Supersensitivity to the negative chronotopic action of carbachol and methacholine in the rat.
Pretreatment of rats for 6 days with the ganglion blocking agent, chlorisondamine, produces a 2-3 fold increase in the sensitivity of the heart to the negative chronotropic action of carbachol and methacholine.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002714:Chlorisondamine / Q000494:pharmacology*; D004342:Drug Hypersensitivity / Q000139:chemically induced; D004357:Drug Synergism; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008688:Methacholine Compounds / Q000494:pharmacology*; D051381:Rats
D008688:Methacholine Compounds; D002217:Carbachol; D002714:Chlorisondamine