Resistance of bacteriophage PBS2 infection to 6-(p-hydroxyphenylazo)-uracil, an inhibitor of Bacillus subtilis deoxyribonucleic acid synthesis.
6-(p-Hydroxyphenylazo)-uracil (HPUra), an inhibitor of semiconservative deoxyribonucleic acid (DNA) synthesis in Bacillus subtilis, does not prevent (but slightly reduces the rate of) replication of the uracil-containing DNA phage PBS2. Our observations are consistent with the hypothesis that all B. subtilis phages which are resistant to HPUra are able to induce a new DNA polymerase activity.
D001391:Azo Compounds; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism*; D001435:Bacteriophages / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004267:DNA Viruses / Q000187:drug effects*; D004269:DNA, Bacterial / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D004279:DNA, Viral / Q000096:biosynthesis; D010430:Pentosyltransferases / Q000378:metabolism; D010636:Phenols; D014498:Uracil / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D001391:Azo Compounds; D004269:DNA, Bacterial; D004279:DNA, Viral; D010636:Phenols; D014498:Uracil; D010430:Pentosyltransferases; D004254:DNA Nucleotidyltransferases