Detection of an antigen associated with acute leukemia.
Antiserums to a purified cell membrane component from a Burkitt's lymphoma tissue culture cell line were produced in rabbits. These antiserums were cytotoxic to peripheral white blood cells from 8 of 15 patients with acute leukemia and 5 of 41 relatives, but not to peripheral white blood cells from leukemia patients in clinical remission or from normal individuals. These antiserums appear to be detecting an acute leukemia associated antigen or antigens.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis; D001345:Autoradiography; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002051:Burkitt Lymphoma / Q000276:immunology; D002859:Chromium Isotopes; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007106:Immune Sera; D037102:Lectins / Q000494:pharmacology; D007945:Leukemia, Lymphoid / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D011817:Rabbits
D000941:Antigens; D000951:Antigens, Neoplasm; D002859:Chromium Isotopes; D007106:Immune Sera; D037102:Lectins