Oral contraceptives and increased formation of soluble fibrin.
Soluble fibrin was measured weekly for two months in 12 normal women and in 12 women on combined oestrogen-progestogen therapy (Ortho-Novin, Norinyl, Enavid, Ovral, Ovulen, Demulen). Plasma soluble fibrin concentration in women on oral contraceptives showed an increase of 97.2% (P <0.001) above that of normal women. In three cases, where each woman on the oral contraceptive served as her own control, stopping medication led to a return to normal of the plasma content of soluble fibrin.
D000293:Adolescent; D000328:Adult; D001780:Blood Coagulation Tests; D002250:Carbon Radioisotopes; D003276:Contraceptives, Oral / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005337:Fibrin / Q000032:analysis* / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008297:Male; D011372:Progestins / Q000494:pharmacology*; D012995:Solubility; D013925:Thromboplastin; D013997:Time Factors
D002250:Carbon Radioisotopes; D003276:Contraceptives, Oral; D004967:Estrogens; D011372:Progestins; D005337:Fibrin; D005340:Fibrinogen; D013925:Thromboplastin; D005998:Glycine