Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. VII. Stimulation of benzphetamine N-demethylation by lipid and detergent.
D000818:Animals; D001589:Benzphetamine; D002793:Cholic Acids / Q000494:pharmacology; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003579:Cytochrome Reductases / Q000378:metabolism; D003574:Cytochrome c Group; D003840:Deoxycholic Acid / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D008055:Lipids / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D002793:Cholic Acids; D003574:Cytochrome c Group; D003902:Detergents; D008055:Lipids; D010713:Phosphatidylcholines; D003840:Deoxycholic Acid; D001589:Benzphetamine; D011092:Polyethylene Glycols; D003577:Cytochrome P-450 Enzyme System; D010089:Oxidoreductases, N-Demethylating; D003579:Cytochrome Reductases; D010634:Phenobarbital