Alterations in cell proliferation in mouse lung following urethane exposure. 3. Effects of chronic exposure on type 2 alveolar epithelial cell.
The effect of chronic urethane exposure on proliferation of Type 2 alveolar epithelium was investigated by autoradiography. Control mice and mice exposed for 10 weeks to urethane in drinking water were injected with (3)H thymidine and killed at intervals for 7 days. Mean grain counts of Type 2 alveolar cells in the 2 groups showed that the cell cycle time of test mice was prolonged when compared with an estimated 22-hour cycle for controls; this was accompanied by a fivefold increase in labeling index in test animals.
D000818:Animals; D001345:Autoradiography; D001835:Body Weight; D002455:Cell Division / Q000187:drug effects*; D004326:Drinking; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008175:Lung Neoplasms / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000187:drug effects / Q000473:pathology; D013936:Thymidine; D013997:Time Factors; D014316:Tritium; D014520:Urethane / Q000633:toxicity*
D014316:Tritium; D014520:Urethane; D013936:Thymidine