Prostaglandin 15 (R) 15-methyl-E2 methyl ester for suppression of gastric acidity in gravida at term.
During the second hour after giving 100 mug of orally administered prostaglandin 15 (R) 15-methyl-E(2) methyl ester in the pregnant patient at term a noticeable reduction in basal gastric acid secretion took place. At this dose no excessive uterine stimulation was observed. Prostaglandin 15 (R) 15-methyl-E(2) methyl ester could prove of value in the preoperative preparation of the pregnant patient before anaesthesia for reducing the incidence of acid regurgitation.
D004952:Esters; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D001239:Inhalation; D007743:Labor, Obstetric / Q000187:drug effects; D010120:Oxytocics; D011229:Preanesthetic Medication; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D011300:Preoperative Care; D011453:Prostaglandins / Q000008:administration & dosage; D012636:Secretory Rate / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D004952:Esters; D010120:Oxytocics; D011453:Prostaglandins