Epithelial origin of polyoma salivary tumors in mice: evidence based on chromosome-marked cells.
Trypsin dissection of epithelium from mesenchyme of salivary gland rudiments allows reassembly of glands having either epithelium or mesenchyme selectively marked by T(6) chromosomes. Virus-induced tumors in such glands invariably bear the karyotype of the epithelial component. The method solves a specific example from a group of classical problems concerning epithelial as opposed to mesenchymal origin of neoplasms.
D000782:Aneuploidy; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002875:Chromosomes; D003582:Cytogenetics; D004622:Embryo, Mammalian; D005260:Female; D007621:Karyotyping; D008648:Mesoderm; D051379:Mice; D008938:Mitosis; D009374:Neoplasms, Experimental / Q000209:etiology; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D011120:Polyomavirus / Q000472:pathogenicity*; D011247:Pregnancy; D012468:Salivary Gland Neoplasms / Q000235:genetics*; D013363:Submandibular Gland / Q000196:embryology / Q000637:transplantation; D014357:Trypsin
D014357:Trypsin