Electrogenic sodium pump in squid giant axon.
Squid giant axon possesses a hyperpolarizing electrogenic sodium pump which is stimulated by internal sodium and by external potassium. This conclusion is based on the following observations: strophanthidin depolarizes the membrane and enhances the depolarizing effect of 5 or 10 millimolar external potassium; the magnitude of these effects is directly related to the internal sodium concentration; both effects are abolished by cyanide.
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000378:metabolism*; D003080:Cold Temperature; D049832:Decapodiformes; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D012964:Sodium / Q000378:metabolism*; D012975:Sodium Isotopes; D013328:Strophanthins / Q000494:pharmacology
D012975:Sodium Isotopes; D013328:Strophanthins; D008094:Lithium; D012964:Sodium