title: U-42, 126, a new antimetabolite antibiotic: production, biological activity, and taxonomy of the producing microorganism.
abstract: A new antimetabolite antibiotic, U-42,126, was discovered by use of a specific in vitro screen. U-42,126 was produced by the fermentation of Streptomyces sviceus. Its antimicrobial activity in vitro was limited to fungi. Certain bacteria were inhibited only when cultivated in completely synthetic media. U-42,126 was active in vivo against L1210 leukemia in mice.
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000935:Antifungal Agents / Q000378:metabolism / Q000494:pharmacology*; D000963:Antimetabolites / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002854:Chromatography, Paper; D005998:Glycine / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000494:pharmacology*; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
chemical_list: D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000963:Antimetabolites; D010080:Oxazoles; D005998:Glycine