Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM3, ME1, and IPO-B loci.
In man-Chinese hamster somatic cell hybrids the segregation of the loci for 27 human enzyme markers and the species-specific surface antigens, including the HL-A histocompatibility antigens, was studied. The results show a synteny of the human loci for phosphoglucomutase 3, cytoplasmic malic enzyme, tetrameric indophenol oxidase, and HL-A. Furthermore, evidence is presented that the loci for the human species-specific antigens are distributed over several chromosomes.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D002460:Cell Line; D002874:Chromosome Mapping; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D003576:Electron Transport Complex IV / Q000096:biosynthesis*; D005347:Fibroblasts; D005796:Genes; D008040:Genetic Linkage; D006367:HeLa Cells / Q000276:immunology; D006649:Histocompatibility Antigens; D006801:Humans; D006822:Hybrid Cells / Q000201:enzymology*; D007104:Immune Adherence Reaction; D007962:Leukocytes; D008291:Malate Dehydrogenase / Q000096:biosynthesis*; D010733:Phosphoglucomutase / Q000096:biosynthesis*; D012867:Skin; D013045:Species Specificity
D000941:Antigens; D006649:Histocompatibility Antigens; D008291:Malate Dehydrogenase; D003576:Electron Transport Complex IV; D010733:Phosphoglucomutase