Blocking effect of McN-A-343 on cardiac slowing produced by vagal stimulation.
The effect of McN-A-343 was studied by direct administration into the sinus node artery of dogs vagotomized at the mid-cervical level. McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D006339:Heart Rate / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012849:Sinoatrial Node / Q000187:drug effects; D014628:Vagotomy; D014630:Vagus Nerve / Q000187:drug effects*
D002219:Carbamates; D000644:Quaternary Ammonium Compounds; D009538:Nicotine; D000109:Acetylcholine