Interaction between tyramine and iproniazid on guinea-pig atria.
The inhibition of monoamine oxidase (MAO) by iproniazid may be antagonized by large doses of tyramine as shown by the restoration, or otherwise, of inotropic responses to tyramine in isolated atria from guinea-pigs that had been treated with reserpine.
D000818:Animals; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D007490:Iproniazid / Q000494:pharmacology*; D008996:Monoamine Oxidase Inhibitors; D009638:Norepinephrine / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D012110:Reserpine; D007490:Iproniazid; D009638:Norepinephrine; D014439:Tyramine