Turbidimetric bioassay for carbenicillin.
A quantitative turbidimetric bioassay has been developed for carbenicillin with the use of a strain of Escherichia coli. The assay is relatively specific for carbenicillin and is not affected by 10% (wt/wt) benzylpenicillin. It has been demonstrated to be more precise than the plate diffusion assay. Since it is readily automated, it is also faster and less expensive. The influence of pH, time, and extent of growth on the assay has been evaluated.
D001681:Biological Assay; D002228:Carbenicillin / Q000032:analysis* / Q000494:pharmacology; D003720:Densitometry; D004926:Escherichia coli / Q000187:drug effects; D008722:Methods
D002228:Carbenicillin