Retrograde state dependent learning.
Sodium pentobarbital administered intravenously after acquisition in a one-trial passive avoidance task results in state dependent (drug dissociated) learning in male albino rats. Findings have methodological implications for drug-based research and theoretical implications for drug discrimination studies. Predictions based on a stimulus generalization hypothesis are not supported, whereas those based on an information storage hypothesis are supported.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D008568:Memory / Q000187:drug effects*; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D010424:Pentobarbital