Beta cell protection to alloxan necrosis by anomers of D-glucose.
Various concentrations of either the alpha or beta anomers of D-glucose were injected into fasted rats prior to a diabetogenic dose of alloxan. Plasma concentrations of glucose were measured 24 hours later. There was a significantly greater protection of the pancreatic beta cells by the alpha anomer of D-glucose as compared to the beta anomer, which was evidenced by concentrations of glucose in the plasma, and morphology of beta cells.
D000496:Alloxan / Q000037:antagonists & inhibitors*; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D005947:Glucose / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects; D008297:Male; D009336:Necrosis / Q000517:prevention & control*; D051381:Rats; D013237:Stereoisomerism
D000496:Alloxan; D005947:Glucose