title: Clinical trials and pharmacokinetics of intermittent high-dose methotrexate-"leucovorin rescue" for children with malignant tumors.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008080:Liposarcoma / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D012516:Osteosarcoma / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D012512:Sarcoma, Ewing / Q000188:drug therapy; D013724:Teratoma / Q000188:drug therapy
chemical_list: D001219:Aspartate Aminotransferases; D002955:Leucovorin; D008727:Methotrexate