Betamethasone 17-valerate and prednisolone 21-phosphate retention enemata in proctocolitis. A multicentre trial.
The efficacy of betamethasone 17-valerate (5 mg) and prednisolone 21-phosphate (20 mg) retention enemata in the outpatient treatment of distal proctocolitis was compared in a formal clinical trial. The two treatments were equally effective in inducing remissions of the disease, but the betamethasone valerate enema produced less adrenal suppression.
D000293:Adolescent; D000311:Adrenal Glands / Q000187:drug effects; D000328:Adult; D000368:Aged; D001623:Betamethasone / Q000008:administration & dosage* / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003864:Depression, Chemical; D004733:Enema; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage* / Q000378:metabolism; D011349:Proctitis / Q000188:drug therapy*; D012075:Remission, Spontaneous
D001623:Betamethasone; D011239:Prednisolone; D006854:Hydrocortisone