Effect of temperature on changes, induced by oestrus, in alpha- and beta-adrenoceptor activities of the rat uterus.
The alpha- and beta-adrenoceptor activities of the isolated rat uterus during the oestrous cycle were intluenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25 degrees C from 40 degrees C increased two-fold the inhibition produced by (-)-adrenaline, (-)-noradrenaline, (-)-phenylephrine and (-)-isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40 degrees C and isoprenaline produced only inhibition. At 25 degrees C the contractile alpha-responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory beta-effects of all four amines were increased.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D004971:Estrus; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011941:Receptors, Adrenergic; D013696:Temperature; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D011941:Receptors, Adrenergic; D010656:Phenylephrine; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine