title: Killing of cells in bacterial colonies.
abstract: Bacterial colonies grown on membrane filters and transferred to plates of inhibitor-containing medium decrease in number of total viable colony-forming cells. The decrease in viable cell count occurs in direct proportion to the concentration of inhibitor present and the length of time the colonies are exposed to the inhibitor, suggesting that the kinetics of cell kill approximate a first-order chemical reaction.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001377:Azaserine / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D005472:Fluorouracil / Q000494:pharmacology; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology; D009603:Nitroso Compounds / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D009603:Nitroso Compounds; D002701:Chloramphenicol; D001377:Azaserine; D014508:Urea; D010400:Penicillin G; D005472:Fluorouracil; D008727:Methotrexate