The intracellular concentration dependence of antifolate inhibition of DNA synthesis in L1210 leukemia cells.
D000818:Animals; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007939:Leukemia L1210 / Q000201:enzymology / Q000378:metabolism*; D008727:Methotrexate / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D014316:Tritium; D013762:Tetrahydrofolate Dehydrogenase; D013936:Thymidine; D014529:Uridine; D008727:Methotrexate