Inhibitory and stimulatory effects of secretin on gastric secretion in conscious rats.
1. The effect of pure secretin on gastrin-induced secretion has been studied in conscious rats with Pavlov or Heidenhain pouches.2. Rapid intravenous injection of secretin did not inhibit a plateau secretion of acid in the Heidenhain pouch, but infusion of the same amount of secretin over two hours inhibited secretion in both Heidenhain and Pavlov pouches.3. A rapid intravenous injection of secretin before the onset of gastrin infusion enhanced the acid secretory response to gastrin in both types of pouches.4. Secretin stimulated pepsin secretion.
D000818:Animals; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D005755:Gastrins / Q000494:pharmacology; D007275:Injections, Intravenous; D010434:Pepsin A / Q000378:metabolism; D051381:Rats; D012633:Secretin / Q000008:administration & dosage / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects
D005755:Gastrins; D012633:Secretin; D010434:Pepsin A