Junctions between cancer cells in culture: ultrastructure and permeability.
Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions.
D001692:Biological Transport; D006528:Carcinoma, Hepatocellular; D002449:Cell Aggregation; D002463:Cell Membrane Permeability; D002478:Cells, Cultured / Q000166:cytology / Q000502:physiology; D004594:Electrophysiology; D005456:Fluorescent Dyes; D006801:Humans; D008113:Liver Neoplasms; D008854:Microscopy, Electron; D009374:Neoplasms, Experimental
D005456:Fluorescent Dyes