Nifuratel compared with metronidazole in the treatment of trichomonal vaginitis.
Nifuratel (Magmilor) was compared with metronidazole (Flagyl) in the treatment of trichomonal vaginitis by a randomized double-blind trial. Only 18 out of 47 patients (38%) treated with nifuratel were found to be cured, whereas 42 out of 49 patients (85%) treated with metronidazole were cured. Severe reactions, necessitating withdrawal of treatment, occurred in three patients treated with nifuratel. There were no serious side-effects with metronidazole. The results of this trial indicate that nifuratel is not a satisfactory substitute for metronidazole in the treatment of trichomoniasis.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004342:Drug Hypersensitivity; D005260:Female; D006069:Gonorrhea / Q000150:complications; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use*; D010080:Oxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D014247:Trichomonas Vaginitis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D014581:Urticaria / Q000139:chemically induced
D010080:Oxazoles; D008795:Metronidazole