Rapid microbiological assay for 5-fluorocytosine.
A microbiological assay was developed for 5-fluorocytosine based on inhibition by the drug of the fall in pH produced by Candida albicans in a synthetic liquid culture medium. Serum and urine levels of the drug could be measured reproducibly in four hours.
D000935:Antifungal Agents / Q000032:analysis*; D001681:Biological Assay; D002176:Candida albicans / Q000187:drug effects; D003470:Culture Media; D003596:Cytosine / Q000032:analysis*; D005437:Flucytosine / Q000032:analysis / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D013997:Time Factors
D000935:Antifungal Agents; D003470:Culture Media; D003596:Cytosine; D005437:Flucytosine