2,5-dimethoxy-4-methyl-amphetamine (STP): a new hallucinogenic drug.
We have assessed the effects in normal control volunteers of 2,5-dimethoxy-4-methyl-amphetamine, the chemical present in the hallucinogenic drug STP, in two independent trials. In low doses, this compound produces a mild euphoria. Doses greater than 3 milligrams may cause pronounced hallucinogenic effects lasting about 8 hours and similar to those produced by hallucinogenic doses of lysergic acid diethylamide, mescaline, and psilocybin. 2,5-Dimethoxy-4-methyl-amphetamine, which is chemically related to mescaline and amphetamine, is about 100 times more potent as a hallucinogen than mescaline and only one-thirtieth as potent as lysergic acid diethylamide. Its psychological effects are not accentuated by chlorpromazine.
D000328:Adult; D000661:Amphetamine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D002986:Clinical Trials as Topic; D005059:Euphoria / Q000139:chemically induced; D006212:Hallucinations / Q000139:chemically induced; D006213:Hallucinogens / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D010465:Perception / Q000187:drug effects; D011562:Psilocybin / Q000494:pharmacology; D011600:Psychopharmacology; D011680:Pupil / Q000187:drug effects
D002395:Catecholamines; D006213:Hallucinogens; D011562:Psilocybin; D008238:Lysergic Acid Diethylamide; D000661:Amphetamine; D008635:Mescaline; D002746:Chlorpromazine