Pharmacokinetics of cyclophosphamide in man.
1. The pharmacokinetics of cyclophosphamide were investigated in cancer patients. The data can be characterized by a two-compartment open model. The half life of the elimination phase of the drug ranged between 3 and 11 hours.2. Extensive tubular reabsorption of the drug resulted in the excretion of only a small percentage of the administered dose. The mean renal clearance was 10.7 ml/minute.3. The calculated fraction of the dose of drug which was metabolized averaged 88%.
D001711:Biotransformation; D002247:Carbon Isotopes; D003520:Cyclophosphamide / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological
D002247:Carbon Isotopes; D003520:Cyclophosphamide