Effect of D-cycloserine on transformation in group H streptococcus, strain Challis.
d-Cycloserine (d-CS), a selective inhibitor of bacterial cell wall biosynthesis, inhibited transformation in group H streptococcus, strain Challis, by preventing the development of the competent state. The incubation of strain Challis cells with d-CS resulted in the production of a substance which inhibited the action of competence factor on these cells. d-CS had an enhancing effect on transformation when deoxyribonucleic acid uptake or phenotypic expression was allowed to occur in its presence.
D002473:Cell Wall / Q000378:metabolism; D003470:Culture Media; D003523:Cycloserine / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000378:metabolism; D008851:Micropore Filters; D010641:Phenotype / Q000187:drug effects; D012703:Serotyping; D013237:Stereoisomerism; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D013997:Time Factors; D014170:Transformation, Genetic / Q000187:drug effects*
D003470:Culture Media; D004269:DNA, Bacterial; D003523:Cycloserine