title: Biosynthetic precursors of vitamin K as growth promoters for Bacteroides melaninogenicus.
abstract: The growth of a vitamin K-requiring strain of Bacteroides melaninogenicus was promoted by some postulated and proven biosynthetic precursors of bacterial menaquinones, 1,4-dihydroxy-2-naphthoic acid, shikimic acid, chorismic acid, and 4(2'-carboxyphenyl)-4-oxobutyric acid. Growth of the organism with [2',4-(14)C(2)]-4(2'-carboxy phenyl)-4-oxobutyric acid as the vitamin K replacement gave rise to a mixture of radioactive menaquinone-9 and menaquinone-10; the dilution factor for this incorporation was 1.8.
mesh_terms: D001439:Bacteroides / Q000187:drug effects / Q000254:growth & development*; D002087:Butyrates / Q000494:pharmacology; D009281:Naphthalenes / Q000494:pharmacology; D011809:Quinones / Q000494:pharmacology; D012765:Shikimic Acid / Q000494:pharmacology; D013997:Time Factors; D014451:Ubiquinone / Q000494:pharmacology; D014812:Vitamin K / Q000494:pharmacology*
chemical_list: D002087:Butyrates; D009281:Naphthalenes; D011809:Quinones; D014812:Vitamin K; D014451:Ubiquinone; D012765:Shikimic Acid