The reactivities of isomers of dichlorodiammine-platinum (II) with dehydrogenase enzymes. Evidence for inhibition via cross-linkage.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004355:Drug Stability; D004589:Electrophoresis, Disc; D000431:Ethanol; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors*; D009206:Myocardium / Q000201:enzymology; D010984:Platinum / Q000494:pharmacology*; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013696:Temperature
D000431:Ethanol; D010984:Platinum; D000429:Alcohol Oxidoreductases; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase