In vitro antibacterial activity of minocycline and effect of agar medium utilized in its susceptibility testing.
The in vitro activity of minocycline against 1,028 bacterial strains was determined in parallel in Mueller Hinton Agar and Trypticase Soy Agar. The broad antibacterial effect of minocycline against gram-positive cocci and gram-negative bacilli is confirmed. Minimal inhibitory concentrations for gram-positive bacteria in Mueller Hinton Agar were at least twofold less than in Trypticase Soy Agar. Minimal inhibitory concentrations for gram-negative bacilli in Mueller Hinton Agar were usually fourfold less than in Trypticase Soy Agar.
D000150:Acinetobacter / Q000187:drug effects; D000362:Agar / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002002:Brucella / Q000187:drug effects; D003470:Culture Media; D004755:Enterobacteriaceae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006190:Haemophilus / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010325:Pasteurella / Q000187:drug effects; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D012760:Shigella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology*
D003470:Culture Media; D000362:Agar; D013752:Tetracycline