title: Inactivation of isocitrate lyase during myxospore development in Myxococcus xanthus.
abstract: The inactivation of isocitrate lyase which occurs during late stages of myxospore formation in Myxococcus xanthus was studied. Several findings are reported. (i) Protein synthesis is required over a specific time interval in order for isocitrate lyase inactivation to occur at a later time. (ii) Metabolic energy is required at all times during myxospore development if the inactivation is to occur. (iii) It was possible to inhibit protein turnover to a considerable extent without affecting the net loss in isocitrate lyase activity.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000476:Alkanesulfonates / Q000494:pharmacology; D000693:Anaerobiosis; D001386:Azides / Q000494:pharmacology; D001419:Bacteria / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D002474:Cell-Free System; D002701:Chloramphenicol / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D007523:Isocitrates; D009154:Mutation; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D010618:Phenanthrolines / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D013171:Spores, Bacterial / Q000254:growth & development*; D013997:Time Factors; D014633:Valine / Q000378:metabolism
chemical_list: D000476:Alkanesulfonates; D001386:Azides; D001426:Bacterial Proteins; D002250:Carbon Radioisotopes; D004140:Dinitrophenols; D007523:Isocitrates; D010618:Phenanthrolines; D002701:Chloramphenicol; D000255:Adenosine Triphosphate; D010447:Peptide Hydrolases; D007652:Oxo-Acid-Lyases; D014633:Valine; D012293:Rifampin