[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 1. Effect on gonadotropic function of the rat hypophysis].
The antigonadotrophic activity of the metallibure preparation TURISYNCHRON and its zinc complex SUISYNCHRON was investigated in rats by measuring inhibition of testicular growth, inhibition of ovulation and effect on the oestrous cycle. The zinc complex was less active in the ovulation inhibition test, in contrast to the testicular inhibition test, and this was attributed to its peculiar mode of absorption.
D000818:Animals; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006065:Gonadotropins, Pituitary / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008693:Methallibure / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship; D013737:Testis / Q000187:drug effects / Q000254:growth & development; D013890:Thiourea / Q000378:metabolism; D014626:Vaginal Smears; D015032:Zinc / Q000494:pharmacology
D006065:Gonadotropins, Pituitary; D013890:Thiourea; D015032:Zinc; D008693:Methallibure
Pharmakologisch-endokrinologische Befunde bie der Prüfung von TURISYNCHRON und SUISYNCHRON im Tierexperiment