Biosynthesis of monensin.
The biosynthesis of monensin by Streptomyces cinnamonensis was studied by using (14)C-labeled glucose, acetate, propionate, butyrate, and methionine. The results indicated that the antibiotic is synthesized from five acetate, seven propionate, and one butyrate molecules. The o-methyl group of monensin is derived from methionine, whereas the terminal hydroxymethyl group is incorporated from acetate.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005663:Furans / Q000096:biosynthesis; D011714:Pyrans / Q000096:biosynthesis; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D005232:Fatty Acids, Volatile; D005663:Furans; D011714:Pyrans