Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma.
Antibody distinct from that involved in neutralization and directed to an antigen (AG-4) induced in HEp-2 cells by infection with herpesvirus type 2 was identified in serums from patients with cervical carcinoma by means of a quantitative micro complement fixation test. The presence of antibody to AG-4 correlates well with the extent of the tumor; antibody is virtually absent in matched control women and in women with therapy and without recurrent neoplasia. Reactivity is not observed with control antigen consisting of a cell extract prepared from uninfected HEp-2 cells. The possible prognostic significance of this antibody and its implications are discussed.
D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000914:Antibodies, Viral / Q000032:analysis*; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D003168:Complement Fixation Tests; D005260:Female; D006564:Herpesviridae / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D009500:Neutralization Tests; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000382:microbiology*
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D000951:Antigens, Neoplasm; D000956:Antigens, Viral