Treatment of acute massive pulmonary embolism by streptokinase during labour and delivery.
A 29-year-old woman sustained an acute massive pulmonary embolism in the 32nd week of pregnancy. Rapid clinical improvement followed the use of streptokinase. Treatment was continued for 41 hours, including labour and the first three hours after delivery. There was slow but severe postpartum haemorrhage. Partial uterine atony occurred, and may have been due, at least in part, to fibrin degradation products arising from thrombolysis. No adverse effects were noted in the baby.Our experience suggests that streptokinase may be given during labour but that an oxytocic agent may be needed; and that reversal of fibrinolysis before delivery is best achieved by the use of aprotinin (Trasylol) rather than aminocaproic acid.
D000208:Acute Disease; D000328:Adult; D000614:Aminocaproates / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007744:Obstetric Labor Complications; D006473:Postpartum Hemorrhage / Q000150:complications; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy*; D013300:Streptokinase / Q000627:therapeutic use*; D014593:Uterine Inertia / Q000150:complications
D000614:Aminocaproates; D007611:Aprotinin; D013300:Streptokinase