Antiglobulins in endocarditis.
Twenty-five patients with endocarditis and serum antiglobulin activity were studied. The antiglobulins were detected by use of the latex agglutination reaction; only eight sera reacted with sensitized sheep cells and one with human O CD erythrocytes coated with anti-CD (Ripley) antibody. Absorption of the sera with the infecting organisms produced a decrease in antiglobulin activity in 10 of these sera. Absorption with other reference bacteria did not lower the titer of latex agglutination in 9 of 10 of these sera. No inhibition of antiglobulin activity by autologous immunoglobulin G was demonstrable. These findings suggest that some antiglobulins interact with the immunoglobulin G-bacterial complex and are analogous to anti-antibodies.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D004696:Endocarditis / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007841:Latex Fixation Tests; D012756:Sheep / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology; D013290:Streptococcal Infections / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007075:Immunoglobulin M