title: 1-Isopropylamino-3-(4-indanoxy)-2-propanol HC1: a potent beta-adrenoreceptor antagonist.
abstract: 1. The beta-adrenoceptor blocking activity of 1-isopropylamino-3-(4-indanoxy)-2-propanol HCl (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea-pig tracheal strip.2. USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 mug/kg and higher. On the basis of comparative pA(2) values, USVC 6524 is approximately 10 times more potent as a beta-adrenoceptor antagonist than propranolol.3. Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong beta-adrenoceptor blockade.4. USVC 6524 also blocked beta-adrenoceptors in the isolated rat uterus and guinea-pig tracheal spiral strip.
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007192:Indenes / Q000494:pharmacology; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D010208:Papaverine / Q000037:antagonists & inhibitors; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D007192:Indenes; D013565:Sympatholytics; D010208:Papaverine; D007545:Isoproterenol