title: Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid.
abstract: The concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5-HIAA) were measured in five cases with partial or complete block of CSF circulation, at various levels. Determinations were made in both a lumbar and a cisternal, or `mixed', sample obtained during pneumoencephalography. Most of the HVA appears to enter the ventricular system at the lateral ventricles, whereas much of the 5-HIAA in CSF originates in lower neuronal structures, including the spinal cord. The spinal contribution to the 5-HIAA content of lumbar CSF is of the order of 23-37%.
mesh_terms: D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D002552:Cerebral Ventricles; D005911:Gliosis / Q000134:cerebrospinal fluid; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008161:Lumbosacral Region; D009362:Neoplasm Metastasis; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D011011:Pneumoencephalography; D013129:Spinal Puncture; D013595:Syringomyelia / Q000134:cerebrospinal fluid; D013904:Thoracic Vertebrae
chemical_list: D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid