Carnitine and trimethylaminobutyrate synthesis in rat tissues.
Liver and testis slices convert 6-N-trimethyl-lysine into 4-N-trimethylaminobutyrate and carnitine. Adipose, skeletal muscle, heart, or kidney tissues metabolize trimethyl-lysine into trimethylaminobutyrate but not into carnitine. Trimethylaminobutyrate hydroxylation, forming carnitine, occurs in liver and to a minor degree in testis. Liver is the primary site of carnitine biosynthesis in the rat.
D000273:Adipose Tissue / Q000378:metabolism; D000613:Aminobutyrates / Q000378:metabolism*; D000818:Animals; D002331:Carnitine / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D013737:Testis / Q000378:metabolism
D000613:Aminobutyrates; D002331:Carnitine