Invasive properties of histone transformed cells.
A technique was developed to study the invasion of cells into mouse kidney cortex in the presence of crude rat liver histone at a medium concentration of 100 μg./ml. A marked increase in the invasiveness of normal cells occurred in the presence of histone. Possible explanations of this phenomenon are discussed. The invasiveness was compared with that of cells previously transformed with polyoma virus.
D000818:Animals; D001853:Bone Marrow; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D006224:Cricetinae; D046508:Culture Techniques; D006657:Histones / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000166:cytology; D008099:Liver / Q000032:analysis; D011120:Polyomavirus; D051381:Rats; D013249:Sternum
D006657:Histones