Inhibition of Mycoplasma pneumoniae by actinomycin D.
Growth of Mycoplasma pneumoniae was completely prevented by 0.06 mug of actinomycin D/ml, and 0.00375 mug/ml caused 90% inhibition. It thus appears that M. pneumoniae is more susceptible to actinomycin D than previously reported. Low concentrations (0.019 mug/ml) of the antibiotic primarily inhibited ribonucleic acid synthesis and high concentrations (20 mug/ml) inhibited both ribonucleic and deoxyribonucleic acid synthesis.
D002470:Cell Survival / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis; D003609:Dactinomycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D004269:DNA, Bacterial; D012329:RNA, Bacterial; D014316:Tritium; D003609:Dactinomycin; D013936:Thymidine; D014529:Uridine