Growth retardation in offspring of female rats treated with morphine prior to conception.
Treatment of female rats with morphine sulfate for 5(1/2) or 10 days, prior to drug withdrawal for 5 days and subsequent mating, results in retarded growth of offspring. The effect is not present at birth but appears at 3 to 4 weeks of age. It occurs even though offspring are not exposed to morphine in utero or postnatally. It is not eliminated by cross-fostering and is apparently of prenatal origin
D000367:Age Factors; D000818:Animals; D001835:Body Weight; D005260:Female; D005306:Fertilization; D006130:Growth Disorders / Q000139:chemically induced*; D008297:Male; D009020:Morphine / Q000008:administration & dosage; D011247:Pregnancy; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
D009020:Morphine