The effect of 5-hydroxytryptamine on the cotton pellet local inflammatory response in the rat.
The cotton pellet technique was used to evaluate the effect of 5-HT and certain related compounds on granuloma formation in the rat. 5-HT (10 mg/kg) significantly decreased granuloma formation, significantly increased adrenal weight, and significantly decreased thymus weight in normal rats, and significantly decreased granuloma formation and thymus weight in sham-operated rats. On the other hand, 5-HT (10 mg/kg) significantly increased granuloma weight in adrenalectomized rats. Methysergide (1 mg/kg) blocked the inhibitory effect of 5-HT on granuloma formation as well as the changes in weight of adrenal and thymus glands. 5-HIAA (11 mg/kg) and 5-HTP (13 mg/kg) failed to alter granuloma formation.
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects / Q000502:physiology*; D006099:Granuloma; D006897:Hydroxyindoleacetic Acid / Q000494:pharmacology*; D007249:Inflammation; D008784:Methysergide / Q000494:pharmacology*; D009929:Organ Size; D012701:Serotonin / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D006916:5-Hydroxytryptophan; D008784:Methysergide