Adenosine 3',5'-monophosphate in pancreatic islets: glucose-induced insulin release.
Glucose-induced release of insulin from perifused rat islets is associated with elevated islet adenosine 3',5'-monophosphate. If values for adenosine 3',5'-monophosphate are compared to insulin release during theophylline or glucose stimulation and theophylline plus glucose stimulation, it suggests a minor role for adenosine 3',5'-monophosphate in directly stimulating insulin release but a prominent role in modulating glucose-induced release of insulin.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism* / Q000502:physiology; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D013806:Theophylline / Q000494:pharmacology
D007328:Insulin; D013806:Theophylline; D000242:Cyclic AMP; D005947:Glucose