title: Ascorbic acid deficiency in malignant diseases: a clinical and biochemical study.
abstract: In a study of the vitamin C status of 50 patients with malignant disease, 46 had leucocyte levels less than the lower limit of the normal range (18-50,μg/10(8) W.B.C.) and of these 30 had very low levels (< 12.5 μg/10(8) W.B.C.). Physical signs compatible with subclinical scurvy were frequently recorded and there was a significant decrease in capillary fragility in those with the lowest levels. Most patients had an inadequate dietary intake of ascorbic acid-containing foods and this was felt to be the major factor in producing the vitamin depletion.
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000097:blood; D001206:Ascorbic Acid Deficiency / Q000150:complications*; D001984:Bronchial Neoplasms / Q000150:complications; D002198:Capillary Fragility; D003110:Colonic Neoplasms / Q000150:complications; D004032:Diet; D006801:Humans; D007962:Leukocytes / Q000032:analysis; D008206:Lymphatic Diseases / Q000150:complications; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D012004:Rectal Neoplasms / Q000150:complications; D012614:Scurvy / Q000150:complications; D013274:Stomach Neoplasms / Q000150:complications
chemical_list: D001205:Ascorbic Acid