title: Enduring learning deficits and cerebral synaptic malformation from exposure to 10 parts of halothane per million.
abstract: Chronic exposure of rats to 10 parts of halothane per million during early life produced later deficits in learning a shock-motivated light-dark discrimination and a food-motivated maze pattern, correlated with enduring synaptic nembrane malformation in cerebral cortex. Adult exposure had no effect. Halothane may provide a useful analytical tool for study of brain. The behavioral-ultrastructural techniques also suggest a standard for assessing the safety of trace toxicants with central nervous system effects.
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects* / Q000473:pathology; D004193:Discrimination Learning / Q000187:drug effects*; D004780:Environment, Controlled; D004781:Environmental Exposure; D006128:Growth; D006221:Halothane / Q000494:pharmacology / Q000633:toxicity*; D006801:Humans; D008568:Memory / Q000187:drug effects; D008854:Microscopy, Electron; D051381:Rats; D013569:Synapses / Q000187:drug effects*; D013570:Synaptic Membranes / Q000187:drug effects
chemical_list: D006221:Halothane