Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002460:Cell Line / Q000201:enzymology; D002845:Chromatography; D002850:Chromatography, Gel; D004789:Enzyme Activation; D005492:Folic Acid; D005493:Folic Acid Antagonists; D006146:Guanidines / Q000494:pharmacology; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008223:Lymphoma / Q000201:enzymology; D008727:Methotrexate; D051379:Mice; D008815:Mice, Inbred Strains; D009249:NADP; D011189:Potassium Chloride / Q000494:pharmacology; D011489:Protein Denaturation; D011743:Pyrimidines / Q000494:pharmacology; D013154:Spleen / Q000201:enzymology*; D013762:Tetrahydrofolate Dehydrogenase / Q000302:isolation & purification; D014227:Triazines / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
D005493:Folic Acid Antagonists; D006146:Guanidines; D011743:Pyrimidines; D014227:Triazines; D009249:NADP; D011189:Potassium Chloride; D014508:Urea; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate