Co-infection of mouse spleen cells with murine sarcoma virus and Guaroa virus.
Enhancement of tumor induction by oncornaviruses through a dual viral infection has been described by several investigators. The mechanism(s) of this enhancement has not as yet been determined. By using a murine sarcoma virus and a Bunyawera group arbovirus (Guaroa virus) in an in vitro system, evidence was obtained for enhancement of the oncogenic potential of the viruses by genetic interaction with the nononcogenic virus as well as the production of increased amounts of the oncogenic virus. These results confirm and extend similar responses obtained in in vivo systems.
D000327:Adsorption; D000818:Animals; D001103:Arboviruses / Q000254:growth & development* / Q000276:immunology / Q000302:isolation & purification; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured / Q000382:microbiology; D006224:Cricetinae; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D017988:Gammaretrovirus / Q000254:growth & development* / Q000302:isolation & purification; D005827:Genetics, Microbial; D000882:Haplorhini; D007106:Immune Sera; D007668:Kidney; D051379:Mice / Q000196:embryology; D008815:Mice, Inbred Strains; D008979:Moloney murine leukemia virus / Q000276:immunology; D009500:Neutralization Tests; D009858:Oncogenic Viruses / Q000254:growth & development; D013154:Spleen; D014776:Virus Cultivation
D007106:Immune Sera