Tranexamic acid in control of haemorrhage after dental extraction in haemophilia and Christmas disease.
In a double-blind trial tranexamic acid (AMCA, Cyclokapron), 1 g three times a day for five days, significantly reduced blood loss and transfusion requirements after dental extraction in patients with haemophilia and Christmas disease. No side effects were seen in either group of patients. Screening tests showed no toxic action of tranexamic acid on the liver, kidney, or heart.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D001799:Blood Sedimentation; D002859:Chromium Isotopes; D002986:Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D005340:Fibrinogen / Q000032:analysis; D006334:Heart Function Tests; D006467:Hemophilia A; D002836:Hemophilia B; D006801:Humans; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000517:prevention & control*; D014081:Tooth Extraction / Q000009:adverse effects*; D014508:Urea / Q000097:blood
D000933:Antifibrinolytic Agents; D002859:Chromium Isotopes; D003509:Cyclohexanecarboxylic Acids; D014508:Urea; D005340:Fibrinogen