Metastatic spread of human tumour implanted into thymectomized, antithymocyte serum treated hamsters.
The growth and metastatic spread of human tumours in immunosuppressed hamsters is described. A variety of human tumours were transplanted to the flank or the cheek pouch of the hamsters. Immunosuppression was obtained by combined thymectomy and ATS treatment. In the period up to 4 months after implantation, metastases to the lungs were observed with carcinomata of breast, colon, larynx and kidney; also melanoma, rhabdomyosarcoma, fibrosarcoma and teratoma of testis. Fourteen of 20 different tumours implanted metastasized to the lungs. Only 2 tumours, a hypernephroma and a melanoma, became established at the site of implantation; the remainder regressed even though the tumour was proliferating in the lungs.
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002610:Cheek; D003110:Colonic Neoplasms / Q000473:pathology; D006224:Cricetinae; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology; D006801:Humans; D007106:Immune Sera; D007165:Immunosuppression Therapy; D007680:Kidney Neoplasms / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000473:pathology; D009362:Neoplasm Metastasis / Q000276:immunology*; D009365:Neoplasm Regression, Spontaneous; D009368:Neoplasm Transplantation; D012208:Rhabdomyosarcoma / Q000473:pathology; D013724:Teratoma / Q000473:pathology; D013736:Testicular Neoplasms / Q000473:pathology; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology*; D014183:Transplantation, Heterologous
D007106:Immune Sera