Motor nerve conduction velocity in peroneal muscular atrophy: evidence for genetic heterogeneity.
Measurements of motor nerve conduction velocity are reported in 88 subjects from 20 families in which a clinical diagnosis of peroneal muscular atrophy had been made in the index cases. The values display a bimodal distribution. The majority of cases show a substantially reduced conduction velocity, a smaller group displaying velocities within the normal range or only slightly decreased. This difference was demonstrated to have a genetic basis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D008875:Middle Aged; D009133:Muscular Atrophy / Q000235:genetics* / Q000503:physiopathology; D009431:Neural Conduction; D010525:Peripheral Nerves / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000503:physiopathology; D012881:Skin Temperature; D014459:Ulnar Nerve / Q000503:physiopathology