Two radiation-induced chromosomal inversions in mice (Mus musculus).
Whole-body x-irradiation of male mice has produced presumptive paracentric inversions in 15 animals, as evidenced by high frequencies of first meiotic anaphase bridges. Two of the highest frequencies observed have been propagated through several generations and found to behave as dominant genes. Acentric fragments were observed associated with about 10% of the bridges. The first inversion, in linkage group XIII, has been designated In(13)1Rk, and the second, in linkage group XVII, In(17)2Rk. For In(13)1Rk, recombination was reduced between loci inside and outside the inverted segment.
D000818:Animals; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006579:Heterozygote; D008297:Male; D008540:Meiosis; D051379:Mice; D008815:Mice, Inbred Strains; D011830:Radiation Effects; D011831:Radiation Genetics; D013094:Spermatozoa / Q000166:cytology