title: Peptic ulcer disease: a clinical study in 73 children.
abstract: Seventy-three children with peptic ulcer have been admitted to The Montreal Children's Hospital and l'Hôpital Sainte-Justine over the past 11 years. The primary ulcer group comprised 39 duodenal and nine gastric ulcers; repeat contrast studies were necessary to demonstrate a crater in 25%. Vomiting was especially prominent in the younger patients (1 month to 6 years). Pain was present in the majority of older patients (6 to 18 years) but was considered "typical" in no more than one third. Bleeding occurred more commonly in the older children but five had occult bleeding only. There was a positive family history in 11 children with primary duodenal ulcers but in none of those with gastric ulcers. Follow-up in 34 cases with primary ulcers showed that close to two thirds of the older children have had recurrent problems. Bleeding and/or perforation was the most common mode of presentation in 25 cases of secondary ulcers. Corticosteroids and increased intracranial pressure were the most frequently associated factors, the younger age group being at greater risk.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003345:Corticosterone / Q000627:therapeutic use; D004381:Duodenal Ulcer / Q000000981:diagnostic imaging / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006396:Hematemesis / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007427:Intracranial Pressure; D008297:Male; D008551:Melena / Q000175:diagnosis; D010437:Peptic Ulcer / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D010439:Peptic Ulcer Perforation / Q000601:surgery; D011859:Radiography; D012008:Recurrence; D013275:Stomach Rupture / Q000601:surgery; D013276:Stomach Ulcer / Q000000981:diagnostic imaging; D014839:Vomiting / Q000175:diagnosis
chemical_list: D003345:Corticosterone