Effect of cyclic guanosine 3,5-monophosphate on the synthesis of enzymes sensitive to  caatabolite repression in intact cells of Escherichia coli.
Cyclic guanosine 3',5'-monophosphate inhibits the synthesis of beta-galactosidase and tryptophanase in cultures of Escherichia coli growing in minimal media with glucose or glycerol as the carbon source. Cyclic guanosine 3',5'-monophosphate acts at the transcriptional level in the lac operon, it exerts its action at the promoter site of the operon, and requires the presence of functional cyclic adenosine 3',5'-monophosphate receptor protein.
D002250:Carbon Radioisotopes; D003470:Culture Media; D000242:Cyclic AMP / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology*; D004790:Enzyme Induction; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D005696:Galactosidases / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D005947:Glucose / Q000494:pharmacology; D005990:Glycerol / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008190:Lyases / Q000096:biosynthesis*; D009154:Mutation; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D013268:Stimulation, Chemical; D014368:Tryptophanase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
D002250:Carbon Radioisotopes; D003470:Culture Media; D012333:RNA, Messenger; D000242:Cyclic AMP; D005696:Galactosidases; D008190:Lyases; D014368:Tryptophanase; D007930:Leucine; D006152:Cyclic GMP; D005947:Glucose; D005990:Glycerol