[Changes in the terminal oxidation and active transport of calcium ions in the cerebral mitochondria of white rats following chronic cerebroside administration].
Terminal oxidation and active Ca ion transport have been studied in rat brain mitochondria following intraperitonial administrations of cerebrosides for 30 days. The results obtained have shown that cerebrosides inhibit terminal respiration at its 3rd metabolic state and reduce the rate of phosphorylation. ADP/O and ATP/t coefficients decrease due to the active transport of Ca ions. On increasing ADP and CaCl2 the time necessary for the binding and release of hydrogen ions is prolonged.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism*; D002554:Cerebrosides / Q000494:pharmacology*; D003864:Depression, Chemical; D008928:Mitochondria / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D002554:Cerebrosides; D002118:Calcium
Izmenenie terminal'nogo okisleniia i aktivnogo transporta ionov kal'tsiia v mitokhondriiakh mozga belykh krys pri khronicheskom vvedenii tserebrozidov.