Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by L-DOPA plus decarboxylase inhibition.
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001923:Brain Chemistry; D002375:Catalepsy / Q000139:chemically induced; D002421:Caudate Nucleus / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D006892:Hydroxydopamines / Q000032:analysis / Q000494:pharmacology*; D007267:Injections; D008297:Male; D008856:Microscopy, Fluorescence; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000700:Analgesics; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D006892:Hydroxydopamines; D004295:Dihydroxyphenylalanine; D009020:Morphine