Inhibition of RNA chain initiation in E. coli core RNA polymerase with 2-hydroxy-5-nitrobenzyl bromide.
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D001665:Binding Sites; D002417:Cattle; D003545:Cysteine; D003597:Cytosine Nucleotides / Q000378:metabolism; D004247:DNA; D004269:DNA, Bacterial; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D007461:Iodoacetates; D008837:Micrococcus; D009574:Nitro Compounds / Q000494:pharmacology*; D010761:Phosphorus Radioisotopes; D011485:Protein Binding; D011487:Protein Conformation; D013698:Templates, Genetic; D013950:Thymus Gland; D014158:Transcription, Genetic / Q000187:drug effects*; D014316:Tritium; D014364:Tryptophan
D001593:Benzyl Compounds; D003597:Cytosine Nucleotides; D004269:DNA, Bacterial; D007461:Iodoacetates; D009574:Nitro Compounds; D010761:Phosphorus Radioisotopes; D014316:Tritium; D014364:Tryptophan; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D003545:Cysteine