A proposed common allosteric mechanism for active transport, muscle contraction, and ribosomal translocation.
It is suggested that active transport, muscle contraction, and ribosomal translocation may all make use of a common allosteric mechanism in which ATP or GTP serves as both the effector and substrate and in which a conformational change in a protein (enzyme) moves or exerts a force on a second ligand. The enzymatic splitting of ATP or GTP provides the driving force for the process and allows repetition of the steady-state cycle.
D000255:Adenosine Triphosphate; D001665:Binding Sites; D001693:Biological Transport, Active; D006150:Guanine Nucleotides; D046911:Macromolecular Substances; D008954:Models, Biological; D008956:Models, Chemical; D009119:Muscle Contraction; D012270:Ribosomes / Q000502:physiology*
D006150:Guanine Nucleotides; D046911:Macromolecular Substances; D000255:Adenosine Triphosphate