The combination of trimethoprim and sulfamethoxazole in the treatment of urinary tract infection.
In a series of 52 patients the combination of trimethoprim and sulfamethoxazole was used for the treatment of urinary tract infection and the results are analyzed with respect to the clinical diagnosis and bacterial etiology. There was complete agreement between in vitro sensitivity and clinical response except in the case of one strain of Streptococcus fecalis. The combination of drugs was effective against some bacterial strains which were resistant to the commonly used antimicrobial agents.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001437:Bacteriuria / Q000175:diagnosis; D003556:Cystitis / Q000188:drug therapy; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D013293:Enterococcus faecalis / Q000187:drug effects; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D008403:Mass Screening; D011513:Proteus mirabilis / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D011704:Pyelonephritis / Q000188:drug therapy; D011743:Pyrimidines / Q000627:therapeutic use*; D012705:Serratia / Q000187:drug effects; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D014295:Trimethoprim; D013420:Sulfamethoxazole