Sulfatide synthesis: inhibition by experimental allergic encephalomyelitis serum.
The rate of (35)S incorporation into cerebroside sulfate in cultures of embryo mouse spinal cord shows a rapid acceleration at the time of myelin formation. Exposure of cultures to dilute serum from rabbits with experimental allergic encephalomyelitis results in almost complete inhibition of sulfatide synthesis. Within 24 hours after replacement of inhibiting medium with normal medium there is an increase in sulfatide synthesis followed by myelination.
D000818:Animals; D001345:Autoradiography; D002554:Cerebrosides / Q000096:biosynthesis*; D046508:Culture Techniques; D004622:Embryo, Mammalian; D004679:Encephalomyelitis / Q000097:blood*; D051379:Mice; D013116:Spinal Cord / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000032:analysis / Q000096:biosynthesis; D013460:Sulfur Isotopes; D013997:Time Factors
D002554:Cerebrosides; D013431:Sulfates; D013433:Sulfoglycosphingolipids; D013460:Sulfur Isotopes