Effects of a morphine-rabbit anti-morphine antibody mixture on guinea-pig isolated ileum.
Incubates of morphine with serum globulins obtained from sera of rabbits immunized with a morphine-bovine serum albumin conjugate produced immediate Schultz-Dale contractions when added to superfused, electrically stimulated guinea-pig ileal strips. Incubates of morphine with Krebs-Henseleit solution produced relaxation and depression of tone, and inhibition of electrically induced contractions. It is concluded that the spasm of guinea-pig ileum produced by incubates containing morphine-binding serum globulins and morphine resulted from transient passive sensitization and an acute anaphylactic type of response.
D000818:Animals; D000906:Antibodies; D001666:Binding Sites, Antibody; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects*; D066298:In Vitro Techniques; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D012712:Serum Globulins / Q000494:pharmacology
D000906:Antibodies; D012712:Serum Globulins; D009020:Morphine