The effect of acute administration of (meta trifluoro methyl-phenyl)-1-(benzoyl oxy) ethyl amino-2-propane (780 SE) and fenfluramine on human sleep.
In contrast to other amphetamine derivatives, fenfluramine (40 mg) and 780 SE (300 mg) had no effect on the rapid eye movement (REM) phase of sleep. Like other amphetamines they disturbed sleep, increasing the number of shifts to stage 1 (drowsiness) and stage W (arousal).
D000328:Adult; D000661:Amphetamine / Q000494:pharmacology; D001067:Appetite Depressants / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology; D005461:Fluorine / Q000494:pharmacology; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D011437:Propylamines / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D012894:Sleep Stages; D012895:Sleep, REM / Q000187:drug effects*
D001067:Appetite Depressants; D010627:Phenethylamines; D011437:Propylamines; D005461:Fluorine; D005277:Fenfluramine; D000661:Amphetamine