title: The response of a mouse sarcoma to single and divided doses of x-rays and fast neutrons.
abstract: The response of an experimental sarcoma to single doses and two fractions of x-rays and fast neutrons has been investigated to test the hypothesis that slowly shrinking sarcomata will reoxygenate poorly and therefore will benefit more from fractionated neutron treatment than from fractionated x-ray treatment, in contrast with rapidly shrinking carcinomata. Neutrons were approximately three times more effective than x-rays, both for single doses and for two fractions given in 48 hours, when regrowth was used as a measure of response. This observation is closely similar to results previously obtained on a rat fibrosarcoma and contrasts with previous results from a mouse mammary carcinoma, and is in agreement with the hypothesis.
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000532:radiotherapy; D002460:Cell Line; D004307:Dose-Response Relationship, Radiation; D005354:Fibrosarcoma / Q000532:radiotherapy; D006931:Hyperbaric Oxygenation; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009502:Neutrons; D010101:Oxygen Consumption; D011830:Radiation Effects; D011879:Radiotherapy Dosage; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D013997:Time Factors