title: Phytohaemagglutinin-induced lymphocyte transformation in patients before and after resection of large intestinal cancer.
abstract: Lymphocyte responses to stimulation with phytohaemagglutinin (PHA) have been compared in 20 patients with large intestinal cancer, 10 patients whose large intestinal cancers have been removed, and in 30 age- and sex-matched control individuals. Responses were markedly reduced in the tumour-bearing patients and were unaffected by substituting normal for autologous plasma during incubation. Responses, however, were normal after tumour resection suggesting that the defect in lymphocyte responsiveness is a reversible one and related to the presence of tumour tissue.
mesh_terms: D001005:Anus Neoplasms / Q000503:physiopathology; D003110:Colonic Neoplasms / Q000503:physiopathology; D006801:Humans; D007414:Intestinal Neoplasms / Q000276:immunology* / Q000601:surgery; D007420:Intestine, Large / Q000276:immunology; D037102:Lectins / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008875:Middle Aged; D013936:Thymidine / Q000378:metabolism
chemical_list: D037102:Lectins; D013936:Thymidine