HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy.
Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.
D000328:Adult; D000368:Aged; D002446:Celiac Disease / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D003874:Dermatitis Herpetiformis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D005983:Glutens; D006649:Histocompatibility Antigens; D006801:Humans; D008875:Middle Aged; D010641:Phenotype; D013450:Sulfones / Q000627:therapeutic use
D006649:Histocompatibility Antigens; D013450:Sulfones; D005983:Glutens