title: Kinetics and immunoglobulin nature of the antibody response to Mycobacterium tuberculosis.
abstract: Antibody production after injection of Mycobacterium tuberculosis was studied by use of the single cell plaque assay technique. Maximal numbers of antibody-forming cells were found 9 days after a single injection of M. tuberculosis, about 1 day before the appearance of maximal circulating antibody. Immunoelectrophoretic studies and 2-ME studies on 19S and 7S globulin fractions obtained by gel filtration show that the hemagglutination and hemagglutination-lysis antibody activity is associated with 19S immunoglobulin.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D007700:Kinetics; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011817:Rabbits
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008623:Mercaptoethanol