Pulmonary hemorrhage in hamsters after exposure to proteolytic enzymes of Bacillus subtilis.
Single exposures of Syrian hamsters by aerosol inhalation or intratracheal instillation to proteolytic enzymes of Bacillus subtilis produced massive pulmonary hemorrhage within the first week. Of 46 animals exposed, eight died as a result of extensive hemorrhage. The remainder made uneventful recovery with no apparent residual pulmonary disease 6 weeks after exposure.
D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology*; D006224:Cricetinae; D003902:Detergents; D004342:Drug Hypersensitivity; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced; D010447:Peptide Hydrolases; D012130:Respiratory Hypersensitivity; D013997:Time Factors
D003902:Detergents; D010447:Peptide Hydrolases