Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.
Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.
D000818:Animals; D002087:Butyrates; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005246:Feedback; D007545:Isoproterenol / Q000494:pharmacology; D008223:Lymphoma; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000096:biosynthesis*; D010770:Phosphotransferases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism
D002087:Butyrates; D003609:Dactinomycin; D003513:Cycloheximide; D000242:Cyclic AMP; D010770:Phosphotransferases; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases; D007545:Isoproterenol