Effect of hepatic insufficiency on 5-fluorocytosine concentrations in serum.
Hepatic function failed to influence serum concentrations of the antifungal agent 5-fluorocytosine when the drug was given intravenously to rabbits with CCl(4)-induced hepatic insufficiency or orally to a patient with postnecrotic cirrhosis.
D000818:Animals; D000935:Antifungal Agents / Q000097:blood*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood; D003596:Cytosine / Q000097:blood*; D005437:Flucytosine / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D011817:Rabbits; D013997:Time Factors
D000935:Antifungal Agents; D003596:Cytosine; D005437:Flucytosine