A molecular model of action potentials.
A QUANTITATIVELY CONSISTENT MODEL OF NERVE ACTIVITY IS GIVEN IN TERMS OF TWO MAIN BIOCHEMICAL CYCLES NARROWLY INTERLOCKED: an acetylcholine cycle and a calcium cycle. The activity of both cycles is controlled among other things by the electric field and various allosteric effectors. As shown by digital simulations our model accounts for the basic properties of an action potential as described by the electrophysiologists. Thus the shape, time course, and behavior under voltage clamping conditions of both sodium and potassium permeability variations are adequately reproduced.
D000109:Acetylcholine / Q000378:metabolism; D000200:Action Potentials; D002118:Calcium / Q000378:metabolism; D003201:Computers; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials; D008959:Models, Neurological; D009420:Nervous System / Q000378:metabolism; D009424:Nervous System Physiological Phenomena; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium