Acute lymphoblastic leukemic cells with T (thymus-derived) lymphocyte markers.
Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker for B (bone marrow or bursa-equivalent) cells, that is, the presence of surface immunoglobulins.
D000293:Adolescent; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006041:Goats / Q000276:immunology; D006801:Humans; D007104:Immune Adherence Reaction; D007223:Infant; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008297:Male; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D003165:Complement System Proteins