Stimulative effect of elemental sulfur on siomycin production by Streptomyces sioyaensis.
The addition of elemental sulfur to the fermentation of Streptomyces sioyaensis in a soybean meal medium resulted in a three- to fourfold increase of siomycin. Further experiments on the effect of elemental sulfur during fermentation suggest that one of the key steps stimulating siomycin synthesis is the utilization of thiosulfate, which accumulates in the medium as the result of the oxidation of elemental sulfur.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001431:Bacteriological Techniques; D002854:Chromatography, Paper; D002855:Chromatography, Thin Layer; D003470:Culture Media; D005285:Fermentation; D010084:Oxidation-Reduction; D013025:Glycine max; D013053:Spectrophotometry; D013268:Stimulation, Chemical; D013302:Streptomyces / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism / Q000494:pharmacology*; D013885:Thiosulfates / Q000096:biosynthesis / Q000378:metabolism; D013997:Time Factors
D000900:Anti-Bacterial Agents; D003470:Culture Media; D013885:Thiosulfates; D013455:Sulfur