Induction of tolerance to sheep red blood cells.
Adult mice injected with a sheep red blood cell hemolysate supernatant fraction were found to have a severely reduced responsiveness to subsequent immunization with sheep red blood cells. The induced unresponsiveness was found to be specific, as tested by reciprocal experiments involving horse and sheep erythrocyte preparations. The tolerogenic material did not appear to be immunogenic.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D051379:Mice; D012756:Sheep
D003520:Cyclophosphamide