Enhancement of interferon production in mouse cell line, a high-yielding source of mouse interferon.
Priming with interferon prior to poly(I).poly(C) treatment of a mouse cell line, MO 57/2, followed by sequential administration of metabolic inhibitors, resulted in the production of high yields of mouse interferon.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D003513:Cycloheximide / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D008809:Mice, Inbred C3H; D011070:Poly I-C / Q000494:pharmacology
D003911:Dextrans; D003609:Dactinomycin; D007372:Interferons; D003513:Cycloheximide; D011070:Poly I-C