Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection.
Infection of Raji cells with Epstein-Barr virus (EBV) causes suppression of cellular deoxyribonucleic acid (DNA) synthesis and fragmentation of the cellular DNA. About 1,000 copies of EBV DNA of normal size (about 5 x 10(7) daltons in a single strand, as shown in an alkaline gradient) are synthesized per cell.
D002051:Burkitt Lymphoma; D002247:Carbon Isotopes; D002460:Cell Line / Q000378:metabolism; D002499:Centrifugation, Density Gradient; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000378:metabolism*; D004279:DNA, Viral / Q000096:biosynthesis*; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000378:metabolism*; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D009693:Nucleic Acid Hybridization; D013395:Sucrose; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D002247:Carbon Isotopes; D004273:DNA, Neoplasm; D004279:DNA, Viral; D014316:Tritium; D013395:Sucrose; D013936:Thymidine