Lysosomal and microsomal glucuronidase: genetic variant alters electrophoretic mobility of both hydrolases.
An electrophoretic variant of beta-glucuronidase is present in certain inbred mouse lines. The variant simultaneously affects the mobility of the lysosomal and microsomal forms of the enzyme. The difference is inherited as a single gene mapping at the position of the structural gene on chromosome 5. This confirms that beta-glucuronidase at both intracellular sites is coded by the same structural gene.
D000818:Animals; D002874:Chromosome Mapping; D004592:Electrophoresis, Starch Gel; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D014644:Genetic Variation; D005838:Genotype; D005966:Glucuronidase / Q000032:analysis / Q000096:biosynthesis*; D007527:Isoenzymes / Q000032:analysis / Q000096:biosynthesis*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D009154:Mutation; D010641:Phenotype; D014176:Protein Biosynthesis; D011995:Recombination, Genetic
D007527:Isoenzymes; D005966:Glucuronidase