Norepinephrine biosynthesis inhibition: effects on memory in mice.
Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated in single-trial passive avoidance in C57BL/6J mice.
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D003864:Depression, Chemical; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D009638:Norepinephrine / Q000096:biosynthesis*; D013859:Thiocarbamates / Q000494:pharmacology*
D002247:Carbon Isotopes; D013859:Thiocarbamates; D004295:Dihydroxyphenylalanine; D006899:Mixed Function Oxygenases; D004298:Dopamine; D009638:Norepinephrine