title: Number of binding sites and possible mechanisms of action.
mesh_terms: D000630:Aminopterin / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D001665:Binding Sites; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000378:metabolism*; D002955:Leucovorin / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008727:Methotrexate / Q000378:metabolism; D051379:Mice; D011485:Protein Binding; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism
chemical_list: D005493:Folic Acid Antagonists; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D000630:Aminopterin; D002955:Leucovorin; D008727:Methotrexate