Comparative blood levels and metabolism of INH and an INH-matrix preparation in fast and slow inactivators.
Two groups of tuberculosis patients, phenotyped as either slow or fast inactivators of isoniazid, participated in a preliminary bioavailability study of a new INH-matrix preparation with sustained action. The absorption, excretion and metabolic patterns of the new form were compared with those of standard INH tablets in both sets of patients, using a crossover technique.The INH-matrix was more slowly absorbed by both slow and fast inctivators. When the latter were treated with 30 mg./kg. of the matrix formulation the blood levels attained were comparable with those observed in slow acetylators treated with 10 mg./kg. normal INH. Although this dose is three times that normally recommended with standard INH, blood levels remained within safe limits owing to the drug's slow release from the matrix.
D000085:Acetates / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D000293:Adolescent; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D008297:Male; D010641:Phenotype; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy*
D000085:Acetates; D003692:Delayed-Action Preparations; D007538:Isoniazid