title: Klebsiella aerogenes strain carrying drug-resistance determinants and a lac plasmid.
abstract: In addition to carrying determinants conferring resistance to at least two antibiotics, chloramphenicol and streptomycin, a Klebsiella aerogenes strain contains a plasmid responsible for increased beta-galactosidase activity. The plasmid can be transferred to Escherichia coli and Salmonella typhimurium strains. K. aerogenes segregants without the plasmid grow on lactose one-half as fast as the parent strain and contain only one-tenth to one-fifth as much beta-galactosidase.
mesh_terms: D000166:Acridines / Q000494:pharmacology; D000225:Adenine / Q000378:metabolism; D002701:Chloramphenicol / Q000494:pharmacology; D003227:Conjugation, Genetic; D000242:Cyclic AMP / Q000494:pharmacology; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology; D005111:Extrachromosomal Inheritance; D005690:Galactose / Q000378:metabolism; D005696:Galactosidases / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D007709:Klebsiella / Q000187:drug effects / Q000201:enzymology; D007785:Lactose / Q000378:metabolism; D009154:Mutation; D012486:Salmonella typhimurium / Q000201:enzymology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D013307:Streptomycin / Q000494:pharmacology; D013778:Tetrazolium Salts / Q000378:metabolism; D014161:Transduction, Genetic; D014170:Transformation, Genetic
chemical_list: D000166:Acridines; D004269:DNA, Bacterial; D013778:Tetrazolium Salts; D012967:Sodium Dodecyl Sulfate; D002701:Chloramphenicol; D000242:Cyclic AMP; D005696:Galactosidases; D005947:Glucose; D007785:Lactose; D000225:Adenine; D005690:Galactose; D013307:Streptomycin