Autoimmunization with irradiated tumour cells in human malignant melanoma.
Thirteen patients have been immunized with their own irradiated melanoma cells on one or more occasions. Following these autografts tumour-specific cytotoxic antibodies were produced, the longest response lasting 14 days. This procedure had no apparent effect on the course of the disease in these patients.
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis*; D003168:Complement Fixation Tests; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007114:Immunization; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D009368:Neoplasm Transplantation; D012334:RNA, Neoplasm / Q000096:biosynthesis; D011830:Radiation Effects; D014182:Transplantation, Autologous
D001323:Autoantibodies; D012334:RNA, Neoplasm