Field trials of an inactivated oil-adjuvant vaccine against louping-ill (Arbovirus group B).
A single dose of inactivated louping-ill oil-adjuvant vaccine elicited a sero-logically detectable immune response in sheep lasting for at least 1 year. These sheep when exposed to a natural focus of louping-ill virus were completely protected from clinical disease and 1 year after vaccination were able to pass on a substantial maternal immunity to their lambs.Twenty-nine per cent of unvaccinated sheep, exposed at the same time, died from clinical louping-ill; half of the survivors showed positive sero-conversion and became immune, while the other half remained susceptible. The incidence of fatal encephalomyelitis in sheep which were known to have circulated virus exceeded 50% in 2 out of 3 trials conducted simultaneously in different locations in Scotland in 1969.
D000276:Adjuvants, Immunologic; D000818:Animals; D000906:Antibodies / Q000032:analysis; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D007109:Immunity; D008146:Louping Ill / Q000517:prevention & control*; D008297:Male; D008431:Maternal-Fetal Exchange; D009821:Oils; D011247:Pregnancy; D012621:Seasons; D012756:Sheep; D014765:Viral Vaccines / Q000008:administration & dosage*; D014887:Weather
D000276:Adjuvants, Immunologic; D000906:Antibodies; D009821:Oils; D014765:Viral Vaccines