Regulation of amino acid transport in kidney cortex of newborn rats.
After incubation at 37 degrees C the subsequent uptake of alpha-aminoisobutyric acid, cycloleucine, glycine, and L-proline by newborn (as compared to adult) rat kidney cortex slices is enhanced. The effect is abolished by the presence of cycloheximide, actinomycin D, and high concentrations of the above-mentioned amino acids in the medium during the 37 degrees C incubation prior to measurement of uptake. The data suggest that there is an adaptive control mechanism which is expressed on incubation at 37 degrees C and which can regulate amino acid transport in newborn rat kidney cortex.
D000596:Amino Acids / Q000378:metabolism*; D000621:Aminoisobutyric Acids / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003513:Cycloheximide / Q000494:pharmacology; D003517:Cyclopentanes / Q000378:metabolism; D003609:Dactinomycin / Q000494:pharmacology; D003864:Depression, Chemical; D005998:Glycine / Q000378:metabolism; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008759:Methylglycosides / Q000378:metabolism; D011392:Proline / Q000378:metabolism; D051381:Rats; D013696:Temperature; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D002250:Carbon Radioisotopes; D003517:Cyclopentanes; D008759:Methylglycosides; D003609:Dactinomycin; D003513:Cycloheximide; D011392:Proline; D007930:Leucine; D014633:Valine; D008239:Lysine; D005998:Glycine