title: Effect on nitrous oxide on the anaesthetic requirement of enflurane.
abstract: The effect of nitrous oxide on the minimum alveolar concentration of enflurane required to prevent movement in response to skin incision in 50% of subjects (MAC) has been investigated in two groups of 16 patients. The end-tidal enflurane concentration was held constant for 25-36 min in order to equilibrate the brain with the alveolar anasthetic partial pressure. When nitrous oxide (30%) was present in the inspired mixture the MAC of enflurane was 1.17%; the value decreased to 0.57% when 70% nitrous oxide was used.
mesh_terms: D000328:Adult; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000032:analysis; D001831:Body Temperature; D003243:Consciousness / Q000187:drug effects; D004336:Drug Antagonism; D004357:Drug Synergism; D004737:Enflurane / Q000008:administration & dosage*; D006801:Humans; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology*; D011650:Pulmonary Alveoli; D012119:Respiration; D013147:Spirometry
chemical_list: D000777:Anesthetics; D008738:Methyl Ethers; D004737:Enflurane; D009609:Nitrous Oxide