Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.
The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.
D000818:Animals; D002247:Carbon Isotopes; D000242:Cyclic AMP / Q000494:pharmacology*; D003920:Diabetes Mellitus / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D005215:Fasting; D064429:Fatty Acid Synthases / Q000096:biosynthesis*; D005934:Glucagon / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats
D002247:Carbon Isotopes; D007328:Insulin; D005934:Glucagon; D000242:Cyclic AMP; D064429:Fatty Acid Synthases; D007930:Leucine