Influence of DEAE-dextran, polybrene, dextran and dextran sulphate on spontaneous leukaemia development in AKR mice and virus induced leukaemia in BALB-c mice.
AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development.Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use* / Q000633:toxicity; D004586:Electrophoresis; D006842:Hydrocarbons, Brominated / Q000627:therapeutic use; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D007945:Leukemia, Lymphoid / Q000517:prevention & control*; D007962:Leukocytes; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D011073:Polyamines / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use; D011925:Rauscher Virus
D003911:Dextrans; D006842:Hydrocarbons, Brominated; D011073:Polyamines; D011108:Polymers