title: Progesterone-dependent messenger RNA: heterospecific activity in vivo.
abstract: The action of progesterone in mediating the synthesis of avidin by the chick oviduct can be simulated by the intraoviductal instillation of nitrocellulose-trapped RNA from hormonally prepared chick or pigeon oviduct. Similarly, the pigeon oviduct synthesizes avidin in response to chick oviduct RNA. Thus, a heterospecific transfer of hormonal stimulation, through the transfer of progesterone-induced RNA, is demonstrated. The biological activity is lost after digestion by pancreatic ribonuclease. The 50-fold purification achieved by nitrocellulose chromatography of the total RNA preparation suggests that the activity resides in a messenger RNA fraction.
mesh_terms: D000818:Animals; D001360:Avidin / Q000096:biosynthesis; D002645:Chickens; D010856:Columbidae; D005260:Female; D010047:Ovalbumin / Q000096:biosynthesis*; D010057:Oviducts / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology* / Q000502:physiology; D014176:Protein Biosynthesis / Q000187:drug effects; D012333:RNA, Messenger / Q000096:biosynthesis / Q000494:pharmacology*; D013045:Species Specificity; D013268:Stimulation, Chemical
chemical_list: D012333:RNA, Messenger; D001360:Avidin; D011374:Progesterone; D010047:Ovalbumin