An M-associated protein antigen (MAP) of group A streptococci.
A streptococcal antigen that is closely associated with the M-antigen, but is not type specific can be detected by means of a complement-fixation test in extracts of M-positive, but not of M-negative, variants of group A streptococci. Purification of acid extracts results in a concomitant increase in the purity both of the type-specific M-antigen and of the M-associated protein (MAP). Antibody to MAP is present in the sera of patients who have had streptococcal infection. The highest titres are found in patients with rheumatic fever.
D000941:Antigens / Q000032:analysis* / Q000302:isolation & purification; D000942:Antigens, Bacterial / Q000032:analysis; D003168:Complement Fixation Tests; D006801:Humans; D010447:Peptide Hydrolases / Q000494:pharmacology; D012213:Rheumatic Fever / Q000276:immunology; D013290:Streptococcal Infections / Q000276:immunology; D013291:Streptococcus / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial; D010447:Peptide Hydrolases