The effect of lymphocytes from sufferers from recurrent aphthous ulceration upon colon cells in tissue culture.
The release of (51)Cr from labelled colon cells was used to assess a possible lymphocytotoxic effect of peripheral blood lymphocytes from patients suffering from recurrent aphthous ulceration. No significant (p > 0.03) difference was observed between the isotope release following incubation with patients' or control lymphocytes. The absence of such a lymphocytotoxic effect, detectable with oral epithelial cells, is discussed in relation to the role of cellular hypersensitivity in the pathogenesis of ulcerative colitis and aphthous ulceration.
D000328:Adult; D000937:Antigen-Antibody Reactions; D002859:Chromium Isotopes; D003093:Colitis, Ulcerative / Q000276:immunology; D003106:Colon / Q000276:immunology* / Q000473:pathology; D003165:Complement System Proteins; D046508:Culture Techniques; D003601:Cytotoxicity Tests, Immunologic; D004848:Epithelium / Q000276:immunology; D005260:Female; D006801:Humans; D006967:Hypersensitivity; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000276:immunology; D013281:Stomatitis, Aphthous / Q000276:immunology*
D002859:Chromium Isotopes; D003165:Complement System Proteins