Effects of reserpine and chlorpromazine on 5-hydroxytryptamine uptake of platelets from migrainous and control subjects.
Platelet aggregation experiments confirm differences between the 5-hydroxytryptamine (5-HT) receptors of migrainous and control platelets. However, no differences have been found in 5-HT uptake, in the presence of reserpine or chlorpromazine, into migrainous and control platelets. The results support the hypothesis that receptors for 5-HT induced platelet aggregation provide a model for vascular receptors causing constriction and are distinct from those transferring 5-HT through the platelet membrane.
D001792:Blood Platelets / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002462:Cell Membrane / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D006801:Humans; D008881:Migraine Disorders / Q000097:blood* / Q000378:metabolism; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism*
D002250:Carbon Radioisotopes; D011955:Receptors, Drug; D012701:Serotonin; D012110:Reserpine; D002746:Chlorpromazine