[Disturbance of the intensity of secretion and chemical composition of bile in liver dystrophy induced by carbon tetrachloride].
Liver dystrophy induced by carbon tetrachloride results in inhibition of intensity of bile secretion and cholate formation and upsets discharge of bilirubin and cholesterol with bile. Inhibition of cholate synthesis might be accounted for by repressed production of deoxycholic and cholic acid from cholesterol as well as by repressed conjugation of cholic acid with taurine and glycine. Cessation of carbon tetrachloride injections is followed by steady restoration of bile formation: first of all is discharge of bilirubin restored, then discharge of cholesterol, and much later intensity of bile discharge and formation of bile acids.
D000818:Animals; D001646:Bile / Q000032:analysis / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D008297:Male; D051381:Rats
Narusheniia intensivnosti zhelcheotdeleniia i khimicheskogo sostava zhelchi pri distrofii pecheni, vyzvannoĭ chetyrekhkhloristym uglorodom.