Studies in a patient with acute leukaemia after lysergide treatment.
The second case of acute leukaemia developing after administration of lysergide is reported. The unusual bone-marrow chromosome pattern and the presence of large cells containing multiple micronucleoli suggest that this association may be causal.
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D001856:Bone Marrow Examination; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D006801:Humans; D007945:Leukemia, Lymphoid / Q000139:chemically induced* / Q000188:drug therapy; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D008238:Lysergic Acid Diethylamide; D011239:Prednisolone