Bile acids and vitamin A absorption in man: the effects of two bile acid-binding agents, cholestyramine and lignin.
In 14 healthy volunteers, the addition of 12 g cholestyramine to a vitamin A-containing test meal reduced the expected rise in serum vitamin A by 59.5% (p<0.001). By contrast, lignin had no significant effect in 12 subjects. This study confirms the importance of bile acids in vitamin A absorption and the ineffectiveness of lignin as a sequestrator of conjugated bile acids.
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000494:pharmacology*; D005215:Fasting; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008031:Lignin / Q000494:pharmacology*; D008297:Male; D013997:Time Factors; D014801:Vitamin A / Q000097:blood / Q000378:metabolism*
D001647:Bile Acids and Salts; D002792:Cholestyramine Resin; D014801:Vitamin A; D008031:Lignin