Evolution of bone disease over 10 years in 135 patients with terminal renal failure.
An objective radiographic study of erosions, fractures, and periarticular and vascular calcification was made in a series of 135 patients over 10 years of maintenance haemodialysis therapy. The four lesions progressed at different rates, consistent with variation in the response of tissues to a changing biochemical milieu and deficiency in vitamin D metabolites. The half time for development of individual radiographic signs was 3.4 years for vascular calcification, 9 years for fractures, 16 years for periarticular calcification, and 22.9 years for erosions. Calcification of the dorsalis pedis artery seen as a developing ring or tube was an early and valuable sign of disturbed calcium metabolism. In these patients renal osteodystrophy is a chronic condition with a prolonged time course.
D000293:Adolescent; D000328:Adult; D001158:Arteries; D002114:Calcinosis / Q000000981:diagnostic imaging; D002118:Calcium / Q000032:analysis; D002136:Calcium, Dietary; D002648:Child; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000000981:diagnostic imaging*; D005260:Female; D050723:Fractures, Bone / Q000000981:diagnostic imaging; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000000981:diagnostic imaging; D010710:Phosphates / Q000097:blood; D011859:Radiography; D006435:Renal Dialysis; D012272:Ribs / Q000293:injuries; D013997:Time Factors; D014652:Vascular Diseases / Q000000981:diagnostic imaging; D014807:Vitamin D / Q000378:metabolism
D002136:Calcium, Dietary; D010710:Phosphates; D014807:Vitamin D; D002118:Calcium