Serum inhibition of gingival collagenase.
Collagenases derived from bovine and human gingiva are inhibited effectively by serum. In bovine and human serum fractionated by gel chromatography, alpha2-macroglobulin is the only significant inhibitor of gingival collagenase. alpha11-Antitrypsin inhibited collagenase only in very high concentration and was several hundred-fold less effective than alpha2-macroglobulin. Inhibition of gingival collagenase with alpha2-macroglobulin is accompanied by the formation of an enzyme-inhibitor complex, which has retained no collagenolytic activity.
D000818:Animals; D002417:Cattle; D005881:Gingiva / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D008259:Macroglobulins / Q000378:metabolism; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors* / Q000097:blood; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D008259:Macroglobulins; D000515:alpha 1-Antitrypsin; D003012:Microbial Collagenase