title: Neural disturbances in chickens caused by dietary T-2 toxin.
abstract: Graded concentrations of dietary T-2 toxin (0, 1, 2, 4, 8, and 16 mug/g) were fed to groups of 40 chickens. T-2 toxin was found to cause an abnormal positioning of the wings, hysteroid seizures, and impaired righting reflex in young chickens. The abnormal wing positioning occurred spontaneously or as the result of dropping from a height of 1 meter. The seizures could be elicited by rough handling or loud noises. The seizures and the abnormal wing posture would not occur again when the stimulus was repeated unless a rest period of 3 to 6 h was allowed. The loss of righting reflex could be demonstrated at any time. The total incidence of neural symptoms was dependent on the length of exposure to T-2 toxin and to its concentration. Neural toxicity occurred at dosages of 4, 8, and 16 mug per g of diet, which are the same doses that retard growth. This neural toxicity of T-2 toxin in chickens is similar to the neural disturbances associated with alimentary toxic aleukia, a nutritional toxicosis of humans produced by eating moldy grain. T-2 toxin has been implicated also in moldy corn toxicosis which has neural manifestations in horses and swine.
mesh_terms: D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D001584:Benzoxepins; D002490:Central Nervous System / Q000187:drug effects*; D002645:Chickens; D004032:Diet; D005670:Fusarium; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D009183:Mycotoxins; D009461:Neurologic Manifestations; D004856:Postural Balance / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D012640:Seizures / Q000139:chemically induced; D013141:Spiro Compounds; D014921:Wings, Animal; D003313:Zea mays
chemical_list: D001584:Benzoxepins; D009183:Mycotoxins; D013141:Spiro Compounds