Electrocardiogram monitoring: computerized detection of ventricular changes induced by drugs.
Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.
D000818:Animals; D003201:Computers; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology; D008722:Methods; D051379:Mice; D008991:Monitoring, Physiologic; D010042:Ouabain / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology
D010042:Ouabain; D010672:Phenytoin; D008012:Lidocaine