Aplastic anemia associated with lithium therapy.
A case is reported of fatal aplastic anemia developing in a 50-year-old woman who received lithium carbonate in the generally accepted dosage for a manic-depressive disorder. The serum lithium had been determined at regular intervals and never exceeded what is considered a safe level. Patients for whom lithium is prescribed should have periodic hematologic examinations.
D000741:Anemia, Aplastic / Q000097:blood / Q000139:chemically induced* / Q000150:complications / Q000401:mortality; D001714:Bipolar Disorder / Q000188:drug therapy; D002254:Carbonates / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D007958:Leukocyte Count; D008094:Lithium / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008875:Middle Aged; D012871:Skin Diseases / Q000209:etiology; D013881:Thioridazine / Q000627:therapeutic use
D002254:Carbonates; D006454:Hemoglobins; D008094:Lithium; D013881:Thioridazine; D007099:Imipramine