title: Effect of oxidized spermine and other aldehydes on the infectivity of vaccinia virus.
abstract: The antiviral activity of oxidized spermine was compared with that of other aldehydes. Suspensions of vaccinia virus were incubated at 37 C with various concentrations of the aldehydes, and the infectivity of the viruses was determined by the plaque assay. Oxidized spermine at a concentration of 0.82 mM completely inactivated a suspension of vaccinia virus (1.4 x 10(8) plaque-forming units) after incubation at 37 C for 10 hr. Glutaraldehyde and formaldehyde were less active when compared on a molar basis, but acrolein resembled oxidized spermine in its antiviral activity. Because acrolein is produced from oxidized spermine at only 20 to 30% yield, it is unlikely that the biological activity of the latter is due to acrolein formed during the spontaneous degradation of oxidized spermine.
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D005557:Formaldehyde / Q000494:pharmacology; D000882:Haplorhini; D006462:Hemolytic Plaque Technique; D007668:Kidney; D013096:Spermine / Q000494:pharmacology*; D013696:Temperature; D013997:Time Factors; D014616:Vaccinia virus / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000447:Aldehydes; D000998:Antiviral Agents; D003470:Culture Media; D005557:Formaldehyde; D013096:Spermine