Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex.
The influence of the major mouse histocompatibility gene complex (H-2) on the response of mice to Friend leukemia virus was studied in F(1) congenic mice differing only at genes within the H-2 complex. F(1) mice which were H-2(b/b) had a high incidence of recovery from splenomegaly compared to H-2(b/d) or H-2(b/a) mice. In mice with recombinations within the H-2 complex a gene (designated RFV-1), responsible for the Friend virus recovery effect, was found to map near or within the D region of serologically detectable transplantation antigens. Because the incidence of recovery was much higher in F(1)H-2(b/b) mice than in parental H-2(b/b) mice, other non-H-2 host genetic factors also appear to be important to expression of recovery in H-2(b/b) F(1) mice. The mechanisms of action of these genes remain unknown.
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D005622:Friend murine leukemia virus; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D006649:Histocompatibility Antigens; D006824:Hybridization, Genetic; D007942:Leukemia, Experimental / Q000150:complications / Q000209:etiology / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009365:Neoplasm Regression, Spontaneous; D011995:Recombination, Genetic; D013163:Splenomegaly / Q000209:etiology
D006649:Histocompatibility Antigens