title: New patterns of immunoglobulin deposition in the lesions of malignant nephrosclerosis, with special reference to IgE.
abstract: Localization of immunoglobulins (including IgE), complement and fibrinogen and the morphologic alterations in the kidneys of 10 patients with malignant nephrosclerosis were investigated. Thirteen kidneys with benign nephrosclerosis and 5 normal ones were also studied. In contrast to a previous series of patients with malignant nephrosclerosis, the number of necrotic arterioles and the deposition of IgG and complement in the renal arterioles, were reduced in a parallel fashion. These differences seem to reflect modern treatment and support the hypothesis that IgG and complement play a role in the pathogenesis of the arteriolar necrosis in the disease. IgE was deposited massively in many renal arterioles of 9 patients with malignant nephrosclerosis. The role of reaginic antibody in the pathogenesis of the disease is not clear since IgE was also focally present in some arterioles of 4 normal kidneys and of 8 kidneys with benign nephrosclerosis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins; D005260:Female; D005340:Fibrinogen; D005455:Fluorescent Antibody Technique; D006801:Humans; D007073:Immunoglobulin E; D007136:Immunoglobulins; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
chemical_list: D007136:Immunoglobulins; D007073:Immunoglobulin E; D005340:Fibrinogen; D003165:Complement System Proteins