Turnover rate of brain 5-hydroxytryptamine increased by D-amphetamine.
1. Administration of two doses of amphetamine HCl (5 mg/kg intraperitoneally) 45 min apart raised body temperature of rats by an average of 3.4 degrees C and increased the turnover rate of brain 5-hydroxytryptamine (5-HT) by almost one-half.2. Both effects were blocked by exposure to 4 degrees C or by pretreatment with the beta-blocker Kö 592 (1-(2-methylphenoxy)-3-isopropylamine-2-propanol), but not by the administration of the ganglionic blocker chlorisondamine combined with atropine.3. Since it has previously been shown that hyperthermia per se increases the turnover rate of brain 5-HT, and that amphetamine does not directly affect the uptake and release of 5-HT in brain slices, it is concluded that the amphetamine-induced increase in 5-HT turnover may be secondary to the rise in temperature produced by the drug.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000605:Amino Alcohols / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002714:Chlorisondamine / Q000494:pharmacology; D003080:Cold Temperature; D003913:Dextroamphetamine / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D001285:Atropine; D002714:Chlorisondamine; D003913:Dextroamphetamine