Genetic control of the immune response. The effect of thymectomy on the primary and secondary antibody response of mice to poly-L(tyr, glu)-poly-D, L-ala--poly-L-lys.
The effect of thymectomy on the genetically controlled murine immune response-1 (Ir-1) to the synthetic polypeptide poly-L(Tyr, Glu)-poly-D, L-Ala--poly-L-Lys [(T, G)-A--L] was studied with both aqueous and adjuvant immunization regimens. Adult thymectomy (combined with irradiation and bone marrow transfusion) did not affect the aqueous antigen-induced (IgM) primary response of either high or low responder mice, but did ablate the (IgG) secondary or tertiary response, a response which is restricted to the high responder strains. Adult thymectomy also blocked the normal high response to (T,G)-A--L in Freund's adjuvant in high responder mice and the high response to methylated bovine serum albumin (MBSA)-(T,G)-A--L in low responder mice. Neonatal thymectomy was also effective in blocking the response to (T, G)-A--L in Freund's adjuvant in high responder mice. These data are consistent with the concept that the Ir-1 gene effect is mediated via thymus cell interaction with antigen and with "B"-cells during the time of induction of IgG antibody formation.
D000276:Adjuvants, Immunologic; D000595:Amino Acid Sequence; D000596:Amino Acids; D000818:Animals; D000831:Animals, Newborn; D000888:Antibodies, Anti-Idiotypic; D000917:Antibody Formation; D016026:Bone Marrow Transplantation; D005260:Female; D005620:Freund's Adjuvant; D007114:Immunization; D007117:Immunization, Secondary; D007125:Immunogenetics; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins / Q000494:pharmacology; D007156:Immunologic Memory; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D011830:Radiation Effects; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*; D014184:Transplantation, Homologous
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D010455:Peptides; D005620:Freund's Adjuvant