3 H-noradrenaline-accumulating ability of cholinergic nerve terminals in cat sympathetic ganglia.
1. After incubation of pieces of cat posterior mesenteric ganglion in [(3)H]-noradrenaline solution, the localization of the isotope was assessed by electron-autoradiography.2. Significantly higher concentrations of [(3)H]-noradrenaline were found over acetylcholinesterase-positive axons terminal on ganglion cells than in adjacent background areas.3. [(3)H]-Noradrenaline was not accumulated by ganglion cells under these circumstances.4. The significance of these findings in relation to previous physiological and pharmacological investigation is discussed.
D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000378:metabolism; D001345:Autoradiography; D002415:Cats; D005725:Ganglia, Autonomic / Q000378:metabolism*; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000201:enzymology / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D000110:Acetylcholinesterase; D009638:Norepinephrine