Synthesis and biologic evaluation of 7-hydroxymethotrexate, 7-methylaminopterin, and 7-methylmethotrexate.
D000818:Animals; D005493:Folic Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008727:Methotrexate / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D008744:Methylamines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D011622:Pterins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D005493:Folic Acid Antagonists; D008744:Methylamines; D011622:Pterins; D008727:Methotrexate