Skin carcinogenesis: cholesterol-5alpha,6alpha-epoxide hydrase activity in mouse skin irradiated with ultraviolet light.
Cholesterol-5alpha,6alpha-epoxide hydrase activity was 96 percent greater in skin of hairless mice that were receiving suberythemic ultraviolet light irradiation for 15 weeks than in nonirradiated controls. This enzyme system, which metabolizes cholesterol-5alpha,6alpha-epoxide (a known carcinogen), appears to be substrateinducible and is apparently responsible for the concomitant reduction of the sterol carcinogen that occurs prior to tumor induction.
D000818:Animals; D002273:Carcinogens; D002784:Cholesterol; D004790:Enzyme Induction; D004852:Epoxy Compounds; D006801:Humans; D006836:Hydro-Lyases / Q000528:radiation effects*; D051379:Mice; D009381:Neoplasms, Radiation-Induced; D011830:Radiation Effects; D012867:Skin / Q000201:enzymology*; D012878:Skin Neoplasms / Q000201:enzymology; D014466:Ultraviolet Rays
D002273:Carcinogens; D004852:Epoxy Compounds; D002784:Cholesterol; D006836:Hydro-Lyases