Galactose utilization in galactosemia.
Cultures of human galactosemic fibroblasts without detectable transferase activity were able to convert [1-(14)C]galactose to (14)CO(2) to the same extent as normal cells, but did so at a significantly slower rate. The utilization of galactose in both normal and galactosemic cells was strongly inhibited by glucose at physiologic concentrations.
D002245:Carbon Dioxide; D002247:Carbon Isotopes; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D005690:Galactose / Q000378:metabolism*; D005693:Galactosemias / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans
D002247:Carbon Isotopes; D002245:Carbon Dioxide; D005947:Glucose; D005690:Galactose