title: Angiotensin and renin in rat and dog brain.
abstract: An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog.
mesh_terms: D000804:Angiotensin II / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D003377:Countercurrent Distribution; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D012083:Renin / Q000032:analysis*
chemical_list: D000804:Angiotensin II; D012083:Renin; D009638:Norepinephrine