Effect of anti-cord factor antibody on experimental tuberculosis in mice.
Either active immunization with trehalose-6, 6'-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis. This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cord factor during the course of living virulent infection with tubercle bacilli. The protective effect of active immunization with cord factor-methylated bovine serum albumin complex and of anti-cord factor serum was found to be specific for the tuberculous infection among a number of experimental infections in mice with a variety of cytopathogenic microorganisms tested.
D000818:Animals; D000906:Antibodies; D002003:Brucella abortus / Q000276:immunology; D007106:Immune Sera; D007112:Immunity, Maternally-Acquired; D007114:Immunization; D007116:Immunization, Passive; D008089:Listeria monocytogenes / Q000276:immunology; D008168:Lung / Q000382:microbiology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000302:isolation & purification; D009171:Mycolic Acids; D012477:Salmonella enteritidis / Q000276:immunology; D012486:Salmonella typhimurium / Q000276:immunology; D012710:Serum Albumin, Bovine; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000276:immunology*
D000906:Antibodies; D007106:Immune Sera; D009171:Mycolic Acids; D012710:Serum Albumin, Bovine