Model for constraint and control in biochemical networks.
A model is proposed for biochemical networks which takes into account substrate and modifier effects on enzyme activity and the different time scales on which the relevant processes occur. Sources of global constraint that can be utilized in metabolic regulation are indicated, and the relation of the model to the experiments of Kauffman on switching networks is analyzed. The biological significance of the model and possible systems in which it might be tested are discussed.
D003491:Cybernetics; D004798:Enzymes / Q000378:metabolism; D007700:Kinetics; D008660:Metabolism; D008954:Models, Biological; D008967:Molecular Biology
D004798:Enzymes