Regulation of hepatic lipogenesis by plasma free fatty acids: simultaneous studies on lipoprotein secretion, cholesterol synthesis, ketogenesis and gluconeogenesis.
1. An inverse logarithmic relationship was found between lipogenesis and the concentration of serum free fatty acids perfusing the rat liver. 2. Increased concentrations of serum free fatty acids did not alter cholesterol synthesis, triglyceride secretion or increase gluconeogenesis. 3. No direct relationship was found between ketogenesis and either lipogenesis or gluconeogenesis.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis; D005230:Fatty Acids, Nonesterified / Q000097:blood* / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects; D007657:Ketone Bodies / Q000096:biosynthesis; D008055:Lipids / Q000096:biosynthesis*; D008074:Lipoproteins / Q000096:biosynthesis; D008079:Lipoproteins, VLDL / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007657:Ketone Bodies; D008055:Lipids; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol