Effects of ultrasonic nebulization on pulmonary mechanics and blood gases in obstructive pulmonary disease.
Administration of ultrasonically nebulized mist to 17 patients with obstructive lung disease resulted in a temporary deterioration of mechanical lung function with decreases in vital capacity (VC), forced expired volume in one second expressed as a percentage of VC (FEV(1)%), and compliance and with increased inspiratory and expiratory airway resistance. Despite hyperventilation there was an associated decrease in arterial oxygen tension. Although concomitant administration of a bronchodilator afforded protection against the bronchospastic reaction, blood gas derangements were still provoked.
D000336:Aerosols; D000402:Airway Obstruction / Q000628:therapy; D000403:Airway Resistance; D001827:Body Height; D001835:Body Weight; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006985:Hyperventilation; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance; D008173:Lung Diseases, Obstructive / Q000503:physiopathology / Q000628:therapy*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D014465:Ultrasonics
D000336:Aerosols; D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D010100:Oxygen