Chlorite-oxidized amylose as an adjuvant for interferon production.
Chlorite-oxidized amylose (COAM), when given intraperitoneally to mice and to cats, increased the titer of serum interferon subsequently induced by polyinosinic.polycytidylic acid (In.Cn). Increases ranged from 6- to 100-fold. Maximal effect was observed when COAM was given 3 h prior to In.Cn. COAM given intravenously prior to Newcastle disease virus also significantly increased serum interferon titers.
D000276:Adjuvants, Immunologic; D000818:Animals; D003562:Cytidine / Q000494:pharmacology; D006385:Hemagglutination Inhibition Tests; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007288:Inosine / Q000494:pharmacology; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D051379:Mice; D009522:Newcastle disease virus / Q000254:growth & development; D011134:Polysaccharides / Q000494:pharmacology*; D013400:Sugar Acids / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D011134:Polysaccharides; D013400:Sugar Acids; D007288:Inosine; D003562:Cytidine; D007372:Interferons