Effect of glucagon on serum gastrin. II. Studies in pernicious anaemia and the Zollinger-Ellison syndrome.
Serum gastrin was measured by radioimmunoassay in four patients with pernicious anaemia and four patients with the Zollinger-Ellison syndrome before and after the intravenous injection of 1 mg glucagon. Serum gastrin fell significantly in the patients with pernicious anaemia whilst in the patients with the Zollinger-Ellison syndrome there was a significant rise. Concomitant measurement of gastric acid output in one subject with the Zollinger-Ellison syndrome also showed a rise in acid output with glucagon. The reason for the paradoxical rise in gastrin in response to glucagon in the Zollinger-Ellison syndrome is unknown, but the response may provide a further diagnostic aid to this condition.
D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000097:blood* / Q000175:diagnosis
D005755:Gastrins; D005934:Glucagon