Selective destruction of adrenal cortex by pulse doses of derivatives of 12-methylbenz(a)anthracene.
Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively. The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.
D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000008:administration & dosage / Q000494:pharmacology*; D004655:Emulsions; D006470:Hemorrhage / Q000139:chemically induced; D007275:Injections, Intravenous; D051381:Rats
D001551:Benz(a)Anthracenes; D004655:Emulsions