title: Comparative trial of serotonin antagonists in the management of migraine.
abstract: The effectiveness of five different serotonin antagonists in the prevention of migraine was compared in 290 patients followed for periods of up to three years. Methysergide 3-6 mg. daily was most effective, with 20% of treated patients becoming headache-free and a further 44% remaining more than "half improved." The corresponding figures for BC105 were 10% and 40%, respectively.The results with BC105 were significantly better than those with placebo (P<0.02). The total improvement rates with methdilazine (45%) and cyproheptadine (43%) were better than those with placebo (32%) but did not achieve statistical significance. A new preparation, methylergol carbamide maleate, which is chemically related to methysergide, did not give better results than placebo.
mesh_terms: D002986:Clinical Trials as Topic; D003533:Cyproheptadine / Q000627:therapeutic use*; D004873:Ergolines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008784:Methysergide / Q000009:adverse effects / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000188:drug therapy*; D009120:Muscle Cramp / Q000139:chemically induced; D009325:Nausea / Q000139:chemically induced; D010640:Phenothiazines / Q000627:therapeutic use; D010919:Placebos; D011759:Pyrrolidines / Q000627:therapeutic use; D012702:Serotonin Antagonists; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D004873:Ergolines; D006634:Histamine H1 Antagonists; D010640:Phenothiazines; D010919:Placebos; D011759:Pyrrolidines; D012702:Serotonin Antagonists; D013876:Thiophenes; D003533:Cyproheptadine; D008784:Methysergide