Stimulation of rat gastric adenylate cyclase by histamine and histamine analogues and blockade by burimamide.
Histamine, 4-methylhistamine, 3-(beta-aminoethyl)-1,2,4 triazole and betazole, in that order, stimulated adenylate cyclase prepared from rat gastric tissue in a dose-dependent manner. Burimamide, an H(2)-receptor blocking agent, in concentrations of 1-5 x 10(-6) M antagonized this effect. The data lend some support to the hypothesis that elevated levels of cyclic adenosine 3',5'-monophosphate may be involved in histamine-stimulated gastric secretions and that H(2)-receptors are associated with adenylate cyclase.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002049:Burimamide / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis / Q000494:pharmacology*; D066298:In Vitro Techniques; D051381:Rats; D013268:Stimulation, Chemical; D013270:Stomach / Q000201:enzymology*; D013890:Thiourea / Q000031:analogs & derivatives*
D006632:Histamine; D000262:Adenylyl Cyclases; D013890:Thiourea; D002049:Burimamide