Effect of antibiotics on staphylococcal hemolysin production.
Thirty-seven per cent of 126 strains of Staphylococcus aureus, when tested on sheep blood-agar with sensitivity discs containing cephalothin, carbenicillin, oxacillin, penicillin, and cycloserine, produced rings of beta-hemolysis surrounding zones of inhibition of bacterial growth. Each strain capable of producing a ring of beta-hemolysis did so with at least two of the mentioned antibiotics. None of the other 15 antibiotics tested was associated with a ring of beta-hemolysis surrounding any of the zones of inhibition. It appears, therefore, that the beta-hemolysis observed was produced by certain strains of S. aureus only in association with certain antibiotics.
D000362:Agar; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004912:Erythrocytes / Q000276:immunology; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006461:Hemolysis; D006736:Horses; D006801:Humans; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D006460:Hemolysin Proteins; D000362:Agar