Nicotine blocks the suckling-induced rise in circulating prolactin in lactating rats.
In lactating rats the rapid suckling-induced release of pituitary prolactin into circulating blood is inhibited by a subcutaneous injection of nicotine. This treatment does not block the lesser "stress-induced" rise in prolactin in response to either. Although nicotine may impair milk production by its effect on prolactin release, it does not appear to block milk ejection from the lactating mammary gland.
D000818:Animals; D004987:Ethers / Q000494:pharmacology; D005260:Female; D007774:Lactation / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004987:Ethers; D009538:Nicotine; D011388:Prolactin