Evidence that fusidic acid inhibits the binding of aminoacyl-tRNA to the donor as well as the acceptor site of the ribosomes.
D001665:Binding Sites; D002250:Carbon Radioisotopes; D002850:Chromatography, Gel; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005672:Fusidic Acid / Q000494:pharmacology*; D006160:Guanosine Triphosphate; D010452:Peptide Biosynthesis; D010441:Peptide Chain Elongation, Translational / Q000187:drug effects; D010445:Peptide Elongation Factors; D010649:Phenylalanine / Q000378:metabolism; D011691:Puromycin / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D012270:Ribosomes / Q000187:drug effects / Q000378:metabolism*
D002250:Carbon Radioisotopes; D010445:Peptide Elongation Factors; D012335:RNA, Ribosomal; D010649:Phenylalanine; D011691:Puromycin; D005672:Fusidic Acid; D006160:Guanosine Triphosphate; D012343:RNA, Transfer