Effect of L-dopa on speech in Parkinsonism. An EMG study of labial articulatory function.
The articulatory function of the labial musculature has been investigated electromyographically before and after treatment with l-dopa in patients with Parkinsonism who had dysarthria. Before medication the EMG traces generally showed a constant, abnormally increased, tonic activity, together with disturbed reciprocal innervation, which impaired the articulatory activity. After medication the tonic hyperactivity was reduced and the reciprocal innervation re-established. This normalization of the EMG articulatory pattern was paralleled by an improvement of the dysarthria.
D004295:Dihydroxyphenylalanine / Q000627:therapeutic use*; D004576:Electromyography; D006801:Humans; D008046:Lip / Q000294:innervation / Q000503:physiopathology*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology; D013060:Speech / Q000187:drug effects*
D004295:Dihydroxyphenylalanine