Clonal memory. I. Time-course of proliferation of B-memory cells.
A single clone of B cells producing anti-DNP antibody recognizable by the isoelectric-focusing spectrum has been used, in a double transfer system, to study clonal memory. Trasnsferable B memory develops between 4 and 7 days after the first transfer with antigen. B-memory cells thus proliferate before or concomitantly with antibody-forming cells.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens; D001345:Autoradiography; D001402:B-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D002999:Clone Cells / Q000276:immunology*; D004140:Dinitrophenols; D005260:Female; D007116:Immunization, Passive; D007156:Immunologic Memory; D007457:Iodine Radioisotopes; D007525:Isoelectric Focusing; D007700:Kinetics; D051379:Mice; D008808:Mice, Inbred CBA; D011828:Radiation Chimera
D000906:Antibodies; D000941:Antigens; D004140:Dinitrophenols; D007457:Iodine Radioisotopes