Electroshock effects on brain protein synthesis: relation to brain seizures and retrograde amnesia.
The effects of electroshock on brain seizure activity and brain protein synthesis were studied in male mice. A significant but short-lasting inhibition of brain protein synthesis and an increase in the amount of free leucine were produced by electroshock at intensities above the brain seizure threshold. Electroshock at intensities below the brain seizure threshold did not affect brain protein synthesis.
D000647:Amnesia / Q000209:etiology*; D000769:Anesthesia, Inhalation; D000818:Animals; D001923:Brain Chemistry; D002490:Central Nervous System / Q000187:drug effects; D004558:Electric Stimulation; D004566:Electrodes; D004597:Electroshock; D005019:Ethyl Ethers / Q000494:pharmacology; D006801:Humans; D007930:Leucine / Q000008:administration & dosage / Q000302:isolation & purification / Q000378:metabolism; D008297:Male; D051379:Mice; D014176:Protein Biosynthesis; D011506:Proteins / Q000032:analysis; D012640:Seizures / Q000150:complications*; D013997:Time Factors
D005019:Ethyl Ethers; D011506:Proteins; D007930:Leucine