Urinary tract infection and oral penicillin G.
The urinary excretion of three oral preparations of penicillin G was measured in six subjects. After a dose of 500 mg of potassium penicillin G the mean urine level was 597 mug/ml in the first of three two-hour periods, 324 mug/ml in the second, and 40 mug/ml between the fourth and sixth hours. Of the dose, 13.4% was excreted in the urine in 24 hours. Differences among the three preparations were not significant therapeutically. Most Gram-negative urinary pathogens are sensitive to 5-50 mug of penicillin G per ml. There is a rational basis for the use of oral penicillini G to treat urinary infection due to Gram-negative bacilli.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D005069:Evaluation Studies as Topic; D006801:Humans; D010400:Penicillin G / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D013997:Time Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
D010400:Penicillin G