Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain.
1 Benzoctamine, a new psychoactive drug, known to exert in man an anti-anxiety effect resembling that of chlordiazepoxide, decreased the disappearance of intraventricularly-injected [(14)C]-5-hydroxytryptamine (5-HT) from rat brain, as did chlordiazepoxide.2 Both drugs partially inhibited the alpha-ethyl-3-hydroxy-4-methylphenylethylamine-induced depletion of rat brain 5-HT.3 It is concluded that benzoctamine, like chlordiazepoxide, decreases 5-HT turnover in the brain and that this action may play a role in the anti-anxiety effect of these drugs observed in man.
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists
D000873:Anthracenes; D010627:Phenethylamines; D012702:Serotonin Antagonists; D012701:Serotonin; D002707:Chlordiazepoxide