Immunologic defenses against metastases: impairment by excision of an allotransplanted lymphoma.
Hamsters grafted with an allotransplantable lymphoma that does not metastasize develop a state of concomitant immunity which renders them refractory to reinoculation with cells of the same tumor. Removal of the tumor 7 days after transplantation rapidly leads to a decrease in immunity, the production of enhancing antibodies, and the appearance of metastatic deposits which are probably derived from preexisting tumor cells in the blood and lymphoid tissuces.
D000818:Animals; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D007178:Inbreeding; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology* / Q000601:surgery; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000276:immunology*; D009368:Neoplasm Transplantation; D010537:Peritoneum / Q000166:cytology; D012513:Sarcoma, Experimental; D013154:Spleen / Q000166:cytology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous