Major hepatic resection using vascular isolation and hypothermic perfusion.
The technique and results of 29 major hepatic resections using the method of complete vascular isolation and hypothermic perfusion of the liver are reported. The method enables the surgeon to perform otherwise difficult or impossible resections through chilled bloodless hepatic parenchyma. Major intrahepatic vascular structures can thus be recognized and controlled readily under clear vision. Direct neoplastic involvement of, or tumor thrombi in the portal vein, hepatic vein or vena cava, can be successfully dealt with by appropriate surgical measures. The operative mortality was 10.3% for this series which included many tumors previously deemed unresectable. The technical detail and intraoperative physiologic monitoring crucial to success in the use of the method are described. It is hoped that with the widened scope of resectability afforded by this technique, and the use of adjuvant chemotherapy, the currently experienced low cure rates for hepatic cancer can be improved.
D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006498:Hepatectomy / Q000150:complications / Q000379:methods* / Q000401:mortality; D006503:Hepatic Veins; D006801:Humans; D007036:Hypothermia, Induced; D008026:Ligation; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000188:drug therapy / Q000601:surgery*; D008727:Methotrexate / Q000627:therapeutic use; D008991:Monitoring, Physiologic / Q000706:statistics & numerical data; D010477:Perfusion; D011169:Portal Vein; D011183:Postoperative Complications; D011877:Radionuclide Imaging; D013369:Subphrenic Abscess / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology; D013667:Technetium; D014684:Venae Cavae
D003609:Dactinomycin; D013667:Technetium; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate