Chemosterilant action of anthramycin: a proposed mechanism.
The activity of anthramycin and structurally related analogs as chemosterilants of the housefly, Musca domestica L., correlates closely with the action of these compounds as inhibitors of Escherichia coli RNA polymerase. Since inhibition of RNA polymerase by anthramycin reflects binding of this antibiotic to the DNA primer required for enzyme activity, we propose that the interaction of anthramycin with DNA may also account for its action as a chemosterilant.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D002629:Chemosterilants / Q000494:pharmacology*; D004247:DNA / Q000494:pharmacology; D004347:Drug Interactions; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D006793:Houseflies / Q000187:drug effects*; D008297:Male; D012316:RNA Nucleotidyltransferases / Q000037:antagonists & inhibitors
D000903:Antibiotics, Antineoplastic; D001552:Benzazepines; D002629:Chemosterilants; D004247:DNA; D012316:RNA Nucleotidyltransferases