Latent herpes simplex virus in spinal ganglia of mice.
Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis. Infectious virus is replicated when these ganglia are explanted and maintained as organ cultures in vitro.
D000818:Animals; D046508:Culture Techniques; D005727:Ganglia, Spinal / Q000382:microbiology* / Q000473:pathology; D006566:Herpesviridae Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D009500:Neutralization Tests; D018139:Simplexvirus / Q000302:isolation & purification*; D013997:Time Factors; D014779:Virus Replication