title: Mutants of group D1 Salmonella carrying the somatic antigen of group A organisms: isolation and serological characterization.
abstract: O antigen mutants were obtained from Salmonella durban, a group D(1) organism, by treatment with N-methyl-N'-nitro-N-nitrosoguanidine. Serological studies demonstrated that the mutants lost the O-9 antigen factor of the parent organism but acquired the O-2 factor specific to group A Salmonella. Lipopolysaccharides of the mutant strains contained paratose which determines the specificity of O-2 factor. Tyvelose, present in the wild-type lipopolysaccharide, was not found in the mutants. H antigens and other biological characteristics of the mutant strains were the same as those of the wild-type organism. The present finding implies that group A Salmonella species might be derived from group D(1) organisms.
mesh_terms: D000372:Agglutination Tests; D000942:Antigens, Bacterial / Q000032:analysis* / Q000302:isolation & purification; D002854:Chromatography, Paper; D006601:Hexoses / Q000032:analysis; D008070:Lipopolysaccharides / Q000032:analysis / Q000302:isolation & purification; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D011135:Polysaccharides, Bacterial / Q000032:analysis / Q000302:isolation & purification; D012475:Salmonella / Q000145:classification / Q000276:immunology*; D012482:Salmonella paratyphi A / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D012703:Serotyping; D013045:Species Specificity
chemical_list: D000942:Antigens, Bacterial; D006601:Hexoses; D008070:Lipopolysaccharides; D009153:Mutagens; D009604:Nitrosoguanidines; D011135:Polysaccharides, Bacterial