In vitro sensitivity of Torulopsis glabrata to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097).
Thirty-five strains of Torulopsis glabrata were tested by a tube dilution method for their susceptibility to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097). Amphotericin B was the most active in vitro, inhibiting all strains at a concentration of 1 mug/ml and killing all strains at 2 mug/ml. 5-Fluorocytosine inhibited over 80% of strains at 0.24 mug/ml, but three strains required >/=7.8 mug/ml for killing. A concentration of 2 mug of clotrimazole per ml inhibited less than 50% of strains, and 8 mug/ml killed only 10% of strains. Most strains of T. glabrata were killed by therapeutically achievable concentrations of amphotericin B and 5-fluorocytosine, but not clotrimazole.
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000494:pharmacology; D002177:Candidiasis / Q000382:microbiology; D003596:Cytosine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005461:Fluorine / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects* / Q000302:isolation & purification; D013045:Species Specificity
D000935:Antifungal Agents; D001555:Benzene Derivatives; D007093:Imidazoles; D005461:Fluorine; D000666:Amphotericin B; D003596:Cytosine