title: Cyclical combination chemotherapy in advanced breast cancer.
abstract: Results with cyclical combination chemotherapy in advanced breast cancer are presented. The overall remission rate, 79 per cent, is superior to that obtained by two conventional endocrine procedures, administration of norethisterone acetate and hypophysectomy. The advantage is especially pronounced in patients with visceral deposits.
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000628:therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D009640:Norethindrone / Q000008:administration & dosage / Q000627:therapeutic use; D012075:Remission, Spontaneous; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D009640:Norethindrone; D005472:Fluorouracil; D008727:Methotrexate