Covalent binding of drugs to tissue macromolecules as a biochemical mechanism of drug toxicities with special emphasis on chloramphenicol and thiamphenicol.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002701:Chloramphenicol / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008862:Microsomes, Liver / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011955:Receptors, Drug; D013839:Thiamphenicol / Q000378:metabolism* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D011955:Receptors, Drug; D002701:Chloramphenicol; D013839:Thiamphenicol