Haem biosynthesis studied in patients with rheumatoid arthritis.
In a study of the urinary excretion of haem precursors in patients with rheumatoid arthritis, iron-deficiency anaemia, and in healthy controls, certain differences were found. In iron-deficiency anaemia the excretion of both porphobilinogen and delta-aminolevulinic acid was increased, whereas in patients with rheumatoid arthritis only the porphobilinogen excretion was increased.A further study on the erythrocyte activity of delta-aminolevulinic acid dehydrase showed a higher activity in the erythrocytes from patients with rheumatoid arthritis compared with healthy controls.
D000747:Anemia, Hypochromic / Q000378:metabolism / Q000652:urine; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000652:urine; D004912:Erythrocytes / Q000201:enzymology; D006418:Heme / Q000096:biosynthesis* / Q000652:urine; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood; D007982:Levulinic Acids / Q000652:urine; D011166:Porphyrins / Q000652:urine; D011758:Pyrroles / Q000652:urine
D007982:Levulinic Acids; D011166:Porphyrins; D011758:Pyrroles; D006418:Heme; D006836:Hydro-Lyases