title: Topical ampicillin in the appendicectomy wound: report of double-blind trial.
abstract: One hundred and thirty unselected patients undergoing appendicectomy were treated with topical ampicillin powder or topical placebo powder (lactose) before closing the wound. The postoperative wound infection rates were 3% in the ampicillin-treated group and 24% in the control group, a significant difference. This difference was not influenced by the degree of inflammation in the appendix. No side-effects of treatment were observed.
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage*; D001062:Appendectomy / Q000009:adverse effects; D001064:Appendicitis / Q000473:pathology; D001065:Appendix / Q000473:pathology; D002986:Clinical Trials as Topic; D006801:Humans; D007785:Lactose; D010919:Placebos; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D010919:Placebos; D000667:Ampicillin; D007785:Lactose