Withdrawal depression in obese patients after fenfluramine treatment.
Measurements of subjective feeling in 20 patients receiving fenfluramine alternating with placebo and in 19 patients receiving phentermine alternating with placebo indicated that depression of mood occurred four days after fenfluramine withdrawal but no such depression was seen with phentermine.
D000328:Adult; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000009:adverse effects; D003863:Depression / Q000139:chemically induced*; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D010627:Phenethylamines / Q000009:adverse effects; D010645:Phentermine / Q000009:adverse effects; D010919:Placebos; D013375:Substance Withdrawal Syndrome; D013997:Time Factors
D001067:Appetite Depressants; D010627:Phenethylamines; D010919:Placebos; D005277:Fenfluramine; D010645:Phentermine