Growth inhibition of tumour implants by associated surface active agents.
Whereas dilute solutions of surface active agents modify the properties of cell membranes, particularly in relation to their electrical behaviour, moderate and strong solutions provoke more serious structural damage of the membrane, leading to an increase of its permeability and, finally, to cytolysis. These phenomena have inspired some authors to apply detergents as possible cancer chemotherapeuticals so far, however, with only poor results. The disintegrating effect of tumour emboli into single cells by certain detergents, and the ingenious discovery that the mutual adhesiveness between cancer cells is much less than between normal cells, have led the present authors to investigate the action of some biological surface active agents, alone as well as in some of their associations on the "take" of Yoshida sarcoma implants. Certain associations showed, in contradistinction to the separately applied components, surprisingly favourable activity. It could be established that a correlation actually exists between inhibitory effect and surface activity.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002784:Cholesterol / Q000627:therapeutic use; D004357:Drug Synergism; D005934:Glucagon / Q000627:therapeutic use; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D007093:Imidazoles / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009368:Neoplasm Transplantation; D010743:Phospholipids / Q000627:therapeutic use; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy*; D013500:Surface Tension; D013501:Surface-Active Agents / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D007093:Imidazoles; D007328:Insulin; D010743:Phospholipids; D013501:Surface-Active Agents; D005934:Glucagon; D002784:Cholesterol