[In vitro effects of saluretics, osmotic pressure and the acidity of the medium on the evaluated globular volume in chronic bronchopneumopathies by means of microhematocrit].
The in vitro effect of diuretics, osmotic pressure and acidity of the medium on red cell volume was examined. The results showed that:1) diuretics lead to a reduction in volume;2) this reduction is enhanced at higher concentrations; 3) the effect is more noticeable in more diluted blood; 4) a decrease in volume is also displayed by cells whose volume has been increased by hypo-osmotic solutions; 5) this effect is not apparent when cell volume is reduced to the minium by hypersmotic solutions;6) the effect of the pH value is only felt in the case of extreme variations.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D001581:Benzothiadiazines / Q000494:pharmacology; D001810:Blood Volume / Q000187:drug effects*; D002908:Chronic Disease; D004232:Diuretics / Q000494:pharmacology*; D005665:Furosemide / Q000494:pharmacology; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009997:Osmotic Pressure; D012140:Respiratory Tract Diseases / Q000097:blood*; D013997:Time Factors
D001581:Benzothiadiazines; D004232:Diuretics; D005665:Furosemide
Effetti in "vitro" di saluretici, della pressione osmotica e dell'aciditå del mezzo sul volume globulare valutato, nei broncopneumopatici cronici, mediante microematocrito