Postirradiation cell division in 5-fluorouracil-pre-treated Escherichia coli.
The correlation between 5-fluorouracil-induced resistance to ultraviolet (UV) light and the ability of bacterial cells to repair irradiation damage was investigated in various strains of Escherichia coli. Preincubation with 5-fluorouracil did not influence the dark-repair mechanism. It affected, however, the UV light-induced damage of cell division in filament-forming strains. It is suggested that the delay in postirradiation macromolecular synthesis of 5-fluorouracil-pretreated bacteria plays a decisive role in the recovery process leading to cross cell wall-forming ability in the damaged strains.
D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects*; D005472:Fluorouracil / Q000494:pharmacology*; D008853:Microscopy; D011830:Radiation Effects; D014466:Ultraviolet Rays
D005472:Fluorouracil