title: Luminal distension as a possible consequence of experimental intestinal perfusion.
abstract: In an experimental jejunal perfusion study, distress in healthy subjects occurred during eight out of 16 perfusions in which intestinal secretion was provoked. Calculation demonstrates the volumetric consequences of inadequate recovery of secretory perfusates, and analysis of the perfusion studies shows that distress was significantly associated with poor recovery of the perfusate. These observations are pertinent to increasing interest in the phenomenon of intestinal fluid secretion.
mesh_terms: D002250:Carbon Radioisotopes; D002635:Chenodeoxycholic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D003840:Deoxycholic Acid / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D003967:Diarrhea / Q000139:chemically induced; D006000:Glycocholic Acid / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007410:Intestinal Diseases / Q000209:etiology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects; D010477:Perfusion / Q000009:adverse effects*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D002250:Carbon Radioisotopes; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D006000:Glycocholic Acid