Physicochemical properties of Neisseria meningitidis group X polysaccharide antigen.
Neisseria meningitidis group X occurs in human carrier populations and is rarely implicated in serious disease. This organism possesses a capsular group antigen which is an acidic polysaccharide. It is composed of the amino sugars, glucosamine, glucosamine-6-phosphate, galactosamine, and the simple hexose, glucose. The group X capsular antigen has an S(20,w) (0) of 3.6, and the acidic nature of the polysaccharide is reflected in an isoelectric point of 3.65. The meningococcal A, B, C, and Y polysaccharide group antigens are also composed primarily of amino sugars. The chemical composition of the group X antigen most closely resembles the capsular antigen of N. meningitidis group Y, which is also predominately a carrier organism.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis*; D002353:Carrier State / Q000382:microbiology; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004589:Electrophoresis, Disc; D004731:Endotoxins / Q000032:analysis; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006595:Hexosamines / Q000032:analysis; D006601:Hexoses / Q000032:analysis; D006801:Humans; D007106:Immune Sera; D009345:Neisseria meningitidis / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D010429:Pentoses / Q000032:analysis; D011135:Polysaccharides, Bacterial / Q000032:analysis*; D011402:Pronase / Q000494:pharmacology; D011817:Rabbits / Q000276:immunology; D014357:Trypsin / Q000494:pharmacology
D000596:Amino Acids; D000942:Antigens, Bacterial; D004731:Endotoxins; D006595:Hexosamines; D006601:Hexoses; D007106:Immune Sera; D010429:Pentoses; D011135:Polysaccharides, Bacterial; D014357:Trypsin; D011402:Pronase