[Transaminase activity of the cortical layer of the kidney of rats of different ages and sex after administration of hydrocortisone and insulin].
Response of cortical layer of rat kidney to separate and combined administration of hydrocortisone and insulin, as manifested by the activity of aspartate-alpha-ketoglutarate transaminase (Asp-T) and alanine-alpha-ketoglutarate transaminase (Ala-T), varied in males and females of different age. Prolonged administration of insulin to normal preadolescent rats and to adult males and females did not affect the activity of Asp-T and Ala-T in the cortical layer of kidney. During simultaneous prolonged administration of hydrocortisone and insulin to preadolescent male rats, there occurred no increase in the activity of Asp-T induced by administration of hydrocortisone alone. During simultaneous prolonged administration of hydrocortisone and insulin to adult male rats, activity of Asp-T of the cortical layer of kidney remained at the same level at after administration of hydrocortisone alone.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D004357:Drug Synergism; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D012737:Sex Factors; D000637:Transaminases / Q000378:metabolism*
D007328:Insulin; D000637:Transaminases; D006854:Hydrocortisone
Aktivnost' transaminaz korkovogo sloia pochek krys raznogo vozrasta i pola posle vvedeniia im gidrokortizona i insulina.