Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N'-bis(3-aminopropyl)nonane-1,9-diamine.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002277:Carcinoma; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009062:Mouth Neoplasms; D011437:Propylamines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013096:Spermine / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011437:Propylamines; D013096:Spermine