Biological activity of a growth factor for ovarian cells.
The biological activity of a protein growth factor is described. This factor was isolated from bovine pituitary tissue, and its activity was tested on cells of rat ovarian origin. Activity was assayed as growth-promoting potential measured by cell counts and is concentrationdependent. Similar growth stimulation was not produced by several cyclic nucleotides tested, neither was there crossreactivity between this growth factor and a chemically similar one produced by rat liver cells.
D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002417:Cattle; D002452:Cell Count; D002455:Cell Division; D002460:Cell Line; D002845:Chromatography; D006152:Cyclic GMP / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000254:growth & development / Q000378:metabolism; D006133:Growth Substances / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000032:analysis; D009374:Neoplasms, Experimental; D010051:Ovarian Neoplasms; D010053:Ovary / Q000254:growth & development*; D010902:Pituitary Gland / Q000032:analysis; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D006133:Growth Substances; D011506:Proteins; D014316:Tritium; D003994:Bucladesine; D004247:DNA; D006152:Cyclic GMP; D013936:Thymidine