title: Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase.
abstract: The rate of synthesis of delta-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of delta-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for delta-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.
mesh_terms: D000483:Alleles; D000818:Animals; D001947:Breeding; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D006358:Hot Temperature; D006824:Hybridization, Genetic; D006836:Hydro-Lyases / Q000032:analysis / Q000096:biosynthesis*; D007982:Levulinic Acids; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D011489:Protein Denaturation
chemical_list: D007982:Levulinic Acids; D006836:Hydro-Lyases