Irreversible enzyme inhibitors. 198. Diaminodihydro-S-triazines and diaminopyrimidines bearing substituted (ureidomethyl)phenyl substituents as reversible inhibitors of dihydrofolate reductase.
D000818:Animals; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005493:Folic Acid Antagonists; D007939:Leukemia L1210 / Q000201:enzymology; D008722:Methods; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014508:Urea / Q000138:chemical synthesis / Q000494:pharmacology
D002219:Carbamates; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D014227:Triazines; D014508:Urea