Independent segregation of the H-2 locus and the locus for responsiveness to histamine-sensitizing factor.
The inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli was examined in (SWR/J x CBA/J)F(1) x CBA/J backcross mice. We found that about half of the backcross mice inherited this responsiveness in both sexes. There was no linkage between the inheritance of responsiveness to histamine-sensitizing factor and the H-2(q) locus from the sensitive SW/J progenitor.
D000818:Animals; D001886:Bordetella pertussis; D005260:Female; D008040:Genetic Linkage; D006632:Histamine; D006648:Histocompatibility; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010567:Pertussis Vaccine
D010567:Pertussis Vaccine; D006632:Histamine