The genesis of glomerulonephritis in renal transplants.
It appears that in human renal isografts glomerulonephritis in the transplant may be a recurrence of the original disease. In the allograft, nephritis may be either recurrence, an intrinsic part of the rejection process itself, or acquisition de novo of the disease. A number of parallels to both antiglomerular basement membrane disease and circulating antigen-antibody complex disease in the animal model are suggested, but with the possible exception of an occasional demonstration of anti-GBM disease, proof that such mechanisms operate in the glomerulonephritis developing in the human allograft is at present lacking.
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001323:Autoantibodies; D001485:Basement Membrane / Q000276:immunology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005337:Fibrin; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000150:complications* / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation; D012008:Recurrence; D013291:Streptococcus / Q000276:immunology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014777:Virus Diseases / Q000150:complications / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D000961:Antilymphocyte Serum; D001323:Autoantibodies; D005337:Fibrin