Specificity of action of adrenocorticotrophin in vitro on ascorbate transport in rat adrenal glands.
The inhibition of ascorbate transport by rat adrenal quarters in response to steroidogenesis in vitro was shown to be highly specific with respect to tissue, substrate and steroidogenic agent. The transport system in vitro is capable of net accumulation of ascorbate. The evidence is consistent with the conclusion that ascorbate ;depletion' in the adrenal gland is due to a specific block by corticoids of the uptake of ascorbate.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000311:Adrenal Glands / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000450:Aldosterone / Q000494:pharmacology; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001345:Autoradiography; D001693:Biological Transport, Active / Q000187:drug effects*; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D003345:Corticosterone / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D005998:Glycine / Q000378:metabolism; D007016:Hypophysectomy; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000494:pharmacology; D014176:Protein Biosynthesis; D011691:Puromycin / Q000494:pharmacology; D051381:Rats
D000227:Adenine Nucleotides; D000596:Amino Acids; D002247:Carbon Isotopes; D000450:Aldosterone; D011691:Puromycin; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D000242:Cyclic AMP; D001205:Ascorbic Acid; D005998:Glycine; D003345:Corticosterone