title: A mutant transcription factor that is activated by 3':5'-cyclic guanosine monophosphate.
abstract: We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli. Genetic data have indicated that the suppressor of the P(-) mutation maps in the structural gene for the transcription factor catabolite activator protein. Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3':5'-cyclic GMP in addition to their normal effector, 3':5'-cyclic AMP.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000378:metabolism; D002874:Chromosome Mapping; D003090:Coliphages; D006152:Cyclic GMP / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism; D005696:Galactosidases / Q000096:biosynthesis; D005796:Genes; D005815:Genetic Code; D007785:Lactose / Q000378:metabolism; D009154:Mutation; D009876:Operon; D014158:Transcription, Genetic / Q000187:drug effects*; D014161:Transduction, Genetic
chemical_list: D001426:Bacterial Proteins; D005696:Galactosidases; D006152:Cyclic GMP; D007785:Lactose