A genetic marker in the variable region of light chains of mouse immunoglobulins.
A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of (14)C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001345:Autoradiography; D002247:Carbon Isotopes; D002499:Centrifugation, Density Gradient; D004586:Electrophoresis; D014644:Genetic Variation; D007120:Immunochemistry; D007125:Immunogenetics; D007074:Immunoglobulin G; D007136:Immunoglobulins; D007178:Inbreeding; D051379:Mice; D010455:Peptides / Q000032:analysis
D000596:Amino Acids; D002247:Carbon Isotopes; D007074:Immunoglobulin G; D007136:Immunoglobulins; D010455:Peptides