The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart.
1. Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea-pig isolated heart.2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002127:Calcium Isotopes; D004347:Drug Interactions; D005110:Extracellular Space; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000032:analysis / Q000378:metabolism; D010042:Ouabain / Q000494:pharmacology*; D010477:Perfusion; D010672:Phenytoin / Q000378:metabolism / Q000494:pharmacology*; D011188:Potassium / Q000032:analysis / Q000494:pharmacology*; D012964:Sodium / Q000032:analysis; D012975:Sodium Isotopes; D013997:Time Factors; D014316:Tritium
D000889:Anti-Arrhythmia Agents; D002127:Calcium Isotopes; D012975:Sodium Isotopes; D014316:Tritium; D010042:Ouabain; D010672:Phenytoin; D012964:Sodium; D011188:Potassium; D002118:Calcium