title: On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
abstract: Simultaneous immunological titration of DOPA and 5-hydroxytryptophan decarboxylase activities, from a number of tissues of various species, showed that the two activities were not distinguishable with a monospecific antiserum to hog kidney decarboxylase. Together with previous findings, these data firmly establish the concept that in mammalian tissues the two enzyme activities are associated with a single protein, namely aromatic L-amino acid decarboxylase.
mesh_terms: D006916:5-Hydroxytryptophan; D000818:Animals; D001921:Brain / Q000201:enzymology; D002262:Carboxy-Lyases / Q000378:metabolism*; D003653:Decarboxylation; D004296:Dopa Decarboxylase / Q000378:metabolism*; D005260:Female; D006041:Goats; D007106:Immune Sera; D007120:Immunochemistry; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D010870:Pineal Gland / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013045:Species Specificity; D013552:Swine; D013997:Time Factors
chemical_list: D007106:Immune Sera; D006916:5-Hydroxytryptophan; D002262:Carboxy-Lyases; D004296:Dopa Decarboxylase