A double isotope technique for the evaluation of drug action on gastric evacuation and small bowel propulsion studied in the rat.
A method to measure simultaneously gastric evacuation and small bowel propulsion in the rat is presented. The value of the method in testing drug action is described. The effect of an antidiarrhoeal agent, diphenoxylate, was analysed and it was shown that it retarded small bowel propulsion without influencing gastric evacuation.
D000818:Animals; D004386:Duodenum / Q000502:physiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000502:physiology; D007456:Iodine Isotopes; D007540:Isonipecotic Acids / Q000494:pharmacology*; D008297:Male; D008722:Methods; D011205:Povidone; D051381:Rats; D013270:Stomach / Q000502:physiology; D013501:Surface-Active Agents / Q000494:pharmacology
D007456:Iodine Isotopes; D007540:Isonipecotic Acids; D013501:Surface-Active Agents; D011205:Povidone