Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.
Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incubation with subnanogram concentrations of thymin. The induced cells expressed more TL and Thy-1 (theta) antigens than average normal thymocytes.
D000818:Animals; D000906:Antibodies; D000918:Antibody Specificity; D000941:Antigens; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D003601:Cytotoxicity Tests, Immunologic; D006728:Hormones / Q000494:pharmacology; D007106:Immune Sera; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000276:immunology*
D000906:Antibodies; D000941:Antigens; D006728:Hormones; D007106:Immune Sera; D010455:Peptides; D013949:Thymus Extracts