Iatrogenic osteomalacia and myopathy due to phosphate depletion.
In a patient receiving regular dialysis prolonged hypophosphataemia due to aluminium hydroxide therapy resulted in osteomalacia and severe proximal myopathy. Both osteomalacia and myopathy responded to correction of hypophosphataemia without vitamin D therapy.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000536:Aluminum Hydroxide / Q000009:adverse effects; D002118:Calcium / Q000097:blood; D004032:Diet; D005260:Female; D006801:Humans; D009135:Muscular Diseases / Q000139:chemically induced / Q000209:etiology*; D010018:Osteomalacia / Q000139:chemically induced / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood* / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects; D014807:Vitamin D
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D000536:Aluminum Hydroxide; D000469:Alkaline Phosphatase; D002118:Calcium