Benign obstetric history in women with sickle-cell anaemia associated with  -thalassaemia.
Two Ghanaian women with sickle-cell anaemia and alpha-thalassaemia were found to have an unusually benign obstetric history. In addition to two factors present which are known to moderate the clinical course of sickle-cell anaemia, good socioeconomic status and a relatively high Hb F level, it is suggested that alpha-thalassaemia may act among other things by lowering the haemoglobin concentration in the red cells and thereby lowering their tendency to sickle in vivo.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D044383:Black People; D001853:Bone Marrow / Q000378:metabolism; D005260:Female; D005319:Fetal Hemoglobin; D005869:Ghana; D006455:Hemoglobins, Abnormal; D006801:Humans; D007501:Iron / Q000097:blood; D007930:Leucine / Q000378:metabolism; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D012923:Social Class; D013789:Thalassemia / Q000150:complications*; D014316:Tritium; D014481:United States; D001741:Black or African American
D006455:Hemoglobins, Abnormal; D014316:Tritium; D005319:Fetal Hemoglobin; D007501:Iron; D007930:Leucine