Comparative studies on the chemical stability and therapeutic effectiveness of water-insoluble 5-(3,3-bis(2-chloroethyl)-1-triazeno)imidazole-4-carboxamide (NSC-82196) and its water-soluble hydrochloride against L1210 mouse leukemia.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004355:Drug Stability; D006207:Half-Life; D006851:Hydrochloric Acid / Q000627:therapeutic use; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D012492:Salts / Q000627:therapeutic use; D012995:Solubility; D012996:Solutions; D013535:Suspensions; D014226:Triazenes / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity
D000970:Antineoplastic Agents; D007093:Imidazoles; D009588:Nitrogen Mustard Compounds; D012492:Salts; D012996:Solutions; D013535:Suspensions; D014226:Triazenes; D006851:Hydrochloric Acid