Metabolism of iphosphamide (2-(2-chloroethylamino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) and production of a toxic iphosphamide metabolite.
D000445:Aldehyde Oxidoreductases; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism* / Q000652:urine; D002247:Carbon Isotopes; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D003498:Cyclic P-Oxides / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000378:metabolism; D004285:Dogs; D005021:Ethylamines / Q000138:chemical synthesis / Q000378:metabolism / Q000652:urine; D005260:Female; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D013058:Mass Spectrometry; D051379:Mice; D008811:Mice, Inbred DBA; D008862:Microsomes, Liver / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000378:metabolism* / Q000652:urine; D010078:Oxazines / Q000138:chemical synthesis / Q000378:metabolism* / Q000652:urine; D010084:Oxidation-Reduction; D011817:Rabbits
D000970:Antineoplastic Agents; D002247:Carbon Isotopes; D003498:Cyclic P-Oxides; D005021:Ethylamines; D009943:Organophosphorus Compounds; D010078:Oxazines; D003520:Cyclophosphamide; D000445:Aldehyde Oxidoreductases