title: Drinking and antidiuresis elicited by isoprenaline in the dog.
abstract: 1. Isoprenaline hydrochloride injected subcutaneously or infused intravenously caused drinking and simultaneous antidiuresis in the dog. The minimal effective dose was between 20 and 50 mug per dog.2. Isoprenaline-induced drinking was prevented by the beta-adrenergic antagonist propranolol and enhanced by the alpha-antagonist phentolamine.3. Ganglionic blockade with pentolinium or with hexamethonium did not interfere with the response.4. A delay of 1 hr after injection of 100 mug isoprenaline, before drinking was permitted, did not significantly reduce the amount of water subsequently drunk. A preload of water approximately equal to the volume of water normally drunk caused a greater reduction in water intake in some dogs.5. Isoprenaline caused an increase in heart rate and pulse pressure which lasted for between 1 and 3 hr according to dose. Central venous pressure fell, but mean arterial pressure was little altered. Haemodynamic changes preceded drinking by about 5 min.6. Infusion of isoprenaline caused drinking in the bilaterally nephrectomized dog.7. We conclude that isoprenaline is a potent stimulus to drinking in the dog and that the effect is not exclusively mediated by the renin-angiotensin system.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D004327:Drinking Behavior / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009392:Nephrectomy; D010425:Pentolinium Tartrate / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011674:Pulse / Q000187:drug effects; D013268:Stimulation, Chemical
chemical_list: D006584:Hexamethonium Compounds; D010425:Pentolinium Tartrate; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine