Effect of synthetic bradykinin on contractile tension of human saphenous vein strips.
The ability of synthetic bradykinin to contract isolated, helically-cut human saphenous vein strips was studied in vitro. Bradykinin (0.05-2.0,mug/ml) consistently failed to contract human vein strips. Similarly prepared rabbit aortic strips also failed to contract when exposed to bradykinin in the concentration range studied. Bradykinin-insensitive vein and aortic strips responded with substantial increases in contractile tension when exposed to prostaglandin E(2), noradrenaline, histamine and KC1. However, bradykinin (0.1,mug/ml) was, capable of relaxing human vein strips, which had contracted in response to prostaglandin E(2).
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology; D011817:Rabbits; D012501:Saphenous Vein / Q000187:drug effects*
D011453:Prostaglandins; D011189:Potassium Chloride; D006632:Histamine; D001920:Bradykinin; D009638:Norepinephrine