Cyclic metabolic pathway of a butylated hydroxytoluene by rat liver microsomal fractions.
A cyclic metabolic pathway was obtained when 3,5-di-t-butyl-4-hydroxytoluene (BHT) was incubated with a rat liver microsomal preparation. The pathway is as follows: BHT --> 4-hydroperoxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-OOH) --> 4-hydroxy-4-methyl-2,6-di-t-butylcyclohexa-2,5-dienone (BHT-3(0)OH) --> BHT. This metabolic pathway suggests that antioxidants such as BHT owe their high efficacy, at least in part, to their metabolic regeneration.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000378:metabolism*; D003408:Cresols / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D008956:Models, Chemical; D051381:Rats; D013997:Time Factors
D003408:Cresols; D002084:Butylated Hydroxytoluene