Acute renal failure associated with combined gentamicin and cephalothin therapy.
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6 mg/kg/day) was in the normal range, but that of cephalothin (180 mg/kg/day) was abnormally high. The nephropathy was of the tubular-interstitial type and the clinical picture similar to that seen in acute drug-induced nephropathies. Frusemide was given only after the onset of renal failure. In these three patients the high intravenous doses of cephalothin combined with gentamicin were probably nephrotoxic.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000328:Adult; D002512:Cephalothin / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004347:Drug Interactions; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D014508:Urea / Q000097:blood
D005839:Gentamicins; D005665:Furosemide; D014508:Urea; D003404:Creatinine; D002512:Cephalothin