Methotrexate in liver and bile after intravenous dosage in man.
Measurements of methotrexate have been made in the liver and plasma of 4 patients and in the bile and plasma of 1 patient receiving [(3)H]methotrexate. Projections from a theoretical model of concentration of methotrexate in liver are confirmed but projections of biliary excretion are not.
D000328:Adult; D001646:Bile / Q000032:analysis*; D006801:Humans; D007275:Injections, Intravenous; D008099:Liver / Q000032:analysis*; D008113:Liver Neoplasms / Q000188:drug therapy; D008727:Methotrexate / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D008954:Models, Biological; D014316:Tritium
D014316:Tritium; D008727:Methotrexate