Apomorphine-induced and pilocarpine-induced hypothermia in mice: drug interactions and changes in drug sensitivity after caudate nucleus lesions.
1 Apomorphine and pilocarpine each produced dose-dependent hypothermic effects in mice. However, the dose-response curve for pilocarpine was steeper than that for apomorphine.2 Bilateral lesions of the caudate nucleus produced a permanent decrease in sensitivity to apomorphine but had no effect on sensitivity to pilocarpine.3 Apomorphine and pilocarpine had synergistic effects; i.e. the hypothermic effect was greater following a combination of the drugs than following either drug alone.4 The effect of apomorphine was antagonized by either haloperidol or scopolamine; only scopolamine antagonized the effect of pilocarpine.5 These results suggest that a mechanism involving dopaminergic neurones in the caudate nucleus has a modulatory role in temperature regulation.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D002421:Caudate Nucleus / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010862:Pilocarpine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology; D013997:Time Factors
D010862:Pilocarpine; D012601:Scopolamine; D006220:Haloperidol; D001058:Apomorphine