title: L-asparaginase induced immunosuppression: inhibition of bone marrow derived antibody precursor cells.
abstract: The cooperation between bone marrow and thymus cells in restoring the hemolytic antibody response to sheep erythrocytes in immunosuppressed recipients was markedly inhibited when donor mice were treated with L-asparaginase, a known inhibitor of lymphocyte function. The marrow cell population was shown to be a major target for the immunosuppressive activity of asparaginase, since thymus cells from enzyme-treated animals interacted with marrow cells from normal animals to generate immunocompetent cells.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001215:Asparaginase / Q000008:administration & dosage / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects* / Q000276:immunology; D001854:Bone Marrow Cells; D004912:Erythrocytes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D051379:Mice; D011830:Radiation Effects; D012756:Sheep; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D001215:Asparaginase