An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA.
Messenger RNA from HeLa cells contains, as part of the polynucleotide chain, RNase-resistant sequences that are labeled by adenosine but not by uridine. Heterogeneous nuclear RNA also contains adenylate-rich RNase-resistant regions, but in lower proportion than messenger RNA. Hybridization to DNA of (32)P-labeled messenger RNA reveals that some of the adenylate-rich region is included in the rapidly-hybridizing fraction.
D000227:Adenine Nucleotides / Q000032:analysis*; D000241:Adenosine / Q000378:metabolism; D001345:Autoradiography; D001483:Base Sequence; D002467:Cell Nucleus / Q000032:analysis; D002499:Centrifugation, Density Gradient; D011232:Chemical Precipitation; D004247:DNA / Q000032:analysis*; D006367:HeLa Cells / Q000032:analysis*; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis*; D012260:Ribonucleases / Q000494:pharmacology; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D000227:Adenine Nucleotides; D012333:RNA, Messenger; D014316:Tritium; D012313:RNA; D004247:DNA; D012260:Ribonucleases; D000241:Adenosine; D014529:Uridine