[Test of cellulose and cellulose derivatives for carcinogenic activity in rats, mice and rabbits].
Activated cellulose, p-aminobenzylcellulose, p-hydroxybenzylcellulose, cellulose-m-aminobenzoxymethylether and cellulose-m-hydroxybenzoxymethylether which are used as highmolecular inert components for the preparation of immunoadsorbents, have been tested for carcinogenic activity in Wistar-rats and CBA-mice by the subcutaneous and intramuscular route of administration. In the same manner the coupling products have been tested in rats, mice and rabbits of diazotized p-aminobenzylcellulose and cellulose-m-aminobenzoxymethylether with a) human gammaglobulin [(cellulose-p-benzylether)-azogammaglobulin and (cellulose-m-benzoxymethylether)-azogammaglobulin respectively] and b) 1-(m-hydroxyphenyl)-flavozole derivatives of saccharides of the isomaltodextrin- and maltodextrin series [saccharide-1-(3 ft.-hydroxy-4 ft.-(resp.-6 ft.-or-2 ft.-) [cellulose-p-benzylether]-azophenyl)-flavazoles and saccharide-1-(3 ft.-hydroxy-4 ft.-(resp. -6 ft;-or-2 ft.-) [cellulose-m-benzoxymethylether]-azophenyl)-flavazoles with isomaltotriose, isomaltotetraose, isomaltopentaose, isomaltohexaose, isomaltooctaose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltooctaose as saccharide moieties]. No tumours were found in rabbits. No statistical significant difference could be stated between the tumour incidence of experimental animals and controls in the rat and mouse groups.
D000818:Animals; D002273:Carcinogens; D002482:Cellulose / Q000009:adverse effects* / Q000031:analogs & derivatives; D005260:Female; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D008320:Maltose / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D002273:Carcinogens; D008320:Maltose; D002482:Cellulose
PRUFUNG VON ZELLULOSE UND ZELLULOSE-DERIVATEN AUF KANZEROGENE WIRKUNG IN RATTEN, MAUSEN UND KANINCHEN