Pituitary peptides and the suppression of memory by puromycin.
It has previously been shown that the expression of memory of maze-learning in mice is blocked by intracerebrally-injected puromycin one or more days after the training experience, and that bilateral adrenalectomy before training protects memory against this effect of puromycin. Purified cortrophin gel, injected subcutaneously up to 3 days before training, has now been found to give results like those obtained with adrenalectomy and, additionally, to provide a high degree of protection when injected up to 16 hr after training. Several possible explanations for these effects have been considered and found to be inadequate.
D000315:Adrenalectomy; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001921:Brain; D005260:Female; D005782:Gels; D007267:Injections; D007279:Injections, Subcutaneous; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D011691:Puromycin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D005782:Gels; D011691:Puromycin; D000324:Adrenocorticotropic Hormone