title: Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme.
abstract: We have examined a polymorphism for liver GOX in inbred strains of the mouse Mus musculus. Genetic studies demonstrated that the two phenotypes for this enzyme present in BALB/C and NZC parental strains segregated as though they were controlled by codominant alleles at a single autosomal locus (GOX) which mapped closely to the agouti locus in linkage group V. Kidney HAOX activity is invariant in these inbred strains and is encoded by a separate genetic locus designated HAOX. BALB/C x NZC F(1) hybrid mice exhibited three intermediate forms of liver GOX activity, in addition to the parental enzymes, which is consistent with a tetrameric subunit structure.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000096:biosynthesis*; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004592:Electrophoresis, Starch Gel; D005260:Female; D005796:Genes; D005799:Genes, Dominant; D008040:Genetic Linkage; D006824:Hybridization, Genetic; D007527:Isoenzymes / Q000096:biosynthesis*; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D009928:Organ Specificity; D011110:Polymorphism, Genetic
chemical_list: D007527:Isoenzymes; D000429:Alcohol Oxidoreductases