Effects of collagen and of aspirin on the concentration of guanosine 3':5'-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique.
A method is described for isolating cyclic [(3)H]GMP from platelets preincubated with [(3)H]guanine. Collagen increased and aspirin decreased the cyclic [(3)H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.
D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003094:Collagen / Q000494:pharmacology*; D006152:Cyclic GMP / Q000097:blood*; D006147:Guanine / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D006147:Guanine; D003094:Collagen; D006152:Cyclic GMP; D001241:Aspirin