Effect on neonatal jaundice of oestrogens and progestogens taken before and after conception.
Study of 182 newborn babies has shown that among bottle-fed infants the mean plasma bilirubin concentration was slightly but significantly higher (P <0.01) in those whose mothers had previously used steroid contraceptives. A similar finding was not noted among breast-fed infants.A further 16 infants whose mothers had received progestogen therapy during their pregnancy had a mean plasma bilirubin concentration which was significantly higher than each of the four other groups of infants studied (P <0.01). Icterus occasionally reached clinically important levels in these babies.
D000033:Abortion, Threatened / Q000517:prevention & control; D001663:Bilirubin / Q000097:blood; D001942:Breast Feeding; D003276:Contraceptives, Oral / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000009:adverse effects / Q000627:therapeutic use; D006932:Hyperbilirubinemia / Q000139:chemically induced; D007225:Infant Food; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000139:chemically induced*; D008297:Male; D011247:Pregnancy; D011372:Progestins / Q000009:adverse effects*; D013997:Time Factors
D003276:Contraceptives, Oral; D004967:Estrogens; D006908:Hydroxyprogesterones; D011372:Progestins; D001663:Bilirubin