Hyperlactataemia in phenformin-treated diabetics.
Raised fasting blood lactate levels were observed in diabetic patients on phenformin in therapeutic dosage. After an intravenous glucose load this effect was exaggerated and the lactate/pyruvate ratio increased. Withdrawal of the drug led to normal blood lactate levels and a fall in the lactate/pyruvate ratio.
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007773:Lactates / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010629:Phenformin / Q000008:administration & dosage / Q000009:adverse effects*; D011773:Pyruvates / Q000097:blood
D007773:Lactates; D011773:Pyruvates; D010629:Phenformin