Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.
The possibility that a rat alloantiserum DA anti-Lewis possesses similar recognition structures for Lewis transplantation antigens, as do DA immunocompetent cells, was investigated by raising an antiserum against this alloantiserum in (Lewis x DA)F(1) hosts. This antiserum, as well as one provoked by injecting DA lymphoid cells, was active against recognition structures for Lewis antigens of DA immunocompetent cells. The anti-(DA anti-Lewis) antiserum displayed the same degree of specificity as was found previously for anti-recognition structure sera prepared by injecting parental strain lymphoid cells into F(1) hosts. Since the activities of antisera raised against cell-bound receptors or against the antigen-binding region of an immunoglobulin were indistinguishable, it was concluded that the functional part of cell-associated receptors might be structurally similar to the variable portion of an immunoglobulin.
D000818:Animals; D000921:Antibody-Producing Cells; D000937:Antigen-Antibody Reactions; D005260:Female; D006084:Graft Rejection; D007106:Immune Sera / Q000494:pharmacology*; D007136:Immunoglobulins; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051381:Rats; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D014181:Transplantation Immunology / Q000187:drug effects*
D007106:Immune Sera; D007136:Immunoglobulins