title: (2-(3-Nitrotyrosine))oxytocin, a wealky activity analogue of the hormone bound by neurophysin.
abstract: An analogue of oxytocin containing a nitro group ortho to the phenolic hydroxyl group of the tyrosyl residue was prepared by nitration of the hormone with tetranitromethane. [2-(3-Nitro-l-tyrosine)]oxytocin was bound by neurophysin although its pharmacological activity was virtually abolished. The oxytocic activity of the analogue on the isolated rat uterus was 1.1i.u./mg.
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D002845:Chromatography; D002850:Chromatography, Gel; D008697:Methane; D009481:Neurophysins; D009574:Nitro Compounds; D010121:Oxytocin; D013053:Spectrophotometry; D014443:Tyrosine
chemical_list: D009481:Neurophysins; D009574:Nitro Compounds; D014443:Tyrosine; D010121:Oxytocin; D008697:Methane