title: Iron-binding catechols and virulence in Escherichia coli.
abstract: A comparison of viral-induced unresponsiveness of phytohemagglutinin (PHA)-induced deoxyribonucleic acid (DNA) synthesis of mouse lymphocytes was made by culturing the cells under identical conditions in the presence of HEPES buffer in a humid-air atmosphere. The degree of PHA-induced DNA synthesis was found to vary, depending upon the type of ribonucleic acid or DNA virus treatment. Myxovirus, paramyxoviruses, Mengo virus, leukemic viruses, herpesvirus, and vaccinia virus caused a depression in responsiveness, whereas lactic dehydrogenase virus, adenovirus, and polyoma virus induced an increase in DNA synthesis. Inhibition of DNA synthesis was significant only if the virus was added at 0 h or within the first 12 h after PHA stimulation. Time studies indicated that leukemic and nonleukemic viruses caused similar patterns in the alteration of PHA-induced DNA synthesis.
mesh_terms: D000818:Animals; D002396:Catechols / Q000096:biosynthesis* / Q000378:metabolism; D002614:Chelating Agents / Q000378:metabolism; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D006736:Horses / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007501:Iron / Q000378:metabolism*; D008297:Male; D051379:Mice; D014168:Transferrin / Q000378:metabolism*; D014774:Virulence
chemical_list: D002396:Catechols; D002614:Chelating Agents; D007106:Immune Sera; D014168:Transferrin; D007501:Iron