Effect of naloxone on the analgesic activity of methadone in a 1:10 oral combination. Time and cost of flirting with the null hypothesis in tests of equivalence.
D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008691:Methadone / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009270:Naloxone / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D012890:Sleep / Q000187:drug effects; D013223:Statistics as Topic; D013997:Time Factors
D000700:Analgesics; D006993:Hypnotics and Sedatives; D009270:Naloxone; D008691:Methadone