Comparative effects of 3-ethyl-8-methyl-1,3,8-triazabicyclo(4,4,0)decan-2-one and diethylcarbamazine against Litomosoides carinii in rodents.
3-Ethyl-8-methyl-1,3,8-triazabicyclo[4,4,0]decan-2-one and diethylcarbamazine were tested comparatively against Litomosoides carinii in Mongolian jirds and cotton rats. The drugs were compared in jirds by oral and by intraperitoneal administration. Comparisons in cotton rats were done by intraperitoneal administration. The drugs were given in a wide range of doses twice daily for 4 consecutive days. Parameters used for judging efficacy included the rate, degree, and duration of microfilaremia suppression as well as effects on adult worms. The two drugs exhibited similar strong but transient effect against microfilariae; neither drug had appreciable effect in killing adult worms.
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001372:Aza Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005368:Filariasis / Q000188:drug therapy*; D005369:Filaricides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005370:Filarioidea / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats; D012377:Rodentia
D000871:Anthelmintics; D001372:Aza Compounds; D001952:Bridged-Ring Compounds; D005369:Filaricides; D004049:Diethylcarbamazine