Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone.
A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7-oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E(1), prostaglandin E(2), and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5'-monophosphate formation and steroidogenesis.
D000225:Adenine / Q000378:metabolism; D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000818:Animals; D002247:Carbon Isotopes; D000242:Cyclic AMP / Q000096:biosynthesis; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D007986:Luteinizing Hormone / Q000494:pharmacology*; D051379:Mice; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D011955:Receptors, Drug; D013268:Stimulation, Chemical
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011955:Receptors, Drug; D007986:Luteinizing Hormone; D000242:Cyclic AMP; D000225:Adenine