Electroimmunoassay of plasma subunits-a and -s in a case of congenital fibrin stabilizing factor deficiency.
Antigenic material related to the fibrin stabilizing factor (Factor XIII-FSF) has been found in all the examined patients with congenital deficiency, albeit in reduced amount. Recently, Bohn et al. (1973) showed that plasma Factor-XIII is composed by two subunits, A (or a) and S (or b); the former active protein, the latter probably FSF-vinding protein. Using specific anti-S and anti-A antisera the Authors found, in a case of congenital deficiency of factor XIII, absence of subunit A. Subunit S presented abnormal behaviour as demonstrated by means of quantitative immunoelectrophoresis according to Laurell.
D001780:Blood Coagulation Tests; D005176:Factor XIII / Q000032:analysis; D005177:Factor XIII Deficiency / Q000151:congenital / Q000175:diagnosis*; D007106:Immune Sera; D007118:Immunoassay / Q000379:methods*; D007122:Immunoelectrophoresis / Q000379:methods
D007106:Immune Sera; D005176:Factor XIII