Inhibition of purine ribonucleotide and phosphoribosyl pyrophosphate synthesis by 6-cyclopentylthio-9-hydroxymethylpurine and structurally related compounds.
D000225:Adenine / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D003517:Cyclopentanes; D006147:Guanine / Q000378:metabolism; D007042:Hypoxanthines / Q000378:metabolism; D007938:Leukemia / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000096:biosynthesis*; D010428:Pentosephosphates / Q000096:biosynthesis*; D010756:Phosphoric Acids / Q000096:biosynthesis; D011685:Purine Nucleotides / Q000096:biosynthesis*; D011687:Purines / Q000494:pharmacology*; D012265:Ribonucleotides / Q000096:biosynthesis*
D002250:Carbon Radioisotopes; D003517:Cyclopentanes; D007042:Hypoxanthines; D009943:Organophosphorus Compounds; D010428:Pentosephosphates; D010756:Phosphoric Acids; D011685:Purine Nucleotides; D011687:Purines; D012265:Ribonucleotides; C007203:6-cyclopentylthio-9-hydroxymethylpurine; D006147:Guanine; D000225:Adenine