Immunological sequelae of Trichinella spiralis infection in mice. II. Potentiation of cell-mediated response to BCG after infection with Trichinella spiralis.
Mice were infected with 200 Trichinella spiralis 14 days after intravenous administration of 4 x 10(6) viable BCG cells. Individual groups were tested for delayed hypersensitive footpad responses at 14, 20, 29, 57, or 85 days after T. spiralis infection. An initial suppression in the 14-day test group was observed; however, mice tested at later time intervals exhibited potentiation of the 24-h footpad reaction to old tuberculin over that elicited by appropriate controls. This suggested that T. spiralis induces a potentiation of the cellular immune response to BCG. Adoptive transfer studies support the cell-mediated nature of the observed footpad reaction and indicated that the initial suppression was not due to physiological factors preventing the expression of the footpad swelling reaction.
D000818:Animals; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007111:Immunity, Cellular; D007115:Immunization Schedule; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000166:cytology; D014234:Trichinella / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*; D014374:Tuberculin Test