Factor VIII coagulant activity and factor VIII-like antigen: independent molecular entities.
Factor VIII coagulant activity (VIII(C)) and the von Willebrand's disease antigen (Factor VIII-like antigen, vW-Ag) are biologically linked, and it has been suggested that they reside on the same molecule. However, insolubilized human isoantibody to VIII(C) and rabbit antiserum containing antibodies to VIII(C) and vW-Ag differentially bind and remove these entities from plasma, thus physically segregating one from the other. These findings indicate that Factor VIII coagulant activity resides on a molecule distinct from that expressing the von Willebrand's antigen.
D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis*; D001777:Blood Coagulation; D005169:Factor VIII / Q000032:analysis; D006801:Humans; D014842:von Willebrand Diseases / Q000097:blood / Q000276:immunology*
D000941:Antigens; D005169:Factor VIII