Changes of the smooth endoplasmic reticulum induced by rifampicin in human and guinea-pig hepatocytes.
Rifampicin induces a proliferation of the smooth endoplasmic reticulum in guinea-pig and human hepatocytes. This may support the hypothesis of enhancement of drug-metabolizing enzymes induced by the drug. However, the pattern of proliferation is not similar in man and in guinea-pig hepatocytes. Some caution is needed in the study of enzyme induction in man and in extrapolations from animal to human data.
D000818:Animals; D001711:Biotransformation; D003593:Cytoplasm; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000201:enzymology; D004790:Enzyme Induction; D006003:Glycogen; D006168:Guinea Pigs; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000187:drug effects; D008854:Microscopy, Electron; D008930:Mitochondria, Liver; D012293:Rifampin / Q000494:pharmacology*
D006003:Glycogen; D012293:Rifampin