Pulsatile growth hormone secretion: suppression by hypothalamic ventromedial lesions and by long-acting somatostatin.
Sequential blood samples, obtained from freely behaving, nonstressed male rats, showed a pulsatile pattern of growth hormone secretion with a mean interval between peaks of 68 minutes. The bursts of secretion were blocked by lesions of the hypothalamic ventromedial nuclei and by administration of a longacting preparation of synthetic somatostatin.
D000818:Animals; D003345:Corticosterone / Q000097:blood; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000502:physiology*; D008297:Male; D051381:Rats; D013004:Somatostatin / Q000494:pharmacology*; D013997:Time Factors
D013004:Somatostatin; D013006:Growth Hormone; D003345:Corticosterone