Effects of triiodothyronine-induced hypermetabolism on factor 8 and fibrinogen in man.
Triiodothyronine (liothyronine sodium) (400-500 mug/day for 14 days) was given to six normal subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < 0.05); fibrinogen increased from 344 to 581 mg/100 ml (P < 0.01). To test whether the increases in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol (20 mg every 6 hr) was given orally to four other normal subjects in addition to triiodothyronine for 14 days. Factor VIII increased from 100 to 161%; fibrinogen increased from 374 to 564% (P < 0.01). Factor VIII activity did not change in a severe classical hemophiliac made hypermetabolic with triiodothyronine, but it increased from 39 to 82% in a patient with von Willebrand's disease. Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen. These results suggest that the increases in clotting factor activity during triiodothyronine-induced hypermetabolism reflect an effect of increased protein synthesis rather than enhanced stimulation of beta adrenergic receptors.
D001481:Basal Metabolism / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D005169:Factor VIII / Q000032:analysis / Q000378:metabolism*; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism*; D006467:Hemophilia A / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood; D008297:Male; D008715:Methionine / Q000097:blood; D011433:Propranolol / Q000494:pharmacology; D012643:Selenium; D011984:Sensory Receptor Cells / Q000187:drug effects*; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology*; D014842:von Willebrand Diseases / Q000097:blood
D014284:Triiodothyronine; D005169:Factor VIII; D005340:Fibrinogen; D011433:Propranolol; D008715:Methionine; D012643:Selenium; D013974:Thyroxine; D004837:Epinephrine