title: Studies of combined quadruple vaccines against diphtheria, pertussis, tetanus, and typhoid fever: reactogenicity and antigenicity.
abstract: Different DPT + typhoid vaccines were produced by two laboratories and tested in the field for untoward local or systemic reactions and in the laboratory for immunogenic properties. The combined DPT and acetone-inactivated and dried typhoid antigen was found to cause more numerous and more severe local and systemic reactions than the DPT and DPT + typhoid (heat-thiomersal) vaccines. The antibody responses to all four antigens in both of the combined DPT + typhoid vaccines were very satisfactory.From the results of these studies it is concluded that quadruple DPT + typhoid vaccine is suitable for use in areas where typhoid fever is a problem and where logistic and other considerations require the use of combined vaccines.
mesh_terms: D000917:Antibody Formation; D001428:Bacterial Vaccines; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology*; D004338:Drug Combinations; D006801:Humans; D007223:Infant; D010567:Pertussis Vaccine; D013742:Tetanus / Q000276:immunology*; D014435:Typhoid Fever / Q000276:immunology; D014436:Typhoid-Paratyphoid Vaccines; D014917:Whooping Cough / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D004338:Drug Combinations; D010567:Pertussis Vaccine; D014436:Typhoid-Paratyphoid Vaccines