BL-20803, a new, low-molecular-weight interferon inducer.
BL-20803 induced interferon in mice when administered via oral or parenteral routes. During multiple dosing with the drug at 48-h intervals, animals exhibited a hyporesponsive state to the third treatment. Inhibition of vaccinia virus infection was correlated with interferon induction.
D000818:Animals; D003959:Diamines / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008970:Molecular Weight; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D003959:Diamines; D007369:Interferon Inducers; D011720:Pyrazoles; D011804:Quinolines