Comparison of two oral selective beta2-adrenergic stimulant drugs in bronchial asthma.
The effect of two oral selective beta(2)-stimulant drugs, salbutamol and terbutaline, on spirometry, arterial blood-gas tensions, pulse, and blood pressure was compared with placebo in a double-blind controlled trial in 12 asthmatic patients. Both drugs increased to forced vital capacity and the forced expiratory volume in 1 second equally for up to five hours, the maximal effect occurring at two to four hours. There was no significant change in arterial blood-gas tensions but both drugs increased pulse rate slightly. Tremor was the most common side effect. Terbutaline seems to be an effective alternative to salbutamol.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D000605:Amino Alcohols / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002082:Butylamines / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010919:Placebos; D012118:Resorcinols / Q000627:therapeutic use; D013147:Spirometry; D014202:Tremor / Q000139:chemically induced
D000318:Adrenergic beta-Agonists; D000605:Amino Alcohols; D001993:Bronchodilator Agents; D002082:Butylamines; D010919:Placebos; D012118:Resorcinols; D002245:Carbon Dioxide; D000431:Ethanol; D010100:Oxygen