Natural and immune antibodies for Vibrio fetus in serum and secretions of cattle.
Naturally occurring antibodies for Vibrio fetus with whole-cell and O antigen specificities were detected in sera of mature cattle by means of the agglutination and indirect immunofluorescence reactions. O antibodies occurred in each of 21 sera examined, and whole-cell antibodies, in lower concentrations, occurred in 15 of the 21 sera. Natural antibodies were detected in the immunoglobulin G, M, and A (IgG, IgM, IgA) classes. Parenteral immunization with whole cells in Freund's complete adjuvant caused an increase in antibodies, predominantly IgG, with both whole-cell and O specificities; genital infection produced minimal alterations in levels of serum antibody. O antibodies, predominantly of the IgA class, occurred in nasal secretions of most of these animals but only infrequently in saliva or tears. Nasal secretion titers of O antibodies fluctuated widely from week to week but appeared to be unaffected by parenteral immunization or experimental infection. It is hypothesized that the nasal passages serve as a site of antigenic stimulation and synthesis of naturally occurring V. fetus antibodies.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis*; D002168:Campylobacter fetus / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000196:embryology; D002850:Chromatography, Gel; D005260:Female; D005455:Fluorescent Antibody Technique; D006384:Hemagglutination; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D009297:Nasal Mucosa / Q000276:immunology; D012463:Saliva / Q000276:immunology; D013666:Tears / Q000276:immunology; D013997:Time Factors; D014733:Vibrio / Q000276:immunology*; D014735:Vibrio Infections / Q000276:immunology / Q000662:veterinary
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G