Frequency dependence of dual negative feedback control of secretion of sympathetic neurotransmitter in guinea-pig vas deferens.
The secretion of sympathetic neurotransmitter in guinea-pig vas deferens appears to be normally controlled by two different mechanisms, one dependent and one independent of prostaglandin E. The efficiency of both control systems, as well as of exogenous prostaglandin E(2), is inversely related to nerve stimulation frequency.
D000818:Animals; D004558:Electric Stimulation; D005246:Feedback; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000032:analysis; D011453:Prostaglandins / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000502:physiology; D009435:Synaptic Transmission; D013779:Tetrodotoxin / Q000494:pharmacology; D014316:Tritium; D014649:Vas Deferens / Q000378:metabolism*
D011453:Prostaglandins; D014316:Tritium; D013779:Tetrodotoxin; D011188:Potassium; D009638:Norepinephrine; D010646:Phentolamine