Oxygen affinity and electrolyte distribution of human blood: changes induced by propranolol.
Propranolol causes a massive leakage of potassium ions from red cells, which results in an alteration of the Gibbs-Donnan equilibrium across the red cell membrane. According to such a mechanism, the presence of propranolol significantly increases the hydrogen ion activity of the interior of the red cell, causing a decreased oxygen affinity of hemoglobin according to the classical Bohr effect. No release of 2,3-diphosphoglycerate which may be bound to the membrane is thus necessary to explain the effect of propranolol on the oxygen dissociation curve of blood.
D004163:Diphosphoglyceric Acids / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood*; D011188:Potassium / Q000097:blood; D011433:Propranolol / Q000494:pharmacology*; D012964:Sodium / Q000097:blood
D004163:Diphosphoglyceric Acids; D012964:Sodium; D011433:Propranolol; D011188:Potassium; D010100:Oxygen