Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism / Q000494:pharmacology*; D001711:Biotransformation; D002250:Carbon Radioisotopes; D056486:Chemical and Drug Induced Liver Injury; D003545:Cysteine / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005978:Glutathione / Q000378:metabolism*; D006842:Hydrocarbons, Brominated / Q000378:metabolism / Q000494:pharmacology; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008862:Microsomes, Liver / Q000378:metabolism*; D009336:Necrosis / Q000139:chemically induced*; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats
D001555:Benzene Derivatives; D002250:Carbon Radioisotopes; D006842:Hydrocarbons, Brominated; D008298:Maleates; D011335:Proadifen; D005978:Glutathione; D003545:Cysteine; D010634:Phenobarbital