Colicin-tolerant mutants of Escherichia coli: resistance of membranes to colicin E1.
Colicin E1 blocks proline accumulation by membrane vesicles prepared from wild-type sensitive Escherichia coli. Two classes of mutant cells are unaffected by colicin. Vesicles from colicin-resistant strains are sensitive to colicin E1, whereas vesicles from colicin-tolerant strains are unaffected by colicin El. These results suggest that the colicin E1 receptor is on the cell membrane and that colicin-tolerant strains have altered membranes while colicin-resistant strains have altered cell walls.
D001692:Biological Transport; D002247:Carbon Isotopes; D002462:Cell Membrane / Q000378:metabolism*; D003087:Colicins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D011392:Proline / Q000378:metabolism*; D011955:Receptors, Drug
D002247:Carbon Isotopes; D003087:Colicins; D011955:Receptors, Drug; D011392:Proline