Enzyme release from polymorphonuclear leukocyte lysosomes: regulation by autonomic drugs and cyclic nucleotides.
Osmotic release of beta-glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3',5'-monophosphate, and accelerated by cholinergic agents and guanosine 3',5'-monophosphate. These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5'-monophosphate and guanosine 5'-monophosphate do not inodify lysosomal enzyme release.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002794:Choline / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology*; D006152:Cyclic GMP / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism*; D006168:Guinea Pigs; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D014439:Tyramine / Q000494:pharmacology
D010277:Parasympathomimetics; D013566:Sympathomimetics; D010656:Phenylephrine; D000242:Cyclic AMP; D005966:Glucuronidase; D006152:Cyclic GMP; D002794:Choline; D000109:Acetylcholine; D009638:Norepinephrine; D014439:Tyramine