Tissue distribution of trivalent antimony in mice infected with Schistosoma mansoni.
The work described in this paper is designed to use the very high analytical sensitivity of neutron-activation analysis. The antimony content of individual organs and pieces of organs have been analysed as part of an investigation of the chemotherapy of schistosomiasis. The results illustrate the great, and as yet relatively unapplied, value of this technique in dealing with the investigation of trace elements in biological systems. Values such as those given form firm bases on which further studies can be built and show that the single animal has the same metabolic reactions as those deduced from bulked samples, but of course with individual variations.
D000818:Animals; D000965:Antimony / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use; D008297:Male; D051379:Mice; D012547:Schistosoma / Q000378:metabolism; D012552:Schistosomiasis / Q000188:drug therapy*
D000965:Antimony