Evaluation of the treatment of human Schistosoma mansoni infection by the quantitative oogram technique.
Egg output is the only measure available for quantitative assessment of the activity of chemotherapeutic agents in Schistosoma mansoni infection. In the light of eight years' experience in the preparations of oograms, the authors suggest a simplified classification of S. mansoni eggs and certain improvements in the oogram technique by which quantitative data are obtained for comparison before and after treatment.Ten cases, taken from clinical trials on a variety of schistosomicidal compounds, are presented to illustrate the use of the quantitative oogram and the types of result obtained with active, partially active and inactive drugs.
D000293:Adolescent; D002986:Clinical Trials as Topic; D006801:Humans; D012007:Rectum / Q000473:pathology*; D012552:Schistosomiasis / Q000188:drug therapy*