Rapid viral induction of plasmacytomas in pristane-primed BALB-c mice.
Strain BALB/c mice were injected intraperitoneally with 0.5 milliliter of pristane, and 39 to 56 days later they were infected with Abelson murine leukemia virus, which is a lymphosarcomagenic variant of Moloney virus. Fifty-eight percent of the mice developed lymphosarcoma, and 28 percent developed immunoglobulin-producing plasmacytomas within 20 to 93 days (77 to 149 days after the pristane injection). Two of 57 control mice developed plasmacytomas at days 138 and 166 after a single injection of pristane; no plasmacytomas were found in mice treated with virus alone.
D000473:Alkanes; D000818:Animals; D002273:Carcinogens; D004592:Electrophoresis, Starch Gel; D007070:Immunoglobulin A / Q000302:isolation & purification; D007128:Immunoglobulin Fragments / Q000302:isolation & purification; D007136:Immunoglobulins / Q000302:isolation & purification; D009052:Leukemia Virus, Murine; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000302:isolation & purification; D010954:Plasmacytoma / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D013997:Time Factors
D000473:Alkanes; D002273:Carcinogens; D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007136:Immunoglobulins; D009194:Myeloma Proteins