The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients.
A bacteriological and serological study of family contacts of 81 cholera patients was carried out in Dacca, East Pakistan. In the 10-day follow-up, 78 (16.7%) of 466 contacts were found to be infected with Vibrio cholerae; half of them were symptomatic and 29 had to be admitted to hospital. A study of serum pairs revealed a 4-fold, or greater, rise in titre in 86% of those infected in whom diarrhoea was present, and in 77% of individuals with inapparent infections. The infection rate fell markedly with age. Serological tests for vibriocidal antibody on blood specimens collected at the initiation of the follow-up revealed higher titres with increasing age. Vibrio cholerae infection, whether symptomatic or asymptomatic, predominantly occurred in individuals with low titres.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000453:epidemiology / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D003967:Diarrhea / Q000150:complications; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010154:Pakistan; D014733:Vibrio / Q000302:isolation & purification
D000906:Antibodies