Graft versus leukemia: quantification of adoptive immunotherapy in murine leukemia.
Quantification of the antileukemic reactivity of transplanted immunocompetent cells from various allogeneic donors was achieved against a long-passage lymphocytic leukemia of AKR mice. Adoptive immunotherapy was the exclusive antileukemic treatment. Cells from DBA/2 donors exhibited maximal antileukemic effect, inactivating up to an estimated 10(7) leukemia cells. The cellular events were interpreted by using a theoretical cytokinetic construct.
D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation; D007111:Immunity, Cellular; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D007167:Immunotherapy; D007942:Leukemia, Experimental; D007945:Leukemia, Lymphoid / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011828:Radiation Chimera; D013154:Spleen / Q000166:cytology / Q000276:immunology; D014184:Transplantation, Homologous