Inhibition of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (trp) in Escherichia coli.
The growth of a strain of Escherichia coli K-12 which possesses only the single isoenzyme 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase (trp), and which makes this enzyme constitutively, is inhibited by tryptophan. The accumulation of DAHP by a derivative of this strain unable to convert DAHP to dehydroquinate is also inhibited by tryptophan. The enzymic activity of DAHP synthetase (trp) in the presence of CO(2+) is sensitive to inhibition by tryptophan. Mutant strains of E. coli have been isolated in which DAHP synthetase (trp) is feedback-resistant.
D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004794:Enzyme Repression; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D005246:Feedback; D006539:Heptoses / Q000096:biosynthesis; D008025:Ligases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009154:Mutation; D010428:Pentosephosphates / Q000378:metabolism; D014364:Tryptophan / Q000494:pharmacology*
D006539:Heptoses; D010428:Pentosephosphates; D014364:Tryptophan; D008025:Ligases