Cyclization of three N- -haloalkyl-N-methylaminoaceto-2,6-xylidide derivatives in relation to their local anesthetic effect in vitro and in vivo.
D000083:Acetanilides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000779:Anesthetics, Local / Q000494:pharmacology*; D000813:Anilides / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D003500:Cyclization; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007700:Kinetics; D008012:Lidocaine / Q000032:analysis; D009474:Neurons / Q000032:analysis; D011894:Rana pipiens; D012584:Sciatic Nerve / Q000378:metabolism; D013997:Time Factors; D014992:Xylenes / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
D000083:Acetanilides; D000779:Anesthetics, Local; D000813:Anilides; D002247:Carbon Isotopes; D014992:Xylenes; D008012:Lidocaine