Hemoglobin Lepore trait: globin synthesis in bone marrow and peripheral blood.
There was decreased synthesis of the beta-globin chain in the peripheral blood, and equal synthesis of alpha- and non-alpha-chains in the bone marrow of three patients with hemoglobin Lepore trait, similar to the findings in patients with heterozygous beta-thalassemia. There is a relative instability of the synthetic mechanism for normal beta-chain in these patients.
D001853:Bone Marrow / Q000378:metabolism*; D002247:Carbon Isotopes; D002845:Chromatography; D005914:Globins / Q000032:analysis / Q000096:biosynthesis*; D006453:Hemoglobinopathies / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007930:Leucine / Q000378:metabolism; D013789:Thalassemia / Q000378:metabolism
D002247:Carbon Isotopes; D005914:Globins; D007930:Leucine