Penetration of cells by asbestos fibers.
Studies on the behavior of asbestos fibers within tissues have shown that the only cells that regularly contain asbestos are macrophages and their derivatives. However, these cells actively incorporate the asbestos fibers by the process of phagocytosis, and there is little evidence of direct penetration. Examination of the gut lining after prolonged asbestos ingestion has shown no evidence of dust penetration either through or between the epithelial cells. The structure and arrangement of these cells is discussed, and it is suggested that they are exceptionally well adapted to prevent penetration by any solid material.
D000818:Animals; D001194:Asbestos / Q000378:metabolism*; D002462:Cell Membrane / Q000648:ultrastructure; D003896:Desmosomes / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000648:ultrastructure; D006168:Guinea Pigs; D007413:Intestinal Mucosa / Q000378:metabolism / Q000648:ultrastructure; D007421:Intestine, Small / Q000378:metabolism / Q000648:ultrastructure; D008168:Lung; D008264:Macrophages; D051379:Mice; D010587:Phagocytosis; D051381:Rats
D001194:Asbestos