The induction of adenomata in mouse lung homografts by chemical carcinogens.
Implants of lung from 18-day-old embryo BALB/c mice of an inbred strain were exposed to 3,4-benz(a)pyrene or 1,2,5,6-dibenzanthracene and introduced subcutaneously into 6-week-old mice of the same strain. Lung adenomata developed within 16 weeks.There was no evidence of an effect of either chemical carcinogen on the subcutaneous tissue of the host animal.
D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D004622:Embryo, Mammalian; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D016040:Lung Transplantation; D008297:Male; D008722:Methods; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010947:Plants, Toxic; D012867:Skin / Q000473:pathology; D012907:Smoking; D014026:Nicotiana; D014184:Transplantation, Homologous
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes