Inhibition of folate biosynthesis and function as a basis for chemotherapy.
D062365:Aminobenzoates / Q000096:biosynthesis; D000818:Animals; D001665:Binding Sites; D001692:Biological Transport; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004926:Escherichia coli / Q000378:metabolism; D005492:Folic Acid / Q000096:biosynthesis*; D005493:Folic Acid Antagonists; D005971:Glutamates / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007778:Lactobacillus / Q000378:metabolism; D002955:Leucovorin; D008727:Methotrexate / Q000494:pharmacology; D009243:NAD; D009249:NADP; D011621:Pteridines / Q000096:biosynthesis; D011743:Pyrimidines / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*
D062365:Aminobenzoates; D005493:Folic Acid Antagonists; D005971:Glutamates; D011621:Pteridines; D011743:Pyrimidines; D013449:Sulfonamides; D009243:NAD; D009249:NADP; D005492:Folic Acid; D002955:Leucovorin; D008727:Methotrexate