Renal erythropoietic factor: role of ions and vasoactive agents in erythropoietin formation.
Evidence is provided for the existence of a renal erythropoietic factor, devoid of vasopressor activity, which upon interaction in vitro with normal serum yields erythropoietin. When undialyzed serum is used, erythropoietin inactivation develops in the incubation mixtures, and this inactivation appears to be dependent on an enzymatic component in preparations of the factor and on ions in serum.
D000818:Animals; D001769:Blood; D001920:Bradykinin / Q000494:pharmacology; D002122:Calcium Chloride / Q000494:pharmacology; D003956:Dialysis; D004492:Edetic Acid; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000096:biosynthesis*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D011086:Polycythemia / Q000503:physiopathology; D051381:Rats; D012083:Renin / Q000494:pharmacology
D004921:Erythropoietin; D004492:Edetic Acid; D012083:Renin; D002122:Calcium Chloride; D001920:Bradykinin