The effect of bretylium on endogenous and newly-synthesized noradrenaline in the microsomal fraction of rat heart.
Bretylium reduced the content of endogenous and newly-synthesized noradrenaline (NA) and also reduced the specific activity of NA in the microsomal fraction of rat heart. Bretylium also decreased the endogenous NA content of the microsomal subfraction which equilibrated in the 0.7 M sucrose region of a density gradient; it was without effect on the NA content of other subfractions.
D000818:Animals; D001949:Bretylium Compounds / Q000494:pharmacology*; D002499:Centrifugation, Density Gradient; D004298:Dopamine / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008854:Microscopy, Electron; D008861:Microsomes / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism* / Q000648:ultrastructure; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013395:Sucrose; D014316:Tritium; D014443:Tyrosine / Q000378:metabolism
D001949:Bretylium Compounds; D011506:Proteins; D014316:Tritium; D014443:Tyrosine; D013395:Sucrose; D004298:Dopamine; D009638:Norepinephrine