N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture.
D000818:Animals; D001221:Aspartate Carbamoyltransferase / Q000037:antagonists & inhibitors*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D001639:Bicarbonates; D002219:Carbamates; D002250:Carbon Radioisotopes; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002852:Chromatography, Ion Exchange; D005347:Fibroblasts; D000882:Haplorhini; D007668:Kidney; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D063065:Organophosphonates / Q000494:pharmacology*; D009943:Organophosphorus Compounds; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives; D013539:Simian virus 40; D013045:Species Specificity; D013997:Time Factors; D014316:Tritium; D014529:Uridine / Q000494:pharmacology
D001639:Bicarbonates; D002219:Carbamates; D002250:Carbon Radioisotopes; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D014316:Tritium; D001224:Aspartic Acid; C013195:sparfosic acid; D001221:Aspartate Carbamoyltransferase; D010746:Phosphonoacetic Acid; D014529:Uridine