Interaction of diazepam with the muscle-relaxant drugs.
Diazepam has been found to increase the duration of the neuromuscular block produced by gallamine and to reduce that produced by succinylcholine. Preliminary studies suggest that the action is at the presynaptic site.
D000768:Anesthesia, General; D003975:Diazepam / Q000494:pharmacology*; D004357:Drug Synergism; D005703:Gallamine Triethiodide / Q000494:pharmacology*; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects; D013390:Succinylcholine / Q000037:antagonists & inhibitors*; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D009467:Neuromuscular Depolarizing Agents; D013390:Succinylcholine; D005703:Gallamine Triethiodide; D003975:Diazepam