title: In-situ and invasive carcinoma of the colon in patients with ulcerative colitis.
abstract: Four cases are described in which ulcerative colitis was complicated by carcinoma and in which the extent of the accompanying in-situ carcinoma (precancer) was determined. The extent of the in-situ carcinoma was very variable and in all cases the rectum was spared in whole or part. Search for in-situ carcinoma in rectal biopsies will fail to indicate the development of malignancy in some patients with ulcerative colitis. Alternative methods of cancer detection in this group are discussed.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002278:Carcinoma in Situ / Q000150:complications / Q000473:pathology; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000473:pathology; D012809:Colon, Sigmoid / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa; D008297:Male; D012007:Rectum / Q000473:pathology