Potassium ion release and enzyme secretion: adrenergic regulation by alpha- and beta-receptors.
Epinephrine caused amylase secretion and K(+) release in rat parotid slices. Propranolol, which blocks beta-receptors, inhibited amylase secretion; phentolamine, which blocks alpha-receptors, inhibited K(+) release. Since enzyme secretion was associated with fusion of secretory granules to the cell membrane and K(+) release was associated with vacuole formation, it could be shown that both alpha- and beta-receptors are present in the same exocrine cell. The findings appear to exclude cyclic 3',5'-adenosine monophosphate as an intermediate in the alpha-receptor response.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D003593:Cytoplasm; D004837:Epinephrine / Q000494:pharmacology; D008854:Microscopy, Electron; D010306:Parotid Gland / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic; D011955:Receptors, Drug
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D011433:Propranolol; D000681:Amylases; D011188:Potassium; D004837:Epinephrine; D010646:Phentolamine