Antimicrobial evaluation of 1-methyl-3-nitro-1-Nitrosoguanidine.
1-Methyl-3-nitro-1-nitrosoguanidine was shown to have in vitro antimicrobial activity against fungi and gram-positive and gram-negative bacteria; it was also shown to have in vivo activity in mice experimentally infected with Staphylococcus aureus or Escherichia coli comparable to that observed with penicillin or streptomycin sulfate.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D009603:Nitroso Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D006146:Guanidines; D009603:Nitroso Compounds