title: Tobramycin in bronchial secretions.
abstract: The penetration of tobramycin sulfate (nebramycin factor 6) into normal lower respiratory tract secretions was studied in a dog model. After a 1.7 mg/kg intravenous dose of tobramycin, the antibiotic was detected promptly in bronchial secretions, but the peak bronchial secretion concentration was not usually reached until 2 h after injection (mean level 1.15 mug/ml). The maximum tobramycin concentration in bronchial fluids was equal to the mean inhibitory concentrations that have been reported for about 80% of Pseudomonas isolates.
mesh_terms: D000617:Aminoglycosides / Q000032:analysis / Q000097:blood; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000097:blood; D001980:Bronchi / Q000378:metabolism*; D004285:Dogs; D007275:Injections, Intravenous; D008954:Models, Biological; D013997:Time Factors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents