Hyperactivity and brain catecholamines in lead-exposed developing rats.
Newborn rats that suckled mothers eating a diet containing 4 percent lead carbonate display hyperactivity, aggressiveness, and excessive stereotyped behavior starting at 4 weeks of age. There is an eightfold increase in the concentration of lead in brain, no change in norepinephrine, but a 20 percent decrease in dopamine relative to coetaneous controls. This suggests a relationship between central nervous system dysfunction due to lead and dopamine metabolism in brain.
D000374:Aggression / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D001942:Breast Feeding; D002395:Catecholamines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006120:Grooming; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced*; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013239:Stereotyped Behavior
D002395:Catecholamines; D007854:Lead; D004298:Dopamine; D009638:Norepinephrine