RNA-dependent RNA polymerase activity in influenza virions.
An RNA-dependent RNA polymerase activity has been detected in purified preparations of influenza virus. In contrast to the replicase activity induced in influenza-infected cells, the virion-associated enzyme has an absolute requirement for Mn(++). Most of the RNA synthesized in vitro is complementary to virion RNA.
D000645:Ammonium Sulfate / Q000494:pharmacology; D002499:Centrifugation, Density Gradient; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009975:Orthomyxoviridae / Q000201:enzymology*; D012316:RNA Nucleotidyltransferases / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D012367:RNA, Viral; D014316:Tritium; D014500:Uracil Nucleotides / Q000378:metabolism; D014776:Virus Cultivation
D012367:RNA, Viral; D014500:Uracil Nucleotides; D014316:Tritium; D008345:Manganese; D012316:RNA Nucleotidyltransferases; D008274:Magnesium; D000645:Ammonium Sulfate