Identification of a bacterial growth inhibitors from HeLa cells: a ketoaldehyde.
The growth-inhibiting factor found earlier in human cell cultures appeared to be a ketoaldehyde. An infrared spectral study of 2,4-dinitrophenylhydrazine derivatives suggested that the ketoaldehyde was 4-hydroxy-2-ketobutyraldehyde. The compound, when synthesized, gave the same DNPH derivatives as the natural substance.
D000447:Aldehydes / Q000138:chemical synthesis / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D002850:Chromatography, Gel; D006367:HeLa Cells; D006801:Humans; D006851:Hydrochloric Acid; D007659:Ketones / Q000138:chemical synthesis / Q000302:isolation & purification; D010659:Phenylhydrazines
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D007659:Ketones; D010659:Phenylhydrazines; D006851:Hydrochloric Acid