New pathway for nonphosphorylated degradation of gluconate by Aspergillus niger.
A new nonphosphorylative pathway for gluconate degradation was found in extracts of a strain of Aspergillus niger. The findings indicate that gluconate is dehydrated into 2-keto-3-deoxy-gluconate (KDG), which then is cleaved into glyceraldehyde and pyruvate. 6-Phosphogluconate was not degraded under the same conditions. In addition, KDG was formed from glyceraldehyde and pyruvate. Very weak activity was obtained when glyceraldehyde 3-phosphate replaced glyceraldehyde in this reaction.
D001230:Aspergillus / Q000254:growth & development / Q000378:metabolism*; D005942:Gluconates / Q000378:metabolism*; D005985:Glyceraldehyde / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D005942:Gluconates; D011773:Pyruvates; D005985:Glyceraldehyde