Infertility in female rabbits immunized with lactate dehydrogenase X.
Immunization of female rabbits with the sperm-specific lactate dehydrogenase (LDH-X) resulted in a highly significant reduction of pregnancies compared to nonimmunized controls. This is the first demonstration of immunosuppression of fertility by a crystalline protein shown to be strictly homogeneous by ultracentrifugation, polyacrylamide gel electrophoresis, immunodiffusion, and micro complement fixation.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D003267:Contraception; D003270:Contraceptive Agents; D005260:Female; D005306:Fertilization / Q000187:drug effects; D007114:Immunization; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits
D000906:Antibodies; D003270:Contraceptive Agents; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase