Quinazoline antifolates as inhibitors of dihydrofolate reductase from human leukemia cells.
D000328:Adult; D000368:Aged; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D011232:Chemical Precipitation; D002845:Chromatography; D002850:Chromatography, Gel; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003857:Deoxyuridine / Q000378:metabolism; D005260:Female; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D006882:Hydroxyapatites; D007939:Leukemia L1210; D007945:Leukemia, Lymphoid / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000201:enzymology*; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology* / Q000378:metabolism; D007962:Leukocytes / Q000201:enzymology; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D000644:Quaternary Ammonium Compounds; D011799:Quinazolines / Q000494:pharmacology*; D013053:Spectrophotometry; D013431:Sulfates; D013762:Tetrahydrofolate Dehydrogenase / Q000097:blood / Q000302:isolation & purification; D014316:Tritium; D014466:Ultraviolet Rays
D004273:DNA, Neoplasm; D005493:Folic Acid Antagonists; D006882:Hydroxyapatites; D000644:Quaternary Ammonium Compounds; D011799:Quinazolines; D013431:Sulfates; D014316:Tritium; D013762:Tetrahydrofolate Dehydrogenase; D003857:Deoxyuridine; D008727:Methotrexate