Combined T and B cell acute lymphoblastic leukaemia.
A case of acute lymphoblastic leukaemia in a 17-year-old male is described. The patient had many distinctive features including a very high blast cell count, prominent lymphadenopathy and hepatosplenomegaly, thymic mass, and a fulminant clinical course. Immunological studies on the blast cells using a variety of techniques showed the presence of two distinct subpopulations, one having the surface characteristics of thymus-dependent (T) lymphoid cells and the other those of bursa-equivalent (B) lymphoid cells. The case therefore represents the first example of a combined T and B cell acute leukaemia.
D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001772:Blood Cell Count; D002118:Calcium / Q000097:blood; D003298:Coombs Test; D004912:Erythrocytes; D005455:Fluorescent Antibody Technique; D006529:Hepatomegaly / Q000150:complications; D006801:Humans; D007104:Immune Adherence Reaction; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012756:Sheep; D013163:Splenomegaly / Q000150:complications; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000503:physiopathology; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D000493:Allopurinol; D002118:Calcium; D011241:Prednisone