title: Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.
abstract: Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000956:Antigens, Viral / Q000302:isolation & purification*; D003429:Cross Reactions; D005243:Feces / Q000382:microbiology; D006506:Hepatitis A / Q000276:immunology / Q000382:microbiology*; D006511:Hepatitis B Antigens / Q000276:immunology; D006507:Hepatovirus / Q000302:isolation & purification*; D006801:Humans; D008854:Microscopy, Electron; D011863:Radioimmunoassay
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D006511:Hepatitis B Antigens