title: Dual consequence of mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae.
mesh_terms: D000963:Antimetabolites / Q000494:pharmacology; D002875:Chromosomes; D003864:Depression, Chemical; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D005796:Genes; D006358:Hot Temperature; D008727:Methotrexate / Q000494:pharmacology; D009154:Mutation; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology*; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D000963:Antimetabolites; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate