title: Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase.
abstract: The diurnal cycle of hepatic HMG CoA reductase activity was studied under conditions of controlled feeding where the percentage of dietary lipid, alone or in combination with 2% cholestyramine, was varied. Cholestyramine caused an increase in HMG CoA reductase activity that began soon after feeding started and peaked 6 hr later. In contrast, a diet containing 20% corn oil was a much weaker inducer of the enzyme but caused a prolonged elevation that began late in the fasting part of the cycle. These patterns suggest two different mechanisms of action.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002247:Carbon Isotopes; D002792:Cholestyramine Resin / Q000494:pharmacology*; D002940:Circadian Rhythm; D004041:Dietary Fats / Q000494:pharmacology*; D005247:Feeding Behavior; D005977:Glutarates; D008099:Liver / Q000201:enzymology*; D008297:Male; D008798:Mevalonic Acid; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D013268:Stimulation, Chemical
chemical_list: D002247:Carbon Isotopes; D004041:Dietary Fats; D005977:Glutarates; D002792:Cholestyramine Resin; D000429:Alcohol Oxidoreductases; D008798:Mevalonic Acid