Mouse lysozyme production by a monocytoma: isolation and comparison with other lysozymes.
A transplantable mouse tumor, GPC-11, produces large amounts of lysozyme. The tumor is a reticulum cell sarcoma, type A, and is a neoplasm of monocytes. The lysozyme was purified from mouse urine in quantities sufficient for structural analysis. Comparison of mouse lysozyme with lysozymes from; chicken egg white and patients with monocytic leukemia reveals similarities in size and electrophoretic mobility and, with human lysozyme, in functional properties; but considerable differences are found in antigenic characteristics and amino acid composition.
D000818:Animals; D002852:Chromatography, Ion Exchange; D004529:Egg White; D004586:Electrophoresis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007951:Leukemia, Myeloid / Q000201:enzymology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology*; D051379:Mice; D009000:Monocytes; D009113:Muramidase / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood / Q000302:isolation & purification / Q000652:urine; D014461:Ultracentrifugation
D009113:Muramidase