title: Role of drug metabolism in drug research and development: basic considerations.
mesh_terms: D000284:Administration, Oral; D000584:Amiloride / Q000378:metabolism; D000818:Animals; D001646:Bile / Q000378:metabolism; D002247:Carbon Isotopes; D004232:Diuretics / Q000378:metabolism; D004285:Dogs; D005243:Feces / Q000032:analysis; D006168:Guinea Pigs; D006207:Half-Life; D006218:Halofenate / Q000008:administration & dosage / Q000097:blood / Q000652:urine; D000882:Haplorhini; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000652:urine; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D012106:Research
chemical_list: D002247:Carbon Isotopes; D004232:Diuretics; D004364:Pharmaceutical Preparations; D000584:Amiloride; D006218:Halofenate; D007213:Indomethacin