Single-blind comparative trial of trimethoprim-sulphamethoxazole and ampicillin in the treatment of exacerbations of chronic bronchitis.
Fifty patients with exacerbations of chronic bronchitis were treated with either a combination of trimethoprim 320 mg. and sulphamethoxazole 1,600 mg. a day or ampicillin 2 g. a day. The trial, carried out as a single-blind procedure, showed that the combination was more effective as judged by clinical response and reduction in sputum volume and purulence, with eradication of pathogenic organisms. No appreciable side-effects were encountered with either treatment, and it is suggested that the trimethoprim-sulphamethoxazole combination may be a safe and useful drug in the treatment of chronic bronchitis.
D000667:Ampicillin / Q000008:administration & dosage*; D001772:Blood Cell Count; D001991:Bronchitis / Q000188:drug therapy*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004357:Drug Synergism; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage*; D013183:Sputum / Q000382:microbiology; D013420:Sulfamethoxazole / Q000008:administration & dosage*
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D000667:Ampicillin; D013420:Sulfamethoxazole