title: Cross-pathway regulation: tryptophan-mediated control of histidine and arginine biosynthetic enzymes in Neurospora crassa.
abstract: In Neurospora crassa, the starvation of tryptophan mutants for tryptophan resulted in the derepression of tryptophan, histidine, and arginine biosynthetic enzymes. This tryptophan-mediated derepression of histidine and arginine biosynthetic enzymes occurred despite the fact that the tryptophan-starved cells had a higher intracellular concentration of histidine and arginine than did nonstarved cells.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000096:biosynthesis*; D000605:Amino Alcohols; D001120:Arginine / Q000378:metabolism; D001221:Aspartate Carbamoyltransferase / Q000096:biosynthesis; D002474:Cell-Free System; D004794:Enzyme Repression; D006639:Histidine / Q000378:metabolism; D009154:Mutation; D009491:Neurospora / Q000201:enzymology*; D009492:Neurospora crassa / Q000201:enzymology / Q000378:metabolism; D009954:Ornithine Carbamoyltransferase / Q000096:biosynthesis; D010744:Phosphoric Monoester Hydrolases / Q000096:biosynthesis*; D010770:Phosphotransferases / Q000096:biosynthesis; D000637:Transaminases / Q000096:biosynthesis; D014166:Transferases / Q000096:biosynthesis*; D014364:Tryptophan / Q000378:metabolism*; D014367:Tryptophan Synthase / Q000096:biosynthesis*
chemical_list: D000605:Amino Alcohols; D006639:Histidine; D014364:Tryptophan; D001120:Arginine; D000429:Alcohol Oxidoreductases; D014166:Transferases; D001221:Aspartate Carbamoyltransferase; D009954:Ornithine Carbamoyltransferase; D000637:Transaminases; D010770:Phosphotransferases; D010744:Phosphoric Monoester Hydrolases; D014367:Tryptophan Synthase