Cyclic guanosine monophosphate: elevation in degenerating photoreceptor cells of the C3H mouse retina.
As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine 3',5'-monophosphate accumulates in retinal photoreceptor cells before they begin to degenerate. It is suggested that degeneration of the photoreceptor cells is related to an imbalance in their metabolism or function which is caused by the elevated levels of cyclic guanosine monophosphate.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism; D002852:Chromatography, Ion Exchange; D002869:Chromosome Aberrations / Q000378:metabolism; D025063:Chromosome Disorders; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D051379:Mice; D008809:Mice, Inbred C3H / Q000254:growth & development / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000378:metabolism; D009410:Nerve Degeneration; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010786:Photoreceptor Cells / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D011485:Protein Binding; D012160:Retina / Q000002:abnormalities / Q000201:enzymology / Q000254:growth & development / Q000294:innervation / Q000378:metabolism*; D013997:Time Factors
D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006152:Cyclic GMP