Effect of streptomycin on some enzyme systems of Bacillus subtilis.
Streptomycin slightly inhibited lactic and malic dehydrogenases of Bacillus subtilis, and inhibited isocitric dehydrogenase to about 60%. The formation of lactic dehydrogenase, glutamic dehydrogenase, alpha-alanine dehydrogenase, and succinic dehydrogenase was stimulated by the antibiotic at a concentration causing 50% inhibition of bacterial growth. Streptomycin had practically no influence on the formation of malic dehydrogenase, but the antibiotic produced 48% inhibition of the synthesis of isocitric dehydrogenase.
D000409:Alanine; D001412:Bacillus subtilis / Q000187:drug effects* / Q000201:enzymology*; D001431:Bacteriological Techniques; D005969:Glutamate Dehydrogenase / Q000096:biosynthesis; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D007770:L-Lactate Dehydrogenase / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors; D013053:Spectrophotometry; D013307:Streptomycin / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000096:biosynthesis
D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000409:Alanine; D013307:Streptomycin