The enzymatic hydrolysis of a series of aminoacylanilides in relation to their nerve blocking effect and toxicity.
D000200:Action Potentials / Q000187:drug effects; D000581:Amidohydrolases; D000779:Anesthetics, Local; D000813:Anilides / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001001:Anura; D002417:Cattle; D005260:Female; D006868:Hydrolysis; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008706:Methemoglobin / Q000096:biosynthesis*; D051379:Mice; D009431:Neural Conduction / Q000187:drug effects*; D011817:Rabbits; D011893:Rana esculenta; D012584:Sciatic Nerve / Q000502:physiology; D014316:Tritium
D000779:Anesthetics, Local; D000813:Anilides; D014316:Tritium; D008706:Methemoglobin; D000581:Amidohydrolases