Evidence for the presence of  -adrenoceptors in the central thermoregulatory mechanism of rabbits.
1. The effects of intracerebroventricular administration of some alpha- and beta-adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated.2. Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active.3. The noradrenaline response was blocked by alpha-adrenoceptor blocking agents while beta-adrenoceptor antagonists had no effect.4. alpha-Methyl-noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline.5. The possible presence of alpha-adrenoceptors in the central thermoregulatory mechanisms is suggested.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000605:Amino Alcohols / Q000494:pharmacology; D000813:Anilides / Q000494:pharmacology; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002552:Cerebral Ventricles; D003983:Dibenzylchlorethamine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D007267:Injections; D008680:Metaraminol / Q000494:pharmacology; D009578:Nitrobenzenes / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology*; D009647:Normetanephrine / Q000494:pharmacology; D011817:Rabbits; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D013451:Sulfonic Acids / Q000494:pharmacology; D014043:Tolazoline / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D000813:Anilides; D009578:Nitrobenzenes; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D013451:Sulfonic Acids; D009647:Normetanephrine; D003983:Dibenzylchlorethamine; D008680:Metaraminol; D014043:Tolazoline; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine