Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride.
L-Azetidine-2-carboxylic acid (AZC), an analogue of proline, has been shown to partially ameliorate hepatic cirrhosis induced in rats by CCl(4). AZC caused a diminution in formation of collagen in the liver accompanied by a relative decrease in the pool of free proline. The synthesis of noncollagenous proteins in the livers of treated rats did not appear to be affected.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002247:Carbon Isotopes; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism; D006900:Hydroxylation; D006901:Hydroxylysine / Q000096:biosynthesis; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000032:analysis / Q000378:metabolism / Q000473:pathology; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D011392:Proline / Q000032:analysis / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000596:Amino Acids; D002247:Carbon Isotopes; D006901:Hydroxylysine; D003094:Collagen; D011392:Proline; D006909:Hydroxyproline