title: Haemoglobin Belfast 15 (A12) tryptophan leading to arginine: a new unstable haemoglobin variant.
abstract: A new unstable haemoglobin, alpha(2)beta(2)15 Trp--> Arg (Hb Belfast), with increased oxygen affinity has been found during the routine investigation of a long-stay psychiatric patient. It seemed to cause little haematological disorder. The reticulocytes synthesized normal and abnormal beta-chains at the same rate but in the circulating blood Hb Belfast amounted to only 27.5% of the total haemoglobin.
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001120:Arginine; D002250:Carbon Radioisotopes; D002852:Chromatography, Ion Exchange; D004586:Electrophoresis; D006454:Hemoglobins / Q000096:biosynthesis / Q000145:classification* / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D008297:Male; D009154:Mutation; D009660:Northern Ireland; D010100:Oxygen / Q000378:metabolism; D012563:Schizophrenia, Paranoid / Q000097:blood; D014364:Tryptophan
chemical_list: D002250:Carbon Radioisotopes; D006454:Hemoglobins; D014364:Tryptophan; D001120:Arginine; D010100:Oxygen