Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes.
Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D003168:Complement Fixation Tests; D005455:Fluorescent Antibody Technique; D005620:Freund's Adjuvant; D007114:Immunization; D008861:Microsomes / Q000276:immunology*; D011817:Rabbits; D013961:Thyroid Gland / Q000166:cytology / Q000276:immunology*; D013966:Thyroiditis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies; D005620:Freund's Adjuvant