The influence of DL-A compatibility on the survival of hepatic allografts in unmodified mongrel dogs.
Heterotopic hepatic transplantation was performed in 26 pairs of littermate and non-littermate mongrel dogs selected by serological criteria of DL-A compatibility. No immunosuppression was given. In non-littermates, 11 recipients of DL-A incompatible allografts survived 10-22 days (mean 13.4 days). Mean serum bilirubin rose by the 6th day. Three recipients of DL-A compatible allografts survived 13, 41, and 60 days, (mean 38 days). Mean serum bilirubin rose by the 8th day. In littermates, 5 recipients of DL-A incompatible allografts survived 7-12 days (mean 10.2 days) and mean serum bilirubin rose by the 6th day. Four recipients of DL-A compatible allografts from phenotypically DL-A non-identical donors survived 58, 82, 90 and 128 days (mean 89.5 days). Mean serum bilirubin rose by the 29th day. In contrast, 3 recipients of DL-A phenotypically identical allografts survived 171, 536 and over 636 days respectively, with normal mean serum bilirubin levels. The results confirm the role of the DL-A system in hepatic transplantation in mongrel dogs, and suggest that this dog population may constitute a suitable experimental model parallelling the current situation with regard to HL-A compatibility testing in outbred human subjects. The relatively long survival of DL-A compatible heterotopic hepatic allografts, compared with similar transplants of skin, kidney and heart, also suggests a need for studies of possible alteration in parameters of humoral and cellular reactivity in these recipients.
D000818:Animals; D000941:Antigens / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D001787:Blood Group Incompatibility; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000601:surgery; D003601:Cytotoxicity Tests, Immunologic; D004386:Duodenum / Q000601:surgery; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005704:Gallbladder / Q000601:surgery; D006084:Graft Rejection; D006648:Histocompatibility; D006649:Histocompatibility Antigens / Q000032:analysis*; D016031:Liver Transplantation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008722:Methods; D009392:Nephrectomy; D010641:Phenotype; D012737:Sex Factors; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000941:Antigens; D006649:Histocompatibility Antigens; D001663:Bilirubin