Leucopenia associated with trimethoprim-sulphamethoxazole after renal transplantation.
Four patients who had received cadaveric renal allografts developed a profound and sustained leucopenia in association with a trimethoprim-sulphamethoxazole preparation. Ten other cadaveric renal allograft recipients received identical chemotherapy with no adverse effects. Statistical analysis showed that the association of leucopenia and trimethoprim-sulphamethoxazole therapy was dependent on the time after the transplantation procedure and was not related to the dosage of immunosuppressive chemotherapy or renal function.
D001379:Azathioprine / Q000627:therapeutic use; D002102:Cadaver; D003404:Creatinine / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000009:adverse effects*; D006801:Humans; D016030:Kidney Transplantation; D007970:Leukopenia / Q000139:chemically induced*; D011743:Pyrimidines / Q000009:adverse effects*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D013997:Time Factors; D014184:Transplantation, Homologous; D014552:Urinary Tract Infections / Q000188:drug therapy
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D003404:Creatinine; D013420:Sulfamethoxazole; D001379:Azathioprine