Virucidal activity of chlorhexidine on strains of Herpesvirus hominis, poliovirus, and adenovirus.
The infectivity titre of two strains of Herpesvirus hominis was reduced by not more than six log(10) units by 90 minutes' exposure to chlorhexidine at a final concentration of 0.02% at room temperature. Under identical conditions the compound was ineffective against a vaccine strain of poliovirus and against an adenovirus. Experimental conditions are described whereby the toxic effect of the disinfectant on the tissue culture assay systems are minimized.
D000256:Adenoviridae / Q000187:drug effects*; D000818:Animals; D000998:Antiviral Agents; D001645:Biguanides / Q000494:pharmacology*; D002277:Carcinoma; D002460:Cell Line; D002642:Chick Embryo; D046508:Culture Techniques; D004202:Disinfectants / Q000494:pharmacology; D006801:Humans; D007822:Laryngeal Neoplasms; D017955:Poliovirus / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*; D013501:Surface-Active Agents / Q000494:pharmacology
D000998:Antiviral Agents; D001645:Biguanides; D004202:Disinfectants; D013501:Surface-Active Agents