Picrotoxin antagonism of gamma-aminobutyric acid inhibitory responses and synaptic inhibition in the rat substantia nigra.
Neurones in the substantia nigra of the rat, anaesthetized with urethane, are inhibited both by electrical stimulation of the ipsilateral caudate nucleus and by iontophoretically applied gamma-aminobutyric acid (GABA). Iontophoretically applied picrotoxin reversibly blocks both of these inhibitory responses. These results are consistent with the hypothesis that GABA is the transmitter released by the inhibitory striato-nigral pathway.
D000613:Aminobutyrates / Q000037:antagonists & inhibitors*; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007478:Iontophoresis; D008839:Microelectrodes; D009991:Oscillometry; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects
D000613:Aminobutyrates; D010852:Picrotoxin