title: Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury.
abstract: The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism.
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002460:Cell Line; D002470:Cell Survival; D002478:Cells, Cultured; D006863:Hydrogen-Ion Concentration; D007672:Kidney Cortex / Q000166:cytology / Q000378:metabolism; D010100:Oxygen; D011188:Potassium / Q000378:metabolism; D013997:Time Factors
chemical_list: D011188:Potassium; D010100:Oxygen