The interference of chloramphenicol and thiamphenicol with the biogenesis of mitochondria in animal tissues. A possible clue to the toxic action.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002701:Chloramphenicol / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000096:biosynthesis; D008115:Liver Regeneration / Q000187:drug effects; D008930:Mitochondria, Liver / Q000187:drug effects; D001678:Organelle Biogenesis; D011817:Rabbits; D051381:Rats; D013839:Thiamphenicol / Q000633:toxicity*
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D003576:Electron Transport Complex IV; D013839:Thiamphenicol