Escherichia coli: high resistance or dependence on streptomycin produced by the same allele.
Mutations to streptomycin resistance in Escherichia coli K12, when transferred to a C strain, can confer dependence on streptomycin. These alternatives in expression of the allele are probably a result of interaction between two ribosomal proteins.
D000483:Alleles; D001426:Bacterial Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000378:metabolism*; D005827:Genetics, Microbial; D009154:Mutation; D010597:Pharmacogenetics; D011995:Recombination, Genetic; D012270:Ribosomes / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology*; D014161:Transduction, Genetic
D001426:Bacterial Proteins; D013307:Streptomycin