Effect of blood on the response of the rabbit ear artery to noradrenaline and angiotensin II.
Blood or plasma added to the perfusing Krebs solution potentiated the vasoconstrictor effects of noradrenaline and angiotensin II on the isolated ear artery of the rabbit. The relatively greater increase in the vasoconstrictor effect of angiotensin II in the presence of blood or plasma may account for part of its potent pressor activity in vivo.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000187:drug effects*; D001769:Blood; D003250:Constriction; D004431:Ear, External / Q000098:blood supply; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology*; D010477:Perfusion; D011817:Rabbits
D000804:Angiotensin II; D009638:Norepinephrine