Failure of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ICN 1229) to stimllate interferon.
In cultured cells, Virazole failed to stimulate either interferon or a cellular resistance which continued in its absence. Serum from Virazole-treated mice likewise contained no demonstrable interferon.
D000577:Amides / Q000494:pharmacology*; D002478:Cells, Cultured; D005663:Furans / Q000494:pharmacology*; D007369:Interferon Inducers; D014230:Triazoles / Q000494:pharmacology*; D014776:Virus Cultivation
D000577:Amides; D005663:Furans; D007369:Interferon Inducers; D014230:Triazoles