title: Involvement of adenosine 3',5'-monophosphate in the activation of tyrosine hydroxylase elicited by drugs.
abstract: Immediately after the injection of reserpine (16 micromoles per kilogram, intraperitoneally), aminophylline (200 micromoles per kilogram, intraperitoneally), and carbamylcholine (8.2 micromoles per kilogram, intraperitoneally), the concentration of adenosine 3',5'-monophosphate in adrenal medulla of rats is increased severalfold. The three drugs also cause a delayed increase of medullary tyrosine hydroxylase activity. Our results are consistent with the view that an increase of medullary adenosine 3',5'-monophosphate concentration is involved in the drug-induced increase of tyrosine hydroxylase activity in adrenal medulla. Experiments with tyramine (130 micromoles per kilogram, intraperitoneally) suggest that the increase of tyrosine hydroxylase activity and of adenosine 3',5'-monophosphate concentrations is independent of an increase in adrenal catecholamine turnover rate.
mesh_terms: D000313:Adrenal Medulla / Q000032:analysis / Q000201:enzymology / Q000294:innervation / Q000378:metabolism*; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism*; D003714:Denervation; D004789:Enzyme Activation / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology; D013153:Splanchnic Nerves / Q000502:physiology; D014439:Tyramine / Q000008:administration & dosage / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D000628:Aminophylline; D012110:Reserpine; D002217:Carbachol; D000242:Cyclic AMP; D014446:Tyrosine 3-Monooxygenase; D014439:Tyramine