Cross-reactions between streptococcal M proteins and human transplantation antigens.
Allogeneic antiserums against human lymphocytes were specifically inhibited by M protein from beta hemolytic group A Streptococcus pyogenes, type 1. Analogous M proteins from streptococcus types 3, 4, 5, 6, 12, and 14 had little or no inhibitory activity. The specific inhibition by M protein is not a result of anticomplementary activity or of coating of the lymphocyte surface. Streptococcal polysaccharide and 73 other polysaccharides were inactive. Because all seven HL-A specificities tested were inhibited, it is inferred that M1 protein has a structure common to human histocompatibility antigens.
D000937:Antigen-Antibody Reactions; D001426:Bacterial Proteins; D003429:Cross Reactions; D006801:Humans; D007106:Immune Sera; D011135:Polysaccharides, Bacterial; D013297:Streptococcus pyogenes / Q000276:immunology*; D014181:Transplantation Immunology
D001426:Bacterial Proteins; D007106:Immune Sera; D011135:Polysaccharides, Bacterial