Inhibition of prostaglandin biosynthesis by corticosteroids.
Since prostaglandins have been consistently recovered from a wide range of inflammatory reactions, including cutaneous inflammation, we have studied the effect of the anti-inflammatory corticosteroids hydrocortisone and fluocinolone on in-vitro biosynthesis of prostaglandins by skin. Skin homogenates synthesized prostaglandins E(2) and F(2)alpha in the presence of an excess of arachidonic acid substrate. Inhibition of biosynthesis of both these prostaglandins by corticosteroids was demonstrated. Since several members of the prostaglandin group of agents can reproduce all the cardinal features of inflammation and are found in a wide range of inflammatory reactions it is concluded that at least part of the anti-inflammatory properties of corticosteroids is due to inhibition of prostaglandin biosynthesis.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005260:Female; D005446:Fluocinolone Acetonide / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D005446:Fluocinolone Acetonide; D006854:Hydrocortisone