title: Thyrotropin secretion in rats after hypothalamic electrical stimulation or injection of synthetic TSH-releasing factor.
abstract: Plasma thyroid-stimulating hormone (TSH) levels, as measured by radioimmunoassay, begin to rise within 5 minutes after initiation of electrical stimulation of the medial-basal hypothalamus, become significantly elevated at 10 minutes, and reach a peak at 10 to 25 minutes. Intravenous administration of synthetic thyrotropin-releasing factor induces a marked rise in plasma thyroidstimulating hormone which is maximal within 5 minutes after administration. These data are interpreted to indicate that there are neuronal structures within the medial-basal hypothalamus which release preformed thyrotropin-releasing factor. The claim (based on bioassay data) that pyroglutamyl-histidyl-proline amide is a potent thyrotropin-releasing factor has also been confirmed by using a highly specific immunoassay system.
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D007031:Hypothalamus / Q000502:physiology*; D011863:Radioimmunoassay; D051381:Rats; D013972:Thyrotropin / Q000097:blood* / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000138:chemical synthesis / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin