Morphine hyperthermia in the rat: its attenuation by physostigmine.
1. In rats, a subcutaneous injection of morphine (2.5 mg/kg) produced hyperthermia which was greatly attenuated by an intraperitoneal injection of physostigmine (0.1 mg/kg), but not of neostigmine (0.08 mg/kg) and promptly reversed by a subcutaneous injection of nalorphine.2. It is concluded that the hyperthermia is a specific response to morphine, central in origin, and the result of diminished acetylcholine (ACh) release from central cholinergic neurones.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000378:metabolism; D005260:Female; D005334:Fever / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D009020:Morphine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D009269:Nalorphine / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism; D010830:Physostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D009388:Neostigmine; D009020:Morphine; D010830:Physostigmine; D000109:Acetylcholine; D009269:Nalorphine