The effect of age on the fibrinolytic enzyme system.
Components of the fibrinolytic enzyme system, FR-antigen and fibrinogen, were measured in 20 healthy volunteers aged 20-40 years and in 61 elderly subjects aged 66-96 years. Plasminogen activator levels did not significantly differ between the 20-40 and 66-75 age groups, but were higher in those over 75. Plasminogen showed no change with age except for a fall in those over 75. Fibrinogen, FR-antigen, alpha(1)-antitrypsin, and alpha(2)-macroglobulin all rose with age, but the mean fibrinogen concentration fell in the very elderly.
D000328:Adult; D000368:Aged; D000375:Aging; D000941:Antigens / Q000032:analysis*; D004789:Enzyme Activation; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis; D006400:Hematocrit; D006801:Humans; D008259:Macroglobulins / Q000032:analysis; D008297:Male; D009765:Obesity / Q000201:enzymology; D010958:Plasminogen / Q000097:blood; D012885:Skinfold Thickness; D000515:alpha 1-Antitrypsin / Q000097:blood
D000941:Antigens; D008259:Macroglobulins; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D010958:Plasminogen