Studies on progressive metabolic alterations in thioacetamide induced hepatocarcinogenesis.
Sequential studies on levels of glycogen and lactic acid as well as activities of glucose-6-phosphatase, fructose-1, 6-diphosphatase aldolase, aspartic and ornithine transcarbamylase, arginase and xanthine oxidase were carried out in liver and tumour tissue of mice fed with 0.03% thioacetamide in normal stock diet. It was observed that significant decrease in glycogen content and activities of gluconeogenic enzymes was apparent at the age of 4 months, i.e. 2 months after thioacetamide treatment. Alterations in the other parameters studied were observed later, i.e. at the age of 9 months. Maximum changes were observed in the hepatomas, i.e. at the age of 17 months.
D000577:Amides; D000818:Animals; D001119:Arginase / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000378:metabolism*; D006597:Fructose-Bisphosphatase / Q000032:analysis; D005634:Fructose-Bisphosphate Aldolase / Q000032:analysis; D005952:Glucose-6-Phosphatase / Q000032:analysis; D007773:Lactates / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000032:analysis; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D009954:Ornithine Carbamoyltransferase / Q000032:analysis; D013438:Sulfhydryl Compounds; D014166:Transferases / Q000032:analysis; D014969:Xanthine Oxidase / Q000032:analysis
D000577:Amides; D007773:Lactates; D008112:Liver Glycogen; D013438:Sulfhydryl Compounds; D014969:Xanthine Oxidase; D014166:Transferases; D009954:Ornithine Carbamoyltransferase; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D001119:Arginase; D005634:Fructose-Bisphosphate Aldolase