title: Active-site directed irreversible inhibitors of dihydrofolate reductase.
mesh_terms: D000630:Aminopterin / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D001693:Biological Transport, Active / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology; D005493:Folic Acid Antagonists / Q000378:metabolism / Q000627:therapeutic use; D007422:Intestines / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D007939:Leukemia L1210 / Q000188:drug therapy / Q000201:enzymology; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D011739:Pyrimethamine / Q000494:pharmacology; D051381:Rats; D013154:Spleen / Q000201:enzymology; D013329:Structure-Activity Relationship; D013997:Time Factors; D014227:Triazines / Q000494:pharmacology
chemical_list: D005493:Folic Acid Antagonists; D014227:Triazines; D000630:Aminopterin; D008727:Methotrexate; D011739:Pyrimethamine