Correlation of antihypertensive activity with structure in a series of 2H-1,2,4-benzothiadiazine 1,1-dioxides using the substituent constant approach.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D001581:Benzothiadiazines / Q000494:pharmacology*; D001665:Binding Sites; D066298:In Vitro Techniques; D007700:Kinetics; D008956:Models, Chemical; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D051381:Rats; D011955:Receptors, Drug / Q000187:drug effects; D013223:Statistics as Topic; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000494:pharmacology
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D011955:Receptors, Drug; D013450:Sulfones; D009638:Norepinephrine