[Uptake of methyl-12-benzo (a) and methyl-7-benzo (c) acridines by target organs of the female rat studied by fluorescence microscopy (author's transl)].
The diffusion and uptake of two benzacridines with very similar chemical structures, but with different carcinogenic powers were investigated at the level of various organs and at the cellular level in the female rat. The chronology of the processes and lesions observed was different according to the respective carcinogenic power of the two benzacridines. On account of the small doses used, only necrotic lesions were observed, mainly in the liver and adrenal glands, but no tumorous lesions were observed. Uptake of fluorescent substance at the level of the nuclei of certain cells (submaxillaris, liver, pancreas, adrenal glands) was noticed as in previous experiments; this transient process appeared about the 100th day and lasted fairly long according to the form of benzacridine and the organ.
D000166:Acridines / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects; D005260:Female; D008168:Lung / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008856:Microscopy, Fluorescence; D010053:Ovary / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013997:Time Factors
D000166:Acridines
Etude en microscopie de fluorescence de la fixation des méthyl-12-benzo (a) et méthyl-7-benzo (c) acridines sur les organes cibles du rat femelle