Remission induction with cytosine arabinoside and L-asparaginase in acute lymphoblastic leukaemia.
Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete remission of their disease. This combination of drugs is sufficiently effective to suggest that further trial is needed. It is possible that the combination has a synergistic effect.
D000208:Acute Disease; D001215:Asparaginase / Q000008:administration & dosage*; D001855:Bone Marrow Diseases / Q000188:drug therapy; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D003561:Cytarabine / Q000008:administration & dosage*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D007958:Leukocyte Count; D008297:Male
D003561:Cytarabine; D001215:Asparaginase