Inhibition by acetaldehyde of the pyruvate dehydrogenase complex from ox brain and ox kidney.
Low concentrations of acetaldehyde, similar to those that can occur in the brain of ethanol-treated animals, effectively inhibit the pyruvate dehydrogenase complex purified from ox brain or from ox kidney, although the precise mechanism of this inhibition remains to be defined.
D000079:Acetaldehyde / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002247:Carbon Isotopes; D002417:Cattle; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D011768:Pyruvate Dehydrogenase Complex / Q000037:antagonists & inhibitors; D013438:Sulfhydryl Compounds / Q000494:pharmacology
D000447:Aldehydes; D002247:Carbon Isotopes; D009097:Multienzyme Complexes; D011768:Pyruvate Dehydrogenase Complex; D013438:Sulfhydryl Compounds; D000079:Acetaldehyde