The use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate.
D000284:Administration, Oral; D000818:Animals; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007410:Intestinal Diseases / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D002955:Leucovorin / Q000008:administration & dosage*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D051379:Mice
D002955:Leucovorin; D008727:Methotrexate