Tilorone hydrochloride: an orally active antiviral agent.
Tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both RNA and DNA groups. The compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection.
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004660:Encephalitis / Q000188:drug therapy*; D004686:Encephalomyocarditis virus / Q000187:drug effects; D005449:Fluorenes / Q000627:therapeutic use*; D006561:Herpes Simplex / Q000188:drug therapy*; D051379:Mice; D009205:Myocarditis / Q000188:drug therapy*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D012672:Semliki forest virus / Q000187:drug effects; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014777:Virus Diseases / Q000188:drug therapy*
D000998:Antiviral Agents; D005449:Fluorenes