title: Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli.
abstract: Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR.
mesh_terms: D002845:Chromatography; D003227:Conjugation, Genetic; D004794:Enzyme Repression; D004926:Escherichia coli / Q000201:enzymology* / Q000254:growth & development; D005809:Genes, Regulator; D005827:Genetics, Microbial; D006539:Heptoses / Q000096:biosynthesis; D006836:Hydro-Lyases / Q000378:metabolism; D007535:Isomerases / Q000378:metabolism; D008025:Ligases / Q000032:analysis / Q000378:metabolism*; D008967:Molecular Biology; D009154:Mutation; D012641:Selection, Genetic; D000637:Transaminases / Q000378:metabolism; D014161:Transduction, Genetic; D014443:Tyrosine / Q000096:biosynthesis* / Q000494:pharmacology
chemical_list: D006539:Heptoses; D014443:Tyrosine; D000637:Transaminases; D006836:Hydro-Lyases; D007535:Isomerases; D008025:Ligases