Manganese ions and synaptic transmission in the superior cervical ganglion of the cat.
1 In the perfused superior cervical ganglion of the cat manganese ions (2.7 - 4.6 mM) caused a block of synaptic transmission and reduced the output of acetylcholine.2 Calcium ions (8.4-10.5 mM) relieved the synaptic block produced by manganese and partially restored the acetylcholine output.3 The presence of manganese also reduced the sensitivity of ganglion cells to injected acetylcholine.4 Both effects of manganese were completely reversible.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002415:Cats; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000187:drug effects*; D008345:Manganese / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D009541:Nictitating Membrane / Q000187:drug effects; D010477:Perfusion; D010830:Physostigmine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D008345:Manganese; D010830:Physostigmine; D000109:Acetylcholine; D002118:Calcium