Hemophilia: role of organ homografts.
The concentration of factor VIII and partial thromboplastin times became normal and have remained normal for 140 days after orthotopic tranplantation of a normal liver to a hemophilic dog. Transplantation of a normal spleen into a hemophilic recipient did not result in a significant increase in factor VIII although the splenic graft was viable for at least 47 days. Transplantation of normal marrow to a lethally irradiated hemophilic dog did not result in an increase in factor VIII during 34 days of observation.
D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D001780:Blood Coagulation Tests; D016026:Bone Marrow Transplantation; D004285:Dogs; D005169:Factor VIII / Q000096:biosynthesis*; D006467:Hemophilia A / Q000378:metabolism*; D016031:Liver Transplantation; D008775:Methylprednisolone / Q000494:pharmacology; D010227:Parabiosis; D011833:Radiation Injuries, Experimental; D011877:Radionuclide Imaging; D013154:Spleen / Q000637:transplantation*; D013667:Technetium; D013925:Thromboplastin / Q000096:biosynthesis; D014184:Transplantation, Homologous
D013667:Technetium; D005169:Factor VIII; D013925:Thromboplastin; D001379:Azathioprine; D008775:Methylprednisolone