Antibody-mediated suppression of grafted lymphoma cells. II. Participation of macrophages.
Specific alloantibody admixed with a grafted murine lymphoma is suppressive of the graft in mice of the inbred strain native to the tumor. Suppressive capacity of the host is obviated in mice given 500 R whole body irradiation before tumor inoculation but is restored when normal peritoneal macrophages are admixed with the tumor-antibody inoculum. Other normal cell types admixed with the tumor-antibody inoculum are not effective in restoring suppressive capacity.
D000818:Animals; D000906:Antibodies; D005122:Exudates and Transudates / Q000276:immunology; D006084:Graft Rejection; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental; D010529:Peritoneal Cavity / Q000166:cytology; D011833:Radiation Injuries, Experimental / Q000276:immunology; D014181:Transplantation Immunology
D000906:Antibodies