A transition to a compact form of DNA in polymer solutions.
In the presence of over-threshold concentrations of simple neutral polymers and salts, DNA undergoes a cooperative change in its solution structure. Sedimentation studies at low DNA concentrations show that phage DNA molecules collapse into particles approaching the compactness of the contents of phage heads. The interaction between DNA and polymers is thought to be nonspecifically replusive.
D001435:Bacteriophages / Q000032:analysis*; D002499:Centrifugation, Density Gradient; D004279:DNA, Viral / Q000032:analysis*; D004347:Drug Interactions; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009994:Osmolar Concentration; D011095:Polyethylenes; D011108:Polymers; D011205:Povidone; D012965:Sodium Chloride; D012996:Solutions
D004279:DNA, Viral; D011095:Polyethylenes; D011108:Polymers; D012996:Solutions; D012965:Sodium Chloride; D011205:Povidone