Specific monovalent cation effects on modification of reovirus infectivity by chymotrypsin digestion in vitro.
Specific monovalent cations control the modification of reovirus infectivity by chymotrypsin. Digestion in K(+), Rb(+), or Cs(+) reduces infectivity several logs, whereas in Na(+) or Li(+) digestion markedly enhances infectivity.
D000818:Animals; D002586:Cesium / Q000494:pharmacology*; D002918:Chymotrypsin / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D007739:L Cells; D008094:Lithium / Q000494:pharmacology*; D051379:Mice; D011188:Potassium / Q000494:pharmacology*; D012087:Reoviridae / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development / Q000472:pathogenicity*; D012413:Rubidium / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology*
D002586:Cesium; D008094:Lithium; D012964:Sodium; D012321:DNA-Directed RNA Polymerases; D002918:Chymotrypsin; D012413:Rubidium; D011188:Potassium