title: Incorporation of thymidine and amino acids into deoxyribonucleic acid and acid-insoluble cell structures in pneumococcal cultures synchronized for competence to transform.
abstract: Ephrussi-Taylor, Harriett (Western Reserve University, Cleveland, Ohio), and Barbara A. Freed. J. Bacteriol. 87:1211-1215. 1964.-Pneumococcal cultures, in which competence to transform develops in an acute, synchronous fashion toward the end of growth of the cultures, show an arrest in lysine incorporation into trichloroacetic acid-insoluble residues during the competent period. Thymidine incorporation into deoxyribonucleic acid is momentarily halted after the development of maximal competence. It is suggested that competence is associated with a brief arrest of normal cell-wall synthesis.
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D002247:Carbon Isotopes; D002473:Cell Wall / Q000254:growth & development; D004269:DNA, Bacterial / Q000096:biosynthesis*; D005823:Genetics; D008239:Lysine / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000254:growth & development*; D013936:Thymidine / Q000378:metabolism*; D014238:Trichloroacetic Acid
chemical_list: D000596:Amino Acids; D002247:Carbon Isotopes; D004269:DNA, Bacterial; D014238:Trichloroacetic Acid; D008239:Lysine; D013936:Thymidine