Metabolism of rotenone in vitro by tissue homogenates from mammals and insects.
Hydroxylation of rotenone in vitro in the enzyme system composed of microsomes and reduced nicotinamide-adenine dinucleotide phosphate, and in living mice and houseflies, yields products tentatively identified as rotenolone I; rotenolone II; 8'-hydroxyrotenone; 6',7'-dihydro-6',7'-dihydroxyrotenone; two rotenolones of each of the last-mentioned two compounds; and uncharacterized polar materials. The toxicity of certain of these rotenoids to mice is of the same order as that of rotenone.
D000005:Abdomen / Q000378:metabolism*; D000818:Animals; D006793:Houseflies / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008861:Microsomes / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D051381:Rats; D012402:Rotenone / Q000378:metabolism*
D012402:Rotenone; D009249:NADP