Bacteriological and pathological study of animals given Freund adjuvant.
Freund complete adjuvant, with allegedly "killed and dried" Mycobacterium butyricum added (intramuscularly in rabbits and intraperitoneally in mice), produced a local granulomatous lesion and frequently a similar lesion in the viscera. Acid-fast bacilli were present in these lesions, and in some animals M. butyricum was obtained in culture. When this culture was inoculated in mice, a similar lesion developed. Pathological lesions with similar acid-fast organisms also were observed by us in rabbits given Freund complete adjuvant by two other investigators.
D000818:Animals; D005620:Freund's Adjuvant / Q000009:adverse effects*; D006099:Granuloma / Q000382:microbiology / Q000473:pathology; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D051379:Mice; D009161:Mycobacterium / Q000302:isolation & purification / Q000472:pathogenicity*; D009164:Mycobacterium Infections / Q000209:etiology / Q000382:microbiology / Q000473:pathology; D011817:Rabbits
D005620:Freund's Adjuvant