title: Blood coagulation changes during mid-trimester abortion induced by prostaglandin F2 alpha.
abstract: Serial studies on the coagulation system were made during second-trimester abortion induced by extra-amniotic, intra-amniotic, vaginal, and intravenous prostaglandin F(2)alpha. No significant changes were found in the prothrombin time, partial thromboplastin time, or levels of fibrin-fibrinogen degradation products. An increase in the activity of factor X occurred with all routes of administration; the activity of factor VIII increased during extra-amniotic, vaginal, and intravenous administration; factor V activity increased during extra-amniotic and vaginal administration; and the activity of factor VII-X complex increased slightly at the time of abortion with all methods.The findings suggest that though prostaglandin induction of second-trimester abortion produces changes in the coagulation system the effects are much less than those which accompany induction of abortion by hypertonic saline or abdominal delivery in late pregnancy.
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000650:Amnion; D001777:Blood Coagulation / Q000187:drug effects*; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D011247:Pregnancy; D011453:Prostaglandins / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D011517:Prothrombin Time; D013997:Time Factors; D014621:Vagina
chemical_list: D011453:Prostaglandins; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005170:Factor X; D005337:Fibrin; D005340:Fibrinogen