Infectious agammaglobulinemia: transmission of immunodeficiency with grafts of agammaglobulinemic cells.
Agammaglobulinemia induced in chickens by surgical bursectomy and irradiation at hatching is transmissible at 4 mo of age to sublethally irradiated normal chickens by bone marrow transplantation. The immunodeficiency which develops in the recipients persists for life and is characterized by inability to produce antibody and by progressive loss of detectable serum IgM and IgG.
D000361:Agammaglobulinemia / Q000209:etiology / Q000276:immunology / Q000635:transmission*; D000818:Animals; D000917:Antibody Formation; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D002060:Bursa of Fabricius / Q000276:immunology; D002645:Chickens; D006433:Hemocyanins / Q000276:immunology; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D008974:Mollusca / Q000276:immunology; D011828:Radiation Chimera; D014184:Transplantation, Homologous
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D006433:Hemocyanins