title: Phosphorylation of muscle membranes: identification of a membrane-bound protein kinase.
abstract: A membrane-bound protein kinase occurs in membranes derived from rat skeletal muscle and appears limited to a surface membrane fraction. The enzyme is magnesium dependent, is only minimally stimulated by cyclic nucleotides, and phosphorylates serine and to a lesser extent threonine residues of three membrane proteins with molecular weights of less than 30,000.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002458:Cell Fractionation; D002462:Cell Membrane / Q000201:enzymology; D000242:Cyclic AMP; D006152:Cyclic GMP; D004591:Electrophoresis, Polyacrylamide Gel; D004789:Enzyme Activation; D008274:Magnesium; D008970:Molecular Weight; D009132:Muscles / Q000166:cytology / Q000201:enzymology*; D010085:Oxidative Phosphorylation; D010455:Peptides / Q000378:metabolism; D010761:Phosphorus Radioisotopes; D011494:Protein Kinases / Q000302:isolation & purification* / Q000378:metabolism; D051381:Rats; D012694:Serine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism
chemical_list: D010455:Peptides; D010761:Phosphorus Radioisotopes; D013912:Threonine; D012694:Serine; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D011494:Protein Kinases; D006152:Cyclic GMP; D008274:Magnesium