Divergent biological effects of adenosine and dibutyryl adenosine 3',5'-monophosphate on the isolated fat cell.
Adenosine 3',5'-monophosphate stimulated production of carbon dioxide and lipid from glucose, whereas its dibutyryl derivative inhibited this conversion. Addition of the dibutyryl derivative to the isolated fat cell further stimulated lipolysis induced by adrenocorticotropic hormone, whereas addition of adenosine 3',5'-monophosphate inhibited this lipolysis. Hence, measured by these two parameters, the biologic properties of adenosine 3',5'-monophosphate and its dibutyryl derivative are distinctly different.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D003864:Depression, Chemical; D004357:Drug Synergism; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D008053:Lipid Mobilization / Q000187:drug effects; D008055:Lipids / Q000096:biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D014280:Triglycerides / Q000378:metabolism
D000227:Adenine Nucleotides; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D002245:Carbon Dioxide; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D005947:Glucose; D005990:Glycerol