The Kmif (Kveim-induced macrophage migration inhibition factor) test in sarcoidosis.
Circulating lymphocytes from 30 patients with sarcoidosis when stimulated in vitro with Kveim-induced macrophage migration factor, the Kmif test, produced a guinea-pig macrophage migration inhibition factor in 21 of 30 cases (70%). In those patients not on steroids the results showed a good correlation with the cutaneous Kveim test. One positive test was found in 16 normal subjects. Our results suggest that the Kmif test may prove a useful rapid alternative to the Kveim test.
D000328:Adult; D000368:Aged; D000818:Animals; D000941:Antigens; D002464:Cell Migration Inhibition; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008198:Lymph Nodes; D008214:Lymphocytes; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008722:Methods; D008875:Middle Aged; D012507:Sarcoidosis / Q000175:diagnosis / Q000276:immunology*; D012882:Skin Tests
D000941:Antigens