Drug effects in squirrel monkeys trained on a multiple schedule with a punishment contingency.
The behavior of four monkeys trained on a multiple schedule was differentially sensitive to selected pharmacological agents. The three components of the multiple schedule were: (1) a variable-interval schedule in which responses were reinforced on the average of once per minute; (2) a concurrent schedule in which every tenth response was reinforced and every fifteenth response, on the average, was shocked; and, (3) a neutral stimulus in the presence of which responses were neither reinforced nor shocked. Pentobarbital, chlordiazepoxide, and meprobamate increased responding during each of the components. Scopolamine and d-amphetamine decreased variable-interval performance, had minimal effects on performance during the concurrent-schedule component, and increased responding in the presence of the neutral stimulus. Chlorpromazine decreased variable-interval responding and had slight effects on the responding during the other two components.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology*; D000882:Haplorhini; D008297:Male; D008620:Meprobamate / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology*; D011678:Punishment; D011930:Reaction Time / Q000187:drug effects*; D012055:Reinforcement Schedule; D012054:Reinforcement, Psychology; D012601:Scopolamine / Q000494:pharmacology*; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; D002707:Chlordiazepoxide; D008620:Meprobamate; D012601:Scopolamine; D010424:Pentobarbital; D003913:Dextroamphetamine; D002746:Chlorpromazine