A factor that can be used to regulate an in vitro primary immune response.
A factor has been isolated that supports the stimulation of an immune response against heterologous erythrocyte antigens in mouse spleen cells cultured in a medium that contains deficient serum. The factor is secreted by certain spleen cells that are obtained in permanent culture after leukemia virus infection. The factor permits antigen-sensitive cells derived from bone marrow to mature to antibody-forming cells. This factor can be used in controlling the initiation of a primary immune response in vitro.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D000941:Antigens; D002460:Cell Line; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007106:Immune Sera; D007111:Immunity, Cellular; D007114:Immunization; D007942:Leukemia, Experimental / Q000209:etiology / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D009374:Neoplasms, Experimental / Q000276:immunology; D010954:Plasmacytoma / Q000276:immunology; D011925:Rauscher Virus; D013154:Spleen / Q000166:cytology / Q000276:immunology* / Q000382:microbiology
D000941:Antigens; D007106:Immune Sera