The analysis of genetically determined hair defects.
A classification of genetically determined hair defects based on pathophysiologic considerations is presented to facilitate research in this area. The categories in the classification are: 1) hair with periodic defects in structure; 2) complete or partial failure of hair development manifested by sparseness; 3) hairs with structural protein abnormalities and 4) defective hairs associated with metabolic defects. The methodologies for the study of hair are discussed including a new technic to directly measure Young's modulus of elasticity. A new autosomally dominantly inherited disorder with sparse hair and milia is presented.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002648:Child; D000013:Congenital Abnormalities / Q000145:classification; D004586:Electrophoresis; D006197:Hair / Q000002:abnormalities* / Q000378:metabolism; D006801:Humans; D008859:Microscopy, Polarization; D010375:Pedigree; D051381:Rats; D012756:Sheep; D013314:Stress, Mechanical; D013455:Sulfur / Q000378:metabolism; D014465:Ultrasonics; D014961:X-Ray Diffraction
D000596:Amino Acids; D013455:Sulfur