Degradation of angiotensin II by plasmin.
1. Synthetic angiotensin II (Hypertensin, Ciba, Basel) was incubated with a water-insoluble preparation of plasmin (E.C. 3.4.4.14) and the resulting products analysed by paper chromatography and N-terminal amino-acid analysis.2. Only the N-terminal asparagine was split off from the peptide. This indicates that plasmin attacks the Asn-Arg but not the Arg-Val in angiotensin II molecule.
D000596:Amino Acids / Q000032:analysis; D000804:Angiotensin II / Q000378:metabolism*; D002854:Chromatography, Paper; D010450:Endopeptidases / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D013820:Thermolysin / Q000378:metabolism
D000596:Amino Acids; D000804:Angiotensin II; D010450:Endopeptidases; D005341:Fibrinolysin; D013820:Thermolysin