Type C virus from cell cultures of chemically induced rat hepatomas.
Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this compound were deficient in DNA polymerase activity.
D000818:Animals; D001354:Avian Leukosis Virus / Q000378:metabolism; D001973:Bromodeoxyuridine / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000382:microbiology*; D002478:Cells, Cultured; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D003854:Deoxyribonucleotides / Q000378:metabolism; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005449:Fluorenes; D008113:Liver Neoplasms / Q000139:chemically induced / Q000382:microbiology*; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental / Q000382:microbiology; D009858:Oncogenic Viruses / Q000254:growth & development*; D012328:RNA Viruses / Q000254:growth & development*; D012367:RNA, Viral / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D012190:Retroviridae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D003854:Deoxyribonucleotides; D005449:Fluorenes; D012367:RNA, Viral; D014316:Tritium; D004254:DNA Nucleotidyltransferases; D001973:Bromodeoxyuridine; D014529:Uridine; D004121:Dimethyl Sulfoxide