title: Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene.
abstract: The hisT gene, one of six genes in which mutation causes derepression of the histidine operon in Salmonella typhimurium, is shown to code for a protein that is not essential for the growth of the bacteria. This is indicated by the characterization of particular classes of mutations in the hisT gene: amber mutations, frame-shift mutations, and temperature-sensitive mutations that affect repression but not growth. In addition, the class of semilethal mutations was selected for but not found.
mesh_terms: D000409:Alanine; D001426:Bacterial Proteins; D002874:Chromosome Mapping; D003470:Culture Media; D004794:Enzyme Repression; D005809:Genes, Regulator; D005827:Genetics, Microbial; D006639:Histidine / Q000096:biosynthesis*; D009153:Mutagens; D009154:Mutation; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011796:Quinacrine; D012483:Salmonella Phages; D012486:Salmonella typhimurium / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D013489:Suppression, Genetic; D013696:Temperature; D014161:Transduction, Genetic; D014230:Triazoles
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D009153:Mutagens; D014230:Triazoles; D006639:Histidine; D010744:Phosphoric Monoester Hydrolases; D011796:Quinacrine; D000409:Alanine