Human C'3: evidence for the liver as the primary site of synthesis.
The liver is the primary, if not sole, site of synthesis of the third component of human complement, as shown by a change in the recipient from C'3 FS(0.6) to C'3 SS, the donor type, following homotransplantation of the liver.
D000293:Adolescent; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001379:Azathioprine / Q000494:pharmacology; D001797:Blood Protein Electrophoresis; D002648:Child; D003165:Complement System Proteins / Q000096:biosynthesis*; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000378:metabolism; D016031:Liver Transplantation; D008297:Male; D008967:Molecular Biology; D011110:Polymorphism, Genetic; D011241:Prednisone / Q000494:pharmacology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D006242:Haptoglobins; D003165:Complement System Proteins; D001379:Azathioprine; D011241:Prednisone