title: Increased dihydrofolate reductase synthesis in Diplococcus pneumoniae following translatable alteration of the structural gene. II. Individual and dual effects on the properties and rate of synthesis of the enzyme.
mesh_terms: D002874:Chromosome Mapping; D004352:Drug Resistance, Microbial; D005796:Genes; D008727:Methotrexate / Q000494:pharmacology; D009154:Mutation; D013296:Streptococcus pneumoniae / Q000201:enzymology; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis*
chemical_list: D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate