Abnormal bone mineral maturation in the chronic uremic state.
X-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.
D000818:Animals; D001031:Apatites; D001846:Bone Development; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D005260:Female; D006834:Hydrazines; D008722:Methods; D008903:Minerals / Q000032:analysis / Q000378:metabolism*; D009392:Nephrectomy; D051381:Rats; D013977:Tibia / Q000254:growth & development / Q000378:metabolism; D014511:Uremia / Q000378:metabolism*; D014961:X-Ray Diffraction
D001031:Apatites; D006834:Hydrazines; D008903:Minerals; D003094:Collagen