Role of delayed hypersensitivity in blastomycosis of mice.
C57BL/6J mice rendered hypersensitive to Blastomyces dermatitidis were protected from the lethal effects of a blastomyces infection. This protection was observed following a lethal intraperitoneal challenge with viable cells 15 days after subcutaneous inoculation with 3.9 x 10(4) viable cells. Delayed hypersensitivity was induced in C57 mice by two injections of Merthiolate-killed cells in adjuvant or by a single injection of viable cells. Development of hypersensitivity was determined at appropriate intervals by footpad injection with killed yeast cells.
D000818:Animals; D000946:Antigens, Fungal; D001758:Blastomyces / Q000276:immunology; D001759:Blastomycosis / Q000276:immunology*; D005657:Fungal Vaccines; D006968:Hypersensitivity, Delayed; D007109:Immunity; D007114:Immunization; D007117:Immunization, Secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D012376:Rodent Diseases / Q000276:immunology; D014613:Vaccines, Attenuated
D000946:Antigens, Fungal; D005657:Fungal Vaccines; D014613:Vaccines, Attenuated