Induction of labour by simultaneous intravenous administration of prostaglandin E 2  and oxytocin.
In a group of 20 matched primigravid patients labour was induced by forewater amniotomy followed by intravenous oxytocin (Syntocinon) administered in escalating doses. Ten of these patients, in a double-blind trial, also received prostaglandin E(2) infused simultaneously with the oxytocin. In the combined prostaglandin-oxytocin group there was a noticeable reduction in the dosage of oxytocin required to produce effective uterine action, and the duration of labour was also reduced. No side effects were observed.
D000650:Amnion / Q000601:surgery; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D010121:Oxytocin / Q000008:administration & dosage*; D010919:Placebos; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage*; D013997:Time Factors
D004338:Drug Combinations; D010919:Placebos; D011453:Prostaglandins; D010121:Oxytocin