Calcium: is it required for transmitter secretion?
Ethanol multiplies miniature end-plate potential frequency independently of calcium ion concentrations and also multiplies calcium-dependent depolarization-evoked quantal release, to the same extent. This result implies a final common pathway, requiring little or no calcium, for both kinds of transmitter secretion. Chlorpromazine and hypertonicity act similarly to ethanol, but also depress depolarization-secretion coupling.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002614:Chelating Agents / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003964:Diaphragm; D004492:Edetic Acid / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D006982:Hypertonic Solutions / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D051379:Mice; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D013268:Stimulation, Chemical; D013395:Sucrose
D002614:Chelating Agents; D006982:Hypertonic Solutions; D018377:Neurotransmitter Agents; D000431:Ethanol; D013395:Sucrose; D004492:Edetic Acid; D002118:Calcium; D002746:Chlorpromazine