Behavioural studies of the actions of cocaine, monoamine oxidase inhibitors and iminodibenzyl compounds on central dopamine neurones.
1. Turning behaviour after unilateral lesions of the nigro-striatal dopamine pathway in rats has been used to compare the actions of cocaine and desipramine on central dopamine-containing neurones.2. Administration of cocaine alone (5-20 mg/kg) resulted in no turning or minimal turning towards the lesioned side; the monoamine oxidase inhibitors nialamide and pargyline administered alone were also ineffective.3. After pre-treatment with nialamide (100 mg/kg) or pargyline (25 mg/kg) cocaine evoked high rates of turning towards the lesioned side.4. Desipramine (1-100 mg/kg), either alone or in combination with nialamide did not evoke turning.5. Turning evoked by the cocaine-nialamide combination was abolished by pre-treatment with alpha-methyl-p-tyrosine (150 mg/kg).6. Pre-treatment with reserpine (5 mg/kg, 24 h previously) substantially diminished turning evoked by the cocaine-nialamide combination but potentiated turning resulting from administration of methylamphetamine (5 mg/kg).7. Cocaine (20 mg/kg) administered 15 min prior to (+)-methylamphetamine (5 mg/kg) reduced the turning behaviour in the first hour after administration of the latter drug but prolonged the total duration of the effect.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002395:Catecholamines / Q000037:antagonists & inhibitors; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000502:physiology; D003891:Desipramine; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009526:Nialamide / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000502:physiology; D013997:Time Factors
D002395:Catecholamines; D008781:Methyltyrosines; D008996:Monoamine Oxidase Inhibitors; D008694:Methamphetamine; D012110:Reserpine; D010293:Pargyline; D000661:Amphetamine; D003042:Cocaine; D009526:Nialamide; D003891:Desipramine; D004298:Dopamine