Selective pancreatic enzyme secretion due to a new peptide called chymodenin.
Chymodenin, a peptide newly isolated from porcine duodenum, elicited a rapid threefold increase in secretion of chymotrypsinogen while increasing secrelion of total protein by only, about 40 percent; lipase secretion was unaffected. The pancreas appears able, under chymodenin stimulation, to rapidly alter the transport of an individual enzyme as opposed to producing en masse secretion of enzyme.
D000818:Animals; D002919:Chymotrypsinogen / Q000378:metabolism*; D004386:Duodenum / Q000032:analysis; D008049:Lipase / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013552:Swine; D014020:Tissue Extracts / Q000494:pharmacology
D010455:Peptides; D011506:Proteins; D014020:Tissue Extracts; D002919:Chymotrypsinogen; D008049:Lipase