Inhibition by antihistamines of the vascular permeability increase induced by bradykinin.
1. Mepyramine and triprolidine hydrochloride have a marked inhibitory effect on the local increase of vascular permeability induced by bradykinin.2. The anti-bradykinin effect of both antihistamines was species dependent, being evident in rabbits, rats and mice but not in guinea-pigs.
D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D002199:Capillary Permeability / Q000187:drug effects*; D002744:Chlorpheniramine / Q000494:pharmacology; D004396:Coloring Agents; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014311:Triprolidine / Q000494:pharmacology
D004396:Coloring Agents; D006634:Histamine H1 Antagonists; D014311:Triprolidine; D002744:Chlorpheniramine; D006632:Histamine; D001920:Bradykinin