Heart muscle viability following hypoxia: protective effect of acidosis.
The mechanical performance of hypoxic heart muscle is further depressed by an acid pH. In contrast to preparations at normal or alkaline pH. however, hypoxic preparations at acid pH do not develop contracture and exhibit full recovery of mechanical activity upon reoxygenation.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology / Q000503:physiopathology*; D000471:Alkalosis / Q000503:physiopathology; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology; D004558:Electric Stimulation; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D007511:Ischemia / Q000150:complications; D009119:Muscle Contraction; D009584:Nitrogen / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D051381:Rats
D002245:Carbon Dioxide; D009584:Nitrogen; D010100:Oxygen