Thyroid hormone action: a cell-culture system responsive to physiological concentrations of thyroid hormones.
Cells from a rat pituitary tumor cell line will respond in vitro to physiological concentrations of L-thyroxine and L-triiodothyronine. The cells are grown in a cultutre medium that contains serum from a hypothyroid calf. Dose-response relationships of a vacriety of thyronine derivatives indicate that this system has a specificity of response which is similar to that observed in vitro.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism*; D010911:Pituitary Neoplasms; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D005947:Glucose; D013974:Thyroxine