Fatty liver induction: inverse relationship between hepatic neutral lipid accumulation and dietary polyunsaturated fatty acids in orotic acid-fed rats.
The levels of hepatic neutral lipids in the orotic acid-fed rat were inversely related to the dietary levels of polyunsaturated fatty acids, as in the choline-deficient rat. Hepatic microsomal protein and phospholipid and total hepatic phospholipid were increased in orotic acid-induced fatty livers. The increase in phospholipid was largely restricted to the phosphatidylethanolamines.
D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats; D005228:Fatty Acids, Essential / Q000494:pharmacology*; D005234:Fatty Liver / Q000139:chemically induced* / Q000378:metabolism; D005260:Female; D006591:Hexobarbital / Q000378:metabolism; D008041:Linoleic Acids / Q000494:pharmacology; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009963:Orotic Acid / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010743:Phospholipids / Q000096:biosynthesis; D014176:Protein Biosynthesis; D051381:Rats
D000814:Aniline Compounds; D004041:Dietary Fats; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008055:Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D009963:Orotic Acid; D006591:Hexobarbital