Malignant melanoma: specific immunity induced by bacillus Calmette-Guérin in BALB-c mice.
Previous treatment of BALB/c mice with bacillus Calmette-Guérin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000912:Antibodies, Neoplasm / Q000032:analysis; D000961:Antilymphocyte Serum; D001500:BCG Vaccine; D002277:Carcinoma / Q000517:prevention & control; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D008214:Lymphocytes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D008545:Melanoma / Q000276:immunology / Q000517:prevention & control*; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000517:prevention & control; D014184:Transplantation, Homologous
D000907:Antibodies, Bacterial; D000912:Antibodies, Neoplasm; D000961:Antilymphocyte Serum; D001500:BCG Vaccine; D008748:Methylcholanthrene