Effect of orally administered prostaglandin E 2  and its 15-methyl analogues on gastric secretion.
The effect of orally administered prostaglandin E(2) and its synthetic 15-methyl analogues on gastric secretion in man was studied. The parent E(2) compound did not inhibit basal secretion, whereas both the 15 (S) 15-methyl-E(2) methyl ester and its isomer, 15 (R) 15-methyl-E(2) methyl ester inhibited basal acid secretion. This action is likely to be a direct one on the parietal cell, and it could prove of value in the treatment of peptic ulcer.
D000284:Administration, Oral; D003864:Depression, Chemical; D004952:Esters / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000188:drug therapy; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*
D004952:Esters; D011453:Prostaglandins