Comparison of murine sarcoma viruses in nonproducer and S + L - -transformed cells.
The biologic properties of murine sarcoma viruses in nonproducer and S(+)L(-) cells were compared. Each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. There was no evidence for production of a defective murine leukemia virus by S(+)L(-) cells. The results are most consistent with the hypothesis that the sarcoma genome in S(+)L(-) cells contains information for replication functions which the virus in nonproducer cells either lacks or does not express.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D003168:Complement Fixation Tests; D017988:Gammaretrovirus / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D005827:Genetics, Microbial; D006378:Helper Viruses / Q000254:growth & development / Q000276:immunology; D009052:Leukemia Virus, Murine / Q000254:growth & development*; D051379:Mice; D008979:Moloney murine leukemia virus; D051381:Rats; D014316:Tritium; D014529:Uridine; D014779:Virus Replication
D000956:Antigens, Viral; D014316:Tritium; D014529:Uridine