T-2 toxin as an emetic factor in moldy corn.
Extracts of Fusarium poae (NRRL 3287) grown either on sterile corn at 8 C or in Richards solution at room temperature were shown to have emetic activity in pigeons at nonlethal concentration under conditions of oral and intravenous administration. The causative agent was found to be T-2 toxin (3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxy-Delta(9)-trichothecene). Oral and intravenous mean toxic dose values for this compound were found to be 0.72 and 0.15 mg/kg, respectively, as compared with an oral mean lethal dose of 2.75 mg/kg. The fact that T-2 toxin causes emesis at nonlethal concentrations may explain, at least in part, the observance of vomiting as a symptom resulting from ingestion of cereal grains infected with toxic Fusarium species containing T-2 or a similar toxin.
D000284:Administration, Oral; D000818:Animals; D002855:Chromatography, Thin Layer; D010856:Columbidae; D003470:Culture Media; D004639:Emetics / Q000494:pharmacology*; D005506:Food Contamination; D005670:Fusarium / Q000378:metabolism; D007275:Injections, Intravenous; D009183:Mycotoxins / Q000494:pharmacology*; D003313:Zea mays
D003470:Culture Media; D004639:Emetics; D009183:Mycotoxins