A metabolic interaction in vivo between cannabidiol and   1 -tetrahydrocannabinol.
The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Delta(1)-tetrahydrocannabinol ((3)H-Delta(1)-THC; 1.0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Delta(1)-THC and its centrally active metabolite 7-hydroxy-Delta(1)-THC: the changes produced were respectively 1.4 and 2.0 fold.Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Delta(1)-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.
D000818:Animals; D001681:Biological Assay; D001921:Brain / Q000378:metabolism*; D002188:Cannabis / Q000378:metabolism*; D002845:Chromatography; D013759:Dronabinol / Q000378:metabolism; D008297:Male; D051381:Rats; D014316:Tritium
D014316:Tritium; D013759:Dronabinol