Effects of actinobolin on growth and some metabolic activities of cariogenic streptococci in vitro and in vivo.
Actinobolin, a known inhibitor of protein synthesis, has been shown not to interfere selectively with acid production or dextransucrase activity in a cariogenic streptococcus when the antibiotic is added to a concentration of 500 mug/ml. It has also been shown that actinobolin does not alter the total in vivo flora of the oral cavity of the rat when tested in a rat caries model system. A culture of cariogenic streptococci, adapted to in vitro growth in the presence of 1 mg of actinobolin per ml, has also been isolated.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001431:Bacteriological Techniques; D003470:Culture Media; D003731:Dental Caries / Q000517:prevention & control*; D003911:Dextrans / Q000096:biosynthesis; D004032:Diet; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D005827:Genetics, Microbial; D005964:Glucosyltransferases / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D008963:Molar; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D013291:Streptococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D013752:Tetracycline / Q000627:therapeutic use; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media; D003911:Dextrans; D005964:Glucosyltransferases; D013752:Tetracycline