The effect of betahistine on gastric acid secretion and mucosal blood flow in conscious dogs.
In 3 conscious dogs, betahistine (2-(2'-methyl aminoethyl pyridine)) (80 or 160mug kg(-1) min(-1)) increased acid secretion from Heidenhain pouches to 8.8% and 17.6% respectively of the maximal response to histamine. Betahistine also increased mucosal blood flow (radioactive aniline clearance). The ratio of mucosal blood flow to secretion was greater for betahistine than for histamine but the difference between betahistine and histamine was significant in only one of the dogs.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000818:Animals; D004285:Dogs; D005021:Ethylamines / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply*; D006632:Histamine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*
D005021:Ethylamines; D011725:Pyridines; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); D010418:Pentagastrin