Calcium absorption and calcium-binding protein synthesis: solanum malacoxylon reverses strontium inhibition.
The ingestion of diets containing high concentrations of stable strontium inhibits calcium absorption and intestinal calcium-binding protein synthesis and, as shown by others, does so by inhibiting the conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, the active form of vitamin D. The addition of the South American plant Solanum malacoxylon to strontium-containing diets counteracts the inhibitory action of dietary strontium, thereby indicating that the plant contains a factor which can mimic the action of 1,25-dihydroxycholecalciferol and representing the first such factor identified in a botanical source.
D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002352:Carrier Proteins / Q000096:biosynthesis*; D002645:Chickens; D004032:Diet; D004100:Dihydroxycholecalciferols / Q000378:metabolism / Q000494:pharmacology; D004386:Duodenum / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D010758:Phosphorus / Q000097:blood; D010936:Plant Extracts; D010944:Plants; D011485:Protein Binding; D013020:South America; D013324:Strontium / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology
D002352:Carrier Proteins; D004100:Dihydroxycholecalciferols; D010936:Plant Extracts; D010758:Phosphorus; D002118:Calcium; D013324:Strontium