Inhibition of pig kidney diamine oxidase by substrate analogues.
1. The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced. 2. This reaction was inhibited by substrate analogues such as isothiouronium, guanidino, dimethylsulphonium and trimethylammonium compounds. 3. The inhibition by both mono- and bis-onium compounds has been studied and a comprehensive theory is developed to explain both the type and degree of inhibition produced.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000818:Animals; D001547:Benzaldehydes; D006146:Guanidines / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology*; D009861:Onium Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D013053:Spectrophotometry; D013552:Swine; D013890:Thiourea
D001547:Benzaldehydes; D006146:Guanidines; D009861:Onium Compounds; D000644:Quaternary Ammonium Compounds; D006631:Amine Oxidase (Copper-Containing); D013890:Thiourea