title: Effect on reproductive organs of three clomiphene analogues.
abstract: 1. The oestrogenic properties of four triphenylethylene compounds were compared. They can be listed as follows in order of their oestrogenic potency: 1-[p-(beta-diethylaminoethoxy)-phenyl]-2-nitro-1,2-diphenylethylene (E.I.P.W. 111) > clomiphene > 1-[p-(beta-dimethylaminoethoxy)-phenyl]-2-nitro-1, 2-diphenylethylene (E.I.P.W. 113)> 1-[p-(beta-diethylaminoethoxy)-phenyl]-1,2-diphenylethylene (E.I.P.W. 103). The oestrogenic potency of compound E.I.P.W. 111 was found to be about 1/10th of that of oestradiol.2. Compound E.I.P.W. 111 is partially antioestrogenic but not progesteronic in nature. It has no androgenic effect.
mesh_terms: D000818:Animals; D002996:Clomiphene / Q000008:administration & dosage / Q000494:pharmacology*; D004123:Dimethylamines / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D004965:Estrogen Antagonists; D004967:Estrogens / Q000494:pharmacology; D004987:Ethers / Q000494:pharmacology; D005021:Ethylamines / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009574:Nitro Compounds / Q000494:pharmacology; D009929:Organ Size; D011374:Progesterone / Q000494:pharmacology; D011467:Prostate / Q000166:cytology / Q000187:drug effects; D011817:Rabbits; D012669:Seminal Vesicles / Q000166:cytology / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013737:Testis / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
chemical_list: D004123:Dimethylamines; D004965:Estrogen Antagonists; D004967:Estrogens; D004987:Ethers; D005021:Ethylamines; D009574:Nitro Compounds; D013267:Stilbenes; C002666:EIPW 103; D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol