title: Changes in structure and peptidase activity of rat small intestine induced by prednisolone.
abstract: Chronic dietary administration of prednisolone to the adult rat caused alteration in morphology and enzyme activity of the small intestinal mucosa. Reduction of villous height, crypt depth, and surface epithelial cell height was accompanied by a significant increase in the specific activity of several jejunal peptidases.
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D005260:Female; D006651:Histocytochemistry; D007082:Ileum / Q000201:enzymology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000201:enzymology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D007583:Jejunum / Q000166:cytology / Q000201:enzymology; D008854:Microscopy, Electron; D010447:Peptide Hydrolases / Q000378:metabolism*; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D011239:Prednisolone; D010447:Peptide Hydrolases