Transplacental transmission of Venezuelan equine encephalomyelitis virus in mice.
Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 10(3) suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to mating to 9 days after conception, had no effect on conception rate, litter size, or survival of the newborn. Inoculation of the dam from the 10th to 13th days of gestation resulted in decreased litter size, an increase in stillbirths, and a decrease in birth-to-weaning survival. Inoculation of the dams later in gestation only decreased the birth-to-weaning survival. No evidence of morphologic abnormality was noted in any of the newborn.
D000818:Animals; D000831:Animals, Newborn; D004666:Encephalitis Virus, Venezuelan Equine / Q000472:pathogenicity; D004683:Encephalomyelitis, Equine / Q000401:mortality; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005865:Gestational Age; D007928:Lethal Dose 50; D008431:Maternal-Fetal Exchange; D051379:Mice; D010920:Placenta / Q000382:microbiology; D011247:Pregnancy; D013997:Time Factors