title: Lack of significant oncogenicity of biological products in hamsters.
abstract: A variety of biological products which included live and inactivated viral vaccines, inactivated rickettsial and bacterial vaccines, toxoids, and a multiple bacterial antigen product did not appear to be oncogenic for newborn hamsters following a single subcutaneous inoculation. The incidence of spontaneous tumors was approximately 4.7%, and this figure was not significantly altered by the inoculation of any of the test materials.
mesh_terms: D000236:Adenoma / Q000139:chemically induced; D000256:Adenoviridae; D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D000831:Animals, Newborn; D000942:Antigens, Bacterial / Q000009:adverse effects; D001428:Bacterial Vaccines / Q000009:adverse effects; D001688:Biological Products / Q000009:adverse effects*; D002273:Carcinogens; D006224:Cricetinae / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009928:Organ Specificity; D011247:Pregnancy; D013539:Simian virus 40; D014121:Toxoids / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D001688:Biological Products; D002273:Carcinogens; D014121:Toxoids; D014765:Viral Vaccines