title: Inhibition of thymidylate synthetase by showdomycin and its 5'-phosphate.
mesh_terms: D004229:Dithiothreitol; D004352:Drug Resistance, Microbial; D006865:Hydrogenation; D007780:Lacticaseibacillus casei / Q000201:enzymology; D008301:Maleimides / Q000494:pharmacology; D008623:Mercaptoethanol / Q000494:pharmacology; D008727:Methotrexate / Q000494:pharmacology; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D012263:Ribonucleosides / Q000494:pharmacology*; D012265:Ribonucleotides / Q000494:pharmacology*; D013053:Spectrophotometry; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors / Q000302:isolation & purification; D013997:Time Factors; D014500:Uracil Nucleotides / Q000494:pharmacology
chemical_list: D008301:Maleimides; D012263:Ribonucleosides; D012265:Ribonucleotides; D013439:Sulfhydryl Reagents; D014500:Uracil Nucleotides; D008623:Mercaptoethanol; D008780:Methyltransferases; D013940:Thymidylate Synthase; D004229:Dithiothreitol; D008727:Methotrexate