title: Effect of isoprinosine against challenge with A(H3N2)-Hong Kong influenza virus in volunteers.
abstract: Volunteers were challenged with A(H(3)N(2))/Hong Kong/8/68 influenza virus while being given prophylaxis with either isoprinosine or placebo in a double-blind experiment. Isoprinosine, which had demonstrable antiviral activity in animal models, did not appear to protect humans from clinical influenza. The only beneficial effect of the drug observed was a slight, but significant, reduction in virus shedding.
mesh_terms: D000083:Acetanilides / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004123:Dimethylamines / Q000627:therapeutic use; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D007288:Inosine / Q000627:therapeutic use*
chemical_list: D000083:Acetanilides; D000998:Antiviral Agents; D004123:Dimethylamines; D007288:Inosine