Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa.
The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine. The supine and erect systolic pressures were significantly higher and the erect pulse rate significantly lower during administration of L-alpha-methyldopahydrazine. The implications of these observations are discussed.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004295:Dihydroxyphenylalanine / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology / Q000627:therapeutic use; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D008750:Methyldopa / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D011674:Pulse / Q000187:drug effects
D006834:Hydrazines; D008750:Methyldopa; D004295:Dihydroxyphenylalanine; D004298:Dopamine