Facilitation of recovery by  -methyl-p-tyrosine after lateral hypothalamic damage.
Rats with bilateral lateral hypothalamic lesions die of starvation in approximately 7 days after surgery. Rats that were treated with alpha-methyl-p-tyrosine for 3 days prior to lateral hypothalamic surgery spontaneously eat, drink, and gain weight after surgery. These data suggest that recovery of function after lateral hypothalamic damage involves denervation supersensitivity.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D003714:Denervation; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology*; D008781:Methyltyrosines / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D011229:Preanesthetic Medication; D051381:Rats
D008781:Methyltyrosines; D009638:Norepinephrine