Response of HL-A identical unrelated individuals in the mixed lymphocyte culture test.
The immunological responsiveness as measured in the mixed lymphocyte culture test has been studied in 13 pairs of HL-A identical unrelated individuals. In all combinations stimulation occurred and it was frequently of a similar magnitude to that observed against non-HL-A identical subjects.It is postulated that another locus, adjacent to the HL-A locus, is also responsible for the non-stimulation observed between HL-A identical siblings, and that observations made in the related situation should not be transposed to the unrelated situation without some reservation.
D003601:Cytotoxicity Tests, Immunologic; D005796:Genes; D006648:Histocompatibility; D006801:Humans; D007519:Isoantigens; D016030:Kidney Transplantation; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D010641:Phenotype; D013936:Thymidine / Q000378:metabolism; D014184:Transplantation, Homologous; D014316:Tritium
D007519:Isoantigens; D037102:Lectins; D014316:Tritium; D013936:Thymidine