Growth retardation in young mice treated with d1-methadone.
Newborn mice injected daily for 6 weeks with dl-methadone in dosages of 2 to 8 milligrams per kilogram grew significantly more slowly than their saline-treated littermates. Litters given d-methadone, 4 milligrams per kilogram, grew normally. Concomitant treatment with naloxone, 10 milligrams per kilogram, prevented growth inhibition. A weight deficit persisted in mice observed 6 weeks after cessation of methadone treatment.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006128:Growth / Q000187:drug effects*; D007279:Injections, Subcutaneous; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009270:Naloxone / Q000494:pharmacology
D009270:Naloxone; D008691:Methadone