Tryptophol formation by Zygosaccharomyces priorianus.
Zygosaccharomyces priorianus converted L-tryptophan to tryptophol and to small quantities of indole-3-acetic acid. Neither tryptophol nor indole-3-acetic acid was metabolized when added separately to growing cultures. The possible intermediacy of indole-3-pyruvic acid, indole-3-acetaldehyde, and tryptamine in the degradation of L-tryptophan was tested by feeding these compounds to Z. priorianus and Saccharomyces cerevisiae. Indole-3-pyruvic acid and indole-3-acetaldehyde were converted to tryptophol and indole-3-acetic acid, with the latter accumulating only in small amounts. Tryptamine was converted to its N-acetyl derivative by these organisms. A qualitative study was made on the metabolism of L-phenylalanine, L-tyrosine, and L-5-hydroxytryptophan by these organisms. Like L-tryptophan, these amino acids were metabolized to their respective alcohol and acid derivatives. Of a large number of organisms tested, the yeasts possessed the highest capacity for degrading L-tryptophan to tryptophol.
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000079:Acetaldehyde / Q000378:metabolism; D000605:Amino Alcohols / Q000096:biosynthesis* / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005285:Fermentation; D005470:Fluorometry; D007210:Indoleacetic Acids / Q000096:biosynthesis / Q000378:metabolism; D007211:Indoles / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D010649:Phenylalanine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D012440:Saccharomyces / Q000254:growth & development / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000254:growth & development / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D014363:Tryptamines / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D000605:Amino Alcohols; D007210:Indoleacetic Acids; D007211:Indoles; D011773:Pyruvates; D014363:Tryptamines; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D000079:Acetaldehyde