Failure of intravenous aspirin to increase gastrointestinal blood loss.
Studies of the effect of intravenous sodium acetylsalicylate (aspirin) on gastrointestinal blood loss with (51)Cr-labelled red cells were made on 15 healthy male volunteers. After a control period of five days 1 g. of sodium acetylsalicylate was infused over a period of 100 minutes twice daily for three days. Faecal blood loss was not increased.In a further six subjects 3 g. of sodium acetylsalicylate was infused over a period of 120 minutes. No salicylate or acetylsalicylate was detected in saliva or gastric washings from these six subjects. Hence gastrointestinal blood loss induced by aspirin may be explained by a local effect on mucosa and not by any systemic effect.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D002859:Chromium Isotopes; D004912:Erythrocytes; D005243:Feces / Q000032:analysis; D005750:Gastric Juice / Q000032:analysis; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009780:Occult Blood; D012459:Salicylates / Q000032:analysis / Q000097:blood; D012463:Saliva / Q000032:analysis
D002859:Chromium Isotopes; D012459:Salicylates; D001241:Aspirin