title: On the theory of ion transport across the nerve membrane. V. Two models for the Cole-Moore K +  hyperpolarization delay.
abstract: Two illustrative molecular models, designed to explain the Cole-Moore K(+) hyperpolarization delay, are proposed and analyzed. Both introduce a process supplementary to the usual Hodgkin-Huxley (HH) one for a K(+) channel. In both cases the new process becomes involved as a consequence of the conditioning hyperpolarization of the membrane and would account for the observed delay time in the K(+) current after depolarization to near ENa. The first model uses adsorption or desorption of phospholipid molecules on the surface of the assumed protein K(+) channel or gate. The second model involves the translocation of the charged subunits of the channel in the hyperpolarizing electric field.
mesh_terms: D001692:Biological Transport; D008564:Membrane Potentials; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D010743:Phospholipids / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D011336:Probability; D013997:Time Factors
chemical_list: D010743:Phospholipids; D011188:Potassium