A method for assessing dihydrofolate reductase inhibition in vivo.
D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D004355:Drug Stability; D005492:Folic Acid / Q000032:analysis / Q000138:chemical synthesis / Q000378:metabolism; D005493:Folic Acid Antagonists; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008433:Mathematics; D008722:Methods; D008727:Methotrexate; D051379:Mice; D008815:Mice, Inbred Strains; D013057:Spectrum Analysis; D013762:Tetrahydrofolate Dehydrogenase / Q000032:analysis*; D013997:Time Factors; D014316:Tritium; D014466:Ultraviolet Rays
D005493:Folic Acid Antagonists; D014316:Tritium; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate