title: Copper on intrauterine devices stimulates leukocyte exudation.
abstract: Metallic copper in the uterine or abdominal cavities of rats or monkeys stimulates an impressive local exudation of polymorphonuclear leukocytes. This cellular response to copper persists for at least 7 months, without significant local tissue damage or detectable systemic effects on the test animal. This finding provides a possible explanation for the capacity of copper to increase impressively the antifertility effect of polyethylene intrauterine contraceptive devices.
mesh_terms: D000818:Animals; D003300:Copper / Q000494:pharmacology*; D004847:Epithelial Cells; D005260:Female; D000882:Haplorhini; D007434:Intrauterine Devices; D007962:Leukocytes / Q000166:cytology*; D051381:Rats; D014599:Uterus / Q000166:cytology* / Q000187:drug effects
chemical_list: D003300:Copper