Amphetamine effects in man: paradoxical drowsiness and lowered electrical brain acitivity (CNV).
Thirteen of 20 normal adults given 10 milligrams of dextroamphetamine exhibited paradoxical drowsiness accompanied by lowered electrical brain activity (contingent negative variation, or CNV) in the first hour post-drug. During this period, seven subjects showed behavioral alertness and increased CNV amplitude. Both groups of subjects showed heightened alertness 2 and 3 hours post-drug. Amphetamine is not a simple stimulant of the central nervous system but can also act as a depressant.
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D003265:Contingent Negative Variation / Q000187:drug effects; D003864:Depression, Chemical; D003913:Dextroamphetamine / Q000494:pharmacology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D010775:Photic Stimulation; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
D003913:Dextroamphetamine