Genetic mapping of a murine leukemia virus-inducing locus of AKR mice.
The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus.
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D007065:Idoxuridine / Q000494:pharmacology; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000235:genetics; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009374:Neoplasms, Experimental / Q000235:genetics*; D010641:Phenotype; D014779:Virus Replication / Q000187:drug effects
D007065:Idoxuridine