Long-acting and therapeutic properties of some Soviet and other penicillin preparations in experimental conditions.
The authors describe the results of studies carried out in rabbits infected with syphilis on the therapeutic properties and duration of penicillinaemia of a number of penicillin preparations manufactured in the USSR and of certain others from Czechoslovakia and the USA. These products were studied after intramuscular administration, mainly in doses of 42 000, 84 000 or 168 000 units per kg of body-weight.With all the preparations tested, the first of these doses proved inadequate. Almost, all however, gave satisfactory short-term and long-term results at 84 000 or 168 000 units, but the optimum manner of administration (number of injections and interval between injections) varied according to the preparation. One Soviet and one American preparation showed a considerably lower degree of long-term therapeutic activity and penicillinaemia, although providing a satisfactorily high level of penicillin in the blood for the first few hours after administration.The authors also discuss the reasons for the painfulness of injections of long-acting penicillin and the causes of complications such as embolism following administration.
D000818:Animals; D003604:Czechoslovakia; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D010406:Penicillins / Q000009:adverse effects* / Q000627:therapeutic use*; D011817:Rabbits; D013587:Syphilis / Q000188:drug therapy*; D014586:USSR; D014481:United States
D010406:Penicillins