Human red blood cells: prostaglandin E2, epinephrine, and isoproterenol alter deformability.
The human red blood cell responds to prostaglandin E(2), epinephrine, and isoproterenol with a decrease in deformability. The maximum decrease is brought about by 10(-10)M prostaglandin E(2), 10(-9)M epinephrine, or 10(-7)M isoproterenol. The dose response curve is biphasic. The sensitivity of the red cell to prostaglandin suggests that this cell may be a primary target for prostaglandin action. These changes in response to vasoactive substances indicate that the red cell must be considered an active element in circulatory control.
D001809:Blood Viscosity / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects*; D005374:Filtration; D006400:Hematocrit; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*
D011453:Prostaglandins; D007545:Isoproterenol; D004837:Epinephrine