The presence of  -adrenoceptors in the guinea-pig seminal vesicle.
1. The preparation of longitudinal smooth muscle strips from guinea-pig seminal vesicles is described.2. Isoprenaline and salbutamol inhibited contractions produced by parasympathomimetic agents.3. The inhibitory action of isoprenaline was blocked by low concentrations of propranolol and butoxamine. It was concluded that beta(2)-adrenoceptors were present in the tissue.4. The inhibitory action of isoprenaline was not apparent when adrenaline, noradrenaline, hypogastric nerve or transmural stimulation were used to contract the tissue.
D000109:Acetylcholine / Q000009:adverse effects; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000605:Amino Alcohols / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D006168:Guinea Pigs; D006873:Hydroquinones / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D012669:Seminal Vesicles / Q000187:drug effects* / Q000294:innervation
D000318:Adrenergic beta-Agonists; D000605:Amino Alcohols; D006873:Hydroquinones; D010627:Phenethylamines; D011437:Propylamines; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D011433:Propranolol; D007545:Isoproterenol; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine