title: Biochemical response of late rickets and osteomalacia to a chupatty-free diet.
abstract: Eight Pakistani children with late rickets and two Pakistani women with osteomalacia were given a chupatty-free diet for seven weeks, substituting leavened bread of lower extraction. On this diet serum calcium levels rose to normal or near normal, levels of serum inorganic phosphorus rose slightly but significantly, and serum alkaline phosphatase levels showed a definite rise indicative of healing bone disease. It is concluded that the high phytate content of unleavened bread is the major cause of late rickets and osteomalacia in Pakistani and Indian communities in the United Kingdom. The simplest prophylactic measure seems to be the additional fortification with calcium carbonate of the high extraction flour used in preparing unleavened bread.
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001939:Bread; D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate / Q000627:therapeutic use; D002136:Calcium, Dietary; D002648:Child; D004035:Diet Therapy; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007194:India; D007294:Inositol / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000139:chemically induced / Q000628:therapy*; D010154:Pakistan; D010758:Phosphorus / Q000097:blood; D012279:Rickets / Q000139:chemically induced / Q000628:therapy*; D006113:United Kingdom
chemical_list: D002136:Calcium, Dietary; D010758:Phosphorus; D007294:Inositol; D000469:Alkaline Phosphatase; D002119:Calcium Carbonate; D002118:Calcium