Effect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice.
The effect of neonatal infection with Friend virus (FV) and Rowson-Parr virus (RPV) on the maturation of the capacity to respond to sheep red cells, as measured by the numbers of hemolytic plaque-forming cells in the spleen, was investigated in BALB/c mice. Both viruses affected immunological maturation but there were significant differences between their effects. The development with age of the ability to produce plaque-forming cells in response to antigen was virtually abolished by FV and only slightly impaired by RPV. Furthermore, FV also suppressed the development of background plaque-forming cells, whereas RPV did not.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000914:Antibodies, Viral; D000917:Antibody Formation; D000956:Antigens, Viral; D001835:Body Weight; D004912:Erythrocytes / Q000276:immunology; D005622:Friend murine leukemia virus / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D009052:Leukemia Virus, Murine / Q000302:isolation & purification; D008223:Lymphoma / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000254:growth & development / Q000276:immunology; D009858:Oncogenic Viruses / Q000276:immunology*; D009929:Organ Size; D012526:Satellite Viruses / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral