The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice.
1. The influence of some intracerebroventricularly administered sympathomimetic amines on leptazol-induced convulsions has been investigated.2. Noradnamine and high doses of dopamine proved to be anticonvulsant and also antagonized the facilitative effects of reserpine.3. Noradrenaline and octopamine also antagonized reserpine-induced facilitation but were without effect on leptazol alone; by contrast tyramine and small doses of dopamine lowered the threshold for leptazol convulsions.4. A possible interpretation of these results is presented.
D000818:Animals; D002552:Cerebral Ventricles; D003986:Dibenzocycloheptenes / Q000627:therapeutic use*; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use; D007267:Injections; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000494:pharmacology; D009655:Octopamine / Q000494:pharmacology; D010433:Pentylenetetrazole; D012110:Reserpine / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D013566:Sympathomimetics / Q000627:therapeutic use*; D014439:Tyramine / Q000494:pharmacology
D003986:Dibenzocycloheptenes; D013566:Sympathomimetics; D009655:Octopamine; D012110:Reserpine; D004298:Dopamine; D010433:Pentylenetetrazole; D009638:Norepinephrine; D014439:Tyramine