Decreased cardiac toxicity of adriamycin and daunorubicin when bound to DNA.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004247:DNA / Q000008:administration & dosage / Q000494:pharmacology*; D003630:Daunorubicin / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004339:Drug Compounding; D004347:Drug Interactions; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006327:Heart Block / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D051381:Rats; D013997:Time Factors
D004317:Doxorubicin; D004247:DNA; D003630:Daunorubicin