title: Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: a demonstration of a switch of cell types in clonal cell culture.
abstract: Clonal cell lines isolated from the pigmented retina of 8.5-day chick embryos initially retained the capacity to form pigment. After several passages, however, many cells lost pigment granules and differentiated into lens-like structures. The lens-specific nature of the structures formed in cultures originally derived from retinal pigment cells was established by both ultrastructural and immunological studies.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002469:Cell Separation; D002642:Chick Embryo; D002999:Clone Cells; D003470:Culture Media; D003594:Cytoplasmic Granules; D005455:Fluorescent Antibody Technique; D007908:Lens, Crystalline / Q000166:cytology* / Q000276:immunology; D008854:Microscopy, Electron; D011817:Rabbits / Q000276:immunology; D012160:Retina / Q000166:cytology*; D012168:Retinal Pigments
chemical_list: D003470:Culture Media; D012168:Retinal Pigments