Stimulant action of tetraethylammonium on the peristaltic reflex of the guinea-pig isolated ileum.
1. Tetraethylammonium (TEA) in concentrations below 0.5 mg/ml. depressed or blocked the peristaltic reflex of the guinea-pig isolated ileum: in concentrations above 0.5 mg/ml. it caused a contraction of the longitudinal muscle and restored the peristaltic reflex previously blocked by the lower concentrations.2. The peristaltic reflex, when blocked by ganglion-blocking agents, morphine and morphine-like agents, 5-hydroxytryptamine, catecholamines or atropine, was restored by high concentrations of TEA.3. The possible mechanisms of these effects are discussed.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002395:Catecholamines / Q000494:pharmacology; D003864:Depression, Chemical; D005730:Ganglionic Blockers / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D009020:Morphine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
D002395:Catecholamines; D005730:Ganglionic Blockers; D013757:Tetraethylammonium Compounds; D012701:Serotonin; D009020:Morphine; D001285:Atropine