Cytochalasin B: does it affect actin-like filaments?
An in vitro system was used to test the purported action of cytochalasin B. At concentrations 100 times those used for experiments in vivo, cytochalasin B did not cause the breakdown of F-actin, did not inhibit the transformation of G-actin to F-actin, did not inhibit the binding of heavy meromyosin to F-actin, and did not inhibit the adenosine triphosphate-induced release of heavy meromyosin from F-actin.
D000199:Actins / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D009124:Muscle Proteins / Q000378:metabolism*; D009183:Mycotoxins / Q000494:pharmacology*; D009210:Myofibrils / Q000187:drug effects*; D015879:Myosin Subfragments / Q000378:metabolism; D011108:Polymers; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits
D000199:Actins; D009124:Muscle Proteins; D009183:Mycotoxins; D015879:Myosin Subfragments; D011108:Polymers; D000255:Adenosine Triphosphate