Synaptogenesis in the rat cerebellum: effects of early hypo- and hyperthyroidism.
The number of synapses in the molecular layer of the rat cerebellum is reduced by early hypo-and hyperthyroidism within 30 days. Hypothyroidism retards synaptogenesis after 10 days, while hyperthyroidism accelerates synaptogenesis initially, but by 21 days the number of synapses is reduced. The sensitivity of developing synapses to thyroid hormone may permit analysis of the events triggering synaptogenesis.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000254:growth & development*; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000503:physiopathology*; D007037:Hypothyroidism / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011441:Propylthiouracil; D051381:Rats; D013569:Synapses; D013963:Thyroid Hormones / Q000502:physiology; D013974:Thyroxine
D013963:Thyroid Hormones; D011441:Propylthiouracil; D013974:Thyroxine