Monoamine oxidase and aldehyde dehydrogenase activity in the striatum of rats after 6-hydroxydopamine lesion of the nigrostriatal pathway.
Monoamine oxidase and aldehyde dehydrogenase activity were significantly reduced in the striatum of rats 8 days after lesion of the nigrostriatal nerve pathway caused by 6-hydroxydopamine. Evidence is presented for the existence of an intraneuronal 'dopamine monoamine oxidase' and intraneuronal aldehyde dehydrogenase. Dopamine concentrations were reduced to 10% of their control values.
D000445:Aldehyde Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001479:Basal Ganglia / Q000201:enzymology*; D002247:Carbon Isotopes; D003342:Corpus Striatum / Q000201:enzymology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009410:Nerve Degeneration / Q000187:drug effects; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects
D002247:Carbon Isotopes; D006892:Hydroxydopamines; D000445:Aldehyde Oxidoreductases; D008995:Monoamine Oxidase; D004298:Dopamine