[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHROM. 2. Toxicologic findings].
Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001835:Body Weight; D002746:Chlorpromazine / Q000494:pharmacology; D002908:Chronic Disease; D004378:Duodenal Diseases; D005260:Female; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008431:Maternal-Fetal Exchange; D008693:Methallibure / Q000008:administration & dosage / Q000633:toxicity; D051379:Mice; D009929:Organ Size; D010208:Papaverine / Q000494:pharmacology; D010437:Peptic Ulcer / Q000139:chemically induced; D011041:Poisoning / Q000097:blood; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives*; D015032:Zinc
D001285:Atropine; D010208:Papaverine; D013890:Thiourea; D015032:Zinc; D008693:Methallibure; D002746:Chlorpromazine
Pharmakologisch-endokrinologische Befunde bei der Prüfung von TURISYNCHRON) und SUISYNCHRON) im Tierexperiment. 2. Mitteilung: Toxikologische Befunde