Effect of a delayed-action phenytoin preparation on blood phenytoin concentration.
In a cross-over study in a group of epileptic patients it was shown that replacement of the evening dose of an ordinary phenytoin preparation with the same phenytoin dose in a delayed-action preparation produced no significant change in the next morning's mean blood phenytoin concentration. However, replacement of the entire daily dose of an ordinary phenytoin preparation with the delayed-action preparation did increase mean blood phenytoin levels after some days, possibly because the latter preparation contained an additional 6% active drug, as compared with the former. In most circumstances, it seems doubtful if the delayed-action preparation offers any advantage over ordinary phenytoin in treating epilepsy.
D002849:Chromatography, Gas; D003692:Delayed-Action Preparations; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D010672:Phenytoin