Oestrogen metabolism in cultured human breast tumours.
The interconversion of tritium labelled oestrone and oestradiol-17β has been investigated in human breast tumours maintained in organ culture for 3 days. Benign tumours were significantly different from scirrhous carcinomata both in the concentration of radioactivity taken up by the tissue and in the ratios of oestradiol-17β/oestrone achieved. The fact that malignant tumours were able to convert oestrone to oestradiol-17β is of interest in view of the relatively high plasma levels of oestrone in post-menopausal women.
D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism; D000232:Adenofibroma / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism; D004958:Estradiol / Q000096:biosynthesis / Q000378:metabolism*; D004970:Estrone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008593:Menopause; D009924:Organ Culture Techniques; D014316:Tritium
D014316:Tritium; D004970:Estrone; D004958:Estradiol