title: Aggregations of 35-nanometer particles associated with neuronal cytopathic changes in natural scrapie.
abstract: Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.
mesh_terms: D000818:Animals; D003588:Cytopathogenic Effect, Viral; D003593:Cytoplasm; D007031:Hypothalamus / Q000166:cytology; D008854:Microscopy, Electron; D009474:Neurons / Q000166:cytology*; D012608:Scrapie / Q000473:pathology*; D012756:Sheep