title: Temperature-sensitive mutations in Drosophila melanogaster. 8. The homeotic mutant, ss a40a .
abstract: There exists in Drosophila a class of mutations called "homeotic" that cause changes in determination of the imaginal discs. The homeotic mutant, ss(a40a), was found to have a temperature-sensitive transformation of the arista segment of the antennal complex to a tarsus of the leg. In a selected stock penetrance was complete, so that at 29 degrees C normal aristae were produced, whereas at 17 degrees C complete tarsi developed in all flies. "Temperature-shift" studies revealed a temperature-sensitive period in the third larval instar. The temperature-initiated action of ss(a40a) does not appear to result from a simple wave or gradient of determination passing through the disc. Shifts up during the temperature-sensitive period yielded leg tissue proximally, which increased distally with progressively later shifts. Shifts down yielded leg tissue at the aristal base, which retreated with later shifts.
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000033:anatomy & histology* / Q000254:growth & development; D007866:Leg / Q000033:anatomy & histology; D008855:Microscopy, Electron, Scanning; D009154:Mutation; D010641:Phenotype; D013696:Temperature