Use of cumulative dose-response curves in potency comparisons of sympathomimetic amines on the cat soleus muscle.
The ability of beta-adrenoceptor agonists to reduce the fusion of incomplete tetanic contractions of the soleus muscle of the cat has been used previously as a model to assess the potential tremor producing effect of sympathomimetic bronchodilators. The ability of (-)-isoprenaline, (-)-adrenaline, (+/-)-soterenol and (+/-)-quinterenol to depress incomplete tetanic contractions of the soleus has now been assessed using cumulative administration of the amines. The method quickly produced accurate and reproducible dose-response curves. It is particularly useful for evaluating the potency of long-acting compounds.
D000818:Animals; D002415:Cats; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008722:Methods; D009119:Muscle Contraction / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D013451:Sulfonic Acids / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced
D011804:Quinolines; D013451:Sulfonic Acids; D013566:Sympathomimetics; D011433:Propranolol; D007545:Isoproterenol; D004837:Epinephrine