Oxidation of nicotinic acid by a Bacillus species: regulation of nicotinic acid and 6-hydroxynicotinic acid hydroxylases.
The first two enzymes employed by a Bacillus species for the dissimilation of nicotinic acid are coordinately induced. The inducer of the enzymes appears to be 6-hydroxynicotinic acid, the product of the first enzyme in the pathways. Synthesis of the enzymes is repressed by glucose when ammonium is present in the medium, but not when nicotinic acid is the sole nitrogen source. The possible significance of the coordinate induction and unusual repression is discussed.
D001407:Bacillus / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D001565:Benzoates / Q000494:pharmacology; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002474:Cell-Free System; D002701:Chloramphenicol; D003470:Culture Media; D004790:Enzyme Induction / Q000187:drug effects; D004794:Enzyme Repression / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology; D006900:Hydroxylation; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009539:Nicotinic Acids / Q000378:metabolism* / Q000494:pharmacology; D010084:Oxidation-Reduction; D011725:Pyridines / Q000494:pharmacology; D013053:Spectrophotometry
D001565:Benzoates; D002247:Carbon Isotopes; D003470:Culture Media; D009539:Nicotinic Acids; D011725:Pyridines; D002245:Carbon Dioxide; D002701:Chloramphenicol; D006899:Mixed Function Oxygenases; D005947:Glucose