Antiviral resistance by the polyinosinic acid-poly (1-vinylcytosine) complex.
The antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(I).poly(C)], which is a potent interferon inducer, have been studied. Structural changes that modify the polymer backbone substantially, such as loops or 2' --> 5' phosphodiester bonds, lead to decreased antiviral activity. Unexpectedly, however, the complex of polyinosinic acid and poly(1-vinylcytosine), which is only a much more distantly related analog of poly(I) . poly(C), shows high activity. It is postulated that the high activity is related to the reduction of the charge/mass ratio and to the existence of this complex in an aggregated state; these are two factors that generally enhance the uptake of compo unds by cells.
D000998:Antiviral Agents / Q000494:pharmacology*; D046508:Culture Techniques; D005347:Fibroblasts; D007372:Interferons / Q000096:biosynthesis; D011070:Poly I-C / Q000494:pharmacology; D011119:Polynucleotides / Q000138:chemical synthesis / Q000494:pharmacology*; D011145:Polyvinyls / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects*; D014776:Virus Cultivation
D000998:Antiviral Agents; D011119:Polynucleotides; D011145:Polyvinyls; D007372:Interferons; D011070:Poly I-C