SV40 virus transformation of mouse 3T3 cells does not specifically enhance sugar transport.
The apparent enhancement of 2-deoxy-D-glucose uptake by mouse 3T3 cells accompanying transformation by SV40 virus is not due primarily to an effect on the transport process but to enhanced phosphorylation of the sugar by intracellular kinases. Moreover, the effect is not specifically a function of the presence of the viral genome, but is a reflection of the overall growth rate and physiological state of the cell.
D000818:Animals; D001692:Biological Transport; D002247:Carbon Isotopes; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D010085:Oxidative Phosphorylation; D013539:Simian virus 40; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D002247:Carbon Isotopes; D014316:Tritium; D005947:Glucose; D013936:Thymidine