Influence of complement on the neutralization of murine cytomegalovirus by rabbit antibody.
Antiserum against murine cytomegalovirus produced in the rabbit contained complement (C')-requiring neutralizing (CRN) antibody. The proportion of CRN was extremely high (up to 98%) during the early portion of an immunization procedure, whereas the antisera produced late had a much lower proportion that required C'. The antiserum produced was specific for MCMV with or without C'.
D000818:Animals; D000914:Antibodies, Viral; D000917:Antibody Formation; D003165:Complement System Proteins; D046508:Culture Techniques; D003587:Cytomegalovirus / Q000276:immunology*; D005347:Fibroblasts; D006801:Humans; D007106:Immune Sera; D007114:Immunization; D051379:Mice; D009500:Neutralization Tests; D014066:Palatine Tonsil; D011817:Rabbits / Q000276:immunology; D013997:Time Factors; D014776:Virus Cultivation
D000914:Antibodies, Viral; D007106:Immune Sera; D003165:Complement System Proteins