Enhancement of pentagastrin-induced gastric acid secretion by clonidine in the conscious dog.
The effect of intravenous clonidine on pentagastrin-induced gastric acid secretion has been studied in conscious dogs with Heidenhain pouches. Dose-dependent enhancement of secretion was found in response to clonidine (5-20 mu/kg). Clonidine (20 mug/kg) increased the maximal secretory rate to pentagastrin to a value not significantly different from the maximal response to histamine.
D000818:Animals; D001783:Blood Flow Velocity; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects; D014316:Tritium
D014316:Tritium; D006632:Histamine; D010418:Pentagastrin; D003000:Clonidine