Molecular modifications of anti-aldosterone compounds: effects on affinity of spirolactones for renal aldosterone receptors.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D003593:Cytoplasm / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000378:metabolism*; D007783:Lactones / Q000494:pharmacology; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists; D008901:Mineralocorticoids / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013148:Spironolactone / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014316:Tritium
D007783:Lactones; D000451:Mineralocorticoid Receptor Antagonists; D008901:Mineralocorticoids; D011956:Receptors, Cell Surface; D014316:Tritium; D013148:Spironolactone; D000450:Aldosterone; D003907:Dexamethasone; D011188:Potassium