Urinary excretion of diphenylhydantoin metabolites in newborn infants.
The plasma half-life of diphenylhydantoin newborn infants of epileptic mothers, treated with this drug, is in the same range as the plasma half-life in adults. The urinary excretion of diphenylydantoin and its main metabolites has been investigated in six newborn infants. The results show that the rapid plasma disappearance of diphenylhydantoin is due to rapid metabolism of the drug.
D002849:Chromatography, Gas; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010672:Phenytoin / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use / Q000652:urine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy
D010672:Phenytoin