Alteration in antibody response induced by carbon inhalation: a model system.
The immune response in mice to antigens given by intraperitoneal, intravenous, and inhalation routes was compared in control and carbon-dust exposed mice. The most pronounced effect, a decrease in antibody-forming cells and serum agglutinin titers, was observed when the carbon-treated animals were immunized with antigens in the form of aerosol. Similar results were obtained when the antigens were administered by intravenous or intraperitoneal route. In contrast 4-days of pre-exposure to carbon dust increased the number of antibody-forming cells in the mediastinal lymph nodes. However, this effect was transient and was not significant when the carbon pre-exposure was continued for 15 days.
D000336:Aerosols; D000704:Analysis of Variance; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000942:Antigens, Bacterial / Q000008:administration & dosage; D002244:Carbon / Q000008:administration & dosage / Q000494:pharmacology*; D004391:Dust; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008954:Models, Biological; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000336:Aerosols; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D004391:Dust; D002244:Carbon