title: Genetic determination of phenotypic variation in sickle cell trait.
abstract: Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.
mesh_terms: D000328:Adult; D000483:Alleles; D000755:Anemia, Sickle Cell / Q000235:genetics*; D002648:Child; D005260:Female; D014644:Genetic Variation; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D008297:Male; D010641:Phenotype; D044469:Racial Groups
chemical_list: D006455:Hemoglobins, Abnormal