Oxygen affinity in red cells: changes induced in vivo by propranolol.
Propranolol, a blocking agent for the beta adrenergic receptor, produces a redistribution of 2,3-diphosphoglycerate in the red cell. At concentrations of 3.3 x10(-5)M, 2,3-diphosphoglycerate in the red cell membrane becomes unbound in vitro. The administration of propranolol to hunmns produces similar changes and results in a decrease in the affinity of hemoglobin for oxygen.
D002462:Cell Membrane / Q000032:analysis; D004837:Epinephrine / Q000494:pharmacology; D004912:Erythrocytes / Q000032:analysis* / Q000187:drug effects; D005994:Glycerophosphates / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D066298:In Vitro Techniques; D010100:Oxygen / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology*
D005994:Glycerophosphates; D006454:Hemoglobins; D011433:Propranolol; D010100:Oxygen; D004837:Epinephrine