title: Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 6: Clinical pharmacology. Placebo-controlled comparison of the constipating activity and safety of loperamide, diphenoxylate and codeine in normal volunteers.
mesh_terms: D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage / Q000494:pharmacology; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology*; D002722:Chlorobenzenes / Q000008:administration & dosage / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003061:Codeine / Q000494:pharmacology*; D003248:Constipation / Q000139:chemically induced; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D010919:Placebos; D012025:Reflex, Pupillary / Q000187:drug effects
chemical_list: D000577:Amides; D000930:Antidiarrheals; D002722:Chlorobenzenes; D005765:Gastrointestinal Agents; D007540:Isonipecotic Acids; D009570:Nitriles; D010880:Piperidines; D010919:Placebos; D009270:Naloxone; D003061:Codeine