Inhibition of peptic activity by carbenoxolone and glycyrrhetinic acid.
Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activity and caused no reduction in total acidity. Antipeptic activity of carbenoxolone has also been demonstrated in vitro using the pepsin plate technique and the haemoglobin pepsin assay.It is suggested that these actions of carbenoxolone may contribute to the increased rate of healing of peptic ulcer in patients treated with the drug.
D000818:Animals; D005750:Gastric Juice / Q000187:drug effects*; D006035:Glycyrrhiza; D066298:In Vitro Techniques; D010434:Pepsin A / Q000032:analysis / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal; D011708:Pylorus / Q000502:physiology; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology; D013729:Terpenes / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D013729:Terpenes; D013148:Spironolactone; D010434:Pepsin A