The enhancement by caffeine of alkylation-induced cell death, mutations and chromosomal aberrations in Chinese hamster cells, as a result of inhibition of post-replication DNA repair.
D000478:Alkylation; D000818:Animals; D001375:Azaguanine; D002110:Caffeine / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects*; D004261:DNA Replication; D006367:HeLa Cells; D006801:Humans; D008168:Lung; D008698:Mesylates / Q000494:pharmacology; D009150:Mustard Compounds / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects*; D009607:Nitrosourea Compounds / Q000494:pharmacology; D013455:Sulfur / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D008698:Mesylates; D009150:Mustard Compounds; D009607:Nitrosourea Compounds; D014316:Tritium; D002110:Caffeine; D013455:Sulfur; D004247:DNA; D001375:Azaguanine; D013936:Thymidine