title: Treatment of renal failure from diabetic nephropathy with cadaveric homograft.
abstract: We report two patients with terminal renal failure secondary to diabetic nephropathy treated with cadaveric kidney transplantation. Neither of these patients had peripheral vascular disease or peripheral neuropathy. There was a proliferative diabetic retinopathy with hemorrhages and exudates in one patient and only background diabetic changes in the ocular fundi of the other; there have been no significant changes in visual acuity or retinopathy in either patient following the transplantation. Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency.
mesh_terms: D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003930:Diabetic Retinopathy / Q000150:complications; D006084:Graft Rejection; D006801:Humans; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008722:Methods; D008750:Methyldopa / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D014184:Transplantation, Homologous; D014792:Visual Acuity
chemical_list: D000961:Antilymphocyte Serum; D049528:Insulin, Long-Acting; D008750:Methyldopa; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone