title: A new dihydrofolate reductase with low trimethoprim sensitivity induced by an R factor mediating high resistance to trimethoprim.
mesh_terms: D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000378:metabolism; D007700:Kinetics; D013696:Temperature; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014295:Trimethoprim / Q000378:metabolism*
chemical_list: D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase