Action of oral metoclopramide on the gastrooesophageal junction in man.
The effect of oral metoclopramide, 10 mg, was studied with intraluminal manometry in 20 patients suffering from symptoms of gastrooesophageal reflux. The drug increased cardiac sphincter pressure and the amplitude of oesophageal peristaltic waves, but gastric motility was stimulated in only half of the patients. The clinical value of these pharmacological effects should be confirmed in therapeutic trials.
D000284:Administration, Oral; D000577:Amides / Q000494:pharmacology* / Q000627:therapeutic use; D001565:Benzoates / Q000494:pharmacology* / Q000627:therapeutic use; D004943:Esophagogastric Junction / Q000187:drug effects*; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects
D000577:Amides; D001565:Benzoates