Effect of phenobarbital and 3,4-benzpyrene treatment of rats on the microsomal binding and hydroxylation of nortriptyline and desmethyl-imipramine: evidence for qualitative changes in cytochrome P-450-ligand interaction following phenobarbital pretreatment.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D001665:Binding Sites; D002849:Chromatography, Gas; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003891:Desipramine / Q000378:metabolism*; D006591:Hexobarbital / Q000494:pharmacology; D008024:Ligands; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009661:Nortriptyline / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects*; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors; D014316:Tritium
D001580:Benzopyrenes; D008024:Ligands; D011955:Receptors, Drug; D014316:Tritium; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D009661:Nortriptyline; D006899:Mixed Function Oxygenases; D003891:Desipramine; D010634:Phenobarbital