Initiation of protein synthesis at an unusual position in an immunoglobulin gene?
The amino acid sequence of urinary beta(2)-microglobulin has been partially determined and found to be related to the constant region of IgG immunoglobulin heavy chain. beta(2)-Microglobulin is present in normal individuals. Its gene may have evolved from an immunoglobulin gene by the use of an unusually located start signal for initiating synthesis of the polypeptide.
D000595:Amino Acid Sequence; D001536:Bence Jones Protein; D005796:Genes; D005916:Globulins / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007072:Immunoglobulin D / Q000032:analysis; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis*; D009194:Myeloma Proteins / Q000032:analysis; D010442:Peptide Chain Initiation, Translational
D005916:Globulins; D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007136:Immunoglobulins; D009194:Myeloma Proteins; D007073:Immunoglobulin E; D001536:Bence Jones Protein