title: Complement-induced platelet protein alterations.
abstract: Polypeptides of high molecular weight are deleted from the sedimentable fraction of platelets subjected, while intact, to complement action. These polypeptides, distinct from the previously described thrombin-sensitive protein of this fraction, also diminish after platelets are exposed to thrombin. They may be of importance in the molecular events underlying complement-triggered changes in platelet function.
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000032:analysis / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis*; D003165:Complement System Proteins / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology
chemical_list: D001798:Blood Proteins; D010455:Peptides; D003165:Complement System Proteins; D013917:Thrombin