Transfer amyloidosis. I. Studies on the transfer of various lymphoid cells from amyloidotic mice to syngeneic nonamyloidotic recipients. II. Induction of amyloidosis in mice with spleen, thymus and lymph node tissue from casein-sensitized syngeneic donors.
Lymphoid cells from various lymphoid organs were transferred from amyloidotic mice to normal syngeneic recipients. The recipients were treated with nitrogen mustard. Only the recipients of spleen cells developed amyloidosis. Furthermore, slices of spleen, thymus and lymph node from casein-sensitized mice were transplanted to kidneys of normal syngeneic mice. The recipients were treated with ten casein injections, and they all developed amyloidosis. The results from both experiments indicate that amyloid is formed by macrophages due to a stimulation of these cells with both antigen and an amyloid-inducing factor released from the pyroninophilic lymphoid cells.
D000686:Amyloidosis / Q000276:immunology*; D000818:Animals; D000941:Antigens; D016026:Bone Marrow Transplantation; D002364:Caseins; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007668:Kidney; D008198:Lymph Nodes / Q000637:transplantation; D008221:Lymphoid Tissue / Q000637:transplantation*; D008264:Macrophages; D008297:Male; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology; D010537:Peritoneum / Q000637:transplantation; D013154:Spleen / Q000637:transplantation; D013950:Thymus Gland / Q000637:transplantation; D013997:Time Factors; D014181:Transplantation Immunology
D000941:Antigens; D002364:Caseins; D009588:Nitrogen Mustard Compounds