Possible modulating influence of frontal cortex on nigro-striatal function.
1. After administration of (+)-amphetamine, rats with unilateral ablations of the frontal cortex rotated either ipsilaterally or contralaterally as a function of time after surgery.2. At early postoperative intervals (1-7 days), rotation was towards the side of the lesion.3. At later times (15-30 days), rotation was towards the intact side.4. Repeated testing with amphetamine appeared to slow the time-course of changes in rotational behaviour.5. These results suggest that a dopaminergic nigro-striatal system is modulated by the frontal cortex and that unilateral removal of the latter produces a denervation supersensitivity of the former.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry; D002628:Chemoreceptor Cells / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000293:injuries / Q000502:physiology*; D051381:Rats; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D003913:Dextroamphetamine; D004298:Dopamine