Biosynthesis of nucleic acid purines in Mycobacterium tuberculosis H37Rv.
1. The biosynthesis of nucleic acid purine in Mycobacterium tuberculosis H(37)R(v) has been studied by using (14)C-labelled precursors. 2. The results indicate that C-2 and C-8 of the purine ring are derived most efficiently from serine and glycine and not from formate. 3. [(14)C]Methionine is not incorporated into the ureide carbon atoms of the purine ring.
D002852:Chromatography, Ion Exchange; D002854:Chromatography, Paper; D005561:Formates / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D066298:In Vitro Techniques; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D009696:Nucleic Acids / Q000096:biosynthesis*; D011687:Purines / Q000096:biosynthesis*; D012694:Serine / Q000378:metabolism
D005561:Formates; D009696:Nucleic Acids; D011687:Purines; D012694:Serine; D005998:Glycine