A transplantable mouse lymphoma with unusual azurophilic granules.
A transplantable malignant lymphoma arising spontaneously in the C3H/Jax Heston mouse line is described. Such a spontaneously arising lymphoma within this strain has not been previously reported. The tumor exhibits 100% transmission in the C3H/HeJax mouse line and has been successfully carried through 113 transfers. No spontaneous regression was observed in 678 animals. The tumor terminates in lymphocytic leukemia after 2 to 3 weeks. The neoplastic cells contain azurophilic granules which stain purple-red with Wright's or tetrachrome blood stains, are not metachromatic with toluidine blue, are not peroxidase positive and show a pleomorphic structure at the level of electron microscopy. While the nature and function of azurophilic granules remains undetermined, their presence in this transmissible tumor offers a better opportunity to study them.
D000818:Animals; D001202:Ascitic Fluid; D001853:Bone Marrow / Q000473:pathology; D002467:Cell Nucleus; D004396:Coloring Agents; D003594:Cytoplasmic Granules; D006056:Golgi Apparatus; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006338:Heart Neoplasms / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000473:pathology; D013249:Sternum / Q000473:pathology; D013899:Thoracic Neoplasms / Q000473:pathology; D014184:Transplantation, Homologous
D004396:Coloring Agents