A photo-induced reaction of chloramphenicol with E. coli ribosomes: covalent binding of the antibiotic and inactivation of peptidyl transferase.
D001665:Binding Sites; D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000378:metabolism* / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007553:Isotope Labeling; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D011955:Receptors, Drug / Q000187:drug effects*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D002250:Carbon Radioisotopes; D011955:Receptors, Drug; D004917:Erythromycin; D002701:Chloramphenicol; D010453:Peptide Synthases