Antigen-specific synergism in the immune response of irradiated mice given marrow cells and peritoneal cavity cells or extracts.
A synergistic immune response to foreign erythrocytes may be induced in heavily irradiated mice injected with a mixture of isologous cells obtained from marrow and from the peritoneal cavity. Under appropriate conditions, homologous or heterologous peritoneal cavity cells, heat-killed cells, or cellfree extracts made from such cells are also effective. The activity of the peritoneal cavity cells or extracts is antigen-specific, in the sense that cells or extracts obtained from animals previously immunized with the test antigen produce much stronger synergistic effects than do cells from animals immunized with some other antigen; however, the peritoneal cavity cells or extracts are not immunogenic when tested in primed animals. The marrow cells, demonstrated to contain precursors of the antibody-forming cells produced during this synergistic immune response, also show a form of antigen-specificity.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000918:Antibody Specificity; D000921:Antibody-Producing Cells; D000941:Antigens; D001853:Bone Marrow / Q000276:immunology*; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D003429:Cross Reactions; D017707:Erythrocyte Transfusion; D005260:Female; D006386:Hemagglutination Tests; D006460:Hemolysin Proteins / Q000032:analysis; D006462:Hemolytic Plaque Technique; D006358:Hot Temperature; D017710:Lymphocyte Transfusion; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity / Q000166:cytology* / Q000276:immunology; D011489:Protein Denaturation; D011828:Radiation Chimera; D051381:Rats; D014020:Tissue Extracts
D000906:Antibodies; D000941:Antigens; D006460:Hemolysin Proteins; D014020:Tissue Extracts