title: [First observations on the topical use of Primin, Plumbagin and Maytenin in patients with skin cancer].
abstract: Eleven cases of patients bearing basic cellular carcinoma, and one case of patient bearing Kaposi's sarcomatosis, all treated with antibiotics isolated by Goncalves de Lima and Co-workers at the Instituto de Antibióticos, are presented by the authors. Primin, an antibiotic extracted from a vegetal named Miconia sp. (Herb. I.A.-1903) with a 2-metoxi-6-n-pentil-p benzoquinone structure, presented a strong antineoplastic action in the cases treated. Plumbagin isolated from Plumbago scandens in local use, was responsible for a complete healing of the injuries treated. Maytenin extracted from Maytenus sp. (Herb. I.A.-1750) showed less activity than the two previous mentioned, but with a low irritant action and late antineoplastic properties. The authors are going on these experiments. They believe that these antibodies, in local use, may advantageously substitute the surgery and the radiotherapy, meanly in those external ear tumidities and back of the nose, owing to a hurtful action in cartilage, provoked by radiotherapy.
mesh_terms: D000328:Adult; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005153:Facial Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009285:Naphthoquinones / Q000008:administration & dosage* / Q000627:therapeutic use; D009824:Ointments; D011809:Quinones / Q000008:administration & dosage* / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; D009824:Ointments; D011809:Quinones
vernacular_title: Primeiras observações do uso tópico da primina, plumbagina e maitenina em pacientes portadores de cáncer de pele