title: Placental permeability of lead.
abstract: The detection of lead in fetal tissues by chemical analysis has long been accepted as prima facie evidence for the permeability of the placenta to this nonessential trace metal. However, only a few investigations, all on lower mammalian species, have contributed any direct experimental data bearing on this physiological process. Recent radioactive tracer and radioautographic studies on rodents have shown that lead crosses the placental membranes rapidly and in significant amounts even at relatively low maternal blood levels. While it is not possible to extrapolate directly the results of these experiments to humans because of differences in placental structure and other factors, the results do serve as a warning of the possible hazard to the human embryo and fetus of even low levels of lead in the maternal system.
mesh_terms: D000022:Abortion, Spontaneous / Q000139:chemically induced; D000818:Animals; D001345:Autoradiography; D001769:Blood; D002463:Cell Membrane Permeability; D006224:Cricetinae; D004622:Embryo, Mammalian / Q000187:drug effects; D004781:Environmental Exposure; D005260:Female; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D007854:Lead / Q000097:blood / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D051379:Mice; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011868:Radioisotopes; D051381:Rats; D014470:Umbilical Cord
chemical_list: D011868:Radioisotopes; D007854:Lead