Effect in mice of injection of viable Candida albicans and a cell-free sonic extract on circulating platelets.
The ability of intravenously injected Candida albicans to cause thrombocytopenia and clotting disorders was tested. Mice injected in this manner showed a decrease in circulating platelets and a shortening of clotting time within hours after challenge. Treatment with heparin changed the death distribution pattern, but did not increase overall long-term survival. A cell-free sonic extract prepared from viable C. albicans cells was shown to cause aggregation of platelets in vitro, and injection of the cell-free extract into mice caused a decrease in circulating platelets similar to that observed when viable organisms were injected.
D000818:Animals; D001772:Blood Cell Count; D001778:Blood Coagulation Disorders / Q000209:etiology*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D002176:Candida albicans / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D002177:Candidiasis / Q000097:blood*; D002474:Cell-Free System; D004195:Disease Models, Animal; D006400:Hematocrit; D006493:Heparin / Q000494:pharmacology; D051379:Mice; D010973:Platelet Adhesiveness / Q000187:drug effects*; D018805:Sepsis / Q000382:microbiology; D013921:Thrombocytopenia / Q000209:etiology*; D014774:Virulence
D006493:Heparin