Restoration of gamma globulin production in agammaglobulinemic chickens.
Chickens irradiated and bursectomized in the newly hatched period consistently develop agammaglobulinemia and form no circulating antibodies; if the birds are treated immediately after operations by intra-abdominal injection of unirradiated autologous bursa cells, immunoglobulin production, lymphoid germinal centers, and plasma cells are restored; however, the birds fail to produce antibody to specific antigenic challenge.
D000361:Agammaglobulinemia / Q000209:etiology*; D000818:Animals; D000917:Antibody Formation; D002003:Brucella abortus; D002060:Bursa of Fabricius / Q000502:physiology* / Q000637:transplantation*; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D066298:In Vitro Techniques; D011200:Poultry; D011830:Radiation Effects; D012710:Serum Albumin, Bovine; D014182:Transplantation, Autologous
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012710:Serum Albumin, Bovine