Amino acid neurotransmitter candidates: sodium-dependent high-affinity uptake by unique synaptosomal fractions.
Glutamic and aspartic acids and glycine are accumulated by high-affinity uptake systems into synaptosomal preparations in central nervous tissue. Sodium is required by these high-affinity transports, but not by the low-affinity transports for these and other amino acids. The sodium-requiring amino acid uptake systems label unique synaptosomal fractions. Observations suggest that these amino acids serve specific synaptic functions, presumably as neurotransmitters.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001120:Arginine / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D002247:Carbon Isotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000494:pharmacology*; D013116:Spinal Cord / Q000378:metabolism*; D009435:Synaptic Transmission; D013572:Synaptic Vesicles / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism; D014316:Tritium
D000596:Amino Acids; D002247:Carbon Isotopes; D005971:Glutamates; D014316:Tritium; D001224:Aspartic Acid; D001120:Arginine; D012964:Sodium; D007930:Leucine; D005998:Glycine