title: Comparative control of a branch-point enzyme in microorganisms.
abstract: Thirty-two genera of microorganisms were identified with one of six distinctive control patterns for the enzyme 3-deoxy-d-arabino-heptulosonate-7-phosphate synthetase. These patterns included sequential feedback inhibition, isoenzyme feedback inhibition, cumulative feedback inhibition, and three (apparent) simple one-effector patterns. Documentation is provided of an overwhelming tendency for control patterns to be strongly conserved among the member species of the various genera that were examined.
mesh_terms: D000192:Actinomycetales / Q000201:enzymology; D000333:Aeromonas / Q000201:enzymology; D062365:Aminobenzoates / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology; D001419:Bacteria / Q000201:enzymology* / Q000254:growth & development; D001565:Benzoates / Q000494:pharmacology; D003470:Culture Media; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D004754:Enterobacter / Q000201:enzymology; D004885:Erwinia / Q000201:enzymology; D004925:Escherichia / Q000201:enzymology; D005246:Feedback; D005658:Fungi / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism; D008025:Ligases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008837:Micrococcus / Q000201:enzymology; D010649:Phenylalanine / Q000494:pharmacology; D011511:Proteus / Q000201:enzymology; D011549:Pseudomonas / Q000201:enzymology; D012475:Salmonella / Q000201:enzymology; D012705:Serratia / Q000201:enzymology; D013291:Streptococcus / Q000201:enzymology; D014364:Tryptophan / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology; D014974:Xanthomonas / Q000201:enzymology
chemical_list: D062365:Aminobenzoates; D001565:Benzoates; D003470:Culture Media; D003509:Cyclohexanecarboxylic Acids; D007527:Isoenzymes; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan; D008025:Ligases