title: Comparison of effects of six cholinomimetic drugs on inhibition of uptake of  3 H-( )-noradrenaline by guinea-pig atria.
abstract: The effects of N,N-dimethyl-N'-phenyl-piperazinium (DMPP), 4-(m-chlorophenyl-carbamoyloxy) - 2 - butynyltrimethylammonium chloride (McN-A-343), pilocarpine, acetylcholine, methacholi-ne and nicotine in inhibiting the uptake of (3)H-(+/-)-noradrenaline by guinea-pig atria were compared. In concentrations of 1 x 10(-4)M, the percentage inhibitions were as follows: DMPP, 89.1%; McN-A-343, 78.7%; pilocarpine 43.5%; acetylcholine, 35.7%; methacholine, 32.9%; nicotine, 21.6%.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003864:Depression, Chemical; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008688:Methacholine Compounds / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010277:Parasympathomimetics / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D014316:Tritium
chemical_list: D008688:Methacholine Compounds; D010277:Parasympathomimetics; D000644:Quaternary Ammonium Compounds; D010862:Pilocarpine; D014316:Tritium; D004246:Dimethylphenylpiperazinium Iodide; D009538:Nicotine; D000109:Acetylcholine; D009638:Norepinephrine