Transport of methotrexate into normal haemopoietic cells and into leukaemic cells and its effects on DNA synthesis.
D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D002250:Carbon Radioisotopes; D046508:Culture Techniques; D000242:Cyclic AMP; D004247:DNA / Q000096:biosynthesis*; D003609:Dactinomycin / Q000494:pharmacology; D003857:Deoxyuridine / Q000378:metabolism; D005492:Folic Acid / Q000378:metabolism; D006801:Humans; D037102:Lectins; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D007951:Leukemia, Myeloid / Q000378:metabolism; D008213:Lymphocyte Activation; D008727:Methotrexate / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008938:Mitosis / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors; D011691:Puromycin / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis; D013806:Theophylline / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D002250:Carbon Radioisotopes; D037102:Lectins; D010726:Phosphodiesterase Inhibitors; D014316:Tritium; D003609:Dactinomycin; D011691:Puromycin; D012313:RNA; D004247:DNA; D005492:Folic Acid; D013806:Theophylline; D000242:Cyclic AMP; D013936:Thymidine; D003857:Deoxyuridine; D008727:Methotrexate