Euglena gracilis: formation of giant mitochondria.
The addition of antimycin A (0.5 microgram per milliliter) to cultures of a bleached strain of Euglena gracilis in the logarithmic phase of growth on succinate as a carbon source results in (i) an interruption of growth for 24 hours and (ii) an increase in whole-cell respiration and the emergence of a novel succinoxidase activity within 2 to 4 hours. After 3 to 5 hours, the mitochondria enlarge, fuse, and form a sheathlike structure situated close to the periphery of the cell.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000968:Antimycin A / Q000494:pharmacology*; D002458:Cell Fractionation; D005055:Euglena / Q000187:drug effects / Q000254:growth & development; D008928:Mitochondria / Q000187:drug effects*; D008933:Mitochondrial Swelling; D010101:Oxygen Consumption; D013385:Succinate Dehydrogenase; D013997:Time Factors
D000249:Adenosine Monophosphate; D000968:Antimycin A; D013385:Succinate Dehydrogenase