Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.
D000429:Alcohol Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde / Q000138:chemical synthesis / Q000627:therapeutic use; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D007822:Laryngeal Neoplasms; D007939:Leukemia L1210 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012265:Ribonucleotides; D012510:Sarcoma 180 / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D012265:Ribonucleotides; D013882:Thiosemicarbazones; D005557:Formaldehyde; D000429:Alcohol Oxidoreductases