Genetic control of immunological responsiveness in guinea pigs to 2,4-dinitrophenyl conjugates of poly-L-arginine, protamine, and poly-L-ornithine.
The ability of guinea pigs to respond immunologically to dinitrophenyl (DNP)-poly-L-arginine, DNP-protamine, DNP polyornithine, and to unsubstituted poly-L-arginine and protamine is linked to the presence of the poly-L-lysine gene. This gene has previously been demonstrated to control the immune response of guinea pigs to poly-L-lysine, to a copolymer of L-glutamic acid and L-lysine and to haptenic derivatives of these materials. Although the ability to respond to each of these highly charged compounds is linked to the presence of the poly-L-lysine gene, the cellular immune responses to these antigens is highly individually specific.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D001120:Arginine; D046508:Culture Techniques; D004247:DNA / Q000096:biosynthesis; D004140:Dinitrophenols; D005799:Genes, Dominant; D006168:Guinea Pigs; D006241:Haptens / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed; D008198:Lymph Nodes / Q000378:metabolism; D008239:Lysine; D009161:Mycobacterium / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000276:immunology; D009952:Ornithine; D010455:Peptides / Q000494:pharmacology*; D011479:Protamines / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism
D000941:Antigens; D004140:Dinitrophenols; D006241:Haptens; D010455:Peptides; D011479:Protamines; D004247:DNA; D001120:Arginine; D009952:Ornithine; D008239:Lysine; D013936:Thymidine