title: Quantitative nasal culture: a tool in antibiotic research.
abstract: The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Although in previous studies by others cyclacillin was effective in treating mice infected with penicillin G-resistant staphylococci, in the present studies cyclacillin was not effective in suppressing nasal penicillin G-resistant staphylococci in man at doses which markedly suppressed penicillin G-sensitive organisms.
mesh_terms: D000284:Administration, Oral; D002353:Carrier State / Q000188:drug therapy* / Q000382:microbiology; D002986:Clinical Trials as Topic; D003030:Coagulase / Q000096:biosynthesis; D006801:Humans; D008826:Microbial Sensitivity Tests; D009666:Nose / Q000382:microbiology*; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000627:therapeutic use*; D010919:Placebos; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D003030:Coagulase; D010406:Penicillins; D010919:Placebos; D010400:Penicillin G