Bacterial inactivation of transforming deoxyribonucleate.
Competent and noncompetent bacteria are able to bind deoxyribonucleate (DNA). The consequence of this binding is different for the two types of bacteria. Competent bacteria are able to utilize the DNA for transformation. DNA exposed to noncompetent bacteria loses its biological activity with a coincident reduction in the double-stranded molecular weight. The reduction in molecular weight does not appear to be sufficient to account for the loss of biological activity observed.
D001412:Bacillus subtilis; D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D004269:DNA, Bacterial / Q000302:isolation & purification; D003973:Diatrizoate; D005827:Genetics, Microbial; D008970:Molecular Weight; D010759:Phosphorus Isotopes; D012260:Ribonucleases; D012483:Salmonella Phages; D013395:Sucrose; D013941:Thymine; D014170:Transformation, Genetic
D002247:Carbon Isotopes; D004269:DNA, Bacterial; D010759:Phosphorus Isotopes; D003973:Diatrizoate; D013395:Sucrose; D012260:Ribonucleases; D013941:Thymine