Hydrophobic interactions between the 5-alkyl group of 2,4-diamino-6-methylpyrimidines and dihydrofolate reductase.
D000473:Alkanes; D000588:Amines; D000818:Animals; D001665:Binding Sites; D002021:Buffers; D005493:Folic Acid Antagonists; D007700:Kinetics; D008968:Molecular Conformation; D011743:Pyrimidines; D012510:Sarcoma 180 / Q000201:enzymology*; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013816:Thermodynamics; D014867:Water
D000473:Alkanes; D000588:Amines; D002021:Buffers; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D014867:Water