Specific heterologous enhancement of immune responses.
In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures from unprimed donors produced a small depression in the number of such plaques.
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006386:Hemagglutination Tests; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular; D007114:Immunization; D051379:Mice; D010047:Ovalbumin; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013745:Tetanus Toxoid; D013997:Time Factors
D000941:Antigens; D013745:Tetanus Toxoid; D010047:Ovalbumin