Some physiological and biochemical effects of a Coxiella burneti lipopolysaccharide preparation on guinea pigs.
A lipopolysaccharide obtained in a dialyzed phenol extract from the rickettsia Coxiella burneti produced the following effects in guinea pigs after intraperitoneal injection: hyperthermia, loss of body weight, increased liver weight and concomitant lipid infiltration, elevated levels of hepatic and plasma cortisol, increased incorporation of [(3)H]orotic acid into hepatic 28S and 18S ribosomal ribonucleic acid, increased incorporation of (14)C-labeled amino acids into liver and plasma protein, and leukocytosis. Most of these events also occur during infection of guinea pigs with C. burneti, and a causal relationship between the rickettsial lipopolysaccharide and the biochemical changes that occur during Q fever is suggested.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001431:Bacteriological Techniques; D001786:Blood Glucose / Q000032:analysis; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002250:Carbon Radioisotopes; D003381:Coxiella / Q000276:immunology*; D004247:DNA / Q000032:analysis; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood; D007958:Leukocyte Count; D008055:Lipids / Q000302:isolation & purification; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000032:analysis; D008297:Male; D009963:Orotic Acid / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011778:Q Fever / Q000276:immunology; D012313:RNA / Q000302:isolation & purification / Q000378:metabolism; D014020:Tissue Extracts; D014316:Tritium
D000596:Amino Acids; D001786:Blood Glucose; D002250:Carbon Radioisotopes; D008055:Lipids; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D014020:Tissue Extracts; D014316:Tritium; D009963:Orotic Acid; D012313:RNA; D004247:DNA; D006854:Hydrocortisone