Conversion of p,p' -DDT to p,p' -DDD by intestinal flora of the rat.
p,p-DDD [1,1-dichloro- 2,2-bis(p-chlorophenyl)-ethane] occurs in the feces and livers of rats, that are given p, p-DDT [1,1,1-trichloro-2,2-bis-(p-chlorophenyl)-ethane] by stomach tube, but not of rats injected intraperitoneally with p,p-DDT. Coliform bacteria, isolated from feces of control animals, can effect reductive dechlorination of p,p-DDT to p,p-DDD. These findings indicate that the normal flora of the gastrointestinal tract, rather than the liver, as others have suggested, is the major source of the p,p-DDD that is found in animals fed p,p-DDT.
D000818:Animals; D000970:Antineoplastic Agents / Q000096:biosynthesis*; D002849:Chromatography, Gas; D003634:DDT / Q000378:metabolism*; D004754:Enterobacter / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D005243:Feces; D066298:In Vitro Techniques; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D051381:Rats
D000970:Antineoplastic Agents; D003634:DDT