Vasopressin: possible role of microtubules and microfilaments in its action.
Colchicine, vinblastine, podophyllotoxin, and cytochalasin B inhibit the action of vasopressin and cyclic adenosine monophosphate on osmotic water movement across the toad bladder. The findings suggest that microtubules, and possibly microfilaments, play a role in the action of vasopressin, perhaps through involvement in the mechanism of release of secretory material from the bladder epithelial cells.
D000818:Animals; D001692:Biological Transport; D002024:Bufo marinus; D003078:Colchicine / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D003571:Cytochalasin B / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D008870:Microtubules / Q000502:physiology*; D009940:Organoids / Q000502:physiology*; D009995:Osmosis; D011034:Podophyllotoxin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism; D001743:Urinary Bladder / Q000166:cytology / Q000378:metabolism*; D014667:Vasopressins / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D014747:Vinblastine / Q000494:pharmacology; D014867:Water / Q000378:metabolism*
D014867:Water; D014667:Vasopressins; D003571:Cytochalasin B; D014747:Vinblastine; D012964:Sodium; D000242:Cyclic AMP; D011034:Podophyllotoxin; D003078:Colchicine