Effect of staphylococcal alpha-toxin on the fine structure of pancreatic acinar cells of dogs.
Staphylococcal alpha-toxin induced pancreatitis in dogs was studied by electron microscopy. Pancreatic acinar cell injury was indicated by increased vesiculation of endoplasmic reticulum, loss of intracisternal granules, changes in mitochondria, membrane discontinuities and an increased number of dense complex bodies, lipid droplets and free ribosomes.
D000818:Animals; D003594:Cytoplasmic Granules; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006056:Golgi Apparatus; D002479:Inclusion Bodies; D008854:Microscopy, Electron; D010179:Pancreas / Q000166:cytology* / Q000187:drug effects; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology*; D013210:Staphylococcus; D014118:Toxins, Biological / Q000633:toxicity*
D014118:Toxins, Biological