Antibacterial activity of dihydro-1,3-oxazine derivatives condensed with aromatic rings in positions 5,6.
1. The antibacterial activity in vitro of dihydro-1,3-oxazine derivatives with aromatic rings condensed in positions 5, 6 was examined.2. Of more than thirty compounds examined, two (T 615 and T 638) showed marked activity against various strains of Mycobacterium tuberculosis at concentrations below 2 mug/ml.3. These two compounds also showed marked activity against Escherichia coli, Clostridium pneumoniae and Salmonella typhi.4. Both showed marked activity in vivo against tuberculosis produced in mice and guinea-pigs by various strains of Mycobacterium such as human strain ;Sz', bovine ;An 5' and H37Rv non-resistant and resistant to isonicotinic acid hydrazide (INH), streptomycin (SM) and p-aminosalicylic acid (PAS).
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006168:Guinea Pigs; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010078:Oxazines / Q000494:pharmacology* / Q000633:toxicity; D012485:Salmonella typhi / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D010078:Oxazines