Tolerance and immunity to maternally derived incompatible IgG 2a -globulin in mice.
Progeny mice were confronted with maternal gamma-globulin of a different allotype by either back-cross mating, intercross mating, or by foster nursing. In all cases, many mice subsequently produced alloantibodies directed against the incompatible maternal type of IgG(2a)-globulin. In one series of experiments, immunologic tolerance to the maternally derived gamma-globulin was demonstrated to exist in the period before formation of spontaneous antibody. The state of tolerance was then lost, unless maintenance injections of foreign gamma-globulin were given. These studies demonstrate in a natural situation that maternally derived foreign proteins can first induce a state of immunological tolerance which is followed, after disappearance of the antigen, by a state of immunity. As such, this parallels the experimental induction of tolerance to foreign proteins by neonatal injections.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic; D005260:Female; D007108:Immune Tolerance; D007074:Immunoglobulin G; D007136:Immunoglobulins; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D007136:Immunoglobulins