title: The T6 translocation in the mouse: its use in trisomy mapping, centromere localization, and cytological identification of linkage group 3.
abstract: The occurrence of hairless piebald mice trisomic for the chromosome segments of the T6M chromosome has shown that the LG III loci hr and s are not located on T6M. The T6 breakpoint in LG III is therefore in the position hr-s-T6. T6M must carry the gene Fkl, which is located on the far side of the T6 breakpoint from hr in LG III.-T6 reduces recombination in the hr-s region.-Trisomy for the chromosome segments of the T6M chromosome appears to severely reduce viability.-The gene hr has been shown to lie between the centromere and the T6 breakpoint. The order of loci in LG III is therefore: centromere-hr-s-T6.-Equations are given for the relation between the frequency of adjacent-2 segregation and the frequency of recovery of complementation zygotes for the case in which the translocation heterozygote can form either quadrivalent or univalent-trivalent configurations at meiosis.-Linkage Group III is carried on chromosome 14. LG VI is the other linkage group involved in T6, and is carried on chromosome 15.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006197:Hair / Q000002:abnormalities; D007247:Infertility, Female; D007248:Infertility, Male; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010858:Pigmentation; D011995:Recombination, Genetic; D013737:Testis / Q000166:cytology; D014314:Trisomy