In vitro metabolism of T-2 toxin.
Incubation of T-2 toxin with the 9,000 x g supernatant fluid of both human and bovine liver homogenate resulted in conversion to a single, deacetylated product identified as HT-2 toxin. Metabolism is more rapid in human liver. HT-2 toxin was not produced when human plasma was the incubating medium nor was it produced by treatment of T-2 toxin with simulated gastric juice. T-2 toxin was stable in gastric juice for at least 1 h.
D000328:Adult; D000818:Animals; D002417:Cattle; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D010856:Columbidae; D005670:Fusarium / Q000378:metabolism*; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D009183:Mycotoxins / Q000096:biosynthesis / Q000378:metabolism* / Q000633:toxicity; D014839:Vomiting / Q000139:chemically induced
D009183:Mycotoxins