title: Properties of Corynebacterium acnes bacteriophage and description of an interference phenomenon.
abstract: Nine virulent bacteriophages of the anaerobe Corynebacterium (Propionibacterium) acnes, the P-a series, are DNA phages, with long, curved nonretractile tails (130 nm) without tail plates or fibers. They have isometric heads (420 by 460 nm), and are placed in Bradley's group B-1. There is permanent plaque suppression at highest phage concentrations. After 100- to 1,000-fold dilution, plaques are evident. The latent period is 1 h and burst size 25. Cross-neutralization data of antisera for the nine phages are similar. There is an unexplained precipitous drop in plaque-forming units during the first 5 min of neutralization, after which the rate is linear for 2 h. They are sensitive to pH extremes but are partially protected even at pH 4 or 9 by storage at 4 C. They are resistant to ether and chloroform and are inactivated within 10 min at 70 C.
mesh_terms: D000942:Antigens, Bacterial; D001435:Bacteriophages / Q000187:drug effects / Q000254:growth & development / Q000276:immunology / Q000648:ultrastructure; D002725:Chloroform / Q000494:pharmacology; D003352:Corynebacterium; D004267:DNA Viruses; D004352:Drug Resistance, Microbial; D005019:Ethyl Ethers / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008242:Lysogeny; D008854:Microscopy, Electron; D009500:Neutralization Tests; D011425:Propionibacterium acnes; D013696:Temperature; D014762:Viral Interference; D014764:Viral Proteins
chemical_list: D000942:Antigens, Bacterial; D005019:Ethyl Ethers; D014764:Viral Proteins; D002725:Chloroform