title: Potential antileprotic agents. 2. Inhibition of mycobacterial dihydrofolic reductase.
mesh_terms: D000630:Aminopterin / Q000494:pharmacology; D005493:Folic Acid Antagonists; D007700:Kinetics; D007918:Leprosy / Q000188:drug therapy*; D008727:Methotrexate / Q000494:pharmacology; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000201:enzymology; D011485:Protein Binding / Q000187:drug effects; D011621:Pteridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D011739:Pyrimethamine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D005493:Folic Acid Antagonists; D011621:Pteridines; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D000630:Aminopterin; D008727:Methotrexate; D011739:Pyrimethamine