Clinical significance of 7s IgM in monoclonal IgM diseases.
The sera from 117 patients with diseases associated with a high production of monoclonal IgM were analysed for the presence of low molecular weight (7s) IgM by using a simple thin-layer Sephadex technique. 7s IgM was found in the sera of patients with myelomata (66%), lymphomata (45%), and Waldenström's macroglobulinaemia (20%), but was absent from the sera of patients with benign monoclonal macroglobulinaemia.This technique provides a cheap and practical test which may be valuable in selecting patients with lymphomata from those with benign lesions.
D000328:Adult; D001536:Bence Jones Protein / Q000032:analysis; D002855:Chromatography, Thin Layer; D003911:Dextrans; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008223:Lymphoma / Q000097:blood*; D008722:Methods; D008970:Molecular Weight; D009101:Multiple Myeloma / Q000097:blood*; D011507:Proteinuria / Q000150:complications; D008258:Waldenstrom Macroglobulinemia / Q000097:blood*
D003911:Dextrans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D001536:Bence Jones Protein