[Clinical and experimental studies on the fate of chondrotin s-lfuric iron during developing hepatic fibrosis (author's transl)].
Derangements in iron metabolism following liver damage were studied with special reference to iron deposit in relation to reticuloendothelial functions. In clinical studies, the metabolic fate of chondroitin sulfuric 59Fe, given intravenously, was examined in patients with chronic hepatitis or liver cirrhosis, diagnosed by liver biopsy. In experimental studies, liver damage was induced in rats by carbon tetrachloride (CCl4) injection and the labeled iron was similarly administered. 1) In patients with chronic hepatitis or liver cirrhosis, a reduction in uptake and utilization rates of the labeled iron was observed. 2) In rats with CCl4-induced liver damage, these parameters of the reticuloendothelial function were more reduced in parallel with the extent of hepatic fibrosis. 3) Similar conclusion was obtained from the analysis of iron distribution among tissues and of iron incorporation into several fractions of the liver: that is the uptake into non-hemin iron was less as the fibrosis advanced. In addition, more iron was incorporated into hemosiderin fraction and less into ferritin fraction. The findings may suggest a derangement in apoferritin synthesis as well as in release mechanism of deposit iron. 4) It is suggested that derangements in iron metabolism following liver damage are mainly due to reduction of the reticuloendothelial functions, but are partly due to changes in hematopoiesis and protein metabolism.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000378:metabolism*; D002908:Chronic Disease; D006505:Hepatitis / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008297:Male; D012157:Mononuclear Phagocyte System / Q000378:metabolism; D051381:Rats
D002807:Chondroitin; D002809:Chondroitin Sulfates; D007501:Iron