Activity of selected penicillins in vitro and in experimental bacterial infections in mice.
The minimal inhibitory concentration and the 50% mouse protective dose for five key penicillins are presented. Such data provide a useful guide in evaluating the activity of new penicillins, in comparison with those already commercially available, and establishes the amounts of antibiotic necessary to obtain a PD(50) for several experimental model infections in mice.
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D003023:Cloxacillin / Q000494:pharmacology*; D004009:Dicloxacillin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D008712:Methicillin / Q000494:pharmacology*; D051379:Mice; D010068:Oxacillin / Q000494:pharmacology*; D010400:Penicillin G / Q000494:pharmacology*; D010406:Penicillins / Q000627:therapeutic use*; D011511:Proteus / Q000187:drug effects; D011512:Proteus Infections / Q000188:drug therapy; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012482:Salmonella paratyphi A / Q000187:drug effects; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects; D013290:Streptococcal Infections / Q000188:drug therapy; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D010406:Penicillins; D000667:Ampicillin; D004009:Dicloxacillin; D003023:Cloxacillin; D010400:Penicillin G; D008712:Methicillin; D010068:Oxacillin