Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast.
A yeast strain lacking the phenylalanine-sensitive DAHP synthetase exhibits a tyrosine-inhibited phenotype. Reversions from this phenotype were selected. They were the result of mutations affecting the tyrosine-sensitive DAHP synthetase which became insensitive to feedback inhibition, as shown by genetic and enzymatic studies. The feedback-insensitive mutations were located at five different sites scattered on the map of the aro4 gene.
D000446:Aldehyde-Lyases / Q000096:biosynthesis*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005246:Feedback; D005796:Genes; D006539:Heptoses; D008540:Meiosis; D009154:Mutation; D010641:Phenotype; D010649:Phenylalanine / Q000494:pharmacology; D010728:Phosphoenolpyruvate; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013780:Tetroses; D014443:Tyrosine / Q000494:pharmacology*
D006539:Heptoses; D013780:Tetroses; D014443:Tyrosine; D010649:Phenylalanine; D010728:Phosphoenolpyruvate; D000446:Aldehyde-Lyases