Implications of TL phenotype changes in an H-2-loss variant of a transplanted H-2b-H-2a leukemia.
An H-2-loss variant line, lacking H-2(a) antigens, was obtained from an H-2(b)/H-2(a) (C57BL x A)F(1) transplanted leukemia by immunoselection. The TL phenotype of the unselected line was TL.1,2,3,4 and that of the variant TL.1,2,4, which is the phenotype of TL(+) leukemias of C57BL. This finding, and the observed quantitative alterations of antigens TL.1,2 and 4, indicate that the Tla (Thymus leukemia antigen) locus was functionally deleted together with the H-2 locus in the process of variant formation, despite absence of selection against cells carrying TL antigens. Representation of H-2 antigens of the remaining haplotype, H-2(b), was quantitatively unchanged.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D005796:Genes; D006648:Histocompatibility; D007942:Leukemia, Experimental / Q000276:immunology*; D051379:Mice; D009368:Neoplasm Transplantation; D009876:Operon; D010641:Phenotype; D013950:Thymus Gland / Q000276:immunology*
D000941:Antigens