Preferential inhibition of the growth of virus-transformed cells in culture by rifazone-82, a new rifamycin derivative.
Rifazone-8(2), a new rifamycin derivative, is shown to preferentially inhibit the growth of virus-transformed chick cells in culture. Macromolecular synthesis and glucose uptake of transformed cells are also appreciably decreased in the presence of low concentrations of rifazone-8(2) where the normal cells appear unaffected. While rifazone-8(2) is shown to be a selective inhibitor of RNA-directed DNA polymerase in vitro, its action on the growth of transformed cells may involve some other mechanism.
D000818:Animals; D001358:Avian Sarcoma Viruses; D002455:Cell Division / Q000187:drug effects*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002642:Chick Embryo; D004254:DNA Nucleotidyltransferases; D005347:Fibroblasts; D005947:Glucose / Q000378:metabolism; D012294:Rifamycins / Q000494:pharmacology*
D012294:Rifamycins; D004254:DNA Nucleotidyltransferases; D005947:Glucose