title: Delta-9-tetrahydrocannabinol: localization in body fat.
abstract: [(14)C]Delta(9)-Tetrahydrocannabinol (Delta(9)THC) was injected subcutaneously in rats every day for 1 to 26 days. Concentrations of Delta(9)THC and its metabolites, 11-hydroxytetrahydrocannabinol and 8,11-dihydroxytetrahydrocannabinol, were determined in various tissues. After a single injection, the concentration of Delta(9)THC in fat was ten times greater than in any other tissue examined, and persisted in this tissue for 2 weeks. With repeated injection, Delta(9)THC and its metabolites accumulated in fat and brain.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002188:Cannabis / Q000378:metabolism*; D002247:Carbon Isotopes; D013759:Dronabinol / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D007279:Injections, Subcutaneous; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051381:Rats
chemical_list: D002247:Carbon Isotopes; D013759:Dronabinol