title: Infection of genital tract and transmission of ocular infection to newborns by the agent of guinea pig inclusion conjunctivitis.
abstract: Female guinea pigs were inoculated intravaginally with the agent of guinea pig inclusion conjunctivitis (Gp-ic). Evidence for infection was obtained by demonstration of Gp-ic inclusions in epithelial cells of genital tract smears, histopathology, recovery of Gp-ic during infection, and antibody response. Infection of the genital tract was produced with low doses (20-200 median egg lethal doses) of the agent. The infection lasted about 3 weeks, and there was no marked clinical response. Ocular infection that could be detected as early as 3 days after birth in offspring of infected mothers was also demonstrated.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002642:Chick Embryo; D002689:Chlamydia / Q000302:isolation & purification*; D003235:Conjunctivitis, Inclusion / Q000276:immunology / Q000382:microbiology*; D004847:Epithelial Cells; D004848:Epithelium / Q000382:microbiology; D005128:Eye Diseases / Q000382:microbiology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005831:Genital Diseases, Female / Q000382:microbiology*; D006168:Guinea Pigs; D002479:Inclusion Bodies / Q000382:microbiology; D007928:Lethal Dose 50; D011247:Pregnancy; D013997:Time Factors; D014621:Vagina / Q000382:microbiology; D014626:Vaginal Smears
chemical_list: D000907:Antibodies, Bacterial