title: Cardiac valve replacement. The rationale for earlier operation.
abstract: Cardiac valve replacement (single or double) was carried out in 138 consecutive patients with valvular heart disease over a six-year period at the Wadsworth Veterans Administration Hospital. All but a few had functional class III or IV disease. Hospital mortality was 3.6 percent.Normothermia, coronary perfusion and beating of the heart were maintained throughout the procedure. All patients were followed at least one year and the average follow-up was four and a half years. The late mortality was 27 percent. Seventy-five percent of the late deaths were due to progressive cardiac disease. The mortality due to prosthetic valve dysfunction was 4 percent. Subjective evaluation of survivors revealed that a high percentage remained symptomatic. Only 50 percent of the total group of patients were significantly improved. The high incidence of late mortality and poor long-term functional results are contrasted to the low operative risk and improved reliability of prosthetic valves. The rationale of delaying operation until functional class III limitation develops is questioned. Earlier operation is recommended before irreversible myocardial hypertrophy and fibrosis develop.
mesh_terms: D006350:Heart Valve Prosthesis; D006801:Humans; D008722:Methods; D008875:Middle Aged; D011183:Postoperative Complications; D013997:Time Factors