The fibrinolytic enzyme system in hypertension.
Fibrinogen, fibrinogen-related antigen (FR-antigen), and components of the fibrinolytic enzyme system were measured in patients with essential hypertension, renal disease with and without hypertension, and normal subjects. Essential hypertension was associated with a decrease in plasminogen activator and an increase in FR-antigen. In renal disease these changes were accompanied by increases in plasminogen activation inhibitor, alpha(2)-macroglobulin, alpha(1)-antitrypsin, and fibrinogen.
D000328:Adult; D000368:Aged; D000941:Antigens; D005340:Fibrinogen / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000209:etiology; D006977:Hypertension, Renal / Q000201:enzymology; D007674:Kidney Diseases / Q000201:enzymology; D008259:Macroglobulins / Q000378:metabolism*; D008875:Middle Aged; D010958:Plasminogen / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000378:metabolism*
D000941:Antigens; D008259:Macroglobulins; D014361:Trypsin Inhibitors; D005340:Fibrinogen; D010958:Plasminogen