Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species.
The ability of fibroblasts to perform unscheduled DNA synthesis (a measure of excision-repair) after UV irradiation was measured radioautographically for seven species at several times after several UV fluences. Both the initial rate and the maximum incorporation of [(3)H]dThd increased with the life-span of the species (shrew, mouse, rat, hamster, cow, elephant, man). Unscheduled DNA synthesis was approximately proportional to the logarithm of life-span.
D000375:Aging; D000818:Animals; D001345:Autoradiography; D002417:Cattle; D006224:Cricetinae; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004260:DNA Repair; D004606:Elephants; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D008136:Longevity; D008297:Male; D008322:Mammals; D051379:Mice; D011830:Radiation Effects; D051381:Rats; D012788:Shrews; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014466:Ultraviolet Rays
D014316:Tritium; D004247:DNA; D013936:Thymidine