Effect of chronic administration of nicotine on the concentrations of adrenal enzymes involved in the synthesis and metabolism of adrenaline.
Chronic administration of nicotine caused an increase in tyrosine hydroxylase and catecholamine concentrations in rat adrenals, but failed to affect adrenal monoamine oxidase, catechol-O-methyl transferase or phenylethanol-amine N-methyl transferase activities.
D000311:Adrenal Glands / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D002395:Catecholamines / Q000032:analysis; D004837:Epinephrine / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000032:analysis; D009538:Nicotine / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D014166:Transferases / Q000032:analysis; D014316:Tritium; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D002395:Catecholamines; D014316:Tritium; D009538:Nicotine; D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D014166:Transferases; D004837:Epinephrine