Irreversible enzyme inhibitors. CXX. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 6-substituted 2,4-diamino-5-phenylpyrimidines with tissue specificity.
D000818:Animals; D001665:Binding Sites; D002279:Carcinoma 256, Walker / Q000201:enzymology; D005459:Fluorides; D005493:Folic Acid Antagonists; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis; D051381:Rats; D013451:Sulfonic Acids
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013451:Sulfonic Acids; D005459:Fluorides