Induction of melanin synthesis in albino mouse skin by DNA from pigmented mice.
Skin cells from albino mouse embryos have been shown to synthesize melanin after exposure to a nucleoprotein fraction of cells from pigmented mice. Although transformed clones were not found in any of 37 control experiments, at least 15 transformations took place in 10 of a series of 49 experiments using undegraded DNA. The active component in the transforming material appears to be DNA because DNase-treated preparations did not induce melanin synthesis.
D000417:Albinism / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002999:Clone Cells / Q000378:metabolism*; D004247:DNA / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis*; D051379:Mice; D008854:Microscopy, Electron; D010858:Pigmentation; D012867:Skin / Q000378:metabolism; D014170:Transformation, Genetic
D008543:Melanins; D004247:DNA