title: Restricted replication of vesicular stomatitis virus in human lymphoblastoid cells.
abstract: Replication of vesicular stomatitis virus (VSV) is restricted in one human lymphoblastoid cell line (Raji), but not in another similar cell line (Wil-2), compared with growth in HeLa cells. This restriction is characterized by a low proportion of cells yielding infectious virus and is associated with limited production of 42S virion RNA. Primary transcription of 13S and 26S VSV-specific RNA is not restricted in Raji cells, and the 13S RNA produced contains adenylate-rich sequences. This suggests that the block in Raji cells involves some step required for the replication of virion RNA.
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D002051:Burkitt Lymphoma; D002460:Cell Line; D002478:Cells, Cultured / Q000382:microbiology*; D002499:Centrifugation, Density Gradient; D004591:Electrophoresis, Polyacrylamide Gel; D006367:HeLa Cells; D006801:Humans; D007739:L Cells; D008297:Male; D008441:Maxillary Neoplasms; D051379:Mice; D012367:RNA, Viral / Q000032:analysis / Q000096:biosynthesis; D014158:Transcription, Genetic; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014721:Vesicular stomatitis Indiana virus / Q000032:analysis / Q000254:growth & development* / Q000378:metabolism; D014779:Virus Replication
chemical_list: D012367:RNA, Viral; D014316:Tritium; D000241:Adenosine; D014529:Uridine