The biphasic effect of small doses of tranylcypromine on the spontaneous motor activity and learned conditioned behaviour in rats.
Tranylcypromine (TCP), a monoamine-oxidaone inhibitor with amphetamine-like property, has at first a depressant effect and 5 h later a stimulating effect on sponataneous motor activity and learned conditioned behaviour. This latter effect can be demonstrated by means of a modified conditioned avoidance response schedule and a specific time-schedule interval. While the depressant effect of tranylcypromine may be due to the initial increase of brain serotonin caused by this drug, its delayed stimulating effect is, very likely, related to norepinephrine brain increase occurring a few hours after TCP administration.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D003864:Depression, Chemical; D005260:Female; D009043:Motor Activity / Q000187:drug effects*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013268:Stimulation, Chemical; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology*
D012701:Serotonin; D014191:Tranylcypromine; D009638:Norepinephrine