Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide.
Dimethyl sulfoxide added to cultures first treated with 5-iododeoxyuridine increased C-type virus production approximately tenfold in a human rhabdomyosarcoma cell line. 5-Iododeoxyuridine followed by dimethyl sulfoxide also activated a similar C-type virus in a metastatic tumor from a bronchial node taken from a 52-year-old male.
D000230:Adenocarcinoma / Q000382:microbiology*; D002478:Cells, Cultured; D003857:Deoxyuridine / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004721:Endoplasmic Reticulum; D006801:Humans; D007181:Inclusion Bodies, Viral; D007455:Iodine / Q000494:pharmacology*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009858:Oncogenic Viruses / Q000254:growth & development*; D012208:Rhabdomyosarcoma / Q000382:microbiology*
D007455:Iodine; D003857:Deoxyuridine; D004121:Dimethyl Sulfoxide