Hemopoietic colony-forming cell responses in mice infected with ectromelia virus.
The responses of in vitro colony-forming cells (granulocyte-macrophage progenitor cells) were studied in the bone marrow, spleen, and blood of mice after intraperitoneal injection of 10(3) plaque-forming units of ectromelia virus. This study showed that a colony-forming cell response occurred during infection and was accompanied by an increase in the serum level of colony-stimulating factor and, at a later stage, colony-inhibiting factor. Changes in the proportions of colony-forming cells were not due to relative changes in other cell populations. The relationships between colony-forming cell responses and levels of infection were complex, higher levels of infection being associated with good colony-forming cell responses in bone marrow and apparently poor colony-forming cell responses in blood and spleen.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D002455:Cell Division; D002999:Clone Cells / Q000276:immunology; D004481:Ectromelia virus / Q000254:growth & development / Q000276:immunology*; D005260:Female; D007372:Interferons; D007739:L Cells / Q000276:immunology; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011213:Poxviridae Infections / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D007372:Interferons