Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
D000818:Animals; D001681:Biological Assay; D002452:Cell Count; D002460:Cell Line; D002478:Cells, Cultured / Q000187:drug effects*; D003839:Deoxyadenosines / Q000494:pharmacology; D003854:Deoxyribonucleotides / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005492:Folic Acid / Q000378:metabolism*; D006801:Humans; D007739:L Cells / Q000378:metabolism; D007939:Leukemia L1210 / Q000201:enzymology / Q000378:metabolism; D008223:Lymphoma / Q000201:enzymology / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology*; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism; D051379:Mice; D051381:Rats; D012517:Sarcoma, Yoshida / Q000201:enzymology / Q000378:metabolism; D013936:Thymidine / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000378:metabolism
D003839:Deoxyadenosines; D003854:Deoxyribonucleotides; D005492:Folic Acid; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D013940:Thymidylate Synthase; D013936:Thymidine; D008727:Methotrexate