Plasmodium falciparum in owl monkeys: drug resistance and chloroquine binding capacity.
Erythrocytes infected with chloroquine-sensitive Plasmodium falciparum bind chloroquine with an apparent intrinsic association constant of 1.5 x 10(7) liters per mole. Such high-affinity binding of chloroquine is absent or deficient in uninfected erythrocytes and in erythrocytes infected with chloroquine-resistant Plasmodium falciparum.
D000818:Animals; D002247:Carbon Isotopes; D002738:Chloroquine / Q000097:blood / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D004912:Erythrocytes / Q000382:microbiology*; D000882:Haplorhini; D008288:Malaria / Q000097:blood* / Q000188:drug therapy; D008992:Monkey Diseases; D010963:Plasmodium falciparum; D011955:Receptors, Drug; D013045:Species Specificity
D002247:Carbon Isotopes; D011955:Receptors, Drug; D002738:Chloroquine