Cell surface antigen induced by Friend murine leukemia virus is also in the virion.
Intact particles of Friend leukemia virus derived from infectious mouse serum absorb only trace amounts of cytotoxic anti-FMR antibodies, but physical disruption of the virions by freezing and thawing, by ether extraction or by detergent treatment releases large amounts of FMR antigenic activity. Thus this antigen, previously considered to occur mainly as a neo-antigen on the surfaces of virus-infected cells and as a soluble substance in the serum of infected mice, may be primarily a virion component.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D001769:Blood / Q000382:microbiology; D002462:Cell Membrane / Q000276:immunology*; D002499:Centrifugation, Density Gradient; D002860:Chromium Radioisotopes; D003601:Cytotoxicity Tests, Immunologic; D005019:Ethyl Ethers; D005615:Freezing; D005622:Friend murine leukemia virus / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000648:ultrastructure; D013501:Surface-Active Agents; D014316:Tritium; D014529:Uridine
D000956:Antigens, Viral; D002860:Chromium Radioisotopes; D005019:Ethyl Ethers; D013501:Surface-Active Agents; D014316:Tritium; D014529:Uridine