Adjuvant activity of Mycobacterium leprae.
Mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. Histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of M. leprae and much smaller amounts after the injection of M. tuberculosis.
D000276:Adjuvants, Immunologic; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007106:Immune Sera; D008099:Liver / Q000382:microbiology; D009166:Mycobacterium leprae / Q000276:immunology* / Q000302:isolation & purification; D010047:Ovalbumin; D013154:Spleen / Q000382:microbiology
D000276:Adjuvants, Immunologic; D000906:Antibodies; D000941:Antigens; D007106:Immune Sera; D010047:Ovalbumin