title: Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.
abstract: Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.
mesh_terms: D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000201:enzymology* / Q000378:metabolism; D005111:Extrachromosomal Inheritance; D007612:Kanamycin / Q000378:metabolism*; D009355:Neomycin / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism*
chemical_list: D007612:Kanamycin; D010770:Phosphotransferases; D009355:Neomycin