Inhibition by dithiothreitol of the utilization of glutamine by carbamyl phosphate synthetase. Evidence for formation of hydrogen peroxide.
D000596:Amino Acids / Q000494:pharmacology; D000693:Anaerobiosis; D001665:Binding Sites; D002219:Carbamates; D002250:Carbon Radioisotopes; D004229:Dithiothreitol / Q000494:pharmacology*; D004355:Drug Stability; D004926:Escherichia coli / Q000201:enzymology*; D005972:Glutaminase / Q000037:antagonists & inhibitors; D005973:Glutamine / Q000378:metabolism* / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000378:metabolism* / Q000494:pharmacology; D007651:Keto Acids / Q000494:pharmacology; D046911:Macromolecular Substances; D010084:Oxidation-Reduction; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D014316:Tritium; D014631:Valerates / Q000494:pharmacology
D000596:Amino Acids; D002219:Carbamates; D002250:Carbon Radioisotopes; D007651:Keto Acids; D046911:Macromolecular Substances; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D014631:Valerates; D005973:Glutamine; D014316:Tritium; D006861:Hydrogen Peroxide; D010770:Phosphotransferases; D005972:Glutaminase; D004229:Dithiothreitol