title: Biochemical aspects of motor neurone disease--Madras pattern.
abstract: A detailed study of four cases of MND-Madras has shown a significantly low plasma citrate level in these subjects. Comparison with other related groups of neurological disorders indicates the citrate/pyruvate ratio to be of diagnostic value in MND-Madras. This seems to suggest that the pathophysiology of MND-Madras may centre round altered citrate metabolism.
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000681:Amylases / Q000097:blood; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002951:Citrates / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D009132:Muscles / Q000473:pathology; D009468:Neuromuscular Diseases / Q000097:blood*; D011773:Pyruvates / Q000097:blood* / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002951:Citrates; D011773:Pyruvates; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000681:Amylases; D005947:Glucose