title: Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity.
abstract: In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001806:Blood Urea Nitrogen; D004285:Dogs; D004952:Esters; D005919:Glomerular Filtration Rate; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007668:Kidney / Q000098:blood supply; D007684:Kidney Tubules / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051381:Rats
chemical_list: D004952:Esters; D000666:Amphotericin B