Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine.
D000630:Aminopterin / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D003857:Deoxyuridine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism; D007421:Intestine, Small / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism*; D008745:Methylation; D051379:Mice; D011799:Quinazolines / Q000008:administration & dosage / Q000378:metabolism*
D005493:Folic Acid Antagonists; D011799:Quinazolines; D004247:DNA; D000630:Aminopterin; D003857:Deoxyuridine; D008727:Methotrexate