Pierre Robin syndrome occurring in two related sibships.
Four children affected with Pierre Robin syndrome occurring in two related sibships are described. The fathers of these sibships are second cousins and both of them have deceased sibs with histories of respiratory or feeding difficulties or both, or cleft palate. Mode of inheritance suggested by these findings is autosomal dominant with variable expression and incomplete penetrance.
D000328:Adult; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008334:Mandible; D010375:Pedigree; D010855:Pierre Robin Syndrome / Q000235:genetics*