Target cell destruction in vitro by concanavalin A-stimulated lymphoid cells.
Guinea pig lymphoid cells obtained from lymph nodes and spleens of nonimmune animals are cytotoxic for mouse L-cell fibroblasts on incubation with concanavalin A. This effect is blocked by methyl-alpha-D-mannoside. The results indicate that this effect may be due to the release of a lymphotoxin by the concanavalin A-stimulated lymphocytes.
D000818:Animals; D002478:Cells, Cultured / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006027:Glycosides / Q000494:pharmacology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007739:L Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D037102:Lectins / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D008358:Mannose / Q000494:pharmacology; D051379:Mice; D013997:Time Factors
D006027:Glycosides; D037102:Lectins; D003208:Concanavalin A; D008358:Mannose