title: Necrotizing enterocolitis--a medical approach to treatment.
abstract: Ten cases of necrotizing enterocolitis occurred among 5400 infants delivered consecutively during a two and one-half year period at the Halifax Infirmary. Since this disease involved such extensive areas of the intestinal wall, medical management was employed exclusively, even when intestinal perforation occurred. Nine of the ten infants survived.In this series there was a high incidence of prematurity, prolonged interval between rupture of the placental membranes and delivery, severe asphyxia neonatorum and subsequent hypotension and metabolic acidosis. Blood cultures grew Klebsiella aerobacter or E. coli in 7/10 infants. Only two of these organisms were sensitive to kanamycin and all were resistant to ampicillin. Administration of ampicillin to the mothers did not protect these infants against necrotizing enterocolitis. Edema of the gut wall appeared to be an important early sign. Stricture formation occurred in 4/10 cases, all in the terminal ileum. These infants were operated upon only after the acute stage of the disease had subsided.
mesh_terms: D000138:Acidosis / Q000188:drug therapy; D000667:Ampicillin / Q000627:therapeutic use; D001724:Birth Weight; D001769:Blood / Q000382:microbiology; D001803:Blood Transfusion; D004761:Enterocolitis, Pseudomembranous / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D004926:Escherichia coli; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D007612:Kanamycin / Q000627:therapeutic use; D007709:Klebsiella; D010403:Penicillin Resistance; D011247:Pregnancy; D011859:Radiography
chemical_list: D007612:Kanamycin; D000667:Ampicillin