The cytotoxicity of methotrexate in mouse small intestine in relation to inhibition of folic acid reductase and of DNA synthesis.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D004847:Epithelial Cells; D005493:Folic Acid Antagonists; D007413:Intestinal Mucosa / Q000187:drug effects; D007421:Intestine, Small / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology; D008297:Male; D008727:Methotrexate / Q000633:toxicity*; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009929:Organ Size; D010710:Phosphates / Q000378:metabolism; D010759:Phosphorus Isotopes; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D005493:Folic Acid Antagonists; D010710:Phosphates; D010759:Phosphorus Isotopes; D014316:Tritium; D004247:DNA; D013936:Thymidine; D014529:Uridine; D008727:Methotrexate