title: Preparation of succinyl neocarzinostatin.
abstract: All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis-N-succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D011506:Proteins / Q000138:chemical synthesis; D012505:Sarcina / Q000187:drug effects; D013386:Succinates / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D011506:Proteins; D013386:Succinates