Adenosine 3',5'-monophosphate and N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate transport in cells.
Incubation of Strain L cells in 0.15 millimolar adenosine 3',5'-monophosphate (cyclic AMP) increase the intracellular level of cyclic AMP more than does incubation in dibutyryl cyclic AMP. The intracellular increase of cyclic AMP is greater with Strain L than with WI-38 cells. Similarly, cell division of Strain L cells is inhibited more by cyclic AMP. The experiments do not, support the belief that dibutyryl cyclic AMP is transported better than cyclic AMP.
D000818:Animals; D001692:Biological Transport; D002087:Butyrates / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002477:Cells / Q000378:metabolism*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D007739:L Cells / Q000032:analysis / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
D002087:Butyrates; D000242:Cyclic AMP