Macrophage-dependent lymphocyte immunostimulation in cattle infected with Mycobacterium bovis and with Mycobacterium avium.
Cultures of bovine peripheral blood leukocytes were prepared from calves inoculated with Mycobacterium bovis and with M. avium. Suitable lymphocyte stimulation was obtained with specific and nonspecific mycobacterial mitogens. Leukocyte cultures depleted of adherent, macrophage-type cells did not respond to stimulation with purified protein derivative, although they were responsive to phytohemagglutinin.
D000818:Animals; D000942:Antigens, Bacterial; D002417:Cattle; D002448:Cell Adhesion; D002469:Cell Separation; D002478:Cells, Cultured; D003429:Cross Reactions; D037102:Lectins; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D014373:Tuberculin
D000942:Antigens, Bacterial; D037102:Lectins; D014373:Tuberculin