Prazosin: preliminary report and comparative studies with other antihypertensive agents.
In a group of 14 hypertensive patients a 10-week course of treatment with prazosin 3-7.5 mg/day produced a significant reduction in mean blood pressure without serious side effects. The fall in diastolic pressure exceeded the response to a placebo by 10 mm Hg or more in 9 patients. The average decrease in diastolic pressure was similar to that produced by methyldopa 750 mg/day or propranolol 120-160 mg/day but the fall in systolic pressure was comparatively smaller, consistent with reported experimental work showing that the drug causes vasodilatation. The hypotensive effect of prazosin 1.5-3 mg/day combined with propranolol was significantly greater than that of propranolol alone and resulted in good control of blood pressure.
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004032:Diet; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use; D008750:Methyldopa / Q000627:therapeutic use; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D012964:Sodium
D000959:Antihypertensive Agents; D008738:Methyl Ethers; D010879:Piperazines; D011799:Quinazolines; D008750:Methyldopa; D012964:Sodium; D011433:Propranolol; D012083:Renin