Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol).
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001921:Brain / Q000201:enzymology*; D004285:Dogs; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008025:Ligases / Q000037:antagonists & inhibitors*; D011453:Prostaglandins; D011817:Rabbits; D013154:Spleen / Q000201:enzymology
D011453:Prostaglandins; D000082:Acetaminophen; D008025:Ligases; D001241:Aspirin; D007213:Indomethacin