Genetic determination of phenotypic variation in sickle cell trait.
Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.
D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000235:genetics*; D002648:Child; D005260:Female; D014644:Genetic Variation; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D044469:Racial Groups
D006455:Hemoglobins, Abnormal