Statistical analysis of data bearing on the number of particles required to form a plaque.
Methods of statistical analysis are presented for one or more dilution series experiments where the quantity of interest is the number of virus particles required to infect a cell. These methods are illustrated on several data sets drawn from the literature. Data from seven series, which have been used to support a two-particle model in the literature, are here shown to reject such a model decisively, whereas fifteen other experiments are found to be in excellent agreement with a one-particle model.
D006462:Hemolytic Plaque Technique; D008954:Models, Biological; D013223:Statistics as Topic / Q000379:methods; D014780:Viruses / Q000472:pathogenicity