Linkage between reproductive capacity at increased temperature and neurotropic activity in A-NWS HONi (HON1) influenza virus.
We investigated the rate of covariation between the ability of the NWS strain of influenza virus to reproduce at increased temperature and its neurotropic properties. Results indicated that increased growth at 39 C was related to increased neurovirulence, and acquisition of the temperature-sensitive character was related to loss of neurovirulence.
D000818:Animals; D004660:Encephalitis / Q000276:immunology; D051379:Mice; D009975:Orthomyxoviridae; D013696:Temperature; D014774:Virulence; D014779:Virus Replication