title: Carcinogenicity of methylchrysenes.
abstract: Methylchrysenes are present in tobacco smoke and are suspected to contribute to the tumorigenicity of this inhalant. Chrysene and the six isomeric methylchrysenes were obtained in high purity (99.9 percent); they were tested on mouse skin for tumor initiating activity and carcinogenicity. The 3- and 6-methylchrysenes are strong tumor initiators, whereas the other five chrysenes have moderate initiatinig activity. 5-Methylchrysene is a strong carcinogen; the other chrysenes are inactive or weak carcinogens.
mesh_terms: D000818:Animals; D002273:Carcinogens; D002277:Carcinoma / Q000139:chemically induced*; D005260:Female; D051379:Mice; D010616:Phenanthrenes; D010936:Plant Extracts / Q000009:adverse effects; D010947:Plants, Toxic; D012878:Skin Neoplasms / Q000139:chemically induced*; D013329:Structure-Activity Relationship; D014026:Nicotiana
chemical_list: D002273:Carcinogens; D010616:Phenanthrenes; D010936:Plant Extracts