Controlled field trials and laboratory studies on the effectiveness of typhoid vaccines in Poland, 1961-64.
In recent years studies of the effectiveness of different typhoid vaccines have been sponsored by the World Health Organization in British Guiana, the USSR, and Yugoslavia. A similarly sponsored study has been made in Poland under the auspices of the Polish Typhoid Committee. In the controlled field trial four types of vaccine were used: (1) bacterial acetone-killed and -dried (vaccines K and P), (2) bacterial formol-killed phenol-preserved (vaccine N), (3) Westphal's endotoxin adsorbed on aluminium hydroxide (vaccine S), and (4) Grasset's vaccine (autolysate of typhoid bacilli adsorbed on aluminium hydroxide; vaccine T). The control vaccine was tetanus toxoid (vaccine O). Laboratory tests were also carried out.In children aged 5-14 years who received two inoculations, vaccine N was the most effective, followed by K; vaccine T was distinctly less effective. In people aged 15-60 years the small number of typhoid cases made evaluation difficult; however, vaccines N and P inoculated once afforded protection, whereas vaccine S imparted none.FURTHER STUDIES ARE DESIRABLE ON THE LABORATORY TESTING OF TYPHOID VACCINES: at present the H and O agglutination tests with sera of immunized rabbits, combined with an active mouse-protection test, can be recommended, provided that a standard typhoid vaccine is used for comparison.
D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D011044:Poland; D011817:Rabbits; D014435:Typhoid Fever / Q000453:epidemiology* / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines / Q000627:therapeutic use*
D014436:Typhoid-Paratyphoid Vaccines