Neuroblastoma: drug-induced differentiation increases proportion of cytoplasmic RNA that contains polyadenylic acid.
The production of cytoplasmic RNA that contains polyadenylic acid is increased, relative to total cytoplasmic RNA, in a neuroblastoma clone, NBE-(A), after induction of differentiation by 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone, an inhibitor of adenosine 3',5'-monophosphate phosphodiesterase. The amount of RNA that contains polyadenylic acid in cytoplasm may be greater in such differentiated neuroblastoma cells than in proliferating control cells.
D000123:Acetyltransferases / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D001921:Brain / Q000166:cytology; D002454:Cell Differentiation / Q000187:drug effects; D002645:Chickens; D002794:Choline; D002999:Clone Cells / Q000378:metabolism; D003470:Culture Media; D000242:Cyclic AMP; D003593:Cytoplasm / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D008858:Microscopy, Phase-Contrast; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D010726:Phosphodiesterase Inhibitors; D011119:Polynucleotides / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000378:metabolism; D014316:Tritium
D001593:Benzyl Compounds; D003470:Culture Media; D004987:Ethers; D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011119:Polynucleotides; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D014316:Tritium; D000249:Adenosine Monophosphate; D000242:Cyclic AMP; D000123:Acetyltransferases; D000241:Adenosine; D002794:Choline