title: Antiserum to lymphocytes and procarbazine compared as immunosuppressants in mice.
abstract: As an immunosuppressant procarbazine was as potent as an antiserum to lymphocytes in mice. Both agents significantly prolonged survivals of skin allografts by 4 to 6 weeks. At the maximum tolerated dosage, procarbazine suppressed both circulating hemagglutinins to sheep erythrocytes and plaque-forming cells in the spleen. The antiserum to lymphocytes reduced the numbers of circulating hemagglutinins and plaque-forming cells by 94 percent. Procarbazine was administered to mice for 3 weeks before their exposure to antigen. Exposure for only 9 days, commencing 48 hours before injection of sheep erythrocytes, was less effective in suppressing the titers of hemagglutinins.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum; D001565:Benzoates / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D001565:Benzoates; D007166:Immunosuppressive Agents