title: Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat.
abstract: The diurnal variation in cholesterol synthesis exhibited by rat liver has been examined in fed, fasted, and adrenalectomized animals. Fasting for 3 days caused a lowering of the rate of synthesis but did not abolish the diurnal rhythm. Adrenalectomy abolished the diurnal variation, and caused synthesis to remain at a uniformly high level. We suggest that corticosterone may play an essential role in the daily rhythm of cholesterogenesis.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D002247:Carbon Isotopes; D002784:Cholesterol / Q000096:biosynthesis*; D002940:Circadian Rhythm; D003345:Corticosterone / Q000502:physiology; D005215:Fasting; D008099:Liver / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000085:Acetates; D002247:Carbon Isotopes; D002784:Cholesterol; D008798:Mevalonic Acid; D003345:Corticosterone