title: A controlled field trial on the effectiveness of the intradermal and subcutaneous administration of cholera vaccine in the Philippines.
abstract: In view of the encouraging laboratory findings on the efficacy of intradermal administration of cholera vaccination in small doses, a controlled field trial was undertaken in the Philippines to evaluate the efficacy of the two routes for cholera vaccination. The trial has shown that these routes are effective, both giving a significant degree of protection against cholera. However, the vaccine afforded longer-lasting protection when administered subcutaneously (6 months) than when given intradermally (4 months), and was significantly more effective in children in the 1-5-year age group in this endemic area.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D010679:Philippines; D014436:Typhoid-Paratyphoid Vaccines; D014611:Vaccination
chemical_list: D022121:Cholera Vaccines; D014436:Typhoid-Paratyphoid Vaccines