Osteomalacia with long-term anticonvulsant therapy in epilepsy.
The investigation and treatment of osteomalacia are described in four patients with epilepsy treated with long-term anticonvulsant therapy. It is suggested that drug-mediated enzyme induction may be the mechanism responsible by causing a greatly increased inactivation of vitamin D in these patients.
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D001706:Biopsy; D002118:Calcium / Q000378:metabolism; D004790:Enzyme Induction; D004827:Epilepsy / Q000188:drug therapy*; D004872:Ergocalciferols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010018:Osteomalacia / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D010672:Phenytoin / Q000009:adverse effects; D010758:Phosphorus / Q000378:metabolism; D011324:Primidone / Q000009:adverse effects; D014807:Vitamin D / Q000378:metabolism
D000927:Anticonvulsants; D004872:Ergocalciferols; D011324:Primidone; D014807:Vitamin D; D010758:Phosphorus; D010672:Phenytoin; D000469:Alkaline Phosphatase; D002118:Calcium