title: Some aspects of the inhibition of the action of antidiuretic hormone by lithium ions in the rat kidney and bladder of the toad Bufo marinus.
abstract: 1. The effect of intravenous infusions of various ions on the antidiuretic action of antidiuretic hormone has been studied in rats.2. Lithium (13 mmol/l.) reversibly inhibits the antidiuretic responses. Similar concentrations of potassium, rubidium, strontium, magnesium, choline and calcium do not. Lithium has a similar effect on the antidiuretic activity of oxytocin.3. The inhibition is not simply related to blood nor whole body lithium concentrations.4. Lithium (2 mmol/l.) in contact with the serosal surface also inhibits the transport of water facilitated by either 0.5 U/l. antidiuretic hormone or 1.1 mmol/l. cyclic adenosine monophosphate in the isolated toad bladder.5. Choline (2 mmol/l.) on the serosal surface also inhibits the transport of water facilitated by vasopressin in the toad bladder.
mesh_terms: D000818:Animals; D002024:Bufo marinus; D002794:Choline / Q000378:metabolism; D000242:Cyclic AMP / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006029:Glycosuria; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009994:Osmolar Concentration; D010121:Oxytocin / Q000494:pharmacology; D010783:Photometry; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D001743:Urinary Bladder / Q000187:drug effects*; D014667:Vasopressins / Q000037:antagonists & inhibitors*
chemical_list: D014667:Vasopressins; D010121:Oxytocin; D008094:Lithium; D012964:Sodium; D000242:Cyclic AMP; D005947:Glucose; D002794:Choline; D011188:Potassium