Aging of alpha-crystallins during development of the lens.
Fetal alpha-crystallin from the bovine lens can be resolved into three major subunit fractions by ion exchange chromatography. A fourth subunit gradually arises during the development of the lens. Incorporation studies indicate that this subunit is not formed by de novo synthesis but by the chemical conversion of one subunit into another. Possible mechanisms for this conversion are discussed.
D000375:Aging; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002247:Carbon Isotopes; D002417:Cattle; D002852:Chromatography, Ion Exchange; D003459:Crystallins / Q000032:analysis*; D005779:Immunodiffusion; D007908:Lens, Crystalline / Q000196:embryology*
D000596:Amino Acids; D002247:Carbon Isotopes; D003459:Crystallins