Sympathetic nerve cell destruction in newborn mammals by 6-hydroxydopamine.
A selective and permanent destruction of sympathetic ganglia was achieved by injecting 6-hydroxydopamine in newborn animals. A lifelong chemical sympathectomy may thus be obtained. The process of cell damage and destruction is substantially different from that produced with an antiserum to a specific nerve growth factor.
D000818:Animals; D000831:Animals, Newborn; D002395:Catecholamines / Q000494:pharmacology*; D004298:Dopamine; D005725:Ganglia, Autonomic / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008854:Microscopy, Electron; D009414:Nerve Growth Factors / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*
D002395:Catecholamines; D009414:Nerve Growth Factors; D010627:Phenethylamines; D004298:Dopamine