Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice.
Among mice of strain SB/Le, homozygous for the mutant genes beige (bg), satin (sa), and white-bellied agouti (A(w)), 70% developed progressive pneumonitis by 6 months of age. Among backcross offspring from an outcross to C57BL/6J-A(w-J), 49% of homozygous beige and 11% of nonbeige genotypes developed pneumonitis by 6 months of age. The evidence indicates that a specific action of the beige gene increases susceptibility to progressive pneumonitis. Lymphadenopathy, including reticulum cell neoplasms and atypical lymphoproliferative lesions, was observed in high incidence in sa+/sa bg males, suggesting a closer association with satin than with beige. Beige mice show giant lysosomal granules in the leukocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle. Strain SB/Le provides a convenient model in a laboratory animal for study of the increased susceptibility to infection analogous to that of the Chediak-Higashi syndrome.
D000367:Age Factors; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000235:genetics / Q000662:veterinary; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011014:Pneumonia / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000235:genetics*; D012737:Sex Factors