title: A scientific rationale for choosing patients rather than normal subjects for Phase I studies.
mesh_terms: D001702:Biopharmaceutics; D064420:Drug-Related Side Effects and Adverse Reactions; D004992:Ethics, Medical; D005069:Evaluation Studies as Topic; D006207:Half-Life; D006805:Human Experimentation; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010600:Pharmacology; D013810:Therapeutic Equivalency
chemical_list: D004364:Pharmaceutical Preparations