Pregnancies after chemotherapy of trophoblastic neoplasms.
We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present.
D000022:Abortion, Spontaneous; D000037:Abruptio Placentae; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001391:Azo Compounds / Q000627:therapeutic use; D004247:DNA / Q000096:biosynthesis; D003609:Dactinomycin / Q000627:therapeutic use; D003638:Deafness / Q000235:genetics; D004485:Eczema / Q000151:congenital; D004487:Edema; D005260:Female; D005313:Fetal Death; D005500:Follow-Up Studies; D006042:Goiter / Q000235:genetics; D006391:Hemangioma / Q000151:congenital; D006801:Humans; D006939:Hyperemesis Gravidarum; D007455:Iodine / Q000378:metabolism; D008466:Mechlorethamine / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009154:Mutation; D010921:Placenta Accreta; D006473:Postpartum Hemorrhage; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D013285:Strabismus / Q000151:congenital; D013771:Tetralogy of Fallot; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014747:Vinblastine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D001391:Azo Compounds; D003609:Dactinomycin; D008466:Mechlorethamine; D014747:Vinblastine; D004247:DNA; D007455:Iodine; D008727:Methotrexate