title: Snake neurotoxins: effect of disulfide reduction on interaction with electroplax.
abstract: Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000997:Antivenins; D001565:Benzoates / Q000494:pharmacology; D001665:Binding Sites; D004220:Disulfides / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004524:Eels; D004557:Electric Organ / Q000187:drug effects* / Q000294:innervation; D009574:Nitro Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D012911:Snakes; D013440:Sulfides; D014688:Venoms / Q000032:analysis / Q000494:pharmacology*
chemical_list: D000997:Antivenins; D001565:Benzoates; D004220:Disulfides; D009574:Nitro Compounds; D013440:Sulfides; D014688:Venoms; D004229:Dithiothreitol