title: Paraoxon: effects on rat brain cholinesterase and on growth hormone and prolactin of pituitary.
abstract: Cholinesterase activity of brain and content of growth hormone and prolactin in the pituitary were compared after short-term (3 days) and long-term (14 days) treatment with paraoxon in male and female rats. Within 3 days cholinesterase activity was reduced to between 5 and 15 percent of that in controls. The content of growth hormone in the pituitary was increased in long-term experiments by 50 percent. This increase in paraoxon-treated animals-suggests a possible role of a cholinergic mechanism in the regulation of growth hormone secretion.
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002802:Cholinesterases / Q000032:analysis*; D004589:Electrophoresis, Disc; D005260:Female; D013006:Growth Hormone / Q000032:analysis*; D007274:Injections, Intraperitoneal; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010261:Paraoxon / Q000008:administration & dosage / Q000494:pharmacology; D010902:Pituitary Gland / Q000032:analysis* / Q000187:drug effects; D011388:Prolactin / Q000032:analysis*; D051381:Rats; D012737:Sex Factors; D013997:Time Factors
chemical_list: D009943:Organophosphorus Compounds; D011388:Prolactin; D013006:Growth Hormone; D002802:Cholinesterases; D010261:Paraoxon