Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 2. Difneozine, a potent, orally active and safe antidiarrheal agent in rats.
D000284:Administration, Oral; D000818:Animals; D002368:Castor Oil; D003061:Codeine / Q000627:therapeutic use; D003486:Cyanides / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D003967:Diarrhea / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D007540:Isonipecotic Acids / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D007928:Lethal Dose 50; D051381:Rats; D011919:Rats, Inbred Strains
D003486:Cyanides; D005765:Gastrointestinal Agents; D007540:Isonipecotic Acids; D002368:Castor Oil; D003061:Codeine