Kinetics of nortiptyline (NT) in rats in vivo and in the isolated perfused liver: demonstration of a 'first pass disappearance' of NT in the liver.
D000818:Animals; D002417:Cattle; D002849:Chromatography, Gas; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003903:Deuterium; D004912:Erythrocytes / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D013058:Mass Spectrometry; D009661:Nortriptyline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D003903:Deuterium; D009661:Nortriptyline