Immunologic manipulation of metastases due to herpesvirus transformed cells.
Herpes simplex virus type 1 (HSV-1), type 2 (HSV-2), and simian virus 40 (SV40) fail to induce immunity in weanling Syrian hamsters to transplant of hamster cells transformed by HSV-2. However, the development of metastatic tumors is markedly enhanced by prior immunization with HSV-1. Immunization with SV40, ultraviolet-irradiated tumor cells, or ultraviolet-irradiated normal hamster embryo cells inhibits the development of metastases. The HSV-hamster system appears a good one for the study of development, prevention, and control of metastases by mammalian cells transformed by a common human virus.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D006224:Cricetinae; D004622:Embryo, Mammalian; D008175:Lung Neoplasms / Q000276:immunology*; D009362:Neoplasm Metastasis / Q000276:immunology*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D011830:Radiation Effects; D013539:Simian virus 40 / Q000276:immunology / Q000528:radiation effects; D018139:Simplexvirus / Q000276:immunology / Q000528:radiation effects; D014184:Transplantation, Homologous; D014466:Ultraviolet Rays; D014611:Vaccination