Nineteen paracentric chromosomal inversions in mice.
Using mutagens on sperm and spermatids we have produced nineteen chromosomal inversions in mice. The levels of radiation and chemical mutagen we used induced inversions in about one per cent of the animals screened. Nine inversions have been transmitted through successive generations, and the particular frequency of first meiotic anaphase bridges manifested by each inversion remained constant. The cytological properties of first meiotic anaphases varied considerably among the inversions. Chromosomal locations of five inversions are known. Four of the five are fully viable in homozygous condition.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006720:Homozygote; D007248:Infertility, Male; D008297:Male; D008698:Mesylates / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D011831:Radiation Genetics; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D014265:Triethylenemelamine / Q000494:pharmacology
D008698:Mesylates; D009153:Mutagens; D014265:Triethylenemelamine