Teratogenic effects of a chelating agent and their prevention by zinc.
Ingestion of a chelating agent (ethylenediaminetetraacetic acid) by female rats during pregnancy impaired reproduction and resulted in congenitally malformed young. When ethylenediaminetetraacetic acid was fed from days 6 to 21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous supplementation with 1000 parts per million of dietary zinc.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D002614:Chelating Agents; D004492:Edetic Acid; D005260:Female; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D015032:Zinc / Q000494:pharmacology*
D002614:Chelating Agents; D004492:Edetic Acid; D015032:Zinc