Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes.
Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral / Q000096:biosynthesis; D002417:Cattle; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002875:Chromosomes / Q000473:pathology; D003168:Complement Fixation Tests; D003588:Cytopathogenic Effect, Viral; D005333:Fetus; D005347:Fibroblasts / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D000882:Haplorhini / Q000276:immunology*; D006564:Herpesviridae / Q000472:pathogenicity*; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D007106:Immune Sera; D007668:Kidney; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D010336:Pathology; D010920:Placenta
D000956:Antigens, Viral; D007106:Immune Sera