Mode of action of lividomycin on protein synthesis in Escherichia coli.
Lividomycin specifically inhibited bacterial protein synthesis and had codon misreading activity. Lividomycin, moreover, stimulated the binding of aminoacyl-transfer ribonucleic acid to ribosomes, but did not show any significant effects on the formation of aminoacyl-transfer ribonucleic acid and the puromycin reaction.
D000596:Amino Acids / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D002474:Cell-Free System; D004926:Escherichia coli / Q000378:metabolism*; D005815:Genetic Code; D010303:Paromomycin / Q000494:pharmacology*; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects; D010649:Phenylalanine / Q000378:metabolism; D011072:Poly U / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D012343:RNA, Transfer / Q000096:biosynthesis; D012270:Ribosomes / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014498:Uracil / Q000378:metabolism
D000596:Amino Acids; D001426:Bacterial Proteins; D002250:Carbon Radioisotopes; D014316:Tritium; D011072:Poly U; D010649:Phenylalanine; D014498:Uracil; D010303:Paromomycin; D012343:RNA, Transfer; D013936:Thymidine