Effect of nalidixic acid on semionservative replication and repair synthesis after ultraviolet irradiation in Escherichia coli.
Both semiconservative deoxyribonucleic acid replication and "extensive repair" synthesis, after ultraviolet irradiation, appear to be blocked by nalidixic acid. These findings suggest that the agent(s) responsible for both of these modes of replication, or some necessary common process or structure, is affected by this drug.
D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D002586:Cesium; D002712:Chlorides; D003470:Culture Media; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism* / Q000528:radiation effects; D005827:Genetics, Microbial; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology*; D011830:Radiation Effects; D013941:Thymine / Q000378:metabolism; D014316:Tritium; D014466:Ultraviolet Rays
D002247:Carbon Isotopes; D002712:Chlorides; D003470:Culture Media; D004269:DNA, Bacterial; D014316:Tritium; D002586:Cesium; D009268:Nalidixic Acid; D013941:Thymine