Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
D000818:Animals; D001555:Benzene Derivatives; D001966:Bromine; D056486:Chemical and Drug Induced Liver Injury; D004790:Enzyme Induction; D005978:Glutathione / Q000378:metabolism; D006846:Hydrocarbons, Halogenated / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism; D046911:Macromolecular Substances; D008297:Male; D008298:Maleates / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009336:Necrosis / Q000139:chemically induced*; D009570:Nitriles / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D010882:Piperonyl Butoxide / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D011485:Protein Binding; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats
D001555:Benzene Derivatives; D006846:Hydrocarbons, Halogenated; D046911:Macromolecular Substances; D008298:Maleates; D009570:Nitriles; D011720:Pyrazoles; D011335:Proadifen; D005978:Glutathione; D010882:Piperonyl Butoxide; D001966:Bromine; D010634:Phenobarbital