title: Release of nuclear DNA template restrictions by specific polyribonucleotides.
abstract: Certain synthetic homo- and copolyribonucleotide polymers are capable of releasing the DNA template restriction of isolated nuclei of rat liver cells when assayed with an excess of or in the absence of exogenous DNA polymerase. The purine homopolyribonucleotides are far more effective than are the pyrimidine polymers.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003597:Cytosine Nucleotides / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D003864:Depression, Chemical; D004926:Escherichia coli / Q000201:enzymology; D006150:Guanine Nucleotides / Q000494:pharmacology; D006358:Hot Temperature; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D009691:Nucleic Acid Denaturation; D011119:Polynucleotides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D013268:Stimulation, Chemical; D013698:Templates, Genetic; D013950:Thymus Gland; D014500:Uracil Nucleotides / Q000494:pharmacology
chemical_list: D000227:Adenine Nucleotides; D003597:Cytosine Nucleotides; D004269:DNA, Bacterial; D006150:Guanine Nucleotides; D011119:Polynucleotides; D012333:RNA, Messenger; D014500:Uracil Nucleotides; D004247:DNA; D004254:DNA Nucleotidyltransferases