title: Seventy-five cases of solid tumours treated by a modified quadruple chemotherapy regime.
abstract: Seventy-five cases of malignant solid tumours treated by a quadruple chemotherapy regime are described. These tumours originated in the breast, head and neck, bronchus, genital tract, cutaneous melanoma, soft tissue and gastro-intestinal tract. All 14 patients with breast carcinoma underwent remission and in 6 this was complete. Significant remissions were seen in gastro-intestinal and head and neck malignancies, and also in the soft tissue group. A short response was noted in 6 of 14 cases of bronchial carcinoma. Malignant melanoma, testicular, ovarian and cervical carcinomata failed to respond.In all, 40 of 75 patients underwent objective remission.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy; D001984:Bronchial Neoplasms / Q000188:drug therapy; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy; D006257:Head; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy; D012509:Sarcoma / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate