title: Demonstration of biological activity of a murine leukemia virus of New Zealand black mice.
abstract: Although New Zealand Black mouse embryo and adult tissues show evidence of murine leukemia viral particles and antigens, efforts to demonstrate biological activity of a murine leukemia virus by standard methods have proved negative. Cocultivation of tissues of these mice with non-virus-yielding hamster cells transformed by Moloney sarcoma virus, however, has resulted in the rescue of a pseudotype sarcoma virus, presumably carrying the New Zealand Black mouse leukemia virus coat. This virus has an unusual host restriction, producing foci of cell alteration only in rat cells.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D002460:Cell Line; D006224:Cricetinae; D046508:Culture Techniques; D004622:Embryo, Mammalian / Q000166:cytology; D009052:Leukemia Virus, Murine / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D008979:Moloney murine leukemia virus; D051381:Rats; D014776:Virus Cultivation