Snake neurotoxins: effect of disulfide reduction on interaction with electroplax.
Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000997:Antivenins; D001565:Benzoates / Q000494:pharmacology; D001665:Binding Sites; D004220:Disulfides / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004524:Eels; D004557:Electric Organ / Q000187:drug effects* / Q000294:innervation; D009574:Nitro Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D012911:Snakes; D013440:Sulfides; D014688:Venoms / Q000032:analysis / Q000494:pharmacology*
D000997:Antivenins; D001565:Benzoates; D004220:Disulfides; D009574:Nitro Compounds; D013440:Sulfides; D014688:Venoms; D004229:Dithiothreitol