[An ultrastructural research of pancreatic islets in sodium nitrite poisoned rabbits (author's transl)].
Following a biochemical and histological study, the pathogenic effects of the sodium nitrite were investigated by the electron microscope. The vasodilator effect of the nitrite causes in the islets edema and dilatation of the sinusoids. We suppose that the increased afflux of blood could favour the secretion of granules till the exhaustion of cells. Moreover, the endoplasmic reticulum becomes more and more homogeneous and finally he loses its characteristic structure. We observed, at last, that the number of pancreatic islets in the poisoned animals is lower than in control animals.
D000818:Animals; D004721:Endoplasmic Reticulum; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D009573:Nitrites / Q000506:poisoning*; D011817:Rabbits; D012964:Sodium / Q000506:poisoning*
D009573:Nitrites; D012964:Sodium
Ricerca sull'ultrastruttura delle isole pancreatiche in conigli sottoposti ad intossicazione subacuta di sodio nitrito