title: Two cases of "pancreatic cholera" with features of peptide-secreting adenomatosis of the pancreas.
abstract: The clinical data are presented of two women with profound metabolic upset from exceptional water and electrolyte losses in diarrhoea. One had an islet-cell adenoma of the pancreas and the other abnormal islets. Gastric and pancreatic function were abnormal in both, consistent with the subsequent demonstration of a pancreatic and choleretic secretagogue in the tumour tissue and pancreatic and gastric secretagogues in circulating blood (Cleator, Thomson, Sircus, and Coombes, 1970).
mesh_terms: D007516:Adenoma, Islet Cell / Q000175:diagnosis*; D000328:Adult; D003967:Diarrhea / Q000150:complications; D005260:Female; D005755:Gastrins / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D007010:Hyponatremia / Q000150:complications; D007515:Islets of Langerhans / Q000473:pathology; D010179:Pancreas / Q000378:metabolism; D010182:Pancreatic Diseases / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000601:surgery; D010455:Peptides / Q000378:metabolism*; D011877:Radionuclide Imaging; D014882:Water-Electrolyte Balance
chemical_list: D005755:Gastrins; D010455:Peptides