Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat.
Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002845:Chromatography; D005470:Fluorometry; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium; D014364:Tryptophan / Q000032:analysis / Q000378:metabolism
D014316:Tritium; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide