Aberration of porphyrin metabolism in iron-deficient anaemic rats.
Iron-deficient rats excreted greater amounts of 5-aminolaevulinate in urine but the output of porphobilinogen was decreased considerably. In addition, activity of the enzyme 5-aminolaevulinate dehydratase was diminished in bone marrow and liver. The results suggest that in iron deficiency a defect occurs in porphyrin synthesis at the level of porphobilinogen formation.
D000747:Anemia, Hypochromic / Q000378:metabolism*; D000818:Animals; D001853:Bone Marrow / Q000201:enzymology; D007982:Levulinic Acids / Q000652:urine; D008099:Liver / Q000201:enzymology; D008297:Male; D011162:Porphobilinogen / Q000652:urine; D000623:Porphobilinogen Synthase / Q000378:metabolism; D011166:Porphyrins / Q000378:metabolism*; D051381:Rats
D007982:Levulinic Acids; D011166:Porphyrins; D011162:Porphobilinogen; D000623:Porphobilinogen Synthase