Function of the glyoxylate-condensing enzymes. I. Growth of Escherichia coli on n-valeric acid.
Growth of Escherichia coli E-26 on valeric acid results in the formation of a mutant population characterized by the ability to form constitutively several glyoxylate-condensing enzymes. This mutant also differs from the parent organism in the ability to effect rapid growth on a series of short-chain fatty acids. These mutants were utilized in postulating genetic relationships among the various glyoxylate-condensing activities and also in correlating the presence of these enzymes with the ability of the mutants to initiate growth quickly on short-chain fatty acids.
D000085:Acetates / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism; D002208:Caproates / Q000378:metabolism; D002247:Carbon Isotopes; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000201:enzymology / Q000254:growth & development*; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006038:Glyoxylates; D008190:Lyases / Q000096:biosynthesis* / Q000378:metabolism / Q000494:pharmacology; D009154:Mutation / Q000187:drug effects; D011422:Propionates / Q000378:metabolism; D014631:Valerates / Q000378:metabolism*
D000085:Acetates; D002087:Butyrates; D002208:Caproates; D002247:Carbon Isotopes; D005227:Fatty Acids; D006038:Glyoxylates; D011422:Propionates; D014631:Valerates; D008190:Lyases; D005947:Glucose