title: Experience with pericyazine in profoundly and severely retarded children.
abstract: The effectiveness of pericyazine in severe behavioural disorders was evaluated in 15 profoundly and severely retarded children. Pericyazine provided significant improvement in such parameters as co-operation, temper, purposeless activities, hyperactivity, communication and mood. It proved to be statistically superior to the minor tranquillizers in improving co-operation and helpfulness, temper, mood, the understanding of commands and table manners, and in reducing self-abusiveness and abusiveness to staff. The safety of this agent was confirmed and photosensitivity was not found to be associated with its use.
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy*; D008297:Male; D009570:Nitriles / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D010919:Placebos; D011581:Psychological Tests; D013997:Time Factors; D014149:Tranquilizing Agents / Q000627:therapeutic use*
chemical_list: D009570:Nitriles; D010640:Phenothiazines; D010880:Piperidines; D010919:Placebos; D014149:Tranquilizing Agents