title: Effect of phenobarbital and 3-methylcholanthrene administration in vivo and isooctane extraction in vitro on metyrapone binding to reduced cytochrome P-450.
mesh_terms: D000473:Alkanes / Q000494:pharmacology*; D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008748:Methylcholanthrene / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008797:Metyrapone / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D000473:Alkanes; D012997:Solvents; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D003513:Cycloheximide; D010634:Phenobarbital; D008797:Metyrapone