Tropism of Mycoplasma gallisepticum for arterial walls.
The fatal encephalopathy associated with M. gallisepticum strain S6 in turkey poults was completely curable by treatment with tylosin or pleuromutilin. The lesions of cerebral polyarteritis disappeared after therapy. Polyarthritis developed in some birds after recovery from encephalitis. Immunofluorescent studies revealed that intravenously injected organisms became localized as microcolonies within the walls of cerebral and periarticular arteries, and in the glomeruli. Turkey IgG deposition was demonstrated on the glomerular basement membranes, but not in the arterial lesions. The results suggest that the pathologic changes caused by this microorganism are due to selective localization and growth in arteries.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000942:Antigens, Bacterial; D001158:Arteries / Q000276:immunology / Q000382:microbiology*; D001168:Arthritis / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D001921:Brain / Q000473:pathology; D002536:Cerebral Arteries / Q000276:immunology; D003516:Cycloparaffins / Q000627:therapeutic use; D004224:Diterpenes; D005455:Fluorescent Antibody Technique; D006016:Glycolates / Q000627:therapeutic use; D007668:Kidney / Q000276:immunology; D009174:Mycoplasma / Q000276:immunology / Q000302:isolation & purification*; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D011083:Polycyclic Compounds; D011201:Poultry Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D014422:Turkeys; D000097567:Pleuromutilins
D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D003516:Cycloparaffins; D004224:Diterpenes; D006016:Glycolates; D011083:Polycyclic Compounds; D000097567:Pleuromutilins