title: Leukoencephalopathy following the administration of methotrexate into the cerebrospinal fluid in the treatment of primary brain tumors.
mesh_terms: D000293:Adolescent; D001344:Autopsy; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002552:Cerebral Ventricles / Q000473:pathology; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D004806:Ependymoma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D009461:Neurologic Manifestations
chemical_list: D008727:Methotrexate