Control of the activity of Escherichia coli carbamoyl phosphate synthetase by antagonistic allosteric effectors.
The synthesis of carbamoyl phosphate required in both arginine and pyrimidine biosyntheses is carried out by a single enzyme in Escherichia coli. Opposed effects of pyrimidine nucleotides and of ornithine on the activity of the enzyme ensure a proper supply of carbamoyl phosphate according to the needs of the two biosynthetic sequences.
D004926:Escherichia coli / Q000201:enzymology*; D008025:Ligases / Q000378:metabolism*; D009952:Ornithine / Q000494:pharmacology*; D014500:Uracil Nucleotides / Q000494:pharmacology*
D014500:Uracil Nucleotides; D009952:Ornithine; D008025:Ligases