A study of the metabolic requirements for the contractile action of angiotensin upon guinea-pig ileum.
1 Acetylcholine and angiotensin elicit a contraction of guinea-pig ileum. The metabolic requirements for these actions have been investigated.2 The angiotensin-induced response was far more dependent upon the presence of glucose than was the response to acetylcholine.3 Anoxia and oxidative enzyme inhibition preferentially reduced the angiotensin-induced response.4 The significance of these results is discussed. It is concluded that the response to angiotensin is dependent upon an ATP source distinct from that required by the contractile process. It is further shown that this energy-dependent stage cannot be identified with the indirect, cholinergic component of the angiotensin response in this tissue.
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology; D004558:Electric Stimulation; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000378:metabolism; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D000804:Angiotensin II; D008353:Mannitol; D002248:Carbon Monoxide; D006632:Histamine; D000255:Adenosine Triphosphate; D012601:Scopolamine; D005947:Glucose; D009584:Nitrogen; D000109:Acetylcholine; D010100:Oxygen