New water disinfectant: an insoluble quaternary ammonium resin-triiodide combination that releases bactericide on demand.
Strongly basic anion-exchange resins form stable, water-insoluble combinations with triiodide ions. The combinations have remarkable antibacterial properties: 3.0 x 10(5)Escherichia coli cells per ml were killed when passed through a 3.8-g column of commercially available resin treated with triiodide (volume 4 ml after treatment). In an attempt to deplete the resin-triiodide complex, 1.14 x 10(9)E. coli cells in 15 liters were passed through the column with no significant loss of effectiveness. The antibacterial capabilities of the resin-triiodide columns ranged from 10(6)Salmonella typhimurium per ml to 1.1 x 10(4)Streptococcus faecalis per ml. Staphylococcus aureus and Pseudomonas aeruginosa were also tested and killed at concentrations of 1.8 x 10(4) and 1.3 x 10(5) per ml, respectively. The cells were not filtered from the water. They emerged from the column in nonviable form. This was demonstrated by using (14)C-labeled bacteria. The irreversible nature of the antibacterial action was revealed when attempts to wash the damaged cells did not restore viability.
D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques; D002247:Carbon Isotopes; D004202:Disinfectants / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D007454:Iodides / Q000494:pharmacology*; D007475:Ion Exchange Resins / Q000494:pharmacology*; D008722:Methods; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013242:Sterilization; D013291:Streptococcus / Q000187:drug effects; D014867:Water
D002247:Carbon Isotopes; D004202:Disinfectants; D007454:Iodides; D007475:Ion Exchange Resins; D014867:Water