Myositis in father and daughter.
The occurrence of myositis in a father and his daughter is reported. The daughter's illness resembled childhood dermatomyositis and progressed to systemic involvement and death less than four years from the onset of symptoms. In the case of the father the illness followed the course of adult polymyositis and there was little evidence of systemic involvement. The immunological and genetic significance of the two cases is discussed.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009132:Muscles / Q000473:pathology; D009220:Myositis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011651:Pulmonary Artery / Q000473:pathology
D011239:Prednisolone; D000410:Alanine Transaminase; D003402:Creatine Kinase; D001379:Azathioprine; D008727:Methotrexate