Nerve growth factor: stimulation of regenerative growth of central noradrenergic neurons.
The growth of new axonal sprouts was studied from transected, ascending noradrenergic axons into transplants of iris tissue in the caudal hypothalamus of the rat. A single intraventricular injection of nerve growth factor, given at the time of axonal damage, resulted in an increased formation and growth of new noradrenaline sprouts 7 days later. The effect seemed to be proportional to the administered dose of nerve growth factor.
D000818:Animals; D001369:Axons / Q000032:analysis / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D002552:Cerebral Ventricles; D005260:Female; D005456:Fluorescent Dyes; D006651:Histocytochemistry; D007031:Hypothalamus / Q000601:surgery; D007267:Injections; D007498:Iris / Q000294:innervation / Q000637:transplantation; D008636:Mesencephalon / Q000601:surgery; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats
D005456:Fluorescent Dyes; D009414:Nerve Growth Factors; D009638:Norepinephrine