Amino acid oxidase in leukocytes: evidence against a major role in phagocytosis.
The addition of either d- or l-amino acids fails to increase hexose monophosphate shunt activity of resting or phagocytizing neutrophils. This is presumptive evidence against a major role for amino acid oxidase in the bactericidal activity of the cell.
D000409:Alanine / Q000378:metabolism; D000594:Amino Acid Oxidoreductases / Q000032:analysis*; D001205:Ascorbic Acid / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002247:Carbon Isotopes; D003605:D-Amino-Acid Oxidase / Q000032:analysis; D005947:Glucose / Q000378:metabolism; D006600:Hexosephosphates / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D009504:Neutrophils / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010587:Phagocytosis; D013912:Threonine / Q000378:metabolism
D002247:Carbon Isotopes; D006600:Hexosephosphates; D002245:Carbon Dioxide; D013912:Threonine; D006861:Hydrogen Peroxide; D000594:Amino Acid Oxidoreductases; D003605:D-Amino-Acid Oxidase; D005947:Glucose; D000409:Alanine; D001205:Ascorbic Acid