Stimulation by phagocytosis of the deiodination of L-thyroxine in human leukocytes.
Intact human leukocytes actively deiodinate L-[(131)1] thyroxine, producing mainly inorganic (131)1 and chromatographically immobile (131)1-labeled origin material. When phagocytosis is induced, the deiodination is enhanced, a suggestion that deiodination in mediated by a peroxidase-hydrogen peroxide system. l-Thyroxine can serve as a source of iodine for iodination reactions within the leukocyte.
D001345:Autoradiography; D002854:Chromatography, Paper; D006801:Humans; D066298:In Vitro Techniques; D007454:Iodides / Q000032:analysis; D007456:Iodine Isotopes; D007962:Leukocytes / Q000378:metabolism*; D010587:Phagocytosis; D014284:Triiodothyronine / Q000378:metabolism*
D007454:Iodides; D007456:Iodine Isotopes; D014284:Triiodothyronine