title: Solutions to the cost-of-selection dilemma.
abstract: There are various biologically realistic ways around the cost-of-selection restriction on rapid multiple-gene substitution. Some of these ways depend upon particular forms of interaction or linkage in the genes undergoing substitution; other ways depend on particular conditions of population size and structure. The special genotypic and populational conditions required for rapid evolutionary change in genetically complex characters are not unusual in higher organisms.
mesh_terms: D000483:Alleles; D005075:Biological Evolution; D005787:Gene Frequency; D008040:Genetic Linkage; D005828:Genetics, Population; D008954:Models, Biological; D011110:Polymorphism, Genetic; D012641:Selection, Genetic