title: Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.
abstract: A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000941:Antigens; D002531:Cerebellum / Q000032:analysis; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007031:Hypothalamus / Q000032:analysis*; D010455:Peptides / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000502:physiology; D011863:Radioimmunoassay; D051381:Rats; D012756:Sheep; D014020:Tissue Extracts / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000941:Antigens; D010455:Peptides; D014020:Tissue Extracts; D013006:Growth Hormone