Induction of deoxyribonucleic acid synthesis and the oncogenicity of Marek's disease virus.
Leukocytes recovered from birds inoculated with an oncogenic strain of Marek's disease virus synthesized deoxyribonucleic acid in vitro at a rate 7.9 times that of leukocytes from normal birds or birds inoculated with the nononcogenic herpesvirus of turkeys. A close relationship was observed between the level of in vitro deoxyribonucleic acid synthesis and in vivo tumor formation.
D000818:Animals; D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D002645:Chickens; D046508:Culture Techniques; D004247:DNA / Q000032:analysis / Q000096:biosynthesis*; D006564:Herpesviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D007962:Leukocytes / Q000032:analysis / Q000378:metabolism* / Q000382:microbiology; D008380:Marek Disease / Q000097:blood / Q000382:microbiology*; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014461:Ultracentrifugation
D002247:Carbon Isotopes; D014316:Tritium; D004247:DNA; D013936:Thymidine