title: Dissociation of the behavioural and endocrine effects of lysine vasopressin by tryptic digestion.
abstract: 1. Lysine vasopressin induces resistance to extinction of active avoidance behaviour (De Wied, 1971).2. Digestion of lysine vasopressin with trypsin almost completely destroys the pressor-, antidiuretic-, oxytocic- and corticotrophin-releasing factor activities of lysine vasopressin, but does not materially influence its effect on the maintenance of an avoidance response.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001681:Biological Assay; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D008239:Lysine; D008297:Male; D051381:Rats; D014357:Trypsin; D014599:Uterus / Q000187:drug effects; D014667:Vasopressins
chemical_list: D014667:Vasopressins; D003346:Corticotropin-Releasing Hormone; D014357:Trypsin; D008239:Lysine