Macrophage nonimmunologic recognition: target cell factors related to contact inhibition.
Activated mouse macrophages were not cytotoxic to contact-inhibited nontumorigenic 3T3 fibroblasts, but caused marked destruction to non-contact-inhibited, tumorigenic 3T12 and simian virus 40-transformed fibroblasts. Nonimmunologic recognition and destruction of target cells by activated macrophages is independent of altered morphology, abnormal karyotype, and ability for continuous multiplication in vitro-all characteristics of 3T3 fibroblasts. A modification e f the target cell surface that results in a high in vitro saturation density, agglutinability by plant lectins, and tumorigenicity appears to evoke a cytotoxic response by activated macrophages.
D000818:Animals; D001500:BCG Vaccine; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003260:Contact Inhibition; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D004731:Endotoxins; D004926:Escherichia coli; D005347:Fibroblasts; D007668:Kidney; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013539:Simian virus 40; D014122:Toxoplasma / Q000276:immunology
D001500:BCG Vaccine; D004731:Endotoxins