Amodiaquine-induced agranulocytosis: toxic effect of amodiaquine in bone marrow cultures in vitro.
A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro. This technique should be investigated in other patients with agranulocytosis as a possible means of detecting toxic agents.
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D000655:Amodiaquine / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001773:Blood Cells; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002452:Cell Count; D002481:Cellulitis / Q000188:drug therapy; D046508:Culture Techniques; D005260:Female; D006801:Humans; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000655:Amodiaquine