Evidence that methadone blocks dopamine receptors in the brain.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D002090:Butyrophenones / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced; D008691:Methadone / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology; D010648:Phenylacetates / Q000378:metabolism; D051381:Rats; D011984:Sensory Receptor Cells / Q000187:drug effects*; D014316:Tritium; D014443:Tyrosine / Q000378:metabolism
D002090:Butyrophenones; D010640:Phenothiazines; D010648:Phenylacetates; D014316:Tritium; D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan; D001058:Apomorphine; D008691:Methadone; D004298:Dopamine; D009638:Norepinephrine