Regeneration of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6-hydroxydopamine.
1. Fluorescence histochemical and pharmacological studies were made of the noradrenergic innervation of inferior venae cavae and left atria from 2- and 6-week-old chicks before, and following, treatment with 6-hydroxydopamine.2. Noradrenergic nerves in the younger animals appeared to be relatively resistant to the toxic effects of 6-hydroxydopamine.3. In the older animals, the time course of recovery from the effects of 6-hydroxydopamine appeared to reflect the rate of regeneration of destroyed noradrenergic nerves.4. Marked presynaptic supersensitivity to adrenaline and noradrenaline was observed in left atria and inferior venae cavae following treatment with 6-hydroxydopamine.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002645:Chickens; D003042:Cocaine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004837:Epinephrine / Q000494:pharmacology; D006145:Guanethidine / Q000494:pharmacology; D006321:Heart / Q000294:innervation*; D006325:Heart Atria / Q000294:innervation; D006651:Histocytochemistry; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008856:Microscopy, Fluorescence; D009119:Muscle Contraction / Q000187:drug effects; D009416:Nerve Regeneration; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D012601:Scopolamine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology; D013997:Time Factors; D014682:Vena Cava, Inferior / Q000294:innervation*
D006892:Hydroxydopamines; D012601:Scopolamine; D003042:Cocaine; D009638:Norepinephrine; D004837:Epinephrine; D006145:Guanethidine