Effect of 6-hydroxydopamine on electrical self stimulation of the brain.
In rats, after a single intracisternal injection of 6-hydroxydopamine (6-OHDA) electrical self stimulation was reduced by approximately 50%. The concentrations of noradrenaline and dopamine in the brain were reduced by 83%. A second injection of 6-OHDA reduced the concentration of these amines to 7% of control values and virtually eliminated self stimulation.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis; D004558:Electric Stimulation; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D012653:Self Stimulation; D013997:Time Factors
D010627:Phenethylamines; D004298:Dopamine; D009638:Norepinephrine