Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial.
The bone mineral mass was estimated by photon absorptiometry in 23 epileptic patients on long-term treatment with phenytoin and in 20 normal subjects before and during treatment with vitamin D or placebo.Initially, subnormal values of bone mineral mass were found in the epileptic patients. The group of epileptic patients treated with vitamin D showed a significant increase in bone mineral mass. The group of epileptic patients treated with placebo and the normal subjects treated with vitamin D or placebo showed no change in bone mineral mass.
D000042:Absorption; D000328:Adult; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D010672:Phenytoin / Q000627:therapeutic use*; D010919:Placebos; D013997:Time Factors; D014807:Vitamin D / Q000494:pharmacology / Q000627:therapeutic use*
D008903:Minerals; D010919:Placebos; D014807:Vitamin D; D010672:Phenytoin; D002118:Calcium