Biological properties of cell wall mucopeptide of hemolytic streptococci.
Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 microg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction. Intravenous injection of 80 microg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells.
D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis*; D002241:Carbohydrates / Q000032:analysis; D002473:Cell Wall / Q000032:analysis*; D003348:Cortisone / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli / Q000276:immunology; D005334:Fever / Q000188:drug therapy; D008070:Lipopolysaccharides / Q000032:analysis / Q000494:pharmacology; D009088:Mucoproteins / Q000032:analysis* / Q000302:isolation & purification / Q000633:toxicity; D009205:Myocarditis / Q000139:chemically induced; D009206:Myocardium / Q000473:pathology; D009500:Neutralization Tests; D011749:Pyrogens; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000139:chemically induced; D013297:Streptococcus pyogenes / Q000032:analysis*
D001426:Bacterial Proteins; D002241:Carbohydrates; D004731:Endotoxins; D008070:Lipopolysaccharides; D009088:Mucoproteins; D011749:Pyrogens; D003348:Cortisone