Acetylcholine noise: analysis after chemical modification of receptor.
The elementary voltage pulses ("shot effects") produced by the action of acetylcholine molecules on the receptor were studied by analyzing the membrane voltage fluctuations ("noise") after acetylcholine application at the frog neuromuscular junction. The amplitude of these pulses was decreased after treatment with a disulfide-bond reducing agent. The shot effect may thus depend on the structure or conformation of the receptor molecule.
D000109:Acetylcholine / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001001:Anura; D004228:Dithionitrobenzoic Acid / Q000494:pharmacology; D004229:Dithiothreitol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010539:Permeability; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014403:Tubocurarine / Q000494:pharmacology
D011950:Receptors, Cholinergic; D004228:Dithionitrobenzoic Acid; D000109:Acetylcholine; D004229:Dithiothreitol; D014403:Tubocurarine