title: Genetic map position of the gluconate-6-phosphate dehydrogenase gene in Salmonella typhimurium.
abstract: Gluconate-6-phosphate dehydrogenase (GND) is genetically determined in Salmonella typhimurium by a locus (gnd) mapping between the somatic antigen (rfb) and histidine (his) operons. The enzyme is constitutive. Strains of Salmonella carrying an F' genetic element which contains the gnd(+) gene have GND activity two to three times that of the wild type. This gene dosage effect was used to determine that the GND reaction is not rate-limiting for the metabolism of glucose by the pentose shunt in S. typhimurium.
mesh_terms: D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D003227:Conjugation, Genetic; D004926:Escherichia coli / Q000201:enzymology; D005111:Extrachromosomal Inheritance; D005827:Genetics, Microbial; D005947:Glucose / Q000378:metabolism; D008967:Molecular Biology; D009154:Mutation; D010734:Phosphogluconate Dehydrogenase; D012486:Salmonella typhimurium / Q000378:metabolism; D014161:Transduction, Genetic
chemical_list: D010734:Phosphogluconate Dehydrogenase; D005947:Glucose