Comparison of fluorescent antibody induced by rubella virus in vaccinee and convalescent individuals.
Specific rubella antibody detectable by indirect immunofluorescence developed in response to immunization with attenuated rubella vaccine, HPV-77, DK-12. Fluorescent antibody (FA) was found when vaccinee sera were reacted with antigens synthesized in three different acutely infected continuous cell lines: BHK-21, LLCMK-2, and RK-13. FA titers were high, and they correlated with antibody titers obtained by hemagglutination-inhibition tests. Levels of FA in vaccinated individuals were slightly lower than those found in persons recovered from natural rubella infections. Rubella FA persists a long time in convalescent individuals and appears to be maintained for at least 19 months in vaccinees.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D000956:Antigens, Viral / Q000302:isolation & purification; D002460:Cell Line; D002645:Chickens; D003289:Convalescence; D006224:Cricetinae; D004912:Erythrocytes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D000882:Haplorhini; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007114:Immunization; D007668:Kidney; D008856:Microscopy, Fluorescence; D012409:Rubella / Q000276:immunology*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000254:growth & development / Q000276:immunology*; D014765:Viral Vaccines; D014776:Virus Cultivation
D000906:Antibodies; D000956:Antigens, Viral; D012411:Rubella Vaccine; D014765:Viral Vaccines