Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants.
Although variants of sialic acid-free alpha(1)-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of alpha(1)-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes alpha(1)-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.
D000818:Animals; D000937:Antigen-Antibody Reactions; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004586:Electrophoresis; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006023:Glycoproteins; D006801:Humans; D005779:Immunodiffusion; D009439:Neuraminidase; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011817:Rabbits; D014310:Triplets; D014427:Twins
D006023:Glycoproteins; D009439:Neuraminidase