Berberine in toxin-induced experimental cholera.
1. Oral administration of berberine to infant rabbits 18-24 h before the intraintestinal administration of choleragenic toxins, arrests diarrhoea or significantly prolongs the survival time.2. The use of berberine in the treatment of clinical cholera is further justified.3. Berberine is an antidiarrhoeal drug and the host tissues play a major part in the control of diarrhoeal symptoms.
D000818:Animals; D001600:Berberine Alkaloids / Q000627:therapeutic use*; D002771:Cholera / Q000139:chemically induced / Q000188:drug therapy*; D003967:Diarrhea / Q000517:prevention & control; D004195:Disease Models, Animal; D011817:Rabbits; D014118:Toxins, Biological; D014733:Vibrio
D001600:Berberine Alkaloids; D014118:Toxins, Biological