Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 2: in vivo parenteral pharmacology and acute toxicity in mice. Comparison with morphine, codeine and diphenoxylate.
D000577:Amides / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002606:Charcoal / Q000008:administration & dosage; D002722:Chlorobenzenes / Q000494:pharmacology / Q000633:toxicity; D003061:Codeine / Q000494:pharmacology* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007540:Isonipecotic Acids / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology* / Q000633:toxicity; D009043:Motor Activity / Q000187:drug effects; D009570:Nitriles / Q000494:pharmacology / Q000633:toxicity; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity
D000577:Amides; D000930:Antidiarrheals; D002722:Chlorobenzenes; D005765:Gastrointestinal Agents; D007540:Isonipecotic Acids; D009570:Nitriles; D010880:Piperidines; D002606:Charcoal; D009020:Morphine; D003061:Codeine