Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone.
Thyrotropin releasing hormone potentiates the behaviorial effects of dopa plus pargyline in mice. Because the potentiation occurs in hypophysectomized mice, as well as in normal mice, the phenomenon is independent of the release of thyroid stimulating hormone from the pituitary. Possible mechanisms and clinical implications are discussed.
D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007016:Hypophysectomy; D007274:Injections, Intraperitoneal; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000008:administration & dosage / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013973:Thyrotropin-Releasing Hormone; D004295:Dihydroxyphenylalanine; D010293:Pargyline