Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.
R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.
D000606:Amino Sugars / Q000037:antagonists & inhibitors; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D005964:Glucosyltransferases / Q000378:metabolism; D006027:Glycosides / Q000037:antagonists & inhibitors; D007612:Kanamycin / Q000037:antagonists & inhibitors; D009355:Neomycin / Q000037:antagonists & inhibitors; D013307:Streptomycin / Q000037:antagonists & inhibitors
D000606:Amino Sugars; D000900:Anti-Bacterial Agents; D006027:Glycosides; D007612:Kanamycin; D005964:Glucosyltransferases; D009355:Neomycin; D013307:Streptomycin