title: Direct effects on the membrane potential due to "pumps" that transfer no net charge.
abstract: The effects of active ionic transport are included in the derivation of a general expression for the zero current membrane potential. It is demonstrated that an active transport system that transfers no net charge (nonrheogenic) may, nevertheless, directly alter the membrane potential. This effect depends upon the exchange of matter within the membrane between the active and passive diffusion regimes. Furthermore, in the presence of such exchange, the transmembrane active fluxes measured by the usual techniques and the local pumped fluxes are not identical. Several common uses of the term "electrogenic pump" are thus shown to be inconsistent with each other. These inconsistencies persist when the derivation is extended to produce a Goldman equation modified to account for active transport; however, that equation is shown to be limited by less narrow constraints on membrane heterogeneity and internal electric field than those previously required. In particular, it is applicable to idealized mosaic membranes limited by these requirements.
mesh_terms: D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D004058:Diffusion; D007474:Ion Exchange; D008564:Membrane Potentials; D008954:Models, Biological; D011199:Potentiometry