Radioresistance of carrier-specific helper thymus-derived lymphocytes in mice.
The effect of x-irradiation on the capacity of carrier-specific mouse T (thymus-derived) lymphocytes to exert a helper function for hapten-specific B (bone marrow-derived) lymphocytes in vivo has been investigated again. Helper function is abolished by exposure of such cells to x-irradiation before, or immediately after, transfer to adoptive hosts. On the other hand, when exposure to x-irradiation occurs under circumstances in which the carrier-primed cells are well-localized in the appropriate lymphoid organs, i.e., either in the carrier-primed animal or 24 hr after adoptive transfer to syngeneic recipients, the capacity of T lymphocytes to serve as specific helper cells is clearly radioresistant. Evidence indicates that x-irradiation results in undefined, and subtle, changes in the migratory capacity of mouse T lymphocytes, but not in abrogation of T-cell helper function.
D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects*; D001402:B-Lymphocytes / Q000276:immunology; D001500:BCG Vaccine; D004140:Dinitrophenols; D007114:Immunization; D007116:Immunization, Passive; D007117:Immunization, Secondary; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D011830:Radiation Effects; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000528:radiation effects*
D001500:BCG Vaccine; D004140:Dinitrophenols