Cellular metabolism in genetic transformation of pneumococci: requirement for protein synthesis during induction of competence.
Metabolic inhibitors have differential effects on various phases of genetic transformation in pneumococci. Evidence is presented suggesting that, in addition to the competence factor, another specific protein or class of proteins is essential for the development of cellular "competence." The precise role of this protein(s) in genetic transformation is not known, but it seems essential for some function subsequent to the interaction of competence factor and cells.
D000596:Amino Acids / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002247:Carbon Isotopes; D002701:Chloramphenicol / Q000494:pharmacology; D003470:Culture Media; D004269:DNA, Bacterial / Q000096:biosynthesis; D003864:Depression, Chemical; D005467:Floxuridine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007461:Iodoacetates / Q000494:pharmacology; D046911:Macromolecular Substances / Q000378:metabolism*; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D011691:Puromycin / Q000494:pharmacology; D012329:RNA, Bacterial / Q000096:biosynthesis; D012293:Rifampin / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000378:metabolism*; D013936:Thymidine / Q000494:pharmacology; D014170:Transformation, Genetic / Q000187:drug effects; D014498:Uracil / Q000494:pharmacology
D000596:Amino Acids; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003470:Culture Media; D004269:DNA, Bacterial; D007461:Iodoacetates; D046911:Macromolecular Substances; D012329:RNA, Bacterial; D005467:Floxuridine; D010649:Phenylalanine; D011691:Puromycin; D014498:Uracil; D002701:Chloramphenicol; D005947:Glucose; D013936:Thymidine; D012293:Rifampin