title: The roles of early alert and of adjuvant in the control of Hong Kong influenza by vaccines.
abstract: The major antigenic changes in influenza A virus that occur at 10-year intervals reduce the effectiveness of existing vaccines and pose a problem for the control of pandemics by vaccination. These difficulties may be obviated in two ways. First, by detecting the emergence of a new variant sufficiently ahead of its general spread for it to be possible to produce a corresponding vaccine in good time; the World Health Organization is widely depended upon for this early warning. Secondly, by the improvement of existing vaccines to increase and broaden their antigenicity; here, their modification by, for instance, adjuvant 65 may contribute significantly.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000882:Haplorhini; D006801:Humans; D007252:Influenza Vaccines / Q000627:therapeutic use*; D007251:Influenza, Human / Q000517:prevention & control*; D013997:Time Factors; D014611:Vaccination; D014944:World Health Organization
chemical_list: D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines