Spin-labeled sulfonyl fluorides as active site probes of protease structure. II. Spin label syntheses and enzyme inhibition.
D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000494:pharmacology*; D001665:Binding Sites; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D005069:Evaluation Studies as Topic; D005461:Fluorine / Q000494:pharmacology; D006868:Hydrolysis; D008722:Methods; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors; D014105:Tosyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism; D014361:Trypsin Inhibitors / Q000378:metabolism*
D001557:Benzenesulfonates; D003497:Cyclic N-Oxides; D010880:Piperidines; D014105:Tosyl Compounds; D014361:Trypsin Inhibitors; D005461:Fluorine; D002918:Chymotrypsin; D014357:Trypsin