Regulation of food intake and obesity.
This is not the place to consider the medical significance of obesity in terms of conditions such as heart disease and hypertension, diabetes, and arthritis. These very complex interrelationships have been dealt with elsewhere (69). We hope that enough evidence has been presented to demonstrate that energy balance is normally maintained by a precise and reliable physiologic mechanism, and that the energy surplus represented by obesity may reflect direct failure of this mechanism or some combination from a variety of neurological, endocrine, enzymatic, and psychological disorders. Environmental conditions as well as genetic and traumatic factors may contribute to the development of obesity. If increasing mechanization brings tus below the level of energy expenditure at which food intake is properly regulated, appropriate habits of exercise will have to be established and maintained.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002628:Chemoreceptor Cells / Q000502:physiology; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders; D005769:Gastrointestinal Motility; D005947:Glucose / Q000378:metabolism; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient; D006801:Humans; D006815:Hunger; D006943:Hyperglycemia / Q000235:genetics; D007027:Hypothalamic Diseases / Q000209:etiology; D007031:Hypothalamus / Q000503:physiopathology; D007515:Islets of Langerhans / Q000503:physiopathology; D051379:Mice; D009765:Obesity / Q000209:etiology* / Q000235:genetics; D010770:Phosphotransferases / Q000378:metabolism; D005082:Physical Exertion; D012923:Social Class
D010770:Phosphotransferases; D005947:Glucose