Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
HL-A analysis of a family with C2 deficiency revealed evidence for close linkage between the C2 defect and the histocompatibility HL-A loci. The propositus was homozygous both for C2 deficiency and the HL-A haplotype 10,W18. Among seven children of three double backcross matings, no recombinants were found. The possible significance of such linkage is discussed.
D003165:Complement System Proteins / Q000096:biosynthesis* / Q000172:deficiency; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006720:Homozygote; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics*; D008297:Male; D010375:Pedigree
D006680:HLA Antigens; D006649:Histocompatibility Antigens; D003165:Complement System Proteins