title: Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
mesh_terms: D000012:Abetalipoproteinemia / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D002648:Child; D002784:Cholesterol / Q000096:biosynthesis / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003513:Cycloheximide / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology*; D005977:Glutarates; D006720:Homozygote; D006801:Humans; D006949:Hyperlipidemias / Q000201:enzymology* / Q000235:genetics*; D007231:Infant, Newborn; D007328:Insulin / Q000494:pharmacology; D008075:Lipoproteins, HDL / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000494:pharmacology; D008297:Male; D008798:Mevalonic Acid; D012867:Skin / Q000201:enzymology; D014316:Tritium
chemical_list: D002250:Carbon Radioisotopes; D005977:Glutarates; D007328:Insulin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014316:Tritium; D002784:Cholesterol; D003513:Cycloheximide; D000429:Alcohol Oxidoreductases; D008798:Mevalonic Acid