Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy.
Inoculation of the cornea, lip, or footpad of mice with herpes simplex virus type 1 resulted in a latent infection of the local sensory ganglia. Inoculation of the vagina and cervix with herpes simplex virus type 2, as well as type 1, also induced a latent ganglionic infection. With the use of sciatic nerve section as a stimulus, a reproducible model of viral reactivation in vivo was established.
D000818:Animals; D003315:Cornea; D003714:Denervation; D005260:Female; D005528:Foot; D005727:Ganglia, Spinal / Q000382:microbiology*; D006561:Herpes Simplex; D008046:Lip; D051379:Mice; D008954:Models, Biological; D009474:Neurons / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000382:microbiology; D012584:Sciatic Nerve; D018139:Simplexvirus / Q000254:growth & development* / Q000302:isolation & purification; D013997:Time Factors; D014276:Trigeminal Nerve / Q000382:microbiology*; D014621:Vagina