In vitro and in vivo activity of penicillinase inhibitor KA-107 against Staphylococcus aureus FS-1277.
The activities of penicillinase inhibitor, KA-107 extracted from culture filtrates of Streptomyces gedanensis ATCC 4880, were studied by using penicillin-resistant S. aureus FS-1277 and by means of in vitro and in vivo tests.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003470:Culture Media; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010405:Penicillinase / Q000378:metabolism; D013203:Staphylococcal Infections / Q000517:prevention & control; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D013302:Streptomyces / Q000378:metabolism; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D003470:Culture Media; D065093:beta-Lactamase Inhibitors; D010405:Penicillinase