title: Formation and biologic role of polyoma virus-antibody complexes. A critical role for complement.
abstract: Interaction of polyoma virus, specific antibody, and complement has been studied. Firm evidence has been gathered that C1 through C3 and not C5 through C9 enhance neutralization of virus-antiviral antibody (V-Ab) complexes. C enhancement of neutralization occurs primarily by agglutination of V-Ab complexes and not by virion lysis or attachment of large protein molecules to the V-Ab complex. In this model, binding of C1, 4, 2, 3 to the V-Ab complex may explain why some viruses concentrate in or infect certain cells bearing C3 receptors such as B lymphocytes, macrophages, and monocytes.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification; D000914:Antibodies, Viral / Q000096:biosynthesis*; D000936:Antigen-Antibody Complex; D001666:Binding Sites, Antibody; D002250:Carbon Radioisotopes; D002417:Cattle; D002499:Centrifugation, Density Gradient; D002848:Chromatography, DEAE-Cellulose; D003165:Complement System Proteins; D006224:Cricetinae; D006168:Guinea Pigs; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D051379:Mice; D008854:Microscopy, Electron; D009500:Neutralization Tests; D011120:Polyomavirus / Q000276:immunology* / Q000302:isolation & purification; D011817:Rabbits; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014461:Ultracentrifugation
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D002250:Carbon Radioisotopes; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D014316:Tritium; D003165:Complement System Proteins; D013936:Thymidine