Salicylate: action on normal body temperature in rats.
Rats receiving intraperitoneal injections of sodium salicylate (30 to 300 milligrams per kilogram of body weight) showed a decline in rectal temperature of up to 5.5 degrees C when placed in a 5 degrees C environment. High dosages of salicylate lowered the rectal temperatures of rats kept in a 23 degrees C environment. The finding that salicylate can lower nonfebrile body temperature suggests that this class of antipyretic agents does affect normal temperature regulation.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects; D003080:Cold Temperature; D005260:Female; D007274:Injections, Intraperitoneal; D051381:Rats; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology; D013997:Time Factors
D012459:Salicylates; D012964:Sodium