Biologicl activity and synthesis of an encephalitogenic determinant.
A 45-residue fragment of the basic protein of myelin is encephalitogenic in the rabbit and monkey but relatively inactive in the guinea pig. Synthetic peptides containing the sequence of a tryptic peptide of the fragment Thr-Thr-His-Tyr-Gly-Ser-Leu-Pro-Gln-Lys are moderately encephalitogenic.
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000473:pathology; D002490:Central Nervous System / Q000473:pathology; D004660:Encephalitis / Q000139:chemically induced* / Q000473:pathology; D006168:Guinea Pigs; D000882:Haplorhini; D009419:Nerve Tissue Proteins / Q000138:chemical synthesis*; D010455:Peptides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000633:toxicity; D011817:Rabbits
D009419:Nerve Tissue Proteins; D010455:Peptides