Lysergic acid diethylamide: sensitive neuronal units in the midbrain raphe.
Units in areas of the midbrain rich in neurons containing serotonin respond to parenteral injections of d-lysergic acid diethylamide by a reversible cessation of spontaneous activity. The dose required is at or below threshold for gross behavioral effects. An inhibition of neurons containing serotonin after administration of d-lysergic acid diethylamide could account for the decreased metabolism of serotonin produced by this drug.
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D005246:Feedback; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013238:Stereotaxic Techniques
D012701:Serotonin; D008238:Lysergic Acid Diethylamide