title: Sequences present in both human leukemic cell nuclear DNA and Rauscher leukemia virus.
abstract: DNA synthesized by particulate fractions from human leukemic white blood cells has been subfractionated by hybridization to Rauscher leukemia virus 70S RNA followed by hydroxylapatite chromatography. The Rauscher-leukemia-virus-specific DNA fraction is shown to be complementary only to sequences present in the nuclear DNA of Balb/c mouse spleens infected by this virus and the nuclear DNA from human leukemic white blood cells, and not to sequences present in the nuclear DNA of normal Balb/c mouse spleens or the nuclear DNA of normal human white blood cells.
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002499:Centrifugation, Density Gradient; D002845:Chromatography; D004273:DNA, Neoplasm / Q000378:metabolism*; D004279:DNA, Viral / Q000378:metabolism*; D005816:Genetic Complementation Test; D006801:Humans; D007938:Leukemia / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009693:Nucleic Acid Hybridization; D011925:Rauscher Virus / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D004279:DNA, Viral