Screening for malignant hyperpyrexia.
The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium.
D000138:Acidosis; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis*; D008403:Mass Screening; D008722:Methods; D008854:Microscopy, Electron; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000473:pathology; D013390:Succinylcholine / Q000494:pharmacology
D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase; D013390:Succinylcholine; D006221:Halothane