Increased activity of two enzymes of pyrimidine biosynthesis de novo in erythrocytes from patients with the Lesch-Nyhan syndrome.
D000225:Adenine / Q000627:therapeutic use; D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D002247:Carbon Isotopes; D002262:Carboxy-Lyases / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D011756:Diphosphates; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000201:enzymology*; D006358:Hot Temperature; D006801:Humans; D007223:Infant; D007926:Lesch-Nyhan Syndrome / Q000188:drug therapy / Q000201:enzymology*; D009963:Orotic Acid; D010430:Pentosyltransferases / Q000097:blood*
D002247:Carbon Isotopes; D011756:Diphosphates; D009963:Orotic Acid; D000493:Allopurinol; D010430:Pentosyltransferases; D002262:Carboxy-Lyases; D000225:Adenine