Rapid changes in nucleoside transport induced by growth inhibitors. Studies with neoplastic mast cells.
Aqueous extracts of murine embryonic or uterine tissue, or [(6)N]O(2)'-dibutyryl 3',5'-adenosine monophosphate (dbc-AMP) which were cytostatic for the murine mastocytoma P815Y in vitro also induced rapid changes in the incorporation of exogenous nucleosides into acid-insoluble material. However, these alterations were not a consequence of growth arrest. Different dose-response curves were obtained for cytostasis and inhibition of [(3)H]-nucleoside incorporation, and changes in [(3)H]thymidine uptake were detected within 15 min of treatment with the inhibitors. Also, there were differential effects of each inhibitor on the incorporation of (3)H-labeled thymidine, uridine, adenosine, or choline into acid-insoluble material.
D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology*; D002452:Cell Count; D002460:Cell Line; D002794:Choline / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D005260:Female; D012515:Mast-Cell Sarcoma / Q000378:metabolism*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism*; D011247:Pregnancy; D013936:Thymidine / Q000378:metabolism; D014020:Tissue Extracts / Q000494:pharmacology*; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014599:Uterus
D009705:Nucleosides; D014020:Tissue Extracts; D014316:Tritium; D003994:Bucladesine; D000241:Adenosine; D002794:Choline; D013936:Thymidine; D014529:Uridine