title: Comparative trial of pancrex V forte and nutrizym in treatment of malabsorption in cystic fibrosis.
abstract: A cross-over trial of pancreatic enzyme replacement therapy has been conducted on 12 children with cystic fibrosis using Pancrex V forte and Nutrizym tablets in equivalent dosage. No differences were found in the effectiveness of these products as measured by stool volume, number of bowel actions, faecal fat excretion, and urine urea excretion. Neither product eliminated the steatorrhoea. Though there was no laboratory evidence to support their choice nine patients expressed a preference for Nutrizym at the conclusion of the trial. This preference was based partly on the smaller number of tablets which are required.
mesh_terms: D000293:Adolescent; D000681:Amylases / Q000627:therapeutic use*; D001963:Bromelains / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000150:complications*; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D004338:Drug Combinations; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008049:Lipase / Q000627:therapeutic use*; D008055:Lipids / Q000032:analysis; D008286:Malabsorption Syndromes / Q000188:drug therapy*; D008297:Male; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D010194:Pancreatin; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D014357:Trypsin / Q000627:therapeutic use*; D014508:Urea / Q000652:urine
chemical_list: D004041:Dietary Fats; D004044:Dietary Proteins; D004338:Drug Combinations; D008055:Lipids; D010184:Pancreatic Extracts; C008762:Pancrex V; D010194:Pancreatin; D014508:Urea; D001963:Bromelains; D008049:Lipase; D000681:Amylases; D010447:Peptide Hydrolases; D014357:Trypsin