Erythromycin-resistant mutant of Escherichia coli with altered ribosomal protein component.
Erythromycin combines with 50S ribosomal subunit of an erythromycin-sensitive Escherichia coli (strain Q13), while ribosomes from an erythromycin-resistant mutant from this strain have little affinity for the antibiotic. A protein component of the 50S subunit of the mutant strain is distinct from that of the parent Q13 strain.
D001426:Bacterial Proteins / Q000032:analysis*; D002247:Carbon Isotopes; D002474:Cell-Free System; D002852:Chromatography, Ion Exchange; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000378:metabolism*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D005827:Genetics, Microbial; D008239:Lysine; D008747:Methylcellulose; D009154:Mutation; D010597:Pharmacogenetics; D011485:Protein Binding; D012270:Ribosomes / Q000378:metabolism*; D014316:Tritium; D014364:Tryptophan
D001426:Bacterial Proteins; D002247:Carbon Isotopes; D014316:Tritium; D004917:Erythromycin; D014364:Tryptophan; D008747:Methylcellulose; D008239:Lysine