Effect of poly I: C on experimental respiratory infection in hamsters.
The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 mug/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced the virus yields taken 28 hr after infection. Deep intranasal and intraperitoneal treatment with poly I:C greatly decreased the virus titers in the lungs, as measured 48 hr after a deep lung infection with parainfluenza 3 virus; however, the upper respiratory poly I:C treatment was ineffective.
D000818:Animals; D006224:Cricetinae; D003597:Cytosine Nucleotides / Q000008:administration & dosage*; D004304:Dosage Forms; D007274:Injections, Intraperitoneal; D008168:Lung / Q000382:microbiology; D008297:Male; D009666:Nose / Q000382:microbiology; D009705:Nucleosides / Q000008:administration & dosage; D018184:Paramyxoviridae Infections / Q000382:microbiology / Q000517:prevention & control*; D011119:Polynucleotides / Q000008:administration & dosage*; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000517:prevention & control*; D018108:Respirovirus / Q000187:drug effects / Q000302:isolation & purification; D013223:Statistics as Topic
D003597:Cytosine Nucleotides; D004304:Dosage Forms; D009705:Nucleosides; D011119:Polynucleotides