Ragweed hay fever: genetic control and linkage to HL-A haplotypes.
Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgE antibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.
D000293:Adolescent; D000328:Adult; D000485:Allergens; D000917:Antibody Formation; D002648:Child; D005260:Female; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D006801:Humans; D007114:Immunization; D007125:Immunogenetics; D007073:Immunoglobulin E; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics* / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D006649:Histocompatibility Antigens; D007073:Immunoglobulin E