Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D002417:Cattle; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000517:prevention & control; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D003579:Cytochrome Reductases / Q000032:analysis; D003574:Cytochrome c Group; D003640:Dealkylation; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006591:Hexobarbital / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008854:Microscopy, Electron; D008862:Microsomes, Liver / Q000201:enzymology; D009019:Morphinans / Q000378:metabolism; D009243:NAD; D009929:Organ Size; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use*; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012710:Serum Albumin, Bovine; D013997:Time Factors
D003574:Cytochrome c Group; D009019:Morphinans; D011506:Proteins; D009243:NAD; D011285:Pregnenolone Carbonitrile; D012710:Serum Albumin, Bovine; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D003579:Cytochrome Reductases; D010634:Phenobarbital