Gelation of sickle cell hemoglobin: effects of hybrid tetramer formation in hemoglobin mixtures.
The altered gelation behavior found in mixtures of sickle cell hemoglobin with other hemoglobins is due to the formation of hybrid hemoglobin tetramers from unlike dimers. The hemoglobins need not possess the deoxy quaternary structure for gelation to occur; liganded forms are also capable of participation in gelation.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005782:Gels; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D006801:Humans; D007700:Kinetics; D008024:Ligands; D011108:Polymers; D011487:Protein Conformation
D005782:Gels; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D008024:Ligands; D011108:Polymers