Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses.
Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1(n) or Fv-1(b) alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D006224:Cricetinae; D005260:Female; D051379:Mice; D008979:Moloney murine leukemia virus / Q000276:immunology; D009500:Neutralization Tests; D010053:Ovary; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development* / Q000276:immunology; D010948:Viral Plaque Assay; D014764:Viral Proteins; D014779:Virus Replication
D000956:Antigens, Viral; D014764:Viral Proteins