Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents.
Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D005347:Fibroblasts / Q000382:microbiology; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000097:blood; D007739:L Cells; D051379:Mice; D009522:Newcastle disease virus / Q000276:immunology; D011070:Poly I-C / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C