Predictions of the antimalarial activity of arylamidinoureas.
1. Regression equations were calculated relating the observed antimalarial potencies of arylamidinoureas to their predicted physicochemical properties.2. A two-parameter equation was used to forecast the antimalarial activity of more arylamidinoureas.3. Thirteen compounds of the predicted type were synthesized, and their observed antimalarial potencies compared with the forecasts.
D000284:Administration, Oral; D000578:Amidines / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004195:Disease Models, Animal; D051379:Mice; D008954:Models, Biological; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D010961:Plasmodium; D012044:Regression Analysis; D013329:Structure-Activity Relationship
D000578:Amidines; D000962:Antimalarials; D010671:Phenylurea Compounds