Tobramycin and gentamicin concentrations in the serum of normal and anephric patients.
The serum half-life of tobramycin was found to be the same as that of gentamicin in patients with similar renal function. The values ranged from 2 hr in normal volunteers to 53.4 hr in anephric patients. Both drugs were readily removed from the serum by the Kiil artificial kidney, with a 70% reduction in serum concentrations during a 12-hr dialysis period.
D000617:Aminoglycosides / Q000097:blood*; D000900:Anti-Bacterial Agents / Q000097:blood*; D005839:Gentamicins / Q000097:blood*; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000097:blood; D009392:Nephrectomy
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins