title: Thyroid-stimulating hormone response to synthetic thyrotrophin releasing hormone in man.
abstract: Synthetic thyrotrophin-releasing hormone, L-pyroglutamyl-L-histidyl-L-proline-amide, has been administered intravenously to euthyroid subjects in doses ranging from 1 to 200 mug. Its effect was assessed by serial measurements of serum thyroid-stimulating hormone (T.S.H.). A rise in serum T.S.H. was detectable five minutes after administration of 50 mug. of thyrotrophin-releasing hormone, reaching a maximum in 15 to 30 minutes, and then gradually declining over the next 120 minutes. Doses of 100 and 200 mug. of thyrotrophin-releasing hormone produced even greater rises of T.S.H. in some cases. The only side-effect noted was transient nausea with doses greater than 50 mug. Measurement of serum T.S.H. levels after administration of thyrotrophin-releasing hormone should prove a useful test of pituitary T.S.H. release and may help to distinguish pituitary and hypothalamic lesions.
mesh_terms: D000328:Adult; D001798:Blood Proteins; D006801:Humans; D007118:Immunoassay; D007455:Iodine / Q000097:blood; D008297:Male; D010901:Pituitary Function Tests; D011485:Protein Binding; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001798:Blood Proteins; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007455:Iodine