Chloroform toxicity in mice: correlation of renal and hepatic necrosis with covalent binding of metabolites to tissue macromolecules.
D000818:Animals; D001665:Binding Sites; D002250:Carbon Radioisotopes; D002725:Chloroform / Q000378:metabolism / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009336:Necrosis / Q000378:metabolism / Q000473:pathology*; D009928:Organ Specificity; D010634:Phenobarbital / Q000494:pharmacology; D010882:Piperonyl Butoxide / Q000494:pharmacology; D012737:Sex Factors
D002250:Carbon Radioisotopes; D002725:Chloroform; D003577:Cytochrome P-450 Enzyme System; D010882:Piperonyl Butoxide; D010634:Phenobarbital