title: Cross-pathway regulation: histidine-mediated control of histidine, tryptophan, and arginine biosynthetic enzymes in Neurospora crassa.
abstract: In Neurospora crassa, histidine starvation of histidine mutants resulted in derepression of histidine, tryptophan, and arginine biosynthetic enzymes. The same tripartite derepression occurred in wild-type strain 74A when it was grown in medium supplemented with 3-amino-1,2,4-triazole, an inhibitor of histidine biosynthesis. Histidine-mediated derepression of tryptophan and arginine biosynthetic enzymes was not due to a lowered intracellular concentration of tryptophan or arginine, respectively. A discussion of possible mechanisms and of similar studies in prokaryotic and eukaryotic organisms is presented.
mesh_terms: D000640:Amitrole; D001120:Arginine / Q000378:metabolism; D001221:Aspartate Carbamoyltransferase / Q000096:biosynthesis; D002474:Cell-Free System; D004794:Enzyme Repression; D006639:Histidine / Q000378:metabolism*; D007521:Isocitrate Dehydrogenase / Q000096:biosynthesis*; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology / Q000378:metabolism; D009954:Ornithine Carbamoyltransferase / Q000096:biosynthesis; D010744:Phosphoric Monoester Hydrolases / Q000096:biosynthesis*; D010770:Phosphotransferases / Q000096:biosynthesis; D000637:Transaminases / Q000096:biosynthesis; D014166:Transferases / Q000096:biosynthesis*; D014364:Tryptophan / Q000378:metabolism; D014367:Tryptophan Synthase / Q000096:biosynthesis*
chemical_list: D006639:Histidine; D014364:Tryptophan; D001120:Arginine; D007521:Isocitrate Dehydrogenase; D014166:Transferases; D001221:Aspartate Carbamoyltransferase; D009954:Ornithine Carbamoyltransferase; D000637:Transaminases; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases; D014367:Tryptophan Synthase; D000640:Amitrole