Microbiological study of copiamycin.
Copiamycin, an antibiotic agent, has shown in vitro activity against Candida albicans, Torulopsis glabrata, and Trichomonas vaginalis. Local administration of copiamycin to mice inoculated intraperitoneally with protozoa reduced the per cent of infection as measured by decreased abscess formation. This antibiotic has had little effect on the glucose oxidation by protozoa. Its action on anaerobic glucose metabolism in these organisms was equal to that of aminitrozole and azalomycin F. From these results we conclude that copiamycin is an effective antifungal and antitrichomonal agent equivalent in activity to azalomycin F.
D000693:Anaerobiosis; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D004352:Drug Resistance, Microbial; D005947:Glucose / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use; D007773:Lactates / Q000096:biosynthesis; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use; D008365:Manometry; D051379:Mice; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000254:growth & development; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D014244:Trichomonas / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014245:Trichomonas Infections / Q000517:prevention & control
D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D003470:Culture Media; D006146:Guanidines; D007773:Lactates; D007783:Lactones; D005947:Glucose