title: Discussion paper: amethopterin linked covalently to water-soluble macromolecules.
mesh_terms: D000818:Animals; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D007780:Lacticaseibacillus casei / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy; D046911:Macromolecular Substances; D008727:Methotrexate / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D011108:Polymers / Q000494:pharmacology / Q000627:therapeutic use; D011485:Protein Binding; D012709:Serum Albumin; D012995:Solubility; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship; D013997:Time Factors; D014461:Ultracentrifugation; D014466:Ultraviolet Rays; D014867:Water
chemical_list: D046911:Macromolecular Substances; D011108:Polymers; D012709:Serum Albumin; D014867:Water; D008727:Methotrexate