Pteridines produced by Methylococcus capsulatus. Isolation and identification of a neopterin 2':3'-phosphate.
Three pteridines have been isolated from the methane- or methanol-oxidizing bacterium Methylococcus capsulatus. Two of these are known compounds, 2-amino-6-carboxy-4-hydroxypteridine and 2-amino-4-hydroxy-6-methylpteridine. The third is shown by degradative and synthetic experiments to be l-threo-neopterin 2':3'-phosphate. Labelling experiments show that both the pteridine moiety and phosphate residue are derived from a single GTP molecule. The possible metabolic significance of these compounds in methanol oxidation is discussed.
D001419:Bacteria / Q000378:metabolism*; D002247:Carbon Isotopes; D002498:Centrifugation; D002854:Chromatography, Paper; D004590:Electrophoresis, Paper; D006160:Guanosine Triphosphate / Q000378:metabolism; D006868:Hydrolysis; D000432:Methanol / Q000378:metabolism; D010710:Phosphates / Q000302:isolation & purification; D011621:Pteridines / Q000096:biosynthesis / Q000302:isolation & purification*
D002247:Carbon Isotopes; D010710:Phosphates; D011621:Pteridines; D006160:Guanosine Triphosphate; D000432:Methanol