Occurrence and properties of a macroglobulin dimer in some hyperglobulinemic sera.
A 22S human gammaM-globulin component has been subjected to various study. It appears to be a dimer of 19S proteins and can undergo reversible molecular transitions which are both pH and temperature dependent. The 22S material regenerated from its 8S subunits no longer undergo similar transformations. Efforts to demonstrate that the 22S material was an antigen-antibody complex of 19S molecules were unsuccessful. Complex precipitin reactions in gels are given by macroglobulins containing this component with antibody to L chains.
D001796:Blood Protein Disorders; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M; D011233:Precipitin Tests; D012712:Serum Globulins; D014461:Ultracentrifugation; D008258:Waldenstrom Macroglobulinemia
D007075:Immunoglobulin M; D012712:Serum Globulins