Cholesterol: vitamin C controls its transformation to bile acids.
Cholesterol accumulates in the blood serum and in the liver of guinea pigs with chronic latent vitamin C deficiency. The reason for this is the decreased rate of transformation of cholesterol to bile acids in the liver of animals deficient in vitamin C. A significant direct correlation exists between the vitamin C concentration in the liver and the rate of cholesterol transformation to bile acids.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001206:Ascorbic Acid Deficiency / Q000378:metabolism; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D001711:Biotransformation; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D006168:Guinea Pigs; D008099:Liver / Q000378:metabolism; D008297:Male; D013154:Spleen / Q000378:metabolism
D001647:Bile Acids and Salts; D002247:Carbon Isotopes; D002245:Carbon Dioxide; D002784:Cholesterol; D001205:Ascorbic Acid