In vitro effects of some chemotherapeutic agents on mycobacteria.
Examination of the bactericidal and bacteriostatic effects of nine antibiotics on atypical mycobacteria revealed that streptovaricin complex and streptovaricin C exerted bactericidal effects on several strains in concentrations lower than 1.0 mug/ml. An exposure to the drug for 48 hr at 37 C was necessary to effect a complete inactivation of more than 99.9% of the exposed microorganisms. The appearance of strepto-varicin-resistant mutants was observed. However, these mutants were unstable, and reversion to streptovaricin susceptibility occurred. Celesticetin salicylate, added in a concentration of 100.0 mug/ml to the medium of Olitzki and Gershon inoculated with Mycobacterium leprae, effected a complete change of the uniformly stained mycobacteria to bipolarity, which indicates the devitalization of this microorganism.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D008034:Lincomycin / Q000494:pharmacology; D009161:Mycobacterium / Q000187:drug effects*; D009166:Mycobacterium leprae / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009675:Novobiocin / Q000494:pharmacology; D000198:Spectinomycin / Q000494:pharmacology; D013310:Streptovaricin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013310:Streptovaricin; D009675:Novobiocin; D000198:Spectinomycin; D008034:Lincomycin