Hypothesis: Inhibition of E prostaglandin-sensitive adenyl cyclase as the mechanism of morphine analgesia.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D000242:Cyclic AMP / Q000096:biosynthesis*; D003864:Depression, Chemical; D005459:Fluorides / Q000494:pharmacology; D006168:Guinea Pigs; D003932:Heroin / Q000494:pharmacology; D066298:In Vitro Techniques; D007981:Levorphanol / Q000494:pharmacology; D008614:Meperidine / Q000494:pharmacology; D008691:Methadone / Q000494:pharmacology; D051379:Mice; D009019:Morphinans / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011955:Receptors, Drug; D012964:Sodium / Q000494:pharmacology; D013268:Stimulation, Chemical
D009019:Morphinans; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011955:Receptors, Drug; D007981:Levorphanol; D009270:Naloxone; D003932:Heroin; D009020:Morphine; D008614:Meperidine; D012964:Sodium; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D005459:Fluorides; D001241:Aspirin; D008691:Methadone