Field trial with human and equine influenza vaccines in children: protection and antibody titres.
A placebo-controlled influenza vaccination trial was carried out on 374 children in the winter of 1967-68. The children were randomly vaccinated with 300 CCA of A2/England/1/1966, 300 CCA of A/equine 2/Miami/1963, or with a placebo. During this winter an influenza outbreak occurred, caused by A2/Nederland/1968. The A2 vaccine yielded a protection rate of 58% (P = 0.02) and the A/equine 2 vaccine a rate of 19% (P = 0.33). Serological data revealed that all influenza infections occurred in subjects who had a pre-epidemic haemagglutination inhibition titre below 150. The antibody response against various human influenza A2 viruses and against the horse strain (A/equine 2) is discussed.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003168:Complement Fixation Tests; D006385:Hemagglutination Inhibition Tests; D006736:Horses; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control; D009426:Netherlands; D014611:Vaccination
D000906:Antibodies; D007252:Influenza Vaccines