title: In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing.
abstract: The in vitro activity of minocycline against 1,028 bacterial strains was determined in parallel in Mueller Hinton Agar and Trypticase Soy Agar. The broad antibacterial effect of minocycline against gram-positive cocci and gram-negative bacilli is confirmed. Minimal inhibitory concentrations for gram-positive bacteria in Mueller Hinton Agar were at least twofold less than in Trypticase Soy Agar. Minimal inhibitory concentrations for gram-negative bacilli in Mueller Hinton Agar were usually fourfold less than in Trypticase Soy Agar.
mesh_terms: D000150:Acinetobacter / Q000187:drug effects; D000362:Agar / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002002:Brucella / Q000187:drug effects; D003470:Culture Media; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006190:Haemophilus / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010325:Pasteurella / Q000187:drug effects; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D003470:Culture Media; D000362:Agar; D013752:Tetracycline