title: Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.
abstract: Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.
mesh_terms: D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007478:Iontophoresis; D008839:Microelectrodes; D009991:Oscillometry; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000613:Aminobutyrates; D010852:Picrotoxin