title: Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase.
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000494:Allosteric Regulation; D000818:Animals; D003065:Coenzyme A / Q000494:pharmacology; D006150:Guanine Nucleotides / Q000494:pharmacology; D006168:Guinea Pigs; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors / Q000378:metabolism; D007656:Ketoglutaric Acids / Q000378:metabolism*; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000166:cytology; D008297:Male; D008433:Mathematics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D009243:NAD / Q000008:administration & dosage / Q000494:pharmacology; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010728:Phosphoenolpyruvate / Q000494:pharmacology; D051381:Rats; D013386:Succinates / Q000494:pharmacology
chemical_list: D000227:Adenine Nucleotides; D006150:Guanine Nucleotides; D007656:Ketoglutaric Acids; D009097:Multienzyme Complexes; D013386:Succinates; D009243:NAD; D010728:Phosphoenolpyruvate; D007658:Ketone Oxidoreductases; D007655:Ketoglutarate Dehydrogenase Complex; D003065:Coenzyme A