Structural basis for the inhibition of protein biosynthesis: mode of action of tubulosine.
A structural model for the inhibition of protein biosynthesis was previously formulated on the basis of a topochemical analogy between the ipecac alkaloids and the glutarimide antibiotics. The structure of tubulosine satisfies the requirements of this model. The prediction that such a compound would exhibit amebicidal activity and act by selectively inhibiting the transfer reaction in protein biosynthesis is confirmed.
D000470:Alkaloids / Q000494:pharmacology*; D000563:Amebicides / Q000494:pharmacology*; D000963:Antimetabolites; D002626:Chemistry, Pharmaceutical; D004247:DNA / Q000096:biosynthesis; D004926:Escherichia coli / Q000166:cytology; D006367:HeLa Cells; D006454:Hemoglobins / Q000096:biosynthesis; D066298:In Vitro Techniques; D007486:Ipecac; D007930:Leucine / Q000378:metabolism; D008962:Models, Theoretical; D010649:Phenylalanine / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D012343:RNA, Transfer / Q000378:metabolism; D012156:Reticulocytes / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D012440:Saccharomyces / Q000166:cytology
D000470:Alkaloids; D000563:Amebicides; D000963:Antimetabolites; D006454:Hemoglobins; D010649:Phenylalanine; D012313:RNA; D007486:Ipecac; D004247:DNA; D012343:RNA, Transfer; D007930:Leucine