Effect of a sulphated glycopeptide on rat gastric acid secretion stimulated by histamine, bethanechol, pentagastrin and dibutyryl cyclic AMP.
The antisecretory activity of a semisynthetic sulphated glycopeptide (GLPS) was studied in rats in which the secretion rates of gastric acid were detennined on the perfused stomach preparation. GLPS at 1 mg/kg i.v. reduced the hypersecretory effect of dibutyryl cyclic AMP, histamine, pentagastrin, bethanechol but not of theophylline.
D000818:Animals; D001626:Bethanechol Compounds / Q000037:antagonists & inhibitors; D000242:Cyclic AMP / Q000037:antagonists & inhibitors; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D006020:Glycopeptides / Q000494:pharmacology*; D006633:Histamine Antagonists; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D001626:Bethanechol Compounds; D006020:Glycopeptides; D006633:Histamine Antagonists; D013806:Theophylline; D000242:Cyclic AMP; D010418:Pentagastrin