Compartmentation of terpenoid biosynthesis in green plants. A proposed route of acetyl-coenzyme A synthesis in maize chloroplasts.
On the basis of radioisotope-incorporation experiments it is suggested that acetyl-CoA, an obligatory intermediate in chloroplast terpenoid biosynthesis, may be formed in maize from photosynthetically fixed carbon dioxide by the route carbon dioxide-->glycollate-->glyoxylate-->glycine-->serine-->pyruvate-->acetyl-CoA. The proposed route is supported by conventional radioisotope-dilution studies and by experiments with inhibitors affecting reactions involved in the pathway. The proposed route appears to play little part in formation of extrachloroplastidic sterol.
D002245:Carbon Dioxide / Q000378:metabolism; D002247:Carbon Isotopes; D002736:Chloroplasts / Q000378:metabolism*; D003065:Coenzyme A / Q000096:biosynthesis*; D005998:Glycine / Q000378:metabolism; D006016:Glycolates / Q000378:metabolism; D006038:Glyoxylates / Q000378:metabolism; D010788:Photosynthesis; D011773:Pyruvates / Q000378:metabolism; D011865:Radioisotope Dilution Technique; D012694:Serine / Q000378:metabolism; D013729:Terpenes / Q000096:biosynthesis*
D002247:Carbon Isotopes; D006016:Glycolates; D006038:Glyoxylates; D011773:Pyruvates; D013729:Terpenes; D002245:Carbon Dioxide; D012694:Serine; D003065:Coenzyme A; D005998:Glycine