Quinazolines. 12. 1,3-Diaminobenzo(f)quinazolines containing long-chain alkyl or chloro substituents on the central ring. Synthesis and biological evaluation as candidate antifolate and antimalarial agents.
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D002277:Carcinoma; D002460:Cell Line; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D009062:Mouth Neoplasms; D010376:Pediococcus / Q000187:drug effects / Q000254:growth & development; D010962:Plasmodium berghei; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship
D000962:Antimalarials; D005493:Folic Acid Antagonists; D011799:Quinazolines