An unusual intranuclear structure (? viral nucleocapsid) in the brain in subacute sclerosing panencephalitis.
A brain biopsy was examined from a 7 year old boy with subacute sclerosing panencephalitis. Intranuclear deposits of measles antigens were demonstrated in parenchymal cells by immunofluorescence. Electron microscopy showed viral nucleocapsids in nucleoliform inclusions and unusual rod-like intranuclear structures which resemble structures previously described only in tissue cultures infected with measles virus.
D000956:Antigens, Viral / Q000302:isolation & purification*; D001921:Brain / Q000382:microbiology*; D002467:Cell Nucleus; D002648:Child; D046508:Culture Techniques; D005455:Fluorescent Antibody Technique; D006801:Humans; D007181:Inclusion Bodies, Viral; D008297:Male; D008459:Measles virus / Q000302:isolation & purification*; D008854:Microscopy, Electron; D009474:Neurons / Q000382:microbiology; D013344:Subacute Sclerosing Panencephalitis / Q000382:microbiology*
D000956:Antigens, Viral