Iodine metabolism: preferential renal excretion of iodide derived from triiodothyronine deiodination.
Measurements were made in rats of the relative rates of accumulation in urine or in the thyroid of radioactive iodide derived from simultaneous injections of (131)I-labeled triiodothyronine and (125)I-labeled iodide. The data indicate that deiodination of triiodothyronine by the kidney results in a loss into the urine of iodine which does not enter the general body iodide pool. This renal "iodide leak" should be considered in kinetic models of iodine metabolism.
D000818:Animals; D002845:Chromatography; D004032:Diet; D007274:Injections, Intraperitoneal; D007454:Iodides / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D007455:Iodine / Q000378:metabolism; D007456:Iodine Isotopes; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000032:analysis; D014284:Triiodothyronine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000652:urine
D007454:Iodides; D007456:Iodine Isotopes; D014284:Triiodothyronine; D007455:Iodine