Effects of McN-A-343 and DMPP on the uptake and release of  3 H-noradrenaline by guinea-pig atria.
1. McN-A-343 4-(m-chlorophenylcarbamoyloxy)-2-butynyltrimethylammonium chloride and DMPP (N,N-dimethyl-N'-phenylpiperazinium iodide) inhibit the uptake of (+/-)-(3)H-noradrenaline by guinea-pig atria, being approximately as potent as cocaine in this respect.2. The inhibition of uptake produced by McN-A-343 or DMPP was not affected by atropine or hexamethonium in concentrations which antagonized actions on muscarinic and nicotinic receptors respectively.3. McN-A-343 in the presence of atropine had a positive inotropic action on atria, but this was not accompanied by efflux of radioactivity from atria previously incubated with (-)-(3)H-noradrenaline.4. In the presence of McN-A-343, responses of atria to noradrenaline were increased and those to tyramine were decreased.5. DMPP had positive inotropic and chronotropic actions on atria, and these effects were accompanied by an increase in efflux of radioactivity from atria previously incubated with (-)-(3)H-noradrenaline.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002219:Carbamates / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D013997:Time Factors; D014316:Tritium; D014439:Tyramine / Q000378:metabolism
D002219:Carbamates; D005731:Ganglionic Stimulants; D006584:Hexamethonium Compounds; D010879:Piperazines; D000644:Quaternary Ammonium Compounds; D014316:Tritium; D004246:Dimethylphenylpiperazinium Iodide; D001285:Atropine; D003042:Cocaine; D009638:Norepinephrine; D014439:Tyramine