The conversion of proinsulin into insulin in the  -cells of mammals and fishes.
D000818:Animals; D002417:Cattle; D003594:Cytoplasmic Granules / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005399:Fishes; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000378:metabolism*; D007531:Isoflurophate / Q000494:pharmacology; D011384:Proinsulin / Q000378:metabolism*; D051381:Rats; D014357:Trypsin / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D007328:Insulin; D007531:Isoflurophate; D011384:Proinsulin; D014357:Trypsin; D015032:Zinc