A factor promoting the initiation of globin synthesis in a rabbit reticulocyte cell-free system.
The synthesis of globin has been studied in a reticulocyte cell-free system in which the initiation of polypeptide chain synthesis can proceed for as long as ten minutes of incubation. With this system, we have found evidence for a soluble factor in the reticulocyte that stimulates protein synthesis and appears to act by promoting initiation.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D002474:Cell-Free System; D002499:Centrifugation, Density Gradient; D005914:Globins / Q000096:biosynthesis; D006454:Hemoglobins / Q000096:biosynthesis*; D008239:Lysine / Q000378:metabolism; D008722:Methods; D010452:Peptide Biosynthesis; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism*
D000596:Amino Acids; D001798:Blood Proteins; D002247:Carbon Isotopes; D006454:Hemoglobins; D005914:Globins; D008239:Lysine