Experimental studies on the development of the thymus.
Experiments utilizing chromosome marker and histological techniques in combination with parabiosis and transplanatation procedures have demonstrated an inflow of blood-home stem cells into the chick embryo thymic rudiment. There is close similarity between the histological picture in the chick and in the mouse thymic rudiment, and it is proposed that a similar developmental process takes place in both. It may be concluded that the epithelial component of the thymic rudiment, rather than producing lymphoid cells itself, furnishes an inductive environment for the proliferation and differentiation of stem cells derived extrinsically.
D000818:Animals; D002060:Bursa of Fabricius / Q000166:cytology / Q000196:embryology; D002454:Cell Differentiation; D002642:Chick Embryo; D002874:Chromosome Mapping; D004847:Epithelial Cells; D005321:Extraembryonic Membranes / Q000166:cytology; D005260:Female; D006410:Hematopoiesis; D006652:Histological Techniques; D008221:Lymphoid Tissue / Q000502:physiology; D008297:Male; D051379:Mice; D009030:Mosaicism; D010227:Parabiosis; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology* / Q000276:immunology / Q000637:transplantation; D014184:Transplantation, Homologous