Failure of cycloheximide to induce tyrosine transaminase in the anesthetized rat.
It was recently reported that cycloheximide, an inhibitor of protein synthesis, induces tyrosine transaminase in the liver of adrenalectomized rats. We have been unable to confirm this effect in the anesthetized animal and our data show that cycloheximide inhibits the induction caused by hydrocortisone in adrenalectomized rats or by stress in intact rats.
D000315:Adrenalectomy; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects*; D005809:Genes, Regulator; D006854:Hydrocortisone / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D013053:Spectrophotometry; D013312:Stress, Physiological / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D003513:Cycloheximide; D014444:Tyrosine Transaminase; D006854:Hydrocortisone