Acute granulomatous response produced in mice by trehalose-6,6-dimycolate.
Trehalose-6,6-dimycolate, a toxic lipid derived from tubercle bacilli, injected intravenously into mice in 10% emulsions of Bayol F caused a three- to fourfold increase in the weights of lungs compared with those of mice injected with emulsions of Bayol F alone or emulsions of Wax D. This change is due to a heavy infiltration of the lungs with granulocytes and large numbers of macrophages, with formation in some of the infiltrates of round foci, resembling granulomas.
D000818:Animals; D004655:Emulsions; D006099:Granuloma / Q000139:chemically induced*; D007275:Injections, Intravenous; D008055:Lipids / Q000008:administration & dosage / Q000633:toxicity*; D008168:Lung / Q000473:pathology; D051379:Mice; D009169:Mycobacterium tuberculosis; D009929:Organ Size; D014376:Tuberculosis / Q000276:immunology*; D014885:Waxes / Q000633:toxicity
D004655:Emulsions; D008055:Lipids; D014885:Waxes