title: ( 3 H)lysergic acid diethylamide: cellular autoradiographic localization in rat brain.
abstract: Intravenous administration of [(3)H]lysergic acid diethylamide(LSD) to rats resulted in accumulation of the drug in the brain within 15 minutes. Autoradiographic methods were used to differentiate free and bound [(3)H]LSD in brain tissue. Free [(3)H]LSD was generally distributed in the pituitary and pineal glands, cerebellum, hippocampus,and choroid plexus. Bound [(3)H]LSD was localized in neurons of the cortex, caudate nucleus, midbrain, and medulla,as well as in choroid plexus epithelium.
mesh_terms: D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000032:analysis; D002531:Cerebellum / Q000032:analysis; D002540:Cerebral Cortex / Q000032:analysis; D002831:Choroid Plexus / Q000032:analysis; D005612:Freeze Drying; D006624:Hippocampus / Q000032:analysis; D006651:Histocytochemistry; D007275:Injections, Intravenous; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D008636:Mesencephalon / Q000032:analysis; D009847:Olivary Nucleus / Q000032:analysis; D010870:Pineal Gland / Q000032:analysis; D010902:Pituitary Gland / Q000032:analysis; D011689:Purkinje Cells / Q000032:analysis; D051381:Rats; D013477:Superior Colliculi / Q000032:analysis; D013681:Tegmentum Mesencephali / Q000032:analysis; D013997:Time Factors; D014316:Tritium
chemical_list: D014316:Tritium; D008238:Lysergic Acid Diethylamide