Thymidine-dependent Escherichia coli infection and some associated laboratory problems.
The rapid emergence of a thymidine-dependent strain of Escherichia coli in a patient treated with co-trimoxazole is described. The organism was recovered from blood cultures during a septicaemia which developed after only a few days of co-trimoxazole treatment. The cultural characteristics of three thymidine-dependent strains were studied and a remarkable variation was found in their ability to grow on different batches of blood agar, depending upon the age of the plates and the type of agar base used.
D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D001769:Blood / Q000382:microbiology; D003470:Culture Media; D004338:Drug Combinations; D004926:Escherichia coli / Q000254:growth & development / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006417:Hematuria; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000627:therapeutic use; D011507:Proteinuria; D011704:Pyelonephritis / Q000150:complications; D018805:Sepsis / Q000209:etiology; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013936:Thymidine; D013941:Thymine; D014295:Trimethoprim / Q000627:therapeutic use
D003470:Culture Media; D004338:Drug Combinations; D000667:Ampicillin; D009582:Nitrofurantoin; D014295:Trimethoprim; D013420:Sulfamethoxazole; D013941:Thymine; D013936:Thymidine