Ethanol inhibition of vitamin A metabolism in the testes: possible mechanism for sterility in alcoholics.
Vitanin A (retinol) is essential for spermatogenesis. Alcohol dehydrogenase, the enzyme responsible for ethanol metabolism, is also required for the conversion of retinol to bioactive retinal at the end organ site. Ethanol inhibits the oxidation of retinol by testicular homogenates containing alcohol dehydrogenase. Thus, a possible biochemnical mechanism for the sterility of chronic alcoholics is identified.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001001:Anura / Q000254:growth & development; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D051381:Rats; D012172:Retinaldehyde / Q000378:metabolism; D013737:Testis / Q000201:enzymology / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism*
D014801:Vitamin A; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D012172:Retinaldehyde