Microcytotoxicity test: detection in sarcoma patients of antibody cytotoxic to human sarcoma cells.
A microcytotoxicity test has been used to detect a factor cytotoxic for human sarcoma cells; the factor was found in serums from 70 percent of sarcoma patients, 58 percent of their family members, and 8 percent of serums from normal blood donors. This cytotoxin is an antibody against a common cell surface sarcoma antigen since it is specific for sarcoma cells, is complement dependent, and is extractable with the globulin fraction of serum.
D000906:Antibodies / Q000032:analysis* / Q000302:isolation & purification; D000918:Antibody Specificity; D002460:Cell Line; D046508:Culture Techniques; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D008080:Liposarcoma / Q000276:immunology; D012516:Osteosarcoma / Q000276:immunology; D012509:Sarcoma / Q000235:genetics / Q000276:immunology*
D000906:Antibodies