Variations in the responses of C57BL-10J and A-J mice to sheep red blood cells.
In response to repeated injections of sheep red blood cells, C57BL/10J mice produce predominantly 19S antibody in increasingly higher amounts, while A/J mice initially produce 19S antibody and then switch to produce increasing 7S antibody titers. In an F(1) generation all mice responded like the C57BL/10J mice. Backcross data implied genetic control involving at least three loci.
D000373:Agglutinins / Q000032:analysis; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002850:Chromatography, Gel; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D006460:Hemolysin Proteins / Q000032:analysis; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000276:immunology*; D012756:Sheep / Q000276:immunology
D000373:Agglutinins; D006460:Hemolysin Proteins; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M