DNA uptake during genetic transformation and the growing zone of the cell envelope.
Continuous cellular incorporation of choline molecules is essential for DNA binding to competent pneumococci. The choline molecules are incorporated into the cell surface at the equatorial region of the cocci. As a working hypothesis, it is proposed that DNA molecules enter these bacteria at the growing zone(s) of the cell envelope.
D000605:Amino Alcohols / Q000378:metabolism; D001345:Autoradiography; D001433:Bacteriolysis; D001665:Binding Sites; D002473:Cell Wall / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D003470:Culture Media; D004269:DNA, Bacterial / Q000378:metabolism*; D008854:Microscopy, Electron; D008954:Models, Biological; D011955:Receptors, Drug; D013296:Streptococcus pneumoniae / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D013682:Teichoic Acids / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism; D014170:Transformation, Genetic; D014316:Tritium
D000605:Amino Alcohols; D003470:Culture Media; D004269:DNA, Bacterial; D011955:Receptors, Drug; D013682:Teichoic Acids; D014316:Tritium; D002794:Choline; D013936:Thymidine