title: Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide.
abstract: Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A(O), A(2), and B viruses and parainfluenza 1 virus. infections is also effective.
mesh_terms: D000256:Adenoviridae / Q000187:drug effects; D000577:Amides / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects; D004267:DNA Viruses / Q000187:drug effects*; D005622:Friend murine leukemia virus / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000187:drug effects; D017955:Poliovirus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects*; D011817:Rabbits; D011820:Rabies virus / Q000187:drug effects; D018108:Respirovirus / Q000187:drug effects; D012229:Rhinovirus / Q000187:drug effects; D012263:Ribonucleosides / Q000494:pharmacology / Q000627:therapeutic use; D012672:Semliki forest virus / Q000187:drug effects; D014230:Triazoles / Q000494:pharmacology; D014616:Vaccinia virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D000577:Amides; D000998:Antiviral Agents; D009705:Nucleosides; D012263:Ribonucleosides; D014230:Triazoles