Twitch potentiation by potassium contractures in single muscle fibres of the frog.
1. The modifications of isometric twitches after K contractures have been studied in single muscle fibres from frog muscles.2. The twitch was greatly enhanced and somewhat prolonged after a conditioning K contracture. This potentiating effect was more evident in fibres having low values of the ratio control twitch tension/tetanus tension (P/P(0)).3. In most of the fibres, the time course of the decay of the potentiation phenomenon could be represented by the sum of three negative exponentials with average half-times of 9.1, 40 and 485 sec.4. Between 3 and 10 min after the onset of the twitch potentiation the resting potential and action potential were unchanged.5. Mn blocked the K contractures and prevented the onset of the twitch potentiation.6. 40-140 sec after inducing a K contracture with 30 or 40 mM-K, a second exposure to the same [K] evoked a tension equivalent only to 57% of the first one. This partial refractoriness of the fibres is not seen when both contractures were elicited with 190 mM-K, and contrasts with the full recovery and potentiation of the twitch after a K contracture.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D003286:Contracture / Q000503:physiopathology; D004558:Electric Stimulation; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials; D009119:Muscle Contraction / Q000187:drug effects; D009210:Myofibrils / Q000502:physiology*; D011188:Potassium / Q000037:antagonists & inhibitors / Q000502:physiology*; D013997:Time Factors
D008345:Manganese; D011188:Potassium