Prostaglandin-like activity in ocular inflammation.
Aqueous humour samples from untreated patients with acute anterior uveitis were found to contain substantial amounts of prostaglandin-like activity. Little activity was found in aqueous from patients treated with steroids, and none (<2 ng/ml) was detected in aqueous from the uninflamed eyes of patients with cataract. Alkaline hydrolysis of the samples from inflamed eyes suggested the presence of both E and F prostaglandin-like activity. These results show that prostaglandins may be involved in acute anterior uveitis.
D000468:Alkalies; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001681:Biological Assay; D002386:Cataract / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000187:drug effects; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013256:Steroids / Q000627:therapeutic use; D013270:Stomach / Q000187:drug effects; D014605:Uveitis / Q000188:drug therapy / Q000378:metabolism*
D000468:Alkalies; D011453:Prostaglandins; D013256:Steroids