Antifungal activity of substituted nitrobenzenes and anilines.
Series of 1,3-dihalogeno-5-nitrobenzenes, 3- and 3,5-halogenoanilines, and 2,6-dihalogeno-4-nitroanilines were tested for fungitoxicity against Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes in shaken culture by using Sabouraud dextrose broth enriched with yeast extract as the test medium. 1,3-Dichloro-5-nitrobenzene, 1,3-dibromo-5-nitrobenzene, 3-iodoaniline, 3,5-dichloroaniline, and 3,5-dibromoaniline were found to possess sufficient activity, compared with 8-quinolinol, to warrant further study.
D000814:Aniline Compounds / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D003470:Culture Media; D005947:Glucose; D006219:Halogens / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000187:drug effects*; D009574:Nitro Compounds / Q000494:pharmacology; D009578:Nitrobenzenes / Q000494:pharmacology*; D012440:Saccharomyces; D013045:Species Specificity; D013170:Spores / Q000187:drug effects*; D013172:Spores, Fungal / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects*
D000814:Aniline Compounds; D000935:Antifungal Agents; D003470:Culture Media; D006219:Halogens; D009574:Nitro Compounds; D009578:Nitrobenzenes; D005947:Glucose