Arachidonic acid causes sudden death in rabbits.
Injection of sodium arachidonate (1.4 milligrams per kilogram) into the marginal ear veins of rabbits caused death within 3 minutes. Histological examination showed platelet thrombi in the microvasculature of the lungs. Rabbits were protected from the lethal effects of arachidonic acid by pretreatment with aspirin. Fatty acids closely related to arachidonic acid did not cause death.
D000818:Animals; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000633:toxicity*; D001241:Aspirin / Q000494:pharmacology; D003645:Death, Sudden; D007275:Injections, Intravenous; D008833:Microcirculation; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011652:Pulmonary Circulation / Q000187:drug effects; D011817:Rabbits; D013927:Thrombosis / Q000139:chemically induced*
D001095:Arachidonic Acids; D001241:Aspirin