Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures.
Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3', 5'-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo.
D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002449:Cell Aggregation; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000032:analysis*; D004622:Embryo, Mammalian; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology*
D000242:Cyclic AMP; D007545:Isoproterenol; D009638:Norepinephrine