title: Enhancement of St. Louis arbovirus plaque formation by neutral red.
abstract: Experiments with St. Louis encephalitis (SLE) virus have shown that neutral red enhances the plaque size in duck embryo cell cultures. This may represent a new method for genetic studies of SLE virus population. In a mosquito pool specimen NR(+) and NR(-) particles were demonstrated. By intracerebral passage in mice, there is a selection of NR(+) particles. Similar effects were not shown for eastern, western, and California encephalitis viruses. Plaques formed by the latter virus, however, were significantly reduced in number by neutral red.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D004396:Coloring Agents / Q000494:pharmacology*; D046508:Culture Techniques; D004372:Ducks; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D004668:Encephalitis Viruses / Q000187:drug effects / Q000276:immunology*; D005827:Genetics, Microbial; D006462:Hemolytic Plaque Technique; D051379:Mice
chemical_list: D004396:Coloring Agents