Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin.
The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A.BSA and lipid A.HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.
D000818:Animals; D000941:Antigens; D003429:Cross Reactions; D005260:Female; D006017:Glycolipids; D006801:Humans; D008055:Lipids; D008070:Lipopolysaccharides; D008297:Male; D011135:Polysaccharides, Bacterial; D011749:Pyrogens; D011817:Rabbits; D012475:Salmonella / Q000032:analysis / Q000276:immunology; D012709:Serum Albumin; D012710:Serum Albumin, Bovine
D000941:Antigens; D006017:Glycolipids; D008055:Lipids; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D011749:Pyrogens; D012709:Serum Albumin; D012710:Serum Albumin, Bovine