Antigenic structure of Treponema pallidum, Nichols strain. II. Extraction of a polysaccharide antigen with "strain-specific" serological activity.
An ultracentrifugally homogeneous heat-stable polysaccharide preparation free from serologically reactive rabbit testicular tissue antigen, including cardiolipin, was extracted from the Nichols strain of Treponema pallidum, and found to react by complement-fixation with homologous rabbit sera but not with human syphilitic sera. In addition, the reactive "strain-specific" component was found to be distinct from a second reactive component within the preparation related to an antigen of T. reiteri.
D000818:Animals; D003168:Complement Fixation Tests; D006801:Humans; D007106:Immune Sera; D010743:Phospholipids; D011135:Polysaccharides, Bacterial / Q000302:isolation & purification*; D011817:Rabbits; D013045:Species Specificity; D013588:Syphilis Serodiagnosis; D014210:Treponema pallidum / Q000276:immunology*
D007106:Immune Sera; D010743:Phospholipids; D011135:Polysaccharides, Bacterial