Initiation and termination of bacterial deoxyribonucleic acid replication in low concentrations of chloramphenicol.
Escherichia coli 15T(-) can initiate a cycle of deoxyribonucleic acid replication with equal efficiency in the presence of 25 or 50 mug of chloramphenicol/ml. However, these replication cycles are not completed in the presence of these drug concentrations, and the amount of replication decreases with increasing drug concentration.
D000596:Amino Acids / Q000378:metabolism; D000643:Ammonium Chloride / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D002701:Chloramphenicol / Q000494:pharmacology*; D003470:Culture Media; D004261:DNA Replication / Q000187:drug effects*; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D013941:Thymine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D000596:Amino Acids; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003470:Culture Media; D004269:DNA, Bacterial; D000643:Ammonium Chloride; D014316:Tritium; D002701:Chloramphenicol; D005947:Glucose; D013941:Thymine