Induction of carcinomas in the nasal cavity of rats by dioxane.
Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004147:Dioxins; D008113:Liver Neoplasms; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced; D051381:Rats
D004147:Dioxins