Fine structure of an oat cell carcinoma of the lung associated with ectopic ACTH syndrome.
Electron-microscopic examination of an oat-cell carcinoma associated with the ectopic ACTH syndrome demonstrated characteristic cytoplasmic granules of 60-240 nm. diameter, consisting of a dense central core separated by a clear halo from an outer investing membrane. Comparison with previously examined non-secretory oat-cell carcinomas showed the granules to be more numerous in the present case. They are considered to represent secretory activity in the tumour.
D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000378:metabolism / Q000473:pathology*; D003594:Cytoplasmic Granules; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008566:Membranes; D008854:Microscopy, Electron; D008875:Middle Aged
D000324:Adrenocorticotropic Hormone