Pararosaniline pamoate (CI-403-A) in the treatment of Schistosoma japonicum infection in the Philippines.
Trials have been carried out, first on a relatively small scale among patients in Manila and later on a larger scale among domiciliary patients in an area of endemic schistosomiasis in Leyte Province, Philippines, with various dosage schedules of pararosaniline pamoate (CI-403-A) to determine that drug's efficacy and optimum dosage against Schistosoma japonicum infection.Given orally in gelatin capsules, the drug was well tolerated even in children, with few side-effects, and was both curative and suppressive when administered in a maximum dosage of 35-40 mg/kg body-weight per day for as many as 52 days spread over a total treatment period of 203 days.The authors recommend its use for mass treatment, especially among schoolchildren, in combination with other established schistosomiasis control measures-health education, environmental sanitation, and snail control.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010679:Philippines; D012394:Rosaniline Dyes / Q000008:administration & dosage*; D012552:Schistosomiasis / Q000188:drug therapy*
D012394:Rosaniline Dyes