title: Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences.
mesh_terms: D000105:Acetyl Coenzyme A; D001665:Binding Sites; D001667:Binding, Competitive; D002208:Caproates; D002247:Carbon Isotopes; D002850:Chromatography, Gel; D003956:Dialysis; D004591:Electrophoresis, Polyacrylamide Gel; D005246:Feedback; D006863:Hydrogen-Ion Concentration; D007651:Keto Acids; D007700:Kinetics; D007930:Leucine; D008293:Malates; D009154:Mutation; D007652:Oxo-Acid-Lyases / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D011487:Protein Conformation; D012486:Salmonella typhimurium / Q000201:enzymology*; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D014631:Valerates
chemical_list: D002208:Caproates; D002247:Carbon Isotopes; D007651:Keto Acids; D008293:Malates; D014631:Valerates; D000105:Acetyl Coenzyme A; D007652:Oxo-Acid-Lyases; D007930:Leucine