Aging increases susceptibility of mouse skin to DMBA carcinogenesis independent of general immune status.
The dependence of chemical carcinogenesis on age of target tissue was studied by repeated DMBA-treatment of mouse skin grafted from old and young syngeneic donors to young recipients. Carcinomas developed on 39 percent (1.6/41) of grafts from old donors and on 12 percent (5/41) of grafts from young donors. The incidence of nonskin lymphoid tumors was highest in male recipients bearing grafts from old donors.
D000367:Age Factors; D000375:Aging; D000818:Animals; D001551:Benz(a)Anthracenes; D002277:Carcinoma / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D007945:Leukemia, Lymphoid / Q000276:immunology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010212:Papilloma / Q000139:chemically induced* / Q000276:immunology; D012737:Sex Factors; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000276:immunology; D016038:Skin Transplantation; D014019:Tissue Donors; D014184:Transplantation, Homologous
D001551:Benz(a)Anthracenes