Intracranial reticulum cell sarcoma associated with immunoglobulin A deficiency.
A case is reported of a 46 year old woman who died after a five month illness characterized by focal neurological signs, evidence of meningeal irritation, and the finding of `blast' cells in the CSF. Immunoglobulin A was consistently absent from her serum and secretions. Necropsy showed extensive infiltration by a reticulum-cell sarcoma of the subarachnoid space, with tumour nodules on several cranial nerves and tumour infiltration of the tuber cinereum. The significance of the association between immunoglobulin A deficiency and neoplasia is discussed.
D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D003391:Cranial Nerves / Q000473:pathology; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000473:pathology; D007070:Immunoglobulin A / Q000032:analysis* / Q000134:cerebrospinal fluid; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use
D002556:Cerebrospinal Fluid Proteins; D007070:Immunoglobulin A; D000324:Adrenocorticotropic Hormone; D011239:Prednisolone; D008727:Methotrexate