Cell-mediated immunity to intrinsic factor in autoimmune disorders.
Evidence of cell-mediated immunity to gastric intrinsic factor was present in 86% of patients with pernicious anaemia and in at least 13% of patients with hyperthyroidism, 21% of patients with atrophic gastritis, and four out of nine (46%) patients with hypogammaglobulinaemia. Controls gave negative results. The four patients with hypogammaglobulinaemia and cell-mediated immunity to intrinsic factor had evidence of impaired gastric function.
D000361:Agammaglobulinemia / Q000276:immunology; D000752:Anemia, Pernicious / Q000209:etiology / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D002464:Cell Migration Inhibition; D003920:Diabetes Mellitus / Q000276:immunology; D005260:Female; D005756:Gastritis / Q000276:immunology; D006400:Hematocrit; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D007037:Hypothyroidism / Q000276:immunology; D007111:Immunity, Cellular; D007408:Intestinal Absorption; D007437:Intrinsic Factor / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D014805:Vitamin B 12 / Q000097:blood
D000906:Antibodies; D007437:Intrinsic Factor; D014805:Vitamin B 12