Cytotoxic and mutagenic activation of urethane by N-hydroxylation and O-esterification.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D003434:Crossing Over, Genetic; D004331:Drosophila melanogaster; D004952:Esters / Q000378:metabolism; D005804:Genes, Lethal; D005808:Genes, Recessive; D006900:Hydroxylation; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D012730:Sex Chromosomes; D013094:Spermatozoa / Q000187:drug effects / Q000254:growth & development; D013329:Structure-Activity Relationship; D013737:Testis / Q000187:drug effects; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology*
D000085:Acetates; D000970:Antineoplastic Agents; D004952:Esters; D009153:Mutagens; D014520:Urethane