Procainamide-induced SLE and lymphoreticular disorders.
A 56-year-old male patient diagnosed as a case of procainamide-induced systemic lupus erythematosus (SLE) was found to have a lymphoproliferative disorder at postmortem examination.Contrary to other immune disorders, the association of SLE with neoplasia is a rare occurrence. The present case raises the question of whether a relationship exists between the lupus diathesis and lymphoreticular neoplasia. The study of the incidence of neoplasia in families of patients with SLE may prove helpful in establishing this relationship.
D001018:Aortic Diseases / Q000175:diagnosis / Q000601:surgery; D001344:Autopsy; D001766:Blindness / Q000209:etiology; D001853:Bone Marrow; D004077:Digoxin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006331:Heart Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000009:adverse effects* / Q000627:therapeutic use; D011802:Quinidine / Q000627:therapeutic use; D012161:Retinal Artery; D013154:Spleen / Q000473:pathology; D013923:Thromboembolism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D014859:Warfarin / Q000627:therapeutic use
D014859:Warfarin; D004077:Digoxin; D006493:Heparin; D011802:Quinidine; D011342:Procainamide