[Interventions with drugs on blood deposits].
The aim of this study is to see if some drugs are able to lodge blood in specific organs, in the Rat. The metodic is the follow: the rat's carotid is connected to a container of saline plasma; the animal is fastened to a balance with central fulcrum; by the relation between the movements of the balance and the liquid entered and come out from the container, because of the action of the drugs on the animal, it is possible to stabilish the part of the body from which the blood is moved. The prevailing effect of 0,25-1 mug/kg doses of isoprenalin is an accumulation of blood in the liver: this blood comes from caudal parts to these organs. The enteramin's effect, for doses of 3-30 mug/kg, is an accumulation of blood in the liver and in the torax. The carbamylcholin's effect, for doses of 1-4 mug/kg, is an accumulation of blood in the abdomen and partially in the liver; this blood comes from cranial parts to the abdomen.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008102:Liver Circulation / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology
D006584:Hexamethonium Compounds; D014667:Vasopressins; D006632:Histamine; D002217:Carbachol; D007545:Isoproterenol; D004298:Dopamine; D009638:Norepinephrine
Interventi con farmaci sui depositi di sangue