Formylmethionine codon AUG as an initiator of polypeptide synthesis.
Oligonucleotide messengers containing the sequence AUG at or near the 5' end of the chain stimulate the incorporation of N-formylmethionine,but not of free (unformylated) methionine. AUG is considerably more active in this regard than UUG, the other N-formylmethionine codon. The coding activity of subsequent in-phase triplets in the 3' direction from AUG is markedly stimulated by this codon.
D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli; D005561:Formates; D005815:Genetic Code; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008715:Methionine; D009711:Nucleotides; D010455:Peptides; D010649:Phenylalanine; D011874:Radiometry; D014316:Tritium
D002247:Carbon Isotopes; D005561:Formates; D009711:Nucleotides; D010455:Peptides; D014316:Tritium; D010649:Phenylalanine; D008715:Methionine