title: Temperature-sensitive mutations in Drosophila melanogaster. XII. The genetic and developmental effects of dominant lethals on chromosome 3.
abstract: Out of 25,000 EMS-treated third chromosomes examined, ten dominant temperature-sensitive (DTS) lethal mutations which are lethal when heterozygous at 29 degrees C but survive at 22 degrees C were recovered. Seven of the eight mutations mapped were tested for complementation; these mutants probably define eight loci. Only DTS-2 survived in homozygous condition at 22 degrees C; homozygous DTS-2 females expressed a maternal effect on embryonic viability. Two of the mutant-bearing chromosomes, DTS-1 and DTS-6, exhibited dominant phenotypes similar to those associated with Minutes. Each of the seven mutants examined exhibited a characteristic phenotype with respect to the time of death at 29 degrees C and the temperature-sensitive period during development. Only DTS-4 exhibited dominant lethality in triploid females.
mesh_terms: D000476:Alkanesulfonates / Q000494:pharmacology; D000818:Animals; D002875:Chromosomes; D004331:Drosophila melanogaster / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D009154:Mutation; D010641:Phenotype; D013696:Temperature
chemical_list: D000476:Alkanesulfonates