Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia.
The existence of cortical dopamine nerve terminals is demonstrated with a highly sensitive modification of the Falck-Hillarp fluorescence technique. This confirms previous biochemical reports of high dopamine levels in the cortex. The histochemistry reveals that the distribution is regional and confined to the limbic cortex.
D000818:Animals; D002230:Carbidopa / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004220:Disulfides / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008032:Limbic System / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D011955:Receptors, Drug; D012110:Reserpine / Q000494:pharmacology; D012559:Schizophrenia / Q000378:metabolism*
D004220:Disulfides; D007093:Imidazoles; D011955:Receptors, Drug; D004295:Dihydroxyphenylalanine; D012110:Reserpine; D004299:Dopamine beta-Hydroxylase; D002230:Carbidopa; D004298:Dopamine