An ultrastructural study of the effect of neomycin on the colon in the human subject and in the conventional and the germ-free mouse.
An electron microscopic study of the colon of normal mice and human subjects and those treated with neomycin is reported; there is a close resemblance between the mouse and human colons. After rapid disinfection of the colon, there is epithelial cell damage due to a toxic effect of the drug, a reduction in epithelial turnover accompanying the change in flora, and an important reduction in the cellularity of the lamina propria mainly due to a reduction in inflammatory cells. The changes in the lamina propria probably represent changes in the antipathogenetic defences of the host.
D000818:Animals; D001485:Basement Membrane; D002432:Cecum / Q000473:pathology; D002467:Cell Nucleus; D003094:Collagen; D003106:Colon / Q000187:drug effects* / Q000382:microbiology / Q000473:pathology; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D005347:Fibroblasts; D005856:Germ-Free Life; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D009355:Neomycin / Q000494:pharmacology*; D009417:Nerve Tissue / Q000473:pathology
D003094:Collagen; D009355:Neomycin