title: 11-hydroxy-  9 -tetrahydrocannabinol: pharmacology, disposition, and metabolism of a major metabolite of marihuana in man.
abstract: 11-Hydroxy-Delta(9)-tetrahydrocannabinol, administered intravenously to man, produces psychologic and pharmacologic effects that persist for several hours. The drug and its metabolites are excreted in urine and feces for more than 1 week. The pharmacology, disposition, and metabolism of 11-hydroxy-Delta(9)-tetra-hydrocannabinol mimic that of Delta(9)-tetrahydrocannabinol, thus providing evidence that Delta(9)-tetrahydrocannabinol (the major active component of marihuana) is converted to the 11-hydroxy compound in man, the latter compound being responsible for the effects.
mesh_terms: D000328:Adult; D002188:Cannabis; D013759:Dronabinol / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism / Q000494:pharmacology / Q000652:urine; D005059:Euphoria; D005243:Feces / Q000032:analysis; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D014316:Tritium
chemical_list: D014316:Tritium; D013759:Dronabinol