Vitamin B12 and the megaloblastic development.
In patients with vitamin B(12) deficiency, phytohemagglutinin-stimulated cultured lymphocytes had little or no thymidylate synthetase activity. Ample activity was found in such lymphocytes from normal individuals and patients with folic acid deficiency or pernicious anemia in remission. It therefore appears that the megaloblastosis that is associated with vitamin B(12) deficiency is related to low thymidylate synthetase activity.
D000752:Anemia, Pernicious / Q000201:enzymology*; D001854:Bone Marrow Cells; D002247:Carbon Isotopes; D004912:Erythrocytes; D005494:Folic Acid Deficiency / Q000201:enzymology; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D008780:Methyltransferases / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D013940:Thymidylate Synthase / Q000097:blood / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000201:enzymology*
D002247:Carbon Isotopes; D037102:Lectins; D009705:Nucleosides; D008780:Methyltransferases; D013940:Thymidylate Synthase