Renal response to acid load after phenformin.
Normally the kidneys respond to an acid load by increased ammonia production. In six patients with adult-type diabetes this response was reduced by a mean 50% after a therapeutic dose of phenformin. The reduced ability to compensate for acid loads may be one factor leading to metabolic acidosis and lactoacidosis sometimes associated with phenformin therapy.
D000328:Adult; D000368:Aged; D000643:Ammonium Chloride / Q000378:metabolism*; D003864:Depression, Chemical; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008875:Middle Aged; D010629:Phenformin / Q000494:pharmacology* / Q000627:therapeutic use; D000644:Quaternary Ammonium Compounds / Q000652:urine
D000644:Quaternary Ammonium Compounds; D000643:Ammonium Chloride; D010629:Phenformin