Rapid immunological induction of murine lymphomas: evidence for a viral etiology.
A graft-versus-host reaction induced in (SJL/J x C57BL/1)F(1) hybrid mice by injection of SJL/J spleen cells resulted in 100 percent incidence of tumors at 40 days. Transplantation studies revealed that the tumors were antigenically C57BL/1. Since both SJL/J and C57BL/1 mice carry tumorigenic virus, the evidence suggests a viral etiology.
D000818:Animals; D000956:Antigens, Viral; D005260:Female; D005838:Genotype; D006087:Graft vs Host Reaction; D006824:Hybridization, Genetic; D008223:Lymphoma / Q000209:etiology* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D009368:Neoplasm Transplantation; D009858:Oncogenic Viruses / Q000472:pathogenicity*; D009929:Organ Size; D010227:Parabiosis; D011830:Radiation Effects; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D014181:Transplantation Immunology
D000956:Antigens, Viral