Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.
Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.
D000483:Alleles; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D012883:Skin Ulcer / Q000139:chemically induced* / Q000235:genetics
D001551:Benz(a)Anthracenes; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases