Inhibitor of bacterial growth released by human cells in culture.
Used medium from cultured human cells contains a factor that inhibits growth of the "less virulent" strains of pathogenic bacteria, but only retards growth of the "more virulent" strains. The factor is heat-stable, dialyzable, and unaffected by change in pH; it chromatographs as material of molecular weight between 700 and 1500. There is evidence that this factor is an alpha-ketoaldehyde attached to a carrier.
D000447:Aldehydes / Q000032:analysis / Q000494:pharmacology*; D002850:Chromatography, Gel; D003470:Culture Media; D003864:Depression, Chemical; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*; D006367:HeLa Cells; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000254:growth & development*; D009345:Neisseria meningitidis / Q000187:drug effects / Q000254:growth & development*; D012485:Salmonella typhi / Q000187:drug effects / Q000254:growth & development*; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development*
D000447:Aldehydes; D003470:Culture Media