Acceleration of hepatic sterol synthesis after a single dose of the porphyrogenic chemical allylisopropylacetamide.
Hepatic sterol synthesis is accelerated in animals after a single dose of allylisopropylacetamide, a chemical known to be porphyrogenic. Evidence is provided to show that enhanced sterol biosynthesis is due to an increased formation of mevalonic acid, indicating that the primary site of action of the chemical is on one or more steps in the pathway from acetate to mevalonate.
D000081:Acetamides / Q000494:pharmacology*; D000085:Acetates / Q000378:metabolism; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D002250:Carbon Radioisotopes; D011232:Chemical Precipitation; D002784:Cholesterol / Q000096:biosynthesis; D004072:Digitonin; D005215:Fasting; D005260:Female; D007422:Intestines / Q000502:physiology; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008798:Mevalonic Acid / Q000096:biosynthesis; D011164:Porphyrias / Q000139:chemically induced / Q000378:metabolism; D051381:Rats; D013261:Sterols / Q000096:biosynthesis*; D013268:Stimulation, Chemical; D014316:Tritium; D014867:Water / Q000378:metabolism
D000081:Acetamides; D000085:Acetates; D002250:Carbon Radioisotopes; D013261:Sterols; D014867:Water; D014316:Tritium; D000502:Allylisopropylacetamide; D002784:Cholesterol; D004072:Digitonin; D008798:Mevalonic Acid