title: Amphetamine effects in man: paradoxical drowsiness and lowered electrical brain acitivity (CNV).
abstract: Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D003265:Contingent Negative Variation / Q000187:drug effects; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D010775:Photic Stimulation; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D003913:Dextroamphetamine