The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.
D000818:Animals; D002850:Chromatography, Gel; D003864:Depression, Chemical; D005947:Glucose / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology*; D007328:Insulin / Q000096:biosynthesis* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007553:Isotope Labeling; D007930:Leucine / Q000378:metabolism*; D008297:Male; D051379:Mice; D011384:Proinsulin / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology*; D014316:Tritium
D007328:Insulin; D014316:Tritium; D011384:Proinsulin; D014044:Tolbutamide; D007930:Leucine; D005947:Glucose; D005905:Glyburide