title: Effect of chronic administration of nicotine on the concentrations of adrenal enzymes involved in the synthesis and metabolism of adrenaline.
abstract: Chronic administration of nicotine caused an increase in tyrosine hydroxylase and catecholamine concentrations in rat adrenals, but failed to affect adrenal monoamine oxidase, catechol-O-methyl transferase or phenylethanol-amine N-methyl transferase activities.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000032:analysis; D004837:Epinephrine / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D009538:Nicotine / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D014166:Transferases / Q000032:analysis; D014316:Tritium; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
chemical_list: D002395:Catecholamines; D014316:Tritium; D009538:Nicotine; D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D014166:Transferases; D004837:Epinephrine