title: Screening for malignant hyperpyrexia.
abstract: The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium.
mesh_terms: D000138:Acidosis; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D008403:Mass Screening; D008722:Methods; D008854:Microscopy, Electron; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000473:pathology; D013390:Succinylcholine / Q000494:pharmacology
chemical_list: D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase; D013390:Succinylcholine; D006221:Halothane