Comparative effect of oxygen and nitrate on protoporphyrin and heme synthesis from delta-amino levulinic acid in bacterial cultures.
Pseudomonas aeruginosa and P. denitrificans accumulate more protoheme and considerably more protoporphyrin during anaerobic growth under denitrifying conditions than during aerobic growth. In Escherichia coli, the small accumulation of protoporphyrin and protoheme which occurs during anaerobic growth is slightly stimulated by nitrate and markedly stimulated by oxygen.
D000332:Aerobiosis; D000693:Anaerobiosis; D003470:Culture Media; D004926:Escherichia coli / Q000032:analysis / Q000378:metabolism*; D006418:Heme / Q000032:analysis / Q000096:biosynthesis*; D007982:Levulinic Acids / Q000378:metabolism*; D009566:Nitrates / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology*; D011166:Porphyrins / Q000032:analysis / Q000096:biosynthesis*; D011549:Pseudomonas / Q000032:analysis / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000032:analysis / Q000378:metabolism; D013237:Stereoisomerism; D013268:Stimulation, Chemical
D003470:Culture Media; D007982:Levulinic Acids; D009566:Nitrates; D011166:Porphyrins; D006418:Heme; D010100:Oxygen