Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.
Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial. Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.
D000328:Adult; D002986:Clinical Trials as Topic; D004035:Diet Therapy; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006801:Humans; D008041:Linoleic Acids / Q000627:therapeutic use*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy*; D009821:Oils / Q000627:therapeutic use; D009829:Oleic Acids / Q000627:therapeutic use; D010973:Platelet Adhesiveness; D012008:Recurrence; D013997:Time Factors
D005227:Fatty Acids; D008041:Linoleic Acids; D009821:Oils; D009829:Oleic Acids