Bretylium potentiation of the contractor responses of isolated rabbit aortic strips to potassium and tyramine.
1. Pretreatment of rabbit aortic strips with bretylium potentiated the contractor response to potassium and tyramine but not to noradrenaline. On the other hand, such pretreatment inhibited the response to nicotine.2. Even in reserpinized or cold stored aortic strips, pretreatment with bretylium enhanced the contractor response to potassium and tyramine.3. Pretreatment of fresh, reserpinized, or cold stored aortic strips with pheniprazine potentiated the contractor response to potassium and tyramine.4. Pretreatment of aortic strips with bretylium or pheniprazine did not potentiate the response to 5-hydroxytryptamine (5-HT).5. The results indicate that both bretylium and pheniprazine potentiate the action of tyramine and potassium, not by presynaptic mechanisms, but by postsynaptic action, causing an increase in the sensitivity of the effector cells to the stimulants.
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001949:Bretylium Compounds / Q000494:pharmacology*; D004357:Drug Synergism; D006834:Hydrazines / Q000494:pharmacology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009538:Nicotine / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D011817:Rabbits; D011955:Receptors, Drug; D012701:Serotonin / Q000494:pharmacology; D013748:Tetracaine / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology*
D001949:Bretylium Compounds; D006834:Hydrazines; D011955:Receptors, Drug; D013748:Tetracaine; D012701:Serotonin; D009538:Nicotine; D011188:Potassium; D009638:Norepinephrine; D014439:Tyramine