Studies of the stability and toxicity of zinc polyacrylate (polycarboxylate) cements (PAZ).
Zinc polycarboxylate cement (PAZ) was shown to actively bond to 45Ca in vitro, with maximum uptake occurring at a Ca+2 concentration of 0.2 mg/ml. When the resultant PAZ-45Ca complex was subsequently incubated in the presence of high levels of unlabeled Ca+2, there was an exchange between the 45Ca bond to the cement and the Ca+2 in solution. When PAZ prepared using 65Zn was incubated with high levels of Ca+2, there was no exchange between the Ca and the 65Zn. 14C-PA failed to be taken up by L-cells in tissue culture, during 16 division cycles. Using radioactive PAZ prepared from 14C-PA, the PA moiety of the cement was shown to be extremely insoluble and stable in vivo.
D000179:Acrylates; D000180:Acrylic Resins / Q000633:toxicity; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D001840:Dental Bonding; D003738:Dental Cements; D004355:Drug Stability; D007739:L Cells / Q000378:metabolism; D008297:Male; D011076:Polycarboxylate Cement / Q000378:metabolism / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012995:Solubility; D015032:Zinc / Q000378:metabolism / Q000633:toxicity
D000179:Acrylates; D000180:Acrylic Resins; D002132:Calcium Radioisotopes; D002250:Carbon Radioisotopes; D003738:Dental Cements; D011076:Polycarboxylate Cement; D015032:Zinc; D002118:Calcium