Stimulation of rabies vaccine in mice by low doses of polyadenylic:polyuridylic complex.
Addition of 100 mug of polyadenylic: polyuridylic (poly A:U) complex to each dose of inactivated rabies vaccine increased immunity to rabies challenge in mice. Stimulation was also observed after addition of 10 mug of poly A:U to the vaccines. Mixtures of rabies vaccine and poly A:U lost their stimulatory properties after storage at 37 or 4 C for 1 month. However, these data are encouraging for practical use of poly A:U as an adjuvant to viral vaccines.
D000276:Adjuvants, Immunologic; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000187:drug effects; D004356:Drug Storage; D005260:Female; D005856:Germ-Free Life; D007369:Interferon Inducers / Q000494:pharmacology*; D051379:Mice; D011063:Poly A-U / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D011119:Polynucleotides / Q000494:pharmacology*; D011819:Rabies Vaccines / Q000494:pharmacology*; D013268:Stimulation, Chemical
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D011119:Polynucleotides; D011819:Rabies Vaccines; D011063:Poly A-U