Production of TL antibody by mice immunized with TL- cell populations. A possible assay for thymic hormone.
TL(-) mice make TL antibody when immunized with spleen or bone marrow cells from TL(+) donors, despite the fact that these cells do not express TL antigen. This has been shown to depend on maturation of TL(-) precursors, contained in the inoculum, into TL(+) cells under influence of the recipient's thymus; the differentiated TL(+) cells then evoke production of TL antibody.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D007114:Immunization; D007942:Leukemia, Experimental / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*
D000941:Antigens