Increased antitumor activity of cyclophosphamide (Endoxan) following pretreatment with inducer of drug-metabolizing enzymes (cytochrome P-450).
D000478:Alkylation; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology; D003520:Cyclophosphamide / Q000378:metabolism / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D004347:Drug Interactions; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013053:Spectrophotometry
D065607:Cytochrome P-450 Enzyme Inhibitors; D003580:Cytochromes; D002701:Chloramphenicol; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital