Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 4: studies on subacute and chronic toxicity and the effect on reproductive processes in rats, dogs and rabbits.
D000284:Administration, Oral; D000577:Amides / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D000831:Animals, Newborn; D000930:Antidiarrheals / Q000008:administration & dosage / Q000633:toxicity*; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D002722:Chlorobenzenes / Q000008:administration & dosage / Q000633:toxicity; D003404:Creatinine / Q000652:urine; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects; D005765:Gastrointestinal Agents / Q000633:toxicity*; D008297:Male; D009929:Organ Size; D010880:Piperidines / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats
D000577:Amides; D000930:Antidiarrheals; D002722:Chlorobenzenes; D005765:Gastrointestinal Agents; D010880:Piperidines; D003404:Creatinine