Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine.
1. Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25-30% after 30 minutes.2. The effect of several receptor blocking drugs on the amphetamine-induced cerebral glycogenolysis was studied.3. DL-Propranolol (0.25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine.4. Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine-induced glycogenolysis.5. D-Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses.6. It is concluded that amphetamine-induced glycogenolysis in the mouse brain may be mediated through a beta-adrenoceptor.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects*; D003913:Dextroamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology; D006003:Glycogen / Q000032:analysis*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D006634:Histamine H1 Antagonists; D013565:Sympatholytics; D010643:Phenoxybenzamine; D001285:Atropine; D006003:Glycogen; D011433:Propranolol; D003913:Dextroamphetamine; D008784:Methysergide; D010646:Phentolamine