Virus-free adenocarcinoma of the frog (summer phase tumor) transcribes Lucké tumor herpesvirus-specific RNA.
[(3)H]RNA isolated from "virus-free," summer phase, renal adenocarcinomas of Rana pipiens labeled with [(3)H]uridine hybridizes with DNA of herpesvirus particles isolated from the winter phase Lucké tumor. Transcription of the herpesvirus genome in virus-free tumors provides additional evidence for the viral etiology of this tumor.
D000230:Adenocarcinoma / Q000382:microbiology*; D000818:Animals; D001001:Anura; D002499:Centrifugation, Density Gradient; D004279:DNA, Viral / Q000302:isolation & purification / Q000378:metabolism; D006564:Herpesviridae / Q000032:analysis; D007674:Kidney Diseases / Q000382:microbiology*; D009374:Neoplasms, Experimental / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000302:isolation & purification* / Q000378:metabolism; D011894:Rana pipiens; D014316:Tritium
D004279:DNA, Viral; D012367:RNA, Viral; D014316:Tritium