Effect of  -propiolactone on Sendai virus.
The biological properties (infectivity, hemagglutination, hemolysis, cell fusion, neuraminidase) of Sendai virus were dissociated on the basis of sensitivity to beta-propiolactone, by freeze-thawing, by heating at different temperatures, and by adsorption-elution with formalinized chicken erythrocytes. Possible mechanisms whereby beta-propiolactone selectively destroys viral infectivity are discussed.
D000477:Alkylating Agents / Q000494:pharmacology*; D000650:Amnion; D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D002642:Chick Embryo; D002645:Chickens; D003588:Cytopathogenic Effect, Viral; D004912:Erythrocytes / Q000276:immunology; D005347:Fibroblasts; D005557:Formaldehyde; D005615:Freezing; D006168:Guinea Pigs; D006382:Hemadsorption; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000378:metabolism; D006461:Hemolysis; D006571:Heterocyclic Compounds / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D009439:Neuraminidase / Q000378:metabolism; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology / Q000472:pathogenicity; D011422:Propionates / Q000494:pharmacology; D013053:Spectrophotometry
D000477:Alkylating Agents; D006389:Hemagglutinins, Viral; D006571:Heterocyclic Compounds; D007783:Lactones; D011422:Propionates; D005557:Formaldehyde; D009439:Neuraminidase