Effects of various drugs on hemolytic activity of Streptococcus zymogenes.
Drugs known to interrupt the chain of protein synthesis (streptomycin, chloramphenicol, ethidium bromide) appeared to affect production of the group D lysin by Streptococcus zymogenes by inhibiting growth. Drugs which block cell wall synthesis (vancomycin, bacitracin, d-cycloserine, and phosphonomycin) inhibited lytic activity by a mechanism independent of growth. Bacitracin appeared not to have a major effect on lysin production but elicited the production of an inhibitor of lytic activity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001414:Bacitracin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D003523:Cycloserine / Q000494:pharmacology; D004912:Erythrocytes / Q000276:immunology; D005827:Genetics, Microbial; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006461:Hemolysis; D009154:Mutation; D010617:Phenanthridines / Q000494:pharmacology*; D011817:Rabbits; D013291:Streptococcus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D013307:Streptomycin / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D006460:Hemolysin Proteins; D010617:Phenanthridines; D001414:Bacitracin; D002701:Chloramphenicol; D014640:Vancomycin; D003523:Cycloserine; D013307:Streptomycin