[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine (NNMG) with respect to mutagenesis. 3. On the inhibition of nucleic acid synthesis and cell-free protein biosynthesis by NNMG and the appearance of resistant Escherichia coli cells after treatment with NNMG].
D001426:Bacterial Proteins / Q000096:biosynthesis*; D002474:Cell-Free System; D004269:DNA, Bacterial / Q000096:biosynthesis*; D003864:Depression, Chemical; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D008745:Methylation; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009603:Nitroso Compounds / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis*; D014316:Tritium; D014498:Uracil / Q000378:metabolism
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D006146:Guanidines; D009153:Mutagens; D009603:Nitroso Compounds; D012329:RNA, Bacterial; D014316:Tritium; D014498:Uracil
Zum Wirkungsmechanismus von 1-Nitroso-3-nitro-1-methylguanidin (NNMG) bei der Mutationsauslösung. 3. Uber die Hemmung der nucleinsäuresynthese und zellfreien Proteinbiosynthese durch NNMG und über Resistenzerscheinungen von Escherichia coli-Zellen nach Behandlung mit NNMG.