Degradation of human alpha 1-antitrypsin by hepatocyte acid cathepsins. Possible role in clinical alpha 1-antitrypsin deficiency.
D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D001673:Biodegradation, Environmental; D002403:Cathepsins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002951:Citrates; D005978:Glutathione; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007122:Immunoelectrophoresis; D008099:Liver / Q000166:cytology* / Q000201:enzymology; D008110:Liver Extracts; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology; D011656:Pulmonary Emphysema / Q000209:etiology; D011817:Rabbits; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000378:metabolism; D019896:alpha 1-Antitrypsin Deficiency
D002951:Citrates; D008110:Liver Extracts; D000515:alpha 1-Antitrypsin; D002403:Cathepsins; D005978:Glutathione