Uncomplicated HL-A matched sibling bone marrow graft for combined immune deficiency.
When an apparently identical HL-A donor can be found and satisfactorily checked by the mixed lymphocyte reaction, it is worth attempting simple bone marrow grafting in a patient with combined immune deficiency syndrome who otherwise would die. Immunocompetence was given in this way to a baby girl by her 4-year-old brother and was confirmed by the presence of Y-chromosome in most of the transforming lymphocytes. IgA was late to emerge, presumably owing to the immaturity for IgA of the donor's bone marrow.
D016026:Bone Marrow Transplantation; D005260:Female; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007153:Immunologic Deficiency Syndromes / Q000601:surgery*; D007223:Infant; D007519:Isoantigens; D007621:Karyotyping; D008213:Lymphocyte Activation; D008214:Lymphocytes; D012730:Sex Chromosomes; D014184:Transplantation, Homologous
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007519:Isoantigens