Photodynamic treatment of herpes keratitis.
Photodynamic inactivation of virus was tested as a potential therapeutic tool for herpesvirus-induced keratitis, which is a leading cause of blindness and disability. Experimental keratitis produced in rabbits by infection with herpesvirus isolated from a human periorbital lesion was treated with proflavine and light. The herpetic keratitis could be rapidly resolved by the dye-light treatment, whereas improvement was not seen in untreated rabbits, nor in those treated with light alone or dye alone.
D000166:Acridines / Q000627:therapeutic use*; D000588:Amines / Q000627:therapeutic use; D000818:Animals; D066298:In Vitro Techniques; D007635:Keratitis, Dendritic / Q000188:drug therapy / Q000628:therapy*; D008027:Light; D011817:Rabbits; D013997:Time Factors
D000166:Acridines; D000588:Amines