Metabolic differences between normal and neoplastic cells: effects of aminonucleoside on cytoplasmic messenger RNA.
Treatment of cultured normal human fibroblasts with an adenosine analog (aminonucleoside of puromycin) rapidly inhibits the appearance of cytoplasmic messenger RNA, identified by its polyadenylate sequence. Similar treatment of SV40-transformed fibroblasts does not lead to such an inhibition. Cordycepin. another analog of adenosine. inlhibits polyadenylate-containing cytoplasmic RNA in both types of cell.
D000227:Adenine Nucleotides / Q000032:analysis; D000606:Amino Sugars / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D003839:Deoxyadenosines / Q000494:pharmacology*; D003864:Depression, Chemical; D005347:Fibroblasts; D006801:Humans; D008168:Lung; D011119:Polynucleotides / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis*; D013539:Simian virus 40; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D000227:Adenine Nucleotides; D000606:Amino Sugars; D000903:Antibiotics, Antineoplastic; D003839:Deoxyadenosines; D011119:Polynucleotides; D012333:RNA, Messenger; D014316:Tritium; D014529:Uridine