The respiratory action of phenyl diguanide in vagotomized rabbits.
In anaesthetized rabbits phenyl diguanide not only stimulates breathing (rapid shallow breathing) by a vagal reflex from lung J-receptors, but also causes a similar response in bilateral vagotomized animals. Injection of the drug into different parts of the circulation indicates that the main non-vagal response of breathing arises from areas supplied by the vertebral arteries, presumably in the brain.
D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D006985:Hyperventilation / Q000139:chemically induced; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D001645:Biguanides