title: Developmental analysis of the wing disc in the mutant engrailed of Drosophila melanogaster.
abstract: The engrailed (en) mutation leads to the transformation of the posterior structures of the dorsal mesothoracic disc into those characteristic of the anterior region of the same disc. Similar posterior-anterior duplications have been detected in dorsal as well as ventral structures of all the thoracic segments. -Genetic combinations of en with other pattern mutants have shown their synergistic effect on the posterior wing pattern.-A clonal analysis of the en wing disc shows that en affects its development in a characteristic way. The genetic change, by induced mitotic recombination, of en(+) into en cells is followed by the corresponding transformation, except when it takes place some cell divisions prior to differentiation.-The en posterior wing disc cells show positive affinities with normal anterior wing disc cells in aggregates.-The mode of action of the en(+) locus controlling wing disc development is discussed.
mesh_terms: D000367:Age Factors; D000818:Animals; D002999:Clone Cells; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000254:growth & development* / Q000528:radiation effects; D005838:Genotype; D007814:Larva / Q000254:growth & development / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects; D009030:Mosaicism; D009154:Mutation; D010641:Phenotype; D011679:Pupa / Q000254:growth & development; D011830:Radiation Effects; D011995:Recombination, Genetic / Q000528:radiation effects; D014921:Wings, Animal / Q000254:growth & development*