Influence of exogenous interferon on the peripheral white blood cell count in mice.
The effect of interferon (IF) injected intraperitoneally on the peripheral white blood-cell (WBC) count in mice was studied. Mouse serum or brain IF produced in vivo in different mouse strains by injecting various viral inducers depressed the lymphocyte count from 3 to 24 h after the injection. The effect was correlated to the antiviral titer of the preparations. The inhibitory factor exhibited physico-chemical properties of IF. Crude IF preparations obtained from mouse cell cultures, human IF and mock preparations devoid of anti-viral activity exerted no lymphocytopenic effect.
D000818:Animals; D002478:Cells, Cultured; D003864:Depression, Chemical; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007274:Injections, Intraperitoneal; D007372:Interferons / Q000008:administration & dosage / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL
D007372:Interferons