Effect of development and aging on the response of canine lymphocytes to phytohemagglutinin.
The stage of development and age were found to effect the responsiveness of dog T-lymphocytes to phytohemagglutinin. T-lymphocytes from beagles 0 to 4 weeks of age showed significantly less response to phytohemagglutinin (P < 0.001) than T-lymphocytes from these same dogs at 6 to 12 weeks of age. Peak response to phytohemagglutinin occurred between 6 weeks to 6 months of age, after which there was a significant correlation (P < 0.02) between increase in age and decrease in phytohemagglutinin responsiveness.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004285:Dogs; D037102:Lectins; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D037102:Lectins; D014316:Tritium; D013936:Thymidine