title: Design and implementation of early clinical trials.
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004282:Documentation; D004341:Drug Evaluation; D006077:Government Agencies; D006805:Human Experimentation; D006801:Humans; D007258:Informed Consent; D008722:Methods; D012107:Research Design; D012108:Research Personnel / Q000600:supply & distribution; D014481:United States; D014486:United States Food and Drug Administration