Interaction between acetohydroxamic acid and 12 antibiotics against 14 gram-negative pathogenic bacteria.
Acetohydroxamic acid (AHA) is a potent inhibitor of urease which prevents alkalinization of urine and stone formation in rats in the presence of infection caused by urease-producing bacteria. Because an antibacterial effect of AHA, and synergy between kanamycin and AHA have also been described, we studied the interaction between AHA and 12 antibiotics against 14 gram-negative bacteria. Synergy, sometimes to a striking degree, was found in 17% of interactions; however, antagonism was detected in 5%. Infecting organisms would need to be studied individually before the antibacterial effect of AHA and an antibiotic could be predicted.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004357:Drug Synergism; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011511:Proteus / Q000187:drug effects*; D014510:Urease / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D014510:Urease