title: Characterization of a new intra-H-2 recombinant separation of the Ir-RE and Ir-GLT genes.
abstract: This report characterizes the intra-H-2 crossover in the D2.GD mouse strain. Recombination occurred within the I region between the immune response (Ir) gene controlling immune responsiveness to ragweed extract (RE). Ir-RE, and the Ir gene governing responsiveness to the random linear terpolymers of glutamic acid and lysine with either tyrosine or pheylalanine (Ir-GLT and Ir-GLphi). The Ir-RE gene was tentatively located in the Ir-1A subregion and the Ir-GLT and Ir-GLphi gene(s) tentatively placed in the Ir-1B subregion. The importance of this recombinant strain to further studies on the fine structure of the I region is discussed.
mesh_terms: D000485:Allergens; D000818:Animals; D000917:Antibody Formation; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D006649:Histocompatibility Antigens; D007114:Immunization; D007073:Immunoglobulin E / Q000032:analysis; D007519:Isoantigens; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010323:Passive Cutaneous Anaphylaxis; D010944:Plants; D011108:Polymers / Q000276:immunology; D011995:Recombination, Genetic
chemical_list: D000485:Allergens; D006649:Histocompatibility Antigens; D007519:Isoantigens; D011108:Polymers; D007073:Immunoglobulin E