title: Non-restorative surgery in the treatment of Crohn's disease of the large bowel.
abstract: This study gives detailed information on the two principal groups of patients undergoing excisional surgery with a permanent artificial stoma for Crohn's disease of the large bowel. During the years 1952-71, 64 patients were treated by total proctocolectomy and ileostomy and 26 patients by excision of the distal large bowel and colostomy. In the group of patients undergoing proctocolectomy, there were two postoperative and six late deaths. Of the 56 patients alive at the end of the follow-up period (average length of follow-up 8.1 years), four had shown evidence of recurrent disease. In each case this occurred following a staged proctocolectomy and at, or immediately proximal to, the ileostomy: the shortest interval between surgery and recurrence was just under 10 years. AMONG THE PATIENTS TREATED BY EXCISION OF THE DISTAL LARGE BOWEL, THERE WERE TWO UNRELATED LATE DEATHS: with an average duration of follow up of 7.3 years, recurrent disease occurred in only one of the 24 patients alive at the concluding date for this study.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D001466:Barium Sulfate; D003082:Colectomy; D003125:Colostomy; D003424:Crohn Disease / Q000517:prevention & control / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy; D007420:Intestine, Large / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D014945:Wound Healing
chemical_list: D001466:Barium Sulfate; D001379:Azathioprine