DNA synthesis and mitosis in well-differentiated mammalian cardiocytes.
Incorporation of [(3)H]thymidine into nuclei of heart cells of 2-day-old rats indicates that neonatal cardiac cells containing well-aligned myofibrils synthesize DNA. In these highly differentiated cells, neither the presence of contractile proteins nor their organization into myofibrils inhibits either DNA synthesis or mitosis.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002454:Cell Differentiation; D004247:DNA / Q000096:biosynthesis*; D008938:Mitosis; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D009210:Myofibrils; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D004247:DNA; D013936:Thymidine