Neuromuscular transmission: inhibition by manganese ions.
Manzganiese ions. are potent blocking argenits of synaptic transmission at the neuromuscular junction in the frog. The main site of action is the presynaptic nerve terminal, where the ions decr-ease the amount of transmitter liberated by a never impulse. The inihibition produced by manganese is reversible.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001001:Anura; D002118:Calcium / Q000494:pharmacology; D066298:In Vitro Techniques; D008345:Manganese / Q000494:pharmacology*; D009046:Motor Neurons / Q000187:drug effects; D009467:Neuromuscular Depolarizing Agents; D009469:Neuromuscular Junction / Q000187:drug effects
D009467:Neuromuscular Depolarizing Agents; D008345:Manganese; D002118:Calcium