Plasma aldosterone concentration at delivery and during the newborn period.
Aldosterone concentrations in plasma of women on normal sodium intake undergoing cesarean section were 3.7+/-1.4 ng/100 ml (mean+/-1 SD). These values were significantly lower (P < 0.001) than those observed in mothers on normal sodium diet, delivered by the vaginal route (14.9+/-7.0 ng/100 ml). A significant elevation (P < 0.001) of the concentrations was found if the mothers had been on sodium restriction and/or diuretics (44.9+/-24.2 ng/100 ml). In supine position, adult nonpregnant subjects have aldosterone concentrations in plasma of 1.7+/-1.4 ng/100 ml on normal sodium intake and of 16.7+/-8.1 ng/100 ml on low sodium diet.Simultaneous determinations of aldosterone levels in cord blood showed that cord values were significantly higher than those of the corresponding mother (P < 0.01 by paired t test). However, values in cord blood of infants born to mothers on a normal sodium intake were significantly lower (P < 0.005) than those of infants whose mothers had required low sodium diet and/or diuretics during their pregnancy. Aldosterone concentrations in plasma of infants 1-72 hr of age and born to mothers on normal sodium intake were 25.9+/-11.7 ng/100 ml (mean +/-1 SD). These values were significantly lower (P < 0.005) than those of infants born to mothers on restricted sodium intake with or without diuretics (80.3+/-54.4 ng/100 ml). The concentrations at birth were not significantly different from those observed during the first 3 days of life (P > 0.6).
D000293:Adolescent; D000311:Adrenal Glands / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D036861:Delivery, Obstetric; D004032:Diet; D004039:Diet, Sodium-Restricted; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000378:metabolism; D049590:Postpartum Period; D011247:Pregnancy; D011863:Radioimmunoassay; D012083:Renin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014470:Umbilical Cord
D004232:Diuretics; D000450:Aldosterone; D012964:Sodium; D012083:Renin