A genetic locus for inducibility of C-type in BALB-c cells: the effect of a nonlinked regulatory gene on detection of virus after chemical activation.
Previous studies have shown that chemicals can transiently activate endogenous C-type viruses from embryo cells of the BALB/c mouse strain, but not from cells of another mouse strain, NIH Swiss. The number of genetic loci for inducibility of endogenous virus in BALB/c cells was investigated with cell lines derived from appropriate, F(1), F(2)-hybrid, and backcross generation embryos of these strains. A single genetic locus responsible for inducibility of virus in BALB/c cells was detected, and tentatively designated Ind. A second locus, previously described in studies of mouse-cell susceptibility to exogenous virus infection, Fv-1, was found to be genetically nonlinked to Ind. This regulatory gene plays an important role in determining whether the induced viruses of BALB/c cells can persist after chemical activation.
D000818:Animals; D002460:Cell Line; D003433:Crosses, Genetic; D046508:Culture Techniques; D003857:Deoxyuridine; D004622:Embryo, Mammalian; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D005815:Genetic Code; D005838:Genotype; D005865:Gestational Age; D006824:Hybridization, Genetic; D007455:Iodine; D009052:Leukemia Virus, Murine / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008954:Models, Biological; D012328:RNA Viruses / Q000378:metabolism*; D012190:Retroviridae / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D014779:Virus Replication
D007455:Iodine; D003857:Deoxyuridine