Reversal learning enhanced by lysergic acid diethylamide (LSD): concomitant rise in brain 5-hydroxytryptamine levels.
1 Small doses of lysergic acid diethylamide (LSD) (12.5-50 mug/kg) consistently facilitated learning of a brightness discrimination reversal.2 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 mug/kg).3 LSD, but not BOL-148, caused a small but significant increase in brain 5-hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 mug/kg.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012193:Reversal Learning / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D013268:Stimulation, Chemical; D013997:Time Factors
D012701:Serotonin; D008238:Lysergic Acid Diethylamide