Effect of prolonged thiazide treatment on renal lithium clearance.
Renal lithium clearances were determined after the administration of a small test dose of lithium carbonate in 22 patients when they were on long-term treatment with thiazides and when they were not on such treatment. Thiazide administration led to a 24% reduction in the lithium clearance. Diuretic drugs should be used with caution in patients given lithium treatment, and lithium should be used with caution in patients receiving diuretic treatment.
D001539:Bendroflumethiazide / Q000494:pharmacology; D003404:Creatinine / Q000378:metabolism; D004232:Diuretics; D004347:Drug Interactions; D004487:Edema / Q000188:drug therapy; D005260:Female; D006801:Humans; D006857:Hydroflumethiazide / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007677:Kidney Function Tests; D008094:Lithium / Q000378:metabolism*; D008297:Male; D012964:Sodium / Q000652:urine; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006857:Hydroflumethiazide; D001539:Bendroflumethiazide; D008094:Lithium; D012964:Sodium; D003404:Creatinine