Mitogenic activity of sterculic acid, a cyclopropenoid fatty acid.
Hepatocytes in rainbow trout and rat are stimulated to augmented DNA synthesis and cell division by low concentrations of cyclopropenoid fatty acids in the diet. Sterculic acid isolated as the methyl ester from Sterculia foetida oil has been identified as one of the mitogenic principles.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003521:Cyclopropanes / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004041:Dietary Fats / Q000009:adverse effects*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D008934:Mitogens; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D014337:Trout
D003521:Cyclopropanes; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008934:Mitogens; D004247:DNA