The use of intravenous tyramine and the cold pressor test to help elucidate a possible mechanism of action of a new isoquinoline compound shown to have antihypertensive properties in humans.
D000578:Amidines / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001665:Binding Sites; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D002986:Clinical Trials as Topic; D003080:Cold Temperature; D005246:Feedback; D006801:Humans; D007101:Immersion; D007546:Isoquinolines / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism / Q000652:urine; D013564:Sympathetic Nervous System / Q000502:physiology; D014363:Tryptamines / Q000652:urine; D014439:Tyramine / Q000494:pharmacology*; D014642:Vanilmandelic Acid / Q000652:urine
D000578:Amidines; D000959:Antihypertensive Agents; D002395:Catecholamines; D007546:Isoquinolines; D014363:Tryptamines; D014642:Vanilmandelic Acid; D009638:Norepinephrine; D014439:Tyramine