title: U-21,963, a new antibiotic. I. Discovery and biological activity.
abstract: A new antibiotic, U-21,963, is produced by a new strain of Trichoderma viride. Antibiotic activity can be demonstrated against both gram-positive and gram-negative bacteria and also against a wide variety of fungi. U-21,963 is not cross-resistant with other commonly used antibiotics. U-21,963 afforded no protection against Klebsiella pneumoniae, Streptococcus pyogenes, or Staphylococcus aureus when it was injected subcutaneously into mice.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D003904:Mitosporic Fungi / Q000378:metabolism*; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media