Nonspecific protective action against Vibrio cholerae of SK&F 42319, a ribonucleic acid obtained from bacteriophage-infected Escherichia coli.
An interferon-inducing RNA, SK&F 42319, obtained from a lysate of phage-infected Escherichia coli, protected mice against Vibrio cholerae infection. This nonspecific protection was not attributable to endotoxin contamination.
D000818:Animals; D001435:Bacteriophages; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli / Q000378:metabolism*; D007369:Interferon Inducers / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D012329:RNA, Bacterial / Q000494:pharmacology*; D014366:Tryptophan Oxygenase / Q000378:metabolism; D014733:Vibrio / Q000276:immunology*; D014735:Vibrio Infections / Q000276:immunology
D004731:Endotoxins; D007369:Interferon Inducers; D012329:RNA, Bacterial; D014366:Tryptophan Oxygenase