Treatment of renal failure from diabetic nephropathy with cadaveric homograft.
We report two patients with terminal renal failure secondary to diabetic nephropathy treated with cadaveric kidney transplantation. Neither of these patients had peripheral vascular disease or peripheral neuropathy. There was a proliferative diabetic retinopathy with hemorrhages and exudates in one patient and only background diabetic changes in the ocular fundi of the other; there have been no significant changes in visual acuity or retinopathy in either patient following the transplantation. Both have good kidney function after 8 and 15 months and are completely rehabilitated.The requirement for insulin decreased in both patients during the period of renal insufficiency and increased following transplantation; this seemed to be related to the large dose of steroids given because now that a maintenance level of steroids has been established, both patients require the same dosage of insulin as they did before the onset of renal insufficiency.
D000328:Adult; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D003930:Diabetic Retinopathy / Q000150:complications; D006084:Graft Rejection; D006801:Humans; D049528:Insulin, Long-Acting / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008722:Methods; D008750:Methyldopa / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D014184:Transplantation, Homologous; D014792:Visual Acuity
D000961:Antilymphocyte Serum; D049528:Insulin, Long-Acting; D008750:Methyldopa; D003404:Creatinine; D001379:Azathioprine; D011241:Prednisone