Bone marrow transplantation in a patient with drug-induced aplastic anemia.
A 23-year-old woman gravely ill with Pseudomonas septicemia secondary to presumed drug-induced bone marrow aplasia received marrow transplantation from two male HL-A identical sibling donors. She had a successful engraftment with excellent but temporary clinical improvement. Subsequently she succumbed to graft-versus-host disease manifested by Pseudomonas and Candida albicans septicemia, cytomegalovirus pneumonitis, three phases of dermatitis, nausea, vomiting, dysphagia, diarrhea, fever, edema and bone pain, with gradual but complete graft suppression by the 74th day after the transplantation. A second marrow transplant on the 70th day was unsuccessful.
D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000150:complications / Q000628:therapy; D000927:Anticonvulsants / Q000009:adverse effects*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003586:Cytomegalovirus Infections / Q000209:etiology; D003872:Dermatitis / Q000209:etiology; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D006801:Humans; D007165:Immunosuppression Therapy; D007275:Injections, Intravenous; D007959:Lymphocyte Culture Test, Mixed; D008722:Methods; D011247:Pregnancy; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000209:etiology; D014184:Transplantation, Homologous
D000927:Anticonvulsants; D006649:Histocompatibility Antigens; D003520:Cyclophosphamide