Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.
A tuberculin carbohydrate fraction, GAE, in sensitized animals induced a delayed type of skin reactivity and inhibited the migration of macrophages but failed to stimulate lymphocyte transformation in vitro. Tuberculin protein-containing fractions were active in each test. These results show that in vitro lymphocyte transformation is not necessarily a corollary of delayed type hypersensitivity.
D000818:Animals; D000941:Antigens; D002465:Cell Movement; D003864:Depression, Chemical; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D012882:Skin Tests; D014373:Tuberculin / Q000032:analysis*
D000941:Antigens; D011135:Polysaccharides, Bacterial; D014373:Tuberculin