Evidence for active immunity to morphine in mice.
The serum from mice actively immunized with a morphine immunogen contained antibodies that could bind dihydromorphine. Morphine effects were diminished in these "immunized" mice, and the concentration of morphine in their plasma was altered.
D000698:Analgesia; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D004361:Drug Tolerance; D005620:Freund's Adjuvant; D007110:Immunity, Active; D007114:Immunization; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D014316:Tritium
D014316:Tritium; D009020:Morphine; D005620:Freund's Adjuvant