title: Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis.
abstract: Mean homovanillic acid and 5-hydroxyindoleacetic acid concentrations were significantly low in the lumbar CSF of a group of patients with disseminated sclerosis (DS) who were severely disabled but not in the CSF of a less severely restricted group with DS. CSF concentrations were also low in a group of patients with superior cerebellar peduncular tremor due to DS and in a single patient with a similar tremor associated with a post-traumatic brain-stem lesion. The interpretation of abnormal CSF amine metabolite concentrations is discussed in the light of these findings.
mesh_terms: D002526:Cerebellar Diseases / Q000134:cerebrospinal fluid / Q000209:etiology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000150:complications; D010648:Phenylacetates / Q000134:cerebrospinal fluid*; D014202:Tremor / Q000134:cerebrospinal fluid / Q000209:etiology
chemical_list: D010648:Phenylacetates; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid