title: Genetic control of the beta-ketoadipate pathway in Pseudomonas aeruginosa.
abstract: The regulation and genetic control of the beta-ketoadipate pathway in Pseudomonas aeruginosa were investigated. The pattern of enzyme induction is apparently the same as in P. putida. Mutants were obtained for all but 1 of the 11 structural genes; the proximity of these genes on the chromosome was examined by transduction of the mutants with phage F116. If a group of enzymes was induced by the same compounds, the corresponding genes were closely clustered. Surprisingly, some locispecifying enzymes not sharing a common inducer were also clustered. It is suggested that this latter finding may indicate a degree of chromosomal specialization.
mesh_terms: D000272:Adipates / Q000378:metabolism*; D001435:Bacteriophages; D002396:Catechols; D002874:Chromosome Mapping; D002876:Chromosomes, Bacterial; D004950:Esterases / Q000378:metabolism; D005796:Genes; D005827:Genetics, Microbial; D007535:Isomerases / Q000378:metabolism; D007651:Keto Acids; D008967:Molecular Biology; D009154:Mutation; D010101:Oxygen Consumption; D010105:Oxygenases / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000201:enzymology; D014161:Transduction, Genetic; D014166:Transferases / Q000378:metabolism
chemical_list: D000272:Adipates; D002396:Catechols; D007651:Keto Acids; D010105:Oxygenases; D014166:Transferases; D004950:Esterases; D007535:Isomerases