title: Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
abstract: The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects; D004926:Escherichia coli / Q000032:analysis; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D008070:Lipopolysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D008934:Mitogens / Q000494:pharmacology*; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification / Q000494:pharmacology*; D012475:Salmonella / Q000032:analysis; D012710:Serum Albumin, Bovine; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D008934:Mitogens; D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine