Carbonic anhydrase and bone remodeling: sulfonamide inhibition of bone resorption in organ culture.
Five sulfonamide inhibitors of carbonic anhydrase inhibited parathyroid hormone-induced resorption of bone in organ culture. The relative activities of the sulfonamides as resorption inhibitors were such as to suggest the presence of a functional carbonic anhydrase system in bone linked to the mechanism of bone resorption.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000201:enzymology; D002118:Calcium / Q000378:metabolism; D002127:Calcium Isotopes; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D005123:Eye / Q000201:enzymology; D005624:Frontal Bone; D007668:Kidney / Q000201:enzymology; D051379:Mice; D009924:Organ Culture Techniques; D010281:Parathyroid Hormone / Q000494:pharmacology; D010294:Parietal Bone; D013424:Sulfanilamides / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*
D002127:Calcium Isotopes; D002257:Carbonic Anhydrase Inhibitors; D010281:Parathyroid Hormone; D013424:Sulfanilamides; D013449:Sulfonamides; D000086:Acetazolamide; D002118:Calcium