Brain capillary blockage produced by a virulent strain of rodent malaria.
A sudden enhancement in virulence of a mild Plasmodium berghei yoelii 17 x strain resulted in fulminating and fatal infections in CF1 and A/J mice. The virulent strain has maintained its characteristics after ten cyclical transmissions through Anopheles stephensi. The visible expression of virulence of the mutated strain is its ability to cross the blood-brain barrier and cause intravascular sequestration of injected erythrocytes and blockage of brain capillaries. We, therfore, believe that the virulent line of Plasmodium berghei yoelii 17 x could serve as a useful laboratory model for the study of "cerebral malaria."
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D002196:Capillaries / Q000473:pathology; D002532:Intracranial Aneurysm / Q000473:pathology; D008288:Malaria / Q000097:blood / Q000473:pathology*; D051379:Mice; D008805:Mice, Inbred A; D008815:Mice, Inbred Strains; D009154:Mutation; D010962:Plasmodium berghei; D014774:Virulence