Pharmacological properties of amino-oxyacetic acid in the chicken.
1. The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken.2. AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species.3. The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks.4. The convulsant effect was exerted primarily through supraspinal centres.5. Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.
D000085:Acetates / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects; D002645:Chickens; D004569:Electroencephalography; D009132:Muscles / Q000187:drug effects; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013331:Strychnine / Q000494:pharmacology; D014293:Trimethadione / Q000494:pharmacology
D000085:Acetates; D000927:Anticonvulsants; D013331:Strychnine; D014293:Trimethadione