Hyaluronate inhibition of chondrogenesis: antagonism of thyroxine, growth hormone, and calcitonin.
The formation of cartilage-like aggregates in high-density stationary cultures of trypsinized chick embryo precartilage cells is blocked by low concentrations of hyaluronate. Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3',5'-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D002116:Calcitonin / Q000494:pharmacology*; D002356:Cartilage / Q000254:growth & development* / Q000378:metabolism; D002449:Cell Aggregation / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003094:Collagen / Q000096:biosynthesis; D000242:Cyclic AMP / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology*
D013006:Growth Hormone; D006820:Hyaluronic Acid; D002116:Calcitonin; D003094:Collagen; D000242:Cyclic AMP; D013974:Thyroxine