Na plus-facilitated reactions of neutral amino acids with a cationic amino acid transport system.
The predominant basis for transport interactions between neutral and cationic amino acids in the Ehrlich ascites-tumor cell and the rabbit reticulocyte has been identified as a reaction of the neutral amino acid plus Na(+) with the cationic amino acid transport system. This reaction is revealed both by a Na(+)-dependent transport inhibition by the neutral amino acid, and by mutual flux accelerations whereby the neutral amino acid and Na(+) exchange for the cationic amino acid.
D000596:Amino Acids; D000818:Animals; D001692:Biological Transport; D002247:Carbon Isotopes; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D046508:Culture Techniques; D006863:Hydrogen-Ion Concentration; D012156:Reticulocytes / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology*
D000596:Amino Acids; D002247:Carbon Isotopes; D012964:Sodium