Immunological evidence for the presence of B protein (apoprotein of beta-lipoprotein) in normal and abetalipoproteinemic plasma.
The antigenicity of -lipoprotein that had been chemically altered by acetylation or arsanilation was compared with that of native beta-lipoprotein, of lymph chylomicrons, of plasma proteins with d > 1.21, and of plasma from patients with abetalipoproteinemia. Chemical alteration causes structural changes in beta-lipoprotein which render it immunologically identical with a protein that is present both in normal plasma and in plasma from patients with abetalipoproteinemia. This protein has been identified by immunoelectrophoresis as abeta -globulin which does not stain for lipid. It is presumed to be the lipid-free apoprotein of beta-lipoprotein (B protein). The findings suggest that abetalipoproteinemia is not due to inability to synthesize B protein, but might instead be due to a defect in the formation of the complete beta-lipoprotein macro-molecule.
D000012:Abetalipoproteinemia / Q000276:immunology*; D000293:Adolescent; D001391:Azo Compounds; D001692:Biological Transport; D055598:Chemical Phenomena; D002621:Chemistry; D002648:Child; D002914:Chylomicrons; D005260:Female; D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007223:Infant; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011506:Proteins / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis*; D014461:Ultracentrifugation
D001391:Azo Compounds; D002914:Chylomicrons; D007106:Immune Sera; D008074:Lipoproteins; D011506:Proteins; D012712:Serum Globulins