Lack of effect of chronic nicotine administration on fatty acid distribution in the liver, testis, and adipose tissue of male Fischer-344 rats.
A comparison is made of the percentage compositions of major fatty acids in liver and testis phospholipids, liver and abdominal adipose tissue triglycerides, and liver sterol esters in male Fischer-344 rats administered a physiological saline control or a "smoking" dose of nicotine (1000 micro g base/kg/day, subcutaneously) for 2 or 22 months. Results indicate that there is no major trend, or significant difference, between nicotine- or saline-treated rats with respect to major fatty acid distribution. Some differences in fatty acid distribution in the various lipid fractions were found between young and old rats.
D000273:Adipose Tissue / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D002784:Cholesterol / Q000032:analysis; D002855:Chromatography, Thin Layer; D004952:Esters; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005989:Glycerides / Q000032:analysis; D007279:Injections, Subcutaneous; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D013737:Testis / Q000032:analysis / Q000378:metabolism*; D014280:Triglycerides / Q000032:analysis
D004952:Esters; D005227:Fatty Acids; D005989:Glycerides; D010743:Phospholipids; D014280:Triglycerides; D009538:Nicotine; D002784:Cholesterol