Effects of dibutyryl cyclic AMP on restoration of function of damaged sciatic nerve in rats.
In two experiments, the sciatic nerve of rats was either crushed or hemisected, and N(6),O(2)-dibutyryl adenosine 3',5'-monophosphate or saline was injected intramuscularly near the site of the lesion. In both types of nerve damage, the sensorimotor functions of animals treated with N(6),O(2)-dibutyryl adenosine 3',5'-monophosphate returned earlier than did those of saline-treated control animals.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology*; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D012018:Reflex / Q000187:drug effects; D012584:Sciatic Nerve / Q000502:physiology; D013997:Time Factors
D003994:Bucladesine