Angiotensin II- and angiotensin 3-induced aldosterone release vivo in the rat.
The potential role of angiotensin II and its heptapeptide metabolite, des-aspartyl-angiotensin II, was studied in the conscious unanesthetized rat. Aldosterone release was induced by both peptides at physiologic doses (0.72 nanogram per minute). [I-Sarcosyl-8-alanyl]-angiotensin II (P-113 inhibited angiotensin II more effectively than des-aspartyl-angiotensin II (101 percent as compared to 82 percent). These results indicate that angiotensin controls aldosterone release in the rat and that des-aspartyl-angiotensin II (that is, angiotensin III) may be important in this sequence.
D000409:Alanine / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D012521:Sarcosine / Q000494:pharmacology
D000804:Angiotensin II; D000450:Aldosterone; D000409:Alanine; D012521:Sarcosine