Luteinizing hormone and follicle stimulating hormone-releasing hormone test in patients with hypothalamic-pituitary-gonadal dysfunction.
A standard intravenous 100 mug luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH) test was used to assess the pituitary gonadotrophin responses in 155 patients with a variety of diseases of the hypothalamic-pituitary-gonadal axis. In all but nine patients there was an increase in circulating levels of either LH or FSH in response to the releasing hormone though 137 (88%) were clinically hypogonadal. It was not possible with this test to distinguish between hypothalamic and pituitary causes of hypogonadotrophic hypogonadism, since a variety of LH and FSH responses emerged within the disease groups. However, primary gonadal failure characteristically resulted in exaggerated gonadotrophin response. The potential therapeutic use of the gonadotrophin releasing decapeptide is suggested in certain patients with hypogonadotrophic hypogonadism.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000150:complications / Q000175:diagnosis; D002648:Child; D004700:Endocrine System Diseases / Q000175:diagnosis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis* / Q000188:drug therapy; D007030:Hypothalamo-Hypophyseal System; D007986:Luteinizing Hormone / Q000627:therapeutic use; D008297:Male; D010455:Peptides / Q000627:therapeutic use; D010900:Pituitary Diseases / Q000175:diagnosis*; D010906:Pituitary Hormone-Releasing Hormones / Q000627:therapeutic use
D006062:Gonadotropins; D010455:Peptides; D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone