Alcohol dependence and opiate dependence: lack of relationship in mice.
According to a recently proposed hypothesis, physical dependence upon alcohol is due to the formation of an endogenous opiate. We tested the hypothesis by determining whether or not ethanol-dependent mice would show typical opiate-dependent behavior (withdrawal jumping syndrome) when challenged with the opiate antagonist naloxone. Our results do not support the hypothesis.
D000437:Alcoholism / Q000209:etiology*; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000097:blood; D006801:Humans; D007546:Isoquinolines / Q000096:biosynthesis; D008297:Male; D051379:Mice; D009019:Morphinans / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders
D007546:Isoquinolines; D009019:Morphinans; D000431:Ethanol; D004298:Dopamine