Transmission on an active electrical response between fibroblasts (L cells) in cell culture.
An active electrical response, the hyperpolarizing activation or H.A. response, is characteristic of L cells (a continuous line of fibroblasts) and is transmitted in a decremental manner between contiguous cells. Direct electrical coupling between pairs of L cells occurs occasionally, but transmission of the active electrical response is not dependent on such electrical connections. Some L cells are sensitive to acetylcholine but the transmitted response is not dependent on a cholinergic mechanism. 5-Iodosalicylate blocks the active electrical response. The response can be elicited readily by mechanical stimuli, and thus can serve both as a mechanical and chemical receptor mechanism and as a means of communication between cells.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004553:Electric Conductivity / Q000187:drug effects; D004558:Electric Stimulation; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D007739:L Cells / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology
D012459:Salicylates; D010672:Phenytoin; D008274:Magnesium; D000109:Acetylcholine; D011188:Potassium