title: Polioviruses, coxsackieviruses, and echoviruses comparison of the genomes by RNA hybridization.
abstract: Hybridization of single-stranded RNA from virions of human enteroviruses with denatured double-stranded RNA from infected cells indicates that a minimum of about 5% of the genome is shared by these viruses. Polynucleotide sequence relationships, furthermore, are consistent with the biologic classification into polioviruses, coxsackieviruses groups A and B, and echoviruses. In general, about 30 to 50% of the nucleotide sequences are shared by different serotypes of virus within each of these major groups, whereas among different groups less than 20% homology is observed. Coxsackievirus B4 appears to be more closely related to echoviruses than to group A coxsackieviruses, whereas polioviruses are only distantly related to any of the other agents.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002848:Chromatography, DEAE-Cellulose; D003429:Cross Reactions; D004121:Dimethyl Sulfoxide; D004770:Enterovirus / Q000032:analysis / Q000145:classification*; D029822:Enterovirus B, Human / Q000032:analysis / Q000145:classification*; D000882:Haplorhini; D007668:Kidney; D008722:Methods; D051379:Mice; D009500:Neutralization Tests; D009693:Nucleic Acid Hybridization; D010759:Phosphorus Isotopes; D017955:Poliovirus / Q000032:analysis / Q000145:classification*; D012367:RNA, Viral / Q000032:analysis / Q000302:isolation & purification; D012703:Serotyping; D014776:Virus Cultivation
chemical_list: D010759:Phosphorus Isotopes; D012367:RNA, Viral; D004121:Dimethyl Sulfoxide