Methamphetamine-induced insulin release.
Administration of methamphetamine or amphetamine to rats and mice produces a rapid increase in the level of immunoassayable plasma insulin not attributable to hyperglycemia. While in the mouse this release of insulin is followed consistently by a profound hypoglycemia, in the rat this response is variable. Studies in vitro demonstrate that insulin is released by a direct effect of methamphetamine on the pancreas.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010179:Pancreas / Q000187:drug effects; D011863:Radioimmunoassay; D051381:Rats; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D008694:Methamphetamine