A pressor substance in the cerebrospinal fluid of normotensive and hypertensive patients.
A pressor polypeptide was isolated from the cerebrospinal fluid of normotensive and hypertensive patients. Pharmacologically it behaves like angiotensin I. A very significant correlation (r = 0.83, P < 0.001) was found between the concentration of this polypeptide and the blood pressure of essential hypertensive patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000804:Angiotensin II / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000134:cerebrospinal fluid*; D006974:Hypertension, Malignant / Q000134:cerebrospinal fluid; D007082:Ileum / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D011863:Radioimmunoassay; D051381:Rats; D014599:Uterus / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000134:cerebrospinal fluid* / Q000302:isolation & purification / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D000804:Angiotensin II