Origin of 5-hydroxyindoleacetic acid in the spinl fluid.
5-Hydroxyindoleacetic acid applied intracisternally in cats does not appear in spinal fluid. Changes of 5-hydroxyindoleacetic acid concentration in the spinal cord are clearly reflected in the perfusate of the spinal subarachnoid space. Thus, 5-hydroxyindoleacetic acid in the spinal fluid originates from the spinal cord and reflects metabolic changes of 5-hydroxytryptamine in the spinal tissue, but not those in the brain.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002415:Cats; D006897:Hydroxyindoleacetic Acid / Q000008:administration & dosage / Q000032:analysis / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid*; D007278:Injections, Spinal; D010477:Perfusion; D012701:Serotonin / Q000032:analysis / Q000378:metabolism; D013116:Spinal Cord / Q000032:analysis / Q000378:metabolism; D013346:Subarachnoid Space; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid