title: Stimulation of unbalanced ribonucleic acid synthesis in Escherichia coli by methanol.
abstract: Addition of methanol to a stringent strain of Escherichia coli, starving of methionine, stimulates unbalanced ribonucleic acid (RNA) synthesis. The newly formed RNA and ribonucleoprotein species sediment between 4S and 30S. As a result of methanol treatment, cells become permeable to actinomycin D. Damage to cellular membrane appears to influence the control for RNA synthesis.
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival; D002499:Centrifugation, Density Gradient; D003124:Colorimetry; D003470:Culture Media; D003609:Dactinomycin / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism; D005827:Genetics, Microbial; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D000432:Methanol / Q000494:pharmacology*; D008715:Methionine; D009154:Mutation; D009698:Nucleoproteins / Q000096:biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis*; D014498:Uracil / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003470:Culture Media; D009698:Nucleoproteins; D012329:RNA, Bacterial; D003609:Dactinomycin; D014498:Uracil; D008715:Methionine; D007930:Leucine; D000432:Methanol