Isolation of a tumor factor responsible for angiogenesis.
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.
D000818:Animals; D001808:Blood Vessels / Q000254:growth & development*; D002196:Capillaries / Q000254:growth & development; D002279:Carcinoma 256, Walker / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism; D008545:Melanoma / Q000378:metabolism; D051379:Mice; D008938:Mitosis; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism; D011506:Proteins; D012313:RNA; D051381:Rats; D009396:Wilms Tumor / Q000378:metabolism
D011506:Proteins; D012313:RNA