Clinical trial of the effect of vitamin B12 in elderly subjects with low serum B12 levels.
A clinical trial of the effect of vitamin B(12) therapy was conducted in 39 elderly subjects who had been found, in a community screening survey, to have low levels of serum B(12) without a macrocytic anaemia or neuropathy. The study produced no evidence which suggests that in such subjects B(12) is superior to placebo in effecting an improvement in psychiatric state or general well-being. There was a clear tendency for all the subjects to show an improvement during the trial, but this probably represents the therapeutic effect of involvement in a research exercise of this kind.
D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010919:Placebos; D014805:Vitamin B 12 / Q000097:blood* / Q000627:therapeutic use*; D014806:Vitamin B 12 Deficiency / Q000188:drug therapy
D010919:Placebos; D014805:Vitamin B 12