Age changes in the neuronal microenvironment.
The extracellular space of the rat brain was visualized by electron roscopy in sections of cerebral cortex fixed by freeze-substitution. The volume tissue occupied by the extracellular space was estimated stereomnetrically, and found to decrease from 20.8 percent in 3-month-old rats to 9.6 percent in escent animals, 26 months of age. This decrease in extracellular space indicates age-associated change in the microenvironment of nerve cells.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology*; D005110:Extracellular Space / Q000166:cytology*; D005615:Freezing; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000166:cytology*; D051381:Rats; D014021:Tissue Preservation