Immunologic properties of mouse thymus cells. Identification of T cell functions within a minor, low-density subpopulation.
The functional attributes of minor subpopulations of mouse thymus cells derived by bovine serum albumin density gradient centrifugation, cortisone treatment, or selective depletion by anti-TL or anti-theta treatment have been examined. A subpopulation derived in each fashion contains the cells required to evoke graft-versus-host reactions in neonatal F(1) hybrid recipients and to be stimulated by alloantigens in vitro in one-way mixed lymphocyte cultures and by phytohemagglutinin. The functions of this subpopulation are abrogated by treatment with anti-H-2 plus complement and by high concentrations of anti-theta. A tentative ordering of the various thymus cell subpopulations, on the basis of these and other data, is described.
D000818:Animals; D002462:Cell Membrane / Q000276:immunology; D002499:Centrifugation, Density Gradient; D003165:Complement System Proteins; D003348:Cortisone / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007519:Isoantigens; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D012486:Salmonella typhimurium; D012710:Serum Albumin, Bovine; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D014316:Tritium
D004731:Endotoxins; D006649:Histocompatibility Antigens; D007106:Immune Sera; D007519:Isoantigens; D037102:Lectins; D014316:Tritium; D012710:Serum Albumin, Bovine; D003165:Complement System Proteins; D003348:Cortisone; D013936:Thymidine