title: Suppressor selectrion for amino acid replacements expected on the basis of the genetic code.
abstract: In studies with A protein mutants of the tryptophan synthetase of Escherichia coli, missense supressors have been used to select for codon changes and corresponding amino acid replacements that are normally unobservable. The technique has permitted the detection of additional amino acid replacements expected on the basis of the genetic code.
mesh_terms: D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D001216:Asparagine / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis*; D004926:Escherichia coli / Q000378:metabolism*; D005796:Genes; D005815:Genetic Code; D005827:Genetics, Microbial; D005971:Glutamates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D006836:Hydro-Lyases / Q000096:biosynthesis*; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D009154:Mutation; D009711:Nucleotides / Q000378:metabolism*; D010649:Phenylalanine / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D013489:Suppression, Genetic; D013912:Threonine / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D005971:Glutamates; D009711:Nucleotides; D012333:RNA, Messenger; D007532:Isoleucine; D013912:Threonine; D001224:Aspartic Acid; D014443:Tyrosine; D012694:Serine; D010649:Phenylalanine; D006639:Histidine; D001216:Asparagine; D001120:Arginine; D008715:Methionine; D006836:Hydro-Lyases; D007930:Leucine; D014633:Valine; D008239:Lysine; D000409:Alanine; D005998:Glycine