Pulmonary absorption and retention of kanamycin after repeated inhalation administration of kanamycin aerosol.
The absorption and retention of kanamycin by the pulmonary system was evaluated after aerosol administration to rats. Tissue level concentrations of the drug were assayed by the agar-plate bioassay method. Mean concentrations of 6.58 mug/g and 3.52 mug/g were found in the lung and kidney homogenates, respectively, 26 hr after the final exposure period. No detectable level was found in the plasma.
D000042:Absorption; D000336:Aerosols; D000362:Agar; D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D001681:Biological Assay; D004058:Diffusion; D007612:Kanamycin / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D007668:Kidney / Q000032:analysis; D008168:Lung / Q000032:analysis / Q000378:metabolism*; D008297:Male; D051381:Rats
D000336:Aerosols; D007612:Kanamycin; D000362:Agar