Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes.
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline does not alter the chemical and nucleotide compositions or the u.v.-absorption characteristics of ribosomal particles, however.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D006041:Goats; D066298:In Vitro Techniques; D008635:Mescaline / Q000494:pharmacology*; D009711:Nucleotides / Q000032:analysis; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis; D012260:Ribonucleases / Q000032:analysis / Q000494:pharmacology; D012270:Ribosomes / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology; D013057:Spectrum Analysis; D014357:Trypsin / Q000494:pharmacology; D014466:Ultraviolet Rays
D009711:Nucleotides; D012260:Ribonucleases; D010744:Phosphoric Monoester Hydrolases; D014357:Trypsin; D008635:Mescaline