Fertility impairment in mice on a low fluoride intake.
Female mice maintained on a low fluoride diet over two generations showed a progressive decline in litter production. Mice receiving the same diet supplemented with fluoride reproduced normally and at consistent intervals. Addition of fluoride to the intake of females with demonstrated impaired fertility restored their reproductive capacity.
D000818:Animals; D001724:Birth Weight; D003677:Deficiency Diseases / Q000503:physiopathology; D005260:Female; D005298:Fertility; D005459:Fluorides; D051379:Mice; D011247:Pregnancy; D013997:Time Factors
D005459:Fluorides