Experience with a commercial preparation of 125I-labelled human albumin for study of albumin metabolism.
Evaluation of a commercial preparation of (125)I-labelled albumin for use in the study of albumin metabolism is described. In eight subjects with normal albumin metabolism the proportion of the dose of radioiodide excreted was stable throughout a period of 17 days, indicating that there was no excessive denaturation of the iodinated albumin. Characteristics of albumin metabolism-pool sizes, catabolic rate, etc-were in agreement with currently accepted normal values. It is concluded that this preparation of iodinated albumin is suitable for metabolic use.
D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria; D005260:Female; D006801:Humans; D007456:Iodine Isotopes / Q000652:urine; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume; D011489:Protein Denaturation; D012709:Serum Albumin / Q000032:analysis; D012711:Serum Albumin, Radio-Iodinated
D000418:Albumins; D007456:Iodine Isotopes; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated