Sudden unexplained death in infancy and hyperimmunization.
Serum immunoglobulin concentrations, predominantly IgM, were raised in 72% of 39 sudden infant death cases, consistent with a state of prolonged or repeated antigenic stimulation.Anti-antibody was found in cases of sudden death significantly more frequently than in ill but living control infants. It is suggested that anti-antibody might participate in fatal anaphylaxis in such cases.
D000367:Age Factors; D000707:Anaphylaxis; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D003645:Death, Sudden; D005260:Female; D005759:Gastroenteritis / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D012141:Respiratory Tract Infections / Q000276:immunology; D012737:Sex Factors
D000888:Antibodies, Anti-Idiotypic; D007136:Immunoglobulins