Irrevesible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal sulfonyl fluoride.
D000818:Animals; D001665:Binding Sites; D005459:Fluorides / Q000138:chemical synthesis / Q000494:pharmacology; D005493:Folic Acid Antagonists; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology
D005493:Folic Acid Antagonists; D011743:Pyrimidines; D013450:Sulfones; D005459:Fluorides