title: Precursor and product in bacteriophage lambda recombination.
abstract: Analyses of the time of recombination in bacteria infected with phage lambda and in spheroplasts infected with purified phage lambda DNA indicate a preponderance of recombination occurring before replication ("early recombination") after infection with tandem dimers formed in vitro compared to linear monomer DNA and phage infections. Among the early recombinants is a large fraction of cells that produces one recombinant type exclusively. Two suggestions are discussed-that a dimer-like molecule is the precursor of the recombinant progeny molecule and that one recombinant chromosome is the frequent or exclusive product of a recombinational event.
mesh_terms: D002499:Centrifugation, Density Gradient; D003090:Coliphages / Q000032:analysis / Q000378:metabolism*; D004261:DNA Replication; D004279:DNA, Viral / Q000032:analysis; D004926:Escherichia coli / Q000378:metabolism; D008242:Lysogeny; D008970:Molecular Weight; D011995:Recombination, Genetic; D013104:Spheroplasts; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D014316:Tritium; D013936:Thymidine