Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans.
D000818:Animals; D001120:Arginine / Q000378:metabolism; D002268:Carboxypeptidases / Q000378:metabolism; D002499:Centrifugation, Density Gradient; D002850:Chromatography, Gel; D003594:Cytoplasmic Granules / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004952:Esters / Q000378:metabolism; D005260:Female; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism; D011384:Proinsulin / Q000378:metabolism*; D011480:Protease Inhibitors; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014105:Tosyl Compounds / Q000378:metabolism; D014316:Tritium; D014357:Trypsin / Q000378:metabolism
D004952:Esters; D007328:Insulin; D010455:Peptides; D011480:Protease Inhibitors; D014105:Tosyl Compounds; D014316:Tritium; D011384:Proinsulin; D001120:Arginine; D002268:Carboxypeptidases; D014357:Trypsin; D007930:Leucine