The behaviour of carcinoma of the large bowel in man following transplantation into immune deprived mice.
The growth of carcinoma of the human large bowel was studied in the first 2 passages in immune deprived mice. The tumours were obtained from large bowel resections on 3 people. There was a strong histological similarity between the patient's tumour and the tumour that grew subcutaneously in the mice 2-8 months after implantation. One dissimilarity observed was a higher mitotic index in some of the tumours growing in the immune deprived animals. In the second passage of the bowel tumours, cells were implanted into groups of 8-10 animals in the following sites: subcutaneous, intramuscular, intravenous, intrahepatic, intraperitoneal and intrathoracic. Growth of tumour was observed from all 3 tumours when they were implanted subcutaneously, intramuscularly, intraperitoneally and intrathoracically. Infiltration of muscle by tumour was a frequent finding. Lung metastases developed after intravenous injection of cells in 1 of the 3 tumours. In none of the 3 tumours did growth follow injection of cells directly into the substance of the liver. On no occasions were spontaneous metastases observed.
D000009:Abdominal Muscles / Q000473:pathology; D000230:Adenocarcinoma / Q000276:immunology; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D003110:Colonic Neoplasms / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000528:radiation effects; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008099:Liver; D008113:Liver Neoplasms; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D008938:Mitosis; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010994:Pleura; D011830:Radiation Effects; D012004:Rectal Neoplasms / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology; D012883:Skin Ulcer / Q000473:pathology; D013934:Thymectomy