Epinephrine-induced vacuole formation in parotid gland cells and its independence of the secretory process.
Catecholamines cause rapid release of K(+) and formation of vacuoles in acinar gland cells. A high K(+) concentration in the medium bathing parotid gland slices prevents vacuole formation by epinephrine and facilitates the secretion of most of the exportable amylase. N(6)-monobutyryl 3':5'-cyclic AMP does not cause K(+) release and vacuole formation although it efficiently induces amylase secretion. It is suggested that the secretory process is independent of vacuole formation.
D000681:Amylases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology; D003593:Cytoplasm / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D010306:Parotid Gland / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical
D000242:Cyclic AMP; D000681:Amylases; D011188:Potassium; D004837:Epinephrine