Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.
Protein and ribonucleic acid (RNA) syntheses increase in the liver during Q fever, coincident with progressive increments in cortisol levels. Cell-free protein-synthesizing systems indicate that the pH 5 enzyme fraction was chiefly responsible for enhanced activity. Although the polysome profiles from normal and infected livers were similar, the number of liver ribosomes doubled during infection. There was a concomitant increase in orotate incorporation in the 28s, 18s, and 4s RNA species of infected liver.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002474:Cell-Free System; D003381:Coxiella / Q000276:immunology; D004247:DNA / Q000378:metabolism; D004589:Electrophoresis, Disc; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver; D011132:Polyribosomes; D014176:Protein Biosynthesis; D011778:Q Fever / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis* / Q000378:metabolism; D014316:Tritium
D000596:Amino Acids; D014316:Tritium; D012313:RNA; D004247:DNA; D006854:Hydrocortisone