Deuterium oxide: inhibition of calcium release in muscle.
Calcium release, measured as luminescence of the protein aequorin, was measured simultaneously with membrane potential and isometric tension in single muscle fibers of the barnacle (Balanus nubilus). Deuterium oxide inhibited calcium release and isometric tension but did not affect membrane potential, a result consistent with the postulate that deuterium oxide inhibits the coupling between excitation and contraction.
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D003903:Deuterium / Q000494:pharmacology*; D066298:In Vitro Techniques; D049449:Luminescence; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000378:metabolism* / Q000502:physiology; D010087:Oxides / Q000494:pharmacology; D011506:Proteins; D001468:Thoracica
D010087:Oxides; D011506:Proteins; D003903:Deuterium; D002118:Calcium