title: Mendelian and uniparental alterations in erythromycin binding by plastid ribosomes.
abstract: Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.
mesh_terms: D001665:Binding Sites; D002247:Carbon Isotopes; D002458:Cell Fractionation; D002499:Centrifugation, Density Gradient; D000460:Chlorophyta / Q000378:metabolism*; D002736:Chloroplasts / Q000378:metabolism; D003433:Crosses, Genetic; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000378:metabolism* / Q000494:pharmacology; D056890:Eukaryota / Q000187:drug effects; D005827:Genetics, Microbial; D009154:Mutation; D012270:Ribosomes / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D004917:Erythromycin