Isotachysterol-3 and 25-hydroxyisotachysterol-3: analogs of 1,25-dihydrox vitamin D3.
Isotachysterol(3), 25-hydroxyisotachysterol(3), and isovitamin D(3) have been synthesized and tested for biological activity. Like 1,25-dihydroxyvitamin D(3), isotachysterol(3) stimulates intestinal calcium transport and bone calcium mobilization in anephric rats, whereas 25-hydroxyvitamin D(3) does not. Although isovitamin D(3) is biologically active in normal rats it is inactive in anephric rats.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000138:chemical synthesis / Q000494:pharmacology; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007421:Intestine, Small / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D009392:Nephrectomy; D051381:Rats; D012632:Secosteroids / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013261:Sterols / Q000138:chemical synthesis / Q000494:pharmacology*
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols; D012632:Secosteroids; D013261:Sterols; D002118:Calcium