Immunosuppression of mice injected with heterologous anti-immunoglobulin heavy chain antisera.
Neonatal injection of mice with rabbit anti-micro antiserum has been shown to produce complete loss of direct and indirect plaque-forming responses to sheep erythrocytes as well as loss of serum IgM and severe depressions of all other serum immunoglobulins. Similar injection of anti-gamma1gamma2 or anti-gamma1 antibodies effects a loss of the indirect response but induces relatively minor alterations in serum Ig levels. Delaying initiation of anti-micro treatment until young adulthood results in a somewhat diminished effect on plaque-forming responses and serum Ig levels but triggers the release of high serum levels of an aberrant micro-bearing protein. Anti-micro suppression of genetically thymusless mice indicates that at least part of the target cells for suppression are bone marrow derived. A working hypothesis for the maturation of humoral antibody-producing cell lines as it relates to these data is discussed.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000921:Antibody-Producing Cells; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D006462:Hemolytic Plaque Technique; D005779:Immunodiffusion; D007125:Immunogenetics; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000037:antagonists & inhibitors*; D007165:Immunosuppression Therapy; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D010455:Peptides / Q000037:antagonists & inhibitors; D011817:Rabbits / Q000276:immunology; D011833:Radiation Injuries, Experimental / Q000276:immunology; D013950:Thymus Gland / Q000002:abnormalities / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007136:Immunoglobulins; D010455:Peptides