5-Hydroxytryptamine metabolism in rat brain and liver homogenates.
1. The metabolism of 5-hydroxyindoleacetaldehyde derived from 5-hydroxytryptamine incubated with tissue homogenates was studied as an indicator of aldehyde dehydrogenase and alcohol dehydrogenase activities.2. In liver and brain from rats, there were indications of the presence of one or more aldehyde dehydrogenases which were stimulated by NAD(+) to a greater extent than by NADP(+).3. In liver from rats, there were indications of the presence of one or more alcohol dehydrogenases, which were stimulated by NADH to a greater extent than by NADPH.4. In brain from rats, there were indications of the presence of one or more alcohol dehydrogenases which were stimulated by NADPH to a greater extent than by NADH.
D000429:Alcohol Oxidoreductases; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000096:biosynthesis; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D009243:NAD; D009249:NADP; D010088:Oxidoreductases; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical
D009243:NAD; D012701:Serotonin; D009249:NADP; D006897:Hydroxyindoleacetic Acid; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases