An original approach to the diagnosis of scoline-induced apnoea.
A new technique is described for measuring the rate of scoline hydrolysis by plasma cholinesterase, which may prove useful in the diagnosis of scoline sensitivity. The importance of extensive family screening is emphasized and three cases possessing a silent gene are described.
D001049:Apnea / Q000139:chemically induced / Q000235:genetics*; D002802:Cholinesterases / Q000097:blood*; D003992:Dibucaine / Q000097:blood; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D010375:Pedigree; D013053:Spectrophotometry; D013390:Succinylcholine / Q000009:adverse effects / Q000378:metabolism*
D002802:Cholinesterases; D013390:Succinylcholine; D003992:Dibucaine