The effects of manganese on aconitine-induced ventricular tachycardia.
Isolated rabbit heart with independent perfusion of a small left ventricular area was used to study the effect of manganese ions on aconitine-induced ventricular tachycardia. Manganese chloride 4 mM in Locke solution exhibited a constant preventive or suppressive effect versus aconitum-induced rhythm disorders. It is concluded that the interpretation of aconitine cardiotoxic effects on the sole basis of phase 3 modifications require further evidence, and that an increased diastolic depolarization rate may well explain, at least in this experimental model, the genesis of arrhythmias induced by this drug.
D000157:Aconitine; D031841:Aconitum / Q000031:analogs & derivatives; D000818:Animals; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology; D008345:Manganese / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D008345:Manganese; D000157:Aconitine