Linoleic acid hydroperoxide: impaired bacterial uptake by alveolar macrophages, a mechanism of  oxidant lung injury.
Exogenous linoleic acid hydroperoxide causes in vitro impairment of both bacterial uptake and the phagocytic stimulation of (14)CO(2) production from [1-(14)C]glucose in rabbit alveolar macrophages by an undefined effect on the cell membrane. This effect may be one mechanism for the defective pulmonary bacterial clearance characteristic of oxidant lung injury.
D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D002250:Carbon Radioisotopes; D003864:Depression, Chemical; D005947:Glucose / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D008041:Linoleic Acids / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010545:Peroxides / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D010734:Phosphogluconate Dehydrogenase / Q000037:antagonists & inhibitors; D011817:Rabbits; D013210:Staphylococcus
D002250:Carbon Radioisotopes; D008041:Linoleic Acids; D010545:Peroxides; D002245:Carbon Dioxide; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D005947:Glucose