A controlled field trial on the effectiveness of the intradermal and subcutaneous administration of cholera vaccine in the Philippines.
In view of the encouraging laboratory findings on the efficacy of intradermal administration of cholera vaccination in small doses, a controlled field trial was undertaken in the Philippines to evaluate the efficacy of the two routes for cholera vaccination. The trial has shown that these routes are effective, both giving a significant degree of protection against cholera. However, the vaccine afforded longer-lasting protection when administered subcutaneously (6 months) than when given intradermally (4 months), and was significantly more effective in children in the 1-5-year age group in this endemic area.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D010679:Philippines; D014436:Typhoid-Paratyphoid Vaccines; D014611:Vaccination
D022121:Cholera Vaccines; D014436:Typhoid-Paratyphoid Vaccines