Lysine biosynthesis in Streptomyces lipmanii: implications in antibiotic biosynthesis.
Streptomyces lipmanii produces two beta-lactam antibiotics, penicillin N and 7-(5-amino-5-carboxyvaleramido)-7-methoxycephalosporanic acid. Both antibiotics contain alpha-aminoadipic acid side chains. In similar antibiotics produced by certain fungi, the alpha-aminoadipoyl moiety is derived from an intermediate in lysine biosynthesis. Our findings indicate, however, that in S. lipmanii, lysine is synthesized via alpha, epsilon-diaminopimelic acid-an entirely different biosynthetic route. This finding suggests not only a unique mechanism for the derivation of alpha-aminoadipate, but also that the system may be particularly amenable to genetic manipulation.
D000599:Amino Acids, Diamino / Q000378:metabolism; D002250:Carbon Radioisotopes; D002511:Cephalosporins / Q000096:biosynthesis*; D008239:Lysine / Q000096:biosynthesis* / Q000378:metabolism; D009154:Mutation; D010406:Penicillins / Q000096:biosynthesis*; D010867:Pimelic Acids / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*
D000599:Amino Acids, Diamino; D002250:Carbon Radioisotopes; D002511:Cephalosporins; D010406:Penicillins; D010867:Pimelic Acids; D008239:Lysine