Lead and methyl mercury: effects of acute exposure on cytochrome P-450 and the mixed function oxidase system in the liver.
The rat liver mixed function oxidase system which is responsible for the metabolism of endogenous and exogenous compounds has been shown to be affected by lead and methyl mercury. Administration of these environmental pollutants to rats results in a decrease in cytochrome P-450 content and inhibition of in vitro N-demethylase and hydroxylase activities. The in vitro enzyme-inhibiting effects of the metals found pharmacological expression in the whole animal by prolongation of hexobarbital-induced sleeping times.
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003580:Cytochromes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003864:Depression, Chemical; D004781:Environmental Exposure; D004787:Environmental Pollution; D006591:Hexobarbital / Q000494:pharmacology; D007855:Lead Poisoning / Q000201:enzymology*; D008297:Male; D008630:Mercury Poisoning / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009019:Morphinans / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism; D051381:Rats; D012890:Sleep; D013439:Sulfhydryl Reagents / Q000494:pharmacology; D013997:Time Factors
D000814:Aniline Compounds; D003580:Cytochromes; D009019:Morphinans; D010860:Pigments, Biological; D013439:Sulfhydryl Reagents; D006591:Hexobarbital; D006899:Mixed Function Oxygenases