The synthesis of medium-chain fatty acids by lactating-rabbit mammary gland studied in vitro.
The proportion of C(8:0) and C(10:0) fatty acids synthesized by the microsomal plus particle-free supernatant fraction from lactating rabbit mammary gland is enhanced at high protein concentrations. This fraction appears to contain a soluble high-molecular-weight factor that modifies the specificity of the fatty acid synthetase complex for termination of the growing acyl chain.
D000818:Animals; D002247:Carbon Isotopes; D003600:Cytosol / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis*; D005260:Female; D066298:In Vitro Techniques; D007774:Lactation; D008321:Mammary Glands, Animal / Q000166:cytology / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D008970:Molecular Weight; D011247:Pregnancy; D011817:Rabbits; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000378:metabolism; D014462:Ultrafiltration
D002247:Carbon Isotopes; D005227:Fatty Acids; D064429:Fatty Acid Synthases