The effect of chronic sodium loading and sodium restriction on plasma prostaglandin A, E, and F concentrations in normal humans.
It has been suggested that prostaglandins may be involved in the control of sodium homeostasis. Prostaglandin A and prostaglandin E have been shown to increase renal blood flow and urinary sodium excretion and prostaglandin A has been shown to stimulate aldosterone release. The purpose of this study was to determine the effect of chronic sodium loading and sodium restriction on plasma prostaglandin A, E, and F concentrations. SEVEN NORMAL HUMAN VOLUNTEERS WERE PLACED ON THREE SODIUM INTAKE DIETS: (a) ad lib. sodium intake, (b) high sodium intake, and (c) low sodium intake. Plasma prostaglandin A, E, and F concentrations were measured by radioimmunoassay. Mean prostaglandin A levels on the ad lib. diet were 1.60 ng/ml. Prostaglandin A levels decreased 49% to 0.82 ng/ml on the high sodium intake and increased 34% to 2.14 ng/ml on the low sodium intake. Prostaglandin A levels increased 161% on the low sodium diet in comparison with levels on the high sodium diet. Plasma prostaglandin E and F concentrations did not change significantly during variation in sodium intake. These results show that dietary sodium content markedly effects plasma prostaglandin A levels and that prostaglandins may play a role in the physiologic mechanism of sodium homeostasis.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D004032:Diet; D005260:Female; D006706:Homeostasis; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D011188:Potassium / Q000097:blood; D011453:Prostaglandins / Q000097:blood*; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology*; D012965:Sodium Chloride / Q000008:administration & dosage
D011453:Prostaglandins; D012965:Sodium Chloride; D012964:Sodium; D012083:Renin; D011188:Potassium