Biliary excretion of barbiturates.
1. Pentobarbitone and phenobarbitone are excreted into the bile of rats.2. The concentration of pentobarbitone and/or its metabolites in the bile is 22-fold higher than in the plasma; the concentration of phenobarbitone and/or its metabolites in bile is 10-fold higher than in the plasma.3. Probenecid decreases the excretion of the barbiturates into the bile.4. Twenty-eight per cent of a 35 mg/kg dose of pentobarbitone and 18% of a 75 mg/kg dose of phenobarbitone is excreted in the bile in 6 hours.5. Most of the pentobarbitone and phenobarbitone excreted into the bile is not in the form of the parent compound but rather as a more polar metabolite or metabolites.
D000818:Animals; D001463:Barbiturates / Q000032:analysis / Q000378:metabolism*; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D002247:Carbon Isotopes; D008099:Liver / Q000032:analysis; D008297:Male; D010424:Pentobarbital / Q000032:analysis / Q000097:blood; D010634:Phenobarbital / Q000032:analysis / Q000097:blood; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
D001463:Barbiturates; D002247:Carbon Isotopes; D010424:Pentobarbital; D011339:Probenecid; D010634:Phenobarbital