Partial similarities between yeast and liver alcohol dehydrogenases.
The primary structure of about half of the protein chain of yeast alcohol dehydrogenase has been determined and compared with the amino-acid sequences of other dehydrogenases. The enzyme is found to be distantly related to horse-liver alcohol dehydrogenase, although these two proteins have different quaternary structures and subunit sizes. Some regions show no significant similarities, but long segments within the N-terminal parts of the molecules are homologous, suggesting a common and important function for these segments. Ancestral connections between some different dehydrogenases can be concluded and the degree of evolutionary changes may be estimated.
D000429:Alcohol Oxidoreductases; D000595:Amino Acid Sequence; D000818:Animals; D005969:Glutamate Dehydrogenase; D006736:Horses; D007770:L-Lactate Dehydrogenase; D008099:Liver / Q000201:enzymology*; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000201:enzymology*
D000429:Alcohol Oxidoreductases; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase