Distribution of neuraminidase and n-acetylneuraminate lyase activities among corynebacteria, mycobacteria, and nocardias.
In Corynebacterium diphtheriae and closely related neuraminidase-producing corynebacteria, we have found an N-acetylneuraminate (NAN) lyase activity which cleaves NAN into N-acetyl-d-mannosamine and, presumably, pyruvate. In vitro, these lyases can be shown to synthesize NAN. A survey of representative corynebacteria, "plant pathogenic corynebacteria," mycobacteria, and nocardias revealed that only those corynebacteria closely related to C. diphtheriae exhibited both neuraminidase and NAN lyase activities.
D002474:Cell-Free System; D002854:Chromatography, Paper; D003352:Corynebacterium / Q000201:enzymology* / Q000378:metabolism; D003353:Corynebacterium diphtheriae / Q000201:enzymology / Q000378:metabolism; D006595:Hexosamines / Q000096:biosynthesis; D008358:Mannose; D009161:Mycobacterium / Q000201:enzymology* / Q000378:metabolism; D009163:Mycobacterium bovis / Q000201:enzymology / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000201:enzymology / Q000378:metabolism; D009438:Neuraminic Acids / Q000096:biosynthesis / Q000378:metabolism; D009439:Neuraminidase / Q000378:metabolism*; D009615:Nocardia / Q000201:enzymology* / Q000378:metabolism; D009616:Nocardia asteroides / Q000201:enzymology / Q000378:metabolism; D007652:Oxo-Acid-Lyases / Q000378:metabolism*; D011773:Pyruvates / Q000096:biosynthesis; D013045:Species Specificity
D006595:Hexosamines; D009438:Neuraminic Acids; D011773:Pyruvates; D009439:Neuraminidase; D007652:Oxo-Acid-Lyases; D008358:Mannose