Lysis of Escherichia coli by glycine is potentiated by pyridoxine starvation.
Pyridoxineless mutants of Escherichia coli are lysed in a few hours when starved for pyridoxine in a glucose minimal medium containing glycine at 10 mM. The lysis is prevented equally well by l-alanine and by d-alanine when either is present at 0.1 mM. The lysis is potentiated by 0.5 mM l-methionine. The peculiar susceptibility of E. coli B to glycine-mediated lysis during starvation for pyridoxine suggests that the starvation reduces the availability of some normal antagonist of glycine, presumably alanine.
D000409:Alanine / Q000494:pharmacology; D001433:Bacteriolysis / Q000187:drug effects; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000494:pharmacology*; D008715:Methionine / Q000494:pharmacology; D009154:Mutation; D011736:Pyridoxine / Q000096:biosynthesis / Q000378:metabolism*; D013237:Stereoisomerism
D003470:Culture Media; D008715:Methionine; D005947:Glucose; D011736:Pyridoxine; D000409:Alanine; D005998:Glycine