Action of bradykinin potentiating factor (BPF) and dimercaprol (BAL) on the responses to bradykinin of isolated preparations of rat intestines.
BPF and BAL inhibited kininase activity of homogenates of rat intestine. However, BFP potentiated and BAL inhibited the contractions induced by bradykinin on rat isolated duodenum (low calcium solution) and terminal ileum (normal calcium solution). Neither BPF nor BAL affects the relaxation induced by bradykinin of rat duodenum bathed in normal Tyrode. These results suggest that two different types of pharmacological receptor are involved in the action of bradykinin on rat intestine, and that other factors besides the inhibition of agonist destruction participate in the mechanism of potentiation of kinin action by BPF.
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D003864:Depression, Chemical; D004112:Dimercaprol / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D007082:Ileum / Q000187:drug effects / Q000201:enzymology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug
D010455:Peptides; D011955:Receptors, Drug; D004112:Dimercaprol; D001920:Bradykinin