title: A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates.
abstract: GSH added to rat liver homogenates inhibited respiration and increased GSSG formation approximately proportionally to the amount of GSH added; the effect was increased by added magnesium chloride. Added NADPH and citrate decreased GSSG formation and increased respiration; 6.0mm-nicotinamide prevented GSSG formation and increased respiration. There was a negative correlation between GSSG formation and oxygen uptake. It is suggested that the decrease in oxygen uptake is mainly due to GSSG concentration and also that in vivo a GSH-GSSG steady state occurs.
mesh_terms: D000818:Animals; D002951:Citrates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009249:NADP / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D051381:Rats
chemical_list: D002951:Citrates; D009536:Niacinamide; D009249:NADP; D005978:Glutathione; D008274:Magnesium