The carcinogenic effects of dimethylnitrosamine and nitrosomethylurea in European hamsters (Cricetus cricetus L.).
The carcinogenic effects of dimethylnitrosamine (DMN) and nitrosomethylurea (NMU) injected subcutaneously at 3 different dose levels in European hamsters were studied. DMN induced malignant haemangioendotheliomata of the liver and kidney, hepatocellular carcinomata and, in one animal, a cholangiocellular carcinoma. The effect of NMU was localized at the site of administration and resulted in subcutaneous fibrosarcomata, carcinosarcomata or epidermal carcinomata.
D002759:Adenoma, Bile Duct / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced; D002296:Carcinosarcoma / Q000139:chemically induced; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced; D006390:Hemangioendothelioma / Q000139:chemically induced; D007279:Injections, Subcutaneous; D007680:Kidney Neoplasms / Q000139:chemically induced; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000008:administration & dosage / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009602:Nitrosamines; D009607:Nitrosourea Compounds