Correlation of the cardiac sensitizing potential of halogenated hydrocarbons with their physicochemical properties.
The cardiac sensitizing potencies of a range of 14 halogenated hydrocarbons were assessed in conscious dogs by comparing the partial pressures (Pcs) needed to sensitize the heart to adrenaline. These were found to be directly related to their saturated vapour pressures (Ps) and the ratio Pcs/Ps was approximately constant although the values of partial pressures differed nearly 700-fold. It is suggested that cardiac sensitization is probably a structurally non-specific action and may be regarded as another example of physical toxicity.
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D055598:Chemical Phenomena; D002621:Chemistry; D004285:Dogs; D004357:Drug Synergism; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006846:Hydrocarbons, Halogenated / Q000008:administration & dosage / Q000494:pharmacology*; D008970:Molecular Weight; D055585:Physical Phenomena; D010825:Physics; D014693:Ventricular Fibrillation / Q000139:chemically induced
D000777:Anesthetics; D006846:Hydrocarbons, Halogenated; D004837:Epinephrine