title: Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation.
abstract: Sch 14342 is an aminoglycoside antibiotic coproduced as a minor component in the gentamicin fermentation. Sch 14342 was found to have the same antibacterial spectrum as gentamicin in vitro and in vivo, and was approximately one-third as active in mouse protection tests. Sch 14342 relative to gentamicin was one-third as toxic in acute tests in mice, one-eighth as toxic in renal toxicity tests in dogs, and an estimated one-tenth as toxic in cat ataxia tests. Sch 14342 possesses a significantly improved therapeutic index relative to gentamicin with reference to ataxia potential and renal toxicity.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001424:Bacterial Infections / Q000517:prevention & control; D002415:Cats; D005285:Fermentation; D005839:Gentamicins / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins