Glomerular filtration rate and renal plasma flow in long-term juvenile diabetics without proteinuria.
Glomerular filtration rate and renal plasma flow were examined in 16 young male non-proteinuric diabetics (mean age 28.4 years) with a duration of diabetes of over 15 years (mean duration 21.5 years.) In this selected group of long-term diabetics the glomerular filtration rate was clearly increased, the mean being 136 ml/min (+/-S.D. 11.8) (normal value 114 ml/min (+/-14.1), being comparable to that found earlier in short-term diabetics. There was no change in renal plasma flow. It is concluded that kidney function is generally well preserved in long-term diabetics who have not developed proteinuria.
D000328:Adult; D001786:Blood Glucose; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005919:Glomerular Filtration Rate; D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007483:Iothalamic Acid; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D011507:Proteinuria; D012039:Regional Blood Flow
D001786:Blood Glucose; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid; D007483:Iothalamic Acid