Influence of Escherichia coli lipopolysaccharide on histamine-forming capacity and antibody formation in lymphoid tissues.
Mice were injected intraperitoneally with 50 mug of Escherichia coli lipopolysaccharide (LPS). The spleen tissue exhibited increased histamine-forming capacity (HFC) 4 hr later. When this increased HFC was produced within 12 hr after intraperitoneal injection of sheep red blood cells (SRBC), there was an enhanced anti-SRBC antibody response in the spleen. In mice experiencing an increased spleen HFC at 36 hr after injection of SRBC, there was a significant decrease in the number of antibody-producing cells. The injection of histidine decarboxylase inhibitors simultaneously with the LPS greatly reduced the stimulation of HFC and also the adjuvant activity of the LPS.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D002247:Carbon Isotopes; D002262:Carboxy-Lyases / Q000032:analysis / Q000037:antagonists & inhibitors; D004731:Endotoxins / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D006461:Hemolysis / Q000187:drug effects; D006632:Histamine / Q000096:biosynthesis*; D006639:Histidine; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000201:enzymology; D013997:Time Factors
D002247:Carbon Isotopes; D004731:Endotoxins; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; D006639:Histidine; D006632:Histamine; D002262:Carboxy-Lyases