title: Acute renal failure and open heart surgery.
abstract: A retrospective study of 428 open heart operations showed the incidence of mild and severe renal failure to be 26% and 4.7% respectively. The mortality rate was 38% in the mild cases and 70% in the severe cases. Only half of the patients whose death was associated with renal failure showed macroscopic or microscopic renal lesions at necropsy. The patients who developed renal impairment had significantly higher mean preoperative blood urea (40 mg/100 ml) than the non-renal-failure cases (33 mg/100 ml). Periods of perfusion over 60 minutes, mean perfusion pressures below 80 mm Hg, and multiple valve replacement operations also increased the incidence of renal failure. There was no statistical correlation between the age of individual patients, the degree of cooling, and postoperative blood urea values. There was no evidence to suggest that frusemide or mannitol separately or together influenced the development of renal failure. Peritoneal dialysis was preferred for initial treatment of patients with severe renal failure, and haemodialysis was required only in special cases.
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001344:Autopsy; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005260:Female; D005665:Furosemide; D006350:Heart Valve Prosthesis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D010477:Perfusion; D010530:Peritoneal Dialysis; D011312:Pressure; D006435:Renal Dialysis; D012189:Retrospective Studies; D013997:Time Factors; D014508:Urea / Q000097:blood
chemical_list: D008353:Mannitol; D005665:Furosemide; D014508:Urea