Inhibition by  -amanitin of simian virus 40-specific ribonucleic acid synthesis in nuclei of infected monkey cells.
Conditions affecting the synthesis of simian virus 40-specific ribonucleic acid (RNA) in nuclei isolated from lytically infected cells were investigated. Deoxyribonucleic acid-RNA hybridization results show that an alpha-amanitin-sensitive RNA polymerase activity is responsible for transcription of simian virus 40 deoxyribonucleic acid.
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D002478:Cells, Cultured; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D000882:Haplorhini; D007668:Kidney; D009183:Mycotoxins / Q000494:pharmacology*; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D013539:Simian virus 40 / Q000378:metabolism*; D014158:Transcription, Genetic; D014316:Tritium; D014500:Uracil Nucleotides / Q000378:metabolism
D004279:DNA, Viral; D009183:Mycotoxins; D010455:Peptides; D012367:RNA, Viral; D014500:Uracil Nucleotides; D014316:Tritium; D012313:RNA; D012321:DNA-Directed RNA Polymerases