Pathways of gluconeogenesis from L-serine in the neonatal rat.
Gluconeogenesis from amino acid precursors was increased in the perfused liver of neonatal rats compared with that of adults. Quinolinate (5mm) was less inhibitory to glucose formation from serine and hydroxyproline in the neonatal rat than in the adult, suggesting that the main route for glucose synthesis from these precursors in neonatal liver does not involve pyruvate as an intermediate.
D000818:Animals; D005943:Gluconeogenesis; D005947:Glucose / Q000096:biosynthesis; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011773:Pyruvates / Q000378:metabolism; D011805:Quinolinic Acids / Q000494:pharmacology; D051381:Rats; D012694:Serine / Q000378:metabolism*
D011773:Pyruvates; D011805:Quinolinic Acids; D012694:Serine; D005947:Glucose; D006909:Hydroxyproline