Leukemia virus activation in chronic allogeneic disease.
Young adult (BALB/c x A/J)F(1) hybrid mice have no detectable leukemia viruses. When inoculated with parental BALB/c spleen lymphoid cells, also free of detectable virus, leukemia viruses rapidly become activated in the injected host. Because of similarities between such graft-induced allogeneic disease and spontaneous autoimmunity, it is proposed that autoimmune reactions may activate latent viruses.
D000818:Animals; D001327:Autoimmune Diseases / Q000382:microbiology; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D006087:Graft vs Host Reaction; D009052:Leukemia Virus, Murine / Q000472:pathogenicity*; D007942:Leukemia, Experimental / Q000209:etiology; D051379:Mice; D001357:Sarcoma, Avian / Q000382:microbiology; D013154:Spleen / Q000166:cytology / Q000382:microbiology / Q000637:transplantation*