Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses.
Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA-containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002848:Chromatography, DEAE-Cellulose; D003168:Complement Fixation Tests; D004254:DNA Nucleotidyltransferases / Q000037:antagonists & inhibitors*; D007122:Immunoelectrophoresis; D009052:Leukemia Virus, Murine / Q000201:enzymology*; D008979:Moloney murine leukemia virus / Q000276:immunology; D009368:Neoplasm Transplantation; D012367:RNA, Viral; D051381:Rats; D011925:Rauscher Virus / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology; D013942:Thymine Nucleotides / Q000378:metabolism; D014316:Tritium
D000906:Antibodies; D012367:RNA, Viral; D013942:Thymine Nucleotides; D014316:Tritium; D004254:DNA Nucleotidyltransferases