Mechanism of proflavin mutagenesis.
The mutagenic action of proflavin on bacteriophage T4 is greater in the presence of defective T4 ligase than in the presence of normal T4 ligase. This suggests that the persistence of single-strand breaks in DNA enhances proflavin mutagenesis.
D003090:Coliphages / Q000187:drug effects*; D004279:DNA, Viral / Q000494:pharmacology; D005415:Flavins / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*
D004279:DNA, Viral; D005415:Flavins; D009153:Mutagens