Epsilon-(gamma glutamyl) lysine in fibrin: lack of crosslink formation in Factor 13 deficiency.
Fibrin clots formed in normal plasma contained about 6 mol of epsilon-(gamma-glutamyl)lysine per mol of fibrin, whereas those formed in plasma from individuals with Factor XIII deficiency contained little or none of this crosslink (0.02-0.64 mol/mol of fibrin). Partial supplementation of the plasma with Factor XIII, at a single concentration tested, commensurately increased the number of crosslinks.
D001778:Blood Coagulation Disorders / Q000378:metabolism*; D005176:Factor XIII / Q000494:pharmacology; D005337:Fibrin / Q000032:analysis / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008722:Methods; D010455:Peptides / Q000032:analysis / Q000378:metabolism*
D005971:Glutamates; D010455:Peptides; D005337:Fibrin; D005176:Factor XIII; D008239:Lysine