title: Comparison of the effect of alprenolol and propranolol on specific airway conductance in asthmatic subjects.
abstract: Alprenolol did not cause a significant fall in the mean of the specific airway conductance in nine asthmatic subjects who did show a significant fall with propranolol. Thus alprenolol is not contraindicated in asthmatic subjects, though it should be used with caution intravenously, as one subject showed a substantial fall in airway conductance at three minutes which recovered within 30 minutes. Until further studies are completed these results should not be applied to bronchitics with increased airway resistance.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000403:Airway Resistance / Q000187:drug effects*; D000605:Amino Alcohols / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001991:Bronchitis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D006801:Humans; D007275:Injections, Intravenous; D010991:Plethysmography; D011433:Propranolol / Q000627:therapeutic use*; D013565:Sympatholytics / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D013565:Sympatholytics; D011433:Propranolol