Large-scale digitoxin intoxication.
Because of an error in the manufacture of digoxin tablets a large number of patients took tablets that contained 0.20 mg. of digitoxin and 0.05 mg. of digoxin instead of the prescribed 0.25 mg. of digoxin. The symptoms are described of 179 patients who took these tablets and suffered from digitalis intoxication. Of these patients, 125 had taken the faultily composed tablets for more than three weeks. In 48 patients 105 separate disturbances in rhythm or in atrioventricular conduction were observed on the electrocardiogram. Extreme fatigue and serious eye conditions were observed in 95% of the patients. Twelve patients had a transient psychosis. Extensive ophthalmological observations indicated that the visual complaints were most probably caused by a transient retrobulbar neuritis.
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003863:Depression / Q000139:chemically induced; D004074:Digitoxin / Q000506:poisoning*; D005221:Fatigue / Q000139:chemically induced; D001068:Feeding and Eating Disorders / Q000139:chemically induced; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006327:Heart Block / Q000139:chemically induced; D006801:Humans; D008297:Male; D008508:Medication Errors; D009135:Muscular Diseases / Q000139:chemically induced; D009325:Nausea / Q000139:chemically induced; D013610:Tachycardia / Q000139:chemically induced; D014786:Vision Disorders / Q000139:chemically induced
D004074:Digitoxin