The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.
The porphyrinogenic drug 2-allyl-2-isopropylacetamide causes the degradation of microsomal cytochrome P-450 and inhibits the synthesis of catalase in rat liver. The inhibition of catalase synthesis follows the induction of delta-aminolaevulinate synthetase and the consequent overproduction of haem. The allylisopropylacetamide-mediated breakdown of cytochrome P-450 is a rapid event and has a reciprocal relationship to the pattern of delta-aminolaevulinate synthetase induction. Breakdown of cytochrome P-450 appears to be one of the conditions leading to the ;derepression' of delta-aminolaevulinate synthetase.
D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis*; D000577:Amides / Q000494:pharmacology; D000818:Animals; D001663:Bilirubin / Q000494:pharmacology; D002374:Catalase / Q000096:biosynthesis*; D003513:Cycloheximide / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006207:Half-Life; D006418:Heme / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D011166:Porphyrins / Q000378:metabolism; D011335:Proadifen / Q000494:pharmacology; D051381:Rats
D000577:Amides; D011166:Porphyrins; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D003513:Cycloheximide; D011335:Proadifen; D002374:Catalase; D000624:5-Aminolevulinate Synthetase; D005947:Glucose; D001663:Bilirubin; D010634:Phenobarbital