Diphtheria-tetanus-pertussis immunization by intradermal jet injection.
An intradermal jet injector was used to administer combined diphtheria, tetanus, and pertussis (D.T.P.) vaccines to infants aged 2 to 12 months. A second dose was given one month after the first and a third six months after the second. Each dose was considerably smaller than the standard intramuscular dose. Blood samples taken one month after the third dose showed a satisfactory diphtheria and tetanus antitoxin response in all but a few cases. The antibody response to the pertussis component was not examined. Reactions were insignificant. Intradermal jet injection is proposed as a cheap, extremely rapid, and effective technique for D.T.P. immunization, especially suitable for use in remote areas where trained staff and facilities are few and many children require immunization.
D000917:Antibody Formation; D004165:Diphtheria / Q000517:prevention & control*; D004166:Diphtheria Antitoxin / Q000032:analysis; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007223:Infant; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D007277:Injections, Jet; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage*; D013742:Tetanus / Q000517:prevention & control*; D013743:Tetanus Antitoxin / Q000032:analysis; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D014917:Whooping Cough / Q000517:prevention & control*
D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D013743:Tetanus Antitoxin; D013745:Tetanus Toxoid