Lymphoid cells in delayed hypersensitivity. 3. The influence of x-irradiation on passive transfer and on in vitro production of soluble mediators.
X-irradiation up to 480 R does not inhibit either adoptive transfer of delayed hypersensitivity or production in vitro of soluble mediators, such as migration-inhibitory factor (MIF). Above that dosage and as high as 3000 R, adoptive transfer is inhibited, but production of MIF is not. An increase in skin response occurred when 24-48 hr were allowed to elapse after intravenous transfer and before skin testing. Treatment of recipients with colchicine at the time of adoptive transfer inhibited the development of a skin reaction to specific antigen.
D000818:Animals; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D011828:Radiation Chimera; D012882:Skin Tests; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors
D003078:Colchicine