title: Inhibition of vitamin K2 and carotenoid synthesis in Staphylococcus aureus by diphenylamine.
abstract: Diphenylamine at concentrations which did not effect the growth rate inhibited the synthesis of vitamin K(2) in both anaerobic and aerobic cultures by about 50%. At this concentration, diphenylamine inhibited the synthesis of the cyclic carotenoids delta-carotene and the rubixanthins 25 to 35% anaerobically and 60 to 90% aerobically. The inhibition of synthesis of cyclic carotenoids and vitamin K(2) by diphenylamine had no detectable effect on the formation of the membrane-bound electron transport system.
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology*; D002247:Carbon Isotopes; D002338:Carotenoids / Q000096:biosynthesis*; D002462:Cell Membrane / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003470:Culture Media; D003580:Cytochromes / Q000096:biosynthesis; D003864:Depression, Chemical; D004579:Electron Transport; D005782:Gels; D006418:Heme / Q000096:biosynthesis; D008798:Mevalonic Acid / Q000378:metabolism; D010100:Oxygen; D010101:Oxygen Consumption; D010743:Phospholipids / Q000096:biosynthesis; D011048:Polarography; D012822:Silicon Dioxide; D013053:Spectrophotometry; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D014812:Vitamin K / Q000096:biosynthesis*
chemical_list: D000814:Aniline Compounds; D002247:Carbon Isotopes; D003470:Culture Media; D003580:Cytochromes; D005782:Gels; D010743:Phospholipids; D014812:Vitamin K; D002338:Carotenoids; D006418:Heme; D012822:Silicon Dioxide; D008798:Mevalonic Acid; D010100:Oxygen