Cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus.
Lymphocytic choriomeningitis virus, strain E-350, when inoculated intracerebrally in rats 1 to 7 days old, produces an acute destructive infection of the cerebellar cortex resulting in permanent cerebellar hypoplasia and ataxia. Several other arenoviruses may produce a similar lesion in neonatal rodents.
D000818:Animals; D000831:Animals, Newborn; D001259:Ataxia / Q000209:etiology; D002525:Cerebellar Cortex / Q000473:pathology*; D002526:Cerebellar Diseases / Q000209:etiology*; D003711:Demyelinating Diseases; D008216:Lymphocytic Choriomeningitis / Q000150:complications* / Q000473:pathology; D008217:Lymphocytic choriomeningitis virus / Q000472:pathogenicity; D009336:Necrosis; D051381:Rats; D014713:Viruses, Unclassified / Q000472:pathogenicity*