title: Variation and homology in the mu and gamma heavy chains of human immunoglobulins.
abstract: Sequence analysis of an 1gM immunoglobulin shows that the variable regions of hunman micro and gamma1 heavy chainis may have twice as much homology as their constant regions and that evolutionary divergence of micro and gamma1 heavy chain genes occurred not long after the separation of heavy and light chain genes.
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis; D008258:Waldenstrom Macroglobulinemia / Q000097:blood
chemical_list: D007075:Immunoglobulin M; D007136:Immunoglobulins