Membrane structure: lipid-protein interactions in microsomal membranes.
The relationships of phospholipid to membrane structure and function were examined in hepatic microsomes. Findings indicate that normal microsomal membrane structure is dependent on lipid-protein interactions and that it correlates closely with glucose-6-phosphatase activity. Modification of most phospholipid with phospholipase-C is associated with widening of the membrane which can be reversed following readdition of phospholipid.
D000818:Animals; D003720:Densitometry; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D010740:Phospholipases / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats
D010743:Phospholipids; D010740:Phospholipases; D005952:Glucose-6-Phosphatase