Hypotension caused by L-dopa.
In 20 patients with idiopathic Parkinsonism maximum tolerated doses of L-dopa were found to induce a mean reduction in blood pressure (erect systolic) of 19.3 mm.Hg, without any significant change in pulse rate. This hypotension may be due to dopamine, acting on adrenergic nerve endings or on the central nervous system itself.
D002490:Central Nervous System / Q000187:drug effects; D002986:Clinical Trials as Topic; D004295:Dihydroxyphenylalanine / Q000009:adverse effects*; D004298:Dopamine / Q000494:pharmacology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D009411:Nerve Endings / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy; D010919:Placebos; D011187:Posture; D011674:Pulse; D013237:Stereoisomerism; D013564:Sympathetic Nervous System / Q000187:drug effects
D010919:Placebos; D004295:Dihydroxyphenylalanine; D004298:Dopamine