Determination of the renal clearance of inulin in rats: lowered values at low urine flow rates.
The renal clearance of inulin (ClIN) was measured in anaesthetized male rats using a continuous intravenous infusion method.ClIN was independent of urine flow rate provided this was greater than 0.03 ml/minute.At flow rates lower than this, CIIN was reduced and appeared to correlate with the rate of flow.In experiments where a constant kidney function is required. e.g., pharmacokinetic studies, it is advisable to maintain urine, flow rates in the rat above 0.03 ml/minute.
D000818:Animals; D004231:Diuresis; D005919:Glomerular Filtration Rate; D007444:Inulin / Q000378:metabolism* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D014316:Tritium
D014316:Tritium; D007444:Inulin