BCG immunotherapy of pulmonary growths from intravenously transferred rat tumour cells.
Pulmonary growths produced by intravenous injection of methycholanthrene-induced sarcoma cells were controlled or suppressed by specific immunostimulation with BCG-sarcoma cell inocula at subcutaneous sites or by intravenous treatment with BCG alone. The response was dependent upon the immunogenicity of the treated tumour so that in comparison, intravenous injection of BCG enhanced rather than suppressed pulmonary growths of transferred cells of several weakly immunogenic tumours including a spontaneously arising sarcoma and an epithelioma as well as a carcinogen-induced mammary carcinoma.
D000276:Adjuvants, Immunologic; D000818:Animals; D001500:BCG Vaccine; D007167:Immunotherapy; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000628:therapy*; D008325:Mammary Neoplasms, Experimental / Q000276:immunology; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D051381:Rats; D012509:Sarcoma / Q000276:immunology; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D008748:Methylcholanthrene