Hormonal stimulation of lactose synthetase in mammary carcinoma.
A transplantable rat mammary carcinoma (R3230AC) synthesizes significant quantities of the mammary gland enzyme lactose synthetase in the immature virgin female rat. In this hormonal environment, mammary glands do not synthesize the enzyme. Prolactin further stimulates the enzyme activity in the tumors to levels found only in mammary glands of rats in late pregnancy or during lactation.
D000230:Adenocarcinoma / Q000201:enzymology*; D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D007774:Lactation; D007785:Lactose / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000201:enzymology; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology*; D009368:Neoplasm Transplantation; D010546:Perphenazine / Q000494:pharmacology; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D011247:Pregnancy; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D014166:Transferases / Q000096:biosynthesis*
D010906:Pituitary Hormone-Releasing Hormones; D011388:Prolactin; D014166:Transferases; D010546:Perphenazine; D007785:Lactose