Curative potencies against  -amanitin poisoning by cytochrome c.
The fatalities occurring after ingestion of the poisonous mushroom Amanita phalloides are thought to be due to alpha-amanitin. Cytochrome c provided antidotal effects against a lethal dose of this toxin in mice. Significant survival was obtained even when the treatment was withheld for 8 hours. The enzyme was superior to a previously explored therapeutic regimen consisting of penicillin and its combination with chloramphenicol and sulfamethoxazole.
D000818:Animals; D000931:Antidotes; D002701:Chloramphenicol / Q000627:therapeutic use; D003580:Cytochromes / Q000627:therapeutic use*; D005260:Female; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy; D009183:Mycotoxins / Q000506:poisoning*; D010400:Penicillin G / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy; D013420:Sulfamethoxazole / Q000627:therapeutic use; D013997:Time Factors
D000931:Antidotes; D003580:Cytochromes; D009183:Mycotoxins; D002701:Chloramphenicol; D013420:Sulfamethoxazole; D010400:Penicillin G