Tremorgenic toxin from Penicillium veruculosum.
A new mycotoxin that produces severe tremors and acute toxicity when administered orally or intraperitoneally (ip) to mice and 1-day-old cockerels was obtained from a strain of Penicillium verruculosum Peyronel isolated from peanuts. The ip 50% lethal dose (LD(50)) of this tremorgen was 2.4 mg/kg in mice and 15.2 mg/kg in chickens. Orally administered LD(50) values for the toxin were 126.7 mg/kg in mice and 365.5 mg/kg in chickens. The trivial name "verruculogen" is proposed for this tremorgenic mycotoxin. Physical and chemical characteristics of the mycotoxin are described.
D000284:Administration, Oral; D000818:Animals; D010367:Arachis; D002645:Chickens; D002845:Chromatography; D005260:Female; D005516:Food Microbiology; D005782:Gels; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D009183:Mycotoxins / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000633:toxicity; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism*; D012822:Silicon Dioxide; D013055:Spectrophotometry, Infrared; D014202:Tremor / Q000139:chemically induced*
D005782:Gels; D009183:Mycotoxins; D012822:Silicon Dioxide