The metabolism of phenolic acids in the rat.
Some of the enzyme systems in the formation of p-hydroxybenzoate from tyrosine have been studied in the rat liver in vitro. The conversion of p-hydroxycinnamate into p-hydroxybenzoate, which was found in rat liver mitochondria showed a number of differences when compared with the beta-oxidation of fatty acids. Studies with p-hydroxy[U-(14)C]cinnamate indicated that (14)CO(2) was released during the formation of p-hydroxybenzoate. The formation of p-hydroxycinnamate from tyrosine of p-hydroxyphenyl-lactate could not be demonstrated in vitro. The interconversion of p-hydroxycinnamate and p-hydroxyphenylpropionate was demonstrated in rat liver mitochondria.
D000818:Animals; D001565:Benzoates / Q000096:biosynthesis*; D002245:Carbon Dioxide / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D002854:Chromatography, Paper; D002934:Cinnamates / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010636:Phenols / Q000378:metabolism*; D011422:Propionates / Q000378:metabolism; D051381:Rats; D014443:Tyrosine / Q000378:metabolism*
D001565:Benzoates; D002250:Carbon Radioisotopes; D002934:Cinnamates; D005227:Fatty Acids; D007773:Lactates; D010636:Phenols; D011422:Propionates; D002245:Carbon Dioxide; D014443:Tyrosine