Complex mitochondrial DNA in leukemic and normal human myeloid cells.
Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.
D002066:Busulfan / Q000494:pharmacology; D004247:DNA; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D007955:Leukemoid Reaction / Q000097:blood; D007962:Leukocytes; D015122:Mercaptopurine / Q000494:pharmacology; D008722:Methods; D008727:Methotrexate / Q000494:pharmacology; D008854:Microscopy, Electron; D008928:Mitochondria; D055728:Primary Myelofibrosis / Q000097:blood
D004247:DNA; D015122:Mercaptopurine; D002066:Busulfan; D008727:Methotrexate