Insecticide inhibition of 5alpha-dihydrotestosterone binding in the rat ventral prostate.
The chlorinated hydrocarbon insecticides dieldrin and o,p'-DDT inhibit binding of 5alpha-dihydrotestosterone to specific receptor proteins in rat prostate cytosol. Dieldrin is less inhibitory than o,p'-DDT.
D000818:Animals; D002247:Carbon Isotopes; D003600:Cytosol / Q000378:metabolism; D003634:DDT / Q000494:pharmacology*; D004026:Dieldrin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D002247:Carbon Isotopes; D011956:Receptors, Cell Surface; D014316:Tritium; D013739:Testosterone; D003634:DDT; D004026:Dieldrin