X-linked cleft palate.
Cleft lip with or without cleft palate is twice as frequent among Indians of British Columbia as among non-Indians, although the reverse is the case whenever we consider isolated cleft palate. A family is described with 12 affected males. Close examination of this family revealed that the most likely explanation for the cleft palate was an X-linked recessive gene. It is concluded that isolated cleft palate among the Indians of British Columbia is an extremely rare anomaly.
D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D002972:Cleft Palate / Q000235:genetics*; D005808:Genes, Recessive; D006801:Humans; D007198:Indians, North American; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D012730:Sex Chromosomes; D012744:Sex Ratio; D014609:Uvula / Q000002:abnormalities