Disseminated intravascular coagulation induced with leukocyte procoagulant.
The procoagulant activity of rabbit peritoneal leukocytes significantly increased when the leukocytes were incubated in suspension cultures at 37 C for 24 hours. Intravenous infusions of Iysates of 232 x 10(6) rabbit leukocytes which had been incubated in cultures at 37 C for 24 hours produced disseminated intravascular coagulation and vasculitis involving the pulmonary arteries in normal rabbits. Intraaortic infusions of lysates of 230 x 10(6) similarly incubated leukocytes produced renal thrombosis and renal cortical necrosis in normal rabbits. These observations suggest that the procoagulant of granulocytic leukocytes could play a role in the generalized Shwartzman reaction and other syndromes of disseminated intravascular coagulation.
D000818:Animals; D001779:Blood Coagulation Factors / Q000008:administration & dosage / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced* / Q000473:pathology; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007673:Kidney Cortex Necrosis / Q000139:chemically induced / Q000473:pathology; D007962:Leukocytes / Q000378:metabolism*; D011651:Pulmonary Artery / Q000473:pathology; D011817:Rabbits; D012077:Renal Artery / Q000473:pathology; D012790:Shwartzman Phenomenon / Q000209:etiology
D001779:Blood Coagulation Factors