The effect of histamine on the electrical activity of rat uterus.
Histamine produces a reduction in the spike frequency and the degree of depolarization which accompany spontaneous and induced contractions of rat uterus. Concentrations of 0.5 mug/ml can cause complete inhibition of both mechanical and electrical activity without producing any change in the resting membrane potential. Concentrations as high as 100 mug/ml cause no appreciable change in membrane potential.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D010121:Oxytocin / Q000037:antagonists & inhibitors; D051381:Rats; D014599:Uterus / Q000187:drug effects*
D010121:Oxytocin; D006632:Histamine; D000109:Acetylcholine