Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat.
D000818:Animals; D002498:Centrifugation; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003640:Dealkylation; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D000882:Haplorhini; D006634:Histamine H1 Antagonists / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000032:analysis / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D008961:Models, Structural; D010879:Piperazines / Q000008:administration & dosage / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*; D011506:Proteins / Q000032:analysis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity; D014316:Tritium
D006634:Histamine H1 Antagonists; D010879:Piperazines; D011506:Proteins; D014316:Tritium