Fidelity of deoxyribonucleic acid polymerases from normal and leukaemic human cells in polydeoxynucleotide replication.
Although the relative incorporation of incorrect nucleotide (dCTP or dGTP) into poly(dA-dT).poly(dA-dT) by partially purified 3-4S DNA polymerase from normal or leukaemic human cells was four to five times higher than that by the 6-7S DNA polymerase, no significant differences in the infidelity of these polymerases between normal and leukaemic cells were noted.
D000328:Adult; D004254:DNA Nucleotidyltransferases; D003854:Deoxyribonucleotides / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000201:enzymology*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D011119:Polynucleotides / Q000096:biosynthesis*
D003854:Deoxyribonucleotides; D011119:Polynucleotides; D004254:DNA Nucleotidyltransferases