Cyclic adenosine monophosphate stimulation of axonal elongation.
Elevated concentrations of adenosine 3',5'-monophosphate induce a variety of cell movements. The role of adenosine 3',5'-monophosphate in promoting those movements associated with growth prompted our study of in vitro microtubule-dependent axonal elongation. Ganglia treated with adenosine 5'-monophosphate show no enhancement over controls; treatment with adenosine 3', 5'monophosphate or its dibutyryl derivative significantly enhances elongation, as measured by increases in both axonal numbers and length. Our study suggests that adenosine 3',5'-monophosphate promotes elongation by stimulation of microtubule assembly.
D000818:Animals; D001369:Axons / Q000166:cytology / Q000187:drug effects / Q000196:embryology / Q000254:growth & development*; D002452:Cell Count; D002642:Chick Embryo; D000242:Cyclic AMP / Q000494:pharmacology*; D005724:Ganglia / Q000196:embryology / Q000254:growth & development*; D066298:In Vitro Techniques; D013268:Stimulation, Chemical
D000242:Cyclic AMP