Alteration of Methotrexate by leukemic cells: loss of affinity for an anion exchange resin.
D000328:Adult; D006651:Histocytochemistry; D006801:Humans; D007475:Ion Exchange Resins; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy; D007951:Leukemia, Myeloid / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D007962:Leukocytes / Q000201:enzymology*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood; D008727:Methotrexate / Q000378:metabolism* / Q000627:therapeutic use; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
D007475:Ion Exchange Resins; D014316:Tritium; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate