Erythroid cell differentiation and the inhibition of cytokinesis by cytochalasin.
Cytochalasin B produces multinucleated erythroid cells in tissue cultures of very young chick blastoderms. There is no apparent qualitative interference with differentiation and maturation of erythroid cells, but the amounts produced are reduced 4- and 10-fold. These effects of cytochalasin are readily reversible.
D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D002642:Chick Embryo; D046508:Culture Techniques; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects*; D005855:Germ Layers / Q000032:analysis / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis / Q000037:antagonists & inhibitors; D008722:Methods; D009183:Mycotoxins / Q000494:pharmacology*; D013997:Time Factors
D006454:Hemoglobins; D009183:Mycotoxins