title: The effect of prolonged pancreatic secretion on blood acid-base balance in the conscious dog.
abstract: Prolonged near maximal pancreatic secretion in conscious dogs has been found to result in a metabolic acidosis. This is mild and is accompanied by respiratory and other forms of compensation. Measurements of blood bicarbonate or base-excess changes cannot be used to estimate pancreatic bicarbonate output. The acidosis caused by pancreatic secretion cannot explain the changes in bicarbonate concentration seen in pancreatic juice during prolonged secretion.
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000209:etiology; D000818:Animals; D001639:Bicarbonates / Q000032:analysis / Q000097:blood / Q000378:metabolism; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D003243:Consciousness; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000032:analysis / Q000378:metabolism*; D012119:Respiration; D012633:Secretin; D012636:Secretory Rate
chemical_list: D001639:Bicarbonates; D012633:Secretin; D002245:Carbon Dioxide