title: Serum  -macroglobulins in renal disease and preeclampsia.
abstract: The serum levels of alpha(2)-macroglobulin and pregnancy-associated globulin (another alpha-macroglobulin) have been measured by means of a radial immunodiffusion technique in (1) renal disease with and without proteinuria, (2) in age- and sex-matched controls, (3) in preeclampsia with and without proteinuria, and (4) in normal pregnant controls. There are significant increases in alpha(2)-macroglobulin and pregnancy-associated globulin in renal disease accompanied by proteinuria but normal levels are found in renal disease without proteinuria. Compared with normal pregnancy, alpha(2)-macroglobulin is significantly raised in preeclampsia with proteinuria but normal in preeclampsia without proteinuria. In contrast, serum pregnancy-associated globulin is significantly reduced in preeclampsia both with and without proteinuria when compared with normal pregnancy.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000097:blood; D006801:Humans; D005779:Immunodiffusion; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications; D008259:Macroglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011507:Proteinuria / Q000150:complications; D011704:Pyelonephritis / Q000097:blood
chemical_list: D008259:Macroglobulins