Serotype and sulphonamide sensitivity of meningococci isolated from 1966 to 1971.
From 1966 to 1971, 298 cultures of meningococci from clinical material (cerebrospinal fluid or blood) were examined. Eighty-nine cultures were from the Manchester area and the remainder from other parts of England or Northern Ireland. Five per cent of strains were group A, 57% group B, and 31% group C; 6% were untypable. Eighteen strains (6%) had an MIC of 6.4 mug/ml or more of sodium sulphadiazine and 10 of these (3.5%) an MIC of 50 to 100 mug/ml. The incidence of sulphonamide resistance was higher in group A strains than in group B or group C strains.
D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests; D009345:Neisseria meningitidis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D012703:Serotyping; D013411:Sulfadiazine / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*
D013449:Sulfonamides; D013411:Sulfadiazine