Genetic approaches to the nosology of nervous system defects.
The significance of genetics to the nosology of nervous system diseases has been shown in spastic paraplegias and spinocerebellar ataxias. At least about 60 different genetic types have been recognized to date. In most diseases, the genetic exploration and discrimination of types has been possible only by clinical, pathologic and simple genetic criteria like transmission. Further differentiation of genetic entities will be done especially through biochemical investigation.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001260:Ataxia Telangiectasia / Q000453:epidemiology; D002524:Cerebellar Ataxia / Q000145:classification / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D003241:Consanguinity; D048909:Diabetes Complications; D005260:Female; D005621:Friedreich Ataxia / Q000150:complications; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000145:classification / Q000235:genetics*; D010375:Pedigree; D012730:Sex Chromosomes