Immunogenicity of egg-grown influenza vaccine: inhibition by immunization of recipients with host antigen.
Rabbit antibody directed against normal allantoic fluid reduced the protective power of influenza vaccine prepared from egg-grown PR8 virus. A similar vaccine prepared from mouse lung virus was not inhibited. Preimmunization of mice with normal allantoic fluid or with egg-grown influenza B/Lee vaccine (crude or purified) inhibited the protective power of PR8 egg vaccine but did not affect a similar lung vaccine.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004531:Eggs; D005321:Extraembryonic Membranes / Q000276:immunology; D005163:Factor Analysis, Statistical; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D007106:Immune Sera; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007252:Influenza Vaccines; D008168:Lung / Q000276:immunology; D051379:Mice; D009975:Orthomyxoviridae / Q000276:immunology; D011817:Rabbits / Q000276:immunology
D000914:Antibodies, Viral; D007106:Immune Sera; D007252:Influenza Vaccines