Abolition of the nerve-induced responses of the isolated vas deferens of the young rat by agents blocking  -adrenoceptors.
The mechanical responses of isolated fieldstimulated vasa deferentia from rats 3-10 days old were abolished by low doses of drugs blocking alpha-adrenoceptors. In preparations from older animals this effect was absent or there was a potentiation of the responses. The effect of atropine also changed during postnatal development. In the early period a moderate (10-40%) decline of the nerve-induced responses was generally observed, but later even high concentrations of atropine were without effect.
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*; D014649:Vas Deferens / Q000187:drug effects* / Q000254:growth & development / Q000294:innervation
D000317:Adrenergic alpha-Antagonists; D013565:Sympatholytics; D010643:Phenoxybenzamine; D001285:Atropine; D010646:Phentolamine