Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).
Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance.
D000818:Animals; D003374:Coumarins / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D003574:Cytochrome c Group; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D014644:Genetic Variation; D006824:Hybridization, Genetic; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology
D003374:Coumarins; D003574:Cytochrome c Group; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D003579:Cytochrome Reductases; D010634:Phenobarbital