Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n  strains of mice.
AKR mice, which regularly contain infectious murine leukemia virus, were mated with four Fv-1(n) strains of mice which show little or no expression of virus. F(1), F(2), and first and second backcross generation hybrids were tested for virus in tail tissue at 2 and 6 wk of age. The segregation data indicate that the AKR mouse contains two unlinked, autosomal, chromosomal loci, either of which suffices to induce detectable levels of infectious virus in Fv-1(n) progeny by 6 wk of age. One of the loci (tentatively referred to as V(1)) is on linkage group I, 25-30 map units from the locus for albino; the gene order tentatively appears to be N(1)-c-Hbb.
D000818:Animals; D003433:Crosses, Genetic; D046508:Culture Techniques; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006824:Hybridization, Genetic; D009052:Leukemia Virus, Murine; D007942:Leukemia, Experimental / Q000235:genetics* / Q000382:microbiology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains