Smooth muscle antibody in malignant disease.
Smooth muscle antibody at titres of 1/10 or more was found in 54 (67.5%) out of 80 patients with malignant disease and in 9 (20%) out of 46 controls. The incidence of S.M. antibody ranged from 18/30 (60%) in malignant melanoma to 7/8 (83%) in carcinoma of the ovary. The presence of this antibody is possibly related to changes in the malignant cell membrane.A new antibody directed at an antigen presumed to be located in bile canaliculi among other sites is described.
D000230:Adenocarcinoma / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000951:Antigens, Neoplasm; D001323:Autoantibodies / Q000032:analysis*; D001659:Biliary Tract / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology; D001984:Bronchial Neoplasms / Q000276:immunology; D002277:Carcinoma / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008545:Melanoma / Q000276:immunology; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D009447:Neuroblastoma / Q000276:immunology; D010051:Ovarian Neoplasms / Q000276:immunology; D051381:Rats
D000951:Antigens, Neoplasm; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M