Effect of dopamine on pancreatic secretion in the dog.
1. Effects of L-dopa and dopamine on the secretion of pancreatic juice were investigated in preparations of the isolated blood-perfused canine pancreas.2. Dopamine (1-10 mug) given intra-arterially caused a profuse flow of juice.3. The secretory activity of dopamine (3 mug) was approximately equal to that of secretin (0.1 unit).4. L-Dopa (10-100 mug) given by a single intra-arterial injection was ineffective, but infusion at 100 mug/min for 10 min caused a marked increase of secretion after a delay of a few minutes.5. Intravenous administration of either L-dopa (3 mg/kg) or dopamine (10-100 mug/kg) elicited a marked increase of pancreatic secretion, but was definitely less effective than intra-arterial injection.6. Dopamine-induced secretion was not modified by atropine, phentolamine, propranolol, guanethidine or tetrodotoxin.7. It is concluded that dopamine acts directly on the exocrine cells in the pancreas.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012633:Secretin / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors
D012633:Secretin; D013779:Tetrodotoxin; D004295:Dihydroxyphenylalanine; D001285:Atropine; D011433:Propranolol; D004298:Dopamine; D010646:Phentolamine; D006145:Guanethidine