Isolation and characterization of a pituitary peptidase specifically releasing, from growth hormone, a peptide (somantin) with antagonistic activity to insulin in vitro.
D000818:Animals; D002498:Centrifugation; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D013006:Growth Hormone / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007329:Insulin Antagonists; D008722:Methods; D008970:Molecular Weight; D010447:Peptide Hydrolases / Q000302:isolation & purification*; D010455:Peptides / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D010902:Pituitary Gland / Q000201:enzymology*; D012756:Sheep; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D007329:Insulin Antagonists; D010455:Peptides; D013006:Growth Hormone; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010447:Peptide Hydrolases