Subacute brain-stem encephalitis.
A 65 year old man developed progressive signs of pontine and medullary dysfunction with striking bilateral paralysis of lateral gaze, dysarthria, dysphagia, and ataxia. A respiratory death occurred seven months from the onset. Pathological examination revealed focal brain-stem changes of perivascular lymphocytic cuffing, microglial infiltration, glial nodules, and neuronophagia. No underlying malignancy or general disease impairing immunity mechanisms was discovered.
D000368:Aged; D001259:Ataxia / Q000209:etiology / Q000473:pathology; D001930:Brain Injuries / Q000150:complications; D001933:Brain Stem / Q000473:pathology; D004660:Encephalitis / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D005911:Gliosis; D006801:Humans; D008297:Male; D009886:Ophthalmoplegia / Q000209:etiology / Q000473:pathology; D010587:Phagocytosis; D012131:Respiratory Insufficiency / Q000209:etiology / Q000473:pathology; D013064:Speech Disorders / Q000209:etiology / Q000473:pathology