Anti-inflammatory and some other pharmacological effects of 3,4-trans-2,2-dimethyl-3-phenyl-4-(p-(beta-pyrrolidinoethoxy)-phenyl)-7-methoxy-chroman (Centchroman).
1. Anti-inflammatory, analgesic, antipyretic and other pharmacological activities of a new chroman derivative, Centchroman, have been described.2. Centchroman was found to possess significant anti-inflammatory action in the carrageenin-induced oedema test in mice and rats. It inhibited granuloma formation in the cotton pellet test. The anti-arthritic activity was also evident in formaldehyde-induced arthritis and adjuvant-induced arthritis in rats.3. Centchroman had a lower ulcerogenic index than phenylbutazone.4. The mechanism of the anti-inflammatory action of Centchroman seemed to be independent of endogenous adrenocortical hormones or of its weak oestrogenic activity.5. Centchroman antagonized phenylquinone writhing and bradykinin-induced bronchospasm but was devoid of any antipyretic activity.
D000311:Adrenal Glands / Q000187:drug effects; D000698:Analgesia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001168:Arthritis / Q000517:prevention & control; D001578:Benzopyrans / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001920:Bradykinin / Q000037:antagonists & inhibitors; D001986:Bronchial Spasm / Q000517:prevention & control; D002415:Cats; D004487:Edema / Q000517:prevention & control; D005260:Female; D006099:Granuloma / Q000517:prevention & control; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008297:Male; D051379:Mice; D009130:Muscle, Smooth / Q000187:drug effects; D009541:Nictitating Membrane / Q000187:drug effects; D010647:Phenyl Ethers / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D011759:Pyrrolidines / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011809:Quinones / Q000037:antagonists & inhibitors; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced
D000893:Anti-Inflammatory Agents; D001578:Benzopyrans; D010647:Phenyl Ethers; D011759:Pyrrolidines; D011809:Quinones; D001920:Bradykinin