Activity of ribosomes containing 5S RNA with a chemically modified 3'-terminus.
Ribosomes containing 5S RNA in which the 3'-terminus has been modified chemically, either by periodate oxidation or by conversion of the terminal ribose to a morpholine derivative, are fully as active in peptidebond formation and polypeptide synthesis as those ribosomes with unmodified 5S RNA. These results exclude models for protein synthesis in which peptidyl-5S RNA is formed as an intermediate.
D001407:Bacillus / Q000378:metabolism; D001894:Borohydrides; D008744:Methylamines; D010084:Oxidation-Reduction; D010452:Peptide Biosynthesis; D010442:Peptide Chain Initiation, Translational; D010504:Periodic Acid; D012335:RNA, Ribosomal / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001894:Borohydrides; D008744:Methylamines; D012335:RNA, Ribosomal; D010504:Periodic Acid