Effects of a new tetrahydroisoquinoline (NC-7197) in experimental cardiogenic shock.
Intravenous administration of 1.0 mg/kg of NC-7197 to open and closed-chest anaesthetized dogs immediately after induction of cardiogenic shock by miliary coronary embolization resulted in significant haemodynamic improvement and prolonged survival. These results suggest that NC-7197 may prove to be valuable in the initial management of myocardial infarction complicated by hypotension and shock.
D000818:Animals; D001011:Aorta; D001794:Blood Pressure; D002302:Cardiac Output; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D012770:Shock, Cardiogenic / Q000188:drug therapy*; D013441:Sulfinic Acids / Q000627:therapeutic use
D007546:Isoquinolines; D013441:Sulfinic Acids