title: Chloroquine: mode of action.
abstract: The drug chloroquine is bactericidal for Bacillus megaterium; it inhibits DNA and RNA biosynthesis and produces rapid degradation of ribosomes and dissimilation of ribosomal RNA. Inhibition of protein synthesis is also observed, evidently as a secondary effect. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine.
mesh_terms: D001410:Bacillus megaterium / Q000187:drug effects*; D001426:Bacterial Proteins / Q000096:biosynthesis*; D002247:Carbon Isotopes; D002738:Chloroquine / Q000494:pharmacology*; D002845:Chromatography; D004269:DNA, Bacterial / Q000096:biosynthesis*; D066298:In Vitro Techniques; D010649:Phenylalanine / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis*; D011874:Radiometry; D014498:Uracil / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002247:Carbon Isotopes; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D010649:Phenylalanine; D014498:Uracil; D002738:Chloroquine