Effect of oral tetracycline on the occurrence of tetracycline-resistant strains of Escherichia coli in the intestinal tract of humans.
Serial samples of feces from normal human subjects were analyzed for tetracycline-resistant strains of Escherichia coli. Subjects were found to be excreting tetracycline-resistant strains in amounts fluctuating with time. Ingestion of tetracycline increased both the number of individuals excreting tetracycline-resistant strains of E. coli and the proportion of the total E. coli isolates resistant to the antibiotic.
D000284:Administration, Oral; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology*; D006801:Humans; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013752:Tetracycline