title: Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.
abstract: Murine leukemia virus strains fall into three categories with respect to their ability to propagate in cells of National Institutes of Health (NIH) Swiss and BALB/c mouse embryos. Cultures of NIH cells are 100- to 1,000-fold more sensitive to "N-tropic" strains than BALB/c cell cultures, but are 30- to 100-fold less sensitive to "B-tropic" strains. Some virus strains (dually tropic or "NB-tropic") propagate equally well in both cells. M-MSV pseudotypes show the host-range characteristics of the virus supplying the envelope, both in vitro and in vivo. The host-range characteristics appear to be genetically determined and could not be explained by host-induced modification or virus mixtures. There was no correlation between host range and Gross-AKR or FMR serotype.
mesh_terms: D000818:Animals; D003470:Culture Media; D046508:Culture Techniques; D003911:Dextrans; D004463:Ecology; D004622:Embryo, Mammalian; D005455:Fluorescent Antibody Technique; D005827:Genetics, Microbial; D009052:Leukemia Virus, Murine / Q000254:growth & development / Q000472:pathogenicity*; D051379:Mice; D012703:Serotyping
chemical_list: D003470:Culture Media; D003911:Dextrans