title: Experimental genital infection of male guinea pigs with the agent of guinea pig inclusion conjunctivitis and transmission to females.
abstract: Male guinea pigs were inoculated intraurethrally with the agent of guinea pig inclusion conjunctivitis (Gp-ic). Cytoplasmic inclusions were found in superficial epithelial cells of the urethra in smears and stained sections. Gp-ic antigen(s) was detected by immunofluorescent staining of sections. There was no marked urethral exudate, but many animals developed bullous lesions on the glans and the body of the penis and a severe inflammatory lesion of the hind leg. All males demonstrated an antibody response and most of them showed a positive skin test reaction. Venereal transmission to females of Gp-ic infection was shown to occur as determined by detection of inclusions in vaginal smears, antibody response, and positive skin tests.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002689:Chlamydia / Q000302:isolation & purification*; D003235:Conjunctivitis, Inclusion / Q000382:microbiology*; D004195:Disease Models, Animal; D005260:Female; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D012749:Sexually Transmitted Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D012882:Skin Tests; D014521:Urethra / Q000276:immunology / Q000382:microbiology; D014621:Vagina / Q000382:microbiology; D014626:Vaginal Smears
chemical_list: D000907:Antibodies, Bacterial