The synthesis of esters of bilirubin.
1-Alkyl-3-p-tolytriazenes were used to synthesize the methyl, ethyl, isopropyl and benzyl esters of bilirubin. Treatment of a chloroform solution of bilirubin with the triazene at room temperature gave high yields of the corresponding esters. These were identified by n.m.r. and mass spectroscopy together with elemental analysis. N.m.r. studies also suggest that bilirubin dimethyl ester is in the lactam rather than the lactim form.
D000433:1-Propanol; D000438:Alcohols / Q000138:chemical synthesis*; D001593:Benzyl Compounds; D001663:Bilirubin; D004952:Esters / Q000138:chemical synthesis; D000431:Ethanol; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol; D008722:Methods; D013696:Temperature
D000438:Alcohols; D001593:Benzyl Compounds; D004952:Esters; D000431:Ethanol; D000433:1-Propanol; D001663:Bilirubin; D000432:Methanol