Lymphocyte sensitization to nervous tissues and muscle in patients with the Guillain-Barré syndrome.
By means of an electrophoretic method lymphocytes from patients with the Guillain-Barré syndrome (`acute idiopathic polyneuritis') have been shown to be sensitized to both encephalitogenic factor (EF) and a similar basic protein prepared from human sciatic nerve (SNBP). Sensitization was more marked in the acute stage of the disorder during which there also appeared to be a degree of sensitization to muscle. The results are consistent with the view that lymphocytic infiltration of peripheral nerves in the condition is of pathogenetic significance.
D000328:Adult; D000368:Aged; D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D004586:Electrophoresis; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D010525:Peripheral Nerves / Q000276:immunology; D011115:Polyneuropathies / Q000276:immunology; D011128:Polyradiculopathy / Q000209:etiology / Q000276:immunology*
D000961:Antilymphocyte Serum; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins