Prolongation of the life-span in mice adapted to large amounts of L-dopa.
Various concentrations of L-dopa (levodopa, L-3,4-dihydroxyphenylalanine) were incorporated in the diets of young male Swiss albino mice, and the highest concentrations to which these mice became adapted within 3 weeks were determined. One such concentration administered indefinitely eventually induced a youthful appearance, a significantly prolonged life-span, but also corneal opacities compatible with traumatic or chemical keratitis.
D000818:Animals; D003318:Corneal Opacity / Q000139:chemically induced; D004032:Diet; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice
D004295:Dihydroxyphenylalanine