title: Fatty acyl-coenzyme A elongation in brain of normal and quaking mice.
abstract: Microsomal enzyme systems from mouse brain that catalyze, respectively, the elongation of palmitoyl-coenzyme A (palmitoyl-CoA), stearoyl-CoA, or arachidyl-CoA appear and reach maximal activity at different times after birth of the animal. A specific C(20)-CoA elongating system exists in mouse brain in addition to the previously recognized C(16)-CoA and C(l8)-CoA elongating enzymes. The C(20)-CoA elongation system is severely reduced in the mutant quaking mouse.
mesh_terms: D000367:Age Factors; D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis; D001921:Brain / Q000201:enzymology*; D002250:Carbon Radioisotopes; D003065:Coenzyme A; D003711:Demyelinating Diseases / Q000201:enzymology / Q000235:genetics / Q000662:veterinary*; D064429:Fatty Acid Synthases / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D010169:Palmitic Acids / Q000096:biosynthesis; D012376:Rodent Diseases / Q000201:enzymology* / Q000235:genetics; D013229:Stearic Acids / Q000096:biosynthesis
chemical_list: D001095:Arachidonic Acids; D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D013229:Stearic Acids; D064429:Fatty Acid Synthases; D003065:Coenzyme A