Histocompatibility antigens in active chronic hepatitis and primary biliary cirrhosis.
The frequency of antigens HL-A 1 (48%) and HL-A 8 (52%) in 54 patients with active chronic hepatitis from south-east England was significantly higher than in 89 control subjects from the same region (22% and 17% respectively). No correlation could be detected with the age and sex of the patients or with the presence of a particular immunological abnormality but the frequency of HL-A 1 and HL-A 8 was much lower in the nine patients who were positive for HBAg than in the 45 HBAg-negative cases. These results provide further evidence of the importance of genetic factors in active chronic hepatitis. In contrast the frequency of HL-A 1 and HL-A 8 in primary biliary cirrhosis, both in 45 patients from south-east England and in 28 patients from western Scotland, was not significantly different from that found in control groups from the same regions.
D000367:Age Factors; D002908:Chronic Disease; D004739:England; D005260:Female; D006505:Hepatitis / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008297:Male; D012606:Scotland; D012737:Sex Factors
D006511:Hepatitis B Antigens; D006649:Histocompatibility Antigens