Kinetic model of conduction changes across excitable membranes.
A kinetic model describing conduction changes across excitable membranes is proposed. It assumes that a population of discrete membrane sites is distributed among several distinct functional states determined by the voltage across the membrane. Interconversion of these states is postulated to occur by first-order reactions. It provides a satisfactory description of the central aspects of excitable membrane behavior, including current-time and current-voltage relationships, action potential, and effects of inhibitors.
D000166:Acridines / Q000494:pharmacology; D000200:Action Potentials; D002462:Cell Membrane / Q000502:physiology*; D002463:Cell Membrane Permeability; D003634:DDT / Q000494:pharmacology; D003864:Depression, Chemical; D004553:Electric Conductivity / Q000187:drug effects; D004594:Electrophysiology; D007700:Kinetics; D008564:Membrane Potentials; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors
D000166:Acridines; D013779:Tetrodotoxin; D012964:Sodium; D003634:DDT; D011188:Potassium