Selective inhibition of Newcastle disease virus-induced glycoprotein synthesis by D-glucosamine hydrochloride.
d-Glucosamine selectively affected the synthesis of virus-induced glycoproteins in Newcastle disease virus-infected chick fibroblasts, but had no effect upon post-translational cleavage of the glycoprotein precursor for one of the two major glycoproteins of the mature virion. In response to glucosamine, at least one of the two virus-induced glycoproteins is formed in reduced quantity and the second is either not formed or has an electrophoretic mobility identical to that of another virus-induced protein.
D000818:Animals; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D002642:Chick Embryo; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts; D005944:Glucosamine / Q000494:pharmacology*; D006023:Glycoproteins / Q000096:biosynthesis*; D007532:Isoleucine; D009522:Newcastle disease virus / Q000187:drug effects; D010452:Peptide Biosynthesis; D012967:Sodium Dodecyl Sulfate; D014316:Tritium; D014764:Viral Proteins / Q000096:biosynthesis*
D002250:Carbon Radioisotopes; D006023:Glycoproteins; D014764:Viral Proteins; D007532:Isoleucine; D014316:Tritium; D012967:Sodium Dodecyl Sulfate; D005944:Glucosamine