Antidepressants and liver disease.
Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed.
D000639:Amitriptyline / Q000627:therapeutic use; D000641:Ammonia / Q000097:blood; D000643:Ammonium Chloride / Q000378:metabolism; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004569:Electroencephalography; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000378:metabolism; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy; D012890:Sleep; D014191:Tranylcypromine / Q000009:adverse effects* / Q000627:therapeutic use
D000643:Ammonium Chloride; D000639:Amitriptyline; D014191:Tranylcypromine; D000641:Ammonia