title: Water-soluble derivatives of   1 -tetrahydrocannabinol.
abstract: Delta1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity. This has been achieved by preparing esters bearing a nitrogen moiety with the use of carbodiimide as the condensing agent. The availability of such water-soluble derivatives will allow the evaluation of Delta1-tetrahydrocannabinol in self-administration studies in monkeys for its addiction liability potential in man. This technique of water solubilization is also applicable to other compounds of chemical and biological significance.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002188:Cannabis / Q000138:chemical synthesis*; D003864:Depression, Chemical; D004285:Dogs; D013759:Dronabinol / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D007097:Imines; D007259:Infrared Rays; D007275:Injections, Intravenous; D009682:Magnetic Resonance Spectroscopy; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D012995:Solubility; D013057:Spectrum Analysis
chemical_list: D007097:Imines; D013759:Dronabinol; D000661:Amphetamine; D009638:Norepinephrine; D004837:Epinephrine