title: Virucidal activity of chlorhexidine on strains of Herpesvirus hominis, poliovirus, and adenovirus.
abstract: The infectivity titre of two strains of Herpesvirus hominis was reduced by not more than six log(10) units by 90 minutes' exposure to chlorhexidine at a final concentration of 0.02% at room temperature. Under identical conditions the compound was ineffective against a vaccine strain of poliovirus and against an adenovirus. Experimental conditions are described whereby the toxic effect of the disinfectant on the tissue culture assay systems are minimized.
mesh_terms: D000256:Adenoviridae / Q000187:drug effects*; D000818:Animals; D000998:Antiviral Agents; D001645:Biguanides / Q000494:pharmacology*; D002277:Carcinoma; D002460:Cell Line; D002642:Chick Embryo; D046508:Culture Techniques; D004202:Disinfectants / Q000494:pharmacology; D006801:Humans; D007822:Laryngeal Neoplasms; D017955:Poliovirus / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*; D013501:Surface-Active Agents / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D001645:Biguanides; D004202:Disinfectants; D013501:Surface-Active Agents