Unfolding of the host genome after infection of Escherichia coli with bacteriophage T4.
The folded genome of Escherichia coli is converted to a slower-sedimenting form within 5 min after infection with bacteriophage T4 or T4nd28(den A)-amN82(44). Chloramphenicol sensitivity and response to UV-irradiation of the phage suggest participation of viral-induced functions.
D002250:Carbon Radioisotopes; D002499:Centrifugation, Density Gradient; D002701:Chloramphenicol / Q000494:pharmacology; D003090:Coliphages / Q000254:growth & development* / Q000528:radiation effects; D004269:DNA, Bacterial / Q000032:analysis / Q000378:metabolism*; D004926:Escherichia coli / Q000032:analysis / Q000378:metabolism*; D009691:Nucleic Acid Denaturation; D011830:Radiation Effects; D013936:Thymidine; D014316:Tritium; D014466:Ultraviolet Rays; D014783:Viscosity
D002250:Carbon Radioisotopes; D004269:DNA, Bacterial; D014316:Tritium; D002701:Chloramphenicol; D013936:Thymidine