Fetal brain growth: selective action by growth hormone.
Growth hormone was administered to pregnant rats maintained under dietary control, and fetal and placental growth and nutrition were examined. Growth hormone had a selective action on brain growth that could not be attributed to nutrient mobilization but suggested a trophic factor which is unique to the brain.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D002250:Carbon Radioisotopes; D004247:DNA / Q000096:biosynthesis / Q000097:blood; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology*; D006128:Growth; D013006:Growth Hormone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008431:Maternal-Fetal Exchange; D009584:Nitrogen / Q000097:blood; D009747:Nutritional Physiological Phenomena; D009929:Organ Size; D009928:Organ Specificity; D010920:Placenta / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D001786:Blood Glucose; D001798:Blood Proteins; D002250:Carbon Radioisotopes; D007328:Insulin; D011506:Proteins; D013006:Growth Hormone; D004247:DNA; D009584:Nitrogen; D013936:Thymidine