Some studies on the biosynthesis of ubiguinone, isoprenoid alcohols, squalene and sterols by marine invertebrates.
The ability of fourteen marine invertebrates to utilize [(14)C]mevalonate for the biosynthesis of isoprenoid compounds was investigated. Several of the animals, in particular crustaceans, bivalve molluscs, a coelenterate and a sponge, were unable to synthesize squalene and sterols, whereas gastropod molluscs, echinoderms, an annelid and a sponge could. Regardless of sterol-synthesizing ability the animals (with the exception of a sponge) always made dolichol and ubiquinone, and thus a specific block in squalene and sterol synthesis was indicated in some animals. Radioactivity accumulated in relatively large amounts in farnesol and geranylgeraniol in those animals incapable of making sterols.
D000438:Alcohols / Q000096:biosynthesis*; D000818:Animals; D000845:Annelida / Q000378:metabolism; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D003063:Cnidaria / Q000378:metabolism; D003445:Crustacea / Q000378:metabolism; D004447:Echinodermata / Q000378:metabolism; D005204:Farnesol / Q000096:biosynthesis; D005233:Fatty Alcohols; D007448:Invertebrates / Q000378:metabolism*; D008386:Marine Biology; D008798:Mevalonic Acid / Q000378:metabolism; D008974:Mollusca / Q000378:metabolism; D011161:Porifera / Q000378:metabolism; D013185:Squalene / Q000096:biosynthesis*; D013261:Sterols / Q000096:biosynthesis*; D013729:Terpenes; D014451:Ubiquinone / Q000096:biosynthesis*
D000438:Alcohols; D002247:Carbon Isotopes; D005233:Fatty Alcohols; D013261:Sterols; D013729:Terpenes; D014451:Ubiquinone; D005204:Farnesol; D013185:Squalene; D008798:Mevalonic Acid