title: Folic acid in folate-deficient patients with epilepsy.
abstract: A double-blind trial using folic acid 15 mg. daily and identical placebo was carried out in 51 epileptic patients having a serum folate level below 3.6 ng./ml. Treatment was for a minimum of six months and in 41 patients was for more than one year. There were no significant changes in the frequency of seizures, behaviour, and personality, or in a number of cognitive functions.
mesh_terms: D000293:Adolescent; D000328:Adult; D001519:Behavior; D002986:Clinical Trials as Topic; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008568:Memory; D008875:Middle Aged; D010555:Personality Inventory; D010919:Placebos
chemical_list: D010919:Placebos; D005492:Folic Acid