The detection of fibrinogen-fibrin degradation products by means of a new antibody-coated latex particle.
A rapid slide test for the detection of degradation products of fibrinogen/fibrin (FDP) using a new antibody-coated latex particle is described. The latex particle has been specifically coated with antibody to fragments D and E. The latex agglutination test (Thrombo-Wellcotest) has been compared with the tanned red cell haemagglutination inhibition immunoassay (TRCHII) in 143 patients with a variety of clinical conditions. There is a high degree of agreement between the methods with a coefficient of correlation of 0.83. The method provides a rapid, simple screening test for fibrin degradation products.
D000906:Antibodies; D005337:Fibrin / Q000032:analysis* / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis* / Q000378:metabolism; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism; D007840:Latex; D008107:Liver Diseases / Q000378:metabolism; D008722:Methods; D008863:Microspheres; D009369:Neoplasms / Q000378:metabolism; D011655:Pulmonary Embolism / Q000378:metabolism
D000906:Antibodies; D007840:Latex; D005337:Fibrin; D005340:Fibrinogen