Effect of pH on in vitro phagocytosis of Streptococcus pyogenes.
Phagocytosis experiments were performed with mouse peritoneal leucocytes (MPL). The natural pH of the mouse peritoneal cavity was found to be between 6.1 and 6.3. The phagocytic and intracellular killing activities of MPL by pH variations was studied. It was observed that the optimal ingestion and intracellular killing of bacteria is at the natural pH of the peritoneal cavity.
D000818:Animals; D005260:Female; D006863:Hydrogen-Ion Concentration; D007962:Leukocytes; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity; D010587:Phagocytosis; D013297:Streptococcus pyogenes