Platinum-induced filamentous growth in Escherichia coli.
Certain group VIIIB transition metal compounds were found to inhibit cell division in Escherichia coli, causing marked filamentous growth. Gram-negative bacilli were the most sensitive to this effect, whereas gram-positive bacilli responded only at near-toxic levels of the metal. None of the cocci tested showed any apparent effect. Cytokinesis (cross-septation) can be initiated by removal or decrease of platinum, but not by treatment with pantoyl lactone, divalent cations, or a temperature of 42 C.
D001419:Bacteria / Q000254:growth & development; D002455:Cell Division / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D007501:Iron / Q000494:pharmacology; D007783:Lactones / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008858:Microscopy, Phase-Contrast; D010984:Platinum / Q000494:pharmacology*; D013696:Temperature; D014001:Tin / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D007783:Lactones; D008345:Manganese; D010984:Platinum; D014001:Tin; D007501:Iron; D008274:Magnesium; D015032:Zinc