Isolation and characterization of an isolate (HN) of Marek's disease virus with low pathogenicity.
A cytopathic agent was isolated and characterized as an isolate of Marek's disease herpesvirus (MDHV) with low pathogenicity, and referred to as the HN isolate. This isolate of MDHV did not cause clinical Marek's disease (MD) or death in a highly susceptible line of chickens within 5 weeks after exposure. Gross lesions of limited extent were noted in a few of the inoculated birds. Microscopic nerve lesions in the inoculated and contact-infected birds were invariably minimal, closely resembling C-type MD lesions.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line; D002642:Chick Embryo; D002645:Chickens; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D004279:DNA, Viral / Q000032:analysis; D005347:Fibroblasts; D005455:Fluorescent Antibody Technique; D006564:Herpesviridae / Q000032:analysis / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D007065:Idoxuridine / Q000494:pharmacology; D005779:Immunodiffusion; D007668:Kidney; D008380:Marek Disease / Q000382:microbiology* / Q000473:pathology; D009420:Nervous System / Q000473:pathology; D009522:Newcastle disease virus / Q000254:growth & development; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D004279:DNA, Viral; D007065:Idoxuridine