title: Inhibition of gastric secretion by atropine in conscious rats.
abstract: 1. The effect of atropine on acid and pepsin secretion, stimulated by feeding, vagus excitation or infusions of gastrin, histamine and methacholine, was studied in conscious rats provided with a Pavlov or a Heidenhain pouch.2. The acid and pepsin secretion in response to food was substantially suppressed by atropine in the Pavlov pouch.3. The strong stimulatory effect of 2-deoxy-D-glucose on acid and pepsin secretion in the Pavlov pouch was almost abolished by atropine.4. A plateau secretion of acid obtained by infusion of submaximal doses of hog gastrin II, was significantly inhibited by atropine in the Pavlov and the Heidenhain pouch.5. Methacholine-induced acid and pepsin secretion in the denervated Heidenhain pouch was nearly completely inhibited by atropine.6. A plateau secretion of acid evoked by infusing histamine in a near maximal dosage was inhibited by atropine to the same extent as the gastrin-induced secretion in the Pavlov pouch.7. The mode of action of atropine as a gastric secretory inhibitor is discussed.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003864:Depression, Chemical; D004435:Eating; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology; D005947:Glucose / Q000037:antagonists & inhibitors; D006601:Hexoses / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D008688:Methacholine Compounds / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism*; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical; D013552:Swine; D013997:Time Factors; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D005755:Gastrins; D006601:Hexoses; D008688:Methacholine Compounds; D001285:Atropine; D006632:Histamine; D010434:Pepsin A; D005947:Glucose