Studies with some novel uricosuric agents and their metabolites: correlation between clinical activity and drug-induced displacement of urate from its albumin-binding sites.
D000328:Adult; D000368:Aged; D001577:Benzophenones / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D001667:Binding, Competitive; D003404:Creatinine / Q000652:urine; D003619:Dansyl Compounds; D005461:Fluorine / Q000494:pharmacology / Q000627:therapeutic use; D006073:Gout / Q000188:drug therapy; D006218:Halofenate / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011688:Purinones / Q000652:urine; D012709:Serum Albumin / Q000378:metabolism*; D013432:Sulfathiazoles / Q000494:pharmacology / Q000627:therapeutic use; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use; D014527:Uric Acid / Q000097:blood* / Q000652:urine; D014528:Uricosuric Agents / Q000494:pharmacology / Q000627:therapeutic use*
D001577:Benzophenones; D003619:Dansyl Compounds; D011688:Purinones; D012709:Serum Albumin; D013432:Sulfathiazoles; D013449:Sulfonamides; D014528:Uricosuric Agents; D014527:Uric Acid; D005461:Fluorine; D003404:Creatinine; D006218:Halofenate