Trauma of the erythrocyte membrane associated with low shear stress.
Studies have been performed on erythrocytes that have been subjected to a low shear stress of less than 100 dyn/cm(2) in a cone-and-plate viscometer. Alterations that were observed included decreased red cell survival, increased osmotic fragility, changes in the cation permeability of the red cell membrane, and a reduction in membrane-associated acetylcholinesterase activity. Some of these alterations are similar to those accompanying aging. The observed data suggest that one segment of the erythrocyte population is more susceptible to shear-induced damage than the rest of the cells.
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002860:Chromium Radioisotopes; D004285:Dogs; D004912:Erythrocytes / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D009996:Osmotic Fragility; D012964:Sodium / Q000378:metabolism; D013053:Spectrophotometry; D013314:Stress, Mechanical; D013997:Time Factors; D014783:Viscosity
D002860:Chromium Radioisotopes; D012964:Sodium; D000110:Acetylcholinesterase