title: Actions of levodopa on the blood pressure of conscious rabbits.
abstract: 1. In conscious rabbits, the rapid intravenous injection of levodopa alone does not have any significant effects on the blood pressure in doses up to 10 mg/kg.2. After inhibition of monoamine oxidase, levodopa induces a sustained pressor response.3. This response can be blocked by inhibition of extracerebral decarboxylase.4. Possible mechanisms for these interactions are discussed, together with their therapeutic implications in Parkinsonism.
mesh_terms: D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001794:Blood Pressure / Q000187:drug effects*; D002230:Carbidopa / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
chemical_list: D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D008996:Monoamine Oxidase Inhibitors; D004295:Dihydroxyphenylalanine; D007490:Iproniazid; D002230:Carbidopa