title: Synthesis and antiestrogenic activity of 2,4-bis(bromomethyl)-estrone methyl ether: a bifunctional alkylating steroid.
mesh_terms: D000818:Animals; D001565:Benzoates; D001665:Binding Sites; D001681:Biological Assay; D001966:Bromine / Q000378:metabolism / Q000494:pharmacology; D002250:Carbon Radioisotopes; D002369:Castration; D002855:Chromatography, Thin Layer; D003545:Cysteine; D004962:Estranes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004965:Estrogen Antagonists; D004970:Estrone / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006639:Histidine; D009682:Magnetic Resonance Spectroscopy; D008623:Mercaptoethanol; D000432:Methanol; D008738:Methyl Ethers / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D009574:Nitro Compounds; D010053:Ovary / Q000502:physiology; D051381:Rats; D013438:Sulfhydryl Compounds; D014364:Tryptophan; D014599:Uterus / Q000201:enzymology
chemical_list: D001565:Benzoates; D002250:Carbon Radioisotopes; D004962:Estranes; D004965:Estrogen Antagonists; D008738:Methyl Ethers; D009574:Nitro Compounds; D013438:Sulfhydryl Compounds; D004970:Estrone; D006639:Histidine; D008623:Mercaptoethanol; D014364:Tryptophan; D005954:Glucosephosphate Dehydrogenase; D003545:Cysteine; D001966:Bromine; D000432:Methanol