Metabolism of hydroanthracenones in rabbits.
1. The metabolism of 1-oxo-octahydro- and 2- and 9-oxoperhydro-anthracenes was investigated in rabbits. All compounds increased the urinary glucuronide content. 2. The 1-oxo and 2-oxo compounds were reduced to the corresponding alcohols whereas the 9-oxo compound was hydroxylated. 3. The reduction in vitro of these compounds and related ketones was investigated with three different enzyme systems (liver alcohol dehydrogenase, hydroxy steroid dehydrogenase, aromatic aldehyde-ketone reductase) in an attempt to explain the results in vivo. 4. Successful reduction of many ketones with aromatic aldehyde-ketone reductase suggests that the kidney may be of importance in the reduction in vivo of certain cyclic carbonyl compounds.
D000429:Alcohol Oxidoreductases; D000818:Animals; D000873:Anthracenes / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005965:Glucuronates / Q000652:urine; D006900:Hydroxylation; D006913:Hydroxysteroid Dehydrogenases; D007659:Ketones / Q000378:metabolism; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D007700:Kinetics; D010084:Oxidation-Reduction; D011817:Rabbits
D000873:Anthracenes; D005965:Glucuronates; D007659:Ketones; D000429:Alcohol Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases