Binding of DDT to lecithin.
An interaction between DDT and lecithin is indicated by the reciprocal effects of each compound on the proton magnetic resonance spectrum of the other. The phosphoryl choline moiety of the lecithin and the benzylic proton of the DDT seem to be involved. The most pronounced response in the proton magnetic resonance spectrum of the lecithin produced by increasing concentration s of DDT was a change in the chemical shift of the resonance peak due to the protons of the choline methyl groups. Increasing concentrations of lecithin produced changes in the chemical shift of the resonance peaks of the benzylic proton and adjacent ring protons of the DDT. Equilibrium constant of 0.597 +/-0.015 molal(-1) was obtained for this interaction.
D003634:DDT / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000378:metabolism / Q000494:pharmacology*; D012997:Solvents; D013696:Temperature
D010713:Phosphatidylcholines; D012997:Solvents; D003634:DDT