title: Concentration polarization in an ultrafiltering capillary.
abstract: Concentration polarization, the accumulation of retained solute next to an ultrafiltering membrane, elevates osmotic pressure above that which would exist in the absence of polarization. For ultrafiltration in a cylindrical tube, use of the radially averaged solute concentration results in an underestimate of osmotic pressure, yielding an effective hydraulic permeability (k) less than the actual membrane hydraulic permeability (k(m)). The extent to which k and k(m) might differ in an ultrafiltering capillary has been examined theoretically by solution of the momentum and species transport equations for idealized capillaries with and without erythrocytes. For diameters, flow velocities, protein concentrations and diffusivities, and ultrafiltration pressures representative of the rat glomerular capillary network, results indicate that the effects of polarization are substantial without erythrocytes (k/k(m) = 0.7) and persist, but to a lesser extent, with erythrocytes (k/k(m) = 0.9), the reduction in polarization in the latter case being due to enhanced plasma mixing. In accord with recent experimental findings in rats, k is found to be relatively insensitive to changes in glomerular plasma flow rate.
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D002196:Capillaries / Q000166:cytology / Q000502:physiology*; D002199:Capillary Permeability; D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability; D004912:Erythrocytes / Q000378:metabolism / Q000502:physiology; D005919:Glomerular Filtration Rate; D008433:Mathematics; D008954:Models, Biological; D009997:Osmotic Pressure; D010539:Permeability; D014462:Ultrafiltration
chemical_list: D001798:Blood Proteins