Effects of carbenoxolone sodium on stress-induced gastric damage in rats.
Carbenoxolone sodium was studied to determine its effect against restraint-induced gastric mucosal damage in the rat. Significant anti-ulcer activity was observed following intraperitoneal administration in nonfasted but not in either 24 or 48 h fasted rats. Orally, carbenoxolone had no statistically significant effect in non-fasted rats although the data suggest that it may have afforded some protection. These results indicate that the use of non-fasted rats is most probably a requirement for demonstrating the protective activity of this type of anti-ulcer compound in stressed rat assays.
D000818:Animals; D005215:Fasting; D005260:Female; D005753:Gastric Mucosa; D006035:Glycyrrhiza; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000209:etiology; D010946:Plants, Medicinal; D051381:Rats; D013312:Stress, Physiological / Q000150:complications*; D013386:Succinates / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use*; D013997:Time Factors
D013386:Succinates; D013729:Terpenes