title: Variable sex chromatin pattern in an early carcinoma of the bladder.
abstract: Sex chromatin studies on squash preparations of a well differentiated transitional cell carcinoma of the bladder without evidence of invasion from a female aged 63 revealed a single body in some regions, but two to four bodies in others. All regions were near diploid according to DNA estimations. Previous observations on a variety of invasive tumours of females showed that the presence of more than one sex chromatin body is generally associated with a high chromosome number. The pattern of two or more bodies in near-diploid cells seen in this non-invasive tumour may therefore characterize an intermediate stage of clonal evolution, eventually resulting in malignancy, when the cell line has not yet achieved the ability to invade or metastasize.
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000473:pathology; D002460:Cell Line; D002999:Clone Cells; D004273:DNA, Neoplasm / Q000032:analysis; D004171:Diploidy; D005260:Female; D006801:Humans; D008875:Middle Aged; D008938:Mitosis; D009362:Neoplasm Metastasis; D012728:Sex Chromatin; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm