title: Transfer of interferon-producing macrophages: new approach to viral chemotherapy.
abstract: Mice were protected from infection with Semliki Forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. This method of therapy was also utilized in animals infected with encephalomy-ocarditis virus after onset of clinical signs. Of these animals 40 percent recovered, but only 9 percent of the control group recovered.
mesh_terms: D000818:Animals; D002646:Chikungunya virus; D046508:Culture Techniques; D004686:Encephalomyocarditis virus / Q000276:immunology; D007372:Interferons / Q000096:biosynthesis*; D008264:Macrophages / Q000637:transplantation*; D051379:Mice; D012672:Semliki forest virus / Q000276:immunology; D014184:Transplantation, Homologous; D014777:Virus Diseases / Q000401:mortality / Q000517:prevention & control*; D014779:Virus Replication
chemical_list: D007372:Interferons