Inhibition of cleavage of large poliovirus-specific precursor proteins in infected HeLa cells by inhibitors of proteolytic enzymes.
Inhibitors of chymotrypsin interfere with the post-translational cleavage of large poliovirus-specific polypeptides in the molecular weight range of 100,000 to 250,000 in infected HeLa cells.
D001345:Autoradiography; D002247:Carbon Isotopes; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D004591:Electrophoresis, Polyacrylamide Gel; D005827:Genetics, Microbial; D006367:HeLa Cells / Q000378:metabolism*; D006801:Humans; D007659:Ketones / Q000494:pharmacology*; D008715:Methionine / Q000378:metabolism; D008970:Molecular Weight; D010452:Peptide Biosynthesis; D010455:Peptides / Q000032:analysis; D017955:Poliovirus / Q000032:analysis / Q000254:growth & development / Q000378:metabolism*; D014176:Protein Biosynthesis; D013237:Stereoisomerism; D013460:Sulfur Isotopes; D014361:Trypsin Inhibitors / Q000494:pharmacology*; D014529:Uridine / Q000378:metabolism; D014764:Viral Proteins / Q000032:analysis / Q000096:biosynthesis*
D002247:Carbon Isotopes; D007659:Ketones; D010455:Peptides; D013460:Sulfur Isotopes; D014361:Trypsin Inhibitors; D014764:Viral Proteins; D008715:Methionine; D002918:Chymotrypsin; D014529:Uridine