Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria.
In preliminary studies with mefloquine (WR 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of Plasmodium falciparum. Development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration.
D000962:Antimalarials / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D008297:Male; D010880:Piperidines / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000627:therapeutic use*; D013045:Species Specificity
D000962:Antimalarials; D010880:Piperidines; D011804:Quinolines