Isolation and characterization of two major urinary metabolites of   1 -tetrahydrocannabinol.
Two of the major metabolites which appear in rabbit urine after the administration of Delta(1)-tetrahydrocannabinol have been isolated and their structures have been tentatively established. The available evidence indicates that they are 7-carboxy-Delta(1)-tetrahydrocannabinols with an additional hydroxyl group on the side chain. The substances occur both free and as conjugates.
D000818:Animals; D002188:Cannabis / Q000378:metabolism* / Q000652:urine*; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000652:urine; D002848:Chromatography, DEAE-Cellulose; D013759:Dronabinol / Q000302:isolation & purification / Q000378:metabolism / Q000652:urine; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008745:Methylation; D011817:Rabbits
D002264:Carboxylic Acids; D013759:Dronabinol