Regulation of muscle acetylcholine sensitivity by muscle activity in cell culture.
Muscle in tissue culture provides a good system for studying longterm changes in surface membrane acetylcholine sensitivity. Muscle fibers stimulated intermittently over prolonged periods are less sensitive to iontophoretically applied acetylcholine and bind less (125)I-labeled alpha-bungarotoxin than inactive fibers.
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism; D002478:Cells, Cultured; D002642:Chick Embryo; D004558:Electric Stimulation; D007456:Iodine Isotopes; D007478:Iontophoresis; D009119:Muscle Contraction; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology
D002038:Bungarotoxins; D007456:Iodine Isotopes; D013779:Tetrodotoxin; D000109:Acetylcholine