Homologies in amino acid composition and structure of histone F2al isolated from human leukaemic cells.
Histones F2al extracted from normal and neoplastic cells possess similar amino acid compositions. Tryptic and chymotryptic peptides of the F2al histones have identical chromato-electrophoretic R(F) values. It is concluded that histones F2al from various sources have similar overall structures. The observed differences in the ratios of in-N-monomethyl- and di-in-N-methyl-lysine in the histones from normal and neoplastic cells may be of significance with respect to gene regulation.
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002417:Cattle; D002460:Cell Line; D002845:Chromatography; D002850:Chromatography, Gel; D002918:Chymotrypsin; D003486:Cyanides; D004589:Electrophoresis, Disc; D006657:Histones / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008113:Liver Neoplasms; D008228:Lymphoma, Non-Hodgkin / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000378:metabolism; D013950:Thymus Gland / Q000032:analysis; D014357:Trypsin
D000596:Amino Acids; D003486:Cyanides; D006657:Histones; D002918:Chymotrypsin; D014357:Trypsin