Inhibition of macromolecular synthesis in Escherichia coli by protease inhibitors. Specific reversal by glutathione of the effects of chloromethyl ketones.
D000476:Alkanesulfonates / Q000494:pharmacology; D000578:Amidines / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D002713:Chlorine / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005696:Galactosidases / Q000096:biosynthesis; D005978:Glutathione / Q000378:metabolism / Q000494:pharmacology*; D005998:Glycine / Q000494:pharmacology; D007461:Iodoacetates / Q000494:pharmacology; D008239:Lysine / Q000494:pharmacology; D010447:Peptide Hydrolases / Q000378:metabolism; D010647:Phenyl Ethers / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology; D011480:Protease Inhibitors; D012329:RNA, Bacterial / Q000096:biosynthesis; D012260:Ribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000037:antagonists & inhibitors; D014105:Tosyl Compounds / Q000494:pharmacology*
D000476:Alkanesulfonates; D000578:Amidines; D001426:Bacterial Proteins; D002250:Carbon Radioisotopes; D007461:Iodoacetates; D010647:Phenyl Ethers; D011480:Protease Inhibitors; D012329:RNA, Bacterial; D013438:Sulfhydryl Compounds; D014105:Tosyl Compounds; D010649:Phenylalanine; D002713:Chlorine; D012260:Ribonucleases; D005696:Galactosidases; D010447:Peptide Hydrolases; D005978:Glutathione; D008239:Lysine; D005998:Glycine