Teratogenic evaluation of 2,4,5-T.
The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in two strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally. The incidences of both cystic kidney and cleft palate were increased in the C57BL/6 mice as well as the incidence of cleft palate in the AKR mice. The incidence of cystic kidney was also increased in the rats. In addition, an increase in the ratio of liver weight to body weight in the mouse fetus and the occurrence of hemorrhagic gastrointestinal tract in the rat fetus suggest that this compound also has fetotoxic properties.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced; D004121:Dimethyl Sulfoxide; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006016:Glycolates / Q000633:toxicity*; D006540:Herbicides / Q000633:toxicity*; D006722:Honey; D052177:Kidney Diseases, Cystic / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D051379:Mice; D009929:Organ Size; D011247:Pregnancy
D006016:Glycolates; D006540:Herbicides; D004121:Dimethyl Sulfoxide