Selective autocytotoxicity in a model system of Escherichia coli K-12 recombinants.
Autocytotoxicity was shown by Lac(+) recombinant strains of Escherichia coli K-12 when their growth was inhibited in media containing o-nitrophenyl-beta-d-galactopyranoside. Lac(-) strains without lactose permease or beta-galactosidase activity grew well. Selective autocytotoxicity was shown by simultaneous inhibition of Lac(+) cells and multiplication of Lac(-) cells grown together in this medium.
D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D005690:Galactose; D005696:Galactosidases / Q000096:biosynthesis / Q000378:metabolism*; D006027:Glycosides / Q000378:metabolism; D007785:Lactose; D026901:Membrane Transport Proteins / Q000096:biosynthesis / Q000378:metabolism*; D009578:Nitrobenzenes; D009596:Nitrophenols / Q000096:biosynthesis / Q000494:pharmacology; D011995:Recombination, Genetic
D003470:Culture Media; D006027:Glycosides; D026901:Membrane Transport Proteins; D009578:Nitrobenzenes; D009596:Nitrophenols; D005696:Galactosidases; D007785:Lactose; D005690:Galactose