title: Human prothrombin activation.
abstract: Antiserums to human prothrontbin contain antibodies directed against at least two different antigenic sites. During blood coagulation, prothrombin is cleaved into two major antigenically distinct fragments-thrombin and a "pro" fragment. The latter is present in normal seruim, whereas thrombin loses its immunologic reactivity, presumably because of its combination with the natural thrombin inhibitors in blood.
mesh_terms: D000937:Antigen-Antibody Reactions; D001777:Blood Coagulation; D006801:Humans; D007106:Immune Sera; D007120:Immunochemistry; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D011516:Prothrombin
chemical_list: D007106:Immune Sera; D011516:Prothrombin