title: Kasugamycin resistance: 30S ribosomal mutation with an unusual location on the Escherichia coli chromosome.
abstract: A mutation in Escherichia coli to resistance to the aminoglycoside antibiotic kasugamycin alters the 30S ribosomal subunit. Though all other known 30S ribosomal mutations are located in a cluster in the streptomycin region, kasugamycin resistance is located at a distance from this region, near the leucine region.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002247:Carbon Isotopes; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D012270:Ribosomes; D014633:Valine / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D010649:Phenylalanine; D014633:Valine