Homograft rejection delayed by treatment of donor tissue in vitro with antilymphocyte serum.
Treatment of rabbit corneal tissue in vitro with pooled rabbit serum delays the onset of corneal homograft rejection in the host. Addition of antilymphocyte serum results in a further significant delay in the onlset of rejection. The mechanisms by which such treatment of donor tissues may modify the antigenic content of the material are discussed.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D016039:Corneal Transplantation; D006084:Graft Rejection / Q000187:drug effects; D011817:Rabbits; D016038:Skin Transplantation; D013997:Time Factors; D014181:Transplantation Immunology / Q000187:drug effects*; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum