The hemostatic effect of bovine peptide-B from fibrinogen.
Bovine peptide-B from fibrinogen was active in the hemostasis of rat tail arterioles. The time of bleeding exhibits an inverse log proportionality to the concentration of bovine peptide-B. The peptide produced a 10-fold decrease in the time of bleeding at the highest concentration tested. Prolonged incubation of the peptide with the system was unnecessary and it appeared to participate immediately as a hemostatic agent. These findings suggest that hemostasis was due to vasoconstriction since coagulation time remained constant as the bleeding time decreased with increasing concentration of peptide-B. Bovine peptide-B is interpreted as a physiological substance which probably acts on some smooth muscle receptor.
D000818:Animals; D001777:Blood Coagulation; D002417:Cattle; D002845:Chromatography; D004586:Electrophoresis; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis; D006490:Hemostatics; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D006490:Hemostatics; D010455:Peptides; D005340:Fibrinogen