A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.
D000818:Animals; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000494:pharmacology; D005958:Glucosephosphates / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D010088:Oxidoreductases / Q000032:analysis; D010634:Phenobarbital / Q000494:pharmacology; D010879:Piperazines / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014316:Tritium
D005958:Glucosephosphates; D006634:Histamine H1 Antagonists; D010879:Piperazines; D011506:Proteins; D009243:NAD; D014316:Tritium; D009249:NADP; D008748:Methylcholanthrene; D010088:Oxidoreductases; D005954:Glucosephosphate Dehydrogenase; D010634:Phenobarbital