The identification of 3,3', 5,5',-tetraiodothyroformic acid within the rat liver.
Homogenized rat livers were extracted with organic solvents and the extracts converted into more readily volatile derivatives (trimethylsilylmethyl esters and permethyl esters). Combined g.l.c.-mass-spectrometric analysis identified the presence of tetraiodothyroformate. It is postulated that mitochondrial beta-oxidation of tetraiodothyropyruvate results in the formation of this apparently undescribed metabolite.
D000818:Animals; D002849:Chromatography, Gas; D004952:Esters; D007455:Iodine / Q000378:metabolism; D008099:Liver / Q000032:analysis* / Q000378:metabolism; D013058:Mass Spectrometry; D008722:Methods; D051381:Rats; D013329:Structure-Activity Relationship; D013963:Thyroid Hormones / Q000378:metabolism; D013974:Thyroxine / Q000031:analogs & derivatives* / Q000032:analysis; D014020:Tissue Extracts
D004952:Esters; D013963:Thyroid Hormones; D014020:Tissue Extracts; D007455:Iodine; D013974:Thyroxine