Effect of DDS on phytohemagglutinin-induced lymphocyte transformation.
The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001755:Blastocyst / Q000032:analysis; D003622:Dapsone / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005006:Ethnicity; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D037102:Lectins / Q000008:administration & dosage*; D007918:Leprosy / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000032:analysis / Q000187:drug effects*; D008297:Male
D037102:Lectins; D003622:Dapsone