Manganese inhibits adenylate cyclase activity and stimulates phosphodiesterase activity in neuroblastoma cells: its possible implication in manganese-poisoning.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D000242:Cyclic AMP; D007093:Imidazoles / Q000494:pharmacology; D007659:Ketones / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology*; D051379:Mice; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*
D007093:Imidazoles; D007659:Ketones; D008345:Manganese; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases