Reactions and serologic responses to monovalent acetone-inactivated typhoid vaccine and heat-killed TAB when given by jet injection.
Monovalent acetone-inactivated typhoid vaccine and heat-killed TAB caused local reactions in 82-88% of volunteers vaccinated by jet injection, whereas they caused local reactions in only 24% of volunteers injected by means of a conventional syringe. Both vaccines induced a high seroconversion rate to typhoid H antigen, but neither proved significantly immunogenic to antigens O and Vi. There was no increase in the occurrence of local reactions when a second jet injection was given 5 weeks after the first.
D000328:Adult; D000917:Antibody Formation; D006801:Humans; D007273:Injections, Intramuscular; D007277:Injections, Jet; D008297:Male; D014435:Typhoid Fever / Q000276:immunology* / Q000517:prevention & control; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage*; D014611:Vaccination / Q000009:adverse effects* / Q000379:methods; D014613:Vaccines, Attenuated / Q000008:administration & dosage*
D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated