title: Modification of biological surface activity of particles.
abstract: The hemolytic activity of fibrous asbestos varieties and of fibrous or granular silica dust can be markedly reduced by adsorption of polymers. Polyanions exert a specific action on asbestos, particularly chrysotile, whereas silica is inactivated by nonionic polymers. A high degree of reduction of the lytic action by comparatively small amounts of the antagonistic polymers can be demonstrated after short exposure to concentrations of 0.1-0.4 mg/ml of appropriate polymers. Inactivation is based on stable adsorption. Repeated washings of inactivated mineral sediments or exposure to elevated temperatures (80-120 degrees C) produced no essential loss of the reduction of lytic potency. In one example, inactivation of chrysotile by sodium alginate, depolymerization by ascorbic acid was also ineffective.
mesh_terms: D000327:Adsorption; D000464:Alginates / Q000494:pharmacology; D001194:Asbestos / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006358:Hot Temperature; D011205:Povidone / Q000494:pharmacology; D012822:Silicon Dioxide / Q000494:pharmacology; D013499:Surface Properties; D013997:Time Factors
chemical_list: D000464:Alginates; D001194:Asbestos; D012822:Silicon Dioxide; D002809:Chondroitin Sulfates; D011205:Povidone; D002266:Carboxymethylcellulose Sodium; D001205:Ascorbic Acid