Comparative immunogenicities of Chikungunya vaccines propagated in monkey kidney monolayers and chick embryo suspension cultures.
A comparative study was made of Formalin-inactivated Chikungunya vaccines prepared from the virus propagated in African green monkey kidney monolayers and concentrated chick embryo suspension cultures. The vaccine prepared in the chick embryo suspension cultures was significantly more protective to mice against a live homologous virus challenge and stimulated the production of 4 to 5 times more circulating antibodies than the vaccine prepared with virus grown in African green monkey kidney monolayer cultures.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D001102:Arbovirus Infections / Q000517:prevention & control; D002460:Cell Line / Q000382:microbiology; D002642:Chick Embryo; D002646:Chikungunya virus / Q000187:drug effects / Q000254:growth & development / Q000276:immunology*; D003168:Complement Fixation Tests; D046508:Culture Techniques; D005069:Evaluation Studies as Topic; D005557:Formaldehyde / Q000494:pharmacology; D000882:Haplorhini; D006385:Hemagglutination Inhibition Tests; D007274:Injections, Intraperitoneal; D007668:Kidney; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009500:Neutralization Tests; D014611:Vaccination; D014765:Viral Vaccines; D014776:Virus Cultivation
D000906:Antibodies; D014765:Viral Vaccines; D005557:Formaldehyde