title: Behavior of three types of ribovirus-like particles in segregating hamster times mouse somatic hybrids.
abstract: An electron microscopic study of somatic hybrids resulting from a cross between hamster melanoma cells harboring R-type particles and mouse fibroblasts harboring intracisternal A-type and (mostly) immature C-type particles was performed. The major findings are: (a) hybrid cells that retain a large fraction of both hamster and mouse chromosomes produce all three types of particles; (b) the loss of mouse chromosomes is followed by that of intracisternal A- and C-type particles; (c) the continued production of A- and C-type particles is dependent on the retention of different mouse chromosomes; (d) the mixed intracellular population of R- and A-particles comprises a small number of complex structures in which the two types of virions are enclosed within a common envelope.
mesh_terms: D000818:Animals; D002875:Chromosomes; D002999:Clone Cells; D006224:Cricetinae; D005347:Fibroblasts; D006822:Hybrid Cells / Q000382:microbiology*; D007621:Karyotyping; D008545:Melanoma; D051379:Mice; D008854:Microscopy, Electron; D009858:Oncogenic Viruses / Q000302:isolation & purification* / Q000648:ultrastructure; D012328:RNA Viruses / Q000302:isolation & purification* / Q000648:ultrastructure; D012190:Retroviridae / Q000302:isolation & purification / Q000648:ultrastructure