title: Degree and duration of reversal by naloxone of effects of morphine in conscious subjects.
abstract: The effects of intravenous naloxone on several of the actions of intravenous morphine (mean dose 30 mg/70 kg) were studied in six volunteer subjects. Naloxone produced a well defined reversal of the respiratory depression, analgesia, and miotic and subjective effects of the morphine. The agonist action of morphine outlasted the antagonist action of a single dose of naloxone. The effect of repeated doses of naloxone was also short-lived, but continuous infusions were effective in maintaining reversal.
mesh_terms: D001143:Arousal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide; D002404:Catheterization; D003250:Constriction; D006801:Humans; D008297:Male; D009020:Morphine / Q000037:antagonists & inhibitors*; D009270:Naloxone / Q000494:pharmacology*; D009325:Nausea; D010146:Pain; D011680:Pupil / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
chemical_list: D002245:Carbon Dioxide; D009270:Naloxone; D009020:Morphine