Amenorrhoea after discontinuing combined oestrogen-progestogen oral contraceptives.
Out of 210 women seen at the Middlesex Hospital with secondary amenorrhoea the 63 who developed it after stopping oral contraceptives were fully investigated. Five had organic disease sufficient to account for the amenorrhoea (one had severe diabetes, one a pituitary tumour, and three premature ovarian failure); two patients had galactorrhoea (one of whom also had the pituitary tumour); two had anorexia nervosa.Of the 63 women 40 (63%) had suffered from amenorrhoea or prolonged or irregular menstrual cycles before taking the pill, and this suggested that combined oestrogen-progestogen oral contraceptives should be used with caution for women with irregular menstruation.Nineteen patients wished to become pregnant and 12 have so far done so after treatment with clomiphene or gonadotrophins.In another study 204 women recorded when their first menstrual cycle occurred after stopping the pill. Seventy-four had a cycle longer than five weeks but only five exceeded three months, and only one of the five had more than six months' amenorrhoea. These results confirm that the incidence of amenorrhoea after stopping oral contraceptives is low.
D000328:Adult; D000342:Affective Symptoms / Q000150:complications; D000568:Amenorrhea / Q000139:chemically induced* / Q000209:etiology; D002996:Clomiphene / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000009:adverse effects*; D048909:Diabetes Complications; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D008596:Menotropins / Q000627:therapeutic use; D008598:Menstruation; D010049:Ovarian Diseases / Q000150:complications; D010911:Pituitary Neoplasms / Q000150:complications; D011372:Progestins / Q000009:adverse effects; D011446:Prospective Studies; D013997:Time Factors
D003276:Contraceptives, Oral; D004967:Estrogens; D011372:Progestins; D002996:Clomiphene; D008596:Menotropins