The effect of receptor desensitization on the action of alpha-bungaro-toxin on cultured skeletal muscle.
The effect of receptor desensitization produced by carbachol on the antagonist action of alpha-bungarotoxin has been studied in cultured skeletal muscle from chick embryos. In control preparations, alpha-bungarotoxin irreversibly blocked depolarization produced by carbachol. However, after receptor desensitization, alpha-bungarotoxin was no longer effective in blocking the response to carbachol. It is concluded that desensitization protects cholinoceptors from the action of alpha-bungarotoxin.
D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D002642:Chick Embryo; D046508:Culture Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D011950:Receptors, Cholinergic; D011955:Receptors, Drug; D013997:Time Factors
D002038:Bungarotoxins; D009467:Neuromuscular Depolarizing Agents; D011950:Receptors, Cholinergic; D011955:Receptors, Drug; D002217:Carbachol