A study of various changes in transfer ribonucleic acid methylase activity during adenovirus-12 transformation in vitro.
A number of parameters were used to correlate a change in control or expression of tRNA methylase activity and the transformation by adenovirus-12 in vitro. The earliest change observed corresponding to visible morphological changes was a decrease in the tRNA methylase inhibitor(s).
D000256:Adenoviridae / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002854:Chromatography, Paper; D003168:Complement Fixation Tests; D005849:Gerbillinae; D006868:Hydrolysis; D066298:In Vitro Techniques; D007668:Kidney; D008168:Lung; D012359:tRNA Methyltransferases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D012359:tRNA Methyltransferases