title: Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.
abstract: Neurofibrillary degeneration is an important pathological finding in senile and presenile dementia of the Alzheimer type. Experimentally, aluminum induces neurofibrillary degeneration in neurons of higher mammals. Aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease.
mesh_terms: D000535:Aluminum / Q000032:analysis* / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000378:metabolism / Q000473:pathology; D001923:Brain Chemistry; D001927:Brain Diseases / Q000139:chemically induced; D002415:Cats; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000032:analysis / Q000378:metabolism; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008526:Medulla Oblongata / Q000032:analysis; D009900:Optic Nerve / Q000032:analysis; D013116:Spinal Cord / Q000378:metabolism; D013788:Thalamus / Q000032:analysis
chemical_list: D000535:Aluminum