The effect of drugs on stress-induced changes of myocardial glycogen and blood glucose concentration in rats.
Rats that were subjected to restraint stress for 18 h were found to have reduced myocardial glycogen and blood sugar levels and showed histological changes in heart and adrenals. The effects of alpha-methyl-p-tyrosine, alpha-methyl-dopa, disulfiram and actinomycin D on these stress-induced changes were examined. Of these drugs, only alpha-methyl-p-tyrosine was able to prevent the fall in myocardial glycogen and blood sugar and none of the drugs prevented the histological changes induced by stress.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D001786:Blood Glucose; D003609:Dactinomycin / Q000494:pharmacology; D004221:Disulfiram / Q000494:pharmacology; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D007103:Immobilization; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D008781:Methyltyrosines / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D001786:Blood Glucose; D008781:Methyltyrosines; D003609:Dactinomycin; D008750:Methyldopa; D006003:Glycogen; D004221:Disulfiram