Absence of a natural inhibitor of the tRNA methylases from fetal and tumor tissues.
The inhibitor of tRNA methylases of normal adult tissues has been resolved into two fractions, a high molecular weight protein and a low molecular weight (<700) component. The high molecular weight component is absent from embryonic and tumor tissues, both of which are known to possess high tRNA methylase capacity.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D002498:Centrifugation; D002848:Chromatography, DEAE-Cellulose