Effect of ether anaesthesia on pharmacokinetics of N-(2 hydroxy ethyl)2-phenyl ethyl carbamate: inhibition of its enterohepatic circulation.
1 The effect of the ether anaesthesia on the plasma half-life of N-(2 hydroxy ethyl) 2-phenyl ethyl carbamate has been studied in rats.2 The plasma half-life of the carbamate was considerably shorter in animals anaesthetized with ether prior to drug administration than in control rats.3 The longer plasma half-life of the carbamate in control animals was shown to be due to enterohepatic circulation.4 Inhibition of this phenomenon by ether was responsible for the shorter plasma half-life of the carbamate in animals anaesthetized with this agent before drug administration.5 The possible mechanisms by which the ether-induced effect is brought about are discussed.
D000667:Ampicillin / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D001646:Bile / Q000378:metabolism; D001652:Bile Ducts / Q000502:physiology; D002219:Carbamates / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism; D002855:Chromatography, Thin Layer; D004986:Ether / Q000494:pharmacology*; D005019:Ethyl Ethers / Q000494:pharmacology*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008026:Ligation; D008102:Liver Circulation; D008297:Male; D010477:Perfusion; D051381:Rats; D013997:Time Factors; D014316:Tritium; D014520:Urethane / Q000008:administration & dosage / Q000494:pharmacology
D002219:Carbamates; D005019:Ethyl Ethers; D004986:Ether; D014316:Tritium; D014520:Urethane; D000667:Ampicillin