The toxicity of chlorophacinone and warfarin to house mice (Mus musculus).
Individually caged house mice (Mus m. musculus) were fed 0.025% warfarin (3(2-acetyl-1-phenylethyl)-4-hydroxycoumarin) or 0.025% chlorophacinone (2(1-(p-chlorophenyl)-1-phenyl) acetyl-1,3-indandione) for periods varying from 1 to 21 days. In all, 320 mice, 160 of each sex, were tested.A significant difference was found between the mortalities obtained by the two compounds. In feeding periods varying from 1-5 days chlorophacinone produced a mortality of 60-85% and warfarin only 5-75%. Five per cent, however, did survive 21 days feeding on each compound.A great variation in the susceptibility of individual mice was established for chlorophacinone as well as for warfarin.
D000818:Animals; D000925:Anticoagulants / Q000633:toxicity; D001835:Body Weight; D004351:Drug Resistance; D005260:Female; D007192:Indenes / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D051379:Mice; D012378:Rodenticides; D013997:Time Factors; D014859:Warfarin / Q000633:toxicity*
D000925:Anticoagulants; D007192:Indenes; D007659:Ketones; D012378:Rodenticides; D014859:Warfarin