title: Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003580:Cytochromes / Q000378:metabolism; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006418:Heme / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008777:Methyltestosterone / Q000494:pharmacology; D051379:Mice; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism; D011284:Pregnenolone / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D013148:Spironolactone / Q000008:administration & dosage / Q000494:pharmacology*; D013250:Steroid Hydroxylases / Q000378:metabolism; D013737:Testis / Q000166:cytology / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis* / Q000494:pharmacology
chemical_list: D002250:Carbon Radioisotopes; D003580:Cytochromes; D013148:Spironolactone; D013739:Testosterone; D006418:Heme; D011374:Progesterone; D011284:Pregnenolone; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D008777:Methyltestosterone