The carcinogenicity of two diazadibenzopyrenes.
1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive.
D000818:Animals; D001372:Aza Compounds / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology*; D002273:Carcinogens; D007279:Injections, Subcutaneous; D051379:Mice; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013329:Structure-Activity Relationship
D001372:Aza Compounds; D001580:Benzopyrenes; D002273:Carcinogens