title: Effect of cigarette smoking on human gastric secretory responses.
abstract: The effect of smoking three cigarettes over a one-hour period on the pentagastrinstimulated submaximal plateau of acid and pepsin secretion was observed in 12 healthy human volunteers comprising men and women and smokers and non-smokers. No significant overall change in secretion was observed. In one subject, however, acid secretion was significantly inhibited (p < 0.01) and in one individual significant late stimulation (p < 0.01) of both acid and pepsin was observed.
mesh_terms: D000328:Adult; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010434:Pepsin A / Q000378:metabolism; D010437:Peptic Ulcer / Q000209:etiology; D012907:Smoking / Q000503:physiopathology*; D013270:Stomach / Q000187:drug effects*; D013997:Time Factors
chemical_list: D010434:Pepsin A