Oligothymidylates: formation by thermal condensation of O 2 ,5'-cyclothymidine 3'-phosphate.
Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.
D055598:Chemical Phenomena; D002621:Chemistry; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D002854:Chromatography, Paper; D003500:Cyclization; D004590:Electrophoresis, Paper; D000431:Ethanol; D006358:Hot Temperature; D009570:Nitriles; D009943:Organophosphorus Compounds; D010756:Phosphoric Acids; D011119:Polynucleotides / Q000138:chemical synthesis*; D013936:Thymidine; D013942:Thymine Nucleotides / Q000138:chemical synthesis; D014105:Tosyl Compounds
D009570:Nitriles; D009943:Organophosphorus Compounds; D010756:Phosphoric Acids; D011119:Polynucleotides; D013942:Thymine Nucleotides; D014105:Tosyl Compounds; D000431:Ethanol; D013936:Thymidine