Irreversible enzyme inhibitors. CXXVII. p-(2,6-diamino-1,2-dihydro--2,2-dimethyl-s-triazin-1-yl)phenylpropionylsulfanilyl fluoride, an active-site-directed irreversible inhibitor of dihydrofolic reductase. 3. Effects of modification of the propionamide bridge on isozyme specificity.
D000577:Amides; D000818:Animals; D001665:Binding Sites; D002279:Carcinoma 256, Walker / Q000201:enzymology; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D007942:Leukemia, Experimental / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D051381:Rats; D014227:Triazines
D000577:Amides; D005493:Folic Acid Antagonists; D007527:Isoenzymes; D014227:Triazines