title: Poliomyelitis in Japan during the period 1962-68 after the introduction of mass vaccination with Sabin vaccine.
abstract: After the mass vaccination of children of susceptible age groups in Japan in 1961, the incidence of poliomyelitis decreased markedly. From 1962 to 1968 a total of 659 paralytic cases were officially notified. Detailed investigations of 626 cases reported to the Poliomyelitis Surveillance Committee revealed that only 185 (29.6%) were cases of paralysis clinically typical of poliomyelitis. Tests on 120 of these 185 cases showed that 75 (62.5%) were positive for poliovirus: 45 of these positive cases were temporally associated with the administration of live poliovirus vaccine and 36 had some residual disability. Wild types of poliovirus were rarely isolated. Only 36 vaccine-related cases of poliomyelitis were observed among the total of more than 11 million newborn infants vaccinated with Sabin vaccine in the period 1962-68.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral; D014611:Vaccination
chemical_list: D011055:Poliovirus Vaccine, Oral