Cardio-selective beta-adrenoceptor blockade and the coronary circulation.
After blockade of myocardial, but not coronary vascular beta-adrenoceptors by practolol, cardiac sympathetic stimulation or exogenously administered noradrenaline gave rise to coronary vasoconstriction, possibly due to stimulation of coronary alpha-adrenoceptors.
D000083:Acetanilides / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D003250:Constriction; D003331:Coronary Vessels / Q000187:drug effects*
D000083:Acetanilides; D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols