title: Ribonuclease-sensitivity of covalently closed rat liver mitochondrial deoxyribonucleic acid.
abstract: Preparations of covalently closed mitochondrial DNA of rat liver contain 10-30% of molecules that are converted into relaxed circular molecules after treatment with ribonuclease. Control experiments, with covalently closed bacteriophage PM2 DNA, indicate that ribonuclease-sensitivity cannot be induced either by depurination or by incubation with reducing agents.
mesh_terms: D000818:Animals; D001435:Bacteriophages; D002499:Centrifugation, Density Gradient; D004267:DNA Viruses; D004270:DNA, Circular; D004272:DNA, Mitochondrial; D004279:DNA, Viral; D003851:Deoxyribonucleases; D003956:Dialysis; D008297:Male; D008930:Mitochondria, Liver; D011549:Pseudomonas; D051381:Rats; D012260:Ribonucleases
chemical_list: D004270:DNA, Circular; D004272:DNA, Mitochondrial; D004279:DNA, Viral; D003851:Deoxyribonucleases; D012260:Ribonucleases