Isolated adrenal cortex cells: hypersensitivity to adrenocorticotropic hormone after hypophysectomy.
Cells from the adrenals of hypophysectomized rats (up to 28 days after operation) require less adrenocorticotropic hormone to induce one-half maximal rate of production of 3',5'-adenosine monophosphate than do cells from the adrenals of intact rats. A corresponding increase in sensitivity is reflected in the steroidogenic response to adrenocorticotropic hormone up to 2 days after hypophysectomy.
D000225:Adenine / Q000378:metabolism; D000311:Adrenal Glands / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002247:Carbon Isotopes; D000242:Cyclic AMP / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D007016:Hypophysectomy; D066298:In Vitro Techniques; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats
D002247:Carbon Isotopes; D000324:Adrenocorticotropic Hormone; D000242:Cyclic AMP; D000225:Adenine