Tentative method for the qualitative detection and quantitative assessment of air contamination by drugs.
A method for detecting and measuring air contamination by drugs is described which uses an electrostatic bacterial air sampler, sprayers for micronizing drugs, and Mueller-Hinton medium seeded with a highly susceptible strain of Sarcina lutea. Three antibiotics (penicillin, tetracycline, aminosidine) and a sulfonamide (sulfapyrazine) were identified by pretreating portions of medium, showing no bacterial growth, with penicillinase or p-aminobenzoic acid solution and subsequently determining how both drug(-) susceptible and drug-resistant strains of Staphylococcus aureus were affected by this pretreatment. Quantitative determinations were also attempted by measuring the size of the inhibition zones.
D000388:Air / Q000032:analysis*; D000397:Air Pollution; D062365:Aminobenzoates / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D001681:Biological Assay; D004339:Drug Compounding; D004560:Electricity; D008280:Magnetics; D008722:Methods; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010405:Penicillinase / Q000494:pharmacology; D010406:Penicillins / Q000032:analysis / Q000494:pharmacology; D012505:Sarcina / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013449:Sulfonamides / Q000032:analysis / Q000494:pharmacology; D013752:Tetracycline / Q000032:analysis / Q000494:pharmacology
D062365:Aminobenzoates; D000900:Anti-Bacterial Agents; D010406:Penicillins; D013449:Sulfonamides; D010405:Penicillinase; D013752:Tetracycline