The inhibition of plant and animal adenosine 3':5'-cyclic monophosphate phosphodiesterases by a cell-division-promoting substance from tissues of higher plant species.
One member of a new class of cell-division-promoting factors, that has been given the trivial name of cytokinesin I, is a potent inhibitor of adenosine 3':5'-cyclic monophosphate phosphodiesterases of both plant and animal origin. Since an adenylate cyclase has been demonstrated in this study to be present in plant cells, the results suggest that cytokinesin I may be exerting its biological effects in promoting division in cells of higher plant species as a regulator of adenosine 3':5'-cyclic monophosphate.
D000262:Adenylyl Cyclases / Q000302:isolation & purification / Q000378:metabolism; D001921:Brain / Q000201:enzymology; D002247:Carbon Isotopes; D002455:Cell Division / Q000187:drug effects*; D002850:Chromatography, Gel; D000242:Cyclic AMP; D005947:Glucose / Q000494:pharmacology; D006868:Hydrolysis; D007525:Isoelectric Focusing; D009705:Nucleosides / Q000494:pharmacology*; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000378:metabolism; D010941:Plant Tumors / Q000201:enzymology* / Q000378:metabolism; D010947:Plants, Toxic; D011688:Purinones / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D014026:Nicotiana / Q000187:drug effects
D002247:Carbon Isotopes; D009705:Nucleosides; D011688:Purinones; D013806:Theophylline; D000242:Cyclic AMP; D010744:Phosphoric Monoester Hydrolases; D000262:Adenylyl Cyclases; D005947:Glucose