Influence of gonadectomy on Candida albicans urinary tract infection in CFW mice.
Candida albicans appeared in the urine of approximately 80% of CFW mice of both sexes within 2 weeks after intraperitoneal inoculation. During a follow-up period of 10 weeks, candiduria tended to clear, but persisted in 37% of males as compared to only 16% in females. Autopsy kidney cultures yielded candida in 53% of males as compared to 25% of females. Urine cultures in both sexes when positive contained 10(3.5) to 10(4.5) candida/ml regardless of the outcome of the infection. Preinoculation gonadectomy in both sexes increased resistance to the infection but did not alter the quantitative aspects of candiduria.
D000818:Animals; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000382:microbiology / Q000652:urine*; D002369:Castration; D005260:Female; D006066:Gonads / Q000502:physiology; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors; D014552:Urinary Tract Infections / Q000382:microbiology*