Immunochemical studies on the capsular polysaccharide of pneumococcal type IX.
1. In addition to the previously identified components, d-glucose, N-acetyl-d-glucosamine and d-glucuronic acid, the immunologically specific capsular polysaccharide of pneumococcal type IX (polysaccharide S IX) is now found to contain mannosamine and galactosamine, probably as their N-acetyl derivatives. 2. Partial hydrolysis yields a complex mixture of oligosaccharides, several of which have been separated. 3. One of these is alpha-d-glucuronopyranosyl-(1-->3)-d-glucose. It is an inhibitor of the precipitation of antipneumococcal type IX serum by polysaccharide S IX. 4. Two others, d-glucuronopyranosyl-(1-->3)-d-glucosamine and d-glucuronopyranosyl-(1-->3)-d-galactosamine have been identified and a trisaccharide and pentasaccharide partially characterized.
D002852:Chromatography, Ion Exchange; D005688:Galactosamine / Q000032:analysis; D006595:Hexosamines / Q000032:analysis; D006868:Hydrolysis; D007106:Immune Sera; D008358:Mannose / Q000032:analysis; D009844:Oligosaccharides / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D013296:Streptococcus pneumoniae / Q000032:analysis*
D006595:Hexosamines; D007106:Immune Sera; D009844:Oligosaccharides; D011135:Polysaccharides, Bacterial; D005688:Galactosamine; D008358:Mannose