The influence of drugs upon the anticoagulant activity of heparin.
Although physical incompatibility between heparin and a number of drugs has been reported we did not discover any evidence of such incompatibility when heparin was mixed with 11 commonly used drugs in therapeutic concentrations.Furthermore, there was no detectable change in the anticoagulant activity in the presence of any of these drugs, nor was there any change in the biological activity of the antibiotics tested.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002512:Cephalothin / Q000494:pharmacology; D003023:Cloxacillin / Q000494:pharmacology; D004347:Drug Interactions; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014803:Vitamin B Complex / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013386:Succinates; D014803:Vitamin B Complex; D011189:Potassium Chloride; D000667:Ampicillin; D006493:Heparin; D008012:Lidocaine; D013752:Tetracycline; D007545:Isoproterenol; D003023:Cloxacillin; D001205:Ascorbic Acid; D010400:Penicillin G; D002512:Cephalothin; D006854:Hydrocortisone