title: Antifolate resistance and the genetic control of dihydrofolate reductase activity.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis; D004351:Drug Resistance; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects; D007939:Leukemia L1210 / Q000201:enzymology; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009693:Nucleic Acid Hybridization; D010641:Phenotype; D011485:Protein Binding; D011830:Radiation Effects; D013296:Streptococcus pneumoniae / Q000201:enzymology; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014316:Tritium; D014466:Ultraviolet Rays
chemical_list: D004269:DNA, Bacterial; D014316:Tritium; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate