Prevention of postoperative deep venous thrombosis in legs by orally administered hydroxychloroquine sulphate.
In a series of patients given hydroxychloroquine sulphate by mouth before and after major surgery the incidence of deep venous thrombosis in the legs, as assessed by iodine-125-tagged fibrinogen scanning and venography, was reduced to 5% compared with an incidence of 16% in a similar untreated group of patients.
D000284:Administration, Oral; D000368:Aged; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D007457:Iodine Radioisotopes; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D011183:Postoperative Complications / Q000517:prevention & control*; D011468:Prostatectomy; D012737:Sex Factors; D013431:Sulfates / Q000627:therapeutic use; D013924:Thrombophlebitis / Q000517:prevention & control*
D007457:Iodine Radioisotopes; D013431:Sulfates; D006886:Hydroxychloroquine; D005340:Fibrinogen