title: The chimpanzee as an animal model for investigating alcoholism.
abstract: Young chimpanzees (Pan troglodytes) will accept ethanol in quantities sufficient to produce symptoms of withdrawal when ethanol is subsequently discontinued. Mild to severe symptoms of physical dependence, including grand mal seizures, are observed when ethanol is abruptly withdrawn after 6 to 10 weeks of chronic oral intake. In addition, the rate of disappearance of ethanol in blood increased during periods of chronic ingestion, an indication of developing metabolic tolerance. These results suggest that the young chimpanzee may be a suitable model for experimental studies of alcoholism.
mesh_terms: D000437:Alcoholism / Q000473:pathology; D000818:Animals; D002849:Chromatography, Gas; D004195:Disease Models, Animal; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D008099:Liver / Q000473:pathology; D002679:Pan troglodytes; D012640:Seizures / Q000097:blood; D013375:Substance Withdrawal Syndrome / Q000097:blood
chemical_list: D000431:Ethanol