Immunoglobulin production by human lymphocytoid lines and clones: absence of genic exclusion.
Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture.
D002460:Cell Line / Q000276:immunology / Q000378:metabolism; D002999:Clone Cells / Q000378:metabolism*; D046508:Culture Techniques; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D005779:Immunodiffusion; D007125:Immunogenetics; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007136:Immunoglobulins / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins