title: Empirical vs. rational approaches in cancer chemotherapy.
mesh_terms: D000818:Animals; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000201:enzymology; D005492:Folic Acid / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D005493:Folic Acid Antagonists; D007942:Leukemia, Experimental / Q000188:drug therapy; D008780:Methyltransferases / Q000037:antagonists & inhibitors; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy*; D013942:Thymine Nucleotides; D014500:Uracil Nucleotides
chemical_list: D005493:Folic Acid Antagonists; D013942:Thymine Nucleotides; D014500:Uracil Nucleotides; D005492:Folic Acid; D008780:Methyltransferases