Separation of irritancy from the anti-inflammatory component of inflammation exudate.
The anti-inflammatory component found in inflammation exudates has been purified by Sephadex gel filtration and preparative polyacrylamide electrophoresis. Highly purified material produces no greater irritancy upon injection than 0.9% sodium chloride.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D002351:Carrageenan; D002850:Chromatography, Gel; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004591:Electrophoresis, Polyacrylamide Gel; D005122:Exudates and Transudates; D007249:Inflammation; D007509:Irritants / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D011506:Proteins / Q000302:isolation & purification; D051381:Rats
D000893:Anti-Inflammatory Agents; D007509:Irritants; D011506:Proteins; D002351:Carrageenan