Pemoline and magnesium hydroxide: lack of effect on RNA and protein synthesis.
Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich ascites carcinoma cells.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D006878:Hydroxides; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009713:Nucleotidyltransferases / Q000378:metabolism*; D010080:Oxazoles / Q000494:pharmacology*; D010389:Pemoline / Q000494:pharmacology; D012334:RNA, Neoplasm / Q000096:biosynthesis*; D051381:Rats; D014529:Uridine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D000697:Central Nervous System Stimulants; D006878:Hydroxides; D009363:Neoplasm Proteins; D010080:Oxazoles; D012334:RNA, Neoplasm; D010389:Pemoline; D009713:Nucleotidyltransferases; D007930:Leucine; D014633:Valine; D008274:Magnesium; D014529:Uridine