Trismus pseudocamptodactyly syndrome: Dutch-Kentucky syndrome.
A hand, foot, and mouth combination of anomalies, which is apparent on motion, has been traced through eight generations of a southern Appalachian family. The clinical features from birth to old age are presented, and attention is called to the handicapping aspects. There is a great variability in severity of the trait. Inheritance occurs as an autosomal dominant trait, but there are fewer affected persons than expected, especially females.
D000015:Abnormalities, Multiple / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005532:Foot Deformities, Congenital; D006228:Hand Deformities, Congenital; D006801:Humans; D007231:Infant, Newborn; D007629:Kentucky; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging; D008875:Middle Aged; D009056:Mouth Abnormalities / Q000235:genetics; D009426:Netherlands / Q000208:ethnology; D010375:Pedigree; D011859:Radiography; D013577:Syndrome; D014313:Trismus / Q000235:genetics*