title: Synthesis of trimethoprim variations. Replacement of CH 2  by polar groupings.
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D000962:Antimalarials / Q000138:chemical synthesis; D009033:Culicidae; D005493:Folic Acid Antagonists / Q000138:chemical synthesis*; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014295:Trimethoprim / Q000138:chemical synthesis / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D014295:Trimethoprim