Transient inhibition of polyoma virus synthesis by Sendai virus (parainfluenza I). I. Demonstration and nature of the inhibition by inactivated virus.
Superinfection of polyoma virus-infected mouse embryo cells by beta-propiolactone-inactivated Sendai virus resulted in a 90% inhibition of the synthesis of infectious polyoma progeny. The interference is dependent upon the time of superinfection and the concentration of the inactivated virus. The inhibition of polyoma virus synthesis is transient in nature since normal synthesis of polyoma progeny virus is seen upon prolonged incubation. Interferon does not appear to be implicated in the interference. Various aspects of the biological and synthetic capabilities of beta-propiolactone-inactivated Sendai virus are also described.
D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D046508:Culture Techniques; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D006382:Hemadsorption; D006571:Heterocyclic Compounds; D007372:Interferons / Q000032:analysis; D007668:Kidney; D007783:Lactones / Q000494:pharmacology; D051379:Mice; D010222:Parainfluenza Virus 1, Human / Q000187:drug effects / Q000254:growth & development*; D011120:Polyomavirus / Q000254:growth & development* / Q000378:metabolism; D011422:Propionates; D012367:RNA, Viral / Q000096:biosynthesis; D012698:Serologic Tests; D013997:Time Factors; D014316:Tritium; D014529:Uridine / Q000378:metabolism; D014762:Viral Interference; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication
D006571:Heterocyclic Compounds; D007783:Lactones; D011422:Propionates; D012367:RNA, Viral; D014764:Viral Proteins; D014316:Tritium; D007372:Interferons; D014529:Uridine