title: Variability in response to drugs.
abstract: Variability in the response to drugs is due to three principal components-the disease, the responsiveness of tissues, and the concentration of the drug at its site of action (as reflected by its plasma concentration). The relative contributions of these components will differ not only for different drugs but also for different effects of the same drug. Rational drug therapy depends on knowledge of all three factors.
mesh_terms: D000208:Acute Disease; D000215:Acylation; D002752:Chlorthalidone / Q000627:therapeutic use; D002908:Chronic Disease; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D003981:Diazoxide / Q000627:therapeutic use; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009404:Nephrotic Syndrome / Q000209:etiology; D009638:Norepinephrine / Q000378:metabolism; D009661:Nortriptyline / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity; D010084:Oxidation-Reduction; D010670:Phenylthiourea / Q000008:administration & dosage; D012701:Serotonin / Q000378:metabolism; D013148:Spironolactone / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use
chemical_list: D013256:Steroids; D013148:Spironolactone; D012701:Serotonin; D010670:Phenylthiourea; D004077:Digoxin; D009661:Nortriptyline; D003981:Diazoxide; D002752:Chlorthalidone; D009638:Norepinephrine