The toxicity of 125 IUdR in cultured mouse BP8 tumour cells.
The toxicity of the low-energy electrons from (125)I in labelled IUdR was assayed by labelling the DNA of BP8 mouse tumour cells with the nucleoside and studying their subsequent growth in culture. Toxicity was observed in cells grown in medium containing more than 0·01 μCi/ml. The amount of label incorporated into cells showing deleterious effects is compared with that reported by others.
D000818:Animals; D002460:Cell Line / Q000378:metabolism / Q000528:radiation effects*; D002467:Cell Nucleus; D002470:Cell Survival / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D007065:Idoxuridine / Q000378:metabolism*; D007456:Iodine Isotopes; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D009374:Neoplasms, Experimental; D011830:Radiation Effects
D004273:DNA, Neoplasm; D007456:Iodine Isotopes; D007065:Idoxuridine