Some shortcomings of direct intraventricular injection in mice.
The use of X-ray photography following injection of iophendylate to verify that intraventricular injections in mice have been satisfactorily accomplished is misleading since it fails to detect leakage into the periphery. Radioactive labelling reveals that a substantial proportion of the injected material is rapidly carried to the periphery in the bloodstream.
D000818:Animals; D001810:Blood Volume; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D002250:Carbon Radioisotopes; D002552:Cerebral Ventricles; D003287:Contrast Media; D005227:Fatty Acids; D007267:Injections; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D051379:Mice; D011700:Putrescine / Q000378:metabolism; D011859:Radiography; D012436:S-Adenosylmethionine / Q000378:metabolism
D002250:Carbon Radioisotopes; D003287:Contrast Media; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D012436:S-Adenosylmethionine; D011700:Putrescine