Aurintricarboxylic acid: inhibitor of initiation of protein synthesis.
Aurintricarboxylic acid prevents the attachment of bacteriophage messenger RNA to ribosomes. As a consequence, initiation of protein synthesis in cell-free extracts prepared from Escherichia coli or rabbit reticulocytes is inhibited at concentrations of dye that do not prevent chain extension. Its properties can be distinguished from other agents that inhibit protein synthesis, including sodium fluoride, cycloheximide, and pactamycin.
D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis; D002247:Carbon Isotopes; D002474:Cell-Free System; D002499:Centrifugation, Density Gradient; D002701:Chloramphenicol / Q000494:pharmacology; D003090:Coliphages / Q000378:metabolism; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003864:Depression, Chemical; D004589:Electrophoresis, Disc; D005914:Globins / Q000096:biosynthesis; D006639:Histidine / Q000378:metabolism; D007930:Leucine / Q000378:metabolism; D014176:Protein Biosynthesis; D011691:Puromycin / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D012270:Ribosomes / Q000032:analysis / Q000378:metabolism; D013307:Streptomycin / Q000494:pharmacology; D014316:Tritium; D014633:Valine / Q000378:metabolism; D014764:Viral Proteins / Q000096:biosynthesis
D001426:Bacterial Proteins; D002247:Carbon Isotopes; D003509:Cyclohexanecarboxylic Acids; D012333:RNA, Messenger; D014764:Viral Proteins; D014316:Tritium; D011691:Puromycin; D006639:Histidine; D002701:Chloramphenicol; D005914:Globins; D007930:Leucine; D014633:Valine; D013307:Streptomycin