Stimulation of peripheral blood lymphocytes by herpes simplex virus in vitro.
A method for stimulating sensitized lymphocytes by inactivated herpes simplex virus was established by using cultures of washed whole blood cells. The development of the immune response of herpes simplex virus-infected guinea pigs was examined at different times in the 4-month period after infection. Humoral and cellular immune responses were compared in individual animals by measuring lymphocyte stimulation ratios and neutralizing serum antibodies.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D000956:Antigens, Viral; D001773:Blood Cells; D001798:Blood Proteins / Q000032:analysis; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D006168:Guinea Pigs; D007109:Immunity; D007111:Immunity, Cellular; D007114:Immunization; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008722:Methods; D009500:Neutralization Tests; D018139:Simplexvirus / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014779:Virus Replication
D000914:Antibodies, Viral; D000956:Antigens, Viral; D001798:Blood Proteins; D014316:Tritium; D004247:DNA; D013936:Thymidine