title: Proton nuclear magnetic resonance relaxation measurements in frog muscle.
abstract: Proton nuclear magnetic resonance (NMR) relaxation measurements are reported for frog muscle as a function of temperature and Larmor frequency. Each T(1rho), T(2), and T(1) measurement covered a time domain sufficient to identify the average relaxation time for most intracellular water. Using regression analysis the data were fit with a model where intracellular water molecules are exchanging between a large compartment in which mobility is similar to ordinary water and a small compartment in which motion is restricted. The regression results suggest that: the restricted compartment exhibits a distribution of motions skewed toward that of free water; the residence time of water molecules in the restricted compartment is approximately 1 ms; and, the activation entropy for some water molecules in the restricted compartment is negative.
mesh_terms: D000818:Animals; D001834:Body Water / Q000032:analysis; D006614:Hindlimb; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D008968:Molecular Conformation; D009132:Muscles / Q000032:analysis / Q000648:ultrastructure*; D011894:Rana pipiens; D012044:Regression Analysis; D013696:Temperature; D013997:Time Factors