Feeding produced in the satiated rat by elevating the concentration of calcium in the brain.
When the concentration of calcium ions in the cerebral ventricles is elevated, a fully satiated rat eats voraciously. This feeding response is not prevented by prior intraventricular administration of alpha-or beta-adrenergic blocking agents, or other pharmacological antagonists. This supports the concept of an independent ionic mechanism, rather than a neurotransmitter one, for modulating a "set-point" for weight or hunger.
D000818:Animals; D001066:Appetite / Q000187:drug effects; D001923:Brain Chemistry; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D002552:Cerebral Ventricles; D004327:Drinking Behavior / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D007267:Injections; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011433:Propranolol; D002118:Calcium; D009638:Norepinephrine; D010646:Phentolamine