The type-specific substance from Pneumococcus type 11A(43).
1. The type-specific substance from Pneumococcus type 11A(43) is a polymer containing d-glucose, d-galactose, glycerol, phosphate and O-acetyl in the approximate molecular proportions 2:2:1:1:2. 2. Removal of the O-acetyl groups with ammonia gave a compound no longer active towards type 11A antiserum. 3. Treatment of S.11A with sodium borohydride, followed by hydrolysis with alkali yielded a phosphorus-free polysaccharide, whose structure was studied by methylation and by degradation with periodate. 4. Examination of S.11A and its de-O-acetyl derivative by periodate oxidation led to the partial structure (XI) for the type-specific substance, which thus has several features in common with S.18.
D000641:Ammonia / Q000494:pharmacology; D002854:Chromatography, Paper; D005690:Galactose / Q000032:analysis; D005947:Glucose / Q000032:analysis; D005990:Glycerol / Q000032:analysis; D007106:Immune Sera; D008745:Methylation; D010504:Periodic Acid / Q000494:pharmacology; D010710:Phosphates / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D013045:Species Specificity; D013296:Streptococcus pneumoniae / Q000032:analysis* / Q000276:immunology
D007106:Immune Sera; D010710:Phosphates; D011135:Polysaccharides, Bacterial; D010504:Periodic Acid; D000641:Ammonia; D005947:Glucose; D005990:Glycerol; D005690:Galactose