The effect of delta1-tetrahydrocannabinol on the release of (3H-(-)-noradrenaline from the isolated vas deferens of the rat.
1 The amount of tritium released upon transmural stimulation of the isolated vas of the rat incubated with [(3)H]-Delta(1)-tetrahydrocannabinol (THC) (2.8 muM) was significantly greater than the non-stimulated overflow.2 There was no difference between non-stimulated overflow and the effect of transmural stimulation of vasa equilibrated with [(14)C]-sorbitol (6.5 mg/ml).3 The difference between non-stimulated and stimulated efflux from vasa equilibrated with [(3)H]-Delta(1)-THC was abolished in rats pretreated for 24 h with 6-hydroxydopamine (250 mg/kg).4 The amount of tritium released upon transmural stimulation of the vas incubated with [(3)H]-noradrenaline (6 muM) was significantly greater than the non-stimulated overflow.5 Delta(1)-THC (560 nM and 14 muM) caused a significant dose-dependent reduction of both non-stimulated and stimulated tritium efflux, especially the latter.
D000818:Animals; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000378:metabolism / Q000494:pharmacology*; D004558:Electric Stimulation; D006892:Hydroxydopamines / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013012:Sorbitol / Q000378:metabolism; D013997:Time Factors; D014649:Vas Deferens / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology
D006892:Hydroxydopamines; D013012:Sorbitol; D013759:Dronabinol; D009638:Norepinephrine