Inhibition of phosphatidylcholine synthesis in mammary tissue by 2-chloroethyltrimethylammonium chloride.
The incorporation of choline into phosphatidylcholine in mammary tissue from lactating cows is impeded by 2-chloroethyltrimethylammonium chloride at concentrations ranging from 0.3 to 9mm. This compound is a non-competitive inhibitor of choline kinase (K(m) 0.25mm), having K(i) 17mm. It is suggested that 2-chloroethyltrimethylammonium chloride may inhibit choline entry into the tissue.
D000818:Animals; D002417:Cattle; D005260:Female; D008321:Mammary Glands, Animal / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000096:biosynthesis*
D010713:Phosphatidylcholines