Immunosuppression by platinum diamines.
Platinum diamine dichloride and tetrachloride inhibit the formation of antibody-forming cells in the mouse spleen after injection of sheep red cells. The dichloride is the more effective agent. It acts best when given 2 days after the antigen, which suggests that cells are more sensitive to its action when they are rapidly proliferating than when they are resting. Its dose-response curve is exponential, suggesting that its action is like that of an alkylating agent. Platinum ethylene diamines were relatively ineffective in this system.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D000941:Antigens; D002455:Cell Division; D002712:Chlorides / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005029:Ethylenediamines / Q000494:pharmacology; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D010984:Platinum / Q000494:pharmacology*; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects
D000588:Amines; D000941:Antigens; D002712:Chlorides; D005029:Ethylenediamines; D010984:Platinum