title: Mechanism of action of a rifamycin derivative (AF-013) which is active on the nucleic acid polymerases insensitive to rifampicin.
mesh_terms: D000410:Alanine Transaminase / Q000037:antagonists & inhibitors; D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors; D002417:Cattle; D002499:Centrifugation, Density Gradient; D055598:Chemical Phenomena; D002621:Chemistry; D004254:DNA Nucleotidyltransferases / Q000032:analysis; D012321:DNA-Directed RNA Polymerases / Q000032:analysis / Q000037:antagonists & inhibitors*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D009154:Mutation; D012293:Rifampin / Q000494:pharmacology; D012294:Rifamycins / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013395:Sucrose; D013698:Templates, Genetic
chemical_list: D012294:Rifamycins; D012710:Serum Albumin, Bovine; C006019:AF 013; D013395:Sucrose; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D004254:DNA Nucleotidyltransferases; D012321:DNA-Directed RNA Polymerases; D000469:Alkaline Phosphatase; D012293:Rifampin