title: Two new antimetabolites of biotin: alpha-methyldethiobiotin and alpha-methylbiotin.
abstract: Two new antimetabolites of biotin were isolated from culture filtrates of Streptomyces lydicus: beta-methyldethiobiotin and beta-methylbiotin. (14)C-biotin or (14)C-pimelic acid was not incorporated into either of these antimetabolites by the growing culture. Neither of the compounds could substitute for the biotin requirement in Saccharomyces cerevisiae. Both compounds had a strong and rather specific antimicrobial effect against mycobacteria. Their antimicrobial activities were reversed by biotin. Both compounds had an affinity for avidin.
mesh_terms: D000963:Antimetabolites / Q000302:isolation & purification* / Q000378:metabolism; D001710:Biotin / Q000031:analogs & derivatives* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000963:Antimetabolites; C010224:alpha-methylbiotin; C010228:alpha-methyldethiobiotin; D001710:Biotin