title: Bacterial cell division regulation: characterization of the dnaH locus of Escherichia coli.
abstract: The dnaH locus is the fourth gene to be identified as required for deoxyribonucleic acid polymerization in Escherichia coli. A temperature-sensitive mutant defective in this gene exhibited an abrupt decrease in rate of deoxyribonucleic acid synthesis when shifted to 42 C. The locus mapped in the proC-purE region of the chromosome by conjugation and was co-transducible with purE. dnaH(+) is carried on the F'(13) episome and is dominant over the dnaH(-) mutation.
mesh_terms: D002455:Cell Division; D002874:Chromosome Mapping; D003227:Conjugation, Genetic; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis*; D003854:Deoxyribonucleotides / Q000378:metabolism; D004926:Escherichia coli / Q000166:cytology / Q000378:metabolism*; D005796:Genes; D005799:Genes, Dominant; D008854:Microscopy, Electron; D009154:Mutation; D010761:Phosphorus Radioisotopes; D012329:RNA, Bacterial / Q000096:biosynthesis; D013696:Temperature; D013936:Thymidine / Q000378:metabolism; D014161:Transduction, Genetic; D014316:Tritium; D014498:Uracil / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D003854:Deoxyribonucleotides; D010761:Phosphorus Radioisotopes; D012329:RNA, Bacterial; D014316:Tritium; D014498:Uracil; D013936:Thymidine