Tremor and involuntary movements in monkeys: effect of L-dopa and of a dopamine receptor stimulating agent.
Either L-dopa, in combination with 1-alpha-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor in monkeys and concomitantly evokes involuntary movements. These results indicate that tremor and involuntary movements are associated with a common mechanism and that the activity of the dopamine receptors is involved in the regulation of these dysfunctions.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D004569:Electroencephalography; D006220:Haloperidol / Q000494:pharmacology; D000882:Haplorhini; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology / Q000627:therapeutic use; D006948:Hyperkinesis / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008750:Methyldopa / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008781:Methyltyrosines / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014202:Tremor / Q000188:drug therapy*
D001593:Benzyl Compounds; D004149:Dioxoles; D006834:Hydrazines; D008781:Methyltyrosines; D010848:Picolinic Acids; D010879:Piperazines; D011743:Pyrimidines; D008750:Methyldopa; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D006220:Haloperidol