Structure and antischistosomal activity in the nitrofuran series. Requirement for a 5-nitro-2-furyl-vinyl moiety based on comparison of 3-(5-nitro-2-furyl)-substituted propionic, acrylic, and propiolic acid derivatives.
D000178:Acrylamides / Q000138:chemical synthesis / Q000627:therapeutic use; D000480:Alkynes / Q000138:chemical synthesis / Q000627:therapeutic use; D000577:Amides / Q000138:chemical synthesis / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009581:Nitrofurans / Q000138:chemical synthesis* / Q000627:therapeutic use; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D006005:Phosphorylases / Q000378:metabolism; D011422:Propionates / Q000138:chemical synthesis / Q000627:therapeutic use; D012552:Schistosomiasis / Q000188:drug therapy / Q000378:metabolism; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use
D000178:Acrylamides; D000480:Alkynes; D000577:Amides; D000871:Anthelmintics; D009581:Nitrofurans; D011422:Propionates; D014753:Vinyl Compounds; D006005:Phosphorylases; D010744:Phosphoric Monoester Hydrolases