Hypogonadotropic hypogonadism in patients with multiple congenital defects.
Several syndromes have been reviewed in which hypogonadotropism is associated with multiple somatic and neurologic anomalies. A review of the literature indicates that these conditions demonstrate considerable clinical heterogeneity. In the several hypogonadotropic syndromes described to date autosomal and X-linked transmission have been implicated in the inheritance of the hypogonadism. The associated neurologic and somatic anomalies may segregate independent of the hypogonadism and in some instances may have a separate mode of transmission.
D000015:Abnormalities, Multiple / Q000150:complications*; D000293:Adolescent; D000328:Adult; D002524:Cerebellar Ataxia / Q000150:complications / Q000235:genetics; D003117:Color Vision Defects / Q000235:genetics; D004827:Epilepsy / Q000235:genetics; D005058:Eunuchism / Q000235:genetics; D005799:Genes, Dominant; D005808:Genes, Recessive; D006062:Gonadotropins / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000150:complications* / Q000235:genetics; D007057:Ichthyosis / Q000151:congenital; D008607:Intellectual Disability / Q000235:genetics; D007849:Laurence-Moon Syndrome / Q000235:genetics; D008297:Male; D000857:Olfaction Disorders / Q000150:complications; D012730:Sex Chromosomes; D013577:Syndrome
D006062:Gonadotropins