title: Genetic mapping of Ir locus in man: linkage to second locus of HL-A.
abstract: Fifty-seven members of a family that spanned three generations were studied for antigen E and ragweed skin sensitivity and HL-A antigens. There was significant association between the haplotype HL-A 2-12 and antigen E skin hypersensitivity (F = .22 to .26) in this family. The map order is first locus of HL-A, second locus of HL-A, and IrE. These determinants are considered to be part of the linkage group HL-1.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D006649:Histocompatibility Antigens; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D011058:Pollen; D011995:Recombination, Genetic; D012882:Skin Tests
chemical_list: D000485:Allergens; D006649:Histocompatibility Antigens