Anomeric specificity of glucose-stimulated insulin release: evidence for a glucoreceptor?
The effects on insulin secretion of alpha and beta anomers of D-glucose were studied in the in vitro perfused rat pancreas. Both phases of insulin release showed consistent stereospecificity for alpha-glucose; this specificity indicates an action of glucose independent of intracellular glucose metabolism.
D000818:Animals; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D007328:Insulin; D011955:Receptors, Drug; D005947:Glucose