Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma.
Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known.
D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001623:Betamethasone / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011279:Pregnanetriol / Q000008:administration & dosage* / Q000378:metabolism; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D000336:Aerosols; D011279:Pregnanetriol; D000324:Adrenocorticotropic Hormone; D001623:Betamethasone; D011239:Prednisolone; D006854:Hydrocortisone