title: Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N)-heterocyclic aldehyde thiosemicarbazones.
mesh_terms: D000818:Animals; D001665:Binding Sites; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000378:metabolism; D003597:Cytosine Nucleotides; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005557:Formaldehyde / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D008113:Liver Neoplasms; D009374:Neoplasms, Experimental / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011485:Protein Binding; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D012510:Sarcoma 180 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
chemical_list: D003597:Cytosine Nucleotides; D004273:DNA, Neoplasm; D007546:Isoquinolines; D011725:Pyridines; D013882:Thiosemicarbazones; D014316:Tritium; D005557:Formaldehyde; D009713:Nucleotidyltransferases; D013936:Thymidine