title: Irreversible enzyme inhibitors. 196. Active-site-directed irreversible inhibitors of dihydrofolate reductase derived from 1-(4-benzyloxy-3-chlorophenyl)-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazine and bearing a terminal phenyl sulfonate group.
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D002279:Carcinoma 256, Walker / Q000188:drug therapy / Q000201:enzymology; D002478:Cells, Cultured / Q000187:drug effects; D005493:Folic Acid Antagonists; D007939:Leukemia L1210 / Q000188:drug therapy / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D051381:Rats; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000588:Amines; D001593:Benzyl Compounds; D005493:Folic Acid Antagonists; D013451:Sulfonic Acids; D014227:Triazines