title: Therapeutic field trial of a macro- and microfilaricidal agent in canine filariasis.
abstract: The discovery in 1973 of a synergistic effect of the arsenical compound F 151, a macrofilaricide, and the benzimidazole compound HOE 33258, a microfilaricide, led to the preparation of the reaction product of F 151 and HOE 33258 (in the proportion 1 mol to 2 mol, respectively), which was designated by the letter E. This compound E proved to be an effective macro- and microfilaricidal agent when administered subcutaneously in a single well-tolerated dose to dogs that were naturally infected with Dirofilaria immitis.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D001152:Arsenicals / Q000008:administration & dosage; D001562:Benzimidazoles / Q000008:administration & dosage; D001769:Blood / Q000469:parasitology; D055598:Chemical Phenomena; D002621:Chemistry; D004183:Dirofilaria immitis; D004184:Dirofilariasis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005369:Filaricides / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D010879:Piperazines / Q000008:administration & dosage
chemical_list: D000871:Anthelmintics; D001152:Arsenicals; D001562:Benzimidazoles; D004338:Drug Combinations; D005369:Filaricides; D010879:Piperazines