The malignant cell and its membranes.
In this brief review the hypothesis that altered membrane proteins and glycoproteins may be critical mediators of malignant expression is discussed. Examples of alterations of membrane proteins in malignancy are presented. Data is summarized showing changes in the carbohydrate components of glycoproteins of surface and internal membranes of malignant cells in culture as compared to their normal counterparts.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002460:Cell Line; D002462:Cell Membrane / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D002850:Chromatography, Gel; D006224:Cricetinae; D006020:Glycopeptides / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis; D006868:Hydrolysis; D007668:Kidney; D011402:Pronase; D012794:Sialic Acids / Q000032:analysis; D014357:Trypsin
D006020:Glycopeptides; D006023:Glycoproteins; D012794:Sialic Acids; D014357:Trypsin; D011402:Pronase