Control of growth of a tumor cell by linoleic acid.
The growth of mouse myeloma XS 63.5 cells in cell culture is dependent on serum. Among the several growth factors present in serum, the lipid fraction is highly active. The growth factor(s) provided by the serum lipid fraction can be replaced by unsaturated fatty acids. If XS 63.5 cells are cultured in medium that is low in serum lipids, the cells become quiescent, with most of the cells in the G(1) (or G(0)) phase of the cell cycle. Addition of linoleic acid to such quiescent cells leads to reinitiation of DNA synthesis and growth.
D000818:Animals; D001769:Blood; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003470:Culture Media; D004273:DNA, Neoplasm / Q000032:analysis / Q000096:biosynthesis; D005470:Fluorometry; D006133:Growth Substances; D008041:Linoleic Acids / Q000494:pharmacology*; D008055:Lipids; D051379:Mice; D009101:Multiple Myeloma / Q000378:metabolism; D009374:Neoplasms, Experimental
D003470:Culture Media; D004273:DNA, Neoplasm; D006133:Growth Substances; D008041:Linoleic Acids; D008055:Lipids