title: Microtubule function in immune and nonimmune lymphocyte-mediated cytotoxicity.
abstract: Disaggregation of microtubular subunits in effector lymphocytes inhibits their ability to injure target cells. The inhibition is not reversed by denterium oxide, an agent known to stablize microtubular subunits.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D002859:Chromium Isotopes; D003078:Colchicine / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D003903:Deuterium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008870:Microtubules / Q000187:drug effects / Q000502:physiology*; D010087:Oxides / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D002859:Chromium Isotopes; D010087:Oxides; D014747:Vinblastine; D003903:Deuterium; D003078:Colchicine