Mutants of the biological clock in Chlamydomonas reinhardi.
A genetic analysis of the biological clock in Chlamydomonas reinhardi has been initiated. Of six wild-type strains tested (3 mt(+) and 3 mt(-)), five had periods close to 24 hr whereas one had a 21-hr period. Mutants with altered clock period have been isolated. The periods of 3 of these variant strains are temperature compensated. Genetic crosses involving a long-period mutant suggest that a single gene confers the long-period character, and in general clock-period length seems to be a useful phenotypic measure of alterations in the clock due to genetic differences. One phase mutant was found but its behavior was variable and the phase of the rhythm, relative to a light-dark transition which initiates the rhythm, does not seem to be reliable as a parameter of clock differences. No markers have yet been mapped.
D001683:Biological Clocks; D002465:Cell Movement; D002696:Chlamydomonas; D000460:Chlorophyta; D002940:Circadian Rhythm; D003433:Crosses, Genetic; D005838:Genotype; D008722:Methods; D009154:Mutation / Q000187:drug effects; D009604:Nitrosoguanidines / Q000494:pharmacology; D010641:Phenotype; D010775:Photic Stimulation; D013696:Temperature; D013997:Time Factors
D009604:Nitrosoguanidines