A possible mechanism for the antischizophrenic action of chlorpromazine: inhibition of the formation of dimethyltryptamine by chlorpromazine metabolites.
D000818:Animals; D002250:Carbon Radioisotopes; D002746:Chlorpromazine / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003891:Desipramine / Q000378:metabolism; D006213:Hallucinogens / Q000037:antagonists & inhibitors*; D006801:Humans; D007099:Imipramine / Q000378:metabolism; D066298:In Vitro Techniques; D007211:Indoles; D008168:Lung / Q000201:enzymology; D013058:Mass Spectrometry; D008745:Methylation; D008780:Methyltransferases / Q000302:isolation & purification; D004130:N,N-Dimethyltryptamine / Q000037:antagonists & inhibitors / Q000378:metabolism; D011817:Rabbits; D012436:S-Adenosylmethionine / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy*; D012701:Serotonin / Q000378:metabolism; D012997:Solvents; D013763:Tetrahydrofolates / Q000378:metabolism; D013997:Time Factors; D014363:Tryptamines / Q000037:antagonists & inhibitors*
D002250:Carbon Radioisotopes; D006213:Hallucinogens; D007211:Indoles; D012997:Solvents; D013763:Tetrahydrofolates; D014363:Tryptamines; D012701:Serotonin; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D007099:Imipramine; D003891:Desipramine; D002746:Chlorpromazine; D004130:N,N-Dimethyltryptamine