Pulmonary mechanical effects of experimental lung embolism and their modification by bronchodilator drugs in the guinea-pig.
In the anaesthetized guinea-pig micro-embolism induced by barium sulphate causes marked increases in pulmonary resistance and decreases in pulmonary compliance. Bronchodilator drugs prevent these changes with salbutamol showing much greater activity on pulmonary resistance changes than compliance changes. The results are discussed with regard to the site of action in the respiratory tree and potential clinical use.
D000420:Albuterol / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D001464:Barium; D001993:Bronchodilator Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000503:physiopathology*
D001993:Bronchodilator Agents; D001464:Barium; D000628:Aminophylline; D010208:Papaverine; D007545:Isoproterenol; D000420:Albuterol