[O and C prenylated chalcones with antineoplastic and antibiotic activities isolated from Lonchocarpus neuroscapha Benth].
In the course of our program on the antimicrobial and antineoplastic substances from higher plants we have studied many flavonoid compounds isolated from root back of Lonchocarpus neuroscapha Benth. In the present paper a slight effect on sarcoma 180 and Ehrlich carcinoma of cordoin, 4-hydroxy-cordoin and 4-hydroxy-derricin, as well as the only observed effect of derricin on sarcoma 180 were observed. The antimicrobial action of four prenylated chalcones, i.e. 4-hydroxy-derricin, 4-hydroxy-lonchocarpin, 4-hydroxy-cordoin and 4-hydroxy-isocordoin is reported.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002599:Chalcone / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts; D011427:Propiophenones / Q000302:isolation & purification*; D012510:Sarcoma 180 / Q000188:drug therapy
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011427:Propiophenones; D002599:Chalcone
Chalconas o- ec-preniladas com atividades antibiótica e antineoplásica, isoladas de Lonchocarpus neuroscapha Benth