Nerve growth factor: relationship to the cyclic AMP system of sensory ganglia.
Nerve growth factor and N(6),O(2)' dibutyryl adenosine 3',5'-monophosphate both stimulate neurite elongation by explanted ganglia. However, the addition of nerve growth factor does not lead to increased amounts of adenosine 3',5'-monophosphate in intact ganglia, nor does it stimulate adenylate cyclase activity in broken ganglia cells.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002642:Chick Embryo; D000242:Cyclic AMP / Q000096:biosynthesis*; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D009414:Nerve Growth Factors / Q000494:pharmacology*; D010759:Phosphorus Isotopes
D009414:Nerve Growth Factors; D010759:Phosphorus Isotopes; D000255:Adenosine Triphosphate; D000242:Cyclic AMP; D000262:Adenylyl Cyclases