title: Jaundice after repeated exposure to halothane: an analysis of Reports to the Committee on Safety of Medicines.
abstract: Analysis of data derived from 130 reports of jaundice occurring after anaesthesia with halothane showed a significant relation between the number of exposures to this anaesthetic and the rapidity with which jaundice develops after exposure. This is considered to provide strong evidence of a cause-effect relationship between the use of halothane and jaundice. Out of 114 patients with complete anaesthetic histories 94 (82%) had been exposed more than once; of those so exposed 80% had been anaesthetized with halothane more than once within 28 days. Altogether 66 (51%) of the 130 patients died.
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000769:Anesthesia, Inhalation / Q000009:adverse effects; D004739:England; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006506:Hepatitis A / Q000401:mortality; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000401:mortality; D008107:Liver Diseases / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010606:Pharmacy and Therapeutics Committee; D013997:Time Factors; D014852:Wales
chemical_list: D006221:Halothane