Inhibition of chemical carcinogenesis by viral vaccines.
The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C RNA viral vaccine. Rauscher leukemia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary.
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral; D002273:Carcinogens; D003168:Complement Fixation Tests; D005260:Female; D007114:Immunization; D009052:Leukemia Virus, Murine; D008748:Methylcholanthrene; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D011925:Rauscher Virus; D012190:Retroviridae; D012509:Sarcoma / Q000517:prevention & control; D013154:Spleen / Q000276:immunology; D014765:Viral Vaccines / Q000627:therapeutic use*
D000956:Antigens, Viral; D002273:Carcinogens; D014765:Viral Vaccines; D008748:Methylcholanthrene