title: Magnesium pemoline: enhancement of brain RNA polymerases.
abstract: The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology; D008774:Methylphenidate / Q000494:pharmacology; D009713:Nucleotidyltransferases; D010080:Oxazoles / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D010389:Pemoline / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014293:Trimethadione / Q000494:pharmacology
chemical_list: D000927:Anticonvulsants; D010080:Oxazoles; D010880:Piperidines; D008774:Methylphenidate; D008694:Methamphetamine; D012313:RNA; D010389:Pemoline; D010293:Pargyline; D009713:Nucleotidyltransferases; D008274:Magnesium; D007099:Imipramine; D014293:Trimethadione