Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.
The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.
D000090:Acetoacetates / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001921:Brain / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development; D003066:Coenzyme A Ligases / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D005260:Female; D005333:Fetus; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D008954:Models, Biological; D011247:Pregnancy; D051381:Rats
D000090:Acetoacetates; D008055:Lipids; D003066:Coenzyme A Ligases