title: Cycasin: detection of associated mutagenic activity in vivo.
abstract: Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.
mesh_terms: D000818:Animals; D007422:Intestines / Q000382:microbiology; D008297:Male; D051379:Mice; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012486:Salmonella typhimurium
chemical_list: D009153:Mutagens