The gastric secretory response to insulin: an 'all-or-none' phenomenon?
Dogs were prepared with Pavlov pouches which could be perfused with saline so as to detect rapidly changes occurring in acid secretion.Dose-response studies were performed by the intravenous injection of insulin (0.06, 0.12, 0.25, 0.5, or 1.0 unit/kg). Both the magnitude of peak response and the duration of response were dose-related and both were related to the magnitude of fall in plasma glucose. These results are not consistent with an ;all-or-none' hypothesis for insulin-stimulated gastric acid secretion, but favour the alternative hypothesis that insulin provides a graded glycopenic stimulus producing a graded secretory response.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D005747:Gastric Fistula; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D007275:Injections, Intravenous; D007328:Insulin / Q000494:pharmacology*; D010477:Perfusion; D012636:Secretory Rate / Q000187:drug effects; D012965:Sodium Chloride; D013268:Stimulation, Chemical
D001786:Blood Glucose; D007328:Insulin; D012965:Sodium Chloride