Adenyl cyclase of cultured mammalian cells: activation by catecholamines.
Chang's liver cells and 3T6 mouse embryo fibroblasts contain high amounts of catecholamine-sensitive adenyl cyclase, whereas HeLa cells contain relatively low amounts of activity. Both epinephrine and fluoride ion stimulate activity of each cell line. In contrast to normal liver, Chang's liver cells show greater response to epinephrine and no detectable stimulation by glucagon.
D000227:Adenine Nucleotides; D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D002415:Cats; D046508:Culture Techniques; D000242:Cyclic AMP / Q000032:analysis; D004789:Enzyme Activation; D004798:Enzymes / Q000032:analysis*; D004837:Epinephrine / Q000494:pharmacology*; D005347:Fibroblasts; D005934:Glucagon / Q000494:pharmacology; D006367:HeLa Cells; D008099:Liver / Q000201:enzymology; D051379:Mice; D010759:Phosphorus Isotopes; D051381:Rats
D000227:Adenine Nucleotides; D004798:Enzymes; D010759:Phosphorus Isotopes; D005934:Glucagon; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D004837:Epinephrine