title: Physiological factors in the regulation of alkaline phosphatase synthesis in Escherichia coli.
abstract: Alkaline phosphatase is induced in excess phosphate media by starvation either for pyrimidines or for guanine. Induction is observed both during starvation, after a lag period, and following a period of starvation. Induction is not caused by a lowering of the internal orthophosphate pool, but is linked to alterations in the levels of the nucleotide pools. Experiments with purine-requiring mutants suggest that phosphatase is induced in wild-type strains by an adenine nucleotide. Mutations in the phoR gene can produce differential responses to the different starvation regimes.
mesh_terms: D000225:Adenine / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D003470:Culture Media; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D005827:Genetics, Microbial; D006147:Guanine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D009154:Mutation; D009711:Nucleotides / Q000096:biosynthesis; D010710:Phosphates / Q000378:metabolism; D010759:Phosphorus Isotopes; D013941:Thymine / Q000378:metabolism; D014498:Uracil / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003470:Culture Media; D009711:Nucleotides; D010710:Phosphates; D010759:Phosphorus Isotopes; D014498:Uracil; D006147:Guanine; D000469:Alkaline Phosphatase; D007930:Leucine; D000225:Adenine; D013941:Thymine