Eperythrozoon coccoides. I. Effect on the interferon response in mice.
Eperythrozoon coccoides is a common blood parasite of rodents and the etiological agent of a chronic infection present in many mouse colonies. After primary infection, mice develop a parasitemia and anemia followed by a chronic, latent infection. During the acute phase of infection, mice manifest a striking suppression of interferon production in response to induction with Newcastle disease virus, Chikungunya virus, and poly I:C. These data suggest that the reticuloendothelial system involvement with this agent is associated with impairment of the interferon response. The enhanced susceptibility of E. coccoides-infected animals to certain viral infections may be related to this suppression of interferon production.
D000818:Animals; D001424:Bacterial Infections / Q000097:blood*; D002646:Chikungunya virus; D004731:Endotoxins / Q000494:pharmacology; D004926:Escherichia coli; D006400:Hematocrit; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000097:blood*; D051379:Mice; D009174:Mycoplasma; D009522:Newcastle disease virus; D009929:Organ Size; D011070:Poly I-C / Q000494:pharmacology; D012376:Rodent Diseases / Q000097:blood / Q000382:microbiology; D013154:Spleen; D013997:Time Factors
D004731:Endotoxins; D007369:Interferon Inducers; D007372:Interferons; D011070:Poly I-C