Inactivation of isoniazid by Canadian Eskimos and Indians.
Phenotyping for isoniazid inactivation in Canadian Eskimos and Indians showed that the former are all fast acetylators, while only 63.4% of the Indians examined belonged to the same group. Further studies are suggested to confirm this initial finding.During the investigation metabolic studies were carried out to devise a reliable urine test for phenotyping of isoniazid inactivators, to replace the fall-off technique which required venipunctures. The simplicity of the new urine test makes it suitable for mass examinations.
D002170:Canada; D006207:Half-Life; D006801:Humans; D007198:Indians, North American; D004930:Inuit; D007538:Isoniazid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007539:Isonicotinic Acids / Q000652:urine; D008722:Methods; D010641:Phenotype; D013997:Time Factors
D007539:Isonicotinic Acids; D007538:Isoniazid