Dopamine and serotonin metabolism in hepatic encephalopathy.
Patients with stupor or coma from fulminant hepatic failure were found to have high cerebrospinal fluid concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA), metabolites of dopamine and serotonin respectively. Excessive amounts of their precursors-phenylalanine and tyrosine and free tryptophan-were found in the patients' plasma. Methionine, which participates in dopamine degradation, was also much increased. Similar disturbances were found in patients suffering an acute exacerbation of chronic encephalopathy. These abnormalities would be consistent with other evidence of an increased turnover of serotonin and possibly dopamine in the brain during hepatic encephalopathy.
D000082:Acetaminophen / Q000506:poisoning; D000208:Acute Disease; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000134:cerebrospinal fluid / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006221:Halothane / Q000009:adverse effects; D006501:Hepatic Encephalopathy / Q000097:blood / Q000134:cerebrospinal fluid / Q000139:chemically induced / Q000378:metabolism*; D006506:Hepatitis A / Q000097:blood; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008715:Methionine / Q000378:metabolism; D008875:Middle Aged; D010649:Phenylalanine / Q000097:blood; D012701:Serotonin / Q000134:cerebrospinal fluid / Q000378:metabolism*; D014364:Tryptophan / Q000097:blood; D014443:Tyrosine / Q000097:blood
D005230:Fatty Acids, Nonesterified; D012701:Serotonin; D000082:Acetaminophen; D014443:Tyrosine; D010649:Phenylalanine; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D008715:Methionine; D006221:Halothane; D004298:Dopamine; D006719:Homovanillic Acid