title: Changes in gut flora after cephalexin treatment.
abstract: Eighteen patients with urinary tract infection were treated with cephalexin orally. Absorption was variable, between 29 and 89% of the total daily dose being excreted in the urine in 24 hours. A significant number of patients became faecal carriers of Pseudomonas aeruginosa compared with a control group who received no antibiotics. Four of the cephalexin-treated patients acquired a strain of Ps. aeruginosa known to be present in food from the hospital diet kitchen and one developed a urinary tract infection with this strain.
mesh_terms: D000368:Aged; D002511:Cephalosporins / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use / Q000652:urine; D004064:Digestive System / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification* / Q000472:pathogenicity; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D002511:Cephalosporins