The X-Y-Z scheme of immunocyte maturation. VII. Cell division and the establishment of short-term IgM memory.
Short-term IgM memory is established within 1 day after primary injection. This 1 day priming is independent of cell division as it can take place in the pressence of methotrexate or hydroxyurea. The primary response involves a similar 1 day nonproliferative phase. On the contrary, cells responding to a second injection of antigen after short priming intervals begin to proliferate within hours. This implies a qualitative difference between the antigen-sensitive cells in primed and normal animals. After 1 day, further proliferative expansion of memory can occur, which is probably antigen dependent. The response to several dose regimens indicates that repeated antigenic contact is needed to maintain the IgM response.
D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens; D002455:Cell Division / Q000187:drug effects*; D004912:Erythrocytes; D005260:Female; D006461:Hemolysis; D006918:Hydroxyurea / Q000494:pharmacology; D007108:Immune Tolerance; D007075:Immunoglobulin M; D007274:Injections, Intraperitoneal; D002955:Leucovorin / Q000494:pharmacology; D008297:Male; D008722:Methods; D008727:Methotrexate / Q000494:pharmacology*; D051379:Mice; D013154:Spleen / Q000276:immunology; D013997:Time Factors
D000941:Antigens; D007075:Immunoglobulin M; D002955:Leucovorin; D006918:Hydroxyurea; D008727:Methotrexate