Comparison of ibuprofen and acetylsalicylic acid in the treatment of rheumatoid arthritis.
A double-blind crossover study of ibuprofen and acetylsalicylic acid was carried out in 27 patients with rheumatoid arthritis. Patients were evaluated by joint counts, grip-strength determination, erythrocyte sedimentation rate, and number of acetaminophen tablets required in addition to the test drug, as well as by various biochemical measurements. In the doses used ibuprofen and acetylsalicylic acid appeared comparable in anti-inflammatory effect, but statistically fewer side effects were observed during administration of ibuprofen.
D000082:Acetaminophen / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D001799:Blood Sedimentation; D002986:Clinical Trials as Topic; D006801:Humans; D008365:Manometry; D010666:Phenylpropionates / Q000627:therapeutic use*; D014527:Uric Acid / Q000032:analysis
D000893:Anti-Inflammatory Agents; D010666:Phenylpropionates; D014527:Uric Acid; D000082:Acetaminophen; D001241:Aspirin