title: Production of mucopolysaccharides by normal and transformed cells.
abstract: The rate of hyaluronic acid and sulfated mucopolysaccharide production was measured for hamster embryo fibroblasts and for general oncogenic lines derived by virus transformation. A striking increase in both the rate of hyaluronic acid synthesis and the amount of cell-associated polymer was observed after transformation by herpes simplex type-2 or SV40 virus. Although no corresponding change was observed for the sulfated polysaccharides, the proportion of heparan sulfate increased significantly after transformation.
mesh_terms: D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured / Q000378:metabolism; D002807:Chondroitin / Q000096:biosynthesis; D006224:Cricetinae; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism*; D005944:Glucosamine / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis* / Q000378:metabolism; D000882:Haplorhini; D006493:Heparin / Q000096:biosynthesis; D006497:Heparan Sulfate / Q000096:biosynthesis; D006596:Hexosaminidases / Q000378:metabolism; D006820:Hyaluronic Acid / Q000096:biosynthesis; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007668:Kidney; D007700:Kinetics; D013539:Simian virus 40; D018139:Simplexvirus; D014316:Tritium
chemical_list: D002807:Chondroitin; D005944:Glucosamine; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D006596:Hexosaminidases; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase; D014316:Tritium