Genetic control of lactate dehydrogenase expression in mammalian tissues.
The amount of lactate dehydrogenase isozyme 4 in erythrocytes of mice is controlled by alleles at the Ldr-1 locus. The A subunits of lactate dehydrogenase from erythrocytes deficient in isozyme 4 cannot assemble in vitro with B subunits to form active isozyme. The inability to form hybrid enzyme is not due to a mutation in the structural gene for the A polypeptide. Rather, a factor that is bound to the A subunits of erythrocytes restricts free exchange with B subunits.
D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D004592:Electrophoresis, Starch Gel; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005796:Genes; D007527:Isoenzymes; D007668:Kidney / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000201:enzymology; D011489:Protein Denaturation
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase