The three-state model: a minimal allosteric description of homotropic and heterotropic effects in the binding of ligands to hemoglobin.
The effect of hydrogen ion, chloride, and 2,3-diphosphoglycerate upon the oxygen binding of hemoglobin may be satisfactorily described by an allosteric model employing three affinity states. The allosteric two-state model does not provide even an approximate description except under defined extreme conditions. In particular, the two-state model cannot provide a correct interpretation of recently reported electron spin resonance and nuclear magnetic resonance data.
D001665:Binding Sites; D002712:Chlorides; D004163:Diphosphoglyceric Acids; D004578:Electron Spin Resonance Spectroscopy; D006454:Hemoglobins; D006859:Hydrogen; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010108:Oxyhemoglobins
D002712:Chlorides; D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D008024:Ligands; D010108:Oxyhemoglobins; D006859:Hydrogen