Functional residual capacity during anaesthesia. II. Spontaneous respiration.
Functional residual capacity has been measured by helium dilution in 26 spontaneously breathing patients before and immediately after anaesthesia, which was induced with thiopentone and maintained with halothane. The mean reduction was 390 ml (16.1% or pre-induction value) and the change was highly significant (P less than 0.001). The decrease in FRC correlated with age (r equals 0.41: P less than 0.005) and less (P less than 0.001). The decrease in FRC correlated with age (r equals 0.41; P less than 0.005) and less satisfactorily with the weight/height ratio (r equals 0.31; P less than 0.05) which itself correlated with age. Inspired oxygen concentration, expiratory reserve volume and the presence of phasic expiratory muscle activity bore no significant relationship to the decrease in FRC. There was no evidence of any progressive change in FRC between 6 and 20 min after the induction of anaesthesia.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000769:Anesthesia, Inhalation; D001827:Body Height; D001835:Body Weight; D004576:Electromyography; D006221:Halothane; D006371:Helium; D006801:Humans; D007201:Indicator Dilution Techniques; D007366:Intercostal Muscles / Q000502:physiology; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D012115:Residual Volume; D012119:Respiration; D013147:Spirometry; D013874:Thiopental; D013997:Time Factors
D006371:Helium; D013874:Thiopental; D010100:Oxygen; D006221:Halothane