title: Sarcomeric oscillations in frog skeletal muscle fibers.
abstract: Brief asynchronous, small-amplitude, cyclic, longitudinal displacements of the striations of frog skeletal muscle fibers were observed with ordinary light microscopy after application of caffeine and certain quaternary ammonium compounds. With time these oscillations became synchronized and evolved into peristaltic-like movements. The oscillations were influenced by sarcomere length, temperature, external concentration of calcium ions, membrane potential, and disruption of the transverse tubules.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D002110:Caffeine / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004492:Edetic Acid; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006982:Hypertonic Solutions / Q000494:pharmacology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D006982:Hypertonic Solutions; D002110:Caffeine; D013779:Tetrodotoxin; D004492:Edetic Acid; D002118:Calcium; D014403:Tubocurarine