Skeletal muscle resting membrane potential in potassium deficiency.
The resting transmembrane potential of skeletal muscle (E(m)) is thought to be a function of the ratio of intracellular to extracellular potassium concentration ([K(i)]/[K(o)]). In potassium deficiency, the fall of [K(i)] is proportionately less than the fall of [K(o)], thus theoretically predicting a rise of E(m). To examine this theory and to characterize E(m) in kaliopenic myopathy, muscle composition and E(m) were measured during moderate (n = 5) and severe (n = 11) K deficiency in the dog and compared with measurements in the severely K-deficient rat (n = 10). Mean measured E(m) rose during moderate K deficiency in four of five dogs (-85.4 to -94.6 mV) and during severe K deficiency in the rat (-89.1 to -94.9 mV). Both values closely approximated the increase in E(m) predicted by the Goldman equation. In contrast, during severe K deficiency in the dog, a significant decline (P < 0.001) of mean E(m) to -55 mV was observed.Since skeletal myopathy and paralysis do not occur in the rat as a consequence of K deficiency, the observation that E(m) falls as paralysis occurs in the unexercised dog suggests that alteration of muscle membrane function may play a role in kaliopenic myopathy. Such an event could explain the ease with which frank muscle necrosis may be induced by exercise in the K-deficient dog.
D000136:Acid-Base Equilibrium; D000818:Animals; D001706:Biopsy; D002712:Chlorides / Q000032:analysis; D004285:Dogs; D004576:Electromyography; D008564:Membrane Potentials; D009119:Muscle Contraction; D009132:Muscles / Q000032:analysis / Q000503:physiopathology*; D009135:Muscular Diseases / Q000503:physiopathology; D011188:Potassium / Q000032:analysis; D011191:Potassium Deficiency / Q000503:physiopathology*; D051381:Rats; D012964:Sodium / Q000032:analysis; D014867:Water / Q000032:analysis
D002712:Chlorides; D014867:Water; D012964:Sodium; D011188:Potassium