title: [The effect of rastinon on the beta cells of the rat and guinea pig pancreas].
abstract: Investigations are carried out with light and electron microsckope on the islands of Langerhans in rats and guinea pigs following Rastinon treatment over variable time intervals. The beta cells were strongly activied: with expanded ergastoplasm (archiplasm), enlarged and elongated mitochondria, Golgi's complex of a multiple vesiculose type, abudance of coated vesicles, marginization of secreting B-granules along the cellular membranes and perforated sacs. In addition, mixed island-acinous cells and bright degranulated and agranulated cells, which represent beta cells in different phases of insulin secretion, were observed. The bright agranulated cells are assumed as demontrating a refrangible recovery phase of the beta cells.
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D051381:Rats; D014044:Tolbutamide / Q000494:pharmacology*
chemical_list: D014044:Tolbutamide
vernacular_title: Efekt na rastinona vurkhu B-kletkite na pankreasa na plukha i morskoto svinche