Characterization of the coronary vascular  -adrenoceptor in the pig.
The beta-adrenoceptor in pig coronary vascular smooth muscle has been characterized by the use of a selective agonist, salbutamol and a selective antagonist, practolol. In coronary artery strips contracted with KCI, salbutamol had only marginal relaxant activity and was a partial agonist compared with isoprenaline. Practolol had relatively high antagonist potency against isoprenaline (pA(2) 6.59). It is concluded that the pig coronary vascular,beta-adrenoceptor is of the beta(1)-type.
D000083:Acetanilides / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D000605:Amino Alcohols / Q000494:pharmacology; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D009130:Muscle, Smooth / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D011941:Receptors, Adrenergic; D013552:Swine
D000083:Acetanilides; D000319:Adrenergic beta-Antagonists; D000605:Amino Alcohols; D001993:Bronchodilator Agents; D011941:Receptors, Adrenergic; D011189:Potassium Chloride; D007545:Isoproterenol