Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin.
Trehalose-6,6-dimycolate (cord factor), a glycolipid from mycobacteria, suppressed the development of urethan-induced tumors in the lungs of mice to a similar degree as living Mycobacterium bovis (strain BCG) bacilli. The inhibition was apparently due to the host cellular reaction caused locally by cord factor.
D000236:Adenoma / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D006017:Glycolipids / Q000302:isolation & purification / Q000627:therapeutic use*; D006099:Granuloma / Q000209:etiology; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000032:analysis*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014520:Urethane
D001500:BCG Vaccine; D006017:Glycolipids; D014520:Urethane