title: Effect of pyrrolnitrin on electron transport and oxidative phosphorylation in mitochondria isolated from Neurospora crassa.
abstract: Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase.
mesh_terms: D000814:Aniline Compounds / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D000968:Antimycin A / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D004566:Electrodes; D004579:Electron Transport / Q000187:drug effects*; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000201:enzymology / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D010101:Oxygen Consumption; D013053:Spectrophotometry; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology*
chemical_list: D000814:Aniline Compounds; D000935:Antifungal Agents; D003486:Cyanides; D013386:Succinates; D014475:Uncoupling Agents; D009243:NAD; D000968:Antimycin A; D010088:Oxidoreductases; D013385:Succinate Dehydrogenase