Cardiovascular effects of methylmethacrylate cement.
Experiments were carried out on dogs in an attempt to identify the mechanisms underlying the systemic hypotension associated with the application of acrylic cement substances to raw bone surfaces, as in reconstructive hip surgery. Intravenous injection of the liquid component of such cements (monomeric methylmethacrylate) into six dogs produced a significant fall in blood pressure together with an increase in heart rate and cardiac output. This seemed to be due to peripheral vasodilatation caused directly by the monomer and not through the release of histamine. Absorption of free monomer from the mixed cement into the systemic circulation at operation is likely to have the same effect. Precautionary measures can be taken and groups of patients who are especially at risk can be identified, thus reducing the hazards of total hip replacement.
D000180:Acrylic Resins / Q000633:toxicity*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000633:toxicity; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002496:Central Venous Pressure / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006621:Hip Joint / Q000601:surgery; D007275:Injections, Intravenous; D008102:Liver Circulation / Q000187:drug effects; D008768:Methylmethacrylates / Q000494:pharmacology / Q000633:toxicity; D010477:Perfusion; D014665:Vasodilator Agents / Q000494:pharmacology
D000180:Acrylic Resins; D001843:Bone Cements; D008768:Methylmethacrylates; D014665:Vasodilator Agents