7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology; D007945:Leukemia, Lymphoid / Q000201:enzymology; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000201:enzymology; D008727:Methotrexate / Q000627:therapeutic use; D051379:Mice; D010084:Oxidation-Reduction; D011087:Polycythemia Vera / Q000097:blood / Q000188:drug therapy / Q000201:enzymology; D013154:Spleen / Q000201:enzymology; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000097:blood / Q000378:metabolism*
D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate