title: Stimulation of aryl hydrocarbon hydroxylase induction in cell cultures by interferon.
abstract: In cell cultures previously treated with homologous interferon, the magnitude of antiviral activity and the degree of stimulation of aryl hydrocarbon hydroxylase induction appear to be directly related. In a highly purified mouse interferon preparation, the factor stimulating hydroxylase induction and the factor directing antiviral activity are inactivated by heating to 70 C or by treating with trypsin. Also, both activities demonstrate species specificity.
mesh_terms: D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D002460:Cell Line; D002478:Cells, Cultured; D004789:Enzyme Activation; D004790:Enzyme Induction / Q000187:drug effects*; D006358:Hot Temperature; D007372:Interferons / Q000494:pharmacology*; D008099:Liver; D051379:Mice; D006899:Mixed Function Oxygenases / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D013268:Stimulation, Chemical; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development; D010948:Viral Plaque Assay
chemical_list: D001551:Benz(a)Anthracenes; D007372:Interferons; D006899:Mixed Function Oxygenases; D014357:Trypsin