Cytochemical profile of B and T leukaemic lymphocytes with special reference to acute lymphoblastic leukaemia.
The PAS and acid phosphatase reactions showed a different pattern of positivity in the cells of lymphoproliferative disorders according to their B or T cell nature. In B-cell leukaemias (chronic lymphocytic and prolymphocytic) a low proportion of lymphocytes gave a positive result with the acid phosphatase reaction, while the majority were PAS positive in granular form. In contrast, in the T-prolymphocytic and T-lymphoblastic leukaemias the acid phosphatase reaction was positive in the majority of cells, while the PAS reaction was only positive in a minority. The significance of these findings, particularly for the recognition of a distinct T-cell variant of acute lymphoblastic leukaemia, is discussed.
D000135:Acid Phosphatase / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000145:classification* / Q000378:metabolism; D002452:Cell Count; D002462:Cell Membrane / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes / Q000145:classification* / Q000378:metabolism
D000135:Acid Phosphatase