title: Diurnal variation of HMG CoA reductase activity in rat intestine.
abstract: HMG CoA reductase activity of rat intestinal mucosa has a diurnal rhythm which coincides with the diurnal variation of the hepatic HMG CoA reductase but has a lower amplitude. The rhythmic variation of the intestinal reductase was present in both jejunal and ileal crypt cell microsomes and was not abolished by cholestyramine administration.
mesh_terms: D000429:Alcohol Oxidoreductases; D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D002792:Cholestyramine Resin / Q000494:pharmacology; D002940:Circadian Rhythm; D005977:Glutarates; D007082:Ileum / Q000201:enzymology; D007422:Intestines / Q000187:drug effects / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008798:Mevalonic Acid; D008861:Microsomes / Q000201:enzymology; D051381:Rats
chemical_list: D005977:Glutarates; D002792:Cholestyramine Resin; D002784:Cholesterol; D000429:Alcohol Oxidoreductases; D008798:Mevalonic Acid