The effects of an anti-atherosclerotic drug, pyridinolcarbamate, on heart, vascular and brain biogenic amines.
The anti-atherosclerotic drug pyridinolcarbamate was investigated in the rat for its effects on heart, blood vessel and brain biogenic amines. The drug increased the concentration of noradrenaline in all tissues and of noradrenaline and 5-hydroxytryptamine in the brain. The possibility of a link between biogenic amines and atherosclerotic disease is discussed.
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D001679:Biogenic Amines / Q000378:metabolism*; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002219:Carbamates / Q000494:pharmacology*; D005260:Female; D005470:Fluorometry; D006321:Heart / Q000187:drug effects; D006632:Histamine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008638:Mesenteric Arteries / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D001679:Biogenic Amines; D002219:Carbamates; D008996:Monoamine Oxidase Inhibitors; D011725:Pyridines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006632:Histamine; D014364:Tryptophan; D009638:Norepinephrine