Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect.
The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN =/> AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000942:Antigens, Bacterial; D002352:Carrier Proteins; D004140:Dinitrophenols / Q000494:pharmacology; D005260:Female; D005407:Flagella / Q000276:immunology; D006241:Haptens; D006386:Hemagglutination Tests; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007114:Immunization; D051381:Rats; D012475:Salmonella / Q000276:immunology; D012710:Serum Albumin, Bovine; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D002352:Carrier Proteins; D004140:Dinitrophenols; D006241:Haptens; D012710:Serum Albumin, Bovine