Alterations in cholesterol and fatty acid biosynthesis in rat liver homogenates by aryloxy acids.
2,4-Dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid inhibited the incorporation of [2-(14)C]mevalonate into cholesterol and non-saponifiable lipids. Both compounds inhibited the conversion of [1-(14)C]isopentenyl pyrophosphate into cholesterol and the synthesis of cholesterol and fatty acids from [2-(14)C]acetate. There was no inhibition of the conversion of [1-(14)C]mevalonate into CO(2). At low concentrations (0.5mm) of the compounds there was a stimulation of acetate incorporation into fatty acids.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000494:pharmacology*; D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D000085:Acetates / Q000378:metabolism; D002250:Carbon Radioisotopes; D002784:Cholesterol / Q000096:biosynthesis*; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008798:Mevalonic Acid / Q000378:metabolism
D000085:Acetates; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D015084:2,4-Dichlorophenoxyacetic Acid; D002784:Cholesterol; D015085:2,4,5-Trichlorophenoxyacetic Acid; D008798:Mevalonic Acid