Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity.
Treatment with either a flavone or benz(alpha)anthracene before the addition of a potent carcinogen, benzo(alpha)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(alpha)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(alpha)pyrene and 3-methylcholanthrene.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D001580:Benzopyrenes / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D002999:Clone Cells; D006224:Cricetinae; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D008748:Methylcholanthrene / Q000494:pharmacology; D011247:Pregnancy; D013268:Stimulation, Chemical
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D005419:Flavonoids; D008748:Methylcholanthrene