Antagonism of the spinal action of diazepam by semicarbazide.
In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2-4.5 h prior to the administration of diazepam (1-4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered 1 h later. The possibility of a link between diazepam and spinal gamma-aminobutyric acid is suggested and discussed.
D000613:Aminobutyrates / Q000378:metabolism; D000818:Animals; D002415:Cats; D003975:Diazepam / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D007796:Laminectomy; D011736:Pyridoxine / Q000008:administration & dosage / Q000494:pharmacology; D012663:Semicarbazides / Q000008:administration & dosage / Q000494:pharmacology*; D013116:Spinal Cord / Q000502:physiology; D013126:Spinal Nerve Roots / Q000502:physiology
D000613:Aminobutyrates; D012663:Semicarbazides; D011736:Pyridoxine; D003975:Diazepam