Importance of the sympathetic nervous system in the development of renal hypertension in the rat.
1. Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain.2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries.3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them.4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment.5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment.6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.
D000311:Adrenal Glands / Q000502:physiology; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D002395:Catecholamines / Q000032:analysis; D004837:Epinephrine / Q000494:pharmacology; D006977:Hypertension, Renal / Q000209:etiology / Q000503:physiopathology*; D007275:Injections, Intravenous; D008297:Male; D009206:Myocardium / Q000032:analysis; D009638:Norepinephrine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D010991:Plethysmography; D051381:Rats; D012077:Renal Artery / Q000502:physiology; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors
D002395:Catecholamines; D010627:Phenethylamines; D009638:Norepinephrine; D004837:Epinephrine