title: Marihuana: standardized smoke administration and dose effect curves on heart rate in humans.
abstract: A spirometer was used to deliver marihuana and placebo smoke to human subjects. This procedure produced linear dose-effect curves on heart rate and replicable dose effects in individual subjects. No differences were observed between experienced and inexperienced smokers in responsiveness to heart rate increases produced by marihuana.
mesh_terms: D000328:Adult; D002188:Cannabis / Q000008:administration & dosage / Q000494:pharmacology*; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010919:Placebos; D013147:Spirometry; D014636:Valsalva Maneuver
chemical_list: D010919:Placebos