Studies on the mechanisms of chemical leukaemogenesis.
Following a single injection of MNU into "intact" mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the "target cells" in MNU leukaemogenesis.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D005260:Female; D007165:Immunosuppression Therapy; D007275:Injections, Intravenous; D007942:Leukemia, Experimental / Q000139:chemically induced* / Q000276:immunology; D051379:Mice; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D011830:Radiation Effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D013934:Thymectomy; D013997:Time Factors
D000951:Antigens, Neoplasm; D009607:Nitrosourea Compounds