title: Induction of helical arrays of ribosomes by vinblastine sulfate in Escherichia coli.
abstract: Physiological concentrations of vinblastine sulfate elicited ribosomal helices in large numbers in growing cultures of the osmotically sensitive mutant sud 24 and, after treatment with ethylenediaminetetraacetate, also in the K-12 strain. The helices were usually seen at the division plane and were often connected to the membrane. This method of induction of ribosomal helices offers a unique system for studying in vivo structure and function of the translational apparatus in relation to other cell components.
mesh_terms: D002455:Cell Division; D004492:Edetic Acid / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D008854:Microscopy, Electron; D009154:Mutation; D012270:Ribosomes / Q000187:drug effects*; D014747:Vinblastine / Q000494:pharmacology*
chemical_list: D014747:Vinblastine; D004492:Edetic Acid