title: Effect on body temperature in dogs of perfusion of cerebral ventricles with artificiaL CSF deficient in calcium or containing excess of sodium or calcium.
abstract: In anaesthetized dogs at room temperatures of 28-33 degrees C, the cerebral ventricles were perfused with artificial CSF from the left lateral ventricular to the aqueductal cannulae. The animals' temperatures were recorded from the rectum. Addition of Ca(++) in excess to the artificial CSF perfusing the ventricles produced hyperthermia and addition of Na+ in excess produced hypothermia. Perfusion with medium deficient in Ca(++) and containing sodium edetate produced hypothermia. The temperature effects of Na(+) or Ca(++) in excess were mutually antagonistic.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002118:Calcium / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D002552:Cerebral Ventricles / Q000187:drug effects; D002555:Cerebrospinal Fluid; D004285:Dogs; D005260:Female; D008297:Male; D010477:Perfusion; D012964:Sodium / Q000134:cerebrospinal fluid / Q000494:pharmacology*
chemical_list: D012964:Sodium; D002118:Calcium