Human immunity to the meningococcus. V. The effect of immunization with meningococcal group C polysaccharide on the carrier state.
Purified meningococcal polysaccharides were administered to army recruits. No adverse reactions were observed in 145 men who received group C polysaccharide, and in 53 men who were injected with group A polysaccharide. Hemagglutinating and bactericidal activity developed in the sera of all individuals with the exception of two recruits injected with A polysaccharide. During the 6 wk period of observation, the proportion of unvaccinated recruits who acquired group C meningococci in the three companies studied was 38, 42, and 69 per cent. A significantly lower proportion of the individuals vaccinated with group C polysaccharide acquired group C meningococci; 4.6, 24, and 31 per cent respectively.
D000328:Adult; D002353:Carrier State / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006386:Hemagglutination Tests; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000517:prevention & control*; D008889:Military Personnel; D009305:Nasopharynx / Q000382:microbiology; D009345:Neisseria meningitidis / Q000276:immunology*; D009515:New Jersey; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D014612:Vaccines
D011135:Polysaccharides, Bacterial; D014612:Vaccines