Prolactin receptors in estrogen receptor-deficient mammary carcinoma.
We demonstrate for the first time the presence of specific high-affinity receptors for prolactin in rat mammayy carcinoma. There appear to be no significant differences between normal rat mammary tissue and the transplantable, estrogen receptor-deficient R3230AC tumor with regard to the number of binding sites, the affinity of the receptor for prolactin, or the specificity of binding.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D046508:Culture Techniques; D004837:Epinephrine / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007457:Iodine Radioisotopes; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011956:Receptors, Cell Surface; D012756:Sheep
D004967:Estrogens; D007328:Insulin; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D011388:Prolactin; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone; D004837:Epinephrine