A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. 3. Accumulation of acid soluble collagen with a high hydroxylysine content in bone.
D000447:Aldehydes / Q000032:analysis; D000596:Amino Acids / Q000032:analysis; D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002498:Centrifugation; D002845:Chromatography; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism*; D003720:Densitometry; D004591:Electrophoresis, Polyacrylamide Gel; D006601:Hexoses / Q000032:analysis; D006901:Hydroxylysine / Q000032:analysis; D009904:Optical Rotation; D009905:Optical Rotatory Dispersion; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D014783:Viscosity
D000447:Aldehydes; D000596:Amino Acids; D006601:Hexoses; D000629:Aminopropionitrile; D006901:Hydroxylysine; D003094:Collagen; D010396:Penicillamine