Cyclic adenosine monophosphate phosphodiesterase in brain: effect on anxiety.
Drugs that reduce anxiety may be mediated by cyclic adenosine monophosphate in the brain because (i) potent anxiety-reducing drugs are also potent inhibitors of brain phosphodiesterase activity; (ii) dibutyryl cyclic adenosine monophosphate has the ability to reduce anxiety; (iii) the methylxanthines show significant anxiety-reducing effects; (iv) theophylline and chlordiazepoxide produce additive anxiety-reducing activity; and (v) there is a significant correlation between the anxiety-reducing property of drugs and their ability to inhibit phosphodiesterase activity in the brain.
D000818:Animals; D001007:Anxiety / Q000201:enzymology*; D001463:Barbiturates / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D000242:Cyclic AMP / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D006801:Humans; D010726:Phosphodiesterase Inhibitors; D010727:Phosphoric Diester Hydrolases / Q000032:analysis; D010744:Phosphoric Monoester Hydrolases / Q000032:analysis*; D011678:Punishment; D051381:Rats; D013805:Theobromine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D014149:Tranquilizing Agents / Q000494:pharmacology*
D001463:Barbiturates; D000697:Central Nervous System Stimulants; D010726:Phosphodiesterase Inhibitors; D014149:Tranquilizing Agents; D002110:Caffeine; D002707:Chlordiazepoxide; D013806:Theophylline; D000242:Cyclic AMP; D010744:Phosphoric Monoester Hydrolases; D010727:Phosphoric Diester Hydrolases; D013805:Theobromine; D003975:Diazepam