Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice.
Single toxic doses of 1,2-dimethylhydrazine induced mild centrilobular necrosis of the liver in rats and mice. Ultrastructural studies showed hepatic nuclear changes including nucleolar microsegregation and changes in the endoplasmic reticulum and mitochondria. 1-Methylhydrazine caused little morphological change in the liver. Tumours of the colon and kidney and also massive cystic hyperplasia of the liver were found in some of the rats and tumours of the anal margin and kidney in some of the mice, following single doses of 1,2-dimethylhydrazine. Incorporation of amino acids into rat liver proteins was inhibited by 1,2-dimethylhydrazine, which also caused disaggregation of hepatic polysomes. No effects on hepatic protein synthesis by 1,1-dimethylhydrazine or 1-methylhydrazine were observed. Similarities between the effects of 1,2-dimethylhydrazine, cycasin and dimethylnitrosamine are discussed.
D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced; D004127:Dimethylhydrazines / Q000494:pharmacology* / Q000633:toxicity; D004721:Endoplasmic Reticulum / Q000187:drug effects; D006834:Hydrazines / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000139:chemically induced; D007928:Lethal Dose 50; D007930:Leucine / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D009002:Monomethylhydrazine / Q000494:pharmacology / Q000633:toxicity; D009369:Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012270:Ribosomes / Q000032:analysis / Q000187:drug effects
D004127:Dimethylhydrazines; D006834:Hydrazines; D007930:Leucine; D009002:Monomethylhydrazine