Decreased levels of cytochrome P-450 and catalase in hepatic porphyria caused by substituted acetamides and barbiturates. Importance of the allyl group in the molecule of the active drugs.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000081:Acetamides / Q000494:pharmacology; D000085:Acetates / Q000494:pharmacology*; D000498:Allyl Compounds / Q000494:pharmacology; D000577:Amides / Q000494:pharmacology*; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D002374:Catalase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury; D003580:Cytochromes / Q000378:metabolism*; D005260:Female; D006418:Heme / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism; D011164:Porphyrias / Q000139:chemically induced / Q000378:metabolism*; D011166:Porphyrins / Q000096:biosynthesis; D051381:Rats; D013329:Structure-Activity Relationship
D000081:Acetamides; D000085:Acetates; D000498:Allyl Compounds; D000577:Amides; D001463:Barbiturates; D003580:Cytochromes; D011166:Porphyrins; D006418:Heme; D002374:Catalase; D000624:5-Aminolevulinate Synthetase