title: Pulmonary absorption and retention of kanamycin after repeated inhalation administration of kanamycin aerosol.
abstract: The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 mug/g and 3.52 mug/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.
mesh_terms: D000042:Absorption; D000336:Aerosols; D000362:Agar; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D001681:Biological Assay; D004058:Diffusion; D007612:Kanamycin / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007668:Kidney / Q000032:analysis; D008168:Lung / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D000336:Aerosols; D007612:Kanamycin; D000362:Agar