DDT administered to neonatal rats induces persistent estrus syndrome.
The o,p'-isomer of the insecticide DDT when injected into neonatal female rats significantly advanced puberty, induced persistent vaginal estrus after a period of normal estrous cycles, and caused the ovaries to develop follicular cysts and a reduced number of corpora lutea. The uterotropic response to administered estradiol was reduced, and the female pattern of mating behavior was slightly disturbed. Residues of DDT in ovarian, brain, and adipose tissues of the adult animals were the same in both treated and control groups.
D000273:Adipose Tissue / Q000032:analysis; D000367:Age Factors; D000818:Animals; D001923:Brain Chemistry; D003634:DDT / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D007279:Injections, Subcutaneous; D009929:Organ Size; D010048:Ovarian Cysts / Q000139:chemically induced; D010053:Ovary / Q000032:analysis / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects; D014599:Uterus; D014621:Vagina / Q000187:drug effects
D003634:DDT