Murine C-type RNA virus from spontaneous neoplasms: in vitro host range and oncogenic potential.
Strain BALB/c mice harbor at least two host range variants of marine leukemia virus. One variant, which is host-cell tropic, is the predominant isolate from neoplastic tissues and produced lymphoreticular neoplasms when injected into BALB/c newborn mice. A second variant, whicht is isolated throughout life, grows poorly in host embryonic cells in culture and was not associated with lymphoreticular neoplasm induction when injected into newborn BALB/c mice.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002277:Carcinoma / Q000382:microbiology; D002460:Cell Line; D004622:Embryo, Mammalian; D006390:Hemangioendothelioma / Q000382:microbiology; D009052:Leukemia Virus, Murine / Q000276:immunology / Q000302:isolation & purification; D007942:Leukemia, Experimental / Q000209:etiology / Q000382:microbiology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000382:microbiology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000382:microbiology; D008325:Mammary Neoplasms, Experimental / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009208:Myoepithelioma / Q000382:microbiology; D012190:Retroviridae / Q000302:isolation & purification; D012513:Sarcoma, Experimental / Q000382:microbiology; D013154:Spleen / Q000382:microbiology; D014779:Virus Replication
D000956:Antigens, Viral