title: Iodine metabolism: preferential renal excretion of iodide derived from triiodothyronine deiodination.
abstract: Measurements were made in rats of the relative rates of accumulation in urine or in the thyroid of radioactive iodide derived from simultaneous injections of (131)I-labeled triiodothyronine and (125)I-labeled iodide. The data indicate that deiodination of triiodothyronine by the kidney results in a loss into the urine of iodine which does not enter the general body iodide pool. This renal "iodide leak" should be considered in kinetic models of iodine metabolism.
mesh_terms: D000818:Animals; D002845:Chromatography; D004032:Diet; D007274:Injections, Intraperitoneal; D007454:Iodides / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D007455:Iodine / Q000378:metabolism; D007456:Iodine Isotopes; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000032:analysis; D014284:Triiodothyronine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism* / Q000652:urine
chemical_list: D007454:Iodides; D007456:Iodine Isotopes; D014284:Triiodothyronine; D007455:Iodine