title: Studies of drugs given before anaesthesia. XXII: Metoclopramide.
abstract: Metoclopramide hastens emptying of the stomach. Since it may be given to patients before operation, the sedative and toxic effects of 10- and 20-mg does given i.m. were studied in patients and student volunteers. Saline and diazepam 10 mg were used as placebo and reference drugs. Neither dose of metoclopramide had as good a sedative effect as diazepam 10 mg. Restlessness occurred in a small number of patients but there were no other side effects apart from dryness of the mouth.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003243:Consciousness / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007273:Injections, Intramuscular; D008787:Metoclopramide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D010919:Placebos; D011229:Preanesthetic Medication; D011674:Pulse / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D006993:Hypnotics and Sedatives; D010919:Placebos; D012965:Sodium Chloride; D008787:Metoclopramide; D003975:Diazepam