title: Complete left ventricular bypass with a paracorporeal pump: design and evaluation.
abstract: A multidiscipline group was established at The Pennsylvania State University to design and evaluate mechanical circulatory assist devices and the artificial heart. The group has designed a left ventricular to aortic assist system which consists of a sac-type pump, a synchronization unit, a pneumatic power unit, and appropriate monitoring apparatus. The assist system has been evaluated for long-term circulatory assistance in a series of ten calves. The assist pump was placed in the paracorporeal position. The longest period of continuous pumping was over eight months. The last four calves have had synchronized assist pumping which has permitted prolonged ventricular decompression and assist pump flow rates as high as 10 L/min. Three of these four calves had no evidence of thromboemboli. Additional animal studies will be required before clinical use of such an assist pump system can be safely undertaken.
mesh_terms: D000818:Animals; D001243:Assisted Circulation / Q000295:instrumentation*; D001772:Blood Cell Count; D001783:Blood Flow Velocity; D001792:Blood Platelets; D002417:Cattle; D001026:Coronary Artery Bypass / Q000295:instrumentation*; D005069:Evaluation Studies as Topic; D006352:Heart Ventricles / Q000098:blood supply; D006355:Heart-Lung Machine / Q000295:instrumentation*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D013923:Thromboembolism; D013997:Time Factors
chemical_list: D006454:Hemoglobins