Oxygen uptake by Treponema pallidum.
Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduced) to O(2). Evidence is consistent with the probability that this terminal electron-transport system is coupled to oxidative phosphorylation. The potential significance of these findings is discussed.
D000654:Amobarbital / Q000494:pharmacology; D000693:Anaerobiosis; D001386:Azides / Q000494:pharmacology; D001431:Bacteriological Techniques; D002746:Chlorpromazine / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D003576:Electron Transport Complex IV / Q000378:metabolism; D007919:Leptospira / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption; D011804:Quinolines; D012402:Rotenone; D013142:Spirochaeta / Q000378:metabolism; D014210:Treponema pallidum / Q000378:metabolism*
D001386:Azides; D003486:Cyanides; D004140:Dinitrophenols; D011804:Quinolines; D012402:Rotenone; D009243:NAD; D003576:Electron Transport Complex IV; D000654:Amobarbital; D002746:Chlorpromazine