Cross-protective antigens of Neisseria meningitidis obtained from Slaterus group Y.
An extraction of the cells of Neisseria meningitidis serogroup Y with an aqueous solution of calcium choride (0.9 m) has been shown to solubilize a number of antigens. By immunodiffusion, this mixture of antigens has been shown to react with its group-specific antiserum and also to cross-react with a number of other group-specific antisera. The cross-reacting antigen appears to be an antigen common to a number of other serogroups of meningococci, and there is some evidence that it is protein in nature. It has been demonstrated further that the calcium chloride extract contains a strong cross-protective antigen, as shown by its ability to provide good, active immunity in mice to both the homologous and heterologous serogroups of meningococci.
D000818:Animals; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial / Q000032:analysis*; D002122:Calcium Chloride; D002852:Chromatography, Ion Exchange; D002918:Chymotrypsin; D003429:Cross Reactions; D005612:Freeze Drying; D006868:Hydrolysis; D007111:Immunity, Cellular; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009345:Neisseria meningitidis / Q000276:immunology*; D013997:Time Factors; D014357:Trypsin
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D002918:Chymotrypsin; D014357:Trypsin; D002122:Calcium Chloride