[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 3. Selected pharmacologic and immunologic findings].
Comparison of the action of TURISYNCHRON and its zinc complex SUISYNCHRON in mice, rats and dogs showed that neither compound interfered with the implantation process in rats. After oral administration, blood concentrations were lower with SUISYNCHRON than with TURISYNCHRON. The zinc complex was broken down in the acid medium of the stomach, and absorbed in the duodinum or in distal segments of the intestine. Metallibure did not affect on phagocytosis not the course of infections with Escherichia coli or Erysipelothrix insidosa. Both compounds had a thymolytic action, which did not mimic the effect of cofticosteriods.
D000305:Adrenal Cortex Hormones; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental; D004285:Dogs; D004347:Drug Interactions; D004889:Erysipelothrix Infections / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D008693:Methallibure / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*; D013950:Thymus Gland / Q000187:drug effects; D015032:Zinc / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D001786:Blood Glucose; D013890:Thiourea; D015032:Zinc; D008693:Methallibure
Pharmakologisch-endokrinologische Befunde bei der Prüfung von TURISYNCHRON und SUISYNCHRON im Tierexperiment. 3. Mitteilung: Ausgewählte pharmakologische und immunologische Befunde