Immunoglobulin A: localization in rectal mucosal epithelial cells.
Immunofluorescence studies with monospecific antiserums to human serum immunoglobulins consistently revealed immunoglobulin A within the apical portion of the cytoplasm of rectal mucosal epithelial cells in normal subjects, as well as in patients with various bowel diseases. Immunoglobulins M, G, and D were not demonstrated within mucosal epithelial cells. The predominance of lymphoid cells containing immunoglobulin A in the lamina propria of intestinal tissues was confirmed.
D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005455:Fluorescent Antibody Technique; D007070:Immunoglobulin A / Q000032:analysis*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology*; D012007:Rectum / Q000166:cytology / Q000276:immunology*
D007070:Immunoglobulin A