Binding and oxidation of amitriptyline and a series of its oxidized metabolites in liver microsomes from untreated and phenobarbital-treated rats.
D000639:Amitriptyline / Q000378:metabolism*; D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D008745:Methylation; D008862:Microsomes, Liver / Q000378:metabolism*; D009661:Nortriptyline / Q000378:metabolism; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology*; D011485:Protein Binding; D051381:Rats; D013053:Spectrophotometry; D013268:Stimulation, Chemical; D013329:Structure-Activity Relationship; D013997:Time Factors
D000639:Amitriptyline; D003577:Cytochrome P-450 Enzyme System; D009661:Nortriptyline; D010634:Phenobarbital