title: Pyrethroid insecticides: esterase cleavage in relation to selective toxicity.
abstract: The ester group of primary alcohol chrysanthemates is cleaved by mouse hepatic microsomal esterases, more rapidly for the (+)-trans than for the (+)-cis isomers. Substrate-specificity and inhibition studies in vivo establish that these pyrethroid-hydrolyzing esterases probably contribute to the low mammalian toxicity of bioresmethrin and other (+)-trans chrysanthemate insecticide chemicals derived from primary alcohols.
mesh_terms: D000818:Animals; D011723:Chrysanthemum cinerariifolium / Q000378:metabolism / Q000633:toxicity*; D004357:Drug Synergism; D004950:Esterases / Q000378:metabolism*; D006868:Hydrolysis; D007928:Lethal Dose 50; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*; D010756:Phosphoric Acids / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D010756:Phosphoric Acids; D004950:Esterases