Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid.
D000081:Acetamides / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002247:Carbon Isotopes; D002248:Carbon Monoxide / Q000494:pharmacology; D002273:Carcinogens / Q000652:urine; D002854:Chromatography, Paper; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004247:DNA / Q000378:metabolism*; D005449:Fluorenes / Q000378:metabolism*; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000032:analysis; D051381:Rats
D000081:Acetamides; D002247:Carbon Isotopes; D002273:Carcinogens; D005449:Fluorenes; D011506:Proteins; D002248:Carbon Monoxide; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital