Peroxidase mediated antimicrobial activities of alveolar macrophage granules.
The 20,000g pellet obtained by centrifugation of a homogenate of rabbit alveolar macrophages has antibacterial activity in the presence of a hydrogen peroxide-generating system and iodide. Peroxidase activity has been demonstrated in this fraction. Addition of 3-amino-1,2,4-triazole diminished the antibacterial activity of the pellet-hydrogen peroxide-iodide system.
D000409:Alanine; D000818:Animals; D002247:Carbon Isotopes; D003653:Decarboxylation; D004926:Escherichia coli / Q000187:drug effects; D008264:Macrophages / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D010544:Peroxidases / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010587:Phagocytosis; D011650:Pulmonary Alveoli / Q000166:cytology*; D011817:Rabbits; D014230:Triazoles / Q000494:pharmacology
D002247:Carbon Isotopes; D014230:Triazoles; D010544:Peroxidases; D000409:Alanine