Morphine and ethanol: selective depletion of regional brain calcium.
Administration of morphine or ethanol to rats produces a decrease in regional brain calcium in vivo. This effect is selectively antagonized by the stereospecific narcotic antagonist naloxone. Reserpine and the dopamine-acetaldehyde conjugate salsolinol also produce a depletion of regional brain calcium, but only the salsolinol depletion is antagonized by naloxone. Experiments with naloxone provide evidence for two calcium-sensitive pools in the central nervous system.
D000079:Acetaldehyde / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology; D004336:Drug Antagonism; D000431:Ethanol / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013054:Spectrophotometry, Atomic
D009270:Naloxone; D000431:Ethanol; D009020:Morphine; D012110:Reserpine; D000079:Acetaldehyde; D002118:Calcium; D004298:Dopamine