The effects of cytochalasin B on the microfilaments of baby hamster kidney (BHK-21) cells.
Attempts were made to test the motile functions of bundles of microfilaments found in baby hamster kidney (BHK-21) cells, by using cytochalasin B (CB). It was found that individual cells respond differently to the drug. These differential effects are quite obvious in both light and electron microscope preparations. Some cells contain normal bundles of microfilaments even after 24 hr in CB, and other cells form muscle-like configurations which also contain arrays of microfilaments. These varied effects suggest the existence of several types of microfilaments in BHK-21 cells, and make the interpretation of the motile role of microfilaments difficult to evaluate at the present time.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects; D002477:Cells / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects*; D006224:Cricetinae; D003593:Cytoplasm / Q000187:drug effects; D004121:Dimethyl Sulfoxide; D005347:Fibroblasts; D007668:Kidney; D008854:Microscopy, Electron; D008870:Microtubules / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009183:Mycotoxins / Q000494:pharmacology*
D009183:Mycotoxins; D004121:Dimethyl Sulfoxide