Simplified method for determining acetylator phenotype.
A chemical method has been developed for estimating the acetylator phenotype without the use of special equipment. One urine specimen taken after ingestion of sulphadimidine, sulphapyridine, or sulphasalazine is required. The acetylator phenotype was assessed correctly in 150 urine specimens from 100 healthy subjects. Between 15 and 25 specimens can be determined hourly. Urine specimens for the test can be stored for two weeks at 37 degrees C without any loss of drugs or their metabolites.
D000085:Acetates / Q000378:metabolism*; D000215:Acylation; D003124:Colorimetry; D006801:Humans; D008722:Methods; D010641:Phenotype; D011309:Preservation, Biological; D013048:Specimen Handling; D013418:Sulfamethazine / Q000378:metabolism; D012460:Sulfasalazine / Q000378:metabolism; D013449:Sulfonamides / Q000378:metabolism*; D013997:Time Factors; D014556:Urine
D000085:Acetates; D013449:Sulfonamides; D012460:Sulfasalazine; D013418:Sulfamethazine