Blood changes in experimental arthritis in two types of genetically different rats.
1. Rats genetically resistant to dextran and other agents producing the anaphylactoid reaction (NR rats), have a higher polymorph count than do rats which react to these agents (R rats).2. NR rats do not develop polyarthritis when a hind paw is injected intradermally with Freund's adjuvant.3. The polyarthritis produced by an intravenous injection of Mycoplasma arthritidis culture develops more slowly in NR rats than in R rats.4. It is not clear whether the higher polymorph count in NR rats is a main factor in determining their resistance to adjuvant-induced arthritis.
D000818:Animals; D001168:Arthritis / Q000097:blood*; D003165:Complement System Proteins / Q000032:analysis; D003911:Dextrans; D004342:Drug Hypersensitivity; D005620:Freund's Adjuvant; D006400:Hematocrit; D006736:Horses; D007958:Leukocyte Count; D008297:Male; D009113:Muramidase / Q000097:blood; D009174:Mycoplasma; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology*
D003911:Dextrans; D003165:Complement System Proteins; D005620:Freund's Adjuvant; D009113:Muramidase