Spironolactone and cytochrome P-450: impairment of steroid hydroxylation in the adrenal cortex.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006168:Guinea Pigs; D006900:Hydroxylation; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology*; D013256:Steroids / Q000378:metabolism*
D013256:Steroids; D013148:Spironolactone; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases