Interactions of benzodiazepines with warfarin.
Administration of nitrazepam (10 mg nightly), diazepam (15 mg/day), and chlordiazepoxide (15 and 30 mg/day) had no effect on steady-state plasma warfarin concentrations, the plasma half-life of warfarin, or anticoagulant control in patients and it appears safe to prescribe these agents to patients on long-term oral anticoagulants. Urinary excretion of 6 beta-hydroxycortisol, however, increased in two out of five patients given chlordiazepoxide. In rats pretreatment with chlordiazepoxide (40 mg/kg for four days) caused stimulation of liver microsomal enzyme activity but neither diazepam nor nitrazepam had this effect.
D000328:Adult; D000368:Aged; D000818:Animals; D000925:Anticoagulants; D001552:Benzazepines / Q000008:administration & dosage*; D002707:Chlordiazepoxide / Q000008:administration & dosage*; D003975:Diazepam / Q000008:administration & dosage*; D004347:Drug Interactions; D005260:Female; D005938:Glucocorticoids / Q000652:urine; D006207:Half-Life; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008875:Middle Aged; D009567:Nitrazepam / Q000008:administration & dosage; D051381:Rats; D013997:Time Factors; D014149:Tranquilizing Agents / Q000008:administration & dosage*; D014859:Warfarin / Q000008:administration & dosage* / Q000097:blood
D000925:Anticoagulants; D001552:Benzazepines; D005938:Glucocorticoids; D014149:Tranquilizing Agents; D014859:Warfarin; D002707:Chlordiazepoxide; D009567:Nitrazepam; D003975:Diazepam; D006854:Hydrocortisone