Embryonic antigen expression on 2-acetylaminofluorene induced and spontaneously arising rat tumours.
2-Acetylaminofluorene induced mammary and ear duct carcinomata and spontaneously arising mammary carcinomata and sarcomata were shown to express embryonic antigens at the cell surface by their reaction with serum from multiparous female rats. These observations with essentially non-immunogenic tumours are comparable with early findings showing that embryonic antigens are also expressed on aminoazo dye induced rat hepatomata, and sarcomata induced with 3-methylcholanthrene. Re-expression of embryonal components, therefore, may be a concomitant of neoplastic transformation.
D000081:Acetamides; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D004428:Ear Neoplasms / Q000139:chemically induced / Q000276:immunology; D005260:Female; D005449:Fluorenes; D005455:Fluorescent Antibody Technique; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology
D000081:Acetamides; D002272:Carcinoembryonic Antigen; D005449:Fluorenes