title: Use of vaccinia virus in the treatment of metastatic malignant melanoma.
abstract: Of 19 patients with proved metastases from malignant melanoma treated by inoculations of smallpox vaccine, intradermal deposits disappeared completely in six out of ten cases. Five of these remained well 2 to 22 months after initial treatment. The response was limited strictly to the site of inoculation. The mechanism of action of vaccinia virus in malignant melanoma is not clear.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007167:Immunotherapy; D007271:Injections, Intradermal; D008297:Male; D008545:Melanoma / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000628:therapy; D016038:Skin Transplantation; D012900:Smallpox Vaccine; D014616:Vaccinia virus
chemical_list: D012900:Smallpox Vaccine