Effect of adrenalectomy on the diurnal variation of hepatic cholesterogenesis in the rat.
The diurnal variation in cholesterol synthesis exhibited by rat liver has been examined in fed, fasted, and adrenalectomized animals. Fasting for 3 days caused a lowering of the rate of synthesis but did not abolish the diurnal rhythm. Adrenalectomy abolished the diurnal variation, and caused synthesis to remain at a uniformly high level. We suggest that corticosterone may play an essential role in the daily rhythm of cholesterogenesis.
D000085:Acetates / Q000378:metabolism; D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D002247:Carbon Isotopes; D002784:Cholesterol / Q000096:biosynthesis*; D002940:Circadian Rhythm; D003345:Corticosterone / Q000502:physiology; D005215:Fasting; D008099:Liver / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D002247:Carbon Isotopes; D002784:Cholesterol; D008798:Mevalonic Acid; D003345:Corticosterone