Interaction between piperazine and chlorpromazine.
The interaction between piperazine and chlorpromazine has been studied in rats and mice. Piperazine administered a few hours previously potentiated the action of chlorpromazine on the central nervous system. No such interaction was found between piperazine and prochlorperazine.
D000818:Animals; D002389:Catatonia / Q000187:drug effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000633:toxicity*; D004347:Drug Interactions; D004357:Drug Synergism; D004569:Electroencephalography; D005260:Female; D006801:Humans; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage / Q000633:toxicity*; D011346:Prochlorperazine / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats
D010879:Piperazines; D002746:Chlorpromazine; D011346:Prochlorperazine