Mutator gene studies in Escherichia coli.
An Escherichia coli mutator gene, mutT, has been shown by P1-mediated crosses to map between the leucine and azide loci. The mutT1 and azi-r alleles cotransduce with a frequency of >92%. In mutT1/mutT(+) merodiploids, the mutT1 phenotype is recessive; in mutT1/F'trp or mutT1/F'lac merodiploids, the mutT1 allele has a trans effect. The gene can mutate lambda and T7 phage but not T1, T3, T4, T5, and S13.
D002874:Chromosome Mapping; D003090:Coliphages; D004926:Escherichia coli; D005796:Genes; D005808:Genes, Recessive; D005827:Genetics, Microbial; D008967:Molecular Biology; D009154:Mutation; D010641:Phenotype; D014161:Transduction, Genetic