Organic anion-binding protein in rat liver: drug induction and its physiologic consequence.
The administration of phenobarbital to rats enhanced hepatic uptake of an organic anion, bromsulphalein, in vivo and simultaneously increased the amount of Y, a hepatic cytoplasmic organic anion-binding protein. This study supports the postulate that Y is a major determinant in the selective hepatic uptake of certain organic anions from plasma. Induction of Y may contribute to the enhanced hepatic uptake and metabolism of various organic anions (drugs, hormones, etc.) produced by phenobarbital and other agents.
D000818:Animals; D002850:Chromatography, Gel; D004586:Electrophoresis; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism
D013448:Sulfobromophthalein; D010634:Phenobarbital