Microbial production of tenuazonic acid analogues.
The fungus Alternaria tenuis normally produces tenuazonic acid (3-acetyl-5-secbutyltetramic acid). On supplementation of the culture substrate with l-valine and l-leucine, the organism formed two new tetramic acids, 3-acetyl-5-isopropyltetramic acid and 3-acetyl-5-isobutyltetramic acid, respectively. l-Phenylalanine was not utilized by the organism as a tetramic acid precursor.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D007930:Leucine / Q000378:metabolism; D003904:Mitosporic Fungi / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D011760:Pyrrolidinones / Q000096:biosynthesis*; D014633:Valine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; D010649:Phenylalanine; D007930:Leucine; D014633:Valine