Experimental and clinical studies with a new antimonial preparation for the treatment of schistosomiasis.
This paper presents the results of a clinical study in which a new antimony preparation-a chelate of dimethylcysteine with antimony sodium tartrate ("NAP")-was administered intramuscularly at a total dosage of 2 g (5x400 mg, corresponding to 290 mg of Sb) to 400 patients with schistosomiasis. Among 108 patients in a rural population the treatment was on the whole well accepted (97% completed the intensive course of injections), thus indicating that NAP would be useful for the mass treatment of schistosomiasis.
D000328:Adult; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000965:Antimony / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011188:Potassium; D012552:Schistosomiasis / Q000188:drug therapy*; D012964:Sodium; D013644:Tartrates
D000871:Anthelmintics; D013644:Tartrates; D000965:Antimony; D012964:Sodium; D011188:Potassium