Serum protein levels in primary biliary cirrhosis.
Serum levels of albumin, transferrin, alpha(2)-macroglobulin, beta(1)C/beta(1)A, IgA, IgG, and IgM have been determined in 73 patients with primary biliary cirrhosis and in age- and sex-matched controls. A highly significant fall in albumin was demonstrated, and there were highly significant increases in alpha(2)-macroglobulin and all three immunoglobulin levels. Transferrin and beta(1)/Cbeta(1)A levels were unchanged. No significant correlations were found between the titre of antimitochondrial antibody, the duration of symptoms, and any of the serum proteins estimated. A highly significant positive correlation was present between serum albumin and transferrin levels in both patient and control groups.
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008105:Liver Cirrhosis, Biliary / Q000097:blood* / Q000276:immunology; D008259:Macroglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis
D001323:Autoantibodies; D001798:Blood Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008259:Macroglobulins; D012709:Serum Albumin; D014168:Transferrin