Inhibitory effects of mitomycin-related compounds lacking the C1-C2 aziridine ring.
Three chemical derivatives of mitomycin C cause loss of viability, inhibition of deoxyribonucleic acid synthesis, and inhibition of cell division in bacteria. Each of these drugs lacks the C(1)-C(2) aziridine ring previously postulated to be essential for the bactericidal effect of mitomycin C.
D001389:Azirines / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008937:Mitomycins / Q000494:pharmacology*
D001389:Azirines; D008937:Mitomycins