title: Environmental nitroso compounds: reaction of nitrite with creatine and creatinine.
abstract: Creatine reacts with nitrite under acid conditions to produce first sarcosine and then N-nitrososarcosine, which is a weak carcinogen in the rat. Creatinine reacts with acidified nitrite to produce either creatinine-5-oxime or 1-methylhydantoin-5-oxime, depending on reaction conditions. The toxicity and environmental significance of these compounds is not yet known.
mesh_terms: D002273:Carcinogens / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003401:Creatine; D003404:Creatinine; D006827:Hydantoins / Q000138:chemical synthesis; D009573:Nitrites; D009603:Nitroso Compounds / Q000138:chemical synthesis*; D010091:Oximes / Q000138:chemical synthesis; D012521:Sarcosine / Q000138:chemical synthesis
chemical_list: D002273:Carcinogens; D006827:Hydantoins; D009573:Nitrites; D009603:Nitroso Compounds; D010091:Oximes; D003404:Creatinine; D003401:Creatine; D012521:Sarcosine