Pharmacology of cephalothin in the biliary tract of humans.
Serum and biliary tract levels of cephalothin were determined in a large series of patients. Serum cephalothin levels in the therapeutic range were present at 1 h after a single dose of the antibiotic in only 4 of 39 (10.3%) subjects. Therapeutic bile cephalothin levels were achieved in only 2.4% of all subjects, and this occurred between 40 and 70 min after the administration of the antibiotic.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001659:Biliary Tract / Q000378:metabolism*; D001681:Biological Assay; D002512:Cephalothin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D003135:Common Bile Duct / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002512:Cephalothin