title: Origin and direction of replication of the chromosome of E. coli B-r.
abstract: The origin and direction of replication of the E. coli B/r chromosome has been determined by comparing gene frequencies in P1-transducing lysates prepared on cultures growing at different rates. The gene frequencies found are consistent with the idea that replication of the chromosome is dichotomous in rapidly growing B/r. The origin was found to be between 40 and 55 min on the E. coli genetic map with replication proceeding in a clockwise direction. Markers near the origin behaved anomalously.
mesh_terms: D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004261:DNA Replication; D004269:DNA, Bacterial; D004926:Escherichia coli; D014161:Transduction, Genetic
chemical_list: D004269:DNA, Bacterial