Some inhibitory effects of (--)-emetine on growth of Ehrlich ascites carcinoma.
(-)-Emetine has little or no effect on O(2) consumption of Ehrlich ascites-cell suspensions or on the viability of transplanted Ehrlich ascites-tumour cells exposed to, or incubated with, the drug in vitro before inoculation into new-host mice. (-)-Emetine administered as a single injection to mice bearing Ehrlich ascites-tumour cells slows the growth rate of the tumour. The subcutaneous or intraperitoneal injection of the drug depresses protein and DNA synthesis of the tumour cells in vivo in a reversible manner. Mice bearing ascitic sarcoma 180 or Ehrlich ascites-tumour cells when given a course of treatment with (-)-emetine or (-)-O-methyltubulosine have a substantially lower tumour load than untreated controls and correspondingly longer survival times.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004640:Emetine / Q000031:analogs & derivatives / Q000494:pharmacology*; D007930:Leucine / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects; D012510:Sarcoma 180 / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; C009778:O-methyltubulosine; D007930:Leucine; D013936:Thymidine; D004640:Emetine