Amino acid sequence of the light chain from a mouse myeloma protein with anti-hapten activity: evidence for a third type of light chain.
A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The "variable" segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.
D000483:Alleles; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D000906:Antibodies; D005260:Female; D006241:Haptens; D007106:Immune Sera; D007136:Immunoglobulins / Q000032:analysis; D007456:Iodine Isotopes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009194:Myeloma Proteins / Q000032:analysis*; D009374:Neoplasms, Experimental; D010455:Peptides / Q000032:analysis; D011817:Rabbits; D013045:Species Specificity
D000596:Amino Acids; D000906:Antibodies; D006241:Haptens; D007106:Immune Sera; D007136:Immunoglobulins; D007456:Iodine Isotopes; D009194:Myeloma Proteins; D010455:Peptides