Strontium induced rickets: metabolic basis.
Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D(3)-repleted chicks. 1,25-Dihydroxycholecalciferol restores calcium absorption to normal, while 25-hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25-dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine.
D000818:Animals; D001345:Autoradiography; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism*; D007015:Hypophosphatemia, Familial / Q000139:chemically induced*; D007408:Intestinal Absorption / Q000187:drug effects; D012279:Rickets / Q000139:chemically induced; D013324:Strontium / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D014316:Tritium
D014316:Tritium; D002762:Cholecalciferol; D002118:Calcium; D013324:Strontium