Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.
D000577:Amides / Q000378:metabolism; D000818:Animals; D002247:Carbon Isotopes; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002854:Chromatography, Paper; D002999:Clone Cells / Q000187:drug effects; D003520:Cyclophosphamide / Q000378:metabolism*; D003580:Cytochromes / Q000494:pharmacology; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009538:Nicotine / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010756:Phosphoric Acids / Q000378:metabolism; D011241:Prednisone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
D000577:Amides; D002247:Carbon Isotopes; D003580:Cytochromes; D010756:Phosphoric Acids; D000431:Ethanol; D013739:Testosterone; D009538:Nicotine; D003520:Cyclophosphamide; D010088:Oxidoreductases; D011241:Prednisone; D006854:Hydrocortisone; D010634:Phenobarbital