Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters.
D000814:Aniline Compounds / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002474:Cell-Free System; D003864:Depression, Chemical; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005492:Folic Acid / Q000096:biosynthesis*; D005493:Folic Acid Antagonists / Q000494:pharmacology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D011621:Pteridines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology*
D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D005493:Folic Acid Antagonists; D011621:Pteridines; D011725:Pyridines; D013449:Sulfonamides; D005492:Folic Acid