Hypoglycemia and insular hyperplasia: review of 148 cases.
On the bases of personal experience and the series of 148 cases from an international inquiry and a review of the literature, the relation between insular hyperplasia and hypoglycemia was examined. The fundamental points in this investigation included: age, diagnostic investigations, histological findings and postoperative results. The data on the patients with insular hyperplasia indicates that 83% were of adult age. Insular hyperplasia was the only abnormal factor determined to be present. Through treatment a high percentage of cases (71%) was cured. From a practical surgical point of view, differentiation between occult insulomas and insular hyperplasia is not critical. Consequently, good results can be achieved in botlh diseases by practicing a progressive blind resection guided by examination of the operated specimen and by intra-operative blood sugar levels.
D007516:Adenoma, Islet Cell / Q000150:complications; D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000175:diagnosis; D005215:Fasting; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006965:Hyperplasia; D007003:Hypoglycemia / Q000175:diagnosis / Q000209:etiology*; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000150:complications; D012737:Sex Factors; D014044:Tolbutamide
D001786:Blood Glucose; D014044:Tolbutamide