Retinyl acetate: effect on cellular content of RNA in epidermis in cell culture in chemically defined medium.
Cell cultures of epidermis from newborn mice were established in chemically defined medium. Additions of retinyl acetate to these cultures caused a significant increase in cellular RNA content. Addition of insulin and hydrocortisone to the cultures potentiated the effect of retinyl acetate on cellular RNA content.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004357:Drug Synergism; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism*; D014801:Vitamin A / Q000494:pharmacology*
D007328:Insulin; D014801:Vitamin A; D012313:RNA; D004247:DNA; D006854:Hydrocortisone