title: The effect of glucagon on serum gastrin. I. Studies in normal subjects.
abstract: Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean +/- SEM level of 50.3 +/- 6.7 to 9.4 +/- 3.3 pg/ml at 30 minutes after injection, significant at p<0.005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005755:Gastrins / Q000097:blood*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011863:Radioimmunoassay; D012633:Secretin / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D005755:Gastrins; D012633:Secretin; D005934:Glucagon