[Formate activation and de novo synthesis of purine nucleotides in leukemia cells and its therapeutic modification by 6-mercaptopurine].
D001853:Bone Marrow / Q000201:enzymology / Q000378:metabolism; D001854:Bone Marrow Cells; D002247:Carbon Isotopes; D002854:Chromatography, Paper; D005492:Folic Acid / Q000378:metabolism*; D005561:Formates / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D007962:Leukocytes / Q000201:enzymology / Q000378:metabolism; D008025:Ligases / Q000378:metabolism*; D015122:Mercaptopurine / Q000627:therapeutic use*; D009705:Nucleosides / Q000096:biosynthesis; D009711:Nucleotides / Q000096:biosynthesis*; D010088:Oxidoreductases / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D002247:Carbon Isotopes; D005561:Formates; D009705:Nucleosides; D009711:Nucleotides; D011687:Purines; D005492:Folic Acid; D015122:Mercaptopurine; D010088:Oxidoreductases; D013762:Tetrahydrofolate Dehydrogenase; D008025:Ligases
Formiat-Aktivierung und de novo-Synthese von Purinnucleotiden in Leukämiezellen und ihre therapeutische Beeinflussung durch 6-Mercaptopurin.