The development of commercial processes for the production of 6-aminopenicillanic acid (6-APA).
D000215:Acylation; D000581:Amidohydrolases / Q000378:metabolism; D000596:Amino Acids / Q000096:biosynthesis / Q000138:chemical synthesis; D001230:Aspergillus / Q000201:enzymology; D003470:Culture Media; D003500:Cyclization; D004345:Drug Industry; D005285:Fermentation; D006868:Hydrolysis; D010397:Penicillanic Acid / Q000096:biosynthesis / Q000138:chemical synthesis; D010406:Penicillins / Q000138:chemical synthesis* / Q000378:metabolism; D010407:Penicillium / Q000201:enzymology / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis*
D000596:Amino Acids; D003470:Culture Media; D010406:Penicillins; D013844:Thiazoles; D010397:Penicillanic Acid; D000581:Amidohydrolases