title: Thyroid hormone action: in vitro demonstration of putative receptors in isolated nuclei and soluble nuclear extracts.
abstract: Saturable binding activities for triiodothyronine were demonstrated in vitro with isolated nuclei and soluble nuclear extracts of rat liver, kidney, and cultured GH(1) cells. The binding activity can be extracted from nuclei in soluble form with no significant change in hormone affinity and has properties of a nonhistone protein.
mesh_terms: D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002458:Cell Fractionation; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007668:Kidney; D008099:Liver; D010911:Pituitary Neoplasms; D051381:Rats; D011920:Rats, Inbred WF; D011956:Receptors, Cell Surface / Q000187:drug effects*; D014284:Triiodothyronine / Q000378:metabolism*
chemical_list: D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D014284:Triiodothyronine