Lymphocytic-choriomeningitis virus in hamster tumor: spread to hamsters and humans.
A passage line of a spontaneous hamster fibrosarcoma is contaminated by the virus. of lymphocytic choriomeningitis. Tumors from animals receiving implants when newborn contain high titers of infectious lymphocytic-choriomeningitis virus and complement-fixing antigen, and hamsters receiving implants when weanlings develop high titers of complement-fixing antibody against lymphocytic-choriomeningitis virus. In contrast with the specific reactions of tumorous hamsters to the initiating virus in virus-induced tumors, the development of complement-fixing antibody to lymphocytic-choriomeningitis virus does not depend on the development of tumors. Infant hamsters bearing the tumor have a generalized subclinical infection and seem able to spread virus to other hamsters and to humans.
D000818:Animals; D000831:Animals, Newborn; D000941:Antigens; D003168:Complement Fixation Tests; D006224:Cricetinae; D005354:Fibrosarcoma / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008216:Lymphocytic Choriomeningitis; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D014780:Viruses / Q000276:immunology*; D014713:Viruses, Unclassified / Q000276:immunology*
D000941:Antigens