Sites of action of amethopterin: intrinsic and acquired drug resistance.
D000818:Animals; D001665:Binding Sites; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004351:Drug Resistance; D005260:Female; D005492:Folic Acid / Q000494:pharmacology; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism; D008727:Methotrexate / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D011485:Protein Binding; D051381:Rats; D012517:Sarcoma, Yoshida / Q000188:drug therapy / Q000378:metabolism; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D014316:Tritium; D005492:Folic Acid; D013762:Tetrahydrofolate Dehydrogenase; D014529:Uridine; D008727:Methotrexate