Antibacterial activity of venom alkaloids from the imported fire ant, Solenopsis invicta Buren.
The antibacterial properties of synthetic fire ant venom alkaloids were tested by disc-diffusion procedures against a variety of bacteria and by doubling concentrations in broth cultures of Staphylococcus aureus and Escherichia coli. Gram-positive bacteria were inhibited by lower concentrations of trans-2-methyl-6-n-undecylpiperidine, trans-2-methyl-6-n-tridecylpiperidine, and trans-2-methyl-6-n-pentadecylpiperidine than were gram-negative bacteria. A fourth alkaloid, trans-2-methyl-6-(cis-6-pentadecenyl)piperidine, which was available in minute quantity and was tested by disc-diffusion only, was ineffective against all organisms.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001000:Ants; D001407:Bacillus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014688:Venoms / Q000494:pharmacology*
D000470:Alkaloids; D014688:Venoms