Failure of glucagon release in infants of diabetic mothers.
Two hours after birth 30 normal infants had a fall in blood glucose of 20.6 mg/100 ml and a rise of plasma pancreatic glucagon of 50.7 pg/ml. Fifteen infants of diabetic mothers treated with insulin had a much greater fall in blood glucose of 77.5 mg/100 ml and a smaller rise of glucagon of 20.9 pg/ml. By comparison 14 small-for-dates infants, who are also prone to hypoglycaemia, had a blood glucose fall of 32.8 mg/100 ml and a larger rise of pancreatic glucagon of 96.0 pg/ml. It is suggested that the impaired pancreatic glucagon rise in the infants of diabetic mothers may be a significant factor in their hypoglycaemia.
D001724:Birth Weight; D001786:Blood Glucose; D005260:Female; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood; D007328:Insulin / Q000009:adverse effects / Q000627:therapeutic use; D008659:Metabolic Diseases / Q000097:blood; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy; D011863:Radioimmunoassay; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon