The role of shikimic acid in the biosynthesis of vitamin K2.
1. Shikimic acid was shown to be a precursor of vitamin K(2) (MK-8) in Escherichia coli. 2. The benzene ring of the naphthaquinone arises from shikimic acid. 3. The methyl group of methionine is incorporated into vitamin K(2). 4. A scheme relating the biosynthesis of vitamin K(2) and ubiquinone to the general pathway of aromatic biosynthesis is proposed.
D000085:Acetates / Q000378:metabolism; D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000378:metabolism*; D008715:Methionine / Q000378:metabolism; D011809:Quinones; D012765:Shikimic Acid / Q000494:pharmacology*; D013057:Spectrum Analysis; D014812:Vitamin K / Q000096:biosynthesis*
D000085:Acetates; D002247:Carbon Isotopes; D011809:Quinones; D014812:Vitamin K; D012765:Shikimic Acid; D008715:Methionine