A light and electron microscopic study of the liver in case of erythrohepatic protoporphyria and in griseofulvin-induced porphyria in mice.
The light- and electron-microscopic appearances of a liver biopsy from a case of erythrohepatic protoporphyria are compared with the appearances of the liver in griseofulvin-induced porphyria in mice. Crystals are present in hepatocytes and in the bile secretory pathways in each case. The nature and significance of these is discussed.
D000328:Adult; D000818:Animals; D001706:Biopsy; D003593:Cytoplasm / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D004912:Erythrocytes / Q000032:analysis; D005243:Feces / Q000032:analysis; D005260:Female; D006118:Griseofulvin; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure; D007728:Kupffer Cells / Q000648:ultrastructure; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008860:Microscopy, Ultraviolet; D008930:Mitochondria, Liver / Q000648:ultrastructure; D010586:Phagocytes / Q000648:ultrastructure; D011164:Porphyrias / Q000139:chemically induced / Q000473:pathology*; D011166:Porphyrins / Q000302:isolation & purification; D012882:Skin Tests
D011166:Porphyrins; D006118:Griseofulvin