title: An interim report on the production of colonic diverticula in the rabbit.
abstract: Six New Zealand white rabbits were given gas induction anaesthetics and maintained on glucochloralose (Merck) 60 mg/kg given intravenously. Intracolonic pressures were measured after a standard dose of prostigmine, 0.05 mg/kg, using fluid-filled, open-tipped, narrow-bore polythene tubes. Then the rabbits were put on a diet of white bread, butter, milk, and sugar supplemented by vitamins for four months. All six rabbits had put on weight but their general condition deteriorated; they had become constipated and the colon contracted. After stimulation with prostigmine 0.05 mg/kg scattered intertaenial wide-necked diverticula appeared which were thinner than the normal haustra and looked like a blackcurrant in colour, size, and shape. Repeat pressure measurements showed that the colonic motility index was increased up to 10 times from predietary levels with a highly significant mean increase from 5299 to 33151 (p < 0.0005).
mesh_terms: D000818:Animals; D001835:Body Weight; D001939:Bread; D002079:Butter; D002698:Chloralose; D003106:Colon / Q000473:pathology / Q000503:physiopathology; D003248:Constipation / Q000209:etiology; D004032:Diet; D004195:Disease Models, Animal; D004241:Diverticulum, Colon / Q000209:etiology*; D005769:Gastrointestinal Motility; D008365:Manometry; D008892:Milk; D009388:Neostigmine; D011817:Rabbits; D013395:Sucrose; D014815:Vitamins
chemical_list: D014815:Vitamins; D002698:Chloralose; D009388:Neostigmine; D013395:Sucrose; D002079:Butter