Growth of Newcastle disease virus and rubella virus in rheumatoid and nonrehumatoid synovial cell cultures.
Rheumatoid and nonrheumatoid synovial cell cultures were challenged with Newcastle disease virus and rubella virus in an attempt to confirm reports that rheumatoid synovial cells are relatively resistant to infection with these viruses. Newcastle disease virus caused complete cell destruction by day 7 in both rheumatoid and nonrheumatoid cultures, and peak virus titers were similar. Rubella virus replicated in both rheumatoid and nonrheumatoid synovial cell cultures, and no consistent differences in virus titers were detected. Rubella-infected cell lines were observed for up to 28 days and no virus-specific cytopathic effect was seen.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D006821:Hyaluronoglucosaminidase / Q000032:analysis; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009522:Newcastle disease virus / Q000254:growth & development*; D012216:Rheumatic Diseases / Q000382:microbiology*; D012412:Rubella virus / Q000254:growth & development*; D013582:Synovial Fluid / Q000032:analysis / Q000201:enzymology / Q000382:microbiology*; D013997:Time Factors; D014776:Virus Cultivation; D014779:Virus Replication
D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase