Two compounds inhibitory to penicillinase-producing cells of Staphylococcus aureus.
2-[4-(4,6-Diamino-1, 2-dihydro-2, 2-dimethyl-S-triazin-1-yl)phenyl]-4'-(fluorosulfonyl) acetanilide ethane sulfonate salt and 4-(p-tert-butylbenzoyl)-3-methyl-1-phenyl-2-pyrazolin-5-one cause a shift in growing populations of plasmid-bearing Staphylococcus aureus cells to a population of cells lacking the plasmid.
D000083:Acetanilides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001431:Bacteriological Techniques; D001565:Benzoates / Q000494:pharmacology; D003470:Culture Media; D005827:Genetics, Microbial; D009154:Mutation; D010405:Penicillinase / Q000096:biosynthesis*; D011720:Pyrazoles / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D013451:Sulfonic Acids / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology*
D000083:Acetanilides; D000900:Anti-Bacterial Agents; D001565:Benzoates; D003470:Culture Media; D011720:Pyrazoles; D013451:Sulfonic Acids; D014227:Triazines; D010405:Penicillinase