Trophic regulation of acetylcholine sensitivity of muscle: effect of electrical stimulation.
Denervation of skeletal muscle results in a spread of acetylcholine sensitivity over the entire surface membrane. Electrical stimulation, programmed to mimic the normal activity pattern, was applied continuously to the denervated rat diaphragm in vivo. After 4 days, the acetylcholine sensitivity was far less in the stimulated diaphragms than in denervated controls. Muscle activity may account for "neurotrophic" regulation of the acetylcholine sensitivity.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D003964:Diaphragm / Q000187:drug effects; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005071:Evoked Potentials; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects*; D051381:Rats
D000109:Acetylcholine