title: Release of 5-hydroxytryptamine from caudate nucleus and septum.
abstract: 1. The anterior horn of one lateral ventricle was perfused in anaesthetized cats treated with inhibitors of monoamine oxidase, and the effluent was tested for 5-hydroxytryptamine (5-HT).2. The basal release of 5-HT varied from 0.25 to 4 ng in 25 min, and was usually about 1 ng.3. The basal release rose and fell with body temperature.4. Electrical stimulation for 15 min of the nucleus linearis intermedius or of the nucleus linearis rostralis caused a release of 5-HT which rarely outlasted the collection period of 25 min.5. Low frequencies (0.5/sec) were, per stimulus, more effective than high frequencies in releasing 5-HT. Over a 15 min period of stimulation, however, the highest total yield was at 20/sec; it fell abruptly at still greater frequencies.6. No release was obtained if the stimulating electrode was positioned in a variety of brain structures outside the two linear nuclei.7. The experiments indicate that 5-HT acts as a transmitter of impulses in neurones originating in the linear nuclei and terminating in caudate nucleus and septum.
mesh_terms: D000818:Animals; D001831:Body Temperature; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000378:metabolism*; D004558:Electric Stimulation; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D008996:Monoamine Oxidase Inhibitors; D009526:Nialamide / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D010477:Perfusion; D011149:Pons / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors; D014191:Tranylcypromine / Q000494:pharmacology
chemical_list: D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D014191:Tranylcypromine; D010293:Pargyline; D009526:Nialamide