title: Tenuazonic acid, a toxic produced by Alternaria alternata.
abstract: Fifty-seven of 87 isolates of Alternaria alternata (Fr) Keissler grown on autoclaved, moist corn-rice substrate and fed to rats were lethal. The major toxin produced was isolated and characterized as tenuazonic acid. Twenty of 23 toxigenic Alternaria isolates examined produced tenuazonic acid. No tenuazonic acid could be detected in either of the field samples of sorghum or blackeyed peas, which were heavily invaded by Alternaria.
mesh_terms: D000085:Acetates / Q000302:isolation & purification*; D000818:Animals; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D002523:Edible Grain; D005260:Female; D005516:Food Microbiology; D007259:Infrared Rays; D007532:Isoleucine / Q000032:analysis; D003904:Mitosporic Fungi / Q000254:growth & development / Q000472:pathogenicity*; D009183:Mycotoxins / Q000032:analysis / Q000302:isolation & purification* / Q000633:toxicity; D012275:Oryza; D010944:Plants; D011760:Pyrrolidinones / Q000302:isolation & purification*; D051381:Rats; D012639:Seeds; D013053:Spectrophotometry; D014466:Ultraviolet Rays; D003313:Zea mays
chemical_list: D000085:Acetates; D009183:Mycotoxins; D011760:Pyrrolidinones; D007532:Isoleucine