Irreversible enzyme inhibitors. 185. Active-site-directed irreversible inhibitors of guanine deaminase derived from 9-phenylguanine bearing a terminal sulfonyl fluoride. 2.
D000619:Aminohydrolases / Q000037:antagonists & inhibitors*; D000813:Anilides / Q000138:chemical synthesis; D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis; D002279:Carcinoma 256, Walker / Q000201:enzymology*; D002713:Chlorine; D004987:Ethers / Q000138:chemical synthesis; D005461:Fluorine; D006147:Guanine / Q000138:chemical synthesis*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis*; D014508:Urea / Q000138:chemical synthesis
D000813:Anilides; D001555:Benzene Derivatives; D004987:Ethers; D013451:Sulfonic Acids; D005461:Fluorine; D002713:Chlorine; D006147:Guanine; D014508:Urea; D000619:Aminohydrolases