Histological findings in pseudomembranous trigonitis.
Pseudomembranous trigonitis presents in females with the urethral syndrome and a characteristic lesion restricted to the trigone of the bladder. The histology shows ;vaginal metaplasia' of the epithelium together with underlying oedema and vascular dilatation, but no significant inflammation. Thirty-one such cases are included in the study. The possible role of oestrogen stimulation is discussed, together with a suggestion that the trigone has an embryological derivation distinct from the remainder of the bladder, allowing the trigonal epithelium to respond to oestrogenic stimulation in a manner denied to the vesical transitional epithelium.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001808:Blood Vessels / Q000473:pathology; D003556:Cystitis / Q000473:pathology*; D004106:Dilatation; D004487:Edema; D004848:Epithelium / Q000473:pathology; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D014526:Urethritis / Q000473:pathology*; D001743:Urinary Bladder / Q000196:embryology / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000473:pathology*; D014552:Urinary Tract Infections / Q000473:pathology; D014621:Vagina
D004967:Estrogens