title: Cholera toxin: interaction of subunits with ganglioside GM1.
abstract: Vibrio cholerae exotoxin is an aggregate of two different noninterconvertible subunits (molecular weights about 15,000 and about 25,000). Only the smaller subunit reacts with ganglioside G(M1), a possible biological receptor. The larger subunit, found only in active toxin molecules, can be eluted with 8 molar urea from insoluble complexes of toxin, ganglioside, and cerebroside.
mesh_terms: D001665:Binding Sites; D002554:Cerebrosides; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D005732:Gangliosides; D008970:Molecular Weight; D014118:Toxins, Biological; D014508:Urea; D014734:Vibrio cholerae
chemical_list: D002554:Cerebrosides; D005732:Gangliosides; D014118:Toxins, Biological; D014508:Urea