title: R-factor trimethoprim resistance mechanism: an insusceptible target site.
mesh_terms: D002850:Chromatography, Gel; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D008970:Molecular Weight; D013056:Spectrophotometry, Ultraviolet; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis*; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: C006094:R388; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase