title: Immunocompetent cells of the chicken. I. Specific surface antigenic markers on bursa and thymus cells.
abstract: Specific antisera to chicken thymus and to bursa of Fabricius were obtained in rabbits. After appropriate absorption and dilution all four anti-thymus sera, in the presence of guinea pig C', killed >90% of thymus and <==12% of bursa cells. They were cytotoxic for approximately 50% of spleen cells and did not affect antibody-forming cells. The surface antigen detected by these antisera was named chicken T-lymphocyte antigen (CTLA). Two of four anti-bursa sera, under similar conditions, killed >90% of bursa cells and <==10% of thymus cells. These antisera were cytotoxc for a large percentage of antibody-forming cells and killed approximately 30% of spleen cells The other two anti-bursa sera were somewhat less potent but showed similar specificity. The surface antigen detected by these antisera was named chicken bursa-derived lymphocyte antigen (CBuLA). Rabbit antisera to chicken immunoglobulin were cytotoxic for bursa but not for thymus cells and killed a similar percentage of spleen cells as did anti-bursa sera. They were also cytotoxic for antibody-forming cells.
mesh_terms: D000818:Animals; D000921:Antibody-Producing Cells; D000941:Antigens; D000961:Antilymphocyte Serum; D002060:Bursa of Fabricius / Q000276:immunology*; D002462:Cell Membrane; D002645:Chickens; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000502:physiology*; D007111:Immunity, Cellular; D007136:Immunoglobulins; D011817:Rabbits; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology*
chemical_list: D000941:Antigens; D000961:Antilymphocyte Serum; D007106:Immune Sera; D007136:Immunoglobulins; D003165:Complement System Proteins