Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
1 A study is reported of the effects of phenytoin and phenobarbitone on bone calcium mobilization by parathyroid hormone in vitro.2 In a therapeutic concentration (15 mug/ml), phenytoin significantly inhibited parathyroid hormone-induced calcium release from bone.3 The inhibitory effect of phenytoin on bone calcium mobilization could play a role in the maintenance of hypocalcaemia in epileptic patients on long-term anticonvulsant drug therapy.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D003470:Culture Media; D046508:Culture Techniques; D006996:Hypocalcemia / Q000378:metabolism; D051379:Mice; D010281:Parathyroid Hormone / Q000037:antagonists & inhibitors*; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D002132:Calcium Radioisotopes; D003470:Culture Media; D010281:Parathyroid Hormone; D011506:Proteins; D010672:Phenytoin; D002118:Calcium; D010634:Phenobarbital