Mutagenicity of thioxanthenes (hycanthone, lucanthone and four indazole derivatives) at the TK locus in cultured mammalian cells.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells; D004305:Dose-Response Relationship, Drug; D004330:Drosophila / Q000187:drug effects / Q000378:metabolism; D005787:Gene Frequency; D005796:Genes / Q000187:drug effects*; D006579:Heterozygote; D007945:Leukemia, Lymphoid; D008154:Lucanthone / Q000494:pharmacology*; D008698:Mesylates / Q000494:pharmacology*; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000494:pharmacology*; D013936:Thymidine / Q000494:pharmacology; D013937:Thymidine Kinase / Q000378:metabolism; D013997:Time Factors
D008698:Mesylates; D009153:Mutagens; D013892:Thioxanthenes; D013937:Thymidine Kinase; D008154:Lucanthone; D001973:Bromodeoxyuridine; D013936:Thymidine