title: Spin-labeled sulfonyl fluorides as active site probes of protease structure. I. Comparison of the active site environments in alpha-chymotrypsin and trypsin.
mesh_terms: D000578:Amidines / Q000494:pharmacology; D001555:Benzene Derivatives / Q000494:pharmacology; D001557:Benzenesulfonates / Q000378:metabolism* / Q000494:pharmacology; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003497:Cyclic N-Oxides / Q000378:metabolism* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005461:Fluorine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000494:pharmacology; D007536:Isomerism; D008961:Models, Structural; D010880:Piperidines / Q000378:metabolism; D011487:Protein Conformation; D011758:Pyrroles / Q000378:metabolism; D011759:Pyrrolidines / Q000378:metabolism; D013329:Structure-Activity Relationship; D014105:Tosyl Compounds / Q000378:metabolism; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000378:metabolism
chemical_list: D000578:Amidines; D001555:Benzene Derivatives; D001557:Benzenesulfonates; D003497:Cyclic N-Oxides; D007211:Indoles; D010880:Piperidines; D011758:Pyrroles; D011759:Pyrrolidines; D014105:Tosyl Compounds; D014361:Trypsin Inhibitors; D005461:Fluorine; D002918:Chymotrypsin; D014357:Trypsin