Tumorigenic effect of fibrous dusts in experimental animals.
Fibrous dusts (chrysotile, glass fibers, nemalite, palygorscite, and gypsum) and granular dusts (actinolite, biotite, hematite, pectolite, sanidine, and talcum) were injected intraperitoneally into rats. The fibrous dusts (other than gypsum) resulted in a high incidence of mesothelioma (30 - 67%). Gypsum produced only 5% and granular dusts none at all. It is suggested that the fibrous shape leads to a high multiplication rate of cells and predisposes to tumor formation. Fibrosis, in the other hand, does not so predispose. Milled chrysotile with 99.8% fibers than 5 mum in length are carcinogenic in our experience. The carcinogenicity of glass fibers in our experiments may have significance for occupational situations.
D000008:Abdominal Neoplasms / Q000209:etiology*; D000818:Animals; D001194:Asbestos / Q000009:adverse effects; D002118:Calcium / Q000009:adverse effects; D004391:Dust; D005898:Glass; D007274:Injections, Intraperitoneal; D008654:Mesothelioma / Q000209:etiology*; D051381:Rats; D012822:Silicon Dioxide / Q000009:adverse effects; D013431:Sulfates; D013627:Talc / Q000009:adverse effects
D004391:Dust; D013431:Sulfates; D001194:Asbestos; D013627:Talc; D012822:Silicon Dioxide; D002118:Calcium