Diphenylhydantoin: effects on calcium metabolism in the chick.
Rickets, hypocalcemia, decreased duodenal calcium transport, and reduction of calcium binding protein have been produced in chicks treated with diphenylhydantoin. These effects are directly related to diphenylhydantoin dose and inversely related to the intake of vitamin D(3) (cholecalciferol).
D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002645:Chickens; D002762:Cholecalciferol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000378:metabolism; D006996:Hypocalcemia / Q000139:chemically induced; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D010672:Phenytoin / Q000009:adverse effects / Q000494:pharmacology*; D011485:Protein Binding; D012279:Rickets / Q000139:chemically induced; D014808:Vitamin D Deficiency / Q000378:metabolism
D002132:Calcium Radioisotopes; D002762:Cholecalciferol; D010672:Phenytoin; D002118:Calcium