Sotalol for the protection of turkeys from the development of  -aminopropionitrile-induced aortic ruptures.
1. The influence of feeding 2 levels of sotalol on the incidence of beta-aminopropionitrile (BAPN)-induced aortic ruptures of immature turkeys was determined.2. Four of 22 turkeys fed 0.12% sotalol and 0.07% BAPN died of aortic ruptures, but 6 of 21 turkeys fed only BAPN died of the syndrome.3. Blood pressure, heart rate, aortic tensile strength, and aortic structure as seen by light- and electron-microscope were similar in turkeys fed BAPN alone or both BAPN and 0.12% sotalol concurrently.4. In a second experiment, 13 of 24 turkeys fed 0.7% BAPN alone died of aortic ruptures, but only 2 of 24 turkeys fed BAPN and 0.2% sotalol concurrently died of the disease.5. Aortic tensile strength was lower, heart rate was faster, alterations of aortic elastic fibres as seen by light- and electron-microscope were more severe, and aortic salt soluble collagen with a higher amino acid content was increased in turkeys fed only BAPN, as compared to turkeys fed both BAPN and 0.2% sotalol.
D000629:Aminopropionitrile; D000818:Animals; D001011:Aorta / Q000473:pathology; D001019:Aortic Rupture / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D006339:Heart Rate / Q000187:drug effects; D006652:Histological Techniques; D008854:Microscopy, Electron; D013015:Sotalol / Q000627:therapeutic use*; D013577:Syndrome; D014422:Turkeys
D000629:Aminopropionitrile; D013015:Sotalol