On the relation of dystonic movements to serum thyroxine levels.
A patient with psychomotor retardation secondary to delayed treatment of cretinism developed abnormal dystonic movements in the absence of other signs of toxicity during levothyroxine replacement therapy at a serum thyroxine level of 16 mug./100 ml. The dystonic movements disappeared when the serum thyroxine level fell. The abnormal movements were considered to be related to high thyroxine levels in this patient with pre-existing central nervous system dysfunction.
D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy; D009069:Movement Disorders / Q000139:chemically induced*; D013974:Thyroxine / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*
D013974:Thyroxine