title: Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim.
abstract: Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18.5% were resistant to sulphamethoxazole and 1.6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on average more resistant to sulphamethoxazole than were trimethoprim-sensitive strains. They were all resistant to several other antimicrobial agents. Most of them had the phage-typing pattern 84/85, 84, or 85.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001414:Bacitracin / Q000494:pharmacology; D001434:Bacteriophage Typing; D004352:Drug Resistance, Microbial; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D005672:Fusidic Acid / Q000494:pharmacology; D006801:Humans; D008034:Lincomycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology; D009827:Oleandomycin; D010403:Penicillin Resistance; D011743:Pyrimidines / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013449:Sulfonamides; D001414:Bacitracin; D005672:Fusidic Acid; D014295:Trimethoprim; D008034:Lincomycin; D013752:Tetracycline; D009355:Neomycin; D013420:Sulfamethoxazole; D009827:Oleandomycin; D013307:Streptomycin