Metabolic cooperative control of electrolyte levels by adenosine triphosphate in the frog muscle.
This study examines the effects of metabolic inhibitors on the content of cellular K, Na, and adenosine triphosphate (ATP). ATP and K are seen to fall in the inhibited tissues. The ATP content is correlated with the K content. The role of ATP is examined according to a recent biophysical approach. It is suggested that ATP may control the electrolyte levels by inducing conformational changes in the cytoplasmic proteins.
D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001001:Anura; D001151:Arsenic / Q000494:pharmacology; D001386:Azides / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D002729:Chloromercuribenzoates / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D004140:Dinitrophenols / Q000494:pharmacology; D005985:Glyceraldehyde / Q000494:pharmacology; D007455:Iodine / Q000494:pharmacology; D007461:Iodoacetates / Q000494:pharmacology; D008314:Malonates / Q000494:pharmacology; D008433:Mathematics; D008954:Models, Biological; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D011487:Protein Conformation; D011894:Rana pipiens; D012964:Sodium / Q000378:metabolism*
D001386:Azides; D001565:Benzoates; D002729:Chloromercuribenzoates; D003486:Cyanides; D004140:Dinitrophenols; D007461:Iodoacetates; D008314:Malonates; D005985:Glyceraldehyde; D000255:Adenosine Triphosphate; D007455:Iodine; D012964:Sodium; D001151:Arsenic; D011188:Potassium; D002746:Chlorpromazine