New concepts of digitalis.
The data presented in this review have substantiated the following ideas:* There is a direct relationship between digitalis dosage and myocardial contractile force. A small dose of digitalis produces a small increase of the contractile force of the heart and a large dose increases the force of the heart's contraction by a much greater amount, whether the heart is normal, has a poor reserve, or is in frank failure.* Digitalis is of benefit to the patient with cardiovascular disease whether his heart is in failure or not.
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy; D004071:Digitalis Glycosides / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004285:Dogs; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy; D011300:Preoperative Care; D011817:Rabbits; D012769:Shock / Q000188:drug therapy; D013514:Surgical Procedures, Operative; D013906:Thoracoscopy
D004071:Digitalis Glycosides