Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man.
A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the "spontaneous" osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D010759:Phosphorus Isotopes; D011145:Polyvinyls; D011859:Radiography; D051381:Rats; D012513:Sarcoma, Experimental
D010759:Phosphorus Isotopes; D011145:Polyvinyls