Functional evaluation of prolactin secretion: a guide to therapy.
Stimulation and inhibition tests are proposed for evaluating prolactin secretion. Thyrotropin-releasing hormone (TRH) stimulates the release of prolactin from the pituitary. Chlorpromazine acts presumably at the hypothalamic level to increase prolactin secretion. L-Dopa (D,L-alpha-hydrazino-alpha-methyl-beta-[3,4-di-hydroxyphenyl]) has the opposite effect; it inhibits prolactin secretion and may be effective in suppressing galactorrhea.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007775:Lactation Disorders / Q000188:drug therapy*; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D004295:Dihydroxyphenylalanine; D011388:Prolactin; D013972:Thyrotropin; D002746:Chlorpromazine