title: Actinomycin-D enhancement of glutamine synthetase activity in chick embryo retinas cultured in the presence of cortisol.
abstract: Cortisol can prematurely induce glutamine synthetase activity in the chick embryo retina. Under appropriate conditions, this effect can be enhanced by addition of low levels of actinomycin D; this enhancement is reversibly inhibited by cycloheximide. The magnitude of the effect is a function of time of exposure to hormone as well as antibiotic and is also a function of the age of the embryo; within the limits of the present study it did not appear to be a function of actinomycin-D concentration. The data are discussed in terms of current ideas of possible control mechanisms in animal cells.
mesh_terms: D000367:Age Factors; D000818:Animals; D002642:Chick Embryo; D003470:Culture Media; D046508:Culture Techniques; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology*; D004790:Enzyme Induction; D005974:Glutamate-Ammonia Ligase / Q000032:analysis* / Q000037:antagonists & inhibitors; D006854:Hydrocortisone / Q000494:pharmacology*; D008722:Methods; D012160:Retina / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D013997:Time Factors
chemical_list: D003470:Culture Media; D003609:Dactinomycin; D003513:Cycloheximide; D005974:Glutamate-Ammonia Ligase; D006854:Hydrocortisone