title: Left atrial receptors and the antidiuretic hormone.
abstract: 1. Stimulation of left atrial receptors by distending balloons located at the junction between the pulmonary veins and the left atrium and in the body of the left atrium resulted in a diuresis in anaesthetized dogs.2. In the same dogs the diuresis was not consistently associated with a reduction in the antidiuretic activity of plasma as compared with that during the initial control period. The antidiuretic activity of dog plasma was assayed in water-loaded rats anaesthetized with ethanol.3. Intravenous injections of vasopressin suppressed a water diuresis in water-loaded dogs anaesthetized with chloralose. The changes in antidiuretic activity of dog plasma which resulted from these injections were reliably detected by the bio-assay in the rat.4. It is concluded that the diuretic response to the stimulation of left atrial receptors is not accompanied by a reduction in the plasma antidiuretic hormone level.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D006321:Heart / Q000294:innervation*; D006325:Heart Atria / Q000294:innervation; D006339:Heart Rate; D011312:Pressure; D051381:Rats; D011984:Sensory Receptor Cells / Q000502:physiology*; D012964:Sodium / Q000652:urine; D013864:Thioglycolates / Q000494:pharmacology; D014546:Urinary Catheterization; D014667:Vasopressins / Q000097:blood* / Q000494:pharmacology
chemical_list: D013864:Thioglycolates; D014667:Vasopressins; D012964:Sodium