Excretion of  14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus.
1. The metabolism and biliary excretion of (14)C-edrophonium chloride was studied in Wistar rat.2. Approximately 5% of the dose was recovered from bile in 6 hours. Most of the radioactivity was eliminated as (14)C-edrophonium glucuronide. Small amounts of the unchanged drug were also detected in bile, particularly during the first hour after administration of the drug.3. The concentration of (14)C-edrophonium glucuronide in bile was approximately 15-20 times its concentration in plasma.4. In contrast, the concentration of unchanged (14)C-edrophonium was similar in bile and plasma.5. Evidence is presented that unchanged (14)C-edrophonium is transferred from plasma to bile via the peribiliary vascular plexus.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001652:Bile Ducts / Q000098:blood supply*; D002247:Carbon Isotopes; D002855:Chromatography, Thin Layer; D004491:Edrophonium / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005965:Glucuronates / Q000097:blood / Q000378:metabolism; D006499:Hepatic Artery; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008099:Liver / Q000166:cytology*; D008297:Male; D011169:Portal Vein; D051381:Rats; D013997:Time Factors
D002247:Carbon Isotopes; D005965:Glucuronates; D004491:Edrophonium