Carcinogen and microsomal membrane interactions: changes in membrane density and ability to bind nucleic acids.
DNA and synthetic copolymer polyribocytidylic-polyriboguanylic acid bind to microsomal membrane. The nucleic acid-membrane complex may be detected by centrifugation in cesium chloride density gradients. The density of the nucleic acid-membrane complex and, in certain cases, the amount of nucleic acid associated with the membrane was changed in the presence of various carcinogenic chemicals.
D000818:Animals; D001665:Binding Sites; D002273:Carcinogens / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor; D002499:Centrifugation, Density Gradient; D003597:Cytosine Nucleotides / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism*; D004926:Escherichia coli; D006150:Guanine Nucleotides / Q000378:metabolism; D008566:Membranes / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism*; D011119:Polynucleotides / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats; D013046:Specific Gravity
D002273:Carcinogens; D003597:Cytosine Nucleotides; D004269:DNA, Bacterial; D006150:Guanine Nucleotides; D011119:Polynucleotides; D012329:RNA, Bacterial; D012334:RNA, Neoplasm