title: Multiple forms of uridine kinase in normal and neoplastic rat liver.
abstract: Two species of uridine kinase with molecular weights of approximately 120000 (I) and 30000 (II) have been identified in the rat liver system. Species I predominates in the 7-day postnatal and adult rat liver and increases in the regenerating remnant of the latter after partial hepatectomy; the concentration of species II is low in these tissues. Species I also predominates in the slow-growing hepatomas 5123D and 7800. In contrast, II is the predominant form in the foetal rat liver and accounts for 40% of the total activity in the rapidly growing Novikoff ascites hepatoma. In contrast to species II, which was stable, species I was inactivated by preincubation for 30min at 37 degrees C, before assay at 23 degrees C.
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D002845:Chromatography; D003593:Cytoplasm / Q000201:enzymology; D005333:Fetus; D006498:Hepatectomy; D006358:Hot Temperature; D007527:Isoenzymes / Q000032:analysis*; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology*; D008115:Liver Regeneration; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000201:enzymology; D010770:Phosphotransferases / Q000032:analysis*; D051381:Rats; D014529:Uridine
chemical_list: D007527:Isoenzymes; D010770:Phosphotransferases; D014529:Uridine