Comparative nephrotoxicity of aspirin and phenacetin derivatives.
Both aspirin and phenacetin derivatives were shown to be nephrotoxic when administered to rats as a single intravenous injection. Phenacetin derivatives tended to produce more severe renal damage and to be nephrotoxic in smaller doses than aspirin derivatives. With the exception of a single derivative, the renal lesions were confined to the proximal convoluted tubule, even after administration of compounds which under other conditions have induced renal papillary necrosis.
D000814:Aniline Compounds; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced*; D007681:Kidney Papillary Necrosis / Q000139:chemically induced; D007684:Kidney Tubules / Q000473:pathology; D010615:Phenacetin / Q000633:toxicity*; D010636:Phenols; D051381:Rats; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D010636:Phenols; D010615:Phenacetin; D001241:Aspirin