title: Isoleucine accumulation by regulatory mutants of Serratia marcescens: lack of both feedback inhibition and repression.
abstract: Double mutants of Serratia marcescens resistant to isoleucine hydroxamate and alpha-aminobutyric acid accumulated large amounts of isoleucine in a salts-sugar medium and lacked both feedback inhibition and repression of the isoleucine biosynthesis.
mesh_terms: D000613:Aminobutyrates / Q000494:pharmacology; D003470:Culture Media; D004352:Drug Resistance, Microbial; D004794:Enzyme Repression; D005246:Feedback; D005827:Genetics, Microbial; D006836:Hydro-Lyases / Q000378:metabolism; D006877:Hydroxamic Acids / Q000494:pharmacology; D007532:Isoleucine / Q000096:biosynthesis* / Q000494:pharmacology; D008190:Lyases / Q000378:metabolism; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D013237:Stereoisomerism; D013912:Threonine / Q000378:metabolism / Q000494:pharmacology; D000637:Transaminases / Q000378:metabolism
chemical_list: D000613:Aminobutyrates; D003470:Culture Media; D006877:Hydroxamic Acids; D009153:Mutagens; D009604:Nitrosoguanidines; D007532:Isoleucine; D013912:Threonine; D000637:Transaminases; D008190:Lyases; D006836:Hydro-Lyases