Effect of serine hydroxamate on the growth of Escherichia coli.
The structural analogue of l-serine, l-serine hydroxamate, inhibited the growth of Escherichia coli K-12. Of the other amino acid hydroxamates tested, only l-lysine hydroxamate reduced the rate of growth. Inhibition of growth by l-serine hydroxamate was rapidly reversed by the addition of l-serine to the bacterial culture or by removal of the analogue by filtration. The reversal of inhibition was specific for l-serine. l-Alanine, glycine, or adenine had no effect on an inhibited culture. No evidence for active transport of the analogue was obtained.
D000225:Adenine / Q000378:metabolism; D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000494:pharmacology; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D003470:Culture Media; D003720:Densitometry; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D005374:Filtration; D005998:Glycine / Q000378:metabolism; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007202:Indicators and Reagents; D012694:Serine / Q000378:metabolism / Q000494:pharmacology*; D013053:Spectrophotometry; D013237:Stereoisomerism; D014316:Tritium
D000596:Amino Acids; D002247:Carbon Isotopes; D003470:Culture Media; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D014316:Tritium; D012694:Serine; D000225:Adenine; D000409:Alanine; D005998:Glycine