Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship?
In both normal volunteers and in patients with primary hyperparathyroidism, the induction of a metabolic alkalosis by infusion of sodium bicarbonate results in a decrease in serum calcium ion and in an increase of circulating parathyroid hormone concentrations. Bicarbonate infusion may serve in man as a new provocative test for release of parathyroid hormone. Furthermore, we speculate that the metabolic alkalosis which is found at times in patients with the Zollinger-Ellison syndrome and severe peptic ulcer disease may result in parathyroid gland stimulation.
D000328:Adult; D000368:Aged; D000471:Alkalosis / Q000097:blood* / Q000150:complications / Q000209:etiology; D001639:Bicarbonates; D002118:Calcium / Q000097:blood*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D006961:Hyperparathyroidism / Q000097:blood* / Q000150:complications*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications; D010281:Parathyroid Hormone / Q000097:blood*; D010437:Peptic Ulcer / Q000097:blood* / Q000150:complications; D012965:Sodium Chloride; D015043:Zollinger-Ellison Syndrome / Q000150:complications
D001639:Bicarbonates; D005755:Gastrins; D010281:Parathyroid Hormone; D012965:Sodium Chloride; D002118:Calcium