D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.
1. An enzyme in extracts of mammalian tissues catalyses the hydrolysis of d-myoinositol 1:2-cyclic phosphate (an intermediary in the enzymic degradation of phosphatidylinositol) to produce d-myoinositol 1-phosphate. 2. The enantiomorph of the substrate is not attacked. 3. The pH optimum is about 8.1-8.3 and the reaction is stimulated by Mg(2+) ions. 4. Extracts from rat kidney cortex and medulla are very rich sources of the enzyme; brain, testis and small intestine contain intermediary activities, and other tissues contain very small amounts.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002417:Cattle; D002854:Chromatography, Paper; D004586:Electrophoresis; D006863:Hydrogen-Ion Concentration; D007294:Inositol; D007421:Intestine, Small / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009943:Organophosphorus Compounds; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis*; D010759:Phosphorus Isotopes; D051381:Rats; D013552:Swine; D013737:Testis / Q000201:enzymology; D014020:Tissue Extracts
D009943:Organophosphorus Compounds; D010759:Phosphorus Isotopes; D014020:Tissue Extracts; D007294:Inositol; D010744:Phosphoric Monoester Hydrolases; D008274:Magnesium