Effects of postnatal influences on conditioning and some functional and structural brain parameters in rats.
Early postnatal influences were studied in rats in three different ways: (i) different litter size, (ii) feeding with restricted amount of protein, (iii) different level of afferent stimulation. A complex evaluation of spontaneous activity, conditioning, electrophysiological and biochemical analyses was used in these experiments. Medium sized litters showed the greater electrophysiological reactivity (cortical evoked potentials) and the most stable performance in different kinds of conditioning (avoidance) experiments. Animals reared on a low protein diet were subnormal in electrophysiological indices, and had a lower level of biochemical activity for materials Involved in neural excitability, electrogenesis, and cellular and subcellular energetic metabolism (phospholipids, proteins, DNA, RNA). In all respects (behavioral, electrophysiological and biochemical tests) animals with partial sensory deprivation in the postnatal period had the lowest indices. The "stimulated" animals on the other hand were superior to both other groups in the tests used for the analysis of higher nervous activity, but electrophysiological and biochemical analyses did not show clear differences between the "stimulated" and control animals. Optimal development of brain functions requires adequate conditions in the early postnatal period. However, the "adequacy" of them conditions has dill to be determined more precisely.
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000502:physiology*; D004044:Dietary Proteins; D005071:Evoked Potentials; D005260:Female; D005298:Fertility; D008297:Male; D012683:Sensory Deprivation
D004044:Dietary Proteins