Chemotherapy of experimental streptococcal endocarditis. II. Synergism between penicillin and streptomycin against penicillin-sensitive streptococci.
Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002509:Cephaloridine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000209:etiology; D004917:Erythromycin / Q000627:therapeutic use; D010400:Penicillin G / Q000627:therapeutic use; D010402:Penicillin G Procaine / Q000627:therapeutic use; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D011817:Rabbits; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy*; D013291:Streptococcus / Q000187:drug effects; D013307:Streptomycin / Q000627:therapeutic use*; D013552:Swine; D013752:Tetracycline / Q000627:therapeutic use; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D010406:Penicillins; D010402:Penicillin G Procaine; D004917:Erythromycin; D014640:Vancomycin; D013752:Tetracycline; D002509:Cephaloridine; D010400:Penicillin G; D013307:Streptomycin