Lymphocyte DNA synthesis inhibition.
A specific endogenous inhibitor for lymphocyte DNA synthesis that can be isolated from the lymphoid system and which is probably cell specific is described. The inhibitor is thermolabile, is destroyed by trypsin, and has a mass of about 30,000 to 50,000 daltons.
D000818:Animals; D002247:Carbon Isotopes; D002417:Cattle; D002648:Child; D004247:DNA / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000494:pharmacology; D007945:Leukemia, Lymphoid / Q000378:metabolism; D008198:Lymph Nodes / Q000032:analysis; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008221:Lymphoid Tissue / Q000032:analysis*; D008970:Molecular Weight; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000032:analysis; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000032:analysis; D014020:Tissue Extracts / Q000494:pharmacology; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D002247:Carbon Isotopes; D037102:Lectins; D014020:Tissue Extracts; D014316:Tritium; D010649:Phenylalanine; D004247:DNA; D013936:Thymidine; D014529:Uridine