Chylomicrons and the formation of foam cells in type I hyperlipoproteinemia. A morphologic study.
Light and electron microscopic study of aspirated bone marrow of a patient with type I hyperlipoproteinemia disclosed large, birefringent foam cells which develop from phagocytosis of chylomicrons by histiocytes. Chylomicrons are taken up, singly and in aggregates, by infoldings of the plasma membranes of histiocytes; these infoldings become phagocytic vacuoles within the cytoplasm. As chylomicrons are metabolized, the foam cells decrease in size, lose birefringence and develop autofluorescent, electron-dense deposits of ceroid.
D000328:Adult; D001718:Birefringence; D001796:Blood Protein Disorders / Q000473:pathology*; D001853:Bone Marrow; D001854:Bone Marrow Cells; D002784:Cholesterol / Q000097:blood; D002914:Chylomicrons / Q000378:metabolism*; D003594:Cytoplasmic Granules; D006056:Golgi Apparatus; D006644:Histiocytes; D006651:Histocytochemistry; D006801:Humans; D006949:Hyperlipidemias / Q000473:pathology*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D010587:Phagocytosis; D010860:Pigments, Biological / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D002914:Chylomicrons; D008074:Lipoproteins; D010860:Pigments, Biological; D014280:Triglycerides; D002784:Cholesterol