In vitro inhibition of Coccidioides immitis strains with amphotericin B plus rifampin.
Rifampin was shown in vitro to decrease the amphotericin B minimal inhibitory concentrations of all of 10 strains of Coccidioides immitis tested. These decreases ranged from two- to fourfold and occurred with rifampin concentrations of 10 to 40 mug/ml. Rifampin alone was without effect.
D000666:Amphotericin B / Q000494:pharmacology*; D003045:Coccidioides / Q000187:drug effects*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000494:pharmacology*
D000666:Amphotericin B; D012293:Rifampin