Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme.
The hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme has been investigated by using an automated ninhydrin technique. The results show an inverse relationship of hydrolysis rate with size and charge of the peptide, which parallels the inactivation in the pulmonary circulation and offers an explanation for the selectivity of metabolism of these kinins by the lungs.
D000595:Amino Acid Sequence; D000804:Angiotensin II; D000818:Animals; D001920:Bradykinin / Q000378:metabolism*; D006868:Hydrolysis; D008168:Lung / Q000201:enzymology; D009555:Ninhydrin; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011652:Pulmonary Circulation; D013552:Swine
D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D009555:Ninhydrin; D001920:Bradykinin