Nonproducing state of Rous sarcoma cells: its contagiousness in chicken cell cultures.
Nonproducing Rous sarcoma cells of the chicken were capable of transmitting the Rous sarcoma virus genome to neighboring chick embryo fibroblasts. This transfer required close proximity of sarcoma and normal cells and may have been mediated by a subcellular infectious agent which was found to be released from nonproducing cells.
D000818:Animals; D001354:Avian Leukosis Virus / Q000276:immunology*; D001358:Avian Sarcoma Viruses / Q000254:growth & development; D002471:Cell Transformation, Neoplastic; D002642:Chick Embryo; D046508:Culture Techniques; D003673:Defective Viruses; D005827:Genetics, Microbial; D006378:Helper Viruses; D001357:Sarcoma, Avian / Q000473:pathology*