title: Therapeutic innovation: ethical boundaries in the initial clinical trials of new drugs and surgical procedures.
mesh_terms: D000818:Animals; D004285:Dogs; D004358:Drug Therapy; D004992:Ethics, Medical; D006805:Human Experimentation; D006801:Humans; D007114:Immunization; D011781:Quackery / Q000494:pharmacology; D051381:Rats; D013514:Surgical Procedures, Operative; D014180:Transplantation