title: A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism; D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D006224:Cricetinae; D004058:Diffusion; D004798:Enzymes / Q000378:metabolism; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006207:Half-Life; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008107:Liver Diseases / Q000378:metabolism; D008660:Metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008962:Models, Theoretical; D009336:Necrosis / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D012039:Regional Blood Flow; D013431:Sulfates / Q000378:metabolism; D014116:Toxicology
chemical_list: D001555:Benzene Derivatives; D004798:Enzymes; D005965:Glucuronates; D013431:Sulfates; D000082:Acetaminophen; D008748:Methylcholanthrene; D011335:Proadifen; D005978:Glutathione; D010634:Phenobarbital