title: Prostaglandin involvement in hypothalamic control of gonadotropin and prolactin release.
abstract: Prostaglandin E(2) (PGE(2)) injected into the third ventricle of ovariectomized rats increased plasma luteinizing hormone dramatically and follicle stimulating hormone slightly. PGE(1) elevated prolactin; PGF(1alpha) or PGF(2alpha) had no effect. PGE(2) or PGE(1) injected directly into the anterior pituitary were ineffective. These results suggest that specific prostaglandins act at the hypothalamus to control pituitary hormone release.
mesh_terms: D000818:Animals; D002369:Castration; D002552:Cerebral Ventricles; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007031:Hypothalamus / Q000502:physiology*; D007267:Injections; D007986:Luteinizing Hormone / Q000097:blood*; D010902:Pituitary Gland; D011388:Prolactin / Q000097:blood*; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D011863:Radioimmunoassay; D051381:Rats
chemical_list: D011453:Prostaglandins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone