Synergy of ethanol and putative neurotransmitters: glycine and serine.
The putative neurotransmitters, glycine and serine, significantly enhanced the sleeping time (loss of the righting reflex) that was induced by ethanol in mice. The observed synergistic effect between ethanol and the amino acids is probably not related to an alteration of ethanol metabolism, but rather to an interaction of these compounds in the central nervous system.
D000818:Animals; D001923:Brain Chemistry; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D051379:Mice; D012018:Reflex / Q000187:drug effects; D012694:Serine / Q000008:administration & dosage / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*
D000431:Ethanol; D012694:Serine; D005998:Glycine