title: Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis.
mesh_terms: D000493:Allopurinol / Q000494:pharmacology* / Q000627:therapeutic use; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors; D002854:Chromatography, Paper; D003864:Depression, Chemical; D004912:Erythrocytes / Q000201:enzymology; D006073:Gout / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007042:Hypoxanthines; D066298:In Vitro Techniques; D007926:Lesch-Nyhan Syndrome / Q000378:metabolism; D008297:Male; D009963:Orotic Acid / Q000378:metabolism / Q000652:urine; D010430:Pentosyltransferases / Q000032:analysis; D011720:Pyrazoles / Q000494:pharmacology / Q000627:therapeutic use; D011743:Pyrimidines / Q000096:biosynthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013147:Spirometry; D013997:Time Factors
chemical_list: D002247:Carbon Isotopes; D007042:Hypoxanthines; D011720:Pyrazoles; D011743:Pyrimidines; D002245:Carbon Dioxide; D009963:Orotic Acid; D000493:Allopurinol; D010430:Pentosyltransferases; D002262:Carboxy-Lyases