Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol.
Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Delta(1)-tetrahydrocannabinol ([(3)H]-Delta(1)-THC; 2 mg/kg i.v.) but not to the effect of [(3)H]-Delta(1)-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Delta(1)-THC or its metabolites. It was concluded that changes in metabolism or distribution of Delta(1)-THC are not responsible for tolerance at least to the hypothermic effect of Delta(1)-THC in mice.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002188:Cannabis / Q000378:metabolism*; D003864:Depression, Chemical; D013759:Dronabinol / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D013696:Temperature; D014316:Tritium
D014316:Tritium; D013759:Dronabinol