Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man.
A relatively small proportion (17 percent) of individuals highly allergic to ragweed were found to develop marked reaginic (immunoglobulin E-mediated) skin sensitivity to a minor ragweed pollen allergen Ra5 (molecular weight 5200). Sensitivity to Ra5 was significantly associated with the possession of a major histocompatibility antigen of the HL-A7 cross-reacting group. This appears to be the first evidence of a strong association between a specific immune response and a specific group of closely related HL-A antigens in man.
D000917:Antibody Formation; D044383:Black People; D003429:Cross Reactions; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D006650:Histocompatibility Testing; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007073:Immunoglobulin E; D011058:Pollen; D012882:Skin Tests; D044465:White People
D006649:Histocompatibility Antigens; D007073:Immunoglobulin E