title: Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat.
abstract: Lysergic acid diethylamide at doses of 20 micrograms per kilogram per day was administered orally to rats for I month. Eighteen hours after the final dose a 25 to 30 percent increase in the synthesis and turnover of serotonin was noted, as well as a moderate but significant increase in the concentration of tryptophan (18 percent) and serotonin (13 percent) in the brain.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002845:Chromatography; D005470:Fluorometry; D006897:Hydroxyindoleacetic Acid / Q000032:analysis; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000096:biosynthesis / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium; D014364:Tryptophan / Q000032:analysis / Q000378:metabolism
chemical_list: D014316:Tritium; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D008238:Lysergic Acid Diethylamide