Glucose metabolism in the rat small intestine: the effect of glucose analogues on hexokinase activity.
The effect of intubation of starved rats with solutions of glucose, 3-O-methylglucose, mannose, 2-deoxyglucose and sorbitol on the subcellular location of hexokinase in the mucosa of the small intestine was studied. Glucose, 3-O-methylglucose and mannose caused the soluble hexokinase activity to rise to a value similar to that found in fed animals, whereas sorbitol and 2-deoxyglucose caused smaller increases.
D000818:Animals; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006593:Hexokinase / Q000378:metabolism*; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D007441:Intubation, Gastrointestinal; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008358:Mannose / Q000494:pharmacology; D008738:Methyl Ethers / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D013012:Sorbitol / Q000494:pharmacology; D013347:Subcellular Fractions / Q000201:enzymology; D013997:Time Factors
D008738:Methyl Ethers; D013012:Sorbitol; D007770:L-Lactate Dehydrogenase; D006593:Hexokinase; D005947:Glucose; D008358:Mannose