Hyperpyrexia and antipyresis owing to sodium acetylsalicylate in intact and decapitate cats.
Sodium acetylsalicylate (100 mg/kg) intravenously injected into anaesthetized intact or decapitate cats caused an increase in body temperature. At a dosage of 30 mg per kilogram it caused a lowering of body temperature in the intact preparations, but again an increase in decapitate preparations. At a dosage of 10 mg per kilogram, no significant temperature change occurred in either type of preparation. Aspirin (in the form of sodium acetylsalicylate) is a systemic pyrogen and a centrally acting antipyretic. When it occurs, aspirin antipyresis must take place in the face of systemic pyrogenesis. Notable is the fact that aspirin (30 mg/kg) in the intact preparation lowers body temperature not only from fever levels, but also from normal and subnormal levels.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects*; D002415:Cats; D007031:Hypothalamus / Q000502:physiology; D011749:Pyrogens / Q000494:pharmacology
D011749:Pyrogens; D001241:Aspirin