Effects of chlorpromazine on exploration and habituation in the rat.
1. The effects of chlorpromazine, 2 and 4 mg/kg, on exploration were investigated under two independent influences-food deprivation and time of day.2. Rats had three 3-minute trials in a hole-board apparatus; hole-investigation (head-dips) and general motor activity were recorded.3. On trial 1 chlorpromazine reduced exploration to half the control level, but on trial 3 it had no effect on motor activity or head-dips.4. General activity habituated from trial 1 to 3 in all groups, but some of the drug groups did not show significant habituation of head-dips, due to the low level of responding on trial 1.
D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D002940:Circadian Rhythm; D005106:Exploratory Behavior / Q000187:drug effects*; D005508:Food Deprivation; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009068:Movement / Q000187:drug effects; D051381:Rats
D002746:Chlorpromazine