Rejection of renal allografts: specific immunologic suppression.
Kidneys were transplanted across a major genetic barrier (Ag-B locus), from LewisxBN F(1) hybrid rats into bilaterally nephrectomized Lewis rats. Survival of grafts is prolonged (indefinite?) in rats treated with a combination of (i) intravenous injection of donor spleen cells 1 day before the graft, and (ii) passive immunization with antiserum prepared in rats of the recipient strain against donor spleen and lymph-node cells. The recipient's immune response to other antigens is not impaired.
D000818:Animals; D000941:Antigens; D001806:Blood Urea Nitrogen; D005823:Genetics; D006824:Hybridization, Genetic; D006968:Hypersensitivity, Delayed; D007106:Immune Sera; D007112:Immunity, Maternally-Acquired; D007166:Immunosuppressive Agents; D007518:Isoantibodies; D016030:Kidney Transplantation; D008198:Lymph Nodes / Q000276:immunology*; D009026:Mortality; D009392:Nephrectomy; D010567:Pertussis Vaccine; D051381:Rats; D013154:Spleen / Q000276:immunology*; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000941:Antigens; D007106:Immune Sera; D007166:Immunosuppressive Agents; D007518:Isoantibodies; D010567:Pertussis Vaccine