Neuronal tumor cells with excitable membranes grown in vitro.
Mouse neuroblastoma cells grown in vitro are capable of generating action potentials in response to electrical stimulation. A wide spectrum of responses was observed with different cells ranging from passive responses to action potentials. A hypothesis is proposed concerning the acquisition of electrical excitability as neuroblasts mature into neurons.
D000200:Action Potentials; D000818:Animals; D002462:Cell Membrane / Q000503:physiopathology; D046508:Culture Techniques; D008564:Membrane Potentials; D051379:Mice; D009374:Neoplasms, Experimental; D009447:Neuroblastoma / Q000503:physiopathology*; D009474:Neurons / Q000503:physiopathology*