A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D003853:Deoxyribonucleosides / Q000378:metabolism; D003854:Deoxyribonucleotides / Q000378:metabolism; D004357:Drug Synergism; D004361:Drug Tolerance; D006150:Guanine Nucleotides / Q000378:metabolism; D006151:Guanosine / Q000378:metabolism; D007288:Inosine / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D015122:Mercaptopurine / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D009173:Mycophenolic Acid / Q000494:pharmacology; D012334:RNA, Neoplasm / Q000378:metabolism; D012265:Ribonucleotides / Q000378:metabolism; D013268:Stimulation, Chemical; D013440:Sulfides / Q000494:pharmacology; D013462:Sulfur Radioisotopes; D013866:Thioguanine / Q000378:metabolism
D000963:Antimetabolites; D004273:DNA, Neoplasm; D003853:Deoxyribonucleosides; D003854:Deoxyribonucleotides; D006150:Guanine Nucleotides; D012334:RNA, Neoplasm; D012265:Ribonucleotides; D013440:Sulfides; D013462:Sulfur Radioisotopes; D006151:Guanosine; D007288:Inosine; D015122:Mercaptopurine; D013866:Thioguanine; D009173:Mycophenolic Acid