Cytochalasin B: inhibition of D-2-deoxyglucose transport into leukocytes and fibroblasts.
Cytochalasin B inhibits transport of (D)-2-deoxyglucose and of glucosamine into kukocytes, but does not impair uptake of kucine by these cells. This inhibitory action is rapid and reversible, and results in suppression of glycolysis. Cytochalasin B also blocks transport of (D)-2-deoxyglucose, but not of leucine, into mouse L strain fibroblasts.
D000818:Animals; D001345:Autoradiography; D002247:Carbon Isotopes; D005944:Glucosamine / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006601:Hexoses / Q000378:metabolism*; D006736:Horses; D007700:Kinetics; D007739:L Cells / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D007930:Leucine / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism*; D051379:Mice; D009183:Mycotoxins / Q000494:pharmacology*; D014316:Tritium
D002247:Carbon Isotopes; D006601:Hexoses; D007773:Lactates; D009183:Mycotoxins; D014316:Tritium; D007930:Leucine; D005944:Glucosamine