Effects of gamma-hydroxybutyrate on chick behaviour, electrocortical activity and crossed extensor reflexes.
1. Convulsant and anticonvulsant effects of gamma-hydroxybutyrate (GHB) have been studied in chicks.2. When administered alone, GHB produced weak myoclonic seizures accompanied by electrocortical synchrony and spikes.3. GHB was found to protect chicks against leptazol- and picrotoxin-induced seizures. A slight potentiation of strychnine-induced seizures was evident.
D000200:Action Potentials; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D002645:Chickens; D004357:Drug Synergism; D004569:Electroencephalography; D004576:Electromyography; D004594:Electrophysiology; D006885:Hydroxybutyrates / Q000494:pharmacology*; D009207:Myoclonus / Q000139:chemically induced; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010852:Picrotoxin / Q000037:antagonists & inhibitors; D012018:Reflex / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology
D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D006885:Hydroxybutyrates; D010433:Pentylenetetrazole; D010852:Picrotoxin; D013331:Strychnine