Cell-to-cell interaction in the immune response. 8. Radiosensitivity of thymus-derived lymphocytes.
The helper function of carrier-primed T cells was found to be radiosensitive in vivo. The results could not be attributed to interference with the spleen-seeking properties of the irradiated cells. It is suggested that T cell division is essential for the induction of 7S antibody responses in vivo.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells; D002859:Chromium Isotopes; D006824:Hybridization, Genetic; D007111:Immunity, Cellular; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology* / Q000528:radiation effects*; D051379:Mice; D008815:Mice, Inbred Strains; D011830:Radiation Effects; D011833:Radiation Injuries, Experimental / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014316:Tritium
D002859:Chromium Isotopes; D007074:Immunoglobulin G; D014316:Tritium; D013936:Thymidine