A new class of cytostatic folic acid antagonists 1-(3,4-dichlorophenyl)-5-isopropyl-biguanide and its boron compounds.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001645:Biguanides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001896:Boron Compounds / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D004285:Dogs; D005493:Folic Acid Antagonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects; D002955:Leucovorin / Q000494:pharmacology; D007970:Leukopenia / Q000139:chemically induced; D051379:Mice; D011817:Rabbits; D051381:Rats; D012510:Sarcoma 180; D013045:Species Specificity
D000962:Antimalarials; D000970:Antineoplastic Agents; D001645:Biguanides; D001896:Boron Compounds; D005493:Folic Acid Antagonists; D002955:Leucovorin