Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide. I. Action on succinate dehydrogenase and TCA-cycle oxidations.
D000090:Acetoacetates / Q000096:biosynthesis; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002245:Carbon Dioxide / Q000096:biosynthesis; D002247:Carbon Isotopes; D002331:Carnitine / Q000378:metabolism; D002952:Citric Acid Cycle / Q000187:drug effects*; D003981:Diazoxide / Q000494:pharmacology*; D005420:Flavoproteins / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007700:Kinetics; D008293:Malates / Q000494:pharmacology; D008297:Male; D008314:Malonates / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D010101:Oxygen Consumption; D010169:Palmitic Acids / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013053:Spectrophotometry; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*; D014475:Uncoupling Agents / Q000494:pharmacology
D000090:Acetoacetates; D002247:Carbon Isotopes; D005420:Flavoproteins; D007328:Insulin; D008293:Malates; D008314:Malonates; D010169:Palmitic Acids; D011773:Pyruvates; D014475:Uncoupling Agents; D002245:Carbon Dioxide; D000244:Adenosine Diphosphate; D013385:Succinate Dehydrogenase; D003981:Diazoxide; D002331:Carnitine