Concentrations of asparagine in tissues of prepubertal rats after enzymic or dietary depletion of asparagine.
Growth of weanling rats was significantly depressed after 8 days of asparagine depletion produced by dietary means or by asparaginase treatment. Moreover, the concentration of free asparagine was significantly lowered in forebrain, skeletal muscle, liver, kidney, spleen and small intestines 3 h after an asparaginase injection, but remained lowered only in forebrain and skeletal muscle after 8 days of enzymic or dietary depletion of asparagine.
D000818:Animals; D001215:Asparaginase / Q000494:pharmacology; D001216:Asparagine / Q000378:metabolism* / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001835:Body Weight; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D001216:Asparagine; D001219:Aspartate Aminotransferases; D001215:Asparaginase