768:Enterotoxins; D000242:Cyclic AMP