Cardiovascular reactivity in the experimental hypertensive rat.
1. In pithed preparations, deoxycorticosterone (DOCA)/NaCl-induced hypertensive rats showed increased cardiovascular reactivity to injected noradrenaline, DMPP, tyramine, angiotensin and to sympathetic nerve stimulation.2. Pithed, chronic renal hypertensive rats showed similar hyperreactivity to noradrenaline, DMPP and tyramine but responses to sympathetic nerve stimulation were within normal limits.3. In the isolated, Krebs perfused mesentery preparation, vessels obtained from both DOCA/NaCl and renal hypertensive rats showed hyperreactivity to injected noradrenaline. Responses to periarterial nerve stimulation were also markedly increased in preparations from DOCA/NaCl hypertensive rats, while preparations from renal hypertensive rats showed this effect only at higher rates of stimulation (12 and 25 Hz).
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002818:Cordotomy; D003345:Corticosterone; D004558:Electric Stimulation; D005730:Ganglionic Blockers / Q000494:pharmacology; D006973:Hypertension / Q000503:physiopathology*; D006977:Hypertension, Renal / Q000139:chemically induced; D008297:Male; D008643:Mesentery / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D051381:Rats; D012965:Sodium Chloride; D013564:Sympathetic Nervous System / Q000502:physiology; D014439:Tyramine / Q000494:pharmacology
D005730:Ganglionic Blockers; D010879:Piperazines; D000804:Angiotensin II; D012965:Sodium Chloride; D003345:Corticosterone; D009638:Norepinephrine; D014439:Tyramine