The return of antimetabolite sensitivity in methotrexate- and 6-mercaptopurine-resistant L1210 murine leukemia by the process of adaptive selection.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003433:Crosses, Genetic; D004351:Drug Resistance; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D014644:Genetic Variation; D007042:Hypoxanthines / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D015122:Mercaptopurine / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010430:Pentosyltransferases / Q000378:metabolism; D012641:Selection, Genetic; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D014184:Transplantation, Homologous
D007042:Hypoxanthines; D005492:Folic Acid; D015122:Mercaptopurine; D013762:Tetrahydrofolate Dehydrogenase; D010430:Pentosyltransferases; D008727:Methotrexate