Preliminary observations pertaining to polyadenylation of rhinovirus RNA.
Human rhinovirus type 14 contained polyadenylated RNA. Virus growth in HeLa cells was inhibited by cordycepin or polyuridilic acid and stimulated by polyadenylic acid. Polyadenylic acid also reversed cordycepin inhibition of virus-induced cytopathology of infected HeLa cells.
D000227:Adenine Nucleotides / Q000032:analysis* / Q000494:pharmacology; D000241:Adenosine; D001203:Ascomycota; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005656:Fungal Proteins / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D008851:Micropore Filters; D011072:Poly U / Q000494:pharmacology; D011119:Polynucleotides / Q000032:analysis* / Q000494:pharmacology; D012367:RNA, Viral / Q000032:analysis*; D012229:Rhinovirus / Q000032:analysis* / Q000254:growth & development; D012260:Ribonucleases; D014316:Tritium; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000227:Adenine Nucleotides; D005656:Fungal Proteins; D011119:Polynucleotides; D012367:RNA, Viral; D014316:Tritium; D011072:Poly U; D012260:Ribonucleases; D000241:Adenosine