title: The muscle relaxant activity of methaqualone and its methyl congener.
abstract: Studies with methaqualone and dimethylquinazolone showed them to possess both central and peripheral muscle relaxant activity, the latter only at high dose levels. They selectively inhibited polysynaptic reflexes and were more potent than mephenesin.
mesh_terms: D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D007659:Ketones / Q000494:pharmacology; D008615:Mephenesin / Q000494:pharmacology; D008702:Methaqualone / Q000494:pharmacology*; D051379:Mice; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D011817:Rabbits; D012018:Reflex / Q000187:drug effects
chemical_list: D007659:Ketones; D009125:Muscle Relaxants, Central; D009467:Neuromuscular Depolarizing Agents; D011799:Quinazolines; D008615:Mephenesin; D008702:Methaqualone