Ethanol oxidation by hepatic microsomes: adaptive increase after ethanol feeding.
Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.
D000079:Acetaldehyde / Q000378:metabolism; D000222:Adaptation, Physiological; D000429:Alcohol Oxidoreductases; D000818:Animals; D000431:Ethanol / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats
D000431:Ethanol; D009249:NADP; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D000079:Acetaldehyde