Effects of quazodine (MJ 1988) on contractions of the isolated hemidiaphragm of the rat and the biventer cervicis muscle of the chick.
1. The effects of quazodine and theophylline have been studied on the rat hemidiaphragm and chick biventer cervicis preparations in vitro.2. Theophylline and quazodine enhanced maximal twitches and contractural responses to acetylcholine and carbachol.3. These actions on contractility were exerted directly upon the muscle fibres and were dependent upon the concentration of calcium ions in the bathing solution.4. In addition, quazodine enhanced the neuromuscular blocking activity of tubocurarine, probably by a prejunctional action.5. Theophylline potentiated acetylcholine to a greater extent than it potentiated carbachol thus suggesting that theophylline possesses anticholinesterase activity.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002645:Chickens; D003964:Diaphragm / Q000187:drug effects; D004357:Drug Synergism; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008738:Methyl Ethers / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D014403:Tubocurarine / Q000494:pharmacology
D008738:Methyl Ethers; D011799:Quinazolines; D002217:Carbachol; D013806:Theophylline; D000109:Acetylcholine; D002118:Calcium; D014403:Tubocurarine