Ammonium chloride poisoning in chronic renal disease.
A 58-year-old woman with a long history of renal stone disease and urinary tract infection presented to the emergency room with exhaustion and air hunger. Laboratory data confirmed profound metabolic acidosis. Unduly large quantities of bicarbonate and potassium were required for correction of the deficits. She had been taking 6 g daily of ammonium chloride as a urine-acidifying agent for a period of six months in addition to agents directed against urinary tract infection. The combination of impaired renal function and effective hydrogen ion loading resulted in profound systemic acidosis. The metabolic derangements associated with the administration of ammonium chloride and its use as a therapeutic agent are discussed.
D000138:Acidosis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000652:urine; D000643:Ammonium Chloride / Q000506:poisoning* / Q000627:therapeutic use; D001639:Bicarbonates / Q000097:blood / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000188:drug therapy; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011704:Pyelonephritis / Q000188:drug therapy*; D012964:Sodium / Q000627:therapeutic use
D001639:Bicarbonates; D004573:Electrolytes; D000643:Ammonium Chloride; D002245:Carbon Dioxide; D012964:Sodium; D010100:Oxygen