Drug-induced blood dyscrasias in Sweden.
Cases of drug-induced aplastic anaemia, haemolytic anaemia, thrombocytopenia, and agranulocytosis reported to the Swedish Adverse Drug Reaction Committee during the five-year period 1966-70 have been analysed and compared with cases of the same cytopenias from "all" causes. Oral diuretics were a dominant cause of drug-induced thrombocytopenia, methyldopa of haemolytic anaemia, and oxyphenbutazone of aplastic anaemia. Computer systems should help such studies, particularly in showing a changing pattern of complications and causes.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000453:epidemiology; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000453:epidemiology; D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003201:Computers; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008750:Methyldopa / Q000009:adverse effects; D008875:Middle Aged; D010113:Oxyphenbutazone / Q000009:adverse effects; D012737:Sex Factors; D013548:Sweden; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000453:epidemiology
D004232:Diuretics; D008750:Methyldopa; D010113:Oxyphenbutazone