Immunodepression by Rowson-Parr virus in mice. I. Growth curves of Rowson-Parr virus and immunological relationships with Friend virus.
The growth curve of Rowson-Parr virus (RPV) was studied in the spleen of mice infected with RPV only and of mice infected with Friend virus (FV) preparations, which consist of a mixture of RPV and FV. In mice infected with FV preparations, RPV replicated to a higher titer than FV and attained higher levels than in singly infected mice. The chronic viremia of RPV-infected mice was found to coexist with circulating anti-RPV antibodies. These antibodies also neutralize FV and are probably responsible for the resistance against FV conferred to mice by prior infection with RPV.
D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral; D000961:Antilymphocyte Serum; D003429:Cross Reactions; D005622:Friend murine leukemia virus / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D009929:Organ Size; D011817:Rabbits / Q000276:immunology; D012526:Satellite Viruses / Q000276:immunology*; D013154:Spleen; D013950:Thymus Gland / Q000276:immunology; D014776:Virus Cultivation; D014779:Virus Replication
D000914:Antibodies, Viral; D000961:Antilymphocyte Serum