title: Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma.
abstract: Sera from 14 normal subjects and 43 patients with colonic carcinoma were evaluated for the presence of carcinoembryonic antigen (CEA). Inhibiting material which behaved in the assay in a similar manner to CEA was found in normal serum at concentrations below 2.8 ng/ml. Its nature has not so far been established. Thirty-eight of the 43 patients with colonic carcinoma showed levels of serum CEA in excess of 2.8 ng/ml. The concentration of CEA in serum was correlated with the extent of the disease as classified by a staging procedure similar to that of Dukes (1932). Examination of a small number of specimens of colonic carcinoma and normal colonic mucosa suggested that the concentration of CEA in different adenocarcinomata may vary, and that traces of cross-reacting material may be found in some normal mucosae.
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology; D000941:Antigens / Q000032:analysis*; D003106:Colon / Q000276:immunology; D003110:Colonic Neoplasms / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D010472:Perchlorates; D011863:Radioimmunoassay
chemical_list: D000941:Antigens; D010472:Perchlorates