Acidophilic adenoma of the pituitary with polyneuropathy.
An acromegalic man aged 70 developed progressive polyneuropathy affecting mainly the extremities. The peripheral nerves showed hypertrophic neuropathy and accumulation of acid mucopolysaccharides in the nerve without `onion bulb' formation. The myelin showed a lamellar disintegration and vesicular formation. It is suggested that the association of these findings represents a pathological entity, acromegalic polyneuropathy.
D000172:Acromegaly / Q000209:etiology*; D000239:Adenoma, Acidophil / Q000150:complications*; D000368:Aged; D003711:Demyelinating Diseases; D004558:Electric Stimulation; D005071:Evoked Potentials; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000503:physiopathology; D009186:Myelin Sheath; D010525:Peripheral Nerves / Q000473:pathology / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000150:complications*