Relative DNA damage induced in cultured human skin fibroblasts by exposure to the precarcinogen 2-acetylaminofluorene, the proximate carcinogen N-hydroxy-2-acetylaminofluorene, and the ultimate carcinogen N-acetoxy-2-acetylaminofluorene.
D000081:Acetamides / Q000494:pharmacology; D000328:Adult; D000438:Alcohols / Q000494:pharmacology; D001706:Biopsy; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D003090:Coliphages; D003497:Cyclic N-Oxides / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004279:DNA, Viral; D004171:Diploidy; D005069:Evaluation Studies as Topic; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005449:Fluorenes / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006877:Hydroxamic Acids / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology; D009690:Nucleic Acid Conformation; D011804:Quinolines / Q000494:pharmacology; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium
D000081:Acetamides; D000438:Alcohols; D002273:Carcinogens; D003497:Cyclic N-Oxides; D004279:DNA, Viral; D005449:Fluorenes; D006877:Hydroxamic Acids; D009574:Nitro Compounds; D011804:Quinolines; D014316:Tritium; D004247:DNA