Microtubule function in immune and nonimmune lymphocyte-mediated cytotoxicity.
Disaggregation of microtubular subunits in effector lymphocytes inhibits their ability to injure target cells. The inhibition is not reversed by denterium oxide, an agent known to stablize microtubular subunits.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002859:Chromium Isotopes; D003078:Colchicine / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D003903:Deuterium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008870:Microtubules / Q000187:drug effects / Q000502:physiology*; D010087:Oxides / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014747:Vinblastine / Q000494:pharmacology
D002859:Chromium Isotopes; D010087:Oxides; D014747:Vinblastine; D003903:Deuterium; D003078:Colchicine