title: Infectious bursal disease in New Brunswick.
abstract: A flock of four week old chickens experienced a disease of sudden onset in which the only symptoms were those of depression shortly before death, and in which the predominant histological lesion was necrosis of lymphocytes in the bursa of Fabricius.A virus, designated strain Sk-1, was isolated from pooled bursal tissue of affected birds and was serologically identified as a strain of the infectious bursal agent. This virus was chloroform resistant, did not hemagglutinate guinea pig or chicken erythrocytes and did not produce a cytopathic effect in chick embryo tissue cultures. Equivocal results were obtained in filtration studies but the agent was less than 100nm in diameter. Four week old chicks inoculated with strain Sk-1 developed microscopic lesions in the bursa of Fabricius which were similar to those seen in the original field specimens. Inoculated chick embryos exhibited characteristic macroscopic lesions and necrosis of vascular tissue was a common histological change.A limited serological survey of local poultry flocks indicated that infection by this agent had occurred in four of the ten flocks examined.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000382:microbiology / Q000473:pathology; D002642:Chick Embryo; D002645:Chickens / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D009500:Neutralization Tests; D009509:New Brunswick; D011201:Poultry Diseases / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D012087:Reoviridae / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D012088:Reoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D014776:Virus Cultivation