Glia-induced morphological differentiation in neuroblastoma cells.
Glial cells release a factor into their culture medium that induces a high degree of morphological differentiation in neuroblastoma cells under normal growth conditions. This phenomenon is not correlated with a change in intracellular adenosine 3':5'-cyclic monophosphate or in the rate of cell growth. Media from other cell lines tested induce less morphological differentiation or have no effect.
D000818:Animals; D006528:Carcinoma, Hepatocellular; D002454:Cell Differentiation; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells; D006224:Cricetinae; D003470:Culture Media; D000242:Cyclic AMP / Q000032:analysis; D005333:Fetus; D005347:Fibroblasts; D006801:Humans; D007668:Kidney; D008113:Liver Neoplasms; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009447:Neuroblastoma; D009457:Neuroglia; D011120:Polyomavirus; D051381:Rats; D013539:Simian virus 40
D003470:Culture Media; D000242:Cyclic AMP