[Hexobarbital sleep in rats treated with polyvinylpyrrolidone].
Young male rats, breed Wistar, underwent daily intravenous injections with 10 ml per kilogram body weight polyvinyl pyrrolidone, over a period of five days. As a control group, non injected rats of the same age were used. The duration of sleep after interaperitoneal injection of hexobarbital natrium at dose 100 mg/kg weight was checked in both groups. It was established that in the animals treated with polyvinyl pyrrolidone the duration of sleep was shorter. In a second group of animals, treated with polyvinyl pyrrolidone, the concentration of aminopyrine N-demethylase in the liver was traced.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation; D006591:Hexobarbital / Q000037:antagonists & inhibitors*; D008099:Liver / Q000201:enzymology; D011205:Povidone / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D006591:Hexobarbital; D000633:Aminopyrine N-Demethylase; D011205:Povidone
Kheksobarbitalov sun pri plukhove, tretirani s polivinilpirolidon