Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes.
The capacity of lymphoid cells from nonsensitized mice to lyse antibody-coated target erythrocytes in vitro does not require the presence of thymus-derived or thymus-dependent lymphocytes. Thus, spleen cells from thymus-deprived mice and spleen cell populations from which thymus-dependent lymphocytes had been removed were fully competent to mediate destruction of antibody-coated target cells. However, prior treatment of spleen cell populations with antibody to kappa chains diminished this function, suggesting a role for bone marrow-derived lymphocytes.
D000818:Animals; D000906:Antibodies; D000961:Antilymphocyte Serum; D001345:Autoradiography; D002859:Chromium Isotopes; D003165:Complement System Proteins; D003601:Cytotoxicity Tests, Immunologic; D004912:Erythrocytes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D000906:Antibodies; D000961:Antilymphocyte Serum; D002859:Chromium Isotopes; D003165:Complement System Proteins