Reversal of morphine tolerance after medial thalamic lesions in the rat.
Tolerance, manifested by a diminished electroencephalographic response at cortical and subcortical recording sites, was found in rats subjected to repeated systemic injections of morphine sulfate. Reversal of tolerance to morphine resulted from destruction of the medial thalamus.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance / Q000187:drug effects*; D004569:Electroencephalography; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013375:Substance Withdrawal Syndrome; D013788:Thalamus / Q000187:drug effects / Q000502:physiology*
D009270:Naloxone; D009020:Morphine