Serum-alpha2-macroglobulin, transferrin, albumin, and IgG levels in preeclampsia.
A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls, but there are significant falls in alpha(2)-macroglobulin and IgG. When preeclampsia is accompanied by proteinuria there is a marked fall in albumin and an increase in alpha(2)-macroglobulin. Since alpha(2)-macroglobulin has antiplasmin activity it is possible that increased levels of this protein in preeclampsia accompanied by proteinuria contribute to the intravascular coagulation which has been described in this disorder.
D000293:Adolescent; D000328:Adult; D000933:Antifibrinolytic Agents; D001777:Blood Coagulation; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D008259:Macroglobulins / Q000032:analysis*; D011225:Pre-Eclampsia / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011507:Proteinuria / Q000150:complications; D012709:Serum Albumin / Q000032:analysis*; D014168:Transferrin / Q000032:analysis*
D000933:Antifibrinolytic Agents; D007074:Immunoglobulin G; D008259:Macroglobulins; D012709:Serum Albumin; D014168:Transferrin