Multiple drug therapy for disseminated malignant tumours.
Forty patients with various disseminated malignant tumours were treated with up to six antitumour drugs given for periods not exceeding 24 hours. Complete or partial objective tumour regression was achieved in 20 patients. No regression occurred in the remaining 20. Treatment given in this way seemed to be at least as effective as other multiple drug regimens and had the following advantages: (1) toxicity was reduced to a minimum and no access was needed to sterile rooms or platelet transfusions since severe bone marrow depression did not occur, and (2) the patients spent only a very short time in hospital.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy*; D012075:Remission, Spontaneous; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D003561:Cytarabine; D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate