5-Hydroxyindoleacetic acid in the lumbar fluid: a specific indicator of spinal cord injury.
In cats, 19 days after the lower thoracic cord was injllred, the concentrations of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid in the lumbosacral cord and that of 5-hydroxyindoleacetic acid in the lumbar fluid decreased. At the same time the concentrations of these substances in the cord above the lesion and that of 5-hydroxyindoleacetic acid in the cisternal fluid was not significantly altered. Since high concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid are present in the human lumbosacral cord, it appears that the concentration of 5-hydroxyincdoleacetic acid in the lumbar fluid of animals and man reflects the biochemical changes of 5-hydroxytryptamine in the spinal cord.
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D012701:Serotonin / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000378:metabolism; D013129:Spinal Puncture
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid