Renal excretion of metolazone, a new diuretic.
1. Metolazone, a new diuretic, was found to be excreted by glomerular filtration and renal tubular secretion.2. The secretory mechanism was antagonized by probenecid but this did not affect the diuretic action of metolazone.
D000818:Animals; D002247:Carbon Isotopes; D003404:Creatinine / Q000097:blood / Q000652:urine; D004232:Diuretics / Q000097:blood / Q000652:urine*; D004285:Dogs; D007659:Ketones / Q000097:blood / Q000652:urine; D007677:Kidney Function Tests; D011339:Probenecid / Q000494:pharmacology; D011799:Quinazolines / Q000097:blood / Q000652:urine*; D013449:Sulfonamides / Q000097:blood / Q000652:urine*
D002247:Carbon Isotopes; D004232:Diuretics; D007659:Ketones; D011799:Quinazolines; D013449:Sulfonamides; D003404:Creatinine; D011339:Probenecid