Peptide bond formation on the ribosome. Structural requirements for inhibition of protein synthesis and of release of peptides from peptidyl-tRNA on bacterial and mammalian ribosomes by aminoacyl and nucleotidyl analogues of puromycin.
D000217:Acyltransferases / Q000032:analysis; D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis*; D001665:Binding Sites; D002247:Carbon Isotopes; D002474:Cell-Free System; D004926:Escherichia coli / Q000166:cytology / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D009705:Nucleosides / Q000494:pharmacology; D009711:Nucleotides / Q000494:pharmacology; D010452:Peptide Biosynthesis; D010649:Phenylalanine / Q000378:metabolism; D010756:Phosphoric Acids / Q000494:pharmacology; D011119:Polynucleotides; D014176:Protein Biosynthesis; D011691:Puromycin / Q000494:pharmacology*; D011770:Pyruvate Kinase; D012333:RNA, Messenger; D012343:RNA, Transfer; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D012270:Ribosomes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism
D000596:Amino Acids; D001426:Bacterial Proteins; D002247:Carbon Isotopes; D009705:Nucleosides; D009711:Nucleotides; D010756:Phosphoric Acids; D011119:Polynucleotides; D012333:RNA, Messenger; D010649:Phenylalanine; D011691:Puromycin; D012343:RNA, Transfer; D014166:Transferases; D000217:Acyltransferases; D011770:Pyruvate Kinase; D007930:Leucine