Repair of UV-induced pyrimidine dimers in Drosophila melanogaster cells in vitro.
Tissue culture cells of Drosophila melanogaster were given various doses of ultraviolet light. The results indicate that Drosophila cells do have a dark-repair excision mechanism which is not sensitive to caffeine. Pyrimidine dimers were destroyed by photoreactivating illumination in these cells and this destruction probably represents monomerization of the pyrimidine dimers.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002478:Cells, Cultured / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects; D004331:Drosophila melanogaster; D008027:Light; D009154:Mutation; D011743:Pyrimidines / Q000096:biosynthesis*; D011830:Radiation Effects; D014466:Ultraviolet Rays
D011743:Pyrimidines; D002110:Caffeine; D004247:DNA