Lack of intracellular conversion of dihydrohomofolate to tetrahydrohomofolate in leukemia cells with high levels of dihydrofolate reductase.
D000818:Animals; D002478:Cells, Cultured; D002848:Chromatography, DEAE-Cellulose; D005492:Folic Acid / Q000096:biosynthesis / Q000378:metabolism*; D007939:Leukemia L1210 / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008727:Methotrexate; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D013057:Spectrum Analysis; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014316:Tritium; D014466:Ultraviolet Rays
D014316:Tritium; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate