title: Electrocardiogram monitoring: computerized detection of ventricular changes induced by drugs.
abstract: Cardiac arrhythmia was induced in mice by the injection of ouabain, lidocaine, and diphenylhydantoin. Temporal spreading of ventricular electrocardiographic complexes is shown consistently to follow injection of a cardioactive drug and to precede rhythm disturbances. A computerized monitoring technique based on temporal spreading and waveform distortion should find wide clinical and experimental application.
mesh_terms: D000818:Animals; D003201:Computers; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology; D008722:Methods; D051379:Mice; D008991:Monitoring, Physiologic; D010042:Ouabain / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology
chemical_list: D010042:Ouabain; D010672:Phenytoin; D008012:Lidocaine