Cyclic adenosine 3',5'-monophosphate during glucose repression in the rat liver.
Intragastric administration of glucose inhibits the induction of serine dehydratase and tyrosine aminotransferase by glucagon in rat liver, but has no effect on the increase in hepatic adenosine 3',5'-monophosphate resulting from administration of glucagon. Thus, glucose repression in mammalian liver, unlike catabolite repression in microorganisms, appears to operate independently of the amounts of cyclic nucleotide in the cells.
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D005934:Glucagon / Q000037:antagonists & inhibitors; D005947:Glucose / Q000494:pharmacology*; D012695:L-Serine Dehydratase / Q000096:biosynthesis; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D014444:Tyrosine Transaminase / Q000096:biosynthesis
D005934:Glucagon; D000242:Cyclic AMP; D014444:Tyrosine Transaminase; D012695:L-Serine Dehydratase; D005947:Glucose