Requirement of thymus (T) lymphocytes for resistance to listeriosis.
Spleen cells of mice infected with Listeria monocytogenes were adoptively transferred to normal mice. Such lymphocytes conferred resistance to a lethal challenge with Listeria. Hyperimmunization of the donor reduces the number of cells necessary to transfer effective immunity. Such spleen cells if treated with anti-theta serum do not transfer resistance to Listeria. Hence, thymus (T) lymphocytes are involved in the resistance to infection with the facultative intracellular bacteria L. monocytogenes.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007106:Immune Sera; D007110:Immunity, Active; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008089:Listeria monocytogenes / Q000276:immunology; D008088:Listeriosis / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*
D007106:Immune Sera