title: Purification, properties, and synthesis of dihydrofolate reductase from wild type and methotrexate-resistant hamster cells.
mesh_terms: D000818:Animals; D000941:Antigens; D002247:Carbon Isotopes; D002460:Cell Line; D002499:Centrifugation, Density Gradient; D002846:Chromatography, Affinity; D006224:Cricetinae; D004351:Drug Resistance; D004586:Electrophoresis; D005492:Folic Acid / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007106:Immune Sera; D007122:Immunoelectrophoresis; D007668:Kidney / Q000201:enzymology*; D007700:Kinetics; D007930:Leucine / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology*; D008970:Molecular Weight; D011817:Rabbits; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis* / Q000302:isolation & purification; D014316:Tritium; D014461:Ultracentrifugation
chemical_list: D000941:Antigens; D002247:Carbon Isotopes; D007106:Immune Sera; D014316:Tritium; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D007930:Leucine; D008727:Methotrexate