title: Effects of streptomycin deprivation on enzyme synthesis in streptomycin-dependent Escherichia coli.
abstract: During growth of streptomycin-dependent strains of Escherichia coli in the absence of streptomycin (deprived growth), both constitutive and inducible synthesis of beta-galactosidase were preferentially inhibited. A similar preferential inhibition of constitutive and derepressed synthesis of alkaline phosphatase was observed. Catabolite repression accounted for part, but not all, of the inhibition of the inducible beta-galactosidase synthesis. Serological experiments indicated that that part of the inhibition specificially associated with streptomycin deprivation was not a result of the production of altered beta-galactosidase. It is suggested that during deprived growth the ribosomes of streptomycin-dependent bacteria become impaired in their ability to translate certain messages.
mesh_terms: D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D002247:Carbon Isotopes; D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D005696:Galactosidases / Q000096:biosynthesis* / Q000378:metabolism; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects; D013307:Streptomycin / Q000378:metabolism / Q000494:pharmacology*; D014170:Transformation, Genetic
chemical_list: D002247:Carbon Isotopes; D003470:Culture Media; D010649:Phenylalanine; D000469:Alkaline Phosphatase; D005696:Galactosidases; D013307:Streptomycin