Carboxyhemoglobin elevation after exposure to dichloromethane.
Inhalation of dichloromethane vapor in concentrations of 500 to 1000 parts per million for 1 to 2 hours promptly initiated the formation of significant quantities of carbon monoxide in human subjects. The evidence suggests that carbon monoxide may be a metabolite of dichloromethane and, that exposure to concentrations of dichloromethane below the industrial threshold limit values may result in the formation of carbon monoxide in amounts that exceed the allowable limits.
D000328:Adult; D002248:Carbon Monoxide / Q000096:biosynthesis / Q000097:blood*; D002849:Chromatography, Gas; D004781:Environmental Exposure; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000009:adverse effects* / Q000378:metabolism; D008297:Male; D013057:Spectrum Analysis; D013997:Time Factors; D014558:Urobilinogen / Q000652:urine
D006454:Hemoglobins; D006846:Hydrocarbons, Halogenated; D014558:Urobilinogen; D002248:Carbon Monoxide