The effect of 3',5'-adenosine monophosphate on granulocyte adhesion.
Human granulocyte adhesion to glass capillary tubes was tested in the presence of agents that increase intracellular levels of cyclic 3',5'-adenosine monophosphate (cAMP). Adhesion was significantly reduced by 10(-3)-10(-4) M dibutyryl cAMP, 10(-4)-10(-6) M prostaglandin E(1) (PGE(1)), 10(-4)-10(-6) M histamine, or 10(-3) M theophylline. Adhesion was not suppressed by 10(-4) M theophylline unless it was combined with PGE(1) or histamine. Eosinophil and basophil adhesion was especially sensitive to suppression by the above agents. These findings suggest that intracellular cAMP may play a role in regulation of adhesiveness of human basophils, eosinophils, and neutrophils.
D001491:Basophils / Q000187:drug effects; D003994:Bucladesine / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology*; D003864:Depression, Chemical; D004357:Drug Synergism; D004804:Eosinophils / Q000187:drug effects; D005898:Glass; D006098:Granulocytes / Q000187:drug effects*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D011453:Prostaglandins; D003994:Bucladesine; D006632:Histamine; D013806:Theophylline; D000242:Cyclic AMP