title: Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis.
abstract: The effects of phenformin and ethyloestrenol and phenformin and stanozolol on the clinical state, plasma fibrinolytic activity, and fibrinogen-fibrin-related antigen (F.R.-antigen) were compared with placebo in 13 patients with cutaneous vasculitis. Eight patients showed considerable clinical improvement when taking phenformin and an anabolic steroid; an impaired fibrinolytic activity before treatment favoured clinical improvement.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens; D001780:Blood Coagulation Tests; D002986:Clinical Trials as Topic; D005032:Ethylestrenol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005337:Fibrin; D005340:Fibrinogen; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010629:Phenformin / Q000494:pharmacology / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy*; D013197:Stanozolol / Q000494:pharmacology / Q000627:therapeutic use*; D014652:Vascular Diseases / Q000188:drug therapy*
chemical_list: D000941:Antigens; D013197:Stanozolol; D005337:Fibrin; D005340:Fibrinogen; D005032:Ethylestrenol; D010629:Phenformin