The distribution of lithium and its effects on the distribution and excretion of other ions in the rat.
1. In rats, lithium (ca 1 mEquiv/kg body weight) decreased brain sodium and magnesium, bone sodium and calcium and increased muscle calcium, plasma magnesium, urinary calcium and urine volume.2. Lithium was particularly concentrated in bone.
D000284:Administration, Oral; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002118:Calcium / Q000652:urine; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine; D005243:Feces / Q000032:analysis; D005260:Female; D005269:Femur / Q000032:analysis; D007274:Injections, Intraperitoneal; D008094:Lithium / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology* / Q000652:urine; D008274:Magnesium / Q000652:urine; D009132:Muscles / Q000032:analysis; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013054:Spectrophotometry, Atomic; D014508:Urea / Q000652:urine; D014882:Water-Electrolyte Balance / Q000187:drug effects
D010710:Phosphates; D014508:Urea; D008094:Lithium; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D011188:Potassium; D002118:Calcium