Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.
D000284:Administration, Oral; D000577:Amides / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology* / Q000633:toxicity; D002368:Castor Oil / Q000494:pharmacology; D002722:Chlorobenzenes / Q000494:pharmacology / Q000633:toxicity; D003061:Codeine / Q000494:pharmacology* / Q000633:toxicity; D003967:Diarrhea / Q000188:drug therapy; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006168:Guinea Pigs; D007540:Isonipecotic Acids / Q000494:pharmacology* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology* / Q000633:toxicity; D009570:Nitriles / Q000494:pharmacology / Q000633:toxicity; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013997:Time Factors
D000577:Amides; D000930:Antidiarrheals; D002722:Chlorobenzenes; D005765:Gastrointestinal Agents; D007540:Isonipecotic Acids; D009570:Nitriles; D010880:Piperidines; D009020:Morphine; D002368:Castor Oil; D003061:Codeine