Anticoagulant-resistant rats: possible control by the use of the chloro analog of vitamin K 1 .
Strains of wild rats that are resistant to the anticoagulant action of coumarins and derivatives of indandione have been discovered in a number of geographic areas. These rats have now been shown to be more susceptible than normal rats are to the anticoagulant action of the vitamin K antagonist, 2-chloro-3-phytyl-1,4-naphthoquinone. This compound, either alone or in combination with warfarin, would appear to be an effective rodenticide in areas where resistance to the indirect anticoagulants is a problem.
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D002713:Chlorine / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D009285:Naphthoquinones / Q000494:pharmacology*; D051381:Rats; D012378:Rodenticides / Q000494:pharmacology*; D014812:Vitamin K / Q000037:antagonists & inhibitors*; D014859:Warfarin / Q000494:pharmacology
D000925:Anticoagulants; D009285:Naphthoquinones; D012378:Rodenticides; D014812:Vitamin K; D002713:Chlorine; D014859:Warfarin