Ethanol produces muscle damage in human volunteers.
Repeated administration of ethanol (42 percent of total calories) for 28 days increased serum creatine phosphokinase activity and produced ultrastructural changes in skeletal muscle of human volunteers. The data suggest that alcoholic myopathy results from ethanol toxicity, rather than from nutritional or other factors.
D000328:Adult; D001706:Biopsy; D003402:Creatine Kinase / Q000097:blood; D004032:Diet; D000431:Ethanol / Q000494:pharmacology / Q000633:toxicity*; D006003:Glycogen; D006801:Humans; D008055:Lipids; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron; D008928:Mitochondria; D009132:Muscles / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D012519:Sarcoplasmic Reticulum
D008055:Lipids; D000431:Ethanol; D006003:Glycogen; D003402:Creatine Kinase