Effect of intravenous prostaglandin E 2  on platelet function, coagulation, and fibrinolysis.
Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PGE(2), a change which was not noted by the glass-bead column technique. The administration of PGE(2) caused more rapid platelet disaggregation following ADP-induced aggregation but had no effect on the platelet count, collagen-induced aggregation, or platelet factor 3 activity. An increase in plasma antithrombin concentration and euglobulin lysis activity was also noted. These results support the concept that prostaglandin E(2) might have a role in the prevention of thrombosis.
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000991:Antithrombins; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D010973:Platelet Adhesiveness / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012712:Serum Globulins; D013925:Thromboplastin; D013927:Thrombosis / Q000517:prevention & control
D000991:Antithrombins; D011453:Prostaglandins; D012712:Serum Globulins; D003094:Collagen; D013925:Thromboplastin