Inhibition of thiamine transport by chloroethylthiamine in Escherichia coli.
Chloroethylthiamine was found to inhibit an entrapment of thiamine as thiamine monophosphate by blocking thiamine monophosphokinase in the cytoplasm after thiamine was taken up by the cells of Escherichia coli.
D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001693:Biological Transport, Active; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D003593:Cytoplasm; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D009154:Mutation; D010710:Phosphates / Q000096:biosynthesis; D010770:Phosphotransferases / Q000037:antagonists & inhibitors; D013831:Thiamine / Q000096:biosynthesis / Q000378:metabolism*; D013997:Time Factors
D000981:Antiprotozoal Agents; D002247:Carbon Isotopes; D010710:Phosphates; D010770:Phosphotransferases; D013831:Thiamine