title: Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.
abstract: The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000506:poisoning; D000284:Administration, Oral; D002606:Charcoal / Q000494:pharmacology / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D002792:Cholestyramine Resin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D009336:Necrosis / Q000139:chemically induced; D011041:Poisoning / Q000188:drug therapy; D013997:Time Factors
chemical_list: D002792:Cholestyramine Resin; D002606:Charcoal; D000082:Acetaminophen