Increased antitumour activity of chlorambucil following pretreatment with inducers of drug-metabolizing enzymes.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D002699:Chlorambucil / Q000378:metabolism / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000032:analysis; D004351:Drug Resistance; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D066298:In Vitro Techniques; D008748:Methylcholanthrene / Q000494:pharmacology*; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010634:Phenobarbital / Q000494:pharmacology*; D011292:Premedication; D012334:RNA, Neoplasm / Q000032:analysis; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy; D014184:Transplantation, Homologous
D001551:Benz(a)Anthracenes; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D002699:Chlorambucil; D008748:Methylcholanthrene; D010634:Phenobarbital