title: Translational control induced by bacteriophage T7.
abstract: Phage T7 discontinues host gene expression by translational and transcriptional control mechanisms. Translational control is exerted by the T7 translational-repressor. This protein inhibits the synthesis of beta-galactosidase (EC 3.2.1.23) in vivo and in vitro and the synthesis of the T3 enzyme S-adenosylmethioninehydrolase (EC 3.3.1.-). The translational-repressor does not interfere with T7-specific enzyme synthesis. The T7 translational-repressor purifies with the initiation factors. The repressor interacts with the initiation of translation of host enzymes. The translational-repressor gene is close to the promotor for RNA polymerase of Escherichia coli.
mesh_terms: D002874:Chromosome Mapping; D003090:Coliphages / Q000201:enzymology*; D004267:DNA Viruses / Q000201:enzymology; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004794:Enzyme Repression; D004926:Escherichia coli / Q000201:enzymology*; D005696:Galactosidases / Q000096:biosynthesis*; D005796:Genes; D005809:Genes, Regulator; D006867:Hydrolases / Q000096:biosynthesis*; D010442:Peptide Chain Initiation, Translational / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D012436:S-Adenosylmethionine; D014158:Transcription, Genetic; D014764:Viral Proteins / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D014764:Viral Proteins; D012436:S-Adenosylmethionine; D012321:DNA-Directed RNA Polymerases; D006867:Hydrolases; D005696:Galactosidases