title: Intracellular cyclic AMP concentration responds specifically to growth regulation by serum.
abstract: Intracellular concentrations of cyclic AMP increase when cells are deprived of serum. Studies with the mouse fibroblast line 3T3, an SV40-transformed subline of 3T3, and six different revertant lines derived from this clone show that a marked increase in cyclic AMP occurs only when the serum concentration is reduced below the minimum necessary for growth of a given line. Conversely, density-dependent inhibition of growth is not accompanied by an increase in cyclic AMP concentration in any line.
mesh_terms: D000818:Animals; D001769:Blood; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000378:metabolism*; D003260:Contact Inhibition; D003470:Culture Media; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D005347:Fibroblasts / Q000254:growth & development* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D013539:Simian virus 40
chemical_list: D003470:Culture Media; D000242:Cyclic AMP