Role of coxsackievirus B4 in the pathogenesis of acute glomerulonephritis.
Coxsackievirus B(4) was isolated from the throat, nose, blood, stools and urine of a 9-year-old boy with acute glomerulonephritis and a pneumonitis. Neutralization test showed a greater than fourfold rise in the antibody titre to coxsackievirus B(4). The antistreptolysin O titre was elevated, but the complement component was within the normal range. The importance of the coxsackievirus B(4) in the pathogenesis of acute glomerulonephritis is clearly indicated; however, further investigations are needed to understand the details of the virus-kidney interaction.
D000208:Acute Disease; D000989:Antistreptolysin / Q000032:analysis; D001769:Blood / Q000382:microbiology; D002648:Child; D003165:Complement System Proteins / Q000032:analysis; D003384:Coxsackievirus Infections; D004770:Enterovirus / Q000276:immunology / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology; D005921:Glomerulonephritis / Q000150:complications / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D009666:Nose / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D011014:Pneumonia / Q000150:complications; D013290:Streptococcal Infections / Q000150:complications; D014556:Urine / Q000382:microbiology
D000989:Antistreptolysin; D003165:Complement System Proteins