title: Perfluorocarbons having a short dwell time in the liver.
abstract: Perfluorinated organic liquids are useful as high capacity oxygen and carbon dioxide solvents. After intravenous infusion most of these perfluorinated emulsions are deposited in the liver and spleen in a matter of days, where they remain for the lifetime of the animal. Hence, while they may be useful as isolated organ perfusion media their value as artificial blood is limited. A family of perfluorocarbons has now been discovered, which, although deposited in the liver after circulation in the blood, leave the liver to be excreted via the lungs and skin in a matter of days without apparent harmn to the animal.
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D005465:Fluorocarbon Polymers / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism*; D051379:Mice; D012119:Respiration; D012867:Skin / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
chemical_list: D005465:Fluorocarbon Polymers