Biological effects of Corynebacterium parvum. 3. Amplification of resistance and impairment of active immunity to murine tumours.
The effect of pre-treatment with Corynebacterium parvum on the growth in vivo of a range of experimental mouse tumours with differing characteristics has been investigated. Varying degrees of protection were observed which were generally greater with the more immunogenic tumours. Administration of C. parvum 7 days before immunization with irradiated tumour cells diminished the protective effect which could be obtained by immunization alone. The possible basis for these seemingly conflicting influences is considered.
D000276:Adjuvants, Immunologic; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control; D003352:Corynebacterium / Q000276:immunology*; D005354:Fibrosarcoma / Q000517:prevention & control; D007110:Immunity, Active; D007114:Immunization; D007165:Immunosuppression Therapy; D007942:Leukemia, Experimental / Q000517:prevention & control; D007953:Leukemia, Radiation-Induced / Q000517:prevention & control; D008113:Liver Neoplasms / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000276:immunology / Q000517:prevention & control*; D010954:Plasmacytoma / Q000517:prevention & control; D011425:Propionibacterium acnes / Q000276:immunology
D000276:Adjuvants, Immunologic