title: Inheritance and influence of histocompatibility (HL-A) antigens in adult coeliac disease.
abstract: In a study of histocompatibility antigens in adult coeliac disease the HL-A phenotypes have been determined in 117 patients and 149 of their first-degree relatives, of whom 94 had had a jejunal biopsy performed. There was an increased frequency of the HL-A 8 antigen in the patients and their relatives. Family studies showed no irregularity in the inheritance of both this antigen and the HL-A 1 and 8 haplotype.
mesh_terms: D001706:Biopsy; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology; D005260:Female; D005838:Genotype; D006649:Histocompatibility Antigens; D006801:Humans; D007125:Immunogenetics; D007583:Jejunum / Q000276:immunology; D008297:Male; D010375:Pedigree; D010641:Phenotype
chemical_list: D006649:Histocompatibility Antigens