Isolation and characterization of antibiotic LL-AC541.
A new basic, water-soluble antibiotic designated LL-AC541, produced by a strain of Streptomyces hygroscopicus (NRRL 3111), was isolated as a hydrochloride salt; [alpha](D) (25), - 58 degrees , melting point, 200 to 215 C (decomposition). It is structurally related to streptothricin but does not contain beta-lysine. Isolation procedures, physicochemical properties, antimicrobial spectrum, and in vivo testing results are presented. Another very closely related antibiotic obtained from the same fermentation is briefly described.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002623:Chemistry Techniques, Analytical; D002627:Chemistry, Physical; D002852:Chromatography, Ion Exchange; D004586:Electrophoresis; D004927:Escherichia coli Infections / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013053:Spectrophotometry; D013203:Staphylococcal Infections / Q000188:drug therapy; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents