Mode of action of 2-nitro-1-butyl pyridinium sulfate.
Ten micrograms of 2-nitro-1-butyl pyridinium sulfate (NBPS) per milliliter inhibited the growth of Bacillus subtilis by blocking thymidylate synthetase. The inhibition could be reversed by the addition of thymine or cytosine.
D001412:Bacillus subtilis / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D002247:Carbon Isotopes; D003596:Cytosine / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D008025:Ligases / Q000378:metabolism; D010101:Oxygen Consumption; D011726:Pyridinium Compounds / Q000494:pharmacology*; D013431:Sulfates; D013937:Thymidine Kinase / Q000378:metabolism; D013941:Thymine / Q000378:metabolism
D002247:Carbon Isotopes; D004269:DNA, Bacterial; D011726:Pyridinium Compounds; D013431:Sulfates; D003596:Cytosine; D013937:Thymidine Kinase; D008025:Ligases; D013941:Thymine