Ineffectiveness of an oral killed typhoid vaccine in a field trial.
A field trial was carried out with a vaccine containing 300x10(9) killed S. typhi (strain Ty58) per tablet. A total of 12 564 children aged 1-15 years were given 3 tablets of the vaccine or a placebo at the rate of one tablet on each of 3 consecutive days. The results indicated that the vaccine, in its present form and at this dosage, gives no protection.
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005069:Evaluation Studies as Topic; D006801:Humans; D007194:India; D007223:Infant; D014435:Typhoid Fever / Q000517:prevention & control*; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage / Q000592:standards*; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000592:standards*
D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated