Delta 9-tetrahydrocannabinol: aversive effects in rat at high doses.
Water-deprived rats were administered a single dose of Delta(9)-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.
D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal / Q000187:drug effects*; D002188:Cannabis / Q000494:pharmacology*; D013759:Dronabinol / Q000008:administration & dosage / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D008297:Male; D010919:Placebos; D051381:Rats; D012439:Saccharin; D014868:Water Deprivation
D010919:Placebos; D013759:Dronabinol; D012439:Saccharin