title: Tritiated bile acids: problems and recommendations.
abstract: Kinetic studies of cholic and chenodeoxycholic acids were carried out in three patients by simultaneous intravenous administration of appropriate pairs of (3)H- and (14)C-labeled compounds. The results obtained indicated two sources of error: chemical impurity and loss of tritium by biological exchange. Precautions are listed for use of tritiated bile acids in studies of pool sizes and turnover rates.
mesh_terms: D000328:Adult; D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002635:Chenodeoxycholic Acid / Q000008:administration & dosage / Q000378:metabolism; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000628:therapy; D002793:Cholic Acids / Q000008:administration & dosage / Q000378:metabolism; D003840:Deoxycholic Acid / Q000378:metabolism; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008722:Methods; D008875:Middle Aged; D014316:Tritium
chemical_list: D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D002793:Cholic Acids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D014316:Tritium