Effect of pyrrolnitrin on electron transport and oxidative phosphorylation in mitochondria isolated from Neurospora crassa.
Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase.
D000814:Aniline Compounds / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D000968:Antimycin A / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D004566:Electrodes; D004579:Electron Transport / Q000187:drug effects*; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000201:enzymology / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D010101:Oxygen Consumption; D013053:Spectrophotometry; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology*
D000814:Aniline Compounds; D000935:Antifungal Agents; D003486:Cyanides; D013386:Succinates; D014475:Uncoupling Agents; D009243:NAD; D000968:Antimycin A; D010088:Oxidoreductases; D013385:Succinate Dehydrogenase