Magnesium pemoline: enhancement of brain RNA polymerases.
The stimulation by magnesium pemoline of systems that synthesize brain nucleic acid was studied in vivo and in vitro. There are differential effects between true RNA polymerase and pseudo-RNA polymerase. The selective stimulation of true RNA polymerase by magnesium pemoline was not observed with stimulants of the central nervous system and psychotropic agents.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology*; D008694:Methamphetamine / Q000494:pharmacology; D008774:Methylphenidate / Q000494:pharmacology; D009713:Nucleotidyltransferases; D010080:Oxazoles / Q000494:pharmacology*; D010293:Pargyline / Q000494:pharmacology; D010389:Pemoline / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D014293:Trimethadione / Q000494:pharmacology
D000927:Anticonvulsants; D010080:Oxazoles; D010880:Piperidines; D008774:Methylphenidate; D008694:Methamphetamine; D012313:RNA; D010389:Pemoline; D010293:Pargyline; D009713:Nucleotidyltransferases; D008274:Magnesium; D007099:Imipramine; D014293:Trimethadione