title: In vitro activity of carbenicillin against gram-negative bacilli.
abstract: The activity of a new semisynthetic penicillin, carbenicillin, was determined against 241 strains of gram-negative bacilli with the tube-dilution technique. Of 143 strains of Pseudomonas sp., 99 had a minimal inhibitory concentration of 200 to 300 mug/ml. The majority of strains of Escherichia coli and Proteus spp. were sensitive to this antibiotic, with minimal inhibitory concentrations of 25 mug/ml or less. Strains of Klebsiella sp. were quite resistant to carbenicillin. The size of inoculum had no significant effect on the minimal inhibitory concentration for Pseudomonas sp.
mesh_terms: D001769:Blood / Q000382:microbiology; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007709:Klebsiella / Q000187:drug effects*; D010406:Penicillins / Q000494:pharmacology*; D010614:Pharynx / Q000382:microbiology; D011511:Proteus / Q000187:drug effects*; D011549:Pseudomonas / Q000187:drug effects*; D012705:Serratia / Q000187:drug effects; D013183:Sputum / Q000382:microbiology; D014556:Urine / Q000382:microbiology; D014947:Wounds and Injuries / Q000382:microbiology
chemical_list: D010406:Penicillins