Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12.
Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.
D004269:DNA, Bacterial / Q000096:biosynthesis; D004790:Enzyme Induction; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D005964:Glucosyltransferases / Q000378:metabolism; D009705:Nucleosides / Q000494:pharmacology*; D009713:Nucleotidyltransferases / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism*; D014316:Tritium
D004269:DNA, Bacterial; D009705:Nucleosides; D014316:Tritium; D005964:Glucosyltransferases; D009713:Nucleotidyltransferases; D013936:Thymidine