Neutralizing activity in isolated serum antibody fractions from visna-infected sheep.
The neutralization technique was used to detect specific antibodies against visna virus in isolated immunoglobulin (Ig) G(1), IgG(2), and IgM fractions of visna-infected sheep serum. The neutralizing antibodies were present chiefly in the IgG(1) class. Low amount of activity was demonstrated in the IgM class, but no significant activity was seen in the IgG(2) class.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D003168:Complement Fixation Tests; D006386:Hemagglutination Tests; D007106:Immune Sera; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D009500:Neutralization Tests; D012328:RNA Viruses / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D012756:Sheep; D014790:Visna-maedi virus / Q000276:immunology*
D000914:Antibodies, Viral; D007106:Immune Sera; D007074:Immunoglobulin G; D007075:Immunoglobulin M