In vitro activation of isophosphamide (NSC-109724), a new oxazaphosphorine, by rat liver microsomes.
D000477:Alkylating Agents / Q000494:pharmacology; D000478:Alkylation; D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D003498:Cyclic P-Oxides / Q000378:metabolism*; D003520:Cyclophosphamide / Q000378:metabolism; D004247:DNA / Q000032:analysis; D003640:Dealkylation; D004789:Enzyme Activation / Q000187:drug effects; D005021:Ethylamines / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000032:analysis; D008297:Male; D008862:Microsomes, Liver / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D009019:Morphinans / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010078:Oxazines / Q000378:metabolism*; D010088:Oxidoreductases / Q000032:analysis; D010634:Phenobarbital / Q000494:pharmacology; D010753:Phosphoranes / Q000032:analysis; D011335:Proadifen / Q000494:pharmacology; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats
D000477:Alkylating Agents; D000814:Aniline Compounds; D003498:Cyclic P-Oxides; D005021:Ethylamines; D009019:Morphinans; D010078:Oxazines; D010753:Phosphoranes; D011506:Proteins; D000632:Aminopyrine; D009249:NADP; D012313:RNA; D003520:Cyclophosphamide; D004247:DNA; D011335:Proadifen; D010088:Oxidoreductases; D010634:Phenobarbital