Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness.
Recombinational polarity and suppressiveness are two well-known but puzzling cytoplasmic genetic phenomena in bakers' yeast, Saccharomyces cerevisiae. Little progress has been made in characterizing the underlying molecular mechanisms of these phenomena. In this paper we describe a molecular model for recombinational polarity that is compatible with the available genetic evidence. The model stresses the role of small deletions and excision/repair processes in otherwise canonical recombinational events. According to the model, both phenomena require recombination and may share mechanistic elements.
D003433:Crosses, Genetic; D004272:DNA, Mitochondrial / Q000378:metabolism; D005111:Extrachromosomal Inheritance; D005838:Genotype; D008954:Models, Biological; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013489:Suppression, Genetic
D004272:DNA, Mitochondrial