Simultaneous administration of smallpox, measles, yellow fever, and diphtheria-pertussis-tetanus antigens to Nigerian children.
Children receiving smallpox, measles, and yellow fever vaccines simultaneously at separate sites responded adequately to all three vaccines. In those children, 9 months of age and older, who received these three vaccines in addition to diphtheria-pertussis-tetanus vaccine, there was a decrease in measles seroconversion rates from 89% to 70%. Possible interactions between live and killed vaccines should be considered when the administration of multiple antigens is planned.
D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D008457:Measles / Q000276:immunology; D008458:Measles Vaccine / Q000008:administration & dosage*; D009549:Nigeria; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D012899:Smallpox / Q000276:immunology; D012900:Smallpox Vaccine / Q000008:administration & dosage*; D013742:Tetanus / Q000276:immunology; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D013997:Time Factors; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage*; D014917:Whooping Cough / Q000276:immunology; D015004:Yellow Fever / Q000276:immunology; D015005:Yellow fever virus / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D004168:Diphtheria Toxoid; D008458:Measles Vaccine; D010567:Pertussis Vaccine; D012900:Smallpox Vaccine; D013745:Tetanus Toxoid; D014765:Viral Vaccines