Cell-mediated immune reactivity in liver disease.
Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodies.Cell-mediated immunity to parotid extract was shown in 10 cases (28%). This is in accord with the occurrence of the sicca syndrome in liver disease, which has been confirmed in this study.
D000941:Antigens; D001327:Autoimmune Diseases; D002464:Cell Migration Inhibition; D005455:Fluorescent Antibody Technique; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes; D008099:Liver; D008105:Liver Cirrhosis, Biliary / Q000276:immunology*; D008213:Lymphocyte Activation; D010306:Parotid Gland; D012859:Sjogren's Syndrome / Q000209:etiology; D014020:Tissue Extracts
D000941:Antigens; D014020:Tissue Extracts