Involvement of the superoxide anion in sulphoxidation.
Sulphoxidation of compounds capable of undergoing biological sulphoxidation has been demonstrated in a model system (NADH-phenazine methosulphate-O(2)), known to generate superoxide anions (O(2) (-)). Addition of superoxide dismutase to this system results in complete inhibition, suggesting the involvement of O(2) (-) in sulphoxidation.
D000818:Animals; D000838:Anions; D002746:Chlorpromazine; D002848:Chromatography, DEAE-Cellulose; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000201:enzymology; D009243:NAD; D010084:Oxidation-Reduction; D010100:Oxygen; D010619:Phenazines / Q000494:pharmacology; D012756:Sheep; D013053:Spectrophotometry; D013454:Sulfoxides; D013482:Superoxide Dismutase / Q000097:blood* / Q000378:metabolism
D000838:Anions; D010619:Phenazines; D013454:Sulfoxides; D009243:NAD; D013482:Superoxide Dismutase; D010100:Oxygen; D002746:Chlorpromazine