Gonadotrophin-releasing hormone therapy in hypogonadal males with hypothalamic or pituitary dysfunction.
Subcutaneous self-administration of synthetic gonadotrophin-releasing hormone 500 mug eight-hourly for up to one year by 12 male patients (five prepubertal) with clinical hypogonadism due to hypothalamic or pituitary disease resulted in the synthesis and continued release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There was a rise in circulating androgen levels in all patients. Improvements in pubertal ratings were seen in some prepubertal patients. Potency returned in the adults and spermatogenesis was induced and maintained in the four patients who had received treatment for more than four months, total counts reaching between 7.8 and 432 x 10(6) spermatozoa. A fall in the FSH response to the releasing hormone occurred during spermatogenesis though LH was little affected. During the initial weeks of therapy FSH secretion usually occurred before that of LH though LH secretion was greater as treatment continued. FSH secretion also persisted for longer when treatment was stopped.
D000172:Acromegaly / Q000150:complications; D000293:Adolescent; D000328:Adult; D001927:Brain Diseases / Q000150:complications; D001932:Brain Neoplasms / Q000150:complications; D003397:Craniopharyngioma / Q000150:complications; D013196:Dihydrotestosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D013006:Growth Hormone / Q000494:pharmacology; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy* / Q000209:etiology; D007031:Hypothalamus; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010900:Pituitary Diseases / Q000150:complications; D011485:Protein Binding; D011627:Puberty / Q000187:drug effects; D012712:Serum Globulins; D013091:Spermatogenesis; D013739:Testosterone / Q000097:blood
D012712:Serum Globulins; D013196:Dihydrotestosterone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone