L-asparaginase: toxicity to normal and leukemic human lymphocytes.
Quantitative in vitro tests showed that purified preparations of L-asparaginase from Escherichia coli were more toxic to blood lymphocytes from 12 of 15 patients with chronic lymphocytic leukemia than to lymphocytes from 25 persons with normal hemograms. Incubation for 7 days with 10 units per milliliter killed, on the average, 77 percent of leukemic and 34 percent of normal lymphocytes. The reagent produced appreciable toxicity to leukemic lymphocytes after 2 days of incubation.
D000581:Amidohydrolases / Q000633:toxicity*; D000818:Animals; D046508:Culture Techniques; D004926:Escherichia coli; D006168:Guinea Pigs; D006801:Humans; D007945:Leukemia, Lymphoid; D008214:Lymphocytes / Q000187:drug effects*
D000581:Amidohydrolases