Effects of ergotamine and methysergide on blood platelet aggregation responses of migrainous subjects.
Platelet aggregation responses to 5-hydroxytryptamine (5-HT) were measured in plasma from migrainous subjects taking either methysergide maleate or ergotamine tartrate and were found to be reduced. Blood 5-HT levels of subjects free of headache were not affected by these drugs. The results support the hypothesis that methysergide and ergotamine act by occupying 5-HT uptake sites in vessel walls, leaving 5-HT molecules available to occupy receptors concerned with vasoconstriction.
D001792:Blood Platelets / Q000032:analysis; D002536:Cerebral Arteries / Q000187:drug effects; D004878:Ergotamine / Q000627:therapeutic use*; D006801:Humans; D008784:Methysergide / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000097:blood* / Q000188:drug therapy; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011955:Receptors, Drug; D012701:Serotonin / Q000097:blood*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D011955:Receptors, Drug; D014662:Vasoconstrictor Agents; D012701:Serotonin; D004878:Ergotamine; D008784:Methysergide