Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n.
A number of actinomycetes isolated from soil were found to produce one or more members of a new family of antibiotics, the cephamycins, which are structurally related to cephalosporin C. The cephamycins were produced in submerged fermentation in a wide variety of media by one or more of eight different species of Streptomyces, including a newly described species, S. lactamdurans. These antibiotics exhibit antibacterial activity against a broad spectrum of bacteria which includes many that are resistant to the cephalosporins and penicillins.
D000190:Actinomyces / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002511:Cephalosporins / Q000096:biosynthesis; D008826:Microbial Sensitivity Tests; D013302:Streptomyces / Q000378:metabolism*; D047090:beta-Lactams / Q000096:biosynthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D047090:beta-Lactams