Chromosome abnormalities in chronic active hepatitis.
An investigation on human peripheral blood lymphocyte chromosomes in chronic active hepatitis was carried out. A higher percentage of chromatid and chromosome lesions was recorded in all patients studied as compared with control groups-normal individuals, healthy subjects who had suffered from acute viral hepatitis, patients with alcoholic liver disease, and patients with mechanical jaundice due to cancer. The possible origin of these abnormalities is discussed.
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000782:Aneuploidy; D002842:Chromatids; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000235:genetics*; D006506:Hepatitis A / Q000235:genetics; D006801:Humans; D007565:Jaundice / Q000235:genetics; D008103:Liver Cirrhosis / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged; D011123:Polyploidy