Potential antitumor agents. 11. Inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000201:enzymology; D004351:Drug Resistance; D005260:Female; D008113:Liver Neoplasms / Q000201:enzymology; D015122:Mercaptopurine; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D051381:Rats; D012262:Ribonucleoside Diphosphate Reductase / Q000037:antagonists & inhibitors; D012510:Sarcoma 180 / Q000188:drug therapy / Q000201:enzymology; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D013882:Thiosemicarbazones; D015122:Mercaptopurine; D012262:Ribonucleoside Diphosphate Reductase; D000469:Alkaline Phosphatase