Chromomycin A 3 , an antitumor antibiotic: tissue distribution studies in mice as measured by microbial assay.
A microbiological assay has been developed for chromomycin A(3), an antitumor antibiotic showing promise in human trials. The assay bacterium is a derived strain of Streptococcus faecalis resistant to methotrexate. Studies with mice revealed that relatively high concentrations of this antibiotic were maintained in the blood, kidneys, and liver of mice after a single-dose intraperitoneal injection of the drug.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood / Q000494:pharmacology / Q000652:urine; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D003124:Colorimetry; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000032:analysis*; D008099:Liver / Q000032:analysis*; D008297:Male; D008722:Methods; D008727:Methotrexate / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains
D000903:Antibiotics, Antineoplastic; D008727:Methotrexate