title: Specific inhibitors of ammonia oxidation in Nitrosomonas.
abstract: The following compounds or treatments have been shown to inhibit the oxidation of ammonia, but not the oxidation of hydroxylamine in cells of Nitrosomonas: (i) metal-binding agents such as allylthiourea or potassium cyanide; (ii) compounds such as SKF 525 which interact with cytochrome P-450 of mammalian microsomes; (iii) carbon monoxide; (iv) inhibitors of catalase, peroxidase, and amine oxidases such as thiosemicarbazide, ethylxanthate, and iproniazid, respectively; (v) uncouplers of oxidative phosphorylation such as m-chlorocarbonylcyanidephenylhydrazone; (vi) electron acceptors such as phenazine methosulfate; (vii) compounds such as methanol or N(2)O which react with free radicals; and (viii) illumination with 420 lux (5,000 foot candles) of light.
mesh_terms: D000438:Alcohols / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000641:Ammonia / Q000378:metabolism*; D002248:Carbon Monoxide / Q000494:pharmacology; D002374:Catalase / Q000037:antagonists & inhibitors; D002474:Cell-Free System; D002614:Chelating Agents / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D006898:Hydroxylamines / Q000378:metabolism; D008025:Ligases / Q000096:biosynthesis; D008027:Light; D000432:Methanol / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors; D009573:Nitrites / Q000096:biosynthesis; D009606:Nitrosomonas / Q000201:enzymology / Q000378:metabolism*; D009609:Nitrous Oxide / Q000494:pharmacology; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000037:antagonists & inhibitors; D010619:Phenazines / Q000494:pharmacology; D013696:Temperature; D014475:Uncoupling Agents / Q000494:pharmacology*
chemical_list: D000438:Alcohols; D000588:Amines; D002614:Chelating Agents; D006898:Hydroxylamines; D008996:Monoamine Oxidase Inhibitors; D009573:Nitrites; D010619:Phenazines; D014475:Uncoupling Agents; D000641:Ammonia; D002248:Carbon Monoxide; D010544:Peroxidases; D002374:Catalase; D008025:Ligases; D009609:Nitrous Oxide; D000432:Methanol