Complement-fixing antigens produced by varicella-zoster virus in tissue culture.
The complement-fixing antigens present in tissue cultures infected with varicella-zoster virus were separated into four components. There were (i) a cell-free soluble antigen, (ii) a cell-associated soluble antigen, (iii) a cell membrane-associated antigen, and (iv) a virion antigen. All four antigens were reactive with sera from patients with varicella or zoster, and about 90% of the total complement-fixing activity was found to be nonvirion associated.
D000914:Antibodies, Viral / Q000032:analysis; D000941:Antigens / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D002462:Cell Membrane / Q000276:immunology; D002499:Centrifugation, Density Gradient; D002644:Chickenpox / Q000097:blood; D003168:Complement Fixation Tests; D046508:Culture Techniques; D005347:Fibroblasts; D006562:Herpes Zoster / Q000097:blood; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007106:Immune Sera; D008854:Microscopy, Electron; D011485:Protein Binding; D012995:Solubility
D000914:Antibodies, Viral; D000941:Antigens; D000956:Antigens, Viral; D007106:Immune Sera