Comparative trial of P1496, a new non-steroidal oestrogen analogue.
The results are reported of a preliminary trial of P1496, a new non-steroidal oestrogen analogue, compared with a conjugated equine oestrogen and a placebo. The oestrogenicity of both substances was well substantiated by vaginal epithelial maturation indices. P1496 was superior to conjugated equine oestrogen in producing a significant reduction of plasma calcium levels and a possible reduction in serum cholesterol. Conjugated oestrogen caused slightly more nausea than P1496 but there were no notable side effects from either drug. P1496 is considered to be at least as effective an oestrogenic substance as conjugated oestrogen and worthy of further therapeutic evaluation.
D000469:Alkaline Phosphatase / Q000097:blood; D001794:Blood Pressure; D001835:Body Weight; D002118:Calcium / Q000097:blood; D002369:Castration; D002784:Cholesterol / Q000097:blood; D004414:Dyspareunia / Q000139:chemically induced; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D007044:Hysterectomy; D007455:Iodine / Q000097:blood; D007783:Lactones / Q000494:pharmacology*; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010758:Phosphorus / Q000097:blood; D011485:Protein Binding; D012118:Resorcinols / Q000494:pharmacology*; D014621:Vagina / Q000187:drug effects; D014626:Vaginal Smears
D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D007783:Lactones; D012118:Resorcinols; D010758:Phosphorus; D007455:Iodine; D002784:Cholesterol; D000469:Alkaline Phosphatase; D002118:Calcium