title: Spontaneous tranformation of human brain cells grown in vitro and description of associated viurs particles.
abstract: A human brain cell culture grown in vitro has spontaneously transformed, as determined by morphology, growth characteristics, and karyotype analysis. Virus particles morphologically akin to oncogenic RNA viruses are present in the transformed cells, which are now in subculture 60.
mesh_terms: D001921:Brain / Q000166:cytology* / Q000382:microbiology; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D007562:Creutzfeldt-Jakob Syndrome; D006801:Humans; D007621:Karyotyping; D008854:Microscopy, Electron; D009858:Oncogenic Viruses / Q000302:isolation & purification*; D012328:RNA Viruses / Q000302:isolation & purification*