title: Antibacterial activity of nifuratel in urine and serum.
abstract: The minimum inhibitory concentrations of nifuratel for 205 randomly selected isolates from urinary tract infections were tested by tube dilution. Of these, 177 (86.3%) were resistant to more than 6 mug/ml and 140 of 141 (99.3%) strains of Escherichia coli were resistant to more than 3 mug/ml. Urine levels of nifuratel were examined in two groups: one group had 400 mg given once and the other group had 2 g given over 24 hours. In both groups samples of urine were collected every hour for seven hours after the last dose. After one 400-mg dose the maximum urine level achieved by any subject was 2.0 mug/ml and the mean maximum level was 0.75 mug/ml. With the 2 g total dose, the maximum level noted was 4 mug/ml and the mean maximum level was 1.8 mug/ml. No measurable inhibition was noted in any of the blood samples removed at one and a half to two hours after the last dose.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004754:Enterobacter / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014552:Urinary Tract Infections
chemical_list: D010080:Oxazoles