Gastric mucosal blood flow during pentagastrin- and histamine-stimulated acid secretion in the rat.
1. Gastric mucosal blood flow was studied in the rat by means of a [(14)C]-aniline clearance technique.2. There was a significant correlation between clearance and stimulated acid secretion.3. No significant difference was found in the relationship between clearance and acid secretion during submaximal stimulation with either pentagastrin or histamine.4. Estimates of mucosal blood flow per unit acid secretion by [(14)C]-aniline clearance in the rat were similar to those reported with aminopyrine clearance in the dog and cat.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001783:Blood Flow Velocity; D002250:Carbon Radioisotopes; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply*; D006632:Histamine / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects
D000814:Aniline Compounds; D002250:Carbon Radioisotopes; D000632:Aminopyrine; D006632:Histamine; D010418:Pentagastrin