title: Posttranscriptional control in the steroid-mediated induction of hepatic tyrosine transaminase.
abstract: The purine analog azaguanine does not inhibit the initial induction of hepatic tyrosine transaminase by hydrocortisone. However, the continued induced synthesis of tyrosine transaminase, elicited by repeated doses of hydro-cortisone, is inhibited approximately 64 percent in the presence of the analog after 7 to 8 hours and appears to be almost completely inhibited by 9 to 10 hours; this suggests that the induction cycle involves the activation and renewal of a pool of preexisting messenger RNA.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001375:Azaguanine / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005815:Genetic Code; D006854:Hydrocortisone / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D012333:RNA, Messenger; D051381:Rats; D014316:Tritium; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
chemical_list: D012333:RNA, Messenger; D014316:Tritium; D014444:Tyrosine Transaminase; D007930:Leucine; D001375:Azaguanine; D006854:Hydrocortisone