title: Acetylcholine: possible neuromuscular transmitter in Crustacea.
abstract: The tonic flexor muscles of the crayfish abdomen respond with a large depolarizing potential to acetylcholine iontophoresed onto a neuromuscular Junction, but not to glutamate. Excitatory junctional potentials are abolished by d-tubocurarine and enhanced by a cholinesterase inhibitor. The membrane is depolarized and the junctional potentials are desensitized by excess acetylcholine. Thus acetylcholine is thought to be the neuromuscular transmitter.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology / Q000502:physiology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003400:Astacoidea / Q000502:physiology*; D003472:Curare / Q000494:pharmacology; D004491:Edrophonium / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects; D009435:Synaptic Transmission
chemical_list: D004491:Edrophonium; D003472:Curare; D000109:Acetylcholine