Autoimmune hemolytic anemia terminating seven years later in Hodgkin's disease.
A 64-year-old woman was treated during 7(1/2) years for an isolated AIHA by transfusions, prednisone and splenectomy. The autoantibody was a warm-type IgG with anti-e specificity. At autopsy, generalized Hodgkin's disease of mixed cellularity was found. Only 11 similar cases of hemolytic anemia preceding the development of Hodgkin's disease have been reported in the literature. This association suggests a possible underlying defect in the immune system of the host.
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology; D003298:Coombs Test; D005260:Female; D006689:Hodgkin Disease / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012008:Recurrence; D013156:Splenectomy
D001323:Autoantibodies; D007074:Immunoglobulin G; D011241:Prednisone