Kidney biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man.
A study of early glomerular lesions was made in 8 patients infected with Schistosoma mansoni but having no clinical evidence of renal disease. Electron-microscopy of renal biopsies showed the presence of electron-dense deposits in basement membranes and of laminated bodies near the mesangial cells. Immunofluorescence showed that the deposits corresponded to IgG in 8 cases and to IgM in 2 cases. These lesions are comparable with those found in the kidneys of patients with cirrhosis of the liver.
D001706:Biopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000473:pathology*; D008109:Liver Diseases, Parasitic / Q000473:pathology*; D008854:Microscopy, Electron; D012552:Schistosomiasis / Q000473:pathology*; D013158:Splenic Diseases / Q000473:pathology*