title: [AMP-aminohydrolase of the brain and other organs and the regulation of its activity].
abstract: Present concepts of the hydrolytic deamination of adenylic acid through AMP-aminohydrolase of brain and other tissues are discussed. The content of AMP-aminohydrolase of tissues, its intracellular disposition, physico-chemical properties, physiological role and the regulation of its activity are considered. AMP-aminohydrolase of brain is compared with that of other tissues (muscle, liver, kidney, erythrocytes, etc.), and characteristic features of the regulation of its activity in brain tissue is included. The participation of nucleotides, phosphoorganic compounds, hexokinase and some cations in the regulation of AMP-aminohydrolase activity of brain and other tissues are discussed on the basis of the experiments carried out and the data available.
mesh_terms: D000659:AMP Deaminase / Q000302:isolation & purification / Q000378:metabolism* / Q000502:physiology; D000494:Allosteric Regulation; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002384:Catalysis; D004912:Erythrocytes / Q000201:enzymology; D006019:Glycolysis; D006168:Guinea Pigs; D006801:Humans; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D009119:Muscle Contraction; D009132:Muscles / Q000201:enzymology; D009709:Nucleotide Deaminases / Q000378:metabolism*; D011817:Rabbits; D013057:Spectrum Analysis; D013379:Substrate Specificity
chemical_list: D009709:Nucleotide Deaminases; D000659:AMP Deaminase
vernacular_title: AMF-aminogidrolaza mozga i drugikh organov i reguliatsiia ee aktivnosti.