6-Hydroxydopa depletion of brain norepinephrine and the function of aggressive behavior.
A significant increase in shock-induced aggression occurs in the rat 4 days after an intraventricular injection of 90 micrograms of 6-hydroxydopa. Both fluorescent histology and biochemical assay demonstrate that brain norepinephrine is reduced by 90 micrograms of 6-hydroxydopa, while brain dopamine remains unaltered. This suggests that one form of aggressive behavior (shock-induced aggression) is modulated through a central noradrenergic system.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004298:Dopamine / Q000032:analysis; D004597:Electroshock; D006651:Histocytochemistry; D006801:Humans; D007031:Hypothalamus / Q000032:analysis; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D012154:Reticular Formation / Q000032:analysis; D013997:Time Factors
D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine