The dental defects of vitamin D-resistant rickets.
Clinical, roentgenographic and morphologic features of teeth from patients with vitamin D-resistant rickets are described based on a study of 28 teeth from 5 patients. Clinically normal teeth become symptomatic and develop roentgenographic evidence of periapical infection. The exposed dentin is vulnerable to microbial invasion because of a defective globular-type calcification as seen in both ground and decalcified sections. The changes are distinctive and pathognomonic, but the effects of therapy (vitamin D) have not yet been ascertained.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications* / Q000473:pathology; D010482:Periapical Abscess / Q000209:etiology; D010508:Periodontal Abscess / Q000209:etiology; D011859:Radiography; D014070:Tooth / Q000473:pathology; D014076:Tooth Diseases / Q000000981:diagnostic imaging / Q000209:etiology*