title: Lumbosacral agenesis: management and embryological implications.
abstract: Rectal biopsy in a case of lumbosacral agenesis showed the presence of autonomic nerve elements normally supplied by spinal levels distal to the agenesis. Certain implications are suggested regarding the embryogenesis of this condition from data about the development of neural, bony, and muscular elements. Recommendations regarding management are given.
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000002:abnormalities; D001706:Biopsy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007866:Leg / Q000294:innervation; D008159:Lumbar Vertebrae / Q000002:abnormalities*; D009454:Neurofibrils; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D012007:Rectum / Q000473:pathology; D016135:Spinal Dysraphism / Q000196:embryology / Q000628:therapy*