Species differences in the metabolism of norephedrine in man, rabbit and rat.
1. (+/-)-2-Amino-1-phenyl[1-(14)C]propan-1-ol ([(14)C]norephedrine) was administered orally to man, rat and rabbit and the metabolites excreted in the urine were identified and measured. Pronounced species differences in the metabolism of the drug were found. 2. Three male human subjects, receiving 25mg each of [(14)C]norephedrine hydrochloride, excreted over 90% of the (14)C in the first day. The main metabolite was the unchanged drug (86% of the dose) and minor metabolites were hippuric acid and 4-hydroxynorephedrine. 3. In rats given 12mg of the drug/kg almost 80% of the (14)C administered was excreted in the first day. The major metabolites in the urine were the unchanged drug (48% of the dose), 4-hydroxynorephedrine (28%) and trace amounts of side-chain degradation products. 4. Rabbits given 12mg of the drug/kg excreted 85-95% of the dose of (14)C in the urine in the first 24h after dosing. The major metabolites in the urine were conjugates of 1,2-dihydroxy-1-phenylpropane (31% of the dose) and of 1-hydroxy-1-phenylpropan-2-one (27%) and hippuric acid (20%). The unchanged drug was excreted in relatively small amounts (8%).
D000818:Animals; D002250:Carbon Radioisotopes; D002845:Chromatography; D002849:Chromatography, Gas; D002854:Chromatography, Paper; D005260:Female; D006626:Hippurates / Q000378:metabolism; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D010665:Phenylpropanolamine / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013045:Species Specificity
D002250:Carbon Radioisotopes; D006626:Hippurates; D010665:Phenylpropanolamine