Linkage between the poly-L-lysine gene and the locus controlling the major histocompatibility antigens in strain 2 guinea pigs.
The data presented demonstrate linkage between the major histocompatibility locus of inbred strain 2 guinea pigs and a "specific immune response gene," the PLL gene, which controls responsiveness to poly-L-lysine and hapten conjugates of this polypeptide in these animals. This finding extends to another species and to a different immune system the linkage observed in mice between the H(2) locus and specific immune response genes at the Ir-1 locus. The general significance of the linkage of specific immune response genes to histocompatibility loci is discussed.
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis; D002417:Cattle; D002859:Chromium Isotopes; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D005809:Genes, Regulator; D006168:Guinea Pigs; D006648:Histocompatibility; D007108:Immune Tolerance; D007962:Leukocytes / Q000276:immunology; D008239:Lysine; D008297:Male; D011108:Polymers; D013045:Species Specificity; D014316:Tritium
D000941:Antigens; D002859:Chromium Isotopes; D011108:Polymers; D014316:Tritium; D008239:Lysine