[3H]adenosine triphosphate: release during stimulation of enteric nerves.
The isolated taenia coli of the guinea pig takes up tritiated adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, in preference to tritiated inosine and adenine. After uptake, [(3)H]adenosine is converted and retained primarily as [(3)H]adenosine triphosphate. Tritium is released from taenia coli treated with [(3)H]adenosine upon activation of the nonadrenergic inhibitory nerves. These results are consistent with the previous evidence that adenosine triphosphate may be the transmitter from the nerves.
D000227:Adenine Nucleotides / Q000032:analysis* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D003106:Colon / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D004558:Electric Stimulation; D006168:Guinea Pigs; D009197:Myenteric Plexus / Q000502:physiology*; D009705:Nucleosides / Q000494:pharmacology; D013997:Time Factors; D014316:Tritium / Q000032:analysis*
D000227:Adenine Nucleotides; D009705:Nucleosides; D014316:Tritium; D000255:Adenosine Triphosphate; D000242:Cyclic AMP