Thymineless death in polA+ and polA- strains of Escherichia coli.
The extreme sensitivity of polA(-) cells to thymineless death is due, primarily, to the absence of an extended lag prior to the commencement of death. Once thymineless death has commenced, the rate in polA(-) cells is only slightly faster than in polA(+) cells.
D003470:Culture Media; D004254:DNA Nucleotidyltransferases / Q000096:biosynthesis*; D004260:DNA Repair; D004269:DNA, Bacterial / Q000096:biosynthesis; D004926:Escherichia coli / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism; D009154:Mutation; D013831:Thiamine / Q000378:metabolism; D013941:Thymine / Q000378:metabolism*
D003470:Culture Media; D004269:DNA, Bacterial; D008715:Methionine; D004254:DNA Nucleotidyltransferases; D013941:Thymine; D013831:Thiamine