Some clinical and physiologic effects of a thioxanthene derivative, thiothixene (P-4657B), in 20 newly hospitalized male schizophrenics.
This study was designed to evaluate some of the effects of a new thioxanthene, thiothixene (P-4657B), in 20 male schizophrenic patients recently admitted to Bellevue Hospital. The results of a dosage range trial indicated that at a dosage of approximately 50 mg per day, toxic and side effects as well as therapeutic effects were at their maximum. Parkinsonian reactions (in 17 of 20 patients) with restlessness and akathisia were the most prominent of these effects. Also, activation of psychopathology was observed in six of 20 subjects. Thiothixine did exhibit some antipsychotic activity, but it does not appear to be as valuable as it has been reported to be in chronic schizophrenic patients.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*; D013888:Thiothixene / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D013888:Thiothixene