Isovaleric and -methylbutyric acidemias induced by hypoglycin A: mechanism of Jamaican vomiting sickness.
Hypoglycin A, the causative agent of the Jamaican vomiting sickness, produced a marked increase in concentration of isovaleric acid in the plasma of rats, when administered in a single dose. alpha-Methylbutyric acid, a position isomer, also accumulated. The use of hypoglycin A reproduced some features of human isovaleric acidemia. Accumulation of these branched pentanoic acids may be another factor contributing to the pathogenesis of the Jamaican vomiting sickness.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002087:Butyrates / Q000097:blood*; D003521:Cyclopropanes / Q000494:pharmacology*; D005638:Fruit / Q000032:analysis*; D005977:Glutarates / Q000652:urine; D005998:Glycine / Q000652:urine; D007930:Leucine / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D014631:Valerates / Q000652:urine
D001786:Blood Glucose; D002087:Butyrates; D003521:Cyclopropanes; D005977:Glutarates; D010936:Plant Extracts; D014631:Valerates; D007930:Leucine; D005998:Glycine