title: Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin.
abstract: Two methylated derivatives of arginine were isolated from the encephalitogenic protein of myelin from the central nervous system. Evidence is presented for the proposed structures, omega-NN'-dimethylarginine and omega-N-monomethylarginine. In the encephalitogenic protein from human brain the proportion 1:6:10 for arginine:monomethylarginine:dimethylarginine residues was found to occur at position 107. Possible roles for the methylated arginine in conformational changes and altered ion-exchange behaviour are discussed.
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001120:Arginine / Q000302:isolation & purification*; D001923:Brain Chemistry; D002417:Cattle; D002845:Chromatography; D004586:Electrophoresis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D006801:Humans; D006868:Hydrolysis; D008745:Methylation; D009186:Myelin Sheath / Q000032:analysis*; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010455:Peptides / Q000032:analysis; D013116:Spinal Cord / Q000032:analysis
chemical_list: D000596:Amino Acids; D009419:Nerve Tissue Proteins; D010455:Peptides; D001120:Arginine