Type C RNA tumor viruses as determinants of chemical carcinogenesis: effects of sequence of treatment.
Fischer rat embryo cells were treated with 3-methylcholanthrene before or after inoculation with Rauscher murine leukemia virus. Transformation was not observed in untreated control cultures, cultures given virus or 3-methyl-cholanthrene alone, or cultures treated first with 3-methylcholanthrene followed by inoculation with the virus after removal of the chemical. Transformation was dependent upon the presence of Rauscher murine leukemia virus at the time of chemical treatment.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D008748:Methylcholanthrene / Q000494:pharmacology*; D051381:Rats; D011925:Rauscher Virus; D013997:Time Factors
D008748:Methylcholanthrene