Folate antagonists. 3. 2,4-Diamino-6-(heterocyclic)quinazolines, a novel class of antimetabolites with potent antimalarial and antibacterial activity.
D000588:Amines / Q000138:chemical synthesis; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D000963:Antimetabolites / Q000138:chemical synthesis* / Q000627:therapeutic use; D014355:Chagas Disease / Q000188:drug therapy; D002642:Chick Embryo; D002645:Chickens; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000588:Amines; D000890:Anti-Infective Agents; D000962:Antimalarials; D000963:Antimetabolites; D005493:Folic Acid Antagonists; D006571:Heterocyclic Compounds; D011799:Quinazolines