Trimethoprim and sulphamethoxazole in typhoid fever in children.
One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol. The bacteriological response to trimethoprim-sulphamethoxazole was unsatisfactory. From this study it seems that at present chloramphenicol is still the treatment of choice for typhoid fever. In view of the haematological changes occurring during therapy with trimethoprim-sulphamethoxazole caution is necessary and monitoring of the blood picture advisable, even at the recommended dose.
D000380:Agranulocytosis / Q000139:chemically induced; D000741:Anemia, Aplastic / Q000139:chemically induced; D001769:Blood / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000627:therapeutic use; D005260:Female; D005493:Folic Acid Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006454:Hemoglobins; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009504:Neutrophils; D011743:Pyrimidines / Q000009:adverse effects / Q000627:therapeutic use*; D012486:Salmonella typhimurium / Q000302:isolation & purification; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000627:therapeutic use*; D014435:Typhoid Fever / Q000188:drug therapy*
D005493:Folic Acid Antagonists; D006454:Hemoglobins; D011743:Pyrimidines; D002701:Chloramphenicol; D013420:Sulfamethoxazole