Anaesthetic, cardiovascular and respiratory effects of a new steroidal agent CT 1341: a comparison with other intravenous anaesthetic drugs in the unrestrained cat.
1. The anaesthetic, cardiovascular, respiratory and adverse effects produced by the intravenous injection of CT 1341, thiopentone, methohexitone, pentobarbitone, propanidid and ketamine have been compared in unrestrained cats prepared with chronically implanted venous and arterial cannulae. Aortic blood pressure and heart rates were monitored before, during and after loss of consciousness.2. CT 1341 produced rapid induction of anaesthesia followed by moderately rapid recovery, was active over a wide range of doses and caused minimal respiratory depression and few adverse effects. It caused an initial short-lasting tachycardia and fall in aortic blood pressure succeeded by a secondary depressor response.3. The safety margin was narrower with the barbiturate drugs than with CT 1341, and large doses induced apnoea and respiratory depression. Small doses of methohexitone elicited excitatory effects and large doses caused severe respiratory and circulatory depression, and recovery from anaesthesia was protracted.4. Propanidid induced short-lasting light anaesthesia. The safety margin was narrowest with this drug and induction was associated with adverse circulatory, respiratory and other effects.5. Ketamine was active over a wide range of doses but exhibited qualitatively different properties from the other anaesthetics. Induction was slower after small doses and these produced circulatory stimulation, catatonia and bizarre behavioural effects. Large doses caused respiratory and circulatory depression and recovery was protracted.6. It is concluded that CT 1341 has a wider therapeutic latitude, produces less respiratory depression and has other advantages over the currently used intravenous anaesthetics.
D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002415:Cats; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology; D007659:Ketones / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D008723:Methohexital / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D011278:Pregnanes / Q000494:pharmacology* / Q000633:toxicity; D011410:Propanidid / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects*; D013874:Thiopental / Q000494:pharmacology
D000777:Anesthetics; D007659:Ketones; D011278:Pregnanes; D007649:Ketamine; D011410:Propanidid; D008723:Methohexital; D010424:Pentobarbital; D013874:Thiopental