Renin-like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli.
1. Renin-like activity was found in rat submaxillary glands.2. This activity was destroyed by boiling, was non-dialyzable and showed an optimum at approximately 50 degrees C.3. Renin-like activity in the submaxillary gland was not diminished 24 h after nephrectomy but was considerably reduced after ligature of the submaxillary duct.4. Renin-like activity in the submaxillary gland was reduced following food-deprivation, water-deprivation or hypovolemia.5. Renin-like activity in the rat submaxillary gland was increased after isoproterenol administration but not following pilocarpine.6. Renin-like activity in the rat submaxillary gland was increased considerably by administration of NaCl or KCl, as well as following adrenalectomy.7. Chlorothiazide and ouabain increased submaxillary renin-like activity but diazoxide did not affect this activity.
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D002740:Chlorothiazide / Q000494:pharmacology; D003981:Diazoxide / Q000494:pharmacology; D006018:Glycols / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D007668:Kidney / Q000502:physiology; D008297:Male; D009392:Nephrectomy; D010042:Ouabain / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012083:Renin / Q000494:pharmacology*; D012463:Saliva / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D013217:Starvation; D013363:Submandibular Gland / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014868:Water Deprivation
D006018:Glycols; D010862:Pilocarpine; D000804:Angiotensin II; D010042:Ouabain; D002740:Chlorothiazide; D012964:Sodium; D012083:Renin; D007545:Isoproterenol; D003981:Diazoxide; D011188:Potassium