Factor 8 and antibody levels in plasma fractions prepated by cryoprecipitation.
Most of the antibody activity of plasma was found to remain in the supernatant fraction following the preparation of factor-VIII-rich cryoprecipitates. The low level of antibody remaining in these cryoprecipitates indicated that they could safely be used as a source of factor VIII for replacement therapy. Washing the cryoprecipitates farther reduced their antibody titres without materially affecting their factor VIII content.
D000906:Antibodies / Q000032:analysis*; D001803:Blood Transfusion; D011232:Chemical Precipitation; D003080:Cold Temperature; D005169:Factor VIII / Q000032:analysis* / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy; D006801:Humans; D012204:Rh-Hr Blood-Group System
D000906:Antibodies; D012204:Rh-Hr Blood-Group System; D005169:Factor VIII