Effect of  -3-thienylalanine on antibody synthesis. V. Immunosuppression in mice by short diet and drug treatments.
The analogue of phenylalanine, beta-3-thienylalanine, depresses severely the primary and secondary immune response to sheep erythrocytes in mice when administered for a few days immediately before and after each injection of antigen. For this immunosuppression to occur, animals must be maintained on a phenylalanine-free diet during the times of drug injection since dietary phenylalanine will restore anamnestic response. With these experimental conditions, the number of direct and indirect plaque-forming cells is greatly reduced during immune responses. The finding that marked immunosuppression can be obtained with a very short drug and diet treatment points to a potential usefullness of the analogue as a powerful immunosuppressant.
D000409:Alanine / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004032:Diet; D004912:Erythrocytes / Q000276:immunology; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010649:Phenylalanine / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013876:Thiophenes / Q000494:pharmacology; D013997:Time Factors
D007166:Immunosuppressive Agents; D013876:Thiophenes; D010649:Phenylalanine; D000409:Alanine