Antibody and immunoglobulin response to antirabies vaccination in man.
Serum neutralization antibody and immunoglobulin responses in 30 individuals were studied in paired serum samples which had been obtained before and 2 to 3 weeks after the administration of a recall dose of rabies tissue culture vaccine. The immune reaction consisted of a predominantly immunoglobulin G (IgG) antibody response. Also, a significant increase in neutralizing antibody titers was observed, but without a consistently correlated change of the IgG levels in the individual serum samples. The radial immunodiffusion test appears to contain the elements necessary for the development of a routine test to determine rabies antibody in single serum samples.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects*; D000918:Antibody Specificity; D000941:Antigens / Q000032:analysis; D002417:Cattle / Q000276:immunology; D006224:Cricetinae / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007115:Immunization Schedule; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D009500:Neutralization Tests; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000494:pharmacology*; D014611:Vaccination
D000906:Antibodies; D000914:Antibodies, Viral; D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011819:Rabies Vaccines