title: Induction of deoxyribonucleic acid synthesis and the oncogenicity of Marek's disease virus.
abstract: Leukocytes recovered from birds inoculated with an oncogenic strain of Marek's disease virus synthesized deoxyribonucleic acid in vitro at a rate 7.9 times that of leukocytes from normal birds or birds inoculated with the nononcogenic herpesvirus of turkeys. A close relationship was observed between the level of in vitro deoxyribonucleic acid synthesis and in vivo tumor formation.
mesh_terms: D000818:Animals; D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D002645:Chickens; D046508:Culture Techniques; D004247:DNA / Q000032:analysis / Q000096:biosynthesis*; D006564:Herpesviridae / Q000302:isolation & purification / Q000472:pathogenicity*; D007962:Leukocytes / Q000032:analysis / Q000378:metabolism* / Q000382:microbiology; D008380:Marek Disease / Q000097:blood / Q000382:microbiology*; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014461:Ultracentrifugation
chemical_list: D002247:Carbon Isotopes; D014316:Tritium; D004247:DNA; D013936:Thymidine