Quantitative histological distribution of serotonin in the rat stomach.
The quantitative histological distributions of serotonin in the body of the glandular stomach of the fed, fasted, and adrenocorticotrophin [ACTH]-injected rat were established. A tendency to greater serotonin concentrations in the epithelial cell region was found in both the fed and ACTH-treated (10 mg of ACTH in 1 ml of saline, intraperitoneally, 1 hr before killing) states. An elevated concentration observed in the submucosal zone of the fed and fasted animals was shifted to the chief cell zone following the ACTH treatment of the fed rats. This treatment was not given to the fasted animals. Relatively low concentrations were seen in the parietal and mucous neck cell region, in the chief cell zone except for the ACTH influence, and in the muscle. The higher concentration of serotonin in the submucosa may be related to increased innervation and numbers of mast cells, the greater concentration in the epithelial area to mast cell number, and the presence of material on the surface of the mucosa. The latter might also account for the greater concentration in the epithelial zone of the fed rats compared with the fasted rats. Clear differences are apparent in the distribution of serotonin reported in this communication and of histamine reported earlier.
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D005753:Gastric Mucosa / Q000032:analysis / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013270:Stomach / Q000032:analysis* / Q000187:drug effects
D012701:Serotonin; D000324:Adrenocorticotropic Hormone