title: Temperature-sensitive mutations in Drosophila melanogaster. IX. Dominant cold-sensitive lethals on the autosomes.
abstract: Ethyl methanesulfonate-treated autosomes were screened for the presence of dominant cold-sensitive (DCS) lethal mutations in Drosophila melanogaster. None was found among 6,552 treated and 168 untreated third chromosomes. Twenty-three DCS-L chromosomes which caused death at 17 degrees C but survived at 22 degrees C and 29 degrees C were recovered from 5,046 mutagenized chromosome 2's.-The DCS-L mutations all mapped around dp and appeared to be functionally allelic. Lethality of heterozygotes for most of the DCS-L's occurred over a prolonged interval from the embryonic through the larval instars. Prolonged incubation at 17 degrees C did not demonstrate any maternal effect on zygotic survival.
mesh_terms: D000367:Age Factors; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000187:drug effects; D003080:Cold Temperature; D003433:Crosses, Genetic; D003434:Crossing Over, Genetic; D004331:Drosophila melanogaster / Q000254:growth & development*; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D005816:Genetic Complementation Test; D006579:Heterozygote; D007247:Infertility, Female; D007814:Larva; D008297:Male; D008722:Methods; D009154:Mutation; D011679:Pupa; D013451:Sulfonic Acids / Q000494:pharmacology; D013696:Temperature
chemical_list: D013451:Sulfonic Acids