Neonatal hyperthyroidism and long-acting thyroid stimulator protector.
Neonatal hyperthyroidism has been thought to result from transplacental passage of long-acting thyroid stimulator (L.A.T.S.) from a mother with Graves's disease. A case is presented here in which no L.A.T.S. was detected in the mother or neonate but another immunoglobulin, L.A.T.S. protector, a specific human thyroid stimulator, was shown to be present in the mother's serum. This stimulator may have been the cause of the neonatal hyperthyroidism.
D000328:Adult; D001681:Biological Assay; D005260:Female; D006111:Graves Disease / Q000150:complications; D006801:Humans; D006980:Hyperthyroidism / Q000151:congenital*; D007231:Infant, Newborn; D008135:Long-Acting Thyroid Stimulator / Q000502:physiology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011863:Radioimmunoassay; D013960:Thyroid Function Tests; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood
D013972:Thyrotropin; D008135:Long-Acting Thyroid Stimulator