The conversion of the pyrrolizidine alkaloid retrorsine to pyrrolic derivatives in vivo and in vitro and its acute toxicity to various animal species.
D000818:Animals; D001717:Birds; D002417:Cattle; D006224:Cricetinae; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011758:Pyrroles / Q000096:biosynthesis* / Q000378:metabolism; D011763:Pyrrolizidine Alkaloids / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D011784:Quail; D051381:Rats; D012756:Sheep; D013045:Species Specificity; D013997:Time Factors
D011758:Pyrroles; D011763:Pyrrolizidine Alkaloids; D010634:Phenobarbital