Mammary carcinoma: enzymatic block in disialoganglioside biosynthesis.
The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM(1) accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis.
D000818:Animals; D001551:Benz(a)Anthracenes; D002518:Ceramides / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005260:Female; D005732:Gangliosides / Q000032:analysis / Q000096:biosynthesis*; D005964:Glucosyltransferases / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D009438:Neuraminic Acids; D051381:Rats; D014166:Transferases / Q000378:metabolism*
D001551:Benz(a)Anthracenes; D002518:Ceramides; D005732:Gangliosides; D009438:Neuraminic Acids; D014166:Transferases; D005964:Glucosyltransferases