Agglutination of platelets by a serum factor in the presence of EDTA.
The platelets of a patient with reticulum-cell sarcoma were found to exhibit agglutination and cytopathic changes when her blood was treated with EDTA but not with other anticoagulants. Investigation showed that the phenomenon was caused by a serum factor that was probably an antibody.
D000368:Aged; D000371:Agglutination; D001323:Autoantibodies; D001792:Blood Platelets / Q000187:drug effects*; D002951:Citrates / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology*; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology*; D008854:Microscopy, Electron; D010437:Peptic Ulcer / Q000276:immunology
D001323:Autoantibodies; D002951:Citrates; D006493:Heparin; D004492:Edetic Acid