title: Tilorone hydrochloride: lack of correlation between interferon induction and viral protection.
abstract: The protection of mice against MM virus infection and the induction of circulating interferon by tilorone hydrochloride were determined. Whereas protection was evident with doses of 0.15 and 1.5 mg/kg, interferon was not detected with doses lower than 150 mg/kg. Protection was apparently not dependent on interferon induction.
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D004048:Diethylamines / Q000494:pharmacology; D004660:Encephalitis / Q000517:prevention & control; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D009205:Myocarditis / Q000517:prevention & control
chemical_list: D000998:Antiviral Agents; D004048:Diethylamines; D005449:Fluorenes; D007369:Interferon Inducers; D007372:Interferons