Schistosoma mansoni infection in mice depleted of thymus-dependent lymphocytes. I. Eosinophilia and immunologic responses to a schistosomal egg preparation.
Chronic murine schistosomiasis is characterized by a host cell-mediated immune response to schistosomal egg antigens. This response is manifested in vitro by lymphocyte blastogenic reactivity to a soluble schistosomal egg antigen preparation (SEA) and in vivo by delayed dermal hypersensitivity to SEA. In addition, mice develop reaginic, agglutinating, and early dermal reactive antibodies to SEA and a characteristic pattern of peripheral blood eosinophilia. In this study, depletion of thymus-dependent lymphocytes abolished the anti-SEA lymphocyte blastogenic response and delayed dermal reactivity, reaginic antibody response and the major peak of peripheral blood eosinophilia, which in normal mice occurs at the same time as SEA-induced blastogenesis. Antibodies mediating the early dermal reaction to SEA and agglutinins for SEA-coated particles were not inhibited by T-lymphocyte depletion. The experimental group did not develop the normally observed granulomatous response, but rather suffered focal hepatic and mucosal liquefactive necrosis, bacteremia and accelerated mortality.
D000371:Agglutination; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D004804:Eosinophils / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007106:Immune Sera; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008297:Male; D008722:Methods; D051379:Mice; D008808:Mice, Inbred CBA; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology* / Q000401:mortality; D012867:Skin / Q000276:immunology; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D007106:Immune Sera