The specificity of dipeptidyl aminopeptidase I (cathepsin C) and its use in peptide sequence studies.
1. The characterization of cathepsin C as an aminodipeptidase has been confirmed. 2. An extra limitation on its specificity, namely that peptides involving proline as the third residue are immune to the enzyme, has been found. 3. A novel technique of using the enzyme for amino acid sequence determination has been shown to be feasible.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002403:Cathepsins / Q000302:isolation & purification*; D002417:Cattle; D004586:Electrophoresis; D010441:Peptide Chain Elongation, Translational; D010455:Peptides / Q000032:analysis*; D013223:Statistics as Topic
D000596:Amino Acids; D010455:Peptides; D002403:Cathepsins