Bile acids: a pH dependent antibacterial system in the gut?
Bile acids are secreted in the bile in the form of conjugates and many species of intestinal bacteria can rapidly deconjugate them. Studies have shown that an unconjugated bile acid may have bactericidal and bacteriostatic effects, which are pH dependent. It is proposed that unconjugated bile acids may be involved in a homoeostatic mechanism, preventing bacterial growth in the small intestine.
D001439:Bacteroides / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D003016:Clostridium perfringens / Q000187:drug effects / Q000378:metabolism; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D007422:Intestines / Q000382:microbiology*
D001647:Bile Acids and Salts; D003470:Culture Media