title: Synthesis and biological activity of tricyclic antifolate compounds with fixed geometry.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy; D002460:Cell Line; D002645:Chickens; D013293:Enterococcus faecalis / Q000187:drug effects; D005493:Folic Acid Antagonists / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008099:Liver / Q000201:enzymology; D008288:Malaria / Q000188:drug therapy; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D051379:Mice; D009062:Mouth Neoplasms / Q000188:drug therapy; D011739:Pyrimethamine / Q000494:pharmacology; D011799:Quinazolines / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D011799:Quinazolines; D011739:Pyrimethamine