The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat.
1. A method for the measurement of anaphylactic bronchoconstriction in the rat is described.2. Dexamethasone inhibited this response in a dose-related manner.3. Disodium cromoglycate antagonized the response. A bell-shaped dose-response curve was obtained with peak activity at 1 mg/kg i.v.4. Meclofenamate was not active when given alone or in combination with dexamethasone.5. Methysergide significantly inhibited the response. Mepyramine, atropine, propranolol and adrenalectomy did not significantly modify the response.6. The relationships of anaphylactic bronchoconstriction in the rat to anaphylactic bronchoconstriction in the guinea-pig and to human asthma are discussed.
D000315:Adrenalectomy; D000707:Anaphylaxis; D000818:Animals; D000941:Antigens; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D003250:Constriction; D004205:Cromolyn Sodium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003907:Dexamethasone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009349:Nematode Infections / Q000276:immunology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014050:Toluene / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D000941:Antigens; D006634:Histamine H1 Antagonists; D062367:ortho-Aminobenzoates; D014050:Toluene; D001285:Atropine; D003907:Dexamethasone; D011433:Propranolol; D004205:Cromolyn Sodium; D008784:Methysergide