Prostaglandin E1 and noradrenaline at the neuromuscular junction.
The effects of prostaglandin E(1) (PGE(1)) on neuromuscular transmission in the frog nerve-sartorius muscle preparation were studied with intracellular recording techniques. PGE(1) was inactive in all concentrations examined; both spontaneous miniature end-plate potentials and evoked end-plate potentials were unchanged after preparations were bathed in up to 2.2x10(-5)M (8 mug/ml) PGE(1). PGE(1) did not prevent the increase in end-plate potential amplitude which frequently occurred on addition of noradrenaline to the bathing solution.
D000818:Animals; D001001:Anura; D002118:Calcium / Q000494:pharmacology; D004594:Electrophysiology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009210:Myofibrils; D009469:Neuromuscular Junction / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects
D011453:Prostaglandins; D008274:Magnesium; D002118:Calcium; D009638:Norepinephrine