title: Evidence that the majority of leucine transfer ribonucleic acid is not involved in repression in Salmonella typhimurium.
abstract: Leucine transfer ribonucleic acid (tRNA) was almost fully charged, and the isoleucine-valine and leucine enzymes remained derepressed when trifluoroleucine was added to a leucine auxotroph. High levels of charged leucine tRNA and derepression were also found in a leucyl-tRNA synthetase mutant.
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D003470:Culture Media; D004794:Enzyme Repression / Q000187:drug effects; D005461:Fluorine / Q000494:pharmacology; D005827:Genetics, Microbial; D006836:Hydro-Lyases / Q000378:metabolism; D007532:Isoleucine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism* / Q000494:pharmacology; D008190:Lyases / Q000378:metabolism; D009154:Mutation; D011773:Pyruvates; D012329:RNA, Bacterial / Q000302:isolation & purification; D012343:RNA, Transfer / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D013912:Threonine; D046249:Transfer RNA Aminoacylation; D014633:Valine / Q000378:metabolism
chemical_list: D003470:Culture Media; D011773:Pyruvates; D012329:RNA, Bacterial; D007532:Isoleucine; D005461:Fluorine; D013912:Threonine; D012343:RNA, Transfer; D008190:Lyases; D006836:Hydro-Lyases; D000604:Amino Acyl-tRNA Synthetases; D007930:Leucine; D014633:Valine