Resistance to arbovirus challenge in mice immediately after vaccination.
Mice vaccinated with a single injection of formalin-inactivated suspensions of mouse brain tissue infected with arboviruses were markedly protected against a challenge injection administered hours later. The protection observed during the first 2 days after vaccination seemed to be nonspecific, in that it appeared not only with the homologous system but also between arboviruses of different antigenic groups; this phase may be associated with an interferon-like activity of the serum. Overlapping the nonspecific phase was one of specific protection, which seemed to be well-established in its own right by day 3 or 4 after vaccination. Serum neutralizing antibodies against the homologous viruses were detected as early as 24 h after vaccination and in almost all instances by day 3.
D000818:Animals; D001102:Arbovirus Infections / Q000276:immunology*; D002478:Cells, Cultured; D003429:Cross Reactions; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology; D004668:Encephalitis Viruses / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007117:Immunization, Secondary; D007372:Interferons / Q000032:analysis; D051379:Mice; D008815:Mice, Inbred Strains; D009500:Neutralization Tests; D013997:Time Factors; D014611:Vaccination; D014765:Viral Vaccines
D014765:Viral Vaccines; D007372:Interferons