Basis of nocturnal polyuria in patients with autonomic failure.
Five dysautonomic patients with the Shy-Drager syndrome were studied to determine the basis of their nocturnal polyuria. The results indicated excessive postural modification of renal function in dysautonomic patients. This may, in fact, relate to excessive release of ADH while these patients are up and about, and excessive inhibition while they are recumbent. Treatment with vasopressin produced an inconsistent response.
D000368:Aged; D002940:Circadian Rhythm; D004402:Dysautonomia, Familial / Q000150:complications / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005242:Fecal Incontinence / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007024:Hypotension, Orthostatic / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000503:physiopathology*; D009994:Osmolar Concentration; D010300:Parkinson Disease / Q000503:physiopathology; D011187:Posture; D011188:Potassium / Q000097:blood / Q000652:urine; D012964:Sodium / Q000097:blood / Q000652:urine; D013577:Syndrome; D014549:Urinary Incontinence / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D014667:Vasopressins / Q000378:metabolism / Q000627:therapeutic use / Q000652:urine; D014868:Water Deprivation
D014667:Vasopressins; D012964:Sodium; D011188:Potassium; D006854:Hydrocortisone