Immunogenicity of rabies virus inactivated by  -propiolactone, acetylethyleneimine, and ionizing irradiation.
Ionizing radiation, beta-propiolactone, and acetylethyleneimine were compared for their ability as virus-inactivating agents for the preparation of rabies vaccine. Each agent reduced viral infectivity exponentially; ionizing radiation also destroyed viral hemagglutinin. The vaccine prepared by ionizing radiation was equal or superior to that prepared by beta-propiolactone in its ability to protect mice from rabies infection. The acetylethyleneimine-treated vaccine was a less potent immunogen.
D000085:Acetates / Q000494:pharmacology; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002460:Cell Line / Q000382:microbiology; D003036:Cobalt Isotopes; D003168:Complement Fixation Tests; D006224:Cricetinae; D005030:Ethylenes / Q000494:pharmacology; D006386:Hemagglutination Tests; D006389:Hemagglutinins, Viral / Q000032:analysis; D006571:Heterocyclic Compounds / Q000494:pharmacology; D007097:Imines / Q000494:pharmacology*; D007668:Kidney; D007783:Lactones / Q000494:pharmacology*; D051379:Mice; D011422:Propionates / Q000494:pharmacology; D011818:Rabies / Q000517:prevention & control; D011819:Rabies Vaccines; D011820:Rabies virus / Q000187:drug effects / Q000276:immunology* / Q000472:pathogenicity / Q000528:radiation effects; D011830:Radiation Effects; D014776:Virus Cultivation
D000085:Acetates; D000956:Antigens, Viral; D003036:Cobalt Isotopes; D005030:Ethylenes; D006389:Hemagglutinins, Viral; D006571:Heterocyclic Compounds; D007097:Imines; D007783:Lactones; D011422:Propionates; D011819:Rabies Vaccines