title: Antidepressants and liver disease.
abstract: Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed.
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use; D000641:Ammonia / Q000097:blood; D000643:Ammonium Chloride / Q000378:metabolism; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D004569:Electroencephalography; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000378:metabolism; D009422:Nervous System Diseases / Q000150:complications / Q000188:drug therapy; D012890:Sleep; D014191:Tranylcypromine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000643:Ammonium Chloride; D000639:Amitriptyline; D014191:Tranylcypromine; D000641:Ammonia