Potential usefulness of single-dose acute physical dependence on and tolerance to morphine for the evaluation of narcotic antagonists.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004361:Drug Tolerance / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009021:Morphine Dependence; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced*; D013997:Time Factors
D000700:Analgesics; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine