[Corticosteroids in high doses and sympathetic adrenergic response].
The sympathetic adrenergic response and some of its repercusions are anlayzed in 150 patients who underwent open-heart surgery. 75 received a high dose of steroids before bypass and rest served as control. The sympathetic adrenergic response measured  by the level of steroids in blood, plasme and urine was similar in both groups. None of the metabolic actions attributed to corticosteroids (Gluconeogenesis, protein catabolism, mineralcorticoid effect), were observed. Postoperative hemorrage was not great in the group of patients who received steroids, the excellent circulation in this group of patients, showed by the clinical exploration and renal dynamics was noted.
D000302:Adrenal Cortex / Q000187:drug effects*; D000311:Adrenal Glands / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005112:Extracorporeal Circulation; D006331:Heart Diseases / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D007267:Injections; D008111:Liver Function Tests; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects*
D008775:Methylprednisolone
Corticoesteroides a dósis altas y respuesta sinpaticoadrenal