Inhibition of cyclic 3',5'-adenosine monophosphate phosphodiesterase by substituted imidazopyrazines.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology; D002247:Carbon Isotopes; D002417:Cattle; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010179:Pancreas / Q000201:enzymology; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D011719:Pyrazines / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013329:Structure-Activity Relationship; D013806:Theophylline / Q000494:pharmacology; D014599:Uterus / Q000201:enzymology; D014665:Vasodilator Agents / Q000494:pharmacology
D001993:Bronchodilator Agents; D002247:Carbon Isotopes; D007093:Imidazoles; D011719:Pyrazines; D014665:Vasodilator Agents; D013806:Theophylline; D000242:Cyclic AMP; D010744:Phosphoric Monoester Hydrolases; D000262:Adenylyl Cyclases; D005990:Glycerol; D009638:Norepinephrine