Long-term stability of remission in nephrotic syndrome after treatment with cyclophosphamide.
Fifty-eight children with minimal-change nephrotic lesions who relapsed repeatedly and showed toxic side effects from corticosteroids were treated with cyclophosphamide for an average of 12 weeks. The initial dose was 5 mg/kg/day. Four to seven years (mean 5.8 years) later 20 remained in remission, 34 were still relapsing, and 4 had died (two during relapses, one of measles after cyclophosphamide, and one of a brain-stem astrocytoma). The half time for the relapse-free period after treatment was 2.8 years. There was no relationship between the length of treatment with cyclophosphamide and the stability of remission within the limits studied.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008598:Menstruation / Q000187:drug effects; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000401:mortality; D011247:Pregnancy; D011507:Proteinuria / Q000188:drug therapy; D012008:Recurrence; D012075:Remission, Spontaneous; D012709:Serum Albumin / Q000032:analysis; D012737:Sex Factors; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D012709:Serum Albumin; D003520:Cyclophosphamide