title: A study of the localization of polynucleotide phosphorylase within rat liver cells and of its distribution among rat tissues and diverse animal species.
abstract: 1. Rat liver polynucleotide phosphorylase was localized in the mitochondrion, but may also occur in the nucleus. 2. The mitochondrial enzyme was found in rat heart, kidney, liver, muscle and spleen. 3. Mitochondrial polynucleotide phosphorylase is also present in calf, chicken, guinea-pig and rabbit liver and in goldfish muscle. 4. A possible physiological role for the enzyme in the control of the intramitochondrial ADP concentration is suggested.
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002458:Cell Fractionation; D002467:Cell Nucleus / Q000201:enzymology; D002645:Chickens; D003530:Cyprinidae; D006168:Guinea Pigs; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D008931:Mitochondria, Muscle / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D009995:Osmosis; D010759:Phosphorus Isotopes; D011117:Polyribonucleotide Nucleotidyltransferase / Q000032:analysis; D012316:RNA Nucleotidyltransferases / Q000032:analysis*; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000201:enzymology
chemical_list: D010759:Phosphorus Isotopes; D000244:Adenosine Diphosphate; D012316:RNA Nucleotidyltransferases; D011117:Polyribonucleotide Nucleotidyltransferase