title: Intranuclear distribution of the inducing metal in primary rhabdomyosarcomata induced in the rat by nickel, cobalt and cadmium.
abstract: In primary rhabdomyosarcomata, induced in the rat by intramuscular implantation of powdered metallic nickel, cobalt and cadmium, at least 50% of the high content of inducing metal that accumulates in the nuclei of each tumour, is bound by the nucleoli. The remainder is distributed approximately equally between the nuclear sap and chromatin.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000032:analysis*; D002458:Cell Fractionation; D002466:Cell Nucleolus / Q000032:analysis; D002467:Cell Nucleus / Q000032:analysis*; D002843:Chromatin / Q000032:analysis; D003035:Cobalt / Q000032:analysis*; D004273:DNA, Neoplasm / Q000378:metabolism; D007273:Injections, Intramuscular; D009532:Nickel / Q000032:analysis*; D012334:RNA, Neoplasm / Q000378:metabolism; D051381:Rats; D012208:Rhabdomyosarcoma / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D002843:Chromatin; D004273:DNA, Neoplasm; D012334:RNA, Neoplasm; D002104:Cadmium; D003035:Cobalt; D009532:Nickel