Irreversible enzyme inhibitors. LXXXVI. Hydrophobic bonding to dihydrofolic reductase. 8. Substituted-1-aryl-4,6-diamino-1,2-dihydro-2,2-dimethyl-s-triazines.
D000630:Aminopterin / Q000494:pharmacology; D002625:Chemistry, Organic; D004798:Enzymes; D005492:Folic Acid / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D055601:Organic Chemistry Phenomena; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
D004798:Enzymes; D014227:Triazines; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D000630:Aminopterin