Hydrostatic pressure effects on Escherichia coli: site of inhibition of protein synthesis.
Utilizing whole-cell preparations of Escherichia coli, it appears that 670 atm inhibits protein synthesis during elongation, while not affecting aminoacyl transfer ribonucleic acid formation, polysomal integrity, or amino acid permeability.
D000596:Amino Acids / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis*; D001665:Binding Sites; D002247:Carbon Isotopes; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D010452:Peptide Biosynthesis; D010649:Phenylalanine / Q000378:metabolism; D011312:Pressure; D012329:RNA, Bacterial / Q000096:biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000096:biosynthesis; D012270:Ribosomes / Q000378:metabolism
D000596:Amino Acids; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D012329:RNA, Bacterial; D012333:RNA, Messenger; D010649:Phenylalanine; D012343:RNA, Transfer; D007930:Leucine