Cellular requirements for the primary in vitro antibody response to DNP-ficoll.
The cellular requirements for the primary in vitro IgM and IgG response to dinitrophenyl-substituted Ficoll were examined. Neither thymus-derived lymphocytes nor macrophage-rich splenic adherent cells were required for anti-DNP antibody synthesis. DNP-Ficoll is therefore tentatively classified as a "thymic-independent" antigen.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology*; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D004140:Dinitrophenols; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D011134:Polysaccharides; D011409:Propylene Glycols; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013395:Sucrose; D013601:T-Lymphocytes / Q000276:immunology
D000906:Antibodies; D000941:Antigens; D004140:Dinitrophenols; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011134:Polysaccharides; D011409:Propylene Glycols; D013395:Sucrose