title: Porphyrin-heme pathway: regulation by intermediates in bile acid synthesis.
abstract: Dihydroxycoprostane and trihydroxycoprostane, intermediates in normal bile acid synthesis in the liver, enhanced the rate of porphyrin synthesis in cultured liver cells by induction of delta-aminolevulinate synthetase, the rate-limiting enzyme for this pathway. Other 5beta-cholestane derivatives and cholest-5-ene derivatives were ineffective. The selectivity of the induction may indicate that the above-mentioned coprostanes have a physiological role in porphyrin synthesis.
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis / Q000494:pharmacology; D002478:Cells, Cultured; D002642:Chick Embryo; D002776:Cholestanes / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002777:Cholestanols; D002784:Cholesterol / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D006418:Heme / Q000494:pharmacology; D006914:Hydroxysteroids / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D011166:Porphyrins / Q000096:biosynthesis*
chemical_list: D001647:Bile Acids and Salts; D002776:Cholestanes; D002777:Cholestanols; D006914:Hydroxysteroids; D011166:Porphyrins; C007426:dihydroxycoprostane; D006418:Heme; C009561:3,7,12-trihydroxycoprostane; D002784:Cholesterol; D000624:5-Aminolevulinate Synthetase