title: Influence of histones on the antibody response in guinea pigs to vaccination with A-Aichi-2-68 (H3 N2) influenza virus.
abstract: The influence of total, F1, and F3 histones on the primary antibody response in guinea pigs to vaccination with influenza virus A/2/Aichi/2/68 (H3 N2) was investigated. It was found that histones can greatly reduce the immunoglobulin (Ig) M and, to a smaller degree, the IgG antibody response. The immunosuppressive effect of histones was found to depend critically on the dose of virus used for vaccination, on the type and dose of histones, and on the schedule of histone application.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005019:Ethyl Ethers; D006168:Guinea Pigs; D006657:Histones / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007165:Immunosuppression Therapy; D007252:Influenza Vaccines; D008623:Mercaptoethanol; D009975:Orthomyxoviridae / Q000276:immunology; D010783:Photometry; D014611:Vaccination
chemical_list: D005019:Ethyl Ethers; D006657:Histones; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007252:Influenza Vaccines; D008623:Mercaptoethanol