title: Camptothecin inhibits macromolecular synthesis in mammalian cells but not in isolated mitochondria of E. coli.
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002247:Carbon Isotopes; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis*; D004269:DNA, Bacterial / Q000096:biosynthesis; D004492:Edetic Acid; D004926:Escherichia coli / Q000378:metabolism*; D005944:Glucosamine / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis; D006367:HeLa Cells / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D008070:Lipopolysaccharides / Q000096:biosynthesis; D008223:Lymphoma; D008660:Metabolism / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014529:Uridine / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002247:Carbon Isotopes; D004269:DNA, Bacterial; D006023:Glycoproteins; D008070:Lipopolysaccharides; D014316:Tritium; D012313:RNA; D004247:DNA; D004492:Edetic Acid; D007930:Leucine; D005944:Glucosamine; D013936:Thymidine; D014529:Uridine