Adenosine 3',5'-monophosphate increases capacity for RNA synthesis in rat liver nuclei.
Liver nuclei isolated from rats injected with adenosine 3', 5'-monophosphate exhibit an increased capacity for RNA synthesis compared with nuclei from control animals. This effect, which is highly specific for the cyclic nucleotide. can be observed within 1 hour after injection in both unoperated and adrenalectomized rats. These findings suggest that induction of enzyme synthesis mediated by way of adenosine 3', 5'-monophosphate may be controlled, at least in part, at the level of gene transcription.
D000227:Adenine Nucleotides / Q000494:pharmacology*; D000818:Animals; D002247:Carbon Isotopes; D002467:Cell Nucleus / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology; D004790:Enzyme Induction; D005815:Genetic Code; D007267:Injections; D008099:Liver / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D012313:RNA; D000242:Cyclic AMP