Double blind study with a new nitroimidazole derivative, Ro 7-0207, versus metronidazole in symptomatic intestinal amebiasis.
Of 115 patients with symptomatic intestinal amebiasis, 56 were treated with Ro 7-0207 and 59 with metronidazole in a double blind study. Results of treatment were similar in the two groups and side effects were of low intensity except in one patient who received Ro 7-0207 and developed numbness of hands and tongue, difficulty in speaking, and headache. These symptoms disappeared after termination of treatment.
D000433:1-Propanol / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000563:Amebicides / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004404:Dysentery, Amebic / Q000188:drug therapy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000009:adverse effects / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000009:adverse effects / Q000627:therapeutic use*
D000563:Amebicides; D009593:Nitroimidazoles; D008795:Metronidazole; D000433:1-Propanol