Neuroanatomical correlates of morphine dependence.
Naloxone hydrochloride, an opioid antagonist, was applied to several discrete brain regions of morphine-dependent rats to precipitate abstinence. Severe withdrawal signs were elicited after administration in the thalamus but not in neocortical, hippocampal, hypothalamic, or tegmental areas of the brain.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D004027:Diencephalon / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology; D009021:Morphine Dependence; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D013238:Stereotaxic Techniques; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced; D013788:Thalamus / Q000187:drug effects
D009019:Morphinans; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine