title: Further studies on the effect of ageing on beta-adrenoceptor activity of rat aorta.
abstract: beta-Adrenoceptor activity of rat thoracic aorta decreased with the increasing age of the animal. The ability of aortas to relax to isoprenaline was completely lost when rats were 3-6 months old, depending on the source and strain of animals. NaNO(2), however, completely relaxed aortic tissue from animals of all ages tested.
mesh_terms: D000375:Aging; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology*; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009573:Nitrites / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D012701:Serotonin / Q000494:pharmacology
chemical_list: D009573:Nitrites; D011941:Receptors, Adrenergic; D011955:Receptors, Drug; D012701:Serotonin; D007545:Isoproterenol; D010646:Phentolamine