Alteration of bile salt metabolism by dietary fibre (bran).
Feeding dietary fibre in the form of bran induced changes in bile salt metabolism in five people with intact gall bladders. There was evidence of reduced dehydroxylation of bile salts; the proportion of deoxycholate conjugates in bile was reduced and the transfer of radioactivity from labelled taurocholate to deoxycholate was decreased. These findings, which were independent of changes in intestinal transit rate, imply that bran reduced the degradation of bile salts by colonic bacteria. This property of bran accords with recent theories that fibre-depleted diets favour the degradation of bile salts in the colon. These findings may be relevant to the aetiology of large bowel cancer.
D001419:Bacteria / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002763:Cholecystectomy; D002793:Cholic Acids / Q000378:metabolism; D003106:Colon / Q000382:microbiology; D003840:Deoxycholic Acid / Q000378:metabolism; D004032:Diet; D004386:Duodenum / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000502:physiology; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D013656:Taurocholic Acid / Q000378:metabolism; D014908:Triticum
D001647:Bile Acids and Salts; D002250:Carbon Radioisotopes; D002793:Cholic Acids; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013656:Taurocholic Acid