Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats.
p-Chlorophenylalanine depletes brain serotonin and induces longlasting sexual excitation in male rats. The effect of p-chlorophenylalanine is potentiated by pargyline. Administration of 5-hydroxytryptophan to rats treated with p-chlorophenylalanine plus pargyline blocks the sexual excitation. p-Chlorophenylalanine also elicits sexual excitation in pinealectomized rats; this effect is not mediated by the lack of indole hormones in the pineal but may be the consequence of depletion of 5-hydroxytryptophan in the brain and the resulting imbalance between 5-hydroxytryptophan and catecholamine activity in the central nervous system.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001923:Brain Chemistry; D002700:Chloramines / Q000494:pharmacology; D003192:Compulsive Behavior / Q000187:drug effects*; D006801:Humans; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D010649:Phenylalanine / Q000494:pharmacology*; D010870:Pineal Gland / Q000601:surgery*; D051381:Rats; D012702:Serotonin Antagonists; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D002700:Chloramines; D012702:Serotonin Antagonists; D010649:Phenylalanine; D010293:Pargyline; D006916:5-Hydroxytryptophan