Hydrocephalus in mice inoculated neonatally by the oronasal route with reovirus type 1.
Mice inoculated neonatally by the oronasal route with reovirus type 1 or 2 developed typical acute disease. Fifteen percent of the mice recovered from the acute infection. No further disease was noted in mice infected with reovirus 2, but 9 percent of the survivors of reovirus I infections developed hydrocephalus at a mean time of 109 days after inoculation. Infectious virus could not be isolated from hydrocephalic mice.
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000473:pathology; D003588:Cytopathogenic Effect, Viral; D006849:Hydrocephalus / Q000209:etiology* / Q000473:pathology; D007739:L Cells; D051379:Mice; D012087:Reoviridae / Q000472:pathogenicity; D012088:Reoviridae Infections / Q000150:complications*