Microbial transformation of methyl 5(6)-butyl-2-benzimidazolecarbamate.
The anthelmintic agent methyl 5(6)-butyl-2-benzimidazolecarbamate (Parbendazole) was transformed to two of its animal metabolites, methyl 5(6)-(4-hydroxybutyl)-2-benzimidazolecarbamate and methyl 5(6)-3-(carboxypropyl)-2-benzimidazolecarbamate, by the filamentous fungus Cunninghamella bainieri ATCC 9244. The transformation pathway was shown to be through the 4-hydroxybutyl product to the 3-carboxypropyl product. The reaction favored accumulation of the latter product.
D000871:Anthelmintics / Q000378:metabolism*; D001345:Autoradiography; D001419:Bacteria / Q000378:metabolism; D001562:Benzimidazoles / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002219:Carbamates / Q000378:metabolism*; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000378:metabolism*; D009090:Mucorales / Q000378:metabolism*; D013045:Species Specificity; D015003:Yeasts / Q000378:metabolism
D000871:Anthelmintics; D001562:Benzimidazoles; D002219:Carbamates; D002250:Carbon Radioisotopes