title: Dihydrofolate reductase and thymidylate synthetase in strains of Streptococcus faecium resistant to pyrimethamine, chlorguanide triazine, trimethoprim, and amethopterin.
mesh_terms: D002850:Chromatography, Gel; D004352:Drug Resistance, Microbial; D005493:Folic Acid Antagonists; D005827:Genetics, Microbial; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008727:Methotrexate / Q000494:pharmacology*; D008780:Methyltransferases / Q000032:analysis*; D009154:Mutation; D002727:Proguanil / Q000494:pharmacology*; D011739:Pyrimethamine / Q000494:pharmacology*; D013291:Streptococcus / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D013762:Tetrahydrofolate Dehydrogenase / Q000096:biosynthesis / Q000302:isolation & purification; D013942:Thymine Nucleotides; D014227:Triazines / Q000494:pharmacology*; D014295:Trimethoprim / Q000494:pharmacology; D014500:Uracil Nucleotides
chemical_list: D005493:Folic Acid Antagonists; D013942:Thymine Nucleotides; D014227:Triazines; D014500:Uracil Nucleotides; D014295:Trimethoprim; D013762:Tetrahydrofolate Dehydrogenase; D008780:Methyltransferases; D002727:Proguanil; D008727:Methotrexate; D011739:Pyrimethamine