Sensitization of noradrenaline responses by inhibitors of extraneuronal uptake in a coronary artery preparation.
Inhibition of neuronal uptake with cocaine had no significant effect on the dose-response curve to noradrenaline in strips of beef coronary artery. However, responses were enhanced about 3-fold by 17beta-oestradiol and the haloalkylamine GD-131, two known inhibitors of extraneuronal uptake.
D000588:Amines / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D003042:Cocaine / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011409:Propylene Glycols / Q000494:pharmacology
D000588:Amines; D011409:Propylene Glycols; D004958:Estradiol; D011189:Potassium Chloride; D003042:Cocaine; D009638:Norepinephrine