Folate antagonists. 2. 2,4-Diamino-6-((aralkyl and (heterocyclic)methyl)amino)quinazolines, a novel class of antimetabolites of interest in drug-resistant malaria and Chagas' disease.
D000818:Animals; D000963:Antimetabolites / Q000138:chemical synthesis* / Q000627:therapeutic use; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D014355:Chagas Disease / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000627:therapeutic use; D000882:Haplorhini; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D008251:Macaca; D008288:Malaria / Q000188:drug therapy*; D008744:Methylamines / Q000138:chemical synthesis / Q000627:therapeutic use; D051379:Mice; D008826:Microbial Sensitivity Tests; D011799:Quinazolines / Q000138:chemical synthesis* / Q000627:therapeutic use; D012545:Schiff Bases / Q000138:chemical synthesis / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D000963:Antimetabolites; D001593:Benzyl Compounds; D005493:Folic Acid Antagonists; D006571:Heterocyclic Compounds; D008744:Methylamines; D011799:Quinazolines; D012545:Schiff Bases