Anion effects on pyruvate kinase.
Rabbit muscle pyruvate kinase is shown not to be activated by several anions (acetate, chloride, lactate, nitrate and sulphate) when tested as their tetramethylammonium salts. This contradicts the conclusions of Focant & Watts (1973).
D000085:Acetates / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D003956:Dialysis; D004789:Enzyme Activation / Q000187:drug effects; D007773:Lactates / Q000494:pharmacology; D008968:Molecular Conformation; D009566:Nitrates / Q000494:pharmacology; D010728:Phosphoenolpyruvate; D011188:Potassium / Q000494:pharmacology; D011770:Pyruvate Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology; D013053:Spectrophotometry; D013431:Sulfates / Q000494:pharmacology
D000085:Acetates; D002712:Chlorides; D007773:Lactates; D009566:Nitrates; D000644:Quaternary Ammonium Compounds; D013431:Sulfates; D010728:Phosphoenolpyruvate; D012964:Sodium; D011770:Pyruvate Kinase; D011188:Potassium