title: Growth of Aerobacter aerogenes on D-arabinose: origin of the enzyme activities.
abstract: Mutants of Aerobacter aerogenes can be selected which are capable of utilizing d-arabinose as a sole source of carbon and energy for growth. Mutants can also be selected which are capable of using l-xylose. The mutational event permitting the utilization of d-arabinose results in the constitutive synthesis of certain enzymes of the l-fucose catabolic pathway. l-Fucose isomerase catalyzes the first reaction in the degradation of d-arabinose: the isomerization of d-arabinose to d-ribulose. No other type of mutation appears to be required to initiate growth on d-arabinose, and wild-type cells induced for the enzymes of the l-fucose catabolic pathway are capable of growth on d-arabinose. The first reaction in the catabolism of l-xylose, the isomerization of l-xylose to l-xylulose, also appears to be catalyzed by constitutively synthesized l-fucose isomerase.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D001089:Arabinose / Q000378:metabolism*; D002241:Carbohydrates / Q000096:biosynthesis; D002247:Carbon Isotopes; D002364:Caseins; D002474:Cell-Free System; D003470:Culture Media; D004754:Enterobacter / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development / Q000378:metabolism; D005643:Fucose / Q000378:metabolism; D005827:Genetics, Microbial; D007535:Isomerases / Q000378:metabolism*; D007536:Isomerism; D009153:Mutagens; D009154:Mutation; D009604:Nitrosoguanidines; D010428:Pentosephosphates / Q000096:biosynthesis; D010770:Phosphotransferases / Q000378:metabolism; D011492:Protein Hydrolysates; D013053:Spectrophotometry; D013237:Stereoisomerism; D013402:Sugar Alcohols; D013997:Time Factors; D014994:Xylose / Q000378:metabolism
chemical_list: D002241:Carbohydrates; D002247:Carbon Isotopes; D002364:Caseins; D003470:Culture Media; D009153:Mutagens; D009604:Nitrosoguanidines; D010428:Pentosephosphates; D011492:Protein Hydrolysates; D013402:Sugar Alcohols; D005643:Fucose; D014994:Xylose; D001089:Arabinose; D000429:Alcohol Oxidoreductases; D010770:Phosphotransferases; D007535:Isomerases