Modification of biological surface activity of particles.
The hemolytic activity of fibrous asbestos varieties and of fibrous or granular silica dust can be markedly reduced by adsorption of polymers. Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers. A high degree of reduction of the lytic action by comparatively small amounts of the antagonistic polymers can be demonstrated after short exposure to concentrations of 0.1-0.4 mg/ml of appropriate polymers. Inactivation is based on stable adsorption. Repeated washings of inactivated mineral sediments or exposure to elevated temperatures (80-120 degrees C) produced no essential loss of the reduction of lytic potency. In one example, inactivation of chrysotile by sodium alginate, depolymerization by ascorbic acid was also ineffective.
D000327:Adsorption; D000464:Alginates / Q000494:pharmacology; D001194:Asbestos / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006358:Hot Temperature; D011205:Povidone / Q000494:pharmacology; D012822:Silicon Dioxide / Q000494:pharmacology; D013499:Surface Properties; D013997:Time Factors
D000464:Alginates; D001194:Asbestos; D012822:Silicon Dioxide; D002809:Chondroitin Sulfates; D011205:Povidone; D002266:Carboxymethylcellulose Sodium; D001205:Ascorbic Acid