Stimulation of ornithine decarboxylase activity and inhibition of S-adenosyl-L-methionine decarboxylase activity in leukaemic mice by methylglyoxal bis(guanylhydrazone).
Administration of methylglyoxal bis(guanylhydrazone) to leukaemic mice results in an early depression followed by a marked elevation of S-adenosyl-l-methionine decarboxylase activity. Further, there is an early prolonged increase in the activity of ornithine decarboxylase, the initial enzyme in the polyamine biosynthetic pathway. Because of the profound effects of methylglyoxal bis(guanylhydrazone) in vivo on the polyamine biosynthetic pathway, the drug can no longer be considered a specific inhibitor of spermidine synthesis.
D000241:Adenosine; D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003864:Depression, Chemical; D006037:Glyoxal / Q000494:pharmacology; D006835:Hydrazones / Q000494:pharmacology; D007939:Leukemia L1210 / Q000201:enzymology*; D008297:Male; D008715:Methionine; D051379:Mice; D009952:Ornithine; D011073:Polyamines / Q000096:biosynthesis; D012436:S-Adenosylmethionine; D013095:Spermidine / Q000096:biosynthesis; D013268:Stimulation, Chemical
D000578:Amidines; D006835:Hydrazones; D011073:Polyamines; D006037:Glyoxal; D012436:S-Adenosylmethionine; D008715:Methionine; D009952:Ornithine; D002262:Carboxy-Lyases; D000241:Adenosine; D013095:Spermidine