title: Reversible blocking of DNA transcription of E. coli DNA dependent RNA polymerase with thiopyrimidine nucleotides.
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002417:Cattle; D002850:Chromatography, Gel; D004247:DNA; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D046911:Macromolecular Substances; D010761:Phosphorus Radioisotopes; D011485:Protein Binding; D012293:Rifampin / Q000494:pharmacology; D013698:Templates, Genetic; D013891:Thiouridine / Q000494:pharmacology; D013950:Thymus Gland; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects*; D014316:Tritium; D014500:Uracil Nucleotides / Q000494:pharmacology*
chemical_list: D046911:Macromolecular Substances; D010761:Phosphorus Radioisotopes; D014500:Uracil Nucleotides; D014316:Tritium; D013891:Thiouridine; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin