Analysis of nuclear disruption and binding of intermediates in host DNA breakdown to membranes after infection of Escherichia coli with bacteriophages T4 and T7.
Escherichia coli DNA polymerase I is implicated in the binding of intermediates in host DNA breakdown to membrane in T4-infected, but not T7-infected, cells. Nuclear disruption is observed in T4-infected polA1 mutant cells.
D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus; D003090:Coliphages / Q000201:enzymology / Q000254:growth & development*; D004254:DNA Nucleotidyltransferases / Q000096:biosynthesis; D004267:DNA Viruses / Q000201:enzymology / Q000254:growth & development*; D004269:DNA, Bacterial / Q000378:metabolism*; D004720:Endonucleases / Q000096:biosynthesis; D004926:Escherichia coli / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D005796:Genes; D008854:Microscopy, Electron; D009154:Mutation
D004269:DNA, Bacterial; D004254:DNA Nucleotidyltransferases; D004720:Endonucleases