Clinical trial of 6 per cent hydroxyethyl starch (a new plasma expander).
No adverse effects were seen in 29 patients given an intravenous infusion of 6% hydroxyethyl starch solution. Platelet counts had fallen by eight hours after infusion, but had reached pretransfusion levels by 24 hours. Two patients developed unusual bleeding post-operatively, which was possibly due to the infusion. Further investigations on the first stage of coagulation and prothrombin generation in patients receiving hydroxyethyl starch are required.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets; D002986:Clinical Trials as Topic; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D011183:Postoperative Complications; D011516:Prothrombin / Q000096:biosynthesis; D013213:Starch / Q000494:pharmacology / Q000627:therapeutic use*
D010952:Plasma Substitutes; D011516:Prothrombin; D013213:Starch