Nonproteolytic, avirulent Bacillus anthracis as a live vaccine.
Fubra, Ernest S. (Federal Department of Veterinary Research, Vom, Nigeria). Nonproteolytic, avirulent Bacillus anthracis as a live vaccine. J. Bacteriol. 91:930-933. 1966.-A nonproteolytic mutant, derived from the Sterne strain of Bacillus anthracis by exposure to ultraviolet radiation, was used for vaccination of guinea pigs. Vaccine prepared from the parent Sterne strain was used in comparable immunization procedure. Comparison of the protection induced by the two vaccines showed that use of the nonproteolytic mutant was from 10 to 1,000 times as effective as the Sterne strain.
D000818:Animals; D001408:Bacillus anthracis; D001428:Bacterial Vaccines; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009154:Mutation
D001428:Bacterial Vaccines