title: Viral and cellular surface antigens of murine leukemias and myelomas. Serological analysis by immunoelectron microscopy.
abstract: IMMUNOELECTRON MICROSCOPY (IEM) OF MOUSE CELLS WHICH WERE PRODUCTIVELY INFECTED WITH MURINE LEUKEMIA VIRUS (MULV) YIELDED THE FOLLOWING CONCLUSIONS: See PDF for Structure With two exceptions, the alloantigens H-2, theta, Ly-A, and Ly-B were not present on complete or incomplete virions produced by cells bearing these antigens.The exceptions were H-2(k) (but not H-2(b)) and theta both appeared on only a minority of virions and never on more than a small part of the circumference. The incidental discovery of an additional envelope antigen on virions produced by a BALB/c mouse myeloma but lacking from passage A Gross virions distinguishes these two viruses as MuLV subtypes; it also illustrates that IEM can be applied as a primary tool for antigenic analysis, as well as for its usual purpose of finding out where antigens are situated.
mesh_terms: D000406:AKR murine leukemia virus / Q000276:immunology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D000961:Antilymphocyte Serum; D002462:Cell Membrane / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D007111:Immunity, Cellular; D007519:Isoantigens / Q000032:analysis*; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000276:immunology*; D009368:Neoplasm Transplantation; D010942:Plant Viruses / Q000276:immunology; D013154:Spleen / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D000961:Antilymphocyte Serum; D007519:Isoantigens