Cytologic changes in dogs lungs induced by chronic exposure to ozone.
Beagle dogs exposed for 8 hours a day to 3 ppm O(3) for 18 months showed cytologic changes that indicate metabolic alterations. The endoplasmic reticulum of the type 2 alveolar epithelial cells in the proximal alveoli were frequently dilated and contained a moderately electron-dense substance having a periodicity of approximately 754 A. This condition was accompanied by a substantial reduction in the lamellar membranes in the characteristic lamellar bodies of the type 2 cells, suggesting a sequestering of protein in the endoplasmic reticulum. In addition, endothelial cells contained paracrystalline arrays of cytoplasmic membranes not observed in control animals.
D000818:Animals; D002462:Cell Membrane; D004285:Dogs; D004721:Endoplasmic Reticulum; D004847:Epithelial Cells; D005260:Female; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008854:Microscopy, Electron; D010126:Ozone / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000473:pathology
D010126:Ozone