Age response to x-radiation of murine lymphoma cells synchronized in vivo.
Cells of a transplantable murine lymphoma line were partially synchronized in vivo by administration of a single dose of 0.5 mg of hydroxyurea per lymphoma-bearing mouse. At various times after administration of hydroxyurea, the femurs of the lymphomatous mice were X-irradiated, and the number of lymphoma colony-forming units per femur were then assayed by the spleencolony technique. A well-defined age response to irradiation of the lymphoma cells in vivo, similar to that of HeLa cells in vitro, was observed.
D000375:Aging; D000818:Animals; D001681:Biological Assay; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells; D006367:HeLa Cells / Q000528:radiation effects; D006918:Hydroxyurea / Q000494:pharmacology; D008223:Lymphoma / Q000532:radiotherapy*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000532:radiotherapy*; D011831:Radiation Genetics; D013154:Spleen
D006918:Hydroxyurea