title: Metabolic differences between normal and neoplastic cells: effects of aminonucleoside on cytoplasmic messenger RNA.
abstract: Treatment of cultured normal human fibroblasts with an adenosine analog (aminonucleoside of puromycin) rapidly inhibits the appearance of cytoplasmic messenger RNA, identified by its polyadenylate sequence. Similar treatment of SV40-transformed fibroblasts does not lead to such an inhibition. Cordycepin. another analog of adenosine. inlhibits polyadenylate-containing cytoplasmic RNA in both types of cell.
mesh_terms: D000227:Adenine Nucleotides / Q000032:analysis; D000606:Amino Sugars / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D003839:Deoxyadenosines / Q000494:pharmacology*; D003864:Depression, Chemical; D005347:Fibroblasts; D006801:Humans; D008168:Lung; D011119:Polynucleotides / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D013539:Simian virus 40; D014316:Tritium; D014529:Uridine / Q000378:metabolism
chemical_list: D000227:Adenine Nucleotides; D000606:Amino Sugars; D000903:Antibiotics, Antineoplastic; D003839:Deoxyadenosines; D011119:Polynucleotides; D012333:RNA, Messenger; D014316:Tritium; D014529:Uridine