title: Dopamine: release from the brain in vivo by amantadine.
abstract: After dopamine stores in the caudate nucleus of cats were labeled with [(3)H]dopamine, the ventricular system was perfused with artificial cerebrospinal fluid. The addition of amantadine to the perfusing fluid caused a doserelated increase in the concentrations of [(3)H]dopamine appearing in the perfusion effluent. Subthreshold concentrations of amantadine also enhanced the efflux of [(3)H]dopamine induced by electrical stimulation of the caudate nucleus.
mesh_terms: D000547:Amantadine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002415:Cats; D002421:Caudate Nucleus / Q000032:analysis / Q000502:physiology; D002552:Cerebral Ventricles / Q000378:metabolism; D004298:Dopamine / Q000008:administration & dosage / Q000378:metabolism*; D004558:Electric Stimulation; D010477:Perfusion; D014316:Tritium
chemical_list: D014316:Tritium; D000547:Amantadine; D004298:Dopamine