title: Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal.
abstract: Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.
mesh_terms: D000371:Agglutination; D000937:Antigen-Antibody Reactions; D000941:Antigens; D000942:Antigens, Bacterial; D002448:Cell Adhesion / Q000187:drug effects*; D002610:Cheek / Q000166:cytology; D004847:Epithelial Cells; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification / Q000494:pharmacology; D007136:Immunoglobulins / Q000494:pharmacology*; D010306:Parotid Gland / Q000276:immunology; D013291:Streptococcus / Q000187:drug effects*
chemical_list: D000941:Antigens; D000942:Antigens, Bacterial; D007070:Immunoglobulin A; D007136:Immunoglobulins