title: Regulation of staphylococcal enterotoxin B: effect of anaerobic shock.
abstract: The metabolism of glucose during enterotoxin B synthesis in Staphylococcus aureus S-6 was examined under anaerobic conditions in the presence and absence of nitrate. The repression of enterotoxin synthesis which occurs during the oxidative metabolism of glucose was relieved after a shift to anaerobic conditions; glucose was then converted primarily to lactic acid and was metabolized more rapidly, presumably to obtain the equivalent amount of energy available aerobically. A greater proportion of oxidized end products and evidently more energy per glucose molecule was produced in the presence of oxygen. Thus, available energy as judged by a change in the type and proportion of end products appears to be related to the degree of toxin repression. As expected, the addition of nitrate during anaerobic glucose metabolism prevented derepression of toxin synthesis.
mesh_terms: D000085:Acetates / Q000096:biosynthesis; D000332:Aerobiosis; D000693:Anaerobiosis; D001426:Bacterial Proteins / Q000096:biosynthesis; D002074:Butanones / Q000096:biosynthesis; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002845:Chromatography; D003470:Culture Media; D003653:Decarboxylation; D004579:Electron Transport; D004768:Enterotoxins / Q000096:biosynthesis*; D000431:Ethanol / Q000096:biosynthesis; D005561:Formates / Q000096:biosynthesis; D005782:Gels; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D007930:Leucine / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism; D011773:Pyruvates / Q000096:biosynthesis / Q000378:metabolism; D012822:Silicon Dioxide; D013210:Staphylococcus / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000085:Acetates; D001426:Bacterial Proteins; D002074:Butanones; D002247:Carbon Isotopes; D003470:Culture Media; D004768:Enterotoxins; D005561:Formates; D005782:Gels; D007773:Lactates; D009566:Nitrates; D011773:Pyruvates; D002245:Carbon Dioxide; D000431:Ethanol; D012822:Silicon Dioxide; D007930:Leucine; D005947:Glucose