title: Product of Staphylococcus aureus responsible for the scalded-skin syndrome.
abstract: Certain Staphylococcus aureus strains of phage group 2 produced a protein distinct from the alpha and delta toxins which was capable of causing generalized exfoliation in neonatal mice and presumably is responsible for the scalded-skin syndrome in humans. This protein, named "exfoliatin," was purified and found to have a molecular weight of approximately 24,000. Exfoliatin was acid-labile, rather heat-stabile, and antigenic.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001426:Bacterial Proteins / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001434:Bacteriophage Typing; D002848:Chromatography, DEAE-Cellulose; D004731:Endotoxins / Q000032:analysis / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D006460:Hemolysin Proteins; D051379:Mice; D008970:Molecular Weight; D012871:Skin Diseases / Q000139:chemically induced*; D013210:Staphylococcus / Q000032:analysis* / Q000378:metabolism; D013577:Syndrome
chemical_list: D001426:Bacterial Proteins; D004731:Endotoxins; D006460:Hemolysin Proteins