Reduction in the activity of the pancreatic islets induced in normal rodents by prolonged treatment with derivatives of sulfonylurea.
D000818:Animals; D001835:Body Weight; D006224:Cricetinae; D004032:Diet; D005260:Female; D005947:Glucose; D006128:Growth; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000032:analysis / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014044:Tolbutamide / Q000008:administration & dosage / Q000494:pharmacology*
D007004:Hypoglycemic Agents; D007328:Insulin; D014044:Tolbutamide; D005947:Glucose