title: Comparative studies of plaque variantes derived from a Florida strain of Venezuelan equine encephlomyelitis virus.
abstract: Small- and large-plaque variants of a Florida strain (Fe 3-7c) of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small-plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed.
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology; D002130:Calcium Phosphates; D002845:Chromatography; D006224:Cricetinae; D004683:Encephalomyelitis, Equine / Q000276:immunology*; D004686:Encephalomyocarditis virus / Q000276:immunology*; D014644:Genetic Variation; D006168:Guinea Pigs / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D007106:Immune Sera; D005779:Immunodiffusion; D007928:Lethal Dose 50; D051379:Mice; D009500:Neutralization Tests; D014774:Virulence
chemical_list: D002130:Calcium Phosphates; D007106:Immune Sera