Human sarcomas contain RNA related to the RNA of a mouse leukemia virus.
Labeled DNA complementary to the RNA of the Rauscher leukemia virus was hybridized with RNA from the polysome fraction of human sarcomas. Eighteen out of 25 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no normal adult or fetal tissues showed significant amounts of RNA specific to mouse leukemia virus. It appears that human sarcomas contain RNA sequences homologous to those found in an agent related to a virus known to cause sarcomas in mice.
D000818:Animals; D001345:Autoradiography; D001354:Avian Leukosis Virus / Q000032:analysis; D002499:Centrifugation, Density Gradient; D004279:DNA, Viral / Q000032:analysis; D005354:Fibrosarcoma / Q000378:metabolism; D006801:Humans; D007890:Leiomyosarcoma / Q000378:metabolism; D008080:Liposarcoma / Q000378:metabolism; D008324:Mammary Tumor Virus, Mouse / Q000032:analysis; D051379:Mice; D009455:Neurofibroma / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012516:Osteosarcoma / Q000378:metabolism; D012334:RNA, Neoplasm / Q000032:analysis*; D012335:RNA, Ribosomal / Q000032:analysis*; D012367:RNA, Viral / Q000032:analysis*; D011925:Rauscher Virus / Q000032:analysis*; D012208:Rhabdomyosarcoma / Q000378:metabolism; D012509:Sarcoma / Q000378:metabolism*; D014316:Tritium
D004279:DNA, Viral; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D012367:RNA, Viral; D014316:Tritium