Visna virus infection of American lambs.
Random-bred fetal and 4-week-old American lambs, inoculated intracerebrally with visna virus, developed a persistent infection in the brain and sometimes in the lung. The pathologic changes present in these lambs were similar to the early lesions of visna in Icelandic sheep, thus providing a possible model for the study of virus-induced demyelinating disease.
D000818:Animals; D000831:Animals, Newborn; D001927:Brain Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003588:Cytopathogenic Effect, Viral; D003711:Demyelinating Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005333:Fetus; D007055:Iceland; D009656:North America; D011020:Pneumonia, Pneumocystis / Q000382:microbiology / Q000662:veterinary; D011247:Pregnancy; D012328:RNA Viruses / Q000254:growth & development*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology* / Q000473:pathology; D013045:Species Specificity; D014790:Visna-maedi virus / Q000254:growth & development