Histone acetylation and hormone action. Early effects of aldosterone on histone acetylation in rat kidney.
Histone acetylation in the kidney of the adrenalectomized rat was increased 5 min after a physiological dose of aldosterone. The increase was exclusively in the histone F2a1. The increase in histone acetylation was given by 9alpha-fluorocortisol, deoxycorticosterone and cortisol, but not by progesterone. The increase in histone acetylation was abolished by prior treatment of the animals with the anti-mineralocorticoid agent, SC14266 [potassium 3-(3-oxo-17beta-hydroxy-4,6-androstadien-17-yl) propionate]; the basal degree of histone acetylation was unaffected. Pretreatment of the animals with actinomycin D or cyclo-heximide did not affect the stimulation, showing the stimulation was not due to increased synthesis of enzyme.
D000085:Acetates / Q000378:metabolism; D000107:Acetylation; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003900:Desoxycorticosterone / Q000494:pharmacology; D005260:Female; D005438:Fludrocortisone / Q000494:pharmacology; D006657:Histones / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D014316:Tritium
D000085:Acetates; D006657:Histones; D014316:Tritium; D003609:Dactinomycin; D003900:Desoxycorticosterone; D000450:Aldosterone; D011374:Progesterone; D003513:Cycloheximide; D005438:Fludrocortisone; D006854:Hydrocortisone