title: Histocompatibility-linked genetic control of disease susceptibility. Murine lymphocytic choriomeningitis virus infection.
abstract: Acute necrotizing inflammatory disease after intracerebral injection of LCM virus is largely dependent on the host immune response to the virus and is controlled, in part, by a dominant gene which is closely linked to the H-2 locus. The F(1) hybrid (H-2(q/k)) from mating a susceptible SWR/J mouse (H-2(q/q)) to a resistant C3H/HeJ mouse (H-2(k/k)) is susceptible to LCM virus disease. When such hybrids (H-2(q/k)) are backcrossed to susceptible parents (H-2(q/q)), all F(2) offspring (H-2(q/q), H-2(q/k)) are highly susceptible. In contrast, hybrid (H-2(q/k)) backcross to resistant parents (H-2(k/k)) results in half of the F(2) offspring being susceptible (H-2(q/k)) while the other half are resistant (H-2(k/k)). Similarly, in congenic H-2(q/q) and H-2(k/k) mice, H-2(q/q) mice are relatively susceptible to acute LCM disease, whereas H-2(k/k) are resistant.
mesh_terms: D000327:Adsorption; D000483:Alleles; D000818:Animals; D001921:Brain / Q000473:pathology; D002478:Cells, Cultured; D003433:Crosses, Genetic; D004622:Embryo, Mammalian; D005260:Female; D005799:Genes, Dominant; D006648:Histocompatibility; D007267:Injections; D008216:Lymphocytic Choriomeningitis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008217:Lymphocytic choriomeningitis virus / Q000254:growth & development / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains