[Relationship between the antihypertensive activity of methyldopa and the appearance of its metabolites in the heart and brain of the hypertensive rat].
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001545:Benserazide / Q000494:pharmacology; D001711:Biotransformation; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D004220:Disulfides / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D006834:Hydrazines / Q000494:pharmacology; D006973:Hypertension / Q000378:metabolism*; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D008697:Methane / Q000378:metabolism; D008750:Methyldopa / Q000378:metabolism / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013565:Sympatholytics / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D000959:Antihypertensive Agents; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004220:Disulfides; D006834:Hydrazines; D007093:Imidazoles; D013565:Sympatholytics; D014316:Tritium; D008750:Methyldopa; D001545:Benserazide; D004299:Dopamine beta-Hydroxylase; D008697:Methane; D004221:Disulfiram; D004298:Dopamine; D009638:Norepinephrine
Relation entre l'activité antihypertensive de l'a-méthyldopa et l'apparition de ses métabolites dans le coeur et le cerveau des rats hypertendus.