Differences in collagen metabolism between normal and osteoarthritic human articular cartilage.
Normal human articular cartilage synthesizes only one type of a chain, which exhibits the chromatographic behavior of the alpha(l)(II) chains described for chick and bovine cartilage. Osteoarthritic cartilage, on the other hand, synthesizes in addition a collagen containing alpha(2) chains and beta components. The different structural features of the two types of collagen may account for some of the functional defects of osteoarthritic cartilage.
D002358:Cartilage, Articular / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D002848:Chromatography, DEAE-Cellulose; D003094:Collagen / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D010003:Osteoarthritis / Q000378:metabolism*; D011392:Proline / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D003094:Collagen; D011392:Proline