Cherubism: a family study to delineate gene action on mandibular growth and development.
A family with autosomal dominant cherubism is described. Two brothers in a sibship of five who have each had two affected sons show none of typical clinical features of the disease. Their parents also appear unaffected. Roentgenographic study of the skulls of the grandfather and the two fathers of affecteds revealed previously unreported mandibular bone changes compatible with cherubism at an earlier age.
D000293:Adolescent; D002508:Cephalometry; D002636:Cherubism / Q000000981:diagnostic imaging / Q000235:genetics*; D002648:Child; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D008334:Mandible / Q000254:growth & development; D010375:Pedigree; D011859:Radiography; D012886:Skull / Q000000981:diagnostic imaging