Specificity of anti-nucleoside antibodies.
The method of conjugation of a nucleoside or related compound to a carrier protein may have a significant effect on the specificity of the antibodies elicited. It is demonstrated, by means of the membrane-filtration assay, that anti-isopentenyladenosine antibodies produced by the ;periodate procedure' are much more reactive with the periodate-oxidized form of the nucleoside than with the parent compound. In addition, the simplicity and specificity of the assay used suggests its use as a sensitive radioimmunoassay for this multifunctional nucleoside.
D000241:Adenosine; D000249:Adenosine Monophosphate; D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D002417:Cattle; D006150:Guanine Nucleotides; D006241:Haptens; D007106:Immune Sera; D005779:Immunodiffusion; D009705:Nucleosides; D010504:Periodic Acid; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay; D012710:Serum Albumin, Bovine; D014316:Tritium
D000906:Antibodies; D006150:Guanine Nucleotides; D006241:Haptens; D007106:Immune Sera; D009705:Nucleosides; D014316:Tritium; D010504:Periodic Acid; D012710:Serum Albumin, Bovine; D000249:Adenosine Monophosphate; D000241:Adenosine