The influence of neighboring base pairs upon base-pair substitution mutation rates.
The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.
D000225:Adenine / Q000494:pharmacology; D001435:Bacteriophages; D001483:Base Sequence; D004261:DNA Replication; D009154:Mutation / Q000187:drug effects; D011119:Polynucleotides
D011119:Polynucleotides; D000225:Adenine