Role of erythropoietin in 7,12-dimethylbenz(a)anthracene induction of acute chromosome aberration and leukemia in the rat.
The incidence of chromosome aberrations in rat bone marrow, examined 6 hr after the administration of 7,12-dimethylbenz(a)anthracene, was significantly enhanced by induction of anemia 0-48 hr before the carcinogen treatment and was suppressed by induction of polycythemia. The suppressive influence of polycythemia was reversed by sheep erythropoietin injected shortly before or after the carcinogen injection; this suppressive effect was proportional to the dose of erythropoietin used. These data suggest that erythropoietin is essential to make bone-marrow cells susceptible to chromosome aberrations with 7,12-dimethylbenz(a)anthracene. The incidence of carcinogen-induced leukemia was also increased by anemia and suppressed by polycythemia induction.
D000740:Anemia; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations / Q000187:drug effects*; D003348:Cortisone / Q000494:pharmacology; D003864:Depression, Chemical; D004921:Erythropoietin / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects; D007275:Injections, Intravenous; D007942:Leukemia, Experimental / Q000139:chemically induced*; D008247:Lysosomes; D008297:Male; D011086:Polycythemia; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013268:Stimulation, Chemical; D014801:Vitamin A / Q000494:pharmacology
D001551:Benz(a)Anthracenes; D004921:Erythropoietin; D014801:Vitamin A; D003348:Cortisone