Studies on type II glycogenosis. Effects of cortisone derivatives on acid  -glucosidase.
Cortisone causes a marked increase in the activity of liver acid alpha-glucosidase 2h after injection into male Wistar rats. Studies on rat liver tissue slices, isolated lysosomes and cultured skin fibroblasts have demonstrated similar elevations of acid alpha-glucosidase activity after incubation with cortisone. Cortisone-treated human liver tissue, obtained by needle biopsy, also shows an increase in acid alpha-glucosidase activity. Neutral alpha-glucosidase activity was not stimulated by cortisone in vivo or in liver slices.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001706:Biopsy; D002247:Carbon Isotopes; D003348:Cortisone / Q000494:pharmacology*; D003470:Culture Media; D046508:Culture Techniques; D004789:Enzyme Activation; D005347:Fibroblasts / Q000201:enzymology; D005947:Glucose / Q000032:analysis; D005959:Glucosidases / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000032:analysis; D006008:Glycogen Storage Disease / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D011506:Proteins / Q000032:analysis; D051381:Rats; D013997:Time Factors
D002247:Carbon Isotopes; D003470:Culture Media; D011506:Proteins; D005969:Glutamate Dehydrogenase; D000135:Acid Phosphatase; D005959:Glucosidases; D005947:Glucose; D003348:Cortisone