2-Deoxyribose gene-enzyme complex in Salmonella typhimurium: regulation of phosphodeoxyribomutase.
Phosphodeoxyribomutase, the enzyme which catalyzes the interconversion of 2-deoxyribose-1-phosphate to 2-deoxyribose-5-phosphate, has been partially purified from Salmonella typhimurium. The enzyme had an absolute requirement for manganese ion and was stimulated by glucose-1, 6-diphosphate. Phosphodeoxyribomutase was induced by deoxyribose-5-phosphate and was coordinately regulated with the enzymes thymidine phosphorylase and deoxyribose-5-phosphate aldolase, type II. Mutants deficient in these three enzymes were isolated and mapped close to the threonine locus in S. typhimurium. The three enzymes thymidine phosphorylase, deoxyribose-5-phosphate aldolase, type II, and phosphodeoxyribomutase are controlled by a series of linked genes and appear to constitute an operon.
D000446:Aldehyde-Lyases / Q000378:metabolism; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D003227:Conjugation, Genetic; D004790:Enzyme Induction; D006600:Hexosephosphates / Q000494:pharmacology; D007535:Isomerases / Q000302:isolation & purification / Q000378:metabolism*; D008345:Manganese / Q000494:pharmacology; D008967:Molecular Biology; D009154:Mutation; D009876:Operon; D010428:Pentosephosphates / Q000378:metabolism / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000201:enzymology*; D012492:Salts / Q000494:pharmacology; D013936:Thymidine; D014166:Transferases / Q000378:metabolism
D006600:Hexosephosphates; D010428:Pentosephosphates; D012492:Salts; D008345:Manganese; D014166:Transferases; D000446:Aldehyde-Lyases; D007535:Isomerases; D013936:Thymidine