Role of immunologic disturbance in human oncogenesis: some facts and fancies.
A brief review is presented of the evidence linking the development of certain types of neoplasms, and of the malignant lymphomas in particular, to chronic immunosuppression in animals and man and to the naturally occurring human immunologic deficiency states. The discussion then focuses on Hodgkin's disease and considers recent evidence concerning the relation between the clinical stage of the disease and its associated defect in cell-mediated immunity. Finally, the prior occurrence of infectious mononucleosis in some cases of Hodgkin's disease is considered in the context of the hypothesis that the neoplastic cells of Hodgkin's disease may evolve from a chronic immunologic reaction, analogous to that of graft-versus-host, stemming from the induction of antigenic alteration in a subpopulation of lymphocytes by certain types of non-neoplastic viral infections.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000818:Animals; D000831:Animals, Newborn; D000941:Antigens; D000961:Antilymphocyte Serum / Q000009:adverse effects; D000963:Antimetabolites / Q000009:adverse effects; D002471:Cell Transformation, Neoplastic; D006087:Graft vs Host Reaction; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007244:Infectious Mononucleosis / Q000150:complications; D016030:Kidney Transplantation; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000209:etiology; D009369:Neoplasms / Q000209:etiology*; D009578:Nitrobenzenes; D012882:Skin Tests; D013934:Thymectomy; D014777:Virus Diseases / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000941:Antigens; D000961:Antilymphocyte Serum; D000963:Antimetabolites; D009578:Nitrobenzenes