title: Regulation of bile salt pool size in man.
abstract: When the enterohepatic circulation is intact the size of the bile salt pool is largely determined by the frequency of its enterohepatic circulation. This hypothesis, derived from studies of cholate kinetics in coeliac, cholecystectomy, and gall stone patients, represents the simplest interpretation of the data. A corollary is that daily cholate secretion is likely to be normal in these conditions and that therefore the propensity of bile to form cholesterol gall stones is not likely to be directly related to bile salt pool size.
mesh_terms: D001646:Bile / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002446:Celiac Disease / Q000378:metabolism; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000378:metabolism; D002793:Cholic Acids / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D013656:Taurocholic Acid / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D002793:Cholic Acids; D013656:Taurocholic Acid