Inhibition of acetoacetate decarboxylase by ketophosphonates. Structural and dynamic probes of the active site.
D000090:Acetoacetates; D000096:Acetone / Q000494:pharmacology; D001665:Binding Sites; D001667:Binding, Competitive; D001894:Borohydrides / Q000494:pharmacology; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002384:Catalysis; D003013:Clostridium / Q000201:enzymology; D003903:Deuterium; D004357:Drug Synergism; D006856:Hydrogen Cyanide / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009570:Nitriles / Q000494:pharmacology; D063065:Organophosphonates / Q000494:pharmacology*; D010756:Phosphoric Acids / Q000494:pharmacology; D011522:Protons; D012964:Sodium / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000494:pharmacology
D000090:Acetoacetates; D001894:Borohydrides; D009570:Nitriles; D063065:Organophosphonates; D010756:Phosphoric Acids; D011522:Protons; D013451:Sulfonic Acids; D000096:Acetone; D006856:Hydrogen Cyanide; D012964:Sodium; D003903:Deuterium; D002262:Carboxy-Lyases; C023743:acetoacetate decarboxylase