Decreased antinociceptive activity of morphine in rats pretreated intraventricularly with 5,6-dihydroxytryptamine, a long-lasting selective depletor of brain serotonin.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002552:Cerebral Ventricles; D007267:Injections; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009411:Nerve Endings / Q000187:drug effects*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects*; D011984:Sensory Receptor Cells / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D014363:Tryptamines / Q000008:administration & dosage / Q000494:pharmacology*
D014363:Tryptamines; D012701:Serotonin; D009020:Morphine