Inhibitors of DNA polymerases of murine leukemia viruses: activity of ethidium bromide.
Ethidium bromide, compared on a molar basis, was a more effective inhibitor of the DNA polymerases of the Rauscher and Moloney murine leukemia viruses than either 4-N-demethylrifampicin or 4-N-benzyldemethylrifampicin. Daunomycin inhibited the polymerases weakly, and chromomycin A(3) inhibited almost not at all. 4-N-Benzyldemethylrifampicin was a more active inhibitor than the 4-N-demethyl congener.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D003630:Daunorubicin / Q000494:pharmacology*; D003902:Detergents / Q000494:pharmacology; D004357:Drug Synergism; D009052:Leukemia Virus, Murine / Q000187:drug effects* / Q000201:enzymology*; D009711:Nucleotides / Q000378:metabolism; D010617:Phenanthridines / Q000494:pharmacology*; D051381:Rats; D012293:Rifampin / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003902:Detergents; D009711:Nucleotides; D010617:Phenanthridines; D004254:DNA Nucleotidyltransferases; D013936:Thymidine; D012293:Rifampin; D003630:Daunorubicin