Rubidium and lithium: opposite effects on amine-mediated excitement.
In mice the activation caused by morphine was antagonized by previous treatment with lithium and was potentiated by previous treatment with rubidium. Other antimanic drugs antagonized the morphine activation as well. The effect of rubidium was similar to that of the antidepressant drugs imipramine and pargyline. Rubidium may merit clinical evaluation as an antidepressant agent in man.
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D004195:Disease Models, Animal; D004336:Drug Antagonism; D004357:Drug Synergism; D006801:Humans; D008094:Lithium; D008297:Male; D051379:Mice; D008960:Models, Psychological; D009020:Morphine / Q000037:antagonists & inhibitors*; D009043:Motor Activity / Q000187:drug effects; D011596:Psychomotor Disorders / Q000139:chemically induced*; D012413:Rubidium / Q000494:pharmacology* / Q000627:therapeutic use
D000928:Antidepressive Agents; D009020:Morphine; D008094:Lithium; D012413:Rubidium