Short-latency excitation of brain stem neurones in the rat by acetylcholine.
A fast excitatory response to acetylcholine (ACh) which has not previously been reported, has been found in the rat brain stem. Micro-iontophoretic applications of ACh to single brain stem neurones in unanaesthetized rats excited 81% and inhibited 3% of neurones studied. Two types of excitatory response were distinguished by their time course. Type I ACh excitation of neurones was of long latency resembling that previously reported in various parts of the brain. Type II excitation was of short latency, similar to that of micro-iontophoretically applied glutamate ions and to ACh excitation of Renshaw cells.
D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D007478:Iontophoresis; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D000109:Acetylcholine