New approaches to chemotherapy with folate antagonists: use of leucovorin "rescue" and enzymic folate depletion.
D000328:Adult; D000818:Animals; D002268:Carboxypeptidases / Q000008:administration & dosage; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003857:Deoxyuridine; D004032:Diet; D004338:Drug Combinations; D004357:Drug Synergism; D005493:Folic Acid Antagonists / Q000008:administration & dosage*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage*; D007939:Leukemia L1210 / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood / Q000633:toxicity; D051379:Mice; D051381:Rats; D014316:Tritium
D004338:Drug Combinations; D005493:Folic Acid Antagonists; D014316:Tritium; D002268:Carboxypeptidases; D002955:Leucovorin; D003857:Deoxyuridine; D008727:Methotrexate