title: Trimethoprim-sulfamethoxazole: pharmacodynamic effects of urinary pH and impaired renal function. Studies in humans.
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000284:Administration, Oral; D000643:Ammonium Chloride / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D001639:Bicarbonates / Q000008:administration & dosage; D001798:Blood Proteins; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D005470:Fluorometry; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D011743:Pyrimidines / Q000378:metabolism*; D013420:Sulfamethoxazole / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014295:Trimethoprim / Q000008:administration & dosage / Q000097:blood / Q000652:urine; D014462:Ultrafiltration
chemical_list: D000900:Anti-Bacterial Agents; D001639:Bicarbonates; D001798:Blood Proteins; D004338:Drug Combinations; D011743:Pyrimidines; D000643:Ammonium Chloride; D014295:Trimethoprim; D013420:Sulfamethoxazole