title: Controlled trial of metoclopramide in the treatment of flatulent dyspepsia.
abstract: A double-blind cross-over trial of metoclopramide (Maxolon) against placebo was undertaken in 42 patients with flatulent dyspepsia. A highly significant difference was found in favour of the active drug (P<0.01). The time at which the drug is given in relation to the meal and onset of symptoms is probably important. It is concluded that metoclopramide is effective in the short-term treatment of these symptoms but should be started only after thorough investigations have excluded more serious disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000627:therapeutic use*; D001466:Barium Sulfate; D001565:Benzoates / Q000627:therapeutic use*; D002763:Cholecystectomy / Q000009:adverse effects; D002765:Cholecystography; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D004415:Dyspepsia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005414:Flatulence / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014628:Vagotomy / Q000009:adverse effects
chemical_list: D000577:Amides; D001565:Benzoates; D001466:Barium Sulfate