Insulin insensitivity of large fat cells.
Large insulin-insensitive adipocytes from adult rats have normal binding capacities and affinities for insulin. Diminished insulin-like responses to spermine and reduced rates of glucose oxidation are also evident in these cells. The results indicate that the defect responsible for this insulin-resistant state exists in a step subsequent to insulin binding, possibly in transmission of the insulin-receptor "signal" since insensitivity occurs under conditions where glucose transport and oxidative processes are not apparently impaired.
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D007333:Insulin Resistance; D007456:Iodine Isotopes; D010084:Oxidation-Reduction; D011955:Receptors, Drug; D013096:Spermine / Q000494:pharmacology
D007328:Insulin; D007456:Iodine Isotopes; D011955:Receptors, Drug; D013096:Spermine; D005947:Glucose