Tumor development after 3-methylcholanthrene in immunologically deficient athymic-nude mice.
Athymic-nude (nu/nu) mice and normal (nu/+) mice showed no differences in either latent period or incidence of local sarcomas or lung adenomas within 120 days after administration of 3-methylcholanthrene at birth. However, nu/nu mice were incapable of rejecting allogeneic skin grafts for the duration of the experiment. These results argue against an active role of thymus-dependent immunity as a surveillance mechanism preventing tumor development.
D000236:Adenoma / Q000139:chemically induced / Q000276:immunology; D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000276:immunology; D006084:Graft Rejection; D007153:Immunologic Deficiency Syndromes / Q000151:congenital / Q000276:immunology*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology; D012737:Sex Factors; D016038:Skin Transplantation; D013950:Thymus Gland / Q000276:immunology*; D013997:Time Factors; D014184:Transplantation, Homologous
D008748:Methylcholanthrene