Spinal cord blood flow in dogs. 2. The effect of the blood gases.
The effect of CO(2) on the spinal cord blood flow was investigated in nine dogs. The flow was closely correlated with the paCO(2) and at about 85 mmHg was double the normocarbic flow. The effect of pO(2) was studied in a further nine dogs. Hypoxia markedly increased the flow which was maximal at paO(2) 30-40 mmHg. The vasoconstrictor effect of hypocarbia was absent or decreased in hypoxia. The response of the cord vessels to the blood gases was very similar to that of the brain.
D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D012039:Regional Blood Flow / Q000187:drug effects; D013116:Spinal Cord / Q000098:blood supply*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014978:Xenon
D014662:Vasoconstrictor Agents; D002245:Carbon Dioxide; D014978:Xenon; D010100:Oxygen