Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus.
A surface receptor for an agglutinin, exposed in transformed but not in normal cells, arises in normal mouse cells during lytic infection by polyoma virus. The structural change in the surface membrane characteristic of transformed cells and of cells productively infected by wild type virus fails to occur in normal mouse cells infected by mutants of the virus that are unable to cause transformation. The exposure of the receptor site by wild type virus is reversibly blocked by inhibitors of DNA synthesis.
D000372:Agglutination Tests; D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane; D002471:Cell Transformation, Neoplastic; D003208:Concanavalin A; D003260:Contact Inhibition; D004247:DNA / Q000096:biosynthesis; D006241:Haptens; D007668:Kidney; D037102:Lectins; D051379:Mice; D009154:Mutation; D011120:Polyomavirus / Q000528:radiation effects; D011691:Puromycin / Q000494:pharmacology; D011830:Radiation Effects; D014466:Ultraviolet Rays
D006241:Haptens; D037102:Lectins; D003208:Concanavalin A; D011691:Puromycin; D004247:DNA