A double-blind comparison of two analgesics with placebo control.
The value of adding a sedative to commonly used analgesic agents to promote further the relief of pain was studied by a double-blind procedure in 90 post-surgical patients during 188 pain episodes. In moderate pain episodes, no statistically significant difference between the analgesic-sedative combination (Fiorinal-C(1/4)) and the analgesic (APC-C) was observed, although both compounds were superior to placebo (p <0.001). In severe pain episodes, the analgesic-sedative combination was superior to the analgesic alone; the analgesic, in turn, was superior to placebo (p <0.001).It is concluded that analgesia is more effective if associated apprehension is relieved by sedation.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D001463:Barbiturates / Q000627:therapeutic use*; D002110:Caffeine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003061:Codeine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010615:Phenacetin / Q000627:therapeutic use*
D000700:Analgesics; D001463:Barbiturates; D002110:Caffeine; D010615:Phenacetin; D001241:Aspirin; D003061:Codeine