Drug-induced tolerance for skin allografts across the H-2 barrier in adult mice.
Mice treated with methylhydrazine derivatives for 3 to 4 weeks before the transplantation showed markedly prolonged survival times for allogeneic skin grafts differing at the H-2 histocompatibility locus. Presumably permanent tolerance was induced in about 20 to 30 percent of the mice when the drug treatment was combined with a single injection of additional donor antigen. The tolerance persists without further drug treatment and is specific for donor tissue.
D000818:Animals; D006834:Hydrazines / Q000494:pharmacology*; D007108:Immune Tolerance; D051379:Mice; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D006834:Hydrazines