A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.
1. Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.2. The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.3. Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology*; D003986:Dibenzocycloheptenes / Q000494:pharmacology*; D004123:Dimethylamines / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008433:Mathematics; D009119:Muscle Contraction / Q000187:drug effects; D009888:Opipramol / Q000494:pharmacology*; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects*
D003986:Dibenzocycloheptenes; D004123:Dimethylamines; D010276:Parasympatholytics; D000639:Amitriptyline; D001285:Atropine; D002217:Carbachol; D009888:Opipramol; D003891:Desipramine