Salicylate: a structure-activity study of its effects on membrane permeability.
Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008974:Mollusca; D009474:Neurons / Q000502:physiology*; D012459:Salicylates / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D001565:Benzoates; D012459:Salicylates