title: Nerve growth factor: stimulation of regenerative growth of central noradrenergic neurons.
abstract: The growth of new axonal sprouts was studied from transected, ascending noradrenergic axons into transplants of iris tissue in the caudal hypothalamus of the rat. A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later. The effect seemed to be proportional to the administered dose of nerve growth factor.
mesh_terms: D000818:Animals; D001369:Axons / Q000032:analysis / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D002552:Cerebral Ventricles; D005260:Female; D005456:Fluorescent Dyes; D006651:Histocytochemistry; D007031:Hypothalamus / Q000601:surgery; D007267:Injections; D007498:Iris / Q000294:innervation / Q000637:transplantation; D008636:Mesencephalon / Q000601:surgery; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats
chemical_list: D005456:Fluorescent Dyes; D009414:Nerve Growth Factors; D009638:Norepinephrine