5-bromodeoxyuridine-induced differentiation of a neuroblastoma.
5-Bromodeoxyuridine induces the differentiation of mouse neuroblastoma C1300 to cells that morphologically resemble mature neurons. The induced differentiation can take place in the absence of DNA synthesis. This suggests that the halogenated pyrimidine need not be incorporated into DNA to alter the phenotype of the cell.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002247:Carbon Isotopes; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003078:Colchicine / Q000494:pharmacology; D046508:Culture Techniques; D003513:Cycloheximide / Q000494:pharmacology; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D003609:Dactinomycin / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology; D009447:Neuroblastoma; D009474:Neurons; D010641:Phenotype; D011691:Puromycin / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D002247:Carbon Isotopes; D008937:Mitomycins; D003561:Cytarabine; D014316:Tritium; D003609:Dactinomycin; D011691:Puromycin; D004247:DNA; D003513:Cycloheximide; D001973:Bromodeoxyuridine; D007930:Leucine; D003078:Colchicine; D013936:Thymidine