title: Commentary. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactivity metabolites with changes in the incidence and severity of toxicity.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000818:Animals; D001345:Autoradiography; D001555:Benzene Derivatives / Q000506:poisoning; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D002273:Carcinogens / Q000378:metabolism; D002478:Cells, Cultured; D055598:Chemical Phenomena; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002621:Chemistry; D046508:Culture Techniques; D004355:Drug Stability; D005665:Furosemide / Q000009:adverse effects; D006846:Hydrocarbons, Halogenated / Q000633:toxicity; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D009153:Mutagens / Q000378:metabolism; D009336:Necrosis / Q000378:metabolism; D014116:Toxicology
chemical_list: D001555:Benzene Derivatives; D002273:Carcinogens; D006846:Hydrocarbons, Halogenated; D009153:Mutagens; D000082:Acetaminophen; D005665:Furosemide