The effect of oxytetracycline on insulin resistance in obese mice.
1. Chronic oxytetracycline treatment was found to improve the insulin resistance of the obese-hyperglycaemic mouse. 2. The improved response to insulin was accompanied by decreased concentrations of circulating insulin and glucose, by a decrease in the lipid content of the liver and by an increase in the insulin-receptor sites of the liver and adipose tissue. 3. The increase in insulin-receptor sites preceded the fall in blood glucose. 4. Comparable studies done on food-restricted animals indicated that although chronic food restriction corrected the hyperinsulinaemia it did not restore the insulin-receptor sites or the hyperglycaemia.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004032:Diet; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood / Q000494:pharmacology; D007333:Insulin Resistance; D007545:Isoproterenol / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009708:Nucleotidases / Q000378:metabolism; D010118:Oxytetracycline / Q000494:pharmacology*; D011955:Receptors, Drug; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D011955:Receptors, Drug; D009708:Nucleotidases; D007545:Isoproterenol; D010118:Oxytetracycline