Pulmonary alveolar hypoxia: release of prostaglandins and other humoral mediators.
Hypoxic ventilation of isolated perfused cat lungs caused the frequent appearance in pulmonary perfusates of biologically active substances, which included prostaglandins or prostaglandin-like compounds. In anesthetized cats, inhibition of prostaglandin biosynthesis with infusions of aspirin (more than 50 milligrams per kilogram) reduced the pulmonary vasoconstrictor and bronchoconstrictor responses to hypoxic breathing.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001681:Biological Assay; D001794:Blood Pressure; D002415:Cats; D003864:Depression, Chemical; D000860:Hypoxia / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010477:Perfusion; D011453:Prostaglandins / Q000096:biosynthesis* / Q000494:pharmacology; D011650:Pulmonary Alveoli / Q000378:metabolism*; D011651:Pulmonary Artery / Q000187:drug effects; D011652:Pulmonary Circulation / Q000187:drug effects; D011667:Pulmonary Veins / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D001241:Aspirin