Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes.
Azide and, to a lesser extent, cyanide inhibit the microbicidal activity of myeloperoxidase and of intact normal leukocytes, but they have little or no effect on peroxidase-negative leukocytes. The contribution of the azide-sensitive (peroxidase-dependent?) systems to the total microbicidal activity of normal leukocytes is considerable. The azide-insensitive antimicrobial systems are more highly developed in peroxidase-negative leukocytes than in normal leukocytes, thus suggesting an adaptation.
D001386:Azides / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002908:Chronic Disease; D003486:Cyanides / Q000494:pharmacology*; D006099:Granuloma / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood; D007239:Infections / Q000097:blood; D007779:Lactobacillus acidophilus / Q000187:drug effects*; D007962:Leukocytes / Q000201:enzymology*; D008199:Lymphadenitis / Q000097:blood; D008297:Male; D008661:Metabolism, Inborn Errors; D010544:Peroxidases / Q000037:antagonists & inhibitors* / Q000097:blood*; D013210:Staphylococcus / Q000187:drug effects*
D001386:Azides; D003486:Cyanides; D006861:Hydrogen Peroxide; D010544:Peroxidases