A mathematical model of the human menstrual cycle.
A mathematical model for the hormonal interactions of the human menstrual cycle is presented. The feedback effects of estrogen on the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are considered, including a mechanism describing the midcycle LH peak. Computer simulation with this model yields results which are periodic and in good agreement with physiological data.
D003201:Computers; D003338:Corpus Luteum / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D004967:Estrogens; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism; D008433:Mathematics; D008598:Menstruation; D008954:Models, Biological; D006080:Ovarian Follicle / Q000254:growth & development; D010060:Ovulation; D010507:Periodicity; D010902:Pituitary Gland; D011374:Progesterone / Q000097:blood / Q000378:metabolism
D004967:Estrogens; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone