title: On the molecular action of local anesthetics. 1. The mitochondrian as a model membrane system for studying local anesthetic action.
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006657:Histones / Q000008:administration & dosage / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008566:Membranes / Q000187:drug effects; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000187:drug effects*; D008933:Mitochondrial Swelling / Q000187:drug effects; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism; D011343:Procaine / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013997:Time Factors; D014634:Valinomycin / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D006657:Histones; D011506:Proteins; D014634:Valinomycin; D011343:Procaine; D011188:Potassium