Activation of the murine sarcoma virus genome after infection with the murine leukemia virus as determined by cell agglutination.
Non-virus-producing NIH/3T3 cells transformed by the murine sarcoma virus are agglutinated by conconavalin A to the same low level as normal NIH/3T3 cells. Infection with the murine leukemia virus greatly increases the agglutination of transformed cells but not that of normal cells. These data suggest that the morphological expression of cell transformation and the surface alterations associated with increased cell agglutination are controlled by the expressions of different sarcoma virus genes.
D000371:Agglutination / Q000187:drug effects; D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D003208:Concanavalin A / Q000494:pharmacology; D005347:Fibroblasts; D017988:Gammaretrovirus; D005838:Genotype; D009052:Leukemia Virus, Murine; D051379:Mice; D008815:Mice, Inbred Strains / Q000196:embryology; D012509:Sarcoma / Q000382:microbiology*
D003208:Concanavalin A