Enhanced immune response after immunosuppression by Streptococcal pyrogenic exotoxin.
Streptococcal pyrogenic exotoxin (SPE) was shown previously to be a potent immunosuppressant. This paper presents data documenting that immunosuppression frequently was followed by elevated antibody and plaque-forming cell levels as noted in our earlier report. The data are interpreted as a differential effect of SPE upon suppressor T cells and secreting B cells.
D000917:Antibody Formation; D000921:Antibody-Producing Cells; D007165:Immunosuppression Therapy; D013297:Streptococcus pyogenes / Q000378:metabolism*; D014118:Toxins, Biological
D014118:Toxins, Biological