Phosphodiesterase inhibition as a mechanism for the diuretic activity of 1 ((tert-butylimino)methyl)-2-(3-indolyl)indoline hydrochloride (MJ-8592-1).
D000818:Animals; D001921:Brain / Q000201:enzymology; D002740:Chlorothiazide / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007097:Imines / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D007668:Kidney / Q000032:analysis / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009928:Organ Specificity; D010208:Papaverine / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000494:pharmacology
D004232:Diuretics; D007097:Imines; D007211:Indoles; D010726:Phosphodiesterase Inhibitors; D002740:Chlorothiazide; D012964:Sodium; D013806:Theophylline; D010208:Papaverine; D000242:Cyclic AMP; C001961:MJ-8592-1; D011188:Potassium