In-vivo cytogenetic effects of perphenazine and chlorpromazine: a negative study.
No evidence was found that either perphenazine or chlorpromazine induced chromosomal damage in patients given the drugs. These results were reached independently at two separate laboratories; earlier reports of possible adverse cytogenetic effects of these drugs can probably be discounted.
D000328:Adult; D002746:Chlorpromazine / Q000009:adverse effects* / Q000494:pharmacology; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008875:Middle Aged; D008938:Mitosis / Q000187:drug effects; D010546:Perphenazine / Q000009:adverse effects* / Q000494:pharmacology; D013223:Statistics as Topic
D010546:Perphenazine; D002746:Chlorpromazine