title: The substrate analog, bromopyruvate, as a bridging agent for the active site of 2-keto-3-deoxy-6-phosphogluconic aldolase. Chemical evidence for a carboxylate adjacent to the Schiff's base-forming lysine.
mesh_terms: D000446:Aldehyde-Lyases / Q000037:antagonists & inhibitors*; D000478:Alkylation; D000588:Amines / Q000032:analysis; D000596:Amino Acids / Q000032:analysis; D001665:Binding Sites; D001894:Borohydrides; D001966:Bromine; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D003545:Cysteine; D004355:Drug Stability; D005942:Gluconates; D008239:Lysine; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D011485:Protein Binding; D011487:Protein Conformation; D011549:Pseudomonas / Q000201:enzymology; D011773:Pyruvates; D012545:Schiff Bases; D012965:Sodium Chloride; D013329:Structure-Activity Relationship; D013462:Sulfur Radioisotopes; D014316:Tritium
chemical_list: D000588:Amines; D000596:Amino Acids; D001894:Borohydrides; D002250:Carbon Radioisotopes; D005942:Gluconates; D011773:Pyruvates; D012545:Schiff Bases; D013462:Sulfur Radioisotopes; D014316:Tritium; D012965:Sodium Chloride; D000446:Aldehyde-Lyases; D008239:Lysine; D003545:Cysteine; D001966:Bromine