The possible role of cytochrome P-450 in the liver "first pass elimination" of a beta-receptor blocking drug.
D000284:Administration, Oral; D000526:Alprenolol / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001682:Biological Availability; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003864:Depression, Chemical; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism*; D008297:Male; D008722:Methods; D008797:Metyrapone / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010477:Perfusion; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D013053:Spectrophotometry; D013997:Time Factors; D014316:Tritium
D065607:Cytochrome P-450 Enzyme Inhibitors; D014316:Tritium; D000526:Alprenolol; D003577:Cytochrome P-450 Enzyme System; D011335:Proadifen; D007099:Imipramine; D010634:Phenobarbital; D008797:Metyrapone