Effect of prostaglandin E 1  on certain renal actions of parathyroid hormone.
Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes; D000242:Cyclic AMP / Q000378:metabolism / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects*; D007672:Kidney Cortex / Q000187:drug effects / Q000502:physiology; D007684:Kidney Tubules / Q000502:physiology; D008297:Male; D008722:Methods; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis; D010759:Phosphorus Isotopes; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D002247:Carbon Isotopes; D010281:Parathyroid Hormone; D010710:Phosphates; D010743:Phospholipids; D010759:Phosphorus Isotopes; D011453:Prostaglandins; D000242:Cyclic AMP; D000262:Adenylyl Cyclases