Treatment of zoster with idoxuridine in dimethyl sulphoxide. Results of two double-blind controlled trials.
The antiviral effect of 5% idoxuridine in dimethyl sulphoxide intermittently applied and of 40% idoxuridine in dimethyl sulphoxide continuously applied for four days to the lesions in patients with zoster of recent onset was studied in two double-blind controlled trials. Most, but not all, of the patients receiving intermittent active treatment had pain for a short period only. The effect of continuous treatment was striking: pain had disappeared within nine days in all the patients and healing was accelerated. The results were statistically significant.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002648:Child; D002986:Clinical Trials as Topic; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004304:Dosage Forms; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D004304:Dosage Forms; D007065:Idoxuridine; D004121:Dimethyl Sulfoxide