Immunity of Epstein-Barr virus in Hodgkin's disease preceded by infectious mononucleosis.
A patient who developed Hodgkin's disease four years after infectious mononucleosis had elevated serum antibody titres to Epstein-Barr virus and delayed hypersensitivity reactions to membrane antigens prepared from fresh autologous spleen, from spleen cells of another Hodgkin's patient, and from cell lines known to carry the Epstein-Barr virus genome. Additional studies in more lymphoma patients will be needed to determine the significance of the reactivity against tumour and virus-associated antigens which has been documented in this patient.
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006689:Hodgkin Disease / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007244:Infectious Mononucleosis / Q000150:complications*; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D012882:Skin Tests; D013154:Spleen / Q000276:immunology / Q000473:pathology
D000956:Antigens, Viral