Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions.
Leucocytes from 38 patients with Crohn's disease were tested for evidence of migration inhibition in the presence of preparations of colon from a patient with this disease. The occurrence of migration inhibition showed a positive correlation with clinically active disease and a negative correlation with immunosuppressive treatment. It was not seen with leucocytes from 12 healthy subjects.
D000328:Adult; D002464:Cell Migration Inhibition; D003106:Colon / Q000276:immunology; D003424:Crohn Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008861:Microsomes / Q000276:immunology; D008928:Mitochondria / Q000276:immunology