Anomalous urinary proteins in patients with serum M-components.
Abnormal urinary proteins were investigated in 365 patients with serum M-components; 250 urines were available for study. All specimens were concentrated and processed by electrophoresis and immunoelectrophoresis. An overall frequency of Bence Jones proteinuria was found in 63%, whereas other M-components were detected in 18%. In patients with multiple myeloma, Bence Jones proteinuria occurred in 71%, while M-components in the form of whole molecules of immunoglobulins or as Fc and F'c fragments were observed in 20%. Bence Jones globulin was found in 60% of patients with IgG myeloma, 69% of those with IgA myeloma and 100% of patients with IgD myeloma and light chain disease. In regard to other diseases, Bence Jones proteinuria was found in 44% of patients with macroglobulinemia, in 60% of patients with nonplasmacytic neoplastic diseases and in 28% of patients with non-malignant conditions. Other M-components were detected in the urine of 13%, 14% and 6% respectively.The detection of abnormal urinary proteins in patients with M-components in the serum is an important diagnostic tool and may have prognostic significance.
D001536:Bence Jones Protein / Q000032:analysis; D006801:Humans; D007122:Immunoelectrophoresis; D007075:Immunoglobulin M / Q000652:urine*; D007136:Immunoglobulins / Q000652:urine; D007938:Leukemia / Q000652:urine*; D008223:Lymphoma / Q000652:urine*; D009101:Multiple Myeloma / Q000652:urine*; D011507:Proteinuria / Q000209:etiology; D008258:Waldenstrom Macroglobulinemia / Q000652:urine*
D007075:Immunoglobulin M; D007136:Immunoglobulins; D001536:Bence Jones Protein