Comparison between the polymyxins and gentamicin in preventing endotoxin-induced intravascular coagulation and leukopenia.
Three antimicrobial agents were evaluated as to their ability to neutralize the toxic effects of endotoxin in rabbits. These consisted of two cyclic polypeptides, polymyxin B sulfate and colymycin M (sodium colistimethate), and an aminoglycoside, gentamicin sulfate. Polymyxin B regularly prevented endotoxin-induced leukopenia, thrombocytopenia, and disseminated intravascular coagulation. Colymycin M had similar activity but was not as effective as polymyxin B. Gentamicin demonstrated no neutralizing ability in this study.
D000818:Animals; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000517:prevention & control*; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D007673:Kidney Cortex Necrosis / Q000139:chemically induced; D007970:Leukopenia / Q000139:chemically induced / Q000517:prevention & control*; D011113:Polymyxins / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012790:Shwartzman Phenomenon; D013921:Thrombocytopenia / Q000139:chemically induced
D004731:Endotoxins; D005839:Gentamicins; D011113:Polymyxins; D003091:Colistin