Acetoxycycloheximide enhances audiogenic seizures in DBA-2J mice.
Inborn errors of metabolism often cause epilepsy, as with certain strains of mice. Aggravating the metabolic defect with a protein synthesis inhibitor increases the symptoms. Mature animals that have "outgrown" their genetic susceptibility to audiogenic seizures are made susceptible again by acetoxycycloheximide. After a single small dose the incidence and severity of audiogenic seizures increases at 16 hours, reaches a maximum of 40 hours, and then declines gradually.
D000367:Age Factors; D000818:Animals; D008661:Metabolism, Inborn Errors / Q000150:complications; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D011728:Pyridones / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000150:complications / Q000209:etiology; D013016:Sound; D013997:Time Factors
D011728:Pyridones; D006899:Mixed Function Oxygenases