Effect of human adenoviruses on the response of chickens to sheep erythrocytes.
Human adenovirus types 6, 8, and 12 were immunosuppressive in chickens. A single intravenous injection of adenoviruses markedly depressed the 19S hemolytic plaque-forming cell response in the spleen to the immunization with sheep red blood cells. Hemagglutinin production was also decreased in adenovirus type 6-infected chickens. Adenoviruses caused a transient immunosuppression in chickens which could be detected 2 to 3 days after the virus infection, and no depressive effect was found 16 to 20 days after virus injection. The possible mechanism of immunosuppression observed is discussed.
D000256:Adenoviridae / Q000276:immunology* / Q000472:pathogenicity; D000818:Animals; D000917:Antibody Formation; D002645:Chickens; D003165:Complement System Proteins; D004912:Erythrocytes / Q000276:immunology*; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007165:Immunosuppression Therapy; D009500:Neutralization Tests; D009929:Organ Size; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014357:Trypsin; D014361:Trypsin Inhibitors
D014361:Trypsin Inhibitors; D003165:Complement System Proteins; D014357:Trypsin