The effect of desensitization to adenosine triphosphate on the peristaltic reflex in guinea-pig ileum.
Contractions of the longitudinal muscle of guinea-pig ileum were inhibited by adenosine triphosphate. This inhibition was prevented by specific desensitization of the tissue to adenosine triphosphate whilst the peristaltic reflex was unaffected. The results suggest that the transmitter substance released from the intramural inhibitory neurones activated during peristalsis is not adenosine triphosphate.
D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003888:Desensitization, Immunologic; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006168:Guinea Pigs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects
D006584:Hexamethonium Compounds; D000255:Adenosine Triphosphate; D000109:Acetylcholine; D009638:Norepinephrine